WorldWideScience

Sample records for achieving abuja targets

  1. Application of Geospatial Information System to Assess the Effectiveness of the Mdg Target in Amac Metropolis-Abuja, Nigeria

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    T.T. Youngu

    2012-03-01

    Full Text Available This study aims to assess the effectiveness of the MDG target as it concerns, the state of education in Abuja Municipal Area Council (AMAC metropolis-Nigeria. One of the educational challenges faced in developing countries is how to know which school to send children to. This is mainly due to lack of detailed information as to, what school offers, what type of education, and at what fee. But with Geospatial Information Systems (GIS providing information about primary and secondary schools, Millennium Development Goals’ (MDGs’ vision of literacy for 15-24 year olds will be achieved. The development of geospatial database information system of primary and secondary schools for Garki and Wuse districts, Abuja, was embarked upon to provide timely, consistent and accurate information to decision makers for use in achieving this particular target of the Millennium Development Goals (MDGs. The delay in achievement of this target is not because governments in developing countries aren’t putting maximum effort, but because these governments are choosing to put the cart before the horse. Sustainable literacy level cannot be achieved without an effective framework charged with the collection, storage, query, analysis and management of the relevant data. What is needed is a system that provides government with data about all educational facilities within required proximity and determines availability of the required facilities. GIS is that decision making technology, which integrates ‘spatially referenced data’ with a problem solving environment. The method employed was to acquire both spatial and attribute data of every primary and secondary school in Garki and Wuse districts. The spatially referenced database was created using Microsoft Access 2007 and ArcGIS 9.2 software. The database was queried and the results of the queries analyzed. The results showed that 60% of the schools didn’t have access to Internet. Twenty-one (21 percent had no

  2. Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets

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    Tetteh Gladys

    2009-10-01

    the complexity and unclear messages regarding drug policy changes. Conclusion Kenya, like many other African countries, is still far from achieving the Abuja targets. The government, with support from donors, should invest adequately in mechanisms that promote access to effective treatment. Such approaches should focus on factors influencing multiple dimensions of access and will require the cooperation of all stakeholders working in malaria control.

  3. CHARACTERIZATION OF EXTERNAL INDUCED CORROSION DEGRADATION OF AJAOKUTA-ABUJA GAS PIPELINE SYSTEM, NIGERIA

    OpenAIRE

    ADEDIPE OYEWOLE

    2011-01-01

    Characterization of External Induced corrosion degradation of Ajaokuta- Abuja gas pipeline system was successfully carried out. The objective of this work is to analyze the mechanism of corrosion, analyze the effect of the corrosion on oil and gas pipeline and to evaluate the corrosion potential of a pipeline route. These were achieved by carrying out resistivity experiment on every one kilometer on the right of way (ROW) of the pipeline. Soil and water aggressiveness test was also carried ou...

  4. Achieving the Renewable Energy Target for Jamaica

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    Abdullahi Olabode ABDULKADRI

    2014-05-01

    Full Text Available ieving the Renewable Energy Target for Jamaica Abstract: The high cost of energy in Jamaica, one of the highest in the Caribbean region, is usually cited as a hindrance to industrial development and efficiency, especially in the manufacturing sector. High energy cost is also considered to be a national energy security issue and the government is taking steps to ensure adequate supply of energy at affordable prices. In the current National Development Plan, the government has set a target for renewable energy sources to supply 20% of the country's energy need by the year 2030. Using a linear programing model of energy planning, we examine how realistically this target could be achieved. Our findings indicate that the 20% renewable energy target is technically achievable with the optimal plan showing a mixture of wind power, hydropower and bagasse power but no solar power. However, when the timeline for investment in new generating capacities that will ensure the attainment of the target is considered, it becomes highly improbable that the target will be met. This study fills the gap that exists in evidence-based analysis of energy policy in Jamaica.

  5. Cooperation Mechanisms To Achieve Eu Renewable Targets

    DEFF Research Database (Denmark)

    Klinge Jacobsen, Henrik; Pade, Lise-Lotte; Schröder, Sascha Thorsten;

    2014-01-01

    for cooperation mechanisms such as joint support schemes for promoting renewable energy to meet the 2020 targets. The potential coordination benefits, with more efficient localisation and composition of renewable investment, can be achieved by creating new areas/sub-segments of renewable technologies where...... support costs are shared and credits are transferred between countries. Countries that are not coordinating support for renewable energy might induce inefficient investment in new capacity that would have been more beneficial elsewhere and still have provided the same contribution to meeting the 2020 RES...... of the wind capacity resulting in lower prices, which will affect existing conventional producers. This development will be opposed by conventional producers, whereas consumers will support such a strategy. A major barrier is the timing of RES targets and the uncertainty regarding future targets. We...

  6. Assessment of Recreational Facilities in Federal Capital City, Abuja, Nigeria

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    Cyril Kanayo Ezeamaka

    2016-06-01

    Full Text Available Abuja Master Plan provided development of adequate Green Areas and other Recreational Facilities within the Federal Capital City (FCC, as part of its sustainability principles and provided for these recreational facilities within each neighborhood (FCDA, 1979. However, there have been several recent foul cries about the negative development of recreational facilities and the abuse of the Master Plan in the FCC.  The motivation for carrying out this study arose from the observation that recreational facilities in Phase 1 of the Federal Capital City Abuja are not clearly developed as intended by the policy makers and thus, the need to identify the recreational facilities in the Phase 1 of FCC and observe their level of development as well as usage. The field survey revealed that the Central Business District and Gazupe have higher numbers of recreational facilities with 45 and 56. While Wuse II (A08 and Wuse II (A07 Districts have lesser recreational facilities with 10 and 17. The field survey further revealed that all the districts in Phase 1 have over 35% cases of land use changes from recreational facilities to other use. The survey shows that over 65% of these recreational facilities are fully developed. The study also shows that just about 11% of the recreational sporting facilities were developed in line with the Abuja Master Plan in Phase 1. The study revealed that recreational facilities in Phase 1 of the FCC, Abuja has not being developed in compliance with the Abuja Master Plan.

  7. Inflation Targeting at 20 - Achievements and Challenges

    OpenAIRE

    Scott Roger

    2009-01-01

    This paper provides an overview of inflation targeting frameworks and macroeconomic performance under inflation targeting. Inflation targeting frameworks are generally quite similar across countries, and a broad consensus has developed in favor of "flexible" inflation targeting. The evidence shows that, although inflation target ranges are missed frequently in most countries, the inflation and growth performance under inflation targeting compares very favorably with performance under alternat...

  8. Synergies and trade-offs in achieving global biodiversity targets.

    Science.gov (United States)

    Di Marco, Moreno; Butchart, Stuart H M; Visconti, Piero; Buchanan, Graeme M; Ficetola, Gentile F; Rondinini, Carlo

    2016-02-01

    After their failure to achieve a significant reduction in the global rate of biodiversity loss by 2010, world governments adopted 20 new ambitious Aichi biodiversity targets to be met by 2020. Efforts to achieve one particular target can contribute to achieving others, but different targets may sometimes require conflicting solutions. Consequently, lack of strategic thinking might result, once again, in a failure to achieve global commitments to biodiversity conservation. We illustrate this dilemma by focusing on Aichi Target 11. This target requires an expansion of terrestrial protected area coverage, which could also contribute to reducing the loss of natural habitats (Target 5), reducing human-induced species decline and extinction (Target 12), and maintaining global carbon stocks (Target 15). We considered the potential impact of expanding protected areas to mitigate global deforestation and the consequences for the distribution of suitable habitat for >10,000 species of forest vertebrates (amphibians, birds, and mammals). We first identified places where deforestation might have the highest impact on remaining forests and then identified places where deforestation might have the highest impact on forest vertebrates (considering aggregate suitable habitat for species). Expanding protected areas toward locations with the highest deforestation rates (Target 5) or the highest potential loss of aggregate species' suitable habitat (Target 12) resulted in partially different protected area network configurations (overlapping with each other by about 73%). Moreover, the latter approach contributed to safeguarding about 30% more global carbon stocks than the former. Further investigation of synergies and trade-offs between targets would shed light on these and other complex interactions, such as the interaction between reducing overexploitation of natural resources (Targets 6, 7), controlling invasive alien species (Target 9), and preventing extinctions of native

  9. Synergies and trade-offs in achieving global biodiversity targets.

    Science.gov (United States)

    Di Marco, Moreno; Butchart, Stuart H M; Visconti, Piero; Buchanan, Graeme M; Ficetola, Gentile F; Rondinini, Carlo

    2016-02-01

    After their failure to achieve a significant reduction in the global rate of biodiversity loss by 2010, world governments adopted 20 new ambitious Aichi biodiversity targets to be met by 2020. Efforts to achieve one particular target can contribute to achieving others, but different targets may sometimes require conflicting solutions. Consequently, lack of strategic thinking might result, once again, in a failure to achieve global commitments to biodiversity conservation. We illustrate this dilemma by focusing on Aichi Target 11. This target requires an expansion of terrestrial protected area coverage, which could also contribute to reducing the loss of natural habitats (Target 5), reducing human-induced species decline and extinction (Target 12), and maintaining global carbon stocks (Target 15). We considered the potential impact of expanding protected areas to mitigate global deforestation and the consequences for the distribution of suitable habitat for >10,000 species of forest vertebrates (amphibians, birds, and mammals). We first identified places where deforestation might have the highest impact on remaining forests and then identified places where deforestation might have the highest impact on forest vertebrates (considering aggregate suitable habitat for species). Expanding protected areas toward locations with the highest deforestation rates (Target 5) or the highest potential loss of aggregate species' suitable habitat (Target 12) resulted in partially different protected area network configurations (overlapping with each other by about 73%). Moreover, the latter approach contributed to safeguarding about 30% more global carbon stocks than the former. Further investigation of synergies and trade-offs between targets would shed light on these and other complex interactions, such as the interaction between reducing overexploitation of natural resources (Targets 6, 7), controlling invasive alien species (Target 9), and preventing extinctions of native

  10. Prevalence of vulvovaginal candidiasis among nonpregnant women attending a tertiary health care facility in Abuja, Nigeria

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    Emeribe AU

    2015-06-01

    Full Text Available Anthony Uchenna Emeribe,1 Idris Abdullahi Nasir,2 Justus Onyia,2 Alinwachukwu Loveth Ifunanya31Department of Medical Laboratory Science, University of Calabar, Calabar, Cross River State, Nigeria; 2Department of Medical Microbiology, University of Abuja Teaching Hospital, Gwagwalada, Federal Capital Territory, Nigeria; 3Department of Medical Laboratory, School of Health Technology, Tsafe, Zamfara State, NigeriaBackground: Candida spp. are normal flora of the vagina that eventually become pathogenic under some prevailing conditions, and thus present as a common etiology of vulvovaginitis. When prompt recognition and laboratory confirmation is not achieved, this could lead to devastating genital discomfort and a major reason for frequent hospital visits.Aims: This was a cross-sectional prospective study that aimed to determine the prevalence and some associated risk factors of vulvovaginal candidiasis (VVC among nonpregnant women attending University of Abuja Teaching Hospital, Gwagwalada.Subjects and methods: A pair of high vaginal swab and endocervical swab samples was collected from each of 200 individual participating subjects. They were separately inoculated on Sabouraud's dextrose agar and incubated aerobically at 33°C for 48 hours. Ten percent KOH wet mount and Gram staining was done on swabs and colonies, respectively. Structured questionnaires were used to obtain sociodemographic and clinical data.Results: Of the 200 participating subjects, the prevalence of Candida albicans was 6.5% and that of non-albicans candidiasis 7.5%. Candidiasis was observed mostly among the 20- to 30-year age-group. All subjects with Candida-positive culture had been on antibacterial therapy prior to participating in this study – 28 (100%. There was a statistical relationship between the prevalence of VVC with previous antibacterial therapy (P<0.05, but not with age or other prevailing health conditions studied (P>0.05.Conclusion: The outcome of this study

  11. Socioeconomic factors contributing to exclusion of women from maternal health benefit in Abuja, Nigeria

    OpenAIRE

    Oyewale, Tajudeen O.; Thandisizwe R. Mavundla

    2015-01-01

    Background: An understanding of the predictive effect of socioeconomic characteristics (SECs) of women on maternal healthcare service utilisation is essential in order to maximise maternal health benefits and outcomes for the newborn.Objectives: To describe how SECs of women contribute to their exclusion from maternal health benefits in Abuja Municipal Areas Council (AMAC) in Abuja, Nigeria.Method: A non-experimental, facility-based cross-sectional survey was done. Data were collected from 38...

  12. Governing from Above : Solid Waste Management in Nigeria's New Capital City of Abuja

    OpenAIRE

    Adama, Onyanta

    2007-01-01

    This doctoral dissertation examines how the symbolic character of a relocated capital city influences and intersects with local conditions to shape the governance structure and relations in service delivery. The focus is on Abuja, the new capital city of Nigeria, and the sector studied is solid waste management. Abuja was planned to avoid the numerous problems facing other Nigerian cities. Contrary to the intention of government and planners, the city now houses the fastest growing slum in th...

  13. What would it take to achieve the Paris temperature targets?

    Science.gov (United States)

    Sanderson, Benjamin M.; O'Neill, Brian C.; Tebaldi, Claudia

    2016-07-01

    The 2015 Paris Agreement aims to limit warming to 2 or 1.5°C above preindustrial level, although combined Intended Nationally Determined Contributions (INDCs) are likely insufficient to achieve these targets. We propose a set of idealized emission pathways consistent with the targets. If countries reduce emissions in line with their INDCs, the 2°C threshold could be avoided only if net zero greenhouse gas emissions (GHGEs) are achieved by 2085 and late century negative emissions are considerably in excess of those assumed in Representative Concentration Pathway (RCP) 2.6 (net -5 Gt CO2/yr, compared with -1.5 Gt CO2/yr in RCP2.6). More aggressive near-term reductions would allow 2°C to be avoided with less end-of-century carbon removal capacity. A 10% cut in GHGEs by 2030 (relative to 2015) could likely achieve 2°C with RCP2.6 level negative emissions. The 1.5°C target requires GHGEs to be reduced by almost a third by 2030 and net zero by 2050, while a 50 year overshoot of 1.5°C allows net zero GHGEs by 2060.

  14. Clinical and Demographic Characteristics of Women with Intrauterine Adhesion in Abuja, Nigeria

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    Efena R. Efetie

    2012-01-01

    Full Text Available Objective. Infertility menstrual abnormalities continue to constitute a significant bulk of gynecological consultation in Africa. Both of these problems are sometimes traced to intrauterine adhesions which are preventable in the majority of cases. Study Design. A retrospective analysis of intrauterine adhesions at the National Hospital Abuja, Nigeria, was carried out, covering the period from 1st September 1999 to 1st September 2004. A total of 72 cases were analyzed. Statical analysis was done using 2. Results. The incidence of intrauterine adhesions was 1.73% of new patients. Mean age ± SD was 29.97±4.82 years. Patients who were Para 0 to 1 constituted 81.9% of the total. Intrauterine adhesions significantly (<0.02 occurred in nulliparae. The majority (68% were educated only up to secondary level which was significant (<0.05. Menstrual abnormalities were present in 90.3%. The commonest predisposing factor identified was a history of dilatation and curettage or uterine evacuation. Conclusion. Intrauterine adhesions are associated with lower educational status and low parity. Increasing educational targets nationally, poverty alleviation, nationwide retraining in manual vacuum aspiration, and wider application of this technique are recommended.

  15. CHARACTERIZATION OF EXTERNAL INDUCED CORROSION DEGRADATION OF AJAOKUTA-ABUJA GAS PIPELINE SYSTEM, NIGERIA

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    ADEDIPE OYEWOLE

    2011-11-01

    Full Text Available Characterization of External Induced corrosion degradation of Ajaokuta- Abuja gas pipeline system was successfully carried out. The objective of this work is to analyze the mechanism of corrosion, analyze the effect of the corrosion on oil and gas pipeline and to evaluate the corrosion potential of a pipeline route. These were achieved by carrying out resistivity experiment on every one kilometer on the right of way (ROW of the pipeline. Soil and water aggressiveness test was also carried out on soil and water sample of the pipeline route respectively. The resistivity result was considerably high, chemical analysis revealed that the soil and wateracidity is between the pH of 6.7 and 8.2 respectively, which is moderately alkaline in nature, which makes the soil environment not conducive for pipelines due to potential for corrosion attack. The chloride content of the soil and water were also high. Based on the experimental results, it was proposed that the pipe should be laid on2-5m below the ground and that the galvanic anode for cathodic protection be located 1m below the ground, in order to avoid corrosion. It is therefore necessary to note that characterization of external corrosion is quite different from internal pipeline corrosion characterization.

  16. Managing Pre-Construction and Construction Risks on Project Sites in Abuja-Nigeria

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    Jimoh R.A.

    2016-03-01

    Full Text Available Managing risks in construction projects has been acknowledged as a key direction process for the purposes of attaining the project goal in terms of time, cost, quality, safety, and environmental sustainability. Hence, the paper evaluated pre-construction and construction risks on active project sites in Abuja-Nigeria. This was achieved using survey method through the self-administration of 35 questionnaires to the professionals handling the 35 identified projects being undertaking at that time. Results showed that errors and omissions in design and improperly defined project scope had mean score values of 3.03 and 2.54, respectively, were the construction risks most experienced by the professionals during pre-construction. On the other hand, fluctuation in market prices and delays with mean score values of 3.14 and 2.74, respectively, were the construction risks experienced by the professionals during the construction phase of the projects. It is recommended that procurement methods such as construction management should be adopted and stakeholders should keep to their own side of the bargain to avoid unnecessary delays.

  17. Evaluation of background ionising radiation levels within Gwagwalada town, Abuja

    International Nuclear Information System (INIS)

    The background ionising radiation levels within Gwagwalada Town, Abuja has been carried out using Atomtex 1117M Radiation Monitor. Readings were taken in twelve different locations. Twenty different readings were taken at each location and the mean equivalent dose rate was used to calculate the annual equivalent dose rate. A total of 240 measurements were taken across the 12 locations in the study Area. It was observed that the average dose equivalent varied from 0.105±0.008 μSv/h to 0.114±0.015μSv/h with a mean of 0.109±0.013 μSv/h. The mean value from Ungwan Bassa shows the highest equivalent dose rate while the equivalent dose rate from Phase 3 was the lowest. Ungwan Dodo, Ungwan Gwari recorded the second and third highest in-situ gamma radiation of 0.113±0.013 μSv/h and 0.112±0.012 μSv/h respectively. The result shows that the entire equivalent dose rates of all the locations were below the value of the Standard Background Radiation of 0.133 μSv/h. The study also revealed that the average annual equivalent dose rate is 0.192±0.005 mSv/y which is lower than the value of 1.0 mSv/yr averaged over five consecutive years according to the dose limit recommended by the International Commission on Radiological Protection (ICRP).

  18. GHG emission reductions and costs to achieve Kyoto target

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Emission projection and marginal abatement cost curves (MACs) are the central components of any assessment of future carbonmarket, such as CDM (clean development mechanism) potentials, carbon quota price etc. However, they are products of very complex,dynamic systems driven by forces like population growth, economic development, resource endowments, technology progress and so on. Themodeling approaches for emission projection and MACs evaluation were summarized, and some major models and their results were compared.Accordingly, reduction and cost requirements to achieve the Kyoto target were estimated. It is concluded that Annex I Parties' total reductionrequirements range from 503-1304 MtC with USA participation and decrease significantly to 140-612 MtC after USA' s withdrawal. Totalcosts vary from 21-77 BUSD with USA and from 5-36 BUSD without USA if only domestic reduction actions are taken. The costs wouldsharply reduce while considering the three flexible mechanisms defined in the Kyoto Protocol with domestic actions' share in the all mitigationstrategies drops to only 0-16%.

  19. Achieving blood pressure targets with the perindopril/amlodipine combination

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    Ljevar Veronika

    2013-05-01

    Full Text Available Elevated blood pressure (BP is one of the most important risk factors for cardiovascular (CV morbidity and mortality, and BP lowering is associated with reduction of coronary events. Despite this, less than one-third of hypertensive patients in Europe have adequate BP control. Improvement of the rates of adequate BP control and thereby a reduction of CV morbidity and mortality, currently represent a major challenge in the daily clinical practice. Many patients require two or more antihypertensives to achieve guideline-recommended BP targets. Findings from different studies have demonstrated that the fixed-dose combination (FDC perindopril/amlodipine is an effective and well tolerated treatment in patients uncontrolled with monotherapy, and in patients inadequately managed on another combination therapy. The perindopril/amlodipine FDC provides good rates of BP control in daily clinical practice. These good rates of BP control could be ex- plained by the synergistic mode of action of the two components, leading to enhanced BP lowering and reduced side effects, which may have a positive impact on treatment adherence. Krka’s perindopril/amlodipine FDC is available in the full range of doses, providing a flexible and effective treatment of hypertension.

  20. Contributions of Vehicular Traffic to Carbon Dioxide Emissions in Kaduna and Abuja, Northern Nigeria

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    Peter Ndoke NDOKE

    2006-07-01

    Full Text Available The quantity of carbon dioxide (CO2 contributed by automobile emissions to the environment was determined at some areas in Kaduna and Abuja in Northern Nigeria. Five census stations were selected in each of the two towns. In Kaduna, Jabi road in Ungwan Rimi, Kawo Motor park, Stadium round-about, Sabo and Kasuwa (Kaduna Main Market, were selected, while Asokoro (behind ECOWAS, Area One junction, A.Y.A. junction, Wuse market bus-stop, and Mabushi round-about were selected for Abuja. A gas sampling pump and tubes that could detect carbon dioxide were used to detect the quantity of CO2 in the environment at a certain time. The results obtained show a variation in the amount of CO2 in the environment. Areas with relatively heavy congestion show a high concentration of CO2, while areas with minimal traffic show a lower concentration of CO2. Sabo in Kaduna has an average concentration of 1840 ppm being the highest, while Asokoro (behind ECOWAS, Abuja has the least average concentration of 1160 ppm. Review of literature showed that increasing CO2 levels have adverse effects such as the Greenhouse Effect, which may lead to Global Warming, as well as a number of other climatic events. These concentrations are still not high enough to cause any serious health effects but they provide a baseline study for Policy makers and Town planners.

  1. Therapeutic Target Achievement in Type 2 Diabetic Patients after Hyperglycemia, Hypertension, Dyslipidemia Management

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    Ah Young Kang

    2011-06-01

    Full Text Available BackgroundOur study group established "3H care" in 2002. The meaning of "3H care" attain and maintain adequate controls over hypertension, hyperlipidemia, and hyperglycemia in type 2 diabetic patients. This study evaluated the achievement of target goals after one year or more of "3H care" by specialists in our diabetic clinic.MethodsThis was a retrospective study of 200 type 2 diabetic patients who received "3H care" for one year or more in our diabetic clinic. We evaluated achievement of target goals for metabolic controls as suggested by the American Diabetes Association.ResultsOverall, 200 type 2 diabetes patients were enrolled, of whom 106 were males (53% and 94 were females (47%. After one year of "3H care," the mean HbA1c was 7.2±1.5% and the percentage of patients achieving glycemic control (HbA1c <7% was 51.8%. However only 32.2% of hypertensive patients achieved the recommended target. After one year of "3H care," the percentages of those who achieved the target value for dyslipidemia were 80.0% for total cholesterol, 66.3% for low density lipoprotein cholesterol, 57.9% for triglyceride, and 51.8% for high density lipoprotein cholesterol. The percentage that achieved all three targets level was only 4.4% after one year and 14.8% after two years.ConclusionThe results of this study demonstrate that only a minor proportion of patients with type 2 diabetes achieved the recommended goals despite the implementation of "3H care." It is our suggestion that better treatment strategies and methods should be used to control hypertension, hyperlipidemia and hyperglycemia.

  2. COMBINATION THERAPY OF HYPERTENSION — A RELIABLE WAY TO TARGET ACHIEVE

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    Yu. V. Lukina

    2010-01-01

    Full Text Available Data of evidence-based cardiology and clinical guidelines that define the position of combined therapy to achieve the targets of hypertension (HT treatment (achievement and maintenance of the target blood pressure (BP level, protection of the target organs, improvement of the quality of life in hypertensive patients are presented in the article. The advantages of rational combined therapies (potentiation of antihypertensive effect, reduction of a number of adverse events are considered. Studies of therapeutic efficacy and safety of combined antihypertensive therapy based on generics are important. The advantages of combined therapy in achievement of target BP levels are presented on example of comparative study of new generic and original amlodipine in patients with HT of 1-2 degrees. Target BP level was reached respectively in 90% and 97% of patients with HT in groups of generic and original amlodipine combined with generic lisinopril and hydrochlorothiazide. Safety profile was acceptable. This confirms the high efficacy of amlodipine + lisinopril + hydrochlorothiazide combination, including one on the basis of generics.

  3. A method to achieve rapid localised deep heating in a laser irradiated solid density target

    CERN Document Server

    Schmitz, Holger

    2016-01-01

    Rapid heating of small buried regions by laser generated fast electrons may be useful for applications such as XUV radiation sources or as drivers for shock experiments. In non-structured targets the heating profile possesses a global maximum near the front surface. This paper presents a new target design that uses resistive guiding to concentrate the fast electron current density at a finite depth inside the target. The choice of geometry uses principles of non-imaging optics. A global temperature maximum at depths up to 50{\\mu}m into the target is achieved. Although theoretical calculations suggest that small source sizes should perform better than large ones, simulations show that a large angular spread at high intensities results in significant losses of the fast electrons to the sides. A systematic parameter scan suggests an optimal laser intensity. A ratio of 1.6 is demonstrated between the maximum ion temperature and the ion temperature at the front surface.

  4. The Impact of Home Environment Factors on Academic Performance of Senior Secondary School Students in Garki Area District, Abuja - Nigeria

    OpenAIRE

    L. T. Dzever

    2015-01-01

    The study examined the impact of home environment factors on the academic performance of public secondary school students in Garki Area District, Abuja, Nigeria. The stratified sampling technique was used to select 300 students from six public schools, while the simple random sampling technique was used to administer the questionnaire. The study utilized a descriptive survey research design for the study. Also, data on student’s academic performance was obtained from student’s scores in four ...

  5. Average Minimum Transmit Power to achieve SINR Targets: Performance Comparison of Various User Selection Algorithms

    CERN Document Server

    Salim, Umer

    2010-01-01

    In multi-user communication from one base station (BS) to multiple users, the problem of minimizing the transmit power to achieve some target guaranteed performance (rates) at users has been well investigated in the literature. Similarly various user selection algorithms have been proposed and analyzed when the BS has to transmit to a subset of the users in the system, mostly for the objective of the sum rate maximization. We study the joint problem of minimizing the transmit power at the BS to achieve specific signal-to-interference-and-noise ratio (SINR) targets at users in conjunction with user scheduling. The general analytical results for the average transmit power required to meet guaranteed performance at the users' side are difficult to obtain even without user selection due to joint optimization required over beamforming vectors and power allocation scalars. We study the transmit power minimization problem with various user selection algorithms, namely semi-orthogonal user selection (SUS), norm-based...

  6. Household waste management in Copenhagen A solution for achievement of the EU’s recycling target

    OpenAIRE

    Dao Thi Thu Huong, Diu

    2014-01-01

    The overall aim of this thesis is to identify the best solution for the Copenhagen’s household waste handling to achieve the recycling target of 45% and 50% in 2018 and 2022. Accordingly, the analyses in terms of recycling ratios and costs based on 3 household waste handling scenarios including the Renescience scenario, the Aikan scenario and the manure based biogas scenario are carried out. Among these scenarios, the Renescience scenario is in association with mixed collection of bio-waste i...

  7. Achievement of cardiovascular risk factor targets in young adults with diabetes mellitus

    OpenAIRE

    DONOVAN, PETER J.; H David McIntyre

    2010-01-01

    Peter J Donovan, H David McIntyreDepartment of Endocrinology, Mater Health Services, Mater Clinical School, The University of Queensland School of Medicine, South Brisbane, QLD, AustraliaBackground: Many patients with diabetes mellitus fail to achieve treatment targets recommended in recognized guidelines. Little data is available in this area relating to young adults.Objective: To assess whether treatment goals for glycosylated hemoglobin (HbA1c), blood pressure, lipid-lowering, and process ...

  8. Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos

    International Nuclear Information System (INIS)

    This work represents the first guide for using steric-block antisense oligos as tools for effective and targeted modification of RNA splicing. Comparison of several steric-block oligo types shows the properties of Morpholinos provide significant advantages over other potential splice-blocking oligos. The procedures and complications of designing effective splice-blocking Morpholino oligos are described. The design process requires complete pre-mRNA sequence for defining suitable targets, which usually generate specific predictable messengers. To validate the targeting procedure, the level and nature of transcript alteration is characterized by RT-PCR analysis of splice modification in a β-globin splice model system. An oligo-walking study reveals that while U1 and U2 small nuclear RiboNucleoProtein (snRNP) binding sites are the most effective targets for blocking splicing, inclusion of these sites is not required to achieve effective splice modifications. The most effective targeting strategy employs simultaneously blocking snRNP binding sites and splice-junctions. The work presented here continues to be the basis for most of the successful Morpholino oligos designed for the worldwide research community to block RNA splicing

  9. ACHIEVING LIPID TARGETS IN ADULTS WITH TYPE 2 DIABETES--THE SANDS STUDY

    Science.gov (United States)

    Russell, Marie; Silverman, Angela; Fleg, Jerome L.; Lee, Elisa T.; Mete, Mihriye; Weir, Matthew; Wilson, Charlton; Yeh, Fawn; Howard, Barbara V.; Howard, Wm. James

    2010-01-01

    Background Although lipid management in diabetes is standard practice, goals often are neither met nor maintained. Strategies for achieving lower targets have not been explored. The Stop Atherosclerosis in Native Diabetics Study (SANDS) randomized patients with diabetes to standard versus aggressive lipid and blood pressure goals for 36 months. Objective To report strategies used to achieve and maintain lipid goals and to report adverse events (AEs). Methods Adults with type 2 diabetes and no history of cardiovascular disease (N=499) were randomized to standard (low-density lipoprotein cholesterol [LDL-C]≤100 mg/dL, non-high-density lipoprotein cholesterol [non-HDL-C]≤130 mg/dL) or aggressive (LDL-C≤70 mg/dL, non-HDL-C≤100 mg/dL) targets. An algorithm started with statin monotherapy, adding intestinally acting agents as required to reach LDL-C targets. Triglyceride [TG]-lowering agents were next used to reach non-HDL-C goals. Lipid management was performed by mid-level practitioners, with physician consultation, using point-of-care lipid determinations. Results On average, both groups achieved the LDL-C and non-HDL-C goals within 12 months and maintained them throughout the study. At 36 months, mean (SD) LDL-C and non-HDL-C were 72 (24) and 102 (29) mg/dL in the aggressive group (AGG) and 104 (20) and 138 (26) mg/dL, respectively, in the standard group (STD); systolic blood pressure targets were 115 and 130 mmHg, respectively. 68% of participants reached target LDL-C for >50% of the visits and 46% for >75% of visits. At 36 months, the AGG averaged 1.5 lipid lowering medications and the STD 1.2. Statins were used in 91% and 68% of the AGG and STD; ezetimibe by 31% and 10%; fibrates by 8% and 18%. No serious adverse events (SAEs) were observed; AEs occurred in 18% of the AGG and 14% of the STD. Conclusion Standard and aggressive lipid targets can be safely maintained in diabetic patients. Standardized algorithms, point-of-care lipid testing, and non

  10. Why use of interventions targeting outdoor biting mosquitoes will be necessary to achieve malaria elimination

    Directory of Open Access Journals (Sweden)

    Nicodem James Govella

    2012-06-01

    Full Text Available By definition, elimination of malaria means permanent reduction to zero of locally incidence of infections. Achieving this goal among other reasons, it requires fully understanding on where and when persons are most exposed to malaria vectors as these are fundamental for targeting interventions to achieve maximum impact. While elimination can be possible in some settings with low malaria transmission intensity and dominated with late and indoor biting of vectors using Long Lasting Insecticidal Nets (LLIN and Indoor Residual Spraying (IRs, it’s difficult and even impossible in areas with high and where majority of human exposure to transmission occurs outside human dwellings. Recently in response to wide spread use of LLIN and IRS, human risk of exposure to transmission is increasingly spread across the entire night so that much of it occurs outdoors and before bed time. This modification of vector populations and behaviour has now been reported from across Africa, Asia and from the Solomon Islands. Historical evidence shows that even in areas with intervention coverage exceeding 90% of human population it was so hard to even push prevalence down below the pre elimination threshold of 1% being compromised mainly with the outdoor residual transmission. Malaria control experts must however continue to deliver interventions that tackle indoor transmission but considerable amount of resources that target mosquitoes outside of houses and outside of sleeping hours will therefore be required to sustain and go beyond existing levels of malaria control and achieve elimination.

  11. Risk factors that affect reproductive target achievement in fertile dairy cows.

    Science.gov (United States)

    Aungier, S P M; Roche, J F; Diskin, M G; Crowe, M A

    2014-01-01

    The aims of the present study were to investigate (1) the risk factors that influence the achievement of reproductive targets postpartum (pp) and (2) the key factors that influence pregnancy rate following first artificial insemination (AI) in dairy cows. Ninety-eight Holstein-Friesian pp cows were blood sampled from wk 1 to 4 pp for hematology and biochemistry. Reproductive tract health was assessed weekly by ultrasonography and vaginal mucus scoring. Body condition score (BCS), lameness score, and milk yield were assessed every 2 wk. Milk samples for progesterone assay were collected twice weekly and on d 4, 5, and 7 after AI. Risk factors associated with achieving reproductive targets depended on (1) increased metabolic activity of the liver (increased glutamate dehydrogenase at calving and increased γ-glutamyl transpeptidase in wk 4), (2) a competent immune system (increased neutrophils in wk 1; decreased α1-acid glycoprotein in wk 1, 2, and 3), (3) an endocrine system that was capable of responding by producing sufficient triiodothyronine in wk 2 and increased insulin-like growth factor I in wk 3 and 4, (4) a lower negative energy balance status (decreased nonesterified fatty acid concentration in wk 1; decreased β-hydroxybutyrate concentration in wk 2; BCS loss between calving and d 28 pp factors that increased the odds of a successful first AI were previous ovulation(s) (odds ratio=3.17 per ovulation), BCS >2.5 at AI (odds ratio=3.01), and clear vaginal mucus (score=0) compared with purulent mucus (score >0) 4 d after first AI (odds ratio=2.99). In conclusion, this study identified key risk factors in the early pp period that give a higher probability of cows achieving their reproductive targets and of having a first-AI pregnancy. PMID:24679929

  12. Effects of gamma irradiation on fungal load and Mycotoxin on Sesame seeds in Abuja, Nigeria

    International Nuclear Information System (INIS)

    Gamma rays of average energy of 1.25 MeV from radionuclide 60Co was used in this study and the effects of varying doses 3, 6, 9, 12, 15 kGy on fungal load of and mycotoxin content on sesame seeds were investigated. Sesame seed samples were collected from Abaji, Gwagwalada, Kubwa and Karu markets in Abuja, Federal Capital Territory, Nigeria. A serial dilution technique was employed and the fungi so diluted from the sesame seed samples were identified based on micro and macro morphological characteristics. The Aflatoxin Total and Ochratoxin A Contents in the samples were analysed using AgraQaunt direct combative enzyme-linked immunosorbent assay (ELISA). In all, 157 fungal isolates to four genera: Aspergillus, Curvularia, Penicillium, and Fusarium spp. in decreasing order of predominance were identified. Aspergillus spp. were observed from all the nonirradiated samples. Doses of 6-15kGy eliminated the entire fungal load. Also doses of 9-15kGy generally reduced Ochratoxin A content in all the samples, the rate of mycotoxin reduction was inconsistent with absorbed dose. However, sesame seed samples from the four markets exposed to irradiation dose of 15kGy had the comparatively least Aflatoxin Total content.

  13. Aetiology and presentation of ankylosis of the temporomandibular joint: report of 23 cases from Abuja, Nigeria.

    Science.gov (United States)

    Bello, Seidu Adebayo; Aluko Olokun, Bayo; Olaitan, Abayomi Ademola; Ajike, Sunday O

    2012-01-01

    Several studies have reviewed the management of ankylosis of the temporomandibular joint (TMJ), but only a few focused on the aetiology and clinical features. We retrospectively studied the aetiology and clinical features of patients with ankylosis of the TMJ who presented to the Maxillofacial Unit, National Hospital, Abuja, Nigeria, between 2004 and 2009. There were 13 male and 10 female patients, M:F ratio 1.3:1, age range 6-62, mean (SD) 20 (13) years. The aetiological factors were trauma (n=11) that comprised falls (n=6), untreated fractures of the zygomatic arch (n=4) and myositis ossificans (n=1); infection (n=9), that comprised cancrum oris (n=3) and ear infection (n=6); congenital or unknown (n=2), and coronoid hyperplasia (n=1). The maximum interincisal distance at presentation ranged from 0 to 25 mm (mean (SD) 6.7 (7.2) mm). Seventeen had facial deformities. The diagnoses recorded were as follows: left extracapsular ankylosis, (n=8); right intracapsular bony ankylosis, (n=6); left intracapsular bony ankylosis, (n=4); bilateral intracapsular bony ankylosis, (n=4), and bilateral intracapsular fibrous ankylosis (n=1). Extreme poverty was the main predisposing factor. There is a need for a concerted effort among healthcare providers, policy makers, and the world in general to eradicate poverty and improve healthcare to limit the incidence of ankylosis of the TMJ.

  14. Comparison of public and private school teachers and school principals’ opinions in Abuja, Nigeria

    Directory of Open Access Journals (Sweden)

    Deniz Ozcan

    2015-01-01

    Full Text Available This study aims to examine public and private school teachers’ opinions on different aspects of their professional associations and provisions and also asks principals about teachers’ conduct and their views on the Nigerian curriculum. To conduct this study, qualitative and quantitative research models were used to investigate differences between the two organizations. Quantitative data was collected by distributing questionnaires to 118 teachers in the Abuja Municipal Area Council (AMAC, Nigeria. To conduct the qualitative analysis, 15 teachers from two schools were selected (a total of 30 teachers to answer 5 discussion questions concerning their views on the Nigerian educational system. The findings revealed that private school teachers are at an advantage when it comes to provision of resources and technology, professional development and to some degree salaries. Both public and private school teachers felt being a teacher did not bring them respect in their community. Government policy makers need to study private schools and how they operate to see how they can make changes to produce the revolutionary reform needed in education. 30 principals’ interviews revealed that public school teachers are not easily held accountable for misconduct due to the structure of leadership, while private school teachers are held accountable and any form of unprofessionalism easily leads to termination of employment.

  15. Assessment of antimicrobial drug residues in beef in Abuja, the Federal Capital Territory, Nigeria.

    Science.gov (United States)

    Omeiza, Gabriel K; Ajayi, Itopa E; Ode, Okwoche J

    2012-01-01

    Drugs administered to food-producing animals close to the time of slaughter often result in prohibited antimicrobial residues in the animal tissues at slaughter. Evidence based on the Premi® test confirmed the occurrence of antimicrobial drug residues in 89.3% of kidney and urine samples from cattle slaughtered within Abuja town where the residents rely heavily on beef as a source of protein. The administration of antibiotics close to the time of slaughter by marketers/herd owners and transporters was found to be significantly (p<0.05) higher when compared with butchers and abattoir workers. The practice of administering antibiotics to animals close to the time of slaughter was believed to be profit-motivated. The research suggests that awareness campaigns amongst the stakeholders, the enactment of appropriate laws for the control of antibiotic use and the empowerment of veterinary public health practitioners in food regulatory agencies as some of the strategies which may positively reduce the risk of antimicrobial drug residues in food animals in Nigeria. PMID:23038074

  16. Categorisation Of Clay Deposits In The Federal Capital Territory Of Abuja

    Directory of Open Access Journals (Sweden)

    Manukaji John U.

    2013-03-01

    Full Text Available Clay deposits in the Federal Capital Territory of Abuja were investigated with a view to categorizing them in order to determine their suitability as insulating refractory material. Thesamples were collected from three different locations in the territory, namely Sheda, Abaji and Karimu, and labeled A, B, and C. In order toproject a better representation of the territory, the samples were mined from ten cites each. The mined clay samples from the ten cites were mixed properly and a representative specimen for test from that location was produced using the cone and quartering system as recommended by the American Society of Testing Materials (ASTM. Atomic Absorption Spectrometer(AAS was used to determine the chemical composition, while other established processes were used to determine other insulating properties likeparticle size distribution, specific gravity, bulk density, solid density, water absorption, apparent porosity, permeability to air, refractoriness, thermal shock resistance, modulus of rupture, linear shrinkage and thermal conductivity. The chemical analysis showed that all the samples had high percentages of silica and alumina, thereby classifying them as Alumino-silicates.

  17. EFFICACY OF COMBINED ANTIHYPERTENSIVE THERAPY IN ACHIEVEMENT OF TARGET BLOOD PRESSURE IN DIABETIC PATIENTS

    Directory of Open Access Journals (Sweden)

    O. A. Koshel'skaya

    2012-01-01

    Full Text Available Aim. To evaluate the efficacy of long-term combined antihypertensive therapy (AHT based on renin-angiotensin-aldosterone system (RAAS blockers, indapamide and calcium channel blocker (CCB in hypertensive patients with diabetes mellitus (DM in accordance with target blood pressure (BP <130/80 mm Hg achievement rate, dynamics of 24-hour BP profile, metabolic indices, and local stiffness of the main arteries. Besides, to study the effects of the CCB addition to dual therapy on these parameters. Material and methods. Patients (16 men, 31 women, 57.2±6.6 years old with arterial hypertension degrees 1–3 and mild to moderate DM type 2 were included into the study. The patients were treated with perindopril (5–10 mg/day or valsartan (80–160 mg/day in combination with indapamide SR (1.5 mg/day and amlodipine (5–10 mg/day. Examination included office BP measurement and ambulatory BP monitoring (ABPM, common carotid arteries sonarography , evaluation of serum levels of potassium, creatinine, uric acid, glucose metabolism and lipid profile parameters, calculation of insulin resistance index (HOMA at baseline and after 30–32 weeks of treatment. Results. Target BP was achieved in 86.7% of patients. Evenly reduction of day and night BP without reflex tachycardia and hypotension episodes was observed. Office BP decreased from 149.5±12.0/90.0±8.3 to 125.0±7.6/76.8±4.9 mm Hg (p<0.05 and average daily BP (ABPM decreased to 120.1±10.0/71.7±6.9 mmHg. Three drugs were needed to achieve target BP in baseline systolic BP >150 mm Hg (office or >134 mmHg (ABPM. Marked beneficial effect on the morphological and functional characteristics of the vascular wall and its elastic properties, improvement of glycemic control, tissue insulin sensitivity and lipids profile were found. These effects were associated mainly with amlodipine inclusion into the therapy. Conclusion. The combined AHT based on RAAS blockers, indapamide SR and CCB provides achievement of

  18. EFFICACY OF COMBINED ANTIHYPERTENSIVE THERAPY IN ACHIEVEMENT OF TARGET BLOOD PRESSURE IN DIABETIC PATIENTS

    Directory of Open Access Journals (Sweden)

    O. A. Koshel'skaya

    2015-12-01

    Full Text Available Aim. To evaluate the efficacy of long-term combined antihypertensive therapy (AHT based on renin-angiotensin-aldosterone system (RAAS blockers, indapamide and calcium channel blocker (CCB in hypertensive patients with diabetes mellitus (DM in accordance with target blood pressure (BP <130/80 mm Hg achievement rate, dynamics of 24-hour BP profile, metabolic indices, and local stiffness of the main arteries. Besides, to study the effects of the CCB addition to dual therapy on these parameters. Material and methods. Patients (16 men, 31 women, 57.2±6.6 years old with arterial hypertension degrees 1–3 and mild to moderate DM type 2 were included into the study. The patients were treated with perindopril (5–10 mg/day or valsartan (80–160 mg/day in combination with indapamide SR (1.5 mg/day and amlodipine (5–10 mg/day. Examination included office BP measurement and ambulatory BP monitoring (ABPM, common carotid arteries sonarography , evaluation of serum levels of potassium, creatinine, uric acid, glucose metabolism and lipid profile parameters, calculation of insulin resistance index (HOMA at baseline and after 30–32 weeks of treatment. Results. Target BP was achieved in 86.7% of patients. Evenly reduction of day and night BP without reflex tachycardia and hypotension episodes was observed. Office BP decreased from 149.5±12.0/90.0±8.3 to 125.0±7.6/76.8±4.9 mm Hg (p<0.05 and average daily BP (ABPM decreased to 120.1±10.0/71.7±6.9 mmHg. Three drugs were needed to achieve target BP in baseline systolic BP >150 mm Hg (office or >134 mmHg (ABPM. Marked beneficial effect on the morphological and functional characteristics of the vascular wall and its elastic properties, improvement of glycemic control, tissue insulin sensitivity and lipids profile were found. These effects were associated mainly with amlodipine inclusion into the therapy. Conclusion. The combined AHT based on RAAS blockers, indapamide SR and CCB provides achievement of

  19. Seropositivity ofChlamydophila pneumoniae immunoglobulin G antibody of HIV/AIDS patients in Abuja, Nigeria

    Institute of Scientific and Technical Information of China (English)

    Yakubu Boyi Ngwai; Izebe KS; Ijele IG; Ishaleku D; Inyang US

    2010-01-01

    Objective:To detect IgG antibody toChlamydophila pneumoniae(CP)in sera ofHIV/AIDS patients and provide rationale for inclusion of routine screening for anti-CP antibodies and anti-chlamydial agents in the Nigerian NationalHIV/AIDS Management Plan.Methods: Serum samples from34 consentingHIV/AIDS patients attended a Government-approved Antiretroviral Treatment Facility in Abuja were screened by enzyme-linked immunosorbent assay for anti-CP IgG antibody using ImmunoComb® Chlamydia Bivalent IgG Test kit (Orgenics, Israel).Results:Anti-CP IgG antibody was detected in20 (58.8%)of34 patients tested. The detection rate was higher among the males(8/13; 61.5%) than the females (12/21; 57.1%). Patients of the age group 16-30 years had the highest(7/10; 70%) detection of anti-CP IgG antibody.Conclusions:The result of the present study suggests the presence of anti-CP antibodies in sera of the HIV/AIDS patients, and reinforces the need for routine screening for anti-CPantibodies as a necessary intervention to reduce the burden ofChlamydophila pneumoniae (C. pneumoniae) infections and to reduceHIV-positive morbidity in Nigeria. The outcome of this study also provides justification for the possible inclusion of anti-chlamydial agents in the NationalHIV/AIDS Management Plan to provide prophylaxis against or treat activeC. pneumoniae infections.

  20. Comparative Analysis of Cooperative and Non-cooperative Farmers’ access to Farm Inputs in Abuja, Nigeria

    Directory of Open Access Journals (Sweden)

    Julius Ajah

    2015-02-01

    Full Text Available Access to farm inputs is one of the major challenges facing rural farmers in Nigeria. To alleviate this problem, government at different levels strongly recommended the formation of cooperative societies to farmers. Against this background, a study was conducted to determine if differential access to farm inputs exists between cooperative and non-cooperative farmers in Abuja, Nigeria. A multi-stage technique was used for sample selection while semi-structured questionnaires were used for data collection. A total of 360 farmers were randomly interviewed in four agricultural zones (180 cooperative and 180 non-cooperative farmers. Data were analyzed using two-way factorial analysis of variance (ANOVA and mean separation was done at 5% probability level. Results revealed that there was significant difference (P < 0.01 in cooperative and non-cooperative farmers’ access to farm inputs. Comparatively, the mean perceptions indicated that the cooperative farmers had more access to labour, loan, herbicide, insecticide, rodenticide, fertilizer, tractor services, storage equipment and processing equipment while the non-cooperative farmers had more access to land. The results also indicated that the most accessible farm input to both cooperative and non-cooperative farmers was land while the least accessible farm inputs were loan and tractor services. Based on the findings, the paper concluded that differential access to farm inputs existed between cooperative and non-cooperative farmers in the study area. It was recommended that government and non-governmental agencies should encourage farmers to form and/or join viable cooperative societies.Key words: cooperative societies, least accessible farm inputs, mean perception, most accessible farm input, small-scale farmers, 

  1. Optimal models with maximizing probability of first achieving target value in the preceding stages

    Institute of Scientific and Technical Information of China (English)

    林元烈; 伍从斌; 康波大

    2003-01-01

    Decision makers often face the need of performance guarantee with some sufficiently high proba-bility. Such problems can be modelled using a discrete time Markov decision process (MDP) with a probabilitycriterion for the first achieving target value. The objective is to find a policy that maximizes the probabilityof the total discounted reward exceeding a target value in the preceding stages. We show that our formula-tion cannot be described by former models with standard criteria. We provide the properties of the objectivefunctions, optimal value functions and optimal policies. An algorithm for computing the optimal policies forthe finite horizon case is given. In this stochastic stopping model, we prove that there exists an optimal deter-ministic and stationary policy and the optimality equation has a unique solution. Using perturbation analysis,we approximate general models and prove the existence of ε-optimal policy for finite state space. We give anexample for the reliability of the satellite systems using the above theory. Finally, we extend these results tomore general cases.

  2. Systematic procedure for generating operational policies to achieve target crystal size distribution (CSD) in batch cooling crystallization

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli; Singh, Ravendra; Sin, Gürkan;

    2011-01-01

    A systematic procedure to achieve a target crystal size distribution (CSD) under generated operational policies in batch cooling crystallization is presented. An analytical CSD estimator has been employed in the systematic procedure to generate the necessary operational policies to achieve the ta...

  3. International target values 2010 for achievable measurement uncertainties in nuclear material accountancy

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Fabio C., E-mail: fabio@ird.gov.b [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Almeida, Silvio G. de; Renha Junior, Geraldo, E-mail: silvio@abacc.org.b, E-mail: grenha@abacc.org.b [Agencia Brasileiro-Argentina de Contabilidade e Controle de Materiais Nucleares (ABACC), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    The International Target Values (ITVs) are reasonable uncertainty estimates that can be used in judging the reliability of measurement techniques applied to industrial nuclear and fissile materials subject to accountancy and/or safeguards verification. In the absence of relevant experimental estimates, ITVs can also be used to select measurement techniques and calculate sample population during the planning phase of verification activities. It is important to note that ITVs represent estimates of the 'state-of-the-practice', which should be achievable under routine measurement conditions affecting both facility operators and safeguards inspectors, not only in the field, but also in laboratory. Tabulated values cover measurement methods used for the determination of volume or mass of the nuclear material, for its elemental and isotopic assays, and for its sampling. The 2010 edition represents the sixth revision of the International Target Values (ITVs), issued by the International Atomic Energy Agency (IAEA) as a Safeguards Technical Report (STR-368). The first version was released as 'Target Values' in 1979 by the Working Group on Techniques and Standards for Destructive Analysis (WGDA) of the European Safeguards Research and Development Association (ESARDA) and focused on destructive analytical methods. In the latest 2010 revision, international standards in estimating and expressing uncertainties have been considered while maintaining a format that allows comparison with the previous editions of the ITVs. Those standards have been usually applied in QC/QA programmes, as well as qualification of methods, techniques and instruments. Representatives of the Brazilian Nuclear Energy Commission (CNEN) and the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) participated in previous Consultants Group Meetings since the one convened to establish the first list of ITVs released in 1993 and in subsequent revisions

  4. Stroke risk factors, subtypes, and 30-day case fatality in Abuja, Nigeria

    Directory of Open Access Journals (Sweden)

    Nura H Alkali

    2013-01-01

    Full Text Available Background: Stroke is the second leading cause of death and the leading cause of adult disability worldwide. A better understanding of stroke risk factors and outcome may help guide efforts at reducing the community burden of stroke. This study aimed to understand stroke risk factors, imaging subtypes, and 30-day outcomes among adult Nigerians. Materials and Methods: We prospectively recruited all patients presenting with acute stroke at the National Hospital Abuja between January 2010 and June 2012. We assessed clinical and laboratory variables, as well as brain computerized tomography, magnetic resonance imaging, and carotid Doppler ultrasound scans. We also assessed case fatality and functional outcome at 30 days after stroke. Results: Of 272 patients studied, 168 (61.8% were males. Age at presentation (mean ± standard deviation was 56.4 ± 12.7 years in males and 52.9 ± 14.8 years in females ( P = 0.039. Neuroimaging was obtained in 96.7% patients, revealing cerebral infarction (61.8%, intracerebral hemorrhage (ICH (34.8%, and subarachnoid hemorrhage (SAH (3.4%. Carotid plaques or stenosis ≥50% were detected in 53.2% patients with cerebral infarction. Stroke risk factors included hypertension (82.7%, obesity (32.6%, diabetes (23.5%, hyperlipidemia (18.4%, atrial fibrillation (9.2%, and cigarette smoking (7.7%. At 30 days after stroke, case-fatality rate was 18.8%, whereas modified Rankin Scale (mRS scores for cerebral infarction, ICH, and SAH were 3.71, 4.21, and 4.56, respectively. Atrial fibrillation, a previous stroke, and age older than 50 years were all associated with worse mRS scores at 30 days. Conclusion: Although hypertension, obesity, diabetes mellitus, and atrial fibrillation were important stroke risk factors, in many patients, these were detected only after a stroke. While the commonest stroke subtype was cerebral infarction, observed in almost two-third of patients, SAH was associated with the highest case-fatality rate at

  5. Prenatal Transmission of Syphilis and Human Immunodeficiency Virus in Brazil: Achieving Regional Targets for Elimination.

    Science.gov (United States)

    Cerda, Rodrigo; Perez, Freddy; Domingues, Rosa Maria S M; Luz, Paula M; Grinsztejn, Beatriz; Veloso, Valdilea G; Caffe, Sonja; Francke, Jordan A; Freedberg, Kenneth A; Ciaranello, Andrea L

    2015-04-01

    Background.  The Pan-American Health Organization has called for reducing (1) human immunodeficiency virus (HIV) mother-to-child transmission (MTCT) to ≤0.30 infections/1000 live births (LB), (2) HIV MTCT risk to ≤2.0%, and (3) congenital syphilis (CS) incidence to ≤0.50/1000 LB in the Americas by 2015. Methods.  Using published Brazilian data in a mathematical model, we simulated a cohort of pregnant women from antenatal care (ANC) through birth. We investigated 2 scenarios: "current access" (89.1% receive one ANC syphilis test and 41.1% receive 2; 81.7% receive one ANC HIV test and 18.9% receive birth testing; if diagnosed, 81.0% are treated for syphilis and 87.5% are treated for HIV) and "ideal access" (95% of women undergo 2 HIV and syphilis screenings; 95% receive appropriate treatment). We conducted univariate and multivariate sensitivity analyses on key inputs. Results.  With current access, we projected 2.95 CS cases/1000 LB, 0.29 HIV infections/1000 LB, 7.1% HIV MTCT risk, and 11.11 intrauterine fetal demises (IUFD)/1000 pregnancies, with significant regional variation. With ideal access, we projected improved outcomes: 1.00 CS cases/1000 LB, 0.10 HIV infections/1000 LB, HIV MTCT risk of 2.4%, and 10.65 IUFD/1000 pregnancies. Increased testing drove the greatest improvements. Even with ideal access, only HIV infections/1000 LB met elimination goals. Achieving all targets required testing and treatment >95% and reductions in prevalence and incidence of HIV and syphilis. Conclusions.  Increasing access to care and HIV and syphilis antenatal testing will substantially reduce HIV and syphilis MTCT in Brazil. In addition, regionally tailored interventions reducing syphilis incidence and prevalence and supporting HIV treatment adherence are necessary to completely meet elimination goals. PMID:26180825

  6. The Impact of Home Environment Factors on Academic Performance of Senior Secondary School Students in Garki Area District, Abuja - Nigeria

    Directory of Open Access Journals (Sweden)

    L. T. Dzever

    2015-12-01

    Full Text Available The study examined the impact of home environment factors on the academic performance of public secondary school students in Garki Area District, Abuja, Nigeria. The stratified sampling technique was used to select 300 students from six public schools, while the simple random sampling technique was used to administer the questionnaire. The study utilized a descriptive survey research design for the study. Also, data on student’s academic performance was obtained from student’s scores in four selected school subjects. Data obtained was analyzed using descriptive and inferential statistical techniques; Pearson Product Moment Correlation and Multiple regression analysis (ANOVA. The results result revealed a positive and significant relationship between permissive patenting style with academic performance (p0.05. Also, the result from the study identified income, educational background and occupational level as well as permissive parenting style as the main predictive variables influencing students’ academic performance.

  7. Modelling Recycling Targets:Achieving a 50% Recycling Rate for Household Waste in Denmark

    OpenAIRE

    Hill, Amanda Louise; Leinikka Dall, Ole; Andersen, Frits M.

    2014-01-01

    Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, whereEU waste directives and national waste strategies are placing emphasis on resource efficiency andrecycling targets. The most recent Danish resource strategy calculates a national recycling rate of22% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This studyintegrates the recycling target into the FRIDA model to project how much waste and from whichstreams should b...

  8. Engineering fusogenic molecules to achieve targeted transduction of enveloped lentiviral vectors

    Directory of Open Access Journals (Sweden)

    Wang Pin

    2009-06-01

    Full Text Available Abstract Background Lentiviral vectors with broad tropism are one of the most promising gene delivery systems capable of efficiently delivering genes of interest into both dividing and non-dividing cells while maintaining long-term transgene expression. However, there are needs for developing lentiviral vectors with the capability to deliver genes to specific cell types, thus reducing the "off-target" effect of gene therapy. In the present study, we investigated the possibility of engineering the fusion-active domain of a fusogenic molecule (FM with the aim to improve targeted transduction of lentiviral vectors co-displaying an anti-CD20 antibody (αCD20 and a FM. Results Specific mutations were introduced into the fusion domain of a binding-deficient Sindbis virus glycoprotein to generate several mutant FMs. Lentiviral vectors incorporated with αCD20 and one of the engineered FMs were successfully produced and demonstrated to be able to preferentially deliver genes to CD-20-expressing cells. Lentiviral vectors bearing engineered FMs exhibited 8 to 17-fold enhanced transduction towards target cells as compared to the parental FM. Different levels of enhancement were observed for the different engineered FMs. A pH-dependent study of vector transduction showed that the broader pH range of the engineered FM is a possible mechanism for the resulted increase in transduction efficiency. Conclusion The fusion domain of Sindbis virus glycoprotein is amenable for engineering and the engineered proteins provide elevated capacity to mediate lentiviral vectors for targeted transduction. Our data suggests that application of such an engineering strategy can optimize the two-molecular targeting method of lentiviral vectors for gene delivery to predetermined cells.

  9. The Knowledge Base for Achieving the Sustainable Development Goal Targets on Water Supply, Sanitation and Hygiene

    OpenAIRE

    Hutton, Guy; Chase, Claire

    2016-01-01

    Safe drinking water, sanitation, and hygiene (WASH) are fundamental to an improved standard of living. Globally, 91% of households used improved drinking water sources in 2015, while for improved sanitation it is 68%. Wealth disparities are stark, with rural populations, slum dwellers and marginalized groups lagging significantly behind. Service coverage is significantly lower when considering the new water and sanitation targets under the sustainable development goals (SDGs) which aspire to ...

  10. Nutritionists in industry can play a key role in helping to achieve Health of the Nation targets for nutrition.

    Science.gov (United States)

    Kirk, T R; de Looy, A; Fletcher, R; Ruxton, C H

    2007-06-01

    Nutritionists working in food manufacturing and retailing are potentially in a more powerful position than any other professional group to contribute towards achieving the national targets for nutrition and the reduction of nutrition-related diseases, set out in The Health of the Nation (DoH, 1992) and in Scotland's Health, A Challenge to Us All (Scottish Office, 1993). The present paper sets out the details of this argument. First, a review is given of the functions and types of activities carried out by nutritionists in industry. Then a number of key practical ways in which nutritionists, through their activities and functions, can help towards achieving national targets for nutrition and nutrition-related diseases are described. Finally, suggestions are made about the knowledge, skills, and personal attributes needed by nutritionists who intend making successful careers in industry and who wish, at the same time, to contribute towards improving the health of the nation. PMID:17539871

  11. A STUDY OF IGNITION, PROPAGATION OF BURN AND ACHIEVEMENT OF HIGH-GAIN IN INERTIAL FUSION TARGETS

    OpenAIRE

    Tahir, N.; Long, K.

    1988-01-01

    This paper discusses different ignition models including the volume ignition and a central ignition model. A comparison is made between these two models which shows that the central ignition model is superior to the volume ignition model. It is also demonstrated with the help of computer simulations how one may achieve a central ignition configuration in a reactor-size inertial confinement fusion target. The problem of propagation of burn from the central hot zone into the surrounding cold fu...

  12. Mobile Health Insurance System and Associated Costs: A Cross-Sectional Survey of Primary Health Centers in Abuja, Nigeria

    Science.gov (United States)

    Garg, Lalit; Eze, Godson

    2016-01-01

    Background Nigeria contributes only 2% to the world’s population, accounts for 10% of the global maternal death burden. Health care at primary health centers, the lowest level of public health care, is far below optimal in quality and grossly inadequate in coverage. Private primary health facilities attempt to fill this gap but at additional costs to the client. More than 65% Nigerians still pay out of pocket for health services. Meanwhile, the use of mobile phones and related services has risen geometrically in recent years in Nigeria, and their adoption into health care is an enterprise worth exploring. Objective The purpose of this study was to document costs associated with a mobile technology–supported, community-based health insurance scheme. Methods This analytic cross-sectional survey used a hybrid of mixed methods stakeholder interviews coupled with prototype throw-away software development to gather data from 50 public primary health facilities and 50 private primary care centers in Abuja, Nigeria. Data gathered documents costs relevant for a reliable and sustainable mobile-supported health insurance system. Clients and health workers were interviewed using structured questionnaires on services provided and cost of those services. Trained interviewers conducted the structured interviews, and 1 client and 1 health worker were interviewed per health facility. Clinic expenditure was analyzed to include personnel, fixed equipment, medical consumables, and operation costs. Key informant interviews included a midmanagement staff of a health-management organization, an officer-level staff member of a mobile network operator, and a mobile money agent. Results All the 200 respondents indicated willingness to use the proposed system. Differences in the cost of services between public and private facilities were analyzed at 95% confidence level (Pcost of services at private health care facilities is significantly higher than at public primary health care

  13. Dobutamine stress echo is superior to exercise stress testing in achieving target heart rate among patients on beta blockers.

    Science.gov (United States)

    Sabbath, Adam; Pack, Michael; Markiewicz, Richard; John, Jooby; Gaballa, Mohamed; Goldman, Steven; Thai, Hoang

    2005-01-01

    Published guidelines recommend continuing beta-adrenergic receptor blockade in patients undergoing stress testing. We evaluated the role of pharmacological versus exercise stress testing in achieving target heart rate (THR) among patients on beta-adrenergic blockade. We compared data from 140 patients who underwent dobutamine stress echo (DSE) and 143 patients who underwent exercise treadmill testing (ETT). In both groups, beta-adrenergic blocker was continued at the time of stress testing. Overall, patients undergoing DSE achieved THR more frequently than ETT. With beta-adrenergic blockade, DSE patients met THR more frequently than ETT patients (p < 0.001). Without beta-adrenergic blockade, there was no difference between either modality in achieving THR. In both DSE and ETT patients, absence of beta-adrenergic blockade increased the odds of achieving THR [odds ratio (OR): 2.46, p = 0.042 and OR: 7.44, p < 0.001, respectively]. Atropine use with DSE increased the odds of achieving THR (OR: 3.76, p = 0.006). In conclusion, pharmacological stress testing appears to be superior to exercise stress testing in achieving THR among patients on beta-adrenergic blockade.

  14. Trade-offs of different land and bioenergy policies on the path to achieving climate targets

    Energy Technology Data Exchange (ETDEWEB)

    Calvin, Katherine V. [Joint Global Change Research Inst., College Park, MD (United States); Wise, Marshall A. [Joint Global Change Research Inst., College Park, MD (United States); Kyle, G. Page [Joint Global Change Research Inst., College Park, MD (United States); Patel, Pralit L. [Joint Global Change Research Inst., College Park, MD (United States); Clarke, Leon E. [Joint Global Change Research Inst., College Park, MD (United States); Edmonds, James A. [Joint Global Change Research Inst., College Park, MD (United States)

    2013-10-16

    Many papers have shown that bioenergy and land-use are potentially important elements in a strategy to limit anthropogenic climate change. But, significant expansion of bioenergy production can have a large terrestrial footprint. In this paper, we test the implications for land use, the global energy system, carbon cycle, and carbon prices of meeting a specific climate target, using a single fossil fuel and industrial sector policy instrument—the carbon tax, but with five alternative bioenergy and land-use policy architectures. We find that the policies we examined have differing effects on the different segments of the economy. Comprehensive land policies can reduce land-use change emissions, increasing allowable emissions in the energy system, but have implications for the cost of food. Bioenergy taxes and constraints, on the other hand, have little effect on food prices, but can result in increased carbon and energy prices.

  15. Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.

    Science.gov (United States)

    Yamniuk, Aaron P; Suri, Anish; Krystek, Stanley R; Tamura, James; Ramamurthy, Vidhyashankar; Kuhn, Robert; Carroll, Karen; Fleener, Catherine; Ryseck, Rolf; Cheng, Lin; An, Yongmi; Drew, Philip; Grant, Steven; Suchard, Suzanne J; Nadler, Steven G; Bryson, James W; Sheriff, Steven

    2016-07-17

    Current clinical anti-CD40 biologic agents include both antagonist molecules for the treatment of autoimmune diseases and agonist molecules for immuno-oncology, yet the relationship between CD40 epitope and these opposing biological outcomes is not well defined. This report describes the identification of potent antagonist domain antibodies (dAbs) that bind to a novel human CD40-specific epitope that is divergent in the CD40 of nonhuman primates. A similarly selected anti-cynomolgus CD40 dAb recognizing the homologous epitope is also a potent antagonist. Mutagenesis, biochemical, and X-ray crystallography studies demonstrate that the epitope is distinct from that of CD40 agonists. Both the human-specific and cynomolgus-specific molecules remain pure antagonists even when formatted as bivalent Fc-fusion proteins, making this an attractive therapeutic format for targeting hCD40 in autoimmune indications. PMID:27216500

  16. The Knowledge Base for Achieving the Sustainable Development Goal Targets on Water Supply, Sanitation and Hygiene.

    Science.gov (United States)

    Hutton, Guy; Chase, Claire

    2016-01-01

    Safe drinking water, sanitation, and hygiene (WASH) are fundamental to an improved standard of living. Globally, 91% of households used improved drinking water sources in 2015, while for improved sanitation it is 68%. Wealth disparities are stark, with rural populations, slum dwellers and marginalized groups lagging significantly behind. Service coverage is significantly lower when considering the new water and sanitation targets under the sustainable development goals (SDGs) which aspire to a higher standard of 'safely managed' water and sanitation. Lack of access to WASH can have an economic impact as much as 7% of Gross Domestic Product, not including the social and environmental consequences. Research points to significant health and socio-economic consequences of poor nutritional status, child growth and school performance caused by inadequate WASH. Groundwater over-extraction and pollution of surface water bodies have serious impacts on water resource availability and biodiversity, while climate change exacerbates the health risks of water insecurity. A significant literature documents the beneficial impacts of WASH interventions, and a growing number of impact evaluation studies assess how interventions are optimally financed, implemented and sustained. Many innovations in behavior change and service delivery offer potential for scaling up services to meet the SDGs. PMID:27240389

  17. The Knowledge Base for Achieving the Sustainable Development Goal Targets on Water Supply, Sanitation and Hygiene.

    Science.gov (United States)

    Hutton, Guy; Chase, Claire

    2016-05-27

    Safe drinking water, sanitation, and hygiene (WASH) are fundamental to an improved standard of living. Globally, 91% of households used improved drinking water sources in 2015, while for improved sanitation it is 68%. Wealth disparities are stark, with rural populations, slum dwellers and marginalized groups lagging significantly behind. Service coverage is significantly lower when considering the new water and sanitation targets under the sustainable development goals (SDGs) which aspire to a higher standard of 'safely managed' water and sanitation. Lack of access to WASH can have an economic impact as much as 7% of Gross Domestic Product, not including the social and environmental consequences. Research points to significant health and socio-economic consequences of poor nutritional status, child growth and school performance caused by inadequate WASH. Groundwater over-extraction and pollution of surface water bodies have serious impacts on water resource availability and biodiversity, while climate change exacerbates the health risks of water insecurity. A significant literature documents the beneficial impacts of WASH interventions, and a growing number of impact evaluation studies assess how interventions are optimally financed, implemented and sustained. Many innovations in behavior change and service delivery offer potential for scaling up services to meet the SDGs.

  18. The Knowledge Base for Achieving the Sustainable Development Goal Targets on Water Supply, Sanitation and Hygiene

    Science.gov (United States)

    Hutton, Guy; Chase, Claire

    2016-01-01

    Safe drinking water, sanitation, and hygiene (WASH) are fundamental to an improved standard of living. Globally, 91% of households used improved drinking water sources in 2015, while for improved sanitation it is 68%. Wealth disparities are stark, with rural populations, slum dwellers and marginalized groups lagging significantly behind. Service coverage is significantly lower when considering the new water and sanitation targets under the sustainable development goals (SDGs) which aspire to a higher standard of ‘safely managed’ water and sanitation. Lack of access to WASH can have an economic impact as much as 7% of Gross Domestic Product, not including the social and environmental consequences. Research points to significant health and socio-economic consequences of poor nutritional status, child growth and school performance caused by inadequate WASH. Groundwater over-extraction and pollution of surface water bodies have serious impacts on water resource availability and biodiversity, while climate change exacerbates the health risks of water insecurity. A significant literature documents the beneficial impacts of WASH interventions, and a growing number of impact evaluation studies assess how interventions are optimally financed, implemented and sustained. Many innovations in behavior change and service delivery offer potential for scaling up services to meet the SDGs. PMID:27240389

  19. The Knowledge Base for Achieving the Sustainable Development Goal Targets on Water Supply, Sanitation and Hygiene

    Directory of Open Access Journals (Sweden)

    Guy Hutton

    2016-05-01

    Full Text Available Safe drinking water, sanitation, and hygiene (WASH are fundamental to an improved standard of living. Globally, 91% of households used improved drinking water sources in 2015, while for improved sanitation it is 68%. Wealth disparities are stark, with rural populations, slum dwellers and marginalized groups lagging significantly behind. Service coverage is significantly lower when considering the new water and sanitation targets under the sustainable development goals (SDGs which aspire to a higher standard of ‘safely managed’ water and sanitation. Lack of access to WASH can have an economic impact as much as 7% of Gross Domestic Product, not including the social and environmental consequences. Research points to significant health and socio-economic consequences of poor nutritional status, child growth and school performance caused by inadequate WASH. Groundwater over-extraction and pollution of surface water bodies have serious impacts on water resource availability and biodiversity, while climate change exacerbates the health risks of water insecurity. A significant literature documents the beneficial impacts of WASH interventions, and a growing number of impact evaluation studies assess how interventions are optimally financed, implemented and sustained. Many innovations in behavior change and service delivery offer potential for scaling up services to meet the SDGs.

  20. Malaria in pregnancy; facts from the parasitology laboratory: a ten-year study in Abuja, North Central Nigeria

    Directory of Open Access Journals (Sweden)

    Ibecheozor, N.K.O

    2014-09-01

    Full Text Available Malaria, which is transmitted by female Anopheles mosquitoes, is the major cause of mortality among the pregnant women in the sub-Saharan Africa. A ten year study of malaria in pregnancy was carried out in Abuja, North Central Nigeria. Thick and thin blood films were stained with the Giemsa methodology. Of the 16760 pregnant women blood samples, 4571 (27.3% were positive for malaria parasites caused by Plasmodium falciparum. Of the 4571 positive cases, 75 (1.7% had parasite density of >5000 parasites/µl of blood; 148 (3.2% had between 500-5000 parasites/µl of blood; 520 (11.4% had between 50 - 500 parasites/µl of blood; while 3828 (83.7% had between 5-50 parasites/µl of blood. With the current estimate of over 4500 deaths of pregnant women in Nigeria due to malaria annually, we must make deliberate efforts to stop these unacceptable and painful losses. The continued use of malaria rapid diagnostic tests (M-RDTs methodologies should be discontinued because of its negative implications. Therefore, the microscopic laboratory diagnostic component should be included in ANC at all level of health care facility.

  1. MODIFIED RELEASE FORMULATIONS TO ACHIEVE THE QUALITY TARGET PRODUCT PROFILE (QTPP

    Directory of Open Access Journals (Sweden)

    Mithilesh Kumar Jha

    2012-08-01

    Full Text Available Modified Release (MR Formulations have a modification in the release mechanism. Modified release dosage forms are developed by altering drug absorption or the site of drug release in order to achieve predetermined clinical objectives. Modified drug release from dosage forms is complemented by the allied processes of drug design, of dosage administration, and of membrane transport and absorption of drug to the biological site of action. Modified-release drugs have complex formulations that can offer an advantage over standard medication for some patients. Modified-release preparations should only be used where there is a clear clinical advantage over conventional-release preparations. In general, Modified-release preparations should be reserved for specific patients where there is a problem with compliance, effectiveness or side-effects which these preparations could help overcome. Modified–release technologies have become indispensable to resolving critical technical, therapeutic, and marketing challenges, such as improving patience compliance, less dosage timings, better safety, better indications, delivering poorly soluble and poorly absorbable API’s, product differentiation, patent protection, product life-cycle extension, and better margins. Modified-release formulation design can be conducted for oral and non-oral administration routes. Possible therapeutic benefits of an MR product include improved efficacy and reduced adverse events, increased convenience and patient compliance, optimized performance, a greater selectivity of activity, or new indications.

  2. Achievement of Target Blood Pressure Levels among Japanese Workers with Hypertension and Healthy Lifestyle Characteristics Associated with Therapeutic Failure.

    Directory of Open Access Journals (Sweden)

    Nagako Kudo

    Full Text Available Few studies have examined Japanese with regard to the achievement rates for target blood pressure levels, or the relationship between these rates and healthy lifestyle characteristics in patients with hypertension as defined by the newly established hypertension management guidelines (JSH2014. The aim of this study was to elucidate achievement rates and examine healthy lifestyle characteristics associated with achievement status among Japanese.This cross-sectional study, conducted in January-December 2012, examined blood pressure control and healthy lifestyle characteristics in 8,001 Japanese workers with hypertension (mean age, 57.0 years; 78.8% were men who participated in a workplace health checkup. Data were collected from workplace medical checkup records and participants' self-administered questionnaires. We divided into 5 groups [G1; young, middle-aged, and early-phase elderly patients (65-74 years old without diabetes mellitus or chronic kidney disease (CKD (<140/90 mmHg, G2; late-phase elderly patients (≥75 years old without diabetes mellitus or CKD (<150/90 mmHg, G3; diabetic patients (<130/80 mmHg, G4; patients with CKD (<130/80 mmHg, and G5; patients with cerebrovascular and/or coronary artery diseases (<140/90 mmHg] according to JSH2014. And then, achievement rates were calculated in each group. Multivariate analysis identified healthy lifestyle characteristics associated with "therapeutic failure" of target blood pressure.Target blood pressures were achieved by 60.2% of young, middle-aged, and early-phase elderly patients (G1, 71.4% of late-phase elderly patients (G2, 30.5% of diabetic patients (G3, 33.4% of those with chronic kidney disease (G4, and 66.0% of those with cerebrovascular and/or coronary artery diseases (G5. A body mass index of 18.5-24.9 and non-daily alcohol consumption were protective factors, and adequate sleep was found to contribute to therapeutic success.We found low achievement rates for treatment goals

  3. Is the Target of 1 Day of Stay per 1% Total Body Surface Area Burned Achieved in Chemical Burns?

    Science.gov (United States)

    Tan, Teresa; Wong, David S Y

    2016-02-01

    The length of hospital stay (LOS) is a standard parameter used to reflect quality and evaluate outcomes in acute burn care. This study aims to assess whether the target of 1 day of stay per 1% total body surface area (TBSA) burned was achieved in acute chemical burns management and factors affecting the LOS. A retrospective analysis of the records of patients who suffered from chemical burn injuries admitted to a university burn center over a continuous 14-year period was performed.A total of 118 patients were admitted over the period for chemical burns. Only 14% of cases achieved the target stated. Factors associated with lengthening of the hospital stay included TBSA, ocular involvement, the cause of injury, and the need for surgery during the same admission.The LOS in chemical burns frequently exceeds 1 day of stay per 1% TBSA burned. Many factors can contribute to a patient's LOS and are worth exploring in order to see if the impact of these factors could be minimized. Early surgical intervention should help to reduce the LOS if reliable methods of burn wound depth assessment are available.

  4. A Pharmacist-Staffed, Virtual Gout Management Clinic for Achieving Target Serum Uric Acid Levels: A Randomized Clinical Trial

    Science.gov (United States)

    Goldfien, Robert; Pressman, Alice; Jacobson, Alice; Ng, Michele; Avins, Andrew

    2016-01-01

    Context: Relatively few patients with gout receive appropriate treatment. Objective: To determine whether a pharmacist-staffed gout management program is more effective than usual care in achieving target serum uric acid (sUA) levels in gout patients. Design: A parallel-group, randomized controlled trial of a pharmacist-staffed, telephone-based program for managing hyperuricemia vs usual care. Trial duration was 26 weeks. Main Outcome Measures: Primary outcome measure was achieving sUA levels at or below 6 mg/dL at the 26-week visit. Secondary outcome was mean change in sUA levels in the control and intervention groups. Participants were adults with recurrent gout and sUA levels above 6.0 mg/dL. Participants were randomly assigned to management by a clinical pharmacist following protocol or to monitoring of sUA levels but management of their gout by their usual treating physician. Results: Of 102 patients who met eligibility criteria, 77 subjects obtained a baseline sUA measurement and were entered into the trial. Among 37 participants in the intervention group, 13 (35%) had sUA levels at or below 6.0 mg/dL at 26 weeks, compared with 5 (13%) of 40 participants in the control group (risk ratio = 2.8, 95% confidence interval [CI] = 1.1 to 7.1, p = 0.03). The mean change in sUA levels among controls was +0.1 mg/dL compared with −1.5 mg/dL in the intervention group (sUA difference = −1.6, 95% CI = −0.9 to −2.4, p pharmacist-staffed program was more effective than usual care for achieving target sUA levels. These results suggest a structured program could greatly improve gout management. PMID:27352414

  5. Achieving stringent climate targets

    OpenAIRE

    Pietzcker, Robert Carl

    2015-01-01

    Der anthropogene Klimawandel gefährdet das Wohlergehen der Menschheit. Aus diesem Grund haben Politiker wiederholt das Ziel formuliert, die Erhöhung der mittleren globalen Temperatur auf weniger als 2◦C über dem vorindustriellen Wert zu begrenzen. Dazu müssen die globalen Treibhausgasemissionen nahezu vollständig vermieden werden. Da das heutige globale System zur Energienutzung auf fossilen Rohstoffen beruht, erfordert die Reduktion von Treibhausgasemissionen eine fundamentale Umgestaltung u...

  6. Evaluation of soil corrosivity and aquifer protective capacity using geoelectrical investigation in Bwari basement complex area, Abuja

    Indian Academy of Sciences (India)

    A E Adeniji; O V Omonona; D N Obiora; J U Chukudebelu

    2014-04-01

    Bwari is one of the six municipal area councils of the Federal Capital Territory (FCT), Abuja with its attendant growing population and infrastructural developments. Groundwater is the main source of water supply in the area, and urbanization and industrialization are the predominant contributors of contaminants to the hydrological systems. In order to guarantee a continuous supply of potable water, there is a need to investigate the vulnerability of the aquifers to contaminants emanating from domestic and industrial wastes. A total of 20 vertical electrical soundings using Schlumberger electrode array with a maximum half current electrodes separation of 300 m was employed. The results show that the area is characterized by 3–6 geoelectric subsurface layers. The measured overburden thickness ranges from 1.0 to 24.3 m, with a mean value of 7.4 m. The resistivity and longitudinal conductance of the overburden units range from 18 to 11,908 m and 0.047 to 0.875 mhos, respectively. Areas considered as high corrosivity are the central parts with > 180 m. The characteristic longitudinal unit conductance was used to classify the area into zones of good (0.7–4.49 mhos), moderate (0.2–0.69 mhos), weak (0.1–0.19 mhos), and poor (> 0.1) aquifer protective capacity. Zones characterized by materials of moderate to good protective capacity serve as sealing potential for the underlying hydrogeological system in the area. This study is aimed at delineating zones that are very prone to groundwater contamination from surface contaminants and subsurface soils that are corrosive to utility pipes buried underground. Hence the findings of this work will constitute part of the tools for groundwater development and management and structural/infrastructural development planning of the area.

  7. Efficacy of a liquid low-energy formula diet in achieving preoperative target weight loss before bariatric surgery

    DEFF Research Database (Denmark)

    Nielsen, Lone Vestergaard; Nielsen, Mette Søndergaard; Schmidt, Julie Berg;

    2016-01-01

    A preoperative weight loss of 8 % is a prerequisite to undergo bariatric surgery (BS) in Denmark. The aim of the present study was to evaluate the efficacy of a 7- or an 11-week low-energy diet (LCD) for achieving preoperative target weight before BS. A total of thirty obese patients (BMI 46·0 (sd...... 4·4) kg/m2) followed an LCD (Cambridge Weight Plan®, 4184 kJ/d (1000 kcal/d)) for 7 or 11 weeks as preparation for BS. Anthropometric measurements including body composition (dual-energy X-ray absorptiometry), blood parameters and blood pressure were assessed at weeks 0, 7 and 11. At week 7...... in TAG (P LCD within 7 weeks as part of preparation for BS...

  8. Korea's emission trading scheme and policy design issues to achieve market-efficiency and abatement targets

    International Nuclear Information System (INIS)

    In 2008, the government of Republic of Korea (Korea) announced the national abatement target aiming at 30% reductions from the Business-as-Usual projections by 2020. Accordingly, the Emission Trading Scheme (ETS) will be implemented from 2015 onwards. As ETS performance substantially depends on the structural design, it is critically important to examine the details of Korean ETS for the achievement of cost effectiveness and concurrent development of an active emission trading market. This paper addresses several policy design issues for this purpose. After providing an overview on the current framework of Korean ETS, we propose ways to achieve flexibility, consistency and market efficiency of the program in consideration of the preexisting policies. Issues in policy design are discussed by focusing on allowance allocation, market stabilization measures and price mechanism in the emission and energy markets in Korea. This paper will serve as a practical guideline for establishing sustainable and market-efficient Korean ETS that can be compatible with the international standards as in the EU ETS. - Highlights: • Emission Trading Scheme (ETS) will be implemented from 2015 in Korea to reduce CO2. • ETS performance substantially depends on structural design. • We provide policy overview on the current framework of Korean ETS. • Several policy design issues are discussed for developing policy consistency. • We focus on allowance allocation, allowance reserve and market stabilization measures

  9. An intensive nurse-led, multi-interventional clinic is more successful in achieving vascular risk reduction targets than standard diabetes care.

    LENUS (Irish Health Repository)

    MacMahon Tone, J

    2009-06-01

    The aim of this research was to determine whether an intensive, nurse-led clinic could achieve recommended vascular risk reduction targets in patients with type 2 diabetes as compared to standard diabetes management.

  10. Can we bet on negative emissions to achieve the 2°C target even under strong carbon cycle feedbacks?

    Science.gov (United States)

    Tanaka, K.; Yamagata, Y.; Yokohata, T.; Emori, S.; Hanaoka, T.

    2015-12-01

    tentative results point to a key policy message: do not rely on negative emissions to achieve the 2°C target. It would make more sense to gear climate mitigation actions toward the stabilization target without betting on negative emissions because negative emissions might create large overshoot in case of strong feedbacks.

  11. Gracilaria lemaneiformis polysaccharide as integrin-targeting surface decorator of selenium nanoparticles to achieve enhanced anticancer efficacy.

    Science.gov (United States)

    Jiang, Wenting; Fu, Yuanting; Yang, Fang; Yang, Yufeng; Liu, Ting; Zheng, Wenjie; Zeng, Lilan; Chen, Tianfeng

    2014-08-27

    The poor permeability of glioma parenchyma represents a major limit for antiglioblastoma drug delivery. Gracilaria lemaneiformis polysaccharide (GLP), which has a high binding affinity to αvβ3 integrin overexpressed in glioma cells, was employed in the present study to functionalize selenium nanoparticles (SeNPs) to achieve antiglioblastoma efficacy. GLP-SeNPs showed satisfactory size distribution, high stability, and selectivity between cancer and normal cells. In U87 glioma cell membrane, which has a high integrin expression level, GLP-SeNPs exhibited significantly higher cellular uptake than unmodified SeNPs. As expected, U87 cells exhibited a greater uptake of GLP-SeNPs than C6 cells with low integrin expression level. Furthermore, the internalization of GLP-SeNPs was inhibited by cyclo-(Arg-Gly-Asp-Phe-Lys) peptides, suggesting that cellular uptake into U87 cells and C6 cells occurred via αvβ3 integrin-mediated endocytosis. For U87 cells, the cytotoxicity of SeNPs decorated by GLP was enhanced significantly because of the induction of various apoptosis signaling pathways. Internalized GLP-SeNPs triggered intracellular reactive oxygen species downregulation. Therefore, p53, MAPKs, and AKT pathways were activated to advance cell apoptosis. These findings suggest that surface decoration of nanomaterials with GLP could be an efficient strategy for design and preparation of glioblastoma targeting nanodrugs.

  12. Vitamin K antagonist use: evidence of the difficulty of achieving and maintaining target INR range and subsequent consequences.

    Science.gov (United States)

    Schein, Jeff R; White, C Michael; Nelson, Winnie W; Kluger, Jeffrey; Mearns, Elizabeth S; Coleman, Craig I

    2016-01-01

    Vitamin K antagonists (VKAs) are effective oral anticoagulants that are titrated to a narrow therapeutic international normalized ratio (INR) range. We reviewed published literature assessing the impact of INR stability - getting into and staying in target INR range - on outcomes including thrombotic events, major bleeding, and treatment costs, as well as key factors that impact INR stability. A time in therapeutic range (TTR) of ≥65 % is commonly accepted as the definition of INR stability. In the real-world setting, this is seldom achieved with standard-of-care management, thus increasing the patients' risks of thrombotic or major bleeding events. There are many factors associated with poor INR control. Being treated in community settings, newly initiated on a VKA, younger in age, or nonadherent to therapy, as well as having polymorphisms of CYP2C9 or VKORC1, or multiple physical or mental co-morbid disease states have been associated with lower TTR. Clinical prediction tools are available, though they can only explain <10 % of the variance behind poor INR control. Clinicians caring for patients who require anticoagulation are encouraged to intensify diligence in INR management when using VKAs and to consider appropriate use of newer anticoagulants as a therapeutic option. PMID:27303213

  13. Gracilaria lemaneiformis polysaccharide as integrin-targeting surface decorator of selenium nanoparticles to achieve enhanced anticancer efficacy.

    Science.gov (United States)

    Jiang, Wenting; Fu, Yuanting; Yang, Fang; Yang, Yufeng; Liu, Ting; Zheng, Wenjie; Zeng, Lilan; Chen, Tianfeng

    2014-08-27

    The poor permeability of glioma parenchyma represents a major limit for antiglioblastoma drug delivery. Gracilaria lemaneiformis polysaccharide (GLP), which has a high binding affinity to αvβ3 integrin overexpressed in glioma cells, was employed in the present study to functionalize selenium nanoparticles (SeNPs) to achieve antiglioblastoma efficacy. GLP-SeNPs showed satisfactory size distribution, high stability, and selectivity between cancer and normal cells. In U87 glioma cell membrane, which has a high integrin expression level, GLP-SeNPs exhibited significantly higher cellular uptake than unmodified SeNPs. As expected, U87 cells exhibited a greater uptake of GLP-SeNPs than C6 cells with low integrin expression level. Furthermore, the internalization of GLP-SeNPs was inhibited by cyclo-(Arg-Gly-Asp-Phe-Lys) peptides, suggesting that cellular uptake into U87 cells and C6 cells occurred via αvβ3 integrin-mediated endocytosis. For U87 cells, the cytotoxicity of SeNPs decorated by GLP was enhanced significantly because of the induction of various apoptosis signaling pathways. Internalized GLP-SeNPs triggered intracellular reactive oxygen species downregulation. Therefore, p53, MAPKs, and AKT pathways were activated to advance cell apoptosis. These findings suggest that surface decoration of nanomaterials with GLP could be an efficient strategy for design and preparation of glioblastoma targeting nanodrugs. PMID:25073123

  14. Analysis of Settlement Expansion and Urban Growth Modelling Using Geoinformation for Assessing Potential Impacts of Urbanization on Climate in Abuja City, Nigeria

    Directory of Open Access Journals (Sweden)

    Mahmoud Ibrahim Mahmoud

    2016-03-01

    Full Text Available This study analyzed the spatiotemporal pattern of settlement expansion in Abuja, Nigeria, one of West Africa’s fastest developing cities, using geoinformation and ancillary datasets. Three epochs of Land-use Land-cover (LULC maps for 1986, 2001 and 2014 were derived from Landsat images using support vector machines (SVM. Accuracy assessment (AA of the LULC maps based on the pixel count resulted in overall accuracy of 82%, 92% and 92%, while the AA derived from the error adjusted area (EAA method stood at 69%, 91% and 91% for 1986, 2001 and 2014, respectively. Two major techniques for detecting changes in the LULC epochs involved the use of binary maps as well as a post-classification comparison approach. Quantitative spatiotemporal analysis was conducted to detect LULC changes with specific focus on the settlement development pattern of Abuja, the federal capital city (FCC of Nigeria. Logical transitions to the urban category were modelled for predicting future scenarios for the year 2050 using the embedded land change modeler (LCM in the IDRISI package. Based on the EAA, the result showed that urban areas increased by more than 11% between 1986 and 2001. In contrast, this value rose to 17% between 2001 and 2014. The LCM model projected LULC changes that showed a growing trend in settlement expansion, which might take over allotted spaces for green areas and agricultural land if stringent development policies and enforcement measures are not implemented. In conclusion, integrating geospatial technologies with ancillary datasets offered improved understanding of how urbanization processes such as increased imperviousness of such a magnitude could influence the urban microclimate through the alteration of natural land surface temperature. Urban expansion could also lead to increased surface runoff as well as changes in drainage geography leading to urban floods.

  15. Effects of Achieving Target Measures in Rheumatoid Arthritis on Functional Status, Quality of Life, and Resource Utilization: Analysis of Clinical Practice Data

    Science.gov (United States)

    Joo, Seongjung; Kawabata, Hugh; Al, Maiwenn J.; Allison, Paul D.; Rutten‐van Mölken, Maureen P. M. H.; Frits, Michelle L.; Iannaccone, Christine K.; Shadick, Nancy A.; Weinblatt, Michael E.

    2016-01-01

    Objective To evaluate associations between achieving guideline‐recommended targets of disease activity, defined by the Disease Activity Score in 28 joints using C‐reactive protein level (DAS28‐CRP) control for intraclass correlation and estimate effects of independent variables on outcomes of the modified Health Assessment Questionnaire (M‐HAQ), the EuroQol 5‐domain (EQ‐5D; a quality‐of‐life measure), hospitalization, and durable medical equipment (DME) use, we employed mixed models for continuous outcomes and generalized estimating equations for binary outcomes. Results Among 1,297 subjects, achievement (versus nonachievement) of recommended disease targets was associated with enhanced physical functioning and lower health resource utilization. After controlling for baseline covariates, achievement of disease targets (versus LDA) was associated with significantly enhanced physical functioning based on SDAI ≤3.3 (ΔM‐HAQ −0.047; P = 0.0100) and CDAI ≤2.8 (−0.073; P = 0.0003) but not DAS28‐CRP <2.6 (−0.022; P = 0.1735). Target attainment was associated with significantly improved EQ‐5D (0.022–0.096; P < 0.0030 versus LDA, MDA, or SDA). Patients achieving guideline‐recommended disease targets were 36–45% less likely to be hospitalized (P < 0.0500) and 23–45% less likely to utilize DME (P < 0.0100). Conclusion Attaining recommended target disease‐activity measures was associated with enhanced physical functioning and health‐related quality of life. Some health outcomes were similar in subjects attaining guideline targets versus LDA. Achieving LDA is a worthy clinical objective in some patients. PMID:26238974

  16. Cinacalcet and achievement of the NKF/K-DOQI recommended target values for bone and mineral metabolism in real-world clinical practice--the ECHO observational study

    DEFF Research Database (Denmark)

    Urena, P.; Jacobson, S.H.; Zitt, E.;

    2009-01-01

    % and 68%, respectively). At Month 12, 18% of patients had achieved the combined target for iPTH + Ca x P compared with 2% at baseline. Most patients (65%) received Vitamin D sterol use remained fairly stable throughout the study. There was a 13% decrease in prescribed...

  17. Framework for the analysis of the low-carbon scenario 2020 to achieve the national carbon Emissions reduction target: Focused on educational facilities

    International Nuclear Information System (INIS)

    Since the increase in greenhouse gas emissions has increased the global warming potential, an international agreement on carbon emissions reduction target (CERT) has been formulated in Kyoto Protocol (1997). This study aimed to develop a framework for the analysis of the low-carbon scenario 2020 to achieve the national CERT. To verify the feasibility of the proposed framework, educational facilities were used for a case study. This study was conducted in six steps: (i) selection of the target school; (ii) establishment of the reference model for the target school; (iii) energy consumption pattern analysis by target school; (iv) establishment of the energy retrofit model for the target school; (v) economic and environmental assessment through the life cycle cost and life cycle CO2 analysis; and (vi) establishment of the low-carbon scenario in 2020 to achieve the national CERT. This study can help facility managers or policymakers establish the optimal retrofit strategy within the limited budget from a short-term perspective and the low-carbon scenario 2020 to achieve the national CERT from the long-term perspective. The proposed framework could be also applied to any other building type or country in the global environment

  18. The Relationship between Anxiety and Attitude of Students Learning Turkish as a Foreign Language and Their Achievement on Target Language

    Science.gov (United States)

    Gocer, Ali

    2014-01-01

    The purpose of this study is to assess the anxiety connected with target language of the high school students learning Turkish as a foreign language. In this study, descriptive relational screening model was used. Two scales were used for collecting data. First scale was FLCAS-Foreign Language Classroom Anxiety Scale; it was developed by Horwitz…

  19. The Situation of Health Centre Facilities in Ngada District in order to Meet the Achievement Target to Reduce Malaria Morbidity

    Directory of Open Access Journals (Sweden)

    muhammad Hasyimi

    2014-08-01

    Full Text Available Background: Ngada district, East Nusa Tenggara province is one of the malaria endemic districts NTT is one of areas targeted elimination by 2030. The strategy Ministry of Health, for 2010-2014 states that malaria control targets to reducethe morbidity from 2 to 1 per 1000 population. The study aimed to elucidate information proceeding situation of Public health center (PHC, Puskesmas facilities for decresing the morbidity in 2014. Method: It was an observational studi with cross sectional design in 2014. Information was collected by interview and observation of documents at each PHC. Result: Results showed all PHCs already have malaria program, conduct blood examination, equipped microscopic and with have human resources, though there are weakness such as malaria program and microscopist trainings have not been done. Many factors contribute to increase malaria cases and unsuccessful malaria control, however, all PHCs have already malaria program, has conducted blood tests, it equipped with binocular microscope adequate, human resources,sanitarians and environmental health workers available in each PHC. International donor agencies issued as Global Fun. Conclusion: Annual Parasite Incidence and AMI in Ngada during the period of 2009 untill 2011, tend to decline. Malaria control programs have been done in all health eentres. Recommendation: For the malaria elimination there should be action programs, such as screening, enhanced of existing health workers and improving quality and coverage of malaria vector control.

  20. PROBIT MODEL ANALYSIS OF SMALLHOLDER’S FARMERS DECISION TO USE AGROCHEMICAL INPUTS IN GWAGWALADA AND KUJE AREA COUNCILS OF FEDERAL CAPITAL TERRITORY, ABUJA, NIGERIA

    Directory of Open Access Journals (Sweden)

    Omotayo Olugbenga Alabi

    2014-01-01

    Full Text Available This study examined Probit model analysis of smallholder’s farmers decision to use agrochemical inputs in Gwagwalada and Kuje Area Councils of Federal Capital Territory, Abuja, Nigeria. Primary data were used for this study. Data were obtained using structured questionnaire. The questionnaires were administered to sixty smallholder’s farmers sampled using a two-stage sampling technique. Data obtained were analyzed using descriptive statistics and Probit model. Eight estimators, age; farm-size; education–level; extension services; access to credit; off-farm income; experiences in farming; in the Probit model were found statistically significant. Results show that the probability of using agrochemical inputs increases with age; farm-size; family-size; education-level; extension services; experiences in farming but decreases where they have off-farm income and access to credits. Mc Fadden Pseudo-R 2 gives 0.6866 and Probit model correctly classified 93%. This study concluded that capacity of agricultural extension agents needs to be improved in the study area to educate farmers to invest in agrochemicals and improved agricultural technologies. Also, Government needs to improve on good road networks and appropriate policies to regulate standard, use, safety needs and environment of use of agrochemicals in the study area.

  1. Tectonic and radioactivity impacts of 238U on groundwater-based drinking water at Gosa and Lugbe areas of Abuja, North Central Nigeria

    International Nuclear Information System (INIS)

    Tectonic contribution of activity level of 238U in groundwater-based drinking water in Gosa and Lugbe areas of Abuja was measured using inductively coupled plasma mass spectrometry (ICP-MS). The highest activity level of 2736 µBq L-1 reported in Lugbe borehole, whereas the lowest value of 443 µBq L-1 reported at Gosa borehole. The inhabitants permanently used water from the boreholes for daily consumption. The group receives 5.55 × 10-5 mSv of the annual collective effective dose due to 238U in drinking water. The radiological risks of 238U in the water samples were found to be low, typically in magnitude of 10-7 with cancer mortality value of 1.03 × 10-7 and morbidity value of 1.57 × 10-7. The chemical toxicity risk of 238U in drinking water over a lifetime consumption has a mean value of 4.0 × 10-3 μg kg-1 day-1. It could be that the human risk due to 238U content in groundwater supplies from ingestion may likely be the chemical toxicity of 238U as a heavy metal rather than radiological risk. Significantly, Lugbe subsurface may have developed some fractions of granitic strata that contributed to the distribution of radioactive of 238U in tectonically weak zones. (author)

  2. Achieving California's 80% greenhouse gas reduction target in 2050: Technology, policy and scenario analysis using CA-TIMES energy economic systems model

    International Nuclear Information System (INIS)

    The CA-TIMES optimization model of the California Energy System (v1.5) is used to understand how California can meet the 2050 targets for greenhouse gas (GHG) emissions (80% below 1990 levels). This model represents energy supply and demand sectors in California and simulates the technology and resource requirements needed to meet projected energy service demands. The model includes assumptions on policy constraints, as well as technology and resource costs and availability. Multiple scenarios are developed to analyze the changes and investments in low-carbon electricity generation, alternative fuels and advanced vehicles in transportation, resource utilization, and efficiency improvements across many sectors. Results show that major energy transformations are needed but that achieving the 80% reduction goal for California is possible at reasonable average carbon reduction cost ($9 to $124/tonne CO2e at 4% discount rate) relative to a baseline scenario. Availability of low-carbon resources such as nuclear power, carbon capture and sequestration (CCS), biofuels, wind and solar generation, and demand reduction all serve to lower the mitigation costs, but CCS is a key technology for achieving the lowest mitigation costs. - Highlights: • We model the California Energy System to 2050 under policy and technology scenarios. • The model optimizes technology and resource investments to meet emissions targets. • Deep emissions cuts (>74%) are achieved across all reduction scenarios. • Carbon capture enables negative emission biofuels and allows more petroleum use. • Greenhouse gas mitigation cost is small compared with total economic activity

  3. Coated minispheres of salmon calcitonin target rat intestinal regions to achieve systemic bioavailability: Comparison between intestinal instillation and oral gavage.

    Science.gov (United States)

    Aguirre, Tanira A S; Aversa, Vincenzo; Rosa, Mónica; Guterres, Sílvia S; Pohlmann, Adriana R; Coulter, Ivan; Brayden, David J

    2016-09-28

    Achieving oral peptide delivery is an elusive challenge. Emulsion-based minispheres of salmon calcitonin (sCT) were synthesized using single multiple pill (SmPill®) technology incorporating the permeation enhancers (PEs): sodium taurodeoxycholate (NaTDC), sodium caprate (C10), or coco-glucoside (CG), or the pH acidifier, citric acid (CA). Minispheres were coated with an outer layer of Eudragit® L30 D-55 (designed for jejunal release) or Surelease®/Pectin (designed for colonic release). The process was mild and in vitro biological activity of sCT was retained upon release from minispheres stored up to 4months. In vitro release profiles suggested that sCT was released from minispheres by diffusion through coatings due to swelling of gelatin and the polymeric matrix upon contact with PBS at pH6.8. X-ray analysis confirmed that coated minispheres dissolved at the intended intestinal region of rats following oral gavage. Uncoated minispheres at a dose of ~2000I.U.sCT/kg were administered to rats by intra-jejunal (i.j.) or intra-colonic (i.c.) instillation and caused hypocalcaemia. Notable sCT absolute bioavailability (F) values were: 5.5% from minispheres containing NaTDC (i.j), 17.3% with CG (i.c.) and 18.2% with C10 (i.c.). Coated minispheres administered by oral gavage at threefold higher doses also induced hypocalcaemia. A highly competitive F value of 2.7% was obtained for orally-administered sCT-minispheres containing CG (45μmol/kg) and coated with Eudragit®. In conclusion, the SmPill® technology is a potential dosage form for several peptides when formulated with PEs and coated for regional delivery. PK data from instillations over-estimates oral bioavailability and poorly predicts rank ordering of formulations. PMID:27480451

  4. Reducing mortality in HIV-infected infants and achieving the 90–90–90 target through innovative diagnosis approaches

    Directory of Open Access Journals (Sweden)

    Shaffiq Essajee

    2015-12-01

    -to-child transmission. Facility-based SMS printers speed up the return of laboratory results and may be of value for other testing services apart from HIV infant diagnosis. Conclusions: New tools and strategies for HIV infant diagnosis could have a significant positive impact on the identification and retention of HIV-infected infants. In order to be most effective, national programmes should carefully consider which ideas to implement and how best to integrate novel strategies into existing systems. There is no single solution that will work everywhere. Rather, a number of approaches need to be considered and should be linked in order to achieve the greatest impact on the continuum of care from testing to treatment.

  5. NREL 2012 Achievement of Ethanol Cost Targets: Biochemical Ethanol Fermentation via Dilute-Acid Pretreatment and Enzymatic Hydrolysis of Corn Stover

    Energy Technology Data Exchange (ETDEWEB)

    Tao, L.; Schell, D.; Davis, R.; Tan, E.; Elander, R.; Bratis, A.

    2014-04-01

    For the DOE Bioenergy Technologies Office, the annual State of Technology (SOT) assessment is an essential activity for quantifying the benefits of biochemical platform research. This assessment has historically allowed the impact of research progress achieved through targeted Bioenergy Technologies Office funding to be quantified in terms of economic improvements within the context of a fully integrated cellulosic ethanol production process. As such, progress toward the ultimate 2012 goal of demonstrating cost-competitive cellulosic ethanol technology can be tracked. With an assumed feedstock cost for corn stover of $58.50/ton this target has historically been set at $1.41/gal ethanol for conversion costs only (exclusive of feedstock) and $2.15/gal total production cost (inclusive of feedstock) or minimum ethanol selling price (MESP). This year, fully integrated cellulosic ethanol production data generated by National Renewable Energy Laboratory (NREL) researchers in their Integrated Biorefinery Research Facility (IBRF) successfully demonstrated performance commensurate with both the FY 2012 SOT MESP target of $2.15/gal (2007$, $58.50/ton feedstock cost) and the conversion target of $1.41/gal through core research and process improvements in pretreatment, enzymatic hydrolysis, and fermentation.

  6. Energy and Sustainability: the European challenge of achieving the 2020 targets; Energia y sostenibilidad. El reto Europeo del logro de los objectivos del 2020

    Energy Technology Data Exchange (ETDEWEB)

    Bachiller Araque, J.

    2010-07-01

    The European Union and the energy sector should particularly face up to the triple challenge of increasing the security of supply, de carbonizing its production system and improving the competitiveness of its business network. Achieving the above objectives will involve relevant changes in the way to satisfy the primary energy demand and the electricity generation mix, the development and incorporation of new technologies, as well as the full completion of the internal energy market. Moreover, achieving the 20 targets in 2020 and perhaps a greater requirement on one of them will require increased energy efficiency in the whole chain, from production to consumption, as well as policies and initiatives on energy saving which are consistent with the maintenance of the current levels of welfare. (Author) 27 refs.

  7. EFFECT OF THE COMBINED ANTIHYPERTENSIVE THERAPY WITH TARGET BLOOD PRESSURE ACHIEVEMENT ON INTRARENAL BLOOD FLOW IN PATIENTS WITH TYPE 2 DIABETES

    Directory of Open Access Journals (Sweden)

    O. A. Koshel'skaya

    2012-01-01

    Full Text Available Aim. To compare the dynamics of intrarenal vascular resistance (IRVR, circadian blood pressure (BP profile and glomerular filtration rate (GFR in patients with arterial hypertension (HT and type 2 diabetes mellitus (DM who achieved the target BP levels (<130/80 mmHg due to long-term combined antihypertensive therapy with or without renin-angiotensin-aldosterone system (RAAS inhibitors. Material and methods. Patients (n=61 with HT and DM without clinical symptoms of nephroangiopathy were included into the open randomized study , 59 of these patients completed study. Patients of Group 1 (n=41 received therapy with valsartan (n=20, 80–160 mg/day , or perindopril (n=21, 5–10 mg/day , in combination with indapamide retard, 1.5 mg/day , and amlodipine, 5–10 mg/day. Patients of Group 2 (n=18 received amlodipine (5–10 mg/day in combination with indapamide retard (1.5 mg/day and metoprolol succinate (50–100 mg/day. Initially and after 30–32 weeks of therapy the following examinations were performed: duplex ultrasound scanning of the main renal (MRA and intrarenal arteries (IRA with resistive index (RI calculation, ambulatory BP monitoring (ABPM, GFR calculation (by Cockcroft-Gault formula. Results. The target BP levels were achieved in all patients of both groups. Patient’s baseline characteristics including age, sex, duration of disease, office BP , GFR, RI in MRA and IRA did not differ in the groups as well as decrease in office BP due to treatment. However patients of Group 2 had higher levels of systolic BP and systolic BP load at night time than these in patients of Group 1 during all period of the treatment. In patients of Group 2 RI in MRA and arcuate IRA were increased from 0.67±0.06 to 0.69±0.06 (p=0.02 and from 0.62±0.07 to 0.64±0.06 (p=0.02, respectively. The increase in IRA was positively associated with systolic BP at night time in these patients (r=0.6; p=0.01. There were no significant changes of IRA in Group 1 totally

  8. Achieving stringent climate targets. An analysis of the role of transport and variable renewable energies using energy-economy-climate models

    Energy Technology Data Exchange (ETDEWEB)

    Pietzcker, Robert Carl

    2014-07-01

    Anthropogenic climate change is threatening the welfare of mankind. Accordingly, policy makers have repeatedly stated the goal of slowing climate change and limiting the increase of global mean temperature to less than 2 C above pre-industrial times (the so-called ''two degree target''). Stabilizing the temperature requires drastic reductions of greenhouse gas (GHG) emissions to nearly zero. As the global system of energy supply currently relies on fossil fuels, reducing GHG emissions can only be achieved through a full-scale transformation of the energy system. This thesis investigates the economic requirements and implications of different scenarios that achieve stringent climate mitigation targets. It starts with the analysis of characteristic decarbonization patterns and identifies two particularly relevant aspects of mitigation scenarios: deployment of variable renewable energies (VRE) and decarbonization of the transport sector. After investigating these fields in detail, we turned towards one of the most relevant questions for policy makers and analyzed the trade-off between the stringency of a climate target and its economic requirements and implications. All analyses are based on the improvement, application, comparison, and discussion of large-scale IAMs. The novel ''mitigation share'' metric allowed us to identify the relevance of specific technology groups for mitigation and to improve our understanding of the decarbonization patterns of different energy subsectors. It turned out that the power sector is decarbonized first and reaches lowest emissions, while the transport sector is slowest to decarbonize. For the power sector, non-biomass renewable energies contribute most to emission reductions, while the transport sector strongly relies on liquid fuels and therefore requires biomass in combination with carbon capture and sequestration (CCS) to reduce emissions. An in-depth investigation of the solar power

  9. Achieving stringent climate targets. An analysis of the role of transport and variable renewable energies using energy-economy-climate models

    International Nuclear Information System (INIS)

    Anthropogenic climate change is threatening the welfare of mankind. Accordingly, policy makers have repeatedly stated the goal of slowing climate change and limiting the increase of global mean temperature to less than 2 C above pre-industrial times (the so-called ''two degree target''). Stabilizing the temperature requires drastic reductions of greenhouse gas (GHG) emissions to nearly zero. As the global system of energy supply currently relies on fossil fuels, reducing GHG emissions can only be achieved through a full-scale transformation of the energy system. This thesis investigates the economic requirements and implications of different scenarios that achieve stringent climate mitigation targets. It starts with the analysis of characteristic decarbonization patterns and identifies two particularly relevant aspects of mitigation scenarios: deployment of variable renewable energies (VRE) and decarbonization of the transport sector. After investigating these fields in detail, we turned towards one of the most relevant questions for policy makers and analyzed the trade-off between the stringency of a climate target and its economic requirements and implications. All analyses are based on the improvement, application, comparison, and discussion of large-scale IAMs. The novel ''mitigation share'' metric allowed us to identify the relevance of specific technology groups for mitigation and to improve our understanding of the decarbonization patterns of different energy subsectors. It turned out that the power sector is decarbonized first and reaches lowest emissions, while the transport sector is slowest to decarbonize. For the power sector, non-biomass renewable energies contribute most to emission reductions, while the transport sector strongly relies on liquid fuels and therefore requires biomass in combination with carbon capture and sequestration (CCS) to reduce emissions. An in-depth investigation of the solar power

  10. 推进总量减排达标打造绿色石化企业%Build Green Petrochemical Company by Achieving Emission Target

    Institute of Scientific and Technical Information of China (English)

    崔文峰; 王利红; 辛世希

    2015-01-01

    兰州石化将总量减排指标细化分解,制定出2010—2015年总量减排计划,以工程减排、技术减排、管理减排为手段,逐年逐项落实减排措施,推进了总量减排目标的实现。通过核实总量基数,研究减排政策,落实减排方案,细化减排措施,落实工程减排总量核查;开展工程项目完善和技术攻关,强化环保体系建设和过程控制,建立监督考核机制,实现环保设施稳定运行,企业排放达标水平稳步升级。2013年污染物排放强度较2010年降低50%~60%,主要污染物所占兰州市排放比例由2010年的20% 以上降低到3%~9%左右,环境质量大幅改善,清洁化、绿色化、可持续发展能力得到全面提升。%Total emission reduction plan of the company for the years from 2010 to 2015 is worked out through breakdown of total emission reduction target, in a bid to implement engineering, technical and management measures step by step and ifnally achieve the total target. Now the enterprise’s target-achieving capability has steadily improved via measures including verifying total emission base, studying emission reduction policy, perfecting engineering project, tackling technical problems, strengthening environmental protection system and process control, establishing supervision and examination mechanism and realizing stable operation of environmental protection facilities. Its pollutant emission intensity in 2013 is 50 %-60 % lower than that in 2010, and main pollutants proportion in the emission of Lanzhou city is reduced to 3 %-9 % from 20 % in 2010. Thus the environmental quality and the overall clean, green and sustainable development capability has been signiifcantly promoted.

  11. Split vector systems for ultra-targeted gene delivery: a contrivance to achieve ethical assurance of somatic gene therapy in vivo.

    Science.gov (United States)

    Tolmachov, Oleg E

    2014-08-01

    Tightly controlled spatial localisation of therapeutic gene delivery is essential to maximize the benefits of somatic gene therapy in vivo and to reduce its undesired effects on the 'bystander' cell populations, most importantly germline cells. Indeed, complete ethical assurance of somatic gene therapy can only be achieved with ultra-targeted gene delivery, which excludes the risk of inadvertent germline gene transfer. Thus, it is desired to supplement existing strategies of physical focusing and biological (cell-specific) targeting of gene delivery with an additional principle for the rigid control over spread of gene transfer within the body. In this paper I advance the concept of 'combinatorial' targeting of therapeutic gene transfer in vivo. I hypothesize that it is possible to engineer complex gene delivery vector systems consisting of several components, each one of them capable of independent spread within the human body but incapable of independent facilitation of gene transfer. As the gene delivery augmented by such split vector systems would be reliant on the simultaneous availability of all the vector system components at a predetermined body site, it is envisaged that higher order reaction kinetics required for the assembly of the functional gene transfer configuration would sharpen spatial localisation of gene transfer via curtailing the blurring effect of the vector spread within the body. A particular implementation of such split vector system could be obtained through supplementing a viral therapeutic gene vector with a separate auxiliary vector carrying a non-integrative and non-replicative form of a gene (e.g., mRNA) coding for a cellular receptor of the therapeutic vector component. Gene-transfer-enabling components of the vector system, which would be delivered separately from the vector component loaded with the therapeutic gene cargo, could also be cell-membrane-insertion-proficient receptors, elements of artificial transmembrane channels

  12. Win-win emissions reductions : smart transportation emission reduction strategies can achieve Kyoto targets and provide other economic, social and environmental benefits

    Energy Technology Data Exchange (ETDEWEB)

    Litman, T.

    2005-12-02

    This paper identified 12 transportation solutions that provide a combination of economic, social and environmental benefits. The win-win strategies are cost-effective, technically feasible policy reforms that correct market distortions which promote inefficient travel patterns. In addition to energy conservation and reducing pollution and traffic congestion, the strategies save on road and parking facilities, promote traffic safety and consumer savings, and improve mobility for non-drivers. The basic economic principles that make these benefits possible were examined. The proposed solutions create a more equitable and efficient transportation system that supports economic development and helps achieve other strategic planning objectives. The strategies include planning reforms; pay-as-you-drive pricing; parking cash-out; parking pricing; road pricing; transportation demand management programs; transit and ride-share improvements; walking and cycling improvements; smart growth; freight transport management; car sharing and revenue-neutral tax shifting. The author claims that if fully implemented, these strategies could reduce motor vehicle emissions and other costs by 30 to 50 per cent, depending on geographic, demographic and economic conditions. It was suggested that the approach could help meet Kyoto emission reduction targets while promoting economic development and increasing consumer benefits. 14 refs., 4 tabs., 2 figs.

  13. Trends and implications for achieving VISION 2020 human resources for eye health targets in 16 countries of sub-Saharan Africa by the year 2020

    OpenAIRE

    Palmer, JJ; Chinanayi, F; Gilbert, A.; Pillay, D.; Fox, S; Jaggernath, J; Naidoo, K.; Graham, R.; Patel, D.; Blanchet, K

    2014-01-01

    Background Development of human resources for eye health (HReH) is a major global eye health strategy to reduce the prevalence of avoidable visual impairment by the year 2020. Building on our previous analysis of current progress towards key HReH indicators and cataract surgery rates (CSRs), we predicted future indicator achievement among 16 countries of sub-Saharan Africa by 2020. Methods Surgical and HReH data were collected from national eye care programme coordinators on six practitioner...

  14. The energy intensity target in China's 11th Five-Year Plan period-Local implementation and achievements in Shanxi Province

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Daisheng, E-mail: daisheng.zhang@kjemi.uio.no [Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, 0315 Oslo (Norway); Aunan, Kristin [Center for International Climate and Environmental Research-Oslo (CICERO), P.O. Box 1129, Blindern, N-0318 Oslo (Norway); Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, 0315 Oslo (Norway); Martin Seip, Hans [Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, 0315 Oslo (Norway); Center for International Climate and Environmental Research-Oslo (CICERO), P.O. Box 1129, Blindern, N-0318 Oslo (Norway); Vennemo, Haakon [Oslo University College, P.O. Box 4, St. Olavs plass, 0130 Oslo (Norway)

    2011-07-15

    Facing the mounting pressure on energy security and increasing environmental concerns about air pollution and climate change, the Chinese government set a mandatory goal of 20% reduction of energy intensity in its 11th Five-Year Plan period (FYP, 2006-2010). In this paper we use Shanxi province to illustrate how policies and measures are implemented in practice at a provincial level as a response to the National FYP issued by the central government. Local policies are described and their effects are analyzed. We compare reported energy saving achievements with our own estimates and conclude that the achievements in Shanxi probably have been substantial since the start of the 11th FYP period. The most important measures taken by provincial and local governments seem to be in the secondary sector, such as Top-200/Top-1000 program and phasing out outdated technologies. However, Shanxi has still a long way to go to achieve satisfactory energy use. Further improvement of energy intensity will require continuing efforts. Although many measures are necessary, improving the energy efficiency in heavy industries and reducing the dependence on these industries should be particularly effective. - Highlights: > We use Shanxi province to illustrate how local policies respond to the National FYP. > Energy saving in Shanxi has been substantial since the start of the 11th FYP. > Assumptions about baseline energy use strongly affects energy saving estimates. > The most important measures taken by local governments are in the secondary sector. > Further improvement of energy intensity will require efforts especially in heavy industries.

  15. Raising Student Achievement Levels Through Target-setting and Academic Monitoring: A Case Study of Developments at Key Stage 3 in a Secondary School

    OpenAIRE

    Male, T.; Berge, J.

    1998-01-01

    Evidence for the conclusions and recommendations are based on interviews with tutors and students from Year 8 conducted by the Head of Year, who then provides an overview from her perspective. The findings are contrasted against the examples of effective target-setting provided by the DfEE Standards and Effectiveness Unit (DfEE, 1998b) and the Office for Standards in Education (Ofsted, 1996). The new scheme is also reviewed in the light of the call for equal opportunities by, amongst others, ...

  16. The central importance of the EU emission trading scheme for achievement of the German climate protection target of 40% until 2020; Die zentrale Bedeutung des EU-Emissionshandels zur Erreichung des deutschen Klimaziels in Hoehe von 40 % bis 2020

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, Hauke; Cludius, Johanna

    2014-02-15

    Both Germany and the European Union have set themselves targets for the reduction of greenhouse gas (GHG) emissions. The EU was the forerunner in 2008 when it adopted the Climate and Energy package and set a target of reducing GHG emissions by 20 % by 2020 compared to 1990. Two years later, Germany adopted a range of national GHG targets in the context of the German government's Energy Concept. This includes a 40% emissions reduction target to be met by 2020. One of the main instruments for achieving GHG emissions reduction targets is the EU Emissions Trading Scheme (EU ETS), which covers all large industrial and combustion installations in Europe. According to the agreement made in 2008 (Climate and Energy Package), the effort to achieve the EU's 20 % reduction target by 2020 was split between the ETS sector (2/3 of the reduction effort, representing a 21 % reduction in GHG emissions for installations covered under the ETS compared to 2005) and the non-ETS sector (1/3 of the reduction effort, representing a 10 % reduction compared to 2005). Logically, GHG emissions reductions occurring in German ETS installations count both towards the EU and the national target. This research project has been commissioned to analyse whether the ETS in its cur-rent design can contribute its fair share in efforts to meet the national emissions reduc-tion target. This question is particularly relevant in light of the following considerations: - The new German Coalition Agreement, signed in December 2013, reiterated the national target of a 40 % reduction of GHG emissions by 2020 compared to 1990 levels. - At the same time, the new Coalition Agreement stated that changes to the ETS are only to be considered if the EU GHG emissions reduction target will not be met. - There is a surplus of CO2 allowances on the ETS market, which undermines the credibility of the instrument as well as the integrity of the emissions reduction tar-gets (both European and national). At the same

  17. Climate cure 2020. Measures and instruments for achieving Norwegian climate targets to 2020; Klimakur 2020. Tiltak og virkemidler for aa naa norske klimamaal mot 2020

    Energy Technology Data Exchange (ETDEWEB)

    2010-07-01

    In this scenario, the analysis shows how international climate change agreements and the population's attitude to climate-friendly actions could affect Norway's ability to achieve the objectives of national emission reductions. Political feasibility, technology and carbon price may vary according to how forces will move in future. Some measures to reduce greenhouse gas emissions may be more robust against future uncertainties than others. Scenario analysis can therefore provide useful perspectives when instruments should be implemented to reduce greenhouse gas emissions in the years ahead. (AG)

  18. Effectiveness of Powerpoint Presentation On Students’ Cognitive Achievement in Technical Drawing

    Directory of Open Access Journals (Sweden)

    Amosa Isiaka Gambari

    2015-10-01

    Full Text Available This paper discusses importance of technology education and evidence of declining performance of junior secondary school students in basic technology subject. Benefits of PowerPoint presentation in classroom instruction as a means to improve classroom teaching in the developing countries are also discussed. The effectiveness of PowerPoint Presentation (PPT for teaching Technical Drawing concepts in Basic Technology was determined using a pretest-posttest, non-equivalent, non-randomized experimental group design. A 2x2x3 factorial design was employed. One hundred JSS 1 students (53 male and 47 female categorized into 29 high, 54 medium and 17 low achievers from two secondary schools in Abuja Metropolis formed the sample. The schools were randomly assigned to experimental and control groups. The experimental group was taught some selected concepts from Technical Drawing using PowerPoint Presentation (PPT while Chalkboard method (CB was used for the control group. A validated Technical Drawing Achievement Test (TDAT comprising a 25-item multiple-choice test was employed for data collection. The reliability coefficient of TDAT was .88 using Kuder-Richardson (KR-20. The hypotheses were tested using ANCOVA and Sidak post-hoc analysis. Results revealed that the students taught with PPT performed better than their counterparts taught with CB. Also, high achievers performed better than medium and low achievers respectfully. The PPT was found also to be gender friendly. Based on the findings, it was recommended that the use of PPT should be encouraged in Nigerian schools.

  19. Achieving the salt intake target of 6 g/day in the current food supply in free-living adults using two dietary education strategies.

    Science.gov (United States)

    Ireland, Dani-Maree; Clifton, Peter M; Keogh, Jennifer B

    2010-05-01

    There are national targets for salt intake of 6 g salt/day in Australia and the United States. Despite this, there is limited knowledge about the effectiveness of dietary education in reducing salt intake to this level. The objective of this study was to investigate whether dietary education enabled a reduction in salt consumption. In an 8-week parallel study, 49 healthy free-living adults were recruited from the Adelaide community by newspaper advertisement. In a randomized parallel design, participants received dietary education to choose foods identified by either Australia's National Heart Foundation Tick symbol or by the Food Standards Australia and New Zealand's low-salt guideline of 120 mg sodium/100 g food. Sodium excretion was assessed by 24-hour urinary sodium collections at baseline and weeks 4 and 8. Participants' experiences of following the education strategies were recorded by self-administered questionnaire. These data were collected between August and October 2008. Forty-three participants completed the study. After 8 weeks, urinary sodium excretion decreased from 121+/-50 to 106+/-47 mmol/24 hours (7.3+/-3.0 to 6.4+/-2.8 g salt/24 hours) in the Tick group and from 132+/-44 to 98+/-50 mmol/24 hours (7.9+/-2.6 to 6.0+/-3.0 g salt/24 hours) in the Food Standards Australia New Zealand group (Pfood choice, difficulty when eating out, and increased time associated with identifying foods. In conclusion, dietary sodium reduction is possible among free-living individuals who received dietary advice. PMID:20430138

  20. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2016-01-01

    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...... to be harmonized in order for a global company to perceive e-Customs as standardized. In doing so, they contribute an explanation of the challenges associated with using a standardization mechanism for harmonizing socio-technical information systems....

  1. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2014-01-01

    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...... to be harmonized in order for a global company to perceive e-Customs as standardized. In doing so, they contribute an explanation of the challenges associated with using a standardization mechanism for harmonizing socio-technical information systems....

  2. European climate targets achievable without nuclear power

    OpenAIRE

    Kemfert, Claudia; Gerbaulet, Clemens; von Hirschhausen, Christian; Lorenz, Casimir; Reitz, Felix

    2015-01-01

    The upcoming Climate Change Conference in Paris will once again highlight the need for action to reduce global greenhouse gas emissions in order to mitigate climate change. The relevant global energy scenarios are often still based on the assumption that the expansion of nuclear power can contribute to climate change mitigation. The spiraling investment and operating costs of nuclear plants, the unresolved issues concerning the dismantling of these plants and permanent storage of nuclear wast...

  3. 中国碳减排目标的可达性:能源政策与经济发展%The Achievability of China's Climate Target:Energy Policy and Economic Development

    Institute of Scientific and Technical Information of China (English)

    刘磊

    2012-01-01

    In November of 2009, China's State Council announced that the country will cut its carbon intensity ?carbon emissions per unit of gross domestic product (GDP) ?by 40% -45% from 2005 levels by 2020. It is of great significance for combating climate change of China and the world that whether China will achieve this target. This article analyzed the history and current status of energy consumption and economic development of China, the main energy policies that have been adopted and predicted if China would achieve carbon intensity reduction target under different scenarios. The result indicated that it is very possible that China will achieve the target but pointed energy policies are still needed. Finally according to above analysis, the article provided corresponding policy recommendations for the energy consumption and economic development of China in following years. That is, the governments should increase scientific and technological research expenditure, continue eliminating lagging behind productivity and promote the application of advanced technologies; continue readjusting industrial structure and increasing the proportion of tertiary industry; and promote the marketization of energy price.%2009年11月,中国国务院宣布到2020年,在2005年的基础之上将碳排放强度,即单位GDP二氧化碳排放量降低40%~45%.这一目标能否达成对于中国以及全球抵御气候变化都将产生深刻影响.分析我国能源消耗和经济发展的历史和现状,系统梳理到目前为止我国所制定和实施的能源政策,并结合情景分析预测了我国能否达到既定的碳排放强度削减目标.结果表明,我国实现减排目标是乐观的,但仍需要有针对性的政策导向.最后根据以上分析,对我国下一阶段的能源消耗和经济发展政策提出了相应建议,即加大科技支出,继续淘汰落后产能,推动先进生产技术应用;加大产业结构调整力度,大力发展第三产业;推动能源价格市场化进程.

  4. [EFFICACY OF STANDARD TWO-YEAR COMPREHENSIVE THERAPY TO ACHIEVE TARGET BLOOD PRESSURE AND REGRESSION DEGREES OF REMODELING OF THE LEFT VENTRICULAR HYPERTROPHY IN PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION WITH COMORBID HYPERTENSION].

    Science.gov (United States)

    Denesiuk, E V

    2015-01-01

    The study involved 23 men after acute myocardial infarction (AMI) with comorbid arterial hypertension (AH). Mean age of patients was 56.7 years. Recurrent myocardial infarction was determined in 38.4%, cardiac failure I-III functional classes--100% of the cases. All patients underwent clinical examination, electrocardiography and echocardiography, blood lipid profile. Standard comprehensive treatment for two years included an perindopril 5-10 mg/day, beta-blocker bisoprolol--5-10 mg/day, antisclerotic drug atorvastatin--20 mg/day and aspirin--75 mg/day. The patients after treatment was determined by a gradual increase towards the target of AT at 3, 6 and 12 to 24 months. Concentric left ventricular hypertrophy (LVH) before treatment was determined in 47.8%, eccentric--in 52.2% of patients. In the study of degrees of LVH I (initial) the extent to treatment was determined by 4.3%, II (moderate)--26.1%, III (large)--at 69.6%, indicating the development of cardiac remodeling. After the treatment was determined by marked reduction III (large) degree and transfer it in the II (moderate) and I (small) degree of left ventricular hypertrophy due to more or less pronounced changes remodeling left ventricular. The obtained data allow a more detailed and adequately assess the structural and functional outcome variables and determine the regression of myocardial hypertrophy in the background to achieve target blood pressure, which is important in practical cardiology.

  5. [EFFICACY OF STANDARD TWO-YEAR COMPREHENSIVE THERAPY TO ACHIEVE TARGET BLOOD PRESSURE AND REGRESSION DEGREES OF REMODELING OF THE LEFT VENTRICULAR HYPERTROPHY IN PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION WITH COMORBID HYPERTENSION].

    Science.gov (United States)

    Denesiuk, E V

    2015-01-01

    The study involved 23 men after acute myocardial infarction (AMI) with comorbid arterial hypertension (AH). Mean age of patients was 56.7 years. Recurrent myocardial infarction was determined in 38.4%, cardiac failure I-III functional classes--100% of the cases. All patients underwent clinical examination, electrocardiography and echocardiography, blood lipid profile. Standard comprehensive treatment for two years included an perindopril 5-10 mg/day, beta-blocker bisoprolol--5-10 mg/day, antisclerotic drug atorvastatin--20 mg/day and aspirin--75 mg/day. The patients after treatment was determined by a gradual increase towards the target of AT at 3, 6 and 12 to 24 months. Concentric left ventricular hypertrophy (LVH) before treatment was determined in 47.8%, eccentric--in 52.2% of patients. In the study of degrees of LVH I (initial) the extent to treatment was determined by 4.3%, II (moderate)--26.1%, III (large)--at 69.6%, indicating the development of cardiac remodeling. After the treatment was determined by marked reduction III (large) degree and transfer it in the II (moderate) and I (small) degree of left ventricular hypertrophy due to more or less pronounced changes remodeling left ventricular. The obtained data allow a more detailed and adequately assess the structural and functional outcome variables and determine the regression of myocardial hypertrophy in the background to achieve target blood pressure, which is important in practical cardiology. PMID:27491146

  6. 科技成果产业化目标市场评估与选择模型研究%Research on Evaluation and Selection Model of Target Market for Industrialization of Scientific and Technological Achievements of the Institutes

    Institute of Scientific and Technical Information of China (English)

    刘书庆; 苏秦; 陈丹丹

    2012-01-01

    Based on analysis of the current situation of target market evaluating and selecting both at home and abroad, this paper firstly constructed the target market evaluation and selection process control model based on the theory of system dy-namics(SD). Secondly, we cleared the system boundary and according to the method of strategic environmental assessment 24 marketing performance factors were comprehensively identified as the benchmark variables, which were from macro environment support level, industry environment challenges and internal resources satisfaction. Then this study built causal diagrams, system flow chart and quantitative equation of the target markets development which constituted the SD system structure model, and also we characterized the dynamic feedback laws between factors and industrialization marketing performance of scientific and technological achievements. Finally, according to industrialization of polymer material, vensim simulation was carried out on its target market evaluation and selection SD model. At the same time, we put forward the selecting option which based on the simulated results of target market's developmental level and stability, and offer some help to improve target market evaluating and selecting of industrialization of science and technology production.%在分析国内外目标市场评估与选择理论研究现状及其存在问题的基础上,构建了基于系统动力学(SD)的目标市场评估与选择过程控制模型;明确了科技成果产业化目标市场评估系统边界,并采用战略环境评估方法,从宏观环境支持程度、产业环境威胁力及内部资源条件满足程度等方面识别出24个营销绩效影响因素,形成了SD模型的基准变量;然后构建了科技成果产业化目标市场发展提升过程因果关系图、流图、量化分析方程,形成了SD系统结构模型,刻画出影响因素与科技成果产业化营销绩效的动态反馈规律;最后结合某高分

  7. Environmental impact of elemental concentration and distribution in waters, soils and plants along the Lokoja-Abuja pipeline routes of Bida Basin, northwestern Nigeria

    Science.gov (United States)

    Boboye, Olugbenga A.; Abumere, Iyior O.

    2014-11-01

    This paper presents environmental study carried out to evaluate the impacts of elements' concentrations in water, soil, plants and the level of environmental damage. This is to establish the rate of pollution and degree of enrichment to enhance delineation of highly polluted areas along the pipeline routes. It was achieved by determining their spatial distribution, concentration and/or occurrences as well as the possible sources of enrichment. Forty-six (46) surface water samples were collected during the dry season while thirty (30) surface water samples were collected in the wet season respectively. The sampling was systematically carried out at diverse locations along the streams and major rivers to broadly cover the variation in the area. Fifty-one (51) soil samples were collected during dry and wet seasons to determine the texture, heavy metal concentration and physico-chemical characteristics. Thirty (30) and twenty-six (26) samples of stream and river sediments were also collected during the dry and wet seasons for physico-chemical characterization, texture and heavy metal concentrations. Ten plant tissues were collected and analysed to ascertain the rate of absorption. The results of the surface water during the dry and wet seasons showed slight acidity while the Electrical Conductivity revealed that the major ions are higher in the dry season. The major anions and cations accounted for about 71% and 29% of the Total Dissolved Solids respectively. The higher concentrations of Fe in the stream sediments and soil than that in the water and plant tissues suggest the weathering of oolitic, pisolitic and argillaceous ironstone within the area. Concentration of NH4 emanate from anthropogenic sources Textural classification revealed sand dominated soil which confirmed that the soil and stream sediment are autochthonous. The concentration of heavy metals and cations for both seasons in the plant tissues showed no discrepancy. The hydro-chemical facies

  8. Low rates of both lipid-lowering therapy use and achievement of low-density lipoprotein cholesterol targets in individuals at high-risk for cardiovascular disease across Europe.

    Directory of Open Access Journals (Sweden)

    Julian P Halcox

    Full Text Available To analyse the treatment and control of dyslipidaemia in patients at high and very high cardiovascular risk being treated for the primary prevention of cardiovascular disease (CVD in Europe.Data were assessed from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA, ClinicalTrials.gov identifier: NCT00882336, which included a randomly sampled population of primary CVD prevention patients from 12 European countries (n = 7641. Patients' 10-year risk of CVD-related mortality was calculated using the Systematic Coronary Risk Evaluation (SCORE algorithm, identifying 5019 patients at high cardiovascular risk (SCORE ≥5% and/or receiving lipid-lowering therapy, and 2970 patients at very high cardiovascular risk (SCORE ≥10% or with diabetes mellitus. Among high-risk individuals, 65.3% were receiving lipid-lowering therapy, and 61.3% of treated patients had uncontrolled low-density lipoprotein cholesterol (LDL-C levels (≥2.5 mmol/L. For very-high-risk patients (uncontrolled LDL-C levels defined as ≥1.8 mmol/L these figures were 49.5% and 82.9%, respectively. Excess 10-year risk of CVD-related mortality (according to SCORE attributable to lack of control of dyslipidaemia was estimated to be 0.72% and 1.61% among high-risk and very-high-risk patients, respectively. Among high-risk individuals with uncontrolled LDL-C levels, only 8.7% were receiving a high-intensity statin (atorvastatin ≥40 mg/day or rosuvastatin ≥20 mg/day. Among very-high-risk patients, this figure was 8.4%.There is a considerable opportunity for improvement in rates of lipid-lowering therapy use and achievement of lipid-level targets in high-risk and very-high-risk patients being treated for primary CVD prevention in Europe.

  9. A survey on the current status of type 2 diabetic patients who failed to achieve the glycemic control target%2型糖尿病血糖控制未达标患者现状调查报告

    Institute of Scientific and Technical Information of China (English)

    陈名道; 潘长玉; 杨立勇; 李延兵; 肖新华; 冯波; 张秋梅; 李成江

    2011-01-01

    目的 调查2型糖尿病血糖未达标患者的现状,为制定应对策略提供理论依据.方法 201.年8至10月,收集全国26个城市181家医院血糖未达标的2型糖尿病患者进行问卷调查,调查未达标患者的血糖水平、生活方式干预、血糖监测、药物使用情况等,得到资料比较完整的问卷3 861份,分析患者未达标原因.结果 在统计的未达标患者中,HbA1c均值7.9%,空腹血糖均值8.2 mmol/L,餐后血糖均值11.5 mmol/L.生活方式干预方面,仅25.6%的患者能按医嘱严格进行饮食控制,44.5%的患者基本不进行体育锻炼.分别有35.8%和47.8%的患者不进行空腹和餐后血糖的监测.60岁以上的患者,血糖控制水平与其他年龄组并无差别,但其低血糖发生率高达35.5%,较其他两组(分别为20.8%和21.4%)明显为高(均P<0.05).药物治疗方面,单药治疗及联合治疗患者比例分别为46.1%和51.7%.>60岁的老年组联合用药比例更高(58.7%,与其他年龄组比,P<0.05).75%的患者进行了治疗方案的调整.结论 药物治疗方案不够强化或不适当是患者血糖未达标的主要原因;另外,生活方式不佳,血糖监测不够,患者依从性差也是血糖未达标的重要原因.对于未达标患者,需要进一步强化患者教育,加强生活方式干预,选择更加强化,同时安全、依从性好的降糖治疗方案.对于老年患者降糖的目标值应适当放宽.%Objective To investigate the current status of type 2 diabetic patients who failed to achieve the glycemic control target, and provide theoretic evidences for making corresponding strategies. Methods The 2 diabetic patients who failed to reach the glycemic target were recruited from 181 hospitals in 26 cities and received a standard questionnaire, the conditions of their blood glucose level, lifestyle intervention, blood sugar monitoring, and drug therapy were recorded. Totally 3 861 questionnaires with complete information were collected

  10. Graded Achievement, Tested Achievement, and Validity

    Science.gov (United States)

    Brookhart, Susan M.

    2015-01-01

    Twenty-eight studies of grades, over a century, were reviewed using the argument-based approach to validity suggested by Kane as a theoretical framework. The review draws conclusions about the meaning of graded achievement, its relation to tested achievement, and changes in the construct of graded achievement over time. "Graded…

  11. Post2012 climate regime options for global GHG emission reduction. Analysis and evaluation of regime options and reduction potential for achieving the 2 degree target with respect to environmental effectiveness, costs and institutional aspects

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, Katja; Graichen, Jakob; Healy, Sean [Oeko-Institut, Inst. fuer Angewandte Oekologie e.V., Freiburg im Breisgau (Germany); Schleich, Joachim; Duscha, Vicki [Fraunhofer-Institut fuer Systemtechnik und Innovationsforschung (ISI), Karlsruhe (Germany)

    2011-08-15

    This report explores the environmental and economic effects of the pledges submitted by industrialized and major developing countries for 2020 under the Copenhagen Accord and provides an in-depth comparison with results arrived at in other model analyses. Two scenarios reflect the lower (''weak'') and upper (''ambitious'') bounds of the Copenhagen pledges. In addition, two scenarios in accordance with the IPCC range for reaching a 2 C target are analyzed with industrialized countries in aggregate reducing their CO2 emissions by 30 % in 2020 compared to 1990 levels. For all four policy scenarios the effects of emission paths leading to a global reduction target of 50 % below 1990 levels in 2050 are also simulated for 2030. In addition, a separate scenario is carried out which estimates the costs of an unconditioned EU 30 % emission reduction target, i.e. where the EU adopts a 30 % emission reduction target in 2020 (rather than a 20 % reduction target), while all other countries stick with their ''weak'' pledges. Not included in the calculations is possible financial support for developing countries from industrialized countries as currently discussed in the climate change negotiations and laid out in the Copenhagen Accord. (orig.)

  12. Estimating achievement from fame

    OpenAIRE

    Simkin, M. V.; Roychowdhury, V. P.

    2009-01-01

    We report a method for estimating people's achievement based on their fame. Earlier we discovered (cond-mat/0310049) that fame of fighter pilot aces (measured as number of Google hits) grows exponentially with their achievement (number of victories). We hypothesize that the same functional relation between achievement and fame holds for other professions. This allows us to estimate achievement for professions where an unquestionable and universally accepted measure of achievement does not exi...

  13. 一种快速区域视频行检测方法的设计与实现%Achievement of Rapid Target Detection Algorithm Based on Video

    Institute of Scientific and Technical Information of China (English)

    陆蔚

    2011-01-01

    根据目前国内各种视频检测技术在电子警察系统上的应用,结合雷达目标检测算法,设计出具有背景自适应、目标跟踪等特点的一种快速区域视频行检测方法;该方法通过检测区域行亮度的变化,通过检测目标之间的相关处理来判断机动车是否违法,不仅能高效实现对汽车违规跨越道路中心黄线进行自动监测、记录,还为交通管理部门进行执法提供有力的证据并减少交通事故的发生;通过现场测试表明,该方法不仅准确率高,而且实时性很强,具有很大的实用价值.%According to the current domestic variety of video detection technology in the electronic police system combined with radar target detection method gives a Rapid Target video detection algorithm. The method of detection is realized through the change of line brightness in Regional Detection , through the line between target detection of related to judge whether the vehicle with illegal, It' s avaibable not only efficiently for automobile compasses across the yellow line on road center automatic monitoring and recording, also for traffic management to provide strong evidence, and reduce the number of traffic accidents. Experimental result shows that method can track the vehicles effectively and get a better time-consuming.

  14. Targeted Radionuclide Therapy

    Directory of Open Access Journals (Sweden)

    David Cheng

    2011-10-01

    Full Text Available Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the tumor prior to the therapy. Several different radiopharmaceuticals are currently being used by various administration routes and targeting mechanisms. This article aims to briefly review the current status of targeted radiotherapy as well as to outline the advantages and disadvantages of radionuclides used for this purpose.

  15. College Achievement and Earnings

    OpenAIRE

    Gemus, Jonathan

    2010-01-01

    I study the size and sources of the monetary return to college achievement as measured by cumulative Grade Point Average (GPA). I first present evidence that the return to achievement is large and statistically significant. I find, however, that this masks variation in the return across different groups of people. In particular, there is no relationship between GPA and earnings for graduate degree holders but a large and positive relationship for people without a graduate degree. To reconcile...

  16. CERN: Fixed target targets

    International Nuclear Information System (INIS)

    Full text: While the immediate priority of CERN's research programme is to exploit to the full the world's largest accelerator, the LEP electron-positron collider and its concomitant LEP200 energy upgrade (January, page 1), CERN is also mindful of its long tradition of diversified research. Away from LEP and preparations for the LHC proton-proton collider to be built above LEP in the same 27-kilometre tunnel, CERN is also preparing for a new generation of heavy ion experiments using a new source, providing heavier ions (April 1992, page 8), with first physics expected next year. CERN's smallest accelerator, the LEAR Low Energy Antiproton Ring continues to cover a wide range of research topics, and saw a record number of hours of operation in 1992. The new ISOLDE on-line isotope separator was inaugurated last year (July, page 5) and physics is already underway. The remaining effort concentrates around fixed target experiments at the SPS synchrotron, which formed the main thrust of CERN's research during the late 1970s. With the SPS and LEAR now approaching middle age, their research future was extensively studied last year. Broadly, a vigorous SPS programme looks assured until at least the end of 1995. Decisions for the longer term future of the West Experimental Area of the SPS will have to take into account the heavy demand for test beams from work towards experiments at big colliders, both at CERN and elsewhere. The North Experimental Area is the scene of larger experiments with longer lead times. Several more years of LEAR exploitation are already in the pipeline, but for the longer term, the ambitious Superlear project for a superconducting ring (January 1992, page 7) did not catch on. Neutrino physics has a long tradition at CERN, and this continues with the preparations for two major projects, the Chorus and Nomad experiments (November 1991, page 7), to start next year in the West Area. Delicate neutrino oscillation effects could become

  17. Explorations in achievement motivation

    Science.gov (United States)

    Helmreich, Robert L.

    1982-01-01

    Recent research on the nature of achievement motivation is reviewed. A three-factor model of intrinsic motives is presented and related to various criteria of performance, job satisfaction and leisure activities. The relationships between intrinsic and extrinsic motives are discussed. Needed areas for future research are described.

  18. Intelligence and Educational Achievement

    Science.gov (United States)

    Deary, Ian J.; Strand, Steve; Smith, Pauline; Fernandes, Cres

    2007-01-01

    This 5-year prospective longitudinal study of 70,000+ English children examined the association between psychometric intelligence at age 11 years and educational achievement in national examinations in 25 academic subjects at age 16. The correlation between a latent intelligence trait (Spearman's "g"from CAT2E) and a latent trait of educational…

  19. Setting and Achieving Objectives.

    Science.gov (United States)

    Knoop, Robert

    1986-01-01

    Provides basic guidelines which school officials and school boards may find helpful in negotiating, establishing, and managing objectives. Discusses characteristics of good objectives, specific and directional objectives, multiple objectives, participation in setting objectives, feedback on goal process and achievement, and managing a school…

  20. Sputter target

    Science.gov (United States)

    Gates, Willard G.; Hale, Gerald J.

    1980-01-01

    The disclosure relates to an improved sputter target for use in the deposition of hard coatings. An exemplary target is given wherein titanium diboride is brazed to a tantalum backing plate using a gold-palladium-nickel braze alloy.

  1. Achieving the Goals of Sports Organizations

    OpenAIRE

    Horal, Filip

    2009-01-01

    The theoretical part focuses on setting and achieving of goals in organizations in general and identifies specific performance objectives in sports organizations. In the practical part examines the process of setting targets and performance in sport organizations to Jindřichohradecko.

  2. Achieveing Organizational Excellence Through

    Directory of Open Access Journals (Sweden)

    Mehdi Abzari

    2009-04-01

    Full Text Available AbstractToday, In order to create motivation and desirable behavior in employees, to obtain organizational goals,to increase human resources productivity and finally to achieve organizational excellence, top managers oforganizations apply new and effective strategies. One of these strategies to achieve organizational excellenceis creating desirable corporate culture. This research has been conducted to identify the path to reachorganizational excellence by creating corporate culture according to the standards and criteria oforganizational excellence. The result of the so-called research is this paper in which researchers foundtwenty models and components of corporate culture and based on the Industry, organizational goals andEFQM model developed a model called "The Eskimo model of Culture-Excellence". The method of theresearch is survey and field study and the questionnaires were distributed among 116 managers andemployees. To assess the reliability of questionnaires, Cronbach alpha was measured to be 95% in the idealsituation and 0/97 in the current situation. Systematic sampling was done and in the pre-test stage 45questionnaires were distributed. A comparison between the current and the ideal corporate culture based onthe views of managers and employees was done and finally it has been concluded that corporate culture isthe main factor to facilitate corporate excellence and success in order to achieve organizational effectiveness.The contribution of this paper is that it proposes a localized –applicable model of corporate excellencethrough reinforcing corporate culture.

  3. FEWER HOURS MORE ACHIEVEMENTS

    Institute of Scientific and Technical Information of China (English)

    NingQuanxin; QiuLizhong

    2004-01-01

    The goal of this study is to improve instructional classes for “Extensive Reading”. We compare two approaches. The traditional method is based on the original procedure; the method we try is a “task-placemented” one. inspired by the method we try is a “task-placemented” one. inspired by the theory of “Tasks of Ascending Difficulty”.This paper provides a comparative evaluation of our experiments on Extensive Reading. Our aim is to resolve the logistical problem of heavy teaching loads and limited class hours, which often prevents English learners from fulfilling their study targets and our intended learning outcomes. In view of the experimental data,we have managed to establish a “feedback” to test the two hypotheses, and demonstrate that the new approach contributes to efficient acquisition of the information in the presented reading materials. Our study concludes with an interpretation of the function and merits of this approach.

  4. Achieving English Spoken Fluency

    Institute of Scientific and Technical Information of China (English)

    王鲜杰

    2000-01-01

    Language is first and foremost oral,spoken language,speaking skill is the most important one of the four skills(L,S,R,W)and also it is the most difficult one of the four skills. To have an all-round command of a language one must be able to speak and to understand the spoken language, it is not enough for a language learner only to have a good reading and writing skills. As Englisn language teachers, we need to focus on improving learners' English speaking skill to meet the need of our society and our country and provide learner some useful techniques to achieving their English spoken fluency. This paper focuses on the spoken how to improving learners speaking skill.

  5. Achieving diagnosis by consensus

    LENUS (Irish Health Repository)

    Kane, Bridget

    2009-08-01

    This paper provides an analysis of the collaborative work conducted at a multidisciplinary medical team meeting, where a patient’s definitive diagnosis is agreed, by consensus. The features that distinguish this process of diagnostic work by consensus are examined in depth. The current use of technology to support this collaborative activity is described, and experienced deficiencies are identified. Emphasis is placed on the visual and perceptual difficulty for individual specialities in making interpretations, and on how, through collaboration in discussion, definitive diagnosis is actually achieved. The challenge for providing adequate support for the multidisciplinary team at their meeting is outlined, given the multifaceted nature of the setting, i.e. patient management, educational, organizational and social functions, that need to be satisfied.

  6. Does inflation targeting make a difference?

    OpenAIRE

    Frederic S. Mishkin; Schmidt-Hebbel, Klaus

    2006-01-01

    Yes, as inferred from panel evidence for inflation-targeting countries and a control group of high-achieving industrial countries that do not target inflation. Our evidence suggests that inflation targeting helps countries achieve lower inflation in the long run, have smaller inflation response to oil-price and exchange-rate shocks, strengthen monetary policy independence, improve monetary policy efficiency, and obtain inflation outcomes closer to target levels. Some benefits of inflation tar...

  7. Treating rheumatoid arthritis to target

    DEFF Research Database (Denmark)

    Smolen, Josef S; Aletaha, Daniel; Bijlsma, Johannes W J;

    2010-01-01

    BACKGROUND: Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA). OBJECTIVE: /st> To develop recommendations for achieving optimal therapeutic outcomes in RA. METHODS...

  8. Achievement Goals and Achievement Emotions: A Meta-Analysis

    Science.gov (United States)

    Huang, Chiungjung

    2011-01-01

    This meta-analysis synthesized 93 independent samples (N = 30,003) in 77 studies that reported in 78 articles examining correlations between achievement goals and achievement emotions. Achievement goals were meaningfully associated with different achievement emotions. The correlations of mastery and mastery approach goals with positive achievement…

  9. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  10. Achieving strategic cost reduction in the OR.

    Science.gov (United States)

    Buchler, Richard

    2014-10-01

    Hospitals should be proactive insearching for ways to control operating room supply chain costs. A hospital can identify an overall supply cost savings goal by analyzing patient-encounter data for its 15 most costly procedures and identifying the dollar figure under which 25 percent of cases fall for each procedure. After establishing savings targets, the hospital can achieve its goals through a range of approaches. PMID:25647904

  11. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    hill, amanda; Leinikka Dall, Ole; Andersen, Frits Møller

    2014-01-01

    Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22......% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses...... how the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish...

  12. Attitude Towards Physics and Additional Mathematics Achievement Towards Physics Achievement

    Science.gov (United States)

    Veloo, Arsaythamby; Nor, Rahimah; Khalid, Rozalina

    2015-01-01

    The purpose of this research is to identify the difference in students' attitude towards Physics and Additional Mathematics achievement based on gender and relationship between attitudinal variables towards Physics and Additional Mathematics achievement with achievement in Physics. This research focused on six variables, which is attitude towards…

  13. Targeted Learning

    CERN Document Server

    van der Laan, Mark J

    2011-01-01

    The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the targe

  14. Relationships between Student, Teacher, and School Characteristics and Mathematics Achievement

    Science.gov (United States)

    Petty, Teresa; Wang, Chuang; Harbaugh, Adam P.

    2013-01-01

    A variety of factors contributes to student achievement in mathematics, including but not limited to student behaviors and student, teacher, and school characteristics. The purpose of this study was to explore which of these factors have an impact on student mathematics achievement. The target population for this study was North Carolina Algebra…

  15. Cherokee Culture and School Achievement.

    Science.gov (United States)

    Brown, Anthony D.

    1980-01-01

    Compares the effect of cooperative and competitive behaviors of Cherokee and Anglo American elementary school students on academic achievement. Suggests changes in teaching techniques and lesson organization that might raise academic achievement while taking into consideration tribal traditions that limit scholastic achievement in an…

  16. 提振精气神抢抓新机遇实现新跨越努力在“十二五”承前启后之年提前实现倍增目标在2013年集团工作会暨党委工作会上的报告(有删节)%Inspiring Essence and Spirit, Seizing New Opportunity,Achieving New Development, Making Great Efforts to Achieve the Output Value Doubling Target in Advance in the Continuity Year of Twelfth Five-Year Period ——A Speech made on the Company Working Conferen

    Institute of Scientific and Technical Information of China (English)

    董英

    2013-01-01

    The main tasks and achievements of CYMCO in production and management, foundation management, management control transformation, project construction, resource strategy, reform deepening, capital functioning, technological innovation, Party building and so on in 2012 are summarized in this paper, and the development targets and main tasks in 2013 are also studied and arranged.%总结集团2012年生产经营、基础管理、管控转型、项目建设、资源战略、深化改革、资本运作、科技创新、党的建设等方面的主要工作和取得的成绩.研究部署集团2013年发展目标和主要任务.

  17. Students' Achievement Goals, Learning-Related Emotions and Academic Achievement

    Directory of Open Access Journals (Sweden)

    Marko eLüftenegger

    2016-05-01

    Full Text Available In the present research, the recently proposed 3x2 model of achievement goals is tested and associations with achievement emotions and their joint influence on academic achievement are investigated. The study was conducted with 388 students using the 3x2 Achievement Goal Questionnaire including the six proposed goal constructs (task-approach, task-avoidance, self-approach, self-avoidance, other-approach, other-avoidance and the enjoyment and boredom scales from the Achievement Emotion Questionnaire. Exam grades were used as an indicator of academic achievement. Findings from CFAs provided strong support for the proposed structure of the 3x2 achievement goal model. Self-based goals, other-based goals and task-approach goals predicted enjoyment. Task-approach goals negatively predicted boredom. Task-approach and other-approach predicted achievement. The indirect effects of achievement goals through emotion variables on achievement were assessed using bias-corrected bootstrapping. No mediation effects were found. Implications for educational practice are discussed.

  18. The Sinuous Target

    Energy Technology Data Exchange (ETDEWEB)

    Zwaska, R. [Fermilab

    2015-06-01

    We report on the concept for a target material comprised of a multitude of interlaced wires of small dimension. This target material concept is primarily directed at high-power neutrino targets where the thermal shock is large due to small beam sizes and short durations; it also has applications to other high-power targets, particularly where the energy deposition is great or a high surface area is preferred. This approach ameliorates the problem of thermal shock by engineering a material with high strength on the micro-scale, but a very low modulus of elasticity on the meso-scale. The low modulus of elasticity is achieved by constructing the material of spring-like wire segments much smaller than the beam dimension. The intrinsic bends of the wires will allow them to absorb the strain of thermal shock with minimal stress. Furthermore, the interlaced nature of the wires provides containment of any segment that might become loose. We will discuss the progress on studies of analogue materials and fabrication techniques for sinuous target materials.

  19. Camouflage target reconnaissance based on hyperspectral imaging technology

    Science.gov (United States)

    Hua, Wenshen; Guo, Tong; Liu, Xun

    2015-08-01

    Efficient camouflaged target reconnaissance technology makes great influence on modern warfare. Hyperspectral images can provide large spectral range and high spectral resolution, which are invaluable in discriminating between camouflaged targets and backgrounds. Hyperspectral target detection and classification technology are utilized to achieve single class and multi-class camouflaged targets reconnaissance respectively. Constrained energy minimization (CEM), a widely used algorithm in hyperspectral target detection, is employed to achieve one class camouflage target reconnaissance. Then, support vector machine (SVM), a classification method, is proposed to achieve multi-class camouflage target reconnaissance. Experiments have been conducted to demonstrate the efficiency of the proposed method.

  20. The Predictiveness of Achievement Goals

    Directory of Open Access Journals (Sweden)

    Huy P. Phan

    2013-11-01

    Full Text Available Using the Revised Achievement Goal Questionnaire (AGQ-R (Elliot & Murayama, 2008, we explored first-year university students’ achievement goal orientations on the premise of the 2 × 2 model. Similar to recent studies (Elliot & Murayama, 2008; Elliot & Thrash, 2010, we conceptualized a model that included both antecedent (i.e., enactive learning experience and consequence (i.e., intrinsic motivation and academic achievement of achievement goals. Two hundred seventy-seven university students (151 women, 126 men participated in the study. Structural equation modeling procedures yielded evidence that showed the predictive effects of enactive learning experience and mastery goals on intrinsic motivation. Academic achievement was influenced intrinsic motivation, performance-approach goals, and enactive learning experience. Enactive learning experience also served as an antecedent of the four achievement goal types. On the whole, evidence obtained supports the AGQ-R and contributes, theoretically, to 2 × 2 model.

  1. The Mechanics of Human Achievement

    Science.gov (United States)

    Duckworth, Angela L.; Eichstaedt, Johannes C.; Ungar, Lyle H.

    2015-01-01

    Countless studies have addressed why some individuals achieve more than others. Nevertheless, the psychology of achievement lacks a unifying conceptual framework for synthesizing these empirical insights. We propose organizing achievement-related traits by two possible mechanisms of action: Traits that determine the rate at which an individual learns a skill are talent variables and can be distinguished conceptually from traits that determine the effort an individual puts forth. This approach takes inspiration from Newtonian mechanics: achievement is akin to distance traveled, effort to time, skill to speed, and talent to acceleration. A novel prediction from this model is that individual differences in effort (but not talent) influence achievement (but not skill) more substantially over longer (rather than shorter) time intervals. Conceptualizing skill as the multiplicative product of talent and effort, and achievement as the multiplicative product of skill and effort, advances similar, but less formal, propositions by several important earlier thinkers. PMID:26236393

  2. Mathematics Achievement in High- and Low-Achieving Secondary Schools

    Science.gov (United States)

    Mohammadpour, Ebrahim; Shekarchizadeh, Ahmadreza

    2015-01-01

    This paper identifies the amount of variance in mathematics achievement in high- and low-achieving schools that can be explained by school-level factors, while controlling for student-level factors. The data were obtained from 2679 Iranian eighth graders who participated in the 2007 Trends in International Mathematics and Science Study. Of the…

  3. Proactive Steering Toward Oriented Targets

    OpenAIRE

    Boulic, R

    2005-01-01

    In this paper we introduce a real-time steering controller ensuring the reach of a (possible mobile) target position and orientation, without requiring to build/update the full trajectory to that target. We name it the funnelling control. The final orientation is achieved through the continuous adjustment of the heading direction. This control mode is proactive in the sense that it anticipates the success/failure of the reach and adjusts the desired speed accordingly. Both features rely on an...

  4. Attribution theory in science achievement

    Science.gov (United States)

    Craig, Martin

    Recent research reveals consistent lags in American students' science achievement scores. Not only are the scores lower in the United States compared to other developed nations, but even within the United States, too many students are well below science proficiency scores for their grade levels. The current research addresses this problem by examining potential malleable factors that may predict science achievement in twelfth graders using 2009 data from the National Assessment of Educational Progress (NAEP). Principle component factor analysis was conducted to determine the specific items that contribute to each overall factor. A series of multiple regressions were then analyzed and formed the predictive value of each of these factors for science achievement. All significant factors were ultimately examined together (also using multiple regression) to determine the most powerful predictors of science achievement, identifying factors that predict science achievement, the results of which suggested interventions to strengthen students' science achievement scores and encourage persistence in the sciences at the college level and beyond. Although there is a variety of research highlighting how students in the US are falling behind other developing nations in science and math achievement, as yet, little research has addressed ways of intervening to address this gap. The current research is a starting point, seeking to identify malleable factors that contribute to science achievement. More specifically, this research examined the types of attributions that predict science achievement in twelfth grade students.

  5. Achieving Low Carbon Social Housing Through Innovation

    OpenAIRE

    Jones, Keith; Desai, Apeksha; Kaluarachchi, Yamuna

    2012-01-01

    Achieving a low carbon future continues to be one of the most challenging issues facing today’s built environment professionals. While significant advances have been made in the area of new build, the same cannot be said for the existing housing stock. In the UK 70% of the housing that will exist in 2050 has already been built. If the UK is to have any chance of meeting its 2050 carbon reduction targets, effective refurbishment strategies that significantly reduce the carbon footprint of exis...

  6. Achieving relativistic interaction intensities on Vulcan

    International Nuclear Information System (INIS)

    Vulcan is a multi-beam, Nd:glass, ultra-high power laser facility situated at the Central Laser Facility (CLF) in the Rutherford Appleton Laboratory (RAL). Recent developments have generated intensities on target up to 1020 W cm-2. This is achieved by delivering a high energy, ultra-short pulse using the technique of Chirped Pulse Amplification (CPA), in a high quality beam that is close to the diffraction limit. This report presents the current capabilities of the system and progress in the 1 Peta-watt upgrade of the facility. (authors)

  7. The Process of Science Achievement.

    Science.gov (United States)

    Papanastasiou, Constantinos; Papanastasiou, Elena C.

    2002-01-01

    Investigates the science achievement of 8th grade students in Cyprus by using a structural equation model with three exogenous constructs--family's educational background, reinforcements, and school climate, and three endogenous constructs--teaching, student attitudes, and achievement. Proposes a model for the effects of family, school, student…

  8. Physical Activity and Academic Achievement

    Centers for Disease Control (CDC) Podcasts

    2014-12-09

    This podcast highlights the evidence that supports the link between physical activity and improved academic achievement. It also identifies a few actions to support a comprehensive school physical activity program to improve academic achievement.  Created: 12/9/2014 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 12/9/2014.

  9. Healthy Eating and Academic Achievement

    Centers for Disease Control (CDC) Podcasts

    2014-12-09

    This podcast highlights the evidence that supports the link between healthy eating and improved academic achievement. It also identifies a few actions to support a healthy school nutrition environment to improve academic achievement.  Created: 12/9/2014 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 12/9/2014.

  10. Perils of Standardized Achievement Testing

    Science.gov (United States)

    Haladyna, Thomas M.

    2006-01-01

    This article argues that the validity of standardized achievement test-score interpretation and use is problematic; consequently, confidence and trust in such test scores may often be unwarranted. The problem is particularly severe in high-stakes situations. This essay provides a context for understanding standardized achievement testing, then…

  11. Peer relationships and academic achievement

    Directory of Open Access Journals (Sweden)

    Krnjajić Stevan B.

    2002-01-01

    Full Text Available After their childhood, when children begin to establish more intensive social contacts outside family, first of all, in school setting, their behavior i.e. their social, intellectual, moral and emotional development is more strongly affected by their peers. Consequently, the quality of peer relationships considerably affects the process of adaptation and academic achievement and their motivational and emotional attitude towards school respectively. Empirical findings showed that there is bi-directional influence between peer relationships and academic achievement. In other words, the quality of peer relationships affects academic achievement, and conversely, academic achievement affects the quality of peer relationships. For example, socially accepted children exhibiting prosocial, cooperative and responsible forms of behavior in school most frequently have high academic achievement. On the other hand, children rejected by their peers often have lower academic achievement and are a risk group tending to delinquency, absenteeism and drop out of school. Those behavioral and interpersonal forms of competence are frequently more reliable predictors of academic achievement than intellectual abilities are. Considering the fact that various patterns of peer interaction differently exert influence on students' academic behavior, the paper analyzed effects of (a social competence, (b social acceptance/rejection, (c child's friendships and (d prosocial behavior on academic achievement.

  12. Capacity achieving multiwrite WOM codes

    OpenAIRE

    Shpilka, Amir

    2012-01-01

    In this paper we give an explicit construction of a capacity achieving family of binary t-write WOM codes for any number of writes t, that have a polynomial time encoding and decoding algorithms. The block length of our construction is N=(t/\\epsilon)^{O(t/(\\delta\\epsilon))} when \\epsilon is the gap to capacity and encoding and decoding run in time N^{1+\\delta}. This is the first deterministic construction achieving these parameters. Our techniques also apply to larger alphabets.

  13. Strategic Market Entry Factors and Market Share Achievement in Japan

    OpenAIRE

    Adrian B Ryans

    1988-01-01

    In developing entry marketing strategies for new product markets companies might be advised to target product markets where significant market shares are likely to be achieved. The literature on market share change is reviewed to identify situational and marketing strategy factors associated with market share achievement. Certain hypotheses suggested by this and related literatures were then tested using a database of products introduced into the Japanese market. The results of this analysis ...

  14. Dual targeting of peroxisomal proteins

    Directory of Open Access Journals (Sweden)

    Julia eAst

    2013-10-01

    Full Text Available Cellular compartmentalization into organelles serves to separate biological processes within the environment of a single cell. While some metabolic reactions are specific to a single organelle, others occur in more than one cellular compartment. Specific targeting of proteins to compartments inside of eukaryotic cells is mediated by defined sequence motifs. To achieve multiple targeting to different compartments cells use a variety of strategies. Here, we focus on mechanisms leading to dual targeting of peroxisomal proteins. In many instances, isoforms of peroxisomal proteins with distinct intracellular localization are encoded by separate genes. But also single genes can give rise to differentially localized proteins. Different isoforms can be generated by use of alternative transcriptional start sites, by differential splicing or ribosomal read-through of stop codons. In all these cases different peptide variants are produced, of which only one carries a peroxisomal targeting signal. Alternatively, peroxisomal proteins contain additional signals that compete for intracellular targeting. Dual localization of proteins residing in both the cytoplasm and in peroxisomes may also result from use of inefficient targeting signals. The recent observation that some bona fide cytoplasmic enzymes were also found in peroxisomes indicates that dual targeting of proteins to both the cytoplasm and the peroxisome might be more widespread. Although current knowledge of proteins exhibiting only partial peroxisomal targeting is far from being complete, we speculate that the metabolic capacity of peroxisomes might be larger than previously assumed.

  15. Curricular Diversity and Academic Achievement.

    Science.gov (United States)

    Wilson, Reginald

    1991-01-01

    Educational achievement should be intellectually and philosophically divorced from cultural affirmation, which is merely a byproduct of the inclusion of diverse voices in the search for truth. A model based on the relationship between the valuation of oneself by others and by oneself is presented to explain differential effects of schooling on…

  16. Epistemological Beliefs and Academic Achievement

    Science.gov (United States)

    Arslantas, Halis Adnan

    2016-01-01

    This study aimed to identify the relationship between teacher candidates' epistemological beliefs and academic achievement. The participants of the study were 353 teacher candidates studying their fourth year at the Education Faculty. The Epistemological Belief Scale was used which adapted to Turkish through reliability and validity work by…

  17. Achieving world class maintenance status

    Energy Technology Data Exchange (ETDEWEB)

    Tomlingson, P.D. [Paul D. Tomingson Associates (United States)

    2007-08-15

    The article written by a management consultant, discusses the art of successful planning and operation of maintenance in mines considering factors such as benchmaking, key performance indices (KPIs) and frequency of procedures which can help achieve 'world class maintenance'. 1 fig.

  18. Goal Setting to Achieve Results

    Science.gov (United States)

    Newman, Rich

    2012-01-01

    Both districts and individual schools have a very clear set of goals and skills for their students to achieve and master. In fact, except in rare cases, districts and schools develop very detailed goals they wish to pursue. In most cases, unfortunately, only the teachers and staff at a particular school or district-level office are aware of the…

  19. Achieving a sustainable service advantage.

    Science.gov (United States)

    Coyne, K P

    1993-01-01

    Many managers believe that superior service should play little or no role in competitive strategy; they maintain that service innovations are inherently copiable. However, the author states that this view is too narrow. For a company to achieve a lasting service advantage, it must base a new service on a capability gap that competitors cannot or will not copy.

  20. Molecular nuclear imaging for targeting and trafficking

    International Nuclear Information System (INIS)

    Progress of molecular biology, genetic engineering, and polymer chemistry provide various tools to target molecules and cells in vivo. In this paper, recent achievements in targeting receptors for hepatocyte or inflammatory cells and in trafficking bacterial, immune, and stem cells using molecular nuclear imaging techniques are introduced

  1. Establishing seismic design criteria to achieve an acceptable seismic margin

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, R.P. [RPK Structural Mechanics Consulting, Inc., Yorba Linda, CA (United States)

    1997-01-01

    In order to develop a risk based seismic design criteria the following four issues must be addressed: (1) What target annual probability of seismic induced unacceptable performance is acceptable? (2). What minimum seismic margin is acceptable? (3) Given the decisions made under Issues 1 and 2, at what annual frequency of exceedance should the Safe Shutdown Earthquake ground motion be defined? (4) What seismic design criteria should be established to reasonably achieve the seismic margin defined under Issue 2? The first issue is purely a policy decision and is not addressed in this paper. Each of the other three issues are addressed. Issues 2 and 3 are integrally tied together so that a very large number of possible combinations of responses to these two issues can be used to achieve the target goal defined under Issue 1. Section 2 lays out a combined approach to these two issues and presents three potentially attractive combined resolutions of these two issues which reasonably achieves the target goal. The remainder of the paper discusses an approach which can be used to develop seismic design criteria aimed at achieving the desired seismic margin defined in resolution of Issue 2. Suggestions for revising existing seismic design criteria to more consistently achieve the desired seismic margin are presented.

  2. Metacognition, achievement goals, study strategies and academic achievement: pathways to achievement

    NARCIS (Netherlands)

    A. Vrugt; F.J. Oort

    2008-01-01

    The purpose of this research was to develop and test a model of effective selfregulated learning. Based on effort expenditure we discerned effective self-regulators and less effective self-regulators. The model comprised achievement goals (mastery, performance-approach and -avoidance goals), metacog

  3. Migrants and educational achievement gaps

    OpenAIRE

    Entorf, Horst

    2015-01-01

    As global migration flows increase, so do the number of migrant students in host country schools. Yet migrants' achievement scores lag well behind those of their native-born schoolmates. Performance gaps are explained largely by differences in migrant parents' socio-economic background, cultural capital, and language skills. Education policy needs to focus on language teaching, parental involvement, diversity training, and beneficial social interaction between immigrant and native-born popula...

  4. School sport and academic achievement

    OpenAIRE

    Bradley, John L.; Keane, Francis; Crawford, Susan

    2013-01-01

    ABSTRACT BACKGROUND: Physical Education and School Sport (PESS) is an integral part of the school curriculum in Ireland. Historically the Healthy Body, Healthy Mind philosophy has promoted the inclusion of PESS alongside more cognitive school subjects and research suggests that PESS can promote cognitive function and provide educational benefits. However there is little research on how the choice of school sport influences academic achievement. This case study aims to investigate how partic...

  5. Database Research: Achievements and Challenges

    Institute of Scientific and Technical Information of China (English)

    Shan Wang; Xiao-Yong Du; Xiao-Feng Meng; Hong Chen

    2006-01-01

    Database system is the infrastructure of the modern information system. The R&D in the database system moves along by giant steps. This report presents the achievements Renmin University of China (RUC) has made in the past 25 years and at the same time addresses some of the research projects we, RUC, are currently working on. The National Natural Science Foundation of China supports and initiates most of our research projects and these successfully conducted projects have produced fruitful results.

  6. Progress, Wealth, and Mathematics Achievement

    OpenAIRE

    Valero, Paola

    2013-01-01

    I am interested in discussing the historical conditions that make it possible to formulate the idea that the mathematical qualifications of citizens in modern states is connected to the progress and economic development of nations. I interconnect apparently unrelated areas in an attempt to shed light on the grid of intelligibility that makes it possible to fabricate children’s differential achievement in mathematics as a social fact connected to the wealth and development of nations.The emerg...

  7. Media and attention, cognition, and school achievement.

    Science.gov (United States)

    Schmidt, Marie Evans; Vandewater, Elizabeth A

    2008-01-01

    Marie Evans Schmidt and Elizabeth Vandewater review research on links between various types of electronic media and the cognitive skills of school-aged children and adolescents. One central finding of studies to date, they say, is that the content delivered by electronic media is far more influential than the media themselves. Most studies, they point out, find a small negative link between the total hours a child spends viewing TV and that child's academic achievement. But when researchers take into account characteristics of the child, such as IQ or socioeconomic status, this link typically disappears. Content appears to be crucial. Viewing educational TV is linked positively with academic achievement; viewing entertainment TV is linked negatively with achievement. When it comes to particular cognitive skills, say the authors, researchers have found that electronic media, particularly video games, can enhance visual spatial skills, such as visual tracking, mental rotation, and target localization. Gaming may also improve problem-solving skills. Researchers have yet to understand fully the issue of transfer of learning from electronic media. Studies suggest that, under some circumstances, young people are able to transfer what they learn from electronic media to other applications, but analysts are uncertain how such transfer occurs. In response to growing public concern about possible links between electronic media use and attention problems in children and adolescents, say the authors, researchers have found evidence for small positive links between heavy electronic media use and mild attention problems among young people but have found only inconsistent evidence so far for a link between attention deficit hyperactivity disorder and media use. The authors point out that although video games, interactive websites, and multimedia software programs appear to offer a variety of possible benefits for learning, there is as yet little empirical evidence to suggest that

  8. Practically Perfect in Every Way: Can Reframing Perfectionism for High-Achieving Undergraduates Impact Academic Resilience?

    Science.gov (United States)

    Dickinson, Mary J.; Dickinson, David A. G.

    2015-01-01

    This study focuses on a pan-disciplinary scheme that targeted high-achieving undergraduate students. Earlier research from the scheme argued that high achievers have discernibly different learning and personal development support needs. One of the most frequent self-reported challenges within this high-achieving group is perfectionism. This…

  9. Progress, Wealth, and Mathematics Achievement

    DEFF Research Database (Denmark)

    Valero, Paola

    2013-01-01

    light on the grid of intelligibility that makes it possible to fabricate children’s differential achievement in mathematics as a social fact connected to the wealth and development of nations. The emergence of the connection between people’s mathematical qualifications and social progress can be traced......, professional associations argue that the low numbers of people in STEM fields can severely damage the competitiveness of developed nations in international, globalized markets. The narrative that connects progress, economic superiority, and development to citizen’s mathematical competence is made intelligible...

  10. Achieving Universal Access to Broadband

    Directory of Open Access Journals (Sweden)

    Morten FALCH

    2009-01-01

    Full Text Available The paper discusses appropriate policy measures for achieving universal access to broadband services in Europe. Access can be delivered by means of many different technology solutions described in the paper. This means a greater degree of competition and affects the kind of policy measures to be applied. The paper concludes that other policy measure than the classical universal service obligation are in play, and discusses various policy measures taking the Lisbon process as a point of departure. Available policy measures listed in the paper include, universal service obligation, harmonization, demand stimulation, public support for extending the infrastructure, public private partnerships (PPP, and others.

  11. Research achievements and commercial interaction

    International Nuclear Information System (INIS)

    ANSTO, in partnership with Australian and overseas organisations, continues to make significant contributions to selected fields of research and development. Major revenue for ANSTO is generated through sales of radiopharmaceuticals and radioisotopes for medical, industrial, environmental and research purposes and through neutron irradiation services. Further, ANSTO is actively trying to generate maximum value from its knowledge and know-how through protection and exploitation of its intellectual property. Strategic alliances have been developed to further the commercial utilisation of ANSTO know-how in, for example, delivery systems for tumour treatments, commercial waste remediation and applications of plasma implantation. The 2000-2001 financial year saw the establishment of an ANSTO business unit called Sulfide Solutions targeted at better management of environmental issues arising from mining operations. Overall, ANSTO's capacity to generate value from the application of its knowledge and know-how is being increasingly acknowledged, the organisation attaining credibility as an international leader in the application of nuclear science and technology in targeted areas

  12. Infrared Targeting System (IRTS) demonstration

    Science.gov (United States)

    Ohair, Mark A.; Eucker, Shelly S.; Eucker, Brad A.; Lewis, Tim

    1992-02-01

    The objective of the Infrared Targeting System (IRTS) is to successfully demonstrate the mission performance that can be achieved in manned air-to-ground targeting applications utilizing a synergistic combination of state of the art active/passive infrared sensor and automatic target recognizer (ATR) technologies. The IRTS program is centered around a demonstration FLIR/Laser Radar/ATR (FLASHER). The FLASHER consists of a dual field of view (2 x 2 degree and 6 x 6 degree) second generation FLIR pixel mapped to a CO2 laser radar, with a FLIR ATR processor, a laser radar ATR processor, and a sensor fusion ATR processor. Following construction and laboratory testing of the IRTS, the system will be installed on a test aircraft and demonstrated in flight against realistic tactical, strategic, and special operations scenarios.

  13. The Effects of Chronic Achievement Motivation and Achievement Primes on the Activation of Achievement and Fun Goals

    OpenAIRE

    Hart, William; Albarracín, Dolores

    2009-01-01

    This research examined the hypothesis that situational achievement cues can elicit achievement or fun goals depending on chronic differences in achievement motivation. In 4 studies, chronic differences in achievement motivation were measured, and achievement-denoting words were used to influence behavior. The effects of these variables were assessed on self-report inventories, task performance, task resumption following an interruption, and the pursuit of means relevant to achieving or having...

  14. Physical measurements of inertial-fusion targets

    International Nuclear Information System (INIS)

    Measurement of inertial-fusion targets has stimulated the development of many new techniques and instruments. This paper reviews the basis for selected target measurement requirements and the development of optical interferometry, optical scattering, microradiography and scanning electron microscopy as applied to target measurement. We summarize the resolution and speed which have been achieved to date, and describe several systems in which these are traded off to fill specific measurement applications. We point out the extent to which present capabilities meet the requirements for target measurement and the key problems which remain to be solved

  15. On Roald Amundsen's scientific achievements

    Directory of Open Access Journals (Sweden)

    Arnoldus Schytte Blix

    2016-03-01

    Full Text Available This paper describes the significant direct and indirect contributions to science made by the Norwegian polar explorer Roald Amundsen in the period 1897–1924. It documents that his expeditions through the North-west Passage (1903–06 with Gjøa, to the South Pole (1910–12 with Fram and through the North-east Passage (1918–1920 and the Chukchi and East Siberian seas (1921–25 with Maud yielded vast amounts of published scientific material on meteorology, terrestrial magnetism, geology, palaeontology, oceanography, ethnography, zoology and botany, which, though celebrated at the time, have since received scant recognition in more recent assessments of Amundsen's achievements.

  16. National Ignition Facility Target Chamber

    Energy Technology Data Exchange (ETDEWEB)

    Wavrik, R W; Cox, J R; Fleming, P J

    2000-10-05

    was necessary to achieve the overall schedule. Plans had to be developed for the precise location and alignment of laser beam ports. Upon completion of the fabrication of the aluminum target chamber in a temporary structure the 130 ton sphere was moved from the temporary construction enclosure to its final location in the target building. Prior to the installation of a concrete shield and after completion of the welding of the chamber penetrations vacuum leak checking was performed to insure the vacuum integrity of target chamber. The entire spherical chamber external surface supports a 40 cm thick reinforced concrete shield after installation in the target building. The final task is a total survey of the laser ports and the contour machining of spacer plates so that laser devices attached to these ports meet the alignment criteria.

  17. Assessment of Pupils’ Personal Achievements

    Directory of Open Access Journals (Sweden)

    T. A. Strokova

    2015-02-01

    Full Text Available The implementation of the new state educational standards, based on the competence approach, requires some new criteria, procedures and diagnostic tools for estimating pupils’ personal achievements. However, there is a lack of necessary guidelines and recommendations for such objective evaluation and comparative analysis of the effectiveness of educational establishments. The urgent need for unified monitoring instruments induced the author to develop a criteria-diagnostic complex providing the options for evaluating the important personal development aspects – intellectual, value-oriented and moral. The author recommends a self-assessment method for evaluating the intellectual qualities (i.e. self-dependency, critical thinking, logics, flexibility, depth, originality, etc., intellectual competences, and moral traits. The method is based on the tests – «Pupil in his own eyes» and «Pupil in the expert teachers’ eyes». For examining the value orientation, the author takes the classical method by M. Rokich. The approbation of the complex evaluation method was carried out in Tyumen schools and lyceums regarding the last year pupils. The research findings and proposed assessment tools can be used by headmasters and school teachers for monitoring the pupils’ personal growth. 

  18. Assessment of Pupils’ Personal Achievements

    Directory of Open Access Journals (Sweden)

    T. A. Strokova

    2012-01-01

    Full Text Available The implementation of the new state educational standards, based on the competence approach, requires some new criteria, procedures and diagnostic tools for estimating pupils’ personal achievements. However, there is a lack of necessary guidelines and recommendations for such objective evaluation and comparative analysis of the effectiveness of educational establishments. The urgent need for unified monitoring instruments induced the author to develop a criteria-diagnostic complex providing the options for evaluating the important personal development aspects – intellectual, value-oriented and moral. The author recommends a self-assessment method for evaluating the intellectual qualities (i.e. self-dependency, critical thinking, logics, flexibility, depth, originality, etc., intellectual competences, and moral traits. The method is based on the tests – «Pupil in his own eyes» and «Pupil in the expert teachers’ eyes». For examining the value orientation, the author takes the classical method by M. Rokich. The approbation of the complex evaluation method was carried out in Tyumen schools and lyceums regarding the last year pupils. The research findings and proposed assessment tools can be used by headmasters and school teachers for monitoring the pupils’ personal growth. 

  19. Achieving Nuclear Sustainability through Innovation

    International Nuclear Information System (INIS)

    In 2000, the IAEA Member States recognized that concerted and coordinated research and development is needed to drive innovation that ensures that nuclear energy can help meet energy needs sustainably in the 21st century. Following an IAEA General Conference resolution, an international 'think tank' and dialogue forum were established. The resulting organization, the IAEA's International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), helps nuclear technology holders and users coordinate the national and international studies, research and other activities needed to achieve innovations in nuclear reactor designs and fuel cycles. Currently, 38 countries plus the European Commission are participating in the project. This group includes both developing and developed economies that represent more than 75% of the world's population and 85% of its gross domestic product. INPRO undertakes collaborative projects among IAEA Member States, which analyse development scenarios and examine how nuclear energy can support the United Nations' goals for sustainable development in the 21st century. The results of these projects can be applied by IAEA Member States in their national nuclear energy strategies and can lead to international cooperation resulting in beneficial innovations in nuclear energy technology and its deployment. For example, INPRO studies the 'back end' of the fuel cycle, including recycling of spent fuel to increase resource use efficiency and to reduce the waste disposal burdens.

  20. CEREBRAL PALSY AND MUSIC ACHIEVEMENT

    Directory of Open Access Journals (Sweden)

    Miodrag L. STOSHLJEVIKJ

    2008-12-01

    Full Text Available Pupils with cerebral palsy attend elementary education accordind to a regular and special teaching plan and program. Regular school curriculum was reformed in 1992, while special plan and program has not been changed and adapted according to pupil’s needs and capacities. Music is one of the best means of expressing oneself and plays a very important role in the development of every child, the child with cerebral palsy in particular.In order to test the possibility of pupils with cerebral palsy, with and without mental retardation, to apprehend the actual program content, we have conducted research on musical achievement of children with cerebral palsy. During 2007 a research was carried out, on the sample of 27 pupils with cerebral palsy and mild mental retardation who attended classes in the school “Miodrag Matikj”, and a sample of16 students with cerebral palsy without mental retardation who attended the school “Dr. Dragan Hercog” in Belgrade.Results of the research, as well as analysis of music curriculum content, indicated that the capacities of students with cerebral palsy to carry out the curriculum tasks require special approach and methodology. Therefore, we introduced some proposals to overcome the difficulties in fulfilling music curriculum demands of those pupils. We made special emphasis on the use of computer based Assistive technology which facilitates the whole process to a large extent.

  1. Challenges in achieving food security in India.

    Science.gov (United States)

    Upadhyay, R Prakash; Palanivel, C

    2011-12-01

    First Millennium Development Goal states the target of "Halving hunger by 2015". Sadly, the recent statistics for India present a very gloomy picture. India currently has the largest number of undernourished people in the world and this is in spite of the fact that it has made substantial progress in health determinants over the past decades and ranks second worldwide in farm output. The causes of existing food insecurity can be better viewed under three concepts namely the: 'traditional concept' which includes factors such as unavailability of food and poor purchasing capacity; 'socio-demographic concept' which includes illiteracy, unemployment, overcrowding, poor environmental conditions and gender bias; 'politico-developmental concept' comprising of factors such as lack of intersectoral coordination and political will, poorly monitored nutritional programmes and inadequate public food distribution system. If the Millennium Development Goal is to be achieved by 2015, efforts to improve food and nutrition security have to increase considerably. Priority has to be assigned to agriculture and rural development along with promoting women empowerment, ensuring sustainable employment and improving environmental conditions (water, sanitation and hygiene). As the problem is multi-factorial, so the solution needs to be multi-sectoral.

  2. Competitive Advantage Achievement through Innovation and Knowledge

    Directory of Open Access Journals (Sweden)

    Urbancova Hana

    2013-03-01

    Full Text Available In today’s highly competitive environment the goal of each organisation is to defeat competition and win new customers. Individuals who are holders of knowledge represent a tool for the generation of innovations. Thanks to their personal creativity, their knowledge, skills and abilities it is possible to generate new innovative ideas that will help organisations to achieve a competitiveadvantage. The aim of the article is to present the findings of a survey targeted at innovations and to identify knowledge as an important element in the process of innovations. Primary data were obtained through a questionnaire survey carried out in organisations in the Czech Republic and evaluated using the tools of descriptive statistics and also the methods of comparison, induction, deduction and synthesis were applied. One of the conclusions of the article is that organisations find it important to innovate and support an innovative culture. Knowledge too is very significant in the innovation process since it represents not only important input, but also output of the transformation process.

  3. Challenges in Achieving Food Security in India

    Directory of Open Access Journals (Sweden)

    R Prakash Upadhyay

    2011-12-01

    Full Text Available First Millennium Development Goal states the target of "Halving hunger by 2015". Sadly, the recent statistics for India pre­sent a very gloomy picture. India currently has the largest number of undernourished people in the world and this is in spite of the fact that it has made substantial progress in health determinants over the past decades and ranks second world­wide in farm output. The causes of existing food insecurity can be better viewed under three concepts namely the: ‘tradi­tional con­cept' which includes factors such as unavailability of food and poor purchasing capacity; ‘socio-de­mographic concept' which includes illiteracy, unemployment, overcrowding, poor environmental conditions and gender bias; ‘politico-devel­opmental concept' comprising of factors such as lack of intersectoral coordination and political will, poorly monitored nu­tritional programmes and inadequate public food distribution system. If the Millennium Development Goal is to be achieved by 2015, efforts to improve food and nutrition security have to increase considerably. Priority has to be assigned to agricul­ture and rural development along with promoting women empowerment, ensuring sustainable employ­ment and im­proving environmental conditions (water, sanitation and hygiene. As the problem is multi-factorial, so the solu­tion needs to be multi-sectoral.

  4. Achieving Sustainable Value Planning For Malaysian Public Projects

    OpenAIRE

    Muhammad Faudzi; Mahbub Rohana; Nawawi Abdul Hadi; Abidin Nazirah Zainul

    2016-01-01

    Sustainability is the central development issue in the modern economy. Through sustainable development, quality of life can be improved or maintained over time. Since Malaysia is targeting to become a high-income nation by the year 2020, financial investment in public projects should be planned comprehensively so that it will generate immediate and long-term benefits to the country and the people. Within the currently tight financial environment, achieving value for money in public spending i...

  5. Achieving monospermy or preventing polyspermy?

    Directory of Open Access Journals (Sweden)

    Dale B

    2016-06-01

    Full Text Available Brian Dale Centre for Assisted Fertilization, Naples, Italy Abstract: Images of sea urchin oocytes with hundreds of spermatozoa attached to their surface have fascinated scientists for over a century and led to the idea that oocytes have evolved mechanisms to allow the penetration of one spermatozoon while repelling supernumerary spermatozoa. Popular texts have extrapolated this concept, to the mammals and amphibians, and in many cases to include all the Phyla. Here, it is argued that laboratory experiments, using sea urchin oocytes deprived of their extracellular coats and inseminated at high densities, are artifactual and that the experiments leading to the idea of a fast block to polyspermy are flawed. Under natural conditions, the number of spermatozoa at the site of fertilization is extremely low, compared with the numbers generated. The sperm:oocyte ratio is regulated first by dilution in externally fertilizing species and the female reproductive tract in those with internal fertilization, followed by a bottleneck created by the oocytes extracellular coats. In order to progress to the oocyte plasma membrane, the fertilizing spermatozoon must encounter and respond to a correct sequence of signals from the oocytes extracellular coats. Those that do not, are halted in their progression by defective signaling and fall to the wayside. Final success and entry is finely tuned by the spermatozoon anchoring to an actin-rich predetermined site on the plasma membrane. In this review, the variation in the form, function, and number of gametes produced across the animal kingdom and the many ways in which sperm–oocyte interactions are regulated to reduce numbers are discussed. Since in nature, final sperm:oocyte ratios approach unity it would appear that selective pressures have favored the achievement of monospermy, rather than the evolution of polyspermy preventing mechanisms. Keywords: monospermy, natural conditions, polyspermy, laboratory

  6. Target Visualization at the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Potter, Daniel Abraham [Univ. of California, Davis, CA (United States)

    2011-01-01

    As the National Ignition Facility continues its campaign to achieve ignition, new methods and tools will be required to measure the quality of the targets used to achieve this goal. Techniques have been developed to measure target surface features using a phase-shifting diffraction interferometer and Leica Microsystems confocal microscope. Using these techniques we are able to produce a detailed view of the shell surface, which in turn allows us to refine target manufacturing and cleaning processes. However, the volume of data produced limits the methods by which this data can be effectively viewed by a user. This paper introduces an image-based visualization system for data exploration of target shells at the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory. It aims to combine multiple image sets into a single visualization to provide a method of navigating the data in ways that are not possible with existing tools.

  7. Magnetic targeted drug delivery

    Directory of Open Access Journals (Sweden)

    Timothy Wiedmann

    2009-10-01

    Full Text Available Lung cancer is the most common cause of death from cancer in both men and women. Treatment by intravenous or oral administration of chemotherapy agents results in serious and often treatment-limiting side effects. Delivery of drugs directly to the lung by inhalation of an aerosol holds the promise of achieving a higher concentration in the lung with lower blood levels. To further enhance the selective lung deposition, it may be possible to target deposition by using external magnetic fields to direct the delivery of drug coupled to magnetic particles. Moreover, alternating magnetic fields can be used to induce particle heating, which in turn controls the drug release rate with the appropriate thermal sensitive material.With this goal, superparamagetic nanoparticles (SPNP were prepared and characterized, and enhanced magnetic deposition was demonstrated in vitro and in vivo. SPNPs were also incorporated into a lipid-based/SPNP aerosol formulation, and drug release was shown to be controlled by thermal activation. Because of the inherent imaging potential of SPNPs, this use of nanotechnology offers the possibility of coupling the diagnosis of lung cancer to drug release, which perhaps will ultimately provide the “magic bullet” that Paul Ehrlich originally sought.

  8. Electrically charged targets

    Science.gov (United States)

    Goodman, Ronald K.; Hunt, Angus L.

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  9. Achievements and perspectives of ERAWAST

    Directory of Open Access Journals (Sweden)

    Dressler R.

    2010-10-01

    Full Text Available The ERAWAST initiative (Exotic Radionuclides from Accelerator Waste for Science and Technology was started at PSI in 2006 and is aimed to acquire resources from the PSI accelerator facilities for the preparation of rare long-lived radionuclides for several scientific purposes [1]. One of the application fields where such radionuclides like 60Fe, 53Mn, 44Ti, 26Al, 7/10Be are urgently needed is nuclear astrophysics. First laboratory-scale separations have been carried out, with the result that two samples of around 1016 atoms of 60Fe each could be provided for experiments [2]. A re-determination of the half-life of 60Fe was performed with the first one [3], and the neutron capture cross section of 60Fe at stellar energies was measured for the first time [4] using the second one. These successes encouraged us to put more efforts into the development of remote- controlled separation systems in order to gain higher amounts and the exploitation of new sources of the desired isotopes. These works are currently ongoing and for the first time, separation of about 5 GBq 7Be from the cooling water of the Swiss Spallation Neutron Source (SINQ was succeeded. Moreover, about 50  g of 10Be are now available after its separation from graphite samples of the target E station at PSI [5]. Considerable amounts of 60Fe, 53Mn, 26Al and others from an irradiated copper beam dump can be expected in the near future. In addition, a scientific program was originated to determine half-lives and neutron capture cross-section of astrophysical interesting radionuclides. In a first step a confirmation of the new measured 60Fe half-life in two independent experiments was started. First studies aimed to re-measure the half-life of 10Be are currently ongoing. Experiments to determine the neutron capture cross-section of 53Mn using cold and ultra-cold neutrons as well as its half-life at PSI are planned.

  10. The History of Target-Controlled Infusion.

    Science.gov (United States)

    Struys, Michel M R F; De Smet, Tom; Glen, John Iain B; Vereecke, Hugo E M; Absalom, Anthony R; Schnider, Thomas W

    2016-01-01

    Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.

  11. Target injection methods for inertial fusion energy

    Energy Technology Data Exchange (ETDEWEB)

    Petzoldt, R.W.; Moir, R.W.

    1994-06-01

    We have studied four methods to inject IFE targets: the gas gun, electrostatic accelerator, induction accelerator, and rail gun. We recommend a gas gun for indirect drive targets because they can support a gas pressure load on one end and can slide along the gun barrel without damage. With the gas gun, the amount of gas required for each target (about 10 to 100 mg) is acceptable; for other types of targets, a sabot would be necessary. A cam and poppet valve arrangement is recommended for gas flow control. An electrostatic accelerator is attractive for use with lightweight spherical direct drive targets. Since there is no physical contact between the target and the injector, there will be no wear of either component during the injection process. An induction accelerator has an advantage of no electrical contact between the target and the injector. Physical contact is not even necessary, so the wear should be minimal. It requires a cylindrical conductive target sleeve which is a substantial added mass. A rail gun is a simpler device than an electrostatic accelerator or induction accelerator. It requires electrical contact between the target and the rails and may have a significant wear rate. The wear in a vacuum could be reduced by use of a solid lubricant such as MoS{sub 2}. The total required accuracy of target injection, tracking and beam pointing of {plus_minus}0.4 mm appears achievable but will require development and experimental verification.

  12. An Analysis of High School Mathematics Achievement and English Language Arts Achievement as Predictors of Science Achievement

    Science.gov (United States)

    Edwards, Anthony C.

    2012-01-01

    Science assessments require students to read and comprehend questions and to solve mathematical problems. The purpose of this study is to determine whether the following variables can be used to predict science achievement: English language arts achievement, mathematics achievement, socioeconomic status (SES), limited English proficiency (LEP)…

  13. Direct-illumination spherical-target experiments

    International Nuclear Information System (INIS)

    A set of spherical target experiments was designed to evaluate the effectiveness of three techniques for achieving higher convergence implosions. They are (1) cryogenically frozen fuel layers, (2) submicron wavelength laser light, and (3) temporally tailored pulse shapes. A second set of experiments provides information about energy transport by thermal and suprathermal electrons and uses multilayered targets as an integral component of the diagnostics. These results, in conjunction with existing laser-target coupling data, provide a more comprehensive test of our understanding of laser plasma interaction, energy transport, and hydrodynamic response of small scale spherical laser fusion experiments

  14. Arts Achieve, Impacting Student Success in the Arts: Preliminary Findings after One Year of Implementation

    Science.gov (United States)

    Mastrorilli, Tara M.; Harnett, Susanne; Zhu, Jing

    2014-01-01

    The "Arts Achieve: Impacting Student Success in the Arts" project involves a partnership between the New York City Department of Education (NYCDOE) and five of the city's premier arts organizations. "Arts Achieve" provides intensive and targeted professional development to arts teachers over a three-year period. The goal…

  15. Neural fuzzy inference network approach to maneuvering target tracking

    Institute of Scientific and Technical Information of China (English)

    韩红; 刘允才; 韩崇昭; 朱洪艳; 文戎

    2004-01-01

    In target tracking study, the fast target maneuver detecting and highly accurate tracking are very important.And it is difficult to be solved. For the radar/infrared image fused tracking system, a extend Kalman filter combines with a neural fuzzy inference network to be used in maneuvering target tracking. The features related to the target maneuver are extracted from radar, infrared measurements and outputs of tracking filter, and are sent into the neural fuzzy inference network as inputs firstly, and then the target's maneuver inputs are estimated, so that, the accurate tracking is achieved. The simulation results indicate that the new method is valuable for maneuvering target tracking.

  16. Exploiting novel molecular targets in gastrointestinal cancers

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Novel molecular targets are being discovered as we learn more about the aberrant processes underlying various cancers. Efforts to translate this knowledge are starting to impact on the care of patients with gastrointestinal cancers. The epidermal growth factor receptor (EGFR) pathway and angiogenesis have been targeted successfully in colorectal cancer with cetuximab, panitunumab and bevacizumab. Similarly, EGFR-targeting with erlotinib yielded significant survival benefit in pancreatic cancer when combined with gemcitabine. The multi-targeting approach with sorafenib has made it the first agent to achieve significant survival benefit in hepatocellular carcinoma. Efforts to exploit the dysregulated Akt/mTOR pathway in GI cancer therapy are ongoing. These molecular targets can be disrupted by various approaches, including the use of monoclonal antibody to intercept extracellular ligands and disrupt receptor-ligand binding, and small molecule inhibitors that interrupt the activation of intracellular kinases.

  17. Fluid mechanics aspects of magnetic drug targeting.

    Science.gov (United States)

    Odenbach, Stefan

    2015-10-01

    Experiments and numerical simulations using a flow phantom for magnetic drug targeting have been undertaken. The flow phantom is a half y-branched tube configuration where the main tube represents an artery from which a tumour-supplying artery, which is simulated by the side branch of the flow phantom, branches off. In the experiments a quantification of the amount of magnetic particles targeted towards the branch by a magnetic field applied via a permanent magnet is achieved by impedance measurement using sensor coils. Measuring the targeting efficiency, i.e. the relative amount of particles targeted to the side branch, for different field configurations one obtains targeting maps which combine the targeting efficiency with the magnetic force densities in characteristic points in the flow phantom. It could be shown that targeting efficiency depends strongly on the magnetic field configuration. A corresponding numerical model has been set up, which allows the simulation of targeting efficiency for variable field configuration. With this simulation good agreement of targeting efficiency with experimental data has been found. Thus, the basis has been laid for future calculations of optimal field configurations in clinical applications of magnetic drug targeting. Moreover, the numerical model allows the variation of additional parameters of the drug targeting process and thus an estimation of the influence, e.g. of the fluid properties on the targeting efficiency. Corresponding calculations have shown that the non-Newtonian behaviour of the fluid will significantly influence the targeting process, an aspect which has to be taken into account, especially recalling the fact that the viscosity of magnetic suspensions depends strongly on the magnetic field strength and the mechanical load. PMID:26415215

  18. Determinants of Student Achievement in Turkey

    OpenAIRE

    Gokce Uysal; M. Alper Dincer

    2009-01-01

    Recent achievement test results show that Turkish students have been performing poorly compared to students from other countries. Using data from the PISA 2006 survey, we aim to measure the determinants of student achievement in Turkey. We find that the program type the student is enrolled in affects student achievement significantly. However, this effect may partially be biased by past academic achievement. In line with the previous literature, our results also indicate that school resources...

  19. IMPORTANCE OF ACHIEVEMENT MOTIVATION IN SPORTS PERFORMANCE

    OpenAIRE

    Jyoti A Upadhye; N Chandrappa

    2014-01-01

    The present article defines the psychological construct of Achievement motivation and its influence on Sportsman to achieve their goals and to improve their performance level. Achievement Motivation is a mindset that leads people to set for themselves realistic but challenging goals. In Achievement Motivation can calculate mathematically by taking a person's desire to succeed and subtracting their fear of failure. When a student is motivated, he is inspired to pursue greater a...

  20. TARGET COSTING FUNCTIONS

    OpenAIRE

    Dimi OFILEANU

    2015-01-01

    This article aims to highlight the concept of Target Costing. Based on the characteristics of Target Costing, identified in specialized literature, the article presents its main advantages and disadvantages. Also, a comparison is being made between Target Cost and Traditional Cost (in its traditional form, the cost represents an independent variable on the basis of which the sell price is established; and in the Target Cost form the cost represents a dependent variable which is determined on ...

  1. Multilayer polymer microspot targets

    International Nuclear Information System (INIS)

    Last year the authors reported on the development of a seeded microspot x-ray diagnostic target. This target consisted of a 300-μm-diam, 2-μm-thick disk of silicon or sulfur-seeded hydrocarbon polymer nested tightly in a hole in a 2-μm-thick film of pure hydrocarbon polymer. This year they extended our work on the microspot target, fully encapsulating the microspot in what they call the multilayer polymer microspot target

  2. The Targeting of Advertising

    OpenAIRE

    Ganesh Iyer; David Soberman; J. Miguel Villas-Boas

    2005-01-01

    An important question that firms face in advertising is developing effective media strategy. Major improvements in the quality of consumer information and the growth of targeted media vehicles allow firms to precisely target advertising to consumer segments within a market. This paper examines advertising strategy when competing firms can target advertising to different groups of consumers within a market. With targeted advertising, we find that firms advertise more to consumers who have a st...

  3. Target Price Accuracy

    OpenAIRE

    Alexander G. Kerl

    2011-01-01

    This study analyzes the accuracy of forecasted target prices within analysts’ reports. We compute a measure for target price forecast accuracy that evaluates the ability of analysts to exactly forecast the ex-ante (unknown) 12-month stock price. Furthermore, we determine factors that explain this accuracy. Target price accuracy is negatively related to analyst-specific optimism and stock-specific risk (measured by volatility and price-to-book ratio). However, target price accuracy is positive...

  4. Randomized trial of achieving healthy lifestyles in psychiatric rehabilitation: the ACHIEVE trial

    Directory of Open Access Journals (Sweden)

    Guallar Eliseo

    2010-12-01

    Full Text Available Abstract Background Overweight and obesity are highly prevalent among persons with serious mental illness. These conditions likely contribute to premature cardiovascular disease and a 20 to 30 percent shortened life expectancy in this vulnerable population. Persons with serious mental illness need effective, appropriately tailored behavioral interventions to achieve and maintain weight loss. Psychiatric rehabilitation day programs provide logical intervention settings because mental health consumers often attend regularly and exercise can take place on-site. This paper describes the Randomized Trial of Achieving Healthy Lifestyles in Psychiatric Rehabilitation (ACHIEVE. The goal of the study is to determine the effectiveness of a behavioral weight loss intervention among persons with serious mental illness that attend psychiatric rehabilitation programs. Participants randomized to the intervention arm of the study are hypothesized to have greater weight loss than the control group. Methods/Design A targeted 320 men and women with serious mental illness and overweight or obesity (body mass index ≥ 25.0 kg/m2 will be recruited from 10 psychiatric rehabilitation programs across Maryland. The core design is a randomized, two-arm, parallel, multi-site clinical trial to compare the effectiveness of an 18-month behavioral weight loss intervention to usual care. Active intervention participants receive weight management sessions and physical activity classes on-site led by study interventionists. The intervention incorporates cognitive adaptations for persons with serious mental illness attending psychiatric rehabilitation programs. The initial intensive intervention period is six months, followed by a twelve-month maintenance period in which trained rehabilitation program staff assume responsibility for delivering parts of the intervention. Primary outcomes are weight loss at six and 18 months. Discussion Evidence-based approaches to the high burden

  5. The Intersection of Culture and Achievement Motivation

    Science.gov (United States)

    Trumbull, Elise; Rothstein-Fisch, Carrie

    2011-01-01

    Achievement motivation is something that all members of the school community want to support in students, however few may recognize that it is influenced by culture. The very meaning of "achievement" is culturally variable, and the motives that students have for achieving may be quite different, depending upon their cultural background. The…

  6. Predicting Academic Achievement with Cognitive Ability

    Science.gov (United States)

    Rohde, Treena Eileen; Thompson, Lee Anne

    2007-01-01

    The purpose of the present study is to explain variation in academic achievement with general cognitive ability and specific cognitive abilities. Grade point average, Wide Range Achievement Test III scores, and SAT scores represented academic achievement. The specific cognitive abilities of interest were: working memory, processing speed, and…

  7. The Influence of Poverty on Achievement

    Science.gov (United States)

    Tienken, Christopher H.

    2012-01-01

    Without a doubt, poverty has a negative influence on student achievement, especially when achievement is measured by state-mandated standardized tests. However, some bureaucrats, such as state commissioners of education and even state governors, continue to downplay the influence of poverty on student achievement. New Jersey's Governor Chris…

  8. Changes in Achievement Motivation among University Freshmen

    Science.gov (United States)

    Dresel, Markus; Grassinger, Robert

    2013-01-01

    Changes in achievement motivation over the first semester of university studies were examined with N = 229 freshmen, who were surveyed twice in the present study. Students' academic self-concepts, achievement goals, and subjective values were chosen as theoretically central components of achievement motivation. The results indicated significant…

  9. 28 CFR 545.28 - Achievement awards.

    Science.gov (United States)

    2010-07-01

    ... COMPENSATION Inmate Work and Performance Pay Program § 545.28 Achievement awards. (a) With prior approval of... achievement award from performance pay funds. (b) With prior approval of the Psychology Services Department... also be granted an achievement award from performance pay funds....

  10. An actionable climate target

    Science.gov (United States)

    Geden, Oliver

    2016-05-01

    The Paris Agreement introduced three mitigation targets. In the future, the main focus should not be on temperature targets such as 2 or 1.5 °C, but on the target with the greatest potential to effectively guide policy: net zero emissions.

  11. High Power Cryogenic Targets

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  12. Accelerating the Achievement of MDGs through CSR: An Actual Discussion in Indonesia and Germany

    OpenAIRE

    M. Fani Cahyandito

    2011-01-01

    The government of Indonesian is committed to achieve the Millennium Development Goals (MDGs). Deadline for the achievement of MDGs in 2015 is in sight. Many of the targets had been reached by Indonesia, but there are also some homeworks remain to be done to meet all the MDGs. Aspect of limited government funding is seen to be an obstacle in achieving this. Therefore it is necessary to build synergy to implement development programs between the government and the private sector (private compan...

  13. Target studies for surface muon production

    Science.gov (United States)

    Berg, F.; Desorgher, L.; Fuchs, A.; Hajdas, W.; Hodge, Z.; Kettle, P.-R.; Knecht, A.; Lüscher, R.; Papa, A.; Rutar, G.; Wohlmuther, M.

    2016-02-01

    Meson factories are powerful drivers of diverse physics programs. With beam powers already in the MW-regime attention has to be turned to target and beam line design to further significantly increase surface muon rates available for experiments. For this reason we have explored the possibility of using a neutron spallation target as a source of surface muons by performing detailed Geant4 simulations with pion production cross sections based on a parametrization of existing data. While the spallation target outperforms standard targets in the backward direction by more than a factor 7 it is not more efficient than standard targets viewed under 90°. Not surprisingly, the geometry of the target plays a large role in the generation of surface muons. Through careful optimization, a gain in surface muon rate of between 30% and 60% over the standard "box-like" target used at the Paul Scherrer Institute could be achieved by employing a rotated slab target. An additional 10% gain could also be possible by utilizing novel target materials such as, e.g., boron carbide.

  14. Effects of Gender, Mathematics Anxiety and Achievement Motivation on College Students’ Achievement in Mathematics

    OpenAIRE

    Ajogbeje Oke James; Borisade Fidelis Tunde; Aladesaye Charles Ademuyiwa; Ayodele Oludolapo Bolanle

    2013-01-01

    The urge to excel or perform maximally in mathematics varies from individual to individual because achievement motivation is often developed or learnt during socialization and learning experiences. The study examined the relationship between College of Education students’ achievement motivation and mathematics achievement, correlation coefficient between mathematics anxiety and college students’ achievement motivation as well as mathematics anxiety and mathematics achievement. The sample, 268...

  15. Tabu search for target-radar assignment

    DEFF Research Database (Denmark)

    Hindsberger, Magnus; Vidal, Rene Victor Valqui

    2000-01-01

    In the paper the problem of assigning air-defense illumination radars to enemy targets is presented. A tabu search metaheuristic solution is described and the results achieved are compared to those of other heuristic approaches, implementation and experimental aspects are discussed. It is argued ...

  16. Complete fabrication of target experimental chamber and implement initial target diagnostics to be used for the first target experiments in NDCX-1

    Energy Technology Data Exchange (ETDEWEB)

    Bieniosek, F.M.; Bieniosek, F.M.; Dickinson, M.R.; Henestroza, E.; Katayanagi, T.; Jung, J.Y.; Lee, C.W.; Leitner, M.; Ni, P.; Roy, P.; Seidl, P.; Waldron, W.; Welch, D.

    2008-06-09

    The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL) has completed the fabrication of a new experimental target chamber facility for future Warm Dense Matter (WDM) experiments, and implemented initial target diagnostics to be used for the first target experiments in NDCX-1. The target chamber has been installed on the NDCX-I beamline. This achievement provides to the HIFS-VNL unique and state-of-the-art experimental capabilities in preparation for the planned target heating experiments using intense heavy ion beams.

  17. Targeted cancer therapies

    Institute of Scientific and Technical Information of China (English)

    Li Yan; Neal Rosen; Carlos Arteaga

    2011-01-01

    With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed. These targeted cancer therapies are being actively tested in clinical trials with mixed successes. This editorial provides an overview on successful targeted cancer drugs on the market and those drugs that are in late clinical development stages. Importantly, the article lays out main challenges in developing molecular targeted therapies and potential path forward to overcome these challenges, as well as opportunities for China in this new era of targeted agents. The editorial serves as an introduction to the Targeted Cancer Therapies serias that will review in depth of major pathways and drugs targeting these pathways to be published in the coming issues of the Chinese Journal of Cancer.

  18. Polarized targets and beams

    International Nuclear Information System (INIS)

    First the experimental situation of the single-pion photoproduction and the photodisintegration of the deuteron is briefly discussed. Then a description of the Bonn polarization facilities is given. The point of main effort is put on the polarized target which plays a vital role in the program. A facility for photon induced double polarization experiments at ELSA will be presented in section 4. Properties of a tensor polarized deuteron target are discussed in section 5. The development in the field of polarized targets, especially on new target materials, enables a new generation of polarized target experiments with (polarized) electrons. Some comments on the use of a polarized target in combination with electron beams will be discussed in section 6. Electron deuteron scattering from a tensor polarized deuteron target is considered and compared with other experimental possibilities. (orig./HSI)

  19. Academic Attitudes of High Achieving and Low Achieving Academically Able Black Male Adolescents.

    Science.gov (United States)

    Trotter, John Rhodes

    1981-01-01

    In order to identify the relationships between the attitudes and perceptions of peer pressure and the academic achievement of academically able male adolescents, this study compares the school attitudes of high achieving and low achieving Black male youth. (EF)

  20. Targeted therapies in hepatocellular carcinoma.

    Science.gov (United States)

    Bronte, F; Bronte, G; Cusenza, S; Fiorentino, E; Rolfo, C; Cicero, G; Bronte, E; Di Marco, V; Firenze, A; Angarano, G; Fontana, T; Russo, A

    2014-01-01

    The onset of hepatocellular carcinoma (HCC) is related to the development of non-neoplastic liver disease, such as viral infections and cirrhosis. Even though patients with chronic liver diseases undergo clinical surveillance for early diagnosis of HCC, this cancer is often diagnosed in advanced stage. In this case locoregional treatment is not possible and systemic therapies are the best way to control it. Until now sorafenib, a Raf and multi-kinase inhibitor has been the best, choice to treat HCC systemically. It showed a survival benefit in multicenter phase III trials. However the proper patient setting to treat is not well defined, since the results in Child-Pugh B patients are conflicting. To date various new target drugs are under developed and other biological treatments normally indicated in other malignancies are under investigation also for HCC. These strategies aim to target the different biological pathways implicated in HCC development and progression. The target drugs studied in HCC include anti-VEGF and anti-EGFR monoclonal antibodies, tyrosine kinase inhibitors and mTOR inhibitors. The most important challenge is represented by the best integration of these drugs with standard treatments to achieve improvement in overall survival and quality of life.

  1. Rotating target wheel for the FMA

    Energy Technology Data Exchange (ETDEWEB)

    Back, B.B.; Davids, C.N.; Falout, J. [and others

    1995-08-01

    In anticipation of high intensity beams that will be available from the PII-ECR source injector to ATLAS, a new rotating target wheel was developed for the sliding seal chamber at the FMA. The wheel is 9 inch in diameter and contains up to ten targets. The rotation of the wheel is achieved by a DC motor, a ferrofluidic feedthrough, and a gear mechanism that allows both target rotation and changing the target angle relative to the beam. The nominal rotation speed is 1000 RPM, although higher speeds can be achieved if necessary. The assembly is equipped with an absolute encoder which is read out via a newly developed CAMAC module. This module provides the following main functions: (1) a TTL signal to be used for sweeping the beam when a target frame is about to pass through the beam, (2) a read-out of the target position that can be included in the data event structure, (3) programmable set points for the beam-off signal. The system is presently being tested and will be used in experiments scheduled for March 1995.

  2. Target Studies for Surface Muon Production

    CERN Document Server

    Berg, F; Fuchs, A; Hajdas, W; Hodge, Z; Kettle, P -R; Knecht, A; Lüscher, R; Papa, A; Rutar, G; Wohlmuther, M

    2015-01-01

    Meson factories are powerful drivers of diverse physics programmes. With beam powers already in the MW-regime attention has to be turned to target and beam line design to further significantly increase surface muon rates available for experiments. For this reason we have explored the possibility of using a neutron spallation target as a source of surface muons by performing detailed Geant4 simulations with pion production cross sections based on a parametrization of existing data. While the spallation target outperforms standard targets in the backward direction by more than a factor 7 it is not more efficient than standard targets viewed under 90{\\deg}. Not surprisingly, the geometry of the target plays a large role in the generation of surface muons. Through careful optimization, a gain in surface muon rate of between 30 - 60% over the standard "box-like" target used at the Paul Scherrer Institute could be achieved by employing a rotated slab target. An additional 10% gain could also be possible by utilizin...

  3. Liquid hydrogen target cooled by circulating helium

    International Nuclear Information System (INIS)

    Structure and characteristics of a liquid hydrogen target, where hydrogen is liquefied with liquid helium flow using evaporation heat of liquid helium and vapour cold, are described. Good thermal insulation of liquid helium supply line permits to remove out of the target the most volumetric and heavy component - helium tank - and to supply liquid helium along spreaded pipeline from the Dewar helium flask. It results in considerable reduction of dimensions and weight, the structure simplification and work facilitation with the target. The target having a working volume of 400 mm length and 60 mm diameter was tested. Vacuum casing of the working volume was made of foam plastic, heat flow to the working volume is equal to 1.5 W. Achieving mode of operation including structure cooling and hydrogen liquefaction took approximately 3 h, liquid helium flow rate for liquefaction of 1 l hydrogen is 2.7 l. Liquid helium flow rate in the mode of operation was equal to 0.7 l/h, i.e. target operation period without adding liquid helium to the Dewar flask is 4-5 days. The target described is notable for simplicity in fabrication, reliability in operation and is very suitable for using in experiment as compared to existing targets with hydrogen liquefaction with liquid helium. Unit structure of the target enables to easily change its configuration relative to problems of concrete physical experiment

  4. Antecedents of students' achievement in statistics

    Science.gov (United States)

    Awaludin, Izyan Syazana; Razak, Ruzanna Ab; Harris, Hezlin; Selamat, Zarehan

    2015-02-01

    The applications of statistics in most fields have been vast. Many degree programmes at local universities require students to enroll in at least one statistics course. The standard of these courses varies across different degree programmes. This is because of students' diverse academic backgrounds in which some comes far from the field of statistics. The high failure rate in statistics courses for non-science stream students had been concerning every year. The purpose of this research is to investigate the antecedents of students' achievement in statistics. A total of 272 students participated in the survey. Multiple linear regression was applied to examine the relationship between the factors and achievement. We found that statistics anxiety was a significant predictor of students' achievement. We also found that students' age has significant effect to achievement. Older students are more likely to achieve lowers scores in statistics. Student's level of study also has a significant impact on their achievement in statistics.

  5. Three brief assessments of math achievement.

    Science.gov (United States)

    Steiner, Eric T; Ashcraft, Mark H

    2012-12-01

    Because of wide disparities in college students' math knowledge-that is, their math achievement-studies of cognitive processing in math tasks also need to assess their individual level of math achievement. For many research settings, however, using existing math achievement tests is either too costly or too time consuming. To solve this dilemma, we present three brief tests of math achievement here, two drawn from the Wide Range Achievement Test and one composed of noncopyrighted items. All three correlated substantially with the full achievement test and with math anxiety, our original focus, and all show acceptable to excellent reliability. When lengthy testing is not feasible, one of these brief tests can be substituted.

  6. ACHIEVING "DECENT WORK" IN SOUTH AFRICA?

    Directory of Open Access Journals (Sweden)

    Tamara Cohen

    2012-08-01

    Full Text Available The fundamental goal of the International Labour Organisation is the achievement of decent and productive work for both women and men in conditions of freedom, equity, security and human dignity. The South African government has pledged its commitment to the attainment of decent work and sustainable livelihoods for all workers and has undertaken to mainstream decent work imperatives into national development strategies. The four strategic objectives of decent work as identified by the ILO are: i the promotion of standards and rights at work, to ensure that worker's constitutionally protected rights to dignity, equality and fair labour practices, amongst others, are safeguarded by appropriate legal frameworks; (ii the promotion of employment creation and income opportunities, with the goal being not just the creation of jobs but the creation of jobs of acceptable quality; (iii the provision and improvement of social protection and social security, which are regarded as fundamental to the alleviation of poverty, inequality and the burden of care responsibilities; and (iv the promotion of social dialogue and tripartism. This article considers the progress made towards the attainment of these decent work objectives in South Africa, using five statistical indicators to measure such progress namely: (i employment opportunities; (ii adequate earnings and productive work; (iii stability and security of work; (iv social protection; and (v social dialogue and workplace relations. It concludes that high levels of unemployment and a weakened economy in South Africa have given rise to a growing informal sector and an increase in unacceptable working conditions and exploitation. The rights of workers in the formal sector have not filtered down to those in the informal sector, who remains vulnerable and unrepresented. Job creation initiatives have been undermined by the global recession and infrastructural shortcomings and ambitious governmental targets appear

  7. Eighth Five-Year Plan Achievements and Ninth Five-Year Targets for CNPC

    Institute of Scientific and Technical Information of China (English)

    Zhou Yongkang

    1996-01-01

    @@ Through more than 40 years of development since the founding of the new China its onshore petroleum industry has already possessed considerably abundant economic and technical strength. Altogether 21 oil and gas producing bases have been established; a total length of 17thousand kilomers oil and gas pipelines have been constructed; 300thousand sets of various kinds of facilities have been equipped,including 816 large and mediumsized rigs; and a well-trained and rather completed petroleum professional contingent has been brougt up with annual operation capabilities of drilling footage of 20 million meters,building crude oil productivity of 20 million tons,and laying long-distance pipelines of 2 thousand kilometers.

  8. Optimizing the role of tax auditor in attempt to achieve tax revenue target

    OpenAIRE

    Mawan Setianto; Hamidah Hamidah

    2016-01-01

    This study aims to explain the role of Tax Auditor in KPP Madya Surabaya. This study uses a case study by collecting the data from Directorate General of Taxation official sources, either in KPP Madya Surabaya, Regional Office of Directorate General of Taxation East Java I, as well as the Directorate of Potency, Compliance, and Revenue. Researcher also conducted interviews with 12 informants consisting of Tax Auditor, Account Representative, Head of Office, as well as officials from the Direc...

  9. Are European Bioenergy Targets Achievable? An Evaluation Based on Thermoeconomic and Environmental Indicators

    International Nuclear Information System (INIS)

    The goal of the research project is dual. Firstly, the creation of a multidimensional model (3E-model) that could be used to assess how sustainable it is to produce 2nd generation biofuels in a specific region or country and at any scale. Unlike the previously mentioned methods, this new multidimensional model integrates 3 key parameters for a more accurate evaluation, i.e., efficiency, economic and environmental impact analysis. Secondly, the model is applied to predict the feasibility of producing and implementing different biofuels (i.e., SNG, methanol, Fischer-Tropsch fuels and H2) or bioelectricity in Europe. The outcome of this analysis gives an overview of which countries are more promising in terms of production and distribution costs as well as CO2 emissions reduction. Moreover, the accomplishment of the European Energy Policy (i.e., 20% share of renewable energy by 2020) is also discussed. Chapter 2 is devoted to introduce biomass availability in Europe, its distribution across the different regions and its composition. Chapter 3 deals with the design of the whole biomass-to-bioenergy conversion routes (i.e., from biomass collection to final biofuel application). Mass and energy balances from Aspen Plus simulations are used in Chapter 4 to calculate the efficiency of biomass-to-bioenergy conversion plants from an energetic and exergetic point of view. A Life Cycle Analysis (LCA) methodology is applied in Chapter 5 to quantify all emissions from the different bioenergy chains. In Chapter 6, mass and energy balances from Aspen Plus simulations are exported to Aspen Icarus to calculate biofuels and bioelectricity 'ex-work' prices. Results from previous chapter are combined in Chapter 7 to build an own multidimensional 3E model. In Chapter 8 the multidimensional model is applied at European scale. Finally, the main conclusions of this thesis are presented in Chapter 9 together with the recommendations for future work.

  10. Optimizing the role of tax auditor in attempt to achieve tax revenue target

    Directory of Open Access Journals (Sweden)

    Mawan Setianto

    2016-04-01

    Full Text Available This study aims to explain the role of Tax Auditor in KPP Madya Surabaya. This study uses a case study by collecting the data from Directorate General of Taxation official sources, either in KPP Madya Surabaya, Regional Office of Directorate General of Taxation East Java I, as well as the Directorate of Potency, Compliance, and Revenue. Researcher also conducted interviews with 12 informants consisting of Tax Auditor, Account Representative, Head of Office, as well as officials from the Directorate of Inspection and Billing. There are discrepancies between the expectations of stakeholders and what being  understood/perceived and expected by the Tax Auditor in relation to the role that must be executed. This causes the Tax Auditor to experience a role ambiguity which disrupts the optimizing the implementation of the role. Things that still impede the implementation of the role of the Tax Auditor are: rejection of the Taxpayer; intervention both from inside and outside/difficult to implement the independence in appearance and independence in fact; both physically and psychologically threats; the unclear mutation policy; promotion criteria being implemented inconsistently; and databases that have not been accurate and reliable. 

  11. Targeted tumor radiotherapy

    Directory of Open Access Journals (Sweden)

    Unak Perihan

    2002-01-01

    Full Text Available Targeted tumor radiotherapy is selectively delivery of curative doses of radiation to malignant sites. The aim of the targeted tumor radiotherapy is to use the radionuclides which have high LET particle emissions conjugated to appropriate carrier molecules. The radionuclides are selectively collected by tumor cells, depositing lethal doses to tumor cells while no admission occur to normal cells. In theory, targeted radiotherapy has several advantages over conventional radiotherapy since it allows a high radiation dose to be administered without causing normal tissue toxicity, although there are some limitations in the availability of appropriate targeting agents and in the calculations of administered doses. Therefore, for routine clinical applications more progress is still needed. In this article, the potential use of targeted tumor radiotherapy is briefly reviewed. More general aspects and considerations, such as potential radionuclides, mechanisms of tumor targeting was also outlined.

  12. Inequality, SES, economic indicators, and student achievement

    OpenAIRE

    John J. McCreary; Edwards, Julianne M.; Gregory J. Marchant

    2015-01-01

    HLM model fit was used to determine the relationship of the country level economic variables of GDP and the GINI Index to 2012 student PISA reading, math, and science achievement, along with individual SES, country SES mean, and country SES inequality. For all achievement areas the complete model of all variables represented the best fit. The significant predictors in the models were country SES inequality and student SES. This suggested a less direct relationship to achievement for the econo...

  13. Predicting Academic Achievement from Classroom Behaviors

    OpenAIRE

    Flynt, Cynthia J.

    2008-01-01

    PREDICTING ACADEMIC ACHIEVEMENT FROM CLASSROOM BEHAVIORS by Cynthia J. Flynt Nancy Bodenhorn & Kusum Singh, Co-Chairs Counselor Education (ABSTRACT) This study examined the influence of behaviors exhibited in the classroom on reading and math achievement in the first, third and eighth grades; and the influence of teacher perceptions on reading and math achievement of African-Americans versus White students and male versus female students. Lastly, the study examined te...

  14. Predicting achievement in mathematics in adolescent students

    OpenAIRE

    Zupančič, Maja; PUKLEK LEVPUŠČEK, Melita; Sočan, Gregor

    2015-01-01

    The study examined individual factors and social factors that influence adolescent studentsʼ achievement in mathematics. The predictive model suggested direct positive effects of student intelligence, self-rated openness and parental education on achievement in mathematics, whereas direct effects of extraversion on measures of achievement were negative. Indirect positive effects of intelligence, self-rated conscientiousness, student-perceived mathematics teacherʼs press for understanding and ...

  15. Moving Target Defense

    CERN Document Server

    Jajodia, Sushil; Swarup, Vipin; Wang, Cliff; Wang, X Sean

    2011-01-01

    Moving Target Defense: Creating Asymmetric Uncertainty for Cyber Threats was developed by a group of leading researchers. It describes the fundamental challenges facing the research community and identifies new promising solution paths. Moving Target Defense which is motivated by the asymmetric costs borne by cyber defenders takes an advantage afforded to attackers and reverses it to advantage defenders. Moving Target Defense is enabled by technical trends in recent years, including virtualization and workload migration on commodity systems, widespread and redundant network connectivity, instr

  16. Deuterium High Pressure Target

    CERN Document Server

    Perevozchikov, V; Vinogradov, Yu I; Vikharev, M D; Ganchuk, N S; Golubkov, A N; Grishenchkin, S K; Demin, A M; Demin, D L; Zinov, V G; Kononenko, A A; Lobanov, V N; Malkov, I L; Yukhimchuk, S A

    2001-01-01

    The design of the deuterium high-pressure target is presented. The target having volume of 76 cm^3 serves to provide the experimental research of muon catalyzed fusion reactions in ultra-pure deuterium in the temperature range 80-800 K under pressures of up to 150 MPa. The operation of the main systems of the target is described: generation and purification of deuterium gas, refrigeration, heating, evacuation, automated control system and data collection system.

  17. Deuterium high pressure target

    International Nuclear Information System (INIS)

    The design of the deuterium high-pressure target is presented. The target having volume of 76 cm3 serves to provide the experimental research of muon catalyzed fusion reactions in ultra-pure deuterium in the temperature range 80-800 K under pressures of up to 150 MPa. The operation of the main systems of the target is described: generation and purification of deuterium gas, refrigeration, heating, evacuation, automated control system and data collection system

  18. Target Window Reliability

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    The target window design implemented and tested in experiments at ANL have performed without failure for the available beam of 6 mm FWHM on a 12 mm diameter target. However, scaling that design to a 25 mm diameter target size for a 12 mm FWHM beam has proven problematic. Combined thermal and mechanical (pressure induced) stresses and strains are too high to maintain the small coolant gaps and provide adequate fatigue lifetime.

  19. The ISOLDE target robots

    CERN Multimedia

    Maximilein Brice

    2002-01-01

    ISOLDE targets need to be changed frequently, around 80 times per year. The high radiation levels do not permit this to be done by human hands and the target changes are effected by 2 industrial robots (picture _01). On the left, in the distance, the front-end of the GPS (General Purpose Separator) is seen, while the HRS (High Resolution Separator) is at the right. Also seen are the doors to the irradiated-target storage.

  20. Bayesian multiple target tracking

    CERN Document Server

    Streit, Roy L

    2013-01-01

    This second edition has undergone substantial revision from the 1999 first edition, recognizing that a lot has changed in the multiple target tracking field. One of the most dramatic changes is in the widespread use of particle filters to implement nonlinear, non-Gaussian Bayesian trackers. This book views multiple target tracking as a Bayesian inference problem. Within this framework it develops the theory of single target tracking, multiple target tracking, and likelihood ratio detection and tracking. In addition to providing a detailed description of a basic particle filter that implements

  1. Target Assembly Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Target Assembly Facility integrates new armor concepts into actual armored vehicles. Featuring the capability ofmachining and cutting radioactive materials, it...

  2. Targeting the tumor microenvironment

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  3. Achievement Goals and Discrete Achievement Emotions: A Theoretical Model and Prospective Test

    Science.gov (United States)

    Pekrun, Reinhard; Elliot, Andrew J.; Maier, Markus A.

    2006-01-01

    A theoretical model linking achievement goals to discrete achievement emotions is proposed. The model posits relations between the goals of the trichotomous achievement goal framework and 8 commonly experienced achievement emotions organized in a 2 (activity/outcome focus) x 2 (positive/negative valence) taxonomy. Two prospective studies tested…

  4. A windowless gas target for secondary beam production

    CERN Document Server

    Kishida, T; Shibata, M; Watanabe, H; Tsutsumi, T; Motomura, S; Ideguchi, E; Zhou, X H; Morikawa, T; Kubo, T; Ishihara, M

    1999-01-01

    A windowless gas target was developed for the production of secondary high-spin isomer beams (HSIB). An sup 1 sup 6 O target in the compound form of CO sub 2 gas was used to produce a sup 1 sup 4 sup 5 sup m Sm beam by using an sup 1 sup 6 O( sup 1 sup 3 sup 6 Xe, 7n) sup 1 sup 4 sup 5 sup m Sm reaction. The target gas pressure was kept constant at 50 Torr. A target thickness of about 1 mg/cm sup 2 was achieved with a 10 cm target length. Gas was recirculated and the consumption was very little.

  5. Kinetic controlled affinity labeling of target enzyme with thioester chemistry.

    Science.gov (United States)

    Tomohiro, Takenori; Nakabayashi, Masahiro; Sugita, Yuka; Morimoto, Shota

    2016-08-01

    High specificity has been an important feature in affinity labeling for target profiling. Especially, to label targets via rapidly progressing reactions with consumption of ligand (probe), high specificity of reaction with common functional groups of target protein should be achieved without reactions with similar groups of non-target proteins. Herein, we demonstrate the kinetic controlled affinity labeling of acyl CoA synthetase using a fatty acid analogue containing a phenylthioester linkage. High specificity was attained by accelerating the labeling rate in the binding pocket. This approach could be useful for profiling a series of target enzymes and transporters in signal transduction pathways. PMID:27298000

  6. Achieving scale strategies for sustained competitive performance.

    Science.gov (United States)

    Grube, Mark E; Gish, Ryan S; Tkach, Sasha N

    2008-05-01

    Growth to achieve scale requires the following strategic initiatives: Having a clear understanding of what the organization is and what it wants to become. Ensuring a structured and rigorous growth process. Leveraging size to achieve benefits of scale. Recognizing the importance of physicians, ambulatory care, and primary care. Establishing and maintaining accountability as growth occurs.

  7. Attitudes and Achievement of Bruneian Science Students.

    Science.gov (United States)

    Dhindsa, Harkirat S.; Chung, Gilbert

    2003-01-01

    Evaluates attitudes towards and achievement in science of Form 3 students studying in single-sex and coeducational schools in Brunei. Results demonstrated significant differences in attitudes towards and achievement in science of male and female students in single-sex schools and students in coeducational schools. (Contains 46 references.)…

  8. School Achievement Strongly Predicts Midlife IQ

    Science.gov (United States)

    Spinks, Ruth; Arndt, Stephan; Caspers, Kristin; Yucuis, Rebecca; McKirgan, L. William; Pfalzgraf, Christopher; Waterman, Elijah

    2007-01-01

    The relationship between measures of IQ and standardized school achievement tests is well established at around r~0.5 when the two are measured in close proximity. The current paper examined the stability of this correlation when comparing elementary school achievement (grades 3-8) and midlife IQ. Iowa Adoption Study participants who had…

  9. Mathematics Achievement: Do Teachers Make a Difference?

    Science.gov (United States)

    Osman, Ahmad Farid; Ismail, Noor Azina

    2006-01-01

    This paper examines the effects of gender of teachers, teachers' qualification, experience and training on mathematics achievement among eighth grade students in Malaysia using data from the Third International Mathematics and Science Study (TIMSS) 2003. Only gender of teachers has significant influence on student's achievement in mathematics.

  10. The Effects of Ethnicity Upon School Achievement.

    Science.gov (United States)

    Cooper, James G.

    The study examined the effects of ethnicity, family income, adult education level, and unemployment rates on school achievement. Data were obtained from 85 public school districts in New Mexico which enrolled primarily Spanish-surnamed pupils. The composite achievement scores from the Comprehensive Tests of Basic Skills (CTBS) for grades 5 and 8…

  11. Brain Wave Analysis and School Achievement.

    Science.gov (United States)

    Wilson, Barry; And Others

    The Brain Wave Analyzer (BWA Ertl 02) was used to measure the brain potentials of 110 public school children. Resulting scores were correlated with concurrent measures of school achievement. Results indicate that certain brain wave scores have relatively low correlations with school achievement compared to traditional intelligence measures but may…

  12. A Historical Perspective on Closing Achievement Gaps

    Science.gov (United States)

    Guskey, Thomas R.

    2005-01-01

    Although much has been written recently about gaps in the achievement of different groups of students, the problem has been with us for many years. This manuscript presents a historical perspective of the problem, viewing it as one of reducing variation in students' achievement. Specifically, it reviews the work of renowned educator Benjamin S.…

  13. Multimedia Technology and Students' Achievement in Geography

    Science.gov (United States)

    DaSilva, Edmar Bernardes; Kvasnak, Robb Neil

    2012-01-01

    In this study done at a community college in South Florida, the achievements of students who spoke English as their second language who had attended their K-12 education outside the United States in their home countries, in a U.S. college course on world geography are compared with the achievements of students in the same classes who spoke English…

  14. Physical Environment and Middle Grade Achievement.

    Science.gov (United States)

    Chan, Tak Cheung

    This study measured the influence of air conditioning, carpeting, fluorescent lighting, and interior pastel coloring on the academic achievement of eighth grade Georgia pupils in 1975-76 when the variance due to socioeconomic status was statistically controlled. Analysis of covariance was used to compare the achievement scores of students on the…

  15. Education Watch: Achievement Gap Summary Tables.

    Science.gov (United States)

    Education Trust, Washington, DC.

    These summary tables focus on the state-by-state academic achievement of African American, Hispanic American, American Indian, Asian American, and white students. Data are presented on achievement gains by state (4th grade reading scale scores, 1992-1998; 8th grade science and scale scores, 1996-2000; 4th grade math scale scores, 1992-2000; and…

  16. Subgroup Achievement and Gap Trends: New York

    Science.gov (United States)

    Center on Education Policy, 2010

    2010-01-01

    In grade 8 (the only grade in which subgroup trends were analyzed by achievement level), New York showed a clear trend of gains in reading and math at the basic-and-above, proficient-and-above, and advanced levels for all major subgroups with just a few exceptions. Achievement gaps in reading and math also narrowed at grades 4 and 8 for most…

  17. Self-Esteem and Reading Achievement.

    Science.gov (United States)

    Sweet, Anne E.; Burbach, Harold J.

    This study investigated the directionality of the relationship between self-esteem and reading achievement in 286 students in Lynchburg, Virginia. During the first year of the three-year study, subjects were fourth, fifth, and sixth graders. The Coopersmith Self-Esteem Inventory and the SRA Achievement Series subscales were administered; sex and…

  18. Teaching for Successful Intelligence Raises School Achievement.

    Science.gov (United States)

    Sternberg, Robert J.; Torff, Bruce; Grigorenko, Elena

    1998-01-01

    A "successful intelligence" intervention improved school achievement for a group of 225 ethnically diverse third-graders, both on performance assessments measuring analytical, creative, and practical achievements and on conventional multiple-choice memory assessments. Teaching for triarchic thinking facilitates factual recall, because learning…

  19. Gene targeting in adult rhesus macaque fibroblasts

    Directory of Open Access Journals (Sweden)

    Wolf Don P

    2008-03-01

    Full Text Available Abstract Background Gene targeting in nonhuman primates has the potential to produce critical animal models for translational studies related to human diseases. Successful gene targeting in fibroblasts followed by somatic cell nuclear transfer (SCNT has been achieved in several species of large mammals but not yet in primates. Our goal was to establish the protocols necessary to achieve gene targeting in primary culture of adult rhesus macaque fibroblasts as a first step in creating nonhuman primate models of genetic disease using nuclear transfer technology. Results A primary culture of adult male fibroblasts was transfected with hTERT to overcome senescence and allow long term in vitro manipulations. Successful gene targeting of the HPRT locus in rhesus macaques was achieved by electroporating S-phase synchronized cells with a construct containing a SV40 enhancer. Conclusion The cell lines reported here could be used for the production of null mutant rhesus macaque models of human genetic disease using SCNT technology. In addition, given the close evolutionary relationship and biological similarity between rhesus macaques and humans, the protocols described here may prove useful in the genetic engineering of human somatic cells.

  20. The CNGS target

    CERN Multimedia

    Patrice Loïez

    2005-01-01

    The CERN Neutrinos to Gran Sasso (CNGS) target ‘magazine’ of five target units. Each unit contains a series of 10-cm long graphite rods distributed over a length of 2 m. It is designed to maximize the number of secondary particles produced and hence the number of neutrinos. One unit is used at a time to prevent over heating.

  1. Strategic Targeted Advertising

    NARCIS (Netherlands)

    A. Galeotti; J.L. Moraga-Gonzalez (José Luis)

    2003-01-01

    textabstractWe present a strategic game of pricing and targeted-advertising. Firms can simultaneously target price advertisements to different groups of customers, or to the entire market. Pure strategy equilibria do not exist and thus market segmentation cannot occur surely. Equilibria exhibit rand

  2. Treat to target in systemic lupus erythematosus: a commentary.

    Science.gov (United States)

    Ugarte-Gil, Manuel F; Burgos, Paula I; Alarcón, Graciela S

    2016-08-01

    Treat to target (T2T) strategies have proved to be useful in several chronic disorders, including Rheumatoid Arthritis. In systemic lupus erythematosus (SLE), T2T strategy has been proposed in order to control disease activity, improve health-related quality of life, and reduce morbidity and mortality. Remission would be the main target, but a low disease activity state (LDAS) could be an acceptable alternative. However, due to SLE protean manifestations, the operational definitions of both remission and LDAS are still in progress. The definitions of these targets, remission and LDAS, should include a validated disease activity index, the treatments allowed, and the minimum length of time the target should be maintained. Furthermore, achieving these targets should result in better disease outcomes such as reducing damage accrual. This review addresses the current state regarding these possible targets in SLE and the impact of achieving them in intermediate and long-term outcomes of this disease. PMID:27406378

  3. The Costs of Meeting the 2030 Sustainable Development Goal Targets on Drinking Water, Sanitation, and Hygiene

    OpenAIRE

    Hutton, Guy; Varughese, Mili

    2016-01-01

    A dedicated goal for water has recently been endorsed by the United Nations General Assembly as part of the sustainable development goal (SDG) framework. This study provides an assessment of the global costs of meeting the WASH-related targets of Goal #6. The targets assessed include achieving universal and equitable access to safe and affordable drinking water for all (target 6.1), achieving access to adequate and equitable sanitation and hygiene for all, and ending open defecation (target 6...

  4. Targeted therapy in lymphoma

    Directory of Open Access Journals (Sweden)

    Cavalli Franco

    2010-11-01

    Full Text Available Abstract Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma, such as aberrant signal transduction pathways, which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt/mammalian target of rapamycin (mTOR pathways are examples of pathological mechanisms that are being targeted in drug development efforts. Bortezomib (a small molecule protease inhibitor and the mTOR inhibitors temsirolimus, everolimus, and ridaforolimus are some of the targeted therapies currently being studied in the treatment of aggressive, relapsed/refractory lymphoma. This review will discuss the rationale for and summarize the reported findings of initial and ongoing investigations of mTOR inhibitors and other small molecule targeted therapies in the treatment of lymphoma.

  5. Can tourism deliver its "aspirational" greenhouse gas emission reduction targets?

    NARCIS (Netherlands)

    Scott, D.; Peeters, P.M.; Gössling, S.

    2010-01-01

    This review paper examines the greenhouse gas (GHG) emission reduction targets postulated by a range of organizations seeking to reduce the consequences of global climate change and how, or if, the global tourism sector can achieve its share of those targets. It takes both existing estimates of curr

  6. Nanobody-functionalized polymersomes for tumor-vessel targeting

    NARCIS (Netherlands)

    Debets, M.F.; Leenders, W.P.J.; Verrijp, K.; Zonjee, M.; Meeuwissen, S.A.; Otte-Holler, I.; Hest, J.C.M. van

    2013-01-01

    Targeted carrier systems (e.g., liposomes or nanoparticles) are used to specifically deliver drugs to a site of interest. Site-direction can be achieved by attachment of targeting molecules, such as peptides, DNA/RNA, or antibodies, to the surface of the carrier. Here, the formation of polymersomes

  7. Real Exchange Rate Targets, Nominal Exchange Rate Policies, and Inflation Real Exchange Rate Targets, Nominal Exchange Rate Policies, and Inflation

    Directory of Open Access Journals (Sweden)

    J. Saúl Lizondo

    1991-03-01

    Full Text Available Real Exchange Rate Targets, Nominal Exchange Rate Policies, and Inflation Thh paper examines the implications of some nominal exchange rate policies aimed or attaining a given real exchange rate target. A policy rule that sets the rate of nominal depreciation as a function of the departures of the real exchange rate from its target level is unable to achieve the target. In contrast, a policv rule that sets the change in the rate of depreciation as a function of those departures may lead the economy to the target, under certain conditions. However, this policy could also lead the economy to a process of accelerating inflation.

  8. Triplex-mediated genome targeting and editing.

    Science.gov (United States)

    Reza, Faisal; Glazer, Peter M

    2014-01-01

    Genome targeting and editing in vitro and in vivo can be achieved through an interplay of exogenously introduced molecules and the induction of endogenous recombination machinery. The former includes a repertoire of sequence-specific binding molecules for targeted induction and appropriation of this machinery, such as by triplex-forming oligonucleotides (TFOs) or triplex-forming peptide nucleic acids (PNAs) and recombinagenic donor DNA, respectively. This versatile targeting and editing via recombination approach facilitates high-fidelity and low-off-target genome mutagenesis, repair, expression, and regulation. Herein, we describe the current state-of-the-art in triplex-mediated genome targeting and editing with a perspective towards potential translational and therapeutic applications. We detail several materials and methods for the design, delivery, and use of triplex-forming and recombinagenic molecules for mediating and introducing specific, heritable, and safe genomic modifications. Furthermore we denote some guidelines for endogenous genome targeting and editing site identification and techniques to test targeting and editing efficiency. PMID:24557900

  9. Adaptive collaborative tracking for multiple targets

    International Nuclear Information System (INIS)

    This paper presents a new method for tracking multiple targets in video sequences. A common dilemma that multiple target tracking methods have to face in practice is reducing computational cost and addressing occlusion to achieve efficient and robust long-duration tracking. Existing methods mainly focus on deriving the measurement-to-track assignment through probabilistic analysis, in which the motions of targets are considered to be independent of each other. These methods tend to be computationally expensive due to the complexity of implementation for the visual tracking task. In this paper, we propose a collaboration model in which the acceleration difference between two targets is used to calculate the motion correlation value based on the two-dimensional Gaussian function. By the collaboration model, the location of occluded target is estimated using the motion information from other targets. In order to sense the occurrence of an occlusion accurately before estimating the location of target, we also propose a border-based occlusion decision method which is integrated into our tracking framework. The proposed approach is computationally efficient and robust. Experimental results exhibit the performance of the tracker based on our approach. (paper)

  10. SIMULTANEOUS MULTIPLE TARGET RECOGNITION USING POLARIZATION AGILE WAVES

    Institute of Scientific and Technical Information of China (English)

    Chen Xinwei; Zhao Jianzhong; Wu Wen

    2012-01-01

    A novel matching method for simultaneous multi-target recognition is proposed by jointly considering target's prior scattering knowledge and the polarization parameters of radar echoes.The matching coefficients are calculated for the judgment.MATLAB simulations show that several targets can be accurately recognized simultaneously,and a high recognition probability can be achieved in Monte Carlo simulations.The total execution time can be remarkably reduced in the Field Programmable Gate Array (FPGA) implementation of the matching procedure.

  11. Nanoparticle-based targeted gene therapy for lung cancer

    OpenAIRE

    Lee, Hung-Yen; Mohammed, Kamal A; Nasreen, Najmunnisa

    2016-01-01

    Despite striking insights on lung cancer progression, and cutting-edge therapeutic approaches the survival of patients with lung cancer, remains poor. In recent years, targeted gene therapy with nanoparticles is one of the most rapidly evolving and extensive areas of research for lung cancer. The major goal of targeted gene therapy is to bring forward a safe and efficient treatment to cancer patients via specifically targeting and deterring cancer cells in the body. To achieve high therapeuti...

  12. Effects of Cooperative Learning on Students’ Academic Achievement

    Directory of Open Access Journals (Sweden)

    Fariha Gull

    2015-08-01

    Full Text Available Multiple teaching methods are used by teachers in order to improve learning of students. The most popular is lecture method, while very effective is cooperative learning method. Later teaching method had been preferred for teaching science and languages as cited by previous research studies. However, in the subjects of social sciences and humanities, its importance cannot be ignored. Following study is an effort to determine effect of cooperative learning method on students’ achievement in subject of Education.  Qusi experimental design, with pre and post test of control and experimental group was used to achieve target of the study. Sample of the study consisted of 63 female students enrolled in grade 12 of a public college. An achievement test was used as a pre-test, the students were than divided in experimental and control groups. Multiple cooperative learning activities were performed with experimental group by using three common methods of cooperative learning i.e., STAD, TGT and Jigsaw II. The control group was taught by lecture method only. After 8 weeks a post test was administered on both experimental and control group in order to identify difference in achievement. The independent sample t-test was used to measure the mean scores difference between achievement scores of control and treatment groups on pretest.  The results showed that there was no significant difference between the two groups (p=.825 leading to assumption that both groups were on equal level of achievement before intervention.  Same test was applied to find out difference between two groups before and after intervention.  The results showed that there was a significant difference in scores of control and experimental group in post-test. In addition to this paired sample t-test was conducted to compare the effect of intervention on achievement scores of experimental group.  The results showed that there was significant difference between scores of experimental

  13. Student academic achievement in college chemistry

    Science.gov (United States)

    Tabibzadeh, Kiana S.

    General Chemistry is required for variety of baccalaureate degrees, including all medical related fields, engineering, and science majors. Depending on the institution, the prerequisite requirement for college level General Chemistry varies. The success rate for this course is low. The purpose of this study is to examine the factors influencing student academic achievement and retention in General Chemistry at the college level. In this study student achievement is defined by those students who earned grades of "C" or better. The dissertation contains in-depth studies on influence of Intermediate Algebra as a prerequisite compared to Fundamental Chemistry for student academic achievement and student retention in college General Chemistry. In addition the study examined the extent and manner in which student self-efficacy influences student academic achievement in college level General Chemistry. The sample for this part of the study is 144 students enrolled in first semester college level General Chemistry. Student surveys determined student self-efficacy level. The statistical analyses of study demonstrated that Fundamental Chemistry is a better prerequisite for student academic achievement and student retention. The study also found that student self-efficacy has no influence on student academic achievement. The significance of this study will be to provide data for the purpose of establishing a uniform and most suitable prerequisite for college level General Chemistry. Finally the variables identified to influence student academic achievement and enhance student retention will support educators' mission to maximize the students' ability to complete their educational goal at institutions of higher education.

  14. Nuclear target development

    Energy Technology Data Exchange (ETDEWEB)

    Greene, J.P.; Thomas, G.E.

    1995-08-01

    The Physics Division operates a target development laboratory that produces thin foil targets needed for experiments performed at the ATLAS and Dynamitron accelerators. Targets are not only produced for the Physics Division but also for other divisions and occasionally for other laboratories and universities. In the past year, numerous targets were fabricated by vacuum evaporation either as self-supporting foils or on various substrates. Targets produced included Ag, Au, {sup 10,11}B, {sup 138}Ba, Be, {sup 12}C, {sup 40}Ca, {sup 116}Cd, {sup 155,160}Gd, {sup 76}Ge, In, LID, {sup 6}LiH, Melamine, Mg, {sup 142,150}Nd, {sup 58}Ni, {sup 206,208}Pb, {sup 194}Pt, {sup 28}Si, {sup 144,148}Sm, {sup 120,122,124}Sn, Ta, {sup 130}Te, ThF{sub 4}, {sup 46,50}Ti, TiH, U, UF{sub 4}, {sup 182}W and {sup 170}Yb. Polypropylene and aluminized polypropylene, along with metallized Mylar were produced for experiments at ATLAS. A number of targets of {sup 11}B of various thickness were made for the DEP 2-MeV Van de Graff accelerator. An increased output of foils fabricated using our small rolling mill included targets of Au, C, {sup 50}Cr, Cu, {sup 155,160}Gd, Mg, {sup 58}Ni, {sup 208}Pb, {sup 105,110}Pd. Sc, Ti, and {sup 64,66}Zn.

  15. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing of stainless steel. At the entrance to the target assembly was a scintillator screen, imprinted with circles every 5 mm in radius, which allowed to precisely aim the 26 GeV high-intensity proton beam from the PS onto the centre of the target rod. The scintillator screen was a 1 mm thick plate of Cr-doped alumina. See also 7903034 and 7905091.

  16. Internal polarized targets

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, E.R.; Coulter, K.; Gilman, R.; Holt, R.J.; Kowalczyk, R.S.; Napolitano, J.; Potterveld, D.H.; Young, L. (Argonne National Lab., IL (USA)); Mishnev, S.I.; Nikolenko, D.M.; Popov, S.G.; Rachek, I.A.; Temnykh, A.B.; Toporkov, D.K.; Tsentalovich, E.P.; Wojtsekhowski, B.B. (AN SSSR, Novosibirsk (USSR). Inst. Yadernoj Fiziki)

    1989-01-01

    Internal polarized targets offer a number of advantages over external targets. After a brief review of the basic motivation and principles behind internal polarized targets, the technical aspects of the atomic storage cell will be discussed in particular. Sources of depolarization and the means by which their effects can be ameliorated will be described, especially depolarization by the intense magnetic fields arising from the circulating particle beam. The experience of the Argonne Novosibirsk collaboration with the use of a storage cell in a 2 GeV electron storage ring will be the focus of this technical discussion. 17 refs., 11 figs.

  17. STIS target acquisition

    Science.gov (United States)

    Kraemer, Steve; Downes, Ron; Katsanis, Rocio; Crenshaw, Mike; McGrath, Melissa; Robinson, Rich

    1997-01-01

    We describe the STIS autonomous target acquisition capabilities. We also present the results of dedicated tests executed as part of Cycle 7 calibration, following post-launch improvements to the Space Telescope Imaging Spectrograph (STIS) flight software. The residual pointing error from the acquisitions are < 0.5 CCD pixels, which is better than preflight estimates. Execution of peakups show clear improvement of target centering for slits of width 0.1 sec or smaller. These results may be used by Guest Observers in planning target acquisitions for their STIS programs.

  18. Engineering professor achieves two prestigious professional milestones

    OpenAIRE

    Gilbert, Karen

    2005-01-01

    Ali Nayfeh of Blacksburg, University Distinguished Professor in the Department of Engineering Science and Mechanics in the College of Engineering at Virginia Tech, recently achieved two prestigious professional milestones.

  19. Recent CAS Achievements in Life Sciences

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    @@ Recent years have witnessed remarkable progress scored by CAS researchers along with the smooth development of the knowledge innovation program piloted at CAS. The follow-ings are just recent examples of CAS research achievements in life sciences.

  20. Adapting livestock behaviour to achieve management goals

    Science.gov (United States)

    Using livestock to efficiently achieve management goals requires melding animal behavior with mechanical and electronic equipment. Practices such as autonomously obtaining individual animal liveweight when combined with individual animal electronic identification can produce numerous cost saving ad...

  1. The integrated curriculum: experiences, achievements and problems.

    Science.gov (United States)

    Gale, J

    1984-01-01

    In this article the aims, experiences and achievements of vertical and horizontal integration in undergraduate medical education are considered and reviewed, and some problems are identified. It is concluded that a clearer definition of integration would now be helpful.

  2. Indochinese Refugee Families and Academic Achievement.

    Science.gov (United States)

    Caplan, Nathan; And Others

    1992-01-01

    The children of the Southeast Asian boat people excel in the U.S. school system. A review of the factors underlying this achievement suggests that the U.S. educational crisis is more social than academic. (KR)

  3. Achievements of school education in Finland

    OpenAIRE

    Mihail Brazhnik

    2010-01-01

    Discussed are specific traits of the evaluation of schools and students education achievements, as well as the specifics of the recruitment of teachers in Finland. Those are considered as factors improving the education quality.

  4. Layout optimization for multilayer overlay targets

    Science.gov (United States)

    Binns, L. A.; Smith, N. P.; Ausschnitt, C. P.; Morningstar, J.; Muth, W.; Schneider, J.; Yerdon, R.

    2006-03-01

    A novel overlay target developed by IBM and Accent Optical Technologies, Blossom, allows simultaneous overlay measurements of multiple layers (currently, up to 28) with a single target. This is achieved by a rotationally symmetric arrangement of small (4 micron) targets in a 50 micron square area, described more fully in a separate paper. In this paper, we examine the lessons learned in developing and testing the Blossom design. We start by examining proximity effects; the spacing of adjacent targets means that both the precision-like Total Measurement Uncertainty (TMU) and accuracy of a measurement can be affected by proximity of features. We use a mixture of real and modelled data to illustrate this problem, and find that the layout of Blossom reduces the proximity-induced bias. However, we do find that in certain cases proximity effects can increase the TMU of a particular measurement. The solution is to ensure that parts of the target that interact detrimentally are maximally separated. We present a solution to this, viewing the problem as a constrained Travelling Salesman Problem. We have imposed some global constraints, for example printing front-end and back-end layers on separate targets, and consistency with the overlay measurement strategy. Initially, we assume that pairwise measurements are either critical or non-critical, and optimize the layout so that the critical layers are both not placed adjacent to any prior or intermediate-layer features. We then build upon this structure, to consider the effect of low-energy implants (that cannot be seen once processed) and site re-use possibilities. Beyond this, we also investigate the impact of more strategic optimizations, for example, tuning the number of features on each layer. In each case, we present on-product performance data achieved, and modelled data on some additional target variants / extreme cases.

  5. Research on the intelligent control simulation target with IR imaging target for hardware-in-the-loop simulation test

    Science.gov (United States)

    Dong, Key-an; Gu, Ye; An, Yan; Meng, Xiang-kai; Lou, Yan; Zhang, Ya-lin; Zhan, Juntong; Song, Yan-song; Dong, Yan; Tong, Shou-feng

    2014-11-01

    The intelligent control of simulation target with infrared imaging target in the indoor and outdoor environment can effectively and quantitatively evaluated the parameters such as the minimum resolution temperature difference (MRTD) and spatial resolution of airborne forward looking infrared, infrared detection and tracking, infrared alarm, and etc. This paper focused on introducing the working principles of the intelligent control simulation target of Infrared imaging target, studying the thermal radiation characteristics of the infrared target surface material, analyzing the influences of the infrared radiation energy distribution, and developing the intelligent control simulation target with IR imaging target for hardware-in-the-loop simulation test. The intelligent control simulation target which area was 5 m2 and concluded 44 infrared targets including two kinds of infrared targets ,0.25m×0.25m;, and 0.25m×0.5m, achieved 1°~10° temperature simulation of target and the background, and temperature control precision better than 0.5°. Field test requirements were achieved by actual test.

  6. Identifying learning techniques among high achievers

    OpenAIRE

    Shanmukananda P; L. Padma

    2013-01-01

    Background: In every college, it is noticed that in spite of being exposed to the same teaching modalities and adopting seemingly similar strategies, some students perform much better than their peers. This can be evaluated in the form of better academic performance in the internal assessments they undertake. This project is an endeavor to identify the learning techniques among high achievers which they employ to outperform others. We can also suggest the same to the medium and low achievers ...

  7. Identifying learning techniques among high achievers

    Directory of Open Access Journals (Sweden)

    Shanmukananda P

    2013-04-01

    Full Text Available Background: In every college, it is noticed that in spite of being exposed to the same teaching modalities and adopting seemingly similar strategies, some students perform much better than their peers. This can be evaluated in the form of better academic performance in the internal assessments they undertake. This project is an endeavor to identify the learning techniques among high achievers which they employ to outperform others. We can also suggest the same to the medium and low achievers so that they can improve their academic performance. This study was conducted to identify different learning techniques adopted by high achievers and suggesting the same to medium and low achievers. Methods: After obtaining clearance from the institutional ethics committee, the high achievers were identified by selecting the upper third of the students in the ascending order of marks obtained in the consecutive three internal assessments in three consecutive batches. The identity of the students was not revealed. They were then administered an open ended questionnaire which addressed relevant issues. The most common and feasible techniques will be suggested to the medium and low achievers. Results: The respondents’ (n=101 replies were analyzed by calculating the percentages of responses, and assessing based on that, which were the most frequently adapted techniques by these high achievers Conclusions: High-achievers have a diligent study pattern; they not only study regularly, but also involve in group discussions and approach their teachers when in doubt. Additionally, they refer to other sources of information like the internet, demonstrating a proactive attitude towards studies. [Int J Basic Clin Pharmacol 2013; 2(2.000: 203-207

  8. Intelligence and Its Relationship to Achievement

    OpenAIRE

    Fatih KAYA; Juntune, Joyce; Stough, Laura

    2015-01-01

    Intelligence and achievement are two different, but interrelated, constructs and have been studied for over a century in an attempt to explain differences in educational and life outcomes. An enhanced understanding of the relationship between intelligence, both verbal and nonverbal, and achievement may contribute to improving the identification of gifted and talented children, particularly those from low SES populations. This comprehensive literature review examines the link between intellige...

  9. Achieving quality in procurement through automation

    OpenAIRE

    Jacunski, Walter W.

    1990-01-01

    Approved for public release; distribution is unlimited. Department of Defense has mandated that TQM be implemented in procurement. This research looks at achieving quality in procurement through the use of information systems. In doing so, it defines what quality in procurement means. The armed services; three automated systems: APADE, BCAS, and SAACONS are analyzed to see what tools they provide users to aid them in achieving procurement quality. It gives suggestions on how information sy...

  10. Low and high achievers in math

    DEFF Research Database (Denmark)

    Overgaard, Steffen; Tonnesen, Pia Beck; Weng, Peter;

    2015-01-01

    In this session we will present the results of the preliminary analysis of the qualitative and quantitative data, which can be used to enhance the teaching of low and high mathematics achievers so as to increase their mathematical knowledge and confidence.......In this session we will present the results of the preliminary analysis of the qualitative and quantitative data, which can be used to enhance the teaching of low and high mathematics achievers so as to increase their mathematical knowledge and confidence....

  11. Hypoxia-mediated tumour targeting.

    Science.gov (United States)

    Binley, K; Askham, Z; Martin, L; Spearman, H; Day, D; Kingsman, S; Naylor, S

    2003-04-01

    Hypoxia is a common physiological feature of tumours. It activates a signalling cascade that culminates in the stabilization of the HIF-1 transcription factor and activation of genes that possess a hypoxia response element (HRE). We have used an optimized hypoxia responsive promoter (OBHRE) to investigate hypoxia-targeted gene expression in vivo in the context of an adenovirus vector. The OBHRE promoter showed limited activity in the liver or spleen such that expression was 1000-fold lower than that driven by the strong CMV/IE promoter. However, in the context of the tumour microenvironment, the OBHRE promoter achieved expression levels comparable to that of the CMV/IE promoter. Next, we showed that an adenovirus expressing the human cytochrome P450 (CYP2B6) regulated by the OBHRE promoter delays tumour growth in response to the prodrug cyclophosphamide (CPA). Finally, we exploited the hepatotropism of adenovirus to investigate whether the OBHRE promoter could mitigate the hepatotoxicity of a recombinant adenovirus expressing thymidine kinase (TK) in the context of the prodrug ganciclovir (GCV). High-dose Ad.CMVTK/GCV treatment caused significant liver necrosis whereas the same dose of Ad.HRETK was well tolerated. These in vivo data demonstrate that hypoxia-targeted gene expression via the OBHRE promoter can be used to increase the therapeutic window of cytotoxic cancer gene therapy. PMID:12646859

  12. Achievement Goals, Learning Strategies and Language Achievement among Peruvian High School Students

    Directory of Open Access Journals (Sweden)

    Lennia Matos

    2007-05-01

    Full Text Available We used an achievement goal framework to study the role of motivation in the academic context of a Peruvian sample of 8th to 10th grade high school students (N = 1505. The purpose of this cross-sectional study was to examine the relationship between students' achievement goals, their use of learning strategies and their academic achievement. Multiple Hierarchical Regressions Analyses identified, as predicted, positive effects of mastery goals, including more use of learning strategies and higher academic achievement, and negative effects of performance avoidance goals, including lower academic achievement. Mixed results were found for pursuing performance approach goals, which predicted a greater use of learning strategies, but were unrelated to academic achievement. The present findings support the external validity of achievement goal theory in a sample of students from a culture that is understudied in the achievement goal literature in particular and the motivational literature in general.

  13. Target Price Accuracy

    Directory of Open Access Journals (Sweden)

    Alexander G. Kerl

    2011-04-01

    Full Text Available This study analyzes the accuracy of forecasted target prices within analysts’ reports. We compute a measure for target price forecast accuracy that evaluates the ability of analysts to exactly forecast the ex-ante (unknown 12-month stock price. Furthermore, we determine factors that explain this accuracy. Target price accuracy is negatively related to analyst-specific optimism and stock-specific risk (measured by volatility and price-to-book ratio. However, target price accuracy is positively related to the level of detail of each report, company size and the reputation of the investment bank. The potential conflicts of interests between an analyst and a covered company do not bias forecast accuracy.

  14. Targeted therapies for cancer

    Science.gov (United States)

    ... to be untrue. Possible side effects from targeted therapies include: Diarrhea Liver problems Skin problems such as rash, dry skin, and nail changes Problems with blood clotting and wound healing High blood pressure As with any treatment, you ...

  15. Measuring achievement motivation at early adolescent age

    Directory of Open Access Journals (Sweden)

    Vasić Aleksandar

    2014-01-01

    Full Text Available Using the sample of adult respondents from the domestic population we defined the structure of achievement motivation with four relatively independent dimensions of competing with others, perseverance in achieving goals, achieving goals as a source of pleasure and orientation towards planning. Based on this model we constructed the MOP/D scale for measuring achievement motivation at early adolescent age, containing 35 items and three-level categories of responses. This scale was administered together with the questionnaires exploring the motivation for school learning and personality features on the initial sample (261 respondents; 48% female and the cross-validation sample (2234 respondents; 49% female aged 10 to 16. It has been shown that the MOP/D scale is highly representative, with excellent reliability, and, considering the expected complexity of the space of measuring, acceptable homogeneity. Using the exploratory factor analysis on both samples, four primary dimensions were defined: planning, studying, competing and perseverance, and the general factor of achievement motivation. The results of correlation analyses revealed satisfactory criterion, convergent and discriminatory validity of the MOP/D scale against the measures of academic motivation, personality features and the variables derived from data on school success. Hence, the MOP/D scale has good psychometric characteristics and can be applied in research and practical psychological activities for measuring achievement motivation of respondents at early adolescent age.

  16. ASSOCIATION BETWEEN EMOTIONAL VARIABLES AND SCHOOL ACHIEVEMENT

    Directory of Open Access Journals (Sweden)

    Christoph Randler

    2009-07-01

    Full Text Available Recent psychological studies highlight emotional aspects, and they show an important role within individual learning processes. Hereby, positive emotions were supposed to positively influence learning and achievement processes and negative ones do the contrary. In this study, an educational unit “ecosystem lake” was used during which achievement (three tests and emotional variables (interest, well-being, anxiety and boredom; measured at the end of three pre-selected lessons were monitored. The research question was to explore correlations between emotional variables and the learning outcome of the teaching unit. Prior knowledge was regressed against the subsequent tests to account for its confounding effect. Regressions showed a highly significant influence of prior knowledge on the subsequent measurements of achievement. However, after accounting for prior knowledge, a positive correlation between interest/well-being and achievement and a negative correlation between anxiety/boredom and achievement was found. Further research and interventions should try to enhance positive emotions in biology lessons to positively influence achievement.

  17. Code Compliant School Buildings Boost Student Achievement

    Directory of Open Access Journals (Sweden)

    Ronald B. Lumpkin

    2014-11-01

    Full Text Available Much of the focus in the literature in raising student achievement has included parental involvement, principal leadership, quality of instruction, students’ socioeconomic status, curriculum, and use of technology. Limited empirical research relates the condition of the school building as a variable that affects student achievement. Furthermore, there is no research that has examined the impact of building codes on achievement outcomes in the state of Florida. This research determined whether academic achievement of 4th-, 8th-, 9th-, and 10th-grade students as measured by the mathematics and reading subtests of the Florida Comprehensive Achievement Test (FCAT increased in new school buildings compliant to the 2000 Florida State Requirements for Educational Facilities. A causal-comparative design determined whether the independent variables, old and new school building influenced student achievement as measured by students’ FCAT mathematics and reading subtest scores. The control group was two cohorts of 4th-, 8th-, 9th-, and 10th-grade students who attended school in old buildings. The experimental group was two cohorts of 4th-, 8th-, 9th-, and 10th-grade students who attended school in new buildings. Transition from an old school into a new school was the treatment. Two hypotheses were formulated for testing and the research question for the inquiry was whether the percentage of students passing the FCAT mathematics and reading subtests increases after transitioning from an old school building into a new 2000 UBC (Uniform Building Code compliant facility.

  18. ACADEMIC ACHIEVEMENT OF B.ED STUDENTS IN RELATION TO INTELLIGENCE AND ACHIEVEMENT MOTIVATION

    OpenAIRE

    Avanish Kumar

    2015-01-01

    The study was experimental in nature and conducted on the sample of 300 students, as per the requirements of 2*2 factorial design in which the independent variables of Intelligence and Achievement Motivation were studied. Academic Achievement was taken as a dependent variable. There were two levels of Intelligence – High Group Intelligence (I1) and Low Group Intelligence (I2) and two levels of the variable Achievement Motivation (A) – High Achievement Motivation (A1) & Low Achi...

  19. Achieving Sustainable Value Planning For Malaysian Public Projects

    Directory of Open Access Journals (Sweden)

    Muhammad Faudzi

    2016-01-01

    Full Text Available Sustainability is the central development issue in the modern economy. Through sustainable development, quality of life can be improved or maintained over time. Since Malaysia is targeting to become a high-income nation by the year 2020, financial investment in public projects should be planned comprehensively so that it will generate immediate and long-term benefits to the country and the people. Within the currently tight financial environment, achieving value for money in public spending is seen as one of the enablers to maintain the right momentum of economic growth. Previous studies have established the importance of integrating sustainability consideration into Value Planning protocol in order to achieve value for money, underpinned by the sustainable development agenda. Despite the establishment of the framework for the integration, the opportunity of such integration within the Malaysian Value Planning protocol for public projects remains unclear. The present state of sustainability consideration within the Value Planning practice should be first evaluated, so that potential interventions to enhance the integration can be introduced. Responding to the gap, this exploratory study was conducted. The data was collected by means of document analysis, interviews and observations; subsequently analysed using the Template Analysis technique. Based on the current practice of Value Planning in Malaysia, ten interventions are proposed to transform the present practice into Sustainable Value Planning. Sustainable Value Planning is seen as a comprehensive concept in achieving value for money in public spending underpinned by the overarching concept of sustainability

  20. Environmental management system objectives & targets results summary :

    Energy Technology Data Exchange (ETDEWEB)

    Vetter, Douglas Walter

    2014-04-01

    Sandia National Laboratories/New Mexicos (SNL/NM) Environmental Management System is the integrated approach for members of the workforce to identify and manage environmental risks. Each Fiscal Year (FY) SNL/NM performs an analysis to identify environmental aspects, and the environmental programs associated with them are charged with the task of routinely monitoring and measuring the objectives and targets that are established to mitigate potential impacts of SNL/NMs operations on the environment. An annual summary of the results achieved towards meeting established Sandia Corporation and SNL/NM Site-specific objectives and targets provides a connection to, and rational for, annually revised environmental aspects. The purpose of this document is to summarize the results achieved and documented in FY2013.

  1. Liposomes for cardiovascular targeting.

    Science.gov (United States)

    Levchenko, Tatyana S; Hartner, William C; Torchilin, Vladimir P

    2012-04-01

    Liposome-based pharmaceuticals used within the cardiovascular system are reviewed in this article. The delivery of diagnostic and therapeutic agents by plain liposomes and liposomes with surface-attached targeting antibodies or polyethylene glycol to prolong their circulation time and accumulation at vascular injuries, ischemic zones or sites of thrombi are also discussed. An overview of the advantages and disadvantages of liposome-mediated in vitro, ex vivo and in vivo targeting is presented, including discussion of the targeting of liposomes to pathological sites on the blood vessel wall and a description of liposomes that can be internalized by endothelial cells. Diagnostic liposomes used to target myocardial infarction and the relative importance of liposome size, targetability of immunoliposomes and prolonged circulation time on the efficiency of sealing hypoxia-induced plasma membrane damage to cardiocytes are discussed as a promising approach for therapy. The progress in the use of targeted liposomal plasmids for the transfection of hypoxic cardiomyocytes and myocardium is presented. Stent-mediated liposomal-based drug delivery is also reviewed briefly. PMID:22834079

  2. Radar target detection simulation

    Directory of Open Access Journals (Sweden)

    Tarig Ibrahim Osman

    2014-12-01

    Full Text Available Standard radar detection process requires that the sensor output is compared to a predetermined threshold. The threshold is selected based on a-priori knowledge available and/or certain assumptions. However, any knowledge and/or assumptions become in adequate due to the presence of multiple targets with varying signal return and usually non stationary background. Thus, any predetermined threshold may result in either increased false alarm rate or increased track loss. Even approaches where the threshold is adaptively varied will not perform well in situations when the signal return from the target of interest is too low compared to the average level of the background .Track-before-detect techniques eliminate the need for a detection threshold and provide detecting and tracking targets with lower signal-to-noise ratios than standard methods. However, although trackbefore-detect techniques eliminate the need for detection threshold at sensor's signal processing stage, they often use tuning thresholds at the output of the filtering stage .This paper presents a computerized simulation model for target detection process. Moreover, the proposed model method is based on the target motion models, the output of the detection process can easily be employed for maneuvering target tracking.

  3. An ISOLDE target unit

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    A good dozen different targets are available for ISOLDE, made of different materials and equipped with different kinds of ion-sources, according to the needs of the experiments. Each separator (GPS: general purpose; HRS: high resolution) has its own target. Because of the high radiation levels, robots effect the target changes, about 80 times per year. In the standard unit shown in picture _01, the target is the cylindrical object in the front. It contains uranium-carbide kept at a temperature of 2200 deg C, necessary for the isotopes to be able to escape. At either end, one sees the heater current leads, carrying 700 A. The Booster beam, some 3E13 protons per pulse, enters the target from left. The evaporated isotope atoms enter a hot-plasma ion source (the black object behind the target). The whole unit sits at 60 kV potential (pulsed in synchronism with the arrival of the Booster beam) which accelerates the ions (away from the viewer) towards one of the 2 separators.

  4. Linguistic validation of translation of the self-assessment goal achievement (saga) questionnaire from English

    OpenAIRE

    Piault Elisabeth; Doshi Sameepa; Brandt Barbara A; Angün Çolpan; Evans Christopher J; Bergqvist Agneta; Trocio Jeffrey

    2012-01-01

    Abstract Background A linguistic validation of the Self-Assessment Goal Achievement (SAGA) questionnaire was conducted for 12 European languages, documenting that each translation adequately captures the concepts of the original English-language version of the questionnaire and is readily understood by subjects in the target population. Methods Native-speaking residents of the target countries who reported urinary problems/lower urinary tract problems were asked to review a translation of the...

  5. Influence of Emotional Intelligence and Need for Achievement on Interpersonal Relations and Academic Achievement of Undergraduates

    Science.gov (United States)

    Afolabi, Olukayode Ayooluwa; Ogunmwonyi, Edosa; Okediji, Abayomi

    2009-01-01

    This study examined influence of emotional intelligence and need for achievement on interpersonal relations and academic achievement of undergraduates. Questionnaires were administered to one hundred and ten (110) subjects. The independent variables are emotional intelligence and need for achievement, while the dependent variables are…

  6. Social Perceptions of Achieving Students and Achievement Goals of Students in Malaysia and the Philippines

    Science.gov (United States)

    Bernardo, Allan B. I.; Ismail, Rosnah

    2010-01-01

    The study investigates the hypothesis that country differences in achievement goals of students are associated with differences in how students with different achievement goals are perceived by students in different cultures. University students from Malaysia and the Philippine were asked to complete questionnaires on their achievement goals and…

  7. Emerging Targets in Photopharmacology

    NARCIS (Netherlands)

    Lerch, Michael M; Hansen, Mickel J; van Dam, Gooitzen M; Szymanski, Wiktor; Feringa, Ben L

    2016-01-01

    The field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment. By using small molecules, photopharmacology provide

  8. Advances in Groundwater Remediation: Achieving Effective In Situ Delivery of Chemical Oxidants and Amendments

    DEFF Research Database (Denmark)

    Siegrist, Robert L.; Crimi, Michelle; Broholm, Mette Martina;

    2012-01-01

    ) delivered into the subsurface using injection wells, probes, or other techniques. A continuing challenge for ISCO, as well as other in situ remediation technologies, is how to achieve in situ delivery and obtain simultaneous contact between treatment fl uids, such as oxidants and amendments, and the target...... delivery of treatment fl uids, with an emphasis on chemical oxidants and amendments, which can help achieve cleanup goals and protect groundwater and associated drinking water resources....

  9. Computational design of nanoparticle drug delivery systems for selective targeting.

    Science.gov (United States)

    Duncan, Gregg A; Bevan, Michael A

    2015-10-01

    Ligand-functionalized nanoparticles capable of selectively binding to diseased versus healthy cell populations are attractive for improved efficacy of nanoparticle-based drug and gene therapies. However, nanoparticles functionalized with high affinity targeting ligands may lead to undesired off-target binding to healthy cells. In this work, Monte Carlo simulations were used to quantitatively determine net surface interactions, binding valency, and selectivity between targeted nanoparticles and cell surfaces. Dissociation constant, KD, and target membrane protein density, ρR, are explored over a range representative of healthy and cancerous cell surfaces. Our findings show highly selective binding to diseased cell surfaces can be achieved with multiple, weaker affinity targeting ligands that can be further optimized by varying the targeting ligand density, ρL. Using the approach developed in this work, nanomedicines can be optimally designed for exclusively targeting diseased cells and tissues.

  10. Effects of Gender, Mathematics Anxiety and Achievement Motivation on College Students’ Achievement in Mathematics

    Directory of Open Access Journals (Sweden)

    Ajogbeje Oke James

    2013-07-01

    Full Text Available The urge to excel or perform maximally in mathematics varies from individual to individual because achievement motivation is often developed or learnt during socialization and learning experiences. The study examined the relationship between College of Education students’ achievement motivation and mathematics achievement, correlation coefficient between mathematics anxiety and college students’ achievement motivation as well as mathematics anxiety and mathematics achievement. The sample, 268 College of Education students offering mathematics as one of their subject combination, was selected using purposive sampling techniques. Three research instruments namely: Mathematics Anxiety Scale (MAS, Achievement Motivation Scale (AMS and Mathematics Achievement Test (MAT were used to collect data for the study. Data collected for the study were analyzed using correlational analysis and ANOVA. The results showed that a significantly low negative correlation coefficient existed between mathematics anxiety and mathematics achievement. There is a negative and significant correlation coefficient between mathematics anxiety and achievement motivation. Similarly, a positive and significant correlation coefficient also exists between achievement motivation and mathematics achievement. Based on the findings of the study, it was recommended that mathematics teachers should adopt activity based strategies and conducive learning environment in order to reduce college students’ anxieties in mathematics learning.

  11. Factors Influencing Seminar Learning and Academic Achievement.

    Science.gov (United States)

    Spruijt, Annemarie; Leppink, Jimmie; Wolfhagen, Ineke; Bok, Harold; Mainhard, Tim; Scherpbier, Albert; van Beukelen, Peter; Jaarsma, Debbie

    2015-01-01

    Many veterinary curricula use seminars, interactive educational group formats in which some 25 students discuss questions and issues relating to course themes. To get indications on how to optimize the seminar learning process for students, we aimed to investigate relationships between factors that seem to be important for the seminar learning process, and to determine how these seminar factors account for differences in students' achievement scores. A 57-item seminar evaluation (USEME) questionnaire was administered to students right after they attended a seminar. In total, 80 seminars distributed over years 1, 2, and 3 of an undergraduate veterinary medicine curriculum were sampled and 988 questionnaires were handed in. Principal factor analysis (PFA) was conducted on 410 questionnaires to examine which items could be grouped together as indicators of the same factor, and to determine correlations between the derived factors. Multilevel regression analysis was performed to explore the effects of these seminar factors and students' prior achievement scores on students' achievement scores. Within the questionnaire, four factors were identified that influence the seminar learning process: teacher performance, seminar content, student preparation, and opportunities for interaction within seminars. Strong correlations were found between teacher performance, seminar content, and group interaction. Prior achievement scores and, to a much lesser extent, the seminar factor group interaction appeared to account for differences in students' achievement scores. The factors resulting from the present study and their relation to the method of assessment should be examined further, for example, in an experimental setup. PMID:26075625

  12. Feature analysis for indoor radar target classification

    Science.gov (United States)

    Bufler, Travis D.; Narayanan, Ram M.

    2016-05-01

    This paper analyzes the spectral features from human beings and indoor clutter for building and tuning Support Vector Machines (SVMs) classifiers for the purpose of classifying stationary human targets. The spectral characteristics were obtained through simulations using Finite Difference Time Domain (FDTD) techniques where the radar cross section (RCS) of humans and indoor clutter objects were captured over a wide range of frequencies, polarizations, aspect angles, and materials. Additionally, experimental data was obtained using a vector network analyzer. Two different feature sets for class discrimination are used from the acquired target and clutter RCS spectral data sets. The first feature vectors consist of the raw spectral characteristics, while the second set of feature vectors are statistical features extracted over a set frequency interval. Utilizing variables of frequency and polarization, a SVM classifier can be trained to classify unknown targets as a human or clutter. Classification accuracy over 80% can be effectively achieved given appropriate features.

  13. Lactosamination of liposomes and hepatotropic targeting research

    Institute of Scientific and Technical Information of China (English)

    Yong Peng Chen; Lian Zhang; Qiao Sheng Lu; Xiao Rong Feng; Kang Xian Luo

    2000-01-01

    Site-specific delivery of therapeutic drugs to their target cells is a major scientific challenge for the pharmaceutical sciences. It offers a number of advantages over conventional drug administration. With drug targeting, high local concentrations of the drug can be achieved, thus circumventing many unwanted side effects. Various carriers have been suggested for the delivery of drugs, including liposomes[1 - 5] and (neo ) glycoproteins[6-8]. The asialoglycoprotein receptor (ASGP-R) has frequently been utilized for targeting drugs to the parenchymal liver cell[6- 12]. Liposomes have several advantageous characteristics as drug carrier, and particularly, ligandtacked liposomes achieve a highly effective targeting[13]. Hara et al reported that asialofetuin (AF)-tacked liposomes distributed to rat hepatocytes selectively in vivo[14], and ASGP-R mediated the uptake of AF-liposomes encapsulating IFN-γ by isolated rat hepatocytes in vitro[15]. Lactosaminated human serum albumin (L-HSA) is a neoglycoprotein taking number of galactose residue as terminal sugar[6].

  14. Production Target Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olivas, Eric Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.  The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.  The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.  The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).  The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.  This report summarizes the current status of the plant target design.

  15. Achieving single channel, full duplex wireless communication

    KAUST Repository

    Choi, Jung Il

    2010-01-01

    This paper discusses the design of a single channel full-duplex wireless transceiver. The design uses a combination of RF and baseband techniques to achieve full-duplexing with minimal effect on link reliability. Experiments on real nodes show the full-duplex prototype achieves median performance that is within 8% of an ideal full-duplexing system. This paper presents Antenna Cancellation, a novel technique for self-interference cancellation. In conjunction with existing RF interference cancellation and digital baseband interference cancellation, antenna cancellation achieves the amount of self-interference cancellation required for full-duplex operation. The paper also discusses potential MAC and network gains with full-duplexing. It suggests ways in which a full-duplex system can solve some important problems with existing wireless systems including hidden terminals, loss of throughput due to congestion, and large end-to-end delays. Copyright 2010 ACM.

  16. Five years of achievement in ISCS

    Science.gov (United States)

    McDuffie, Thomas E., Jr.; Derose, James V.

    Achievement associated with a school district committed to the implementation of the Intermediate Science Curriculum Study (ISCS) materials and instructional strategy is the focus of this report. While ISCS is a three level, activity oriented, junior high program, the research was limited to the first year or Level I. Data were gathered from Level I students (mostly seventh graders) during a five year period. Analyses were per- formed to help answer questions such as: Are IQ and reading scores the highest correlates of achievement? Do IQ and reading correlates hold for both quantitative and qualitative indices of achievement? Do ISCS learning relationships hold over time? Are students able to evaluate how well they understand the concepts covered?Received: 21 June 1979; Revised: 11 March 1981;

  17. Inflation Forecast Targeting: Implementing and Monitoring Inflation Targets

    OpenAIRE

    Lars E.O. Svensson

    1996-01-01

    Inflation targeting is shown to imply inflation forecast targeting: the central bank's inflation forecast becomes an intermediate target. Inflation forecast targeting simplifies both implementing and monitoring of monetary policy. The inflation forecast is actually an ideal intermediate target: it is most correlated with the goal, easier to control than the goal, more observable than the goal, and very transparent. Money growth targeting generally leads to higher inflation variability than in...

  18. Predicting genetics achievement in nonmajors college biology

    Science.gov (United States)

    Mitchell, Angela; Lawson, Anton E.

    Students enrolled in a non-majors college biology course were pretested to determine their level of intellectual development, degree of field independence, mental capacity, amount of prior genetics knowledge, and amount of fluid intelligence. They were then taught a unit on Mendelian genetics. The only student variables found to not account for a significant amount of variance on a test of reading comprehension and/or a test of genetics achievement was amount of prior genetics knowledge. Developmental level was found to be the most consistent predictor of performance, suggesting that a lack of general hypothetico-deductive reasoning ability is a major factor limiting achievement among these students.

  19. Impact of Metacognition on Guitar Performance Achievement

    OpenAIRE

    YOKUŞ, Tuba

    2013-01-01

    This study has been carried out to determine the impact of the development of metacognition on guitar performance achievement in the individual instrument guitar lesson, which is included in the Bachelor’s program of Music Teacher Education in Marmara University Atatürk Faculty of Education, Department of Fine Arts Education, in Turkey. “Experimental Design with Pretest–Posttest Control Group” has been used, in order to achieve the objective of the study. The study sample (N=10) consists of g...

  20. Leadership Strategies: Achieving Personal and Professional Success.

    Science.gov (United States)

    Menaker, Ronald

    2016-01-01

    Physicians and allied health staff in healthcare are finding themselves in situations characterized by uncertainty, chaos, and ambiguity, with high levels of burnout. A major influence is an aging U.S. population, resulting in increasing cost and reimbursement pressures. Medical group practices need leaders who have the capability to thrive in this environment. This article presents an integrated leadership model offering strategies and insights gained from keeping a journal for 40 years. Strategies to be shared include leading self through learning, leading others by developing relationships, leading organizations by achieving excellence, and achieving work-life integration and synergy. PMID:27443052

  1. Ignition target design for the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Haan, S.W.; Pollaine, S.M.; Lindl, J.D. [Los Alamos National Laboratory, NM (United States)] [and others

    1996-06-01

    The goal of inertial confinement fusion (ICF) is to produce significant thermonuclear burn from a target driven with a laser or ion beam. To achieve that goal, the national ICF Program has proposed a laser capable of producing ignition and intermediate gain. The facility is called the National Ignition Facility (NIF). This article describes ignition targets designed for the NIF and their modeling. Although the baseline NIF target design, described herein, is indirect drive, the facility will also be capable of doing direct-drive ignition targets - currently being developed at the University of Rochester.

  2. High Range Resolution Profile Automatic Target Recognition Using Sparse Representation

    Institute of Scientific and Technical Information of China (English)

    Zhou Nuo; Chen Wei

    2010-01-01

    Sparse representation is a new signal analysis method which is receiving increasing attention in recent years.In this article,a novel scheme solving high range resolution profile automatic target recognition for ground moving targets is proposed.The sparse representation theory is applied to analyzing the components of high range resolution profiles and sparse coefficients are used to describe their features.Numerous experiments with the target type number ranging from 2 to 6 have been implemented.Results show that the proposed scheme not only provides higher recognition preciseness in real time,but also achieves more robust performance as the target type number increases.

  3. Phoenix Color Targets

    Science.gov (United States)

    2008-01-01

    These images of three Phoenix color targets were taken on sols 1 and 2 by the Surface Stereo Imager (SSI) on board the Phoenix lander. The bottom target was imaged in approximate color (SSI's red, green, and blue filters: 600, 530, and 480 nanometers), while the others were imaged with an infrared filter (750 nanometers). All of them will be imaged many times over the mission to monitor the color calibration of the camera. The two at the top show grains 2 to 3 millimeters in size that were likely lifted to the Phoenix deck during landing. Each of the large color chips on each target contains a strong magnet to protect the interior material from Mars' magnetic dust. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  4. Targeted Phototherapy (newer phototherapy

    Directory of Open Access Journals (Sweden)

    Zonunsanga

    2015-04-01

    Full Text Available Conventional phototherapy uses a whole body cabinet or body part machine such as hand, foot or scalp machines. They have many disadvantages due to which new phototherapy technique was then developed to overcome this situation. This new technique is called targeted phototherapy which includes excimer laser, intense pulse light system (IPL, photodynamic therapy and ultraviolet (UV light source with a sophisticated delivery system which is easy to be operated by hands. The mechanisms of action of targeted phototherapy systems are similar to those in conventional UVB/UVA therapy. They have many advantages like less chances of side effects, avoidance of exposure of unnecessary sites, faster response, shortening of the duration of treatments. But they have disadvantages like high costs and inability to use for extensive areas. This review article discusses targeted phototherapy in considerable to the mechanism of actions and advantages and disadvantages in comparison to the conventional phototherapy.

  5. Setting reference targets

    International Nuclear Information System (INIS)

    Reference Targets are used to represent virtual quantities like the magnetic axis of a magnet or the definition of a coordinate system. To explain the function of reference targets in the sequence of the alignment process, this paper will first briefly discuss the geometry of the trajectory design space and of the surveying space, then continue with an overview of a typical alignment process. This is followed by a discussion on magnet fiducialization. While the magnetic measurement methods to determine the magnetic centerline are only listed (they will be discussed in detail in a subsequent talk), emphasis is given to the optical/mechanical methods and to the task of transferring the centerline position to reference targets

  6. Plant targets for Pseudomonas syringae type III effectors: virulence targets or guarded decoys?

    Science.gov (United States)

    Block, Anna; Alfano, James R

    2011-02-01

    The phytopathogenic bacterium Pseudomonas syringae can suppress both pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) by the injection of type III effector (T3E) proteins into host cells. T3Es achieve immune suppression using a variety of strategies including interference with immune receptor signaling, blocking RNA pathways and vesicle trafficking, and altering organelle function. T3Es can be recognized indirectly by resistance proteins monitoring specific T3E targets resulting in ETI. It is presently unclear whether the monitored targets represent bona fide virulence targets or guarded decoys. Extensive overlap between PTI and ETI signaling suggests that T3Es may suppress both pathways through common targets and by possessing multiple activities. PMID:21227738

  7. Achieving Proficiency Goals through Competency Guidelines.

    Science.gov (United States)

    Bartz, Walter H.; Strasheim, Lorraine

    The Indiana Foreign Language Generic Competencies for Levels 1-4 define language-learning outcomes in terms of communicative competencies within generic cultural contexts. Nine cultural contexts (travel/transportation, the "world" of the target language, school and education, family and home, leisure time, meeting personal needs, world of work,…

  8. Advancing Academic Achievement in the Heterogeneous Classroom.

    Science.gov (United States)

    Casey, Linda; And Others

    This master's project analyzed the implementation of a program designed to address the academic needs of all students in a heterogeneous classroom. The targeted population consisted of secondary parochial school students from working and middle class backgrounds in or around a large midwestern metropolitan area. Problems of underachievement were…

  9. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling. In this picture, the 26 GeV high-intensity beam from the PS enters from the right, where a scintillator screen, with circles every 5 mm in radius, permits precise aim at the target centre. See also 7903034 and 7905094.

  10. Targeting peroxiredoxins against leukemia.

    Science.gov (United States)

    Liu, Chuan-Xu; Zhou, Hu-Chen; Yin, Qian-Qian; Wu, Ying-Li; Chen, Guo-Qiang

    2013-01-15

    Peroxiredoxins (Prx), a family of small non-seleno peroxidases, are important regulators for cellular reactive oxygen species (ROS), which contribute to many signaling pathways and pathogenesis of diseases. Targeting redox homeostasis is being developed as a promising therapeutic strategy for many diseases such as cancers. This mini-review attempts to focus on our recent discoveries on adenanthin as the first natural molecule to specifically target the resolving cysteines of Prx I and Prx II and thus inhibit their peroxidase activities, and its role in differentiation induction in vitro and in vivo of acute myeloid leukemic cells.

  11. Environmental campaigns against forest companies: What are the campaigns trying to achieve?

    Energy Technology Data Exchange (ETDEWEB)

    Gritten, D.; Gonzalez Olabarria, J. R.; Mola-Yudego, B.; Dominguez, G.

    2012-11-01

    Campaigns by environmental non-governmental organisations (ENGOs) can have far reaching consequences in determining the policies of governments and corporations. This paper examines campaigns targeting forestry companies to determine what makes a successful campaign. Over forty ENGOs completed a questionnaire defining what they perceive to constitute a successful campaign. The responses were analysed using Analytical Hierarchy Process. The results showed that campaigns by ENGOs have two main targets: changes in laws and the target group implementing the campaigns recommendation(s). Achieving these targets, for most, constitute a successful campaign. Subsequently, representatives of seven ENGOs were questioned to attain their perspectives of the results in comparison to campaigns they are conducting against forest enterprises. They supported the results of the questionnaire, but also felt that there are various other factors that need to be considered (e.g. the campaigns time frame and the possibility of having hidden targets) that increase the issues complexity. (Author) 49 refs.

  12. Recent Achievement of Gas Electron Multiplier

    Institute of Scientific and Technical Information of China (English)

    XIA Yi-ben; WANG Lin-jun; ZHANG Ming-long; YANG Ying; ZHANG Wei-li; RUAN Jian-feng

    2004-01-01

    Gas electron multiplier (GEM) as a novel gas detector, due to it's simple structure, high performance, well compatibility etc. ,is widely used in high-energy physics, nuclear physics and other fields. In this review, the principle, recent achievements,developments and applications of GEM are mainly described.

  13. Achievement Motivation Skill Training: Assisting Unmotivated Students.

    Science.gov (United States)

    Grossnickle, Donald R.

    1988-01-01

    Achievement motivation training addresses the needs of unmotivated, "turned-off" students by employing sequential self-improvement steps and other strategies such as videotape clips, games, simulations, music, role playing, modeling, career education, and small-group exercises. Includes eight references. (MLH)

  14. Athletics, Athletic Leadership, and Academic Achievement

    Science.gov (United States)

    Yeung, Ryan

    2015-01-01

    This study examines the relationship between athletics, athletic leadership, and academic achievement. This is likely to be a tricky issue as athletes and athletic leaders are not likely to be a random group of students. To address this issue I control for school fixed effects and instrument the endogenous variables with height. I find that…

  15. Student Academic Achievement: Report to the Provost.

    Science.gov (United States)

    Leas, David E.

    In fall 1991, the faculty and staff of New Mexico State University-Alamogordo (NMSU-A) designed and implemented a strategic planning process which incorporates a comprehensive annual review of various aspects of student academic achievement (SAA). The faculty-based SAA assessment process includes activities focused on classroom instruction,…

  16. Parenting Styles and Adolescents' Achievement Strategies.

    Science.gov (United States)

    Aunola, Kaisa; Stattin, Hakan; Nurmi, Jari-Erik

    2000-01-01

    Investigates the extents to which adolescents' achievement strategies are associated with the parenting styles they experience in their families. Respondents (N=354) identified four types of families: those with Authoritative; Authoritarian; Permissive; and Neglectful parenting styles. Results further reveal that adolescents from authoritative…

  17. Catholic High Schools and Rural Academic Achievement.

    Science.gov (United States)

    Sander, William

    1997-01-01

    A study of national longitudinal data examined effects of rural Catholic high schools on mathematics achievement, high school graduation rates, and the likelihood that high school graduates attend college. Findings indicate that rural Catholic high schools had a positive effect on mathematics test scores and no effect on graduation rates or rates…

  18. Active Learning Strategies and Vocabulary Achievement

    Science.gov (United States)

    Griffith, John R.

    2015-01-01

    Using a quantitative method of data collection, this research explored the question: Do active learning strategies used in grades 5 and 6 affect student vocabulary achievement in a positive or negative direction? In their research, Wolfe (2001), Headley, et al., (1995), Freiberg, et al., (1992), and Brunner (2009) emphasize the importance of…

  19. School Support for Lower Achieving Pupils.

    Science.gov (United States)

    Duffield, Jill

    1998-01-01

    Reports on a study in four Scottish schools (with differing socio-economic and school-effectiveness ratings) of how lower achieving students experience schooling. Emphasis is on the available pupil-support systems: learning support, behavioral support, and guidance services. (DB)

  20. IQ and Neuropsychological Predictors of Academic Achievement

    Science.gov (United States)

    Mayes, Susan Dickerson; Calhoun, Susan L.; Bixler, Edward O.; Zimmerman, Dennis N.

    2009-01-01

    Word reading and math computation scores were predicted from Wechsler Abbreviated Scale of Intelligence Full Scale IQ, 10 neuropsychological tests, and parent attention deficit hyperactivity disorder (ADHD) ratings in 214 general population elementary school children. IQ was the best single predictor of achievement. In addition, Digit Span…

  1. Closing the Achievement Gap on ACT & SAT

    Science.gov (United States)

    Anderson, David

    2010-01-01

    Research has focused on four groups of factors and the achievement gap: (1) student characteristics (high school GPA, attendance patterns, courses taken in high school, participation in extra-curricular activities, etc.); (2) family characteristics (family structure, in home, parents' level of education, mobility, etc.); (3) school-based…

  2. Achievements in Building The Legal System

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In the past three decades,people have gained an increasingly deeper under-standing of the law,and theories on democracy and justice have been en-riched.A socialist legal framework has been developing and the rule of law has becomea basic governing principle.China has made unprecedented achievements in promoting law-based governance.

  3. New Achievements in Well Logging Technology

    Institute of Scientific and Technical Information of China (English)

    Tan Tingdong

    1996-01-01

    @@ In the first five years of 1990s, new achievements made in China's onshore well logging technology have enhanced the benefits of exploration and development for complex oil and gas reservoirs and have thus showed the trend of the development of China's well logging technology towards the end of this century.

  4. Only Children, Achievement, and Interpersonal Orientation.

    Science.gov (United States)

    Falbo, Toni

    Many psychological theories point to the importance of siblings in individual personality development. The impact of sibling status on interpersonal and achievement orientation was examined with undergraduates (N=1782) who completed a series of objective personality measures and a background questionnaire. Sibling status was defined in terms of…

  5. Psychological Barriers to Achievement in Women.

    Science.gov (United States)

    Goldberg, Lois S.

    1982-01-01

    This study explored the relationships among birth order, number of course credits achieved, and personality integration for 56 women graduate students. No evidence of significant stress was found as these women approached career choice points, nor was there a significant effect from birth order. (Author/RD)

  6. Interplanetary monitoring platform engineering history and achievements

    Science.gov (United States)

    Butler, P. M.

    1980-01-01

    In the fall of 1979, last of ten Interplanetary Monitoring Platform Satellite (IMP) missions ended a ten year series of flights dedicated to obtaining new knowledge of the radiation effects in outer space and of solar phenomena during a period of maximum solar flare activity. The technological achievements and scientific accomplishments from the IMP program are described.

  7. Attributional Biases: More Barriers to Women's Achievement.

    Science.gov (United States)

    Falbo, Toni; And Others

    This paper presents three studies dealing with the use of attribution theory in the study of sex differences in achievement. These sex differences are measured in terms of task difficulty, ability, effort, and luck according to the model developed by Weiner, et al (1971). The studies attempt to expand the Weiner model to demonstrate that males and…

  8. Friend Influence on Achievement during Middle Childhood

    Science.gov (United States)

    DeLay, Dawn

    2013-01-01

    This study was designed to investigate friend influence on academic achievement and task avoidance during middle childhood in a sample of 794 participants in 397 stable same-sex friendship dyads (205 girl dyads and 192 boy dyads) from four municipalities in Finland: two in Central Finland, one in Western Finland, and one in Eastern Finland.…

  9. Mobile Learning and Achievement Goal Orientation Profiles

    Science.gov (United States)

    Asplund, Minna

    2014-01-01

    Students with different achievement goal orientations have different approaches towards learning and studying. There is a widespread interest to find an easy access into learning spaces for those students who have low motivation with fear of failure and academic withdrawal. Mobile learning offers an easily accessible chance with low threshold to…

  10. Different Pathways for Achieving Cleaner Urban Areas

    DEFF Research Database (Denmark)

    Schippl, J.; Gudmundsson, Henrik; Sørensen, Claus Hedegaard;

    2016-01-01

    . Achieve essentially CO2-free city logistics in major urban centres by 2030.'' With this paper we present and discuss a roadmap that deals with the question who needs to do what by when in order to reach the White Paper goal for urban transport. The ''stakeholder-driven'' roadmap was developed in the FP7...

  11. Physics Achievements from the Belle Experiment

    CERN Document Server

    Brodzicka, Jolanta; Chang, Paoti; Eidelman, Simon; Golob, Bostjan; Hayasaka, Kiyoshi; Hayashii, Hisaki; Iijima, Toru; Inami, Kenji; Kinoshita, Kay; Kwon, Youngjoon; Miyabayashi, Kenkichi; Mohanty, Gagan; Nakao, Mikihiko; Nakazawa, Hideyuki; Olsen, Stephen; Sakai, Yoshihide; Schwanda, Christoph; Schwartz, Alan; Trabelsi, Karim; Uehara, Sadaharu; Uno, Shoji; Watanabe, Yasushi; Zupanc, Anze

    2012-01-01

    The Belle experiment, running at the KEKB e+e- asymmetric energy collider during the first decade of the century, achieved its original objective of measuring precisely differences between particles and anti-particles in the B system. After collecting 1000 fb-1 of data at various Upsilon resonances, Belle also obtained the many other physics results described in this article.

  12. Assets and Educational Achievement: Theory and Evidence

    Science.gov (United States)

    Elliott, William; Sherraden, Michael

    2013-01-01

    This special issue of Economics of Education Review explores the role of savings and asset holding in post-secondary educational achievement. Most college success research has focused on income rather than assets as a predictor, and most college financing policy has focused on tuition support and educational debt, rather than asset accumulation.…

  13. The Methodological Nettle: ICT and Student Achievement

    Science.gov (United States)

    Chandra, Vinesh; Lloyd, Margaret

    2008-01-01

    A major challenge for researchers and educators has been to discern the effect of ICT use on student learning outcomes. This paper maps the achievements in Year 10 Science of two cohorts of students over two years where students in the first year studied in a traditional environment while students in the second took part in a blended or e-learning…

  14. Competition and achievement goals in work teams

    NARCIS (Netherlands)

    Heidemeier, H.; Bittner, Jenny V.

    2012-01-01

    This study examined how competition within teams influences which type of achievement goals employees adopt. We studied how dispositional learning-goal and performance-goal orientation interact with team-level competition and predict whether team members adopt state learning or performance achieveme

  15. Impact of School Technology on Student Achievement

    Science.gov (United States)

    Young, Larry Douglas, Jr.

    2012-01-01

    This study provides an overview of the impact of school technology on elementary students in grades three through five attending public schools in Indiana. The investigation focused on the impact of various technologies on student achievement as measured on Indiana Statewide Testing for Educational Progress-Plus (ISTEP+). Various comparisons were…

  16. Home Media and Children's Achievement and Behavior

    Science.gov (United States)

    Hofferth, Sandra L.

    2010-01-01

    This study provides a national picture of the time American 6- to 12-year-olds spent playing video games, using the computer, and watching TV at home in 1997 and 2003, and the association of early use with their achievement and behavior as adolescents. Girls benefited from computer use more than boys, and Black children benefited more than White…

  17. How Teacher Turnover Harms Student Achievement

    Science.gov (United States)

    Ronfeldt, Matthew; Loeb, Susanna; Wyckoff, James

    2013-01-01

    Researchers and policymakers often assume that teacher turnover harms student achievement, though recent studies suggest this may not be the case. Using a unique identification strategy that employs school-by-grade level turnover and two classes of fixed-effects models, this study estimates the effects of teacher turnover on over 850,000 New York…

  18. Is achievement in Australian chemistry gender based?

    Science.gov (United States)

    Beard, John; Fogliani, Charles; Owens, Chris; Wilson, Audrey

    1993-12-01

    This paper compares the performances of female and male secondary students in the 1991 and 1992 Australian National Chemistry Quizzes. Male students consistently achieved a higher mean score in all Year groups (7 to 12), even though the numbers of female and male entrants were approximately equal. Implications for class tests and assessment tasks are addressed.

  19. Positive Functions of Emotions in Achievement Sports

    Science.gov (United States)

    Puig, Nuria; Vilanova, Anna

    2011-01-01

    This article presents the results of two research projects on the emotions of men engaged in achievement outdoor sports. The conditions were analyzed under which emotions carry out positive functions. The question strikes us as a fundamental one, because it is of crucial importance when it comes to increasing sportspeople's success. The…

  20. Attitude, Gender and Achievement in Computer Programming

    Science.gov (United States)

    Baser, Mustafa

    2013-01-01

    The aim of this research was to explore the relationship among students' attitudes toward programming, gender and academic achievement in programming. The scale used for measuring students' attitudes toward programming was developed by the researcher and consisted of 35 five-point Likert type items in four subscales. The scale was administered to…

  1. Enhancing Communication and Achieving Mutual-benefits

    Institute of Scientific and Technical Information of China (English)

    Yu Gendang; Xu Jianmei

    2006-01-01

    @@ The Third China International Small & Medium Enterprises Fair and Sino-Italy Small &Medium Enterprises Fair was completed successfully The pageant for international small and medium enterprises, the third China International Small & Medium Enterprises Fair and Sino-Italy Small & Medium Enterprises Fair, was completed successfully recently in Guangzhou.During those several days, the fair has achieved great success.

  2. Goal Orientations and Adolescent Mathematics Achievement

    Science.gov (United States)

    Keys, Tran Dang

    2013-01-01

    Motivation is a fundamental educational challenge for adolescents in the United States, and particularly for immigrant youth. The motivation to achieve, especially in mathematics, declines during adolescence. Most of what is known about motivation is based on studies of predominately middle-class White students; yet the influx of immigrants over…

  3. Relationship of Study Habits with Mathematics Achievement

    Science.gov (United States)

    Odiri, Onoshakpokaiye E.

    2015-01-01

    The study examined the relationship of study habits of students and their achievement in mathematics. The method used for the study was correlation design. A sample of 500 students were randomly selected from 25 public secondary schools in Delta Central Senatorial District, Delta State, Nigeria. Questionnaires were drawn to gather data on…

  4. Addressing Achievement Gaps with Psychological Interventions

    Science.gov (United States)

    Yeager, David; Walton, Gregory; Cohen, Geoffrey L.

    2013-01-01

    Student psychology--how the classroom looks and feels from the perspective of the student--can powerfully affect motivation and learning, and experiments are increasingly showing that even brief interventions to change psychology can boost achievement over months or years. When paired with other structural reforms, social-psychological…

  5. Achieving Organisational Change through Values Alignment

    Science.gov (United States)

    Branson, Christopher M.

    2008-01-01

    Purpose: The purpose of this paper is to, first, establish the interdependency between the successful achievement of organisational change and the attainment of values alignment within an organisation's culture and then, second, to describe an effective means for attaining such values alignment. Design/methodology/approach: Literature from the…

  6. Can Code Switching Enhance Learners' Academic Achievement?

    Science.gov (United States)

    Simasiku, Liswani; Kasanda, Choshi; Smit, Talita

    2015-01-01

    There has been a high failure rate of Grade 10 learners in the year end examinations in the Caprivi Education Region of Namibia over a number of years. The objective of this study was to investigate whether the use of mother tongue in English medium classrooms enhanced learners' academic achievement.The study investigated 12 teachers at 12 schools…

  7. Student Perceptions of High-Achieving Classmates

    Science.gov (United States)

    Händel, Marion; Vialle, Wilma; Ziegler, Albert

    2013-01-01

    The reported study investigated students' perceptions of their high-performing classmates in terms of intelligence, social skills, and conscientiousness in different school subjects. The school subjects for study were examined with regard to cognitive, physical, and gender-specific issues. The results show that high academic achievements in…

  8. Developing a Motivational Model of College Achievement.

    Science.gov (United States)

    Tuckman, Bruce W.; Abry, Dennis

    This study involves developing a motivational model of college achievement. The predictor variables, which were procrastination tendency, self-efficacy, self-regulation, intrinsic value, outcome value, cognitive strategy, test anxiety, students grade goals, parent grade goals, and grade point average, as well as the criterion variable exam…

  9. Mathematics Achievement of Vietnamese Grade 5 Pupils

    Science.gov (United States)

    Griffin, Patrick

    2007-01-01

    This article reports the results of a national survey of mathematics achievement at the end of primary school in Vietnam. A sample of more than 72000 students were assessed from 61 provinces. The items were matched to the Vietnam Mathematics curriculum for Year 5 students. Using a skills audit of the items, a variable of Vietnamese mathematics…

  10. Five Companies Receive IDEA10 Achievement Awards

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ CARY, NC April 28, 2010 - The IDEA10 Achievement Awards, which recognize the best new nonwoven and engineered fabric products introduced in the past three years, were presented in six different categories during a special ceremony on the second day of IDEA10 International Engineered Fabrics Conference and Exposition, April 28, 2010, in Miami Beach, Florida.

  11. Five Companies Receive IDEA10 Achievement Awards

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Prestigious industry awards presented at IDEA10 in Miami Beach this week;special Entrepreneurial Award also presented at IDEA 10 CARY,NC April 28,2010-The IDEA10 Achievement Awards, which recognize the best new nonwoven and engineered fabric products introduced in the past three years,were presented in six different categories

  12. Culturalizing Achievement Goal Theory and Research

    Science.gov (United States)

    Zusho, Akane; Clayton, Karen

    2011-01-01

    This article is primarily designed to provide a cultural analysis of the literature on achievement goals. First, an overview of the four dominant approaches to the study of culture--namely, cross-cultural psychology, cultural psychology, indigenous psychology, and psychological anthropology--is offered. Second, we analyze the extant body of…

  13. Science Achievement of Secondary Agricultural Education Students

    Science.gov (United States)

    Clark, Sara Vicky

    2012-01-01

    The purposes of this quantitative descriptive and correlational study were to describe the science achievements of secondary agricultural education students and determine if the number of agricultural education courses passed, FFA involvement, and SAE participation would statistically significantly improve students' performance on science…

  14. Effects of Ability Grouping on Student Achievement.

    Science.gov (United States)

    Kulik, James A.; Kulik, Chen-Lin C.

    1987-01-01

    Examines the effect of within-class and between-class ability groupings on the academic achievement of gifted elementary and secondary level students. Results showed that gifted students gained more academically than they would have if they had been taught in heterogeneous classes. (PS)

  15. Accelerating Mathematics Achievement Using Heterogeneous Grouping

    Science.gov (United States)

    Burris, Carol Corbett; Heubert, Jay P.; Levin, Henry M.

    2006-01-01

    This longitudinal study examined the effects of providing an accelerated mathematics curriculum in heterogeneously grouped middle school classes in a diverse suburban school district. A quasi-experimental cohort design was used to evaluate subsequent completion of advanced high school math courses as well as academic achievement. Results showed…

  16. What Characterises High Achieving Students’ Mathematical Reasoning?

    OpenAIRE

    Haavold, Per Øystein

    2011-01-01

    This study investigates high achieving students’ mathematical reasoning when given an unfamiliar trigonometric equation. The findings indicate that the students’ way of thinking is strongly linked with imitative reasoning and only when they received some form of guidance, were they able to display flexible and creative mathematical reasoning.

  17. Molecular Targets of Cannabidiol in Neurological Disorders.

    Science.gov (United States)

    Ibeas Bih, Clementino; Chen, Tong; Nunn, Alistair V W; Bazelot, Michaël; Dallas, Mark; Whalley, Benjamin J

    2015-10-01

    Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use. Until recently, alleged clinical effects from anecdotal reports and the use of licensed cannabinoid medicines are most likely mediated by tetrahydrocannabinol by virtue of: 1) this cannabinoid being present in the most significant quantities in these preparations; and b) the proportion:potency relationship between tetrahydrocannabinol and other plant cannabinoids derived from cannabis. However, there has recently been considerable interest in the therapeutic potential for the plant cannabinoid, cannabidiol (CBD), in neurological disorders but the current evidence suggests that CBD does not directly interact with the endocannabinoid system except in vitro at supraphysiological concentrations. Thus, as further evidence for CBD's beneficial effects in neurological disease emerges, there remains an urgent need to establish the molecular targets through which it exerts its therapeutic effects. Here, we conducted a systematic search of the extant literature for original articles describing the molecular pharmacology of CBD. We critically appraised the results for the validity of the molecular targets proposed. Thereafter, we considered whether the molecular targets of CBD identified hold therapeutic potential in relevant neurological diseases. The molecular targets identified include numerous classical ion channels, receptors, transporters, and enzymes. Some CBD effects at these targets in in vitro assays only manifest at high concentrations, which may be difficult to achieve in vivo, particularly given CBD's relatively poor bioavailability. Moreover, several targets were asserted through experimental designs that demonstrate only correlation with a given target rather than a causal proof. When the molecular targets of CBD that were physiologically plausible were considered for their potential for exploitation in neurological therapeutics, the results were variable. In some cases

  18. Achievement Goals, Learning Strategies and Language Achievement among Peruvian High School Students

    OpenAIRE

    Lennia Matos; Willy Lens; Maarten Vansteenkiste

    2007-01-01

    We used an achievement goal framework to study the role of motivation in the academic context of a Peruvian sample of 8th to 10th grade high school students (N = 1505). The purpose of this cross-sectional study was to examine the relationship between students' achievement goals, their use of learning strategies and their academic achievement. Multiple Hierarchical Regressions Analyses identified, as predicted, positive effects of mastery goals, including more use of learning strategies and hi...

  19. Major Targets for 2010

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ This year, the main targets we have set for economic and social development are: increasing GDP by approximately 8 percent, creating jobs for more than 9 million people, keeping the urban registered unemployment rate no higher than 4.6 percent, holding the rise in consumer prices to around 3 percent, and improving the balance of payments.

  20. Target chambers for gammashpere

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Falout, J.W.; Nardi, B.G. [and others

    1995-08-01

    One of our responsibilities for Gammasphere, was designing and constructing two target chambers and associated beamlines to be used with the spectrometer. The first chamber was used with the early implementation phase of Gammasphere, and consisted of two spun-Al hemispheres welded together giving a wall thickness of 0.063 inches and a diameter of 12 inches.

  1. Enhanced target factor analysis.

    Science.gov (United States)

    Rostami, Akram; Abdollahi, Hamid; Maeder, Marcel

    2016-03-10

    Target testing or target factor analysis, TFA, is a well-established soft analysis method. TFA answers the question whether an independent target test vector measured at the same wavelengths as the collection of spectra in a data matrix can be excluded as the spectrum of one of the components in the system under investigation. Essentially, TFA cannot positively prove that a particular test spectrum is the true spectrum of one of the components, it can, only reject a spectrum. However, TFA will not reject, or in other words TFA will accept, many spectra which cannot be component spectra. Enhanced Target Factor Analysis, ETFA addresses the above problem. Compared with traditional TFA, ETFA results in a significantly narrower range of positive results, i.e. the chance of a false positive test result is dramatically reduced. ETFA is based on feasibility testing as described in Refs. [16-19]. The method has been tested and validated with computer generated and real data sets. PMID:26893084

  2. Cancer immunotherapy targeting neoantigens.

    Science.gov (United States)

    Lu, Yong-Chen; Robbins, Paul F

    2016-02-01

    Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.

  3. ISOLDE back on target

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    Today, Friday 1 August, the ISOLDE installation, supplied by the beams of the PS Booster, restarted its physics programme. After a shutdown of almost a year and a half, there was a real buzz in the air as the first beam of protons hit the target of the first post-LS1 ISOLDE experiment.   One of the new target-handling robots installed by ISOLDE during LS1. Many improvements have been made to the ISOLDE installation during LS1. One of the main projects was the installation of new robots for handling the targets (see photo 1). “Our targets are bombarded by protons from the PS Booster’s beams and become very radioactive,” explains Maria Jose Garcia Borge, spokesperson for the ISOLDE collaboration. “They therefore need to be handled carefully, which is where the robots come in. The robots we had until now were already over 20 years old and were starting to suffer from the effects of radiation. So LS1 was a perfect opportunity to replace them with more moder...

  4. Achieving low latency and energy consumption by 5G TDD mode optimization

    DEFF Research Database (Denmark)

    Lähetkangas, Eeva; Pajukoski, Kari; Vihriälä, Jaakko;

    2014-01-01

    The target for a new 5G radio access technology is to support multi-Gbps and ms latency connectivity simultaneously at noticeably lower energy consumption and cost compared to the existing 4G technologies, such as LTE-Advanced. Extremely short air interface latency is required to achieve these re...

  5. Influence of Parenting Styles on the Adolescent Students' Academic Achievement in Kenyan Day Secondary Schools

    Science.gov (United States)

    Odongo, Alice Atieno; Aloka, Peter J. O.; Raburu, Pamela

    2016-01-01

    The present study sought to establish the influence of parenting styles on adolescent academic achievement in day secondary schools in North Rachuonyo Sub-County, Kenya. Baumrind's theory of parenting style informed the study. The Concurrent Triangulation Design was used. The target population comprised 2409 day secondary students registered for…

  6. Refugee Children in South Africa: Access and Challenges to Achieving Universal Primary Education

    Science.gov (United States)

    Meda, L.; Sookrajh, R.; Maharaj, B.

    2012-01-01

    This paper questions whether the second Millennium Development Goal of achieving universal primary education targets by 2015 for all children to complete a full course of primary schooling, can be realised. A key contention of this paper is that this forecast is far-fetched when we take into cognizance refugee children's accessibility to…

  7. Impact of Discussion on Peer Evaluations: Perceptions of Low Achievement and Effort

    Science.gov (United States)

    Huenecke, Todd M.; Waas, Gregory A.

    2011-01-01

    The authors placed 5th-grade students into small groups of 3 in order to examine the impact of group discussion and displayed effort on children's evaluations of a low-achieving peer. Low effort by a target peer resulted in negative evaluations across attributional, affective, help-giving, and social response dimensions. Children who participated…

  8. Impact of Attending Jump Start Literacy Camp on Reading Achievement among Third and Fourth Grade Students

    Science.gov (United States)

    Padgett, Carrie B.

    2010-01-01

    The Jump Start Literacy Camp was developed as a means to combat summer learning loss. The camp utilized high-energy activities to target phonemic awareness, phonics, vocabulary, fluency, and comprehension. This study examined the effects of the Jump Start Literacy Camp on reading achievement for rising third and fourth grade students in an urban…

  9. Achieving Quality Education in Ghana: The Spotlight on Primary Education within the Kumasi Metropolis

    Science.gov (United States)

    Boakye-Amponsah, Abraham; Enninful, Ebenezer Kofi; Anin, Emmanuel Kwabena; Vanderpuye, Patience

    2015-01-01

    Background: Ghana being a member of the United Nations, committed to the Universal Primary Education initiative in 2000 and has since implemented series of educational reforms to meet the target for the Millennium Development Goal (MDG) 2. Despite the numerous government interventions to achieve the MDG 2, many children in Ghana have been denied…

  10. Academic Culture, Business Culture, and Measuring Achievement Differences: Internal Auditing Views

    Science.gov (United States)

    Roth, Benjamin S.

    2012-01-01

    This study explored whether university internal audit directors' views of culture and measuring achievement differences between their institutions and a business were related to how they viewed internal auditing priorities and uses. The Carnegie Classification system's 283 Doctorate-granting Universities were the target population.…

  11. Examining the Impact of Leadership Style and School Climate on Student Achievement

    Science.gov (United States)

    Robinson, Tina

    2010-01-01

    The purpose of this quantitative study was to investigate whether or not leadership style and school climate are significant predictors of student achievement. The target population consisted of elementary and high school teachers from Virginia public schools who had taught under the leadership of their respective current principals for at least 4…

  12. Optimization Studies for ISOL Type High-Powered Targets

    Energy Technology Data Exchange (ETDEWEB)

    Remec, Igor [Oak Ridge National Laboratory; Ronningen, Reginald Martin [Michigan State University

    2013-09-24

    The research studied one-step and two-step Isotope Separation on Line (ISOL) targets for future radioactive beam facilities with high driver-beam power through advanced computer simulations. As a target material uranium carbide in the form of foils was used because of increasing demand for actinide targets in rare-isotope beam facilities and because such material was under development in ISAC at TRIUMF when this project started. Simulations of effusion were performed for one-step and two step targets and the effects of target dimensions and foil matrix were studied. Diffusion simulations were limited by availability of diffusion parameters for UCx material at reduced density; however, the viability of the combined diffusion?effusion simulation methodology was demonstrated and could be used to extract physical parameters such as diffusion coefficients and effusion delay times from experimental isotope release curves. Dissipation of the heat from the isotope-producing targets is the limiting factor for high-power beam operation both for the direct and two-step targets. Detailed target models were used to simulate proton beam interactions with the targets to obtain the fission rates and power deposition distributions, which were then applied in the heat transfer calculations to study the performance of the targets. Results indicate that a direct target, with specification matching ISAC TRIUMF target, could operate in 500-MeV proton beam at beam powers up to ~40 kW, producing ~8 1013 fission/s with maximum temperature in UCx below 2200 C. Targets with larger radius allow higher beam powers and fission rates. For the target radius in the range 9-mm to 30-mm the achievable fission rate increases almost linearly with target radius, however, the effusion delay time also increases linearly with target radius.

  13. Size-varying small target detection for infrared image processing

    Science.gov (United States)

    Li, Miao; Zhu, Ran; Long, Yunli; An, Wei; Zhou, Yiyu

    2015-10-01

    IRST (Infrared Search and Track) has been applied to many military or civil fields such as precise guidance, aerospace, early warning. As a key technique, small target detection based on infrared image plays an important role. However, infrared targets have their own characteristics, such as target size variation, which make the detection work quite difficult. In practical application, the target size may vary due to many reasons, such as optic angle of sensors, imaging distance, environment and so on. For conventional detection methods, it is difficult to detect such size-varying targets, especially when the backgrounds have strong clutters. This paper presents a novel method to detect size-varying infrared targets in a cluttered background. It is easy to find that the target region is salient in infrared images. It means that target region have a signature of discontinuity with its neighboring regions and concentrates in a relatively small region, which can be considered as a homogeneous compact region, and the background is consistent with its neighboring regions. Motivated by the saliency feature and gradient feature, we introduce minimum target intensity (MTI) to measure the dissimilarity between different scales, and use mean gradient to restrict the target scale in a reasonable range. They are integrated to be multiscale MTI filter. The proposed detection method is designed based on multiscale MTI filter. Firstly, salient region is got by morphological low-pass filtering, where the potential target exists in. Secondly, the candidate target regions are extracted by multiscale minimum target intensity filter, which can effectively give the optimal target size. At last, signal-to-clutter ratio (SCR) is used to segment targets, which is computed based on optimal scale of candidate targets. The experimental results indicate that the proposed method can achieve both higher detection precision and robustness in complex background.

  14. Tumor-Targeted Nanomedicines

    Science.gov (United States)

    ElBayoumi, Tamer A.; Torchilin, Vladimir P.

    2009-01-01

    Purpose The efficacy of drug delivery systems can be enhanced by making them target-specific via the attachment of various ligands. We attempted to enhance tumor accumulation and therapeutic effect of doxorubicin-loaded long-circulating PEGylated liposomes (Doxil®, ALZA Corp.) by coupling to their surface the anti-cancer monoclonal antibody 2C5 (mAb 2C5) with nuclesome (NS)-restricted activity, that can recognize the surface of various tumor but not normal cells and specifically targets pharmaceutical carriers to tumor cells in vitro and in vivo. Following earlier in vitro results with various cancer cell lines, the mAb 2C5-liposomes were studied in vivo vs. plain and non-specific IgG-liposomes. Experimental design Antibody coupling to Doxil® was performed via the “post-insertion” technique. Using 111In-labeled liposomes, the tissue biodistribution and pharmacokinetic profile were studied, as well as their accumulation in tumors in mice was followed by the whole-body γ-scintigraphic imaging. Therapeutic efficacy of mAb 2C5-targeted Doxil® vs. non-specific IgG-modified and original Doxil® controls was followed by registering live tumor growth and determining tumor weights upon mice sacrifice. Results mAb2C5 antibody-targeted liposomes demonstrate enhanced accumulation in tumors, and the in vivo therapeutic activity of the mAb 2C5-Doxil® treatment was found to be significantly superior, resulting in final tumor weights of only 25-40% compared to all Doxil® control treatments, when tested against the subcutaneous primary murine tumors of 4T1 and C26 and human PC3 tumor in nude mice. Conclusions Our results demonstrate the remarkable capability of 2C5-targeted Doxil® to specifically deliver its cargo into various tumors significantly increasing the efficacy of therapy. PMID:19276264

  15. An Architecture for Personal Achievement Evaluation System in An University By Applying Open Source ECM and Bi Software

    OpenAIRE

    Muslin Ridhrod; Taratip Suwannasart; Arthit Thongtak

    2014-01-01

    Personal achievement evaluation process is necessary to understand each employee’s abilities, competencies, and relative merits which are very important for an organization. The results of evaluation process are analyzed between achievement targets and actual achievement scores, which are collected and stored from many data sources and documents such as evaluation patterns, groups of person, and kinds of workload. Furthermore, for each evaluation period, flexible policies and procedures are n...

  16. Unions Target Foreign Firms

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    ACFTU aims to build trade unions at all foreign-funded companies in China by the end of 2009 All-China Federation of Trade Unions (ACFTU) held a press conference on December 24, 2008,reviewing the achievements of the national unionization campaign, which began in June the same year, for multinational companies in China.

  17. THE ROLE OF MARKETING IN HOTEL INDUSTRY : Six successful hotel units in Abuja and Jakobstad

    OpenAIRE

    Talabi, Juwon

    2015-01-01

    The hotel business is arguably the most lucrative business within the hospitality industry. This is proven by the astronomical growth rate of the industry. However, in the recent years, the industry has witnessed a high level of competitions which makes hotel owners and managers search for new ways of ensuring success in their business voyages by applying different strategies to yield high occupancy rate of their hotel rooms and concomitantly provides them with good returns on their investmen...

  18. Classification SAR targets with support vector machine

    Science.gov (United States)

    Cao, Lanying

    2007-02-01

    With the development of Synthetic Aperture Radar (SAR) technology, automatic target recognition (ATR) is becoming increasingly important. In this paper, we proposed a 3-class target classification system in SAR images. The system is based on invariant wavelet moments and support vector machine (SVM) algorithm. It is a two-stage approach. The first stage is to extract and select a small set of wavelet invariant moment features to indicate target images. The wavelet invariant moments take both advantages of the wavelet inherent property of multi-resolution analysis and moment invariants quality of invariant to translation, scaling changes and rotation. The second stage is classification of targets with SVM algorithm. SVM is based on the principle of structural risk minimization (SRM), which has been shown better than the principle of empirical risk minimization (ERM) which is used by many conventional networks. To test the performance and efficiency of the proposed method, we performed experiments on invariant wavelet moments, different kernel functions, 2-class identification, and 3-class identification. Test results show that wavelet invariant moments indicate the target effectively; linear kernel function achieves better results than other kernel functions, and SVM classification approach performs better than conventional nearest distance approach.

  19. Shift-invariant target in allocation problems.

    Science.gov (United States)

    Mandal, Saumen; Biswas, Atanu

    2014-07-10

    We provide a template for finding target allocation proportions in optimal allocation designs where the target will be invariant for both shifts in location and scale of the response distributions. One possible application of such target allocation proportions is to carry out a response-adaptive allocation. While most of the existing designs are invariant for any change in scale of the underlying distributions, they are not location invariant in most of the cases. First, we indicate this serious flaw in the existing literature and illustrate how this lack of location invariance makes the performance of the designs very poor in terms of allocation for any drastic change in location, such as the changes from degrees centigrade to degrees Fahrenheit. We illustrate that unless a target allocation is location invariant, it might lead to a completely irrelevant and useless target for allocation. Then we discuss how such location invariance can be achieved for general continuous responses. We illustrate the proposed method using some real clinical trial data. We also indicate the possible extension of the procedure for more than two treatments at hand and in the presence of covariates.

  20. Novel targeted agents for gastric cancer

    Directory of Open Access Journals (Sweden)

    Liu Lian

    2012-06-01

    Full Text Available Abstract Contemporary advancements have had little impact on the treatment of gastric cancer (GC, the world’s second highest cause of cancer death. Agents targeting human epidermal growth factor receptor mediated pathways have been a common topic of contemporary cancer research, including monoclonal antibodies (mAbs and receptor tyrosine kinase inhibitors (TKIs. Trastuzumab is the first target agent evidencing improvements in overall survival in HER2-positive (human epidermal growth factor receptor 2 gastric cancer patients. Agents targeting vascular epithelial growth factor (VEGF, mammalian target of rapamycin (mTOR, and other biological pathways are also undergoing clinical trials, with some marginally positive results. Effective targeted therapy requires patient selection based on predictive molecular biomarkers. Most phase III clinical trials are carried out without patient selection; therefore, it is hard to achieve personalized treatment and to monitor patient outcome individually. The trend for future clinical trials requires patient selection methods based on current understanding of GC biology with the application of biomarkers.

  1. Therapeutic targeting of replicative immortality.

    Science.gov (United States)

    Yaswen, Paul; MacKenzie, Karen L; Keith, W Nicol; Hentosh, Patricia; Rodier, Francis; Zhu, Jiyue; Firestone, Gary L; Matheu, Ander; Carnero, Amancio; Bilsland, Alan; Sundin, Tabetha; Honoki, Kanya; Fujii, Hiromasa; Georgakilas, Alexandros G; Amedei, Amedeo; Amin, Amr; Helferich, Bill; Boosani, Chandra S; Guha, Gunjan; Ciriolo, Maria Rosa; Chen, Sophie; Mohammed, Sulma I; Azmi, Asfar S; Bhakta, Dipita; Halicka, Dorota; Niccolai, Elena; Aquilano, Katia; Ashraf, S Salman; Nowsheen, Somaira; Yang, Xujuan

    2015-12-01

    One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and therapeutic resistance. Innate cellular mechanisms have evolved to regulate replicative potential as a hedge against malignant progression. When activated in the absence of normal terminal differentiation cues, these mechanisms can result in a state of persistent cytostasis. This state, termed "senescence," can be triggered by intrinsic cellular processes such as telomere dysfunction and oncogene expression, and by exogenous factors such as DNA damaging agents or oxidative environments. Despite differences in upstream signaling, senescence often involves convergent interdependent activation of tumor suppressors p53 and p16/pRB, but can be induced, albeit with reduced sensitivity, when these suppressors are compromised. Doses of conventional genotoxic drugs required to achieve cancer cell senescence are often much lower than doses required to achieve outright cell death. Additional therapies, such as those targeting cyclin dependent kinases or components of the PI3K signaling pathway, may induce senescence specifically in cancer cells by circumventing defects in tumor suppressor pathways or exploiting cancer cells' heightened requirements for telomerase. Such treatments sufficient to induce cancer cell senescence could provide increased patient survival with fewer and less severe side effects than conventional cytotoxic regimens. This positive aspect is countered by important caveats regarding senescence reversibility, genomic instability, and paracrine effects that may increase heterogeneity and adaptive resistance of surviving cancer cells. Nevertheless, agents that effectively disrupt replicative immortality will likely be valuable components of new combinatorial approaches to cancer therapy. PMID:25869441

  2. The role of marine reserves in achieving sustainable fisheries.

    Science.gov (United States)

    Roberts, Callum M; Hawkins, Julie P; Gell, Fiona R

    2005-01-29

    Many fishery management tools currently in use have conservation value. They are designed to maintain stocks of commercially important species above target levels. However, their limitations are evident from continuing declines in fish stocks throughout the world. We make the case that to reverse fishery declines, safeguard marine life and sustain ecosystem processes, extensive marine reserves that are off limits to fishing must become part of the management strategy. Marine reserves should be incorporated into modern fishery management because they can achieve many things that conventional tools cannot. Only complete and permanent protection from fishing can protect the most sensitive habitats and vulnerable species. Only reserves will allow the development of natural, extended age structures of target species, maintain their genetic variability and prevent deleterious evolutionary change from the effects of fishing. Species with natural age structures will sustain higher rates of reproduction and will be more resilient to environmental variability. Higher stock levels maintained by reserves will provide insurance against management failure, including risk-prone quota setting, provided the broader conservation role of reserves is firmly established and legislatively protected. Fishery management measures outside protected areas are necessary to complement the protection offered by marine reserves, but cannot substitute for it.

  3. Stellar Chemical Abundances: In Pursuit of the Highest Achievable Precision

    CERN Document Server

    Bedell, M; Bean, J; Ramirez, I; Leite, P; Asplund, M

    2014-01-01

    The achievable level of precision on photospheric abundances of stars is a major limiting factor on investigations of exoplanet host star characteristics, the chemical histories of star clusters, and the evolution of the Milky Way and other galaxies. While model-induced errors can be minimized through the differential analysis of spectrally similar stars, the maximum achievable precision of this technique has been debated. As a test, we derive differential abundances of 19 elements from high-quality asteroid-reflected solar spectra taken using a variety of instruments and conditions. We treat the solar spectra as being from unknown stars and use the resulting differential abundances, which are expected to be zero, as a diagnostic of the error in our measurements. Our results indicate that the relative resolution of the target and reference spectra is a major consideration, with use of different instruments to obtain the two spectra leading to errors up to 0.04 dex. Use of the same instrument at different epoc...

  4. Stellar chemical abundances: in pursuit of the highest achievable precision

    Energy Technology Data Exchange (ETDEWEB)

    Bedell, Megan; Bean, Jacob L. [Department of Astronomy and Astrophysics, University of Chicago, 5640 S. Ellis Avenue, Chicago, IL 60637 (United States); Meléndez, Jorge; Leite, Paulo [Departamento de Astronomia do IAG/USP, Universidade de São Paulo, Rua do Matão 1226, Cidade Universitária, São Paulo, SP 05508-900 (Brazil); Ramírez, Ivan [McDonald Observatory and Department of Astronomy, University of Texas at Austin, Austin, TX 78712-1206 (United States); Asplund, Martin, E-mail: mbedell@oddjob.uchicago.edu [Research School of Astronomy and Astrophysics, The Australian National University, Cotter Road, Weston, ACT 2611 (Australia)

    2014-11-01

    The achievable level of precision on photospheric abundances of stars is a major limiting factor on investigations of exoplanet host star characteristics, the chemical histories of star clusters, and the evolution of the Milky Way and other galaxies. While model-induced errors can be minimized through the differential analysis of spectrally similar stars, the maximum achievable precision of this technique has been debated. As a test, we derive differential abundances of 19 elements from high-quality asteroid-reflected solar spectra taken using a variety of instruments and conditions. We treat the solar spectra as being from unknown stars and use the resulting differential abundances, which are expected to be zero, as a diagnostic of the error in our measurements. Our results indicate that the relative resolution of the target and reference spectra is a major consideration, with use of different instruments to obtain the two spectra leading to errors up to 0.04 dex. Use of the same instrument at different epochs for the two spectra has a much smaller effect (∼0.007 dex). The asteroid used to obtain the solar standard also has a negligible effect (∼0.006 dex). Assuming that systematic errors from the stellar model atmospheres have been minimized, as in the case of solar twins, we confirm that differential chemical abundances can be obtained at sub-0.01 dex precision with due care in the observations, data reduction, and abundance analysis.

  5. Achievements of element technology development for breeding blanket

    International Nuclear Information System (INIS)

    Japan Atomic Energy Research Institute (JAERI) has been performing the development of breeding blanket for fusion power plant, as a leading institute of the development of solid breeder blankets, according to the long-term R and D program of the blanket development established by the Fusion Council of Japan in 1999. This report is an overview of development plan, achievements of element technology development and future prospect and plan of the development of the solid breeding blanket in JAERI. In this report, the mission of the blanket development activity in JAERI, key issues and roadmap of the blanket development have been clarified. Then, achievements of the element technology development were summarized and showed that the development has progressed to enter the engineering testing phase. The specific development target and plan were clarified with bright prospect. Realization of the engineering test phase R and D and completion of ITER test blanket module testing program, with universities/NIFS cooperation, are most important steps in the development of breeding blanket of fusion power demonstration plant. (author)

  6. Academic achievement of children of divorced parents.

    Science.gov (United States)

    Cherian, V I

    1989-04-01

    This study investigated the academic achievement of 242 pupils whose parents were divorced and 713 pupils whose parents were neither divorced nor separated. The subjects were in the age range of 13 to 17 yr., with a mean age of 15.6 yr. and they were chosen at random from the total Standard 7 population of Transkei, South Africa. A questionnaire was administered to 1,021 pupils to identify the children of parents divorced or separated and neither divorced nor separated. Analysis of variance indicated that the academic achievement of children whose parents were divorced or separated was significantly lower than that of the children whose parents were neither divorced nor separated.

  7. Molecular nuclear imaging for targeting and trafficking

    International Nuclear Information System (INIS)

    Noninvasive molecular targeting in living subjects is highly demanded for better understanding of such diverse topics as the efficient delivery of drugs, genes, or radionuclides for the diagnosis or treatment of diseases. Progress in molecular biology, genetic engineering and polymer chemistry provides various tools to target molecules and cells in vivo. We used chitosan as a polymer, and 99mTc as a radionuclide. We developed 99mTc-galactosylated chitosan to target asialoglycoprotein receptors for nuclear imaging. We also developed 99mTc-HYNIC-chitosan-transferrin to target inflammatory cells, which was more effective than 67Ga-citrate for imaging inflammatory lesions. For an effective delivery of molecules, a longer circulation time is needed. We found that around 10% PEGylation was most effective to prolong the circulation time of liposomes for nuclear imaging of 99mTc-HMPAO-labeled liposomes in rats. Using various characteristics of molecules, we can deliver drugs into targets more effectively. We found that 99mTc-labeled biodegradable pullulan-derivatives are retained in tumor tissue in response to extracellular ion-strength. For the trafficking of various cells or bacteria in an intact animal, we used optical imaging techniques or radiolabeled cells. We monitored tumor-targeting bacteria by bioluminescent imaging techniques, dentritic cells by radiolabeling and neuronal stem cells by sodium-iodide symporter reporter gene imaging. In summary, we introduced recent achievements of molecular nuclear imaging technologies in targeting receptors for hepatocyte or inflammatory cells and in trafficking bacterial, immune and stem cells using molecular nuclear imaging techniques

  8. The Link between Musical Achievement and Academic Achievement of Young Children

    Science.gov (United States)

    Costley, Kevin C.

    2011-01-01

    During the twentieth century it has been theorized that there is a link between musical achievement and academic achievement of young children. In support of this controversial view, many educators and music specialists promote the relationship between, parent, teacher, and child. The theory is: with cooperative learning experiences in the study…

  9. Science Achievement for All: Improving Science Performance and Closing Achievement Gaps

    Science.gov (United States)

    Jackson, Julie K.; Ash, Gwynne

    2012-01-01

    This article addresses the serious and growing need to improve science instruction and science achievement for all students. We will describe the results of a 3-year study that transformed science instruction and student achievement at two high-poverty ethnically diverse public elementary schools in Texas. The school-wide intervention included…

  10. Predicting Mathematics Achievement by Motivation and Self-Efficacy across Gender and Achievement Levels

    Science.gov (United States)

    Sartawi, AbdelAziz; Alsawaie, Othman N.; Dodeen, Hamzeh; Tibi, Sana; Alghazo, Iman M.

    2012-01-01

    This study investigated the extent to which self-efficacy and motivation served as a predictor for mathematics achievement of fifth grade students in United Arab Emirates (UAE) across gender and achievement levels. Self-efficacy was measured by two scales, which differed in levels of specificity--Category Specific and Task Specific. Motivation was…

  11. Formidable achievement through determination and pragmatism

    International Nuclear Information System (INIS)

    Anglo American Corporation's former chief consulting metallurgist Ewen Pinkney has a remarkable record of achievement in mining metallurgy and chemical engineering at mines all over Southern Africa despite the fact that he could not afford a university education. Just one feature of his career was the leading role he played in the establishment of the country's first big uranium plants. This as well as other features of his career are discussed

  12. Does High School Homework Increase Academic Achievement?

    OpenAIRE

    Kalenkoski, Charlene Marie; Wulff Pabilonia, Sabrina

    2014-01-01

    Although previous research has shown that homework improves students' academic achievement, the majority of these studies use data on students' homework time from retrospective questionnaires, which are less accurate than time-diary data. However, most time-diary data sets do not contain outcome measures, and thus are limited in the questions they can answer. One data set that does have both time-diary and outcome information is the combined Child Development Supplement (CDS) and the Transiti...

  13. Quantum gravity phenomenology. Achievements and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Liberati, S. [International School for Advanced Study (SISSA), Trieste (Italy); INFN, Sezione di Trieste (Italy); Maccione, L. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-05-15

    Motivated by scenarios of quantum gravity, Planck-suppressed deviations from Lorentz invariance are expected at observable energies. Ultra-High-Energy Cosmic Rays, the most energetic particles ever observed in nature, yielded in the last two years strong constraints on deviations suppressed by O(E{sup 2}/M{sup 2}{sub Pl}) and also, for the first time, on space-time foam, stringy inspired models of quantum gravity. We review the most important achievements and discuss future outlooks. (orig.)

  14. Parental Economic Hardship and Children's Achievement Orientations*

    OpenAIRE

    Mortimer, Jeylan T.; Zhang, Frank Lei; Hussemann, Jeanette; Wu, Chen-Yu

    2014-01-01

    While children’s orientations to achievement are strong predictors of attainments, little is known about how parental economic hardship during recessionary times influences children’s orientations to their futures. The Youth Development Study has followed a community sample of young people in St Paul, Minnesota from mid-adolescence through their mid-thirties with near-annual surveys, and has recently begun surveying the children of this cohort. Using linked parent and child data, the present ...

  15. Using Robotics to Achieve Meaningfully Engaged Learning

    OpenAIRE

    Caldwell, Rebecca; Jones, Elva

    2011-01-01

    There has been a significant decline in the number of college students choosing majors in computer science or technology related fields. Additionally, within the United States, there is an achievement gap between under-represented minority students and majority students at a time when underrepresented groups are becoming an increasing proportion of the national labor force. This reluctance to study Science, Technology, Engineering, and Mathematics (STEM) disciplines must be confronted and ch...

  16. Achievements of sustainable manufacturing by machining

    OpenAIRE

    J. Kopac

    2009-01-01

    Purpose: Manufacturing industry is under increasing pressure of global competition, stricter environmental legislation and supply-chain demand for improved sustainability performance. The latter can be achieved through changes in products, processes and systems which are related to the sustainability issues. Sustainability in manufacturing is an appropriate approach; however it is still unified to a higher production rate and benefit. To encounter this problem academic, scientific, cultural a...

  17. Home care 2012: Achievements, challenges, opportunities

    OpenAIRE

    Mackenzie, Isobel

    2012-01-01

    This video clip comprises the Keynote Address: “Home care 2012: Achievements, challenges, opportunities” held at the 21st Annual John K. Friesen Conference, "Innovations in Home Care: A Public Policy Perspective," MAY 16-17, 2012, Vancouver, BC. Presented by Isobel Mackenzie, Chief Executive Officer, Beacon Community Services. It is well known that jurisdictions with more comprehensive and integrated home care delivery systems are able to extend independent living for older people for...

  18. ACHIEVING SUSTAINABLE TOURISM THROUGH CUSTOMER SATISFACTION

    OpenAIRE

    Ispas Roxana,; Marinescu Roxana Cristina

    2012-01-01

    In tourism, hotels play an important role and contribute to the economic growth in cities and other places endowed with attractions which are universally recognized. Two elements are essential in the tourism industry system: product quality and human resources. In terms of quality of the hotel services, that is the one that allows to the tourist enterprise to own a competitive advantage, gain competitive differentiation and reputation among customers by achieving a high degree of customer s...

  19. Academic achievement: Intelligence, regulatory, and cognitive predictors.

    Directory of Open Access Journals (Sweden)

    Morosanova V.I.

    2015-07-01

    Full Text Available Using the results of two empirical studies (with different samples and academic subjects, our research was aimed at discovering the significant role of conscious self-regulation, intelligence, and cognitive features in predicting optimal academic achievement. The sample consisted of 406 students (aged 14-16 in the 8th to 11th grades of the Russian formal education system. Conscious self-regulation together with intelligence and cognitive abilities was determined to be a significant predictor of academic success. The Study 1 results revealed that the general level of self-regulation of learning activity and certain regulatory features were significant predictors of different types of mathematical achievements: academic grades, scores on exams, mathematical fluency, as well as solving logical mathematical problems and equations. The present study is the first to show the mediating role of self-regulation in relation to intelligence, cognitive features, and academic success. Study 2 found evidence that conscious self-regulation and intelligence can predict academic achievement in the humanities, mathematics, and natural sciences... At the same time, this determination has its peculiarities in particular variables of intelligence and certain self-regulation processes depending on the substantive characteristics of the academic subjects. Regression models of academic success in the humanities identified verbal intelligence associated with vocabulary as highly significant and a definitive requirement for success in these subjects. Study 1 and Study 2 showed that the only significant predictors of success in algebra and geometry were quantitative- relations intelligence and spatial intelligence. The implications of these findings for investigating predictors of academic achievement are discussed.

  20. Control theory: history, mathematical achievements and perspectives

    OpenAIRE

    Fernández Cara, Enrique; Zuazua Iriondo, Enrique

    2003-01-01

    These notes are devoted to present some of the mathematical milestones of Control Theory. To do that, we first overview its origins and some of the main mathematical achievements. Then, we discuss the main domains of Sciences and Technologies where Control Theory arises and applies. This forces us to address modelling issues and to distinguish between the two main control theoretical approaches, controllability and optimal control, discussing the advantages and drawbacks of ...

  1. Hungary's banking sector: achievements and challenges

    OpenAIRE

    Várhegyi, Éva

    2002-01-01

    Hungary is generally considered one of the best performing transition countries, having been successful in achieving macroeconomic stabilisation and in creating a market-driven economic system (see, for instance, Fischer and Sahay, 2000; and Weder, 2001). In terms of financial sector reforms, the country is also considered in the advanced league (Bokros, 2001). While we agree to this assessment, it is also true that the degree of monetisation and bank intermediation in the Hungarian economy i...

  2. Evaluation of Project Achievements in VOMARE -project

    OpenAIRE

    Kokkarinen, Eeva

    2011-01-01

    The purpose of the thesis is to study the achievements of VOMARE –project from the Finnish Lifeboat Institutions perspective. The organisation is a roof organisation for voluntary maritime rescue operation in Finland. The Finnish Lifeboat Institution is a lead partner in VOMARE –project which is EU funded project and the aim of the project is to start voluntary rescue operations in Estonia. The theoretical part of the work is divided into two main categories; project management and planni...

  3. Academic achievement: Intelligence, regulatory, and cognitive predictors.

    OpenAIRE

    Morosanova V.I.; Fomina T.G.; Bondarenko I.N.

    2015-01-01

    Using the results of two empirical studies (with different samples and academic subjects), our research was aimed at discovering the significant role of conscious self-regulation, intelligence, and cognitive features in predicting optimal academic achievement. The sample consisted of 406 students (aged 14-16) in the 8th to 11th grades of the Russian formal education system. Conscious self-regulation together with intelligence and cognitive abilities was determined to be a significant predicto...

  4. Academic achievement: intelligence, regulatory, and cognitive predictors

    OpenAIRE

    MOROSANOVA VARVARA I.; FOMINA TATIANA G.; BONDARENKO IRINA N.

    2015-01-01

    Using the results of two empirical studies (with different samples and academic subjects), our research was aimed at discovering the significant role of conscious self-regulation, intelligence, and cognitive features in predicting optimal academic achievement. The sample consisted of 406 students (aged 14-16) in the 8th to 11th grades of the Russian formal education system. Conscious self-regulation together with intelligence and cognitive abilities was determined to be a significant predicto...

  5. Effective Factors in Achieving Sustainable Agriculture

    Directory of Open Access Journals (Sweden)

    Tahereh Sharghi

    2010-01-01

    Full Text Available Problem statement: The indiscriminate use of chemical inputs led to severe degradation of resources in Iran. Therefore, considering the increasing population and growing demand of agricultural products, it seems necessary to achieve a sustainable agriculture. In this study, sustainable agriculture refers to a kind of agriculture which is ecologically appropriate, economically justifiable, and socially desirable. Approach: There were two objectives for this study .The first objective of this study was to identify the effective factors in achieving sustainable agriculture. The second objective was to categorize the effective factors in achieving sustainable agriculture. In this study the Delphi technique has been used. Sustainable agriculture expert researchers of statistical and related issues were 56 scholars selected from the experts in the research centers of Tehran and Yazd provinces. The instruments used in data collection were three series of questionnaires sent to the researchers via email, fax and mail. Results: Findings have shown that the researchers have identified effective factors in achieving sustainable agriculture in Iran as the sections of Infrastructure, policy-making, economy, society, participation, research, extension and education. From the 35 factors exposed to the researchers, the factors of attainment of researches related to sustainable agriculture by agricultural research institutions in Iran, Interaction and participation of researchers, extension educators, farmers and policy-makers of sustainable agriculture, attempt to give priority to those who are the most appropriate from the standpoint of practically creating interactive, logical as well as flexible planning system between different sections dealing with sustainable agriculture have gained the agreement of 100% researchers. Conclusion: The important conclusion is that the communication between extension, farmers and policymaker should be strengthened. So

  6. Quantum gravity phenomenology. Achievements and challenges

    International Nuclear Information System (INIS)

    Motivated by scenarios of quantum gravity, Planck-suppressed deviations from Lorentz invariance are expected at observable energies. Ultra-High-Energy Cosmic Rays, the most energetic particles ever observed in nature, yielded in the last two years strong constraints on deviations suppressed by O(E2/M2Pl) and also, for the first time, on space-time foam, stringy inspired models of quantum gravity. We review the most important achievements and discuss future outlooks. (orig.)

  7. Achieving Supply Chain Integration within Construction Industry

    OpenAIRE

    Peter McDermotti; Malik Khalfan

    2012-01-01

    The main driver behind the adoption of supply chain management (SCM) philosophy into the construction industry was the successes within other industry sectors. SCM can be defined as network of different organisations, linked upstream and downstream in a chain, aiming to produce quality and value in the services and products for the end consumers through integrated processes and activities. In order to achieve the optimised level of integration of the whole supply chain, the industry has respo...

  8. Achievement of Total Quality Is Impossibility

    OpenAIRE

    Xiaohang Wu; Yafei Wang

    2009-01-01

    In the manufacturing industry, product quality has become a key factor in determining a firm’s success or failure in the global marketplace. Advanced, highly reliable manufacturing methods have made it possible to achieve very high standards of product quality. As a result, more and more firms are making product quality a keystone of their competitive strategy. However, the improvement of production quality is a long-term commitment to continuous improvement in every aspect of the production ...

  9. Important cellular targets for antimicrobial photodynamic therapy.

    Science.gov (United States)

    Awad, Mariam M; Tovmasyan, Artak; Craik, James D; Batinic-Haberle, Ines; Benov, Ludmil T

    2016-09-01

    The persistent problem of antibiotic resistance has created a strong demand for new methods for therapy and disinfection. Photodynamic inactivation (PDI) of microbes has demonstrated promising results for eradication of antibiotic-resistant strains. PDI is based on the use of a photosensitive compound (photosensitizer, PS), which upon illumination with visible light generates reactive species capable of damaging and killing microorganisms. Since photogenerated reactive species are short lived, damage is limited to close proximity of the PS. It is reasonable to expect that the larger the number of damaged targets is and the greater their variety is, the higher the efficiency of PDI is and the lower the chances for development of resistance are. Exact molecular mechanisms and specific targets whose damage is essential for microbial inactivation have not been unequivocally established. Two main cellular components, DNA and plasma membrane, are regarded as the most important PDI targets. Using Zn porphyrin-based PSs and Escherichia coli as a model Gram-negative microorganism, we demonstrate that efficient photoinactivation of bacteria can be achieved without detectable DNA modification. Among the cellular components which are modified early during illumination and constitute key PDI targets are cytosolic enzymes, membrane-bound protein complexes, and the plasma membrane. As a result, membrane barrier function is lost, and energy and reducing equivalent production is disrupted, which in turn compromises cell defense mechanisms, thus augmenting the photoinduced oxidative injury. In conclusion, high PDI antimicrobial effectiveness does not necessarily require impairment of a specific critical cellular component and can be achieved by inducing damage to multiple cellular targets. PMID:27221289

  10. Parallel algorithm for target recognition using a multiclass hash database

    Science.gov (United States)

    Uddin, Mosleh; Myler, Harley R.

    1998-07-01

    A method for recognition of unknown targets using large databases of model targets is discussed. Our approach is based on parallel processing of multi-class hash databases that are generated off-line. A geometric hashing technique is used on feature points of model targets to create each class database. Bit level coding is then performed to represent the models in an image format. Parallelism is achieved during the recognition phase. Feature points of an unknown target are passed to parallel processors each accessing an individual class database. Each processor reads a particular class of hash data base and indexes feature points of the unknown target. A simple voting technique is applied to determine the best match model with the unknown. The paper discusses our technique and the results from testing with unknown FLIR targets.

  11. Are Reductions in Population Sodium Intake Achievable?

    Directory of Open Access Journals (Sweden)

    Jessica L. Levings

    2014-10-01

    Full Text Available The vast majority of Americans consume too much sodium, primarily from packaged and restaurant foods. The evidence linking sodium intake with direct health outcomes indicates a positive relationship between higher levels of sodium intake and cardiovascular disease risk, consistent with the relationship between sodium intake and blood pressure. Despite communication and educational efforts focused on lowering sodium intake over the last three decades data suggest average US sodium intake has remained remarkably elevated, leading some to argue that current sodium guidelines are unattainable. The IOM in 2010 recommended gradual reductions in the sodium content of packaged and restaurant foods as a primary strategy to reduce US sodium intake, and research since that time suggests gradual, downward shifts in mean population sodium intake are achievable and can move the population toward current sodium intake guidelines. The current paper reviews recent evidence indicating: (1 significant reductions in mean population sodium intake can be achieved with gradual sodium reduction in the food supply, (2 gradual sodium reduction in certain cases can be achieved without a noticeable change in taste or consumption of specific products, and (3 lowering mean population sodium intake can move us toward meeting the current individual guidelines for sodium intake.

  12. DPAL: historical perspective and summary of achievements

    Science.gov (United States)

    Zhdanov, B. V.; Knize, R. J.

    2013-10-01

    Alkali vapor lasers are under extensive research and development during the past decade because of their potential for scaling to high powers while maintaining a good beam quality. Also, a possibility of using efficient diode lasers for pumping alkali vapor promises high total wall plug efficiency for a Diode Pumped Alkali Laser (DPAL). Since the first DPAL demonstration with output power of 130 mW in 20051, a significant progress in this field was achieved. The output power of about 1 kW in continuous wave (CW) operation with optical efficiency close to 50% was recently demonstrated for a Cs DPAL2. Also, the DPALs based on other alkali metals (Rubidium and Potassium) were demonstrated3,4 . In spite of these significant achievements, there are still several problems in DPAL power scaling exist that must be addressed. Among them are the thermal5 and photoionization6 issues that become important even at power level about several tens of watts. In this paper we present a historical review of the alkali laser research and development, discuss the most important achievements and future perspectives in this field of research.

  13. [Affiliative achievement motivation and non-affiliative achievement motivation of female students].

    Science.gov (United States)

    Doi, K

    1988-02-01

    The purpose of this study was to investigate the two dimensional theory of achievement motivation (Doi, 1982) in female students. Doi's motivation scale were administered to 81 female university students, 58 female students of school of nursing and 77 female students of school of English Language, and the Yatabe-Guilford personality inventory was also administered to the first and the second groups. Affiliative achievement motivation and non-affiliative achievement motivation were extracted by principal component analyses and canonical correlation analyses. Non-affiliative achievement motivation was found to be related to personality type: emotional instability and introversion. These findings differ from achievement motivation concepts (Murray, 1938; McClelland, Atkinson, Clark, & Lowell, 1953), that include emotional stability and extraversion.

  14. Polarization discrimination between repeater false-target and radar target

    Institute of Scientific and Technical Information of China (English)

    SHI LongFei; WANG XueSong; XIAO ShunPing

    2009-01-01

    High fidelity repeater false-target badly affects a radar system's detecting, tracking, and data processing. It is an available approach of confronting false-target for radar that discriminates firstly and then eliminates. Whereas for the technique progress about the repeater false-target jam, it is more and more difficult to discriminate this jam in the time-domain, frequency-domain, or space-domain. The technique using polarization information to discriminate the target and false-target is discussed in this paper. With the difference that false-target signal vector's polarization ratio is fixed and target echo signal vector's polarization ratio is variational along with radar transmission signal's polarization, we transform the discrimination problem to beeline distinguish problem in the 2-dim complex space. The distributing characteristic expression of the false-target discrimination statistic is constructed, with which the discrimination ratio of false-target is analyzed. For the target case, the decomposed model of target scattering matrix and the concept of distinguish quantity are proposed. Then, the discrimination ratio of target can be forecasted according to target distinguish quantity. Thus, the performance of discrimination method has been analyzed integrally. The simulation results demonstrate the method in this paper is effective on the discrimination of target and false-target.

  15. Achieving energy efficiency through behaviour change: what does it take?

    Energy Technology Data Exchange (ETDEWEB)

    Barbu, A.-D. [European Environment Agency (EEA), Copenhagen (Denmark); Griffiths, N.; Morton, G. [Ricardo-AEA (United Kingdom)

    2013-04-15

    On October 2012, the European Union adopted the Energy Efficiency Directive in reaction to the fact that EU Member States were not on track to reduce primary energy consumption by 20 % by 2020. The implementation of this directive, and other policies that have been adopted in recent years, will require a change in consumer behaviour and energy consumption practices. Within this context, and related to on-going debates on the same subject, a new European Environment Agency (EEA) report argues that correctly navigating the interface between policymaking and human behaviour is key to achieving sustained reductions in energy consumption. As such, the report provides timely and reliable information and analysis to those involved in designing policy measures to reduce energy consumption which target the end consumer. A growing body of evidence in academic literature demonstrates that there is potential for energy savings due to measures targeting behaviour. There is, however, one issue that has not been covered by previous studies, and which the EEA report directly addresses, namely the distinction between consumer behaviour and consumption practices. Most recent academic literature argues that it is the consumption practices themselves that need careful scrutiny as they tend to lock consumers into patterns that are more and more energy intensive and they involve a wide range of actors. From the energy efficiency policy design perspective, this is relevant because these actors need to be involved from the outset of the policy process. The report also argues that a whole range of changes need to take place in the way energy markets function and are regulated in order to enable the consumer to actively engage with these markets. The report however does not include a discussion on the socio-economic implications of these structural changes. During 2013, the EEA will launch a survey via social media and its own website to follow up on conclusions of the report. The aim will

  16. Evolution with Drifting Targets

    CERN Document Server

    Kanade, Varun; Vaughan, Jennifer Wortman

    2010-01-01

    We consider the question of the stability of evolutionary algorithms to gradual changes, or drift, in the target concept. We define an algorithm to be resistant to drift if, for some inverse polynomial drift rate in the target function, it converges to accuracy 1 -- \\epsilon , with polynomial resources, and then stays within that accuracy indefinitely, except with probability \\epsilon , at any one time. We show that every evolution algorithm, in the sense of Valiant (2007; 2009), can be converted using the Correlational Query technique of Feldman (2008), into such a drift resistant algorithm. For certain evolutionary algorithms, such as for Boolean conjunctions, we give bounds on the rates of drift that they can resist. We develop some new evolution algorithms that are resistant to significant drift. In particular, we give an algorithm for evolving linear separators over the spherically symmetric distribution that is resistant to a drift rate of O(\\epsilon /n), and another algorithm over the more general prod...

  17. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    Hill, Amanda Louise; Leinikka Dall, Ole; Andersen, Frits M.

    2014-01-01

    the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...... will need to make efforts to recover all recyclable fractions, and that the increased recycling efforts of only selected municipalities will not be sufficient to reach the target.......Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22...

  18. Physics of polarized targets

    CERN Document Server

    Niinikoski, Tapio

    2014-01-01

    For developing, building and operating solid polarized targets we need to understand several fields of physics that have seen sub stantial advances during the last 50 years. W e shall briefly review a selection of those that are important today. These are: 1) quantum statistical methods to describe saturation and relaxation in magnetic resonance; 2) equal spin temperature model for dy namic nuclear polarization; 3 ) weak saturation during NMR polarization measurement; 4 ) refrigeration using the quantum fluid properties of helium isotopes. These, combined with superconducting magnet technologies, permit today to reach nearly complete pola rization of almost any nuclear spins. Targets can be operated in frozen spin mode in rather low and inhomogeneous field of any orientation, and in DNP mode in beams of high intensity. Beyond such experiments of nuclear and particle physics, applications a re also emerging in macromolecular chemistry and in magnetic resonance imaging. This talk is a tribute to Michel Borghini...

  19. Gene Targeting in Neuroendocrinology.

    Science.gov (United States)

    Candlish, Michael; De Angelis, Roberto; Götz, Viktoria; Boehm, Ulrich

    2015-09-20

    Research in neuroendocrinology faces particular challenges due to the complex interactions between cells in the hypothalamus, in the pituitary gland and in peripheral tissues. Within the hypothalamus alone, attempting to target a specific neuronal cell type can be problematic due to the heterogeneous nature and level of cellular diversity of hypothalamic nuclei. Because of the inherent complexity of the reproductive axis, the use of animal models and in vivo experiments are often a prerequisite in reproductive neuroendocrinology. The advent of targeted genetic modifications, particularly in mice, has opened new avenues of neuroendocrine research. Within this review, we evaluate various mouse models used in reproductive neuroendocrinology and discuss the different approaches to generate genetically modified mice, along with their inherent advantages and disadvantages. We also discuss a variety of versatile genetic tools with a focus on their potential use in reproductive neuroendocrinology.

  20. Targeting fragile X

    OpenAIRE

    Gantois, Ilse; Kooy, R. Frank

    2002-01-01

    Ten years after the identification of the gene responsible for fragile X syndrome, recent studies have revealed a list of mRNAs bound by the fragile X gene product and have identified specific sequences required for the interaction between the fragile X protein and its targets. These results are a breakthrough in understanding why absence of the fragile X protein leads to mental retardation.

  1. Follicular penetration and targeting.

    Science.gov (United States)

    Lademann, Jürgen; Otberg, Nina; Jacobi, Ute; Hoffman, Robert M; Blume-Peytavi, Ulrike

    2005-12-01

    In the past, intercellular penetration was assumed to be the most important penetration pathway of topically applied substances. First hints that follicular penetration needs to be taken into consideration were confirmed by recent investigations, presented during the workshop "Follicular Penetration and Targeting" at the 4th Intercontinental Meeting of Hair Research Societies", in Berlin 2004. Hair follicles represent an efficient reservoir for the penetration of topically applied substances with subsequent targeting of distinct cell populations, e.g., nestin-expressing follicular bulge cells. The volume of this reservoir can be determined by differential stripping technology. The follicular penetration processes are significantly influenced by the state of the follicular infundibulum; recent experimental investigations could demonstrate that it is essential to distinguish between open and closed hair follicles. Topically applied substances can only penetrate into open hair follicle. Knowledge of follicular penetration is of high clinical relevance for functional targeting of distinct follicular regions. Human hair follicles show a hair-cycle-dependent variation of the dense neuronal and vascular network. Moreover, during hair follicle cycling with initiation of anagen, newly formed vessels occur. Thus, the potential of nestin-expressing hair follicle stem cells to form neurons and blood vessels was investigated.

  2. Automatic target tracking on multi-resolution terrain

    Institute of Scientific and Technical Information of China (English)

    WAN Ming; ZHANG Wei; MURRAY Marie O.; KAUFMAN Arie

    2006-01-01

    We propose a high-performance path planning algorithm for automatic target tracking in the applications of real-time simulation and visualization of large-scale terrain datasets, with a large number of moving objects (such as vehicles) tracking multiple moving targets. By using a modified Dijkstra's algorithm, an optimal path between each vehicle-target pair over a weighted grid-presented terrain is computed and updated to eliminate the problem of local minima and losing of tracking. Then, a dynamic path re-planning strategy using multi-resolution representation of a dynamic updating region is proposed to achieve high-performance by trading-off precision for efficiency, while guaranteeing accuracy. Primary experimental results showed that our algorithm successfully achieved 10 to 96 frames per second interactive path-replanning rates during a terrain simulation scenario with 10 to 100 vehicles and multiple moving targets.

  3. Inflation targeting and core inflation

    OpenAIRE

    Julie Smith

    2005-01-01

    This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

  4. Multi-MW target station: Beam Window Issues and Transverse Film Target

    CERN Document Server

    Herrera-Martinez, A

    The analysis of the EURISOL-DS Multi_MW target precise geometry has proved that large fission yields can be achieved with a 4 MW, providing a technically feasible design to evacuate the power deposited in the liquid mercury. Different designs for the mercury flow have been proposed, which maintain its temperature below the boiling point with moderate flow speeds (maximum 4 m/s).

  5. EURISOL-DS MULTI-MW TARGET ISSUES: BEAM WINDOW AND TRANSVERSE FILM TARGET

    CERN Document Server

    Adonai Herrera-Martínez, Yacine Kadi

    The analysis of the EURISOL-DS Multi_MW target precise geometry (Fig.1) has proved that large fission yields can be achieved with a 4 MW, providing a technically feasible design to evacuate the power deposited in the liquid mercury. Different designs for the mercury flow have been proposed, which maintain its temperature below the boiling point with moderate flow speeds (maximum 4 m/s).

  6. Genetic improvement of tomato by targeted control of fruit softening

    KAUST Repository

    Uluisik, Selman

    2016-07-25

    Controlling the rate of softening to extend shelf life was a key target for researchers engineering genetically modified (GM) tomatoes in the 1990s, but only modest improvements were achieved. Hybrids grown nowadays contain \\'non-ripening mutations\\' that slow ripening and improve shelf life, but adversely affect flavor and color. We report substantial, targeted control of tomato softening, without affecting other aspects of ripening, by silencing a gene encoding a pectate lyase. © 2016 Nature America, Inc. All rights reserved.

  7. Bacteriophage-Derived Vectors for Targeted Cancer Gene Therapy

    OpenAIRE

    Md Zahidul Islam Pranjol; Amin Hajitou

    2015-01-01

    Cancer gene therapy expanded and reached its pinnacle in research in the last decade. Both viral and non-viral vectors have entered clinical trials, and significant successes have been achieved. However, a systemic administration of a vector, illustrating safe, efficient, and targeted gene delivery to solid tumors has proven to be a major challenge. In this review, we summarize the current progress and challenges in the targeted gene therapy of cancer. Moreover, we highlight the recent dev...

  8. The relationship between target quality and interference in sound zones

    OpenAIRE

    Baykaner, K; Coleman, P.; Mason, R.; Jackson, PJB; Francombe, J; Olik, M; Bech, S

    2015-01-01

    Sound zone systems aim to produce regions within a room where listeners may consume separate audio programs with minimal acoustical interference. Often, there is a trade-off between the acoustic contrast achieved between the zones, and the fidelity of the reproduced audio program (the target quality). An open question is whether reducing contrast (i.e. allowing greater interference) can improve target quality. The planarity control sound zoning method can be used to improve spatial reproducti...

  9. Achieving affordable housing through energy efficiency strategy

    International Nuclear Information System (INIS)

    Cooperation between public and private sector has achieved a remarkable widespread, in the Italian context, over the last two decades. Nevertheless, the increasing difficulty in accessing the capital market and the rising cost of funding sources, both noticeable over the past few years, led to a slowdown of Public–Private Partnership (PPP) initiatives. Meanwhile, the community is expressing new needs to be satisfied, such as the conversion of brownfields, the recovery of housing stock dating back to former times, as well as the refurbishment of public offices or schools. Emerging priorities include the supply of affordable dwellings for low to medium income households. This essay aims to examine a case study in which PPP and buildings energy efficiency have been successfully combined, in order to jointly contribute to the achievement of a social housing settlement. Thanks to energy efficiency measures—concerning building envelope insulation, heating system and other installations—the agreed rent results far higher than social rent of protected tenancies, and furthermore above the range of fair rents characterising other regulated tenancies, but mildly lower than market rents. All this allows to achieve an equity yield rate satisfying from the perspective of a venture philanthropy investment. -- Highlights: •Provision of affordable dwellings is an emerging priority within Italian context. •Lack of public funds leads to promote Public–Private Partnership schemes. •Without public grants the adoption of a venture philanthropy approach is needed. •The examined case study allows to explain the role of buildings energy efficiency. •Buildings energy efficiency may boost feasibility of social housing transactions

  10. Improving Student Achievement in Math and Science

    Science.gov (United States)

    Sullivan, Nancy G.; Hamsa, Irene Schulz; Heath, Panagiota; Perry, Robert; White, Stacy J.

    1998-01-01

    As the new millennium approaches, a long anticipated reckoning for the education system of the United States is forthcoming, Years of school reform initiatives have not yielded the anticipated results. A particularly perplexing problem involves the lack of significant improvement of student achievement in math and science. Three "Partnership" projects represent collaborative efforts between Xavier University (XU) of Louisiana, Southern University of New Orleans (SUNO), Mississippi Valley State University (MVSU), and the National Aeronautics and Space Administration (NASA), Stennis Space Center (SSC), to enhance student achievement in math and science. These "Partnerships" are focused on students and teachers in federally designated rural and urban empowerment zones and enterprise communities. The major goals of the "Partnerships" include: (1) The identification and dissemination of key indices of success that account for high performance in math and science; (2) The education of pre-service and in-service secondary teachers in knowledge, skills, and competencies that enhance the instruction of high school math and science; (3) The development of faculty to enhance the quality of math and science courses in institutions of higher education; and (4) The incorporation of technology-based instruction in institutions of higher education. These goals will be achieved by the accomplishment of the following objectives: (1) Delineate significant ?best practices? that are responsible for enhancing student outcomes in math and science; (2) Recruit and retain pre-service teachers with undergraduate degrees in Biology, Math, Chemistry, or Physics in a graduate program, culminating with a Master of Arts in Curriculum and Instruction; (3) Provide faculty workshops and opportunities for travel to professional meetings for dissemination of NASA resources information; (4) Implement methodologies and assessment procedures utilizing performance-based applications of higher order

  11. Various Means of Achieving Humor in English

    Institute of Scientific and Technical Information of China (English)

    温晓棠

    2014-01-01

    Humor can be found everywhere in our daily life. It shows one's wisdom and confidence, which reflects a person's character, mind and cultivation. While it makes people laugh, it enlightens and instruct people. As we all know, English humor is a manifestation of the western literature. However, people in non-English speaking countries cannot completely understand English humor because of the differences of different cultures. The present paper starts from the analysis of English humor, trying to find out some ways of achieving humor so as to better our understanding and appreciation of English humor.

  12. The evolution of language : Achievement or accident?

    OpenAIRE

    Matthews, John

    1996-01-01

    The ability of human beings to exchange ideas through language is frequently cited as one of the greatest achievements of our species-indeed, one that separates us from other animals. This paper brings together the major arguments put forth in the debate as to whether this uniquely human capacity has evolved by Darwinian natural selection and examines what each position presupposes language to be. By clarifying what it is that we refer to when we consider the evolution of language, it is obse...

  13. Achieving competitiveness through supply chain integration

    DEFF Research Database (Denmark)

    Wong, Chee Yew; Arlbjørn, Jan S.; Seerup, Søren

    2007-01-01

    of a Danish manufacturer that has gone through a major transformation process, and the paper intends to discuss how such a Business Process Reengineering (BPR) project aimed to achieve internal integration. The paper demonstrates how improved competitiveness can be obtained through a synchronous...... implementation of a new Enterprise Resource Planning (ERP) system together with BPR activities. From the very first day of the project, there was a clear focus on the construction and refinement of prototypes of core processes to meet competitive criteria. The paper provides further support for improving supply...

  14. Music Education and Cognitive Achievement of Children

    OpenAIRE

    ŞENDURUR, Yılmaz; BARIŞ, Dolunay AKGÜL

    2002-01-01

    This study aims to discover the effect of music education especially on the cognitive achievement of the children, and to emphasize that as it is generally thought music does not only apply to senses but also to minds by feelings and it takes an important part in the cognitive learning of the children at every age. For this study all the studies carried out in this field were examined and a mini research was conducted upon 26 students studying in the 2nd and 3rd year students of Ankara R...

  15. Student self-esteem and academic achievement

    OpenAIRE

    Milošević Nikoleta M.; Ševkušić Slavica

    2005-01-01

    There is a growing belief that academic achievement is the product of a complex network of teacher-student relations, where the identity of successful and unsuccessful student is developing with high, moderate or low self-esteem level. Self-esteem is most often defined as a conscious cognitive-affective expression of self-evaluation which is one of the most immediate indicators of self-concept integration degree. A number of authors view high self-esteem level as an important prerequisite for...

  16. ACHIEVING BETTER UNDERSTANDING BY LISTENING WITH PREDICTION

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The skill of Listening with comprehension is anessential part of communication and basic to ESL/EFL learning.Prediction is also a key process in un-derstanding spoken language.This article intends tooffer a definition for prediction in ESL/EFL listening,examines its foundations,draws some insights into itsnature,and illustrates how to develop and employprediction in pre-listening and while-listening stages,also how to‘repair’prediction in the post-listeningstage,in an attempt to help listeners achieve the goalof better understanding.

  17. Software quality - how is it achieved?

    International Nuclear Information System (INIS)

    Although software quality can't be quantified, the tools and techniques to achieve high quality are available. As management stresses the need for definable software quality programs from vendors and subcontractors and provides the incentives for these programs, the quality of software will improve. EPRI could provide the leadership in establishing guidelines for a balanced software quality program and through workshops provide training to utility staff and management on the methods for evaluating the characteristics of quality software. With the more complex systems discussed at this workshop and particularly with the trend toward the use of artificial intelligence, the importance of quality software will grow dramatically

  18. Achieving competences in patient-centred care

    DEFF Research Database (Denmark)

    Lomborg, Kirsten; Nielsen, Else Skånning; Jensen, Annesofie Lunde;

    2011-01-01

    . In order to achieve such competences in nursing staff, we developed, implemented and evaluated a training programme. Design: A qualitative outcome analysis was conducted in order to explore the dynamics of the training programme process and the outcome. patients to be more active, as was common practice...... prior to the training. According to the staff, there was no actual change in the patients’ level of activity. The training was time-consuming. Methods: Seven nurses and six nursing assistants from three hospital units were divided into two groups in which training and evaluation took place. The content...

  19. Achievements and Prospects of China's Hydropower Generation

    Institute of Scientific and Technical Information of China (English)

    Zhou Dabing

    2010-01-01

    @@ Outstanding achievements The scale of hydropower development con-tinuously expanding to a new level As a type of clean and renewable energy resource,water power takes an extremely important position in the energy layout of the world.The theoretic reservation of China's hydro energy is ranked the first in the world.But from the foundation of P.R.C.to the year of 1978(the year when the reform and opening-up took place),the hydro energy exploitation in the whole country was less than 10% of the reservation.

  20. Transcriptionally targeted gene therapy to detect and treat cancer

    OpenAIRE

    Wu, Lily; Johnson, Mai; Sato, Makoto

    2003-01-01

    The greatest challenge in cancer treatment is to achieve the highest levels of specificity and efficacy. Cancer gene therapy could be designed specifically to express therapeutic genes to induce cancer cell destruction. Cancer-specific promoters are useful tools to accomplish targeted expression; however, high levels of gene expression are needed to achieve therapeutic efficacy. Incorporating an imaging reporter gene in tandem with the therapeutic gene will allow tangible proof of principle t...

  1. Path To Ignition: US Indirect Target Physics (LIRPP Vol. 12)

    Science.gov (United States)

    Cray, M.; Campbell, E. M.

    2016-10-01

    The United States ICF Program has been pursuing an aggressive research program in preparation for an ignition demonstration on the National Ignition Facility. Los Alamos and Livermore laboratories have collaborated on resolving indirect drive target physics issues on the Nova laser at Livermore National Laboratory. This combined with detailed modeling of laser heated indirectly driven targets likely to achieve ignition, has provided the basis for planning for the NIF. A detailed understanding of target physics, laser performance, and target fabrication is required for developing robust ignition targets. We have developed large-scale computational models to simulate complex physics which occurs in an indirectly driven target. For ignition, detailed understanding of hohlraum and implosion physics is required in order to control competing processes at the few percent level. From crucial experiments performed by Los Alamos and Livermore on the Nova laser, a comprehensive indirect drive database has been assembled. Time integrated and time dependent measurements of radiation drive and symmetry coupled with a detailed set of plasma instability measurements have confirmed our ability to predict hohlraum energetics. Implosion physics campaigns are focused on underdstanding detailed capsule hydrodynamics and instability growth. Target fabrication technology is also an active area of research at Los Alamos, Livermore, and General Atomics for NIF. NIF targets require developing technology in cryogenics and manufacturing in such areas as beryllium shell manufacture. Descriptions of our NIF target designs, experimental results, and fabrication technology supporting NIF target performance predictions will be given.

  2. Development of a hydrogen and deuterium polarized gas target for application in storage rings

    International Nuclear Information System (INIS)

    Polarized gas targets of atomic hydrogen and deuterium have significant advantages over conventional polarized targets, e.g. chemical and isotopic purity, large polarization including deuteron tensor polarization, absence of strong magnetic fields, rapid polarization reversal. While in principle the beam of polarized atoms from an atomic beam source (Stern-Gerlach spin separation) can be used as a polarized target, the target thickness achieved is too small for most applications. We propose to increase the target thickness by injecting the polarized atoms into a storage cell. Provided the atoms survive several hundred wall collisions without losing their polarization, it will be possible to achieve a target thickness of 1013 to 1014 atoms/cm2 by injection of polarized atoms from an atomic-beam source into suitable cells. Such targets are very attractive as internal targets in storage rings

  3. Targeted therapy for sarcomas

    Directory of Open Access Journals (Sweden)

    Forscher C

    2014-03-01

    Full Text Available Charles Forscher,1 Monica Mita,2 Robert Figlin3 1Sarcoma Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 2Experimental Therapeutics Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 3Academic Development Program, Samuel Oschin Comprehensive Cancer Institute, and Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: Sarcomas are tumors of mesenchymal origin that make up approximately 1% of human cancers. They may arise as primary tumors in either bone or soft tissue, with approximately 11,280 soft tissue tumors and 2,650 bone tumors diagnosed each year in the United States. There are at least 50 different subtypes of soft tissue sarcoma, with new ones described with ever-increasing frequency. One way to look at sarcomas is to divide them into categories on the basis of their genetic make-up. One group of sarcomas has an identifiable, relatively simple genetic signature, such as the X:18 translocation seen in synovial sarcoma or the 11:22 translocation seen in Ewing's sarcoma. These specific abnormalities often lead to the presence of fusion proteins, such as EWS-FLI1 in Ewing's sarcoma, which are helpful as diagnostic tools and may become therapeutic targets in the future. Another group of sarcomas is characterized by complex genetic abnormalities as seen in leiomyosarcoma, osteosarcoma, and undifferentiated sarcoma. It is important to keep these distinctions in mind when contemplating the development of targeted agents for sarcomas. Different abnormalities in sarcoma could be divided by tumor subtype or by the molecular or pathway abnormality. However, some existing drugs or drugs in development may interfere with or alter more than one of the presented pathways. Keywords: sarcoma, targeted agents, tyrosine kinase inhibitors, mTor inhibition

  4. Self-reflection, gender and science achievement

    Science.gov (United States)

    Shoop, Kathleen A.

    Drawing on socio-cognitive learning theory, this study compared achievement scores of 134 male and female high school biology students randomly assigned to groups which either used self-reflection, used self-reflection and received feedback, or did not self-reflect. Following a pretest, the teacher provided self-reflection strategy instruction to students in the two intervention groups and then subsequently provided in-class self-reflection time for these groups. The posttest concluded the unit; the retention measure was five weeks later. A quasi-experimental 3 x 3 x 2 (time x intervention x gender) factorial repeated-measures control group design was used for this study; a repeated measures ANOVA and several one-way ANOVA's were used to answer the research questions. Results from the repeated-measures ANOVA revealed significant results for Time and Time x Intervention, with the reflection group demonstrating significantly lower gains from pretest to posttest than the other two groups. The ANOVA examining differences between those who reflected and those who reflected and received feedback provided significant results with similar results for the difference between the control group and the reflection group. For teachers and students this study provides several areas of practical significance. Primarily, teachers may find lower student achievement if students regularly self-reflect but do not receive feedback for their reflection.

  5. Dogs' Body Language Relevant to Learning Achievement.

    Science.gov (United States)

    Hasegawa, Masashi; Ohtani, Nobuyo; Ohta, Mitsuaki

    2014-01-01

    The facial expressions and body postures of dogs can give helpful information about their moods and emotional states. People can more effectively obedience train their dogs if we can identify the mannerisms associated with learning in dogs. The aim of this study was to clarify the dog's body language during operant conditioning to predict achievement in the test that followed by measuring the duration of behaviors. Forty-six untrained dogs (17 males and 26 females) of various breeds were used. Each session consisted of 5 minutes of training with a treat reward followed by 3 minutes of rest and finally an operant conditioning test that consisted of 20 "hand motion" cues. The operant tests were conducted a total of nine times over three consecutive days, and the success numbers were counted. The duration of the dog's behavior, focusing on the dog's eyes, mouth, ears, tail and tail-wagging, was recorded during the operant conditioning sessions before the test. Particular behaviors, including wide-eyes, closed mouth, erect ears, and forward and high tail carriage, without wagging or with short and quick wagging, related to high achievement results. It is concluded that dogs' body language during operant conditioning was related to their success rate.

  6. District Fiscal Policy and Student Achievement

    Directory of Open Access Journals (Sweden)

    Gary G. Huang

    2002-09-01

    Full Text Available School restructuring raises questions about the role of school districts in improving student learning. Centralization by state governments and decentralization to individual schools as proposed in systemic reform leave districts' role unsettled. Empirical research on the district role in the context of ongoing reform is inadequate. This analysis of combined data from the NAEP and the Common Core of Data (CCD was intended to address the issue. We analyzed 1990, 1992, and 1996 NAEP 8th grade mathematics national assessment data in combination with CCD data of corresponding years to examine the extent to which student achievement was related to districts' control over instructional expenditure, adjusting for relevant key factors at both district and student levels. Upon sample modification, we used hierarchical linear modeling (HLM to estimate the relationships of student achievement to two district fiscal policy indictors, current expenditure per pupil (CEPP and districts' discretionary rates for instructional expenditure (DDR. Net of relevant district factors, DDR was found unrelated to districts' average 8th grade math performance. The null effect was consistent in the analysis of the combined NAEP-CCD data for 1990, 1992, and 1996. In contrast, CEPP was found related to higher math performance in a modest yet fairly consistent way. Future research may be productive to separately study individual states and integrate the findings onto the national level.

  7. VULNERABILITIES IN ACHIEVING AGRICULTURAL POTENTIAL OF ROMANIA

    Directory of Open Access Journals (Sweden)

    Cristian TEODOR

    2014-10-01

    Full Text Available The land fund of Romania represents a huge potential for agriculture. The potential has proved difficult to achieve, and among the main vulnerabilities researched lately, we have identified the decline in consumption of vegetable crops, fruit and meat, determined by the declining purchasing power in Romania and the European Union's common market. Therefore the degree of achievement of the agricultural potential is directly influenced by economic developments in Romania and EU Member States. The technical endowment of Romanian farmers is an old and still unresolved problem. Even though Romania has benefited from EU pre-accession funds and still benefits from it, they proved to be a poor solution for Romanian farmers with farm machinery equipment. Indicator analysis of the evolution of the number of tractors in Romania in the post-accession period, reveals that the actual number of tractors in the period under review increased overall, but even if the total number of tractors in Romania increased from 2007 until 2012, UAA (ha per a tractor is almost constant.

  8. Deflection of uncooperative targets using laser ablation

    Science.gov (United States)

    Thiry, Nicolas; Vasile, Massimiliano

    2015-09-01

    Owing to their ability to move a target in space without requiring propellant, laser-based deflection methods have gained attention among the research community in the recent years. With laser ablation, the vaporized material is used to push the target itself allowing for a significant reduction in the mass requirement for a space mission. Specifically, this paper addresses two important issues which are thought to limit seriously the potential efficiency of a laser-deflection method: the impact of the tumbling motion of the target as well as the impact of the finite thickness of the material ablated in the case of a space debris. In this paper, we developed a steady-state analytical model based on energetic considerations in order to predict the efficiency range theoretically allowed by a laser deflection system in absence of the two aforementioned issues. A numerical model was then implemented to solve the transient heat equation in presence of vaporization and melting and account for the tumbling rate of the target. This model was also translated to the case where the target is a space debris by considering material properties of an aluminium 6061-T6 alloy and adapting at every time-step the size of the computational domain along with the recession speed of the interface in order to account for the finite thickness of the debris component. The comparison between the numerical results and the analytical predictions allow us to draw interesting conclusions regarding the momentum coupling achievable by a given laser deflection system both for asteroids and space debris in function of the flux, the rotation rate of the target and its material properties. In the last section of this paper, we show how a reasonably small spacecraft could deflect a 56m asteroid with a laser system requiring less than 5kW of input power.

  9. Robust, Distributed Target Tracking Using Sensor Network

    Science.gov (United States)

    Neema, Kartavya

    Distributed target tracking using sensor networks is crucial for supporting a variety of applications such as battlefield monitoring, weather monitoring, and air traffic management. This dissertation presents a problem formulation and solution approach for distributed target tracking, comprising of sensor fusion and sensor target allocation problems, in the presence of faults in the sensor measurements. There are times when an architecture with central node is preferred but other times when distributed is necessary, we seek a distributed case that can approach the attractive features of centralized case. Therefore, we propose that the underlying two-fold goals of the distributed target tracking problem is to: (1) reach a consensus in the allocation decisions across the sensor network, and (2) achieve a consensus in the state estimates across all the sensors in the network. These goals ensure that each sensor node has the same information across the sensor network, and any node can behave as a central node. In the process of achieving our goals, we develop two new algorithms, one for distributed sensor-target allocation and another for distributed sensor fusion. The Dual Phase Consensus Algorithm (DPCA) for distributed sensor target allocation is a real time algorithm that works in two phases. The first phase of DPCA is similar to distributed sequential greedy search that combines the benefits of greedy and consensus algorithms to reach a feasible solution. The second phase iteratively improves the allocation eventually leading toward a global optimum. DPCA converges to a feasible solution at the order of number of sensors, and thus can be useful for implementation in real time systems. For distributed sensor fusion, we extend the state-of-art distributed Kalman filtering technique called Generalized Kalman Consensus Filter (GKCF), and make it robust against faults present in the sensor measurements. We particularly focus on two types of faults: (1) outliers in the

  10. Targeted Social Mobilisation in a Global Manhunt

    CERN Document Server

    Rutherford, Alex; Rahwan, Iyad; Dsouza, Sohan; McInerney, James; Naroditskiy, Victor; Venanzi, Matteo; Jennings, Nicholas R; deLara, J R; Wahlstedt, Eero; Miller, Steven U

    2013-01-01

    Social mobilization, the ability to mobilize large numbers of people via social networks to achieve highly distributed tasks, has received significant attention in recent times. This growing capability, facilitated by modern communication technology, is highly relevant to endeavors which require the search for individuals that posses rare information or skill, such as finding medical doctors during disasters, or searching for missing people. An open question remains, as to whether in time-critical situations, people are able to recruit in a targeted manner, or whether they resort to so-called blind search, recruiting as many acquaintances as possible via broadcast communication. To explore this question, we examine data from our recent success in the U.S. State Department's Tag Challenge, which required locating and photographing 5 target persons in 5 different cities in the United States and Europe in less than 12 hours, based only on a single mug-shot. We find that people are able to consistently route info...

  11. Mining metabolic networks for optimal drug targets.

    Science.gov (United States)

    Sridhar, Padmavati; Song, Bin; Kahveci, Tamer; Ranka, Sanjay

    2008-01-01

    Recent advances in bioinformatics promote drug-design methods that aim to reduce side-effects. Efficient computational methods are required to identify the optimal enzyme-combination (i.e., drug targets) whose inhibition, will achieve the required effect of eliminating a given target set of compounds, while incurring minimal side-effects. We formulate the optimal enzyme-combination identification problem as an optimization problem on metabolic networks. We define a graph based computational damage model that encapsulates the impact of enzymes onto compounds in metabolic networks. We develop a branch-and-bound algorithm, named OPMET, to explore the search space dynamically. We also develop two filtering strategies to prune the search space while still guaranteeing an optimal solution. They compute an upper bound to the number of target compounds eliminated and a lower bound to the side-effect respectively. Our experiments on the human metabolic network demonstrate that the proposed algorithm can accurately identify the target enzymes for known successful drugs in the literature. Our experiments also show that OPMET can reduce the total search time by several orders of magnitude as compared to the exhaustive search. PMID:18229694

  12. Low intensity beam target unit

    CERN Multimedia

    1976-01-01

    This is a wheel fitted with many targets around its periphery (each with three longitudinally arranged thin rods) of which one is placed into the beam via a rotation of the wheel. Upstream of each target is placed a luminescent screen, aligbed on each target axis and viewed with a TV camera, to make sure that one is hitting the target. This target unit was probably used to study target's behaviour (like beam heating). Gualtiero Del Torre stands on the left, Pierre Gerdil on the right.

  13. Target Housing Material Options

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    With gas cooling, heat transfer coefficients are low compared to water. The benefit of gas from a heat transfer point of view is that there is really no upper temperature limit for the coolant, as compared to water, which is limited ultimately by the critical point, and in practice the critical heat flux. In our case with parallel flow channels, water is limited to even lower operating limits by nucleate boiling. So gas can get as hot as the containment material will allow, but to get the density and heat transfer up to something reasonable, we must also increase pressure, thus increasing stress on the containment, namely the front and back faces. We are designing to ASME BPVC, which, for most materials allows a maximum stress of UTS/3. So we want the highest possible UTS. For reference, the front face stress in the 12 mm target at 300 psi was about 90 MPa. The inconel 718 allowable stress at 900°C is 1/3 of 517 or 172 MPa. So we are in a very safe place, but the uTS is dropping rapidly with temperature above 900°C. As we increase target diameter, the challenge will be to keep the stress down. We are probably looking at keeping the allowable at or above the present value, and at as high a temperature as possible.

  14. CERN's Fixed Target Primary Ion Programme

    CERN Document Server

    Manglunki, Django; Axensalva, Jerome; Bellodi, Giulia; Blas, Alfred; Bodendorfer, Michael; Bohl, Thomas; Cettour-Cave, Stephane; Cornelis, Karel; Damerau, Heiko; Efthymiopoulos, Ilias; Fabich, Adrian; Ferreira Somoza, Jose; Findlay, Alan; Freyermuth, Pierre; Gilardoni, Simone; Hancock, Steven; Holzer, Eva Barbara; Jensen, Steen; Kain, Verena; Küchler, Detlef; Lombardi, Alessandra; Michet, Alice; O'Neil, Michael; Pasinelli, Sergio; Scrivens, Richard; Steerenberg, Rende; Tranquille, Gerard

    2016-01-01

    The renewed availability of heavy ions at CERN for the needs of the LHC programme has triggered the interest of the fixed-target community. The project, which involves sending several species of primary ions at various energies to the North Area of the Super Proton Synchrotron, has now entered its operational phase. The first argon run, with momenta ranging from 13 AGeV/c to 150 AGeV/c, took place from February 2015 to April 2015. This paper presents the status of the project, the performance achieved thus far and an outlook on future plans.

  15. Targeted anticancer therapy: overexpressed receptors and nanotechnology.

    Science.gov (United States)

    Akhtar, Mohd Javed; Ahamed, Maqusood; Alhadlaq, Hisham A; Alrokayan, Salman A; Kumar, Sudhir

    2014-09-25

    Targeted delivery of anticancer drugs to cancer cells and tissues is a promising field due to its potential to spare unaffected cells and tissues, but it has been a major challenge to achieve success in these therapeutic approaches. Several innovative approaches to targeted drug delivery have been devised based on available knowledge in cancer biology and on technological advancements. To achieve the desired selectivity of drug delivery, nanotechnology has enabled researchers to design nanoparticles (NPs) to incorporate anticancer drugs and act as nanocarriers. Recently, many receptor molecules known to be overexpressed in cancer have been explored as docking sites for the targeting of anticancer drugs. In principle, anticancer drugs can be concentrated specifically in cancer cells and tissues by conjugating drug-containing nanocarriers with ligands against these receptors. Several mechanisms can be employed to induce triggered drug release in response to either endogenous trigger or exogenous trigger so that the anticancer drug is only released upon reaching and preferentially accumulating in the tumor tissue. This review focuses on overexpressed receptors exploited in targeting drugs to cancerous tissues and the tumor microenvironment. We briefly evaluate the structure and function of these receptor molecules, emphasizing the elegant mechanisms by which certain characteristics of cancer can be exploited in cancer treatment. After this discussion of receptors, we review their respective ligands and then the anticancer drugs delivered by nanotechnology in preclinical models of cancer. Ligand-functionalized nanocarriers have delivered significantly higher amounts of anticancer drugs in many in vitro and in vivo models of cancer compared to cancer models lacking such receptors or drug carrying nanocarriers devoid of ligand. This increased concentration of anticancer drug in the tumor site enabled by nanotechnology could have a major impact on the efficiency of cancer

  16. Hands-on science and student achievement

    Science.gov (United States)

    Ruby, Allen Michael

    From the late 1950s through today, hands-on science has been promoted as a method of science instruction. Currently, recent national science reform efforts seek to temper its role. However, no consensus has been reached on the relationship of hands-on science to student achievement though this topic has been researched since the turn of the 20th century using various methods. To improve upon the literature, this work addresses three major limitations of past research---the lack of data on performance assessments of student achievement, the need to control for factors affecting both hands-on science and test scores, and the potential for a differential relationship by student ability. This work focuses on three research questions: (1) whether hands-on science is positively related to student achievement as measured by standardized test scores using both multiple choice and performance tests, (2) whether this relationship is stronger when using performance tests, and (3) whether this relationship differs by student ability. We apply regression analysis to two data sources. The primary data set is the 1994 RAND Survey of 1400 8th grade students and their teachers in Southern California which includes multiple choice and performance test scores. A second data source is the nationally representative NELS:88 with a focus on the 8th grade student sample. The initial findings vary by source of report, student or teacher, on the level of hands-on science. When accounting for the quality of the reports, the results show an association between the level of handson science and student test scores for both multiple choice and performance tests. The results find little difference for this relationship by type of test. Nor do they show strong evidence for a differential relationship due to student ability. These findings support the promotion of hands-on science at the middle school/junior high level while raising a concern about current science reform attempts to reduce and

  17. Investigation of IFMIF target assembly structure design

    International Nuclear Information System (INIS)

    In the International Fusion Materials Irradiation Facility (IFMIF), the back-wall of target assembly is the part suffered the highest neutron-flux. The back-wall and the assembly are designed to have lips for cutting/welding at the back-wall replacement. To reduce thermal stress and deformation of the back-wall under neutron irradiation, contact pressure between the back-wall and the assembly is one of dominant factors. Therefore, an investigation was performed for feasible clamping pressure of a mechanical clamp set in limited space around the back-wall. It was clarified that the clamp can give a pressure difference up to 0.4 MPa between the contact pressure and atmosphere pressure in the test cell room. Also a research was performed for the dissimilar metal welding in the back-wall. Use of 309 steel was found adequate as the intermediate filler metal through the research of previous welding. Maintaining a temperature of the target assembly so as to avoid a freezing of liquid lithium is needed at the lithium charge into the loop before the beam injection. The assembly is covered with thermal insulation. Therefore, a research and an investigation were performed for compact and light thermal-insulation effective even under helium (i.e. high heat-conduction) condition of the test cell room. The result was as follows; in the case that a thermal conductivity 0.008 W/m·K of one of found insulation materials is available in the temperature range up to 300degC of the IFMIF target assembly, needed thickness and weight of the insulation were respectively only 8.2 mm and 32 kg. Also a research was performed for high-heat-density heaters to maintain temperature of the back-wall which can not be cover with insulation due to limited space. A heater made of silicon-nitride was found to be adequate. Total heat of 8.4 kW on the back-wall was found to be achievable through an investigations of heater arrange. Also an investigation was performed for remote-handling device to

  18. Sugared biomaterial binding lectins: achievements and perspectives.

    Science.gov (United States)

    Bojarová, P; Křen, V

    2016-07-19

    Lectins, a distinct group of glycan-binding proteins, play a prominent role in the immune system ranging from pathogen recognition and tuning of inflammation to cell adhesion or cellular signalling. The possibilities of their detailed study expanded along with the rapid development of biomaterials in the last decade. The immense knowledge of all aspects of glycan-lectin interactions both in vitro and in vivo may be efficiently used in bioimaging, targeted drug delivery, diagnostic and analytic biological methods. Practically applicable examples comprise photoluminescence and optical biosensors, ingenious three-dimensional carbohydrate microarrays for high-throughput screening, matrices for magnetic resonance imaging, targeted hyperthermal treatment of cancer tissues, selective inhibitors of bacterial toxins and pathogen-recognising lectin receptors, and many others. This review aims to present an up-to-date systematic overview of glycan-decorated biomaterials promising for interactions with lectins, especially those applicable in biology, biotechnology or medicine. The lectins of interest include galectin-1, -3 and -7 participating in tumour progression, bacterial lectins from Pseudomonas aeruginosa (PA-IL), E. coli (Fim-H) and Clostridium botulinum (HA33) or DC-SIGN, receptors of macrophages and dendritic cells. The spectrum of lectin-binding biomaterials covered herein ranges from glycosylated organic structures, calixarene and fullerene cores over glycopeptides and glycoproteins, functionalised carbohydrate scaffolds of cyclodextrin or chitin to self-assembling glycopolymer clusters, gels, micelles and liposomes. Glyconanoparticles, glycan arrays, and other biomaterials with a solid core are described in detail, including inorganic matrices like hydroxyapatite or stainless steel for bioimplants. PMID:27075026

  19. Preparation of a 1 mg/cm213C target

    International Nuclear Information System (INIS)

    We give a description for the production of 13C foils and the preparation of an approximately 1 mg/cm2 thick target. A recent experiment to measure the mass of 36Ca via the 40Ca(4He,8He)36Ca reaction at the S800 magnetic spectrometer at MSU, needed a precise determination of the beam energy and calibration of the focal plane of the magnetic spectrometer in order to achieve the most accurate value for the 36Ca mass. The 1 mg/cm213C target was essential for these purposes. Target performance along with some preliminary results will also be discussed

  20. Array Processing for Radar: Achievements and Challenges

    Directory of Open Access Journals (Sweden)

    Ulrich Nickel

    2013-01-01

    Full Text Available Array processing for radar is well established in the literature, but only few of these algorithms have been implemented in real systems. The reason may be that the impact of these algorithms on the overall system must be well understood. For a successful implementation of array processing methods exploiting the full potential, the desired radar task has to be considered and all processing necessary for this task has to be eventually adapted. In this tutorial paper, we point out several viewpoints which are relevant in this context: the restrictions and the potential provided by different array configurations, the predictability of the transmission function of the array, the constraints for adaptive beamforming, the inclusion of monopulse, detection and tracking into the adaptive beamforming concept, and the assessment of superresolution methods with respect to their application in a radar system. The problems and achieved results are illustrated by examples from previous publications.

  1. Improving Outcome Measures Other Than Achievement

    Directory of Open Access Journals (Sweden)

    Kristin Anderson Moore

    2015-05-01

    Full Text Available Research indicates that educational, economic, and life success reflect children’s nonacademic as well as academic competencies. Therefore, longitudinal surveys that assess educational progress and success need to incorporate nonacademic measures to avoid omitted variable bias, inform development of new intervention strategies, and support mediating and moderating analyses. Based on a life course model and a whole child perspective, this article suggests constructs in the domains of child health, emotional/psychological development, educational achievement/attainment, social behavior, and social relationships. Four critical constructs are highlighted: self-regulation, agency/motivation, persistence/diligence, and executive functioning. Other constructs that are currently measured need to be retained, including social skills, positive relationships, activities, positive behaviors, academic self-efficacy, educational engagement, and internalizing/emotional well-being. Examples of measures that are substantively and psychometrically robust are provided.

  2. Achieving excellence on shift through teamwork

    International Nuclear Information System (INIS)

    Anyone familiar with the nuclear industry realizes the importance of operators. Operators can achieve error-free plant operations, i.e., excellence on shift through teamwork. As a shift supervisor (senior reactor operator/shift technical advisor) the author went through the plant's first cycle of operations with no scrams and no equipment damaged by operator error, having since changed roles (and companies) to one of assessing plant operations. This change has provided the opportunity to see objectively the importance of operators working together and of the team building and teamwork that contribute to the shift's success. This paper uses examples to show the effectiveness of working together and outlines steps for building a group of operators into a team

  3. Does cultural capital really affect academic achievement?

    DEFF Research Database (Denmark)

    Jæger, Mads Meier

    2011-01-01

    This paper provides new estimates of the causal effect of cultural capital on academic achievement. The author analyzes data from the National Longitudinal Survey of Youth – Children and Young Adults and uses a fixed effect design to address the problem of omitted variable bias which has resulted...... in too optimistic results in previous research. After controlling for family and individual fixed effects, the author reports that (1) six indicators of cultural capital have mostly positive direct effects on children’s reading and math test scores; (2) the effect of cultural capital is smaller than...... previously reported; and (3) the effect of cultural capital varies in high- and low-SES environments. Results mostly support cultural reproduction theory (cultural capital more important in high-SES environments) for cultural capital indicators capturing familiarity with legitimate culture and mostly support...

  4. Nuclear plant operation: achieving excellence through quality

    International Nuclear Information System (INIS)

    Nuclear power operation is characterised by a very high level of safety and availability resulting in economically competitive electricity production. This achievement must not only be maintained but must be further developed if nuclear power is to regain momentum in the light of its widely recognized environmental advantages. Therefore this meeting bring together all those, managers and technical staff, responsible for the operation of the nuclear in order to allow them to exchange views, experience and knowledge on fundamental aspects such as: management philosophy, quality assurance, human resources and international co-operation; focusing on training (incident analysis and management), human factors and experience feedback; maintenance philosophy, life extension and upgrading, organisation and administration. (A.L.B.)

  5. Achieving year 2000 readiness: basic processes

    International Nuclear Information System (INIS)

    This document provides an approach or addressing safety and operability concerns related to Year 2000 (Y2K). Although it was prepared for nuclear power plants the methods described are applicable to other nuclear installations and to other industrial concerns. The basic goal was to provide a brief but comprehensive approach that may be used to discover, understand and correct the Y2K related problems. The document relies on certain basic expectations of the facility that would apply to any programme: ownership, management, knowledgeable participants, thorough application of the approach, documentation of efforts, quality assurance of products and compliance with all regulatory requirements. The IAEA has and will continue to be involved with Member States to assist them in implementing this document and achieving Y2K Readiness

  6. International energy technology collaboration: benefits and achievements

    International Nuclear Information System (INIS)

    The IEA Energy Technology Collaboration Programme facilitates international collaboration on energy technology research, development and deployment. More than 30 countries are involved in Europe, America, Asia, Australasia and Africa. The aim is to accelerate the development and deployment of new energy technologies to meet energy security, environmental and economic development goals. Costs and resources are shared among participating governments, utilities, corporations and universities. By co-operating, they avoid unproductive duplication and maximize the benefits from research budgets. The IEA Programme results every year in hundreds of publications which disseminate information about the latest energy technology developments and their commercial utilisation. The IEA Energy Technology Collaboration Programme operates through a series of agreements among governments. This report details the activities and achievements of all 41 agreements, covering energy technology information centres and Research and Development projects in fossil fuels, renewable energy efficient end-use, and nuclear fusion technologies. (authors). 58 refs., 9 tabs

  7. Achieving HBSE Competencies through Service-learning

    Directory of Open Access Journals (Sweden)

    Sarah E. Twill

    2011-04-01

    Full Text Available Service-learning pedagogy allows social work educators to create meaningful learning opportunities for students and better prepare them for practicum, while at the same time, meeting a community need. This paper outlines the relevance of incorporating service-learning into the social work curriculum, specifically the human behavior and the social environment (HBSE area. Using Bloom’s taxonomy as a guide, the authors propose how the CSWE competencies and practice behaviors specific to HBSE may be assessed using service-learning pedagogy. An example is reviewed to illustrate how service-learning can assist faculty and students achieve the HBSE competencies and practice behaviors. Finally, implications for service-learning as a pedagogical strategy for social work education are discussed.

  8. Nuclear plant operation: achieving excellence through quality

    Energy Technology Data Exchange (ETDEWEB)

    Bergstrom, L. [Barseback Nuclear Power Plant (Sweden); Bergeron, J.P. [Electricite de France (EDF), 75 - Paris (France); Coakley, W. [and others

    1992-07-01

    Nuclear power operation is characterised by a very high level of safety and availability resulting in economically competitive electricity production. This achievement must not only be maintained but must be further developed if nuclear power is to regain momentum in the light of its widely recognized environmental advantages. Therefore this meeting bring together all those, managers and technical staff, responsible for the operation of the nuclear in order to allow them to exchange views, experience and knowledge on fundamental aspects such as: management philosophy, quality assurance, human resources and international co-operation; focusing on training (incident analysis and management), human factors and experience feedback; maintenance philosophy, life extension and upgrading, organisation and administration. (A.L.B.)

  9. ACHIEVING SUSTAINABLE TOURISM THROUGH CUSTOMER SATISFACTION

    Directory of Open Access Journals (Sweden)

    Ispas Roxana

    2012-12-01

    Full Text Available In tourism, hotels play an important role and contribute to the economic growth in cities and other places endowed with attractions which are universally recognized. Two elements are essential in the tourism industry system: product quality and human resources. In terms of quality of the hotel services, that is the one that allows to the tourist enterprise to own a competitive advantage, gain competitive differentiation and reputation among customers by achieving a high degree of customer satisfaction. Hotel customer satisfaction would be impossible if the hotel management does not perform periodic evaluations on customer satisfaction and quality, which are the focus of this paper. Therefore, this paper focuses on customer satisfaction measured by the SERVQUAL model.

  10. Achieving true sustainability of zoo populations.

    Science.gov (United States)

    Lacy, Robert C

    2013-01-01

    For the last 30 years, cooperative management of irreplaceable animal populations in zoos and aquariums has focused primarily on the goal of minimizing genetic decay within defined time frames, and large advances have been made in technologies to optimize genetic management of closed populations. However, recent analyses have shown that most zoo programs are not projected to meet their stated goals. This has been described as a lack of achieving "sustainability" of the populations, yet by definition a goal of managed decay is not a plan for sustainability. True sustainability requires management of the resource in manner that does not deplete its value for the future. Achieving such sustainability for many managed populations may require changing from managing isolated populations to managing populations that are part of a broader metapopulation, with carefully considered exchange between populations across a spectrum of ex situ to in situ. Managing zoo populations as components of comprehensive conservation strategies for the species will require research on determinants of various kinds of genetic, physiological, behavioral, and morphological variation and their roles in population viability, development of an array of management techniques and tools, training of population managers in metapopulation management and integrated conservation planning, and projections of impacts of management strategies on the viability of the captive populations and all populations that are interactively managed or affected. Such a shift in goals and methods would result in zoo population management being an ongoing part of species conservation rather than short-term or isolated from species conservation. Zoo Biol. 32:19-26, 2013. © 2012 Wiley Periodicals, Inc.

  11. Achieving success: moving beyond the comfort level.

    Science.gov (United States)

    Manji, I

    1993-11-01

    Understanding the stages of growth, saturation and transition is the first step to setting meaningful career goals. While this concept is fairly new in dentistry, it is not new in other commercial enterprises. Business managers and owners have known for decades that growth stagnates after a period of time. At that point, a new infusion of energy and a reformation of the business's objectives and methods are needed to launch forward into the next phase of growth. Transition management in dentistry represents periods of growth that are followed by saturation and a comparatively rapid changeover to a new practice form. Saturation occurs when the clinical capacity of a practice is exceeded by the needs of a growing patient base. The key transitions in the career of a dentist are those from school to practising, and practising to retirement. A great number of dentists (due to low motivation, the comfort level or poor management skills) never reach the saturation point during their practising career. For these dentists, starting out and retirement are the only transitions that will ever apply to them. Dentists evaluating transition options must first identify which career stage they belong to since their objectives will be different at each stage. Dentists in the growth phase should focus on practice management and achieving saturation before attempting a transition. Since transitions like start-up, retirement, partnerships, associateships and buy-ins have pivotal roles in the life cycle of a practice, transitions must be managed carefully to achieve successful results.(ABSTRACT TRUNCATED AT 250 WORDS)

  12. A Year of Exceptional Achievements FY 2008

    Energy Technology Data Exchange (ETDEWEB)

    devore, L; Chrzanowski, P

    2008-11-06

    2008 highlights: (1) Stockpile Stewardship and Complex Transformation - LLNL achieved scientific breakthroughs that explain some of the key 'unknowns' in nuclear weapons performance and are critical to developing the predictive science needed to ensure the safety, reliability, and security of the U.S. nuclear deterrent without nuclear testing. In addition, the National Ignition Facility (NIF) passed 99 percent completion, an LLNL supercomputer simulation won the 2007 Gordon Bell Prize, and a significant fraction of our inventory of special nuclear material was shipped to other sites in support of complex transformation. (2) National and Global Security - Laboratory researchers delivered insights, technologies, and operational capabilities that are helping to ensure national security and global stability. Of particular note, they developed advanced detection instruments that provide increased speed, accuracy, specificity, and resolution for identifying and characterizing biological, chemical, nuclear, and high-explosive threats. (3) Exceptional Science and Technology - The Laboratory continued its tradition of scientific excellence and technical innovation. LLNL scientists made significant contributions to Nobel Prize-winning work on climate change. LLNL also received three R&D 100 awards and six Nanotech 50 awards, and dozens of Laboratory scientists and engineers were recognized with professional awards. These honors provide valuable confirmation that peers and outside experts recognize the quality of our staff and our work. (4) Enhanced Business and Operations - A major thrust under LLNS is to make the Laboratory more efficient and cost competitive. We achieved roughly $75 million in cost savings for support activities through organizational changes, consolidation of services, improved governance structures and work processes, technology upgrades, and systems shared with Los Alamos National Laboratory. We realized nonlabor cost savings of $23 million

  13. Computational design of nanoparticle drug delivery systems for selective targeting

    Science.gov (United States)

    Duncan, Gregg A.; Bevan, Michael A.

    2015-09-01

    Ligand-functionalized nanoparticles capable of selectively binding to diseased versus healthy cell populations are attractive for improved efficacy of nanoparticle-based drug and gene therapies. However, nanoparticles functionalized with high affinity targeting ligands may lead to undesired off-target binding to healthy cells. In this work, Monte Carlo simulations were used to quantitatively determine net surface interactions, binding valency, and selectivity between targeted nanoparticles and cell surfaces. Dissociation constant, KD, and target membrane protein density, ρR, are explored over a range representative of healthy and cancerous cell surfaces. Our findings show highly selective binding to diseased cell surfaces can be achieved with multiple, weaker affinity targeting ligands that can be further optimized by varying the targeting ligand density, ρL. Using the approach developed in this work, nanomedicines can be optimally designed for exclusively targeting diseased cells and tissues.Ligand-functionalized nanoparticles capable of selectively binding to diseased versus healthy cell populations are attractive for improved efficacy of nanoparticle-based drug and gene therapies. However, nanoparticles functionalized with high affinity targeting ligands may lead to undesired off-target binding to healthy cells. In this work, Monte Carlo simulations were used to quantitatively determine net surface interactions, binding valency, and selectivity between targeted nanoparticles and cell surfaces. Dissociation constant, KD, and target membrane protein density, ρR, are explored over a range representative of healthy and cancerous cell surfaces. Our findings show highly selective binding to diseased cell surfaces can be achieved with multiple, weaker affinity targeting ligands that can be further optimized by varying the targeting ligand density, ρL. Using the approach developed in this work, nanomedicines can be optimally designed for exclusively targeting

  14. THE ROLE OF THE ICT SECTOR IN ACHIEVING SUSTAINABLE DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    TEODORESCU ANA MARIA

    2015-06-01

    Full Text Available Sustainable development requires the merge of objectives for economic growth, quality of life and environmental protection. If in the 70’s the need to shift towards sustainable development has been made on the basis of environmental concerns, with the Brundtland Report the concept gains economic and social dimensions. Challenges such as technology, globalization, competition, efficiency, competitiveness, determine the businesses need to adapt to the new economy. Support information to doing business in these conditions is given by IT. The transition to the information society is considered a step to achieve sustainable development. Information, which became resource both in the business and in everyday environment, is the challenge that economic and social pillars of sustainable development must potency. Based on the review of interest for the concept "information society" in Europe, this article discusses the impact of the ICT sector on economic and social pillars of sustainable development. Information and Communication Technology, identified as the fifth wave of technological innovation, is the support of information society. It is playing a supporting role for the activities of all areas with a significant impact on the economy and quality of life. Quantification of any process can be achieved through indicators, created to reflect the progression or regression of the proposed targets. Indicators are tools for measuring any process, so their importance is essential for making decision. Using the scheme of interactions between the pillars of sustainable development proposed by the Organisation for Economic Cooperation and Development, I have emphasized the role of the ICT sector on the social and economic pillar. Based on the relations established, I analyzed the results of the information society indicators at european level. Although in Europe plans and strategies on the transition to a knowledge economy were developed in the last 15

  15. Accelerator-based fusion with a low temperature target

    Science.gov (United States)

    Phillips, R. E.; Ordonez, C. A.

    2013-04-01

    Neutron generators are in use in a number of scientific and commercial endeavors. They function by triggering fusion reactions between accelerated ions (usually deuterons) and a stationary cold target (e.g., containing tritium). This setup has the potential to generate energy. It has been shown that if the energy transfer between injected ions and target electrons is sufficiently small, net energy gain can be achieved. Three possible avenues are: (a) a hot target with high electron temperature, (b) a cold non-neutral target with an electron deficiency, or (c) a cold target with a high Fermi energy. A study of the third possibility is reported in light of recent research that points to a new phase of hydrogen, which is hypothesized to be related to metallic hydrogen. As such, the target is considered to be composed of nuclei and delocalized electrons. The electrons are treated as conduction electrons, with the average minimum excitation energy being approximately equal to 40% of the Fermi energy. The Fermi energy is directly related to the electron density. Preliminary results indicate that if the claimed electron densities in the new phase of hydrogen were achieved in a target, the energy transfer to electrons would be small enough to allow net energy gain.

  16. A Note on Inflation Targeting.

    Science.gov (United States)

    Lai, Ching-chong; Chang, Juin-jen

    2001-01-01

    Presents a pedagogical graphical exposition to illustrate the stabilizing effect of price target zones. Finds that authorities' commitment to defend a price target zone affects the public's inflation expectations and, in turn, reduces actual inflation. (RLH)

  17. ACHIEVING SUSTAINABILITY - FINAL STEPS IN A DYNAMIC DANCE

    Science.gov (United States)

    Achieving sustainability relies upon adequate metrics to evaluate the environment and guide decisions. Although adequate assessment is important to prescribing remedies, achieving a sustainable environment cannot be delayed. It must be achieved today as well as tomorrow so that t...

  18. Proton beam production by a laser ion source with hydride target

    Energy Technology Data Exchange (ETDEWEB)

    Okamura, M., E-mail: okamura@bnl.gov [Collider-Accelerator Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Nishina Center for Accelerator-Based Science, RIKEN, Saitama (Japan); Stifler, C. [Engineering Physics Systems Department, Providence College, Providence, Rhode Island 02918 (United States); Palm, K. [Department of Physics, Cornell University, Ithaca, New York 14853 (United States); Steski, D.; Kanesue, T. [Collider-Accelerator Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Ikeda, S. [Nishina Center for Accelerator-Based Science, RIKEN, Saitama (Japan); Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Kanagawa (Japan); Kumaki, M. [Nishina Center for Accelerator-Based Science, RIKEN, Saitama (Japan); Research Institute for Science and Engineering, Waseda University, Tokyo (Japan)

    2016-02-15

    We studied proton beam production from a laser ion source using hydrogen rich target materials. In general, gas based species are not suitable for laser ion sources since formation of a dense laser target is difficult. In order to achieve reliable operation, we tested hydride targets using a sub nanosecond Q-switched Nd-YAG laser, which may help suppress target material consumption. We detected enough yields of protons from a titanium hydride target without degradation of beam current during the experiment. The combination of a sub nanosecond laser and compressed hydride target may provide stable proton beam.

  19. TARGET DETECTION USING MULTI-RESOLUTION ANALYSIS AND HOLDER CONSTANT

    Institute of Scientific and Technical Information of China (English)

    Liu Wenyu; Li Hua; Zhu Guangxi

    2001-01-01

    Through analyzing the different height parameter of 3D surface between the artificial target and complex background based on the description of average Holder constant of fractional Brownian motion, a novel method of target detection based on wavelet transformation and Holder constant is proposed. The wavelet Holder constants are calculated and linearly interpolated in a series of images, the target is detected by testing the linearity errof The more accurate localization can be achieved using two images of the same region but with difIerent scaling parameters.The application results of this algorithm for target detection are also given, and show that this method has good performance of noise immunity. This method is also suitable for identifying specific targets in complex background.

  20. A capillary based chemiluminscent multi-target immunoassay.

    Science.gov (United States)

    Cao, Yuan-Cheng

    2015-05-01

    Renewed interest in capillary format immunoassays has lead to increasingly costly and complex approaches to preparation and readout. This study describes a simple multi-target method based on a capillary platform using horseradish peroxidase (HRP) labelled IgG to visualize an antibody antigen complex. When goat-anti-human IgG was employed as the probe and human IgG as target, the system allowed detection of target to less than 1 ng/mL using a standard detection approach. The capillaries were read visually or with a commercial grade CCD camera. Multi-target detection was demonstrated using a model system of rat-anti-mouse, goat-anti-human and mouse-anti-rat IgG. These probes were encoded to different locations in the capillary, providing a simple inexpensive approach to achieve multi-target assays. PMID:25731812