The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro

NARCIS (Netherlands)

von Lindern, M.; Zauner, W.; Mellitzer, G.; Steinlein, P.; Fritsch, G.; Huber, K.; Löwenberg, B.; Beug, H.

1999-01-01

Although erythropoietin (Epo) is essential for the production of mature red blood cells, the cooperation with other factors is required for a proper balance between progenitor proliferation and differentiation. In avian erythroid progenitors, steroid hormones cooperate with tyrosine kinase receptors

Sustained enhancement of OCTN1 transporter expression in association with hydroxyurea induced gamma-globin expression in erythroid progenitors

OpenAIRE

Walker, Aisha L.; Ofori-Acquah, Solomon

2016-01-01

The clinical benefits of hydroxyurea treatment in patients with sickle cell disease (SCD) are due largely to increased gamma-globin expression. However, mechanisms that control gamma-globin expression by hydroxyurea in erythroid progenitors are incompletely understood. Here, we investigated the role of two hydroxyurea transporters, urea transporter B (UTB) and organic cation/carnitine transporter 1 (OCTN1), in this process. Endogenous expression of both transporters peaked towards the end of ...

The role of catechol-O-methyltransferase in catechol-enhanced erythroid differentiation of K562 cells

Energy Technology Data Exchange (ETDEWEB)

Suriguga,; Li, Xiao-Fei; Li, Yang; Yu, Chun-Hong; Li, Yi-Ran; Yi, Zong-Chun, E-mail: yizc@buaa.edu.cn

2013-12-15

Catechol is widely used in pharmaceutical and chemical industries. Catechol is also one of phenolic metabolites of benzene in vivo. Our previous study showed that catechol improved erythroid differentiation potency of K562 cells, which was associated with decreased DNA methylation in erythroid specific genes. Catechol is a substrate for the catechol-O-methyltransferase (COMT)-mediated methylation. In the present study, the role of COMT in catechol-enhanced erythroid differentiation of K562 cells was investigated. Benzidine staining showed that exposure to catechol enhanced hemin-induced hemoglobin accumulation and induced mRNA expression of erythroid specific genes in K562 cells. Treatment with catechol caused a time- and concentration-dependent increase in guaiacol concentration in the medium of cultured K562 cells. When COMT expression was knocked down by COMT shRNA expression in K562 cells, the production of guaiacol significantly reduced, and the sensitivity of K562 cells to cytotoxicity of catechol significantly increased. Knockdown of COMT expression by COMT shRNA expression also eliminated catechol-enhanced erythroid differentiation of K562 cells. In addition, the pre-treatment with methyl donor S-adenosyl-L-methionine or its demethylated product S-adenosyl-L-homocysteine induced a significant increase in hemin-induced Hb synthesis in K562 cells and the mRNA expression of erythroid specific genes. These findings indicated that O-methylation catalyzed by COMT acted as detoxication of catechol and involved in catechol-enhanced erythroid differentiation of K562 cells, and the production of S-adenosyl-L-homocysteine partly explained catechol-enhanced erythroid differentiation. - Highlights: • Catechol enhanced hemin-induced hemoglobin accumulation. • COMT-catalyzed methylation acted as detoxication of catechol. • COMT involved in catechol-enhanced erythroid differentiation.

The role of catechol-O-methyltransferase in catechol-enhanced erythroid differentiation of K562 cells

International Nuclear Information System (INIS)

Suriguga,; Li, Xiao-Fei; Li, Yang; Yu, Chun-Hong; Li, Yi-Ran; Yi, Zong-Chun

2013-01-01

Catechol is widely used in pharmaceutical and chemical industries. Catechol is also one of phenolic metabolites of benzene in vivo. Our previous study showed that catechol improved erythroid differentiation potency of K562 cells, which was associated with decreased DNA methylation in erythroid specific genes. Catechol is a substrate for the catechol-O-methyltransferase (COMT)-mediated methylation. In the present study, the role of COMT in catechol-enhanced erythroid differentiation of K562 cells was investigated. Benzidine staining showed that exposure to catechol enhanced hemin-induced hemoglobin accumulation and induced mRNA expression of erythroid specific genes in K562 cells. Treatment with catechol caused a time- and concentration-dependent increase in guaiacol concentration in the medium of cultured K562 cells. When COMT expression was knocked down by COMT shRNA expression in K562 cells, the production of guaiacol significantly reduced, and the sensitivity of K562 cells to cytotoxicity of catechol significantly increased. Knockdown of COMT expression by COMT shRNA expression also eliminated catechol-enhanced erythroid differentiation of K562 cells. In addition, the pre-treatment with methyl donor S-adenosyl-L-methionine or its demethylated product S-adenosyl-L-homocysteine induced a significant increase in hemin-induced Hb synthesis in K562 cells and the mRNA expression of erythroid specific genes. These findings indicated that O-methylation catalyzed by COMT acted as detoxication of catechol and involved in catechol-enhanced erythroid differentiation of K562 cells, and the production of S-adenosyl-L-homocysteine partly explained catechol-enhanced erythroid differentiation. - Highlights: • Catechol enhanced hemin-induced hemoglobin accumulation. • COMT-catalyzed methylation acted as detoxication of catechol. • COMT involved in catechol-enhanced erythroid differentiation

The role of catechol-O-methyltransferase in catechol-enhanced erythroid differentiation of K562 cells.

Science.gov (United States)

Suriguga; Li, Xiao-Fei; Li, Yang; Yu, Chun-Hong; Li, Yi-Ran; Yi, Zong-Chun

2013-12-15

Catechol is widely used in pharmaceutical and chemical industries. Catechol is also one of phenolic metabolites of benzene in vivo. Our previous study showed that catechol improved erythroid differentiation potency of K562 cells, which was associated with decreased DNA methylation in erythroid specific genes. Catechol is a substrate for the catechol-O-methyltransferase (COMT)-mediated methylation. In the present study, the role of COMT in catechol-enhanced erythroid differentiation of K562 cells was investigated. Benzidine staining showed that exposure to catechol enhanced hemin-induced hemoglobin accumulation and induced mRNA expression of erythroid specific genes in K562 cells. Treatment with catechol caused a time- and concentration-dependent increase in guaiacol concentration in the medium of cultured K562 cells. When COMT expression was knocked down by COMT shRNA expression in K562 cells, the production of guaiacol significantly reduced, and the sensitivity of K562 cells to cytotoxicity of catechol significantly increased. Knockdown of COMT expression by COMT shRNA expression also eliminated catechol-enhanced erythroid differentiation of K562 cells. In addition, the pre-treatment with methyl donor S-adenosyl-L-methionine or its demethylated product S-adenosyl-L-homocysteine induced a significant increase in hemin-induced Hb synthesis in K562 cells and the mRNA expression of erythroid specific genes. These findings indicated that O-methylation catalyzed by COMT acted as detoxication of catechol and involved in catechol-enhanced erythroid differentiation of K562 cells, and the production of S-adenosyl-L-homocysteine partly explained catechol-enhanced erythroid differentiation. © 2013.

Enhancement of erythroid colony growth in culture by hemin

International Nuclear Information System (INIS)

Porter, P.N.; Meints, R.H.; Mesner, K.

1979-01-01

Hemin was found to enhance the growth of murine erythroid colonies in culture. In the presence of 100 mU/ml erythropoietin (EPO), the addition of hemin (0.05-0.2 mM) resulted in the growth of twice as many colonies as were obtained with EPO alone. Hemin also significantly increased erythroid colony formation in culture in the absence of added EPO. Hemoblobin synthesis as measured by the incorporation of 59 Fe into cyclohexanone extractable heme was augmented in culture by hemin. Neither Δ-aminolevulinic acid, a hemin precursor, nor FeCl 3 increased colony number. (author)

Pedagogies to Achieve Sustainability Learning Outcomes in Civil and Environmental Engineering Students

Directory of Open Access Journals (Sweden)

Angela R. Bielefeldt

2013-10-01

Full Text Available The civil and environmental engineering disciplines have identified the levels of knowledge about sustainability that are desirable for students to achieve as they graduate with a bachelor’s degree, as well as sustainability-related competencies to be obtained during a master’s degree, and on-the-job, prior to professional licensure. Different pedagogies are better suited to help students attain these levels of cognitive ability, while also developing affective outcomes. This paper provides examples of different methods that have been used at one institution to educate engineering students about sustainability, supported with data that indicates whether the method successfully achieved the targeted learning outcomes. Lectures, in-class active learning, readings, and appropriately targeted homework assignments can achieve basic sustainability knowledge and comprehension by requiring students to define, identify, and explain aspects of sustainability. Case studies and the application of software tools are good methods to achieve application and analysis competencies. Project-based learning (PBL and project-based service-learning (PBSL design projects can reach the synthesis level and may also develop affective outcomes related to sustainability. The results provide examples that may apply to a wider range of disciplines and suggest sustainability outcomes that are particularly difficult to teach and/or assess.

Achieving Sustainability: Insights from Biogas Ecosystems in India

Directory of Open Access Journals (Sweden)

Gita Surie

2017-02-01

Full Text Available This paper focuses on how the use of renewable energy technologies such as biogas can help to achieve environmental and socio-economic sustainability. It combines research on sustainable consumption and production, natural and industrial ecosystems and renewable energy adoption to develop a framework for an industrial ecosystem for biogas for bottom-of-the-pyramid and rural populations. The framework suggests that three dimensions of industrial ecosystems and a meta-dimension can be embedded in the design of a new industrial ecosystem for biogas to facilitate environmental and socio-economic sustainability. Case studies of an organization engaged in using biogas to create a sustainable bioenergy ecosystem for rural populations and two organizations producing biogas in urban India provide support for the framework.

Measures For Achieving Sustainable Rabbit Production In ...

African Journals Online (AJOL)

A study was conducted to ascertain ways of achieving sustainable rabbits production in Ogba/Egbema/Ndoni Local Government Area of Rivers State. The study population involved 120 respondents comprising 40 students and 80 farmers. Two sets of structured questionnaire designed with a 4-point Likert type rating scale ...

Erythroid differentiation of fetal, newborn and adult haemopoietic stem cells

International Nuclear Information System (INIS)

Rencricca, N.J.; Howard, D.; Kubanek, B.; Stohlman, F.; Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA)

1976-01-01

Erythroid regeneration was studied in lethally irradiated mice given transplants containing equivalent numbers of haemopoietic stem cells (i.e. CFU) from fetal liver, neonatal marrow or adult marrow. Adult marrow was taken from normal control mice, whose CFU for the most part were not in active cell cycle, as well as from phenylhydrazine-treated groups whose CFU were in similar state of proliferation (i.e. approximately 40-50% in DNA synthesis) as those derived from fetal liver and neonatal marrow. Splenic and femoral radioiron ( 59 Fe) incorporation were measured at intervals after transplantation and were found to begin earliest in mice given fetal liver, then in animals given neonatal marrow and latest in recipients of adult marrow. Peripheral reticulocytes showed a similar pattern of recovery. The data reported herein suggest that the differences in erythroid regeneration evoked by transplants of fetal liver, neonatal marrow or adult marrow, are not solely attributed to the degree of proliferation in the pluripotential stem cell compartment. These data may, however, suggest a shorter doubling time for cells comprising the fetal and newborn committed erythroid compartments. (author)

Erythroid differentiation of fetal, newborn, and adult haemopoietic stem cells

Energy Technology Data Exchange (ETDEWEB)

Rencricca, N J; Howard, D; Kubanek, B; Stohlman, F [Boston Univ., Mass. (USA). School of Medicine; Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA)

1976-01-01

Erythroid regeneration was studied in lethally irradiated mice given transplants containing equivalent numbers of haemopoietic stem cells (i.e. CFU) from fetal liver, neonatal marrow or adult marrow. Adult marrow was taken from normal control mice, whose CFU for the most part were not in active cell cycle, as well as from phenylhydrazine-treated groups whose CFU were in similar state of proliferation (i.e. approximately 40-50% in DNA synthesis) as those derived from fetal liver and neonatal marrow. Splenic and femoral radioiron (/sup 59/Fe) incorporation were measured at intervals after transplantation and were found to begin earliest in mice given fetal liver, then in animals given neonatal marrow and latest in recipients of adult marrow. Peripheral reticulocytes showed a similar pattern of recovery. The data reported herein suggest that the differences in erythroid regeneration evoked by transplants of fetal liver, neonatal marrow or adult marrow, are not solely attributed to the degree of proliferation in the pluripotential stem cell compartment. These data may, however, suggest a shorter doubling time for cells comprising the fetal and newborn committed erythroid compartments.

Unravelling pathways downstream Sox6 induction in K562 erythroid cells by proteomic analysis

KAUST Repository

Barbarani, Gloria; Ronchi, Antonella; Ruoppolo, Margherita; Santorelli, Lucia; Steinfelder, Robert; Elangovan, Sudharshan; Fugazza, Cristina; Caterino, Marianna

2017-01-01

are accompanied with a reduced survival of Sox6-/- red blood cells, resulting in a compensated anemia. Sox6-overexpression in K562 cells and in human primary ex vivo erythroid cultures enhances erythroid differentiation and leads to hemoglobinization, the hallmark

Unravelling pathways downstream Sox6 induction in K562 erythroid cells by proteomic analysis

KAUST Repository

Barbarani, Gloria

2017-10-20

The Sox6 transcription factor is crucial for terminal maturation of definitive red blood cells. Sox6-null mouse fetuses present misshapen and nucleated erythrocytes, due to impaired actin assembly and cytoskeleton stability. These defects are accompanied with a reduced survival of Sox6-/- red blood cells, resulting in a compensated anemia. Sox6-overexpression in K562 cells and in human primary ex vivo erythroid cultures enhances erythroid differentiation and leads to hemoglobinization, the hallmark of erythroid maturation. To obtain an overview on processes downstream to Sox6 expression, we performed a differential proteomic analysis on human erythroid K562 cells overexpressing Sox6. Sox6-overexpression induces dysregulation of 64 proteins, involved in cytoskeleton remodeling and in protein synthesis, folding and trafficking, key processes for erythroid maturation. Moreover, 43 out of 64 genes encoding for differentially expressed proteins contain within their proximal regulatory regions sites that are bound by SOX6 according to ENCODE ChIP-seq datasets and are possible direct SOX6 targets. SAR1B, one of the most induced proteins upon Sox6 overexpression, shares a conserved regulatory module, composed by a double SOX6 binding site and a GATA1 consensus, with the adjacent SEC24 A gene. Since both genes encode for COPII components, this element could concur to the coordinated expression of these proteins during erythropoiesis.

Bmi-1 Regulates Extensive Erythroid Self-Renewal

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Ah Ram Kim

2015-06-01

Full Text Available Red blood cells (RBCs, responsible for oxygen delivery and carbon dioxide exchange, are essential for our well-being. Alternative RBC sources are needed to meet the increased demand for RBC transfusions projected to occur as our population ages. We previously have discovered that erythroblasts derived from the early mouse embryo can self-renew extensively ex vivo for many months. To better understand the mechanisms regulating extensive erythroid self-renewal, global gene expression data sets from self-renewing and differentiating erythroblasts were analyzed and revealed the differential expression of Bmi-1. Bmi-1 overexpression conferred extensive self-renewal capacity upon adult bone-marrow-derived self-renewing erythroblasts, which normally have limited proliferative potential. Importantly, Bmi-1 transduction did not interfere with the ability of extensively self-renewing erythroblasts (ESREs to terminally mature either in vitro or in vivo. Bmi-1-induced ESREs can serve to generate in vitro models of erythroid-intrinsic disorders and ultimately may serve as a source of cultured RBCs for transfusion therapy.

Dimethyl sulfoxide-inducible cytoplasmic factor involved in erythroid differentiation in mouse erythroleukemia (Friend) cells

International Nuclear Information System (INIS)

Watanabe, T.; Oishi, M.

1987-01-01

A previous report described an intracellular factor (differentiation-inducing factor I, or DIF-I) that seem to play a role in erythroid differentiation in mouse erythroleukemia (MEL) cells. The authors have detected another erythroid-inducing factor in cell-free extracts from dimethyl sulfoxide- or hexamethylenebis(acetamide)-treated MEL cells, which acts synergistically with DIF-I. The partially purified factor (termed DIF-II) triggered erythroid differentiation when introduced into undifferentiated MEL cells that had been potentiated by the induction of DIF-I. The activity in the extracts appeared in an inducible manner after addition of dimethyl sulfoxide or hexamethylenebis(acetamide), reached a maximum at 6 hr, and then rapidly decreased. The induction was inhibited by phorbol 12-myristate 13-acetate and also by cycloheximide. No induction was observed in a mutant MEL cell line defective in erythroid differentiation. These characteristics are consistent with the supposition that DIF-II is one of the putative dimethyl sulfoxide-inducible factors detected in previously reported cell-fusion and cytoplast-fusion experiments. The role of DIF-II in MEL-cell differentiation and in vitro differentiation in general is discussed

PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.

Science.gov (United States)

Ryu, Moon-Suhn; Zhang, Deliang; Protchenko, Olga; Shakoury-Elizeh, Minoo; Philpott, Caroline C

2017-05-01

Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically reactive iron. In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin. The roles of PCBP, ferritin, and NCOA4 in erythroid development remain unclear. Here, we show that PCBP1, NCOA4, and ferritin are critical for murine red cell development. Using a cultured cell model of erythroid differentiation, depletion of PCBP1 or NCOA4 impaired iron trafficking through ferritin, which resulted in reduced heme synthesis, reduced hemoglobin formation, and perturbation of erythroid regulatory systems. Mice lacking Pcbp1 exhibited microcytic anemia and activation of compensatory erythropoiesis via the regulators erythropoietin and erythroferrone. Ex vivo differentiation of erythroid precursors from Pcbp1-deficient mice confirmed defects in ferritin iron flux and heme synthesis. These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin.

Human Cord Blood and Bone Marrow CD34+ Cells Generate Macrophages That Support Erythroid Islands.

Directory of Open Access Journals (Sweden)

Eyayu Belay

Full Text Available Recently, we developed a small molecule responsive hyperactive Mpl-based Cell Growth Switch (CGS that drives erythropoiesis associated with macrophages in the absence of exogenous cytokines. Here, we compare the physical, cellular and molecular interaction between the macrophages and erythroid cells in CGS expanded CD34+ cells harvested from cord blood, marrow or G-CSF-mobilized peripheral blood. Results indicated that macrophage based erythroid islands could be generated from cord blood and marrow CD34+ cells but not from G-CSF-mobilized CD34+ cells. Additional studies suggest that the deficiency resides with the G-CSF-mobilized CD34+ derived monocytes. Gene expression and proteomics studies of the in vitro generated erythroid islands detected the expression of erythroblast macrophage protein (EMP, intercellular adhesion molecule 4 (ICAM-4, CD163 and DNASE2. 78% of the erythroblasts in contact with macrophages reached the pre reticulocyte orthochromatic stage of differentiation within 14 days of culture. The addition of conditioned medium from cultures of CD146+ marrow fibroblasts resulted in a 700-fold increase in total cell number and a 90-fold increase in erythroid cell number. This novel CD34+ cell derived erythroid island may serve as a platform to explore the molecular basis of red cell maturation and production under normal, stress and pathological conditions.

Achieving Nuclear Sustainability through Innovation

International Nuclear Information System (INIS)

2013-01-01

In 2000, the IAEA Member States recognized that concerted and coordinated research and development is needed to drive innovation that ensures that nuclear energy can help meet energy needs sustainably in the 21st century. Following an IAEA General Conference resolution, an international 'think tank' and dialogue forum were established. The resulting organization, the IAEA's International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), helps nuclear technology holders and users coordinate the national and international studies, research and other activities needed to achieve innovations in nuclear reactor designs and fuel cycles. Currently, 38 countries plus the European Commission are participating in the project. This group includes both developing and developed economies that represent more than 75% of the world's population and 85% of its gross domestic product. INPRO undertakes collaborative projects among IAEA Member States, which analyse development scenarios and examine how nuclear energy can support the United Nations' goals for sustainable development in the 21st century. The results of these projects can be applied by IAEA Member States in their national nuclear energy strategies and can lead to international cooperation resulting in beneficial innovations in nuclear energy technology and its deployment. For example, INPRO studies the 'back end' of the fuel cycle, including recycling of spent fuel to increase resource use efficiency and to reduce the waste disposal burdens.

Intelligent Buildings: Key to Achieving Total Sustainability in the Built Environment

Directory of Open Access Journals (Sweden)

Tulika Gadakari

2014-01-01

Full Text Available ‘Are intelligent buildings a pragmatic approach towards achieving a sustainable built environment?’ is the research question that this review article aims to answer. It has been argued that there is a serious need for intelligent buildings to be evaluated against the parameters of total sustainability (environmental, economic and social so as to help the agenda of living in a technologically advanced, healthy and comfortable world. This paper reviews existing theoretical concepts of intelligence and sustainability in the built environment, through an exploration of various scientific literature and U.S Green Building Council’s LEED (Leadership in Energy and Environmental Design databases. A systematic qualitative review approach has been employed to select an appropriate definition of sustainable development and use it as a theoretical framework to assess the technological impact of intelligent buildings on the environmental, economic and social front. Subsequently five case study buildings from around the world, which exemplify the use of intelligent technologies to achieve sustainable gains were chosen and analyzed to further validate the literature findings. Outputs from the study highlight the various benefits of intelligent buildings, which include decrease in energy and water consumption, operational costs, as well as increase in productivity and investments. Additionally the analysis of the case studies revealed that the use of intelligent building technologies has contributed significantly towards a higher sustainability rating on the LEED rating scale. Moreover, the comparison of the attributes of intelligent buildings and sustainable practices in buildings, illustrates the fact that there is a considerable overlap between the two and intelligence can aid sustainability in the built environment. Thus the research suggests that green technologies and intelligence in combination may be a pragmatic approach towards the sustainability

Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells.

Directory of Open Access Journals (Sweden)

Ryo Kurita

Full Text Available Transfusion of red blood cells (RBCs is a standard and indispensable therapy in current clinical practice. In vitro production of RBCs offers a potential means to overcome a shortage of transfusable RBCs in some clinical situations and also to provide a source of cells free from possible infection or contamination by microorganisms. Thus, in vitro production of RBCs may become a standard procedure in the future. We previously reported the successful establishment of immortalized mouse erythroid progenitor cell lines that were able to produce mature RBCs very efficiently. Here, we have developed a reliable protocol for establishing immortalized human erythroid progenitor cell lines that are able to produce enucleated RBCs. These immortalized cell lines produce functional hemoglobin and express erythroid-specific markers, and these markers are upregulated following induction of differentiation in vitro. Most importantly, these immortalized cell lines all produce enucleated RBCs after induction of differentiation in vitro, although the efficiency of producing enucleated RBCs remains to be improved further. To the best of our knowledge, this is the first demonstration of the feasibility of using immortalized human erythroid progenitor cell lines as an ex vivo source for production of enucleated RBCs.

Roads from Rio+20. Pathways to achieve global sustainability goals by 2050

Energy Technology Data Exchange (ETDEWEB)

Van Vuuren, D. [ed.; Kok, M. [ed.; Van der Esch, S.; Jeuken, M.; Lucas, P.; Prins, Anne-Gerdien; Alkemade, R.; Van den Berg, M.; Hilderink, H.; Kram, T.; Stehfest, E.; De Vries, B. [Netherlands Environmental Assessment Agency PBL, Den Haag (Netherlands); Biermann, F.; Van der Grijp, N.; Pattberg, P. [Institute for Environmental Studies IVM, Vrije Universiteit, Amsterdam (Netherlands); Melamed, C.; Scott, A.; Te Velde, D. W.; Wiggins, S. [Overseas Development Institute ODI, London (United Kingdom)

2012-06-15

This report analyses how combinations of technological measures and changes in consumption patterns could contribute to achieving a set of sustainability objectives, taking into account the interlinkages between them. The potential exists for achieving all of the objectives.

Sustainable intensification in agriculture as a factor of achieving food security

Directory of Open Access Journals (Sweden)

Đurić Katarina

2016-01-01

Full Text Available Ending hunger, achieving food security and promoting sustainable development are at the top of the list of United Nations sustainable global development priorities after 2015. In addition to many positive effects, efforts of mankind regarding the reduction of rural poverty realized through the Green Revolution have had many negative effects, primarily related to natural resources. Irreversible devastation of land, air and water quality deterioration and jeopardizing biodiversity have been recognized as key elements of unsustainability of existing agricultural development concept. Consequently, there is a need for the adoption of a new concept of agricultural development, which will lie between intensive conventional and organic farming. The concept which has already been applied in some regions of the world and whose basic goal is to find a way to increase production with a negligible negative impact on the environment is sustainable agricultural intensification. The aim of this paper is to look at both positive and negative aspects of biotechnology development so far and point out the place and role the sustainable intensification concept should have in relation to conservation of natural resources and achievement of food security.

THE EFFECTS OF IL-1 AND IL-4 ON THE EPO-INDEPENDENT ERYTHROID PROGENITOR IN POLYCYTHEMIA-VERA

NARCIS (Netherlands)

DEWOLF, JTM; HENDRIKS, DW; ESSELINK, MT; HALIE, MR; VELLENGA, E

1994-01-01

Human recombinant interleukin-1 (IL-1) was studied for its effects on the erythroid progenitors from normal subjects and from patients with polycythaemia vera (PV). No supportive effect of IL-1 was noticed on the normal, erythropoietin (Epo) dependent, erythroid burst-forming unit (BFU-E) using

A computer-aided approach for achieving sustainable process design by process intensification

DEFF Research Database (Denmark)

Anantasarn, Nateetorn; Suriyapraphadilok, Uthaiporn; Babi, Deenesh Kavi

2017-01-01

to generate flowsheet alternatives that satisfy the design targets thereby, minimizing and/or eliminating the process hot-spots. The application of the framework is highlighted through the production of para-xylene via toluene methylation where more sustainable flowsheet alternatives that consist of hybrid......Process intensification can be applied to achieve sustainable process design. In this paper, a systematic, 3-stage synthesis-intensification framework is applied to achieve more sustainable design. In stage 1, the synthesis stage, an objective function and design constraints are defined and a base...... case is synthesized. In stage 2, the design and analysis stage, the base case is analyzed using economic and environmental analyses to identify process hot-spots that are translated into design targets. In stage 3, the innovation design stage, phenomena-based process intensification is performed...

Holistic Performance Measurement to Achieve Sustainable Competitive Advantage

OpenAIRE

Keni Keni

2013-01-01

In the past, companies used balanced scorecard to measure its performance. Now, balanced scorecard as a performance measurement tool is no longer sufficient because business has been affected by changes to the natural environment and developing social expectations. In order to achieve sustainable competitive advantage, companies are beginning to address the risks and opportunities associated with these changes in their longer-term business planning. To turn risks into opportunities, companies...

Hypoxia-inducible factor 1-mediated human GATA1 induction promotes erythroid differentiation under hypoxic conditions.

Science.gov (United States)

Zhang, Feng-Lin; Shen, Guo-Min; Liu, Xiao-Ling; Wang, Fang; Zhao, Ying-Ze; Zhang, Jun-Wu

2012-08-01

Hypoxia-inducible factor promotes erythropoiesis through coordinated cell type-specific hypoxia responses. GATA1 is essential to normal erythropoiesis and plays a crucial role in erythroid differentiation. In this study, we show that hypoxia-induced GATA1 expression is mediated by HIF1 in erythroid cells. Under hypoxic conditions, significantly increased GATA1 mRNA and protein levels were detected in K562 cells and erythroid induction cultures of CD34(+) haematopoietic stem/progenitor cells. Enforced HIF1α expression increased GATA1 expression, while HIF1α knockdown by RNA interference decreased GATA1 expression. In silico analysis revealed one potential hypoxia response element (HRE). The results from reporter gene and mutation analysis suggested that this element is necessary for hypoxic response. Chromatin immunoprecipitation (ChIP)-PCR showed that the putative HRE was recognized and bound by HIF1 in vivo. These results demonstrate that the up-regulation of GATA1 during hypoxia is directly mediated by HIF1.The mRNA expression of some erythroid differentiation markers was increased under hypoxic conditions, but decreased with RNA interference of HIF1α or GATA1. Flow cytometry analysis also indicated that hypoxia, desferrioxamine or CoCl(2) induced expression of erythroid surface markers CD71 and CD235a, while expression repression of HIF1α or GATA1 by RNA interference led to a decreased expression of CD235a. These results suggested that HIF1-mediated GATA1 up-regulation promotes erythropoiesis in order to satisfy the needs of an organism under hypoxic conditions. © 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.

Towards Intelligently - Sustainable Cities? From Intelligent and Knowledge City Programmes to the Achievement of Urban Sustainability

NARCIS (Netherlands)

Gargiulo Morelli, V.; Weijnen, M.P.C.; Van Bueren, E.M.; Wenzler, I.; De Reuver, G.A.; Salvati, L.

2013-01-01

In the quest for achieving sustainable cities, Intelligent and Knowledge City Programmes (ICPs and KCPs) represent cost-efficient strategies for improving the overall performance of urban systems, especially when compared with the costs of physical restructuring and/or retrofitting projects.

Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome.

Science.gov (United States)

Zheng, Qing-Qing; Zhao, You-Shan; Guo, Juan; Zhao, Si-da; Song, Lu-Xi; Fei, Cheng-Ming; Zhang, Zheng; Li, Xiao; Chang, Chun-Kang

2017-07-01

Erythroid apoptosis increases significantly in myelodysplastic syndrome (MDS) patients with iron overload, but the underlying mechanism is not fully clear. In this study, we aim to explore the effect of HIF-1a/ROS on erythroid apoptosis in MDS patients with iron overload. We found that iron overload injured cellular functions through up-regulating ROS levels in MDS/AML cells, including inhibited cell viability, increased cell apoptosis and blocked cell cycle at G0/G1 phase. Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells. And gene knockdown of HIF-1a got the similar results as iron overload in MDS/AML cells. Furthermore, iron overload caused high erythroid apoptosis was closely related with ROS in MDS patients. Importantly, the HIF-1a protein levels of erythrocytes elevated obviously after incubation with desferrioxamine (DFO) from MDS patients with iron overload, accompanied by ROS levels inhibited and erythroid apoptosis reduced. Taken together, our findings determine that the HIF-1a/ROS signaling pathway plays a key role in promoting erythroid apoptosis in MDS patients with iron overload. Copyright © 2017 Elsevier Ltd. All rights reserved.

Polyherbal EMSA ERITIN Promotes Erythroid Lineages and Lymphocyte Migration in Irradiated Mice

Directory of Open Access Journals (Sweden)

Ibrahim Mansur

2016-01-01

Full Text Available Radiotherapy is commonly used to kill malignant cells, but it can significantly deplete hematopoietic and splenic erythroblasts. Radioprotective agents are therefore very important in clinical radiotherapy. We examined the effect of poly-herbal EMSA ERITIN on immunological responses when administered to sublethally irradiated mice with the aim of highlighting promotes erythroid lineages and lymphocytes migration in irradiated mice with the parameter are TER119+CD123+in bone marrow and SDF-1 in bone marrow and spleen organ. Normal BALB/c mice were sublethally irradiated with 600 rad. EMSA ERITIN was administered orally at different doses:(1.04, 3.125 and 9.375 mg/g body weight for 15 days. On day 16 erythroid lineages (TER-119+CD123+ were observed in bone marrow and lymphocytes migration by the production of SDF-1 in spleen and bone marrow. Lymphocytes migration was indicated by the production of SDF-1 in spleen and bone marrow using flow cytometry analysis. EMSA ERITIN increased the generation of erythroid lineage cells marked by TER119+CD123+ and promoted lymphocyte migration by increasing SDF-1 production in bone marrow and spleen. EMSA ERITIN appears to be a powerful medicinal herb with potential as a food supplement to normalize homeostasis and erythropoiesis after radiation.

How to achieve a sustainable future for Europe?

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Blinc Robert

2008-01-01

Full Text Available According to the Lisbon declaration from 2000 the goal of European Union is to become by 2010 the most competitive and dynamic knowledge-driven economy and by 2025 a sustainable knowledge society. The EU however faces some strong challenges on the road toward these goals and is evidently lagging behind both USA and Japan. Our analysis is based on six dimensions of these challenges, including the economic challenge, the demographic challenge, the scientific challenge, the challenge of higher education, the challenge of European governance and identity/system of values, and the environmental/ecotechnological challenge. We argue that if we are to provide a sustainable secure environment and prosperity for next generations, we have to act now at least with developments in particular in the direction of clean, cheap, and renewable energy sources with an emphasis on basic, curiosity driven research which through scientific breakthroughs, is the only realistic solution to solving world's energy requirements. Such an action could for example facilitate the transition from fossil fuels to solar power in a relatively short time of about two decades, and help EU achieve its declared sustainability targets.

Challenges, responses and partnership for achieving sustainable tourism and heritage preservation

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Maksin Marija

2010-01-01

Full Text Available The process of globalization has created the situation where the expectations of tourists are the same both with respect to the quality of services in all destinations and with respect to the authencity based on local attractions and experiences, which should be unique and different for each destination. The key element in maintaining destination attractiveness is the protection and presentation of natural and cultural heritage and its sustainable utilization for tourism development. The sustainability concept is of equal importance for long-term tourism development, destination competitiveness and heritage protection. The paper deals with the main challenges to achieving sustainable tourism and points to some key responses to them. Participation, cooperation and partnership should be a vital prerequisite for the implementation and performance of sustainable tourism and heritage protection. This attitude has been tested on several examples of good practice in heritage protection and the sustainable development of tourism destinations in Serbia. .

Dexamethasone targeted directly to macrophages induces macrophage niches that promote erythroid expansion

DEFF Research Database (Denmark)

Falchi, Mario; Varricchio, Lilian; Martelli, Fabrizio

2015-01-01

Cultures of human CD34(pos) cells stimulated with erythroid growth factors plus dexamethasone, a model for stress erythropoiesis, generate numerous erythroid cells plus a few macrophages (approx. 3%; 3:1 positive and negative for CD169). Interactions occurring between erythroblasts and macrophages...... in these cultures and the biological effects associated with these interactions were documented by live phase-contrast videomicroscopy. Macrophages expressed high motility interacting with hundreds/thousands of erythroblasts per hour. CD169(pos) macrophages established multiple rapid 'loose' interactions...... with proerythroblasts leading to formation of transient erythroblastic island-like structures. By contrast, CD169(neg) macrophages established 'tight' interactions with mature erythroblasts and phagocytosed these cells. 'Loose' interactions of CD169(pos) macrophages were associated with proerythroblast cytokinesis (the...

Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin.

Science.gov (United States)

Dorn, Isabel; Klich, Katharina; Arauzo-Bravo, Marcos J; Radstaak, Martina; Santourlidis, Simeon; Ghanjati, Foued; Radke, Teja F; Psathaki, Olympia E; Hargus, Gunnar; Kramer, Jan; Einhaus, Martin; Kim, Jeong Beom; Kögler, Gesine; Wernet, Peter; Schöler, Hans R; Schlenke, Peter; Zaehres, Holm

2015-01-01

Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells. In this context, induced pluripotent stem cells from human CD34(+) hematopoietic stem cells might be more suitable for hematopoietic differentiation than the commonly used fibroblast-derived induced pluripotent stem cells. To investigate the influence of an epigenetic memory on the ex vivo expansion of induced pluripotent stem cells into erythroid cells, we compared induced pluripotent stem cells from human neural stem cells and human cord blood-derived CD34(+) hematopoietic stem cells and evaluated their potential for differentiation into hematopoietic progenitor and mature red blood cells. Although genome-wide DNA methylation profiling at all promoter regions demonstrates that the epigenetic memory of induced pluripotent stem cells is influenced by the somatic cell type of origin of the stem cells, we found a similar hematopoietic induction potential and erythroid differentiation pattern of induced pluripotent stem cells of different somatic cell origin. All human induced pluripotent stem cell lines showed terminal maturation into normoblasts and enucleated reticulocytes, producing predominantly fetal hemoglobin. Differences were only observed in the growth rate of erythroid cells, which was slightly higher in the induced pluripotent stem cells derived from CD34(+) hematopoietic stem cells. More detailed methylation analysis of the hematopoietic and erythroid promoters identified similar CpG methylation levels in the induced pluripotent stem cell lines derived from CD34(+) cells and those derived from neural stem cells, which confirms their comparable erythroid differentiation potential. Copyright© Ferrata Storti Foundation.

Probing Conformational Stability and Dynamics of Erythroid and Nonerythroid Spectrin: Effects of Urea and Guanidine Hydrochloride

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Patra, Malay; Mukhopadhyay, Chaitali; Chakrabarti, Abhijit

2015-01-01

We have studied the conformational stability of the two homologous membrane skeletal proteins, the erythroid and non-erythroid spectrins, in their dimeric and tetrameric forms respectively during unfolding in the presence of urea and guanidine hydrochloride (GuHCl). Fluorescence and circular dichroism (CD) spectroscopy have been used to study the changes of intrinsic tryptophan fluorescence, anisotropy, far UV-CD and extrinsic fluorescence of bound 1-anilinonapthalene-8-sulfonic acid (ANS). Chemical unfolding of both proteins were reversible and could be described as a two state transition. The folded erythroid spectrin and non-erythroid spectrin were directly converted to unfolded monomer without formation of any intermediate. Fluorescence quenching, anisotropy, ANS binding and dynamic light scattering data suggest that in presence of low concentrations of the denaturants (up-to 1M) hydrogen bonding network and van der Waals interaction play a role inducing changes in quaternary as well as tertiary structures without complete dissociation of the subunits. This is the first report of two large worm like, multi-domain proteins obeying twofold rule which is commonly found in small globular proteins. The free energy of stabilization (ΔGu H 2 0) for the dimeric spectrin has been 20 kcal/mol lesser than the tetrameric from. PMID:25617632

Challenges to achievement of metal sustainability in our high-tech society.

Science.gov (United States)

Izatt, Reed M; Izatt, Steven R; Bruening, Ronald L; Izatt, Neil E; Moyer, Bruce A

2014-04-21

Achievement of sustainability in metal life cycles from mining of virgin ore to consumer and industrial devices to end-of-life products requires greatly increased recycling rates and improved processing of metals using conventional and green chemistry technologies. Electronic and other high-tech products containing precious, toxic, and specialty metals usually have short lifetimes and low recycling rates. Products containing these metals generally are incinerated, discarded as waste in landfills, or dismantled in informal recycling using crude and environmentally irresponsible procedures. Low recycling rates of metals coupled with increasing demand for high-tech products containing them necessitate increased mining with attendant environmental, health, energy, water, and carbon-footprint consequences. In this tutorial review, challenges to achieving metal sustainability, including projected use of urban mining, in present high-tech society are presented; health, environmental, and economic incentives for various government, industry, and public stakeholders to improve metal sustainability are discussed; a case for technical improvements, including use of molecular recognition, in selective metal separation technology, especially for metal recovery from dilute feed stocks is given; and global consequences of continuing on the present path are examined.

Human primary erythroid cells as a more sensitive alternative in vitro hematological model for nanotoxicity studies: Toxicological effects of silver nanoparticles.

Science.gov (United States)

Rujanapun, Narawadee; Aueviriyavit, Sasitorn; Boonrungsiman, Suwimon; Rosena, Apiwan; Phummiratch, Duangkamol; Riolueang, Suchada; Chalaow, Nipon; Viprakasit, Vip; Maniratanachote, Rawiwan

2015-12-01

Although immortalized cells established from cancerous cells have been widely used for studies in nanotoxicology studies, the reliability of the results derived from immortalized cells has been questioned because of their different characteristics from normal cells. In the present study, human primary erythroid cells in liquid culture were used as an in vitro hematological cell model for investigation of the nanotoxicity of silver nanoparticles (AgNPs) and comparing the results to the immortalized hematological cell lines HL60 and K562. The AgNPs caused significant cytotoxic effects in the primary erythroid cells, as shown by the decreased cell viability and induction of intracellular ROS generation and apoptosis, whereas they showed much lower cytotoxic and apoptotic effects in HL60 and K562 cells and did not induced ROS generation in these cell lines. Scanning electron microcopy revealed an interaction of AgNPs to the cell membrane in both primary erythroid and immortalized cells. In addition, AgNPs induced hemolysis in the primary erythroid cells in a dose-dependent manner, and transmission electron microcopy analysis revealed that AgNPs damaged the erythroid cell membrane. Taken together, these results suggest that human primary erythroid cells in liquid culture are a more sensitive alternative in vitro hematological model for nanotoxicology studies. Copyright © 2015 Elsevier B.V. All rights reserved.

Sustainable Development is the only path to achieve the green economy

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Ahmed Abou Elseoud

2015-12-01

Full Text Available Sustainable development is the management of renewable resources for the good of the entire human and natural community. Built into this concept is an awareness of the animal and plant life of the surrounding environment .The goal of sustainable development is to provide resources for the use of present populations without compromising the availability of those resources for future generations, and without causing environmental damage that challenges the survival of natural ecosystems. Consequently, sustainable economies cannot be based on the use of non-renewable resources. Ultimately, sustainable economies must be supported by the use of renewable resources such as biological productivity, and solar, wind, geothermal, and biomass energy sources. However, even renewable resources may be subjected to overexploitation and other types of environmental degradation. Central to the notion of sustainable development is the requirement that renewable resources are utilized in ways that do not diminish their capacity for renewal, so that they will always be present to sustain future generations of humans. On the other hand, Egypt welcomes the concept of the green economy to achieve sustainable development ,within the framework of respect for national priorities of each country, in order to achieve more decent work opportunities, and developments continued, and use environmental resources. Egypt have passed already in the implementation of a number of pilot projects in this regard, and look forward to witnessing the next stage for more cooperation with development. The energy is the main driver of economic and social development with the necessity to development of primary energy resources and the proper management and use of the most important policies and development strategies Egypt depends in achieving economic development and technological several sources of energy available to a power and petroleum and natural gas, but that recently Egypt has seen

Enhanced inhibition of parvovirus B19 replication by cidofovir in extendedly exposed erythroid progenitor cells.

Science.gov (United States)

Bonvicini, Francesca; Bua, Gloria; Manaresi, Elisabetta; Gallinella, Giorgio

2016-07-15

Human parvovirus B19 (B19V) commonly induces self-limiting infections but can also cause severe clinical manifestations in patients with underlying haematological disorders or with immune system deficits. Currently, therapeutic options for B19V entirely rely on symptomatic and supportive treatments since a specific antiviral therapy is not yet available. Recently a first step in the research for active compounds inhibiting B19V replication has allowed identifying the acyclic nucleoside phosphonate cidofovir (CDV). Herein, the effect of CDV against B19V replication was characterized in human erythroid progenitor cells (EPCs) cultured and infected following different experimental approaches to replicate in vitro the infection of an expanding erythroid cell population in the bone marrow. B19V replication was selectively inhibited both in infected EPCs extendedly exposed to CDV 500μM (viral inhibition 82%) and in serially infected EPCs cultures with passage of the virus progeny, constantly under drug exposure (viral inhibition 99%). In addition, a potent inhibitory effect against B19V (viral inhibition 92%) was assessed in a short-term infection of EPCs treated with CDV 500μM 1day before viral infection. In the evaluated experimental conditions, the enhanced effect of CDV against B19V might be ascribed both to the increased intracellular drug concentration achieved by extended exposure, and to a progressive reduction in efficiency of the replicative process within treated EPCs population. Copyright © 2016 Elsevier B.V. All rights reserved.

MARKETING PROGRAMS FOR GREEN PRODUCTS IN ACHIEVING ECOLOGICAL SUSTAINABILITY

OpenAIRE

Gabriela CĂPĂȚÎNĂ; Roxana-Denisa STOENESCU

2015-01-01

This article explores one dimension of green marketing programs: their potential application as a solution in achieving and maintaining the ecological sustainability on global market. We examine the necessity to develop and launch green products which can respond to environment degradation as a treatment against this phenomenon. This paper is structured in three sections: the first section is related to a clear delimitation and a better understanding of terms; the second one is an overvi...

Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system

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Deepti Jain

2015-06-01

Full Text Available During the maturation phase of mammalian erythroid differentiation, highly proliferative cells committed to the erythroid lineage undergo dramatic changes in morphology and function to produce circulating, enucleated erythrocytes. These changes are caused by equally dramatic alterations in gene expression, which in turn are driven by changes in the abundance and binding patterns of transcription factors such as GATA1. We have studied the dynamics of GATA1 binding by ChIP-seq and the global expression responses by RNA-seq in a GATA1-dependent mouse cell line model for erythroid maturation, in both cases examining seven progressive stages during differentiation. Analyses of these data should provide insights both into mechanisms of regulation (early versus late targets and the consequences in cell physiology (e.g., distinctive categories of genes regulated at progressive stages of differentiation. The data are deposited in the Gene Expression Omnibus, series GSE36029, GSE40522, GSE49847, and GSE51338.

A Rare Case of Pure Erythroid Sarcoma in a Pediatric Patient: Case Report and Literature Review

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Pablo Manresa

2017-12-01

Full Text Available We describe an exceptional case of erythroid sarcoma in a pediatric patient as a growing orbital mass with no evidence of morphologic bone marrow involvement, who was finally diagnosed of pure erythroid sarcoma based on histopathology and flow cytometry criteria. We discuss the contribution of standardized eight-color flow cytometry as a rapid and reliable diagnostic method. The use of normal bone marrow databases allowed us to identify small aberrant populations in bone marrow and later confirm the diagnosis in the neoplastic tissue.

MiR-27a Promotes Hemin-Induced Erythroid Differentiation of K562 Cells by Targeting CDC25B

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Dongsheng Wang

2018-03-01

Full Text Available Background/Aims: MicroRNAs (miRNAs play a crucial role in erythropoiesis. MiR-23a∼27a∼24-2 clusters have been proven to take part in erythropoiesis via some proteins. CDC25B (cell division control Cdc2 phosphostase B is also the target of mir-27a; whether it regulates erythropoiesis and its mechanism are unknown. Methods: To evaluate the potential role of miR-27a during erythroid differentiation, we performed miR-27a gain- and loss-of-function experiments on hemin-induced K562 cells. We detected miR-27a expression after hemin stimulation at different time points. At the same time, the γ-globin gene also was measured via real-time PCR. According to the results of the chips, we screened the target protein of miR-27a through a dual-luciferase reporter assay and identified it via Western blot analyses. To evaluate the function of CDC25B, benzidine staining and flow cytometry were employed to detect the cell differentiation and cell cycle. Results: We found that miR-27a promotes hemin-induced erythroid differentiation of human K562 cells by targeting cell division cycle 25 B (CDC25B. Overexpression of miR-27a promotes the differentiation of hemin-induced K562 cells, as demonstrated by γ-globin overexpression. The inhibition of miR-27a expression suppresses erythroid differentiation, thus leading to a reduction in the γ-globin gene. CDC25B was identified as a new target of miR-27a during erythroid differentiation. Overexpression of miR-27a led to decreased CDC25B expression after hemin treatment, and CDC25B was up-regulated when miR-27a expression was inhibited. Moreover, the inhibition of CDC25B affected erythroid differentiation, as assessed by γ-globin expression. Conclusion: This study is the first report of the interaction between miR-27a and CDC25B, and it improves the understanding of miRNA functions during erythroid differentiation.

A common signaling pathway is activated in erythroid cells expressing high levels of fetal hemoglobin: a potential role for cAMP-elevating agents in β-globin disorders

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Ikuta T

2013-12-01

Full Text Available Tohru Ikuta,1 Yuichi Kuroyanagi,1 Nadine Odo,1 Siyang Liu21Department of Anesthesiology and Perioperative Medicine, 2Department of Physiology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USABackground: Although erythroid cells prepared from fetal liver, cord blood, or blood from β-thalassemia patients are known to express fetal hemoglobin at high levels, the underlying mechanisms remain elusive. We previously showed that cyclic nucleotides such as cAMP and cGMP induce fetal hemoglobin expression in primary erythroid cells. Here we report that cAMP signaling contributes to high-level fetal hemoglobin expression in erythroid cells prepared from cord blood and β-thalassemia.Methods: The status of the cAMP signaling pathway was investigated using primary erythroid cells prepared from cord blood and the mononuclear cells of patients with β-thalassemia; erythroid cells from adult bone marrow mononuclear cells served as the control.Results: We found that intracellular cAMP levels were higher in erythroid cells from cord blood and β-thalassemia than from adult bone marrow. Protein kinase A activity levels and cAMP-response element binding protein phosphorylation were higher in erythroid cells from cord blood or β-thalassemia than in adult bone marrow progenitors. Mitogen-activated protein kinase pathways, which play a role in fetal hemoglobin expression, were not consistently activated in cord blood or β-thalassemia erythroid cells. When cAMP signaling was activated in adult erythroid cells, fetal hemoglobin was induced at high levels and associated with reduced expression of BCL11A, a silencer of the β-globin gene.Conclusion: These results suggest that activated cAMP signaling may be a common mechanism among erythroid cells with high fetal hemoglobin levels, in part because of downregulation of BCL11A. Activation of the cAMP signaling pathway with cAMP-elevating agents may prove to be an important signaling mechanism to

Carbon monoxide induced erythroid differentiation of K562 cells mimics the central macrophage milieu in erythroblastic islands.

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Shlomi Toobiak

Full Text Available Growing evidence supports the role of erythroblastic islands (EI as microenvironmental niches within bone marrow (BM, where cell-cell attachments are suggested as crucial for erythroid maturation. The inducible form of the enzyme heme oxygenase, HO-1, which conducts heme degradation, is absent in erythroblasts where hemoglobin (Hb is synthesized. Yet, the central macrophage, which retains high HO-1 activity, might be suitable to take over degradation of extra, harmful, Hb heme. Of these enzymatic products, only the hydrophobic gas molecule--CO can transfer from the macrophage to surrounding erythroblasts directly via their tightly attached membranes in the terminal differentiation stage.Based on the above, the study hypothesized CO to have a role in erythroid maturation. Thus, the effect of CO gas as a potential erythroid differentiation inducer on the common model for erythroid progenitors, K562 cells, was explored. Cells were kept under oxygen lacking environment to mimic BM conditions. Nitrogen anaerobic atmosphere (N₂A served as control for CO atmosphere (COA. Under both atmospheres cells proliferation ceased: in N₂A due to cell death, while in COA as a result of erythroid differentiation. Maturation was evaluated by increased glycophorin A expression and Hb concentration. Addition of 1%CO only to N₂A, was adequate for maintaining cell viability. Yet, the average Hb concentration was low as compared to COA. This was validated to be the outcome of diversified maturation stages of the progenitor's population.In fact, the above scenario mimics the in vivo EI conditions, where at any given moment only a minute portion of the progenitors proceeds into terminal differentiation. Hence, this model might provide a basis for further molecular investigations of the EI structure/function relationship.

Configurational Paths to Social Performance in SMEs: The Interplay of Innovation, Sustainability, Resources and Achievement Motivation

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Sascha Kraus

2017-10-01

Full Text Available In today’s world of increasing ecological, social and economic issues, the question as to how businesses can become a vehicle towards more sustainable development has become more relevant than ever. Crucial to a more sustainable economy is the successful implementation of sustainable practices through entrepreneurial activities. Although there are attempts to describe how sustainable entrepreneurs differentiate themselves, the question of how some entrepreneurs manage to successfully create a sustainable enterprise, while others do not, remains unanswered. The aim of this research is to find causal patterns that explain the success of sustainable entrepreneurs, using their social performance as a measure. Using a configuration approach-based fuzzy set qualitative comparative analysis (fsQCA of 598 Austrian small- and medium-sized enterprises (SMEs, we could identify four different combinations of the interconnected variables of innovation orientation, environmental sustainability, resource leveraging and achievement motivation, which all lead to social performance depending on the respective networking intensity of the firms. The only variable that is included in all combinations is environmental sustainability, thus indicating it may be either crucial to or a prerequisite for achieving social performance in SMEs.

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

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Zita Garate

2015-12-01

Full Text Available Pyruvate kinase deficiency (PKD is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic imbalance causing chronic non-spherocytic hemolytic anemia, as pyruvate kinase defects impair ATP production in erythrocytes. We generated PKD induced pluripotent stem cells (PKDiPSCs from peripheral blood mononuclear cells (PB-MNCs of PKD patients by non-integrative Sendai viral vectors. PKDiPSCs were gene edited to integrate a partial codon-optimized R-type pyruvate kinase cDNA in the second intron of the PKLR gene by TALEN-mediated homologous recombination (HR. Notably, we found allele specificity of HR led by the presence of a single-nucleotide polymorphism. High numbers of erythroid cells derived from gene-edited PKDiPSCs showed correction of the energetic imbalance, providing an approach to correct metabolic erythroid diseases and demonstrating the practicality of this approach to generate the large cell numbers required for comprehensive biochemical and metabolic erythroid analyses.

Myelo-erythroid commitment after burn injury is under β-adrenergic control via MafB regulation.

Science.gov (United States)

Hasan, Shirin; Johnson, Nicholas B; Mosier, Michael J; Shankar, Ravi; Conrad, Peggie; Szilagyi, Andrea; Gamelli, Richard L; Muthumalaiappan, Kuzhali

2017-03-01

Severely injured burn patients receive multiple blood transfusions for anemia of critical illness despite the adverse consequences. One limiting factor to consider alternate treatment strategies is the lack of a reliable test platform to study molecular mechanisms of impaired erythropoiesis. This study illustrates how conditions resulting in a high catecholamine microenvironment such as burns can instigate myelo-erythroid reprioritization influenced by β-adrenergic stimulation leading to anemia. In a mouse model of scald burn injury, we observed, along with a threefold increase in bone marrow LSK cells (lin neg Sca1 + cKit + ), that the myeloid shift is accompanied with a significant reduction in megakaryocyte erythrocyte progenitors (MEPs). β-Blocker administration (propranolol) for 6 days after burn, not only reduced the number of LSKs and MafB + cells in multipotent progenitors, but also influenced myelo-erythroid bifurcation by increasing the MEPs and reducing the granulocyte monocyte progenitors in the bone marrow of burn mice. Furthermore, similar results were observed in burn patients' peripheral blood mononuclear cell-derived ex vivo culture system, demonstrating that commitment stage of erythropoiesis is impaired in burn patients and intervention with propranolol (nonselective β1,2-adrenergic blocker) increases MEPs. Also, MafB + cells that were significantly increased following standard burn care could be mitigated when propranolol was administered to burn patients, establishing the mechanistic regulation of erythroid commitment by myeloid regulatory transcription factor MafB. Overall, results demonstrate that β-adrenergic blockers following burn injury can redirect the hematopoietic commitment toward erythroid lineage by lowering MafB expression in multipotent progenitors and be of potential therapeutic value to increase erythropoietin responsiveness in burn patients. Copyright © 2017 the American Physiological Society.

Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells

International Nuclear Information System (INIS)

Miller, B.A.; Perrine, S.P.; Antognetti, G.; Perlmutter, D.H.; Emerson, S.G.; Sieff, C.; Faller, D.V.

1987-01-01

The effect of gamma-interferon on fetal hemoglobin synthesis by purified cord blood, fetal liver, and adult bone marrow erythroid progenitors was studied with a radioligand assay to measure hemoglobin production by BFU-E-derived erythroblasts. Coculture with recombinant gamma-interferon resulted in a significant and dose-dependent decrease in fetal hemoglobin production by neonatal and adult, but not fetal, BFU-E-derived erythroblasts. Accumulation of fetal hemoglobin by cord blood BFU-E-derived erythroblasts decreased up to 38.1% of control cultures (erythropoietin only). Synthesis of both G gamma/A gamma globin was decreased, since the G gamma/A gamma ratio was unchanged. Picograms fetal hemoglobin per cell was decreased by gamma-interferon addition, but picograms total hemoglobin was unchanged, demonstrating that a reciprocal increase in beta-globin production occurred in cultures treated with gamma-interferon. No toxic effect of gamma-interferon on colony growth was noted. The addition of gamma-interferon to cultures resulted in a decrease in the percentage of HbF produced by adult BFU-E-derived cells to 45.6% of control. Fetal hemoglobin production by cord blood, fetal liver, and adult bone marrow erythroid progenitors, was not significantly affected by the addition of recombinant GM-CSF, recombinant interleukin 1 (IL-1), recombinant IL-2, or recombinant alpha-interferon. Although fetal progenitor cells appear unable to alter their fetal hemoglobin program in response to any of the growth factors added here, the interaction of neonatal and adult erythroid progenitors with gamma-interferon results in an altered expression of globin genes

RECOMBINANT HUMAN MAST-CELL GROWTH-FACTOR SUPPORTS ERYTHROID COLONY FORMATION IN POLYCYTHEMIA-VERA IN THE PRESENCE AND ABSENCE OF ERYTHROPOIETIN AND SERUM

NARCIS (Netherlands)

MULLER, EW; DEWOLF, JTM; HENDRIKS, DW; ESSELINK, MT; HALIE, MR; VELLENGA, E

The effect of mast cell growth factor (MGF) was studied on erythropoietin (Epo)-dependent and Epo-independent (''spontaneous'') erythroid colony formation in patients with polycythemia vera (PV). MGF stimulated both Epo-dependent and Epo-independent erythroid colony formation from PV peripheral

CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.

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Laurie A Steiner

Full Text Available CTCF and cohesinSA-1 are regulatory proteins involved in a number of critical cellular processes including transcription, maintenance of chromatin domain architecture, and insulator function. To assess changes in the CTCF and cohesinSA-1 interactomes during erythropoiesis, chromatin immunoprecipitation coupled with high throughput sequencing and mRNA transcriptome analyses via RNA-seq were performed in primary human hematopoietic stem and progenitor cells (HSPC and primary human erythroid cells from single donors.Sites of CTCF and cohesinSA-1 co-occupancy were enriched in gene promoters in HSPC and erythroid cells compared to single CTCF or cohesin sites. Cell type-specific CTCF sites in erythroid cells were linked to highly expressed genes, with the opposite pattern observed in HSPCs. Chromatin domains were identified by ChIP-seq with antibodies against trimethylated lysine 27 histone H3, a modification associated with repressive chromatin. Repressive chromatin domains increased in both number and size during hematopoiesis, with many more repressive domains in erythroid cells than HSPCs. CTCF and cohesinSA-1 marked the boundaries of these repressive chromatin domains in a cell-type specific manner.These genome wide data, changes in sites of protein occupancy, chromatin architecture, and related gene expression, support the hypothesis that CTCF and cohesinSA-1 have multiple roles in the regulation of gene expression during erythropoiesis including transcriptional regulation at gene promoters and maintenance of chromatin architecture. These data from primary human erythroid cells provide a resource for studies of normal and perturbed erythropoiesis.

Fusion of ZMYND8 and RELA genes in acute erythroid leukemia

DEFF Research Database (Denmark)

Panagopoulos, Ioannis; Micci, Francesca; Thorsen, Jim

2013-01-01

Acute erythroid leukemia was diagnosed in a 4-month-old boy. Cytogenetic analysis of bone marrow (BM) cells showed a t(11;20)(p11;q11) translocation. RNA extracted from the BM was sequenced and analyzed for fusion transcripts using the software FusionMap. A ZMYND8-RELA fusion was ranked first. RT...

Parvovirus B19 integration into human CD36+ erythroid progenitor cells.

Science.gov (United States)

Janovitz, Tyler; Wong, Susan; Young, Neal S; Oliveira, Thiago; Falck-Pedersen, Erik

2017-11-01

The pathogenic autonomous human parvovirus B19 (B19V) productively infects erythroid progenitor cells (EPCs). Functional similarities between B19V nonstructural protein (NS1), a DNA binding endonuclease, and the Rep proteins of Adeno-Associated Virus (AAV) led us to hypothesize that NS1 may facilitate targeted nicking of the human genome and B19 vDNA integration. We adapted an integration capture sequencing protocol (IC-Seq) to screen B19V infected human CD36+ EPCs for viral integrants, and discovered 40,000 unique B19V integration events distributed throughout the human genome. Computational analysis of integration patterns revealed strong correlations with gene intronic regions, H3K9me3 sites, and the identification of 41 base pair consensus sequence with an octanucleotide core motif. The octanucleotide core has homology to a single region of B19V, adjacent to the P6 promoter TATA box. We present the first direct evidence that B19V infection of erythroid progenitor cells disrupts the human genome and facilitates viral DNA integration. Copyright © 2017 Elsevier Inc. All rights reserved.

MARKETING PROGRAMS FOR GREEN PRODUCTS IN ACHIEVING ECOLOGICAL SUSTAINABILITY

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Gabriela CĂPĂȚÎNĂ

2015-04-01

Full Text Available This article explores one dimension of green marketing programs: their potential application as a solution in achieving and maintaining the ecological sustainability on global market. We examine the necessity to develop and launch green products which can respond to environment degradation as a treatment against this phenomenon. This paper is structured in three sections: the first section is related to a clear delimitation and a better understanding of terms; the second one is an overview of the literature about ecological sustainability; the third section is the most relevant part of this paper because is trying to shape a framework of marketing programs for the development of green products, considering the decisions related to marketing mix elements. Even if green marketing programs make sense, current understanding of how managers can start to develop or transform their marketing efforts is far from comprehensive; therefore, this study is addressed to this knowledge gap.

Molecular pathways of early CD105-positive erythroid cells as compared with CD34-positive common precursor cells by flow cytometric cell-sorting and gene expression profiling

International Nuclear Information System (INIS)

Machherndl-Spandl, S; Suessner, S; Danzer, M; Proell, J; Gabriel, C; Lauf, J; Sylie, R; Klein, H-U; Béné, M C; Weltermann, A; Bettelheim, P

2013-01-01

Special attention has recently been drawn to the molecular network of different genes that are responsible for the development of erythroid cells. The aim of the present study was to establish in detail the immunophenotype of early erythroid cells and to compare the gene expression profile of freshly isolated early erythroid precursors with that of the CD34-positive (CD34 + ) compartment. Multiparameter flow cytometric analyses of human bone marrow mononuclear cell fractions (n=20) defined three distinct early erythroid stages. The gene expression profile of sorted early erythroid cells was analyzed by Affymetrix array technology. For 4524 genes, a differential regulation was found in CD105-positive erythroid cells as compared with the CD34 + progenitor compartment (2362 upregulated genes). A highly significant difference was observed in the expression level of genes involved in transcription, heme synthesis, iron and mitochondrial metabolism and transforming growth factor-β signaling. A comparison with recently published data showed over 1000 genes that as yet have not been reported to be upregulated in the early erythroid lineage. The gene expression level within distinct pathways could be illustrated directly by applying the Ingenuity software program. The results of gene expression analyses can be seen at the Gene Expression Omnibus repository

The Implementation of Knowledge Strategy-Based Entrepreneurial Capacity to Achieve Sustainable Competitive Advantage

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Widodo

2013-08-01

Full Text Available This study aims to develop a model of knowledge strategy-based entrepreneurial capacity to achieve sustainable competitive advantage of rurol banking in Central Java province. The sampling method is ‘‘Purposive sampling’’ by considering the characteristics of the population items, namely: operational experience for at least 5 years and representatives of each area of rurol banking in Semarang, Surakarta and Purwokerto. Then, the sample size is 150 of 251 (59.7% of top managers of rurol banking. To analyze the data in this study, it used the Structural Equation Modeling (SEM, of the, AMOS software package. The findings of this study explain that 1. The first step in promoting a sustainable competitive advantage through knowledge sharing is by prioritizing the quality of interaction, willingness and ability. 2. Efforts to improve a sustainable competitive advantage through knowledge exploitation built by knowledge sharing are by prioritizing to actively accept changes and introduction, solve problems together, use and combine new knowledge in operation. 3. Efforts to improve a sustainable competitive advantage through the knowledge exploitation built by risk-taking are by prioritizing a strong tendency for high-risk projects (with the possibility of gaining high-return, a high courage for the actions necessary to achieve the goal, having an aggressive attitude to optimize the possibility of utilizing existing potential opportunities and enjoying the challenge of the risk situation. 4. Efforts to improve a sustainable competitive advantage through knowledge exploitation built by a pro-active are by prioritizing to anticipate problem more quickly than competitors, future oriented, addressed by technology, launching product selectively and systematically search for new ideas. 5. Efforts to improve a sustainable competitive advantage through knowledge exploitation built by the innovativeness are by prioritizing the speed of developing products

Global achievements in sustainable land management

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Peter Motavalli

2013-06-01

Full Text Available Identification and development of sustainable land management is urgently required because of widespread resource degradation from poor land use practices. In addition, the world will need to increase food production to meet the nutritional needs of a growing global population without major environmental degradation. Ongoing climate change and its impacts on the environment is an additional factor to consider in identifying and developing sustainable land use practices. The objectives of this paper are to: (1 provide a background to the need for sustainable land management, (2 identify some of its major components, and (3 discuss some examples of sustainable land management systems that are being practiced around the world. Some common components of this type of management are: (1 understanding the ecology of land management, (2 maintenance or enhancement of land productivity, (3 maintenance of soil quality, (4 increased diversity for higher stability and resilience, (5 provision of economic and ecosystem service benefits for communities, and (6 social acceptability. Several examples of sustainable land management systems are discussed to illustrate the wide range of systems that have been developed around the world including agroforestry, conservation agriculture, and precision agricultural systems. Improved technology, allowing for geater environmental measurement and for improved access and sharing of information, provides opportunities to identify and develop more sustainable land management practices and systems for the future.

Erythroid cells in vitro: from developmental biology to blood transfusion products.

Science.gov (United States)

Migliaccio, Anna Rita; Whitsett, Carolyn; Migliaccio, Giovanni

2009-07-01

Red blood cells (RBCs) transfusion plays a critical role in numerous therapies. Disruption of blood collection by political unrest, natural disasters and emerging infections and implementation of restrictions on the use of erythropoiesis-stimulating agents in cancer may impact blood availability in the near future. These considerations highlight the importance of developing alternative blood products. Knowledge about the processes that control RBC production has been applied to the establishment of culture conditions allowing ex-vivo generation of RBCs in numbers close to those (2.5 x 10 cells/ml) present in a transfusion, from cord blood, donated blood units or embryonic stem cells. In addition, experimental studies demonstrate that such cells protect mice from lethal bleeding. Therefore, erythroid cells generated ex vivo may be suitable for transfusion provided they can be produced safely in adequate numbers. However, much remains to be done to translate a theoretical production of approximately 2.5 x 10 RBCs in the laboratory into a 'clinical grade production process'. This review summarizes the state-of-the-art in establishing ex-vivo culture conditions for erythroid cells and discusses the most compelling issues to be addressed to translate this progress into a clinical grade transfusion product.

Leukemic blast cell colony formation in semisolid culture with erythropoietin: a case report of acute poorly differentiated erythroid leukemia.

Science.gov (United States)

Tomonaga, M; Jinnai, I; Tagawa, M; Amenomori, T; Nishino, K; Yao, E; Nonaka, H; Kuriyama, K; Yoshida, Y; Matsuo, T

1987-02-01

The bone marrow of a patient with acute undifferentiated leukemia developed unique colonies after a 14-day culture in erythropoietin (EPO)-containing methylcellulose. The colonies consisted of 20 to 200 nonhemoglobinized large blast cells. Cytogenetic analysis of single colonies revealed hypotetraploid karyotypes with several marker chromosomes that were identical to those found in directly sampled bone marrow. The concurrently formed erythroid bursts showed only normal karyotypes. No leukemic colony formation was observed in other culture systems with either colony-stimulating activity (CSA) or phytohemagglutinin-stimulated leukocyte-conditioned medium (PHA-LCM). The leukemic colonies exhibited a complete EPO-dose dependency similar to that of the patient's normal BFU-E. Although cytochemical and immunologic marker studies of the bone marrow cells failed to clarify the cell lineage of the leukemic cells with extraordinarily large cell size, ultrastructural study revealed erythroid differentiation such as siderosome formation in the cytoplasm and ferritin particles in the rhophecytosis invaginations. These findings indicate that the patient had poorly differentiated erythroid leukemia and that some of the clonogenic cells might respond to EPO in vitro. Corresponding to this biological feature, the leukemic cells were markedly decreased in number in response to repeated RBC transfusions, and partial remission was obtained. These observations suggest that erythroid leukemia distinct from erythroleukemia (M6) with a myeloblastic component, can develop as a minor entity of human acute leukemia.

Reduction of erythroid progenitors in protein-energy malnutrition.

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Borelli, Primavera; Blatt, Solange; Pereira, Juliana; de Maurino, Beatriz Beutler; Tsujita, Maristela; de Souza, Ana Cristina; Xavier, José Guilherme; Fock, Ricardo Ambrósio

2007-02-01

Protein-energy malnutrition is a syndrome in which anaemia together with multivitamin and mineral deficiency may be present. The pathophysiological mechanisms involved have not, however, yet been completely elucidated. The aim of the present study was to evaluate the pathophysiological processes that occur in this anaemia in animals that were submitted to protein-energy malnutrition, in particular with respect to Fe concentration and the proliferative activity of haemopoietic cells. For this, histological, histochemical, cell culture and immunophenotyping techniques were used. Two-month-old male Swiss mice were submitted to protein-energy malnutrition with a low-protein diet (20 g/kg) compared with control diet (400 g/kg). When the experimental group had attained a 20 % loss of their original body weight, the animals from both groups received, intravenously, 20 IU erythropoietin every other day for 14 d. Malnourished animals showed a decrease in red blood cells, Hb concentration and reticulocytopenia, as well as severe bone marrow and splenic atrophy. The results for serum Fe, total Fe-binding capacity, transferrin and erythropoietin in malnourished animals were no different from those of the control animals. Fe reserves in the spleen, liver and bone marrow were found to be greater in the malnourished animals. The mixed colony-forming unit assays revealed a smaller production of granulocyte-macrophage colony-forming units, erythroid burst-forming units, erythroid colony-forming units and CD45, CD117, CD119 and CD71 expression in the bone marrow and spleen cells of malnourished animals. These findings suggest that, in this protein-energy malnutrition model, anaemia is not caused by Fe deficiency or erythropoietin deficiency, but is a result of ineffective erythropoiesis.

Massive splenomegaly in acute erythroid leukaemia (FAB Class-M6): an unusual presentation.

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Sherazi, Syed Furqan Haider; Butt, Zeeshan

2012-09-01

AML-M6 has a peak incidence in the seventh decade with slight male preponderance, and can also present at a younger age. The usual features are anaemia, thrombocytopenia, malaise, fatigue, easy bruising, epistaxis and petechiae. Splenomegaly may occur in 20-40 % of the cases but massive splenomegaly is rare presentation and have been only reported once in humans and once in animals. A 22 year Asian female, presented with fatigue, pallor, mild jaundice, exertional dyspnoea, epigastric pain, tender right hypochondrium and massive splenomegaly. Investigations revealed anaemia and thrombocytopenia, tear drop cells, basophilic stippling, piokilocytosis and anisochromia; increased uric acid and LDH. Abdominal ultrasound showed enlarged liver (22cm) and spleen (20cm). Bone marrow aspiration revealed 51% erythroid and 24% non-erythroid precursors, depressed leukopoeisis and megakarypoeisis. Erythroblasts were PAS and CD71 positive and also reacted to Antihaemoglobin-Antibody. This report highlights characteristic features and diagnostic criteria of erythroleukaemia, differential diagnosis of massive splenomegaly and their rare association.

Biosynthesis of heme in immature erythroid cells. The regulatory step for heme formation in the human erythron

International Nuclear Information System (INIS)

Gardner, L.C.; Cox, T.M.

1988-01-01

Heme formation in reticulocytes from rabbits and rodents is subject to end product negative feedback regulation: intracellular free heme has been shown to control acquisition of transferrin iron for heme synthesis. To identify the site of control of heme biosynthesis in the human erythron, immature erythroid cells were obtained from peripheral blood and aspirated bone marrow. After incubation with human 59Fe transferrin, 2-[14C]glycine, or 4-[14C]delta-aminolevulinate, isotopic incorporation into extracted heme was determined. Addition of cycloheximide to increase endogenous free heme, reduced incorporation of labeled glycine and iron but not delta-aminolevulinate into cell heme. Incorporation of glycine and iron was also sensitive to inhibition by exogenous hematin (Ki, 30 and 45 microM, respectively) i.e. at concentrations in the range which affect cell-free protein synthesis in reticulocyte lysates. Hematin treatment rapidly diminished incorporation of intracellular 59Fe into heme by human erythroid cells but assimilation of 4-[14C]delta-aminolevulinate into heme was insensitive to inhibition by hematin (Ki greater than 100 microM). In human reticulocytes (unlike those from rabbits), addition of ferric salicylaldehyde isonicotinoylhydrazone, to increase the pre-heme iron pool independently of the transferrin cycle, failed to promote heme synthesis or modify feedback inhibition induced by hematin. In human erythroid cells (but not rabbit reticulocytes) pre-incubation with unlabeled delta-aminolevulinate or protoporphyrin IX greatly stimulated utilization of cell 59Fe for heme synthesis and also attenuated end product inhibition. In human erythroid cells heme biosynthesis is thus primarily regulated by feedback inhibition at one or more steps which lead to delta-aminolevulinate formation

Mountain Forests and Sustainable Development: The Potential for Achieving the United Nations' 2030 Agenda

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Georg Gratzer

2017-08-01

Full Text Available The world is facing numerous and severe environmental, social, and economic challenges. To address these, in September 2015 the General Assembly of the United Nations adopted the resolution Transforming our World: The 2030 Agenda for Sustainable Development. The United Nations' 17 sustainable development goals (SDGs and their 169 targets are ambitious, broadly encompassing, and indivisible. They are intended to guide nations and communities toward attaining healthy and peaceful livelihoods free of poverty and hunger. Collectively the goals envision sound and safe environments, where global threats like climate change are successfully combated through both mitigation and adaptation. Agenda 2030 envisages sustainable production patterns with inclusive, effective economies and institutions. It is of specific relevance to mountain communities, where the population is predominantly rural and half of the rural inhabitants experience food insecurity and are often highly dependent on forest resources. Mountain forests also contribute to human welfare well beyond the local community: through functions such as climate and hydrological services provided at regional and global scales, and harvested commodities traded at multiple economic scales. In this introductory essay we argue that sustainable forest management in mountain areas disproportionately contributes to achieving the SDGs. We discuss (1 the potential of mountain forests to help achieve SDGs in mountainous regions and beyond, (2 the potential of the SDGs to help solve severe socioeconomic and ecological problems in forested mountain areas, and (3 challenges and opportunities associated with implementing the SDGs. We base our argumentation also on the 8 papers presented in this Focus Issue of Mountain Research and Development. Together, they establish a clear connection between sustainable use and protection of mountain forests and vital ecosystem services upon which many regions depend. We

Sustainable Phosphorus Measures: Strategies and Technologies for Achieving Phosphorus Security

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Stuart White

2013-01-01

Full Text Available Phosphorus underpins the world’s food systems by ensuring soil fertility, maximising crop yields, supporting farmer livelihoods and ultimately food security. Yet increasing concerns around long-term availability and accessibility of the world’s main source of phosphorus—phosphate rock, means there is a need to investigate sustainable measures to buffer the world’s food systems against the long and short-term impacts of global phosphorus scarcity. While the timeline of phosphorus scarcity is contested, there is consensus that more efficient use and recycling of phosphorus is required. While the agricultural sector will be crucial in achieving this, sustainable phosphorus measures in sectors upstream and downstream of agriculture from mine to fork will also need to be addressed. This paper presents a comprehensive classification of all potential phosphorus supply- and demand-side measures to meet long-term phosphorus needs for food production. Examples range from increasing efficiency in the agricultural and mining sector, to technologies for recovering phosphorus from urine and food waste. Such measures are often undertaken in isolation from one another rather than linked in an integrated strategy. This integrated approach will enable scientists and policy-makers to take a systematic approach when identifying potential sustainable phosphorus measures. If a systematic approach is not taken, there is a risk of inappropriate investment in research and implementation of technologies and that will not ultimately ensure sufficient access to phosphorus to produce food in the future. The paper concludes by introducing a framework to assess and compare sustainable phosphorus measures and to determine the least cost options in a given context.

Achieving Our Environmental Sustainability Goals: The Opportunities and Pitfalls of Applying Life Cycle Thinking

Science.gov (United States)

An increasing number of people around the world are beginning to realize that a systems approach, such as life cycle thinking, is necessary to truly achieve environmental sustainability. Without the holistic perspective that life cycle thinking provides, our actions risk leading ...

Erythroid differentiation and commitment in rat erythroleukemia cells with hypertonic culture conditions.

OpenAIRE

Yamaguchi, Y; Kluge, N; Ostertag, W; Furusawa, M

1981-01-01

Cell cultures of 7,12-dimethylbenz[a]anthracene-induced rat erythroleukemia can be stimulated to synthesize hemoglobin when cultured in hypertonic media. During hypertonic treatment the intracellular osmotic conditions immediately readjust to those of the extracellular medium. None of the Friend virus-induced mouse erythroleukemia cell lines was inducible for differentiation with the same hypertonic culture conditions used for rat cells. Earliest commitment to erythroid terminal differentiati...

Leveraging Smart Open Innovation for Achieving Cultural Sustainability: Learning from a New City Museum Project

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Luisa Errichiello

2018-06-01

Full Text Available In recent years, cultural sustainability has attracted increasing attention within the discourse of sustainable development and sustainable cities. Notwithstanding some effort put on conceptualizing the relationship between culture and sustainability, research on the issue is still in a pre-paradigmatic stage and related empirical studies are scant. In particular, further knowledge is required to understand not only how cultural sustainability has been addressed strategically but also implemented in practice. In this direction, research has pointed out the role of social structures (e.g., partnerships, collaborations, etc. for achieving cultural sustainability goals. However, focusing on smart cities, attention is limited to how collaborative arrangements can be leveraged within the development of new city services (e.g., smart open innovation to sustain goals of environmental, economic and social sustainability, with cultural sustainability still playing a marginal role. This paper develops a new framework linking together the strategic level and the practice level in addressing cultural sustainability and conceptualizing the role of collaborative structures in the development of smart innovation. The framework is then used as a frame of reference for analyzing the case of MuseoTorino, a new city museum realized within the smart city strategy of Turin (Italy. The analysis provides evidence of some practices adopted to leverage collaboration and stakeholders’ engagement to strategically address cultural sustainability and to realize it in practice throughout the new service development process.

Lean Transformation Guidance: Why Organizations Fail To Achieve and Sustain Excellence Through Lean Improvement

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Mohammed Hamed Ahmed

2013-06-01

Full Text Available Many companies are complaining that lean didn’t achieve their long-term goals, and the improvement impact was very short-lived. 7 out of each 10 lean projects fail as companies try to use lean like a toolkit, copying and pasting the techniques without trying to adapt the employee’s culture, manage the improvement process, sustain the results, and develop their leaders. When the Toyota production system was created, the main goal was to remove wastes from the shop floor using some lean techniques and tools. What was not clear is that this required from Toyota a long process of leadership development, and a high commitment to training and coaching their employee. A Failure to achieve and sustain the improvement is a problem of both management and leadership as well as the improper understanding of the human behavior, and the required culture to success.

Possible interaction between B1 retrotransposon-containing sequences and β(major) globin gene transcriptional activation during MEL cell erythroid differentiation.

Science.gov (United States)

Vizirianakis, Ioannis S; Tezias, Sotirios S; Amanatiadou, Elsa P; Tsiftsoglou, Asterios S

2012-01-01

Repetitive sequences consist of >50% of mammalian genomic DNAs and among these SINEs (short interspersed nuclear elements), e.g. B1 elements, account for 8% of the mouse genome. In an effort to delineate the molecular mechanism(s) involved in the blockade of the in vitro differentiation program of MEL (murine erythroleukaemia) cells by treatment with methylation inhibitors, we detected a DNA region of 559 bp in chromosome 7 located downstream of the 3'-end of the β(major) globin gene (designated B1-559) with unique characteristics. We have fully characterized this B1-559 region that includes a B1 element, several repeats of ATG initiation codons and consensus DNA-binding sites for erythroid-specific transcription factors NF-E2 (nuclear factor-erythroid-derived 2), GATA-1 and EKLF (erythroid Krüppel-like factor). Fragments derived from B1-559 incubated with nuclear extracts form protein complexes in both undifferentiated and differentiated MEL cells. Transient reporter-gene experiments in MEL and human erythroleukaemia K-562 cells with recombinant constructs containing B1-559 fragments linked to HS-2 (hypersensitive site-2) sequences of human β-globin gene LCR (locus control region) indicated potential cooperation upon erythropoiesis and globin gene expression. The possible interaction between the B1-559 region and β(major) globin gene transcriptional activation upon execution of erythroid MEL cell differentiation programme is discussed. © The Author(s) Journal compilation © 2012 Portland Press Limited

Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex.

Science.gov (United States)

Ganaie, Safder S; Zou, Wei; Xu, Peng; Deng, Xuefeng; Kleiboeker, Steve; Qiu, Jianming

2017-05-01

Productive infection of human parvovirus B19 (B19V) exhibits high tropism for burst forming unit erythroid (BFU-E) and colony forming unit erythroid (CFU-E) progenitor cells in human bone marrow and fetal liver. This exclusive restriction of the virus replication to human erythroid progenitor cells is partly due to the intracellular factors that are essential for viral DNA replication, including erythropoietin signaling. Efficient B19V replication also requires hypoxic conditions, which upregulate the signal transducer and activator of transcription 5 (STAT5) pathway, and phosphorylated STAT5 is essential for virus replication. In this study, our results revealed direct involvement of STAT5 in B19V DNA replication. Consensus STAT5-binding elements were identified adjacent to the NS1-binding element within the minimal origins of viral DNA replication in the B19V genome. Phosphorylated STAT5 specifically interacted with viral DNA replication origins both in vivo and in vitro, and was actively recruited within the viral DNA replication centers. Notably, STAT5 interacted with minichromosome maintenance (MCM) complex, suggesting that STAT5 directly facilitates viral DNA replication by recruiting the helicase complex of the cellular DNA replication machinery to viral DNA replication centers. The FDA-approved drug pimozide dephosphorylates STAT5, and it inhibited B19V replication in ex vivo expanded human erythroid progenitors. Our results demonstrated that pimozide could be a promising antiviral drug for treatment of B19V-related diseases.

Establishing and sustaining a technical program to achieve zero fuel failures

International Nuclear Information System (INIS)

Deshon, J.; Whiteside, K.; Burnham, R.

2015-01-01

In 2006, Chief Nuclear Officers (CNOs) of electric utilities operating 103 commercial reactors in the United States (U.S.) formally endorsed an initiative to achieve failure-free fuel performance by the end of 2010. This became known as the Zero-by- Ten Fuel Failure Initiative. The endorsement manifested during a meeting at the Institute of Nuclear Power Operations (INPO) while nuclear fuel performance trends were being reviewed. Declining fuel performance generated backing for the Initiative. This paper provides a brief review of some of the drivers that caused those trends, the Initiative elements designed to address them, and a review of the technical program that helped achieve, and thus far sustain, improved fuel performance. (author) Key Words: Nuclear Fuel, Fuel, Fuel Failures, Fuel Failure Initiative, Zero by Ten Initiative

Two different in vitro growth patterns for erythroid precursors in 18 patients with pure erythrocytosis

International Nuclear Information System (INIS)

Clement, S.; Eberlin, A.; Najean, Y.; Chedeville, A.

1982-01-01

Growth patterns of marrow and blood erythroid progenitors were studied in 18 cases of pure erythrocytosis using different doses of erythropoietin. 8 cases demonstrated ''spontaneous'' growth of CFU-E and blood BFU-E as observed in myeloproliferative disorders, but without an excess of circulating CFU-GM. 3 of these patients also had other symptoms of a pan-myelopathy. All these cases showed good sensitivity to 32 P myelo-suppression. 10 cases demonstrated growth patterns of erythroid progenitors similar to those observed in normal subjects, except for an excess of blood BFU-E, which suggests an abnormality of homeostatic regulation. In 5 of these cases, myelo-suppression was not effective. It is suggested that a stem cell study could differentiate patients with pure erythrocytosis due to ''autonomous'' abnormal stem cell growth from cases due to abnormal regulation factors, and that such a discrimination might be usefull for the choice of theraphy. (authors)

Vaccination ecosystem health check: achieving impact today and sustainability for tomorrow.

Science.gov (United States)

Saadatian-Elahi, Mitra; Bloom, David; Plotkin, Stanley; Picot, Valentina; Louis, Jacques; Watson, Michael

2017-01-01

Vaccination is a complex ecosystem with several components that interact with one another and with the environment. Today's vaccine ecosystem is defined by the pursuit of polio eradication, the drive to get as many of the new vaccines to as many people as possible and the research and development against immunologically challenging diseases. Despite these successes, vaccine ecosystem is facing keys issues with regard to supply/distribution and cost/profitability asymmetry that risk slowing its global growth. The conference "Vaccination ecosystem health check: achieving impact today and sustainability for tomorrow" held in Annecy-France (January 19-21, 2015) took stock of the health of today's vaccination ecosystem and its ability to reliably and sustainably supply high-quality vaccines while investing in tomorrow's needed innovation. Small and decreasing numbers of suppliers/manufacturing facilities; paucity of research-driven companies; regulatory pressures; market uncertainties; political prioritization; anti-vaccine movements/complacency; and technological and programmatic issues were acknowledged as the major challenges that could weaken today's vaccination ecosystem. The expert panel discussed also drivers and barriers to a sustainable vaccination ecosystem; the metrics of a vaccination ecosystem; and what should be added, removed, increased, or reduced to maintain the health of the vaccination ecosystem.

Identification of a human erythroid progenitor cell population which expresses the CD34 antigen and binds the plant lectin Ulex europaeus I.

Science.gov (United States)

Unverzagt, K L; Martinson, J; Lee, W; Stiff, P J; Williams, S; Bender, J G

1996-01-01

Two and three color flow cytometry of normal human bone marrow was used to identify CD34+ progenitor cells and examine their binding to the plant lectin Ulex europaeus I (Ulex). In normal bone marrow, 48.48 +/- 17.4% of the CD34+ cells bind to Ulex. Two color flow cytometry was used to sort CD34 + cells, and subsets of CD34+ cells, CD34+ Ulex+ and CD34+ Ulex-. These populations were sorted into colony assays to assess myeloid (CFU-GM) and erythroid (BFU-E) progenitors. The CD34+ Ulex+ subset was 84 +/- 14% BFU-E colonies (mean +/- S.D.) and had the highest cloning efficiency of 28 +/- 13%. Three color analysis of CD34+ Ulex+ cells showed staining with other erythroid (CD71, GlyA) antibodies and lack of stain. ing with myeloid (CD13, CD45RA) antibodies. These studies confirmed the erythroid characteristics of this subpopulation.

Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced autophagy of mitochondria

NARCIS (Netherlands)

Houwerzijl, E. J.; Pol, H-W D.; Blom, N. R.; van der Want, J. J. L.; de Wolf, J. Thm; Vellenga, E.

Recent studies in erythroid cells have shown that autophagy is an important process for the physiological clearance of mitochondria during terminal differentiation. However, autophagy also plays an important role in removing damaged and dysfunctional mitochondria. Defective mitochondria and impaired

Achieving sustainable cultivation of potatoes

Science.gov (United States)

Every phase of the production cycle impacts the sustainability of potato. Potato physiology determines how genetically encoded developmental attributes interact with local environmental conditions as modified through agricultural practice to produce a perishable crop. In this chapter we highlight ho...

What Is an Education for Sustainable Development Supposed to Achieve--A Question of What, How and Why

Science.gov (United States)

Hofman, Maria

2015-01-01

This is a theoretical article to open the discussion of what an education for sustainable development is supposed to achieve and how teachers can help students to develop skills that might be needed in order to support a sustainable future. The focus in the article will be on education. As it is an article aiming to open this kind of discussion…

A TWO CENTURY HISTORY OF PACIFIC NORTHWEST SALMON: LESSONS LEARNED FOR ACHIEVING A SUSTAINABLE FUTURE

Science.gov (United States)

Achieving ecological sustainability is a daunting challenge. In the Pacific Northwest one of the most highly visible public policy debates concerns the future of salmon populations. Throughout the Pacific Northwest, many wild salmon stocks have declined and some have disappeare...

Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.

OpenAIRE

Jaako, Pekka; Debnath, Shubhranshu; Olsson, Karin; Zhang, Y; Flygare, Johan; Lindström, M S; Bryder, David; Karlsson, Stefan

2015-01-01

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroid defect remain elusive. Previous studies have indicated that activation of p53 is caused by the inhibition of Mdm2, the main negative regulator of p53, by the 5S ribonucleoprot...

Achieving a More Sustainable Process Design for the Production of Methanol

DEFF Research Database (Denmark)

Plaza, Cristina Calvera; Gonzalez Garcia, Marta; Callau, Ana Diez

Methanol is an important chemical product because it can be used as a raw material for the production of other chemicals (1), for example dimethyl carbonate, formaldehyde and methyl tert-butyl ether and it is also one of the most produced bulk chemicals with an annual global production of 100...... million metric tonnes per year (1). Methanol can be produced using different reaction paths, for example natural gas. If natural gas is used for methanol production then CO2 is produced, utilized and can be emitted. Therefore, achieving a more sustainable design for the production of methanol...

The System of Indicators for Monitoring the Achievement of the Goals of Sustainable Development in the Agrarian Sector

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Chala Tеtyana G.

2017-06-01

Full Text Available The article describes the results of statistical evaluation of the system of indicators for monitoring the achievement of the goals of sustainable development (GSD in the agrarian sector. It has been determined that, in order to achieve sustainable development, the following three pillars need to be reconciled: economic growth, social integration, and environmental protection. The objectives and indicators of the GSD 2 «Overcoming hunger, achieving food security, improving nutrition, and facilitating sustainable development of agriculture» were considered in detail. It has been determined that the indicator, which illustrates vividly the status and perspective of development of the agrarian sector, is the indicator 2.a.1 «Index of orientation towards agriculture, defined by the public expenditure structure». Methods for calculation of the Agriculture Orientation Index (AOI were considered. The dynamics of the AOI for Ukraine and world-wide for 2004-2013 were analyzed. The values of the AOI index for Ukraine, the neighboring countries, and the EU Member States in 2013 have been provided. It has been determined that Ukraine has a low AOI among the EU countries and among the neighboring countries, which indicates a poor orientation towards agriculture.

Generation of erythroid cells from polyploid giant cancer cells: re-thinking about tumor blood supply.

Science.gov (United States)

Yang, Zhigang; Yao, Hong; Fei, Fei; Li, Yuwei; Qu, Jie; Li, Chunyuan; Zhang, Shiwu

2018-04-01

During development and tumor progression, cells need a sufficient blood supply to maintain development and rapid growth. It is reported that there are three patterns of blood supply for tumor growth: endothelium-dependent vessels, mosaic vessels, and vasculogenic mimicry (VM). VM was first reported in highly aggressive uveal melanomas, with tumor cells mimicking the presence and function of endothelial cells forming the walls of VM vessels. The walls of mosaic vessels are randomly lined with both endothelial cells and tumor cells. We previously proposed a three-stage process, beginning with VM, progressing to mosaic vessels, and eventually leading to endothelium-dependent vessels. However, many phenomena unique to VM channel formation remain to be elucidated, such as the origin of erythrocytes before VM vessels connect with endothelium-dependent vessels. In adults, erythroid cells are generally believed to be generated from hematopoietic stem cells in the bone marrow. In contrast, embryonic tissue obtains oxygen through formation of blood islands, which are largely composed of embryonic hemoglobin with a higher affinity with oxygen, in the absence of mature erythrocytes. Recent data from our laboratory suggest that embryonic blood-forming mechanisms also exist in cancer tissue, particularly when these tissues are under environmental stress such as hypoxia. We review the evidence from induced pluripotent stem cells in vitro and in vivo to support this previously underappreciated cell functionality in normal and cancer cells, including the ability to generate erythroid cells. We will also summarize the current understanding of tumor angiogenesis, VM, and our recent work on polyploid giant cancer cells, with emphasis on their ability to generate erythroid cells and their association with tumor growth under hypoxia. An alternative embryonic pathway to obtain oxygen in cancer cells exists, particularly when they are under hypoxic conditions.

Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.

Directory of Open Access Journals (Sweden)

Jian-Guo Ren

2010-09-01

Full Text Available Malic enzyme 2 (ME2 is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO2 and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. We found that ME2 is expressed in K562 erythroleukemia cells, in which a number of agents have been found to induce differentiation either along the erythroid or the myeloid lineage. We found that knockdown of ME2 led to diminished proliferation of tumor cells and increased apoptosis in vitro. These findings were accompanied by differentiation of K562 cells along the erythroid lineage, as confirmed by staining for glycophorin A and hemoglobin production. ME2 knockdown also totally abolished growth of K562 cells in nude mice. Increased ROS levels, likely reflecting increased mitochondrial production, and a decreased NADPH/NADP+ ratio were noted but use of a free radical scavenger to decrease inhibition of ROS levels did not reverse the differentiation or apoptotic phenotype, suggesting that ROS production is not causally involved in the resultant phenotype. As might be expected, depletion of ME2 induced an increase in the NAD+/NADH ratio and ATP levels fell significantly. Inhibition of the malate-aspartate shuttle was insufficient to induce K562 differentiation. We also examined several intracellular signaling pathways and expression of transcription factors and intermediate filament proteins whose expression is known to be modulated during erythroid differentiation in K562 cells. We found that silencing of ME2 leads to phospho-ERK1/2 inhibition, phospho-AKT activation, increased GATA-1 expression and diminished vimentin expression. Metabolomic analysis, conducted to gain insight into intermediary metabolic pathways that ME2 knockdown might affect, showed that ME2 depletion resulted in high orotate levels, suggesting potential impairment of pyrimidine metabolism. Collectively our data point to ME2 as a potentially novel

The Implementation of Knowledge Strategy-Based Entrepreneurial Capacity to Achieve Sustainable Competitive Advantage

OpenAIRE

Widodo

2013-01-01

This study aims to develop a model of knowledge strategy-based entrepreneurial capacity to achieve sustainable competitive advantage of rurol banking in Central Java province. The sampling method is ‘‘Purposive sampling’’ by considering the characteristics of the population items, namely: operational experience for at least 5 years and representatives of each area of rurol banking in Semarang, Surakarta and Purwokerto. Then, the sample size is 150 of 251 (59.7%) of top managers of rurol bank...

Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage

OpenAIRE

Zhang, Pan; Herbig, Utz; Coffman, Frederick; Lambert, Muriel W.

2013-01-01

Telomere integrity is critical for telomere function and genomic stability. We previously demonstrated that non-erythroid ?-spectrin (?IISp) is present in mammalian cell nuclei where it is important in repair of DNA interstrand cross-links (ICLs) and chromosome stability. We now demonstrate that ?IISp is also important for telomere maintenance after ICL damage. It localizes to telomeres in S phase after ICL damage where it has enhanced association with TRF1 and TRF2 and is required for recrui...

Expression of assayable residual stem cell damage in erythroid differentiation

International Nuclear Information System (INIS)

Huebner, G.E.; Miller, M.E.; Cronkite, E.P.

1985-01-01

In rodents, residual damage is inducible in hematopoietic stem cells by exposure to ionizing radiation or alkylating agents. This damage can b e assayed in mice by transferring bone marrow into lethally irradiated syngeneic recipients and subsequently measuring the incremental increase of-( 125 I)iodo-2'-deoxyuridine incorporation in spleens. In this study, bone marrow from mice treated 3 weeks previously with Methylnitrosourea (50 mg/kg) or 450 rad was injected into recipients in order to determine possible residual effects of treatment of erythroid cell differentiation following stem cell seeding. Such effects were detected by a reduced amount of 59 Fe incorporation into spleens, thus indicatin g transfer of residual stem cell damage to differentiating cells. (orig.)

Achieving the 1.5 °C Objective: Just Implementation Through a Right to (Sustainable) Development Approach

NARCIS (Netherlands)

J. Gupta (Joyeeta); C.J.M. Arts (Karin)

2017-01-01

textabstractAchieving the 1.5 C objective of the Paris Agreement on Climate Change in a just manner requires equitably sharing the responsibilities and rights that relate to this objective. This paper examines how international law concerning the Right to Promote (Sustainable) Development can

Addressing China's grand challenge of achieving food security while ensuring environmental sustainability.

Science.gov (United States)

Lu, Yonglong; Jenkins, Alan; Ferrier, Robert C; Bailey, Mark; Gordon, Iain J; Song, Shuai; Huang, Jikun; Jia, Shaofeng; Zhang, Fusuo; Liu, Xuejun; Feng, Zhaozhong; Zhang, Zhibin

2015-02-01

China's increasingly urbanized and wealthy population is driving a growing and changing demand for food, which might not be met without significant increase in agricultural productivity and sustainable use of natural resources. Given the past relationship between lack of access to affordable food and political instability, food security has to be given a high priority on national political agendas in the context of globalization. The drive for increased food production has had a significant impact on the environment, and the deterioration in ecosystem quality due to historic and current levels of pollution will potentially compromise the food production system in China. We discuss the grand challenges of not only producing more food but also producing it sustainably and without environmental degradation. In addressing these challenges, food production should be considered as part of an environmental system (soil, air, water, and biodiversity) and not independent from it. It is imperative that new ways of meeting the demand for food are developed while safeguarding the natural resources upon which food production is based. We present a holistic approach to both science and policy to ensure future food security while embracing the ambition of achieving environmental sustainability in China. It is a unique opportunity for China to be a role model as a new global player, especially for other emerging economies.

Characterization of human erythroid burst-promoting activity derived from bone marrow conditioned media

International Nuclear Information System (INIS)

Porter, P.N.; Ogawa, M.

1982-01-01

Bone marrow conditioned media (BMCM) increases burst number and the incorporation of 59 Fe into heme by bursts when peripheral blood or bone marrow cells are cultured at limiting serum concentrations. Burst-promoting activity (BPA) has now been purified approximately 300-fold from this source by ion-exchange chromatography on DEAE-Sephadex and absorption chromatography on hydroxyapatite agarose gel. Marrow BPA increased burst number and hemoglobin (Hb) synthesis in a dose-dependent manner. A larger increase in Hb synthesis than in burst number was consistently observed, which was probably a consequence of the increase in the number of cells per burst that occurs in the presence of BPA. The role of BPA in culture could be distinguished from erythropoietin (Ep), since no bursts grew in the absence of Ep, whether or not BPA was present, and since it had no effect on the growth of erythroid colonies scored at day 5 of culture. Our purified fraction did not support the growth of CFU-C in culture. Activity was stable at temperatures of 70 degrees C or lower for 10 min; exposure to 80 degrees C resulted in approximately 50% loss of activity. BPA was completely inactivated by treatment at 100 degrees C for 10 min. Thus, human bone marrow cells produce a heat-sensitive factor that specifically promotes the growth of early erythroid progenitors in culture

Corporate Governance as a Crucial Factor in Achieving Sustainable Corporate Performance

Directory of Open Access Journals (Sweden)

Julija Bistrova

2014-06-01

Full Text Available In the developed stock markets the corporate governance aspect is crucial in the stock portfolio selection process for investor seeking to achieve shareholder value sustainability. In the emerging markets the importance of the corporate governance role just starts to be realized by the investors and by the corporate managers. The present research, looking at the stock performance leaders and laggards, analyzes whether the corporate governance system matters to achieve long-term shareholder value within the Central and Eastern European stock markets universe. Corporate governance quality was assessed and compared among the out- and underperformers. The financial results plausibility and the ownership structure were considered as well. Additionally, the authors analyzed whether the quality of corporate governance influences the economic performance of the company. The obtained results provide the proof that the corporate governance does matter as the market outperformers have above average corporate governance quality and provide trustworthy financial results more often than the underperforming companies. Besides, well-governed companies are also able to deliver more attractive financial results.

Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies.

Science.gov (United States)

Vizirianakis, Ioannis S; Papachristou, Eleni T; Andreadis, Panagiotis; Zopounidou, Elena; Matragkou, Christina N; Tsiftsoglou, Asterios S

2015-07-01

Impairment of ribosome biogenesis contributes to the molecular pathophysiology of ribosomopathies by deregulating cell-lineage specific proliferation, differentiation and apoptosis decisions of haematopoietic progenitor cells. Here, using pro-erythroblast-like murine erythroleukemia (MEL) cells, a model system of erythroid maturation, we aimed to investigate whether genetic manipulation of RPS5 expression affects the capacity of cells to grow and differentiate in culture. Parental MEL cells stably transfected with full length RPS5 cDNA in sense (MEL-C14 culture) or antisense (MEL-antisenseRPS5 culture) orientation, as well as MEL cells transiently transfected with siRNAs specific for RPS5 gene silencing (MEL-RPS5siRNA culture) were assessed for their ability to fully execute their erythroid maturation program in culture. The data obtained thus far indicate that: a) MEL-antisenseRPS5 exhibit a pronounced delay in the initiation of differentiation, as well as an impairment of commitment, since the continuous presence of the inducer in culture is required for the cells to fully execute their erythroid maturation program. b) RNAi-mediating silencing of RPS5 gene expression resulted in the inability of MEL cells to differentiate; however, when these cells were allowed to recapitulate normal RPS5 gene expression levels they regained their differentiation capacity by accumulating high proportion of erythroid mature cells. c) Interestingly the latter, is accompanied by morphological changes of cells and an impairment of their proliferation and apoptosis potential. Such data for the first time correlate the RPS5 gene expression levels with the differentiation capacity of MEL cells in vitro, a fact that might also have implications in understanding ribosomopathies.

Achieving a Sustainable Urban Form through Land Use Optimisation: Insights from Bekasi City’s Land-Use Plan (2010–2030

Directory of Open Access Journals (Sweden)

Rahmadya Trias Handayanto

2017-02-01

Full Text Available Cities worldwide have been trying to achieve a sustainable urban form to handle their rapid urban growth. Many sustainable urban forms have been studied and two of them, the compact city and the eco city, were chosen in this study as urban form foundations. Based on these forms, four sustainable city criteria (compactness, compatibility, dependency, and suitability were considered as necessary functions for land use optimisation. This study presents a land use optimisation as a method for achieving a sustainable urban form. Three optimisation methods (particle swarm optimisation, genetic algorithms, and a local search method were combined into a single hybrid optimisation method for land use in Bekasi city, Indonesia. It was also used for examining Bekasi city’s land-use-plan (2010–2030 after optimising current (2015 and future land use (2030. After current land use optimisation, the score of sustainable city criteria increased significantly. Three important centres of land use (commercial, industrial, and residential were also created through clustering the results. These centres were slightly different from centres of the city plan zones. Additional land uses in 2030 were predicted using a nonlinear autoregressive neural network with external input. Three scenarios were used for allocating these additional land uses including sustainable development, government policy, and business-as-usual. Future land use allocation in 2030 found that the sustainable development scenario showed better performance compared to government policy and business-as-usual scenarios.

The importance of an integrating framework for achieving the Sustainable Development Goals: the example of health and well-being.

Science.gov (United States)

Nunes, Ana Raquel; Lee, Kelley; O'Riordan, Tim

2016-01-01

The 2030 Agenda for Sustainable Development came into force in January 2016 as the central United Nations (UN) platform for achieving 'integrated and indivisible' goals and targets across the three characteristic dimensions of sustainable development: the social, environmental and economic. We argue that, despite the UN adoption of the Sustainable Development Goals (SDGs), a framework for operationalising them in an integrated fashion is lacking. This article puts forth a framework for integrating health and well-being across the SDGs as both preconditions and outcomes of sustainable development. We present a rationale for this approach, and identify the challenges and opportunities for implementing and monitoring such a framework through a series of examples. We encourage other sectors to develop similar integrating frameworks for supporting a more coordinated approach for operationalising the 2030 Agenda for Sustainable Development.

Future-Proofed Energy Design Approaches for Achieving Low-Energy Homes: Enhancing the Code for Sustainable Homes

Directory of Open Access Journals (Sweden)

Maria Christina Georgiadou

2014-09-01

Full Text Available Under the label “future-proofing”, this paper examines the temporal component of sustainable construction as an unexplored, yet fundamental ingredient in the delivery of low-energy domestic buildings. The overarching aim is to explore the integration of future-proofed design approaches into current mainstream construction practice in the UK, focusing on the example of the Code for Sustainable Homes (CSH tool. Regulation has been the most significant driver for achieving the 2016 zero-carbon target; however, there is a gap between the appeal for future-proofing and the lack of effective implementation by building professionals. Even though the CSH was introduced as the leading tool to drive the “step-change” required for achieving zero-carbon new homes by 2016 and the single national standard to encourage energy performance beyond current statutory minima, it lacks assessment criteria that explicitly promote a futures perspective. Based on an established conceptual model of future-proofing, 14 interviews with building practitioners in the UK were conducted to identify the “feasible” and “reasonably feasible” future-proofed design approaches with the potential to enhance the “Energy and CO2 Emissions” category of the CSH. The findings are categorised under three key aspects; namely: coverage of sustainability issues; adopting lifecycle thinking; and accommodating risks and uncertainties and seek to inform industry practice and policy-making in relation to building energy performance.

Proteomic analysis of erythroid differentiation induced by hexamethylene bisacetamide in murine erythroleukemia cells

Czech Academy of Sciences Publication Activity Database

Petrák, J.; Myslivcová, D.; Man, Petr; Čmejlová, J.; Čmejla, R.; Vyoral, D.

2007-01-01

Roč. 35, - (2007), s. 193-202 ISSN 0301-472X R&D Projects: GA MŠk LC545 Grant - others:CZ(CZ) 023736; GA ČR(CZ) GA303/04/0003; GA MŠk(CZ) LC06044 Institutional research plan: CEZ:AV0Z50200510 Source of funding: V - iné verejné zdroje ; V - iné verejné zdroje ; V - iné verejné zdroje Keywords : murine erythroleukemia cells * erythroid differentiation * hexamethylene bisacetamide Subject RIV: EE - Microbiology, Virology Impact factor: 3.147, year: 2007

The history of wealth concept and ways to achieve it for sustainable development

Directory of Open Access Journals (Sweden)

O. A. Kalchenko

2016-01-01

Full Text Available The evolution of well-known philosophers and economists views on wealth is considered: Voltaire, Adam Smith, JeanJacques Rousseau, Karl Marx, John Stuart Mill, Milton Friedman, John Maynard Keynes, Joseph Schumpeter, Georg von Wallwitz and others. Economics was initially studying ways and means of achieving wealth. The essence of wealth has changed dramatically in people's minds after the first and the second industrial revolutions. The world today is on the verge of the third industrial revolution (according to Jeremy Rifkin, or, as it is called by many scientists, the new tenor of technology. In the history of any civilization comes the moment of a radical direction change for new prospects or endangered. Not all civilizations were able to transform in time. However, in the past, the effects of civilizations collapse were limited in time, space, and never addressed the species. Currently, the high probability of temperature and planet geochemistry changes as a result of climate change can lead to mass extinction of animals, plants, and people. Humanity has the ability to transit into a stable post-carbon era in the middle of the century and to prevent catastrophic climate change. Currently, sustainable development is the mechanism used to achieve the ultimate goal of any country, enterprise and human development, which is wealth. Under controlled sustainable development we understand the system unity of not only economic, social, environmental, but also resource, technological, institutional activities, as well as a permanent interaction between development and economic safety.

Sustainability and Organizational Change by Sustainable Crediting Therapy

Directory of Open Access Journals (Sweden)

Dragoş Ilie

2012-06-01

Full Text Available The objective of this paper is to demonstrate that one of the therapies to achieve sustainability and organizational change in the context of current challenges in the national economies is sustainable crediting. The research method is based on a survey of 30 commercial companies from various fields of activity that have or have not implemented, at the leadership level, the concept of sustainable crediting. The data collecting and processing approach has resulted in the determination of the main economic-financial indicators for a period of 5 years, indicators used by banks in relation with the credited organizations. The main results show that companies that have implemented the sustainable crediting concept are more able to achieve sustainability in their developed activity, as well as organizational change with positive effects on their business and on the company as a whole. The concept of sustainable crediting implies the capitalization of the commercial companies, the increase of the loan portfolio quality, the achievement of the financial balance and environmental protection

The Role of Deliberative Collaborative Governance in Achieving Sustainable Cities

Directory of Open Access Journals (Sweden)

Margaret Gollagher

2013-05-01

Full Text Available Sustainability issues involve complex interactions between social, economic, and environmental factors that are often viewed quite differently by disparate stakeholder groups. Issues of non-sustainability are wicked problems that have many, often obscure causes, and for which there is no single, straightforward solution. Furthermore, the concept of sustainability is itself contested. For example there are disputes over whether a strong or weak interpretation of sustainability should be adopted. In cities, as elsewhere, sustainability therefore requires discursive plurality and multiple sites of action. It is the thesis of this paper that effective problem solving, decision-making and enacting of a sustainability agenda require deliberative collaborative governance (DCG, a logical hybrid of the closely related fields of deliberative democracy and collaborative governance. We provide a provisional typology of different modes of deliberative collaborative governance, explaining each with a sustainability example, with a particular focus on DCG initiatives for planning in Western Australia. It is argued that the lens provided by such a typology can help us to understand the factors likely to promote better resolution of wicked problems and increased sustainability.

Securing Communal Land Rights to Achieve Sustainable Development in Sub-Saharan Africa: Critical Analysis and Policy Implications

Directory of Open Access Journals (Sweden)

Ross Andrew Clarke

2009-09-01

Full Text Available While the concept of sustainable development gains increasing traction under international law, effective and scalable policies to translate these principles into practice remain largely beyond reach. This article analyses one possible strategy in Sub-Saharan Africa - increasing security of communal tenure to improve resource management and achieve rural sustainable development. Although this approach has attracted some attention, particularly with management responsibility of communal property increasingly devolved to the community-level, the expected results in terms of more sustainable resource exploitation and sounder environmental management have yet to be realised. Through critical analysis, with particular emphasis on the Gestion Terroir approach in Burkina Faso , the article explores the reasons behind the limited success. The article suggests that greater emphasis must be placed on bridging statutory command-and-control regimes with community-based models. Focusing on the links between communal land tenure and environmental management, and effectively embedding community land management institutions within existing environmental governance structures offers a practical model to promote sustainable development.

Achieving sustainable plant disease management through evolutionary principles.

Science.gov (United States)

Zhan, Jiasui; Thrall, Peter H; Burdon, Jeremy J

2014-09-01

Plants and their pathogens are engaged in continuous evolutionary battles and sustainable disease management requires novel systems to create environments conducive for short-term and long-term disease control. In this opinion article, we argue that knowledge of the fundamental factors that drive host-pathogen coevolution in wild systems can provide new insights into disease development in agriculture. Such evolutionary principles can be used to guide the formulation of sustainable disease management strategies which can minimize disease epidemics while simultaneously reducing pressure on pathogens to evolve increased infectivity and aggressiveness. To ensure agricultural sustainability, disease management programs that reflect the dynamism of pathogen population structure are essential and evolutionary biologists should play an increasing role in their design. Copyright © 2014 Elsevier Ltd. All rights reserved.

Achieving and Sustaining Universal Health Coverage: Fiscal Reform of the National Health Insurance in Taiwan.

Science.gov (United States)

Lan, Jesse Yu-Chen

2017-12-01

The paper discusses the expansion of the universal health coverage (UHC) in Taiwan through the establishment of National Health Insurance (NHI), and the fiscal crisis it caused. Two key questions are addressed: How did the NHI gradually achieve universal coverage, and yet cause Taiwanese health spending to escalate to fiscal crisis? What measures have been taken to reform the NHI finance and achieve moderate success to date? The main argument of this paper is that the Taiwanese Government did try to implement various reforms to save costs and had moderate success, but the path-dependent process of reform does not allow increasing contribution rates significantly and thereby makes sustainability challenging.

The importance of an integrating framework for achieving the Sustainable Development Goals: the example of health and well-being

Science.gov (United States)

Lee, Kelley; O'Riordan, Tim

2016-01-01

The 2030 Agenda for Sustainable Development came into force in January 2016 as the central United Nations (UN) platform for achieving ‘integrated and indivisible’ goals and targets across the three characteristic dimensions of sustainable development: the social, environmental and economic. We argue that, despite the UN adoption of the Sustainable Development Goals (SDGs), a framework for operationalising them in an integrated fashion is lacking. This article puts forth a framework for integrating health and well-being across the SDGs as both preconditions and outcomes of sustainable development. We present a rationale for this approach, and identify the challenges and opportunities for implementing and monitoring such a framework through a series of examples. We encourage other sectors to develop similar integrating frameworks for supporting a more coordinated approach for operationalising the 2030 Agenda for Sustainable Development. PMID:28588955

Factors associated with sustainability of 2 quality improvement programs after achieving early implementation success. A qualitative case study.

Science.gov (United States)

Ament, Stephanie M C; Gillissen, Freek; Moser, Albine; Maessen, José M C; Dirksen, Carmen D; von Meyenfeldt, Maarten F; van der Weijden, Trudy

2017-12-01

Sustainability of innovations is a relatively new concept in health care research and has become an issue of growing interest. The current study explored factors related to the sustainability of 2 multidisciplinary hospital-based programs 3 to 6 years after achieving early implementation success. An exploratory qualitative study was conducted into 2 implementation cases, an Enhanced Recovery After Surgery program for colorectal surgery and a short-stay program for breast cancer surgery. Semistructured interviews were held with key persons involved in the care process in 14 hospitals from both cases minimally 3 years after the implementation, between March 2012 and May 2013. The Consolidated Framework for Implementation Research was used to direct the development of the interview guide, during data collection and during analysis. A directed content analysis was performed. A total of 21 interviews with 26 individuals were held, 18 regarding the Enhanced Recovery After Surgery case and 8 regarding the short-stay program case. Respondents mentioned the following factors associated with sustainability of the programs: modification and adaptability of the program, cost-effectiveness, institutionalization into existing systems, short communication lines within the multidisciplinary team, an innovative culture, benefits for patients, cosmopolitanism, the existence of external policies and incentives, trust and belief in the program, and spread of the program to other settings. Two factors are not covered by the Consolidated Framework for Implementation Research, ie, modification of the program over the years and spread of the program to other contexts. The factors associated with sustainability put forward in both cases were largely the same. Leadership and the implementation project were not mentioned as having influenced the long-term sustainability of the benefits achieved. Sustainability of the innovations is influenced by determinants stemming from all ecological

Using a framework to implement large-scale innovation in medical education with the intent of achieving sustainability.

Science.gov (United States)

Hudson, Judith N; Farmer, Elizabeth A; Weston, Kathryn M; Bushnell, John A

2015-01-16

Particularly when undertaken on a large scale, implementing innovation in higher education poses many challenges. Sustaining the innovation requires early adoption of a coherent implementation strategy. Using an example from clinical education, this article describes a process used to implement a large-scale innovation with the intent of achieving sustainability. Desire to improve the effectiveness of undergraduate medical education has led to growing support for a longitudinal integrated clerkship (LIC) model. This involves a move away from the traditional clerkship of 'block rotations' with frequent changes in disciplines, to a focus upon clerkships with longer duration and opportunity for students to build sustained relationships with supervisors, mentors, colleagues and patients. A growing number of medical schools have adopted the LIC model for a small percentage of their students. At a time when increasing medical school numbers and class sizes are leading to competition for clinical supervisors it is however a daunting challenge to provide a longitudinal clerkship for an entire medical school class. This challenge is presented to illustrate the strategy used to implement sustainable large scale innovation. A strategy to implement and build a sustainable longitudinal integrated community-based clerkship experience for all students was derived from a framework arising from Roberto and Levesque's research in business. The framework's four core processes: chartering, learning, mobilising and realigning, provided guidance in preparing and rolling out the 'whole of class' innovation. Roberto and Levesque's framework proved useful for identifying the foundations of the implementation strategy, with special emphasis on the relationship building required to implement such an ambitious initiative. Although this was innovation in a new School it required change within the school, wider university and health community. Challenges encountered included some resistance to

PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors

Directory of Open Access Journals (Sweden)

Schmidt Enrico K

2004-05-01

Full Text Available Abstract Background Erythropoietin is a multifunctional cytokine which regulates the number of erythrocytes circulating in mammalian blood. This is crucial in order to maintain an appropriate oxygen supply throughout the body. Stimulation of primary human erythroid progenitors (PEPs with erythropoietin (Epo leads to the activation of the mitogenic kinases (MEKs and Erks. How this is accomplished mechanistically remained unclear. Results Biochemical studies with human cord blood-derived PEPs now show that Ras and the class Ib enzyme of the phosphatidylinositol-3 kinase (PI3K family, PI3K gamma, are activated in response to minimal Epo concentrations. Surprisingly, three structurally different PI3K inhibitors block Ras, MEK and Erk activation in PEPs by Epo. Furthermore, Erk activation in PEPs is insensitive to the inhibition of Raf kinases but suppressed upon PKC inhibition. In contrast, Erk activation induced by stem cell factor, which activates c-Kit in the same cells, is sensitive to Raf inhibition and insensitive to PI3K and PKC inhibitors. Conclusions These unexpected findings contrast with previous results in human primary cells using Epo at supraphysiological concentrations and open new doors to eventually understanding how low Epo concentrations mediate the moderate proliferation of erythroid progenitors under homeostatic blood oxygen levels. They indicate that the basal activation of MEKs and Erks in PEPs by minimal concentrations of Epo does not occur through the classical cascade Shc/Grb2/Sos/Ras/Raf/MEK/Erk. Instead, MEKs and Erks are signal mediators of PI3K, probably the recently described PI3K gamma, through a Raf-independent signaling pathway which requires PKC activity. It is likely that higher concentrations of Epo that are induced by hypoxia, for example, following blood loss, lead to additional mitogenic signals which greatly accelerate erythroid progenitor proliferation.

Lean Transformation Guidance: Why Organizations Fail To Achieve and Sustain Excellence Through Lean Improvement

OpenAIRE

Mohammed Hamed Ahmed

2013-01-01

Many companies are complaining that lean didn’t achieve their long-term goals, and the improvement impact was very short-lived. 7 out of each 10 lean projects fail as companies try to use lean like a toolkit, copying and pasting the techniques without trying to adapt the employee’s culture, manage the improvement process, sustain the results, and develop their leaders. When the Toyota production system was created, the main goal was to remove wastes from the shop floor us...

Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.

Science.gov (United States)

Hamdi, Amel; Roshan, Tariq M; Kahawita, Tanya M; Mason, Anne B; Sheftel, Alex D; Ponka, Prem

2016-12-01

In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe 2+ into protoporphyrin IX. However, the path of iron from endosomes to mitochondrial ferrochelatase remains elusive. The prevailing opinion is that, after its export from endosomes, the redox-active metal spreads into the cytosol and mysteriously finds its way into mitochondria through passive diffusion. In contrast, this study supports the hypothesis that the highly efficient transport of iron toward ferrochelatase in erythroid cells requires a direct interaction between transferrin-endosomes and mitochondria (the "kiss-and-run" hypothesis). Using a novel method (flow sub-cytometry), we analyze lysates of reticulocytes after labeling these organelles with different fluorophores. We have identified a double-labeled population definitively representing endosomes interacting with mitochondria, as demonstrated by confocal microscopy. Moreover, we conclude that this endosome-mitochondrion association is reversible, since a "chase" with unlabeled holotransferrin causes a time-dependent decrease in the size of the double-labeled population. Importantly, the dissociation of endosomes from mitochondria does not occur in the absence of holotransferrin. Additionally, mutated recombinant holotransferrin, that cannot release iron, significantly decreases the uptake of 59 Fe by reticulocytes and diminishes 59 Fe incorporation into heme. This suggests that endosomes, which are unable to provide iron to mitochondria, cause a "traffic jam" leading to decreased endocytosis of holotransferrin. Altogether, our results suggest that a molecular mechanism exists to coordinate the iron status of endosomal transferrin with its trafficking. Besides its contribution to the field of iron metabolism, this study provides evidence for a new intracellular trafficking pathway of organelles. Copyright © 2016 Elsevier B.V. All rights reserved.

Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle

International Nuclear Information System (INIS)

Finaurini, Sara; Basilico, Nicoletta; Corbett, Yolanda; D’Alessandro, Sarah; Parapini, Silvia; Olliaro, Piero; Haynes, Richard K.; Taramelli, Donatella

2012-01-01

Artemisinin derivatives such as dihydroartemisinin (DHA) induce significant depletion of early embryonic erythroblasts in animal models. We have reported previously that DHA specifically targets pro-erythroblasts and basophilic erythroblasts, when human CD34+ stem cells are differentiated toward the erythroid lineage, indicating that a window of susceptibility to artemisinins may exist also in human developmental erythropoiesis during pregnancy. To better investigate the toxicity of artemisinin derivatives, the structure–activity relationship was evaluated against the K562 leukaemia cell line, used as a model for differentiating early human erythroblasts. All artemisinins derivatives, except deoxyartemisinin, inhibited both spontaneous and induced erythroid differentiation, confirming that the peroxide bridge is responsible for the erythro-toxicity. On the contrary, cell growth was markedly reduced by DHA, artemisone and artesunate but not by artemisinin, 10-deoxoartemisinin or deoxy-artemisinin. The substituent at position C-10 is responsible only for the anti-proliferative effect, since 10-deoxoartemisinin did not reduce cell growth but arrested the differentiation of K562 cells. In particular, the results showed that DHA resulted the most potent and rapidly acting compound of the drug family, causing (i) the decreased expression of GpA surface receptors and the down regulation the γ-globin gene; (ii) the alteration of S phase of cell cycle and (iii) the induction of programmed cell death of early erythroblasts in a dose dependent manner within 24 h. In conclusion, these findings confirm that the active metabolite DHA is responsible for the erythro-toxicity of most of artemisinins used in therapy. Thus, as long as no further clinical data are available, current WHO recommendations of avoiding malaria treatment with artemisinins during the first trimester of pregnancy remain valid.

Distributed renewable energies for off-grid communities strategies and technologies toward achieving sustainability in energy generation and supply

CERN Document Server

El Bassam, Nasir; Schlichting, Marcia

2012-01-01

Energy is directly related to the most critical economic and social issues which affect sustainable development such as mobility, food production, environmental quality, regional and global security issues. Two-thirds of the new demand will come from developing nations, with China accounting for 30%. Without adequate attention to the critical importance of energy to all these aspects, the global, social, economic and environmental goals of sustainability cannot be achieved. Indeed the magnitude of change needed is immense, fundamental and directly related to the energy produced and consumed na

PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia

DEFF Research Database (Denmark)

Vannucchi, Alessandro M; Pancrazzi, Alessandro; Antonioli, Elisabetta

2004-01-01

markers of ET, namely PRV-1 overexpression, endogenous erythroid colony (EEC) formation, and reduced platelet Mpl content. Fifty-three (60%) of 88 subjects studied had monoclonal myelopoiesis and presented a 32% incidence of major thrombosis compared with 6% of polyclonal subjects (P = 0.......009). The frequency of abnormalities of PRV-1, EEC, or Mpl was similar in monoclonal and polyclonal subjects (respectively, 28%, 48%, 75%, and 37%, 27%, 63%), and none of them correlated with thrombosis. We conclude that the exploited epigenetic markers constitute independent phenotypic variations...

Innovative approach for achieving of sustainable urban water supply system by using of solar photovoltaic energy

Directory of Open Access Journals (Sweden)

Jure Margeta

2017-01-01

Full Text Available Paper describes and analyses new and innovative concept for possible integration of solar photovoltaic (PV energy in urban water supply system (UWSS. Proposed system consists of PV generator and invertor, pump station and water reservoir. System is sized in such a manner that every his part is sized separately and after this integrated into a whole. This integration is desirable for several reasons, where the most important is the achievement of the objectives of sustainable living in urban areas i.e. achieving of sustainable urban water supply system. The biggest technological challenge associated with the use of solar, wind and other intermittent renewable energy sources RES is the realization of economically and environmentally friendly electric energy storage (EES. The paper elaborates the use of water reservoires in UWSS as EES. The proposed solution is still more expensive than the traditional and is economically acceptable today in the cases of isolated urban water system and special situations. Wider application will depend on the future trends of energy prices, construction costs of PV generators and needs for CO2 reduction by urban water infrastructure.

Antisense myb inhibition of purified erythroid progenitors in development and differentiation is linked to cycling activity and expression of DNA polymerase alpha

International Nuclear Information System (INIS)

Valtieri, M.; Venturelli, D.; Care, A.; Fossati, C.; Pelosi, E.; Labbaye, C.; Mattia, G.; Gewirtz, A.M.; Calabretta, B.; Peschle, C.

1991-01-01

These studies aimed to determine the expression and functional role of c-myb in erythroid progenitors with different cycling activities. In the first series of experiments the erythroid burst-forming unit (BFU-E) and colony-forming unit (CFU-E) populations from adult peripheral blood (PB), bone marrow (BM), and embryonic-fetal liver (FL) were treated with either c-myb antisense oligomers or 3H-thymidine (3H-TdR). A direct correlation was always observed between the inhibitory effect of anti-myb oligomers and the level of cycling activity. Thus, the inhibitory effect of antisense c-myb on the number of BFU-E colonies was 28.3% +/- 15.8% in PB, 53.4% +/- 9.3% in BM, and 68.2% +/- 24.5% in FL. Both adult and embryonic CFU-E were markedly inhibited. Using purified PB progenitors, we observed a similar pattern, although with slightly lower inhibitory effects. In the 3H-TdR suicide assay the killing index of BFU-E was 8.9% +/- 4.2% in PB, 29.4% +/- 6.5% in BM, and 40.1% +/- 9.6% in FL. The values for adult and embryonic CFU-E were 55.7% +/- 7.9% and 60.98% +/- 6.6%, respectively. We then investigated the kinetics of c-myb mRNA level during the erythroid differentiation of purified adult PB and FL BFU-E, as evaluated in liquid-phase culture by reverse transcription-polymerase chain reaction. Adult erythroid precursors showed a gradual increase of c-myb mRNA from day 4 through day 8 of culture and a sharp decrease at later times, whereas the expression of c-myb mRNA and protein in differentiation embryonic precursors peaked 2 days earlier. In both cases, c-myb mRNA level peaked at the CFU-E stage of differentiation. Finally, highly purified adult PB BFU-E were stimulated into cycling by a 3-day treatment with interleukin-3 in liquid phase: both the sensitivity to c-myb antisense oligomers and the 3H-TdR suicide index showed a gradual, strictly parallel increase

Let-7 microRNAs are developmentally regulated in circulating human erythroid cells

Directory of Open Access Journals (Sweden)

Reed Christopher

2009-11-01

Full Text Available Abstract Background MicroRNAs are ~22nt-long small non-coding RNAs that negatively regulate protein expression through mRNA degradation or translational repression in eukaryotic cells. Based upon their importance in regulating development and terminal differentiation in model systems, erythrocyte microRNA profiles were examined at birth and in adults to determine if changes in their abundance coincide with the developmental phenomenon of hemoglobin switching. Methods Expression profiling of microRNA was performed using total RNA from four adult peripheral blood samples compared to four cord blood samples after depletion of plasma, platelets, and nucleated cells. Labeled RNAs were hybridized to custom spotted arrays containing 474 human microRNA species (miRBase release 9.1. Total RNA from Epstein-Barr virus (EBV-transformed lymphoblastoid cell lines provided a hybridization reference for all samples to generate microRNA abundance profile for each sample. Results Among 206 detected miRNAs, 79% of the microRNAs were present at equivalent levels in both cord and adult cells. By comparison, 37 microRNAs were up-regulated and 4 microRNAs were down-regulated in adult erythroid cells (fold change > 2; p let-7 miRNA family consistently demonstrated increased abundance in the adult samples by array-based analyses that were confirmed by quantitative PCR (4.5 to 18.4 fold increases in 6 of 8 let-7 miRNA. Profiling studies of messenger RNA (mRNA in these cells additionally demonstrated down-regulation of ten let-7 target genes in the adult cells. Conclusion These data suggest that a consistent pattern of up-regulation among let-7 miRNA in circulating erythroid cells occurs in association with hemoglobin switching during the fetal-to-adult developmental transition in humans.

Textiles and clothing sustainability sustainable technologies

CERN Document Server

2017-01-01

This is the first book to deal with the innovative technologies in the field of textiles and clothing sustainability. It details a number of sustainable and innovative technologies and highlights their implications in the clothing sector. There are currently various measures to achieve sustainability in the textiles and the clothing industry, including innovations in the manufacturing stage, which is the crux of this book.

The sustainable company: new challenges and strategies for more sustainability

Directory of Open Access Journals (Sweden)

Victor DANCIU

2013-09-01

Full Text Available The sustainability becomes a model of development only if countries, industries, businesses and citizens become sustainable. The contribution of the business to a promising future should come from a fully integrated sustainability in its DNA and strategies.This paper focuses on the needed sustainable strategies for scaling up the contribution of the companies to sustainable development in the future. At the beginning, we analyze the main theoretical points of view on sustainability. Then, we explain how companies could achieve the sustainability by following the steps of a difficult process and the present performances in sustainability of large companies around the world. Finally, we suggest four strategies that businesses could design and implement in order to scaling up their sustainability in the future.The research has two important conclusions on sustainability in business. One is that the sustainability pays off if it is integrated in the DNA of the companies. The other conclusion says that the companies will succeed to make the needed transformation for achieving a better sustainability in the future only if they design and perform strategies focused on improving sustainability.

Cultural development and environment: a necessity to achieve sustainable development

International Nuclear Information System (INIS)

Azhari, A.

2003-01-01

This paper stresses on the important role of cultural development and protection of environment as the main pillars of sustainable development. one of the article's goals to make link among culture, protection of environment and sustainable development. according to the article, part of our commitment to sustainable development is to keep balance among different dimensions of development (cultural/ economic/ political/ social) considering environmental ethics

Towards Intelligently - Sustainable Cities?

Directory of Open Access Journals (Sweden)

Luca Salvati

2013-04-01

Full Text Available In the quest for achieving sustainable cities, Intelligent and Knowledge City Programmes (ICPs and KCPs represent cost-efficient strategies for improving the overall performance of urban systems. However, even though nobody argues on the desirability of making cities “smarter”, the fundamental questions of how and to what extent can ICPs and KCPs contribute to the achievement of urban sustainability lack a precise answer. In the attempt of providing a structured answer to these interrogatives, this paper presents a methodology developed for investigating the modalities through which ICPs and KCPs contribute to the achievement or urban sustainability. Results suggest that ICPs and KCPs efficacy lies in supporting cities achieve a sustainable urban metabolism through optimization, innovation and behavior changes.

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells.

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Ruth Merkle

2016-08-01

Full Text Available Lung cancer, with its most prevalent form non-small-cell lung carcinoma (NSCLC, is one of the leading causes of cancer-related deaths worldwide, and is commonly treated with chemotherapeutic drugs such as cisplatin. Lung cancer patients frequently suffer from chemotherapy-induced anemia, which can be treated with erythropoietin (EPO. However, studies have indicated that EPO not only promotes erythropoiesis in hematopoietic cells, but may also enhance survival of NSCLC cells. Here, we verified that the NSCLC cell line H838 expresses functional erythropoietin receptors (EPOR and that treatment with EPO reduces cisplatin-induced apoptosis. To pinpoint differences in EPO-induced survival signaling in erythroid progenitor cells (CFU-E, colony forming unit-erythroid and H838 cells, we combined mathematical modeling with a method for feature selection, the L1 regularization. Utilizing an example model and simulated data, we demonstrated that this approach enables the accurate identification and quantification of cell type-specific parameters. We applied our strategy to quantitative time-resolved data of EPO-induced JAK/STAT signaling generated by quantitative immunoblotting, mass spectrometry and quantitative real-time PCR (qRT-PCR in CFU-E and H838 cells as well as H838 cells overexpressing human EPOR (H838-HA-hEPOR. The established parsimonious mathematical model was able to simultaneously describe the data sets of CFU-E, H838 and H838-HA-hEPOR cells. Seven cell type-specific parameters were identified that included for example parameters for nuclear translocation of STAT5 and target gene induction. Cell type-specific differences in target gene induction were experimentally validated by qRT-PCR experiments. The systematic identification of pathway differences and sensitivities of EPOR signaling in CFU-E and H838 cells revealed potential targets for intervention to selectively inhibit EPO-induced signaling in the tumor cells but leave the responses in

Parvovirus B19 Replication and Expression in Differentiating Erythroid Progenitor Cells.

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Gloria Bua

Full Text Available The pathogenic Parvovirus B19 (B19V is characterized by a strict adaptation to erythroid progenitor cells (EPCs, a heterogeneous population of differentiating cells with diverse phenotypic and functional properties. In our work, we studied the dynamics of B19V infection in EPCs in dependence on the cell differentiation stage, in terms of distribution of infected cells, synthesis of viral nucleic acids and production of infectious virus. EPCs at early differentiation stage led to an abortive infection, without viral genome replication and a very low transcriptional activity. EPCs at later stages were permissive, with highest levels of viral replicative activity at day 9 (+3.0 Log from 2 to 48 hpi and lower levels at day 18 (+1.5 Log from 2 to 48 hpi. B19V DNA increment was in accordance with the percentage of cells positive to flow-FISH assay (41.4% at day 9, 1.1% at day 18. Quantitation of total RNA indicated a close association of genome replication and transcription with viral RNA accumulation within infected cells related to viral DNA increase during the course of infection. Analysis of the different classes of mRNAs revealed two distinct pattern of genome expression profile with a fine regulation in the frequency utilization of RNA processing signals: an early phase, when cleavage at the proximal site leading to a higher relative production of mRNA for NS protein, and a late phase, when cleavage at the distal site was more frequent leading to higher relative abundance of mRNA for VP and 11 kDA proteins. Infectious virus was released from cells at day 6-15, but not at day 18. Our results, providing a detailed description of B19V replication and expression profile in differentiating EPCs, highlight the very tight adaptation of B19V to a specific cellular target defined both by its erythroid lineage and its differentiation stage.

Parvovirus B19 Replication and Expression in Differentiating Erythroid Progenitor Cells

Science.gov (United States)

Bua, Gloria; Manaresi, Elisabetta; Bonvicini, Francesca; Gallinella, Giorgio

2016-01-01

The pathogenic Parvovirus B19 (B19V) is characterized by a strict adaptation to erythroid progenitor cells (EPCs), a heterogeneous population of differentiating cells with diverse phenotypic and functional properties. In our work, we studied the dynamics of B19V infection in EPCs in dependence on the cell differentiation stage, in terms of distribution of infected cells, synthesis of viral nucleic acids and production of infectious virus. EPCs at early differentiation stage led to an abortive infection, without viral genome replication and a very low transcriptional activity. EPCs at later stages were permissive, with highest levels of viral replicative activity at day 9 (+3.0 Log from 2 to 48 hpi) and lower levels at day 18 (+1.5 Log from 2 to 48 hpi). B19V DNA increment was in accordance with the percentage of cells positive to flow-FISH assay (41.4% at day 9, 1.1% at day 18). Quantitation of total RNA indicated a close association of genome replication and transcription with viral RNA accumulation within infected cells related to viral DNA increase during the course of infection. Analysis of the different classes of mRNAs revealed two distinct pattern of genome expression profile with a fine regulation in the frequency utilization of RNA processing signals: an early phase, when cleavage at the proximal site leading to a higher relative production of mRNA for NS protein, and a late phase, when cleavage at the distal site was more frequent leading to higher relative abundance of mRNA for VP and 11 kDA proteins. Infectious virus was released from cells at day 6–15, but not at day 18. Our results, providing a detailed description of B19V replication and expression profile in differentiating EPCs, highlight the very tight adaptation of B19V to a specific cellular target defined both by its erythroid lineage and its differentiation stage. PMID:26845771

Sustainable Pest Management : Achievements and Challenges

OpenAIRE

World Bank

2005-01-01

The objective of this paper is to: (a) review World Bank's pest management activities during 1999-2004; (b) assess those in view of the changes in the external and internal contexts; (c) identify appropriate opportunities of engagement on pest and pesticide issues; and (d) suggest means to further promote sound pest management in the World Bank operations. The importance of sound pest management for sustainable agricultural production is being recognized by many developing countries. Many cou...

Erythroid Kruppel-like factor (EKLF) is recruited to the γ-globin gene promoter as a co-activator and is required for γ-globin gene induction by short-chain fatty acid derivatives

Science.gov (United States)

Perrine, Susan P.; Mankidy, Rishikesh; Boosalis, Michael S.; Bieker, James J.; Faller, Douglas V.

2011-01-01

Objectives The erythroid Kruppel-like factor (EKLF) is an essential transcription factor for β-type globin gene switching, and specifically activates transcription of the adult β-globin gene promoter. We sought to determine if EKLF is also required for activation of the γ-globin gene by short-chain fatty acid (SCFA) derivatives, which are now entering clinical trials. Methods The functional and physical interaction of EKLF and co-regulatory molecules with the endogenous human globin gene promoters was studied in primary human erythroid progenitors and cell lines, using chromatin immunoprecipitation (ChIP) assays and genetic manipulation of the levels of EKLF and co-regulators. Results and conclusions Knockdown of EKLF prevents SCFA-induced expression of the γ-globin promoter in a stably expressed μLCRβprRlucAγprFluc cassette, and prevents induction of the endogenous γ-globin gene in primary human erythroid progenitors. EKLF is actively recruited to endogenous γ-globin gene promoters after exposure of primary human erythroid progenitors, and murine hematopoietic cell lines, to SCFA derivatives. The core ATPase BRG1 subunit of the human SWI/WNF complex, a ubiquitous multimeric complex that regulates gene expression by remodeling nucleosomal structure, is also required for γ-globin gene induction by SCFA derivatives. BRG1 is actively recruited to the endogenous γ-globin promoter of primary human erythroid progenitors by exposure to SCFA derivatives, and this recruitment is dependent upon the presence of EKLF. These findings demonstrate that EKLF, and the co-activator BRG1, previously demonstrated to be required for definitive or adult erythropoietic patterns of globin gene expression, are co-opted by SCFA derivatives to activate the fetal globin genes. PMID:19220418

Beyond good intentions: the role of proactive coping in achieving sustained behavioural change in the context of diabetes management.

NARCIS (Netherlands)

Thoolen, B.J.; Ridder, D. de; Bensing, J.; Gorter, K.; Rutten, G.

2009-01-01

This study examines the effectiveness of a brief self-management intervention to support patients recently diagnosed with type-2 diabetes to achieve sustained improvements in their self-care behaviours. Based on proactive coping, the intervention emphasizes the crucial role of anticipation and

Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.

Science.gov (United States)

Jaako, P; Debnath, S; Olsson, K; Zhang, Y; Flygare, J; Lindström, M S; Bryder, D; Karlsson, S

2015-11-01

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroid defect remain elusive. Previous studies have indicated that activation of p53 is caused by the inhibition of mouse double minute 2 (Mdm2), the main negative regulator of p53, by the 5S ribonucleoprotein particle (RNP). Meanwhile, it is not clear whether this mechanism solely mediates the p53-dependent component found in DBA. To approach this question, we crossed our mouse model for RPS19-deficient DBA with Mdm2(C305F) knock-in mice that have a disrupted 5S RNP-Mdm2 interaction. Upon induction of the Rps19 deficiency, Mdm2(C305F) reversed the p53 response and improved expansion of hematopoietic progenitors in vitro, and ameliorated the anemia in vivo. Unexpectedly, disruption of the 5S RNP-Mdm2 interaction also led to selective defect in erythropoiesis. Our findings highlight the sensitivity of erythroid progenitor cells to aberrations in p53 homeostasis mediated by the 5S RNP-Mdm2 interaction. Finally, we provide evidence indicating that physiological activation of the 5S RNP-Mdm2-p53 pathway may contribute to functional decline of the hematopoietic system in a cell-autonomous manner over time.

Prospective identification of erythroid elements in cultured peripheral blood.

Science.gov (United States)

Miller, J L; Njoroge, J M; Gubin, A N; Rodgers, G P

1999-04-01

We have developed a prospective approach to identify the generation of erythroid cells derived from cultured peripheral blood mononuclear cells (PBMC) by monitoring the expression of the cell surface protein CD48. Unpurified populations of PBMC obtained from the buffy coats of normal volunteers were grown in suspension culture in the absence or presence of erythropoietin. A profile of surface CD48 expression permitted a flow cytometric identification of erythropoietin responsive populations at various stages of their maturation. In the absence of erythropoietin (EPO) supplemented media, the CD48- cells represented <5% of the total population of PBMC remaining in culture. In cultures supplemented with 1 U/mL EPO, the mean percentage of CD48- cells increased to 34.7 + 14.9% (p < 0.01) after 14 days in culture. Coordinated CD34 and CD71 (transferrin receptor) expression, morphology, gamma-globin transcription, and colony formation in methylcellulose were observed during the 14-day culture period. Flow cytometric monitoring of bulk cultured PBMC provides a simple and reliable means for the prospective or real-time study of human erythropoiesis.

Climate change: A threat towards achieving ‘Sustainable Development Goal number two’ (end hunger, achieve food security and improved nutrition and promote sustainable agriculture in South Africa

Directory of Open Access Journals (Sweden)

Shingirai S. Mugambiwa

2017-02-01

Full Text Available This article aims to assess the impacts of climate change towards the achievement of Sustainable Development Goal number two (SDG 2 as well as examining the poverty alleviation strategies by subsistence farmers in South Africa. Widespread hunger and poverty continue to be among the most life-threatening problems confronting mankind. Available statistics show that global poverty remains a serious challenge around the world. Across the globe, one in five people lives on less than $1 a day and one in seven suffers from chronic hunger. Similarly, the developing world is adversely affected by poverty and hunger. In the sub-Saharan Africa, research has revealed a higher prevalence of hunger, malnutrition, poverty and food insecurity. SDG 2 focuses more on eliminating hunger and promoting sustainable agriculture. The study employed an exploratory design and a qualitative method. Snowball sampling was used in selecting relevant sources which led the researchers to other research work on the same field through keywords and reference lists. The researchers employed discourse analysis to analyse data. The study discovered that there are numerous potential effects climate change could have on agriculture. It affects crop growth and quality and livestock health. Farming practices could also be affected as well as animals that could be raised in particular climatic areas. The impact of climate change as well as the susceptibility of poor communities is very immense. The article concludes that climate change reduces access to drinking water, negatively affects the health of people and poses a serious threat to food security.

Dietary change – consumer preferences, marketing barriers and enablers, and the role of meat alternative choice(s) in achieving sustainable consumption

OpenAIRE

Apostolidis, Chrysostomos; McLeay, Fraser

2012-01-01

This research builds upon existing theories of consumer behaviour, sustainable and ethical consumption and social marketing. It aims to improve academic and practical understanding of the effect of socio-environmental attributes on consumer preferences regarding meat and meat alternative products and examine how more sustainable consumption patterns can be achieved. It is based upon the idea that marketing strategies can be used with the ultimate aim of changing behavior in order to benefit t...

Effects of low-level (1.0 R) x-irradiation on the erythroid response of the rat bone marrow

International Nuclear Information System (INIS)

Gong, J.K.; Glomski, C.A.; Frederiksen, N.L.; Lawson, A.J.; Daley, J.P.

1976-01-01

The levels of normoblasts in the bone marrow of six groups of female Sprague--Dawley rats previously exposed to a 1.0 R dose of x rays were compared with those in sham-exposed animals at intervals from 14 hr to 10 weeks postirradiation. Four parameters were analyzed, the percentage of normoblasts in Wright's Giemsa stained marrow smears, and the number of erythroid precursors per milligram of isolated marrow sample, per whole femur, and per entire skeleton. The studies were based on marrow examinations and on 59 Fe tracer data. At all intervals except the earliest, [14 hr], significant elevations in the percentage of normoblasts were found in the bone marrow. In addition, at 6 and 10 weeks postirradiation increases were found in the number of normoblasts in the isolated marrow samples, whole femurs, and total skeletons. When compared 81 hr after phlebotomy, subnormal increases in normoblast levels were found in all four parameters of the irradiated subjects. The results suggest that x irradiation at this dose level can induce an abnormal marrow function manifested by an elevated number of normoblasts and, after phlebotomy, by a subnormal proliferation of the erythroid precursors

[Update on the biology of heme synthesis in erythroid cells].

Science.gov (United States)

Fujiwara, Tohru; Harigae, Hideo

2015-02-01

Heme is a prosthetic group of hemoproteins playing important roles in oxygen transport, detoxification, circadian rhythm, microRNA processing, regulation of transcription, and translation. The majority of heme (-85%) is synthesized in red blood cells mainly for hemoglobin production, whereas hepatocytes account for most of the rest, functioning primarily in the synthesis of cytochrome P450 enzymes and mitochondrial respiratory enzymes. Thus, failure of heme biosynthesis causes severe inherited or acquired disorders in humans, including porphyria and sideroblastic anemia. The heme biosynthetic pathway is composed of eight enzymes that work in either mitochondria or the cytoplasm, which have been extensively researched and frequently reviewed. On the other hand, the mechanisms governing transport and intracellular trafficking of heme intermediates, as well as their potential links to human diseases, are poorly understood. Herein, we focus on recent understanding of the heme biosynthetic pathway and on human disorders due to defective heme synthesis in erythroid cells, such as X-linked sideroblastic anemia and erythropoietic protoporphyria.

Synergistic Effect of Sodium Butyrate and Thalidomide in the Induction of Fetal Hemoglobin Expression in Erythroid Progenitors Derived from Cord Blood CD133 + Cells

Directory of Open Access Journals (Sweden)

Ali Dehghanifard

2012-07-01

Full Text Available Background: The use of drugs with the ability to induce production of fetal hemoglobin as a novel therapeutic approach in treating β-Hemoglobinopathies is considered. γ-globin gene expression inducer drugs including sodium butyrate and thalidomide can reduce additional α-globin chains accumulation in erythroid precursors. Materials and Methods: In this experimental study, MACS kit was used to isolate CD133+ cells of umbilical cord blood. Further, the effect of two drugs of thalidomide and sodium butyrate were separately and combined studied on the induction of quantitative expression of β-globin and γ-globin genes in erythroid precursor cells derived from CD133+ stem cells in-vitro. For this purpose, the technique SYBR green Real-time PCR was used.Results: Flow cytometry results showed that approximately 95% of purified cells were CD133+. Real-time PCR results also showed the increased levels of γ-globin mRNA in the cell groups treated with thalidomide, sodium butyrate and combination of drugs as 2.6 and 1.2 and 3.5 times respectively, and for β-globin gene, it is respectively 1.4 and 1.3 and 1.6 times compared with the control group (p<0.05.Conclusion: The study results showed that the mentioned drug combination can act as a pharmaceutical composition affecting the induction of fetal hemoglobin expression in erythroid precursor cells derived from CD133 + cells.

Socially cooperative choices: An approach to achieving resource sustainability in the coastal zone

Science.gov (United States)

Crance, Colin; Draper, Dianne

1996-03-01

Achieving resource sustainability, particularly in the coastal zone, is complicated by a variety of interdependencies and trade-offs between economic, social, and ecological variables. Although trade-offs between each of these variables are important, this paper emphasizes the social components of resource management. In this regard a distinction is made between individual and cooperative choices. Individual choices frequently are made from a shortterm, self-interested perspective, whereas cooperative choices are made from a long-term, community and resource-sustainability perspective. Typically, when presented with a spectrum of resource management decisions, individuals have a tendency to act in a self-interested manner. Thus, cooperative benefits, such as reduced conflict and improved resource certainty, are not realized. An overview of selected aspects of social dilemma theory suggests that socially cooperative choice outcomes are attainable in coastal zone management by integrating structural and behavioral solutions in resource use decision making. Three barriers to successful integration of structural and behavioral solutions are identified as self-interest, mistrust, and variable perceptions of resource amenities. Examples from coastal zone management indicate that these barriers may be overcome using approaches such as scopereduction, co-management, community education, and local participation. The paper also provides comment on the potential benefits of integrating structural and behavioral solutions in international coastal zone management efforts.

Achieving More Sustainable Designs through a Process Synthesis-Intensification Framework

DEFF Research Database (Denmark)

Babi, Deenesh Kavi; Woodley, John; Gani, Rafiqul

2014-01-01

More sustainable process designs refer to design alternatives that correspond to lowervalues of a set of targeted performance criteria. In this paper, a multi-level frameworkfor process synthesis-intensification that leads to more sustainable process designs ispresented. At the highest level of a...

Promoting nuclear power, achieving sustainable development of nuclear industry in China

International Nuclear Information System (INIS)

Kang, R.

2006-01-01

The past 5 decades witnessed the rapid growth of China's nuclear industry. The sustained and rapid economic growth and continuous improvement of people's living standards have placed higher requirements for energy and power supplies. As a safe and clean energy source, nuclear energy has been gradually and widely accepted by the Chinese government and the public. The Chinese government has adopted the policy a ctively pushing forward the nuclear power development , set up the target to reach 40GWe of nuclear power installed capacity by 2020, accounting for about 4% of the total installed capacity in China. In this regard, this paper presents the China's nuclear program to illustrate how China is going to achieve the target. The paper is composed of 3 parts. The first part gives a review of the achievements in nuclear power in the last 20 years. The second part presents China's ''three approach'' strategy for furthering the nuclear power development: carrying out duplication projects at the existing plant sites; introducing GUI technology via international bidding; developing the brand C NP1000 , i.e. Chinese Nuclear Power lOOOMwe class, with China's own intellectual property. This part also explores the ways of securing the fuel supply for nuclear power development. The third part concludes with CNNC's ''3221'' strategy which aims at building a world class conglomerate, and expresses its sincere wish to work with the nuclear community to push the nuclear industry worldwide by strengthening international cooperation

Is sustainability achievable? Exploring the limits of sustainability with model systems.

Science.gov (United States)

Shastri, Yogendra; Diwekar, Urmila; Cabezas, Heriberto; Williamson, James

2008-09-01

Successful implementation of sustainability ideas in ecosystem management requires a basic understanding of the often nonlinear and nonintuitive relationships among different dimensions of sustainability, particularly the system-wide implications of human actions. This basic understanding further includes a sense of the time scale of possible future events and the limits of what is and is not likely to be possible. With this understanding, systematic approaches can then be used to develop policy guidelines for the system. This article presents an illustration of these ideas by analyzing an integrated ecological-economic-social model, which comprises various ecological (natural) and domesticated compartments representing species along with a macroeconomic price setting model. The stable and qualitatively realistic model is used to analyze different relevant scenarios. Apart from highlighting complex relationships within the system, it identifies potentially unsustainable future developments such as increased human per capita consumption rates. Dynamic optimization is then used to develop time-dependent policy guidelines for the unsustainable scenarios using objective functions that aim to minimize fluctuations in the system's Fisher information. The results can help to identify effective policy parameters and highlight the tradeoff between natural and domesticated compartments while managing such integrated systems. The results should also qualitatively guide further investigations in the area of system level studies and policy development.

Green innovation and sustainable industrial systems within sustainability and company improvement perspective

Science.gov (United States)

Edi Nugroho Soebandrija, Khristian

2017-12-01

This paper comprises discussion of Green Innovation and Sustainable Industrial Systems within Sustainability and Company Improvement Perspective of beverage manufacturing company (BMC). The stakeholder theory is the grand theory for the company improvement perspective in this paper. The data processing in this paper is conducted through software which are SEM-PLS with SmartPLS 2.0 and SPSS 19. The specified objective of this paper has focus on sustainability as one of 6 variables, in lieu of those 6 variables as the big picture. The reason behind this focus on sustainability is the fact that there are assorted challenges in sustainability that is ranging from economic, environment and company perspectives. Those challenges in sustainability include the sustainable service supply chain management and its involvement of society. The overall objective is to analyze relationship hypothesis of 6 variables, 4 of them (leadership, organizational learning, innovation, and performance) are based on Malcolm Baldrige’s performance excellence concept to achieve sustainability and competitive advantage through company-competitor and customer questionnaire, and its relation to Total Quality Management (TQM) and Quality Management System (QMS). In conclusion, the spearheaded of company improvement in this paper is in term of consumer satisfaction through 99.997% quality standards. These can be achieved by ambidexterity through exploitation and exploration innovation. Furthermore, in this paper, TQM enables to obtain popularity brand index achievement that is greater than 45.9%. Subsequently, ISO22000 of food security standard encompasses quality standard of ISO9000 and HACCP. Through the ambidexterity of exploitation and exploration (Non Standard Product Inspection) NOSPI machine, the company improvement generates the achievement of 75% automation, 99.997% quality control standard and 80% of waste reduction.

Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage

DEFF Research Database (Denmark)

Järås, Marcus; Johnels, Petra; Agerstam, Helena

2009-01-01

OBJECTIVE: The P190 and P210 BCR/ABL1 fusion genes are mainly associated with different types of hematologic malignancies, but it is presently unclear whether they are functionally different following expression in primitive human hematopoietic cells. MATERIALS AND METHODS: We investigated...... and systematically compared the effects of retroviral P190 BCR/ABL1 and P210 BCR/ABL1 expression on cell proliferation, differentiation, and global gene expression in human CD34(+) cells from cord blood. RESULTS: Expression of either P190 BCR/ABL1 or P210 BCR/ABL1 resulted in expansion of erythroid cells...... and stimulated erythropoietin-independent burst-forming unit-erythroid colony formation. By using a lentiviral anti-signal transducer and activator of transcription 5 (STAT5) short-hairpin RNA, we found that both P190 BCR/ABL1- and P210 BCR/ABL1-induced erythroid cell expansion were STAT5-dependent. Under...

Automated monitoring: a potential solution for achieving sustainable improvement in hand hygiene practices.

Science.gov (United States)

Levchenko, Alexander I; Boscart, Veronique M; Fernie, Geoff R

2014-08-01

Adequate hand hygiene is often considered as the most effective method of reducing the rates of hospital-acquired infections, which are one of the major causes of increased cost, morbidity, and mortality in healthcare. Electronic monitoring technologies provide a promising direction for achieving sustainable hand hygiene improvement by introducing the elements of automated feedback and creating the possibility to automatically collect individual hand hygiene performance data. The results of the multiphase testing of an automated hand hygiene reminding and monitoring system installed in a complex continuing care setting are presented. The study included a baseline Phase 1, with the system performing automated data collection only, a preintervention Phase 2 with hand hygiene status indicator enabled, two intervention Phases 3 and 4 with the system generating hand hygiene reminding signals and periodic performance feedback sessions provided, and a postintervention Phase 5 with only hand hygiene status indicator enabled and no feedback sessions provided. A significant increase in hand hygiene performance observed during the first intervention Phase 3 was sustained over the second intervention Phase 4, with the postintervention phase also indicating higher hand hygiene activity rates compared with the preintervention and baseline phases. The overall trends observed during the multiphase testing, the factors affecting acceptability of the automated hand hygiene monitoring system, and various strategies of technology deployment are discussed.

Managing product returns to achieve supply chain sustainability

DEFF Research Database (Denmark)

Shaharudin, Mohd Rizaimy; Govindan, Kannan; Zailani, Suhaiza

2015-01-01

returns management as part of a comprehensive sustainability effort. The study is exploratory in nature based on five case studies of participating manufacturers in the automotive, and electrical and electronics industry in Malaysia. The interview results reveal that the five participating companies...

Sustained availability of trimethoprim in drinking water to achieve higher plasma sulphonamide-trimethoprim antibacterial activity in broilers.

Science.gov (United States)

Sumano, H; Hernandez, L; Gutierrez, L; Bernad-Bernad, M J

2005-02-01

(1) In order to make trimethoprim (TMP) available to broilers throughout the day, a sustained release formulation (SRF) of the drug in the form of granules was added to the water tank that supplies drinking water. (2) Broilers were initially dosed with sulphachloropiridazine-TMP (SCP-TMP 5:1) and then further medicated throughout the day, achieving in the end a dose of 30 mg/kg each of SCP and TMP (group A). Group B received a preparation with the same dose of SCP and TMP (1:1) as group A, but administered as a single dose without the SRF of TMP. Group C received the customary SCP-TMP 5:1 preparation (30 and 6 mg/kg, respectively). Water tanks were completely consumed in 3 to 4 h. (3) Broilers were bled at different times and concentration of antibacterial activity in serum determined by correlating the composite antibacterial activity of SCP and TMP with actual concentrations of these drugs by means of a microbiological agar diffusion assay. (4) Time vs serum concentrations of activity were higher in group B; the increments in the maximum serum concentration for group B over groups A and C being 39 and 67%, respectively. (5) However, the sustained concentration of activity over time, measured as the area under the cu)rve, was highest in group A. Group B had higher values for area under the curve than group C. (6) An additional dose of TMP to achieve 30 mg/kg of both SCP and TMP improves the serum concentration of this combination over the customary 5:1 proportion. The best values for sustaining antibacterial activity were obtained using a 1:1 ratio as in group A. The use of a SRF as in group A may translate into better clinical results.

The Role of Public Health Nutrition in Achieving the Sustainable Development Goals in the Asia Pacific Region.

Science.gov (United States)

Binns, Colin; Lee, Mi Kyung; Low, Wah Yun; Zerfas, Alfred

2017-10-01

The Sustainable Development Goals (SDGs) replaced the Millennium Development Goals (MDCs) in 2015, which included several goals and targets primarily related to nutrition: to eradicate extreme poverty and hunger and to reduce child mortality and improve maternal health. In the Asia-Pacific Academic Consortium for Public Health (APACPH) member countries as a group, infant and child mortality were reduced by more than 65% between 1990 and 2015, achieving the MDG target of two-thirds reduction, although these goals were not achieved by several smaller countries. The SDGs are broader in focus than the MDGs, but include several goals that relate directly to nutrition: 2 (zero hunger-food), 3 (good health and well-being-healthy life), and 12 (responsible consumption and production-sustainability). Other SDGs that are closely related to nutrition are 4 and 5 (quality education and equality in gender-education and health for girls and mothers, which is very important for infant health) and 13 (climate action). Goal 3 is "good health and well-being," which includes targets for child mortality, maternal mortality, and reducing chronic disease. The Global Burden of Disease Project has confirmed that the majority of risk for these targets can be attributed to nutrition-related targets. Dietary Guidelines were developed to address public health nutrition risk in the Asia Pacific region at the 48th APACPH 2016 conference and they are relevant to the achievement of the SDGs. Iron deficiency increases the risk of maternal death from haemorrhage, a cause of 300000 deaths world-wide each year. Improving diets and iron supplementation are important public health interventions in the APACPH region. Chronic disease and obesity rates in the APACPH region are now a major challenge and healthy life course nutrition is a major public health priority in answering this challenge. This article discusses the role of public health nutrition in achieving the SDGs. It also examines the role of

Crossing scales and disciplines to achieve forest sustainability

Science.gov (United States)

Michael J. Papaik; Brian Sturtevant; Christian Messier

2008-01-01

Forest land managers are faced with unprecedented global pressures to produce resources for human consumption (e.g., Liu and Diamond 2005), while still maintaining essential ecosystem services benefiting society at multiple spatial scales (Costanza et al. 1997). These global pressures alone present daunting challenges to sustainable forest management (SFM) worldwide (...

Delayed Mesoderm and Erythroid Differentiation of Murine Embryonic Stem Cells in the Absence of the Transcriptional Regulator FUBP1

Directory of Open Access Journals (Sweden)

Josephine Wesely

2017-01-01

Full Text Available The transcriptional regulator far upstream binding protein 1 (FUBP1 is essential for fetal and adult hematopoietic stem cell (HSC self-renewal, and the constitutive absence of FUBP1 activity during early development leads to embryonic lethality in homozygous mutant mice. To investigate the role of FUBP1 in murine embryonic stem cells (ESCs and in particular during differentiation into hematopoietic lineages, we generated Fubp1 knockout (KO ESC clones using CRISPR/Cas9 technology. Although FUBP1 is expressed in undifferentiated ESCs and during spontaneous differentiation following aggregation into embryoid bodies (EBs, absence of FUBP1 did not affect ESC maintenance. Interestingly, we observed a delayed differentiation of FUBP1-deficient ESCs into the mesoderm germ layer, as indicated by impaired expression of several mesoderm markers including Brachyury at an early time point of ESC differentiation upon aggregation to EBs. Coculture experiments with OP9 cells in the presence of erythropoietin revealed a diminished differentiation capacity of Fubp1 KO ESCs into the erythroid lineage. Our data showed that FUBP1 is important for the onset of mesoderm differentiation and maturation of hematopoietic progenitor cells into the erythroid lineage, a finding that is supported by the phenotype of FUBP1-deficient mice.

Roadmap to sustainable textiles and clothing regulatory aspects and sustainability standards of textiles and the clothing supply chain

CERN Document Server

2015-01-01

This book covers the elements involved in achieving sustainability in textiles and clothing sector. The chapters covered in three volumes of this series title cover all the distinctive areas earmarked for achieving sustainable development in textiles and clothing industry. This third volume highlights the areas pertaining to the regulatory aspects and sustainability standards applicable to textiles and clothing supply chain. There are various standards earmarked for measuring the environmental impacts and sustainability of textile products. There are also plenty of certification schemes available along with the index systems applicable to textile sector. Brands and manufactures are also venturing into new developments to achieve sustainable development in textile sector. This third volume addresses all these important aspects.

Achieving and sustaining full employment.

Science.gov (United States)

Rosen, S M

1995-01-01

Human rights and public health considerations provide strong support for policies that maximize employment. Ample historical and conceptual evidence supports the feasibility of full employment policies. New factors affecting the labor force, the rate of technological change, and the globalization of economic activity require appropriate policies--international as well as national--but do not invalidate the ability of modern states to apply the measures needed. Among these the most important include: (I) systematic reduction in working time with no loss of income, (2) active labor market policies, (3) use of fiscal and monetary measures to sustain the needed level of aggregate demand, (4) restoration of equal bargaining power between labor and capital, (5) social investment in neglected and outmoded infrastructure, (6) accountability of corporations for decisions to shift or reduce capital investment, (7) major reductions in military spending, to be replaced by socially needed and economically productive expenditures, (8) direct public sector job creation, (9) reform of monetary policy to restore emphasis on minimizing unemployment and promoting full employment. None are without precedent in modern economies. The obstacles are ideological and political. To overcome them will require intellectual clarity and effective advocacy.

Role of the mitochondrial amino acid pool in the differential sensitivity of erythroid and myeloid cells to chloramphenicol

International Nuclear Information System (INIS)

Abou-Khalil, S.; Abou-Khalil, W.H.; Whitney, P.L.; Yunis, A.A.

1986-01-01

Previous studies in the authors laboratory have suggested that mitochondrial amino acid (AA) pool is involved in the differential sensitivity of erythroid and myeloid cells to chloramphenicol (CAP). The present study examines the role of AA pool by analysis of its composition and testing the effects of its major components. The endogenous AA composition of isolated mitochondria protein was determined using a JEOL 5AH AA analyzer. L-( 14 C) leucine incorporation into mitochondrial protein was used to measure the rate of protein synthesis. Analysis of the endogenous pool in erythroleukemia (EM) and chloroleukemia (CM) mitochrondria showed similar total amount of AAs. However, some AAs were present in significantly higher or lower quantity within EM and CM (i.e. EM had about 2-fold higher glycine content). When compensating for each low AA addition of that particular acid to the reaction medium, only glycine and serine had significant effect. Thus, the addition of increasing concentrations of glycine or serine enhanced the sensitivity to CAP from 14% to 49-51% in CM but not in EM. Other AAs gave little or no effect. Since glycine is one of the first reactants in heme biosynthesis within mitochondria and is interconvertible with serine, it would appear that erythroid cells sensitivity to CAP is determined by the mitochondrial glycine-serine pool and may be somehow related of the pathway to heme biosynthesis in these cells

Ecological Footprints and Lifestyle Archetypes: Exploring Dimensions of Consumption and the Transformation Needed to Achieve Urban Sustainability

Directory of Open Access Journals (Sweden)

Jennie Moore

2015-04-01

Full Text Available The global urban transition increasingly positions cities as important influencers in determining sustainability outcomes. Urban sustainability literature tends to focus on the built environment as a solution space for reducing energy and materials demand; however, equally important is the consumption characteristics of the people who occupy the city. While size of dwelling and motor vehicle ownership are partially influenced by urban form, they are also influenced by cultural and socio-economic characteristics. Dietary choices and purchases of consumable goods are almost entirely driven by the latter. Using international field data that document urban ways of living, I develop lifestyle archetypes coupled with ecological footprint analysis to develop consumption benchmarks in the domains of: food, buildings, consumables, transportation, and water that correspond to various levels of demand on nature’s services. I also explore the dimensions of transformation that would be needed in each of these domains for the per capita consumption patterns of urban dwellers to achieve ecological sustainability. The dimensions of transformation needed commensurate with ecological carrying capacity include: a 73% reduction in household energy use, a 96% reduction in motor vehicle ownership, a 78% reduction in per capita vehicle kilometres travelled, and a 79% reduction in air kilometres travelled.

Sustainable flood risk management – What is sustainable?

DEFF Research Database (Denmark)

Sørup, Hjalte Jomo Danielsen; Brudler, Sarah; Lerer, Sara Maria

2016-01-01

Sustainable flood risk management has to be achieved since flood protection is a fundamental societal service that we must deliver. Based on the discourse within the fields of risk management and sustainable urban water management, we discuss the necessity of assessing the sustainability of flood...... risk management, and propose an evaluation framework for doing so. We argue that it is necessary to include quantitative sustainability measures in flood risk management in order to exclude unsustainable solutions. Furthermore, we use the concept of absolute sustainability to discuss the prospects...... of maintaining current service levels without compromising future generation’s entitlement of services. Discussions on the sustainability of different overall flood risk schemes must take place. Fundamental changes in the approaches will require fundamental changes in the mind-sets of practitioners as well...

The role of social message using norm abstraction level and ecological value orientation to achieve sustainable consumption

Science.gov (United States)

Ekasari, A.

2018-01-01

Pro-environmental behavior is one of human activities to achieve sustainability. In order to encourage people to do so, it needs contribution from marketing discipline using social message. The research aims to investigate the effect of social message framed by norm abstraction level and ecological value orientation on attitude and intention to act pro-environmental behavior in the context of littering. This study implemented a 3 (message framing: biospheric/altruistic/egoistic) × 2 (norm abstraction level : abstract/concrete) between subject experimental design to collect the data. An independent sample t test was used to analyze the data. The results indicate that a social message using concrete norm combined with the three ecological value orientation gains more positive response than the use of abstract norm with the same ecological value orientations. Findings of the research are expected to help government or other institutions to create an appropriate social message in anti littering campaign and motivates people to change their behavior in practicing sustainable consumption.

The role of science in achieving sustainability

International Nuclear Information System (INIS)

Dragan, Gleb

2004-01-01

Over the last few decades research in the natural sciences has unveiled a number of specific complex relations between human activity an environmental change on a global scale. Scientific assesment confirm that global life support systems, such as climate, biodiversity and water resources are significantly affected by human activities. System change became the key in the research plan that emerged - systems being defined as the socio-economic and technical chains of production, distribution, consumption and disposal activities. Predicting the impact of a changing world on human health is a hard task and requires an interdisciplinary approach drawn from the fields of evaluation, biogeography, ecology and social sciences, and relying on various methodologies such as mathematical modelling as well as historical analysis. However, the great majority of public health researchers are empiricists by training and tradition, studying the past and the present via direct observation. By definition empirical methods cannot be used to study the future. To extent that the advent of global environmental changes obliges scientists to estimate future impacts, should current or foreseeable trends continue, then empiricism must be supplemented by integrated assessment modelling. The prediction of environmental change and its health impacts encounters uncertainties at various level. Some of the uncertainties are of scientific kind or are referring to the conceptualisation and construction of mathematical models where the specification of linked processes may be uncertain. Research on transformation towards sustainability puts emphasis on the interaction of innovation (production), consumption and institution and incentive structure. The specific challenges and research needs are: - Understand the dynamics of structural change in sociotechno-ecological system and anticipate transformation paths (knowledge of system dynamics); - Assess and evaluate the impacts of specific paths of

36 CFR 219.20 - Ecological sustainability.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Ecological sustainability... Sustainability § 219.20 Ecological sustainability. To achieve ecological sustainability, the responsible official... diversity and species diversity are components of ecological sustainability. The planning process must...

The effect of ceruloplasmin on erythroid precursor cells in the marrow of irradiated mice

International Nuclear Information System (INIS)

Suda, Toshio; Miura, Yasusada; Ozawa, Keiya; Yamada, Masaaki.

1981-01-01

The effect of ceruloplasmine on erythroid colony forming unit (CFU-e) of irradiated mice was investigated. Whole body #betta# ray irradiation of 100rad decreased the number of CFU-e from 154 to 40 per 4 * 10 4 myeloid nucleated cells. When human #betta#-globulin of 1 mg/kg or ceruloplasmin of 1 mg/kg was administrated immediately after irradiation, the number of CFU-e increased to that of more than normal and normal value in 2 days, respectively. In the case where ceruloplasmin was begun to administrated 7 days before irradiation, though the CFU-e number decreased from 144 to 44, the number increased to 317 after 2 days, and gradually decreased to the normal value by 16 days after irradiation. (Nakanishi, T)

An international waste convention: measures for achieving sustainable development.

Science.gov (United States)

Meyers, Gary D; McLeod, Glen; Anbarci, Melanie A

2006-12-01

Waste is a by-product of economic growth. Consequently, economic growth presents challenges for sustainable resource management and development because continued economic growth implies continued growth in waste outputs. Poor management of waste results in the inappropriate depletion of natural resources and potentially adverse effects on the environment, health and the economy. It is unsustainable. This paper begins by outlining the magnitude of and the current response to the growth in the quantity of waste outputs. This is followed by a consideration of why the international response to date, including the Rio Declaration and Agenda 21, fails to address the issue adequately. The paper concludes with a discussion on why and how an international treaty or other measure could advance sustainable development by providing an appropriate framework within which to address the problem.

Identification of Stages of Erythroid Differentiation in Bone Marrow and Erythrocyte Subpopulations in Blood Circulation that Are Preferentially Lost in Autoimmune Hemolytic Anemia in Mouse.

Directory of Open Access Journals (Sweden)

Sreoshi Chatterjee

Full Text Available Repeated weekly injections of rat erythrocytes produced autoimmune hemolytic anemia (AIHA in C57BL/6 mice after 5-6 weeks. Using the double in vivo biotinylation (DIB technique, recently developed in our laboratory, turnover of erythrocyte cohorts of different age groups during AIHA was monitored. Results indicate a significant decline in the proportion of reticulocytes, young and intermediate age groups of erythrocytes, but a significant increase in the proportion of old erythrocytes in blood circulation. Binding of the autoantibody was relatively higher to the young erythrocytes and higher levels of intracellular reactive oxygen species (ROS were also seen in these cells. Erythropoietic activity in the bone marrows and the spleen of AIHA induced mice was examined by monitoring the relative proportion of erythroid cells at various stages of differentiation in these organs. Cells at different stages of differentiation were enumerated flow cytometrically by double staining with anti-Ter119 and anti-transferrin receptor (CD71 monoclonal antibodies. Erythroid cells in bone marrow declined significantly in AIHA induced mice, erythroblast C being most affected (50% decline. Erythroblast C also recorded high intracellular ROS level along with increased levels of membrane-bound autoantibody. No such decline was observed in spleen. A model of AIHA has been proposed indicating that binding of autoantibodies may not be a sufficient condition for destruction of erythroid cells in bone marrow and in blood circulation. Last stage of erythropoietic differentiation in bone marrow and early stages of erythrocytes in blood circulation are specifically susceptible to removal in AIHA.

Comparison of different methods for erythroid differentiation in the K562 cell line.

Science.gov (United States)

Shariati, Laleh; Modaress, Mehran; Khanahmad, Hossein; Hejazi, Zahra; Tabatabaiefar, Mohammad Amin; Salehi, Mansoor; Modarressi, Mohammad Hossein

2016-08-01

To compare methods for erythroid differentiation of K562 cells that will be promising in the treatment of beta-thalassemia by inducing γ-globin synthesis. Cells were treated separately with: RPMI 1640 medium without glutamine, RPMI 1640 medium without glutamine supplemented with 1 mM sodium butyrate, RPMI 1640 medium supplemented with 1 mM sodium butyrate, 25 µg cisplatin/ml, 0.1 µg cytosine arabinoside/ml. The highest differentiation (84 %) with minimum toxicity was obtained with cisplatin at 15 µg /ml. Real-time RT-PCR showed that expression of the γ-globin gene was significantly higher in the cells differentiated with cisplatin compared to undifferentiated cells (P < 0.001). Cisplatin is useful in the experimental therapy of ß-globin gene defects and can be considered for examining the basic mechanism of γ-reactivation.

Sustainable architecture and the Passive House concept: achievements and failures on energy matters

OpenAIRE

Van Moeseke, Geoffrey; PLEA2011 Conference

2011-01-01

The Passive House approach meets increasing success and will continue to spread in coming years. But conceptual thinking about sustainable architecture also goes forward. This paper intends to confront the Passive House approach with 5 principles of sustainability. These principles are based on de Myttenaere’s attempt to give a holistic definition of sustainable architecture. Although sustainability is a very large concern, only energy related matters are examined. This paper concludes on rec...

Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders.

Science.gov (United States)

Woo, Yu Ri; Hwang, Sewon; Jeong, Seo Won; Cho, Dae Ho; Park, Hyun Jeong

2017-02-03

Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders.

Early stage design decisions: the way to achieve sustainable buildings at lower costs.

Science.gov (United States)

Bragança, Luís; Vieira, Susana M; Andrade, Joana B

2014-01-01

The construction industry attempts to produce buildings with as lower environmental impact as possible. However, construction activities still greatly affect environment; therefore, it is necessary to consider a sustainable project approach based on its performance. Sustainability is an important issue to consider in design, not only due to environmental concerns but also due to economic and social matters, promoting architectural quality and economic advantages. This paper aims to identify the phases through which a design project should be developed, emphasising the importance and ability of earlier stages to influence sustainability, performance, and life cycle cost. Then, a selection of sustainability key indicators, able to be used at the design conceptual phase and able to start predicting environmental sustainability performance of buildings is presented. The output of this paper aimed to enable designers to compare and evaluate the consequences of different design solutions, based on preliminary data, and facilitate the collaboration between stakeholders and clients and eventually yield a sustainable and high performance building throughout its life cycle.

Nuclear RNA sequencing of the mouse erythroid cell transcriptome.

Directory of Open Access Journals (Sweden)

Jennifer A Mitchell

Full Text Available In addition to protein coding genes a substantial proportion of mammalian genomes are transcribed. However, most transcriptome studies investigate steady-state mRNA levels, ignoring a considerable fraction of the transcribed genome. In addition, steady-state mRNA levels are influenced by both transcriptional and posttranscriptional mechanisms, and thus do not provide a clear picture of transcriptional output. Here, using deep sequencing of nuclear RNAs (nucRNA-Seq in parallel with chromatin immunoprecipitation sequencing (ChIP-Seq of active RNA polymerase II, we compared the nuclear transcriptome of mouse anemic spleen erythroid cells with polymerase occupancy on a genome-wide scale. We demonstrate that unspliced transcripts quantified by nucRNA-seq correlate with primary transcript frequencies measured by RNA FISH, but differ from steady-state mRNA levels measured by poly(A-enriched RNA-seq. Highly expressed protein coding genes showed good correlation between RNAPII occupancy and transcriptional output; however, genome-wide we observed a poor correlation between transcriptional output and RNAPII association. This poor correlation is due to intergenic regions associated with RNAPII which correspond with transcription factor bound regulatory regions and a group of stable, nuclear-retained long non-coding transcripts. In conclusion, sequencing the nuclear transcriptome provides an opportunity to investigate the transcriptional landscape in a given cell type through quantification of unspliced primary transcripts and the identification of nuclear-retained long non-coding RNAs.

ECO-INNOVATION FOR A SUSTAINABLE FUTURE

Directory of Open Access Journals (Sweden)

RATIU Mariana

2014-05-01

Full Text Available Eco-innovation is any form of innovation resulting in or aiming at significant and demonstrable progress towards the goal of sustainable development, through reducing impacts on the environment, enhancing resilience to environmental pressures, or achieving a more efficient and responsible use of natural resources. States and governments of the world, different institutions and organizations actively involved and aware in public policies, strategies and actions, reaffirm their commitments and reassess actions in order to achieve a truly sustainable development. In the common vision and the resolutions and other documents of the United Nations Conference on Sustainable Development, Rio+20, the words "environment", "innovation", "green economy" appear very often and almost always along the same context, to achieve the objectives of the sustainable development. The objectives of EU's Europe 2020 strategy for smart, sustainable and inclusive growth, are being implemented through a number of Flagship Initiatives addressing the main challenges, like “Innovation for a sustainable Future - The Eco-innovation Action Plan (EcoAP”. Eco-innovation Observatory developed the Eco-Innovation index, the first tool to assess and illustrate eco-innovation performance across the EU Member States. Like in all fields, in textiles and leather field, eco-innovation is present and there are a lot of tools available that measure environmental damage and help manufacturers and brands become more sustainable. Eco-innovation is not just a trendy concept but a reality and a necessity nowadays, a way to achieve a sustainable future for ourselves and future generations.

KINGS Model: Achieving Sustainable Change in Nuclear Engineering Education for the Post-COP21 Era

International Nuclear Information System (INIS)

Oh, S.-K.

2016-01-01

Full text: In spite of the world nuclear community’s systematic and multilateral efforts during the COP21, most of the conference participants were reluctant to acknowledge the value of nuclear as a low-carbon energy source. In fact, the on-going aftermath of the Fukushima nuclear disaster has been overwhelming despite the evidence that there was neither any critical technical flaw nor fatal radiation casualties. This shows that advanced nuclear knowledge failed to resonate with public perception on nuclear energy. In this respect, it is now time to focus on achieving sustainable change in nuclear engineering education for the future. The KEPCO International Nuclear Graduate School (KINGS) was established to nurture leadership-level nuclear power professionals in the global standard. It affiliates with Korean nuclear industry to achieve three major goals that are also a universal prerequisite for higher education of engineering in the 21st century as follows: “a balance between education and training,” “harmony between engineering and managerial skills,” and “the application of systems engineering to nuclear power projects.” KINGS curriculum requires transdisciplinary coordination among engineering disciplines, engineering specialties, and socioeconomic methods. (author

LCA and Sustainability

DEFF Research Database (Denmark)

Moltesen, Andreas; Bjørn, Anders

2018-01-01

LCA is often presented as a sustainability assessment tool. This chapter analyses the relationship between LCA and sustainability. This is done by first outlining the history of the sustainability concept, which gained momentum with the Brundtland Commission’s report ‘Our Common Future report...... is then demonstrated, and the strategy of LCA to achieving environmental protection, namely to guide the reduction of environmental impacts per delivery of a function, is explained. The attempt to broaden the scope of LCA, beyond environmental protection, by so-called life cycle sustainability assessment (LCSA......) is outlined. Finally, the limitations of LCA in guiding a sustainable development are discussed....

Early Stage Design Decisions: The Way to Achieve Sustainable Buildings at Lower Costs

Directory of Open Access Journals (Sweden)

Luís Bragança

2014-01-01

Full Text Available The construction industry attempts to produce buildings with as lower environmental impact as possible. However, construction activities still greatly affect environment; therefore, it is necessary to consider a sustainable project approach based on its performance. Sustainability is an important issue to consider in design, not only due to environmental concerns but also due to economic and social matters, promoting architectural quality and economic advantages. This paper aims to identify the phases through which a design project should be developed, emphasising the importance and ability of earlier stages to influence sustainability, performance, and life cycle cost. Then, a selection of sustainability key indicators, able to be used at the design conceptual phase and able to start predicting environmental sustainability performance of buildings is presented. The output of this paper aimed to enable designers to compare and evaluate the consequences of different design solutions, based on preliminary data, and facilitate the collaboration between stakeholders and clients and eventually yield a sustainable and high performance building throughout its life cycle.

Early Stage Design Decisions: The Way to Achieve Sustainable Buildings at Lower Costs

Science.gov (United States)

Bragança, Luís; Vieira, Susana M.; Andrade, Joana B.

2014-01-01

The construction industry attempts to produce buildings with as lower environmental impact as possible. However, construction activities still greatly affect environment; therefore, it is necessary to consider a sustainable project approach based on its performance. Sustainability is an important issue to consider in design, not only due to environmental concerns but also due to economic and social matters, promoting architectural quality and economic advantages. This paper aims to identify the phases through which a design project should be developed, emphasising the importance and ability of earlier stages to influence sustainability, performance, and life cycle cost. Then, a selection of sustainability key indicators, able to be used at the design conceptual phase and able to start predicting environmental sustainability performance of buildings is presented. The output of this paper aimed to enable designers to compare and evaluate the consequences of different design solutions, based on preliminary data, and facilitate the collaboration between stakeholders and clients and eventually yield a sustainable and high performance building throughout its life cycle. PMID:24578630

Pathways to achieve a set of ambitious global sustainability objectives by 2050

NARCIS (Netherlands)

Vuuren, van D.P.; Kok, Marcel; Lucas, P.L.; Prins, Anne Gerdien; Alkemade, Rob; Berg, van den Maurits; Bouwman, Lex; Esch, van der Stefan; Jeuken, Michel; Kram, Tom; Stehfest, Elke

2015-01-01

In 2012, governments worldwide renewed their commitments to a more sustainable development that would eradicate poverty, halt climate change and conserve ecosystems, and initiated a process to create a long-term vision by formulating Sustainable Development Goals (SDGs). Although progress in

Role of continual environmental performance improvement in achieving sustainability in uranium production

International Nuclear Information System (INIS)

Jarrell, J.P.; Chad, G.M.S.

2002-01-01

Although the term sustainable development is commonly used today, there is not yet a commonly accepted definition. Various ways of measuring sustainability have been proposed. To show how these issues are being effectively addressed in modern uranium developments, we will review some methods of defining the environmental component of sustainable development in the mining and mineral-processing sector. Environmental impacts associated with uranium extraction and processing in modern facilities are modest. Air and water emissions are well controlled. Waste materials are subject to comprehensive management programmes. The size of the impacted area is smaller than in other energy sectors, providing good opportunity to minimize land impact. Experience over the past three decades facilitated gradual, persistent, but cumulatively significant environmental improvements in the uranium production sector. Cameco's uranium mining and processing facilities exemplify these improvements. These improvements can be expected to continue, supporting our argument of Cameco's environmental sustainability. (author)

Sustainable Transportation

DEFF Research Database (Denmark)

Hall, Ralph P.; Gudmundsson, Henrik; Marsden, Greg

2014-01-01

The transportation system is the backbone of economic and social progress and the means by which humans access goods and services and connect with one another. Yet, as the scale of transportation activities has grown worldwide, so too have the negative environmental, social, and economic impacts...... that relate to the construction and maintenance of transportation infrastructure and the operation or use of the different transportation modes. The concept of sustainable transportation emerged in response to these concerns as part of the broader notion of sustainable development. Given the transportation...... sector’s significant contribution to global challenges such as climate change, it is often said that sustainable development cannot be achieved without sustainable transportation....

A Longitudinal Study of School Districts' Sustained Improvement

Science.gov (United States)

Sampson, Pauline M.

2011-01-01

In this longitudinal study of one region in the state of Texas, there was an examination of district leadership and the sustaining of high student achievement for their districts. The results of this study suggest that sustained improvement of student achievement is very difficult. The districts that had sustained improvement had stable district…

Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis

NARCIS (Netherlands)

von Lindern, M.; Deiner, E. M.; Dolznig, H.; Parren-van Amelsvoort, M.; Hayman, M. J.; Mullner, E. W.; Beug, H.

2001-01-01

Primary erythroid progenitors can be expanded by the synergistic action of erythropoietin (Epo), stem cell factor (SCF) and glucocorticoids. While Epo is required for erythropoiesis in general, glucocorticoids and SCF mainly contribute to stress erythropoiesis in hypoxic mice. This ability of normal

Achieving Sustainable Development Goals from a Water Perspective

Directory of Open Access Journals (Sweden)

Anik Bhaduri

2016-10-01

Full Text Available Efforts to meet human water needs only at local scales may cause negative environmental externality and stress on the water system at regional and global scales. Hence, assessing SDG targets requires a broad and in-depth knowledge of the global to local dynamics of water availability and use. Further, Interconnection and trade-offs between different SDG targets may lead to sub-optimal or even adverse outcome if the set of actions are not properly pre-designed considering such interlinkages. Thus scientific research and evidence have a role to play in facilitating the implementation of SDGs through assessments and policy engagement from global to local scales. The paper addresses some of these challenges related to implementation and monitoring the targets of the Sustainable Development Goals from a water perspective, based on the key findings of a conference organised in 2015 with the focus on three essential aspects of SDGs- indicators, interlinkages and implementation. The paper discusses that indicators should not be too simple but ultimately deliver sustainability measures. The paper finds that remote sensing and earth observation technologies can play a key role in supporting the monitoring of water targets. It also recognises that implementing SDGs is a societal process of development, and there is need to link how SDGs relate to public benefits and communicate this to the broader public.

Water Sciences - Connecting the dots to achieve the 2030 Agenda for Sustainable Development

Science.gov (United States)

Uhlenbrook, Stefan; Ortigara, Angela; Minelli, Lucilla

2017-04-01

Land use change, urbanisation, climate change, demographic development and migration, conflicts and peace, change of diets, industry 4.0, globalisation etc. are among the challenges that water sciences need to address to serve societal needs. Water availability per capita is decreasing, water quality is deteriorating at many places, but water demand is continuously escalating. Business as usual in water science is not up to the related challenges. In fact, business as usual cannot be the answer in all aspects, i.e. also current policy making processes will need to improve and take stock of evidences provided by science in order to better address societal challenges. However, exciting developments have been taking place. The global community agreed on a new and ambitious agenda for development, which aims to be comprehensive and include the participation of all stakeholders in one integrated framework. The 2030 Agenda for Sustainable Development provides a stimulating new era, with unique opportunities to reconcile science, society and policy making. Hydrology and water management - in all its facets including wastewater - play a central role in the Agenda 2030, as it is not only central in Sustainable Development Goal (SDG) 6, but it is fundamental for the realization of other SDGs related to, for instance, poverty reduction, sustainable growth, health, food security, climate change, ecosystems (land and sea), gender equality, etc. Despite the recognition of the critical importance of water in this agenda, the implementation of related policies and use of scientific developments represent a difficult task. Two main challenges remain: (i) the utilization of the knowledge and developments already available, and (ii) the need to overcome current and future knowledge gaps ensuring that scientific results support sustainable development effectively. The UN system will produce a Synthesis Report for SDG 6, which is currently being prepared by a UN-Water Task Force that

Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo.

Science.gov (United States)

Ogawa, Tatsuya; Tsuji-Kawahara, Sachiyo; Yuasa, Takae; Kinoshita, Saori; Chikaishi, Tomomi; Takamura, Shiki; Matsumura, Haruo; Seya, Tsukasa; Saga, Toshihiko; Miyazawa, Masaaki

2011-06-01

Natural killer (NK) cells function as early effector cells in the innate immune defense against viral infections and also participate in the regulation of normal and malignant hematopoiesis. NK cell activities have been associated with early clearance of viremia in experimental simian immunodeficiency virus and clinical human immunodeficiency virus type 1 (HIV-1) infections. We have previously shown that NK cells function as major cytotoxic effector cells in vaccine-induced immune protection against Friend virus (FV)-induced leukemia, and NK cell depletion totally abrogates the above protective immunity. However, how NK cells recognize retrovirus-infected cells remains largely unclear. The present study demonstrates a correlation between the expression of the products of retinoic acid early transcript-1 (RAE-1) genes in target cells and their susceptibility to killing by NK cells isolated from FV-infected animals. This killing was abrogated by antibodies blocking the NKG2D receptor in vitro. Further, the expression of RAE-1 proteins on erythroblast surfaces increased early after FV inoculation, and administration of an RAE-1-blocking antibody resulted in increased spleen infectious centers and exaggerated pathology, indicating that FV-infected erythroid cells are recognized by NK cells mainly through the NKG2D-RAE-1 interactions in vivo. Enhanced retroviral replication due to host gene-targeting resulted in markedly increased RAE-1 expression in the absence of massive erythroid cell proliferation, indicating a direct role of retroviral replication in RAE-1 upregulation.

Digital sustainability: basic conditions for sustainable digital artifacts and their ecosystems

OpenAIRE

Stürmer, Matthias; Abu-Tayeh, Gabriel; Myrach, Thomas

2017-01-01

The modern age has heralded a shift from the industrial society, in which natural resources are crucial input factors for the economy, towards a knowledge society. To date, sustainability literature has treated knowledge—and in particular digital artifacts—mainly as a means to the end of achieving sustainable development. In this conceptual paper, we argue that digital artifacts themselves ought also to be considered as resources, which also need to be sustainable. While over-consumption is a...

Staircase To Sustainable Development

Directory of Open Access Journals (Sweden)

Doorasamy Mishelle

2015-06-01

Full Text Available The aim of this article to provide a theoretical framework on the concepts of Sustainable Development and the process that companies need to follow in order to ensure the future sustainability of business operations. Various secondary sources and previous literature was reviewed to clearly identify why companies are finding it difficult to conduct their business operations in a sustainable manner. Stricter legislation and regulations, increased competition, depletion of natural resources and market pressures have placed organisations under increased pressure to improve environmental performance and achieve eco-efficiency. This paper provides comprehensive overview of how companies can achieve the ‘Triple bottom line’ by committing to continuous improvement and adhering to the regulations stipulated according to the International Standards of Organisations (ISO14001.

Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.

Science.gov (United States)

Promsote, Wanwisa; Makala, Levi; Li, Biaoru; Smith, Sylvia B; Singh, Nagendra; Ganapathy, Vadivel; Pace, Betty S; Martin, Pamela M

2014-05-13

Sickle retinopathy (SR) is a major cause of vision loss in sickle cell disease (SCD). There are no strategies to prevent SR and treatments are extremely limited. The present study evaluated (1) the retinal pigment epithelial (RPE) cell as a hemoglobin producer and novel cellular target for fetal hemoglobin (HbF) induction, and (2) monomethylfumarate (MMF) as an HbF-inducing therapy and abrogator of oxidative stress and inflammation in SCD retina. Human globin gene expression was evaluated by RT-quantitative (q)PCR in the human RPE cell line ARPE-19 and in primary RPE cells isolated from Townes humanized SCD mice. γ-Globin promoter activity was monitored in KU812 stable dual luciferase reporter expressing cells treated with 0 to 1000 μM dimethylfumarate, MMF, or hydroxyurea (HU; positive control) by dual luciferase assay. Reverse transcriptase-qPCR, fluorescence-activated cell sorting (FACS), immunofluorescence, and Western blot techniques were used to evaluate γ-globin expression and HbF production in primary human erythroid progenitors, ARPE-19, and normal hemoglobin producing (HbAA) and homozygous β(s) mutation (HbSS) RPE that were treated similarly, and in MMF-injected (1000 μM) HbAA and HbSS retinas. Dihydroethidium labeling and nuclear factor (erythroid-derived 2)-like 2 (Nrf2), IL-1β, and VEGF expression were also analyzed. Retinal pigment epithelial cells express globin genes and synthesize adult and fetal hemoglobin MMF stimulated γ-globin expression and HbF production in cultured RPE and erythroid cells, and in HbSS mouse retina where it also reduced oxidative stress and inflammation. The production of hemoglobin by RPE suggests the potential involvement of this cell type in the etiology of SR. Monomethylfumarate influences multiple parameters consistent with improved retinal health in SCD and may therefore be of therapeutic potential in SR treatment. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

Motivations Behind Sustainable Purchasing

OpenAIRE

Vörösmarty, Gyöngyi; Dobos, Imre; Tátrai, Tünde

2011-01-01

Sustainability issues in purchasing are receiving greater attention. Literature is rapidly growing, with several research programs being initiated to investigate the topic. This study presents the results of a research project which aims to reveal and structure the motivating forces leading companies to make efforts in sustainability purchasing and the means used to attain achievements in some fields of sustainability. Results presented in the literature are scattered in terms of ...

Annual Sustainability Report FY 2014. Incorporates NREL Site Sustainability Plan

Energy Technology Data Exchange (ETDEWEB)

Rukavina, Frank [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2015-07-01

NREL's Sustainability Program is responsible for upholding all executive orders, federal regulations, U.S. Department of Energy (DOE) orders, and goals related to sustainable and resilient facility operations. But NREL continues to expand sustainable practices above and beyond the laboratory's regulations and requirements to ensure that the laboratory fulfills its mission into the future, leaves the smallest possible legacy footprint, and models sustainable operations and behaviors on national, regional, and local levels. The report, per the GRI reporting format, elaborates on multi-year goals relative to executive orders, achievements, and challenges; and success stories provide specific examples. A section called 'Sustaining NREL's Future Through Integration' provides insight into how NREL is successfully expanding the adoption of renewable energy technologies through integration.

Sustainable urban transport indicators: tool for evaluating transport sustainability in the mega cities of Pakistan

International Nuclear Information System (INIS)

Imran, M.

2005-01-01

Urban Transport is an important sector to accomplish the goal of sustainable development in Pakistan. This is important because of the high growth of the transport sector's energy consumption, road crashes and greenhouse gas emissions. This becomes significant in the Pakistani cities where motor vehicle fleet is growing at two to three times the rate of population. Transport Policies has resulted high growth of urban road traffic, increasing air and noise pollution throughout the country. This situation raised the question how to achieve sustainable urban transport in the mega cities of Pakistan? Development of sustainable urban transport indicators will provide an opportunity to analyze current transport policies to assess Pakistan progress towards or away from sustainability. Medium Term Development Framework (2005-10) has selected to analyze against establish sustainable urban transport indicators for Pakistan. On the basis of analysis, it has found that MWF has tried to address transport problem in a piecemeal manner, rather than adopting a holistic approach. Implementing MTDF policies on transport is not fully matched with a long term commitment to achieving sustainable development in Pakistan. (author)

Sustainable development and construction industry in Malaysia

Directory of Open Access Journals (Sweden)

Suliman L. Kh. M.

2009-12-01

Full Text Available Sustainable construction is a way for the building and infrastructure industry to move towards achieving sustainable development, taking into account environmental, socioeconomic and cultural issues. Differing approaches and differing economic markets lead to different priorities. This paper presents the construction scenario of Malaysia and the developments in sustainable construction taking place in this country. Barriers to the implementation of sustainable construction are discussed. A list of recommendation was proposed to drive sustainable construction in this country. In conclusion, the status of sustainable construction in Malaysia is still in its infancy. The lack of awareness, training and education, ineffective procurement systems, existing public policies and regulatory frameworks are among the major barriers for sustainable construction in Malaysia. Besides the needs for capacities, technologies and tools, total and ardent commitment by all players in the construction sectors including the governments and the public atlarge are required in order to achieve sustainable construction in Malaysia.

A New Agenda for Sustainability

DEFF Research Database (Denmark)

Aagaard Nielsen, Kurt

Two decades after the Brundtland Commission's Report "Our Common Future" adopted the concept of 'sustainable development', this book provides a renewal of the concept exploring the potential for new practices and fields for those involved in sustainability activity. The book addresses a number...... on sustainability. The material dealt with in the book offers a wide variety of perspectives on sustainability and reflects the importance of interdisciplinary and transdiciplinary work in the field. Suggesting targets for future analytical and political efforts in achieving global sustainability, this book offers...

From Corporate Social Responsibility to Corporate Sustainability: Features of Financing Sustainable Development

Directory of Open Access Journals (Sweden)

Vasylchuk Irуna P.

2018-03-01

Full Text Available The theoretical basis of the concepts of corporate social responsibility and sustainable development are studied. It is revealed that scientists mainly distinguish two main stages in the evolution of the concept of corporate social responsibility. There argued the expediency of singling out the third stage of the development of the concept (version CSR 2.0, which is characterized by the integration of the theoretical and practical foundations of the concepts of CSR and sustainable development as well as by their implementation into activities of corporations. The presence of the necessary prerequisites for singling out the new stage in the evolution of these concepts (version CSR 3.0, which is based on the provisions of the collaborative theory and provides for the cooperation of social enterprises and sustainable corporations in achieving the goals of sustainable development, is revealed, its expediency is justified. The determinant of the stage is the use of opportunities for sustainable development, the dominant is the social orientation, and its content is characterized by the slogan “doing common good to do common well”. Using generalization, there identified the features of the established models of sustainable development of corporations by key aspects (goals, principles, methods. On this basis, the features of approaches to financing sustainable development at the macro and micro levels are determined, and the principles for financing the activities of corporations in the new conditions are defined. It is concluded that achieving sustainability requires an effective system of financing corporate measures aimed at sustainable development, for the creation of which in Ukraine it is necessary to use the experience of “best practices” at the national, local and corporate levels.

SUSTAINABLE URBAN COMMUNITY DEVELOPMENT THROUGH AGENDA 21

Directory of Open Access Journals (Sweden)

Zainal Md Zan

2015-08-01

Full Text Available The much-talked about issues such as the rising of heavy crime cases, problems in solid waste management, air and water pollution as well as traffic congestion detering the quality of life among urban community members. Urgent and proactive measure is highly desireable in order to preserve and maintain the integral parts of urban’s higher quality of life. All parties should take part in ongoing efforts to achieve sustainable development through various means. Local Agenda 21 (LA21 serves as one of the efforts in achieveing the ultimate goal of sustainable development through better collaboration and cooperation among stakeholders including local government, non-governmental organisations and the community at large. The core principle of the LA21 program lies in the spirit of cooperation among community members, local authorities and the private sectors. This could be achieved through various activities including from the beginning such as through a comprehensive planning for the local area to achieve the sustainable development. Community members should be involved in brainstorming of the ideas and expressing their views so that authorities would be able to identify the real and arising issues in the community. Through this way a sustainable town and municipal planning could be developed and initiated. This paper discusses the importance of urbancommunity participation in achieving sustainable development as practicedthrough LA21 in Seberang Perai Municipal Council, Penang.

Finding pathways to national-scale land-sector sustainability

Science.gov (United States)

Gao, Lei; Bryan, Brett A.

2017-04-01

The 17 Sustainable Development Goals (SDGs) and 169 targets under Agenda 2030 of the United Nations map a coherent global sustainability ambition at a level of detail general enough to garner consensus amongst nations. However, achieving the global agenda will depend heavily on successful national-scale implementation, which requires the development of effective science-driven targets tailored to specific national contexts and supported by strong national governance. Here we assess the feasibility of achieving multiple SDG targets at the national scale for the Australian land-sector. We scaled targets to three levels of ambition and two timeframes, then quantitatively explored the option space for target achievement under 648 plausible future environmental, socio-economic, technological and policy pathways using the Land-Use Trade-Offs (LUTO) integrated land systems model. We show that target achievement is very sensitive to global efforts to abate emissions, domestic land-use policy, productivity growth rate, and land-use change adoption behaviour and capacity constraints. Weaker target-setting ambition resulted in higher achievement but poorer sustainability outcomes. Accelerating land-use dynamics after 2030 changed the targets achieved by 2050, warranting a longer-term view and greater flexibility in sustainability implementation. Simultaneous achievement of multiple targets is rare owing to the complexity of sustainability target implementation and the pervasive trade-offs in resource-constrained land systems. Given that hard choices are needed, the land-sector must first address the essential food/fibre production, biodiversity and land degradation components of sustainability via specific policy pathways. It may also contribute to emissions abatement, water and energy targets by capitalizing on co-benefits. However, achieving targets relevant to the land-sector will also require substantial contributions from other sectors such as clean energy, food systems

Grazing animal husbandry based on sustainable nutrient management

NARCIS (Netherlands)

Hermans, C.; Vereijken, P.H.

1995-01-01

Sustainable husbandry systems for grazing animals (cattle and sheep) can be achieved by sustainable nutrient management (SNM). This implies the tuning of inputs to outputs of nutrients, to achieve and maintain optimum ranges of agronomically wanted and ecologically acceptable reserves of single

Handbook of sustainable engineering

CERN Document Server

Lee, Kun-Mo

2013-01-01

"The efficient utilization of energy, sustainable use of natural resources, and large-scale adoption of sustainable technologies is the key to a sustainable future. The Handbook of Sustainable Engineering provides tools that will help us achieve these goals". Nobel Prize Winner Dr. R.K. Pauchauri, Chairman, UN Intergovernmental Panel on Climate Change As global society confronts the challenges of diminishing resources, ecological degradation, and climate change, engineers play a crucial role designing and building technologies and products that fulfil our needs for utility and sustainability. The Handbook of Sustainable Engineering equips readers with the context and the best practices derived from both academic research and practical examples of successful implementations of sustainable technical solutions. The handbook’s content revolves around the two themes, new ways of thinking and new business models, including sustainable production, products, service systems and consumption while addressing key asse...

Catalysis and sustainable (green) chemistry

Energy Technology Data Exchange (ETDEWEB)

Centi, Gabriele; Perathoner, Siglinda [Dipartimento di Chimica Industriale ed Ingegneria dei Materiali, University of Messina, Salita Sperone 31, 98166 Messina (Italy)

2003-01-15

Catalysis is a key technology to achieve the objectives of sustainable (green) chemistry. After introducing the concepts of sustainable (green) chemistry and a brief assessment of new sustainable chemical technologies, the relationship between catalysis and sustainable (green) chemistry is discussed and illustrated via an analysis of some selected and relevant examples. Emphasis is also given to the concept of catalytic technologies for scaling-down chemical processes, in order to develop sustainable production processes which reduce the impact on the environment to an acceptable level that allows self-depuration processes of the living environment.

European Food and Drink Wholesalers and Sustainability

Directory of Open Access Journals (Sweden)

Peter Jones

2017-01-01

Full Text Available Purpose- The aim of this paper is to review and reflect on the sustainability agendas and achievements reported by Europe's leading food and drinks wholesalers. Design/Methodology/Approach- The paper begins with a short introduction to corporate sustainability, sustainability reporting and food and drinks wholesaling within Europe and the empirical material for the paper is drawn from reports and information posted on the leading food and drinks wholesalers' corporate websites. Findings- There are marked variations in the extent to which Europe's leading food and drinks wholesalers reported and provided information on their sustainability agendas and achievements. These agendas and achievements embraced a wide range of environmental, social and economic issues but the reporting process had a number of weaknesses that undermine its transparency and credibility. The authors also argue that the leading food and drinks wholesalers' definitions of, and commitments to, sustainability are principally driven by business imperatives as by any fundamental concern to maintain the viability and integrity of natural and social capital. More critically the authors argue that this approach is couched within existing business models centred on continuing growth and consumption Limitations- The paper is a preliminary review of the sustainability agendas and achievements publicly reported by Europe's leading food and drinks wholesalers. Originality- The role of Europe's wholesale sector in addressing sustainability has received scant attention in the academic literature and this paper will interest academics and students in business management and marketing and employees and executives working in the distribution sector of the economy.

Desired, Perceived, and Achieved Sustainability: Trade-Offs in Strategic and Operational Packaging Development

Directory of Open Access Journals (Sweden)

Bjorn de Koeijer

2017-10-01

Full Text Available The alignment of the strategic and the operational level of packaging development in relation to the integration of sustainability is not addressed extensively in current research. This paper aims to address this, by focusing on the decision-making interrelations of key actors (marketing and packaging development within multidisciplinary product-packaging development teams. The research is conducted by means of a qualitative approach, consisting of semi-structured interviews with individual packaging development team members, complemented with a newly developed visualization tool. The research builds upon eight cases within brand owners, packaging material suppliers and packaging development consultants. The main findings of the study include the decision-making trade-offs between sustainability considerations and other project indicators, such as costs, time-to-market and technical challenges. These trade-offs are linked to the strategic and operational roles of key actors, and to internal and external factors influencing sustainable development processes. This research’s contribution is to address the alignment of the strategic and the operational levels of sustainable packaging development, in relation to (1 decision making and interrelations within multidisciplinary development teams; and (2 the relevance of development-influencing factors. This provides opportunities for further development of sustainable packaging models and tools, in order to align the strategic and operational level of development.

The review of the achieved degree of sustainable development in South Eastern Europe - The use of linear regression method

Energy Technology Data Exchange (ETDEWEB)

Golusin, Mirjana [Educons University, Vojvode Putnika st. bb, 21013 Sremska Kamnica (RS); Ivanovic, Olja Munitlak [Faculty of Business in Services, Vojvode Putnik st. bb, 21013 Sremska Kamenica (RS); Teodorovic, Natasa [Faculty of Entrepreneurial Management, Modene st. 5, 21000 Novi Sad (RS)

2011-01-15

The need for preservation and adequate management of the quality of environment requires the development of new methods and techniques by which the achieved degree of sustainable development can be defined as well as the laws regarding the relationship among its subsystems. Main objective of research is to point to a strong contradiction between the development of ecological and economic subsystems. In order to improve previous research, this study suggests the use of linear evaluation, by which it is possible to determine the exact degree of contradiction between these two subsystems and to define the regularities as well as the deviations. Authors present the essential steps that were used. Conducted by the method of linear regression this research shows a significant negative correlation between ecological and economic subsystem indicators, whereas its value R{sup 2} 0.58 proves the expected contradiction that exists between the two previously mentioned subsystems. By observing the sustainable development as a two-dimensional system that includes ecological and economic indicators, the authors suggest the methodology to modelling the relationship between economic and ecological development as an orthogonal distance between the degree of the current state measured by the relation between economic and ecological indicators of sustainable development and the degree which was obtained in a traditional way. The method used in this research proved to be extremely suitable for modelling the relationship between ecological and economic subsystems of sustainable development. This research was conducted on a repeated sample of countries of South East Europe by including the data for France and Germany, being two countries on the highest level of development in the European Union. (author)

Sustainable agriculture in the picture

International Nuclear Information System (INIS)

Brouwer, F.M.; De Bont, C.J.A.M.; Leneman, H.; Van der Meulen, H.A.B.

2004-01-01

Sustainable agriculture in the picture provides a systematic overview of the available data that are relevant for debate on transitions towards sustainable agriculture. Review for the agrocomplex, greenhouse horticulture, dairy farming and pig farming. Indicators on economy, environment, nature, animal welfare, human and animal health. Results achieved in practice for the three dimensions of sustainable agriculture, namely economics ('profit'), ecology ('planet') and socio-cultural ('people') [nl

Organizational Learning and Sustainable Competitive Advantages (SCA): The Nigerian Experience

OpenAIRE

Omotayo Oyeniyi

2011-01-01

The purpose of this paper is to test for core competencies of organizations in achieving sustainable competitive advantage within the service organizations in a developing economy like Nigeria. The paper specifically deals with the importance of organizational learning on sustainable competitive advantage and how it can be used to achieve sustainable advantage. Despite the wide spread importance attached to building sustainable competitive advantage, the relationship between organizational le...

Winning the sustainable development debate

International Nuclear Information System (INIS)

Ritch, John; Cornish, Emma

2002-01-01

Full text: This year - in Johannesburg from 26 August to 4 September - the world will witness what is expected to be the largest environmental gathering yet: the World Summit on Sustainable Development. Some 60,000 participants, including Heads of State, government officials, intergovernmental organizations, and environmental, business and scientific lobbies, will debate the world's progress in implementing 'Agenda 2 V - the sustainable development principles agreed in Rio de Janeiro in 1992. Some kind of deal, perhaps in the form of a declaration, will emerge from Johannesburg, reasserting international commitment to sustainable development. At this stage the content cannot be predicted. Experience warns us to expect a strong and virulent anti-nuclear lobby, not only as part of the 'environmental community', but within some of the governments themselves. Their role will be to achieve a text declaring nuclear an unsustainable energy source. The nuclear industry has six months to make its case, in the preparatory fora and elsewhere, that nuclear energy must be recognized - and at a minimum, not excluded - as a sustainable development technology. Twin goals of sustainable development: meeting human need and achieving environmental security. The principle of sustainable development aims at the long-term environmental protection of the planet - sparing our children and their children from living on a planet irredeemably spoilt through human action. An equally pressing issue is that of bridging the wealth gap between the North and South. In this vein, UN Secretary General Kofi Annan recently published his priorities for attention at the World Summit. These include: - Poverty eradication and achieving sustainable livelihoods; - Promoting health through sustainable development; - Access to energy and energy efficiency; - Managing the world's freshwater resources; - Sustainable development initiatives for Africa. The central element of sustainable development: clean energy

Sustainability in Fashion Business Operations

Directory of Open Access Journals (Sweden)

Tsan-Ming Choi

2015-11-01

Full Text Available Under the global trend of sustainability, many companies selling fashion products have to reshape their operational strategies. Over the past few years, we have witnessed many fashion companies going green by re-engineering their business processes and establishing their formal sustainability programs. Many important topics, such as closed-loop supply chain management, corporate social responsibility, and economic sustainability, are all related to sustainable fashion business operations management. This paper provides a brief review of these critical topics, introduces the special issue, and proposes future research areas to achieve sustainable operations management in the fashion business.

Positive and Negative Impacts of Oil Palm Expansion in Indonesia and the Prospect to Achieve Sustainable Palm Oil

Science.gov (United States)

Shahputra, M. A.; Zen, Z.

2018-02-01

The aim of the study is to deepen understanding the role of palm oil on Indonesian economy, poverty elevation and to investigate the positive and negative impacts of oil palm expansion, due to the burden of GHG emissions; and prospect to be more sustainable palm oil industry. The statistics show that average rural poverty tends to be lower and Gross Regional Product tends to be higher in provinces which have greater levels of oil palm cultivation. Indonesian oil palm will grow from 10.6 in 2013 to 13.7 million ha by 2020. This will release 135.59 million tons of CO2 if nothing is done to mitigate BAU emissions. Unless there are sustained efforts to redirect development and expansion of oil palm, plantation growth will continue to encroach on intact forest and peat land.. In fact Indonesia has large areas of degraded land, an estimated total 19,144,000 ha is available for planting oil palm and other crops. A large-scale expansion program driven by estate companies needs to be accompanied by effective smallholder development program in order to achieve the best outcome for local farmers and avoid the conflicts.

Achieving and sustaining profound institutional change in healthcare: case study using neo-institutional theory.

Science.gov (United States)

Macfarlane, Fraser; Barton-Sweeney, Cathy; Woodard, Fran; Greenhalgh, Trisha

2013-03-01

Change efforts in healthcare sometimes have an ambitious, whole-system remit and seek to achieve fundamental changes in norms and organisational culture rather than (or as well as) restructuring the service. Long-term evaluation of such initiatives is rarely undertaken. We report a secondary analysis of data from an evaluation of a profound institutional change effort in London, England, using a mixed-method longitudinal case study design. The service had received £15 million modernisation funding in 2004, covering multiple organisations and sectors and overseen by a bespoke management and governance infrastructure that was dismantled in 2008. In 2010-11, we gathered data (activity statistics, documents, interviews, questionnaires, site visits) and compared these with data from 2003 to 2008. Data analysis was informed by neo-institutional theory, which considers organisational change as resulting from the material-resource environment and three 'institutional pillars' (regulative, normative and cultural-cognitive), enacted and reproduced via the identities, values and activities of human actors. Explaining the long-term fortunes of the different components of the original programme and their continuing adaptation to a changing context required attention to all three of Scott's pillars and to the interplay between macro institutional structures and embedded human agency. The paper illustrates how neo-institutional theory (which is typically used by academics to theorise macro-level changes in institutional structures over time) can also be applied at a more meso level to inform an empirical analysis of how healthcare organisations achieve change and what helps or hinders efforts to sustain those changes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Achieving and sustaining automated health data linkages for learning systems: barriers and solutions.

Science.gov (United States)

Van Eaton, Erik G; Devlin, Allison B; Devine, Emily Beth; Flum, David R; Tarczy-Hornoch, Peter

2014-01-01

implementations required each hospital to devote more IT resources than were predicted. Cost savings did not meet projections because of the increased IT resource requirements and a different source of lowered chart review costs. CERTAIN succeeded in recruiting unaffiliated hospitals into the Automation Project to create an enhanced registry to achieve AHRQ goals. This case report describes several distinct barriers to central data aggregation for QI and CER across unaffiliated hospitals: (1) competition for limited on-site IT expertise, (2) concerns about data use for QI versus research, (3) restrictions on data automation to a defined subset of patients, and (4) unpredictable resource needs because of idiosyncrasies among unaffiliated hospitals in how EHR data are coded, stored, and made available for transmission-even between hospitals using the same vendor's EHR. Therefore, even a fully optimized automation infrastructure would still not achieve complete automation. The Automation Project was unable to align sufficiently with internal hospital objectives, so it could not show a compelling case for sustainability.

Sign Language Legislation as a Tool for Sustainability

Science.gov (United States)

Pabsch, Annika

2017-01-01

This article explores three models of sustainability (environmental, economic, and social) and identifies characteristics of a sustainable community necessary to sustain the Deaf community as a whole. It is argued that sign language legislation is a valuable tool for achieving sustainability for the generations to come.

DUV light source sustainability achievements and next steps

Science.gov (United States)

Roman, Yzzer; Cacouris, Ted; Raju, Kumar Raja Guvindan; Kanawade, Dinesh; Gillespie, Walt; Luo, Siqi; Mason, Eric; Manley, David; Das, Saptaparna

2018-03-01

Key sustainability opportunities have been executed in support of corporate initiatives to reduce the environmental footprint and decrease the running cost of DUV light sources. Previously, substantial neon savings were demonstrated over several years through optimized gas management technologies. Beyond this work, Cymer is developing the XLGR 100, a self-contained neon recycling system, to enable minimal gas consumption. The high efficiency results of the XLGR 100 in a production factory are validated in this paper. Cymer has also developed new light source modules with 33% longer life in an effort to reduce raw and associated resource consumption. In addition, a progress report is included regarding the improvements developed to reduce light source energy consumption.

Sustaining College Students' Persistence and Achievement through Exemplary Instructional Strategies

Science.gov (United States)

Gentry, Ruben

2014-01-01

A "take it or leave it" attitude has no place in higher education. Society needs an educated citizenry to sustain and advance its technological and global mission. Too few students are entering college and even fewer than might reasonably be expected are graduating. Retention and graduation rates serve as key indicators of performance…

Achieving Energy Efficiency Through Real-Time Feedback

Energy Technology Data Exchange (ETDEWEB)

Nesse, Ronald J.

2011-09-01

Through the careful implementation of simple behavior change measures, opportunities exist to achieve strategic gains, including greater operational efficiencies, energy cost savings, greater tenant health and ensuing productivity and an improved brand value through sustainability messaging and achievement.

ACHIEVING SUSTAINABLE TOURISM THROUGH CUSTOMER SATISFACTION

Directory of Open Access Journals (Sweden)

Ispas Roxana

2012-12-01

Full Text Available In tourism, hotels play an important role and contribute to the economic growth in cities and other places endowed with attractions which are universally recognized. Two elements are essential in the tourism industry system: product quality and human resources. In terms of quality of the hotel services, that is the one that allows to the tourist enterprise to own a competitive advantage, gain competitive differentiation and reputation among customers by achieving a high degree of customer satisfaction. Hotel customer satisfaction would be impossible if the hotel management does not perform periodic evaluations on customer satisfaction and quality, which are the focus of this paper. Therefore, this paper focuses on customer satisfaction measured by the SERVQUAL model.

Hydroxyurea inhibits parvovirus B19 replication in erythroid progenitor cells.

Science.gov (United States)

Bonvicini, Francesca; Bua, Gloria; Conti, Ilaria; Manaresi, Elisabetta; Gallinella, Giorgio

2017-07-15

Parvovirus B19 (B19V) infection is restricted to erythroid progenitor cells (EPCs) of the human bone marrow, leading to transient arrest of erythropoiesis and severe complications mainly in subjects with underlying hematological disorders or with immune system deficits. Currently, there are no specific antiviral drugs for B19V treatment, but identification of compounds inhibiting B19V replication can be pursued by a drug repositioning strategy. In this frame, the present study investigates the activity of hydroxyurea (HU), the only disease-modifying therapy approved for sickle cell disease (SCD), towards B19V replication in the two relevant cellular systems, the UT7/EpoS1 cell line and EPCs. Results demonstrate that HU inhibits B19V replication with EC 50 values of 96.2µM and 147.1µM in UT7/EpoS1 and EPCs, respectively, providing experimental evidence of the antiviral activity of HU towards B19V replication, and confirming the efficacy of a drug discovery process by drug repositioning strategy. The antiviral activity occurs in vitro at concentrations lower than those affecting cellular DNA replication and viability, and at levels measured in plasma samples of SCD patients undergoing HU therapy. HU might determine a dual beneficial effect on SCD patients, not only for the treatment of the disease but also towards a virus responsible for severe complications. Copyright © 2017 Elsevier Inc. All rights reserved.

Sustainable built environments

CERN Document Server

Haase, Dagmar

2013-01-01

Sustainable design is a collective process whereby the built environment achieves unprecedented levels of ecological balance through new and retrofit construction, with the goal of long-term viability and humanization of architecture. Focusing on the environmental context, sustainable design merges the natural, minimum resource conditioning solutions of the past (daylight, solar heat, and natural ventilation) with the innovative technologies of the present.  The desired result is an integrated “intelligent” system that supports individual control with expert negotiation for resource consciousness. International experts in the field address the fundamental questions of sustainable design and landscape management: How should the sustainability of landscapes and buildings be evaluated? Which targets have to be set and which thresholds should not be exceeded? What forms of planning and governance structures exist and to what extent do they further the goals of sustainability?  Gathering 30 peer-reviewed ent...

Achieving resource sustainability and enhancing economic development through biomass utilization

Science.gov (United States)

Jerrold E. Winandy

2005-01-01

As the problems associated with sustaining and enhancing the world's forest and agricultural resources compete with the needs of a rapidly increasing and affluent population, the management of our land becomes a much more complex and important issue. One of the most important environmental features of wood and other woody-like fibers is that they are renewable and...

Promoting sustainability through green chemistry

Energy Technology Data Exchange (ETDEWEB)

Kirchhoff, Mary M. [American Chemical Society, 1155 Sixteenth Street, NW, Washington, DC 20036 (United States)

2005-06-15

Green chemistry is an important tool in achieving sustainability. The implementation of green chemistry, the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances, is essential if the expanding global population is to enjoy an increased standard of living without having a negative impact on the health of the planet. Cleaner technologies will allow the chemical enterprise to provide society with the goods and services on which it depends in an environmentally responsible manner. Green chemistry provides solutions to such global challenges as climate change, sustainable agriculture, energy, toxics in the environment, and the depletion of natural resources. A collaborative effort by industry, academia, and government is needed to promote the adoption of the green chemistry technologies necessary to achieve a sustainable society.

Seaports as turntables for sustainability. Policy memo Sustainable Seaports

International Nuclear Information System (INIS)

Lammers, J.

2008-11-01

Dutch seaports are expected to operate at top level worldwide with regard to their quality of service. Sustainable development of the seaports is an essential prerequisite to achieve this. Therefore the Dutch government will cooperate with decentralized authorities, port managers, enterprises linked to the Dutch ports, knowledge institutes and societal groups to increase the sustainability of the Dutch seaports. The following five themes are focuses upon in this effort: air quality; energy, CO2 and residual flows; spatial use; environmental conservation and development; water quality and management. [mk] [nl

Universal health coverage and the health Sustainable Development Goal: achievements and challenges for Sri Lanka.

Science.gov (United States)

de Silva, Amala; Ranasinghe, Thushara; Abeykoon, Palitha

2016-09-01

With state-funded health care that is free at the point of delivery, a sound primary health-care policy and widespread health-care services, Sri Lanka seems a good example of universal health coverage. Yet, health transition and disparities in provision and financing threaten this situation. Sri Lanka did well on the Millennium Development Goal health indicators, but the Sustainable Development Goal (SDG) for health has a wider purview, which is to "ensure healthy lives and promote well-being for all at all ages". The gender gap in life expectancy and the gap between life expectancy and healthy life expectancy make achievement of the health SDG more challenging. Although women and children do well overall, the comparative health disadvantage for men in Sri Lanka is a cause for concern. From a financing perspective, high out-of-pocket expenditure and high utilization of the private sector, even by those in the lowest income quintile, are concerns, as is the emerging "third tier", where some individuals accessing state health care that is free at the point of delivery actually bear some of the costs of drugs, investigations and surgery. This cost sharing is resulting in catastrophic health expenditure for individuals, and delays in and non-compliance with treatment. These concerns about provision and financing must be addressed, as health transition will intensify the morbidity burden and loss of well-being, and could derail plans to achieve the health SDG.

Sustainable Building Operation

DEFF Research Database (Denmark)

Jensen, Jesper Ole

2009-01-01

of sustainable building operation and a survey amongst building administrators from the private and the social housing sector. Our results show that there are many good examples on sustainable building operation in Danish housing estates, where local building managers, residents etc. have gained impressive......Energy-savings in the existing building stock have becomes a main goal in national and international policies. Often focus is on building-renovations, whereas the potential of sustainable building operation to a large extent has been neglected. Nevertheless, international research as well...... as practical experiences from Danish housing estates indicates that there are large potentials for energy savings by focusing on the operation of the buildings. We suggest that in order to achieve sustainability in the existing housing, renovation and operations should be seen as integrated parts...

An Understanding of Sustainability and Education for Sustainable Development among German Student Teachers and Trainee Teachers of Chemistry

Science.gov (United States)

Burmeister, Mareike; Eilks, Ingo

2013-01-01

Sustainable development is a central concern of today's politics across the world. Different political agendas have been developed to promote sustainability and make it a political goal worldwide. As stated in Agenda 21, the political debate seems to agree that education has to play a key role in achieving sustainability. But practices focusing on…

Neighborhood Sustainability Assessment: Evaluating Residential Development Sustainability in a Developing Country Context

Directory of Open Access Journals (Sweden)

Tan Yigitcanlar

2015-03-01

Full Text Available Rapid urbanization, improved quality of life, and diversified lifestyle options have collectively led to an escalation in housing demand in our cities, where residential areas, as the largest portion of urban land use type, play a critical role in the formation of sustainable cities. To date there has been limited research to ascertain residential development layouts that provide a more sustainable urban outcome. This paper aims to evaluate and compare sustainability levels of residential types by focusing on their layouts. The paper scrutinizes three different development types in a developing country context—i.e., subdivision, piecemeal, and master-planned developments. This study develops a “Neighborhood Sustainability Assessment” tool and applies it to compare their sustainability levels in Ipoh, Malaysia. The analysis finds that the master-planned development, amongst the investigated case studies, possesses the potential to produce higher levels of sustainability outcomes. The results reveal insights and evidence for policymakers, planners, development agencies and researchers; advocate further studies on neighborhood-level sustainability analysis, and; emphasize the need for collective efforts and an effective process in achieving neighborhood sustainability and sustainable city formation.

Sustainable Process Synthesis-Intensification

DEFF Research Database (Denmark)

Babi, Deenesh Kavi; Holtbruegge, Johannes; Lutze, Philip

2014-01-01

Sustainable process design can be achieved by performing process synthesis and process intensification together. This approach first defines a design target through a sustainability analysis and then finds design alternatives that match the target through process intensification. A systematic......, multi-stage framework for process synthesis- intensification that identifies more sustainable process designs has been developed. At stages 1-2, the working scale is at the level of unit operations, where a base case design is identified and analyzed with respect to sustainability metrics. At stages 3......, a phenomena-based process synthesis method is applied, where the phenomena involved in each tasks are identified, manipulated and recombined to generate new and/or existing unit operations configured into flowsheets that are more sustainable from those found in the previous levels. An overview of the key...

How to Achieve Supply Chain Sustainability Efficiently? Taming the Triple Bottom Line Split Business Cycle

Directory of Open Access Journals (Sweden)

Matthias Klumpp

2018-02-01

Full Text Available For sustainable supply chains, specific concepts regarding how to efficiently improve sustainability are needed in a global comprehensive triple bottom line (TBL approach, especially for forwarders as central actors in supply chain design. Such specific advice is provided by reporting empirical DEA Malmquist index findings from seven large European forwarders regarding a TBL sustainability analysis from 2006 to 2016. A major obstacle in improving sustainability consists in the newly discovered fact that with the business cycle, the three TBL areas of economic, ecologic and social objectives for logistics are undergoing different up- and down-ward trends, making it very hard to improve all three simultaneously. Additional factors are identified in the characteristics of size and government influence regarding the sustainability efficiency of forwarders. This has important impacts on supply chain design like e.g., with selection criteria.

Progress in sustainable energy technologies

CERN Document Server

Dincer, Ibrahim; Kucuk, Haydar

2014-01-01

This multi-disciplinary volume presents information on the state-of-the-art in sustainable energy technologies key to tackling the world's energy challenges and achieving environmentally benign solutions. Its unique amalgamation of the latest technical information, research findings and examples of successfully applied new developments in the area of sustainable energy will be of keen interest to engineers, students, practitioners, scientists and researchers working with sustainable energy technologies. Problem statements, projections, new concepts, models, experiments, measurements and simula

Corporate Sustainability Management and Environmental Ethics

DEFF Research Database (Denmark)

Schuler, Douglas; Rasche, Andreas; Etzion, Dror

2017-01-01

This article reviews four key orientations in environmental ethics that range from an instrumental understanding of sustainability to one that acknowledges the intrinsic value of sustainable behavior (i.e., sustainable resource use, conservation and preservation, rights-based perspectives, and deep...... ecology). It then shows that the current scholarly discourse around corporate sustainability management—as reflected in environment management (EM), corporate social responsibility (CSR), and corporate political activity (CPA)—mostly favors an instrumental perspective on sustainability. Sustainable...... business practices are viewed as anthropocentric and are conceptualized as a means to achieve competitive advantage. Based on these observations, we speculate about what corporate sustainability management might look like if it applied ethical orientations that emphasize the intrinsic value of nature...

Conceptualising sustainability assessment

International Nuclear Information System (INIS)

Pope, Jenny; Annandale, David; Morrison-Saunders, Angus

2004-01-01

Sustainability assessment is being increasingly viewed as an important tool to aid in the shift towards sustainability. However, this is a new and evolving concept and there remain very few examples of effective sustainability assessment processes implemented anywhere in the world. Sustainability assessment is often described as a process by which the implications of an initiative on sustainability are evaluated, where the initiative can be a proposed or existing policy, plan, programme, project, piece of legislation, or a current practice or activity. However, this generic definition covers a broad range of different processes, many of which have been described in the literature as 'sustainability assessment'. This article seeks to provide some clarification by reflecting on the different approaches described in the literature as being forms of sustainability assessment, and evaluating them in terms of their potential contributions to sustainability. Many of these are actually examples of 'integrated assessment', derived from environmental impact assessment (EIA) and strategic environmental assessment (SEA), but which have been extended to incorporate social and economic considerations as well as environmental ones, reflecting a 'triple bottom line' (TBL) approach to sustainability. These integrated assessment processes typically either seek to minimise 'unsustainability', or to achieve TBL objectives. Both aims may, or may not, result in sustainable practice. We present an alternative conception of sustainability assessment, with the more ambitious aim of seeking to determine whether or not an initiative is actually sustainable. We term such processes 'assessment for sustainability'. 'Assessment for sustainability' firstly requires that the concept of sustainability be well-defined. The article compares TBL approaches and principles-based approaches to developing such sustainability criteria, concluding that the latter are more appropriate, since they avoid many

Mapping synergies and trade-offs between energy and the Sustainable Development Goals

Science.gov (United States)

Fuso Nerini, Francesco; Tomei, Julia; To, Long Seng; Bisaga, Iwona; Parikh, Priti; Black, Mairi; Borrion, Aiduan; Spataru, Catalina; Castán Broto, Vanesa; Anandarajah, Gabrial; Milligan, Ben; Mulugetta, Yacob

2018-01-01

The 2030 Agenda for Sustainable Development—including 17 interconnected Sustainable Development Goals (SDGs) and 169 targets—is a global plan of action for people, planet and prosperity. SDG7 calls for action to ensure access to affordable, reliable, sustainable and modern energy for all. Here we characterize synergies and trade-offs between efforts to achieve SDG7 and delivery of the 2030 Agenda as a whole. We identify 113 targets requiring actions to change energy systems, and published evidence of relationships between 143 targets (143 synergies, 65 trade-offs) and efforts to achieve SDG7. Synergies and trade-offs exist in three key domains, where decisions about SDG7 affect humanity's ability to: realize aspirations of greater welfare and well-being; build physical and social infrastructures for sustainable development; and achieve sustainable management of the natural environment. There is an urgent need to better organize, connect and extend this evidence, to help all actors work together to achieve sustainable development.

Analyzing Sustainable Competitive Advantage: Strategically Managing Resource Allocations to Achieve Operational Competitiveness

Directory of Open Access Journals (Sweden)

Abdul Malek Nurul Aida

2015-12-01

Full Text Available In today’s dynamic business environment, a key challenge for all companies is to make adaptive adjustments to their manufacturing strategy. This study demonstrates the competitive priorities of manufacturing strategy in hydro-power case company to evaluate the level of sustainable competitive advantage and also to further analyze how business strategies are aligned with manufacturing strategies. This research is based on new holistic analytical evaluation of manufacturing strategy index, sense and respond, and sustainable competitive advantage models. These models help to describe, evaluate, and optimize resource allocation to meet the performance requirements in dynamic decision making. Furthermore, these models evaluate operational competitiveness for manufacturing strategies according to the multi-criteria priority. The results show that the adjustments of competitive priorities in manufacturing strategies by implementing the proposed holistic analytical models are helpful in strategically managing business operations. The discussion derives the most critical attributes in business operations while alignment of resource allocation with competitive priorities help to strategically focus those attributes. In conclusion, we argue that resource allocation and manufacturing strategies have become the most important capabilities in a business environment where companies focus to get a sustainable competitive advantage.

Sustainable development goals and inclusive development

NARCIS (Netherlands)

Gupta, J.; Vegelin, C.

Achieving sustainable development has been hampered by trade-offs in favour of economic growth over social well-being and ecological viability, which may also affect the sustainable development goals (SDGs) adopted by the member states of the United Nations. In contrast, the concept of inclusive

Students’ Assessment of Campus Sustainability at the University of Dammam, Saudi Arabia

Directory of Open Access Journals (Sweden)

Ismaila R. Abubakar

2016-01-01

Full Text Available Higher education institutions are major drivers of change in achieving environmental sustainability both within college campuses and beyond campuses in communities at large. However, achieving campus sustainability is not possible without the involvement of students as one of the major stakeholders of a university. Based on survey of 152 students of the College of Architecture and Planning, University of Dammam, Saudi Arabia, this study explores students’ assessment of campus sustainability components: curriculum and research; campus operations; and community involvement. The results show that even though the students indicate a great deal of awareness and concern about campus environmental sustainability, they lack interest and willingness to participate in initiatives towards achieving sustainability. Apart from some sustainable landscaping and waste recycling practices, there are few sustainability initiatives in transportation and energy and water conservation on the campus. Offered courses and student projects have also been reported to have modest focus on sustainability. The article concludes by highlighting the roles of incorporating sustainability into campus operations, and training university students in promoting environmental sustainability in Saudi Arabia and the Middle East.

Education for Sustainability-Challenges and Opportunities: The Case of RCEs (Regional Centres of Expertise in Education for Sustainable Development)

Science.gov (United States)

Wade, Ros

2016-01-01

This article will focus on the challenges of leadership and management of a key initiative of the 20052014 UN Decade of Education for Sustainable Development (DESD), namely the Regional Centres of Expertise in Education for Sustainability (RCEs). It will argue that in order to achieve sustainability, there is a need to move away from outdated…

Sustainable energy for all. Technical report of task force 1 in support of the objective to achieve universal access to modern energy services by 2030

Energy Technology Data Exchange (ETDEWEB)

Birol, Fatih [International Energy Agency, Paris (France); Brew-Hammond, Abeeku [University of Science and Technology (Ghana

2012-04-15

The UN Secretary General established the Sustainable Energy for All initiative in order to guide and support efforts to achieve universal access to modern energy, rapidly increase energy efficiency, and expand the use of renewable energies. Task forces were formed involving prominent energy leaders and experts from business, government, academia and civil society worldwide. The goal of the Task Forces is to inform the implementation of the initiative by identifying challenges and opportunities for achieving its objectives. This report contains the findings of Task Force One which is dedicated to the objective of achieving universal access to modern energy services by 2030. The report shows that universal energy access can be realized by 2030 with strong, focused actions set within a coordinated framework.

Sustainable Technology and Business Innovation Framework – A Comprehensive Approach

Directory of Open Access Journals (Sweden)

Maja Levi Jakšić

2018-05-01

Full Text Available Despite of the rising awareness of the urgency in finding more efficient and effective ways to achieve sustainable development, comprehensive and consistent meaning is still elusive both in theory and practice. The aim of this paper is to create a more structured theoretical framework related to macro and micro perspectives of sustainable development, relevant also to enhancing sustainable practices. We here propose a comprehensive framework model for structuring multiple sustainability principles and practices, detected in the literature as different sustainability categories related to both macro and micro perspectives of sustainability in the economy and society. The focus is on relevant sustainability principles of technology and business innovation in relation to basic technology and business innovation models as a contribution to less investigated theoretical aspects of sustainable business development. We developed a set of related matrices indicating the relevant roles and relationships between these principles in achieving sustainable business goals related to sustainable economy dimensions. Finally, the paper shows that the proposed Related Matrices Framework fulfils the main objective set in the initial research stages, i.e. to be of both theoretical and practical relevance. As a contribution to the theory it meets the need of building a structured, integrated, comprehensive model that serves the needs of better understanding different sustainability of macro and micro categories, indicating mutual relations and influences. In a practical sense, it can be used as a tool to support the management of change in companies oriented at achieving sustainable business goals based on sustainable technology and business innovation.

Practical appraisal of sustainable development-Methodologies for sustainability measurement at settlement level

International Nuclear Information System (INIS)

Moles, Richard; Foley, Walter; Morrissey, John; O'Regan, Bernadette

2008-01-01

This paper investigates the relationships between settlement size, functionality, geographic location and sustainable development. Analysis was carried out on a sample of 79 Irish settlements, located in three regional clusters. Two methods were selected to model the level of sustainability achieved in settlements, namely, Metabolism Accounting and Modelling of Material and Energy Flows (MA) and Sustainable Development Index Modelling. MA is a systematic assessment of the flows and stocks of material within a system defined in space and time. The metabolism of most settlements is essentially linear, with resources flowing through the urban system. The objective of this research on material and energy flows was to provide information that might aid in the development of a more circular pattern of urban metabolism, vital to sustainable development. In addition to MA, a set of forty indicators were identified and developed. These target important aspects of sustainable development: transport, environmental quality, equity and quality of life issues. Sustainability indices were derived through aggregation of indicators to measure dimensions of sustainable development. Similar relationships between settlement attributes and sustainability were found following both methods, and these were subsequently integrated to provide a single measure. Analysis identified those attributes of settlements preventing, impeding or promoting progress towards sustainability

Sustainable residential districts : the residents' role in project success

NARCIS (Netherlands)

Abdalla, G.

2012-01-01

Sustainable residential districts have been realized worldwide. These districts are promoted to be efficient in the use of natural materials and sustainable energy resources. Realization of sustainable residential districts can strongly contribute to achieve environmental objectives as imposed by

Sustainable construction - the standard for all public building?

Energy Technology Data Exchange (ETDEWEB)

Handyside, R. [Richard Handyside Construction Resources (United Kingdom)

2002-01-01

This article argues for the need for foresight and planning to achieve sustainable development in the construction of public buildings. Reasons why sustainable development fails are highlighted, and the key factors that go to make a development sustainable are listed and involve the choice and layout of the site, site services, the fitting of spaces to the required purpose, the arrangement of rooms to achieve maximum use of natural light, heat and air, and the choice of construction materials and finishes. The balancing of short and long-term costs, and the use of life-cycle costs in every project are discussed.

THE CORRELATION BETWEEN SUSTAINABLE PERFORMANCE MEASURES AND ORGANIZATIONAL SUSTAINABILITY IN THE BRAZILIAN CONTEXT

Directory of Open Access Journals (Sweden)

RODRIGO GOYANNES GUSMÃO CAIADO

2016-12-01

Full Text Available Over the past few years, issues of sustainability are gaining greater prominence among organizations and their stakeholders around the world and with it the effective measurement of environmental performance has been a challenge for sustainable transition. The purpose of the article is to analyse, through the the perception of market experts and researchers, what sustainable performance measures have stronger positive correlation to achieve organizational sustainability in order to help employees in making decisions that reduce the consumption of resources and that create value throughout its chain. The research is of an exploratory and descriptive nature, with qualitative and quantitative method and has a deductive logic. It aims to help professionals and academics who want to start the measurement and continuous improvement of economic, environmental, social, governance and technical performance of their organizations. Finally, the analyzes allow direct efforts to sustainable measures considered most important, allowing the transition of the organization for sustainability.

Early-career experts essential for planetary sustainability

Science.gov (United States)

Lim, Michelle; Lynch, Abigail J.; Fernández-Llamazares, Alvaro; Balint, Lenke; Basher, Zeenatul; Chan, Ivis; Jaureguiberry, Pedro; Mohamed, A.A.A.; Mwampamba, Tuyeni H.; Palomo, Ignacio; Pliscoff, Patricio; Salimov, R.A.; Samakov, Aibek; Selomane, Odirilwe; Shrestha, Uttam B.; Sidorovich, Anna A.

2017-01-01

Early-career experts can play a fundamental role in achieving planetary sustainability by bridging generational divides and developing novel solutions to complex problems. We argue that intergenerational partnerships and interdisciplinary collaboration among early-career experts will enable emerging sustainability leaders to contribute fully to a sustainable future. We review 16 international, interdisciplinary, and sustainability-focused early-career capacity building programs. We conclude that such programs are vital to developing sustainability leaders of the future and that decision-making for sustainability is likely to be best served by strong institutional cultures that promote intergenerational learning and involvement.

Analysis on Transportation Infrastructure Availability to Achieve Environmental and Social Sustainability in Karawang

Science.gov (United States)

Rarasati, A. D.; Octoria, N. B.

2018-03-01

Sustainable infrastructure is the key to development success. At the same time, transportation infrastructure development will involve social and environmental conditions of the local surroundings. Assessment of the availability of such transport infrastructure is one of the solutions adapted from social and environmental impacts. By conducting a correlation test, the presence of transportation infrastructure and the social conditions of the environment can be identified. The results obtained show that the accessibility, the level of security, and the level of equality are correlated to social and environmental sustainability in Karawang. In terms of environment, the availability of transportation infrastructure is not directly related to the impact of environmental sustainability. The impact of the perceived environment also has no effect on the journey. Correlation results indicate that the length of travel time and congestion level do not make the perceived impact greater. The impact of the perceived environment is merely due to the high utilization of private vehicles in Karawang which subsequently leads to higher energy consumption.

Developing entrepreneurial leadership for sustainable organisations

OpenAIRE

Rae, David

2018-01-01

This chapter sets out to explore the field of leadership development and its emerging contribution to sustainable entrepreneurship; why there is a need to develop research and effective practices in this area, and how this might be achieved. It studies the questions of how organisations can generate entrepreneurial leadership for their longer-term sustainability; how they can develop a sustained culture of entrepreneurship, and how they can facilitate people into leadership roles, which enabl...

Critical Factors to Achieve Dockless Bike-Sharing Sustainability in China: A Stakeholder-Oriented Network Perspective

Directory of Open Access Journals (Sweden)

Jian-gang Shi

2018-06-01

Full Text Available In China, dockless bike-sharing programs (DBSPs play a significant role in promoting the goals of sustainable urban travel and carbon emissions reduction. However, the sustainability of DBSPs is increasingly being challenged as various issues associated with different stakeholders emerge. While numerous studies have focused on the barriers to traditional bike-sharing programs, the sustainability performance of new-generation DBSPs is largely overlooked. It is accordingly imperative to understand the primary challenges that impede the sustainability of DBSPs and to consider what stimulative measures can be taken. In this study, we investigate the factors that are critical to DBSPs’ sustainability from a network perspective. Stakeholder-associated factors and their interrelations were identified via literature analysis and interviews, and the social network analysis (SNA method was employed to recognize the critical factors and links in DBSPs. As a result, 10 critical factors and 10 major interactions were identified and further classified into six challenges. Sharing transport schemes, legislative perfection, public private partnership (PPP, and product lifecycle management (PLM were proposed to govern these challenges. This paper contributes to the existing body of knowledge of bike-sharing programs via a network approach that integrates the key influencing factors with those factors’ associated stakeholders. Furthermore, these findings provide the government and operators with implications for mitigating the tough challenges and facilitating the sustainability of DBSPs.

Sustainability and the UK’s Leading Retailers

Directory of Open Access Journals (Sweden)

Peter Jones

2015-06-01

Full Text Available This paper provides a review of the sustainability commitments and achievements currently being publicly reported by the UK’s leading retailers and of the nature of the reporting process, and also offers some reflections on the ways these retailers are addressing and pursuing sustainability agendas. The paper begins with a short discussion of the characteristics of sustainability and draws its empirical material from the most recent information on sustainability posted on the top ten UK retailer’s corporate websites. The findings reveal that the top ten UK retailers’ sustainability commitments and achievements embrace a wide range of environmental, social and economic issues but that the reporting process has a number of weaknesses that undermine its transparency and integrity. More critically, the authors argue that these commitments are principally driven by the search for efficiency gains and that they are couched within existing business models centered on continuing growth. Thus, the leading UK retailers are, at best, currently pursuing a “weak” rather than a “strong” model of sustainability; in pursuing continuing growth, they are effectively ignoring the fact the current patterns of consumption may be unsustainable in the long term. The paper provides an accessible review of the sustainability agendas being pursued by the UK’s leading retailers and as such it will interest academics, students and practitioners interested in retailing and corporate sustainability.

Sustainability-Related Publications Calendar Years 2015- 2016

Science.gov (United States)

The Center for the Advancement of Sustainability Innovations (CASI) was established by the U.S. Army Engineer Research and Development Center (ERDC...Department of Defense (DoD) achieve more sustainable facilities and operations. CASI provides the military with capabilities that enhance national security...and around the globe. CASI teams strive to measure sustainability innovations against the Triple Bottom Line of mission, environment, and community

ETHICAL ASPECTS OF SUSTAINABILITY

OpenAIRE

Amantova-Salmane, Liene

2015-01-01

Ethics can be defined as a reflection on nature and a definition of “the good”. Individuals value qualities and things dissimilarly, most visibly, but they also value their goods in different ways, in different relations to each other, for different reasons, and to different ends. These differences are very applicable to sustainability. In other words, sustainability cannot be achieved without attention to its ethical dimensions. The aim of this research is to examine the ethical aspects of s...

Is Sustainable Remediation Now a Self-Sustaining Process? an International Progress Report

Science.gov (United States)

Smith, J. W. N.

2014-12-01

Sustainable remediation - the consideration of environmental, social and economic factors associated with soil and groundwater risk-management options, to help select the best overall solution - has been a rapidly evolving topic in recent years. The first published reference[1] to 'sustainable remediation' was in the title of a 1999 conference paper by Kearney et al., (1999), but activity really accelerated in the middle-late 2000's, with establishment of a number of collaborative sustainable remediation groups and fora, and increased publication rates in the peer reviewed literature (Fig 1). Figure 1. Journal paper publications with search term 'sustainable remediation' (SCOPUS survey, 17 July 2014) This presentation will review the international progress of sustainable remediation concept development and application in regulatory and corporate decision-making processes. It will look back at what has already been achieved, provide an update on the latest initiatives and developments, and look forward to what the future of sustainable remediation might look like. Specifically it will describe: Sustainable remediation frameworks: synergies and international collaboration; Latest guidance and tools developed by the various sustainable remediation organisations (SuRFs), including the SuRF-UK Best Management Practices and Tier 1 Briefcase; Best practice standard development by ASTM and ISO; Regulatory acceptance of sustainable remediation, including incorporation into legislation, and the NICOLE - Common Forum Joint statement on 'risk-informed and sustainable remediation' in Europe; Examples of corporate adoption of sustainable remediation principles. The presentation will conclude with a look forward to a vision of sustainable remediation in 2020.

Sustainability Policy and Environmental Policy

OpenAIRE

John C. V. Pezzey

2001-01-01

A theoretical, representative agent economy with a depletable resource stock, polluting emissions and productive capital is used to contrast environmental policy, which internalises externalised environmental values, with sustainability policy, which achieves some form of intergenerational equity. The obvious environmental policy comprises an emissions tax and a resource stock subsidy, each equal to the respective external cost or benefit. Sustainability policy comprises an incentive affectin...

An Integrated, Multi-Stage, Multi-Scale Framework for Achieving Sustainable Process Synthesis-Intensification-Control

DEFF Research Database (Denmark)

Babi, Deenesh Kavi; Kumar Tula, Anjan; Mansouri, Seyed Soheil

The chemical and biochemical industry needs major reductions in energy consumption, waste generation, etc., in order to remain competitive through the design and operation of more sustainable chemical and biochemical processes. These required reductions can be addressed through process synthesis......-intensification-control, that is, the efficient use of raw materials (feedstock), the use of sustainable technologies and the design (and control) of processes that directly impact and improves sustainability/LCA factors. The unit operations concept, which has been sufficient until now, is one of the most used for performing...... process synthesis (and intensification) because it allows the association of tasks (functions) with the processing route to be followed. At the unit operations scale (Jaksland et al., 1995) and task scale (Siirola, 1996) alternatives are limited to existing (well-known) unit operations and therefore, may...

Sustainable Biofuels Development Center

Energy Technology Data Exchange (ETDEWEB)

Reardon, Kenneth F. [Colorado State Univ., Fort Collins, CO (United States)

2015-03-01

The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

Contributions to Sustainability by Communities and Individuals: Problems and Prospects

Energy Technology Data Exchange (ETDEWEB)

MacGregor, D.; Tonn, B.E.

1998-11-01

This report examines relationships between a comprehensive set of definitions of and viewpoints on the concept of Sustainability and the abilities of communities and individuals in the United States to meet the behavioral prescriptions inherent in these definitions and viewpoints. This research is timely because sustainability is becoming a cornerstone of national and international environmental strategies designed to simultaneously achieve environmental, economic, and social goals. In the United States, many communities have adopted sustainability principles as the foundation for both their environmental protection efforts and their socioeconomic development initiatives. This research is important because it highlights serious problems communities and inviduals may have in achieving sustainability expectations, and illustrates how much work is needed to help communities and individuals overcome numerous considerable and complex constraints to sustainability.

Sustainable winegrowing: current perspectives

Directory of Open Access Journals (Sweden)

Mariani A

2015-05-01

Full Text Available Angela Mariani,1 Antonella Vastola2 1Department of Economic and Legal Studies, University Parthenope, Naples, 2School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Potenza, Italy Abstract: The winegrowing sector worldwide is strongly committed to improving environmental and social sustainability. The aim of this work, based on a literature review, is to highlight current sustainability perspectives and the related main issues. There is a broad consensus that the challenge to achieve a greater spread of sustainable practices is to enhance environmental and social sustainability while maintaining economic viability. From the producers' point of view, the priority is to bridge the still substantial knowledge gaps in terms of perceived environmental benefits, economic benefits, and costs. Thus, an increased research effort focusing on the costs and benefits of different winegrowing practices and technical assistance with implementation might support their diffusion. Moreover, targeted marketing strategies are needed to: enhance consumers' involvement and their attitude toward sustainable wine; improve understanding and use of sustainable labels and claims; and raise awareness of some environmental credentials of wine packaging, mainly with reference to lightweight glass bottles. Keywords: winegrower, sustainability, wine, consumer, marketing strategies

Y-12 Site Sustainability Plan

Energy Technology Data Exchange (ETDEWEB)

Sherry, T D; Kohlhorst, D P; Little, S K

2011-12-01

The accomplishments to date and the long-range planning of the Y-12 Energy Management and Sustainability and Stewardship programs support the DOE and the National Nuclear Security Administration (NNSA) vision for a commitment to energy efficiency and sustainability and to achievement of the Guiding Principles. Specifically, the Y-12 vision is to support the Environment, Safety and Health Policy and the DOE Strategic Sustainability Performance Plan (SSPP) while promoting overall sustainability and reduction of greenhouse gas (GHG) emissions. Table ES.2 gives a comprehensive overview of Y-12's performance status and planned actions. B&W Y-12's Energy Management mission is to incorporate renewable energy and energy efficient technologies site-wide and to position Y-12 to meet NNSA energy requirement needs through 2025 and beyond. During FY 2011, the site formed a sustainability team (Fig. ES.1). The sustainability team provides a coordinated approach to meeting the various sustainability requirements and serves as a forum for increased communication and consistent implementation of sustainability activities at Y-12. The sustainability team serves as an information exchange mechanism to promote general awareness of sustainability information, while providing a system to document progress and to identify resources. These resources are necessary to implement activities that support the overall goals of sustainability, including reducing the use of resources and conserving energy. Additionally, the team's objectives include: (1) Foster a Y-12-wide philosophy to conserve resources; (2) Reduce the impacts of production operations in a cost-effective manner; (3) Increase materials recycling; (4) Use a minimum amount of energy and fuel; (5) Create a minimum of waste and pollution in achieving Y-12-strategic objectives; (6) Develop and implement techniques, technologies, process modifications, and programs that support sustainable acquisition; (7) Minimize the

The Roadmap to achieve EU goals on urban mobility

DEFF Research Database (Denmark)

Sørensen, Claus Hedegaard; Gudmundsson, Henrik; Schippl, Jens

2015-01-01

Is it possible to change urban mobility in Europe to achieve ambitious sustainability goals? If so, who should dowhat by when? These questions are answered in a new Roadmap on urban mobility prepared as part of the European FP7 research project TRANSFORuM.......Is it possible to change urban mobility in Europe to achieve ambitious sustainability goals? If so, who should dowhat by when? These questions are answered in a new Roadmap on urban mobility prepared as part of the European FP7 research project TRANSFORuM....

Working with human nature to achieve sustainability : exploring structural constraints and opportunities

NARCIS (Netherlands)

Kopnina, H.N.

2017-01-01

Sustainable production is often limited by structural factors such as industrial development, neoliberal democracy, growing population and globalization of consumer culture. Drawing on the work of some theorists linking unsustainability to universal psychological propensities, this article discusses

Web Content Analysis On Sustainable Campus Operation (SCO Initiatives

Directory of Open Access Journals (Sweden)

Razman Ruzaimah

2017-01-01

Full Text Available The purpose of this paper is to identify and analyse the current practices implemented in global universities for achieving sustainability throughout campus operations. This study adopted a web content analysis method where 30 international green universities’ websites have been thoroughly examined to identify common initiatives implemented to achieve sustainability through campus operations. The findings are ranked based on the implementation of these initiatives by participating universities. From the websites reviewed, as much as 31 initiatives have been identified as common initiatives frequently implemented by green universities to achieve sustainability in campus operations. It was found that the common initiatives frequently implemented by most of the universities include ‘Provide bin with clearly marked signs to increase the number of recycling items’, and ‘Generate electricity on campus by establishing power generation plants’ with 87% and 83% respectively. This paper fills the gap by presenting the investigation of sustainability initiatives from some of the major green universities internationally. It is suggested that higher education institutions, particularly Malaysian universities, initiate or manage their implementation of sustainable campus operation (SCO initiatives based on the findings of this research.

Global commitments and China's endeavors to promote health and achieve sustainable development goals.

Science.gov (United States)

Tan, Xiaodong; Wu, Qian; Shao, Haiyan

2018-04-12

With its immense population and as the largest developing country in the world, China has made remarkable achievements in health promotion at a relatively low cost. However, China is still faced with challenges such as changes of disease spectrum, the coming era of an aging society, and the risk of environmental pollution. On October 25, 2016, China formally passed the blueprint of "Healthy China 2030," working towards the national goal of reaching a health standard on par with developed countries by 2030, which was also a response to realize the 2030 United Nations Sustainable Development Goals. "Healthy China 2030" is comprised of 29 chapters that cover five health areas. China is sparing no effort to transfer from being merely the most populous country, to becoming a leading nation in health education. In "Healthy China 2030," collaborated construction and resource sharing were clearly stated as the core strategy. A shift in concentration towards coordinated development of health-based economy from a previous pursuit of rapid economic growth was also underlined. There are also several major issues, such as severely aging population, the burden of chronic diseases, the insufficiency of health expenditure, and the great demand on health protection, waiting to be dealt with during the implementation process of "Healthy China 2030". "Healthy China 2030" is a momentous move to enhance public health, which is also a response to the global commitments. We also need to rethink our approach to reach the living standards and maintain a better environment.

Sustainable development and climate change: Lessons from country studies

DEFF Research Database (Denmark)

Halsnæs, Kirsten; Shukla, P.; Garg, A.

2008-01-01

Sustainable development has been suggested as a framework for integrating development and climate change policies in developing countries. Mainstreaming climate change into sustainable development policies would allow these countries to achieve their development goals while addressing climate...... change. A number of research programmes have investigated how potential synergies could be achieved at national level and what kind of trade-offs between the various aspects of sustainable development have to be faced. An overview of these studies is provided, focusing on national case studies....... The energy and transportation sectors are covered in many studies, but some attention is also given to the infrastructure sector and water supply. Most existing development policies will not lead to a sustainable development pattern, since they insufficiently address climate change. However, good...

Specificities of sustainable tourism planning

Directory of Open Access Journals (Sweden)

Jegdić Vaso

2013-01-01

Full Text Available In the past two decades, companies have been mentioning achievement of sustainability in their activities as a target of companies, governments and non-profit organizations, although measuring the degree to which an organization conducts its activities in a sustainable manner, can be very difficult. Sustainable tourism development requires a process of planning and management that will unite the interests of various stakeholders in a sustainable and strategic way. It requires an understanding of the meaning of sustainable development and guiding values for promoting sustainable tourism. The paper points to the importance of cross-sector partnerships and the roles of different stakeholders in the planning of sustainable tourism projects. Special importance is given to the community of which a willingness to understand the impacts of tourism industry is expected, as well as various procedures of engagement in participatory planning, consensus building and conflict resolution among all stakeholders. The aim of this research is to find an optimal model of planning of sustainable tourism projects that would take into consideration the interests of all stakeholders and reflect the specificities imposed by the acceptance of the concept of sustainable development by all participants in the project.

Sustainability: Living within One’s Own Ecological Means

Directory of Open Access Journals (Sweden)

Lee Liu

2009-12-01

Full Text Available This paper provides a critical review of sustainability, including its definitions, dimensions, measurements, and practices, as well as approaches to achieve sustainability. It raises questions about conventional definitions and argues for taking into account the geographic dimension of sustainability for better understanding of the regional differences in sustainability and transition to sustainability. The paper proposes that sustainability should be defined as "living within one’s own ecological means." This definition pays attention to regional disparities in biocapacity and ecological footprint. It realizes that not all people’s present and future needs may be met in all regions of the world.

Development of Sustainable Rural Tourism

Directory of Open Access Journals (Sweden)

Sandra Kantar

2017-06-01

Full Text Available This paper presents a sociological view of possibilities for the development of sustainable rural tourism in Koprivnica-Krizevci county, which is located in the north-western part of Croatia. The possibilities for developing rural tourism within the concept of sustainable development have been researched through qualitative empirical research interview method. Research subjects were the owners of tourist farms, decision makers, experts and other stakeholders in the tourism development. Rural tourism represents an alternative to maritime tourism and is relatively undeveloped but important in terms of development of rural areas and family farms. This paper enables an insight into an integrated sustainability of rural tourism which consists of four dimensions: biologicalecological, economic, socio-cultural and political sustainability. In conclusion, integral sustainability in rural tourism is not achieved in all dimensions. Therefore, rural tourism could be a strategy for sustainable development for rural areas and also could be a tool for product differentiation for area that are at stagnation stage.

ABO alleles are linked with haplotypes of an erythroid cell-specific regulatory element in intron 1 with a few exceptions attributable to genetic recombination.

Science.gov (United States)

Nakajima, T; Sano, R; Takahashi, Y; Watanabe, K; Kubo, R; Kobayashi, M; Takahashi, K; Takeshita, H; Kominato, Y

2016-01-01

Recent investigation of transcriptional regulation of the ABO genes has identified a candidate erythroid cell-specific regulatory element, named the +5·8-kb site, in the first intron of ABO. Six haplotypes of the site have been reported previously. The present genetic population study demonstrated that each haplotype was mostly linked with specific ABO alleles with a few exceptions, possibly as a result of hybrid formation between common ABO alleles. Thus, investigation of these haplotypes could provide a clue to further elucidation of ABO alleles. © 2015 International Society of Blood Transfusion.

Collaboration and Sustainable Agri-Food Suply Chain: A Literature Review

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Prima Dania Wike Agustin

2016-01-01

Full Text Available Maintaining collaboration among the entire stages in the agri-food supply chain to achieve sustainability is complex. All the stakeholders involved in the activities have to prioritize their financial benefits without putting aside social development and environmental responsibilities. Some scholars have paid attention to this topic. The objective of this paper is to review current research on sustainable supply chain and collaboration model in agri-food industry. Sustainability aspects that consist of economic, environment, and social and the model of sustainable supply chain in agri-food industry are analyzed. Moreover, collaboration in sustainable agri-food supply chain management is also studied thoroughly from vertical and horizontal perspectives. The result shows that there are few studies focusing on the integrated collaboration to achieve sustainable supply chain system. Additionally, not all sustainable aspects are covered thoroughly. The scholars pays more attention to economic and environmental aspects than social aspects. Furthermore, some studies only focus on one type of collaboration in sustainable agri-food supply chain. Often, these studies do not even consider all elements in the triple bottom line.

Sustainable development and energy supply

International Nuclear Information System (INIS)

Levi, H.W.

1997-01-01

'Sustainable' is an old established term which has made a political career in the past ten years. The roots of this career extend back into the 18th century, when an economic concept of forest management was developed to replace yield maximization achieved by means of complete deforestation by yield optimization attained by conservative forest management. This latter type of forest management was termed 'sustainable'. The language used in today's sustainability debate was based on the idea of preserving the capital provided by nature and living on the interest. As a consequence, the term 'sustainable' became one of the key points in environmental policy and economic policy after the Brundtland report had been published (V. Hauff, 1987), which also constitutes the background to this article. (orig.) [de

The dual sustainability of wind energy

Energy Technology Data Exchange (ETDEWEB)

Welch, Jonathan B.; Venkateswaran, Anand [413 Hayden Hall, College of Business, Northeastern University, 360 Huntington Avenue, Boston, MA 02115 (United States)

2009-06-15

Academics, practitioners, and policy makers continue to debate the benefits and costs of alternative sources of energy. Environmental and economic concerns have yet to be fully reconciled. One view is that decisions that incorporate both society's concern with the environment and investors' desire for shareholder value maximization are more likely to be truly sustainable. We coin the term dual sustainability to mean the achievement of environmental and financial sustainability simultaneously. Many experts believe that wind energy can help to meet society's needs without harming future generations. It is clean and renewable. Because the fuel is free it provides the ultimate in energy independence. Wind energy has emerged as a leading prospect, in part, because it is considered by many to be environmentally sustainable. However, a key question that remains is whether wind energy is financially sustainable without the extensive government support that has helped to create and nurture this growth industry. Using reliable, proprietary data from field research, our analysis employs a capital budgeting framework to evaluate the financial economics of investments in wind energy. We find that because of the convergence of improved technology, greater efficiency, and with the increasing cost of traditional, competing sources such as oil and natural gas, wind energy is close to becoming self-sustaining financially without the extensive federal government support that exists today. Wind energy can provide the best of both worlds. It is sustainable from an environmental perspective and it is becoming sustainable financially. In short, those companies investing in wind energy will be able to do well by doing good. Perhaps the achievement of dual sustainability is true sustainability. Our research findings and dual sustainability have several interesting and important implications for public policy towards wind energy. All imply that public policy can now be

Emergy-based sustainability evaluation of wind power generation systems

International Nuclear Information System (INIS)

Yang, Jin; Chen, Bin

2016-01-01

Highlights: • Emergy is used to quantify the sustainability level of wind farms. • A GHG-based indicator is incorporated into emergetic accounting. • Possible pathways to achieve sustainable wind farm management are analyzed. - Abstract: With large-scale commercialization of wind technology, one must investigate economical and sustainable wind resource utilization. In this paper, emergy analysis is used to quantify the environmental pressure, renewability, economic efficiency, and sustainability of a typical wind power system, considering the lifetime stages from extraction and processing of raw materials and resources to the final product (electricity) via material transportation, construction and operation. Possible pathways to achieve sustainable management of wind energy supply chain were also analyzed based on scenario analysis. Results show that wind power is a promising means of substituting traditional fossil fuel-based power generation systems, with the lowest transformity of 4.49 × 10"4 sej/J, smaller environmental loading ratio of 5.84, and lower greenhouse gas emission intensity of 0.56 kg/kWh. To shed light on potential pathways to achieve sustainable and low-carbon wind energy supply chain management and make informed choices, a sensitivity analysis was done by establishing scenarios from the perspectives of material recycling and technical development. Results suggest that using new materials of lower energy intensity or recycled materials in upstream wind turbine manufacturing and construction materials are the most effective measures.

Energy sustainability: consumption, efficiency, and ...

Science.gov (United States)

One of the critical challenges in achieving sustainability is finding a way to meet the energy consumption needs of a growing population in the face of increasing economic prosperity and finite resources. According to ecological footprint computations, the global resource consumption began exceeding planetary supply in 1977 and by 2030, global energy demand, population, and gross domestic product are projected to greatly increase over 1977 levels. With the aim of finding sustainable energy solutions, we present a simple yet rigorous procedure for assessing and counterbalancing the relationship between energy demand, environmental impact, population, GDP, and energy efficiency. Our analyses indicated that infeasible increases in energy efficiency (over 100 %) would be required by 2030 to return to 1977 environmental impact levels and annual reductions (2 and 3 %) in energy demand resulted in physical, yet impractical requirements; hence, a combination of policy and technology approaches is needed to tackle this critical challenge. This work emphasizes the difficulty in moving toward energy sustainability and helps to frame possible solutions useful for policy and management. Based on projected energy consumption, environmental impact, human population, gross domestic product (GDP), and energy efficiency, for this study, we explore the increase in energy-use efficiency and the decrease in energy use intensity required to achieve sustainable environmental impact le

Looking for Sustainable Urban Mobility through Bayesian Networks

Directory of Open Access Journals (Sweden)

Giovanni Fusco

2004-11-01

Full Text Available There is no formalised theory of sustainable urban mobility systems. Observed patterns of urban mobility are often considered unsustainable. But we don’t know what a city with sustainable mobility should look like. It is nevertheless increasingly apparent that the urban mobility system plays an important role in the achievement of the city’s wider sustainability objectives.In this paper we explore the characteristics of sustainable urban mobility systems through the technique of Bayesian networks. At the frontier between multivariate statistics and artificial intelligence, Bayesian networks provide powerful models of causal knowledge in an uncertain context. Using data on urban structure, transportation offer, mobility demand, resource consumption and environmental externalities from seventy-five world cities, we developed a systemic model of the city-transportation-environment interaction in the form of a Bayesian network. The network could then be used to infer the features of the city with sustainable mobility.The Bayesian model indicates that the city with sustainable mobility is most probably a dense city with highly efficient transit and multimodal mobility. It produces high levels of accessibility without relying on a fast road network. The achievement of sustainability objectives for urban mobility is probably compatible with all socioeconomic contexts.By measuring the distance of world cities from the inferred sustainability profile, we finally derive a geography of sustainability for mobility systems. The cities closest to the sustainability profile are in Central Europe as well as in affluent countries of the Far East. Car-dependent American cities are the farthest from the desired sustainability profile.

AN OVERVIEW OF SUSTAINABLE DEVELOPMENT INDICATORS

Directory of Open Access Journals (Sweden)

Cristian CRISTU

2016-12-01

Full Text Available Sustainable development requires better quality of life for present and future generations. Additional data is required to measure lasting progress, that tracks economic growth. The objectives that take these aspects into consideration should be accompanied by economic, social, environmental and demographic indicators. Thus, sustainable development indicators satisfy these requirements. The articles makes an analysis of the main indicators of sustainable development. Even though it is important to observe them at a macro, European level, it is necessary to take into consideration the specific situation existing at a local and regional level, as well. Equally important is the integration of objectives aimed at sustainable development into the national policies. Economic improvement can be achieved through jobs and sustainable consumption.

ROLE OF STEM CELL FACTOR IN THE REACTIVATION OF HUMAN FETAL HEMOGLOBIN

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Marco Gabbianelli

2009-11-01

In vitro and in vivo models have led to the identification of several chemical compounds able to reactivate HbF synthesis in adult erythroid cells. Although the impact of these HbF inducers, including hypomethylating agents, histone deacetylase inhibitors and hydroxyurea, was clear on the natural history of sickle cell anemia, the benefit on the clinical course of -thalassemia was only limited: particularly, the toxicity and the modest increase in γ-globin reactivation indicated the need for improved agents able to induce higher levels of HbF. In the present review we describe the biologic properties of Stem Cell Factor (SCF, a cytokine sustaining the survival and proliferation of erythroid cells, that at pharmacological doses acts as a potent stimulator of HbF synthesis in adult erythroid cells.

Sustainable urban development

DEFF Research Database (Denmark)

Jensen, Jesper Ole; Christensen, Toke Haunstrup; Gram-Hanssen, Kirsten

Sustainability in urban planning has a long history and it has been a widespread solution to build high and compact in order to minimise the need for transportation, land use and heating. Recent research, however, points towards the need for a supplementary approach which includes the consumer...... behaviour of the household. This approach necessarily has to work from below and include the citizens, as it is their daily practices that have to be challenged. This article reviews the literature of to what extent compact cities are the most sustainable and it use lifestyle interpretations of urbane forms...... to challenge the compact cities approach. As an alternative or supplementary approach the article introduce practice theory as a way to understand consumption and it gives examples on how this approach can be used to inspire local authorities to alternative and supplementary strategies of achieving sustainable...

Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors

Energy Technology Data Exchange (ETDEWEB)

Cai, Ying; Xu, Zhixiong; Xie, Jingping [Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Ham, Amy-Joan L. [Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Koury, Mark J. [Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Tennessee Valley VA Healthcare System, Nashville, TN 37212 (United States); Hiebert, Scott W. [Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Brandt, Stephen J., E-mail: stephen.brandt@vanderbilt.edu [Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Tennessee Valley VA Healthcare System, Nashville, TN 37212 (United States)

2009-12-11

The TAL1 (or SCL) gene, originally discovered through its involvement by a chromosomal translocation in T-cell acute lymphoblastic leukemia, encodes a basic helix-loop-helix (bHLH) transcription factor essential for hematopoietic and vascular development. To identify its interaction partners, we expressed a tandem epitope-tagged protein in murine erythroleukemia (MEL) cells and characterized affinity-purified Tal1-containing complexes by liquid chromatography-tandem mass spectrometry analysis. In addition to known interacting proteins, two proteins related to the Eight-Twenty-One (ETO) corepressor, Eto2/Mtg16 and Mtgr1, were identified from the peptide fragments analyzed. Tal1 interaction with Eto2 and Mtgr1 was verified by coimmunoprecipitation analysis in Tal1, Eto2-, and Mtgr1-transfected COS-7 cells, MEL cells expressing V5 epitope-tagged Tal1 protein, and non-transfected MEL cells. Mapping analysis with Gal4 fusion proteins demonstrated a requirement for the bHLH domain of Tal1 and TAF110 domain of Eto2 for their interaction, and transient transfection and glutathione S-transferase pull-down analysis showed that Mtgr1 and Eto2 enhanced the other's association with Tal1. Enforced expression of Eto2 in differentiating MEL cells inhibited the promoter of the Protein 4.2 (P4.2) gene, a direct target of TAL1 in erythroid progenitors, and transduction of Eto2 and Mtgr1 augmented Tal1-mediated gene repression. Finally, chromatin immunoprecipitation analysis revealed that Eto2 occupancy of the P4.2 promoter in MEL cells decreased with differentiation, in parallel with a decline in Eto2 protein abundance. These results identify Eto2 and Mtgr1 as authentic interaction partners of Tal1 and suggest they act as heteromeric corepressors of this bHLH transcription factor during erythroid differentiation.

Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors

International Nuclear Information System (INIS)

Cai, Ying; Xu, Zhixiong; Xie, Jingping; Ham, Amy-Joan L.; Koury, Mark J.; Hiebert, Scott W.; Brandt, Stephen J.

2009-01-01

The TAL1 (or SCL) gene, originally discovered through its involvement by a chromosomal translocation in T-cell acute lymphoblastic leukemia, encodes a basic helix-loop-helix (bHLH) transcription factor essential for hematopoietic and vascular development. To identify its interaction partners, we expressed a tandem epitope-tagged protein in murine erythroleukemia (MEL) cells and characterized affinity-purified Tal1-containing complexes by liquid chromatography-tandem mass spectrometry analysis. In addition to known interacting proteins, two proteins related to the Eight-Twenty-One (ETO) corepressor, Eto2/Mtg16 and Mtgr1, were identified from the peptide fragments analyzed. Tal1 interaction with Eto2 and Mtgr1 was verified by coimmunoprecipitation analysis in Tal1, Eto2-, and Mtgr1-transfected COS-7 cells, MEL cells expressing V5 epitope-tagged Tal1 protein, and non-transfected MEL cells. Mapping analysis with Gal4 fusion proteins demonstrated a requirement for the bHLH domain of Tal1 and TAF110 domain of Eto2 for their interaction, and transient transfection and glutathione S-transferase pull-down analysis showed that Mtgr1 and Eto2 enhanced the other's association with Tal1. Enforced expression of Eto2 in differentiating MEL cells inhibited the promoter of the Protein 4.2 (P4.2) gene, a direct target of TAL1 in erythroid progenitors, and transduction of Eto2 and Mtgr1 augmented Tal1-mediated gene repression. Finally, chromatin immunoprecipitation analysis revealed that Eto2 occupancy of the P4.2 promoter in MEL cells decreased with differentiation, in parallel with a decline in Eto2 protein abundance. These results identify Eto2 and Mtgr1 as authentic interaction partners of Tal1 and suggest they act as heteromeric corepressors of this bHLH transcription factor during erythroid differentiation.

Short Intervention, Sustained Effects: Promoting Students’ Math Competence Beliefs, Effort, and Achievement

NARCIS (Netherlands)

Brisson, Brigitte Maria; Dicke, Anna Lena; Gaspard, Hanna; Häfner, Isabelle; Flunger, Barbara|info:eu-repo/dai/nl/412516322; Nagengast, Benjamin; Trautwein, Ulrich

2017-01-01

The present study investigated the effectiveness of two short relevance interventions (writing a text or evaluating quotations about the utility of mathematics) using a sample of 1,916 students in 82 math classrooms in a cluster randomized controlled experiment. Short-term and sustained effects (6

Sustainable consumption and production in the food supply chain

DEFF Research Database (Denmark)

Govindan, Kannan

2018-01-01

Increased globalization and a growing world population have a great impact on the sustainability of supply chains, especially within the food industry. The way food is produced, processed, transported, and consumed has a great impact on whether sustainability is achieved throughout the whole food...... supply chain. Due to the complexity that persists in coordinating the members of food supply chain, food wastage has increased over the past few years. To achieve sustainable consumption and production (SCP), food industry stakeholders need to be coordinated and to have their views reflected...... in an optimized manner. However, not much research has been done concerning the influence of stakeholders and supply chain members’ coordination in the food industry's SCP context. To facilitate the theory development for SCP, in this work, a short literature review on sustainable supply chain management...

A Model for Sustainable Value Creation in Supply Chain

OpenAIRE

KORDİTABAR, Seyed Behzad

2015-01-01

Abstract. In order to survive, every company needs to achieve sustainable profitability, which is impossible unless there is sustainable value creation. Regarding the fact that sustainability is closely related with concepts of supply chain management, the present paper intends to propose through a conceptual theorization approach a new comprehensive model drawing on concepts of value creation and sustainability from the perspective of supply chain, specifying the dimensions contributing to s...

Predicting the Performance and Survival of Islamic Banks in Malaysia to Achieve Growth Sustainability

Directory of Open Access Journals (Sweden)

Mazuin Sapuan Noraina

2017-01-01

Full Text Available In Malaysia, the growth of the Islamic financial industry has increased tremendously in line with the Government’s ambition to make Malaysia as an international hub for Islamic finance since 2010. With the increasing number of foreign players in this industry plus with the increasing demand from domestic and foreign customers would further enhance the possibility for Malaysia to achieve this ambition. Currently, according to the Economic Transformation Programme, 2012 Malaysia is the world’s third largest market for Shariah assets that cover Islamic banks, Takaful, and sukuk. Malaysia as one of the main contributors to the global Islamic financial assets with Islamic assets in Malaysia grew by 23.8% in 2011 from RM350.8bil to RM434.6bil. The issues of predicting the performance and the survival of Islamic Banks in Malaysia become amongst crucial issues in academic research. By employing multi – layer perceptron neural network and pooled regression, we found that total assets/ size of the Islamic banks (GROWTH have high weightage and significantly influence in predicting the performance and the survival of Islamic banks in Malaysia. With the increasing number of Islamic banking institutions in Malaysia, this study can give insight on the sustainability of the Islamic banking system in Malaysia for the benefit of the investors, shareholder and depositors.

Y-12 Site Sustainability Plan

Energy Technology Data Exchange (ETDEWEB)

Spencer, Charles G

2012-12-01

The accomplishments to date and the long-range planning of the Y-12 Energy Management and Sustainability and Stewardship programs support the U.S. Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) vision for a commitment to energy effi ciency and sustainability and to achievement of the Guiding Principles. Specifi cally, the Y-12 vision is to support the Environment, Safety and Health Policy and the DOE Strategic Sustainability Performance Plan, while promoting overall sustainability and reduction of greenhouse gas emissions. The mission of the Y-12 Energy Management program is to incorporate energy-effi cient technologies site-wide and to position Y-12 to meet NNSA energy requirement needs through 2025 and beyond. The plan addresses greenhouse gases, buildings, fleet management, water use, pollution prevention, waste reduction, sustainable acquisition, electronic stewardship and data centers, site innovation and government-wide support.

Nuclear power and sustainable development

International Nuclear Information System (INIS)

Sandklef, S.

2000-01-01

Nuclear Power is a new, innovative technology for energy production, seen in the longer historic perspective. Nuclear technology has a large potential for further development and use in new applications. To achieve this potential the industry needs to develop the arguments to convince policy makers and the general public that nuclear power is a real alternative as part of a sustainable energy system. This paper examines the basic concept of sustainable development and gives a quality review of the most important factors and requirements, which have to be met to quality nuclear power as sustainable. This paper intends to demonstrate that it is not only in minimising greenhouse gas emissions that nuclear power is a sustainable technology, also with respect to land use, fuel availability waste disposal, recycling and use of limited economic resources arguments can be developed in favour of nuclear power as a long term sustainable technology. It is demonstrated that nuclear power is in all aspects a sustainable technology, which could serve in the long term with minimal environmental effects and at minimum costs to the society. And the challenge can be met. But to achieve need political leadership is needed, to support and develop the institutional and legal framework that is the basis for a stable and long-term energy policy. Industry leaders are needed as well to stand up for nuclear power, to create a new industry culture of openness and communication with the public that is necessary to get the public acceptance that we have failed to do so far. The basic facts are all in favour of nuclear power and they should be used

CONCEPT OF SUSTAINABILITY – A LOGICAL APPROACH

Directory of Open Access Journals (Sweden)

EMIL DINGA

2011-04-01

Full Text Available The paper aims to achieve a definition of the concept of sustainability and of sustainable system from a logical perspective. In this respect, it introduces and defines (through the sufficiency predicates the concept of logically vivid system and, on this basis, are discussed a logical concept of sustainability, respectively of a sustainable system in general are discussed and built up. Sustainability is considered in light of identity preservation of the systems, as a static anchor, on one hand, and of the concept of automatic stabilizers as a dynamic anchor on the other side. Finally, the two sufficiency conditions for a logically vivid system be sustainable are identified: the presence of hyper-cycles, respectively the absence of positive feed-back.

In place of fear: aligning health care planning with system objectives to achieve financial sustainability.

Science.gov (United States)

Birch, Stephen; Murphy, Gail Tomblin; MacKenzie, Adrian; Cumming, Jackie

2015-04-01

The financial sustainability of publicly funded health care systems is a challenge to policymakers in many countries as health care absorbs an ever increasing share of both national wealth and government spending. New technology, aging populations and increasing public expectations of the health care system are often cited as reasons why health care systems need ever increasing funding as well as reasons why universal and comprehensive public systems are unsustainable. However, increases in health care spending are not usually linked to corresponding increases in need for care within populations. Attempts to promote financial sustainability of systems such as limiting the range of services is covered or the groups of population covered may compromise their political sustainability as some groups are left to seek private cover for some or all services. In this paper, an alternative view of financial sustainability is presented which identifies the failure of planning and management of health care to reflect needs for care in populations and to integrate planning and management functions for health care expenditure, health care services and the health care workforce. We present a Health Care Sustainability Framework based on disaggregating the health care expenditure into separate planning components. Unlike other approaches to planning health care expenditure, this framework explicitly incorporates population health needs as a determinant of health care requirements, and provides a diagnostic tool for understanding the sources of expenditure increase. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Extended flow cytometry characterization of normal bone marrow progenitor cells by simultaneous detection of aldehyde dehydrogenase and early hematopoietic antigens: implication for erythroid differentiation studies

Directory of Open Access Journals (Sweden)

Pascariello Caterina

2008-05-01

Full Text Available Abstract Background Aldehyde dehydrogenase (ALDH is a cytosolic enzyme highly expressed in hematopoietic precursors from cord blood and granulocyte-colony stimulating factor mobilized peripheral blood, as well as in bone marrow from patients with acute myeloblastic leukemia. As regards human normal bone marrow, detailed characterization of ALDH+ cells has been addressed by one single study (Gentry et al, 2007. The goal of our work was to provide new information about the dissection of normal bone marrow progenitor cells based upon the simultaneous detection by flow cytometry of ALDH and early hematopoietic antigens, with particular attention to the expression of ALDH on erythroid precursors. To this aim, we used three kinds of approach: i multidimensional analytical flow cytometry, detecting ALDH and early hematopoietic antigens in normal bone marrow; ii fluorescence activated cell sorting of distinct subpopulations of progenitor cells, followed by in vitro induction of erythroid differentiation; iii detection of ALDH+ cellular subsets in bone marrow from pure red cell aplasia patients. Results In normal bone marrow, we identified three populations of cells, namely ALDH+CD34+, ALDH-CD34+ and ALDH+CD34- (median percentages were 0.52, 0.53 and 0.57, respectively. As compared to ALDH-CD34+ cells, ALDH+CD34+ cells expressed the phenotypic profile of primitive hematopoietic progenitor cells, with brighter expression of CD117 and CD133, accompanied by lower display of CD38 and CD45RA. Of interest, ALDH+CD34- population disclosed a straightforward erythroid commitment, on the basis of three orders of evidences. First of all, ALDH+CD34- cells showed a CD71bright, CD105+, CD45- phenotype. Secondly, induction of differentiation experiments evidenced a clear-cut expression of glycophorin A (CD235a. Finally, ALDH+CD34- precursors were not detectable in patients with pure red cell aplasia (PRCA. Conclusion Our study, comparing surface antigen expression of

Y-12 Site-Sustainability Plan 2010

Energy Technology Data Exchange (ETDEWEB)

Sherry, T. D.; Kohlhorst, D. P.; Little, S. K.

2010-12-01

The accomplishments to date and the long-range planning of the Y-12 National Security Complex Energy Management program support the Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) vision for a commitment to energy efficiency and sustainability and to achievement of the guiding principles. The site is diligently working toward establishing and prioritizing projects to reach the goals that Executive Orders 13514 and 13423 set forth. Y-12 is working to communicate its sustainment vision through procedural, engineering, operational, and management practices. The site will make informed decisions that are based on the application of the fi ve guiding principles for High Performance Sustainable Buildings (HPSBs) to the maximum extent possible. Current limitations in achievement of the goals lie in the existing Future Years National Security Program funding profiles. Y-12 will continue to execute energy projects as funding becomes available or as they can be accomplished incrementally within existing funding profiles. All efforts will be made to integrate energy initiatives with ongoing site mission objectives. Figures ES.1-ES.4 show some examples of sustainability activities at the Y-12 Complex.

Sustainable development in agriculture, food and nutrition--a patent analysis.

Science.gov (United States)

Vani, Kohila P; Doble, Mukesh

2011-05-01

The paper discusses the patents that have been filed in the areas of sustainable development in agriculture, food and nutrition and use of natural resources in achieving this goal. A large number of patents deal with the production of fertilizers from animal manure, plant sources and other organic wastes, which are more sustainable that the chemical fertilizers that are being currently used. Sustainability in agriculture is achieved in developing processes for the manufacture of biopesticides/insecticides and bioactive agricultural products. Development of novel sustainable agricultural processes has also been the focus of researchers and technologists. Plant derived nutritious food products are sustainable and can cater for the growing population burden. This has been the focus of several patents. Processes for enhancing the nutrition in food also serve the purpose of catering for the under nourished population.

Methods and tools for sustainable chemical process design

DEFF Research Database (Denmark)

Loureiro da Costa Lira Gargalo, Carina; Chairakwongsa, Siwanat; Quaglia, Alberto

2015-01-01

As the pressure on chemical and biochemical processes to achieve a more sustainable performance increases, the need to define a systematic and holistic way to accomplish this is becoming more urgent. In this chapter, a multilevel computer-aided framework for systematic design of more sustainable...

Sustainable Offering Practices Through Stakeholders Engagement

Directory of Open Access Journals (Sweden)

Bijay Prasad Kushwaha

2018-02-01

Full Text Available Sustainable development is achieved by satisfying the current ends without shrinking the existing means which can serve as needs for the society in the future. It has become global motive and responsibility of present community to utilize resources in an optimum way with minimum environmental damage. The objective of this paper is to study theoretical framework and practical approaches on sustainable offering practices through customer engagement. The study has also examined the opportunities and challenges of sustainable offering practices in India. The study is based on a previous study and secondary data has been used for analysis. The outcome revealed the process for successful sustainable offering practices in context of Indian consumers. The analysis has helped to understand different practices of sustainable offering through engaging stakeholders.

It is not easy being green: increasing sustainable public procurement behaviour

NARCIS (Netherlands)

Grandia, J.; Steijn, A.J.; Kuipers, B.S.

2015-01-01

To achieve greater sustainability, governments need to continuously adapt their purchasing activities to innovations in the market. Sustainable procurement is a decision-making process in which the decisions of procurers determine if the full potential of sustainable procurement is used. The

It is not easy being green: increasing sustainable public procurement behaviour

NARCIS (Netherlands)

J. Grandia (Jolien); A.J. Steijn (Bram); B.S. Kuipers (Ben)

2015-01-01

markdownabstractTo achieve greater sustainability, governments need to continuously adapt their purchasing activities to innovations in the market. Sustainable procurement is a decision-making process in which the decisions of procurers determine if the full potential of sustainable procurement is

Strengthening the partnership between routine immunization and the global polio eradication initiative to achieve eradication and assure sustainability.

Science.gov (United States)

Abdelwahab, Jalaa; Dietz, Vance; Eggers, Rudolf; Maher, Christopher; Olaniran, Marianne; Sandhu, Hardeep; Vandelaer, Jos

2014-11-01

Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, the number of polio endemic countries has declined from 125 to 3 in 2013. Despite this remarkable achievement, ongoing circulation of wild poliovirus in polio-endemic countries and the increase in the number of circulating vaccine-derived poliovirus cases, especially those caused by type 2, is a cause for concern. The Polio Eradication and Endgame Strategic Plan 2013-2018 (PEESP) was developed and includes 4 objectives: detection and interruption of poliovirus transmission, containment and certification, legacy planning, and a renewed emphasis on strengthening routine immunization (RI) programs. This is critical for the phased withdrawal of oral poliovirus vaccine, beginning with the type 2 component, and the introduction of a single dose of inactivated polio vaccine into RI programs. This objective has inspired renewed consideration of how the GPEI and RI programs can mutually benefit one another, how the infrastructure from the GPEI can be used to strengthen RI, and how a strengthened RI can facilitate polio eradication. The PEESP is the first GPEI strategic plan that places strong and clear emphasis on the necessity of improving RI to achieve and sustain global polio eradication. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

White paper on geothermal sustainability; Grundlagenpapier 'Geothermal sustainability - A review with identified research needs'

Energy Technology Data Exchange (ETDEWEB)

Rybach, L.; Megel, T.

2006-12-15

This comprehensive appendix contained in a comprehensive annual report 2006 for the Swiss Federal Office of Energy (SFOE) reviews research needs identified in connection with the topic of geothermal sustainability. It is noted that excessive production often pursued - mostly for economical reasons - can lead to the depletion of heat reservoirs. Sustainable production can be achieved with lower production rates and still provide similar total energy yields. The regeneration of geothermal resources following exploitation is discussed. The need for further research into geothermal production sustainability is noted. A doublet system realised in Riehen, Switzerland, is discussed, as is an Enhanced Geothermal System EGS using circulation in fractured rock layers. Research still needed is noted.

Rapid and sustained cost management

International Nuclear Information System (INIS)

Hanson, D.

2009-01-01

Accenture helps clients develop comprehensive, process-driven strategies for rapid and sustained cost management that leverage deep insights and analytics. This approach enables companies to gain operating cost advantages by rationalizing, simplifying and automating current operating capabilities. It drives structural cost advantages by optimizing business mix, capital structure, organizational structure and geographic presence. This paper discussed how successful companies achieve high performance during times of economic turmoil. It also discussed the value of the winner's strategy in terms of rapid and sustained cost management (RSCM). It discussed how Accenture operates and its leveraged capabilities, improved efficiency, margins and cash flow while maintaining customer service levels. Building structural advantage and the Accenture difference were also discussed. It was concluded that RSCM is one vital way that Accenture can help companies achieve success. 4 figs

Sustaining responsible tourism – The case of Kerala.

OpenAIRE

Kokkranikal, Jithendran; Chettiparamb, Angelique

2015-01-01

Responsible tourism is a concept that overlaps significantly with concepts of sustainable tourism, ethical tourism, pro-poor tourism and integrated tourism (Chettiparamb and Kokkranikal, 2012). Responsible tourism emphasises the role of businesses in achieving sustainability and can be seen as yet another concept within the sustainable tourism genre, which comprises many forms of tourism such as ecotourism, ethical tourism, alternative tourism, green tourism, soft tourism, etc. Responsible to...

Ultrasonography shows disappearance of monosodium urate crystal deposition on hyaline cartilage after sustained normouricemia is achieved.

Science.gov (United States)

Thiele, Ralf G; Schlesinger, Naomi

2010-02-01

This study aimed at determining whether lowering serum urate (SU) to less than 6 mg/dl in patients with gout affects ultrasonographic findings. Seven joints in five patients with monosodium urate (MSU) crystal proven gout and hyperuricemia were examined over time with serial ultrasonography. Four of the five patients were treated with urate lowering drugs (ULDs) (allopurinol, n = 3; probenecid, n = 1). One patient was treated with colchicine alone. Attention was given to changes in a hyperechoic, irregular coating of the hyaline cartilage in the examined joints (double contour sign or "urate icing"). This coating was considered to represent precipitate of MSU crystals. Index joints included metacarpophalangeal (MCP) joints (n = 2), knee joints (n = 3), and first metatarsophalangeal (MTP) joints (n = 2). The interval between baseline and follow-up images ranged from 7 to 18 months. Serial SU levels were obtained during the follow-up period. During the follow-up period, three patients treated with ULD (allopurinol, n = 2; probenecid, n = 1) achieved a SU level of or =7 mg/dl. In one patient treated with allopurinol, SU levels improved from 13 to 7 mg/dl during the follow-up period. Decrease, but not resolution of the hyperechoic coating was seen in this patient. In the patient treated with colchicine alone, SU levels remained >8 mg/dl, and no sonographic change was observed. In our patients, sonographic signs of deposition of MSU crystals on the surface of hyaline cartilage disappeared completely if sustained normouricemia was achieved. This is the first report showing that characteristic sonographic changes are influenced by ULDs once SU levels remain studies are needed to further assess these potentially important findings.

Using Sustainability Engineering to Gain Universal Sustainability Efficiency

Directory of Open Access Journals (Sweden)

Aleksandras Vytautas Rutkauskas

2012-05-01

Full Text Available The present article is an attempt to perceive the universal sustainability observable in an individual country or region, where the religious, political, social-demographic, economic, environmental, creative, technological and investment subsystems are revealed not only through the vitality of spiritual and material existence media, but rather through the signs of the development of these subsystems as self-assembled units through the erosion of their interaction. The problem of optimal allocation of investment resources among the separate sustainability’s subsystems was addressed by means of expert methods and techniques of portfolio methodology which will enable the achievement of the enshrined universal sustainability standards. A country-specific index composition of sustainability subsystems’ indices was chosen as the universal sustainability index for the specific country. The index in its dynamics is perceived as a random process. While projecting its state and evaluating its power, i.e., the impact of the subsystem efficiency in a particular moment, this power is measured by the level of the index and the reliability or guarantee of an appropriate level. To solve the problem of investment resources allocation, the idea of Markowitz Random Field was invoked in order to reach the maximum power of sustainability index while applying the technical solution—the so-called “GoldSim” system. Engineering is a methodology that aspires to reveal the core attributes of complex systems and instruments in order to manage the possibility to influence these properties for the systems. Experimental expert evaluation and case study is performed on Lithuanian data.

SUSTAINABLE DEVELOPMENT, A MULTIDIMENSIONAL CONCEPT

Directory of Open Access Journals (Sweden)

TEODORESCU ANA MARIA

2015-06-01

Full Text Available Sustainable development imposed itself as a corollary of economic term "development". Sustainable development is meant to be the summation of economic, environmental and social considerations for the present and especially for the future. The concept of sustainable development plays an important role in european and global meetings since 1972, the year it has been set for the first time. Strategies necessary to achieve the objectives of sustainable development have been developed, indicators meant to indicate the result of the implementation of policies have been created, national plans were oriented towards achieving the proposed targets. I wanted to highlight the multidimensional character of the concept of sustainable development. Thus, using specialized national and international literature, I have revealed different approaches of one pillar to the detriment of another pillar depending on the specific field. In the different concepts of sustainable development, the consensus is undoubtedly agreed on its components: economic, social, environmental. Based on this fact, the concept of sustainability has different connotations depending on the specific content of each discipline: biology, economics, sociology, environmental ethics. The multidimensional valence of sustainable development consists of three pillars ability to act together for the benefit of present and future generations. Being a multidimensional concept, importance attached to a pillar over another is directed according to the particularities of each field: in economy profit prevails, in ecology care of natural resources is the most important, the social aims improving human living conditions. The challenge of sustainable development is to combine all the economic, environmental and social benefits and the present generation to come. Ecological approach is reflected in acceptance of limited natural resources by preserving natural capital. In terms of the importance of

FHL2 interacts with CALM and is highly expressed in acute erythroid leukemia

International Nuclear Information System (INIS)

Pašaliç, Z; Greif, P A; Jurinoviç, V; Mulaw, M; Kakadia, P M; Tizazu, B; Fröhlich-Archangelo, L; Krause, A; Bohlander, S K

2011-01-01

The t(10;11)(p13;q14) translocation results in the fusion of the CALM (clathrin assembly lymphoid myeloid leukemia protein) and AF10 genes. This translocation is observed in acute myeloblastic leukemia (AML M6), acute lymphoblastic leukemia (ALL) and malignant lymphoma. Using a yeast two-hybrid screen, the four and a half LIM domain protein 2 (FHL2) was identified as a CALM interacting protein. Recently, high expression of FHL2 in breast, gastric, colon, lung as well as in prostate cancer was shown to be associated with an adverse prognosis. The interaction between CALM and FHL2 was confirmed by glutathione S-transferase-pulldown assay and co-immunoprecipitation experiments. The FHL2 interaction domain of CALM was mapped to amino acids 294–335 of CALM. The transcriptional activation capacity of FHL2 was reduced by CALM, but not by CALM/AF10, which suggests that regulation of FHL2 by CALM might be disturbed in CALM/AF10-positive leukemia. Extremely high expression of FHL2 was seen in acute erythroid leukemia (AML M6). FHL2 was also highly expressed in chronic myeloid leukemia and in AML with complex aberrant karyotype. These results suggest that FHL2 may play an important role in leukemogenesis, especially in the case of AML M6

Y-12 Site Sustainability Plan

Energy Technology Data Exchange (ETDEWEB)

Erhart, Steven C. [National Nuclear Security Administration (NNSA), Washington, DC (United States); Spencer, Charles G. [Y-12 National Security Complex, Oak Ridge, TN (United States)

2013-12-01

The accomplishments to date and the long-range planning of the Y-12 Energy Management and Sustainability and Stewardship programs support the U.S. Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) vision for a commitment to energy effi ciency and sustainability and to achievement of the Guiding Principles. Specifi cally, the Y-12 vision is to support the Environment, Safety and Health Policy and the DOE Strategic Sustainability Performance Plan (SSPP), while promoting overall sustainability and reduction of greenhouse gas (GHG) emissions. The mission of the Y-12 Energy Management program is to incorporate energy-efficient technologies site-wide and to position Y-12 to meet NNSA energy requirement needs through 2025 and beyond. This plan addresses: Greenhouse Gas Reduction and Comprehensive Greenhouse Gas Inventory; Buildings, ESPC Initiative Schedule, and Regional and Local Planning; Fleet Management; Water Use Efficiency and Management; Pollution Prevention and Waste Reduction; Sustainable Acquisition; Electronic Stewardship and Data Centers; Renewable Energy; Climate Change; and Budget and Funding.

Identifying a Human Right to Access Sustainable Energy Services in International Human Rights Law (SDG 7)? (LRN Law and Sustainability Conference)

NARCIS (Netherlands)

Hesselman, Marlies

2017-01-01

This paper assessed whether a right to sustainable energy services access can be found in international human rights law, possibly in support of achieving UN Sustainable Development Goal 7. According to SDG 7.1, States are expected to strive for the implementation of "universal access to modern,

Sustainability and Interest Group Participation in City Politics

Directory of Open Access Journals (Sweden)

Kent E. Portney

2013-05-01

Full Text Available Many cities across the United States have embraced programs aimed at achieving greater sustainability. This may seem surprising, particularly since adopting aggressive environmental protection programs is regarded by some as inimical to economic development. An alternative perspective is that in the modern city sustainability can be part of an economic development strategy. What is largely missing from the literature on sustainable cities’ policies and programs is systematic analysis of the political dynamics that seem to affect support for, and adoption and implementation of, local sustainability policies. To explore the actual behavior of cities with respect to sustainability and economic development policies, two original databases on 50 large U.S. cities are used. One source of data is composed of survey responses from city councilors, agency administrators, and leaders of local advocacy groups in each of these cities. The second database contains information as to what these 50 cities actually do in terms of sustainable programs and policies. In testing a series of hypotheses, findings suggest that: a high number of programs aimed at achieving sustainability is linked to the inclusion of environmental advocacy groups; that this relationship is not compromised by business advocacy; and that inclusion of environmental groups in policymaking seems to be supported, rather than impeded, by high rates of economic growth by the cities.

Community Health Global Network and Sustainable Development

Directory of Open Access Journals (Sweden)

Rebekah Young

2016-01-01

Full Text Available With the achievements, failures and passing of the Millennium Development Goals (MDG, the world has turned its eyes to the Sustainable Development Goals (SDG, designed to foster sustainable social, economic and environmental development over the next 15 years.(1 Community-led initiatives are increasingly being recognised as playing a key role in realising sustainable community development and in the aspirations of universal healthcare.(2 In many parts of the world, faith-based organisations are some of the main players in community-led development and health care.(3 Community Health Global Network (CHGN creates links between organisations, with the purpose being to encourage communities to recognise their assets and abilities, identify shared concerns and discover solutions together, in order to define and lead their futures in sustainable ways.(4 CHGN has facilitated the development of collaborative groups of health and development initiatives called ‘Clusters’ in several countries including India, Bangladesh, Kenya, Tanzania, Zambia and Myanmar. In March 2016 these Clusters met together in an International Forum, to share learnings, experiences, challenges, achievements and to encourage one another. Discussions held throughout the forum suggest that the CHGN model is helping to promote effective, sustainable development and health care provision on both a local and a global scale.

University Students and Sustainability Skills in Occupational Health and Safety Master Degree

Science.gov (United States)

Míguez-Álvarez, Carla; Arce, Maria Elena; Souto-Gestal, Antonio

2016-01-01

Education is one of the key instruments to achieving global sustainability. In fact, sustainable development has to be integrated into higher education curricula. One of the difficulties of this challenge is to know if students are able to achieve the basic skills, something that is extremely important in emergency management. Thus, assessment of…

Sustainable recycling service- IKEA Espoo/Vantaa

OpenAIRE

Vlahakis, Lindell; Sapkota, Bishnu

2014-01-01

Sustainability has been an essential element in business operations over a decade due to the fact of rising concern for the environment; climate change, pollution, wildlife and forest, and social causes. Economic, social and environmental growth needed to be endeavored in order to achieve sustainable development. Corporate social responsibility (CSR) tends to enforce strategies of the company towards social and environmental responsibility. However, CSR is customarily limited to good governan...

A Systematic Review of Urban Sustainability Assessment Literature

Directory of Open Access Journals (Sweden)

Matthew Cohen

2017-11-01

Full Text Available As the world rapidly urbanizes, there is much focus on achieving sustainability outcomes within cities. Accomplishing this goal requires not only envisioning sustainable cities and implementing strategies, but it also demands assessing progress towards sustainable urban development. Despite a growing literature on sustainability assessment, there is room to further understand the application of sustainability assessment in urban contexts. This paper presents a systematic review of urban sustainability assessment literature to (1 identify the most common methods used for urban sustainability assessment, (2 identify the most common framings for urban sustainability assessment, and (3 identify the most common categories for organizing indicators that measure urban sustainability. This research finds that urban sustainability assessment in general lacks a unifying framing and that it could be better aligned with common sustainability principles. The paper provides recommendations for future urban sustainability assessment research, including the employment of mixed-methods research among other strategies. In closing, this research offers a generic framework around which to structure urban sustainability assessment and within which to assign indicators for measuring progress towards sustainable urban development.

Sustainability and sacred values

Directory of Open Access Journals (Sweden)

John Cairns Jr.

2002-09-01

Full Text Available Successful implementation of the quest for sustainable use of the planet requires that human society both reexamine and expand present views of what is sacred and what is not. The most important aspect will be going beyond a homocentric focus to a biocentric emphasis. A unifying theme would be the desire to leave a habitable planet for human descendants and those of other species. It is unlikely that society can be confident of achieving sustainability until persuasive evidence supporting this belief has existed for several generations. In order for sustainable use of the planet to persist indefinitely, the conditions essential to this state must be morally preserved on sacred grounds. Viewing natural systems as sacred requires not only preventing damage to them but, wherever possible, repairing damage to them caused by humankind.

Using the Sustainability Monitoring and Assessment Routine (SMART for the Systematic Analysis of Trade-Offs and Synergies between Sustainability Dimensions and Themes at Farm Level

Directory of Open Access Journals (Sweden)

Christian Schader

2016-03-01

Full Text Available When trying to optimize the sustainability performance of farms and farming systems, a consideration of trade-offs and synergies between different themes and dimensions is required. The aim of this paper is to perform a systematic analysis of trade-offs and synergies across all dimensions and themes. To achieve this aim we used the Sustainability Monitoring and Assessment Routine (SMART-Farm Tool which operationalizes the Sustainability Assessment of Food and Agriculture Systems (SAFA Guidelines by defining science-based indicator sets and assessment procedures. It identifies the degree of goal achievement with respect to the 58 themes defined in the SAFA Guidelines using an impact matrix that defines 327 indicators and 1769 relations between sustainability themes and indicators. We illustrate how the SMART-Farm Tool can be successfully applied to assess the sustainability performance of farms of different types and in different geographic regions. Our analysis revealed important synergies between themes within a sustainability dimension and across dimensions. We found major trade-offs within the environmental dimension and between the environmental and economic dimension. The trade-offs within the environmental dimension were even larger than the trade-offs with other dimensions. The study also underlines the importance of the governance dimension with regard to achieving a good level of performance in the other dimensions.

Approaches to Sustainable Development in Poland

International Nuclear Information System (INIS)

Kostrzewa, Karina; ); Piasecki, Ryszard

2009-01-01

The sustainable development principle was introduced into the legal system of Poland when the Constitution of the Polish Republic was adopted in 1997. Paradoxically, in Poland - one of the few countries in the world which have introduced the concept of sustainable development at the level of the Constitution, it is difficult to find a reference to it in the political debate. The national sustainable development strategy Poland 2025 has met no response among society and today it seems to be hardly remembered by anybody. An average citizen does not know the concept of sustainable development, or has a vague notion of it, often identifying it exclusively with environmental protection. Solving social problems (the labour market, education, health protection, equality of the sexes, etc.) is not associated with sustainable development whatsoever, and neither is engagement into achieving these development targets on the global scale

Annual Sustainability Report FY2015

Energy Technology Data Exchange (ETDEWEB)

2016-08-01

NREL's Sustainability Program is responsible for upholding all executive orders, federal regulations, U.S. Department of Energy (DOE) orders, and goals related to sustainable and resilient facility operations. But NREL continues to expand sustainable practices above and beyond the laboratory's regulations and requirements to ensure that the laboratory fulfills its mission into the future, leaves the smallest possible legacy footprint, and models sustainable operations and behaviors on national, regional, and local levels. The report, per the GRI reporting format, elaborates on multi-year goals relative to executive orders, achievements, and challenges; and success stories provide specific examples. A section called 'NREL's Resiliency is Taking Many Forms' provides insight into how NREL is drawing on its deep knowledge of renewable energy and energy efficiency to help mitigate or avoid climate change impacts.

Sustainable urban environmental quality

Directory of Open Access Journals (Sweden)

Tošković Dobrivoje

2004-01-01

Full Text Available MEANING as the essential element of urban quality. The role of the three main factors for the urban quality achievement: PLANNING, DEVELOPMENT and PEOPLE. Next to that, it is important to assume the identity of the local CONTEXT as the essential base for designing and shaping of form development. The problems of the quality achievements in the situation of the permanent changes. In such an environment - the RENEWAL of the towns become the basic strategic orientation requiring - evaluation of the development policy instruments. On the road of changes there are PROBLEMS of a strategic nature which should be, firstly, defined and, then, solved before entering in the process of structuring and arrangement. One of these problems is NEW versus OLD. Transition to a new policy of urbanism relying, first of all, on the private investors and international funds of the local authorities - call for a NEW STRATEGY in urbanism, in the context of the sustainability of environment. The sustainability of quality and the categories of the influencing factors. The sustainability of quality as a twofold process of urban design. The quality of environment as an aesthetic phenomenon. The urban situation and environmental quality: feasibility of changes and effects; the environmental capacity as an indicator and quality determinant. The urban quality and international experience. The evaluation of our urban situation. INSTEAD OF CONCLUSION: A general review on the visions and urban quality policy and planning. Toward an evaluation of urban environmental quality: negative and positive indicators; sustainable communities environmental ruling and urban quality planning.

Determinants of Sustainability and Organisational Effectiveness in Non-Profit Organisations

Directory of Open Access Journals (Sweden)

Chux Gervase Iwu

2015-07-01

Full Text Available This case study investigates the criteria for organizational effectiveness in non-profit organizations (NPOs with the aim to determine how the elements of sustainability fit within the criteria. To achieve this, the study utilized the research questions: “what criteria do NPOs use to evaluate their effectiveness?” and “how is sustainability embedded in NPO effectiveness?” The research design was interpretivist, adopting focus group interviews to obtain data. Specifically, two focus group interviews were held with the top management of an NPO which revealed that both financial and non-financial criteria were equally essential for NPO effectiveness. This finding is consistent with the literature, although it contradicts the initial assumption of the study that NPO effectiveness was based more on non-financial criteria than financial criteria. The study also found that the effectiveness of an NPO should be viewed in two ways: firstly, “the full achievement of its mandate” and, secondly, “the ability to run business projects to cover cost.” It also emerged that both the ability to cover costs and the achievement of a mandate should be done in a sustainable manner (a sustainable manner is seen as one that is harmonious with the natural and the socio-political environment. The results of this paper present a practical case for the management of NPOs by reiterating that the full achievement of the NPO mandate and the successful running of social projects to generate funds for sustainability are key elements of effectiveness. Given the essential role that NPOs play in developing countries, this study has provided the foundation for more widespread enquiry into the sustainability and effectiveness of NPOs.

[Discussion on releasing price of Chinese patent medicine to market economy to achieve sustainable development].

Science.gov (United States)

Long, Xingchao; Huang, Luqi; Jiang, Erguo; Zhou, Yonghong; Xu, Yanfeng; Zheng, Shuhua; Ning, Xiaoling; Liu, Hongwei; Chen, Lin

2012-02-01

To analyze costs of the traditional Chinese medicine industry focusing on production costs. Data of 50 planted Chinese herbal medicines and 50 wild Chinese herbal medicines were summarized and analyzed to see the changes of price of Chinese herbal medicines. The derivative problems of limited price were analyzed by crude drug, quality of Chinese medicine and sustainable utilization of resource. The price of Chinese medicine shall be adapted to sustainable development of market economy.

Sustainability constraints on UK bioenergy development

International Nuclear Information System (INIS)

Thornley, Patricia; Upham, Paul; Tomei, Julia

2009-01-01

Use of bioenergy as a renewable resource is increasing in many parts of the world and can generate significant environmental, economic and social benefits if managed with due regard to sustainability constraints. This work reviews the environmental, social and economic constraints on key feedstocks for UK heat, power and transport fuel. Key sustainability constraints include greenhouse gas savings achieved for different fuels, land availability, air quality impacts and facility siting. Applying those constraints, we estimate that existing technologies would facilitate a sustainability constrained level of medium-term bioenergy/biofuel supply to the UK of 4.9% of total energy demand, broken down into 4.3% of heat demands, 4.3% of electricity, and 5.8% of transport fuel. This suggests that attempts to increase the supply above these levels could have counterproductive sustainability impacts in the absence of compensating technology developments or identification of additional resources. The barriers that currently prevent this level of supply being achieved have been analysed and classified. This suggests that the biggest policy impacts would be in stimulating the market for heat demand in rural areas, supporting feedstock prices in a manner that incentivised efficient use/maximum greenhouse gas savings and targeting investment capital that improves yield and reduces land-take.

Ecosystem services for meeting sustainable development goals: Challenges and pathways

Directory of Open Access Journals (Sweden)

Huq Nazmul

2015-01-01

Full Text Available The paper summarizes four presentations of the session “Environment and Wellbeing: The Role of Ecosystems for Sustainable Development” at the international conference “Sustainability in the Water- Energy-Food Nexus” held on 19-20th May 2014 in Bonn, Germany. The aim of the session was to present current stresses on ecosystem services imposed by global development trajectory, potential impacts on Sustainable Development Goals (SDGs and pathways to achieve SDGs. All four presentations agreed that global ecosystem services are under increasing pressure from degradation and may not be able to meet the growing Water-Energy- Food (WEF demands especially for the developing world. Three examples from Tanzania, Cambodia and Niger made attempt to understand how governance policies attributed to natural resource depletion such as forestry and common grazing. The examples showed that governance policies favoring economic development are heavily contributing to clearing up natural resource bases. As a result, there were increasing conflicts among different resource user groups. Two other presentations introduce conceptual pathways to achieve the targets of Sustainable Development Goals (SDGs under current resource stressed regime. The pathways suggested global technologies, decentralized solutions and consumption changes as the major means of achieving global sustainability and poverty eradication without any major trade-offs.

Ecosystem services for meeting sustainable development goals: Challenges and pathways

Directory of Open Access Journals (Sweden)

Huq Nazmul

2015-01-01

Full Text Available The paper summarizes four presentations of the session “Environment and Wellbeing: The Role of Ecosystems for Sustainable Development” at the international conference “Sustainability in the Water- Energy-Food Nexus” held on 19-20th May 2014 in Bonn, Germany. The aim of the session was to present current stresses on ecosystem services imposed by global development trajectory, potential impacts on future Sustainable Development Goals (SDGs and pathways to achieve SDGs. All four presentations agreed that global ecosystem services are under increasing pressure from degradation and may not be able to meet the growing Water-Energy-Food (WEF demands especially for the developing world. Three examples from Tanzania, Cambodia and Niger made attempt to understand how government policies attributed to natural resource depletion such as forestry and common grazing. The examples showed that institutional policies favoring economic development contributing heavily to clearing up natural resource bases. As a result, there were increasing conflicts among different resource user groups. Two other presentations introduce conceptual pathways to achieve the targets of Sustainable Development Goals (SDGs under current resource stressed regime. The pathways suggested global technologies, decentralized solutions and consumption changes as the major means of achieving global sustainability and poverty eradication without any major trade-offs.

The road to sustainability

Energy Technology Data Exchange (ETDEWEB)

Sarrao, John L [Los Alamos National Laboratory; Crabtree, George [ANL

2009-01-01

Sustainability is the hottest topic in energy research today, but what does it actually mean? George Crabtree and John Sarrao describe what makes a technology sustainable, and outline the materials-science challenges standing between us and clean, long-lasting energy. Although most people agree that more-sustainable energy technologies are desirable, they often find it harder to agree on exactly how sustainable these technologies need to be, and even precisely what is meant by sustainability. To clarify the debate, we suggest three criteria for sustainability, each of which captures a different feature of the problem. While we do not have the lUxury of achieving full sustainability for all of our next-generation energy technologies, we can use these definitions to select our strategic sustainability targets and track our progress toward achieving them. As will become clear, the most sustainable energy technologies require the most challenging fundamental science breakthroughs. The first criterion for sustainability is 'lasts a long time'. This quality has been a feature of many energy sources we have used historically, including wood in ancient times and oil throughout most of the 20th century. The definition of 'long time' is, of course, relative: the world's demand for energy long ago outpaced the ability of wood to supply it, and the production of oil is likely to peak sometime within the next few decades. Substantial reductions in the rate of oil consumption through higher-efficiency processes can significantly impact on how long non-renewable resources last. In applying the 'long time' criterion, we need to distinguish between energy sources that are effectively limitless and those that are finite but, for the moment, adequate. The second criterion for sustainability is 'does no harm'. Burning fossil fuels releases pollutants such as sulphur and mercury that endanger human health, as well as greenhouse gases like

Perspectives on using prescribed fire to achieve desired ecosystem conditions

Science.gov (United States)

James M. Vose

2000-01-01

Fire is a potentially powerful tool for achieving desired conditions of forest ecosystems. From an ecological perspective, the use of fire requires affirmative answers to either of the following questions: (1) does it increase ecosystem health and sustainability? and (2) does it preserve or restore unique species or habitats? Health and sustainability can be measured...

ACHIEVING AND SUSTAINING STEADY-STATE ADVANCED TOKAMAK CONDITIONS ON DIII-D

International Nuclear Information System (INIS)

WADE, MR; MURAKAMI, M; BRENNAN, DP; CASPER, TA; FERRON, JR; GAROFALO, AM; GREENFIELD, CM; HYATT, AW; JAYAKUMAR, R; KINSEY, JE; LAHAYE, RJ; LAO, LL; LAZARUS, EA; LOHR, J; LUCE, TC; PETTY, CC; POLITZER, PA; PRATER, R; STRAIT, EJ; TURNBULL, AD; WATKINS, JG; WEST, WP

2002-01-01

Recent experiments on the DIII-D tokamak have demonstrated the feasibility of sustaining advanced tokamak conditions that combine high fusion power density (β > 4%), high bootstrap current fraction (f BS ∼ 65%), and high non-inductive current fractions (f NI ∼ 85%) for several energy confinement times. The duration of such conditions is limited only by resistive relaxation of the current density profile. Modeling studies indicate that the application of off-axis ECCD will be able to maintain a favorable current density profile for several seconds

Achieving and sustaining steady-state advanced tokamak conditions on DIII-D

International Nuclear Information System (INIS)

Wade, M.R.; Murakami, M.; Brennan, D.P.

2003-01-01

Recent experiments on the DIII-D tokamak have demonstrated the feasibility of sustaining advanced tokamak conditions that combine high fusion power density (β > 4%), high bootstrap current fraction (f BS ∼ 65%), and high non-inductive current fractions (f NI ∼85%) for several energy confinement times. The duration of such conditions is limited only by resistive relaxation of the current density profile. Modeling studies indicate that the application of off-axis ECCD will be able to maintain a favorable current density profile for several seconds. (author)

2000 Pilot Environmental Sustainability Index (ESI)

Data.gov (United States)

National Aeronautics and Space Administration — The 2000 Pilot Environmental Sustainability Index (ESI) is an exploratory effort to construct an index that measures the ability of a nation's economy to achieve...

Sustainable Urban Transport in the Developing World : Beyond Megacities

NARCIS (Netherlands)

Pojani, D.; Stead, D.

2015-01-01

Megacities have frequently received a disproportionate amount of attention over other sizes of cities in recent discourse on urban sustainability. In this article, the authors argue that a focus on smaller and medium-sized cities is crucial to achieving substantial progress towards more sustainable

Community capacity building and sustainability: outcomes of community-based participatory research.

Science.gov (United States)

Hacker, Karen; Tendulkar, Shalini A; Rideout, Catlin; Bhuiya, Nazmim; Trinh-Shevrin, Chau; Savage, Clara P; Grullon, Milagro; Strelnick, Hal; Leung, Carolyn; DiGirolamo, Ann

2012-01-01

For communities, the value of community-based participatory research (CBPR) is often manifested in the outcomes of increased capacity and sustainable adoption of evidence-based practices for social change. Educational opportunities that promote discourse between community and academic partners can help to advance CBPR and better define these outcomes. This paper describes a community-academic conference to develop shared definitions of community capacity building and sustainability related to CBPR and to identify obstacles and facilitators to both. "Taking It to the Curbside: Engaging Communities to Create Sustainable Change for Health" was planned by five Clinical Translational Science Institutes and four community organizations. After a keynote presentation, breakout groups of community and academic members met to define community capacity building and sustainability, and to identify facilitators and barriers to achieving both. Groups were facilitated by researcher-community partner teams and conversations were recorded and transcribed. Qualitative analysis for thematic content was conducted by a subset of the planning committee. Important findings included learning that (1) the concepts of capacity and sustainability were considered interconnected; (2) partnership was perceived as both a facilitator and an outcome of CBPR; (3) sustainability was linked to "transfer of knowledge" from one generation to another within a community; and (4) capacity and sustainability were enhanced when goals were shared and health outcomes were achieved. Community capacity building and sustainability are key outcomes of CBPR for communities. Co-learning opportunities that engage and mutually educate both community members and academics can be useful strategies for identifying meaningful strategies to achieve these outcomes.

Assessing Sustainability in Environmental Management: A Case Study in Malaysia Industry

Science.gov (United States)

Turan, Faiz Mohd; Johan, Kartina; Lanang, Wan Nurul Syahirah Wan; Asmanizam, Asmadianatasha

2017-08-01

The scarcity in measuring the sustainability accomplishment has been restrained most of the companies in Malaysian industry. Currently, there are variety types of the measurement tools of the sustainability assessment that have been implemented. However, there are still not achieving the inclusive elements required by the worldwide claim. In fact, the contribution to the sustainability performance are only highlighted on the nature, financial along with society components. In addition, some of the companies are conducting their sustainability implementation individually. By means, this process approaching type is needed to be integrated into a systematic system approach. This paper is focussing on investigating the present sustainability tools in the environmental management system for Malaysian industry prior to the quantification of the sustainability parameters. Hence, the parameters of the sustainability have been evaluated then in order to accomplish this project. By reviewing on the methodology of this research it comprises of three phases where it starts with the analyzation of the parameters in environmental management system according to the Malaysian context of industry. Moving on to the next step is the quantification of the criterion and finally the normalisation process will be done to determine the results of this research either it is succeeded or vice versa. As a result, this research has come to the conclusion where the level of the sustainability compliance does not achieve the standard level of the targeted objectives though it has already surpassed the average level of the sustainability performance. In future, the understanding towards the sustainability assessment is acquired to be aligned unitedly in order to integrated the process approach into the systematic approach. Apart, this research will be able to help to provide a measurable framework yet finally bestowing the Malaysian industry with a continuous improvement roadmap in achieving

Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: An Overview

Directory of Open Access Journals (Sweden)

Kai-Hsin Chang

2011-01-01

Full Text Available Because of the imbalance in the supply and demand of red blood cells (RBCs, especially for alloimmunized patients or patients with rare blood phenotypes, extensive research has been done to generate therapeutic quantities of mature RBCs from hematopoietic stem cells of various sources, such as bone marrow, peripheral blood, and cord blood. Since human embryonic stem cells (hESCs and induced pluripotent stem cells (iPSCs can be maintained indefinitely in vitro, they represent potentially inexhaustible sources of donor-free RBCs. In contrast to other ex vivo stem-cell-derived cellular therapeutics, tumorigenesis is not a concern, as RBCs can be irradiated without marked adverse effects on in vivo function. Here, we provide a comprehensive review of the recent publications relevant to the generation and characterization of hESC- and iPSC-derived erythroid cells and discuss challenges to be met before the eventual realization of clinical usage of these cells.

Learning from Sustainable Development: Education in the Light of Public Issues

Science.gov (United States)

Van Poeck, Katrien; Vandenabeele, Joke

2012-01-01

Education for sustainable development plays an increasing role in environmental education policy and practice. In this article, we show how sustainable development is mainly seen as a goal that can be achieved by applying the proper processes of learning and how this learning perspective translates sustainability issues into learning problems of…

Intelligent decision support systems for sustainable computing paradigms and applications

CERN Document Server

Abraham, Ajith; Siarry, Patrick; Sheng, Michael

2017-01-01

This unique book dicusses the latest research, innovative ideas, challenges and computational intelligence (CI) solutions in sustainable computing. It presents novel, in-depth fundamental research on achieving a sustainable lifestyle for society, either from a methodological or from an application perspective. Sustainable computing has expanded to become a significant research area covering the fields of computer science and engineering, electrical engineering and other engineering disciplines, and there has been an increase in the amount of literature on aspects sustainable computing such as energy efficiency and natural resources conservation that emphasizes the role of ICT (information and communications technology) in achieving system design and operation objectives. The energy impact/design of more efficient IT infrastructures is a key challenge in realizing new computing paradigms. The book explores the uses of computational intelligence (CI) techniques for intelligent decision support that can be explo...

Factors associated with sustained remission in patients with rheumatoid arthritis.

Science.gov (United States)

Martire, María Victoria; Marino Claverie, Lucila; Duarte, Vanesa; Secco, Anastasia; Mammani, Marta

2015-01-01

To find out the factors that are associated with sustained remission measured by DAS28 and boolean ACR EULAR 2011 criteria at the time of diagnosis of rheumatoid arthritis. Medical records of patients with rheumatoid arthritis in sustained remission according to DAS28 were reviewed. They were compared with patients who did not achieved values of DAS28<2.6 in any visit during the first 3 years after diagnosis. We also evaluated if patients achieved the boolean ACR/EULAR criteria. Variables analyzed: sex, age, smoking, comorbidities, rheumatoid factor, anti-CCP, ESR, CRP, erosions, HAQ, DAS28, extra-articular manifestations, time to initiation of treatment, involvement of large joints, number of tender joints, number of swollen joints, pharmacological treatment. Forty five patients that achieved sustained remission were compared with 44 controls. The variables present at diagnosis that significantly were associated with remission by DAS28 were: lower values of DAS28, HAQ, ESR, NTJ, NSJ, negative CRP, absence of erosions, male sex and absence of involvement of large joints. Only 24.71% achieved the boolean criteria. The variables associated with sustained remission by these criteria were: lower values of DAS28, HAQ, ESR, number of tender joints and number of swollen joints, negative CRP and absence of erosions. The factors associated with sustained remission were the lower baseline disease activity, the low degree of functional disability and lower joint involvement. We consider it important to recognize these factors to optimize treatment. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

Incorporating sustainability into TxDOT's transportation decision making : summary of work performed, methods used, and results achieved.

Science.gov (United States)

2011-02-01

This report summarizes the work performed in Fiscal Year (FY) 2009 and 2010 under TxDOT : Implementation Project 5-5541-01 Regional Workshops on Sustainability Enhancement : Tool. TxDOT Research Project 0-5541, Developing Sustainable Tra...

Sustainability marketing: An emancipatory critical realist perspective

OpenAIRE

Thomas, Nicola

2017-01-01

Sustainability marketing largely focuses on consumer behaviour, organisational marketing strategies and macromarketing perspectives. These approaches are guided by either positivism or interpretivism to address the so-called ‘wicked problems’ that arise from a myriad of unsustainable practices. Yet despite significant achievements in understanding (un)sustainability, the field alongside other disciplines has failed to systematically deliver the social changes necessary to halt and reverse the...

Sustainability of biomass for cofiring

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-02-01

There are many items to include when considering the sustainability of biomass for cofiring, and some of them are hard to quantify. The focus of this report is on the greenhouse gas emission aspects of sustainability. The reduction of greenhouse gas emissions achieved by substituting biomass for coal depends on a number of factors such as the nature of the fossil fuel reference system, the source of the biomass, and how it is produced. Relevant issues in biomass production include the energy balance, the greenhouse gas balance, land use change, non-CO2 greenhouse gas emission from soils, changes to soil organic carbon, and the timing of emissions and removal of CO2 which relates to the scale of biomass production. Certification of sustainable biomass is slow to emerge at the national and international level, so various organisations are developing and using their own standards for sustainable production. The EU does not yet have sustainability standards for solid biomass, but the UK and Belgium have developed their own.

Ants as tools in sustainable agriculture

DEFF Research Database (Denmark)

Offenberg, Joachim

2015-01-01

1. With an expanding human population placing increasing pressure on the environment, agriculture needs sustainable production that can match conventional methods. Integrated pest management (IPM) is more sustainable, but not necessarily as efficient as conventional non-sustainable measures. 2...... in multiple crops. Their efficiency is comparable to chemical pesticides or higher, while at lower costs. They provide a rare example of documented efficient conservation biological control. 3. Weaver ants share beneficial traits with almost 13 000 other ant species and are unlikely to be unique...... of agricultural systems, this review emphasizes the potential of managing ants to achieve sustainable pest management solutions. The synthesis suggests future directions and may catalyse a research agenda on the utilization of ants, not only against arthropod pests, but also against weeds and plant diseases...

Digital Gaming and Sustainable Design

Directory of Open Access Journals (Sweden)

Shahin Vassigh

2012-10-01

Full Text Available The American building industry is one of the major consumers of energy. Buildings use 39% of thetotal energy consumed in the United States, significantly impacting national energy demand andcontributing to global warming. The vast majority of architectural practice in US leads to construction of buildings with a little concern to sustainability leading to environmental degradation. Although the bulk of architecture practice continues to produce unsustainable buildings, there is growing stream of exemplary models of sustainable design. Examining the success of suchpractices leads into two a two-folded finding; first that achieving sustainable design is closelylinked to “integrated Design”1 - a type of practice in which various disciplines involved in building design work together to achieve efficiency and other synergetic benefits. Second is that theadvances in computing and simulation algorithms are paving the way to achieve “integrateddesign”. These technologies are enabling the designers to collaborate, visualize, foresee, andmodify building performance with relatively high accuracy. They are increasing used to analyze complex systems to achieve streamlined structures, reduce dependence on mechanical systems, produce more effective construction processes, and reduce waste.If such practices were to become widespread, the architectural education needs to be restructured.The traditional American architectural curriculum that is based on a schism between“design” and “technology” is inherently in conflict with the principal of integration. Though largescalereform of architectural curricula is a complex, ongoing, and difficult debate; producing teaching tools that can simulate integrated design can impact and promote an understanding of sustainable practice in architecture. The proposed paper will present the progress of a multi-disciplinary team of faculty who arecollectively working on the completion, implementation and evaluation

The use of radiological guidelines to achieve a sustained reduction in the number of radiographic examinations of the cervical spine, lumbar spine and knees performed for GPs

International Nuclear Information System (INIS)

Glaves, J.

2005-01-01

AIM: To determine if the use of request guidelines can achieve a sustained reduction in the number of radiographic examinations of the cervical spine, lumbar spine and knee joints performed for general practitioners (GPs). METHODS: GPs referring to three community hospitals and a district general hospital were circulated with referral guidelines for radiography of the cervical spine, lumbar spine and knee, and all requests for these three examinations were checked. Requests that did not fit the guidelines were returned to the GP with an explanatory letter and a further copy of the guidelines. Where applicable, a large-joint replacement algorithm was also enclosed. If the GP maintained the opinion that the examination was indicated, she or he had the option of supplying further justifying information in writing or speaking to a consultant radiologist. RESULTS: Overall the number of radiographic examinations fell by 68% in the first year, achieving a 79% reduction in the second year. For knees, lumbar spine and cervical spine radiographs the total reductions were 77%, 78% and 86%, respectively. CONCLUSION: The use of referral guidelines, reinforced by request checking and clinical management algorithms, can produce a dramatic and sustained reduction in the number of radiographs of the cervical spine, lumbar spine and knees performed for GPs

Desired, Perceived, and Achieved Sustainability: Trade-Offs in Strategic and Operational Packaging Development

NARCIS (Netherlands)

de Koeijer, Bjorn; de Lange, Jos; Wever, Renee

2017-01-01

The alignment of the strategic and the operational level of packaging development in relation to the integration of sustainability is not addressed extensively in current research. This paper aims to address this, by focusing on the decision-making interrelations of key actors (marketing and

INSPIA project: European Index for Sustainable and Productive Agriculture

Science.gov (United States)

Triviño-Tarradas, Paula; Jesús González-Sánchez, Emilio; Gómez-Ariza, Manuel; Rass, Gerard; Gardette, Sophie; Whitmore, Gavin; Dyson, Jeremy

2017-04-01

The concept of sustainable development has evolved from a mere perception for the protection of the environment, to a holistic approach, seeking to preserve not only the environment, but also to achieve sustainability in economics and social wellbeing. Globally, there is a major challenge to face in the agricultural sector: to produce more food, feed and other raw materials to satisfy the increasing demand of a growing population, whilst also contributing to economic prosperity, climate change mitigation / adaptation, social wellbeing and preserving natural capital such as soil, water, biodiversity and other ecosystem services. Nowadays, conventional approaches to agriculture are under threat. A more productive and resource efficient agriculture that integrates natural resource protection into its approach will help to meet all these challenges, enabling us to have more of everything - more food, more feed, more non-food crops, more biodiversity and natural habitats - while also reducing greenhouse gas emissions. In this context, INSPIA is an innovative approach that has worked since 2013 towards demonstration that sustainable productive agriculture is possible thanks to the implementation of a host of best management practices (BMPs) capable of delivering the above achievements. The purpose on INSPIA is to make visible with European decision makers that a sustainable and productive agricultural model exists in a small scale in Europe and that wider dissemination is possible with enabling legislation. INSPIA is demonstrating sustainable agriculture through the implementation of BMPs and the measurement and monitoring of a set of defined indicators (economic, social and environmental ones). INSPIA promotes sustainable practices that protect biodiversity, soils and water and contribute towards maintaining ecosystems services. This holistic sustainable system of productive agriculture is based on the combination of Conservation Agriculture (CA) and Integrated Pest

The Integrated Scorecard in support of corporate sustainability strategies.

Science.gov (United States)

Journeault, Marc

2016-11-01

Organizations have increasingly recognized the importance and benefits of developing a sustainability strategy that incorporates environmental and social responsibilities. However, the simultaneous integration of the economic, environmental and social aspects remains a major concern for organizations. The Sustainability Balanced Scorecard (SBSC) represents one of the most promising strategic tools to help organizations face these challenges and support their sustainability strategy. However, past research has provided unclear, incomplete and even contradictory SBSC frameworks while offering little knowledge about how to integrate stakeholder management as well as environmental and social performance within the balanced scorecard to successfully support a corporate sustainability strategy. The aim of this study is to address these issues and limitations by proposing the Integrated Scorecard, a specific SBSC that integrates the three pillars of sustainability performance within four different perspectives, namely environmental, social and economic performance, stakeholder management, internal business processes, and skills and capabilities. This study provides a conceptual approach to the Integrated Scorecard and illustrates, through the use of two practical illustrations, the ability of this framework to support the corporate sustainability strategy by identifying the core sustainability objectives that organizations should achieve when creating value, facilitating the understanding of the contribution of environmental and social initiatives on economic performance, allowing the monitoring and measurement of the strategy's level of achievement, and creating synergy between sustainability performance management and reporting. Copyright © 2016 Elsevier Ltd. All rights reserved.

Sustainability in Electricity Markets. Study for the Dutch Transition Platform on Sustainable Electricity

International Nuclear Information System (INIS)

2005-12-01

The current energy system is not sustainable. This situation is liable to lead to serious and costly consequences in the long term. The two most important themes to be addressed are climate change and securing energy supplies, particularly in view of the increasing dependency on fossil fuels from geo-politically unstable regions. That is why the Dutch government has decided to strive for a transition towards a Sustainable Energy System. The aim of the energy transition is to transform the current energy system over the coming decades into a sustainable energy system. The participants in this Energy Transition have established six themes for achieving a sustainable energy economy within 50 years. Within these themes experiments are being conducted, experiments that ensure that the final aims become clearer and feasible. Market participants, scientific and civil organizations, and government agencies are taking the lead in each of the six themes: (a) Green raw materials; (b) Sustainable Mobility; (c) Chain Efficiency; (d) New Gas; (e) Sustainable Electricity; (f) Energy in the built environment. This document provides input for the theme on Sustainable Electricity. The Dutch Ministry of Economic Affairs together with SenterNovem is preparing a Platform Renewable Electricity Supply. In this Platform representatives from different stakeholders are to take part. The platform is meant to stimulate concrete actions/initiatives towards sustainable electricity supply. SenterNovem has asked PricewaterhouseCoopers (PwC) to make an international inventory of electricity market developments, with a focus on the impact for future sustainable electricity supply. The question which options for electricity generation are the most suitable for a sustainable electricity supply will be dealt with by KEMA (a Dutch research institute for the electric power industry)

Sustainability Report: National Renewable Energy Laboratory (NREL) 2003 -- 2004

Energy Technology Data Exchange (ETDEWEB)

2004-09-01

The National Renewable Energy Laboratory's (NREL) Sustainability Report for 2003-2004 highlights the Laboratory's comprehensive sustainability activities. These efforts demonstrate NREL's progress toward achieving overall sustainability goals. Sustainability is an inherent centerpiece of the Laboratory's work. NREL's mission--to develop renewable energy and energy efficiency technologies and practices and transfer knowledge and innovations to address the nation's energy and environmental goals--is synergistic with sustainability. The Laboratory formalized its sustainability activities in 2000, building on earlier ideas--this report summarizes the status of activities in water use, energy use, new construction, green power, transportation, recycling, environmentally preferable purchasing, greenhouse gas emissions, and environmental management.

Measuring sustainable accessibility potential using the mobility infrastructure's network configuration

NARCIS (Netherlands)

Gil, J.; Read, S.

2012-01-01

This paper is an exploration into the analysis of public transport networks using space syntax approaches combined with concepts of sustainable accessibility. Present urban development policy aims to achieve sustainable mobility patterns, shifting mobility to soft transportation modes such as

A Methodology for Sustainability Evaluation and Reporting in Higher Education Institutions

Science.gov (United States)

Madeira, Ana C.; Carravilla, Maria Antonia; Oliveira, Jose F.; Costa, Carlos A. V.

2011-01-01

The purpose of this paper is to present a methodology that allows higher education institutions (HEIs) to promote, to evaluate and to report on sustainability. The ultimate goal of the afore-mentioned methodology is to help HEIs achieve sustainability. First, a model entitled Sustainability in Higher Education Institutions (SusHEI) that generally…

Sustainable Development of Sewage Sludge-to-Energy in China

DEFF Research Database (Denmark)

Ren, Jingzheng; Liang, Hanwei; Dong, Liang

2017-01-01

) to identify the critical barriers that hinder the sustainable development of sludge-to-energy industry in China and to investigate the cause-effect relationships among these barriers. Accordingly, some policy implications for promoting the sustainable development of sludge-to-energy industry in China were......In order to promote the sustainable development of sludge-to-energy industry and help the decision-makers/stakeholders to select the most sustainable technology for achieving the sludge-to-energy target, this study aims at using grey Decision Making Trial and Evaluation Laboratory (DEMATEL...

Achievement goal profiles and developments in effort and achievement in upper elementary school.

Science.gov (United States)

Hornstra, Lisette; Majoor, Marieke; Peetsma, Thea

2017-12-01

The multiple goal perspective posits that certain combinations of achievement goals are more favourable than others in terms of educational outcomes. This study aimed to examine longitudinally whether students' achievement goal profiles and transitions between profiles are associated with developments in self-reported and teacher-rated effort and academic achievement in upper elementary school. Participants were 722 fifth-grade students and their teachers in fifth and sixth grade (N = 68). Students reported on their achievement goals and effort in language and mathematics three times in grade 5 to grade 6. Teachers rated students' general school effort. Achievement scores were obtained from school records. Goal profiles were derived with latent profile and transition analyses. Longitudinal multilevel analyses were conducted. Theoretically favourable goal profiles (high mastery and performance-approach goals, low on performance-avoidance goals), as well as transitions from less to more theoretically favourable goal profiles, were associated with higher levels and more growth in effort for language and mathematics and with stronger language achievement gains. Overall, these results provide support for the multiple goal perspective and show the sustained benefits of favourable goal profiles beyond effects of cognitive ability and background characteristics. © 2017 The Authors. British Journal of Education Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7

International Nuclear Information System (INIS)

Goupille, Olivier; Penglong, Tipparat; Lefèvre, Carine; Granger, Marine; Kadri, Zahra; Fucharoen, Suthat; Maouche-Chrétien, Leila; Leboulch, Philippe; Chrétien, Stany

2012-01-01

Highlights: ► UT7 erythroleukemia cells are known to be refractory to differentiate. ► Brief JQ1 treatment initiates the first steps of erythroid differentiation program. ► Engaged UT7 cells then maturate in the presence of erythropoietin. ► Sustained JQ1 treatment inhibits both proliferation and erythroid differentiation. -- Abstract: Malignant transformation is a multistep process requiring oncogenic activation, promoting cellular proliferation, frequently coupled to inhibition of terminal differentiation. Consequently, forcing the reengagement of terminal differentiation of transformed cells coupled or not with an inhibition of their proliferation is a putative therapeutic approach to counteracting tumorigenicity. UT7 is a human leukemic cell line able to grow in the presence of IL3, GM-CSF and Epo. This cell line has been widely used to study Epo-R/Epo signaling pathways but is a poor model for erythroid differentiation. We used the BET bromodomain inhibition drug JQ1 to target gene expression, including that of c-Myc. We have shown that only 2 days of JQ1 treatment was required to transitory inhibit Epo-induced UT7 proliferation and to restore terminal erythroid differentiation. This study highlights the importance of a cellular erythroid cycle break mediated by c-Myc inhibition before initiation of the erythropoiesis program and describes a new model for BET bromodomain inhibitor drug application.

BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7

Energy Technology Data Exchange (ETDEWEB)

Goupille, Olivier [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Penglong, Tipparat [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Thalassemia Research Center and Department of Clinical Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University (Thailand); Lefevre, Carine; Granger, Marine; Kadri, Zahra [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Fucharoen, Suthat [Thalassemia Research Center and Department of Clinical Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University (Thailand); Maouche-Chretien, Leila [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Leboulch, Philippe [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Genetics Division, Department of Medicine, Brigham and Women' s Hospital and Harvard Medical School, Boston, MA (United States); Chretien, Stany, E-mail: stany.chretien@cea.fr [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France)

2012-12-07

Highlights: Black-Right-Pointing-Pointer UT7 erythroleukemia cells are known to be refractory to differentiate. Black-Right-Pointing-Pointer Brief JQ1 treatment initiates the first steps of erythroid differentiation program. Black-Right-Pointing-Pointer Engaged UT7 cells then maturate in the presence of erythropoietin. Black-Right-Pointing-Pointer Sustained JQ1 treatment inhibits both proliferation and erythroid differentiation. -- Abstract: Malignant transformation is a multistep process requiring oncogenic activation, promoting cellular proliferation, frequently coupled to inhibition of terminal differentiation. Consequently, forcing the reengagement of terminal differentiation of transformed cells coupled or not with an inhibition of their proliferation is a putative therapeutic approach to counteracting tumorigenicity. UT7 is a human leukemic cell line able to grow in the presence of IL3, GM-CSF and Epo. This cell line has been widely used to study Epo-R/Epo signaling pathways but is a poor model for erythroid differentiation. We used the BET bromodomain inhibition drug JQ1 to target gene expression, including that of c-Myc. We have shown that only 2 days of JQ1 treatment was required to transitory inhibit Epo-induced UT7 proliferation and to restore terminal erythroid differentiation. This study highlights the importance of a cellular erythroid cycle break mediated by c-Myc inhibition before initiation of the erythropoiesis program and describes a new model for BET bromodomain inhibitor drug application.

Hemopoietic regeneration in murine spleen following transfusion of normal and irradiated marrow: different response of granulocyte/macrophage and erythroid precursors

International Nuclear Information System (INIS)

Wangenheim, K.-H. von; Peterson, H.-P.; Huebner, G.E.; Feinendegen, L.E.

1987-01-01

To investigate cell proliferation in regenerating spleen, bone marrow of normal and gamma-irradiated donor mice (3 weeks after 5 Gy) was transfused into lethally irradiated recipients. In the donors and in the recipient spleens numbers of CFU-S and progenitor cells were determined. In the irradiated donors the progenitors were at control level after 3 weeks of recovery although CFU-S were still at 50% of control. Recipients of the irradiated marrow received therefore an increased proportion of progenitors. CFU-C appeared to be self-renewing and/or increased in number due to enhanced CFU-S differentiation, but not the erythroid progenitors. CFU-S self-renewal was reduced after 5 Gy. The data suggest that cell differentiation and maturation proceed during early splenic regeneration. The quantity of CFU-C does not necessarily mirror the situation in the stem cell compartment. (author)

Sustainable development benefits of clean development mechanism projects

International Nuclear Information System (INIS)

Olsen, Karen Holm; Fenhann, Jorgen

2008-01-01

The clean development mechanism (CDM) is part of the global carbon market developing rapidly in response to global warming. It has the twin objective to achieve sustainable development (SD) in host countries and assist Annex-1 countries in achieving their emission reduction targets in a cost-efficient manner. However, research has shown that trade-offs between the two objectives exist in favour of cost-efficient emission reductions and that left to the market forces, the CDM does not significantly contribute to sustainable development. The main argument of the paper is the need for an international standard for sustainability assessment-additional to national definitions-to counter weaknesses in the existing system of sustainability approval by designated national authorities in host countries. The article develops a new methodology, i.e. a taxonomy for sustainability assessment based on text analysis of the 744 project design documents (PDDs) submitted for validation by 3 May 2006. Through analysis of the SD benefits of all CDM projects at aggregated levels, the strengths and limitations of the taxonomy are explored. The main policy implication of the research is to propose the taxonomy as the basis of an international verification protocol for designated operational entities (DOEs) for reporting, monitoring and verifying that potential SD benefits described in the PDDs are actually realized

Sustainability Base Construction Update

Science.gov (United States)

Mewhinney, Michael

2012-01-01

Construction of the new Sustainability Base Collaborative support facility, expected to become the highest performing building in the federal government continues at NASA's Ames Research Center, Moffet Field, Calif. The new building is designed to achieve a platinum rating under the leadership in Energy and Environment Design (LEED) new construction standards for environmentally sustainable construction developed by the U. S. Green Building Council, Washington, D. C. When completed by the end of 2011, the $20.6 million building will feature near zero net energy consumption, use 90 percent less potable water than conventionally build buildings of equivalent size, and will result in reduced building maintenance costs.

What is sustainability and what influences it?

Energy Technology Data Exchange (ETDEWEB)

Schock, R.N.

1997-06-04

I was asked to speak on the subject of ``What do we mean by sustainability and what factors have the most impact on it?`` I am afraid I must admit that if there is a generally accepted definition of sustainability, at least as applied to mankind and terrestrial systems, then I am not aware of it. But I expect you know that, or you would not be having this session. The subject of sustainability is one that interests us all. In fact, I think that it fascinates us all because the concept is one to which we can intimately relate. Sustainability implies eternal life; and throughout history, humankind has sought, sometimes secretly, sometimes openly, eternal life, if not for ourselves at least for our progeny. What I will try to do is (1) briefly discuss some of what has been said about this topic, (2) propose a definition that I believe is workable, and point out some of the issues that derive from it, and then (3) suggest what I think we can all do to ensure the sustainability of the planet. I confess to you at the outset that I am an optimist on this subject, and a technological optimist at that. By that I mean that I believe that humans and technology are inextricably linked and that technology provides one of the great keys to helping human beings achieve their goals. I also believe that sustainability is an achievable goal and that it is not a concept to be feared, either intrinsically or economically.

Sub-Saharan Africa: Sustainability Risk Discussion

Directory of Open Access Journals (Sweden)

Victoria Bakhtina

2011-11-01

Full Text Available Africa is a rising star - one of the most desirable investment destinations in the world. Nonetheless, economic growth is uneven among African countries, and many obstacles must be overcome in order to realize the full potential of opportunity. To achieve long-term sustainable investment results, and ultimately progress towards Sustainable Development goals, many risks must be isolated, analyzed, and mitigated. This paper introduces the concept of Sustainability Risk, identifying a set of major risk components for Sub-Saharan Africa and building an integral measure to quantify the degree of remoteness of the forty-six Sub-Saharan Africa countries from the total set of threats considered. The countries are separated into distinct groups with similar characteristics in terms of Sustainability Risk, and an analysis for potential decision-making, based on the visualization of the countries' position in relation to the major sustainability threats, is performed for each group. The research identifies risks with maximum impacts.

The next phase in professional services research: From implementation to sustainability.

Science.gov (United States)

Crespo-Gonzalez, Carmen; Garcia-Cardenas, Victoria; Benrimoj, Shalom I

The provision of professional pharmacy services has been heralded as the professional and the economic future of pharmacy. There are different phases involved in a service creation including service design, impact evaluation, implementation and sustainability. The two first phases have been subject to extensive research. In the last years the principles of Implementation science have been applied in pharmacy to study the initial uptake and integration of evidence-based services into routine practice. However, little attention has been paid to the sustainability of those services, during which there is a continued use of the service previously implemented to achieve and sustain long-term outcomes. The objective of this commentary is to describe the differences and common characteristics between the implementation and the sustainability phase and to propose a definition for pharmacy. A literature search was performed. Four critical elements were identified: 1. The aim of the implementation phase is to incorporate new services into practice, the sustainability phase's aim is to make the services routine to achieve and sustain long-term benefits 2. At the implementation phase planned activities are used as a process to integrate the new service, at the sustainability phase there is a continuous improvement of the service 3. The implementation phase occurs during the period of time between the adoption of a service and its integration. Some authors suggest the sustainability phase is a concomitant phase with the implementation phase and others suggest it is independent 4. There is a lack of consensus regarding the duration of each phase. The following definition of sustainability for pharmacy services is proposed: "Sustainability is a phase in the process of a professional pharmacy service, in which the service previously integrated into practice during the implementation phase is routinized and institutionalized over time to achieve and sustain the expected service

Development of Sustainability Assessment Tool for Malaysian hydropower industry: A case study

Science.gov (United States)

Turan, Faiz Mohd; Johan, Kartina; Abu Sofian, Muhammad Irfan

2018-04-01

This research deals with the development of sustainability assessment tools as a medium to assess the performance of a hydropower project compliances towards sustainability practice. Since the increasing needs of implementing sustainability practice, developed countries are utilizing sustainability tools to achieve sustainable development goals. Its inception within ASEAN countries including Malaysia is still low. The problem with most tools developed from other countries is that it is not very comprehensive as well as its implementation factors are not suitable for the local environment that is not quantified. Hence, there is a need to develop a suitable sustainable assessment tool for the Malaysian hydropower industry to comply with the sustainable development goals as a bridging gap between the governor and the practitioner. The steps of achieving this goal is separated into several parts. The first part is to identify sustainable parameters from established tools as a model for comparison to enhance new parameters. The second stage is to convert equivalent quantification value from the model to the new developed tools. The last stage is to develop software program as a mean of gaining energy company feedback with systematic sustainable reporting from the surveyor so as to be able to integrate sustainability assessment, monitoring and reporting for self-improved reporting.

NATURAL RESOURCES AVAILABILITY IN A SUSTAINABLE ECONOMY

Directory of Open Access Journals (Sweden)

CĂTĂLINA BONCIU

2013-05-01

Full Text Available In the theoretical and practical approach of the economic life, appears more often the idea of sustainable economic development, of reconciliation between man and nature in attracting and using its resources without interfering in its natural movement and evolution. In this paper we are trying to bring to light the relation between the economic development and the mineral resources, in terms of achieving sustainable development. The place and role of natural factors in the market economy is revealed by bringing to the forefront a number of arguments that demonstrate their vital position in the sustainable growth and development.

The first trimester human placenta is a site for terminal maturation of primitive erythroid cells.

Science.gov (United States)

Van Handel, Ben; Prashad, Sacha L; Hassanzadeh-Kiabi, Nargess; Huang, Andy; Magnusson, Mattias; Atanassova, Boriana; Chen, Angela; Hamalainen, Eija I; Mikkola, Hanna K A

2010-10-28

Embryonic hematopoiesis starts via the generation of primitive red blood cells (RBCs) that satisfy the embryo's immediate oxygen needs. Although primitive RBCs were thought to retain their nuclei, recent studies have shown that primitive RBCs in mice enucleate in the fetal liver. It has been unknown whether human primitive RBCs enucleate, and what hematopoietic site might support this process. Our data indicate that the terminal maturation and enucleation of human primitive RBCs occurs in first trimester placental villi. Extravascular ζ-globin(+) primitive erythroid cells were found in placental villi between 5-7 weeks of development, at which time the frequency of enucleated RBCs was higher in the villous stroma than in circulation. RBC enucleation was further evidenced by the presence of primitive reticulocytes and pyrenocytes (ejected RBC nuclei) in the placenta. Extravascular RBCs were found to associate with placental macrophages, which contained ingested nuclei. Clonogenic macrophage progenitors of fetal origin were present in the chorionic plate of the placenta before the onset of fetoplacental circulation, after which macrophages had migrated to the villi. These findings indicate that placental macrophages may assist the enucleation process of primitive RBCs in placental villi, implying an unexpectedly broad role for the placenta in embryonic hematopoiesis.

Utilising the Potential of Design Briefs in Sustainable Packaging Development

OpenAIRE

ten Klooster, Roland; de Koeijer, Bjorn

2016-01-01

Sustainable considerations in the development of product-packaging combinations require activities on both the strategic and operational level. As part of a company’s vision, the strategic level of development targets the desired implementation of sustainability considerations. The activities of the multidisciplinary teams of marketers, designers and engineers, which specifies the achieved sustainability in finished packaging concepts, largely determines the operational level of product-packa...

Towards sustainability in offshore oil and gas operations

Science.gov (United States)

Khan, M. Ibrahim

acceptable, economically profitable and socially responsible. This dissertation discusses the framework of true 'sustainability' for practically all aspects oil and gas operations and nature-based resource operations. Sustainability of existing offshore oil and gas operations techniques are analyzed and new nature-based technologies are proposed. Also evaluated are the fate and effect, environmental impact, risk factors, and the green supply chain in the case of seismic, drilling, production and decommissioning of oil operations. It is demonstrated with detailed examples that using the new approach will be economically more beneficial than the conventional approach, even in the short-term. The dissertation also examines the present status of petroleum operations with respect to waste generation, improper resource management, and the usage of toxic compounds in the overall lifecycle. To achieve true sustainability, some innovative models and technologies are presented. They include achievement of zero emissions, zero waste of resources, zero waste in activities, zero use of toxics, and zero waste in product life-cycle. This dissertation also discusses the environmental and technological problems of the petroleum sector and provides guidelines to achieve overall sustainability in oil company activities. Finally, this dissertation shows that inherent sustainability can be achieved by the involvement of community participation. The new screening tool proposed in this dissertation provides proper guidelines to achieve true sustainability in the technology development and other resource development operations.

Progress towards sustainable development : 1997 sustainable development report

International Nuclear Information System (INIS)

1998-01-01

The ways in which Shell Canada has been able to incorporate sustainable development concepts into the Company's business strategies were highlighted. The report describes Shell Canada's plans for protecting the air, water, wilderness, wildlife, soil and groundwater. Land reclamation of abandoned well sites, building a solid capability in emergency preparedness and a strong program to ensure health and safety, are also high on Shell Canada's priorities list. Achievements in 1997, led by the completion of environmental and socio-economic impact assessment of the Sable Offshore Energy Project and the announcement of plans for the construction of a mine and extraction plant north of Fort McMurray (Musked River Mine) Alberta, were reviewed. An ambitious list of objectives and targets for 1998 were also outlined. While in 1997 improvements in safety and sustainable development performance were impressive, financial results were also gratifying, with the Company reporting its best financial results ever. tabs., figs

Multiple helix ecosystems for sustainable competitiveness

CERN Document Server

Ferreira, João; Farinha, Luís; Fernandes, Nuno

2016-01-01

This book discusses the main issues, challenges, opportunities, and trends involving the interactions between academia, industry, government and society. Specifically, it aims to explore how these interactions enhance the ways in which companies deliver products and services in order to achieve sustainable competitiveness in the marketplace. Sustainable competitiveness has been widely discussed by academics and practitioners, considering the importance of protecting the environment while sustaining the economic goals of organizations. The Quintuple Helix innovation model is a framework for facilitating knowledge, innovation and sustainable competitive advantage. It embeds the Triple and the Quadruple Helix models by adding a fifth helix, the “natural environment.” The Triple Helix model focuses on the university-industry-government triad, while the Quadruple adds civil society (the media- and culture-driven public) as a fourth helix. The Quintuple Helix model facilitates research, public policy, and pract...

Networks as Tools for Urban Sustainability

DEFF Research Database (Denmark)

Jensen, Jesper Ole; Tollin, Nicola

2004-01-01

Due to the increasing number of networks related to sustainable development (SUD) the paper focuses on understanding in which way networks can be considered useful tools for sustainable urban development, taking particularly into consideration the networks potential of spreading innovative policies...... will be discussed through a case study of a Danish municipal network on Sustainable Development, Dogme 2000 . This network has become quite successful in terms of learning and innovation, committing actors, and influencing local policies, to a larger extent than other SUD-networks the municipalities are involved in....... By applying the GREMI -theories of “innovative milieux” (Aydalot, 1986; Camagni, 1991) to the case study, we will suggest some reasons for the benefits achieved by the Dogme-network, compared to other networks. This analysis will point to the existence of an “innovative milieu” on sustainability within...

Energy and sustainable development: issues and options

International Nuclear Information System (INIS)

Appert, O.

2001-01-01

Future development needs to be sustainable in all of its dimensions if it is to continue to fully contribute to human welfare. In the achievement of this objective, the manner in which energy is produced and consumed is of crucial importance. In the wake of these insights, first attempts begin to provide concrete options for steps towards sustainability in the energy sector. Two criteria can be identified for developing sustainable development policies. First, such policies need to strike a balance between the three dimensions of sustainable development - economic, environmental and social - acknowledging that all three are intrinsically linked. Second, policies in the energy sector need to reduce exposure to large-scale risks and improve the resilience of the energy system through active risk management and diversification. (authors)

Achieving equilibrium status and sustainable landfill - the holy grail?

OpenAIRE

Hall, D. H.; Gronow, Jan R.; Smith, Richard; Blakey, N.

2004-01-01

This paper presents the results of a research contract jointly funded by the Environment Agency and ESART examining the residues of likely post-Landfill Directive waste streams that will need to go to landfill and the time taken to achieve sufficient stabilisation such that management controls can be removed. The first part of the project has identified a number of processes that are likely to be adopted by the waste management industry in order to meet the biodegradable waste ...

Corporate sustainability: environmental, social, economic and corporate performance

Directory of Open Access Journals (Sweden)

Alena Kocmanová

2011-01-01

Full Text Available The article deals with corporate sustainability and environmental and social issues of the integration of corporate performance measurement that may lead to sustainable economic success. Sustainability is a strategy of the process of sustainable development. Sustainability of businesses and sustainable performance can be defined as an integration of environmental, social and economic performance. First and foremost, businesses will want to know what indicators can be used to measure environmental, social and economic performance. What is the mutual relationship between environmental, social and economic performance? How can firms arrive at a comprehensive assessment of their performance in relation to sustainability? The aim of this paper is to analyze corporate environmental, social and economic performance and to analyze their mutual relationships. The final part of the article is an assessment of the contemporary situation and draft Key Performance Indicators (KPI for assessment of corporate sustainability that will be the subject of further research in a selected NACE-CZ sector and in accordance with Corporate Sustainability Reporting. KPI provide businesses with a means of measuring progress toward achieving objectives.

The relationship between settlement population size and sustainable development measured by two sustainability metrics

International Nuclear Information System (INIS)

O'Regan, Bernadette; Morrissey, John; Foley, Walter; Moles, Richard

2009-01-01

This paper reports on a study of the relative sustainability of 79 Irish villages, towns and a small city (collectively called 'settlements') classified by population size. Quantitative data on more than 300 economic, social and environmental attributes of each settlement were assembled into a database. Two aggregated metrics were selected to model the relative sustainability of settlements: Ecological Footprint (EF) and Sustainable Development Index (SDI). Subsequently these were aggregated to create a single Combined Sustainable Development Index. Creation of this database meant that metric calculations did not rely on proxies, and were therefore considered to be robust. Methods employed provided values for indicators at various stages of the aggregation process. This allowed both the first reported empirical analysis of the relationship between settlement sustainability and population size, and the elucidation of information provided at different stages of aggregation. At the highest level of aggregation, settlement sustainability increased with population size, but important differences amongst individual settlements were masked by aggregation. EF and SDI metrics ranked settlements in differing orders of relative sustainability. Aggregation of indicators to provide Ecological Footprint values was found to be especially problematic, and this metric was inadequately sensitive to distinguish amongst the relative sustainability achieved by all settlements. Many authors have argued that, for policy makers to be able to inform planning decisions using sustainability indicators, it is necessary that they adopt a toolkit of aggregated indicators. Here it is argued that to interpret correctly each aggregated metric value, policy makers also require a hierarchy of disaggregated component indicator values, each explained fully. Possible implications for urban planning are briefly reviewed

The Future We Want: Key Issues on Sustainable Development in Higher Education after Rio and the UN Decade of Education for Sustainable Development

Science.gov (United States)

Leal Filho, Walter; Manolas, Evangelos; Pace, Paul

2015-01-01

Purpose: This paper aims to provide a description of the achievements of the United Nations (UN) Decade of Education for Sustainable Development (2005-2014) with a focus on higher education, and it describes some of the key issues which will guide sustainable development in the coming years. Design/methodology/approach: The paper initially…

Optimal fiscal policy rule for achieving fiscal sustainability: A Japanese case study

OpenAIRE

Yoshino, Naoyuki; Mizoguchi, Tetsuro; Taghizadeh-Hesary, Farhad

2015-01-01

Japan's debt-to-gross domestic product (GDP) ratio is the highest among Organisation for Economic Co-operation and Development (OECD) countries. This paper will firstly answer the question of whether Japanese government debt is sustainable. Next, while the Domar condition and Bohn's condition are often used in the literature to check whether a government's debt situation is in a dangerous zone, this paper will show that the Domar condition is obtained only from the government budget constrain...

Urban Sustainability through Public Architecture

Directory of Open Access Journals (Sweden)

Soomi Kim

2018-04-01

Full Text Available As the sustainability of contemporary cities has gained emphasis, interest in architecture has increased, due to its social and public responsibility. Since sustainability is linked to public values, research on sustainable public spaces is an important way to secure sustainability in cities. Based on this, we analyzed the sustainability of European cities by examining the design methods of public architecture according to the region. The aim of the study is to derive architectural methodology corresponding to local characteristics, and to suggest issues to consider in public architecture design to promote urban sustainability based on this. First, regarding the environmental aspect, it can be observed that there is an effort to secure sustainability. Second, in terms of social sustainability, historical value remains as a trace of architectural place, so that it continues in people’s memory. In addition, public architecture provides public places where citizens can gather and enjoy programs, while the architectural methods showed differences influenced by cultural conditions. Third, in economic sustainability, it was shown that energy saving was achieved through cost reduction through recycling of materials, facilities, or environmental factors. In conclusion, the issues to be considered in public architectural design are the voiding of urban space through architectural devices in the construction method. In other words, the intention is to form “ground” that attempts to be part of the city, and thereby create better places. Since skin and material have a deep relationship with the environment, they should have the durability and an outer skin that are suitable for the regional environment. Finally, sustainability is to be utilized through the influx of programs that meet local and environmental characteristics. Design research into public architecture that is oriented towards urban sustainability will be a task to be carried out by the

Consumer Sustainability and Responsibility: Beyond Green and Ethical Consumption

Directory of Open Access Journals (Sweden)

Maja Hosta

2016-12-01

Full Text Available Purpose – Most literature regarding sustainable behavior is based on the assumption that the reduction of consumption is inherently positive (mainly in the form of positive environmental consequences and based on ethical considerations. However, the issue of the social consequences of this reduction and self-interested intentions in consumption is not generally open to debate. This paper aims to identify dimensions of sustainable and responsible consumer behavior, distinguish between the two concepts, and present consumer obstacles to acting responsibly in all aspects that a sustainability agenda would suggest. Design/Methodology/Approach – The paper includes a literature review, proposes a framework of responsible and sustainable consumption (RSCB, and offers a set of propositions to achieve responsible and sustainable consumption. Insights from personal interviews with consumers are added for the sake of additional understanding of the concepts presented. Findings and implications – Through the RSCB framework, we show the potential trade-off decisions consumers have to make in order to implement sustainability and responsibility issues in everyday consumer decision processes. Struggles between doing what is good for them and what is good for the environment and society could be a reason why consumers have difficulties achieving responsible and sustainable consumption. Limitations – Qualitative study based on a small sample of personal interviews does not allow for generalizations. Originality – A research gap in understanding the dimensions of sustainable and responsible consumer actions in terms of their emphasis (environmental and social and intentions (self-interest and other-interest is addressed. By understanding those two dimensions of behavior, managers and consumers can resolve consumer sustainability and responsibility dilemmas that arise from a one-dimensional view in order to move sustainability research and practice

Fleet renewal: An approach to achieve sustainable road transport

Directory of Open Access Journals (Sweden)

Manojlović Aleksandar V.

2011-01-01

Full Text Available With more stringent requirements for efficient utilization of energy resources within the transport industry a need for implementation of sustainable development principles has appeared. Such action will be one of competitive advantages in the future. This is especially confirmed within the road transport sector. A methodology implemented in public procurement procedures for fleet renewal regarding the calculation of road vehicles’ operational lifecycle costs has been analyzed in detail in this paper. Afore mentioned calculation comprises the costs for: vehicle ownership, energy, carbon dioxide and pollutants emissions. Implementation of this methodology allows making the choice of energy efficient vehicles and vehicles with notable positive environmental effects. The objective of the research is to assess the influence of specific parameters of vehicle operational lifecycle costs, especially energy costs and estimated vehicle energy consumption, on vehicle choice in the procurement procedure. The case of urban bus fleet in Serbia was analyzed. Their operational lifecycle costs were calculated and differently powered vehicles were assessed. Energy consumption input values were defined. It was proved that defined fleet renewal scenarios could influence unquestionable decrease in energy consumption.

Wood Energy Production, Sustainable Farming Livelihood and Multifunctionality in Finland

Science.gov (United States)

Huttunen, Suvi

2012-01-01

Climate change and the projected depletion of fossil energy resources pose multiple global challenges. Innovative technologies offer interesting possibilities to achieve more sustainable outcomes in the energy production sector. Local, decentralized alternatives have the potential to sustain livelihoods in rural areas. One example of such a…

Transport systems and policies for sustainable cities

Directory of Open Access Journals (Sweden)

Vučić Vukan R.

2008-01-01

Full Text Available The 20th century witnessed revolutionary developments in transportation technology with major impacts on the form and character of cities. Progress in increasing mobility has brought many benefits as well as serious problems, particularly in deterioration of livability and sustainability. Increase in auto ownership led to serious problems of chronic traffic congestion. Attempts to rebuild cities to provide full accommodation of private cars have led to serious problems of auto dependency and deterioration of cities. Experiences from recent decades have shown that urban transportation is much more complex than usually realized. Livable and sustainable cities require policies that lead to creation of a transportation system consisting of coordinated public transit and private cars, and encourages pedestrian environment and efficient, sustainable development. Great need for better understanding of the complex problems in implementing incentives and disincentives aimed at achieving intermodal balance is emphasized. Brief descriptions of cities which lead in achieving such livable conditions is followed by a summary of lessons and guidelines for the future.

Nanotechnology for sustainable development: retrospective and outlook

Science.gov (United States)

Diallo, Mamadou S.; Fromer, Neil A.; Jhon, Myung S.

2013-11-01

The world is facing great challenges in meeting rising demands for basic commodities (e.g., food, water and energy), finished goods (e.g., cell phones, cars and airplanes) and services (e.g., shelter, healthcare and employment) while reducing and minimizing the impact of human activities on Earth's global environment and climate. Nanotechnology has emerged as a versatile platform that could provide efficient, cost-effective and environmentally acceptable solutions to the global sustainability challenges facing society. This special issue of the Journal of Nanoparticle Research is devoted to the utilization of nanotechnology to improve or achieve sustainable development. We highlight recent advances and discuss opportunities of utilizing nanotechnology to address global challenges in (1) water purification, (2) clean energy technologies, (3) greenhouse gases management, (4) materials supply and utilization, and (5) green manufacturing and chemistry. In addition to the technical challenges listed above, we also discuss societal perspectives and provide an outlook of the role of nanotechnology in the convergence of knowledge, technology and society for achieving sustainable development.

Nanotechnology for sustainable development: retrospective and outlook

International Nuclear Information System (INIS)

Diallo, Mamadou S.; Fromer, Neil A.; Jhon, Myung S.

2013-01-01

The world is facing great challenges in meeting rising demands for basic commodities (e.g., food, water and energy), finished goods (e.g., cell phones, cars and airplanes) and services (e.g., shelter, healthcare and employment) while reducing and minimizing the impact of human activities on Earth’s global environment and climate. Nanotechnology has emerged as a versatile platform that could provide efficient, cost-effective and environmentally acceptable solutions to the global sustainability challenges facing society. This special issue of the Journal of Nanoparticle Research is devoted to the utilization of nanotechnology to improve or achieve sustainable development. We highlight recent advances and discuss opportunities of utilizing nanotechnology to address global challenges in (1) water purification, (2) clean energy technologies, (3) greenhouse gases management, (4) materials supply and utilization, and (5) green manufacturing and chemistry. In addition to the technical challenges listed above, we also discuss societal perspectives and provide an outlook of the role of nanotechnology in the convergence of knowledge, technology and society for achieving sustainable development

Nanotechnology for sustainable development: retrospective and outlook

Energy Technology Data Exchange (ETDEWEB)

Diallo, Mamadou S., E-mail: mdiallo@kaist.ac.kr [Korea Advanced Institute of Science and Technology (KAIST), Graduate School of Energy, Environment, Water and Sustainability (EEWS) (Korea, Republic of); Fromer, Neil A. [California Institute of Technology, Resnick Sustainability Institute (United States); Jhon, Myung S. [Carnegie Mellon University, Department of Chemical Engineering (United States)

2013-11-15

The world is facing great challenges in meeting rising demands for basic commodities (e.g., food, water and energy), finished goods (e.g., cell phones, cars and airplanes) and services (e.g., shelter, healthcare and employment) while reducing and minimizing the impact of human activities on Earth’s global environment and climate. Nanotechnology has emerged as a versatile platform that could provide efficient, cost-effective and environmentally acceptable solutions to the global sustainability challenges facing society. This special issue of the Journal of Nanoparticle Research is devoted to the utilization of nanotechnology to improve or achieve sustainable development. We highlight recent advances and discuss opportunities of utilizing nanotechnology to address global challenges in (1) water purification, (2) clean energy technologies, (3) greenhouse gases management, (4) materials supply and utilization, and (5) green manufacturing and chemistry. In addition to the technical challenges listed above, we also discuss societal perspectives and provide an outlook of the role of nanotechnology in the convergence of knowledge, technology and society for achieving sustainable development.

Role of Biocatalysis in Sustainable Chemistry

DEFF Research Database (Denmark)

Sheldon, Roger A; Woodley, John M.

2018-01-01

Based on the principles and metrics of green chemistry and sustainable development, biocatalysis is both a green and sustainable technology. This is largely a result of the spectacular advances in molecular biology and biotechnology achieved in the past two decades. Protein engineering has enabled...... successfully been applied, for example, in the industrial synthesis of active pharmaceutical ingredients. In addition to the use of protein engineering, other aspects of biocatalysis engineering, such as substrate, medium, and reactor engineering, can be utilized to improve the efficiency and cost...

An Analysis of Determinants of Under-5 Mortality across Countries: Defining Priorities to Achieve Targets in Sustainable Developmental Goals.

Science.gov (United States)

Acheampong, Michael; Ejiofor, Chukwudi; Salinas-Miranda, Abraham

2017-06-01

Objectives The end of the era of millennium development goals (MDGs) ushered in the sustainable development goals (SDGs) with a new target for the reduction of under-five mortality rates (U5MR). Although U5MR decreased globally, the reduction was insufficient to meet MDGs targets because significant socioeconomic inequities remain unaddressed across and within countries. Thus, further progress in achieving the new SDGs target will be hindered if there is no adequate prioritization of important socioeconomic, healthcare, and environmental factors. The objective of this study was to assess factors that account most for the differences in U5MR between countries around the globe. Methods We conducted an ordinary least squares (OLS) regression-based prioritization analysis of socioeconomic, healthcare, and environmental variables from 109 countries to understand which factors explain the differences in U5MR best. Results All indicators examined individually affected differences in U5MR between countries. However, the results of multivariate OLS regression showed that the most important factors that accounted for the differences were, in order: fertility rate, total health expenditure per capita, access to improved water and sanitation, and female employment rate. Conclusions To achieve the new global target for U5MR, policymakers must focus on certain priority areas, such as interventions that address access to affordable maternal healthcare services, educational programs for mothers, especially those who are adolescents, and safe drinking water and sanitation.

Sustainable Materials Management (SMM) WasteWise Data

Data.gov (United States)

U.S. Environmental Protection Agency — EPA’s WasteWise encourages organizations and businesses to achieve sustainability in their practices and reduce select industrial wastes. WasteWise is part of EPA’s...

Organising Sustainability Competencies through Quality Management: Integration or Specialisation

Directory of Open Access Journals (Sweden)

Vanajah Siva

2018-04-01

Full Text Available A significant step in integrating environmental sustainability into daily operations is through product development. One way to achieve such integration of environmental considerations into product development is by relating sustainability competencies to practices of Quality Management. However, practices seem to vary for how competencies within environmental sustainability are organised in order to make sustainability more actionable. This study explores two ways of organising sustainability competencies in product development: integration and specialisation. The organisation of sustainability competency is illustrated through two cases; one case in which sustainability is integrated with the quality management competency, and the other in which a new competency focusing on sustainability has been added as a separate function in product development. It is suggested that the organisation of sustainability competency influences the extent of environmental impact. Further, trade-offs, such as material source versus weight may not be exploited when sustainability is integrated as one area of responsibility for another specialty competency, suggesting a lack of sufficient competency within environmental sustainability to recognise potential trade-offs between—for example—quality and environmental impact.

Towards sustainable food production

DEFF Research Database (Denmark)

Aramyan, Lusine H; Hoste, Robert; van den Broek, Willie

2011-01-01

continuous innovation of supply chain network structures, reconsideration of business processes, relocation of logistics infrastructures and renewed allocation of chain activities to these infrastructures in order to achieve sustainable performances. This paper presents a scenario analysis of the spatial...... of pigs, processing of pork and pork consumption, is used to analyse the scenarios. The results reveal major opportunities for reductions in cost as well as in CO2 equivalent emissions if a European sector perspective is taken and some chain activities are relocated to other countries. However......, as minimizing costs will not always lead to an optimal reduction in CO2 equivalent emissions, a differentiated strategy is needed for the European pork sector to move towards more sustainable production...

Improving Sustainability Performance for Public-Private-Partnership (PPP Projects

Directory of Open Access Journals (Sweden)

Liyin Shen

2016-03-01

Full Text Available Improving sustainability performance in developing infrastructure projects is an important strategy for pursuing the mission of sustainable development. In recent years, the business model of public-private-partnership (PPP is promoted as an effective approach in developing infrastructure projects. It is considered that the distribution of the contribution on project investment between private and public sectors is one of the key variables affecting sustainability performance of PPP-type projects. This paper examines the impacts of the contribution distribution between public and private sectors on project sustainability performance. A model named the sustainability performance-based evaluation model (SPbEM is developed for assisting the assessment of the level of sustainability performance of PPP projects. The study examines the possibility of achieving better sustainability through proper arrangement of the investment distribution between the two primary sectors in developing PPP-type infrastructure projects.

Interpretations of the Concept of Sustainability Amongst the UK’s Leading Food and Drink Wholesalers

Directory of Open Access Journals (Sweden)

Peter Jones

2016-12-01

Full Text Available Purpose – The aim of this paper is to provide an exploratory review of the interpretations of the concept of sustainability amongst the UK’s leading food and drinks wholesalers, as revealed by the sustainability agendas and achievements reported on their corporate websites. Design/Methodology/Approach – The paper begins with short introductions to sustainability, corporate sustainability and sustainability reporting, and food and drinks wholesaling within the UK. The empirical material for the paper is drawn from reports and information posted on the leading food and drinks wholesalers’ corporate websites. Findings and implications – There are marked variations in the extent to which the UK’s leading food and drinks wholesalers reported and provided information on their sustainability agendas and achievements. These agendas and achievements embraced a wide range of environmental, social and economic issues, but the reporting process had a number of weaknesses that undermined its transparency and credibility. The authors also argue that the leading food and drinks wholesalers’ definitions of, and commitments to, sustainability are principally driven by business imperatives as by any fundamental concern to maintain the viability and integrity of natural and social capital. Limitations – The paper is a preliminary review of the sustainability agendas and achievements publicly reported by the UK’s leading food and drinks wholesalers. Originality – Within the food and drinks supply chain, wholesalers have a pivotal role at the interface between producers, manufacturers, retail and service providers, and as such they can play in promoting sustainability. However, the role of the UK’s wholesale sector in addressing sustainability has received scant attention in the academic literature, so this paper will interest academics and students in business management and marketing.

In search of a holistic, sustainable and replicable model for complete energy refurbishment in historic buildings

Directory of Open Access Journals (Sweden)

Marija S. Todorović

2012-12-01

Full Text Available The reduction of greenhouse gas emissions in buildings offers one of the most promising opportunities for developed and developing countries to cooperate in achieving the realization of significant energy efficiency improvements. However, achieving sustainability is not an easy task unless there is synergy with/between energy efficiency improvement and renewable energy sources (RES - these are not at present in widespread dissemination and use. This paper recognizes the synergetic relationship between conservation and sustainability. At present, the role of heritage conservation in achieving sustainability has not yet been fully recognized, nor have heritage needs been well integrated into sustainability initiatives. Historic buildings are inherently sustainable. Preservation maximizes the use of existing materials and infrastructures, reduces waste, and preserves the historical character of older towns and cities. Sustainability begins with preservation. Taking into account the original climatic adaptations of historic buildings, today’s sustainable technology can supplement inherent sustainable features without compromising their unique historical character. Furthermore, a number of paper reviews and case studies with related methodologies outline the need to implement the latest current knowledge and technologies (BPS - Building Performance Simulation and CFD - Computational Fluid Dynamics for use in the refurbishment design process, as well as highlighting the crucial importance of sustainability, relevant benchmarking and rating system development.

Not planning a sustainable transport system

International Nuclear Information System (INIS)

Finnveden, Göran; Åkerman, Jonas

2014-01-01

The overall objective of the Swedish transport policy is to ensure the economically efficient and sustainable provision of transport services for people and business throughout the country. More specifically, the transport sector shall, among other things, contribute to the achievement of environmental quality objectives in which the development of the transport system plays an important role in the achievement of the objectives. The aim of this study is to analyse if current transport planning supports this policy. This is done by analysing two recent cases: the National Infrastructure Plan 2010–2021, and the planning of Bypass Stockholm, a major road investment. Our results show that the plans are in conflict with several of the environmental quality objectives. Another interesting aspect of the planning processes is that the long-term climate goals are not included in the planning processes, neither as a clear goal nor as factor that will influence future transport systems. In this way, the long-term sustainability aspects are not present in the planning. We conclude that the two cases do not contribute to a sustainable transport system. Thus, several changes must be made in the processes, including putting up clear targets for emissions. Also, the methodology for the environmental assessments needs to be further developed and discussed. - Highlights: • Two cases are studied to analyse if current planning supports a sustainable transport system. • Results show that the plans are in conflict with several of the environmental quality objectives. • Long-term climate goals are not included in the planning processes. • Current practices do not contribute to a sustainable planning processes. • Methodology and process for environmental assessments must be further developed and discussed

Not planning a sustainable transport system

Energy Technology Data Exchange (ETDEWEB)

Finnveden, Göran, E-mail: goran.finnveden@abe.kth.se; Åkerman, Jonas

2014-04-01

The overall objective of the Swedish transport policy is to ensure the economically efficient and sustainable provision of transport services for people and business throughout the country. More specifically, the transport sector shall, among other things, contribute to the achievement of environmental quality objectives in which the development of the transport system plays an important role in the achievement of the objectives. The aim of this study is to analyse if current transport planning supports this policy. This is done by analysing two recent cases: the National Infrastructure Plan 2010–2021, and the planning of Bypass Stockholm, a major road investment. Our results show that the plans are in conflict with several of the environmental quality objectives. Another interesting aspect of the planning processes is that the long-term climate goals are not included in the planning processes, neither as a clear goal nor as factor that will influence future transport systems. In this way, the long-term sustainability aspects are not present in the planning. We conclude that the two cases do not contribute to a sustainable transport system. Thus, several changes must be made in the processes, including putting up clear targets for emissions. Also, the methodology for the environmental assessments needs to be further developed and discussed. - Highlights: • Two cases are studied to analyse if current planning supports a sustainable transport system. • Results show that the plans are in conflict with several of the environmental quality objectives. • Long-term climate goals are not included in the planning processes. • Current practices do not contribute to a sustainable planning processes. • Methodology and process for environmental assessments must be further developed and discussed.

Key Sustainability Performance Indicator Analysis for Czech Breweries

Directory of Open Access Journals (Sweden)

Edward Kasem

2015-01-01

Full Text Available Sustainability performance can be said to be an ability of an organization to remain productive over time and hold on to its potential for maintaining long-term profitability. Since the brewery sector is one of the most important and leading markets in the foodstuff industry of the Czech Republic, this study depicts the Czech breweries’ formal entry into sustainability reporting and performance. The purpose of this paper is to provide an efficiency level evaluation which would represent the level of corporate performance of Czech breweries. For this reason, Data Envelopment Analysis (DEA is introduced. In order to apply it, we utilize a set of key performance indicators (KPIs based on two international standard frameworks: the Global Reporting Initiative (GRI and its GRI 4 guidelines, and the guideline KPIs for ESG 3.0, which was published by the DVFA Society. Four sustainability dimensions (economic, environmental, social and governance are covered, making it thus possible to adequately evaluate sustainability performance in Czech breweries. The main output is not only the efficiency score of the company but also the input weights. These weights are used to determine the contribution of particular criteria to the breweries’ achieved score. According to the achieved efficiency results for Czech breweries, the percentage of women supervising the company does not affect the sustainability performance.

Contribution of Nuclear Science in Agriculture Sustainability

International Nuclear Information System (INIS)

Soliman, S.M.; Galal, Y.G.M.

2017-01-01

Sustainable agricultural systems employ natural processes to achieve acceptable levels of productivity and food quality while minimizing adverse environmental impacts. Sustainable agriculture must, by definition, be ecologically sound, economically viable, and socially responsible. Sustainable agriculture must nurture healthy co systems and support the sustainable management of land, water and natural resources, while ensuring world food security. To be sustainable, agriculture must meet the needs of present and future generations for its products and services, while ensuring profitability, environmental health and social and economic equity. The global transition to sustainable food and agriculture will require major improvements in the efficiency of resource use, in environmental protection and in systems resilience. In Mediterrane an environments, crops are grown mainly in the semiarid and sub-humid are as. In arid and semiarid are as dry land farming, techniques are of renewed interest in the view of sustain ability. They are aimed to increase water accumulation in the soil, reduce runoff and soil evaporation losses, choose species and varieties able to make better use of rainwater, and rationalize fertilization plans, sowing dates, and weed and pest control. Fertilization plans should be based on well-defined principles of plant nutrition, soil chemistry, and chemistry of the fertilizer elements. Starting from the calculation of nutrient crop uptake (based on the actually obtainable yield), dose calculation must be corrected by considering the relation ship between the availability of the trace elements in soil and the main physical and chemical parameters of the soil (ph, organic matter content, mineralization rate, C/N, ratio of solubilization of phosphorus, active lime content, presence of antagonist ions, etc.). In the Egyptian Atomic Energy Authority, Soil and Water Research Department, nuclear techniques including radio and stable isotopes in addition to

Probabilistic design framework for sustainable repari and rehabilitation of civil infrastructure

DEFF Research Database (Denmark)

Lepech, Michael; Geiker, Mette Rica; Stang, Henrik

2011-01-01

This paper presents a probabilistic-based framework for the design of civil infrastructure repair and rehabilitation to achieve targeted improvements in sustainability indicators. The framework consists of two types of models: (i) service life prediction models combining one or several deteriorat......This paper presents a probabilistic-based framework for the design of civil infrastructure repair and rehabilitation to achieve targeted improvements in sustainability indicators. The framework consists of two types of models: (i) service life prediction models combining one or several...

Sprawl and sustainable urban development in Europe

Directory of Open Access Journals (Sweden)

Maksin-Mićić Marija

2008-01-01

Full Text Available Over 50 years urban development in Europe has been affected by extensive urban sprawl. Environmental, economic and social impacts of long lasting sprawl are threatening urban identity, urban culture and cultural identity of European territory. Last two decades the main concept in European planning and governance system has been the sustainable development, namely sustainable urban development and its implementation. We ought to be realistic about the possibilities to counter sprawl. Realistic seams to steer sprawling tendencies in more suitable and sustainable manner, so called smart urban sprawl. This paper analyses the planning concepts and gives the brief review of current policies for steering the urban sprawl in EU, which are considered to be of importance in achieving more sustainable urban development and efficient urban management in Serbia.

From Science, Engineering and Innovation to Sustainable Development: The Path Forward

Science.gov (United States)

Turekian, Vaughan

2017-01-01

In September 2015, world leaders committed to a new 2030 Agenda for Sustainable Development, with 17 Sustainable Development Goals (SDGs) aimed at ending poverty, hunger and inequality, taking action on the environment and climate change, and improving access to health and education. Science, technology and innovation (STI) underpin the achievement of all of the SDGs, whether it is expanding access to health services and quality education; improving food security; and access to clean water and sanitation; building transparent, accountable, and stable institutions; empowering women and minorities; or promoting the sustainable management and use of renewable energy and natural resources. The goals speak to a broad range of directions the world needs to go to promote economic, environmental, and social well-being. The goals are interdependent and achieving one will only be possible by achieving all. We have an obligation to take necessary steps that integrate all the different stakeholders and constant advances in innovation, science, and technology.

The economy and the environment. In search of sustainable development. Extensive summary

International Nuclear Information System (INIS)

1996-10-01

In recent years, there has been much debate regarding environmental policy and ways of achieving sustainable development. Several definitions of sustainable development have been proposed. Most, however, are highly abstract and do not provide environmental policymakers with an operational framework. The problem is addressed in this working paper by attempting to identify ways of achieving sustainable growth in the Netherlands. As the title suggests, a clear and practicable definition of sustainable development has yet to be found. The report has been part of a project organized in conjunction with the National Institute of Public Health and Environmental Protection (RIVM). It starts with a theoretical examination of the concept of sustainable development. After a brief review of events in the Netherlands in the last ten years and projections for the next twenty years, the report goes on to present four case-study reports on specific environmental problems (greenhouse gases, manure, traffic and transport and the depletion of natural resources)

Urban sustainability through strategic planning: A case of metropolitan planning in Khulna city, Bangladesh

Directory of Open Access Journals (Sweden)

Md. Ashiq Ur Rahman

2016-06-01

Full Text Available Planning is a crucial element for any development initiative. Planning entails choice making in pursuit of stated goals e.g. improving living conditions for individuals and societies. Planning initiatives are employed within social systems that are governed by institution, and planning intervenes with and may reconfigure these institutions resulting in social change. This paper discusses how urban sustainability can be achieved through strategic action in urban development by analysing the planning process of Khulna city, Bangladesh. This paper reviews different scholarly articles to draw a conceptual framework for identifying the interface of strategic planning, components of strategic action planning and urban sustainability. Based on this conceptual framework this paper identifies the scope of achieving urban sustainability through analysing the current planning practice of Khulna city, Bangladesh. This paper identifies that though the Khulna city plan adopted the approach of strategic planning but it failed to comply with its theoretical notion to achieve the issues related to urban sustainability. Analysis reveals that in terms of social attribute that recognizes the interest of different group of people the exiting planning packages is not sustainable. Similar phenomenon have been observed in terms of recognition of gender and marginalized people in planning, equitable provision of income and employment generation, peoples’ participation in planning and polices for ensuring equitable access to infrastructure services. Therefore the existing planning package of Khulna city failed to achieve the issues of urban sustainability through its adapted strategic planning approach.

Southern Africa power pool : benefits, achievements, challenges and sustainability

International Nuclear Information System (INIS)

Anderson, G.O.; Opok, A.O.

2008-01-01

An overview of the Southern Africa Power Pool (SAPP) was presented. The SAPP was formed by 12 southern African developing countries as a means of minimizing electricity costs and maintaining reliability. The pool includes over 200 million people in a region of 9 million square meters. The SAPP relies on long-term bilateral contracts for electricity supply between customers and generators. The contracts are supplemented by short-term contracts in the short-term energy market. The pool uses a pricing mechanism with 13 detailed schedules dealing with firm power contracts of varying duration; non-firm power contracts of varying duration; mutual support contracts and emergency energy and control area services; scheduled outage energy; and energy banking. Benefits of the pool include reductions or postponements in generating capacity, reserves and fuel costs. New major initiatives planned by the SAPP include increasing interconnection points, the construction of new transmission lines, and the formulation of regional environmental studies. SAPP is now making plans to increase rural electrification in its membership countries with funding from an electricity levy. It was concluded that political and economic co-operation between member states has resulted in the sustained supply of energy in the region. 10 refs., 7 tabs., 3 figs

Therapeutic γ-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms

Science.gov (United States)

Dai, Yan; Sangerman, Jose; Hong, Yuan Luo; Fuchareon, Suthat; Chui, David H.K.; Faller, Douglas V.; Perrine, Susan P.

2015-01-01

Pharmacologic augmentation of γ-globin expression sufficient to reduce anemia and clinical severity in patients with diverse hemoglobinopathies has been challenging. In studies here, representative molecules from four chemical classes, representing several distinct primary mechanisms of action, were investigated for effects on γ-globin transcriptional repressors, including components of the NuRD complex (LSD1 and HDACs 2-3), and the downstream repressor BCL11A, in erythroid progenitors from hemoglobinopathy patients. Two HDAC inhibitors (MS-275 and SB939), a short-chain fatty acid derivative (sodium dimethylbutyrate [SDMB]), and an agent identified in high-throughput screening, Benserazide, were studied. These therapeutics induced γ globin mRNA in progenitors above same subject controls up to 20-fold, and increased F-reticulocytes up to 20%. Cellular protein levels of BCL11A, LSD-1, and KLF1 were suppressed by the compounds. Chromatin immunoprecipitation assays demonstrated a 3.6-fold reduction in LSD1 and HDAC3 occupancy in the γ-globin gene promoter with Benserazide exposure, 3-fold reduction in LSD-1 and HDAC2 occupancy in the γ-globin gene promoter with SDMB exposure, while markers of gene activation (histone H3K9 acetylation and H3K4 demethylation), were enriched 5.7-fold. These findings identify clinical-stage oral therapeutics which inhibit or displace major co-repressors of γ-globin gene transcription and may suggest a rationale for combination therapy to produce enhanced efficacy. PMID:26603726

INEQUALITY IN CHINA IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT

Directory of Open Access Journals (Sweden)

Чжан Чжань

2017-12-01

Full Text Available The research object is the sociopolitical foundations of sustainable development in China. Research subject is the problem of inequality as one of the obstacles to sustainable development in China. In the article, different aspects of the issue are reviewed in the context of sustainable development, especially through the requirements of the UN Agenda 2030. These aspects include income inequality, inequality in education and health care, gender inequality. It is shown that despite the improvement trend in some specific aspects, the inequality gap in China is still large, further reduction of the inequality level remains one of the main tasks for achieving sustainable development goals in China.

Current State and Future Prospects of Education for Sustainable Development (ESD) in Japan

Science.gov (United States)

Tanaka, Haruhiko

2017-01-01

The UN Decade of Education for Sustainable Development (ESD) ran from 2005 to 2014. This study concerns the concepts of Sustainable Development (SD) and ESD. The term "sustainable development" was coined by the Brundtland Commission in 1987 as the key word in integrating environment and development. SD achieved international consensus at…

Measurement of sustainability index among paper manufacturing plants

Science.gov (United States)

Sharathkumar Reddy, V.; Jayakrishna, K.; Lal, Babu

2017-11-01

The paper manufacturing companies are facing challenges to implement sustainable manufacturing into their products and processes. Paper manufacturing has remarked as an intensive consumer of natural raw materials, energy and a major source of multiple pollutants. Thus, evaluating the sustainable manufacturing in these companies has become a necessity. This paper proposes a set of Performance Indicators (PIs) for evaluating the sustainable manufacturing appropriate to the paper manufacturing companies based on the triple bottom line of sustainability. The Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), a multi-criteria decision analysis method is applied to prioritize the performance indicators by summarizing the opinions of stakeholders. It is hoped that the proposed PIs enables and assists the paper manufacturing companies to achieve the higher performance in sustainable manufacturing and so as to increase their competitiveness.

Exploring mechanisms for mobilising industrial sustainability models across different industrial locations

DEFF Research Database (Denmark)

Jacobsen, Ole Morten Noel Brings

2009-01-01

Industrial symbiosis is a model of sustainability which suggests that agglomerations of industries can achieve considerable environmental benefits by engaging in inter-organisational waste recycling, energy cascading and water recovery. This article considers how such a complex inter-organisation......Industrial symbiosis is a model of sustainability which suggests that agglomerations of industries can achieve considerable environmental benefits by engaging in inter-organisational waste recycling, energy cascading and water recovery. This article considers how such a complex inter...... symbiosis model may in this way be mobilised across industrial localities as part of the global corporate search for marked access and cost reductions. This suggestion is supported by an illustrative case study shedding some light on the mechanisms for mobilising sustainability models across localities....

A pulser-sustainer carbon monoxide electric-discharge supersonic laser

Science.gov (United States)

Monson, D. J.; Srinivasan, G.

1977-01-01

Operation of a CW CO electric-discharge supersonic laser with a pulser-sustainer discharge is described. High-power operation as well as independent control over electron energy and density are demonstrated. Maximum input power achieved to date is 100 kW. The maximum output power is 6 kW or 10% of the sustainer positive-column power. Much improved performance appears possible.

Sustainable energy policy - implementation needs

Energy Technology Data Exchange (ETDEWEB)

Jefferson, M. [Global Energy and Environmental Consultants, Felmersham (United Kingdom)

2000-07-01

Implementation of sustainable energy must address current needs arising from poverty, inequity, unreliability of supplies, social and economic development requirements, and increasing efficiency as well as widening the fuel mix, accelerating the deployment of appropriate new renewable energy schemes, and giving the necessary consideration to protection of the biosphere and the needs of future generations. To achieve these multiple goals markets need to work better, additional investments need to be mobilised in sustainable energy, technological innovation needs to be encouraged, technological diffusion and capacity building in developing countries needs to be supported, and both sounder domestic policies and greater international co-operation are required. (author)

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

International Nuclear Information System (INIS)

Kim, Jiyoung; Cha, Young-Nam; Surh, Young-Joon

2010-01-01

Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a key transcription factor that plays a central role in cellular defense against oxidative and electrophilic insults by timely induction of antioxidative and phase-2 detoxifying enzymes and related stress-response proteins. The 5'-flanking regions of genes encoding these cytoprotective proteins contain a specific consensus sequence termed antioxidant response element (ARE) to which Nrf2 binds. Recent studies have demonstrated that Nrf2-ARE signaling is also involved in attenuating inflammation-associated pathogenesis, such as autoimmune diseases, rheumatoid arthritis, asthma, emphysema, gastritis, colitis and atherosclerosis. Thus, disruption or loss of Nrf2 signaling causes enhanced susceptibility not only to oxidative and electrophilic stresses but also to inflammatory tissue injuries. During the early-phase of inflammation-mediated tissue damage, activation of Nrf2-ARE might inhibit the production or expression of pro-inflammatory mediators including cytokines, chemokines, cell adhesion molecules, matrix metalloproteinases, cyclooxygenase-2 and inducible nitric oxide synthase. It is likely that the cytoprotective function of genes targeted by Nrf2 may cooperatively regulate the innate immune response and also repress the induction of pro-inflammatory genes. This review highlights the protective role of Nrf2 in inflammation-mediated disorders with special focus on the inflammatory signaling modulated by this redox-regulated transcription factor.

Biodiversity Change and Sustainable Development: New Perspectives

OpenAIRE

Tisdell, Clement A.

2012-01-01

Biodiversity is usually regarded as an asset or resource, the stock of which is partly natural and partly determined by humans. Humans both subtract from and add to this stock and consequently, the change in the stock is heterogeneous. This heterogeneity is not taken account of by some authors who focus only on the loss aspect. Frequently, the conservation of this stock is seen as important for the achievement of sustainable development; sustainable development being defined (but not always a...

Urban planning, public transit and related initiatives for more sustainable transportation

International Nuclear Information System (INIS)

1995-11-01

The characteristics of ten Canadian cities and their transportation systems were summarized. The need to conserve resources and to maintain environmental quality has lead to initiatives aimed at achieving more sustainable urban transportation. The most promising initiatives to reduce greenhouse gas emissions and achieve other sustainability objectives were described. Ways to overcome the most significant barriers were suggested. Since suburban areas are generally automobile-dependant, the major challenge is how to retrofit these areas with high quality transit services. A corollary objective is to achieve more compact, mixed-use urban structure and pedestrian-friendly streetscapes, thereby reducing average trip distances and making it feasible for the transit, walking and cycling modes to be used more extensively. refs., tabs., figs

Sustainable performance of microinsurance in low-income markets

Directory of Open Access Journals (Sweden)

Last Mazambani

2018-06-01

Full Text Available Sustainable performance in microinsurance offering in low-income markets is important to ensure that the service simultaneously achieves corporate profitability and poverty alleviation. Sustainable performance requires a balanced integration of supply and demand factors in the offering of the service. Microinsurance is still supply driven thereby creating a lopsided mismatch between demand and supply that leads to oversupply and low uptake. On the basis of extant literature, the paper aims to propose and discuss factors critical to demand and supply of microinsurance. A conceptual framework for sustainable microinsurance is presented with individual metrics that can be addressed as managerial tools for driving and controlling sustained superior performance. While this is a theoretical paper, microinsurance practitioners may benefit from the application of the presented theory

A Fuzzy Comprehensive Evaluation Model for Sustainability Risk Evaluation of PPP Projects

Directory of Open Access Journals (Sweden)

Libiao Bai

2017-10-01

Full Text Available Evaluating the sustainability risk level of public–private partnership (PPP projects can reduce project risk incidents and achieve the sustainable development of the organization. However, the existing studies about PPP projects risk management mainly focus on exploring the impact of financial and revenue risks but ignore the sustainability risks, causing the concept of “sustainability” to be missing while evaluating the risk level of PPP projects. To evaluate the sustainability risk level and achieve the most important objective of providing a reference for the public and private sectors when making decisions on PPP project management, this paper constructs a factor system of sustainability risk of PPP projects based on an extensive literature review and develops a mathematical model based on the methods of fuzzy comprehensive evaluation model (FCEM and failure mode, effects and criticality analysis (FMECA for evaluating the sustainability risk level of PPP projects. In addition, this paper conducts computational experiment based on a questionnaire survey to verify the effectiveness and feasibility of this proposed model. The results suggest that this model is reasonable for evaluating the sustainability risk level of PPP projects. To our knowledge, this paper is the first study to evaluate the sustainability risk of PPP projects, which would not only enrich the theories of project risk management, but also serve as a reference for the public and private sectors for the sustainable planning and development. Keywords: sustainability risk eva

Networks as Tools for Sustainable Urban Development

DEFF Research Database (Denmark)

Jensen, Jesper Ole; Tollin, Nicola

will be discussed through a case study of a Danish municipal network on Sustainable Development, Dogme 20001. This network has become quite successful in terms of learning and innovation, committing actors, and influencing local policies, to a larger extent than other SUD-networks the municipalities are involved in....... By applying the GREMI2-theories of “innovative milieux” (Aydalot, 1986; Camagni, 1991) to the case study, we will suggest some reasons for the benefits achieved by the Dogme-network, compared to other networks. This analysis will point to the existence of an “innovative milieu” on sustainability within......Due to the increasing number of networks related to sustainable development (SUD) the paper focuses on understanding in which way networks can be considered useful tools for sustainable urban development, taking particularly into consideration the networks potential of spreading innovative policies...

Strategies for achieving a sustainable, clean and cost-effective biomass resource

International Nuclear Information System (INIS)

Turnbull, J.

1993-01-01

Biomass produced in an economically and environmentally sustainable manner, could realistically be used to supply 50,000 MW (5 Quads) of electric capacity by the year 2010 and probably twice that amount by the year 2030. During the past year, the Electric Power Research Institute (EPRI) and the U.S. Department of Energy (DOE) have each been independently evaluating the potential for biomass to become a major renewable energy resource over the next four decades, able to offset some of the U.S. dependency on imported fossil fuels while also offering important environmental and economic benefits. This paper presents EPRI's conclusions, which are more conservative than those of DOE, and outlines possible strategies by which EPRI can advance acceptance of biomass as a preferred renewable resource

The development of a sustainable development model framework

International Nuclear Information System (INIS)

Hannoura, Alim P.; Cothren, Gianna M.; Khairy, Wael M.

2006-01-01

The emergence of the 'sustainable development' concept as a response to the mining of natural resources for the benefit of multinational corporations has advanced the cause of long-term environmental management. A sustainable development model (SDM) framework that is inclusive of the 'whole' natural environment is presented to illustrate the integration of the sustainable development of the 'whole' ecosystem. The ecosystem approach is an inclusive framework that covers the natural environment relevant futures and constraints. These are dynamically interconnected and constitute the determinates of resources development component of the SDM. The second component of the SDM framework is the resources development patterns, i.e., the use of land, water, and atmospheric resources. All of these patterns include practices that utilize environmental resources to achieve a predefined outcome producing waste and by-products that require disposal into the environment. The water quality management practices represent the third component of the framework. These practices are governed by standards, limitations and available disposal means subject to quantity and quality permits. These interconnected standards, practices and permits shape the resulting environmental quality of the ecosystem under consideration. A fourth component, environmental indicators, of the SDM framework provides a measure of the ecosystem productivity and status that may differ based on societal values and culture. The four components of the SDM are interwoven into an outcome assessment process to form the management and feedback models. The concept of Sustainable Development is expressed in the management model as an objective function subject to desired constraints imposing the required bounds for achieving ecosystem sustainability. The development of the objective function and constrains requires monetary values for ecosystem functions, resources development activities and environmental cost. The

Environmentally sustainable transport in the CEI countries

International Nuclear Information System (INIS)

Thaler, R.; Wiederkehr, P.

2004-01-01

Moving people and freight in an environmentally sustainable manner that reduces environmental pollution and health hazards is a key challenge for transport and environment policies in Europe. Present mobility patterns of passenger and freight transport in Central and Eastern Europe do not correspond to the objectives of sustainable development. This paper presents the results of a transport futures study for the CEI region as a whole using backcasting methodology with long-term sustainability criteria to be met by 2030. Achieving environmentally sustainable transport (EST) doesn't mean less transport and mobility than we have today, but it means primarily maintaining a balanced modal split that results in less environmental and health impacts than it would be under projected future trends. Rail, trams, busses and new forms of flexible inter-modal public transport mobility would have to take a large share and rail transport for passenger and freight as well as inland shipping would have to be nearly doubled by 2030 while road freight could still increase if it is based on alternative fuels reducing its impacts. Technological advancements for passenger cars and lorries, fuels and infrastructure will play an important part to achieve EST, but also ''smart'' mobility management (e.g. transport avoidance, increasing load factors and modal shift), innovative mobility services and freight logistics would be critical. The implementation of these policies and strategies will require coherent and comprehensive packages of instruments and measures, including: economic instruments, regulatory instruments, changes in infrastructure investment, mobility management, information and education programmes as well as better integration of land use, transport and environment policies. Realising EST will provide new opportunities for businesses to develop and invest in innovative solutions for passenger and freight transport. Overall, achieving EST would constitute a net benefit for

E-waste: A Challenge for Sustainable Development

Directory of Open Access Journals (Sweden)

Md. Sahadat Hossain

2015-01-01

Conclusions. Sustainability is being prioritized for all development activities by integrating societal, economic, environmental, technological, cultural, and gender perspectives. Considering the adverse potential eco-toxicological impacts and diverse health effects of e-waste, an urgent global multilateral agreement is needed addressing its management (i.e., handling, storage, transportation, recycling, and final disposal, whether by land filling or incineration. Due to the global nature of the issue and the difficulty of establishing sustainable and environmentally sound processing of e-waste in low-income countries, multinational negotiation and collaboration is the only realistic solution. Furthermore, comprehensive global e-waste management and policies could help to off-set the hazards of e-waste and are the best approach for achieving sustainable development.

Sustainable development, challenges and priorities

International Nuclear Information System (INIS)

Soltani Arabshahi, S.

2003-01-01

This article primarily introduces a general overview of the concept of sustainable development along with its formation and expansion process. After defining the concept, followed by an analysis of certain principles on how s ustainable development management h as so far been implemented, some arguments against those principles are presented. The article emphasize on the fact that ever since the concept of sustainable development has emerged, highly industrialized countries perceived it as o nging development m erely in its materialistic sense, with little respect to preserving the nature. while developing countries are held responsible to cooperate, coordinate and act in with international directives on environment protection, industrialized countries, in addition to changing their production and consumption patterns, must be committed to provided financial resources and transfer the needed environmentally sound technologies the developing world. The author finally suggests an number of guidelines as to how sustainable development may be achieved Iran

Indicators for sustainable transport policy in Denmark - why, what and how?

DEFF Research Database (Denmark)

Gudmundsson, Henrik; Cornet, Yannick

in the Danish transport policy, using policy goals, sustainability indicators and performance measures. The paper represents a first step in the SUSTAIN project aiming to develop a framework for national sustainable transport planning. The paper will draw on analysis of experience with the development and use......Denmark and other countries have the ambition to move towards a sustainable transport system. However it is challenging to achieve and credibly demonstrate progress towards sustainability in transport. The paper will specify foundations for monitoring and reporting progress towards sustainability...... of sustainability indicators to report transport policy performance, in Europe, North America and other parts of the world. The experience will be connected to critical literature in the areas of sustainability theory, knowledge utilization, and implementation in order to identify challenges to overcome...

Exploring an innovative watershed management approach: From feasibility to sustainability

International Nuclear Information System (INIS)

Said, A.; Sehlke, G.; Stevens, D.K.; Sorensen, D.; Walker, W.; Hardy, T.; Glover, T.

2006-01-01

Watershed management is dedicated to solving watershed problems on a sustainable basis. Managing watershed development on a sustainable basis usually entails a balance between the needs of humans and nature, both in the present and in the future. From a watershed or water resources development basis, these problems can be classified into five general categories: lack of water quantity, deterioration in water quality, ecological impacts, weak public participation, and weak economic value. The first three categories can be combined to make up physical sustainability while the last two categories can be defined as social and economic sustainability. Therefore, integrated watershed management should be designed to achieve physical sustainability utilizing, to the greatest extent possible, public participation in an economically viable manner. This study demonstrates an innovative approach using scientific, social, and motivational feasibilities that can be used to improve watershed management. Scientific feasibility is tied to the nature of environmental problems and the scientific means to solve them. Social feasibility is associated with public participation. Motivational feasibility is related to economic stimulation for the stakeholders to take actions. The ecological impacts, lack of water quantity and deterioration in water quality are problems that need scientific means in order to improve watershed health. However, the implementation of these means is typically not achievable without the right public participation. In addition, public participation is typically accelerated by economic motivation for the stakeholders to use the resources in a manner that improves watershed health. The Big Lost River in south-central Idaho has been used as an illustration for implementing scientific, social and motivational feasibilities and in a manner that can achieve sustainability relative to water resources management. However, the same approach can be used elsewhere after

Exploring an innovative watershed management approach: From feasibility to sustainability

Energy Technology Data Exchange (ETDEWEB)

Said, A. [Department of Civil and Environmental Engineering, University of South Florida, Tampa, FL 33620 (United States); Sehlke, G. [Idaho National Laboratory, Idaho Falls, ID 83415 (United States); Stevens, D.K.; Sorensen, D.; Walker, W.; Hardy, T. [Civil and Environmental Department, Utah State University, Logan, UT 84321 (United States); Glover, T. [Economics Department, Utah State University, Logan, UT 84321 (United States)

2006-10-15

Watershed management is dedicated to solving watershed problems on a sustainable basis. Managing watershed development on a sustainable basis usually entails a balance between the needs of humans and nature, both in the present and in the future. From a watershed or water resources development basis, these problems can be classified into five general categories: lack of water quantity, deterioration in water quality, ecological impacts, weak public participation, and weak economic value. The first three categories can be combined to make up physical sustainability while the last two categories can be defined as social and economic sustainability. Therefore, integrated watershed management should be designed to achieve physical sustainability utilizing, to the greatest extent possible, public participation in an economically viable manner. This study demonstrates an innovative approach using scientific, social, and motivational feasibilities that can be used to improve watershed management. Scientific feasibility is tied to the nature of environmental problems and the scientific means to solve them. Social feasibility is associated with public participation. Motivational feasibility is related to economic stimulation for the stakeholders to take actions. The ecological impacts, lack of water quantity and deterioration in water quality are problems that need scientific means in order to improve watershed health. However, the implementation of these means is typically not achievable without the right public participation. In addition, public participation is typically accelerated by economic motivation for the stakeholders to use the resources in a manner that improves watershed health. The Big Lost River in south-central Idaho has been used as an illustration for implementing scientific, social and motivational feasibilities and in a manner that can achieve sustainability relative to water resources management. However, the same approach can be used elsewhere after

CAEP 2015 Academic Symposium: Current State and Recommendations to Achieve Adequate and Sustainable Funding for Emergency Medicine Academic Units.

Science.gov (United States)

Lang, Eddy S; Artz, Jennifer D; Wilkie, Ryan D; Stiell, Ian G; Topping, Claude; Belanger, François P; Afilalo, Marc; Renouf, Tia; Crocco, Anthony; Wyatt, Kelly; Christenson, Jim

2016-05-01

To describe the current state of academic emergency medicine (EM) funding in Canada and develop recommendations to grow and establish sustainable funding. A panel of eight leaders from different EM academic units was assembled. Using mixed methods (including a literature review, sharing of professional experiences, a survey of current EM academic heads, and data previously collected from an environmental scan), 10 recommendations were drafted and presented at an academic symposium. Attendee feedback was incorporated, and the second set of draft recommendations was further distributed to the Canadian Association Emergency Physicians (CAEP) Academic Section for additional comments before being finalized. Recommendations were developed around the funding challenges identified and solutions developed by academic EM university-based units across Canada. A strategic plan was seen as integral to achieving strong funding of an EM unit, especially when it aligned with departmental and institutional priorities. A business plan, although occasionally overlooked, was deemed an important component for planning and sustaining the academic mission. A number of recommendations surrounding philanthropy consisted of creating partnerships with existing foundations and engaging multiple stakeholders and communities. Synergy between academic and clinical EM departments was also viewed as an opportunity to ensure integration of common missions. Education and networking for current and future leaders were also viewed as invaluable to ensure that opportunities are optimized through strong leadership development and shared experiences to further the EM academic missions across the country. These recommendations were designed to improve the financial circumstances for many Canadian EM units. There is a considerable wealth of resources that can contribute to financial stability for an academic unit, and an annual networking meeting and continuing education on these issues will facilitate

Life-cycle design for sustainable architecture

Directory of Open Access Journals (Sweden)

Francesca Thiébat

2013-05-01

Full Text Available Sustainability in architecture should involve environmental and social aspects and also economic aspects. However, in a design process budget issues usually outweigh ecological aspects. How can we then drive clients and builders to put more socially responsible buildings on the market that do not exceed the fixed budget but are environmentally friendly? This paper propose an economic and environmental assessment tool to aid private or public building designers and owners to find the global sustainability value of a green building within a life cycle perspective. Sustainable life cycle tools for buildings design and construction help to achieve successfully integrated architecture. The research here presented proposes a new point of view of the “time-cost-quality triangle” of Project Management, by introducing three further aspects: environment, society and aesthetics.

Concepts for Life Cycle Cost Control Required to Achieve Space Transportation Affordability and Sustainability

Science.gov (United States)

Rhodes, Russel E.; Zapata, Edgar; Levack, Daniel J. H.; Robinson, John W.; Donahue, Benjamin B.

2009-01-01

Cost control must be implemented through the establishment of requirements and controlled continually by managing to these requirements. Cost control of the non-recurring side of life cycle cost has traditionally been implemented in both commercial and government programs. The government uses the budget process to implement this control. The commercial approach is to use a similar process of allocating the non-recurring cost to major elements of the program. This type of control generally manages through a work breakdown structure (WBS) by defining the major elements of the program. If the cost control is to be applied across the entire program life cycle cost (LCC), the approach must be addressed very differently. A functional breakdown structure (FBS) is defined and recommended. Use of a FBS provides the visibifity to allow the choice of an integrated solution reducing the cost of providing many different elements of like function. The different functional solutions that drive the hardware logistics, quantity of documentation, operational labor, reliability and maintainability balance, and total integration of the entire system from DDT&E through the life of the program must be fully defined, compared, and final decisions made among these competing solutions. The major drivers of recurring cost have been identified and are presented and discussed. The LCC requirements must be established and flowed down to provide control of LCC. This LCC control will require a structured rigid process similar to the one traditionally used to control weight/performance for space transportation systems throughout the entire program. It has been demonstrated over the last 30 years that without a firm requirement and methodically structured cost control, it is unlikely that affordable and sustainable space transportation system LCC will be achieved.

Renewable energy and environment ally sustainable development in Pakistan

International Nuclear Information System (INIS)

Harijan, K.; Memon, M.; Uqaili, M.A.

2005-01-01

In Pakistan, about two-thirds of the primary energy requirements are met through conventional sources while traditional biomass accounts the remaining one-third The primary commercial energy is largely based on fossil fuels. Indigenous reserves of oil and gas are limited and the coal available in the country is of poor quality. Environmental pollution and greenhouse gas emissions from energy use are becoming significant environmental issues in the country. Achieving solutions to these environmental problems requires long-term potential actions for sustainable development. In this regard, renewable energy resources appear to be one of the most efficient and effective solutions. Pakistan's geographical location has several advantages for extensive use of most of these renewable energy sources. This paper presents review of the present energy situation and environmental sustainability, and assesses the potential of renewable energy sources in Pakistan. Also, potential solutions to current environmental problems are identified along with renewable energy technologies. Several problems relating to renewable energy sources, environmentally sustainable development are discussed from both current and future perspectives. The present study shows that there is substantial potential of renewables in Pakistan. For achieving environmentally sustainable development, renewables must be developed and utilized. (author)

Shaping a sustainable energy future for India: Management challenges

International Nuclear Information System (INIS)

Bhattacharyya, Subhes C.

2010-01-01

Most of the studies on the Indian energy sector focus on the possible future scenarios of Indian energy system development without considering the management dimension to the problem-how to ensure a smooth transition to reach the desired future state. The purpose of this paper is to highlight some sector management concerns to a sustainable energy future in the country. The paper follows a deductive approach and reviews the present status and possible future energy outlooks from the existing literature. This is followed by a strategy outline to achieve long-term energy sustainability. Management challenges on the way to such a sustainable future are finally presented. The paper finds that the aspiration of becoming an economic powerhouse and the need to eradicate poverty will necessarily mean an increase in energy consumption unless a decoupling of energy and GDP growth is achieved. Consequently, the energy future of the country is eminently unsustainable. A strategy focussing on demand reduction, enhanced access, use of local resources and better management practices is proposed here. However, a sustainable path faces a number of challenges from the management and policy perspectives.

Entrepreneurship And Business Management - Exploring Linkages For Sustainable Development

Directory of Open Access Journals (Sweden)

Dr Serah K Mbetwa

2015-08-01

Full Text Available Entrepreneurs have emerged as market leaders in todays business world amidst the numerous economic turmoil constantly affecting economies on a global scale. This research paper is on entrepreneurship and business management and its linkages to other business stakeholders. The research paper therefore discusses entrepreneurship and business management exploring the linkages to available financing and potential institutions for startup capital by linking entrepreneurs to the government financiers and the public clientele. It is believed that this can bring about achievement of sustainable development goals translating into sustainable development and hence economic growth. The idea of funding is echoed by Robert Rice 2016 An entrepreneur without funding is like a musician with no instruments. Sustainability and entrepreneurship sustainopreneurship is made possible with availability of information on linkages between entrepreneurs and financial lending institutions as well as government policy. It is hoped that the research will add to the existing knowledge and help entrepreneurs with funding options for their business ideas to come to life. Findings show that the government financial lending institutions and the public are the major linkages between entrepreneurship and business management and are critical for attaining sustainable development goals and achieving economic growth.

Empirical Study on the Indicators of Sustainable Performance – the Sustainability Balanced Scorecard, Effect of Strategic Organizational Change

Directory of Open Access Journals (Sweden)

Maria Radu

2012-06-01

Full Text Available The sustainable organizational change has an ever increasing importance, leading to the rethinking of the management and systems of performance measurement and monitoring within the companies. As a reaction to current economic phenomena, in the first section of this work we tried to bring out the need for using the couple Balanced Scorecard - Corporate Social Responsibility by companies. Thus, companies involved in sustainable actions must grant a great importance to the impact of environmental, social and economic factors in providing added value, informing the interested parties and reflecting the reporting of sustainable performance. As a consequence, in the second part of the work we present the Sustainability Balanced Scorecard for the implementation of efficient strategies which cumulate the economic, social and environmental aspects as integrating system for sustainable performance and as a new challenge for organizational change. The key performance indicators included in the Sustainability Balanced Scorecard are quantified by the indicators of sustainable development, based on which the empirical research described in the third section of the work was achieved. Through the quantitative analysis of the economic and ecological indicators (Gross Domestic Product per capita, respective, Environmental Performance Index in correlation with the social indicator (Global Competitive Index, we conclude that the implementation of green strategies by companies leads to sustainable economic growth.

Multi-Sector Sustainability Browser (MSSB) User Manual: A ...

Science.gov (United States)

EPA’s Sustainable and Healthy Communities (SHC) Research Program is developing methodologies, resources, and tools to assist community members and local decision makers in implementing policy choices that facilitate sustainable approaches in managing their resources affecting the built environment, natural environment, and human health. In order to assist communities and decision makers in implementing sustainable practices, EPA is developing computer-based systems including models, databases, web tools, and web browsers to help communities decide upon approaches that support their desired outcomes. Communities need access to resources that will allow them to achieve their sustainability objectives through intelligent decisions in four key sustainability areas: • Land Use • Buildings and Infrastructure • Transportation • Materials Management (i.e., Municipal Solid Waste [MSW] processing and disposal) The Multi-Sector Sustainability Browser (MSSB) is designed to support sustainable decision-making for communities, local and regional planners, and policy and decision makers. Document is an EPA Technical Report, which is the user manual for the Multi-Sector Sustainability Browser (MSSB) tool. The purpose of the document is to provide basic guidance on use of the tool for users

Assessing the Value of Housing Schemes through Sustainable Return on Investment: A Path towards Sustainability-Led Evaluations?

Directory of Open Access Journals (Sweden)

Kevin Dean

2017-12-01

Full Text Available The 2016 United Nations (UN New Urban Agenda clearly reaffirms the concept that sustainable cities require intertwined environmental and social sustainability. The United Nations Sustainable Development Goal (SDG 11—“Make cities inclusive, safe, resilient, and sustainable”—sets (as a primary target the provision of sufficient affordable housing. Despite the central role that housing plays in ensuring sustainability and the importance of both environmental and social pillars in ensuring sustainable development, current evaluative methods that support decision making on social housing interventions fail to capture all of the socio-environmental value contained in the UN SDG 11. This paper addresses the issue by demonstrating how Sustainable Return on Investment can successfully describe and analyse a range of externalities related to the sustainable value generated by social housing regeneration schemes. To achieve this goal, a single case study strategy has been chosen. Two extant projects—a high-rise housing scheme and an environmental-led program developed by City West Housing Trust (a nonprofit housing association based in the Manchester area—have been assessed in order to monetise their social and environmental value through different methods. The findings show that, historically, the environmental and social value of regeneration schemes have been largely disregarded because of a gap in the evaluation methods, and that there is room for significant improvement for future evaluation exercises.

SUSTAINABLE DEVELOPMENT – HUMAN DEVELOPMENT CONNECTIONS IN THE POST-TRUTH ERA

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ANDREEA CONSTANTINESCU

2017-08-01

Full Text Available Following the distancing of current policy from economic rigors and ethical demands aimed at redistribution of wealth, modern societies are parasitized by post-truth of actual facts. It distorts the shape and content of general interest data, for example political distortion of scientific evidence proving anthropogenic climate change. Under these circumstances, the question "to what extent economist’s truth stating what you cannot measure you cannot manage is sustained?" becomes absolutely legitimate. Regarding sustainable development management, monitoring the degree of achievement of Sustainable Development Goals is no longer sufficient to track progress in this area. Therefore, experts propose to introduce as much as possible qualitative data which, combined with quantitative data, will enhance their relevance and make them harder to be diverted for political purposes. This paper follows this direction, trying to prove that protection of data’s real meaning can be achieved by systemic analysis of all data originating from monitoring certain processes, which can be aggregated, with applicability in sustainable development. Thus, analyzing together data on sustainable development and those that indicates the state of human development emphasizes on one hand, the intrinsic link between these concepts and, on the other, maintain the sense of sustainability even in the post-truth era.

The Importance of Industrial Ecology in Engineering Education for Sustainable Development

Science.gov (United States)

Biswas, Wahidul K.

2012-01-01

Purpose: The purpose of this paper is to show how industrial ecology can facilitate the achievement of sustainable development through its incorporation into an engineering curriculum. Design/methodology/approach: A model has been developed for assessing sustainability learning outcomes due to the incorporation of the concept of industrial ecology…

A proposal to measure absolute environmental sustainability in lifecycle assessment

DEFF Research Database (Denmark)

Bjørn, Anders; Margni, Manuele; Roy, Pierre-Olivier

2016-01-01

sustainable are therefore increasingly important. Such absolute indicators exist, but suffer from shortcomings such as incomplete coverage of environmental issues, varying data quality and varying or insufficient spatial resolution. The purpose of this article is to demonstrate that life cycle assessment (LCA...... in supporting decisions aimed at simultaneously reducing environmental impacts efficiently and maintaining or achieving environmental sustainability. We have demonstrated that LCA indicators can be modified from being relative to being absolute indicators of environmental sustainability. Further research should...

The Role of Ethiopia's Public Universities in Achieving the United Nations Sustainable Development Goals

Science.gov (United States)

O'Keeffe, Paul

2016-01-01

In recent years, the Ethiopian government has embarked on an ambitious agriculture development strategy aimed at raising Ethiopia to the status of a middle-income-level country by 2025. Encouraged by the international development push behind the United Nations Sustainable Development Goals (SDGs), the rapid expansion of public universities has…

Natural Resources Accounting and Sustainable Development: The ...

African Journals Online (AJOL)

Natural Resources Accounting and Sustainable Development: The Challenge to Economics and Accounting Profession. ... African Research Review ... The approach used in achieving this objective is by identifying the present position, limitations and the challenges for the economics and accounting professions.

Achieving sustainable irrigation water withdrawals: global impacts on food security and land use

Science.gov (United States)

Liu, Jing; Hertel, Thomas W.; Lammers, Richard B.; Prusevich, Alexander; Baldos, Uris Lantz C.; Grogan, Danielle S.; Frolking, Steve

2017-10-01

Unsustainable water use challenges the capacity of water resources to ensure food security and continued growth of the economy. Adaptation policies targeting future water security can easily overlook its interaction with other sustainability metrics and unanticipated local responses to the larger-scale policy interventions. Using a global partial equilibrium grid-resolving model SIMPLE-G, and coupling it with the global Water Balance Model, we simulate the consequences of reducing unsustainable irrigation for food security, land use change, and terrestrial carbon. A variety of future (2050) scenarios are considered that interact irrigation productivity with two policy interventions— inter-basin water transfers and international commodity market integration. We find that pursuing sustainable irrigation may erode other development and environmental goals due to higher food prices and cropland expansion. This results in over 800 000 more undernourished people and 0.87 GtC additional emissions. Faster total factor productivity growth in irrigated sectors will encourage more aggressive irrigation water use in the basins where irrigation vulnerability is expected to be reduced by inter-basin water transfer. By allowing for a systematic comparison of these alternative adaptations to future irrigation vulnerability, the global gridded modeling approach offers unique insights into the multiscale nature of the water scarcity challenge.

Sustainable Urban Transport Planning

Directory of Open Access Journals (Sweden)

Boitor Melania R.

2013-07-01

Full Text Available Environmental protection has become a common issue in every area, but extremely important for the domains which deal with intensive energy consumption as it is the case of the transportation. Achieving the sustainable cities on the other hand, is also focused on the protection of the environment in order to provide a higher quality of life for the population. Therefore it is considered that by improving the urban transportation planning additional benefits could be provided for both the environment and the sustainable development of the cities. One possibility is to supplement the traditionally land-use plans with the transportrelated zones analysis, where the city is divided in public transport, pedestrian and caroriented zones. Analyzing the transport-related zones of a city is important as it provides additional information in the assessment of the development trend. The process of zoning was conducted for the city of Cluj-Napoca, Romania. In this paper, the outcome of the zoning was analyzed for a more comprehensive review of the urban transport in order to attain a sustainable-oriented approach of the urban area development.

If Development, Then Sustainability

Directory of Open Access Journals (Sweden)

Bóna Péter

2015-12-01

Full Text Available The aim of this study is to explore how the effects of components belonging to the concept of strategic management system influence outstanding achievement and success in the processing industry in Hungary as well as the sustainability success component within that. In order to do that, the study defines the factors having an influence. Thereafter, it explains the successful operation of companies with the help of factors emerging via path analysis using regression models. It uses the balanced scorecard as a tool for success criteria describing success. This is a non-market aspect that has an impact on the whole system, making it of crucial importance. Via the exploration of effects, it can be shown the deliberate use of those factors that generate outstanding results and success from the point of view of sustainability, and thus internal development, customer appreciation, and financial success. By taking the results of the research into consideration, it will also be revealed that success factors in the processing industry in Hungary have the most direct and the largest impact on outstanding sustainability performance.

Advancing sustainable development in Canada : policy issues and research needs

International Nuclear Information System (INIS)

Eliadis, P.; Slayen, S.

2003-11-01

This paper defined 7 policy-relevant issues that advance sustainable development in Canada. These were; (1) urban redesign, (2) freshwater management, (3) eco-region sustainability, (4) impacts of globalization on sustainable development in Canada, (5) designing signals and incentives that promote sustainable behaviour among citizens, (6) reducing the ecological burden of unsustainable lifestyles, and (7) international engagement in sustainable development. The authors questioned why these issues have not made greater progress, given that they have been on national and international agendas since 1972. They also questioned why it is so difficult to integrate environmental and economic signals. Finally, they examined whether enough ecological and political space can be provided to developing countries to achieve sustainable development while enhancing the standard of living in Canada and not threatening critical global systems. 173 refs

Indicators of sustainable capacity building for health research: analysis of four African case studies.

Science.gov (United States)

Bates, Imelda; Taegtmeyer, Miriam; Squire, S Bertel; Ansong, Daniel; Nhlema-Simwaka, Bertha; Baba, Amuda; Theobald, Sally

2011-03-28

Despite substantial investment in health capacity building in developing countries, evaluations of capacity building effectiveness are scarce. By analysing projects in Africa that had successfully built sustainable capacity, we aimed to identify evidence that could indicate that capacity building was likely to be sustainable. Four projects were selected as case studies using pre-determined criteria, including the achievement of sustainable capacity. By mapping the capacity building activities in each case study onto a framework previously used for evaluating health research capacity in Ghana, we were able to identify activities that were common to all projects. We used these activities to derive indicators which could be used in other projects to monitor progress towards building sustainable research capacity. Indicators of sustainable capacity building increased in complexity as projects matured and included- early engagement of stakeholders; explicit plans for scale up; strategies for influencing policies; quality assessments (awareness and experiential stages)- improved resources; institutionalisation of activities; innovation (expansion stage)- funding for core activities secured; management and decision-making led by southern partners (consolidation stage).Projects became sustainable after a median of 66 months. The main challenges to achieving sustainability were high turnover of staff and stakeholders, and difficulties in embedding new activities into existing systems, securing funding and influencing policy development. Our indicators of sustainable capacity building need to be tested prospectively in a variety of projects to assess their usefulness. For each project the evidence required to show that indicators have been achieved should evolve with the project and they should be determined prospectively in collaboration with stakeholders.

Social Science, Equity and the Sustainable Development Goals

Science.gov (United States)

Liverman, D.

2015-12-01

The Sustainable Development Goals are underpinned by a committment to a world that is just, equitable, inclusive and environmentally sustainable and include goals of ending poverty and hunger; universal access to health, education, water, sanitation, energy and decent work; and reducing the risks and impacts of climate change, biodiversity loss, and marine, forest and land degradation. They seek to reduce inequality between and within countries and achieve gender equality. The SDGs build on the apparent success in meeting many of the Millenium Development Goals, including those of reducing poverty, hunger and debt and providing access to water. The science needed to achieve and monitor most of these goals is social science - an area of scholarship that is traditionally undervalued, underfunded, underepresented misunderstood and lacking in detailed data. This paper will provide an overview of the social science that is needed to support the Sustainable Development Goals, with a particular focus on the challenges of monitoring social data over time and within countries, the importance of research design, and of building capacity and credibility in the social sciences. As an example, the paper will discuss the social science that will be needed to achieve Goal 13: Take urgent actions to combat climate change and its impacts, and measuring targets such as strengthening resilience and adaptive capacity, and raising capacities of women, youth, and marginalized communities to manage and respond climate change.

Recent trends in air transport sustainibility

Energy Technology Data Exchange (ETDEWEB)

Benito, A.; Alonso, G.

2016-07-01

The target of this paper is to analyse the main elements of Air Transport sustainability, studying their evolution during the last years and establishing the future prevalent trends, which might be modified by the application of the adequate policies. Air Transport sustainability is considered as integrated by five basic characteristics: physical accessibility, economic affordability, safety, security and environmental impact. Each one of them has its own influence on the development of this transportation mode and all of them are required in order to achieve a sustainable development. After defining the structural elements of the five characteristics and the corresponding quantitative indicators, the paper studies the recent evolution of such indicators and extrapolates the most likely future trends, having taken into account the most relevant limitations presently existent or potentially appearing in the near future. The most important policies being presently studied (future aircraft designs, infrastructure developments, potential safety and security new rules and tentative environmental action programs) are evaluated, considering the potential repercussions on sustainability progress. Some combinations of them are suggested as the most efficient alternatives for preserving the sustainable development of XXI century air transport. (Author)

Energy sustainability: consumption, efficiency, and environmental impact

Science.gov (United States)

One of the critical challenges in achieving sustainability is finding a way to meet the energy consumption needs of a growing population in the face of increasing economic prosperity and finite resources. According to ecological footprint computations, the global resource consump...

Nuclear energy sustainable development and public awareness

International Nuclear Information System (INIS)

Murty, G.S.

2001-01-01

This paper provides the latest information about the importance of energy needs and its growth in the years to come, the role of the nuclear energy and the need for public awareness and acceptability of the programs to achieve sustainable development

A multilevel evolutionary framework for sustainability analysis

Directory of Open Access Journals (Sweden)

Timothy M. Waring

2015-06-01

Full Text Available Sustainability theory can help achieve desirable social-ecological states by generalizing lessons across contexts and improving the design of sustainability interventions. To accomplish these goals, we argue that theory in sustainability science must (1 explain the emergence and persistence of social-ecological states, (2 account for endogenous cultural change, (3 incorporate cooperation dynamics, and (4 address the complexities of multilevel social-ecological interactions. We suggest that cultural evolutionary theory broadly, and cultural multilevel selection in particular, can improve on these fronts. We outline a multilevel evolutionary framework for describing social-ecological change and detail how multilevel cooperative dynamics can determine outcomes in environmental dilemmas. We show how this framework complements existing sustainability frameworks with a description of the emergence and persistence of sustainable institutions and behavior, a means to generalize causal patterns across social-ecological contexts, and a heuristic for designing and evaluating effective sustainability interventions. We support these assertions with case examples from developed and developing countries in which we track cooperative change at multiple levels of social organization as they impact social-ecological outcomes. Finally, we make suggestions for further theoretical development, empirical testing, and application.

Nuclear Symbiosis - A Means to Achieve Sustainable Nuclear Growth While Limiting the Spread of Sensitive Nuclear Technology

International Nuclear Information System (INIS)

Shropshire, David

2009-01-01

Global growth of nuclear energy in the 21. century is creating new challenges to limit the spread of nuclear technology without hindering adoption in countries now considering nuclear power. Independent nuclear states desire autonomy over energy choices and seek energy independence. However, this independence comes with high costs for development of new indigenous fuel cycle capabilities. Nuclear supplier states and expert groups have proposed fuel supply assurance mechanisms such as fuel take-back services, international enrichment services and fuel banks in exchange for recipient state concessions on the development of sensitive technologies. Recipient states are slow to accept any concessions to their rights under the Non Proliferation Treaty. To date, decisions to not develop indigenous fuel enrichment capabilities have been driven by economics. However, additional incentives may be required in the future to offset the user state's perceived loss of energy independence. In order for a country to forgo development of sensitive nuclear capabilities, the basis for an equitable economic tradeoff must be established. This paper proposes that the nuclear trade-off can be made through a combination of fuel supply assurances, leveraging work by the United Nations and International Atomic Energy Agency on sustainable nuclear development, and use of 'nuclear symbiosis'. The primary focus of this paper is on how nuclear symbiosis could be used to achieve a user-state's desired economic, energy, and infrastructure development end states. The desired result from this 'symbiosis' is a nuclear-centered industrial complex that creates new economic opportunities through infrastructure improvements, human resource skills development and the development of new sustainable industries. This paper also describes the Nuclear Materials Exchange (NME) as a practical tool for performing nuclear symbiosis. The NME can be used to define existing and new international nuclear resources and

Towards Sustainable Development

DEFF Research Database (Denmark)

Silva, Victor

2010-01-01

GHG emissions can be reduced by shifting travel to a more efficient mode, which can be achieved by offering high quality public transport integrated to land use and density policies. However, there is a scarcity of efficient and low-cost alternatives to improve urban transport and tackle GHG emis......). The review highlights empirical evidence of the development and implementation of creative solutions, which integrate transport infrastructure, land use policies and street design strategies for fostering sustainable mobility and GHG emission reduction....

PUBLIC DEBT ANALYSIS BASED ON SUSTAINABILITY INDICATORS

Directory of Open Access Journals (Sweden)

Elena DASCALU

2016-09-01

Full Text Available This article is an analysis of public debt, in terms of sustainability and vulnerability indicators, under a functioning market economy. The problems encountered regarding the high level of public debt or the potential risks of budgetary pressure converge to the idea that sustainability of public finances should be a major challenge for public policy. Thus, the policy adequate to address public finance sustainability must have as its starting point the overall strategy of the European Union, as well as the economic development of Member States, focusing on the most important performance components, namely, reducing public debt levels, increasing productivity and employment and, last but not the least, reforming social security systems. In order to achieve sustainable levels of public debt, the European Union Member States are required to establish and accomplish medium term strategic budgetary goals to ensure a downward trend in public debt.

The role of meat in strategies to achieve a sustainable diet lower in greenhouse gas emissions: A review.

Science.gov (United States)

Hyland, John J; Henchion, Maeve; McCarthy, Mary; McCarthy, Sinéad N

2017-10-01

Food consumption is responsible for a considerable proportion of greenhouse gas emissions (GHGE). Hence, individual food choices have the potential to substantially influence both public health and the environment. Meat and animal products are relatively high in GHGE and therefore targeted in efforts to reduce dietary emissions. This review first highlights the complexities regarding sustainability in terms of meat consumption and thereafter discusses possible strategies that could be implemented to mitigate its climatic impact. It outlines how sustainable diets are possible without the elimination of meat. For instance, overconsumption of food in general, beyond our nutritional requirements, was found to be a significant contributor of emissions. Non-voluntary and voluntary mitigation strategies offer potential to reduce dietary GHGE. All mitigation strategies require careful consideration but on-farm sustainable intensification perhaps offers the most promise. However, a balance between supply and demand approaches is encouraged. Health should remain the overarching principle for policies and strategies concerned with shifting consumer behaviour towards sustainable diets. Copyright © 2017. Published by Elsevier Ltd.

Energy indicators for sustainable development

International Nuclear Information System (INIS)

Vera, Ivan; Langlois, Lucille

2007-01-01

Energy is an essential factor in overall efforts to achieve sustainable development. Countries striving to this end are seeking to reassess their energy systems with a view toward planning energy programmes and strategies in line with sustainable development goals and objectives. This paper summarizes the outcome of an international partnership initiative on indicators for sustainable energy development that aims to provide an analytical tool for assessing current energy production and use patterns at a national level. The proposed set of energy indicators represents a first step of a consensus reached on this subject by five international agencies-two from the United Nations system (the Department of Economic and Social Affairs and the International Atomic Energy Agency), two from the European Union (Eurostat and the European Environment Agency) and one from the Organization for Economic Cooperation and Development (the International Energy Agency). Energy and environmental experts including statisticians, analysts, policy makers and academics have started to implement general guidelines and methodologies in the development of national energy indicators for use in their efforts to monitor the effects of energy policies on the social, economic and environmental dimensions of sustainable development

A Blueprint for Innovation to Achieve Health System Transformation.

Science.gov (United States)

Snowdon, Anne W

2017-01-01

Global health systems are challenged by escalating costs and growing demands for care created by the demands of aging populations and rising rates of chronic illness which place unsustainable pressure on health systems to meet population health needs. To overcome these challenges, transformational change is needed to strengthen health system performance and sustainability. Innovation is widely viewed as the strategy to drive transformational change in health systems; yet to date, innovation has lacked a clearly defined focus or agenda to achieve transformation. An actionable innovation agenda is needed to achieve transformational change for health systems. The key conditions for success as an innovation strategy are examined, including clearly defined innovation objectives, key milestones, and actionable steps every system stakeholder must pursue in order to guide the innovation agenda and ultimately accelerate the transformational changes needed for a sustainable healthcare system that delivers value to populations.

“DOSSA”, highway to energy self-sustainability

International Nuclear Information System (INIS)

Abejon Aparicio, Noe; Lai, Cynthia; Chan-Halbrendt, Catherine

2012-01-01

Highlights: ► We present a new model to achieve zero energy emissions. ► We compared with the strategic plan implemented by the University of Hawai’i at Manoa. ► Comparison scenarios are created using projections of the involved 13 variables. ► The most probable three projections are used for each variable. ► DOSSA reaches energy institutional self-sustainability an average of 23 years earlier. -- Abstract: Emphasis has been put forth in the field of applied energy towards reducing consumption, using renewable energy sources and mitigating pollution and greenhouse gas emissions. Although these strategies are striving to achieve the same goal, there is no logical model that clearly establishes their pathway to success; therefore, DOSSA, a new and innovative model, has been developed to provide this necessary central bridge of multiple pathways through five easy and adaptable steps: (1) Data inventory; (2) Objectives; (3) Staff/Committee; (4) Strategy; and (5) Accountability (DOSSA). In this study, the DOSSA model was applied and compared to the University of Hawai’i at Manoa’s (UHM’s) current strategic energy plan: to achieve zero emissions in terms of energy by the year 2050. Under proper execution of each step from the model, this study shows the effectiveness of the application of DOSSA to any goal or objective by increasing efficiency and creative and innovative approaches to problems, specifically, environmental initiatives. Through the application of DOSSA in this case study at UHM, it was projected that UHM has the potential to be completely self-sustainable in terms of energy consumption approximately 23 years earlier to its expected “strategic plan” date of 2050. Thus, DOSSA cannot only be used as an instigator for achieving reduction goals but also as an accelerator for various green initiatives – a highway to energy self-sustainability.

The sustainable project management: A review and future possibilities

Directory of Open Access Journals (Sweden)

V.K. Chawla

2018-06-01

Full Text Available Sustainability in project operations such as financial, social and environmental sustainability is one of the most prominent issues of the present times to address. The increased focus on sus-tainable business operations has changed the viewpoint of researchers and corporate community towards the project management. Today sustainability in business operations along with sustain-ability of natural and environmental resources are of paramount significance which has further caused a huge impact on conception, planning, scheduling and execution of the project manage-ment activities. In this paper, a literature review between 1987 and 2018 on different issues af-fecting the sustainability in project management is carried out. The present study also identifies and discusses the future possibilities to apply computational procedures in order to estimate and optimize the sustainability issues in the management of projects, for example the computational evolutionary algorithms can be applied to formulate the multi-objective decision-making problem after considering critical factors of sustainability in the projects and then yielding optimized solu-tions for the formulated problem to achieve sustainability in the projects. A new integrated framework with the inclusion of feedback function for assessment of each decision and actions taken towards the sustainability of the projects is also identified and presented.

Public spaces and urban sustainability in the tropical built environment

Science.gov (United States)

Yusof, Y. M.; Kozlowski, M.

2018-01-01

Sustainability is an overarching sense of responsibility towards the future. On a city-wide level, urban sustainability incorporates a wide body of changes especially as they relate to the built environment, all of which intended at creating a livable place. This paper discusses existing public spaces in view of their achievement against a set of criteria for the built environment. The paper introduces performance design criteria for the tropical built environment. The key findings indicate that long-term strategies, guidance and directions for the city and region can achieve development which corresponds to local climate, synergies and provide a higher proportion of public spaces that offer something for everyone.

No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells.

Science.gov (United States)

Steinkellner, Hannes; Singh, Himanshu Narayan; Muckenthaler, Martina U; Goldenberg, Hans; Moganty, Rajeswari R; Scheiber-Mojdehkar, Barbara; Sturm, Brigitte

2017-07-20

Friedreich's ataxia (FRDA) is a neurodegenerative disease caused by reduced expression of the protein frataxin. Frataxin is thought to play a role in iron-sulfur cluster biogenesis and heme synthesis. In this study, we used erythroid progenitor stem cells obtained from FRDA patients and healthy donors to investigate the putative role, if any, of frataxin deficiency in heme synthesis. We used electrochemiluminescence and qRT-PCR for frataxin protein and mRNA quantification. We used atomic absorption spectrophotometry for iron levels and a photometric assay for hemoglobin levels. Protoporphyrin IX and Ferrochelatase were analyzed using auto-fluorescence. An "IronChip" microarray analysis followed by a protein-protein interaction analysis was performed. FRDA patient cells showed no significant changes in iron levels, hemoglobin synthesis, protoporphyrin IX levels, and ferrochelatase activity. Microarray analysis presented 11 genes that were significantly changed in all patients compared to controls. The genes are especially involved in oxidative stress, iron homeostasis and angiogenesis. The mystery about the involvement of frataxin on iron metabolism raises the question why frataxin deficiency in primary FRDA cells did not lead to changes in biochemical parameters of heme synthesis. It seems that alternative pathways can circumvent the impact of frataxin deficiency on heme synthesis. We show for the first time in primary FRDA patient cells that reduced frataxin levels are still sufficient for heme synthesis and possibly other mechanisms can overcome reduced frataxin levels in this process. Our data strongly support the fact that so far no anemia in FRDA patients was reported. Copyright © 2017 Elsevier B.V. All rights reserved.

Identifying Hotspots in Land and Water Resource Uses on the Way towards Achieving the Sustainable Development Goals

Science.gov (United States)

Palazzo, A.; Havlik, P.; Van Dijk, M.; Leclere, D.

2017-12-01

Agriculture plays a key role in achieving adequate food, water, and energy security (as summarized in the Sustainable Development Goals SDGs) as populations grow and incomes rise. Yet, agriculture is confronted with an enormous challenge to produce more using less. Land and water resources are projected to be strongly affected by climate change demand and agriculture faces growing competition in the demand for these resources. To formulate policies that contribute to achieving the SDGs, policy makers need assessments that can anticipate and navigate the trade-offs within the water/land/energy domain. Assessments that identify locations or hotspots where trade-offs between the multiple, competing users of resources may exist must consider both the local scale impacts of resource use as well as regional scale socioeconomic trends, policies, and international markets that further contribute to or mitigate the impacts of resource trade-offs. In this study, we quantify impacts of increased pressure on the land system to provide agricultural and bioenergy products under increasingly scarce water resources using a global economic and land use model, GLOBIOM. We model the supply and demand of agricultural products at a high spatial resolution in an integrated approach that considers the impacts of global change (socioeconomic and climatic) on the biophysical availability and the growing competition of land and water. We also developed a biodiversity module that relates changes in land uses to changes in local species richness and global species extinction risk. We find that water available for agriculture and freshwater ecosystems decreases due to climate change and growing demand from other sectors (domestic, energy and industry) (Fig 1). Climate change impacts will limit areas suitable for irrigation and may lead to an expansion of rainfed areas in biodiverse areas. Impacts on food security from climate change are significant in some regions (SSA and SA) and policies

How to achieve optimal and sustainable use of the subsurface for Aquifer Thermal Energy Storage

International Nuclear Information System (INIS)

Bloemendal, Martin; Olsthoorn, Theo; Boons, Frank

2014-01-01

A heat pump combined with Aquifer Thermal Energy Storage (ATES) has high potential in efficiently and sustainably providing thermal energy for space heating and cooling. This makes the subsurface, including its groundwater, of crucial importance for primary energy savings. The regulation of ATES systems is similar in many countries around the world. This paper seeks solutions for the institutional hindrances to the diffusion of ATES. The use of aquifers by individual ATES systems can be optimized to maximize their efficiency on the one hand, and to optimize the performance of the regional subsurface for energy storage on the other. The application of ATES in an aquifer has similar properties as other common resource pool problems. Only with detailed information and feedback about the actual subsurface status, a network of ATES systems can work towards an optimum for both the subsurface and buildings, instead of striving for a local optimum for individual buildings. Future governance of the subsurface may include the self-organization or self-governance. For that the ATES systems need a complementary framework; interpretation of interaction, feedback and adaptable and dynamic control interpretations are the key elements for the optimal and sustainable use of the subsurface. - Highlights: • We show that ATES systems are not using the subsurface optimally and sustainably. • We elaborate how current legislation will not be able to overcome this problem. • We present self-organization as a perspective for governance of ATES systems

The Challenge of Implementing the Sustainable Development Goals ...

African Journals Online (AJOL)

AJRH Managing Editor

(local authorities, government agencies, private sector, and civil .... financing and service delivery gaps to achieve the goals. The private .... agenda needs not only to pay attention to ... Leach M (ed) (2015) Gender equality and sustainable.

Sustainable Urban Development – Compact Cities or Consumer Practices?

DEFF Research Database (Denmark)

Jensen, Jesper Ole; Christensen, Toke Haunstrup; Gram-Hanssen, Kirsten

2011-01-01

Sustainability in urban planning has a long history and it has been a widespread solution to build high and compact in order to minimise the need for transportation, land use and heating. Recent research, however, points towards the need for a supplementary approach, which includes the consumer...... behaviour of the household. This approach necessarily has to work from below and include the citizens, as it is their daily practices that have to be challenged. This article reviews selected literature and studies on whether compact cities leads to more sustainable cities, and it use lifestyle...... strategies of achieving sustainable urban development....

SUSTAINABLE ECONOMIC GROWTH THROUGH EXTERNAL TRADE

Directory of Open Access Journals (Sweden)

Valentina Vasile

2016-12-01

Full Text Available A country’s economic growth is directly influenced by the external trade activity, which is considered by the majority of economists as one of the main engines of a country. How international trade can contributes to a sustainable development of a country depends broadly on the economic policies as well as on global and regional strategies to support the actions for this objective. The high level political meeting of United Nations Organization’s Member States in September 2015 has as aim the adoption of 2030 Agenda for Sustainable Development, which includes global economic, social and environmental goals. Any strategy or global policy influences, of course, in a direct way the international trade activities, by how these measures affect or determine relations between states to achieve the sustainable development objectives. Being involved in all sectors of economic and social life to achieve these noble goals, foreign trade is of course on the list of key areas as well as on the list of the domains being influenced by the global strategy adopted in the framework of the largest summit of its kind in the history of the United Nations. The aim of this paper is to provide an overview of external trade activity of Romania, taking into account the characteristics of companies involved in exports and imports of goods in Romania as well as to identify the key areas to be further developed for a sustainable development of national economy based on export activity. Romania's sustainable development can be achieved in the medium and long term by complementary and converging actions such as increased expenditure on research and development field, attracting as a priority the Greenfield investments, increasing productivity of national capital (human, natural, technological or ensure the efficiency at microeconomic and macroeconomic level. Increasing the share of products and activities using a small amount of energy and material resources but which

Challenges to achieving sustainable sanitation in informal settlements of Kigali, Rwanda.

Science.gov (United States)

Tsinda, Aime; Abbott, Pamela; Pedley, Steve; Charles, Katrina; Adogo, Jane; Okurut, Kenan; Chenoweth, Jonathan

2013-12-10

Like most cities in developing countries, Kigali is experiencing rapid urbanisation leading to an increase in the urban population and rapid growth in the size and number of informal settlements. More than 60% of the city's population resides in these settlements, where they experience inadequate and poor quality urban services including sanitation. This article discusses the issues and constraints related to the provision of sustainable sanitation in the informal settlements in Kigali. Two informal settlements (Gatsata and Kimisagara) were selected for the study, which used a mixed method approach for data collection. The research found that residents experienced multiple problems because of poor sanitation and that the main barrier to improved sanitation was cost. Findings from this study can be used by the city authorities in the planning of effective sanitation intervention strategies for communities in informal settlements.

Transport Canada's sustainable development action plan

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-09-30

Transport Canada's sustainable development strategy, tabled in the House of Commons in December 1997, sets out the direction for the Department to integrate environmental concerns with safety and efficiency in developing policies and programs and in carrying out its day-to-day activities. While recognizing that moving towards sustainable development is a long-term undertaking, the department is determined to turn 'words' into 'work'. The action plan outlined in this document is organized according to the challenges laid out in the original Sustainable Development Strategy document. Accordingly, the department shall endeavour to minimize risk of environmental damage from transportation accidents; promote greening of operations in the transportation sector; reduce emissions of hazardous substances from transportation sources; promote education and awareness on sustainable transportation; refine sustainable performance indicators; and develop and promote the application of cleaner transportation systems and transportation technologies. The bulk of the report is devoted to brief summaries of progress achieved in each of these areas to date.

Day one sustainability

Science.gov (United States)

Orr, John; Ibell, Timothy; Evernden, Mark; Darby, Antony

2015-05-01

Emissions reductions targets for the UK set out in the Climate Change Act for the period to 2050 will only be achieved with significant changes to the built environment, which is currently estimated to account for 50% of the UK's carbon emissions. The socio-technological nature of Civil Engineering means that this field is uniquely placed to lead the UK through such adaptations. This paper discusses the importance of interdisciplinary teaching to produce multi-faceted team approaches to sustainable design solutions. Methods for measuring success in education are often not fit for purpose, producing good students but poor engineers. Real-world failures to apply sustainable design present a serious, difficult to detect, and ultimately economically negative situation. Techniques to replace summative examinations are presented and discussed, with the aim of enhancing core technical skills alongside those required for sustainable design. Finally, the role of our future engineers in policy-making is discussed. In addition to carbon, the provision of water and food will heavily influence the work of civil engineers in the coming decades. Leadership from civil engineers with the technical knowledge and social awareness to tackle these issues will be required. This provides both opportunities and challenges for engineering education in the UK.

Pathways to achieve a set of ambitious global sustainability objectives by 2050 : Explorations using the IMAGE integrated assessment model

NARCIS (Netherlands)

van Vuuren, Detlef P.; Kok, Marcel; Lucas, Paul L.; Prins, Anne Gerdien; Alkemade, Rob; van den Berg, Maurits; Bouwman, Lex; van der Esch, Stefan; Jeuken, Michel; Kram, Tom; Stehfest, Elke

2015-01-01

In 2012, governments worldwide renewed their commitments to a more sustainable development that would eradicate poverty, halt climate change and conserve ecosystems, and initiated a process to create a long-term vision by formulating Sustainable Development Goals (SDGs). Although progress in

Rethinking debt sustainability in the context of the Millennium Development Goals

Directory of Open Access Journals (Sweden)

Jan Kregel

2007-09-01

Full Text Available The 2005 World Summit Outcome (United Nations, General Assembly 2005b, pp. 7-8 noted that debt relief can be an important source of capital for development. Since debt relief for developing countries is currently determined by assessments of what is considered a sustainable external debt burden, it underlined the importance of debt sustainability to the efforts to achieve national development goals, including the Millennium Development Goals (MDGs. It also called for the preparation and implementation in 2006 of national development strategies (NDS to achieve the internationally agreed development goals and objectives, including the Millennium Development Goals

Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.

Science.gov (United States)

Di Tullio, Alessandro; Passaro, Diana; Rouault-Pierre, Kevin; Purewal, Sukhveer; Bonnet, Dominique

2017-07-11

Nuclear factor erythroid-derived 2 (NF-E2) has been associated with megakaryocyte maturation and platelet production. Recently, an increased in NF-E2 activity has been implicated in myeloproliferative neoplasms. Here, we investigate the role of NF-E2 in normal human hematopoiesis. Knockdown of NF-E2 in the hematopoietic stem and progenitor cells (HSPCs) not only reduced the formation of megakaryocytes but also drastically impaired hematopoietic stem cell activity, decreasing human engraftment in immunodeficient (NSG) mice. This phenotype is likely to be related to both increased cell proliferation (p21-mediated) and reduced Notch1 protein expression, which favors HSPC differentiation over self-renewal. Strikingly, although NF-E2 silencing in HSPCs did not affect their myeloid and B cell differentiation in vivo, it almost abrogated T cell production in primary hosts, as confirmed by in vitro studies. This effect is at least partly due to Notch1 downregulation in NF-E2-silenced HSPCs. Together these data reveal that NF-E2 is an important driver of human hematopoietic stem cell maintenance and T lineage differentiation. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation

Directory of Open Access Journals (Sweden)

Alessandro Di Tullio

2017-07-01

Full Text Available Nuclear factor erythroid-derived 2 (NF-E2 has been associated with megakaryocyte maturation and platelet production. Recently, an increased in NF-E2 activity has been implicated in myeloproliferative neoplasms. Here, we investigate the role of NF-E2 in normal human hematopoiesis. Knockdown of NF-E2 in the hematopoietic stem and progenitor cells (HSPCs not only reduced the formation of megakaryocytes but also drastically impaired hematopoietic stem cell activity, decreasing human engraftment in immunodeficient (NSG mice. This phenotype is likely to be related to both increased cell proliferation (p21-mediated and reduced Notch1 protein expression, which favors HSPC differentiation over self-renewal. Strikingly, although NF-E2 silencing in HSPCs did not affect their myeloid and B cell differentiation in vivo, it almost abrogated T cell production in primary hosts, as confirmed by in vitro studies. This effect is at least partly due to Notch1 downregulation in NF-E2-silenced HSPCs. Together these data reveal that NF-E2 is an important driver of human hematopoietic stem cell maintenance and T lineage differentiation.