WorldWideScience

Sample records for achievable rate regions

  1. An Achievable Rate Region for the Gaussian Interference Channel

    OpenAIRE

    Shang, Xiaohu; Chen, Biao

    2006-01-01

    An achievable rate region for the Gaussian interference channel is derived using Sato's modified frequency division multiplexing idea and a special case of Han and Kobayashi's rate region (denoted by $\\Gmat^\\prime$). We show that the new inner bound includes $\\Gmat^\\prime$, Sason's rate region $\\Dmat$, as well as the achievable region via TDM/FDM, as its subsets. The advantage of this improved inner bound over $\\Gmat^\\prime$ arises due to its inherent ability to utilize the whole transmit pow...

  2. An Achievable Rate Region for the Gaussian Interference Channel

    OpenAIRE

    Shang, Xiaohu; Chen, Biao

    2006-01-01

    An achievable rate region for the Gaussian interference channel is derived using Sato's modified frequency division multiplexing idea and a special case of Han and Kobayashi's rate region (denoted by $\\Gmat^\\prime$). We show that the new inner bound includes $\\Gmat^\\prime$, Sason's rate region $\\Dmat$, as well as the achievable region via TDM/FDM, as its subsets. The advantage of this improved inner bound over $\\Gmat^\\prime$ arises due to its inherent ability to utilize the whole transmit pow...

  3. A New Achievable Rate Region for the Cognitive Radio Channel

    CERN Document Server

    Hodtani, Ghosheh Abed

    2010-01-01

    Considering a general input distribution, using Gel'fand-Pinsker full binning scheme and the Han- Kobayashi (HK) jointly decoding strategy, we obtain a new achievable rate region for the cognitive radio channel (CRC) and then derive a simplified description for the region, by a combination of Cover superposition coding, binning scheme and the HK decoding technique. Our rate region (i) has an interesting interpretation, i.e., any rate in the region, as expected, has generally three additional terms in comparison with the KH region for the interference channel (IC): one term due to the input correlation, the other term due to binning scheme and the third term due to the interference dependent on the inputs, (ii) is really a generalization of the HK region for the IC to the CRC by the use of binning scheme, and as a result of this generalization we see that different versions of our region for the CRC are reduced to different versions of the previous results for the IC, and (iii) is a generalized and improved ve...

  4. A General Achievable Rate Region for Multiple-Access Relay Channels and Some Certain Capacity Theorems

    CERN Document Server

    Osmani-Bojd, Mohammad; Hodtani, Ghosheh Abed

    2011-01-01

    In this paper, we obtain a general achievable rate region and some certain capacity theorems for multiple-access relay channel (MARC), using decode and forward (DAF) strategy at the relay, superposition coding at the transmitters. Our general rate region (i) generalizes the achievability part of Slepian-Wolf multiple-access capacity theorem to the MARC, (ii) extends the Cover-El Gamal best achievable rate for the relay channel with DAF strategy to the MARC, (iii) gives the Kramer-Wijengaarden rate region for the MARC, (iv) meets max-flow min-cut upper bound and leads to the capacity regions of some important classes of the MARC.

  5. An Achievable Rate Region for Three-Pair Interference Channels with Noise

    CERN Document Server

    Bandemer, Bernd

    2012-01-01

    An achievable rate region for certain noisy three-user-pair interference channels is proposed. The channel class under consideration generalizes the three-pair deterministic interference channel (3-DIC) in the same way as the Telatar-Tse noisy two-pair interference channel generalizes the El Gamal-Costa injective channel. Specifically, arbitrary noise is introduced that acts on the combined interference signal before it affects the desired signal. This class of channels includes the Gaussian case. The rate region includes the best-known inner bound on the 3-DIC capacity region, dominates treating interference as noise, and subsumes the Han-Kobayashi region for the two-pair case.

  6. An Achievable Rate Region for the Asynchronous Multiple Access Channel with Feedback

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    An achievable rate region for the asynchronous multiple access channel with feedback is established through the use of superposition coding, list decoding and time sharing. The calculation results demonstrate that lack of synchronization does not affect the achievable rate region when the code block length tends to infinity, and that if the length of the code word is finite, especially not sufficiently larger than a fixed maximal delay, the asynchronization will cause a loss of the rate region. The amount of such a loss with its explanation for the reason is given, and the difference between the losses for the asynchronous multiple access channel with and without feedback is also discussed in this paper.

  7. On Achievable Rate Regions of the Asymmetric AWGN Two-Way Relay Channel

    CERN Document Server

    Ong, Lawrence; Johnson, Sarah J

    2011-01-01

    This paper investigates the additive white Gaussian noise two-way relay channel, where two users exchange messages through a relay. Asymmetrical channels are considered where the users can transmit data at different rates and at different power levels. We modify and improve existing coding schemes to obtain three new achievable rate regions. Comparing four downlink-optimal coding schemes, we show that the scheme that gives the best sum-rate performance is (i) complete-decode-forward, when both users transmit at low signal-to-noise ratio (SNR); (ii) functional-decode-forward with nested lattice codes, when both users transmit at high SNR; (iii) functional-decode-forward with rate splitting and time-division multiplexing, when one user transmits at low SNR and another user at medium--high SNR.

  8. An Achievable Rate Region for Cognitive Radio Channel With Common Message

    CERN Document Server

    Monemizadeh, Mostafa; Hodtani, Ghosheh Abed

    2011-01-01

    The cognitive radio channel with common message (CRCC) is considered. In this channel, similar to the cognitive radio channel (CRC), we have a cognitive user which has full non-causal knowledge of the primary message, and like the interference channel with common message (ICC), the information sources at the two transmitters are statistically dependent and the senders need to transmit not only the private message but also certain common message to their corresponding receivers. By using a specific combination of superposition coding, binning scheme and simultaneous decoding, we propose a unified achievable rate region for the CRCC which subsumes the several existing results for the CRC, ICC, interference channel without common message (IC), strong interference channel and compound multiple access channel with common information (SICC and CMACC).

  9. Achievable Rate Regions for the Causal Cognitive Interference Channel With Delay

    CERN Document Server

    Mirmohseni, Mahtab; Aref, Mohammad Reza

    2010-01-01

    In this paper, we introduce the Causal Cognitive Interference Channel With Delay (CC-IFC-WD) in which the cognitive user transmission can depend on the L future received symbols as well as the past ones. Taking the effect of the link delays into account, CC-IFC-WD fills the gap between the genie-aided and causal cognitive radio channels. We study three special cases: 1)Classical CC-IFC (L=0), 2)CC-IFC without delay (L=1) and 3)CC-IFC with a block length delay (L=n). In each situation, we obtain an inner bound on the capacity region. Our coding schemes make use of cooperative strategy by generalized block Markov superposition coding, collaborative strategy by rate splitting, and Gel'fand-Pinsker coding in order to pre-cancel part of the interference. Moreover, instantaneous relaying and non-causal partial Decode-and-Forward are employed in the second and third cases, respectively. The derived achievable rate regions under special conditions, reduce to several previously known ones.

  10. Road blocks in achieving a 100% voluntary blood donation rate in the South Asian region

    Directory of Open Access Journals (Sweden)

    Woodfield Graeme

    2007-01-01

    Full Text Available Voluntary blood donation rates are not high in the South Asian region, except in a few countries. The reasons for this are outlined and the roadblocks for improvement of the situation noted. The need for increased planning, both regionally and nationally, is emphasized and some factors that inhibit voluntary blood donation are mentioned. There is a real need to move from a system of reliance on ′replacement′ donors to a fully nonremunerated voluntary blood donation system, and the examples and lessons from successful countries should be carefully studied.

  11. Multi-Cell Random Beamforming: Achievable Rate and Degrees of Freedom Region

    CERN Document Server

    Nguyen, Hieu Duy; Hui, Hon Tat

    2012-01-01

    Random beamforming (RBF) is a practically favorable transmission scheme for multiuser multi-antenna downlink systems since it requires only partial channel state information (CSI) at the transmitter. Under the conventional single-cell setup, RBF is known to achieve the optimal sum-capacity scaling law as the number of users goes to infinity, thanks to the multiuser diversity effect that eliminates the inter-user interference. In this paper, we extend the study on RBF to a more practical multi-cell downlink system subject to the additional inter-cell interference (ICI). First, we consider the case of finite user's signal-to-noise ratio (SNR). We derive a closed-form expression of the achievable sum rate with the multi-cell RBF, based upon which we show the asymptotic sum-rate scaling law as the number of users goes to infinity. Next, we consider the high-SNR regime and for a tractable analysis assume that the number of users in each cell scales in a certain order with the per-cell SNR. Under this setup, we cha...

  12. Achievable Rate Regions for Dirty Tape Channels and "Joint Writing on Dirty Paper and Dirty Tape"

    CERN Document Server

    Khosravi-Farsani, Reza; Aref, Mohammad Reza

    2010-01-01

    We consider the Gaussian Dirty Tape Channel (DTC) Y=X+S+Z, where S is an additive Gaussian interference known causally to the transmitter. The general expression [max]\\_top(P_U,f(.),X=f(U,S))I(U;Y) is presented for the capacity of this channel. For linear assignment to f(.), i.e. X=U-{\\beta}S, this expression leads to the compensation strategy proposed previously by Willems to obtain an achievable rate for the DTC. We show that linear assignment to f(.) is optimal, under the condition that there exists a real number {\\beta}^* such that the pair (X+{\\beta}^* S,U) is independent of interference S. Furthermore, by applying a time-sharing technique to the achievable rate derived by linear assignment to f(.), an improved lower bound on the capacity of DTC is obtained. We also consider the Gaussian multiple access channel with additive interference, and study two different scenarios for this system. In the first case, both transmitters know interference causally while in the second, one transmitter has access to th...

  13. Crystallized Rate Regions for MIMO Transmission

    Directory of Open Access Journals (Sweden)

    Debbah Merouane

    2010-01-01

    Full Text Available When considering the multiuser SISO interference channel, the allowable rate region is not convex and the maximization of the aggregated rate of all the users by the means of transmission power control becomes inefficient. Hence, a concept of the crystallized rate regions has been proposed, where the time-sharing approach is considered to maximize the sumrate.In this paper, we extend the concept of crystallized rate regions from the simple SISO interference channel case to the MIMO/OFDM interference channel. As a first step, we extend the time-sharing convex hull from the SISO to the MIMO channel case. We provide a non-cooperative game-theoretical approach to study the achievable rate regions, and consider the Vickrey-Clarke-Groves (VCG mechanism design with a novel cost function. Within this analysis, we also investigate the case of OFDM channels, which can be treated as the special case of MIMO channels when the channel transfer matrices are diagonal. In the second step, we adopt the concept of correlated equilibrium into the case of two-user MIMO/OFDM, and we introduce a regret-matching learning algorithm for the system to converge to the equilibrium state. Moreover, we formulate the linear programming problem to find the aggregated rate of all users and solve it using the Simplex method. Finally, numerical results are provided to confirm our theoretical claims and show the improvement provided by this approach.

  14. Achievable rates for transmission of discrete constellations over the Gaussian MAC channe

    CERN Document Server

    Ghaffar, Rizwan; Lee, Jungwon

    2011-01-01

    In this paper we consider the achievable rate region of the Gaussian Multiple Access Channel (MAC) when suboptimal transmission schemes are employed. Focusing on the two-user MAC and assuming uncoded Pulse Amplitude Modulation (PAM), we derive a rate region that is a pentagon, and propose a strategy with which it can be achieved. We also compare the region with outer bounds and with orthogonal transmission.

  15. An Achievable Rate for the MIMO Individual Channel

    CERN Document Server

    Lomnitz, Yuval

    2010-01-01

    We consider the problem of communicating over a multiple-input multiple-output (MIMO) real valued channel for which no mathematical model is specified, and achievable rates are given as a function of the channel input and output sequences known a-posteriori. This paper extends previous results regarding individual channels by presenting a rate function for the MIMO individual channel, and showing its achievability in a fixed transmission rate communication scenario.

  16. Finite Block-Length Achievable Rates for Queuing Timing Channels

    OpenAIRE

    2011-01-01

    The exponential server timing channel is known to be the simplest, and in some sense canonical, queuing timing channel. The capacity of this infinite-memory channel is known. Here, we discuss practical finite-length restrictions on the codewords and attempt to understand the amount of maximal rate that can be achieved for a target error probability. By using Markov chain analysis, we prove a lower bound on the maximal channel coding rate achievable at blocklength $n$ and error probability $...

  17. Achievable Rates and Scaling Laws for Cognitive Radio Channels

    Directory of Open Access Journals (Sweden)

    Natasha Devroye

    2008-01-01

    Full Text Available Cognitive radios have the potential to vastly improve communication over wireless channels. We outline recent information theoretic results on the limits of primary and cognitive user communication in single and multiple cognitive user scenarios. We first examine the achievable rate and capacity regions of single user cognitive channels. Results indicate that at medium SNR (0–20 dB, the use of cognition improves rates significantly compared to the currently suggested spectral gap-filling methods of secondary spectrum access. We then study another information theoretic measure, the multiplexing gain. This measure captures the number of point-to-point Gaussian channels contained in a cognitive channel as the SNR tends to infinity. Next, we consider a cognitive network with a single primary user and multiple cognitive users. We show that with single-hop transmission, the sum capacity of the cognitive users scales linearly with the number of users. We further introduce and analyze the primary exclusive radius, inside of which primary receivers are guaranteed a desired outage performance. These results provide guidelines when designing a network with secondary spectrum users.

  18. Achievable Rates and Scaling Laws for Cognitive Radio Channels

    Directory of Open Access Journals (Sweden)

    Devroye Natasha

    2008-01-01

    Full Text Available Abstract Cognitive radios have the potential to vastly improve communication over wireless channels. We outline recent information theoretic results on the limits of primary and cognitive user communication in single and multiple cognitive user scenarios. We first examine the achievable rate and capacity regions of single user cognitive channels. Results indicate that at medium SNR (0–20 dB, the use of cognition improves rates significantly compared to the currently suggested spectral gap-filling methods of secondary spectrum access. We then study another information theoretic measure, the multiplexing gain. This measure captures the number of point-to-point Gaussian channels contained in a cognitive channel as the SNR tends to infinity. Next, we consider a cognitive network with a single primary user and multiple cognitive users. We show that with single-hop transmission, the sum capacity of the cognitive users scales linearly with the number of users. We further introduce and analyze the primary exclusive radius, inside of which primary receivers are guaranteed a desired outage performance. These results provide guidelines when designing a network with secondary spectrum users.

  19. Cesarean section rates in Italian regions: 1998-2002

    Directory of Open Access Journals (Sweden)

    Maria Pia Fantini

    2005-06-01

    Full Text Available

    Cesarean section (c-section rates have been increasing in many countries, and too frequently this rise does not seem to be justified by clinical grounds. To reduce c-section rates and achieve a proportion of 20% is among the goals of the Italian National Health Plan.

    In the following paper we provide an update on the distribution of rates amongst Italian regions and describe the association between regional hospital volumes and c-section rates. The national c-section rate increased from 31% in 1998 to 36% in 2002.

    The rates varied among regions and ranged from 20% in the Province of Bolzano to 56% in Campania. A significant association was observed between the regional hospital volumes for deliveries and c-section rates, regions with low hospital volumes performed more c-sections than high volume regions.

  20. Methods of achieving and maintaining an appropriate caesarean section rate.

    LENUS (Irish Health Repository)

    Robson, Michael

    2013-04-01

    Caesarean section rates continue to increase worldwide. The appropriate caesarean section rate remains a topic of debate among women and professionals. Evidence-based medicine has not provided an answer and depends on interpretation of the literature. Overall caesarean section rates are unhelpful, and caesarean section rates should not be judged in isolation from other outcomes and epidemiological characteristics. Better understanding of caesarean section rates, their consequences and their benefits will improve care, and enable learning between delivery units nationally and internationally. To achieve and maintain an appropriate caesarean section rate requires a Multidisciplinary Quality Assurance Programme in each delivery unit, recognising caesarean section rates as one of many factors that determine quality. Women will always choose the type of delivery that seems safest to them and their babies. Professionals need to monitor the quality of their practice continuously in a standardised way to ensure that women can make the right choice.

  1. Target weight achievement and ultrafiltration rate thresholds: potential patient implications.

    Science.gov (United States)

    Flythe, Jennifer E; Assimon, Magdalene M; Overman, Robert A

    2017-06-02

    Higher ultrafiltration (UF) rates and extracellular hypo- and hypervolemia are associated with adverse outcomes among maintenance hemodialysis patients. The Centers for Medicare and Medicaid Services recently considered UF rate and target weight achievement measures for ESRD Quality Incentive Program inclusion. The dual measures were intended to promote balance between too aggressive and too conservative fluid removal. The National Quality Forum endorsed the UF rate measure but not the target weight measure. We examined the proposed target weight measure and quantified weight gains if UF rate thresholds were applied without treatment time (TT) extension or interdialytic weight gain (IDWG) reduction. Data were taken from the 2012 database of a large dialysis organization. Analyses considered 152,196 United States hemodialysis patients. We described monthly patient and dialysis facility target weight achievement patterns and examined differences in patient characteristics across target weight achievement status and differences in facilities across target weight measure scores. We computed the cumulative, theoretical 1-month fluid-related weight gain that would occur if UF rates were capped at 13 mL/h/kg without concurrent TT extension or IDWG reduction. Target weight achievement patterns were stable over the year. Patients who did not achieve target weight (post-dialysis weight ≥ 1 kg above or below target weight) tended to be younger, black and dialyze via catheter, and had shorter dialysis vintage, greater body weight, higher UF rate and more missed treatments compared with patients who achieved target weight. Facilities had, on average, 27.1 ± 9.7% of patients with average post-dialysis weight ≥ 1 kg above or below the prescribed target weight. In adjusted analyses, facilities located in the midwest and south and facilities with higher proportions of black and Hispanic patients and higher proportions of patients with shorter TTs were more likely to

  2. School Performance Indicators, Accountability Ratings, and Student Achievement

    Science.gov (United States)

    Jackson, Shirley A.; Lunenburg, Fred C.

    2010-01-01

    Researchers have been challenged to find school-level characteristics that make a difference in student achievement. This study focused on a diverse sample of 24 middle schools to examine differences between schools rated Exemplary, Recognized, Academically Acceptable, and Academically Unacceptable on four performance indicator dimensions:…

  3. Achievable Rates for Two-Way Wire-Tap Channels

    CERN Document Server

    Tekin, Ender

    2007-01-01

    We consider two-way wire-tap channels, where two users are communicating with each other in the presence of an eavesdropper, who has access to the communications through a multiple-access channel. We find achievable rates for two different scenarios, the Gaussian two-way wire-tap channel, (GTW-WT), and the binary additive two-way wire-tap channel, (BATW-WT). It is shown that the two-way channels inherently provide a unique advantage for wire-tapped scenarios, as the users know their own transmitted signals and in effect help encrypt the other user's messages, similar to a one-time pad. We compare the achievable rates to that of the Gaussian multiple-access wire-tap channel (GMAC-WT) to illustrate this advantage.

  4. Improved Rate-Equivocation Regions for Secure Cooperative Communication

    CERN Document Server

    Marina, Ninoslav; Poor, H Vincent

    2011-01-01

    A simple four node network in which cooperation improves the information-theoretic secrecy is studied. The channel consists of two senders, a receiver, and an eavesdropper. One or both senders transmit confidential messages to the receiver, while the eavesdropper tries to decode the transmitted message. The main result is the derivation of a newly achievable rate-equivocation region that is shown to be larger than a rate-equivocation region derived by Lai and El Gamal for the relay-eavesdropper channel. When the rate of the helping interferer is zero, the new rate-equivocation region reduces to the capacity-equivocation region over the wire-tap channel, hence, the new achievability scheme can be seen as a generalization of a coding scheme proposed by Csiszar and Korner. This result can naturally be combined with a rate-equivocation region given by Tang et al. (for the interference assisted secret communication), yielding an even larger achievable rate-equivocation region.

  5. Distributed MIMO receiver - Achievable rates and upper bounds

    CERN Document Server

    Sanderovich, Amichai; Steinberg, Yossef

    2007-01-01

    In this paper we investigate the achievable rate of a system that includes a nomadic transmitter with several antennas, which is received by multiple agents, exhibiting independent channel gains and additive circular-symmetric complex Gaussian noise. In the nomadic regime, we assume that the agents do not have any decoding ability. These agents process their channel observations and forward them to the final destination through lossless links with a fixed capacity. We propose new achievable rates based on elementary compression and also on a Wyner-Ziv (CEO-like) processing, for both fast fading and block fading channels, as well as for general discrete channels. The simpler two agents scheme is solved, up to an implicit equation with a single variable. Limiting the nomadic transmitter to a circular-symmetric complex Gaussian signalling, new upper bounds are derived for both fast and block fading, based on the vector version of the entropy power inequality. These bounds are then compared to the achievable rate...

  6. Production rates of major regional Floras

    NARCIS (Netherlands)

    Polhill, R.M.

    1989-01-01

    The ambitious programme of major regional Floras for developing countries initiated in the late 1940’s to 1960’s is now mostly under serious reappraisal because of the slow rates of progress, coupled with political changes, financial restrictions and evolving technology. From our present viewpoint i

  7. Regional sulfur dioxide emissions: shall we achieve the goal?

    Science.gov (United States)

    Tan, X.; Shi, L.; Wang, M.; Wang, JY

    2017-01-01

    Although economic growth is slowing down in the new normal period, air pollution is still a very serious problem in China. The 15% binding goal of sulfur dioxide emission reduction from 2016 to 2020, as stipulated in the 13th Five-Year Plan, has been an ambitious target for the Chinese government. This paper studies the synthetic evaluation and forecasting analysis of sulfur dioxide in China by means of a “grey model” approach combined with the grey relational analysis methods, with the panel data of 31 provinces from 2005 to 2015. Grey analysis used to analyse a system with imperfect information, such that a variety of available solutions is reviewed, and the optimal solution is identified. Some encouraging results show that national emissions and a majority of provinces will achieve the target. Over time, the gap of regional differences is rapidly closing. According to the results of grey relational analysis, we find industrial structure and energy consumption have a more significant impact on sulfur dioxide emissions than GDP. Atmospheric treatment investment and environmental protection manpower play a more important role in emissions variation. Based on the findings, we should distinguish different factors and take different measures to protect the environment.

  8. Achieving the Gaussian Rate-Distortion Function by Prediction

    CERN Document Server

    Zamir, Ram; Erez, Uri

    2007-01-01

    The "water-filling" solution for the quadratic rate-distortion function of a stationary Gaussian source is given in terms of its power spectrum. This formula naturally lends itself to a frequency domain "test-channel" realization. We provide an alternative time-domain realization for the rate-distortion function, based on linear prediction. This solution has some interesting implications, including the optimality at all distortion levels of pre/post filtered vector-quantized differential pulse code modulation (DPCM), and a duality relationship with decision-feedback equalization (DFE) for inter-symbol interference (ISI) channels.

  9. Achievable Rate of Spectrum Sharing Cognitive Radio Multiple-Antenna Channels

    KAUST Repository

    Sboui, Lokman

    2015-04-28

    We investigate the spectral efficiency gain of an uplink Cognitive Radio (CR) Multi-Input-Multi-Output system in which the Secondary User (SU) is allowed to share the spectrum with the Primary User (PU) using a specific precoding scheme to communicate with a common receiver. The proposed scheme exploits, at the same time, the free eigenmodes of the primary channel after a space alignment procedure and the interference threshold tolerated by the PU. At the common receiver, we adopt a Successive Interference Cancellation (SIC) technique to eliminate the effect of the detected primary signal transmitted through the exploited eigenmodes. Furthermore, we analyze the SIC operation inaccuracy as well as the CSI estimation imperfection on the PU and SU throughputs. Numerical results show that our proposed scheme enhances considerably the cognitive achievable rate. For instance, in case of a perfect detection of the PU signal, the CR rate remains non-zero for high Signal to Noise Ratio which is usually impossible when we only employ a space alignment technique. We show that a modified water-filling power allocation policy at the PU can increase the secondary rate with a marginal degradation of the primary rate. Finally, we investigate the behavior of the PU and SU rates through the study of the rate achievable region.

  10. THE ROLE OF REGIONAL TRADE AGREEMENTS IN ACHIEVING FOOD SECURITY

    Directory of Open Access Journals (Sweden)

    Agnieszka Sapa

    2016-06-01

    Full Text Available The aim of the article was to identify certain relationships between international trade and food security with special emphasis on regional trade agreements. The study was conducted on the basis of domestic and foreign sources of literature. Unresolved problem of food insecurity indicate not only identification of the source of this state , but also ways to improve the food situation in the world. One of the factors that improve directly and indirectly food security level is international trade. Limited capability for performing trade liberalization at the global level means that the way of improving access to food is regionalism. However, taking full advantage of regional trade agreements to solve the problem of food insecurity must be accompanied by elimination or reduction the non-tariff barriers, that still exist.

  11. On the Achievable Throughput Region of Multiple-Access Fading Channels with QoS Constraints

    CERN Document Server

    Qiao, Deli; Velipasalar, Senem

    2009-01-01

    Effective capacity, which provides the maximum constant arrival rate that a given service process can support while satisfying statistical delay constraints, is analyzed in a multiuser scenario. In particular, we study the achievable effective capacity region of the users in multiaccess fading channels (MAC) in the presence of quality of service (QoS) constraints. We assume that channel side information (CSI) is available at both the transmitters and the receiver, and superposition coding technique with successive decoding is used. When the power is fixed at the transmitters, we show that varying the decoding order with respect to the channel state can significantly increase the achievable throughput region. For a two-user case, we obtain the optimal decoding strategy when the users have the same QoS constraints. Meanwhile, it is shown that time-division multiple-access (TDMA) can achieve better performance than superposition coding with fixed successive decoding order at the receiver side for certain QoS con...

  12. Rate-adaptive Constellation Shaping for Near-capacity Achieving Turbo Coded BICM

    DEFF Research Database (Denmark)

    Yankov, Metodi Plamenov; Forchhammer, Søren; Larsen, Knud J.;

    2014-01-01

    In this paper the problem of constellation shaping is considered. Mapping functions are designed for a many- to-one signal shaping strategy, combined with a turbo coded Bit-interleaved Coded Modulation (BICM), based on symmetric Huffman codes with binary reflected Gray-like properties. An algorithm...... is derived for finding the Huffman code with such properties for a variety of alphabet sizes, and near-capacity performance is achieved for a wide SNR region by dynamically choosing the optimal code rate, constellation size and mapping function based on the operating SNR point and assuming perfect channel...... quality estimation. Gains of more than 1dB are observed for high SNR compared to conventional turbo coded BICM, and it is shown that the mapping functions designed here significantly outperform current state of the art Turbo- Trellis Coded Modulation and other existing constellation shaping methods...

  13. Achievable Rates and Outer Bound for the Half-Duplex MAC with Generalized Feedback

    CERN Document Server

    Haija, Ahmad Abu Al

    2011-01-01

    This paper provides comprehensive coding and outer bound for the half-duplex multiple access channel with generalized feedback (MAC-GF). Two users communicate with one destination over a discrete memoryless channel using time division. Each transmission block is divided into 3 time slots with variable durations: the destination is always in receive mode, while each user alternatively transmits and receives during the first 2 time slots, then both cooperate to send information during the last one. The paper proposes two decode-forward based coding schemes, analyzes their rate regions, and also derives two outer bounds with rate constraints similar to the achievable regions. Both schemes requires no block Makovity, allowing the destination to decode at the end of each block without any delay. In the first scheme, the codewords in the third time slot are superimposed on the codewords of the first two, whereas in the second scheme, these codewords are independent. While the second scheme is simpler, the first sch...

  14. Differences in achieving treatment goals with statin use in various regions of Poland – 3ST-POL study results

    Directory of Open Access Journals (Sweden)

    Daniel Śliż

    2015-12-01

    Full Text Available [b][/b][b]Introduction and objective.[/b] Dyslipidemia is the most common factor leading to ischemic heart disease, which is one of the leading causes of death. The use of statins is the most important preventative measure of ischemic heart disease; however, their efficacy in patients in Poland is still too low. The purpose of this study was to evaluate regional differences in achieving treatment goals in total cholesterol (TC and LDL cholesterol levels in patients treated with statins on an outpatient basis. [b]Materials and methods.[/b] A survey was used to evaluate efficacy of treatment, completed by 49,950 patients in Poland treated with statins in 2008. The territory of Poland was divided into 4 research regions: the Northeast (NE, Northwest (NW, Southeast (SE, and Southwest (SW regions. [b]Results.[/b] The largest group of patients resided in the SW region, the smallest in the SE region. Participants of the study suffered from hypercholesterolemia, on average, for at least a year before completing the study survey. Effective treatment leading to achievement of target TC was observed in less than 10% of the patients. Rate of achievement of target cholesterol levels was highest in the NE region, lowest in the NW region. Cardiologists were more successful in achieving therapeutic goals than GPs. Similar correlations between regions and doctors’ specializations were observed for LDL values. [b]Conclusions.[/b] Significant differences in the efficacy of treatment with statins were observed among the study group and were evaluated based on achievement of target TC and LDL cholesterol levels. Better results achieved in the NE region may be because the region includes the Masovian province, which is the most economically developed region in Poland.

  15. Crystallized Rates Region of the Interference Channel via Correlated Equilibrium with Interference as Noise

    CERN Document Server

    Charafeddine, Mohamad; Paulraj, Arogyaswami; Cioffi, John

    2010-01-01

    Treating the interference as noise in the n-user interference channel, the paper describes a novel approach to the rates region, composed by the time-sharing convex hull of 2^n-1 corner points achieved through On/Off binary power control. The resulting rates region is denoted crystallized rates region. By treating the interference as noise, the n-user rates region frontiers has been found in the literature to be the convex hull of n hyper-surfaces. The rates region bounded by these hyper-surfaces is not necessarily convex, and thereby a convex hull operation is imposed through the strategy of time-sharing. This paper simplifies this rates region in the n-dimensional space by having only an On/Off binary power control. This consequently leads to 2^n-1 corner points situated within the rates region. A time-sharing convex hull is imposed onto those corner points, forming the crystallized rates region. The paper focuses on game theoretic concepts to achieve that crystallized convex hull via correlated equilibrium...

  16. Achievable rate of spectrum sharing cognitive radio systems over fading channels at low-power regime

    KAUST Repository

    Sboui, Lokman

    2014-11-01

    We study the achievable rate of cognitive radio (CR) spectrum sharing systems at the low-power regime for general fading channels and then for Nakagami fading. We formally define the low-power regime and present the corresponding closed-form expressions of the achievable rate lower bound under various types of interference and/or power constraints, depending on the available channel state information of the cross link (CL) between the secondary-user transmitter and the primary-user receiver. We explicitly characterize two regimes where either the interference constraint or the power constraint dictates the optimal power profile. Our framework also highlights the effects of different fading parameters on the secondary link (SL) ergodic achievable rate. We also study more realistic scenarios when there is either 1-bit quantized channel feedback from the CL alone or 2-bit feedback from both the CL and the SL and propose simple power control schemes and show that these schemes achieve the previously achieved rate at the low-power regime. Interestingly, we show that the low-power regime analysis provides a specific insight into the maximum achievable rate behavior of CR that has not been reported by previous studies.

  17. Improvement of the Han-Kobayashi Rate Region for General Interference Channel-v2

    CERN Document Server

    Hodtani, Ghosheh Abed

    2010-01-01

    Allowing the input auxiliary random variables to be correlated and using the binning scheme, the Han-Kobayashi (HK) rate region for general interference channel is partially improved. The obtained partially new achievable rate region (i) is compared to the HK region and its simplified description, i.e., Chong-Motani-Garg (CMG) region, in a detailed and favorable manner, by considering different versions of the regions, and (ii) has an interesting and easy interpretation: as expected, any rate in our region has generally two additional terms in comparison with the HK region (one due to the input correlation and the other as a result of the binning scheme). Keywords. Interference channel, Input correlation, Binning scheme

  18. Technology Enhanced Learning Environments for Closing the Gap in Student Achievement between Regions: Does It Work?

    Science.gov (United States)

    Cakir, Hasan; Delialioglu, Omer; Dennis, Alan; Duffy, Thomas

    2009-01-01

    Student achievement gap between urban and suburban regions are a major issue in U.S. schools. Technology enhanced learning environments that support teaching and learning process with advanced technology may close this achievement gap. This paper examines the impact of student and school factors with an emphasis on schools' geographic location on…

  19. A New Achievable Rate and the Capacity of Some Classes of Multilevel Relay Network

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Aref

    2008-04-01

    Full Text Available A new achievable rate based on a partial decoding scheme is proposed for the multilevel relay network. A novel application of regular encoding and backward decoding is presented to implement the proposed rate. In our scheme, the relays are arranged in feed-forward structure from the source to the destination. Each relay in the network decodes only part of the transmitted message by the previous relay. The proposed scheme differs from general parity forwarding scheme in which each relay selects some relays in the network but decodes all messages of the selected relays. It is also shown that in some cases higher rates can be achieved by the proposed scheme than previously known by Xie and Kumar. For the classes of semideterministic and orthogonal relay networks, the proposed achievable rate is shown to be the exact capacity. The application of the defined networks is very well understood in wireless networking scenarios.

  20. Analyzing Turkey's data from TIMSS 2007 to investigate regional disparities in eighth grade science achievement

    Science.gov (United States)

    Erberber, Ebru

    Turkey is expected to be a full member of the European Union (EU) by 2013. In the course of its integration into the EU, Turkey has been simultaneously facing access, quality, and equity issues in education. Over the past decade, substantial progress has been made on increasing the access. However, improving the country's low level of education quality and achieving equity in quality education across the regions continue to be a monumental challenge in Turkey. Most recently, results from the Trends in International Mathematics and Science Study (TIMSS) 2007 indicated that Turkey's educational achievement at the eighth grade, the end of compulsory primary education in Turkey, was far below that of other countries in the EU. Considering Turkey's long standing socioeconomic disparities between the western and eastern parts of the country, the challenges of improving overall education quality are coupled with the challenges of achieving equity in learning outcomes for students across the regions. This dissertation used data from TIMSS 2007 to document the extent of Turkey's regional differences in science achievement at the eighth grade and to investigate factors associated with these differences. Findings from a series of analyses using hierarchical linear models suggested that attempts to increase Turkish students' achievement and close the achievement gaps between regions should target the students in the undeveloped regions, particularly in Southeastern Anatolia and Eastern Anatolia. Designing interventions to improve competency in Turkish and to compensate for the shortcomings of insufficient parental education, limited home educational resources, poor school climate for academic achievement, and inadequate instructional equipment and facilities might be expected to close the regional achievement gaps as well as raise the overall achievement level in Turkey.

  1. A Qualitative Study of High Student Achievement in a Rural Appalachian Region: Perceptions of Selected Superintendents

    Science.gov (United States)

    Mathis, Regina

    2011-01-01

    This qualitative study was based on grounded theory and used purposive sampling for selecting participants. The sample for this study included 12 of the 16 superintendents in this region. This rural Appalachian region has historically outperformed the remainder of the southeastern state on reading and math achievement tests at the elementary and…

  2. Project REACH. Regional Education to Achieve with Company Help. Performance Report.

    Science.gov (United States)

    Parkway School District, Chesterfield, MO.

    Project REACH (Regional Education to Achieve with Company) was a regional workplace literacy (WL) program designed to increase the levels of literacy, job performance/satisfaction/retention, productivity, and self-esteem of the work force of six businesses in the Saint Louis area and to foster the development of business-education partnerships for…

  3. Achievable Outage Rates In Cognitive Radio Networks under Imperfect Spectrum Sensing

    Directory of Open Access Journals (Sweden)

    N. Tafaghodi Khajavi

    2012-06-01

    Full Text Available In this paper, we aim at deriving the outage rates achieved by the primary user due spectrum sensing in a cognitive radio network, that we call sensing-induced primary outage rates. To reach this goal, in the first step, instead of classical spectrum sensing techniques that evaluate sensing performance only based on correct detection of the presence of the primary user’s signal, we propose a modified framework that also takes into account the correct detection of the absence of primary user’s signal for spectrum sensing performance evaluation. In a second step, we derive the information rates achieved by the coexistence of a primary and a cognitive network. In the last step, assuming slow fading sensing channels, we derive the sensing-induced primary outage rates, i.e., outage rates achieved by the primary network in the presence of a CR with imperfect spectrum sensing, characterized by a given miss-detection probability. Numerical results show that the proposed spectrum sensing outperforms conventional spectrum sensing techniques in terms of primary signal outage rates and total achievable throughputs, without any increase in the cognitive radio complexity.

  4. Relationship between regional spending on vascular care and amputation rate

    Science.gov (United States)

    Goodney, Philip P.; Travis, Lori L.; Brooke, Benjamin S.; DeMartino, Randall R.; Goodman, David C.; Fisher, Elliott S.; Birkmeyer, John D.

    2014-01-01

    Importance While lower extremity revascularization is effective in preventing amputation, the relationship between spending on vascular care and regional amputation rates remains unclear. Objective To test the hypothesis that higher regional spending on vascular care is associated with lower amputation rates in patients with severe peripheral arterial disease (PAD). Design Retrospective cohort study. Setting United States Medicare patients, 2003-2010 Participants 18,463 patients who underwent major PAD-related amputation. Exposures Price-adjusted Medicare spending on revascularization procedures and related vascular care in the year before lower extremity amputation, across hospital referral regions. Main Outcome Measure(s) Correlation coefficient between regional spending on vascular care and regional rates of PAD-related amputation. Results Among patients ultimately subject to amputation, 64% were admitted to the hospital in the year prior to amputation for revascularization, wound-related care, or both; 36% were admitted only for their amputation. The mean cost of inpatient care in the year before amputation, including the amputation itself, was $22,405, but varied from $11,077 (Bismarck, North Dakota) to $42,613 (Salinas, California) (pamputation rates (R=0.10, p=0.06). Regions most aggressive in the use of endovascular interventions which most likely to have high spending (R=0.42, p=0.002) and high amputation rates (R=0.40, p=0.004). Conclusions Regions that spend the most on vascular care is highest perform the most procedures, especially endovascular interventions, in the year before amputation. However, there is little evidence that higher regional spending is associated with lower amputation rates. This suggests an opportunity to limit costs in vascular care without compromising quality. PMID:24258010

  5. Regional variation in rates of pediatric perforated appendicitis.

    Science.gov (United States)

    Sarda, Samir; Short, Heather L; Hockenberry, Jason M; McCarthy, Ian; Raval, Mehul V

    2017-09-01

    While trends in perforated appendicitis (PA) rates have been studied, regional variability in pediatric admissions for PA remains unknown. A retrospective, cross-sectional analysis of the 2006-2012 Kids' Inpatient Database was conducted to examine variation in PA admission rates by region of the United States and insurance status. PA rates were calculated and reported as per 1000 admissions in accordance with national quality measure specifications. National PA rates per 1000 admissions for 2006, 2009, and 2012 were 313.9, 279.2, and 309.1, respectively. Similarly, all regions demonstrated a statistically significant decrease in PA rates between 2006 and 2009 (p<0.001), where the increase in rates between 2009 and 2012 was only statistically significant in the Midwest [Odds Ratio (OR) 1.07; 95% Confidence Interval (95%CI) 1.03-1.12] and West (OR 1.10; 95% CI 1.07-1.14). The Northeast consistently experienced the lowest PA rates. The odds of PA were highest among uninsured patients (OR 1.35; 95% CI 1.31-1.29). The South had the highest proportion of uninsured children, and these patients had the highest odds of perforation (OR 1.57; 95% CI 1.21-2.02). For children with appendicitis, geographic region and insurance status appear to be associated with perforation upon presentation. Understanding regional variation in pediatric PA rates may inform health policymakers in the constantly evolving insurance coverage landscape. Level III Treatment Study - Retrospective comparative study of appendicitis presentation in children by region of the country. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Cognitive, Parent and Teacher Rating Measures of Executive Functioning: Shared and Unique Influences on School Achievement.

    Science.gov (United States)

    Dekker, Marielle C; Ziermans, Tim B; Spruijt, Andrea M; Swaab, Hanna

    2017-01-01

    Very little is known about the relative influence of cognitive performance-based executive functioning (EF) measures and behavioral EF ratings in explaining differences in children's school achievement. This study examined the shared and unique influence of these different EF measures on math and spelling outcome for a sample of 84 first and second graders. Parents and teachers completed the Behavior Rating Inventory of Executive Function (BRIEF), and children were tested with computer-based performance tests from the Amsterdam Neuropsychological Tasks (ANT). Mixed-model hierarchical regression analyses, including intelligence level and age, showed that cognitive performance and teacher's ratings of working memory and shifting concurrently explained differences in spelling. However, teacher's behavioral EF ratings did not explain any additional variance in math outcome above cognitive EF performance. Parent's behavioral EF ratings did not add any unique information for either outcome measure. This study provides support for the ecological validity of performance- and teacher rating-based EF measures, and shows that both measures could have a complementary role in identifying EF processes underlying spelling achievement problems. The early identification of strengths and weaknesses of a child's working memory and shifting capabilities, might help teachers to broaden their range of remedial intervention options to optimize school achievement.

  7. Cognitive, Parent and Teacher Rating Measures of Executive Functioning: Shared and Unique Influences on School Achievement

    Science.gov (United States)

    Dekker, Marielle C.; Ziermans, Tim B.; Spruijt, Andrea M.; Swaab, Hanna

    2017-01-01

    Very little is known about the relative influence of cognitive performance-based executive functioning (EF) measures and behavioral EF ratings in explaining differences in children's school achievement. This study examined the shared and unique influence of these different EF measures on math and spelling outcome for a sample of 84 first and second graders. Parents and teachers completed the Behavior Rating Inventory of Executive Function (BRIEF), and children were tested with computer-based performance tests from the Amsterdam Neuropsychological Tasks (ANT). Mixed-model hierarchical regression analyses, including intelligence level and age, showed that cognitive performance and teacher's ratings of working memory and shifting concurrently explained differences in spelling. However, teacher's behavioral EF ratings did not explain any additional variance in math outcome above cognitive EF performance. Parent's behavioral EF ratings did not add any unique information for either outcome measure. This study provides support for the ecological validity of performance- and teacher rating-based EF measures, and shows that both measures could have a complementary role in identifying EF processes underlying spelling achievement problems. The early identification of strengths and weaknesses of a child's working memory and shifting capabilities, might help teachers to broaden their range of remedial intervention options to optimize school achievement. PMID:28194121

  8. Regional intensity of vascular care and lower extremity amputation rates

    Science.gov (United States)

    Goodney, Philip P.; Holman, Kerianne; Henke, Peter K.; Travis, Lori L.; Dimick, Justin B.; Stukel, Therese A.; Fisher, Elliott. S.; Birkmeyer, John D.

    2013-01-01

    Objective To examine the relationship between the intensity of vascular care and population-based rate of major lower extremity amputation (above-or below-knee) from vascular disease. Background Because patient-level differences do not fully explain the variation in amputation rate across the United States, we hypothesized that variation in intensity of vascular care may also affect regional rates of amputation. Methods Intensity of vascular care was defined as the proportion of Medicare patients who underwent any vascular procedure in the year prior to amputation, calculated at the regional level (2003–2006), using the 306 hospital referral regions in the Dartmouth Atlas of Healthcare. We examined relationship between intensity of vascular care and major amputation rate, at the regional level, between 2007–2009. Results Amputation rates varied widely by region, from 1 to 27 per 10,000 Medicare patients. Compared to regions in the lowest quintile of amputation rate, patients in the highest quintile were commonly African American (50% versus 13%) and diabetic (38% versus 31%). Intensity of vascular care also varied across regions: fewer than 35% of patients underwent revascularization in the lowest quintile of intensity, while nearly 60% of patients underwent revascularization in the highest quintile. Overall, there was an inverse correlation between intensity of vascular care and amputation rate ranging from R= −0.36 for outpatient diagnostic and therapeutic procedures, to R= −0.87 for inpatient surgical revascularizations. In analyses adjusting for patient characteristics and socioeconomic status, patients in high vascular care regions were significantly less likely to undergo amputation without an antecedent attempt at revascularization (OR 0.37, 95% CI 0.34–0.37, pamputation varies, and regions with the most intensive vascular care have the lowest amputation rate, although the observational nature of associations do not impart causality. High

  9. Prekindergarten Children's Executive Functioning Skills and Achievement Gains: The Utility of Direct Assessments and Teacher Ratings

    Science.gov (United States)

    Fuhs, Mary Wagner; Farran, Dale Clark; Nesbitt, Kimberly Turner

    2015-01-01

    An accumulating body of evidence suggests that young children who exhibit greater executive functioning (EF) skills in early childhood also achieve more academically. The goal of the present study was to examine the unique contributions of direct assessments and teacher ratings of children's EF skills at the beginning of prekindergarten (pre-k) to…

  10. Educational Seduction: The Effect of Instructor Expressiveness and Lecture Content on Student Ratings and Achievement.

    Science.gov (United States)

    Perry, Raymond P.; And Others

    1979-01-01

    Previous "educational seduction" research suggested that teacher differences in expressiveness controlled the degree to which lecture content affected student ratings differently from student achievement. We attempted to replicate this Expressiveness x Content x Measures interaction in four simulated college classes. Student incentive and study…

  11. Achievable Rates for Four-Dimensional Coded Modulation with a Bit-Wise Receiver

    CERN Document Server

    Alvarado, Alex

    2013-01-01

    We study achievable rates for four-dimensional (4D) constellations for spectrally efficient optical systems based on a (suboptimal) bit-wise receiver. We show that PM-QPSK outperforms the best 4D constellation designed for uncoded transmission by approximately 1 dB. Numerical results using LDPC codes validate the analysis.

  12. Achieving Global Optimality for Weighted Sum-Rate Maximization in the K-User Gaussian Interference Channel with Multiple Antennas

    CERN Document Server

    Liu, Liang; Chua, Kee-Chaing

    2012-01-01

    Characterizing the global maximum of weighted sum-rate (WSR) for the K-user Gaussian interference channel (GIC), with the interference treated as Gaussian noise, is a key problem in wireless communication. However, due to the users' mutual interference, this problem is in general non-convex and thus cannot be solved directly by conventional convex optimization techniques. In this paper, by jointly utilizing the monotonic optimization and rate profile techniques, we develop a new framework to obtain the globally optimal power control and/or beamforming solutions to the WSR maximization problems for the GICs with single-antenna transmitters and single-antenna receivers (SISO), single-antenna transmitters and multi-antenna receivers (SIMO), or multi-antenna transmitters and single-antenna receivers (MISO). Different from prior work, this paper proposes to maximize the WSR in the achievable rate region of the GIC directly by exploiting the facts that the achievable rate region is a "normal" set and the users' WSR...

  13. Educational achievement of immigrant adolescents in Spain: do gender and region of origin matter?

    Science.gov (United States)

    Vaquera, Elizabeth; Kao, Grace

    2012-01-01

    This study explores the educational achievement of immigrant youth in Spain employing data from 3 waves of the Longitudinal Study of Families and Childhood (Pànel de Famílies i Infància), a representative sample of children in Catalonia first interviewed at ages 13-16 in 2006 (N = 2,710). Results suggest consistent disadvantage in achievement among first-generation students. Differences in achievement between the second and third generations are apparent in bivariate analyses, but are explained by observable characteristics in multivariate analyses. Gender-specific analyses uncover a large achievement gap between first-generation girls and their third-generation counterparts, but no equivalent gap for boys. Region-of-origin differences are modest, with the exception of Latin American adolescents who exhibit the lowest educational outcomes. The significance of perceptions about school on achievement are discussed.

  14. On achievable rates of interference and cognitive channels with a relay

    KAUST Repository

    Zorgui, Marwen

    2015-08-30

    We consider a two-user interference channel assisted by a relay. Treating interference as noise at the receivers, and adopting an amplify and forward (AF) strategy at the relay, we derive achievable rates of both users, for given powers. Next, we solve the optimal power allocation problem maximizing the weighted sum rate of both users with and without relay power optimization. In particular, we propose a simple iterative line search algorithm solving the joint optimization problem over the three transmit powers and show that optimizing the relay power enhances the performance of the system. Then, considering the first user as a primary user, we determine the maximum instantaneous rate that the secondary user can achieve subject to an outage constraint with respect to the primary user and a peak power constraint. We show that, likewise the first part, jointly optimizing the secondary user and the relay transmit powers enhances the secondary user performance.

  15. On the Achievable Rate of Stationary Rayleigh Flat-Fading Channels with Gaussian Inputs

    CERN Document Server

    Dörpinghaus, Meik

    2011-01-01

    In this work, we consider a discrete-time stationary Rayleigh flat-fading channel with unknown channel state information at transmitter and receiver. The law of the channel is presumed to be known to the receiver. In addition, we assume the power spectral density (PSD) of the fading process to be compactly supported. For i.i.d. zero-mean proper Gaussian input distributions, we investigate the achievable rate. One of the main contributions is the derivation of two new upper bounds on the achievable rate with zero-mean proper Gaussian input symbols. The first one holds only for the special case of a rectangular PSD and depends on the SNR and the spread of the PSD. Together with a lower bound on the achievable rate, which is achievable with i.i.d. zero-mean proper Gaussian input symbols, we have found a set of bounds which is tight in the sense that their difference is bounded. Furthermore, we show that the high SNR slope is characterized by a pre-log of 1-2f_d, where f_d is the normalized maximum Doppler freque...

  16. Maximizing Expected Achievable Rates for Block-Fading Buffer-Aided Relay Channels

    KAUST Repository

    Shaqfeh, Mohammad

    2016-05-25

    In this paper, the long-term average achievable rate over block-fading buffer-aided relay channels is maximized using a hybrid scheme that combines three essential transmission strategies, which are decode-and-forward, compress-and-forward, and direct transmission. The proposed hybrid scheme is dynamically adapted based on the channel state information. The integration and optimization of these three strategies provide a more generic and fundamental solution and give better achievable rates than the known schemes in the literature. Despite the large number of optimization variables, the proposed hybrid scheme can be optimized using simple closed-form formulas that are easy to apply in practical relay systems. This includes adjusting the transmission rate and compression when compress-and-forward is the selected strategy based on the channel conditions. Furthermore, in this paper, the hybrid scheme is applied to three different models of the Gaussian block-fading buffer-aided relay channels, depending on whether the relay is half or full duplex and whether the source and the relay have orthogonal or non-orthogonal channel access. Several numerical examples are provided to demonstrate the achievable rate results and compare them to the upper bounds of the ergodic capacity for each one of the three channel models under consideration.

  17. Achievable Rates of UAV-Relayed Cooperative Cognitive Radio MIMO Systems

    KAUST Repository

    Sboui, Lokman

    2017-04-19

    We study the achievable rate of an uplink MIMO cognitive radio system where the primary user (PU) and the secondary user (SU) aim to communicate to the closest primary base station (BS) via a multi-access channel through the same unmanned aerial vehicle (UAV) relay. The SU message is then forwarded from the primary BS to the secondary network with a certain incentive reward as a part of the cooperation protocol between both networks. A special linear precoding scheme is proposed to enable the SU to exploit the PU free eigenmodes. We analyze two scenarios in which the UAV relay gain matrix is either fixed or optimized. We derive the optimal power allocation that maximizes the achievable rate of the SU respecting power budget, interference, and relay power constraints. Numerical results highlight the cognitive rate gain of our proposed scheme with respect to various problem parameters. We also highlight the effect of UAV altitude on the SU and PU rates. Finally, when the relay matrix is optimized, we show that the PU rate is remarkably enhanced and that the SU rate is only improved at high power regime.

  18. University Knowledge Spillovers & Regional Start-up Rates

    DEFF Research Database (Denmark)

    Hellerstedt, Karin; Wennberg, Karl; Frederiksen, Lars

    2014-01-01

    This chapter investigates how regional start-up rates in the knowledge-intensive services and high-tech industries are influenced by knowledge spillovers from both universities and firm-based R&D activities. Integrating insights from economic geography and organizational ecology into the literatu...

  19. Achievable information rates estimates in optically amplified transmission systems using nonlinearity compensation and probabilistic shaping.

    Science.gov (United States)

    Semrau, Daniel; Xu, Tianhua; Shevchenko, Nikita A; Paskov, Milen; Alvarado, Alex; Killey, Robert I; Bayvel, Polina

    2017-01-01

    Achievable information rates (AIRs) of wideband optical communication systems using a ∼40  nm (∼5  THz) erbium-doped fiber amplifier and ∼100  nm (∼12.5  THz) distributed Raman amplification are estimated based on a first-order perturbation analysis. The AIRs of each individual channel have been evaluated for DP-64QAM, DP-256QAM, and DP-1024QAM modulation formats. The impact of full-field nonlinear compensation (FF-NLC) and probabilistically shaped constellations using a Maxwell-Boltzmann distribution were studied and compared to electronic dispersion compensation. It has been found that a probabilistically shaped DP-1024QAM constellation, combined with FF-NLC, yields achievable information rates of ∼75  Tbit/s for the EDFA scheme and ∼223  Tbit/s for the Raman amplification scheme over a 2000 km standard single-mode fiber transmission.

  20. Achievable Rate of Multi-relay Cognitive Radio MIMO Channel with Space Alignment

    KAUST Repository

    Sboui, Lokman

    2015-04-21

    We study the impact of multiple relays on the primary user (PU) and secondary user (SU) rates of underlay MIMO cognitive radio. Both users exploit amplify-and-forward relays to communicate with the destination. A space alignment technique and a special linear precoding and decoding scheme are applied to allow the SU to use the resulting free eigenmodes. In addition, the SU can communicate over the used eigenmodes under the condition of respecting an interference constraint tolerated by the PU. At the destination, a successive interference cancellation (SIC) is performed to estimate the secondary signal. We present the explicit expressions of the optimal PU and SU powers that maximize their achievable rates. In the numerical results, we show that our scheme provides cognitive rate gain even in absence of tolerated interference. In addition, we show that increasing the number of relays enhances the PU and SU rates at low power regime and/or when the relays power is sufficiently high.

  1. Achieving high bit rate logical stochastic resonance in a bistable system by adjusting parameters

    Science.gov (United States)

    Yang, Ding-Xin; Gu, Feng-Shou; Feng, Guo-Jin; Yang, Yong-Min; Ball, Andrew

    2015-11-01

    The phenomenon of logical stochastic resonance (LSR) in a nonlinear bistable system is demonstrated by numerical simulations and experiments. However, the bit rates of the logical signals are relatively low and not suitable for practical applications. First, we examine the responses of the bistable system with fixed parameters to different bit rate logic input signals, showing that an arbitrary high bit rate LSR in a bistable system cannot be achieved. Then, a normalized transform of the LSR bistable system is introduced through a kind of variable substitution. Based on the transform, it is found that LSR for arbitrary high bit rate logic signals in a bistable system can be achieved by adjusting the parameters of the system, setting bias value and amplifying the amplitudes of logic input signals and noise properly. Finally, the desired OR and AND logic outputs to high bit rate logic inputs in a bistable system are obtained by numerical simulations. The study might provide higher feasibility of LSR in practical engineering applications. Project supported by the National Natural Science Foundation of China (Grant No. 51379526).

  2. Achievable rate of cognitive radio spectrum sharing MIMO channel with space alignment and interference temperature precoding

    KAUST Repository

    Sboui, Lokman

    2013-06-01

    In this paper, we investigate the spectral efficiency gain of an uplink Cognitive Radio (CR) Multi-Input MultiOutput (MIMO) system in which the Secondary/unlicensed User (SU) is allowed to share the spectrum with the Primary/licensed User (PU) using a specific precoding scheme to communicate with a common receiver. The proposed scheme exploits at the same time the free eigenmodes of the primary channel after a space alignment procedure and the interference threshold tolerated by the PU. In our work, we study the maximum achievable rate of the CR node after deriving an optimal power allocation with respect to an outage interference and an average power constraints. We, then, study a protection protocol that considers a fixed interference threshold. Applied to Rayleigh fading channels, we show, through numerical results, that our proposed scheme enhances considerably the cognitive achievable rate. For instance, in case of a perfect detection of the PU signal, after applying Successive Interference Cancellation (SIC), the CR rate remains non-zero for high Signal to Noise Ratio (SNR) which is usually impossible when we only use space alignment technique. In addition, we show that the rate gain is proportional to the allowed interference threshold by providing a fixed rate even in the high SNR range. © 2013 IEEE.

  3. Achieving high bit rate logical stochastic resonance in a bistable system by adjusting parameters

    Institute of Scientific and Technical Information of China (English)

    杨定新; 谷丰收; 冯国金; 杨拥民

    2015-01-01

    The phenomenon of logical stochastic resonance (LSR) in a nonlinear bistable system is demonstrated by numerical simulations and experiments. However, the bit rates of the logical signals are relatively low and not suitable for practical applications. First, we examine the responses of the bistable system with fixed parameters to different bit rate logic input signals, showing that an arbitrary high bit rate LSR in a bistable system cannot be achieved. Then, a normalized transform of the LSR bistable system is introduced through a kind of variable substitution. Based on the transform, it is found that LSR for arbitrary high bit rate logic signals in a bistable system can be achieved by adjusting the parameters of the system, setting bias value and amplifying the amplitudes of logic input signals and noise properly. Finally, the desired OR and AND logic outputs to high bit rate logic inputs in a bistable system are obtained by numerical simulations. The study might provide higher feasibility of LSR in practical engineering applications.

  4. Full-Rate Full-Diversity Achieving MIMO Precoding with Partial CSIT

    CERN Document Server

    Dutta, Biswajit; Chockalingam, A

    2011-01-01

    In this paper, we consider a $n_t\\times n_r$ multiple-input multiple-output (MIMO) channel subjected to block fading. Reliability (in terms of achieved diversity order) and rate (in number of symbols transmitted per channel use) are of interest in such channels. We propose a new precoding scheme which achieves both full diversity ($n_tn_r$th order diversity) as well as full rate ($n_t$ symbols per channel use) using partial channel state information at the transmitter (CSIT), applicable in MIMO systems including $n_rachieves full diversity and improved coding gain through an optimization over the choice of constellation sets. The optimization maximizes $d_{min}^2$ for our precoding scheme subject to an energy constraint. The scheme requires feedback of $n_t-1$ angle parameter values, compared to $2n_tn_r$ real coefficients in case of full CSIT. Error rate performance results for $3\\times 1$, $3\\times 2$, $4\\times 1$, $8\\times 1$ precoded MIMO systems (with $n_t=3,...

  5. Achievable Rates of Secure Transmission in Gaussian MISO Channel with Imperfect Main Channel Estimation

    KAUST Repository

    Zhou, Xinyu

    2016-03-15

    A Gaussian multiple-input single-output (MISO) fading channel is considered. We assume that the transmitter, in addition to the statistics of all channel gains, is aware instantaneously of a noisy version of the channel to the legitimate receiver. On the other hand, the legitimate receiver is aware instantaneously of its channel to the transmitter, whereas the eavesdropper instantaneously knows all channel gains. We evaluate an achievable rate using a Gaussian input without indexing an auxiliary random variable. A sufficient condition for beamforming to be optimal is provided. When the number of transmit antennas is large, beamforming also turns out to be optimal. In this case, the maximum achievable rate can be expressed in a simple closed form and scales with the logarithm of the number of transmit antennas. Furthermore, in the case when a noisy estimate of the eavesdropper’s channel is also available at the transmitter, we introduce the SNR difference and the SNR ratio criterions and derive the related optimal transmission strategies and the corresponding achievable rates.

  6. Achievable Rates of Cognitive Radio Networks Using Multi-Layer Coding with Limited CSI

    KAUST Repository

    Sboui, Lokman

    2016-03-01

    In a Cognitive Radio (CR) framework, the channel state information (CSI) feedback to the secondary transmitter (SU Tx) can be limited or unavailable. Thus, the statistical model is adopted in order to determine the system performance using the outage concept. In this paper, we adopt a new approach using multi-layer-coding (MLC) strategy, i.e., broadcast approach, to enhance spectrum sharing over fading channels. First, we consider a scenario where the secondary transmitter has no CSI of both the link between SU Tx and the primary receiver (cross-link) and its own link. We show that using MLC improves the cognitive rate compared to the rate provided by a singlelayer- coding (SLC). In addition, we observe numerically that 2-Layer coding achieves most of the gain for Rayleigh fading. Second, we analyze a scenario where SU Tx is provided by partial CSI about its link through quantized CSI. We compute its achievable rate adopting the MLC and highlight the improvement over SLC. Finally, we study the case in which the cross-link is perfect, i.e., a cooperative primary user setting, and compare the performance with the previous cases. We present asymptotic analysis at high power regime and show that the cooperation enhances considerably the cognitive rate at high values of the secondary power budget.

  7. Achievable Rate of a Cognitive MIMO Multiple Access Channel With Multi-Secondary Users

    KAUST Repository

    Sboui, Lokman

    2015-03-01

    We study the secondary sum-rate of an underlay cognitive multiple access channel consisting of a primary user and multiple secondary users (SUs) communicating with a common destination. We propose a particular linear precoding and SU selection scheme that maximize the cognitive sum-rate. This scheme is based on space alignment strategy allowing SUs to share the spectrum without interfering with each other. We derive the optimal power allocation for each selected SU after applying perfect or imperfect successive interference cancellation. Numerical results show that the proposed scheme provides a significant sum-rate improvement as the number of SUs increases. In addition, it achieves almost the same performance as an exhaustive search selection, mainly in low and high power ranges. © 1997-2012 IEEE.

  8. On achievable rate of two-way relaying cognitive radio with space alignment

    KAUST Repository

    Sboui, Lokman

    2015-09-11

    We study a multiple-antenna two-way relaying (TWR) spectrum sharing system. A space alignment (SA) technique is adopted by the secondary users (SU\\'s) to avoid interference with the primary users (PU\\'s). We derive the optimal power allocation that maximizes the TWR achievable sum-rate of the SU while respecting the total power budget and the relay power constraints. In the numerical results, we quantify the sum-rate gain of using the SA in the TWR CR and we show that the SU sum-rate is very limited when the relay power is low or the PU\\'s power and its resulting interference is high. © 2015 IEEE.

  9. Improved achievable secrecy rate of visible light communication with cooperative jamming

    KAUST Repository

    Zaid, Hajar

    2016-02-25

    In this paper we study the problem of securing a visible light communication (VLC) link against passive eavesdropping, with the help of a (friendly) jammer. Differently from radio frequency (RF) communications, VLC imposes a peak amplitude constraint on the input distribution which renders Gaussian inputs not admissible. We provide an achievable secrecy rate that improves upon a recently established one in a concurrent work by Mostafa and Lampe. Our scheme follows from both the secrecy capacity result by Wyner and the artificial noise scheme by Goel and Negi, but using truncated Gaussian input distributions instead of uniform ones. Via numerical results, we show that our secrecy rate outperforms the concurrent rate in different settings. © 2015 IEEE.

  10. Strategies for achieving a high response rate in a home interview survey

    Directory of Open Access Journals (Sweden)

    Power Kevin

    2009-06-01

    Full Text Available Abstract Background Response rates in surveys have been falling over the last 20 years, leading to the need for novel approaches to enhance recruitment. This study describes strategies used to maximise recruitment to a home interview survey of mothers with young children living in areas of high deprivation. Methods Mothers of two year old children received a letter from their GP inviting them to take part in a survey on diet. Participants were subsequently recruited by a researcher. The researcher first tried to contact potential participants by telephone, to discuss the study and make an appointment to conduct a home interview. Where telephone numbers for women could not be obtained from GP records, web searches of publicly available databases were conducted. After obtaining correct telephone numbers, up to six attempts were made to establish contact by telephone. If this was unsuccessful, a postal request for telephone contact was made. Where no telephone contact was achieved, the researcher sent up to two appointments by post to conduct a home interview. Results Participating GPs invited 372 women to take part in a home based interview study. GP practices provided telephone numbers for 162 women, of which 134 were valid numbers. The researcher identified a further 187 numbers from electronic directories. Further searches of GP records by practice staff yielded another 38 telephone numbers. Thus, telephone numbers were obtained for 99% of potential participants. The recruitment rate from telephone contacts was 77%. Most of the gain was achieved within four calls. For the remaining women, contact by post and home visits resulted in 18 further interviews, corresponding to 35% of the women not recruited by telephone. The final interview rate was 82%. This was possible because personal contact was established with 95% of potential participants. Conclusion This study achieved a high response rate in a hard to reach group. This was mainly achieved

  11. Regional Crime Rates and Fear of Crime: WISIND Findings

    OpenAIRE

    Bug, Mathias; Kroh, Martin; Meier, Kristina

    2015-01-01

    Many people are afraid of falling prey to crime. The present report investigates the extent to which this fear is in line with the actual regional crime rates. This analysis is based on data from a comprehensive database on the fear of crime, combined with police crime statistics (specifically, adjusted crime statistics which factor in the "dark figure" of unreported crime). No evidence was found to support the (occasionally voiced) contention that the fear of falling prey to crime is irratio...

  12. Regional crime rates and fear of crime: WISIND findings

    OpenAIRE

    Bug, Mathias; Kroh, Martin; Meier, Kristina

    2015-01-01

    Many people are afraid of falling prey to crime. The present report investigates the extent to which this fear is in line with the actual regional crime rates. This analysis is based on data from a comprehensive database on the fear of crime, combined with police crime statistics (specifically, adjusted crime statistics which factor in the "dark figure" of unreported crime). No evidence was found to support the (occasionally voiced) contention that the fear of falling prey to crime is irratio...

  13. Regional lumbar motion and patient-rated outcomes

    DEFF Research Database (Denmark)

    Mieritz, Rune M; Bronfort, Gert; Hartvigsen, Jan

    2014-01-01

    OBJECTIVE: The purpose of this study was to examine the relationship in change scores between regional lumbar motion and patient-rated pain of the previous week and back-related function in chronic low back pain patients enrolled in a randomized clinical trial and treated with either exercise...... therapy or spinal manipulation using 6 different motion parameters. METHODS: Regional lumbar motions were sampled using a 6 degrees of freedom instrumented spatial linkage system in 199 participants at baseline and 12-week follow-up. The regional lumbar motion data were analyzed as a total cohort as well...... as relative to subgroup stratifications; back pain only vs back and leg pain, and treatment modality. For identifying clinically meaningful improvements in the measurements of back pain and back-related function, we used a 30% threshold. RESULTS: The relationship between change scores in patient...

  14. Achievable data rate in spectrum-sharing channels with variable-rate variable-power primary users

    KAUST Repository

    Yang, Yuli

    2012-08-01

    In this work, we propose a transmission strategy for secondary users (SUs) within a cognitive radio network where primary users (PUs) exploit variable-rate variable-power modulation. By monitoring the PU\\'s transmissions, the SU adjusts its transmit power based on the gap between the PU\\'s received effective signal-to-noise power ratio (SNR) and the lower SNR boundary for the modulation mode that is being used in the primary link. Thus, at the SU\\'s presence, the PU\\'s quality of service (QoS) is guaranteed without increasing its processing complexity thanks to no interference cancellation required in the PU\\'s operation. To demonstrate the advantage of our proposed transmission strategy, we analyze the secondary user\\'s achievable data rate by taking into account different transmission capabilities for the secondary transmitter. The corresponding numerical results not only prove the validity of our derivations but also provide a convenient tool for the network design with the proposed transmission strategy. © 2012 IEEE.

  15. Impact of Improper Gaussian Signaling on the Achievable Rate of Overlay Cognitive Radio

    KAUST Repository

    Amin, Osama

    2017-05-12

    Improper Gaussian signaling (IGS) has been recently shown to provide performance improvements in underlay cognitive radio systems as opposed to the conventional proper Gaussian signaling (PGS) scheme. For the first time, this paper implements IGS scheme in overlay cognitive radio system, where the secondary transmitter broadcasts a mixture of two different signals. The first signal is selected from the PGS scheme to support the primary message transmission. On the other hand, the second signal is chosen to be from the IGS scheme in order to reduce the interference effect on the primary receiver. We then optimally design the overlay cognitive radio that employs IGS to maximize the secondary link achievable rate while satisfying the minimum rate requirement of the primary network. In particular, we derive closed form expressions for the circularity coefficient used in the IGS scheme and the power distribution parameters. Simulation results are provided to support our theoretical derivations.

  16. Digital modulation and achievable information rates of thru-body haptic communications

    Science.gov (United States)

    Hanisch, Natalie; Pierobon, Massimiliano

    2017-05-01

    The ever increasing biocompatibility and pervasive nature of wearable and implantable devices demand novel sustainable solutions to realize their connectivity, which can impact broad application scenarios such as in the defense, biomedicine, and entertainment fields. Where wireless electromagnetic communications are facing challenges such as device miniaturization, energy scarcity, limited range, and possibility of interception, solutions not only inspired but also based on natural communication means might result into valid alternatives. In this paper, a communication paradigm where digital information is propagated through the nervous system is proposed and analyzed on the basis of achievable information rates. In particular, this paradigm is based on an analytical framework where the response of a system based on haptic (tactile) information transmission and ElectroEncephaloGraphy (EEG)-based reception is modeled and characterized. Computational neuroscience models of the somatosensory signal representation in the brain, coupled with models of the generation and propagation of somatosensory stimulation from skin mechanoreceptors, are employed in this paper to provide a proof-of-concept evaluation of achievable performance in encoding information bits into tactile stimulation, and decoding them from the recorded brain activity. Based on these models, the system is simulated and the resulting data are utilized to train a Support Vector Machine (SVM) classifier, which is finally used to provide a proof-of-concept validation of the system performance in terms of information rates against bit error probability at the reception.

  17. A Method for Achieving Constant Rotation Rates in a Micro-Orthogonal Linkage System

    Energy Technology Data Exchange (ETDEWEB)

    Dickey, F.M.; Holswade, S.C.; Romero, L.A.

    1999-05-12

    Silicon micromachine designs include engines that consist of orthog- onally oriented linear comb drive actuators mechanically connected to a rotating gear. These gears are as small as 50 {micro}m in diameter and can be driven at rotation rates exceeding 300,000 rpm. Generally, these en- gines will run with non-uniform rotation rates if the drive signals are not properly designed and maintained over a range of system parameters. We present a method for producing constant rotation rates in a micro-engine driven by an orthogonal linkage system. We show that provided the val- ues of certain masses, springs, damping factors, and lever arms are in the right proportions, the system behaves as though it were symmetrical. We will refer to systems built in this way as being quasi-symmetrical. We show that if a system is built quasi-symmetrically , then it is possible to achieve constant rotation rates even if one does not know the form of the friction function, or the value of the friction. We analyze this case in some detail.

  18. Chronostratigraphy and deposition rates in the Okinawa Trough region

    Institute of Scientific and Technical Information of China (English)

    李培英; 王永吉; 刘振夏

    1999-01-01

    Six representative cores from Okinawa Trough have been dated using AMS 14C, Standard 14C and ESR methods, and comparatively analysed. Systematic measurements of the oriented samples taken from the cores were conducted for obtaining their remnant magnetic polarity. With the aid of the dates obtained, particularly the AMS 14C ages of planktonic foraminiferal tests, two polarity events and two polar wanderings of the earth magnetic field have been defined. Calculations of the deposition rates for all the six core sites indicate rather high values in the trough plain, at least equivalent to those rates reported for the region of the East China Sea. They commonly range from 10 to 30 cm/ka, and even greater than 40 cm/ka in some localities. The deposition rate varied widely with topography and periods of time. In general, it is greater during the postglacial period than during the last glaciation. The chronostratigraphy in the Okinawa Trough region established through this study argues against the pr

  19. Video rate color region segmentation for mobile robotic applications

    Science.gov (United States)

    de Cabrol, Aymeric; Bonnin, Patrick J.; Hugel, Vincent; Blazevic, Pierre; Chetto, Maryline

    2005-08-01

    Color Region may be an interesting image feature to extract for visual tasks in robotics, such as navigation and obstacle avoidance. But, whereas numerous methods are used for vision systems embedded on robots, only a few use this segmentation mainly because of the processing duration. In this paper, we propose a new real-time (ie. video rate) color region segmentation followed by a robust color classification and a merging of regions, dedicated to various applications such as RoboCup four-legged league or an industrial conveyor wheeled robot. Performances of this algorithm and confrontation with other methods, in terms of result quality and temporal performances are provided. For better quality results, the obtained speed up is between 2 and 4. For same quality results, the it is up to 10. We present also the outlines of the Dynamic Vision System of the CLEOPATRE Project - for which this segmentation has been developed - and the Clear Box Methodology which allowed us to create the new color region segmentation from the evaluation and the knowledge of other well known segmentations.

  20. The Achievable Distortion Region of Bivariate Gaussian Source on Gaussian Broadcast Channel

    CERN Document Server

    Tian, Chao; Shamai, Shlomo

    2010-01-01

    We provide a complete characterization of the achievable distortion region for the problem of sending a bivariate Gaussian source over bandwidth-matched Gaussian broadcast channels, where each receiver is interested in only one component of the source. This setting naturally generalizes the simple single Gaussian source bandwidth-matched broadcast problem for which the uncoded scheme is known to be optimal. We show that a hybrid scheme can achieve the optimum for the bivariate case, but neither an uncoded scheme alone nor a separation-based scheme alone is sufficient. We further show that in this joint source channel coding setting, the Gaussian setting is the worst scenario among the sources and channel noises with the same covariances.

  1. Distributed Space-Time Block Coded Transmission with Imperfect Channel Estimation: Achievable Rate and Power Allocation

    Directory of Open Access Journals (Sweden)

    Sonia Aïssa

    2008-05-01

    Full Text Available This paper investigates the effects of channel estimation error at the receiver on the achievable rate of distributed space-time block coded transmission. We consider that multiple transmitters cooperate to send the signal to the receiver and derive lower and upper bounds on the mutual information of distributed space-time block codes (D-STBCs when the channel gains and channel estimation error variances pertaining to different transmitter-receiver links are unequal. Then, assessing the gap between these two bounds, we provide a limiting value that upper bounds the latter at any input transmit powers, and also show that the gap is minimum if the receiver can estimate the channels of different transmitters with the same accuracy. We further investigate positioning the receiving node such that the mutual information bounds of D-STBCs and their robustness to the variations of the subchannel gains are maximum, as long as the summation of these gains is constant. Furthermore, we derive the optimum power transmission strategy to achieve the outage capacity lower bound of D-STBCs under arbitrary numbers of transmit and receive antennas, and provide closed-form expressions for this capacity metric. Numerical simulations are conducted to corroborate our analysis and quantify the effects of imperfect channel estimation.

  2. Interference Channel with Generalized Feedback (a.k.a. with source cooperation). Part I: Achievable Region

    CERN Document Server

    Yang, Echo

    2010-01-01

    An Interference Channel with Generalized Feedback (IFC-GF) is a model for a wireless network where several source-destination pairs compete for the same channel resources, and where the sources have the ability to sense the current channel activity. The signal overheard from the channel provides information about the activity of the other users, and thus furnishes the basis for cooperation. In this two-part paper we study achievable strategies and outer bounds for a general IFC-GF with two source-destination pairs. We then evaluate the proposed regions for the Gaussian channel. Part I: achievable region. We propose that the generalized feedback is used to gain knowledge about the message sent by other user and then exploited in two ways: (a) to {\\em relay} the messages that can be decoded at both destinations--thus realizing the gains of beam-forming of a distributed multi-antenna system--and (b) to {\\em hide} the messages that can not be decoded at the non-intended destination--thus leveraging the interferen...

  3. Few Atomic Layered Lithium Cathode Materials to Achieve Ultrahigh Rate Capability in Lithium-Ion Batteries.

    Science.gov (United States)

    Tai, Zhixin; Subramaniyam, Chandrasekar M; Chou, Shu-Lei; Chen, Lingna; Liu, Hua-Kun; Dou, Shi-Xue

    2017-09-01

    The most promising cathode materials, including LiCoO2 (layered), LiMn2 O4 (spinel), and LiFePO4 (olivine), have been the focus of intense research to develop rechargeable lithium-ion batteries (LIBs) for portable electronic devices. Sluggish lithium diffusion, however, and unsatisfactory long-term cycling performance still limit the development of present LIBs for several applications, such as plug-in/hybrid electric vehicles. Motivated by the success of graphene and novel 2D materials with unique physical and chemical properties, herein, a simple shear-assisted mechanical exfoliation method to synthesize few-layered nanosheets of LiCoO2 , LiMn2 O4 , and LiFePO4 is used. Importantly, these as-prepared nanosheets with preferred orientations and optimized stable structures exhibit excellent C-rate capability and long-term cycling performance with much reduced volume expansion during cycling. In particular, the zero-strain insertion phenomenon could be achieved in 2-3 such layers of LiCoO2 electrode materials, which could open up a new way to the further development of next-generation long-life and high-rate batteries. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. ANALYSIS OF ACTIVITIES PROVIDING IMPACT ON TUBERCULOSIS MORTALITY RATE ESTIMATION IN THE REGIONS WITHIN SIBERIAN FEDERAL DISTRICT

    Directory of Open Access Journals (Sweden)

    O. V. Revyakina

    2016-01-01

    Full Text Available Basing on the data about achievement of targeted rates for efficiency evaluation of the actions aimed at tuberculosis mortality reduction in 2015 and statistic rates for 2014-2015 in 12 regions within Siberian Federal District, the impact of organizational medical activities performed by primary medical services and tuberculosis control services was analyzed in the respect of tuberculosis mortality rate. The article presents results of ranging of regions within Siberian Federal District as per tuberculosis mortality rate and indicators providing impact on the number of those died of tuberculosis.

  5. Achievable information rates calculation for optical OFDM few-mode fiber long-haul transmission systems.

    Science.gov (United States)

    Lin, Changyu; Djordjevic, Ivan B; Zou, Ding

    2015-06-29

    We propose a method to estimate the lower bound of achievable information rates (AIRs) of high speed orthogonal frequency-division multiplexing (OFDM) in spatial division multiplexing (SDM) optical long-haul transmission systems. The estimation of AIR is based on the forward recursion of multidimensional super-symbol efficient sliding-window Bahl-Cocke-Jelinek-Raviv (BCJR) algorithm. We consider most of the degradations of fiber links including nonlinear effects in few-mode fiber (FMF). This method does not consider the SDM as a simple multiplexer of independent data streams, but provides a super-symbol version for AIR calculation over spatial channels. This super-symbol version of AIR calculation algorithm, in principle, can be used for arbitrary multiple-input-multiple-output (MIMO)-SDM system with channel memory consideration. We illustrate this method by performing Monte Carlo simulations in a complete FMF model. Both channel model and algorithm for calculation of the AIRs are described in details. We also compare the AIRs results for QPSK/16QAM in both single mode fiber (SMF)- and FMF-based optical OFDM transmission.

  6. Multiuser MIMO Downlink Made Practical: Achievable Rates with Simple Channel State Estimation and Feedback Schemes

    CERN Document Server

    Caire, Giuseppe; Kobayashi, Mari; Ravindran, Niranjay

    2007-01-01

    We consider a MIMO fading broadcast channel and compute achievable ergodic rates when channel state information is acquired at the receivers via downlink training and explicit channel feedback is performed to provide transmitter channel state information (CSIT). Both ``analog'' and quantized (digital) channel feedback are analyzed, and digital feedback is shown to be potentially superior when the feedback channel uses per channel coefficient is larger than 1. Also, we show that by proper design of the digital feedback link, errors in the feedback have a relatively minor effect even if simple uncoded modulation is used on the feedback channel. We extend our analysis to the case of fading MIMO Multiaccess Channel (MIMO-MAC) in the feedback link, as well as to the case of a time-varying channel and feedback delay. We show that by exploiting the MIMO-MAC nature of the uplink channel, a fully scalable system with both downlink multiplexing gain and feedback redundancy proportional to the number of base station ant...

  7. Full-Duplex MIMO Relaying: Achievable Rates under Limited Dynamic Range

    CERN Document Server

    Day, Brian P; Bliss, Daniel W; Schniter, Philip

    2011-01-01

    In this paper we consider the problem of full-duplex multiple-input multiple-output (MIMO) relaying between a source and destination who do not share a direct link. The principal difficulty in implementing such a system is that, due to the limited attenuation between the relay's transmit and receive antenna arrays, the relay's outgoing signal may overwhelm it's limited-dynamic-range input circuitry, making it difficult-if not impossible-to recover the desired incoming signal. While explicitly modeling transmitter/ receiver dynamic-range limitations and channel estimation error, we derive tight upper and lower bounds on the end-to-end achievable rate of decode-and-forward-based full-duplex MIMO relay systems, and propose a transmission scheme based on maximization of the lower bound. The maximization requires us to (numerically) solve a nonconvex optimization problem, for which we detail a novel approach based on bisection search and gradient projection. To gain insights into system design tradeoffs, we also d...

  8. Investigations on the heat transport capability of a cryogenic oscillating heat pipe and its application in achieving ultra-fast cooling rates for cell vitrification cryopreservation.

    Science.gov (United States)

    Han, Xu; Ma, Hongbin; Jiao, Anjun; Critser, John K

    2008-06-01

    Theoretically, direct vitrification of cell suspensions with relatively low concentrations ( approximately 1 M) of permeating cryoprotective agents (CPA) is suitable for cryopreservation of almost all cell types and can be accomplished by ultra-fast cooling rates that are on the order of 10(6-7) K/min. However, the methods and devices currently available for cell cryopreservation cannot achieve such high cooling rates. In this study, we constructed a novel cryogenic oscillating heat pipe (COHP) using liquid nitrogen as its working fluid and investigated its heat transport capability to assess its application for achieving ultra-fast cooling rates for cell cryopreservation. The experimental results showed that the apparent heat transfer coefficient of the COHP can reach 2 x 10(5) W/m(2).K, which is two orders of the magnitude higher than traditional heat pipes. Theoretical analyzes showed that the average local heat transfer coefficient in the thin film evaporation region of the COHP can reach 1.2 x 10(6) W/m(2).K, which is approximately 10(3) times higher than that achievable with standard pool-boiling approaches. Based on these results, a novel device design applying the COHP and microfabrication techniques is proposed and its efficiency for cell vitrification is demonstrated through numerical simulation. The estimated average cooling rates achieved through this approach is 10(6-7)K/min, which is much faster than the currently available methods and sufficient for achieving vitrification with relatively low concentrations of CPA.

  9. Children's Educational Completion Rates and Achievement: Implications for Ethiopia's Second Poverty Reduction Strategy (2006-10)

    NARCIS (Netherlands)

    Woldehanna, T.; Jones, N.; Bezuayehu, T.O.

    2005-01-01

    The major development objectives of the Ethiopian Government are to reduce poverty and improve primary school enrolment and educational achievement (SDPRP, 2002). However, education performance indicators show that only access¿related targets have been achieved, while educational quality declined in

  10. The Revised Behavior Problem Checklist and severely emotionally disturbed adolescents: relationship to intelligence, academic achievement, and sociometric ratings.

    Science.gov (United States)

    Hagborg, W J

    1990-02-01

    This study explored the relationship among the subscales of the Revised Behavior Problem Checklist and intelligence, academic achievement, and sociometric ratings for a sample of 62 severely emotionally disturbed adolescents enrolled in a special school. A relationship of the Attention Problems-Immaturity subscale with intelligence scores and mathematics achievement was found. Four of six subscales were found to be related to peer sociometric ratings of social acceptance, while only one subscale was related to sociometric ratings of peer acceptance of his/her classmates. These findings are discussed within the context of previous research.

  11. Benefits of achieving vigorous as well as moderate physical activity recommendations: evidence from heart rate complexity and cardiac vagal modulation.

    Science.gov (United States)

    Soares-Miranda, Luisa; Sandercock, Gavin; Vale, Susana; Silva, Pedro; Moreira, Carla; Santos, Rute; Mota, Jorge

    2011-07-01

    The aim of this study was to examine differences in traditional heart rate variability measurements and heart rate complexity (sample entropy) in young adults grouped by objectively measured achievement of either moderate or both moderate and vigorous physical activity recommendations. Of 168 young adults tested (86 females, 82 males; age 20.5 ± 1.2 years), 119 achieved only recommendations for moderate physical activity (moderate group) and 49 achieved recommendations for both moderate and vigorous physical activity (vigorous group). Analysis of covariance controlling for sex, weekly minutes of moderate physical activity, and percentage of body fat was used to assess between-group differences in heart rate variability and heart rate complexity. Logistic regression analysis was used to determine the group characteristics that best predicted high heart rate complexity and vagal indices of heart rate variability. The majority of the autonomic measures were higher (P heart rate complexity and higher heart rate variability. Young adults engaged in regular vigorous physical activity were more than twice as likely to have high heart rate complexity than those involved in predominantly moderate exercise. These findings suggest that vigorous physical activity is more closely associated with high heart rate complexity than moderate physical activity in young adults.

  12. Achieving conservation when opportunity costs are high: optimizing reserve design in Alberta's oil sands region.

    Directory of Open Access Journals (Sweden)

    Richard R Schneider

    Full Text Available Recent studies have shown that conservation gains can be achieved when the spatial distributions of biological benefits and economic costs are incorporated in the conservation planning process. Using Alberta, Canada, as a case study we apply these techniques in the context of coarse-filter reserve design. Because targets for ecosystem representation and other coarse-filter design elements are difficult to define objectively we use a trade-off analysis to systematically explore the relationship between conservation targets and economic opportunity costs. We use the Marxan conservation planning software to generate reserve designs at each level of conservation target to ensure that our quantification of conservation and economic outcomes represents the optimal allocation of resources in each case. Opportunity cost is most affected by the ecological representation target and this relationship is nonlinear. Although petroleum resources are present throughout most of Alberta, and include highly valuable oil sands deposits, our analysis indicates that over 30% of public lands could be protected while maintaining access to more than 97% of the value of the region's resources. Our case study demonstrates that optimal resource allocation can be usefully employed to support strategic decision making in the context of land-use planning, even when conservation targets are not well defined.

  13. Achieving conservation when opportunity costs are high: optimizing reserve design in Alberta's oil sands region.

    Science.gov (United States)

    Schneider, Richard R; Hauer, Grant; Farr, Dan; Adamowicz, W L; Boutin, Stan

    2011-01-01

    Recent studies have shown that conservation gains can be achieved when the spatial distributions of biological benefits and economic costs are incorporated in the conservation planning process. Using Alberta, Canada, as a case study we apply these techniques in the context of coarse-filter reserve design. Because targets for ecosystem representation and other coarse-filter design elements are difficult to define objectively we use a trade-off analysis to systematically explore the relationship between conservation targets and economic opportunity costs. We use the Marxan conservation planning software to generate reserve designs at each level of conservation target to ensure that our quantification of conservation and economic outcomes represents the optimal allocation of resources in each case. Opportunity cost is most affected by the ecological representation target and this relationship is nonlinear. Although petroleum resources are present throughout most of Alberta, and include highly valuable oil sands deposits, our analysis indicates that over 30% of public lands could be protected while maintaining access to more than 97% of the value of the region's resources. Our case study demonstrates that optimal resource allocation can be usefully employed to support strategic decision making in the context of land-use planning, even when conservation targets are not well defined.

  14. Achievement and Attrition Rate Differences between Traditional and Internet-Based Beginning Spanish Courses.

    Science.gov (United States)

    Despain, J. Scott

    2003-01-01

    Describes a 2.5 year study on the achievement and attrition ate differences between a beginning university-level Spanish course delivered in the classroom and the same course taught over the Internet. Results are discussed. (Author/VWL)

  15. Achievable rate maximization for decode-and-forward MIMO-OFDM networks with an energy harvesting relay.

    Science.gov (United States)

    Du, Guanyao; Yu, Jianjun

    2016-01-01

    This paper investigates the system achievable rate for the multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) system with an energy harvesting (EH) relay. Firstly we propose two protocols, time switching-based decode-and-forward relaying (TSDFR) and a flexible power splitting-based DF relaying (PSDFR) protocol by considering two practical receiver architectures, to enable the simultaneous information processing and energy harvesting at the relay. In PSDFR protocol, we introduce a temporal parameter to describe the time division pattern between the two phases which makes the protocol more flexible and general. In order to explore the system performance limit, we discuss the system achievable rate theoretically and formulate two optimization problems for the proposed protocols to maximize the system achievable rate. Since the problems are non-convex and difficult to solve, we first analyze them theoretically and get some explicit results, then design an augmented Lagrangian penalty function (ALPF) based algorithm for them. Numerical results are provided to validate the accuracy of our analytical results and the effectiveness of the proposed ALPF algorithm. It is shown that, PSDFR outperforms TSDFR to achieve higher achievable rate in such a MIMO-OFDM relaying system. Besides, we also investigate the impacts of the relay location, the number of antennas and the number of subcarriers on the system performance. Specifically, it is shown that, the relay position greatly affects the system performance of both protocols, and relatively worse achievable rate is achieved when the relay is placed in the middle of the source and the destination. This is different from the MIMO-OFDM DF relaying system without EH. Moreover, the optimal factor which indicates the time division pattern between the two phases in the PSDFR protocol is always above 0.8, which means that, the common division of the total transmission time into two equal phases in

  16. Families, Schools, and Children's School Achievement: A Study Based on Rural Regions in China Gansu Province

    Science.gov (United States)

    Zhijun, Sun; Zeyun, Liu; Baicai, Sun

    2015-01-01

    This paper focuses on the impact of school factors on student achievement due to differences in family backgrounds. Based on the principle of diminishing effects of school investment in children's achievement, this study built a model that includes individual characteristics, family characteristics, and school characteristics. Family and school…

  17. Achievable rate regions and outer bounds for a multi-pair bi-directional relay network

    CERN Document Server

    Kim, Sang Joon; Devroye, Natasha

    2010-01-01

    In a bi-directional relay channel, a pair of nodes wish to exchange independent messages over a shared wireless half-duplex channel with the help of relays. Recent work has mostly considered information theoretic limits of the bi-directional relay channel with two terminal nodes (or end users) and one relay. In this work we consider bi-directional relaying with one base station, multiple terminal nodes and one relay, all of which operate in half-duplex modes. We assume that each terminal node communicates with the base-station in a bi-directional fashion through the relay and do not place any restrictions on the channels between the users, relays and base-stations; that is, each node has a direct link with every other node. Our contributions are three-fold: 1) the introduction of four new temporal protocols which fully exploit the two-way nature of the data and outperform simple routing or multi-hop communication schemes by carefully combining network coding, random binning and user cooperation which exploit ...

  18. Teacher Ratings of Academic Achievement of Children between 6 and 12 Years Old from Intact and Non-Intact Families

    Science.gov (United States)

    Molepo, Lephodisa S.; Maunganidze, Levison; Mudhovozi, Pilot; Sodi, Tholene

    2010-01-01

    We investigated teacher ratings of the impact of parental divorce on academic achievement of children between 6 and 12 years old up to 12 months after their parents divorced. A purposive sample of 120 children attending four different primary schools in a small South African town took part in the study. One third (n = 40) of the children had…

  19. Achievable Rates for a Two-Relay Network with Relays-Transmitter Feedbacks

    CERN Document Server

    Tebbi, Mohammad Ali; Attari, Mahmoud Ahmadian; Aref, Mohammad Reza

    2011-01-01

    We consider a relay network with two relays and two feedback links from the relays to the sender. To obtain the achievability results, we use the compress-and-forward and the decode-and-forward strategies to superimpose facility and cooperation analogue to what proposed by Cover and El Gamal for a relay channel. In addition to random binning, we use deterministic binning to perform restricted decoding. We show how to use the feedback links for cooperation between the sender and the relays to transmit the information which is compressed in the sender and the relays.

  20. Decay Rate of Energy Eigenfunctions in Classically Energetically Inaccessible Regions

    Institute of Scientific and Technical Information of China (English)

    WANG Wen-Ge

    2004-01-01

    Classically energetically inaccessible parts of energy eigenfunctions in configuration space are studied by making use of a generalization of Brillouin-Wigner perturbation theory. Approximate formulas are proposed for describing local decaying rate of this part of energy eigenfunctions, which are useful in the study of quantum phenomena,such as tunnelling effect, and are tested in an anharmonic oscillator.

  1. Migrating Broad-billed Sandpipers achieve high fuelling rates by taking a multi-course meal

    NARCIS (Netherlands)

    Verkuil, Y.I.; Dekinga, A; Koolhaas, A; van der Winden, J; van der Have, T M; Chernichko, I I

    2006-01-01

    In spring, large numbers of migrating Broad-billed Sandpipers make a stop-over in the Sivash, a shallow lagoon system in the Crimea, Ukraine, between the Black Sea and the Sea of Azov. Observed fuelling rates are high and, in just a few weeks, the birds can build up sufficient departure mass to reac

  2. Recent Achievements in Developing Low Temperature and High Strain Rate Superplastic Materials

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper is to briefly outline our recent activities in developing low temperature or high strain rate superplastic materials, including aircraft-used and general-purpose Al- and Mg-base alloys or composites, as well as Ti3Al base intermetallic alloys. The processing routes applied included the thermomechanical treatment, equal channel angular pressing and other extrusion or forging methods.

  3. University Knowledge Spillovers & Regional Start-up Rates

    DEFF Research Database (Denmark)

    Hellerstedt, Karin; Wennberg, Karl; Frederiksen, Lars

    2014-01-01

    on entrepreneurship, we develop a theoretical framework which captures how both supply- and demand-side factors mold the regional bedrock for start-ups in knowledge-intensive industries. Using multilevel data of all knowledge-intensive start-ups across 286 Swedish municipalities between 1994 and 2002 we demonstrate...... demand-side and supply-side context than is the case for high-tech start-ups in general. Our study contributes to the growing stream of research that explains entrepreneurial activity as shaped by contextual factors, most notably academic institutions, such as universities that contribute to knowledge...

  4. Achievable Rates of MIMO Systems with Linear Precoding and Iterative LMMSE Detection

    CERN Document Server

    Yuan, Xiaojun; Kavcic, Aleksandar

    2011-01-01

    We extend the area property on an additive-white-Gaussian-noise (AWGN) channel to more general linear channel models (including inter-symbol-interference (ISI) and multiple-input multiple-output (MIMO) channels) with arbitrary input constellations. We show that the theoretical limit of a generic linear channel (i.e., the input output mutual information) can be achieved using iterative minimum mean-square error (MMSE) detection under the so-called uniform and Gaussian (UG) assumption on the messages generated in iterative detection. Our major contribution is a linear precoding (LP) technique that can asymptotically ensure the UG assumption as the transmission block length tends to infinity based on the central limit theorem. We also show that superposition coded modulation (SCM) can further help to materialize the UG assumption. Numerical results are demonstrated to verify our analysis.

  5. Regions With Low Rates of Bystander Cardiopulmonary Resuscitation (CPR) Have Lower Rates of CPR Training in Victoria, Australia.

    Science.gov (United States)

    Bray, Janet E; Straney, Lahn; Smith, Karen; Cartledge, Susie; Case, Rosalind; Bernard, Stephen; Finn, Judith

    2017-06-05

    Bystander cardiopulmonary resuscitation (CPR) more than doubles the chance of surviving an out-of-hospital cardiac arrest. Recent data have shown considerable regional variation in bystander CPR rates across the Australian state of Victoria. This study aims to determine whether there is associated regional variation in rates of CPR training and willingness to perform CPR in these communities. We categorized each Victorian postcode as either a low or high bystander CPR region using data on adult, bystander-witnessed, out-of-hospital cardiac arrests of presumed cardiac etiology (n=7175) from the Victorian Ambulance Cardiac Arrest Registry. We then surveyed adult Victorians (n=404) and compared CPR training data of the respondents from low and high bystander CPR regions. Of the 404 adults surveyed, 223 (55%) resided in regions with low bystander CPR. Compared with respondents from high bystander CPR regions, respondents residing in regions with low bystander CPR had lower rates of CPR training (62% versus 75%, P=0.009) and lower self-ratings for their overall knowledge of CPR (76% versus 84%, P=0.04). There were no differences between the regions in their reasons for not having undergone CPR training or in their willingness to perform CPR. Rates of survival for bystander-witnessed, out-of-hospital cardiac arrests were significantly lower in low bystander CPR regions (15.7% versus 17.0%, Pbystander CPR in Victoria, Australia. Targeting these regions with CPR training programs may improve bystander CPR rates and out-of-hospital cardiac arrest outcomes. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  6. 76 FR 28767 - Desert Southwest Customer Service Region-Rate Order No. WAPA-152

    Science.gov (United States)

    2011-05-18

    ... Area Power Administration Desert Southwest Customer Service Region-Rate Order No. WAPA-152 AGENCY.... FOR FURTHER INFORMATION CONTACT: Mr. Darrick Moe, Regional Manager, Desert Southwest Customer Service... moe@wapa.gov , or Mr. Jack Murray, Rates Manager, Desert Southwest Customer Service Region, Western...

  7. Review article: remission rates achievable by current therapies for inflammatory bowel disease

    OpenAIRE

    2011-01-01

    Abstract Background and Aim: To review remission rates with current medical treatments for inflammatory bowel disease (IBD). Methods We searched MEDLINE (source PUBMED, 1966 to January, 2011). Results Induction and maintenance of remission was observed in 20% (range, 9-29.5%) and 53% (range, 36.8-59.6%) of ulcerative colitis (UC) patients treated with oral 5-ASA derivatives. Induction of remission was noted in 52% (range, 48-58%) of Crohn?s disease (CD) patients and 54% of UC...

  8. Dobutamine stress echo is superior to exercise stress testing in achieving target heart rate among patients on beta blockers.

    Science.gov (United States)

    Sabbath, Adam; Pack, Michael; Markiewicz, Richard; John, Jooby; Gaballa, Mohamed; Goldman, Steven; Thai, Hoang

    2005-01-01

    Published guidelines recommend continuing beta-adrenergic receptor blockade in patients undergoing stress testing. We evaluated the role of pharmacological versus exercise stress testing in achieving target heart rate (THR) among patients on beta-adrenergic blockade. We compared data from 140 patients who underwent dobutamine stress echo (DSE) and 143 patients who underwent exercise treadmill testing (ETT). In both groups, beta-adrenergic blocker was continued at the time of stress testing. Overall, patients undergoing DSE achieved THR more frequently than ETT. With beta-adrenergic blockade, DSE patients met THR more frequently than ETT patients (p < 0.001). Without beta-adrenergic blockade, there was no difference between either modality in achieving THR. In both DSE and ETT patients, absence of beta-adrenergic blockade increased the odds of achieving THR [odds ratio (OR): 2.46, p = 0.042 and OR: 7.44, p < 0.001, respectively]. Atropine use with DSE increased the odds of achieving THR (OR: 3.76, p = 0.006). In conclusion, pharmacological stress testing appears to be superior to exercise stress testing in achieving THR among patients on beta-adrenergic blockade.

  9. An environmental assessment of risk in achieving good environmental status to support regional prioritisation of management in Europe

    NARCIS (Netherlands)

    Breen, P.; Robinson, L.A.; Rogers, S.I.; Knights, A.M.; Piet, G.J.

    2012-01-01

    The Marine Strategy Framework Directive (MSFD) aims to achieve Good Environmental Status (GES) in Europe's Seas. The requirement for regional sea authorities to identify and prioritise issues for management has meant that standardized methods to assess the current level of departure from GES are

  10. [Low rate of achieving LDL-cholesterol objective in a low income population].

    Science.gov (United States)

    Vacanti, Luciano J; Santos, Silvio C de Moraes; Fujita, Alessandro M; Lima, David S; Lopes, Alan F; Vetorazi, Rodrigo; Sellera, Ana; Scarin, Nataly R

    2005-09-01

    To assess the percentage of patients suitable to the objectives preconized by III Diretrizes sobre Dislipidemias da Sociedade Brasileira de Cardiologia (3rd Guidelines on Dyslipidemia of Brazilian Society of Cardiology), in a low income population. To determine whether there was a difference of that percentage in high risk patients, according to their age ( 75 years old). We analyzed, consecutively, 190 patients, divided in two groups: 51 low and middle risk patients (G I) and 139 high risk patients for coronary artery disease (G II). The sample was characterized by low income patients (69% for the patients had a family income between 1 and 2 minimum salaries), whose hypolipidemic therapy was irregularly supplied by the state. G I and G II showed, respectively, 70.1 +/- 13.7 years old and 13.7% of men and 68.5 +/- 10.6 years old and 62.6% of men. Among patients from G II, 30% showed LDL-cholesterol within the preconized objectives. The frequency of patients suitable to the objectives was significantly lower in individuals with 75 years of age or older than among those younger than 75 years old (16% vs. 30%, p = 0.04). In a predominantly low income population and without continuous assistance from the State to purchase statins, the achievement of preconized objectives for LDL-cholesterol, by 3rd Guidelines on Dyslipidemia of Brasilian Society of Cardiology, is low and also significantly lower among very old patients, with a high risk profile for atherosclerosis.

  11. Methodology to Achieve Enhanced Data Transmission Rate using Li-Fi in VLC Technology

    Directory of Open Access Journals (Sweden)

    Md. Shahadat Hossain,,

    2014-12-01

    Full Text Available Li-Fi (Light Fidelity or optical Wi-Fi is the transmission of data using light waves by varying the light intensity faster than human eye can follow using Visible Light Communication (VLC technology in free space. This is just like as “Data Through Illumination”. VLC uses rapid pulses of light to transmit information wirelessly. VLC using LEDs is emerging as a key technology for a ubiquitous communication system, because LED has the advantages of fast switching, long life expectancy, being less expensive and being visible light that is safe for the human body. LEDs are different from the other kinds of lamps because they are semiconductors. This characteristic gives them the capability to switch-on and off within few nanoseconds or billionth of a second. Converted in terms of data rates, this corresponds to 1 Gbits/s or more. In order to compare, at best Wi-Fi can reach 100 Mbits/s data rates and so at least 10 times or more lower. Here we shows some new conceptual methods by which we can transmit data in parallel using VLC technology. If this application is put into use, we can use every bulb like a Wi-Fi hot spot to transmit the data with ultra-high speed such as more than 10 Gbits/s.

  12. 76 FR 8730 - Desert Southwest Customer Service Region-Rate Order No. WAPA-151

    Science.gov (United States)

    2011-02-15

    ... Area Power Administration Desert Southwest Customer Service Region-Rate Order No. WAPA-151 AGENCY..., Regional Manager, Desert Southwest Customer Service Region, Western Area Power Administration, 615 South... the Desert Southwest Customer Service Regional Office, 615 South 43rd Avenue, Phoenix, Arizona. FOR...

  13. Educational Achievement of Immigrant Adolescents in Spain: Do Gender and Region of Origin Matter?

    Science.gov (United States)

    Vaquera, Elizabeth; Kao, Grace

    2012-01-01

    This study explores the educational achievement of immigrant youth in Spain employing data from 3 waves of the Longitudinal Study of Families and Childhood (Panel de Families i Infancia), a representative sample of children in Catalonia first interviewed at ages 13-16 in 2006 (N = 2,710). Results suggest consistent disadvantage in achievement…

  14. Educational Achievement of Immigrant Adolescents in Spain: Do Gender and Region of Origin Matter?

    Science.gov (United States)

    Vaquera, Elizabeth; Kao, Grace

    2012-01-01

    This study explores the educational achievement of immigrant youth in Spain employing data from 3 waves of the Longitudinal Study of Families and Childhood (Panel de Families i Infancia), a representative sample of children in Catalonia first interviewed at ages 13-16 in 2006 (N = 2,710). Results suggest consistent disadvantage in achievement…

  15. On Improving the Representation of a Region Achieved by a Sensor Network

    OpenAIRE

    Chu, Xiaoyu; Sethu, Harish

    2009-01-01

    This report considers the class of applications of sensor networks in which each sensor node makes measurements, such as temperature or humidity, at the precise location of the node. Such spot-sensing applications approximate the physical condition of the entire region of interest by the measurements made at only the points where the sensor nodes are located. Given a certain density of nodes in a region, a more spatially uniform distribution of the nodes leads to a better approximation of the...

  16. Primary Rate-Splitting Achieves Capacity for the Gaussian Cognitive Interference Channel

    CERN Document Server

    Rini, Stefano; Goldsmith, Andrea

    2012-01-01

    The cognitive interference channel models cognitive overlay radio systems, where cognitive radios overhear the transmission of neighboring nodes. Capacity for this channel is not known in general. For the Gaussian case capacity is known in three regimes, usually denoted as the "weak interference", "very strong interference" and "primary decodes cognitive". This paper provides a new capacity result, based on rate-splitting of the primary user's message into a public and private part and that generalizes the capacity results in the "very strong interference" and "primary decodes cognitive" regimes. This result indicates that capacity of the cognitive interference channel not only depends on channel conditions but also the level of cooperation with the primary user.

  17. Pareto Boundary of the Rate Region for Single-Stream MIMO Interference Channels: Linear Transceiver Design

    Science.gov (United States)

    Cao, Pan; Jorswieck, Eduard A.; Shi, Shuying

    2013-10-01

    We consider a multiple-input multiple-output (MIMO) interference channel (IC), where a single data stream per user is transmitted and each receiver treats interference as noise. The paper focuses on the open problem of computing the outermost boundary (so-called Pareto boundary-PB) of the achievable rate region under linear transceiver design. The Pareto boundary consists of the strict PB and non-strict PB. For the two user case, we compute the non-strict PB and the two ending points of the strict PB exactly. For the strict PB, we formulate the problem to maximize one rate while the other rate is fixed such that a strict PB point is reached. To solve this non-convex optimization problem which results from the hard-coupled two transmit beamformers, we propose an alternating optimization algorithm. Furthermore, we extend the algorithm to the multi-user scenario and show convergence. Numerical simulations illustrate that the proposed algorithm computes a sequence of well-distributed operating points that serve as a reasonable and complete inner bound of the strict PB compared with existing methods.

  18. Variations in breastfeeding rates for very preterm infants between regions and neonatal units in Europe

    DEFF Research Database (Denmark)

    Bonet, Mercedes; Blondel, Béatrice; Agostino, Rocco

    2011-01-01

    To compare breastfeeding rates at discharge for very preterm infants between European regions and neonatal units, and to identify characteristics associated with breast feeding using multilevel models....

  19. Increasing the rate of heating: a potential therapeutic approach for achieving synergistic tumour killing in combined hyperthermia and chemotherapy.

    Science.gov (United States)

    Tang, Yuan; McGoron, Anthony J

    2013-01-01

    A synergistic cancer cell killing effect of sub-lethal hyperthermia and chemotherapy has been reported extensively. In this study, in vitro cell culture experiments with a uterine cancer cell line (MES-SA) and its multidrug resistant (MDR) variant MES-SA/Dx5 were conducted in order to investigate the role of heating rate in achieving a synergistic effect. The mode of cell death, induction of thermal tolerance and P-glycoprotein (P-gp) mediated MDR following two different rates of heating were studied. Doxorubicin (DOX) was used as the chemotherapy drug. A rapid rate hyperthermia was achieved by near infrared laser (NIR) excited indocyanine green (ICG) dye (absorption maximum at 808 nm, ideal for tissue penetration). A slow rate hyperthermia was provided by a cell culture incubator. The potentiating effect of hyperthermia to chemotherapy can be maximised by increasing the rate of heating. When delivered at the same thermal dose, a rapid increase in temperature from 37°C to 43°C caused more cell membrane damage than gradually heating the cells from 37°C to 43°C and thus allowed for more intracellular accumulation of DOX. Meanwhile, the rapid rate laser-ICG hyperthermia at 43°C caused cell necrosis whereas the slow rate incubator hyperthermia at 43°C induced mild apoptosis. At 43°C a positive correlation between thermal tolerance and the length of hyperthermia exposure is identified. This study shows that by increasing the rate of heating, less thermal dose is needed in order to overcome P-gp mediated MDR.

  20. Space and time diversity in indoor wireless optical links achieving higher data rate

    Science.gov (United States)

    Alqudah, Yazan A.

    2013-02-01

    Multispot diffusing configuration (MSDC) in optical wireless links provide uniform optical power needed for multiaccess and spatial dependence that can be used to allow space diversity techniques over the link. The spatial channels are furnished in MSDC through utilizing multibeam transmitter that produces spatially confined diffusing spots, and a multibranch receiver with small enough branch field-of-view (FOV) to restrict the number of diffusing spots within its FOV. Here, we study different encoding techniques that use space and time diversity to reduce the bit error rate. An improved technique, constellation rotation, is proposed for pulse amplitude modulated (PAM) to increase the Euclidian distance between signal points, and thus reduce bit error. Our study shows that when a cap is placed on the amount of power allocated per channel, the performance of the improved 4-PAM using three spatial channels and soft binary decision provide the optimal performance. When the power allocated per user is restricted, the best performance is obtained through soft binary decision and by using symbols identified by their level and spatial channel to carry 2 bits per signal level-channel.

  1. Consultative Seminar Reviews Achievements and Maps Out Future Directions of Population Education in the Region.

    Science.gov (United States)

    Population Education in Asia and the Pacific Newsletter and Forum, 1990

    1990-01-01

    Reviewed are the implementation strategies and the policy trends of national and regional (western Pacific) population education programs along with the identification of new program goals and emerging needs for cooperative action among the countries in Asia which participated in the UNESCO-sponsored population education consultative seminar in…

  2. Examining the relation between ratings of executive functioning and academic achievement: findings from a cross-cultural study.

    Science.gov (United States)

    Thorell, Lisa B; Veleiro, Alberto; Siu, Angela F Y; Mohammadi, Hiwa

    2013-01-01

    The present study investigated the relation between academic performance and ratings of executive functioning in children aged 6-11 from four countries: Sweden, Spain, Iran, and China. Ratings of executive functioning were made by both parents and teachers using the Childhood Executive Functioning Inventory (CHEXI). The results showed that the Chinese sample was generally rated as having more executive deficits compared to the other samples. The finding that executive functioning deficits are exacerbated in China is most likely the result of cultural biases. Boys were generally rated as having poorer executive functioning compared to girls, except in Iran where parents, but not teachers, rated girls as having poorer executive functioning compared to boys. However, this opposite pattern of results found for Iran is not likely to reflect true gender differences in executive functioning. Despite some differences in the levels of executive functioning across countries, both the inhibition and working memory subscales of the CHEXI were related to academic achievement in all four countries, except for CHEXI parent ratings in China. Altogether, the results indicate that the CHEXI may be used as a screening measure for early academic difficulties, although cultural biases clearly have to be taken into consideration.

  3. Land Cover Mapping in Northern High Latitude Permafrost Regions with Satellite Data: Achievements and Remaining Challenges

    Directory of Open Access Journals (Sweden)

    Annett Bartsch

    2016-11-01

    Full Text Available Most applications of land cover maps that have been derived from satellite data over the Arctic require higher thematic detail than available in current global maps. A range of application studies has been reviewed, including up-scaling of carbon fluxes and pools, permafrost feature mapping and transition monitoring. Early land cover mapping studies were driven by the demand to characterize wildlife habitats. Later, in the 1990s, up-scaling of in situ measurements became central to the discipline of land cover mapping on local to regional scales at several sites across the Arctic. This includes the Kuparuk basin in Alaska, the Usa basin and the Lena Delta in Russia. All of these multi-purpose land cover maps have been derived from Landsat data. High resolution maps (from optical satellite data serve frequently as input for the characterization of periglacial features and also flux tower footprints in recent studies. The most used map to address circumpolar issues is the CAVM (Circum Arctic Vegetation Map based on AVHRR (1 km and has been manually derived. It provides the required thematic detail for many applications, but is confined to areas north of the treeline, and it is limited in spatial detail. A higher spatial resolution circumpolar land cover map with sufficient thematic content would be beneficial for a range of applications. Such a land cover classification should be compatible with existing global maps and applicable for multiple purposes. The thematic content of existing global maps has been assessed by comparison to the CAVM and regional maps. None of the maps provides the required thematic detail. Spatial resolution has been compared to used classes for local to regional applications. The required thematic detail increases with spatial resolution since coarser datasets are usually applied over larger areas covering more relevant landscape units. This is especially of concern when the entire Arctic is addressed. A spatial

  4. Morphology and mycelial growth rate of Pleurotus spp. strains from the Mexican mixtec region.

    Science.gov (United States)

    Guadarrama-Mendoza, P C; del Toro, G Valencia; Ramírez-Carrillo, R; Robles-Martínez, F; Yáñez-Fernández, J; Garín-Aguilar, M E; Hernández, C G; Bravo-Villa, G

    2014-01-01

    Two native Pleurotus spp. strains (white LB-050 and pale pink LB-051) were isolated from rotten tree trunks of cazahuate (Ipomoea murucoides) from the Mexican Mixtec Region. Both strains were chemically dedikaryotized to obtain their symmetrical monokaryotic components (neohaplonts). This was achieved employing homogenization time periods from 60 to 65 s, and 3 day incubation at 28 °C in a peptone-glucose solution (PGS). Pairing of compatible neohaplonts resulted in 56 hybrid strains which were classified into the four following hybrid types: (R(1-n)xB(1-n), R(1-n)xB(2-1), R(2-n)xB(1-n) and R(2-n)xB(2-1)). The mycelial growth of Pleurotus spp. monokaryotic and dikaryotic strains showed differences in texture (cottony or floccose), growth (scarce, regular or abundant), density (high, regular or low), and pigmentation (off-white, white or pale pink). To determine the rate and the amount of mycelium growth in malt extract agar at 28 °C, the diameter of the colony was measured every 24 h until the Petri dish was completely colonized. A linear model had the best fit to the mycelial growth kinetics. A direct relationship between mycelial morphology and growth rate was observed. Cottony mycelium presented significantly higher growth rates (p < 0.01) in comparison with floccose mycelium. Thus, mycelial morphology can be used as criterion to select which pairs must be used for optimizing compatible-mating studies. Hybrids resulting from cottony neohaplonts maintained the characteristically high growth rates of their parental strains with the hybrid R(1-n)xB(1-n) being faster than the latter.

  5. Morphology and mycelial growth rate of Pleurotus spp. strains from the Mexican mixtec region

    Directory of Open Access Journals (Sweden)

    P.C. Guadarrama-Mendoza

    2014-09-01

    Full Text Available Two native Pleurotus spp. strains (white LB-050 and pale pink LB-051 were isolated from rotten tree trunks of cazahuate (Ipomoea murucoides from the Mexican Mixtec Region. Both strains were chemically dedikaryotized to obtain their symmetrical monokaryotic components (neohaplonts. This was achieved employing homogenization time periods from 60 to 65 s, and 3 day incubation at 28 °C in a peptone-glucose solution (PGS. Pairing of compatible neohaplonts resulted in 56 hybrid strains which were classified into the four following hybrid types: (R1-n xB1-n, R1-n xB2-1, R2-n xB1-n and R2-n xB2-1. The mycelial growth of Pleurotus spp. monokaryotic and dikaryotic strains showed differences in texture (cottony or floccose, growth (scarce, regular or abundant, density (high, regular or low, and pigmentation (off-white, white or pale pink. To determine the rate and the amount of mycelium growth in malt extract agar at 28 °C, the diameter of the colony was measured every 24 h until the Petri dish was completely colonized. A linear model had the best fit to the mycelial growth kinetics. A direct relationship between mycelial morphology and growth rate was observed. Cottony mycelium presented significantly higher growth rates (p < 0.01 in comparison with floccose mycelium. Thus, mycelial morphology can be used as criterion to select which pairs must be used for optimizing compatible-mating studies. Hybrids resulting from cottony neohaplonts maintained the characteristically high growth rates of their parental strains with the hybrid R1-n xB1-n being faster than the latter.

  6. Regional analysis of big five personality factors and suicide rates in Russia.

    Science.gov (United States)

    Voracek, Martin

    2013-08-01

    Extending cross-national and intranational studies on possible aggregate-level associations between personality dimensions and suicide prevalence, this study examined the associations of the Big Five personality factors and suicide rates across 32 regions of the Russian Federation. Failing to replicate one key finding of similar geographic studies, namely, a correspondence of higher suicide rates with lower Agreeableness and Conscientiousness (i.e., higher Psychoticism) scores, higher suicide rates corresponded to higher Agreeableness scores. This effect was obtained with one available data source (regional-level Big Five ratings based on the National Character Survey), but not with another (based on the NEO-PI-R measure). All in all, regional suicide rates across Russia were dissociated from regional variation in personality dimensions.

  7. Achieving high mobility ZnO : Al at very high growth rates by dc filtered cathodic arc deposition

    Energy Technology Data Exchange (ETDEWEB)

    Mendelsberg, R J; Lim, S H N; Wallig, J; Anders, A [Lawrence Berkeley National Laboratory, Plasma Applications Group, Berkeley, CA (United States); Zhu, Y K [Harbin Institute of Technology, Harbin (China); Milliron, D J, E-mail: aanders@lbl.gov [Lawrence Berkeley National Laboratory, Molecular Foundry, Berkeley, CA (United States)

    2011-06-15

    Achieving a high growth rate is paramount for making large-area transparent conducting oxide coatings at a low cost. Unfortunately, the quality of thin films grown by most techniques degrades as the growth rate increases. Filtered dc cathodic arc is a lesser known technique which produces a stream of highly ionized plasma, in stark contrast to the neutral atoms produced by standard sputter sources. Ions bring a large amount of potential energy to the growing surface which is in the form of heat, not momentum. By minimizing the distance from cathode to substrate, the high ion flux gives a very high effective growth temperature near the film surface without causing damage from bombardment. The high surface temperature is a direct consequence of the high growth rate and allows for high-quality crystal growth. Using this technique, 500-1300 nm thick and highly transparent ZnO : Al films were grown on glass at rates exceeding 250 nm min{sup -1} while maintaining resistivity below 5 x 10{sup -4} {Omega} cm with electron mobility as high as 60 cm{sup 2} V{sup -1} s{sup -1}. (fast track communication)

  8. Power allocation and achievable data rate in spectrum-sharing channels under adaptive primary service outage constraints

    KAUST Repository

    Yang, Yuli

    2012-09-01

    In this paper, we focus on a cognitive radio network where adaptive modulation is adopted in primary links. The gap between the primary user (PU)\\'s received signal-to-noise ratio (SNR) and the lower SNR boundary of the modulation mode that is being used, provides an interference-tolerable zone. Based on this gap, a secondary user (SU) has an increased opportunity to access the licensed spectrum and to determine the transmit power it should use to keep the PU\\'s quality-of-service (QoS) unaffected. However, since the SU cannot obtain perfect information on the PU\\'s received SNR, it has to choose an SNR point between the lower and upper boundaries of the PU\\'s current modulation mode as if this point were the real SNR received by the PU. Considering this issue, in order to quantify the effect of the SU\\'s transmissions on the PU\\'s QoS, we define the PU\\'s service outage probability and obtain its closed-form expressions by taking into account whether the peak transmit power constraint is imposed on the secondary\\'s transmission or not. Subsequently, we derive the SU\\'s achievable data rate in closed form for counterpart scenarios. Numerical results provided here quantify the relation between the PU\\'s service outage probability and the SU\\'s achievable data rate, which further demonstrate that the higher the peak transmit power a secondary transmitter can support, the better performance the cognitive radio network can achieve. © 2012 IEEE.

  9. In vivo human cardiac shortening and lengthening velocity is region dependent and not coupled with heart rate: 'longitudinal' strain rate markedly underestimates apical contribution.

    Science.gov (United States)

    Stöhr, Eric J; Stembridge, Mike; Esformes, Joseph I

    2015-04-20

    What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence in vivo remains poorly understood. What is the main finding and its importance? Using resistance exercise to increase heart rate and arterial resistance physiologically in humans and measuring regional cardiac SR (at the base and apex), we found that HR and SR were not strictly coupled because SR at the base and apex responded differently, despite the same HR. Importantly, our data show that the region-averaged 'longitudinal' SR, which is currently popular in the clinical setting, markedly underestimates the contribution of the apex. The fundamental importance of cardiac shortening and lengthening velocity (i.e. strain rate; SR) has been demonstrated in vitro. Currently, the interdependence between in vivo SR and HR is poorly understood because studies have typically assessed region-averaged 'longitudinal' strain rate, which is likely to underestimate the apical contribution, and have used non-physiological interventions that may also have been influenced by multicollinearity caused by concomitant reductions in arterial resistance. Resistance exercise acutely raises HR, blood pressure and arterial resistance and transiently disassociates these cardiovascular factors following exercise. Therefore, we measured SR, HR, blood pressure and arterial resistance in nine healthy men (aged 20 ± 1 years) immediately before, during and after double-leg-press exercise at 30 and 60% of maximal strength. Resistance exercise caused a disproportionate SR response at the left ventricular base and apex (interaction effect, P < 0.05). Consequently, associations between HR and regional peak SR were inconsistent and mostly very weak (r(2)  = 0.0004-0.24). Likewise, the areas under the curve for systolic and diastolic SR and their relationship with systolic and diastolic duration

  10. Reverse sequential therapy achieves a similar eradication rate as standard sequential therapy for Helicobacter pylori eradication: a randomized controlled trial.

    Science.gov (United States)

    Tsay, Feng-Woei; Wu, Deng-Chyang; Kao, Sung-Shuo; Tsai, Tzung-Jium; Lai, Kwok-Hung; Cheng, Jin-Shiung; Chan, Hoi-Hung; Wang, Huay-Min; Tsai, Wei-Lun; Tseng, Hui-Hwa; Peng, Nan-Jin; Hsu, Ping-I

    2015-02-01

    Sequential therapy is a two-step therapy achieving a promising eradication rate for Helicobacter pylori infection. The rationale of sequential method has been proposed that amoxicillin weakens bacterial cell walls in the initial phase of treatment, preventing the development of drug efflux channels for clarithromycin and metronidazole used in the second phase. The aim of this prospective, randomized, controlled study was to investigate whether the efficacy of reverse sequential therapy was noninferior to sequential therapy in the treatment of H. pylori infection. From January 2009 to December 2010, consecutive H. pylori-infected patients were randomly assigned to receive either sequential therapy (a 5-day dual therapy with pantoprazole plus amoxicillin, followed by a 5-day triple therapy with pantoprazole plus clarithromycin and metronidazole) or reverse sequential therapy (a 5-day triple therapy with pantoprazole plus clarithromycin and metronidazole, followed by a 5-day dual therapy with pantoprazole plus amoxicillin). H. pylori status was examined 6 weeks after the end of treatment by rapid urease and histology or urea breath test. One hundred and twenty-two H. pylori-infected participants were randomized to receive sequential (n = 60) or reverse sequential therapy (n = 62). The eradication rates, by intention-to-treat analysis, were similar: 91.9% (95% confidence interval (CI): 85.1-98.7%) for sequential therapy and 96.7% (95% CI: 92.2-101.2%) for reverse sequential therapy (p = .44). Per-protocol analysis also showed similar results: 91.8% (95% CI: 84.9-98.7%) for sequential group and 96.7% (95% CI: 92.2-101.2%) for reverse sequential therapy (p = .43). The two treatments exhibited comparable frequencies of adverse events (11.3% vs 6.7%, respectively) and drug compliance (98.4% vs 100%, respectively). The overall resistance rates of antibiotics were clarithromycin 10.5%, amoxicillin 0%, and metronidazole 44.2% of patients, respectively. The dual

  11. An optimized clarithromycin-free 14-day triple therapy for Helicobacter pylori eradication achieves high cure rates in Uruguay.

    Science.gov (United States)

    Dacoll, Cristina; Sánchez-Delgado, Jordi; Balter, Henia; Pazos, Ximena; Di Pace, María; Sandoya, Gabriela; Cohen, Henry; Calvet, Xavier

    Strong acid inhibition increases cure rates with triple therapy and 14-day are more effective than 7-day treatments. The combination of amoxicillin plus metronidazole at full doses has been shown to overcome metronidazole resistance and to achieve good eradication rates even in patients harboring resistant strains. No previous studies have been reported in Latin-America with this optimized triple-therapy scheme. The aim of the present study was to assess the eradication rate and tolerance of a new first-line treatment regimen associating strong acid inhibition, amoxicillin and metronidazole. Patients from the Clínica de Gastroenterología of the Hospital de Clínicas (Montevideo, Uruguay) were included. Hp status was mainly assessed by at least one of the following: histologyor urea breath test (UBT). A 14-day treatment was prescribed comprising esomeprazole 40mg twice a day plus amoxicillin 1g and metronidazole 500mg, both three times a day. H. pylori cure was assessed by UBT. Forty-one patients were enrolled. Mean age was 53.3±13 years and 17.1% of patients were male. Main indications for treatment were: functional dyspepsia (27.5%), gastritis (45%), gastric or duodenal erosions (20%), gastric ulcer (5%) and intestinal metaplasia (2.5%). H. pylori eradication was achieved in 33 of the 37 patients who returned for follow-up. Eradication rates were 80.5% (95% CI: 68.4-92.6) by intention-to-treat (ITT) analysis and 89.2% (95% CI; 79.2-99.2) per protocol (PP). No major side effects were reported; 26 patients (65.8%) complained of mild side effects (nausea, diarrhea and headache). Cure rates of this triple therapy including esomeprazole, amoxicillin and metronidazole were 81% per ITT and the treatment was well tolerated. These optimal results with a simple clarithromycin-free triple therapy are better than described for standard triple therapy but there is still room for improvement to reach the desired target of 90% per ITT. Copyright © 2017 Elsevier España, S

  12. Approximating the Gaussian Multiple Description Rate Region Under Symmetric Distortion Constraints

    CERN Document Server

    Tian, Chao; Diggavi, Suhas N

    2008-01-01

    We consider multiple description coding for the Gaussian source with K descriptions under the symmetric mean squared error distortion constraints, and provide an approximate characterization of the rate region. We show that the rate region can be sandwiched between two polytopes, between which the gap can be upper bounded by constants dependent on the number of descriptions, but independent of the exact distortion constraints. Underlying this result is an exact characterization of the lossless multi-level diversity source coding problem: a lossless counterpart of the MD problem. This connection provides a polytopic template for the inner and outer bounds to the rate region. In order to establish the outer bound, we generalize Ozarow's technique to introduce a strategic expansion of the original probability space by more than one random variables. For the symmetric rate case with any number of descriptions, we show that the gap between the upper bound and the lower bound for the individual description rate is ...

  13. Regional variation in hospital admission rates in the Netherlands, Belgium, Northern France and Nordrhein-Westfalen.

    NARCIS (Netherlands)

    Noordt, M. van; Zee, J. van der; Groenewegen, P.P.

    1992-01-01

    For the analysis of regional variations in hospital admission rates a model was set up, including both supply and demand indicators. Data were gathered for regions in four health care systems (the Dutch, Belgian, French and German), for 1982, 1979, 1974 (France 1982 only). Hospital bed supply proved

  14. Fistulotomy in the tertiary setting can achieve high rates of fistula cure with an acceptable risk of deterioration in continence.

    Science.gov (United States)

    Tozer, P; Sala, S; Cianci, V; Kalmar, K; Atkin, G K; Rahbour, G; Ranchod, P; Hart, A; Phillips, R K S

    2013-11-01

    Surgery is the mainstay of treatment of anal fistulas. Low fistulas are often laid open, but higher fistulas present a more difficult problem. Patient choice centres on a compromise between risk of recurrence and risk of impairment of continence. We aimed to determine the efficacy and safety of fistulotomy at a tertiary referral centre, in particular the additional risk of impairment of continence following fistulotomy of the often recurrent, multiply-operated patients seen. Patients undergoing surgery under the senior author (RKSP) for an anal fistula during the study period (2005-2006) were identified, and a thorough review of the patients' clinical records was undertaken. Demographic, fistula anatomy, treatment and follow-up data were obtained. Eighty-four patients underwent either fistulotomy (50), insertion of permanent loose (drainage) seton (28) or EUA with or without drainage of abscess. Mean length of follow up was 11 months (SD 14.22). In the fistulotomy group, we found an overall success rate of 93 %. Secondary extensions were associated with failure to achieve cure (P = 0.008). Nine patients (20 %) suffered deterioration in continence after surgery. A longer time to referral was associated with impaired final continence. In the group referred from a surgeon in secondary care, 91 % of patients were cured, and continence impairment (mostly minor) rose from 32 % at referral to 40 % after surgery. We have shown that it is safe and reasonable to offer fistulotomy to appropriate patients despite previous surgery and within the tertiary setting. By so doing, a very high rate of healing can be achieved in patients who have previously failed. The additional risk of impairment of continence is around one in five, and in the majority will represent only minor incontinence.

  15. 30 CFR 250.1159 - May the Regional Supervisor limit my well or reservoir production rates?

    Science.gov (United States)

    2010-07-01

    ... based on well tests and any limitations imposed by well and surface equipment, sand production... reservoir production rates? 250.1159 Section 250.1159 Mineral Resources MINERALS MANAGEMENT SERVICE... Gas Production Requirements Production Rates § 250.1159 May the Regional Supervisor limit my well...

  16. Energy spectrum measurement and dose rate estimation of natural neutrons in Tibet region

    Institute of Scientific and Technical Information of China (English)

    吴建华; 徐勇军; 刘森林; 汪传高

    2015-01-01

    In this work, natural neutron spectra at nine sites in Tibet region were measured using a multi-sphere neutron spectrometer. The altitude-dependence of the spectra total fluence rate and ambient dose equivalent rate were analyzed. From the normalized natural neutron spectra at different altitudes, the spectrum fractions for neutrons of greater than 0.1 MeV do not differ obviously, while those of the thermal neutrons differ greatly from each other. The total fluence rate, effective dose rate and the ambient dose equivalent rate varied with the altitude according to an exponential law.

  17. Differential rotation rates for short-lived regions of emerging magnetic flux. [in sun

    Science.gov (United States)

    Golub, L.; Vaiana, G. S.

    1978-01-01

    We have measured the synodic rotation rates of a sample of compact X-ray emission features lasting from 1 day to 7 days, thus bridging the transition between X-ray bright points and active regions. The rotation rate is found to be a function of the lifetime, or size, of the feature; shorter-lived smaller features rotate more slowly than long-lived ones. The rotation rate for features lasting 2 days or less is consistent with that of the photospheric gas. The longest-lived features rotate at a rate about 5% higher, consistent with the sunspot rotation rate.

  18. Quantitative regional validation of the visual rating scale for posterior cortical atrophy

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, Christiane; Benedictus, Marije R.; Koedam, Esther L.G.M.; Scheltens, Philip [VU University Medical Center, Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, P.O. Box 7057, Amsterdam (Netherlands); Flier, Wiesje M. van der [VU University Medical Center, Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, P.O. Box 7057, Amsterdam (Netherlands); VU University Medical Center, Department of Epidemiology and Biostatistics, Neuroscience Campus Amsterdam, P.O. Box 7057, Amsterdam (Netherlands); Versteeg, Adriaan; Wattjes, Mike P.; Barkhof, Frederik [VU University Medical Center, Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, P.O. Box 7057, Amsterdam (Netherlands); Vrenken, Hugo [VU University Medical Center, Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, P.O. Box 7057, Amsterdam (Netherlands); VU University Medical Center, Department of Physics and Medical Technology, Neuroscience Campus Amsterdam, P.O. Box 7057, Amsterdam (Netherlands)

    2014-02-15

    Validate the four-point visual rating scale for posterior cortical atrophy (PCA) on magnetic resonance images (MRI) through quantitative grey matter (GM) volumetry and voxel-based morphometry (VBM) to justify its use in clinical practice. Two hundred twenty-nine patients with probable Alzheimer's disease and 128 with subjective memory complaints underwent 3T MRI. PCA was rated according to the visual rating scale. GM volumes of six posterior structures and the total posterior region were extracted using IBASPM and compared among PCA groups. To determine which anatomical regions contributed most to the visual scores, we used binary logistic regression. VBM compared local GM density among groups. Patients were categorised according to their PCA scores: PCA-0 (n = 122), PCA-1 (n = 143), PCA-2 (n = 79), and PCA-3 (n = 13). All structures except the posterior cingulate differed significantly among groups. The inferior parietal gyrus volume discriminated the most between rating scale levels. VBM showed that PCA-1 had a lower GM volume than PCA-0 in the parietal region and other brain regions, whereas between PCA-1 and PCA-2/3 GM atrophy was mostly restricted to posterior regions. The visual PCA rating scale is quantitatively validated and reliably reflects GM atrophy in parietal regions, making it a valuable tool for the daily radiological assessment of dementia. (orig.)

  19. The effect on pregnancy rates of tubal perfusion pressure reductions achieved by guide-wire tubal catheterization.

    Science.gov (United States)

    Papaioannou, Spyros; Afnan, Masoud; Girling, Alan J; Coomarasamy, Aravinthan; Ola, Bolarinde; Olufowobi, Olufemi; McHugo, Josephine M; Hammadieh, Nahed; Sharif, Khaldoun

    2002-08-01

    Selective salpingography enables us to measure the Fallopian tube perfusion pressure which, when high, can be effectively reduced with the use of transcervical guide-wire tubal catheterization. Whether fertility prognosis improves as a result is currently unknown. Our objective was to clarify the issue. Infertile women undergoing selective salpingography were classified into poor, mediocre and good tubal perfusion pressure groups, based on the distribution of tubal perfusion pressures in an unselected infertile population. Of 325 women, 150 (46.1%) were classified in the poor group and underwent guide-wire tubal catheterization. Complete pregnancy and tubal perfusion pressure data were available for 104 (69.4%) subjects. Following tubal catheterization, 29 women (group A) could be classified in the good, 25 (group B) in the mediocre, while 50 women (group C) remained in the poor tubal perfusion pressure group. Survival analysis showed that the pregnancy rate in group A was significantly higher than the rates in groups B and C (P = 0.036 and 0.005 respectively). Reductions of tubal perfusion pressures achieved with transcervical guide-wire tubal catheterization resulted in an improved fertility prognosis for women. Selective salpingography and tubal catheterization might have a wider role in the management of the infertile couple than currently believed.

  20. Estimating the possible range of recycling rates achieved by dump waste pickers: The case of Bantar Gebang in Indonesia.

    Science.gov (United States)

    Sasaki, Shunsuke; Araki, Tetsuya

    2014-06-01

    This article presents informal recycling contributions made by scavengers in the surrounding area of Bantar Gebang final disposal site for municipal solid waste generated in Jakarta. Preliminary fieldwork was conducted through daily conversations with scavengers to identify recycling actors at the site, and then quantitative field surveys were conducted twice. The first survey (n = 504 households) covered 33% of all households in the area, and the second survey (n = 69 households) was conducted to quantify transactions of recyclables among scavengers. Mathematical equations were formulated with assumptions made to estimate the possible range of recycling rates achieved by dump waste pickers. Slightly over 60% of all respondents were involved in informal recycling and over 80% of heads of households were waste pickers, normally referred to as live-in waste pickers and live-out waste pickers at the site. The largest percentage of their spouses were family workers, followed by waste pickers and housewives. Over 95% of all households of respondents had at least one waste picker or one small boss who has a coequal status of a waste picker. Average weight of recyclables collected by waste pickers at the site was estimated to be approximately 100 kg day(-1) per household on the net weight basis. The recycling rate of solid wastes collected by all scavengers at the site was estimated to be in the range of 2.8-7.5% of all solid wastes transported to the site.

  1. Expanding the donor pool: regional variation in pediatric organ donation rates.

    Science.gov (United States)

    Godown, Justin; McKane, Meghann; Wujcik, Kari; Mettler, Bret A; Dodd, Debra A

    2016-12-01

    There are limited published data on pediatric organ donation rates. The aim of this study was to describe the trends in pediatric organ donation over time and to assess the regional variation in pediatric deceased organ donation. OPTN data were utilized to assess the trends in pediatric organ donation over time. The number of deceased pediatric organ donors was indexed using regional mortality data obtained from the National Center for Health Statistics and compared across UNOS regions and two different eras. The number of pediatric deceased organ donors has declined in the recent era, largely driven by fewer adolescent donors. For all age groups, there is significant regional variation in organ donation rates, with identifiable high- and low-performing regions. Expansion of the donor pool may be possible by optimizing organ donation in regions demonstrating lower recruitment of pediatric donors. Using the region with the highest donation rate for each age group as the gold standard, we estimate a potential 24% increase in the number of donors if all regions performed comparably, equating to 215 new pediatric donors annually.

  2. A Rate-Distortion Optimized Coding Method for Region of Interest in Scalable Video Coding

    Directory of Open Access Journals (Sweden)

    Hongtao Wang

    2015-01-01

    original ones is also considered during rate-distortion optimization so that a reasonable trade-off between coding efficiency and decoding drift can be made. Besides, a new Lagrange multiplier derivation method is developed for further coding performance improvement. Experimental results demonstrate that the proposed method achieves significant bitrate saving compared to existing methods.

  3. The Regional Centralization of Electronic Fetal Heart Rate Monitoring and Its Impact on Neonatal Acidemia and the Cesarean Birth Rate

    Directory of Open Access Journals (Sweden)

    Kaori Michikata

    2016-01-01

    Full Text Available Objective. The improvement of the accuracy of fetal heart rate (FHR pattern interpretation to improve perinatal outcomes remains an elusive challenge. We examined the impact of an FHR centralization system on the incidence of neonatal acidemia and cesarean births. Methods. We performed a regional, population-based, before-and-after study of 9,139 deliveries over a 3-year period. The chi-squared test was used for the statistical analysis. Results. The before-and-after study showed no difference in the rates of acidemia, cesarean births, or perinatal death in the whole population. A subgroup analysis using the 4 hospitals in which an FHR centralization system was continuously connected (compliant group and 3 hospitals in which the FHR centralization system was connected on demand (noncompliant group showed that the incidence acidemia was significantly decreased (from 0.47% to 0.11% without a corresponding increase in the cesarean birth rate due to nonreassuring FHR patterns in the compliant group. Although there was no difference in the incidence of nonreassuring FHR patterns in the noncompliant group, the total cesarean birth rate was significantly higher than that in the compliant group. Conclusion. The continuous FHR centralization system, in which specialists help to interpret results and decide clinical actions, was beneficial in reducing the incidence of neonatal acidemia (pH < 7.1 without increasing the cesarean birth rate due to nonreassuring FHR patterns.

  4. Stigma, Attitudes, and Help-Seeking Intentions for Psychological Problems in Relation to Regional Suicide Rates.

    Science.gov (United States)

    Reynders, Alexandre; Kerkhof, Ad J F M; Molenberghs, Geert; Van Audenhove, Chantal

    2016-02-01

    In this ecological study, we investigated whether help-seeking related to stigma, intentions, and attitudes toward suicide are associated with the suicide rates of 20 regions within the Netherlands and Belgium. Significant associations were found between regional suicide rates and the intention to seek informal help (β = -1.47, p = .001), self-stigma (β = 1.33, p = .038), and shame (β = .71, p = .030). The association between self-stigma and suicide rate was mediated by intentions to seek informal help. These results suggest that to promote suicide prevention at the level of the regional population, stigma, shame, and intentions to seek help should be targeted in the public domain.

  5. Role of amplifiers gain on the achievable information rate of M-ary PSK and QAM constellations

    Science.gov (United States)

    Silva, Nuno A.; Pinto, Armando N.

    2017-01-01

    The impact of optical amplification on the achievable information rate (AIR) is evaluated, considering continuous and discrete modulation formats. The theoretical model for the AIR considers the optical amplification noise, the nonlinear optical noise, and the coherent receiver shot and thermal noise sources. Two different scenarios for the AIR are analyzed. First, we admit that the gain of each optical amplifier under or over compensate the previous fiber span loss. After that, we consider the case where we remove optical amplifiers from the transmission link. Results show that for the first scenario, when we under or over compensate the span loss the AIR tends to decrease. Nevertheless, for low cardinality constellations the AIR is not primarily limited by the gain of the optical amplifiers. In the second scenario, results show that it is possible to remove amplification stages from the end to the beginning of the transmission link without decreasing the AIR. We observe that for a polarization multiplexing (PM) 4-PSK constellation the plateau of 4 bits/symbol is preserved even if we remove the last two amplifiers from the transmission link.

  6. Accelerating regional atrophy rates in the progression from normal aging to Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Sluimer, Jasper D. [VU University Medical Centre, Department of Diagnostic Radiology, Amsterdam (Netherlands); VU University Medical Centre, Alzheimer Centre, Amsterdam (Netherlands); VU University Medical Centre, Image Analysis Centre, Amsterdam (Netherlands); VU University Medical Centre, Department of Diagnostic Radiology and Alzheimer Centre, PO Box 7057, Amsterdam (Netherlands); Flier, Wiesje M. van der; Scheltens, Philip [VU University Medical Centre, Alzheimer Centre, Amsterdam (Netherlands); VU University Medical Centre, Department of Neurology, Amsterdam (Netherlands); Karas, Giorgos B.; Barkhof, Frederik [VU University Medical Centre, Department of Diagnostic Radiology, Amsterdam (Netherlands); VU University Medical Centre, Alzheimer Centre, Amsterdam (Netherlands); VU University Medical Centre, Image Analysis Centre, Amsterdam (Netherlands); Schijndel, Ronald van [VU University Medical Centre, Image Analysis Centre, Amsterdam (Netherlands); VU University Medical Centre, Department of Informatics, Amsterdam (Netherlands); Barnes, Josephine; Boyes, Richard G. [UCL, Institute of Neurology, Dementia Research Centre, London (United Kingdom); Cover, Keith S. [VU University Medical Centre, Department of Physics and Medical Technology, Amsterdam (Netherlands); Olabarriaga, Silvia D. [University of Amsterdam, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam (Netherlands); Fox, Nick C. [VU University Medical Centre, Department of Neurology, Amsterdam (Netherlands); UCL, Institute of Neurology, Dementia Research Centre, London (United Kingdom); Vrenken, Hugo [VU University Medical Centre, Alzheimer Centre, Amsterdam (Netherlands); VU University Medical Centre, Image Analysis Centre, Amsterdam (Netherlands); VU University Medical Centre, Department of Physics and Medical Technology, Amsterdam (Netherlands)

    2009-12-15

    We investigated progression of atrophy in vivo, in Alzheimer's disease (AD), and mild cognitive impairment (MCI). We included 64 patients with AD, 44 with MCI and 34 controls with serial MRI examinations (interval 1.8 {+-} 0.7 years). A nonlinear registration algorithm (fluid) was used to calculate atrophy rates in six regions: frontal, medial temporal, temporal (extramedial), parietal, occipital lobes and insular cortex. In MCI, the highest atrophy rate was observed in the medial temporal lobe, comparable with AD. AD patients showed even higher atrophy rates in the extramedial temporal lobe. Additionally, atrophy rates in frontal, parietal and occipital lobes were increased. Cox proportional hazard models showed that all regional atrophy rates predicted conversion to AD. Hazard ratios varied between 2.6 (95% confidence interval (CI) = 1.1-6.2) for occipital atrophy and 15.8 (95% CI = 3.5-71.8) for medial temporal lobe atrophy. In conclusion, atrophy spreads through the brain with development of AD. MCI is marked by temporal lobe atrophy. In AD, atrophy rate in the extramedial temporal lobe was even higher. Moreover, atrophy rates also accelerated in parietal, frontal, insular and occipital lobes. Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD. (orig.)

  7. A regional approach for modeling cliff retreat rate: The Makhteshim Country, Israel

    Science.gov (United States)

    Finzi, Yaron; Harlev, Noam

    2016-10-01

    Cliff retreat rate significantly affect the evolution of landforms and cliff stability. Cliff retreat studies also provide intriguing clues regarding past geomorphic conditions and environmental changes. We hereby present a model to calculate cliff retreat rate based on spatial data of cliff structure and morphology. The model is applied to numerous cliffs in the arid Makhteshim Country, Israel, and results are calibrated using published rates of two local cliffs. The calculated retreat rates confirm previous assertions that the crater cliffs are receding very slowly, but reveal that the rates vary significantly along the cliffs (1-18 cm ky- 1). Results also provide first estimates of retreat rates of other major cliffs in the region including fast retreat rates at the Sede Zin cliff (300-600 cm ky- 1). The proposed model provides a robust analysis to account for local cliff-talus morphology and yields rate estimates representative of current conditions rather than a long-term (geologic) average rate. Results presented constitute important new insights into regional geomorphic processes and on the stability of specific cliff sections within the study area.

  8. Effect of radiotherapy on the eruption rate and morphology of the odontogenic region of rat incisors.

    Science.gov (United States)

    de Araujo, Amanda Maria Medeiros; Gomes, Carolina Cintra; de Almeida, Solange Maria; Klamt, Carla Beatriz; Novaes, Pedro Duarte

    2014-11-01

    The goal in this study was to evaluate the results of doses of 5 and 15 Gy of radiation in odontogenic region of the rats inferior mandibular-incisors by a histological analysis and the rate of eruptions. Animals were divided into three groups: control, radiotherapy 5 Gy and radiotherapy 15 Gy. In which tooth-eruption-rate was measured every two days. Animals in Group 5 Gy presented values similar to those of the control group. Animals in Group 15 Gy presented reduction in tooth-eruption-rate as of the sixth day of the experiment, vast disorganization of odontoblasts and ameloblasts, apparent reduction in cell population in the follicle region and alterations in cervical loop formation of the dental organ. It was concluded that there was a difference between the researched doses, and histological alteration at 15 Gy lead to statistical reduction in tooth-eruption-rate. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. 76 FR 59682 - Desert Southwest Customer Service Region-Western Area Lower Colorado Balancing Authority-Rate...

    Science.gov (United States)

    2011-09-27

    ... Area Power Administration Desert Southwest Customer Service Region--Western Area Lower Colorado... the Western Area Power Administration's (Western) Desert Southwest Customer Service Region (DSWR... Murray, Rates Manager, Desert Southwest Customer Service Region, Western Area Power Administration, P.O...

  10. Chlorhexidine Gluconate Dressings Reduce Bacterial Colonization Rates in Epidural and Peripheral Regional Catheters

    Directory of Open Access Journals (Sweden)

    Klaus Kerwat

    2015-01-01

    Full Text Available Introduction. Bacterial colonization of catheter tips is common in regional anesthesia and is a suspected risk factor for infectious complications. This is the first study evaluating the effect of CHG-impregnated dressings on bacterial colonization of regional anesthesia catheters in a routine clinical setting. Methods. In this prospective study, regional anesthesia catheter infection rates were examined in two groups of patients with epidural and peripheral regional catheters. In the first group, regional anesthesia was dressed with a conventional draping. The second group of patients underwent catheter dressing using a CHG-impregnated draping. Removed catheters and the insertion sites were both screened for bacterial colonization. Results. A total of 337 catheters from 308 patients were analysed. There was no significant reduction of local infections in either epidural or peripheral regional anesthesia catheters in both CHG and conventional groups. In the conventional group, 21% of the catheter tips and 41% of the insertion sites showed positive culture results. In the CHG-group, however, only 3% of the catheter tips and 8% of the insertion sites were colonised. Conclusion. CHG dressings significantly reduce bacterial colonization of the tip and the insertion site of epidural and peripheral regional catheters. However, no reductions in rates of local infections were seen.

  11. Regional variations in cholecystectomy rates in Sweden: impact on complications of gallstone disease.

    Science.gov (United States)

    Noel, Rozh; Arnelo, Urban; Enochsson, Lars; Lundell, Lars; Nilsson, Magnus; Sandblom, Gabriel

    2016-01-01

    There are considerable variations in cholecystectomy rates between countries, but it remains unsettled whether high cholecystectomy rates prevent future gallstone complications by reducing the gallstone prevalence. The aims of this study were to investigate the regional differences in cholecystectomy rates and their relation to the incidence of gallstone complications. Nation-wide registry-based study of the total number of cholecystectomies in Sweden between 1998 and 2013. Data were obtained from the Swedish Inpatient Registry covering the entire population and subdivided for by the 21 different counties. Indications for the procedure were prospectively collected during the years 2006-2013 in the National Registry for Gallstone Surgery and ERCP. The detailed demography of the total number of patients undergoing cholecystectomy and its relation to the respective indications were analysed by linear regression. The annual rates of cholecystectomy in the Swedish counties ranged from 100 to 207 per 100,000 inhabitants, with a mean of 157 (95% CI 145-169). The majority of cholecystectomies were done in females based on the indication biliary colic, with a peak incidence in younger ages. Cholecystectomies performed due to gallstone complications, pancreatitis and cholecystitis, were mainly carried out in the older age groups. No significant relationship could be demonstrated between cholecystectomy rates in the different regions and the respective incidences of gallstone complications. There are wide regional variations in cholecystectomy rates in Sweden. The present study does not give support that frequent use of cholecystectomy in uncomplicated gallstone disease prevents future gallstone complications.

  12. Neurodevelopmental Delay Diagnosis Rates Are Increased in a Region with Aerial Pesticide Application

    Directory of Open Access Journals (Sweden)

    Steven D. Hicks

    2017-05-01

    Full Text Available A number of studies have implicated pesticides in childhood developmental delay (DD and autism spectrum disorder (ASD. The influence of the route of pesticide exposure on neurodevelopmental delay is not well defined. To study this factor, we examined ASD/DD diagnoses rates in an area near our regional medical center that employs yearly aerial pyrethroid pesticide applications to combat mosquito-borne encephalitis. The aim of this study was to determine if areas with aerial pesticide exposure had higher rates of ASD/DD diagnoses. This regional study identified higher rates of ASD/DD diagnoses in an area with aerial pesticides application. Zip codes with aerial pyrethroid exposure were 37% more likely to have higher rates of ASD/DD (adjusted RR = 1.37, 95% CI = 1.06–1.78, p = 0.02. A Poisson regression model controlling for regional characteristics (poverty, pesticide use, population density, and distance to medical center, subject characteristics (race and sex, and local birth characteristics (prematurity, low birthweight, and birth rates identified a significant relationship between aerial pesticide use and ASD/DD rates. The relationship between pesticide application and human neurodevelopment deserves additional study to develop safe and effective methods of mosquito prevention, particularly as communities develop plans for Zika virus control.

  13. Achieving high capacity and rate capability in layered lithium transition metal oxide cathodes for lithium-ion batteries

    Science.gov (United States)

    Ahn, Juhyeon; Susanto, Dieky; Noh, Jae-Kyo; Ali, Ghulam; Cho, Byung Won; Chung, Kyung Yoon; Kim, Jong Hak; Oh, Si Hyoung

    2017-08-01

    In this study, we target to find a new composition for a layered mixed metal oxide, which has a high structural stability and a good electrochemical performance. Our strategy is to alter the transition metal composition focusing on the relative amounts of redox active Ni and Co to the inactive Mn, based on highly-stabilized LiNi1/3Co1/3Mn1/3O2. X-ray absorption near-edge structure and X-ray diffraction analyses show that the degree of cation disorder decreases on increasing the ratio of Ni and Co to Mn, by the presence of Ni3+, suggesting that slightly higher Ni and Co contents lead to improved structural stability. Electrochemical studies demonstrate that LiNi0.4Co0.4Mn0.2O2 cathodes exhibit considerable improvements in both the reversible capacity and the rate capabilities at a voltage range of 2.5-4.6 V. In situ XRD measurements reveal that LiNi0.4Co0.4Mn0.2O2 maintains a single-phase and undergoes lesser structural variations compared to controlled compositions during a delithiation process up to 4.6 V, while achieving a high reversible capacity over 200 mAh g-1. As a result, LiNi0.4Co0.4Mn0.2O2 experiences fewer structural degradations during electrochemical cycling, which explains the excellent long-term cycling performance.

  14. National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000

    DEFF Research Database (Denmark)

    Blencowe, Hannah; Cousens, Simon; Jassir, Fiorella Bianchi

    2016-01-01

    BACKGROUND: Previous estimates have highlighted a large global burden of stillbirths, with an absence of reliable data from regions where most stillbirths occur. The Every Newborn Action Plan (ENAP) targets national stillbirth rates (SBRs) of 12 or fewer stillbirths per 1000 births by 2030. We es...

  15. Capacity Regions and Sum-Rate Capacities of Vector Gaussian Interference Channels

    CERN Document Server

    Shang, Xiaohu; Kramer, Gerhard; Poor, H Vincent

    2009-01-01

    The capacity regions of vector, or multiple-input multiple-output, Gaussian interference channels are established for very strong interference and aligned strong interference. Furthermore, the sum-rate capacities are established for Z interference, noisy interference, and mixed (aligned weak/intermediate and aligned strong) interference. These results generalize known results for scalar Gaussian interference channels.

  16. Specific cerebellar regions are related to force amplitude and rate of force development.

    Science.gov (United States)

    Spraker, M B; Corcos, D M; Kurani, A S; Prodoehl, J; Swinnen, S P; Vaillancourt, D E

    2012-01-16

    The human cerebellum has been implicated in the control of a wide variety of motor control parameters, such as force amplitude, movement extent, and movement velocity. These parameters often covary in both movement and isometric force production tasks, so it is difficult to resolve whether specific regions of the cerebellum relate to specific parameters. In order to address this issue, the current study used two experiments and SUIT normalization to determine whether BOLD activation in the cerebellum scales with the amplitude or rate of change of isometric force production or both. In the first experiment, subjects produced isometric pinch-grip force over a range of force amplitudes without any constraints on the rate of force development. In the second experiment, subjects varied the rate of force production, but the target force amplitude remained constant. The data demonstrate that BOLD activation in separate sub-areas of cerebellar regions lobule VI and Crus I/II scales with both force amplitude and force rate. In addition, BOLD activation in cerebellar lobule V and vermis VI was specific to force amplitude, whereas BOLD activation in lobule VIIb was specific to force rate. Overall, cerebellar activity related to force amplitude was located superior and medial, whereas activity related to force rate was inferior and lateral. These findings suggest that specific circuitry in the cerebellum may be dedicated to specific motor control parameters such as force amplitude and force rate.

  17. Coated minispheres of salmon calcitonin target rat intestinal regions to achieve systemic bioavailability: Comparison between intestinal instillation and oral gavage.

    Science.gov (United States)

    Aguirre, Tanira A S; Aversa, Vincenzo; Rosa, Mónica; Guterres, Sílvia S; Pohlmann, Adriana R; Coulter, Ivan; Brayden, David J

    2016-09-28

    Achieving oral peptide delivery is an elusive challenge. Emulsion-based minispheres of salmon calcitonin (sCT) were synthesized using single multiple pill (SmPill®) technology incorporating the permeation enhancers (PEs): sodium taurodeoxycholate (NaTDC), sodium caprate (C10), or coco-glucoside (CG), or the pH acidifier, citric acid (CA). Minispheres were coated with an outer layer of Eudragit® L30 D-55 (designed for jejunal release) or Surelease®/Pectin (designed for colonic release). The process was mild and in vitro biological activity of sCT was retained upon release from minispheres stored up to 4months. In vitro release profiles suggested that sCT was released from minispheres by diffusion through coatings due to swelling of gelatin and the polymeric matrix upon contact with PBS at pH6.8. X-ray analysis confirmed that coated minispheres dissolved at the intended intestinal region of rats following oral gavage. Uncoated minispheres at a dose of ~2000I.U.sCT/kg were administered to rats by intra-jejunal (i.j.) or intra-colonic (i.c.) instillation and caused hypocalcaemia. Notable sCT absolute bioavailability (F) values were: 5.5% from minispheres containing NaTDC (i.j), 17.3% with CG (i.c.) and 18.2% with C10 (i.c.). Coated minispheres administered by oral gavage at threefold higher doses also induced hypocalcaemia. A highly competitive F value of 2.7% was obtained for orally-administered sCT-minispheres containing CG (45μmol/kg) and coated with Eudragit®. In conclusion, the SmPill® technology is a potential dosage form for several peptides when formulated with PEs and coated for regional delivery. PK data from instillations over-estimates oral bioavailability and poorly predicts rank ordering of formulations.

  18. Trends in corrected lung cancer mortality rates in Brazil and regions

    Science.gov (United States)

    Malta, Deborah Carvalho; de Abreu, Daisy Maria Xavier; de Moura, Lenildo; Lana, Gustavo C; Azevedo, Gulnar; França, Elisabeth

    2016-01-01

    ABSTRACT OBJECTIVE To describe the trend in cancer mortality rates in Brazil and regions before and after correction for underreporting of deaths and redistribution of ill-defined and nonspecific causes. METHODS The study used data of deaths from lung cancer among the population aged from 30 to 69 years, notified to the Mortality Information System between 1996 and 2011, corrected for underreporting of deaths, non-registered sex and age , and causes with ill-defined or garbage codes according to sex, age, and region. Standardized rates were calculated by age for raw and corrected data. An analysis of time trend in lung cancer mortality was carried out using the regression model with autoregressive errors. RESULTS Lung cancer in Brazil presented higher rates among men compared to women, and the South region showed the highest death risk in 1996 and 2011. Mortality showed a trend of reduction for males and increase for women. CONCLUSIONS Lung cancer in Brazil presented different distribution patterns according to sex, with higher rates among men and a reduction in the mortality trend for men and increase for women. PMID:27355467

  19. Some empirical estimates of the H2 formation rate in photon-dominated regions

    CERN Document Server

    Habart, E; Verstraete, L; Walmsley, C M; Pineau des Forêts, G

    2004-01-01

    We combine recent ISO observations of the vibrational ground state lines of H2 towards Photon-Dominated Regions (PDRs) with observations of vibrationally excited states made with ground-based telescopes in order to constrain the formation rate of H2 on grain surfaces under the physical conditions in the layers responsible for H2 emission. We use steady state PDR models in order to examine the sensitivity of different H2 line ratios to the H2 formation rate Rf. We show that the ratio of the 0-0 S(3) to the 1-0 S(1) line increases with Rf but that one requires independent estimates of the radiation field incident upon the PDR and the density in order to infer Rf from the H2 line data. We confirm the earlier result of Habart et al. (2003) that the H2 formation rate in regions of moderate excitation such as Oph W, S140 and IC 63 is a factor of 5 times larger than the standard rate inferred from UV observations of diffuse clouds. On the other hand, towards regions of higher radiation field such as the Orion Bar an...

  20. Developments of regional gross domestic product and the unemployment rate in Romania during 2000 - 2012

    Directory of Open Access Journals (Sweden)

    Schonauer (Sacală Corina

    2015-12-01

    Full Text Available Economic development of territorial units can be characterized by measuring the ability of producing goods and services and by measuring labor force in the area. The capacity of producing goods and services is measured by calculating the gross domestic product indicator. This article presents a comparative analysis of the evolution of regional GDP and the ILO unemployment rate at the level of the eight regions in Romania for a period of 13 years. The presented data come from the National Institute of Statistics of Romania.

  1. [Mortality for accident in Tuscany Region (Central Italy) in immigrants from countries at high migration rates].

    Science.gov (United States)

    Indiani, Laura; Martini, Andrea; Chellini, Elisabetta

    2014-01-01

    to examine the characteristics and mortality trends for specific type of accident in immigrants resident in Tuscany and to compare them to those observed in Italians resident in the same region. descriptive study using the data of the Regional Mortality Registry of Tuscany. 1997-2008 deaths for accidents by citizenship ("Italians" and "Immigrants" from Countries with strong migratory pressure or PFPM) in residents in Tuscany. number of deaths, proportional mortality and standardized (standard: European population) mortality 15-64 truncated rates per 100,000 for each specific accidental cause of death, by gender and population (PFPM and Italians), in 1997-2008, and confidence intervals at 95% (95%CI); trends in mortality standardized truncated rates for specific accidental cause in immigrants and Italians in 2002-2008. in the period 1997-2008, 315 deaths for accidents have been registered in immigrants. The comparison between immigrants and Italians did not reveal any significant difference in mortality for road and at work accidents. Suicides are significantly higher in Italian males (rate in Italians 9.3; 95%CI 8.7-10.0 vs. rate in PFPM 4.3; 95%CI 2.4-6.2), while homicides are higher in male immigrants (rate in Italians 0.6; IC95% 0.4-0.8 vs. rate in PFPM 3.2 95%CI 1.7-4.7). Deaths from other injuries are more frequent in Italians in both genders. Trends in mortality rates indicate a reducing gap between immigrants and Italians. in Tuscany, mortality rates for some specific accidental causes are significantly different between immigrants and Italians, nevertheless trends of the last evaluated period seem to reveal a reducing gap suggesting a progressive integration of immigrants.

  2. Regional changes over time in initial virologic response rates to combination antiretroviral therapy across Europe

    DEFF Research Database (Denmark)

    Bannister, Wendy P; Kirk, Ole; Gatell, Jose M

    2006-01-01

    BACKGROUND: Changes in virologic response to initial combination antiretroviral therapy (cART) over calendar time may indicate improvements in cART or emergence of primary resistance. Regional variations may identify differences in available antiretroviral drugs or patient management. METHODS......: Virologic response (viral load ART was analyzed in antiretroviral-naive EuroSIDA patients. Analyses were stratified by region (south, central west, north, east) or time started cART (early, 1996-1997; mid, 1998-1999; late, 2000-1904). RESULTS: Virologic...... suppression was achieved by 60% of 2102 patients: 57% south (n = 560), 61% central west (n = 466), 63% north (n = 606), 58% east (n = 470) (P = 0.091). An increase was observed over time: 52% early cART, 56% mid cART, 69% late cART (P

  3. Regional changes over time in initial virological response rates to combination antiretroviral therapy across Europe

    DEFF Research Database (Denmark)

    Bannister, W; Kirk, O; Gatell, J

    2006-01-01

    BACKGROUND: Changes in virologic response to initial combination antiretroviral therapy (cART) over calendar time may indicate improvements in cART or emergence of primary resistance. Regional variations may identify differences in available antiretroviral drugs or patient management. METHODS......: Virologic response (viral load ART was analyzed in antiretroviral-naive EuroSIDA patients. Analyses were stratified by region (south, central west, north, east) or time started cART (early, 1996-1997; mid, 1998-1999; late, 2000-1904). RESULTS: Virologic...... suppression was achieved by 60% of 2102 patients: 57% south (n = 560), 61% central west (n = 466), 63% north (n = 606), 58% east (n = 470) (P = 0.091). An increase was observed over time: 52% early cART, 56% mid cART, 69% late cART (P

  4. The heating rate in the tropical tropopause region; Die Erwaermungsrate in der tropischen Tropopausenregion

    Energy Technology Data Exchange (ETDEWEB)

    Hamann, Ulrich

    2010-07-01

    The major part of the movement of air masses from the troposphere to the stratosphere takes place in the tropics. The conveyed air mass is transported with the Brewer-Dobson circulation poleward and therefore influences the global stratospheric composition. An important cause variable for the transport of air through the tropical tropopause layer (TTL) is the radiative heating, which is investigated in this work. The influence of trace gases, temperature, and cloudiness on the heating rate is quantified, especially the effect of the overlap of several cloud layers is discussed. The heating rate in the tropics is simulated for one year. Regional differences of the heating rate profile appear between convective and stably stratified regions. By means of trace gas concentrations, temperature, and heating rates it is determined that an enhanced transport of air through the TTL took place between January and April 2007. The comparison with previous works shows that accurate input data sets of trace gases, temperature, and cloudiness and exact methods for the simulation of the radiative transfer are indispensable for modeling of the heating rate with the required accuracy. (orig.)

  5. Аrctic tourism: the rating of regions, the оpportunities and threats

    Directory of Open Access Journals (Sweden)

    Yury F. Lukin

    2016-06-01

    Full Text Available Arctic and northern tourism as operational definitions are used in scientific publications more infrequently and irregularly. In practice, the tourism has become an inalienable sector of the economy; it has a multiplying effect for the development of social services, infrastructure and other sectors. The first National Tourist Rating of the 85 subjects of the Russian Federation (2015, the first rating of tourist attractiveness of the regions of the Russian Arctic contributes to the analyzes of the opportunities and threats to tourism.

  6. Regional Gradients in Institutional Cesarean Delivery Rates: Evidence from Five Countries in Asia.

    Science.gov (United States)

    Sepehri, Ardeshir; Guliani, Harminder

    2017-03-01

    Although the influence of the type of institutional setting on the risk of cesarean birth is well documented, less is known about the regional variations in institution-specific cesarean rates within countries. Our purpose was to examine regional variations in cesarean rates across public and private facilities in five Asian countries with a sizeable private sector: Bangladesh, India, Indonesia, Pakistan, and the Philippines. Demographic Health Survey data and a hierarchical model were used to assess regional variations in the mode of delivery while controlling for a wide range of socioeconomic, demographic, and maternal risk factors. The risk of cesarean birth was greater in a private facility than in a government hospital by 36-48 percent in India and Indonesia and by 130 percent in Bangladesh. Regional gradients in cesarean birth were found to be steeper for deliveries in private facilities than in government hospitals in India, Indonesia, and the Philippines. The residents of India's high-use states were 55 percent more likely to undergo a cesarean delivery in a government hospital and 83 percent more likely in a private facility than their counterparts in the medium-use states. Similarly, compared to the residents of the Philippines's medium-use provinces, giving birth in a government facility increased the likelihood of a cesarean delivery by 84 percent and by 173 percent in a private facility. Large regional variations in cesarean rates suggest the need for more informed clinical decision making with respect to the selection of cases for cesarean delivery and the establishment of well-developed guidelines and standards at the provincial or state levels. © 2016 Wiley Periodicals, Inc.

  7. [Comparative rate of regional metastasis of high differentiated carcinoma of the thyroid gland].

    Science.gov (United States)

    Konstantinova, N N; Evmenova, T D; Drozdova, D É

    2014-01-01

    The rate of metastasis of high differentiated carcinoma of the thyroid glands to the neck lymph nodes was studied in people of Kemerovo Region. The metastatic lesions of pretracheal lymph nodes (VI group) were detected in 49.5% patients with papillary carcinoma and 21.0% of patients with follicular cancer. Metastases in jungular lymph nodes were revealed in 37.3% patients with papillary carcinoma. It was noted that an extension of metastatic lesions of regional lymph nodes was observed in the case of primary tumour foci spread beyond borders of the capsula glandularis in patients with papillary carcinoma. There wasn't such a relation in a case of follicular cancer. Metastases in regional lymph nodes were detected more often (67.6%) in the case of papillary carcinoma in uncontaminated zone of the thyroid gland compared with other thyroid pathology (31.7%).

  8. Governance and Regional Variation of Homicide Rates: Evidence From Cross-National Data.

    Science.gov (United States)

    Cao, Liqun; Zhang, Yan

    2017-01-01

    Criminological theories of cross-national studies of homicide have underestimated the effects of quality governance of liberal democracy and region. Data sets from several sources are combined and a comprehensive model of homicide is proposed. Results of the spatial regression model, which controls for the effect of spatial autocorrelation, show that quality governance, human development, economic inequality, and ethnic heterogeneity are statistically significant in predicting homicide. In addition, regions of Latin America and non-Muslim Sub-Saharan Africa have significantly higher rates of homicides ceteris paribus while the effects of East Asian countries and Islamic societies are not statistically significant. These findings are consistent with the expectation of the new modernization and regional theories. © The Author(s) 2015.

  9. ANALYSIS OF INTERDEPENDENCE BETWEEN ARRIVALS OF TOURISTS IN BOARDING HOUSES, ACCOMMODATION CAPACITY AND RELATIVE POVERTY RATE TO REGIONAL DEVELOPMENT LEVEL

    Directory of Open Access Journals (Sweden)

    GHIZDEANU ION

    2016-02-01

    Full Text Available Regardless of the activity area, the link between the firm, sustainability and the necessary means to achieve that desideratum, is real and accepted in the context in which scientists, investors, entrepreneurs, state and citizens are becoming more and more aware of the devastating impact of the chaotic activities aimed at making a profit at any cost. Being aware of the importance of the correlation between ecotourism and sustainability, after a preliminary conceptualization of the means to promote green tourism business, and some elements of ecological marketing an analysis has been attempted via the linear regression model of interdependence between arrivals of tourists in the rural boarding houses, accommodation capacity and the relative poverty rate at the level of development region in Romania. In this sense, the data provided by the National Institute of Statistics have been used.

  10. Cancer incidence rates in the Kurdistan region/Iraq from 2007-2009.

    Science.gov (United States)

    Othman, Ramadhan T; Abdulljabar, Rezvan; Saeed, Abdullah; Kittani, Sarwar Sadiq; Sulaiman, Hushyar M; Mohammed, Sami A; Rashid, Rekawt M; Hussein, Nawfal R

    2011-01-01

    Cancer is a disease of gradual increase in incidence overall the world. Kurdistan Region in Iraq has been exposed to several carcinogenic hazards. There are few reports about the increased risk of cancer in different cities in Iraq. These reports did not cover Kurdistan region. The aim of this paper was to study cancer incidence and to identify possible risks of cancer in this region. Cancer registries from 9 hospitals in three cities of Kurdistan were used as a source of data. Information on these cases was subjected to careful verification regarding repetition, place of residence and other possible errors. Overall registered cases in 2007, 2008 and 2009 were 1444, 2081, 2356 respectively. 49% of registered cases were males and 51% were female. The Age Standardized Rate of cancer was 89.83/100 000 among male and 83.93/100 000 among female. The results showed major variation in incidence rates of different types of cancer in the three governorates of Kurdistan. Furthermore, there was evidence of increased risks of cancer in Kurdistan Region in Iraq. Hematological malignancies were the most common cancer among male (21.13% of all cancer in males) and second most common in female (18.8% of all cancer in female), only exceeded by breast cancer. To reach sound conclusions about extent and determinants of cancer in Kurdistan, enormous multi-spectrum efforts are now needed.

  11. Effects of a Gluten-Free Diet on Rate of Achievement in Autistic Children in an Applied Behavioral Analysis Program.

    Science.gov (United States)

    Gemmell, Melissa; Chambliss, Catherine

    This study used both between-subjects and within-subjects analyses to examine the effects of a gluten-free diet on the academic achievement of autistic children. The between-subjects analysis included data from eight autistic children (ages 5 to 7) with four on a gluten-free diet and four serving as controls. The number of attempts needed before…

  12. Higher order scrambled digital nets achieve the optimal rate of the root mean square error for smooth integrands

    CERN Document Server

    Dick, Josef

    2010-01-01

    We study numerical approximations of integrals $\\int_{[0,1]^s} f(\\bsx) \\,\\mathrm{d} \\bsx$ by averaging the function at some sampling points. Monte Carlo (MC) sampling yields a convergence of the root mean square error (RMSE) of order $N^{-1/2}$ (where $N$ is the number of samples). Quasi-Monte Carlo (QMC) sampling on the other hand achieves a convergence of order $N^{-1+\\varepsilon}$, for any $\\varepsilon >0$. Randomized QMC (RQMC), a combination of MC and QMC, achieves a RMSE of order $N^{-3/2+\\varepsilon}$. A combination of RQMC with local antithetic sampling achieves a convergence of the RMSE of order $N^{-3/2-1/s+\\varepsilon}$ (where $s \\ge 1$ is the dimension). QMC, RQMC and RQMC with local antithetic sampling require that the integrand has some smoothness (for instance, bounded variation). Stronger smoothness assumptions on the integrand do not improve the convergence of the above algorithms further. This paper introduces a new RQMC algorithm, for which we prove that it achieves a convergence of the RMS...

  13. Glomerular filtration rate in examined population of Bosnian Posavina - region of Balkan Endemic Nephropathy.

    Science.gov (United States)

    Alecković, Mirna; Mesić, Enisa; Trnacević, Senaid; Stipancić, Zelimir; Hamidović, Damir; Hasanović, Evlijana

    2010-04-01

    Balkan endemic nephropathy (BEN) is chronic tubulointersticial nephritis of unknown aetiology characterized by an insidious onset and gradual progression to end stage renal disease (ESRD). Endemic regions of Bosnia and Herzegovina are Posavina and Semberija, sited at basin of Sava River. In BEN, just like in other chronic renal diseases (CKD), glomerular filtration rate (GFR), is assumed a marker of overall renal function. The aim of this study was to compare GFR in examinees of endemic and non-endemic region for BEN, and between examinees with and without risk factors for BEN within endemic region. Study included 603 inhabitants of Bosnian Posavina, out of whom 386 (65%) from endemic (Domaljevac) and 217 (36%) from non-endemic (Svilaj) village, and it was performed in two phases. The first phase encompassed obtaining anamnestic data (demographic, personal and family history), measurement of arterial blood pressure, and urine dipstick testing (specific gravity, pH, proteins, leukocytes, glucose, ketones, and microalbuminuria). In the second phase, besides repeated urine dipstick test, laboratory blood testing and abdominal ultrasound, with special attention to urinary tract, was also performed. We have compared GFR between examinees of endemic and non-endemic regions for BEN, and between examinees with and without family burden for BEN within endemic region, using MDRD formula for calculating GFR, with cut-off value (5th percentile) based on result of studies performed in European Caucasians in screening for CKD and for establishing stages of CKD in BEN. Medical was used for statistical testing. Out of total number of examined inhabitants (603), 145 examinees were included in the second phase. After exclusion of 17 diabetic patients, 94 (73%) examinees from endemic and 34 (27%) examinees from non-endemic region remained. In the endemic region there were 46 (49%) examinees with and 48 (51%) without family burden for BEN. Overall GFR in examined groups was within

  14. The Influence of Photolysis Rate Constants in Ozone Production for the Paso del Norte Region

    Science.gov (United States)

    Becerra, Fernando; Fitzgerald, Rosa

    2012-03-01

    In this research work we are focusing on understanding the relationship between photolysis rates and the photochemical ozone changes observed in the Paso del Norte region. The city of El Paso, Texas together with Ciudad Juarez, Mexico, forms the largest contiguous bi-national metropolitan area. This region suffers year-round ozone pollution events, and a better understanding is needed to mitigate them. Previous studies have found that ambient ozone concentrations tend to be higher on weekends rather than on weekdays, this phenomenon being referred to, as the ``weekend effect.'' If the ozone standard is exceeded more frequently on weekends, then this phenomenon must be considered in the design of ozone control strategies. In this work we investigate some of the most representative weekend ozone episodes at El Paso, TX, during the years 2009, 2010 and 2011 using the ozone photolysis rates. In this research the TUV radiative-transfer model is used to calculate the local photolysis rates and a UV MFRSR instrument is used to obtain experimental parameters. Seasonal variations and the weekday-weekend effect is studied. The results of this research will help to understand the underlying behavior of the photolysis rate constants when different atmospheric conditions are present.

  15. The relationship of regional hemoglobin A1c testing and amputation rate among patients with diabetes.

    Science.gov (United States)

    Newhall, Karina A; Bekelis, Kimon; Suckow, Bjoern D; Gottlieb, Daniel J; Farber, Adrienne E; Goodney, Philip P; Skinner, Jonathan S

    2017-04-01

    Objective The risk of leg amputation among patients with diabetes has declined over the past decade, while use of preventative measures-such as hemoglobin A1c monitoring-has increased. However, the relationship between hemoglobin A1c testing and amputation risk remains unclear. Methods We examined annual rates of hemoglobin A1c testing and major leg amputation among Medicare patients with diabetes from 2003 to 2012 across 306 hospital referral regions. We created linear regression models to study associations between hemoglobin A1c testing and lower extremity amputation. Results From 2003 to 2012, the proportion of patients who received hemoglobin A1c testing increased 10% (74% to 84%), while their rate of lower extremity amputation decreased 50% (430 to 232/100,000 beneficiaries). Regional hemoglobin A1c testing weakly correlated with crude amputation rate in both years (2003 R = -0.20, 2012 R = -0.21), and further weakened with adjustment for age, sex, and disability status (2003 R = -0.11, 2012 R = -0.17). In a multivariable model of 2012 amputation rates, hemoglobin A1c testing was not a significant predictor. Conclusion Lower extremity amputation among patients with diabetes nearly halved over the past decade but only weakly correlated with hemoglobin A1c testing throughout the study period. Better metrics are needed to understand the relationship between preventative care and amputation.

  16. Evaluating Alzheimer’s Disease Progression Using Rate of Regional Hippocampal Atrophy

    Science.gov (United States)

    Frankó, Edit; Joly, Olivier

    2013-01-01

    Alzheimer’s disease (AD) is characterized by neurofibrillary tangle and neuropil thread deposition, which ultimately results in neuronal loss. A large number of magnetic resonance imaging studies have reported a smaller hippocampus in AD patients as compared to healthy elderlies. Even though this difference is often interpreted as atrophy, it is only an indirect measurement. A more direct way of measuring the atrophy is to use repeated MRIs within the same individual. Even though several groups have used this appropriate approach, the pattern of hippocampal atrophy still remains unclear and difficult to relate to underlying pathophysiology. Here, in this longitudinal study, we aimed to map hippocampal atrophy rates in patients with AD, mild cognitive impairment (MCI) and elderly controls. Data consisted of two MRI scans for each subject. The symmetric deformation field between the first and the second MRI was computed and mapped onto the three-dimensional hippocampal surface. The pattern of atrophy rate was similar in all three groups, but the rate was significantly higher in patients with AD than in control subjects. We also found higher atrophy rates in progressive MCI patients as compared to stable MCI, particularly in the antero-lateral portion of the right hippocampus. Importantly, the regions showing the highest atrophy rate correspond to those that were described to have the highest burden of tau deposition. Our results show that local hippocampal atrophy rate is a reliable biomarker of disease stage and progression and could also be considered as a method to objectively evaluate treatment effects. PMID:23951142

  17. Development of Pathways to Achieve the SE4ALL Energy Efficiency Objective: Global and Regional Potential for Energy Efficiency Improvements

    DEFF Research Database (Denmark)

    Gregg, Jay Sterling; Balyk, Olexandr; Pérez, Cristian Hernán Cabrera

    efficiency. When the SE4ALL renewable energy objective is achieved, the economically optimal solution produced by ETSAP-TIAM also includes a reduction in energy intensity: globally, the compound annual reduction in energy intensity of GDP is 1.8% when the renewable energy objective is achieved. Likewise...

  18. Impact of Clinical Factors on the Achievement of Target Blood Pressure in Hypertensive Patients from Ivanovo Region of Russia: Data of 2015.

    Science.gov (United States)

    Kiselev, A R; Posnenkova, O M; Belova, O A; Romanchuk, S V; Popova, Y V; Prokhorov, M D; Gridnev, V I

    2017-08-30

    In Russia, blood pressure (BP) control is below the optimal. The little is known about regional features and barriers to adequate BP control in Russian primary care. To evaluate the impact of clinical factors on achieving the target BP in hypertensive patients in one region of Russia. Retrospective medical data of 2015 on 11,129 patients (31.4% male) with hypertension (Htn) from Ivanovo region of Russia were examined. Achievement of target BP was assessed in all patients. We study association between BP control and clinical factors. 45.9% of studied patients with Htn had controlled BP. The frequency of achieving the target BP in subsets of hypertensive patients was 37.8% in patients with diabetes, 39.5% in patients with coronary artery disease, and 29.9% in patients with chronic heart failure. The main clinical factors associated with achieving the target BP in studied hypertensive patients were the advice on alcohol consumption, advice on smoking cessation, and advice on weight reduction. Therapy with main antihypertensive drugs (in particular, beta-blockers and thiazide diuretics) were also factors of optimal BP control in these patients. Comorbidities (chronic heart failure and cardiovascular diseases requiring the prescription of aspirin and statins) and family history of coronary artery disease were associated with inadequate BP control. A negative effect of some antihypertensive drugs (potassium sparing diuretics, ARBs, ACE-Is, and dihydropyridine CCBs) on BP control that was found out in our study requires further investigation. Other studied factors had no influence on BP control in patients with Htn from Ivanovo region. We identified regional factors of BP control in hypertensive patients from Ivanovo region of Russia. It is shown that individual medical education (in particular, medical advices) is the most important factor of optimal BP control. The intervention with antihypertensive therapy (beta-blockers and thiazide diuretics) facilitates the

  19. Parent Rated Symptoms of Inattention in Childhood Predict High School Academic Achievement Across Two Culturally and Diagnostically Diverse Samples

    Directory of Open Access Journals (Sweden)

    Astri J. Lundervold

    2017-08-01

    Full Text Available Objective: To investigate parent reports of childhood symptoms of inattention as a predictor of adolescent academic achievement, taking into account the impact of the child’s intellectual functioning, in two diagnostically and culturally diverse samples.Method: Samples: (a an all-female sample in the U.S. predominated by youth with ADHD (Berkeley Girls with ADHD Longitudinal Study [BGALS], N = 202, and (b a mixed-sex sample recruited from a Norwegian population-based sample (the Bergen Child Study [BCS], N = 93. Inattention and intellectual function were assessed via the same measures in the two samples; academic achievement scores during and beyond high school and demographic covariates were country-specific.Results: Childhood inattention predicted subsequent academic achievement in both samples, with a somewhat stronger effect in the BGALS sample, which included a large subgroup of children with ADHD. Intellectual function was another strong predictor, but the effect of early inattention remained statistically significant in both samples when intellectual function was covaried.Conclusion: The effect of early indicators of inattention on future academic success was robust across the two samples. These results support the use of remediation procedures broadly applied. Future longitudinal multicenter studies with pre-planned common inclusion criteria should be performed to increase our understanding of the importance of inattention in primary school children for concurrent and prospective functioning.

  20. Investigations on the heat transport capability of a cryogenic oscillating heat pipe and its application in achieving ultra-fast cooling rates for cell vitrification cryopreservation☆

    OpenAIRE

    Han, Xu; Ma, Hongbin; Jiao, Anjun; Critser, John K.

    2008-01-01

    Theoretically, direct vitrification of cell suspensions with relatively low concentrations (~1 M) of permeating cryoprotective agents (CPA) is suitable for cryopreservation of almost all cell types and can be accomplished by ultra-fast cooling rates that are on the order of 106–7 K/min. However, the methods and devices currently available for cell cryopreservation cannot achieve such high cooling rates. In this study, we constructed a novel cryogenic oscillating heat pipe (COHP) using liquid ...

  1. Regional Heterogeneity in the Rates of Warming from CO2 Emissions

    Science.gov (United States)

    Ricke, K.; Caldeira, K.

    2015-12-01

    While it is commonly understood that the magnitudes of global warming from anthropogenic emissions are and will be spatially heterogeneous, little work has been done exploring heterogeneity in the timing of effects from an emission of carbon dioxide (CO2). Using the results from the Coupled Model Intercomparison Project v5 (CMIP5) abrupt4xco2 experiment, we explore regional differences in the timing, as opposed to magnitude, of the warming from emissions of CO2. Our analysis reveals a surprisingly high amount of regional diversity in the pace of realization of the warming effect of a CO2 emission, with relatively accelerated warming for areas such as the eastern United States and Central Asia and a relatively long lag between emission and warming effect for Australia and Amazonia. Figure 1 shows the ratio of the ensemble median rate of warming in the first decade after a change in CO2 concentration to the rate of warming for the remainder of the first century. Because estimates of social cost of carbon implicitly assume similar timing of warming for all regions, the observed effects have important implications for climate policy.

  2. Amputation rates for patients with diabetes and peripheral arterial disease: the effects of race and region

    Science.gov (United States)

    Spangler, Emily; Dzebisashvili, Nino; Goodman, David C.; Goodney, Philip

    2016-01-01

    BACKGROUND It remains unknown whether care of high-risk vascular patients with both diabetes and peripheral arterial disease is improving. We examined national trends in care of patients with both peripheral arterial disease and diabetes. METHODS A cohort of patients diagnosed with peripheral arterial disease and diabetes between 2007–2011 undergoing open or endovascular diagnostic or revascularization procedures was analyzed using Medicare claims data. Main outcome measure was amputation-free survival measured from time of initial revascularization procedure to 24 months, stratified by race and hospital referral region (HRR). RESULTS 2.3 per 1,000 patients underwent a major amputation from 2007–2011, with the higher rate among black patients (5.5 per 1,000 versus 1.9 per 1,000, pamputation rates in black patients (2.1 to 16.1 per 1,000). Overall, amputation-free survival was approximately 74.6% at 2 years, 68.4% among black patients and 75.4% among non-black patients, with the disparity between the 2 groups increasing over time. CONCLUSIONS Prevalence of concurrent peripheral arterial disease and diabetes is increasing, but amputation rates and amputation-free survival vary significantly by both race and hospital referral region. Prevention and care coordination effort should aim to limit racial disparities in the treatment and outcomes of these high-risk patients. PMID:26549811

  3. Experimental Comparison of Gains in Achievable Information Rates from Probabilistic Shaping and Digital Backpropagation for DP-256QAM/1024QAM WDM Systems

    DEFF Research Database (Denmark)

    Porto da Silva, Edson; Yankov, Metodi Plamenov; Da Ros, Francesco;

    2016-01-01

    Gains in achievable information rates from probabilistic shaping and digital backpropagation are compared for WDM transmission of 5 × 10 GBd DP-256QAM/1024QAM up to 1700 km of reach. The combination of both techniques its shown to provide gains of up to ∼0.5 bits/QAM symbol...

  4. Relations among Academic Enablers and Academic Achievement in Children with and without High Levels of Parent-Rated Symptoms of Inattention, Impulsivity, and Hyperactivity

    Science.gov (United States)

    Demaray, Michelle Kilpatrick; Jenkins, Lyndsay N.

    2011-01-01

    This study examined the relationships among academic enablers (i.e., engagement, interpersonal skills, motivation, study skills) and academic achievement in children with and without high levels of parent-rated symptoms of inattention, impulsivity, and hyperactivity (Symptoms of IIH Group). The study included 69 participants (29 [42%] in the IIH…

  5. Mutations of different molecular origins exhibit contrasting patterns of regional substitution rate variation.

    Directory of Open Access Journals (Sweden)

    Navin Elango

    2008-02-01

    Full Text Available Transitions at CpG dinucleotides, referred to as "CpG substitutions", are a major mutational input into vertebrate genomes and a leading cause of human genetic disease. The prevalence of CpG substitutions is due to their mutational origin, which is dependent on DNA methylation. In comparison, other single nucleotide substitutions (for example those occurring at GpC dinucleotides mainly arise from errors during DNA replication. Here we analyzed high quality BAC-based data from human, chimpanzee, and baboon to investigate regional variation of CpG substitution rates. We show that CpG substitutions occur approximately 15 times more frequently than other single nucleotide substitutions in primate genomes, and that they exhibit substantial regional variation. Patterns of CpG rate variation are consistent with differences in methylation level and susceptibility to subsequent deamination. In particular, we propose a "distance-decaying" hypothesis, positing that due to the molecular mechanism of a CpG substitution, rates are correlated with the stability of double-stranded DNA surrounding each CpG dinucleotide, and the effect of local DNA stability may decrease with distance from the CpG dinucleotide.Consistent with our "distance-decaying" hypothesis, rates of CpG substitution are strongly (negatively correlated with regional G+C content. The influence of G+C content decays as the distance from the target CpG site increases. We estimate that the influence of local G+C content extends up to 1,500 approximately 2,000 bps centered on each CpG site. We also show that the distance-decaying relationship persisted when we controlled for the effect of long-range homogeneity of nucleotide composition. GpC sites, in contrast, do not exhibit such "distance-decaying" relationship. Our results highlight an example of the distinctive properties of methylation-dependent substitutions versus substitutions mostly arising from errors during DNA replication. Furthermore

  6. Variability of adenoidectomy/tonsillectomy rates among children of the Veneto Region, Italy

    Directory of Open Access Journals (Sweden)

    Andretta Marilisa

    2009-02-01

    Full Text Available Abstract Background Despite national guidelines in 2003 aimed at limiting the recourse to tonsillectomy and/or adenoidectomy (A/T, the latter are among the most frequent pediatric surgeries performed in Italy. Aim of the study is to investigate variability of A/T rates among children of the Veneto Region, Italy. Methods All discharges of Veneto residents with Diagnosis-Related Groups 57–60 and ICD9-CM intervention codes 28.2 (tonsillectomy, 28.3 (adenotonsillectomy, 28.6 (adenoidectomy were selected in the period 2000–2006 for a descriptive analysis. A multilevel Poisson regression model was applied to estimate Incidence Rate Ratios (IRR with 95% Confidence Intervals (CI for A/T surgery among children aged 2–9 years in 2004–2006, while taking into account clustering of interventions within the 21 Local Health Units. Results Through 2000–2006, the overall number of A/T surgeries decreased (-8%; there was a decline of adenoidectomies (-20% and tonsillectomies (-8%, whereas adenotonsillectomies raised (+18%. Analyses on children aged 2–9 resulted in an overall rate of 14.4 surgeries per 1000 person-years (16.1 among males and 12.5 among females, with a wide heterogeneity across Local Health Units (range 8.1–27.6. At random intercept Poisson regression, while adjusting for sex and age, intervention rates were markedly lower among foreign than among Italian children (IRR = 0.57, CI 0.53–0.61. A/T rates in the 10–40 age group (mainly tonsillectomies computed for each Local Health Unit and introduced in the regression model accounted for 40% of the variance at Local Health Unit level of pediatric rates (mainly adenoidectomies and adenotonsillectomies. Conclusion A/T rates in the Veneto Region, especially adenoidectomies among children aged 2–9 years, remain high notwithstanding a decrease through 2000–2006. A wide heterogeneity according to nationality and Local Health Units is evident. The propensity to A/T surgery of each Local

  7. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2014-01-01

    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...

  8. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2016-01-01

    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...

  9. Anisotropy of the apparent resistivity variation rate near the epicentral region for strong earthquakes

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The apparent resistivity data of 11 stations observed in or near the epicentral regions for 6 strong earthquakes are processed by the normalized monthly rate method. The result show that in the medium-short and short-imminent terms of earthquake preparation the variation rate of apparent resistivity perpendicular (or near perpendicular) to the direction of maximum principal stress is greater than that parallel (or near parallel) to the direction. Such an-isotropic phenomenon is interpreted as follow: the predominant alignment of cracks containing conductive fluid in the maximum principal stress direction caused the anisotropy of the fluid migration during the dilatancy process in the late period of earthquake preparation and resulted in the anisotropy of true resistivity variation rate for rock (or solid) medium which induced the variation rate anisotropy of apparent resistivity on the ground. The study of this paper provides some seismic examples to show the apparent resistivity anisotropy which may be helpful to study the stress status in or near the source zone in the late period of earthquake preparation of strong events.

  10. Rating the Efficiency of Regional Health Systems and Compulsory Health Insurance

    Directory of Open Access Journals (Sweden)

    Tatyana Nikolayevna Russkikh

    2015-12-01

    Full Text Available In the face of increasing of the regional differentiation of the health systems and compulsory health insurance, the comparative analysis and efficiency assessment of their performance in the context of the subjects of the Russian Federation becomes particularly relevant. Therefore, the research is focused on the regional health systems and compulsory health insurance (CHI, and the subject matter of the study is the analysis of the system performance. In the article, the comparative analysis of the authors’ approaches to the formation of efficiency criteria of the performance of regional health systems and CHI, as well as to the development of a typology of the constituent entities of the Russian Federation based on these criteria is conducted. The authors propose a system of indicators to measure the economic, medical and social efficiency of the systems under consideration. Moreover, a set of indicators of economic efficiency forms two groups of indicators. The first group of indicators reflects the financial performance, and the second — the structural efficiency. A methodological approach to the formation of the rating for subjects of the Russian Federation according to the levels of efficiency, based on the procedures of cluster analysis and fuzzy mathematics are developed. A feature of the proposed approach to the construction of a typology of the subjects in terms of efficiency is the introduction of a reference subject with the national average performance indicators system that allows to qualitatively assess the effectiveness of regional health systems and CHI by comparing them with the «reference subject». The results of the empirical research have indicated a high differentiation of the subjects of the Russian Federation in terms of economic efficiency, have allowed to identify the subjects-outsiders. The theoretical and practical results can be used for the rational choice of priorities of the state policy in the field of the

  11. Groundwater age, mixing and flow rates in the vicinity of large open pit mines, Pilbara region, northwestern Australia

    Science.gov (United States)

    Cook, Peter; Dogramaci, Shawan; McCallum, James; Hedley, Joanne

    2016-09-01

    Determining groundwater ages from environmental tracer concentrations measured on samples obtained from open bores or long-screened intervals is fraught with difficulty because the sampled water represents a variety of ages. A multi-tracer technique (Cl, 14C, 3H, CFC-11, CFC-12, CFC-113 and SF6) was used to decipher the groundwater ages sampled from long-screened production bores in a regional aquifer around an open pit mine in the Pilbara region of northwest Australia. The changes in tracer concentrations due to continuous dewatering over 7 years (2008-2014) were examined, and the tracer methods were compared. Tracer concentrations suggest that groundwater samples are a mixture of young and old water; the former is inferred to represent localised recharge from an adjacent creek, and the latter to be diffuse recharge. An increase in 14C activity with time in wells closest to the creek suggests that dewatering of the open pit to achieve dry mining conditions has resulted in change in flow direction, so that localised recharge from the creek now forms a larger proportion of the pumped groundwater. The recharge rate prior to development, calculated from a steady-state Cl mass balance, is 6 mm/y, and is consistent with calculations based on the 14C activity. Changes in CFC-12 concentrations with time may be related to the change in water-table position relative to the depth of the well screen.

  12. Labour force participation rates at the regional and national levels of the European Union : An integrated analysis

    NARCIS (Netherlands)

    Elhorst, J. Paul; Zeilstra, Annette S.

    2007-01-01

    This study investigates the causes of variation in regional labour force participation rates in a cross-country perspective. A microeconomic framework of the tabour force participation decision is aggregated across individuals to obtain an explanatory rnodel of regional participation rates in which

  13. Note: Fully integrated active quenching circuit achieving 100 MHz count rate with custom technology single photon avalanche diodes

    Science.gov (United States)

    Acconcia, G.; Labanca, I.; Rech, I.; Gulinatti, A.; Ghioni, M.

    2017-02-01

    The minimization of Single Photon Avalanche Diodes (SPADs) dead time is a key factor to speed up photon counting and timing measurements. We present a fully integrated Active Quenching Circuit (AQC) able to provide a count rate as high as 100 MHz with custom technology SPAD detectors. The AQC can also operate the new red enhanced SPAD and provide the timing information with a timing jitter Full Width at Half Maximum (FWHM) as low as 160 ps.

  14. High-efficiency transfection and survival rates of embryonic and adult mouse neural stem cells achieved by electroporation.

    Science.gov (United States)

    Bertram, Bettina; Wiese, Stefan; von Holst, Alexander

    2012-08-15

    Cells of the central nervous system are notoriously difficult to transfect. This is not only true for neurons and glial cells but also for dividing neural stem and progenitor cells (NSCs). About ten years ago a major advance was provided by introduction of the nucleofection technology that allowed for transfection of approximately half of the exposed NSCs. However, limitations were encountered with the need for large numbers of NSCs for a single transfection and compromised survival rates with typically only one-third of the cells surviving the pulse conditions. Here, we report the establishment of a pulse protocol that targets NSCs with high efficiency and twofold higher NSC survival rates using the 4D Nucleofector device. We demonstrate that the established protocol not only provides a clear and significant improvement over existing protocols with transfection rates above 80% and two-thirds of the NSCs surviving for at least 48h, but also their unaltered differentiation along neuronal and glial lineages. This improved protocol for the transfection of sensitive mouse central nervous system derived cells will provide an important step forward for studies of gene function by overexpression or knock-down of genes in cultured NSCs.

  15. Methods for Estimating Mean Annual Rate of Earthquakes in Moderate and Low Seismicity Regions~

    Institute of Scientific and Technical Information of China (English)

    Peng Yanju; Zhang Lifang; Lv Yuejun; Xie Zhuojuan

    2012-01-01

    Two kinds of methods for determining seismic parameters are presented, that is, the potential seismic source zoning method and grid-spatially smoothing method. The Gaussian smoothing method and the modified Gaussian smoothing method are described in detail, and a comprehensive analysis of the advantages and disadvantages of these methods is made. Then, we take centrai China as the study region, and use the Gaussian smoothing method and potential seismic source zoning method to build seismic models to calculate the mean annual seismic rate. Seismic hazard is calculated using the probabilistic seismic hazard analysis method to construct the ground motion acceleration zoning maps. The differences between the maps and these models are discussed and the causes are investigated. The results show that the spatial smoothing method is suitable for estimating the seismic hazard over the moderate and low seismicity regions or the hazard caused by background seismicity; while the potential seismic source zoning method is suitable for estimating the seismic hazard in well-defined seismotectonics. Combining the spatial smoothing method and the potential seismic source zoning method with an integrated account of the seismicity and known seismotectonics is a feasible approach to estimate the seismic hazard in moderate and low seismicity regions.

  16. Quantum-to-the-Home: Achieving Gbits/s Secure Key Rates via Commercial Off-the-Shelf Telecommunication Equipment

    Directory of Open Access Journals (Sweden)

    Rameez Asif

    2017-01-01

    Full Text Available There is current significant interest in Fiber-to-the-Home (FTTH networks, that is, end-to-end optical connectivity. Currently, it may be limited due to the presence of last-mile copper wire connections. However, in near future, it is envisaged that FTTH connections will exist, and a key offering would be the possibility of optical encryption that can best be implemented using Quantum Key Distribution (QKD. However, it is very important that the QKD infrastructure is compatible with the already existing networks for a smooth transition and integration with the classical data traffic. In this paper, we report the feasibility of using off-the-shelf telecommunication components to enable high performance Continuous Variable-Quantum Key Distribution (CV-QKD systems that can yield secure key rates in the range of 100 Mbits/s under practical operating conditions. Multilevel phase modulated signals (m-PSK are evaluated in terms of secure key rates and transmission distances. The traditional receiver is discussed, aided by the phase noise cancellation based digital signal processing module for detecting the complex quantum signals. Furthermore, we have discussed the compatibility of multiplexers and demultiplexers for wavelength division multiplexed Quantum-to-the-Home (QTTH network and the impact of splitting ratio is analyzed. The results are thoroughly compared with the commercially available high-cost encryption modules.

  17. The Impact of Music Education on Academic Achievement, Attendance Rate, and Student Conduct on the 2006 Senior Class in One Southeast Virginia Public School Division

    OpenAIRE

    Waller, George Darryl

    2007-01-01

    For several decades music educators have proposed that the study of music has a significant impact on student academic achievement, attendance rates, and student conduct. In an era of higher student and teacher accountability, increasing budget cuts, the federal No Child Left Behind Act (NCLB), and stringent state standards of learning, a number of educators have argued that education in music can boost test scores, attendance, attitudes toward school, reduce discipline referrals, and increa...

  18. The Impact of Music Education on Academic Achievement, Attendance Rate, and Student Conduct on the 2006 Senior Class in One Southeast Virginia Public School Division

    OpenAIRE

    Waller, George Darryl

    2007-01-01

    For several decades music educators have proposed that the study of music has a significant impact on student academic achievement, attendance rates, and student conduct. In an era of higher student and teacher accountability, increasing budget cuts, the federal No Child Left Behind Act (NCLB), and stringent state standards of learning, a number of educators have argued that education in music can boost test scores, attendance, attitudes toward school, reduce discipline referrals, and increa...

  19. Wild-type and molten globular chorismate mutase achieve comparable catalytic rates using very different enthalpy/entropy compensations

    Institute of Scientific and Technical Information of China (English)

    HU Hao

    2014-01-01

    The origin of the catalytic power of enzymes with a meta-stable native state,e.g.molten globular state,is an unsolved challenging issue in biochemistry.To help understand the possible differences between this special class of enzymes and the typical ones,we report here computer simulations of the catalysis of both the well-folded wild-type and the molten globular mutant of chorismate mutase.Using the ab initio quantum mechanical/molecular mechanical minimum free-energy path method,we determined the height of reaction barriers that are in good agreement with experimental measurements.Enzyme-substrate interactions were analyzed in detail to identify factors contributing to catalysis.Computed angular order parameters of backbone N–H bonds and side-chain methyl groups suggested site-specific,non-uniform rigidity changes of the enzymes during catalysis.The change of conformational entropy from the ground state to the transition state revealed distinctly contrasting entropy/enthalpy compensations in the dimeric wild-type enzyme and its molten globular monomeric variant.A unique catalytic strategy was suggested for enzymes that are natively molten globules:some may possess large conformational flexibility to provide strong electrostatic interactions to stabilize the transition state of the substrate and compensate for the entropy loss in the transition state.The equilibrium conformational dynamics in the reactant state were analyzed to quantify their contributions to the structural transitions enzymes needed to reach the transition states.The results suggest that large-scale conformational dynamics make important catalytic contributions to sampling conformational regions in favor of binding the transition state of substrate.

  20. Achieving a Linear Dose Rate Response in Pulse-Mode Silicon Photodiode Scintillation Detectors Over a Wide Range of Excitations

    Science.gov (United States)

    Carroll, Lewis

    2014-02-01

    We are developing a new dose calibrator for nuclear pharmacies that can measure radioactivity in a vial or syringe without handling it directly or removing it from its transport shield “pig”. The calibrator's detector comprises twin opposing scintillating crystals coupled to Si photodiodes and current-amplifying trans-resistance amplifiers. Such a scheme is inherently linear with respect to dose rate over a wide range of radiation intensities, but accuracy at low activity levels may be impaired, beyond the effects of meager photon statistics, by baseline fluctuation and drift inevitably present in high-gain, current-mode photodiode amplifiers. The work described here is motivated by our desire to enhance accuracy at low excitations while maintaining linearity at high excitations. Thus, we are also evaluating a novel “pulse-mode” analog signal processing scheme that employs a linear threshold discriminator to virtually eliminate baseline fluctuation and drift. We will show the results of a side-by-side comparison of current-mode versus pulse-mode signal processing schemes, including perturbing factors affecting linearity and accuracy at very low and very high excitations. Bench testing over a wide range of excitations is done using a Poisson random pulse generator plus an LED light source to simulate excitations up to ˜106 detected counts per second without the need to handle and store large amounts of radioactive material.

  1. City-specific vehicle emission control strategies to achieve stringent emission reduction targets in China's Yangtze River Delta region.

    Science.gov (United States)

    Zhang, Shaojun; Wu, Ye; Zhao, Bin; Wu, Xiaomeng; Shu, Jiawei; Hao, Jiming

    2017-01-01

    The Yangtze River Delta (YRD) region is one of the most prosperous and densely populated regions in China and is facing tremendous pressure to mitigate vehicle emissions and improve air quality. Our assessment has revealed that mitigating vehicle emissions of NOx would be more difficult than reducing the emissions of other major vehicular pollutants (e.g., CO, HC and PM2.5) in the YRD region. Even in Shanghai, where the emission control implemented are more stringent than in Jiangsu and Zhejiang, we observed little to no reduction in NOx emissions from 2000 to 2010. Emission-reduction targets for HC, NOx and PM2.5 are determined using a response surface modeling tool for better air quality. We design city-specific emission control strategies for three vehicle-populated cities in the YRD region: Shanghai and Nanjing and Wuxi in Jiangsu. Our results indicate that even if stringent emission control consisting of the Euro 6/VI standards, the limitation of vehicle population and usage, and the scrappage of older vehicles is applied, Nanjing and Wuxi will not be able to meet the NOx emissions target by 2020. Therefore, additional control measures are proposed for Nanjing and Wuxi to further mitigate NOx emissions from heavy-duty diesel vehicles.

  2. Regional processes in mangrove ecosystems: Spatial scaling relationships, biomass, and turnover rates following catastrophic disturbance

    Science.gov (United States)

    Ward, G.A.; Smith, T. J.; Whelan, K.R.T.; Doyle, T.W.

    2006-01-01

    Physiological processes and local-scale structural dynamics of mangroves are relatively well studied. Regional-scale processes, however, are not as well understood. Here we provide long-term data on trends in structure and forest turnover at a large scale, following hurricane damage in mangrove ecosystems of South Florida, U.S.A. Twelve mangrove vegetation plots were monitored at periodic intervals, between October 1992 and March 2005. Mangrove forests of this region are defined by a -1.5 scaling relationship between mean stem diameter and stem density, mirroring self-thinning theory for mono-specific stands. This relationship is reflected in tree size frequency scaling exponents which, through time, have exhibited trends toward a community average that is indicative of full spatial resource utilization. These trends, together with an asymptotic standing biomass accumulation, indicate that coastal mangrove ecosystems do adhere to size-structured organizing principles as described for upland tree communities. Regenerative dynamics are different between areas inside and outside of the primary wind-path of Hurricane Andrew which occurred in 1992. Forest dynamic turnover rates, however, are steady through time. This suggests that ecological, more-so than structural factors, control forest productivity. In agreement, the relative mean rate of biomass growth exhibits an inverse relationship with the seasonal range of porewater salinities. The ecosystem average in forest scaling relationships may provide a useful investigative tool of mangrove community biomass relationships, as well as offer a robust indicator of general ecosystem health for use in mangrove forest ecosystem management and restoration. ?? Springer 2006.

  3. Structural relaxation time and cooling rate of a melt in the glass transition region

    Science.gov (United States)

    Sanditov, D. S.; Sydykov, B. S.

    2015-03-01

    The nature of the parameter involved in the Bartenev equation qτg = C relating the cooling rate of a glass-forming melt to its structural relaxation time in the glass transition region is discussed on the basis of the Volkenshtein-Ptitsyn theory using a number of known relationships. It is established that parameter C for amorphous substances with the same fragility is linearly temperature dependent. This parameter is shown to equal the narrow temperature range δ T g characterizing the liquid-glass transition region (by Nemilov); i.e., C = δ T g. It is concluded that δ T g for most glassy systems is only ˜0.7% of the glass transition temperature T g. The narrowness of temperature range δ T g is explained by the small fluctuation volume fraction f g "frozen" at the glass transition temperature. The concept of a close relationship between constant C and the structural order at T g (i.e., the characteristic of the inner state of a nonequilibrium "frozen" amorphous system) is developed.

  4. Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder

    Energy Technology Data Exchange (ETDEWEB)

    Buchsbaum, M.S.; Wu, J.; Haier, R.; Hazlett, E.; Ball, R.; Katz, M.; Sokolski, K.; Lagunas-Solar, M.; Langer, D.

    1987-06-22

    Patients with generalized anxiety disorder (n = 18) entered a 21-day, double-blind, placebo-controlled random assignment trial of clorazepate. Positron emission tomography with YF-deoxyglucose was carried out before and after treatment. Decreases in glucose metabolic rate in visual cortex and relative increases in the basal ganglia and thalamus were found. A correlation between regional changes in metabolic rate and regional benzodiazepine receptor binding density from other human autopsy studies was observed; brain regions highest in receptor density showed the greatest decrease in rate.

  5. Micrometeorological Measurements of Air-Surface Exchange Rates of PBTs in the Great Lakes Region

    Science.gov (United States)

    Tobias, D. E.; Perlinger, J. A.; Morrow, P.

    2002-12-01

    The fate of persistent bioaccumulative toxic chemicals (PBTs) in the environment is controlled by their exchange with various aquatic and terrestrial surfaces. Many of the PBTs are semivolatile and present in the atmosphere almost entirely in the vapor phase. The rate of exchange of these vapor phase chemicals can be predicted from physicochemical properties of the chemical and the surface and the meteorological conditions during the exchange. However, field studies of the uptake of the PBTs are extremely limited or nonexistent making it difficult to evaluate the modeled transfer velocities. This presentation describes a novel method to directly measure air-surface exchange rates of PBTs above aquatic and terrestrial surfaces by the micrometeorological technique known as the modified Bowen ratio approach. Simultaneous measurements of the air temperature, water vapor content, windspeed, and the chemical species concentration at two heights above the surface are required to derive the transfer velocity of the chemical. Advanced techniques that minimize the number of sample preparation steps are required to make the two concentration measurements with adequate relative accuracy. To accomplish this task, ambient air is sampled with a multicapillary column and the analytes are directly desorbed into a high-resolution gas chromatograph for quantitation. This presentation will summarize preliminary measurements made in the near-shore region of Upper Michigan's Keweenaw Peninsula on Lake Superior during the summer of 2001 and 2002.

  6. Soil carbon stocks and carbon sequestration rates in seminatural grassland in Aso region, Kumamoto, Southern Japan.

    Science.gov (United States)

    Toma, Yo; Clifton-Brown, John; Sugiyama, Shinji; Nakaboh, Makoto; Hatano, Ryusuke; Fernández, Fabián G; Ryan Stewart, J; Nishiwaki, Aya; Yamada, Toshihiko

    2013-06-01

    Global soil carbon (C) stocks account for approximately three times that found in the atmosphere. In the Aso mountain region of Southern Japan, seminatural grasslands have been maintained by annual harvests and/or burning for more than 1000 years. Quantification of soil C stocks and C sequestration rates in Aso mountain ecosystem is needed to make well-informed, land-use decisions to maximize C sinks while minimizing C emissions. Soil cores were collected from six sites within 200 km(2) (767-937 m asl.) from the surface down to the k-Ah layer established 7300 years ago by a volcanic eruption. The biological sources of the C stored in the Aso mountain ecosystem were investigated by combining C content at a number of sampling depths with age (using (14) C dating) and δ(13) C isotopic fractionation. Quantification of plant phytoliths at several depths was used to make basic reconstructions of past vegetation and was linked with C-sequestration rates. The mean total C stock of all six sites was 232 Mg C ha(-1) (28-417 Mg C ha(-1) ), which equates to a soil C sequestration rate of 32 kg C ha(-1)  yr(-1) over 7300 years. Mean soil C sequestration rates over 34, 50 and 100 years were estimated by an equation regressing soil C sequestration rate against soil C accumulation interval, which was modeled to be 618, 483 and 332 kg C ha(-1)  yr(-1) , respectively. Such data allows for a deeper understanding in how much C could be sequestered in Miscanthus grasslands at different time scales. In Aso, tribe Andropogoneae (especially Miscanthus and Schizoachyrium genera) and tribe Paniceae contributed between 64% and 100% of soil C based on δ(13) C abundance. We conclude that the seminatural, C4 -dominated grassland system serves as an important C sink, and worthy of future conservation.

  7. Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies.

    Science.gov (United States)

    Sarro, Lidia; Senjem, Matthew L; Lundt, Emily S; Przybelski, Scott A; Lesnick, Timothy G; Graff-Radford, Jonathan; Boeve, Bradley F; Lowe, Val J; Ferman, Tanis J; Knopman, David S; Comi, Giancarlo; Filippi, Massimo; Petersen, Ronald C; Jack, Clifford R; Kantarci, Kejal

    2016-10-01

    Alzheimer's disease pathology frequently coexists with Lewy body disease at autopsy in patients with probable dementia with Lewy bodies. More than half of patients with probable dementia with Lewy bodies have high amyloid-β deposition as measured with (11)C-Pittsburgh compound B binding on positron emission tomography. Biomarkers of amyloid-β deposition precede neurodegeneration on magnetic resonance imaging during the progression of Alzheimer's disease, but little is known about how amyloid-β deposition relates to longitudinal progression of atrophy in patients with probable dementia with Lewy bodies. We investigated the associations between baseline (11)C-Pittsburgh compound B binding on positron emission tomography and the longitudinal rates of grey matter atrophy in a cohort of clinically diagnosed patients with dementia with Lewy bodies (n = 20), who were consecutively recruited to the Mayo Clinic Alzheimer's Disease Research Centre. All patients underwent (11)C-Pittsburgh compound B positron emission tomography and magnetic resonance imaging examinations at baseline. Follow-up magnetic resonance imaging was performed after a mean (standard deviation) interval of 2.5 (1.1) years. Regional grey matter loss was determined on three-dimensional T1-weighted magnetic resonance imaging with the tensor-based morphometry-symmetric normalization technique. Linear regression was performed between baseline (11)C-Pittsburgh compound B standard unit value ratio and longitudinal change in regional grey matter volumes from an in-house modified atlas. We identified significant associations between greater baseline (11)C-Pittsburgh compound B standard unit value ratio and greater grey matter loss over time in the posterior cingulate gyrus, lateral and medial temporal lobe, and occipital lobe as well as caudate and putamen nuclei, after adjusting for age (P < 0.05). Greater baseline (11)C-Pittsburgh compound B standard unit value ratio was also associated with greater

  8. Trends in corrected lung cancer mortality rates in Brazil and regions.

    Science.gov (United States)

    Malta, Deborah Carvalho; Abreu, Daisy Maria Xavier de; Moura, Lenildo de; Lana, Gustavo C; Azevedo, Gulnar; França, Elisabeth

    2016-06-27

    To describe the trend in cancer mortality rates in Brazil and regions before and after correction for underreporting of deaths and redistribution of ill-defined and nonspecific causes. The study used data of deaths from lung cancer among the population aged from 30 to 69 years, notified to the Mortality Information System between 1996 and 2011, corrected for underreporting of deaths, non-registered sex and age , and causes with ill-defined or garbage codes according to sex, age, and region. Standardized rates were calculated by age for raw and corrected data. An analysis of time trend in lung cancer mortality was carried out using the regression model with autoregressive errors. Lung cancer in Brazil presented higher rates among men compared to women, and the South region showed the highest death risk in 1996 and 2011. Mortality showed a trend of reduction for males and increase for women. Lung cancer in Brazil presented different distribution patterns according to sex, with higher rates among men and a reduction in the mortality trend for men and increase for women. Descrever a tendência da mortalidade por câncer de pulmão no Brasil e regiões, antes e após as correções por sub-registro de óbitos, redistribuição de causas mal definidas e causas inespecíficas. Foram utilizados dados de óbitos por câncer de pulmão da população de 30 a 69 anos, notificados ao Sistema de Informação sobre Mortalidade, entre 1996 e 2011, corrigidos para sub-registro de óbitos, declaração de sexo e idade ignorados e causas com códigos mal definidos e inespecíficos segundo sexo, idade e região. Foram calculadas taxas padronizadas por idade para dados brutos e corrigidos. Realizou-se análise da tendência temporal da mortalidade por câncer de pulmão por meio do modelo de regressão com erros autorregressivos. O câncer de pulmão no Brasil apresentou taxas mais elevadas em homens que em mulheres e a região Sul foi a que apresentou maior risco de morte em 1996 e

  9. North hardship conditions rating in research works and regional policy (on examples of the regions related to resources

    Directory of Open Access Journals (Sweden)

    Vitaliy Nikolaevich Lazhentsev

    2012-12-01

    Full Text Available The influence of peculiar features of the North and the Arctic on formation of scope of research works and the directions of regional policy is shown. The assessment of cold (climatic discomfort, permafrost, etc., periferieness, high natural and resource potential, ethnicity is directed on the studying of traditional problems of demography, the organization of the relations between corporations and territories, the tax and budgetary providing. The problem of choice of measurement techniques of level of economic and social condition is especially allocated. The attempt to coordinate raw specialization of the northern and the arctic regions with the solution of strategic problems of their sustainable development is made.

  10. Decadal Erosion Rates Derived From An Earthquake-Induced Landslide Region, Central Taiwan

    Science.gov (United States)

    Chan, Y.; Lu, C.; Chang, K.; Chen, R.

    2010-12-01

    The island of Taiwan is resulted from the collision between the Philippine sea plate and the Eurasian plate. The subtropical climate and averaging four typhoons annually, combined with frequent earthquakes, influence much of the Taiwan region. Due to the factors above, not only the active orogeny of Taiwan causes the high uplift rate at about 4 mm/yr, but also drive amazing erosion rate of about 3-6 mm/yr. Previous study indicated approximately 1.9% of global suspended sediment is derived from the small island of Taiwan, which is only about 0.024% of Earth’s subaerial surface. Furthermore, modern erosion rates are strongly influenced by large earthquakes and typhoons, and the sediment fluxes after the Mw 7.6 Chi-Chi earthquake of Taiwan are much higher than those before the earthquake. Here we study the Chiufenerhshan landslide, which is one of the large landslides triggered by the Chi-Chi earthquake in the central Taiwan. The avalanche transported a mass of sedimentary rock about 60 m thick and 1.5 km long. Based on the high-resolution topographic data sets from LiDAR or photogrammetry at various years and rain fall data, we have reached the following conclusions: In the period of 8.5 years after the Chi-Chi earthquake, almost 4.2% of the landslide deposits were transported out of the landslide system. Comparing with the mean annual erosion rate of 3-6 mm/yr in Taiwan, the sediment brought out of Chiufenerhshan landslide area is 89.4 mm/yr, a significant amount contributed by the landslide. The mean sediment discharge from this small system is as large as 0.064% of the sediment discharge from the whole Taiwan annually; while the area is only about 0.005% of Taiwan’s subaerial surface. Thus, the landslide process has contributed much more to the surface erosion of the Taiwan mountain than other erosion processes.

  11. Some empirical estimates of the H2 formation rate in photon-dominated regions

    Science.gov (United States)

    Habart, E.; Boulanger, F.; Verstraete, L.; Walmsley, C. M.; Pineau des Forêts, G.

    2004-02-01

    We combine recent ISO observations of the vibrational ground state lines of H2 towards Photon-Dominated Regions (PDRs) with observations of vibrationally excited states made with ground-based telescopes in order to constrain the formation rate of H2 on grain surfaces under the physiconditions in the layers responsible for H2 emission. We briefly review the data available for five nearby PDRs. We use steady state PDR models in order to examine the sensitivity of different H2 line ratios to the H2 formation rate R_f. We show that the ratio of the 0-0 S(3) to the 1-0 S(1) line increases with Rf but that one requires independent estimates of the radiation field incident upon the PDR and the density in order to infer Rf from the H2 line data. We confirm earlier work by \\cite{habart2003a} on the Oph W PDR which showed that an H2 formation rate higher than the standard value of 3 × 10-17 cm3 s-1 inferred from UV observations of diffuse clouds is needed to explain the observed H2 excitation. From comparison of the ISO and ground-based data, we find that moderately excited PDRs such as Oph W, S140 and IC 63 require an H2 formation rate of about five times the standard value whereas the data for PDRs with a higher incident radiation field such as NGC 2023 and the Orion Bar can be explained with the standard value of Rf. We compare also the H21-0 S(1) line intensities with the emission in PAH features and find a rough scaling of the ratio of these quantities with the ratio of local density to radiation field. This suggests but does not prove that formation of H2 on PAHs is important in PDRs. We also consider some empirical models of the H2 formation process with the aim of explaining these results. Here we consider both formation on classical grains of size roughly 0.1 μm and on very small (˜10 Å) grains by either direct recombination from the gas phase (Eley-Rideal mechanism) or recombination of physisorbed H atoms with atoms in a chemisorbed site. We conclude that

  12. Association of neighbourhood unemployment rate with incident Type 2 diabetes mellitus in five German regions.

    Science.gov (United States)

    Müller, G; Wellmann, J; Hartwig, S; Greiser, K H; Moebus, S; Jöckel, K-H; Schipf, S; Völzke, H; Maier, W; Meisinger, C; Tamayo, T; Rathmann, W; Berger, K

    2015-08-01

    To analyse the association of neighbourhood unemployment with incident self-reported physician-diagnosed Type 2 diabetes in a population aged 45-74 years from five German regions. Study participants were linked via their addresses at baseline to particular neighbourhoods. Individual-level data from five population-based studies were pooled and combined with contextual data on neighbourhood unemployment. Type 2 diabetes was assessed according to a self-reported physician diagnosis of diabetes. We estimated proportional hazard models (Weibull distribution) in order to obtain hazard ratios and 95% CIs of Type 2 diabetes mellitus, taking into account interval-censoring and clustering. We included 7250 participants residing in 228 inner city neighbourhoods in five German regions in our analysis. The incidence rate was 12.6 per 1000 person-years (95% CI 11.4-13.8). The risk of Type 2 diabetes mellitus was higher in men [hazard ratio 1.79 (95% CI 1.47-2.18)] than in women and higher in people with a low education level [hazard ratio 1.55 (95% CI 1.18-2.02)] than in those with a high education level. Independently of individual-level characteristics, we found a higher risk of Type 2 diabetes mellitus in neighbourhoods with high levels of unemployment [quintile 5; hazard ratio 1.72 (95% CI 1.23-2.42)] than in neighbourhoods with low unemployment (quintile 1). Low education level and high neighbourhood unemployment were independently associated with an elevated risk of Type 2 diabetes mellitus. Studies examining the impact of the residential environment on Type 2 diabetes mellitus will provide knowledge that is essential for the identification of high-risk populations. © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.

  13. Evidence for gene-specific rather than transcription rate-dependent histone H3 exchange in yeast coding regions.

    Science.gov (United States)

    Gat-Viks, Irit; Vingron, Martin

    2009-02-01

    In eukaryotic organisms, histones are dynamically exchanged independently of DNA replication. Recent reports show that different coding regions differ in their amount of replication-independent histone H3 exchange. The current paradigm is that this histone exchange variability among coding regions is a consequence of transcription rate. Here we put forward the idea that this variability might be also modulated in a gene-specific manner independently of transcription rate. To that end, we study transcription rate-independent replication-independent coding region histone H3 exchange. We term such events relative exchange. Our genome-wide analysis shows conclusively that in yeast, relative exchange is a novel consistent feature of coding regions. Outside of replication, each coding region has a characteristic pattern of histone H3 exchange that is either higher or lower than what was expected by its RNAPII transcription rate alone. Histone H3 exchange in coding regions might be a way to add or remove certain histone modifications that are important for transcription elongation. Therefore, our results that gene-specific coding region histone H3 exchange is decoupled from transcription rate might hint at a new epigenetic mechanism of transcription regulation.

  14. Parasites and vectors carry no passport: how to fund cross-border and regional efforts to achieve malaria elimination

    Directory of Open Access Journals (Sweden)

    Gueye Cara

    2012-10-01

    Full Text Available Abstract Background Tremendous progress has been made in the last ten years in reducing morbidity and mortality caused by malaria, in part because of increases in global funding for malaria control and elimination. Today, many countries are striving for malaria elimination. However, a major challenge is the neglect of cross-border and regional initiatives in malaria control and elimination. This paper seeks to better understand Global Fund support for multi-country initiatives. Methods Documents and proposals were extracted and reviewed from two main sources, the Global Fund website and Aidspan.org. Documents and reports from the Global Fund Technical Review Panel, Board, and Secretariat documents such as guidelines and proposal templates were reviewed to establish the type of policies enacted and guidance provided from the Global Fund on multi-country initiatives and applications. From reviewing this information, the researchers created 29 variables according to eight dimensions to use in a review of Round 10 applications. All Round 10 multi-country applications (for HIV, malaria and tuberculosis and all malaria multi-country applications (6 from Rounds 1 – 10 were extracted from the Global Fund website. A blind review was conducted of Round 10 applications using the 29 variables as a framework, followed by a review of four of the six successful malaria multi-country grant applications from Rounds 1 – 10. Findings During Rounds 3 – 10 of the Global Fund, only 5.8% of grants submitted were for multi-country initiatives. Out of 83 multi-country proposals submitted, 25.3% were approved by the Technical Review Panel (TRP for funding, compared to 44.9% of single-country applications. The majority of approved multi-country applications were for HIV (76.2%, followed by malaria (19.0%, then tuberculosis (4.8%. TRP recommendations resulted in improvements to application forms, although guidance was generally vague. The in-depth review of Round 10

  15. Data-driven region-of-interest selection without inflating Type I error rate.

    Science.gov (United States)

    Brooks, Joseph L; Zoumpoulaki, Alexia; Bowman, Howard

    2017-01-01

    In ERP and other large multidimensional neuroscience data sets, researchers often select regions of interest (ROIs) for analysis. The method of ROI selection can critically affect the conclusions of a study by causing the researcher to miss effects in the data or to detect spurious effects. In practice, to avoid inflating Type I error rate (i.e., false positives), ROIs are often based on a priori hypotheses or independent information. However, this can be insensitive to experiment-specific variations in effect location (e.g., latency shifts) reducing power to detect effects. Data-driven ROI selection, in contrast, is nonindependent and uses the data under analysis to determine ROI positions. Therefore, it has potential to select ROIs based on experiment-specific information and increase power for detecting effects. However, data-driven methods have been criticized because they can substantially inflate Type I error rate. Here, we demonstrate, using simulations of simple ERP experiments, that data-driven ROI selection can indeed be more powerful than a priori hypotheses or independent information. Furthermore, we show that data-driven ROI selection using the aggregate grand average from trials (AGAT), despite being based on the data at hand, can be safely used for ROI selection under many circumstances. However, when there is a noise difference between conditions, using the AGAT can inflate Type I error and should be avoided. We identify critical assumptions for use of the AGAT and provide a basis for researchers to use, and reviewers to assess, data-driven methods of ROI localization in ERP and other studies.

  16. Assessing costs and benefits of measures to achieve Good Environmental Status in European regional seas: Challenges, opportunities and lessons learnt

    Directory of Open Access Journals (Sweden)

    Tobias Börger

    2016-10-01

    Full Text Available The EU Marine Strategy Framework Directive (MSFD requires Member States to assess the costs and benefits of Programmes of Measures (PoMs put in place to ensure that European marine waters achieve Good Environmental Status by 2020. An interdisciplinary approach is needed to carry out such an assessment whereby economic analysis is used to evaluate the outputs from ecological analysis that determines the expected effects of such management measures. This paper applies and tests an existing six-step approach to assess costs and benefits of management measures with potential to support the overall goal of the MSFD and discusses a range of ecological and economic analytical tools applicable to this task. Environmental cost-benefit analyses are considered for selected PoMs in three European case studies: Baltic Sea (Finland, East Coast Marine Plan area (UK and the Bay of Biscay (Spain. These contrasting case studies are used to investigate the application of environmental cost-benefit analysis including the challenges, opportunities and lessons learnt from using this approach. This paper demonstrates that there are opportunities in applying the six-step environmental cost-benefit analysis framework presented to assess the impact of PoMs. However, given demonstrated limitations of knowledge and data availability, application of other economic techniques should also be considered (although not applied here to complement the more formal environmental cost-benefit analysis approach.

  17. Performance-based tests versus behavioral ratings in the assessment of executive functioning in preschoolers: associations with ADHD symptoms and reading achievement.

    Directory of Open Access Journals (Sweden)

    Ana eMiranda

    2015-04-01

    Full Text Available The early assessment of the executive processes using ecologically valid instruments is essential for identifying deficits and planning actions to deal with possible adverse consequences. The present study has two different objectives. The first objective is to analyze the relationship between preschoolers’ performance on tests of Working Memory and Inhibition and parents’ and teachers’ ratings of these executive functions (EF using the Behavior Rating Inventory of Executive Function (BRIEF. The second objective consists of studying the predictive value of the different EF measures (performance-based test and rating scales on Inattention and Hyperactivity/Impulsivity behaviors and on indicators of word reading performance. The participants in the study were 209 children in the last year of preschool, their teachers and their families. Performance-based tests of Working Memory and Inhibition were administered, as well as word reading measures (accuracy and speed. The parents and teachers filled out rating scales of the EF and typical behaviors of ADHD symptomatology. Moderate correlation values were found between the different EF assessments procedures, although the results varied depending on the different domains. Metacognition index from the BRIEF presented stronger correlations with verbal working memory tests than with inhibition tests. Both the rating scales and the performance-based tests were significant predictors of Inattention and Hyperactivity/Impulsivity behaviors and the reading achievement measures. However, the BRIEF explained a greater percentage of variance in the case of the ADHD symptomatology, while the performance-based tests explained reading achievement to a greater degree. The implications of the findings for research and clinical practice are discussed.

  18. The Distribution of Fault Slip Rates and Oblique Slip Patterns in the Greater Los Angeles, CA Region

    Science.gov (United States)

    Harper, H.; Marshall, S. T.

    2014-12-01

    The Los Angeles basin is host to a complex network of active strike-slip, reverse, and oblique slip faults. Because of the large metropolitan region occupying the basin, even moderately large earthquakes (M6+) pose a significant natural hazard. Since geologic estimates have not fully characterized the distribution of active fault slip rates in the region, we use a mechanical model driven by geodetically-measured shortening rates to calculate the full three-dimensional fault slip rate distributions in the region. The modeled nonplanar fault geometries are relatively well-constrained, and use data from the SCEC community fault model. Area-weighted average fault slip rates predicted by the model match previously measured geologic slip rates in most cases; however, some geologic measurements were made in locations where the slip rate is non-characteristic of the fault (e.g. near a fault tip) and the geologic slip rate estimate disagrees with the model-predicted average slip rate. The largest discrepancy between the model predictions and geologic estimates occurs on the Sierra Madre fault, which has a model-predicted slip rate approximately 2 mm/yr greater than the geologic estimates. An advantage of the model is that it can predict the full three-dimensional mechanically compatible slip distribution along all modeled faults. The fault surface slip distribution maps show complex oblique slip patterns that arise due to the nonplanar geometries and mechanical interactions between intersecting and neighboring faults. For example, the Hollywood fault exhibits a net slip of 0.7 mm/yr at depth which increases to 1.6 mm/yr where it is intersected by the Santa Monica fault in the near-surface. Model results suggest that nearly all faults in the region have an oblique component of slip at depth, so slip rate estimates of only dip or strike-slip may underestimate the total net slip rates and seismic hazards in the region.

  19. Investigating the variations in survival rates for very preterm infants in 10 European regions: the MOSAIC birth cohort.

    NARCIS (Netherlands)

    Draper, E.S.; Zeitlin, J.; Fenton, A.C.; Weber, T.; Gerrits, J.; Martens, G.; Misselwitz, B.; Breart, G.

    2009-01-01

    OBJECTIVE: To investigate the variation in the survival rate and the mortality rates for very preterm infants across Europe. DESIGN: A prospective birth cohort of very preterm infants for 10 geographically defined European regions during 2003, followed to discharge home from hospital. PARTICIPANTS:

  20. GENERATION OF RATES FOR ELECTRIC POWER IN REGIONAL POWER SUPPLY SYSTEMS OF RUSSIA: PROBLEMS OF CHOICE REGARDING AN OPTIMUM MODEL OF RATE-MAKING

    Directory of Open Access Journals (Sweden)

    O. I. Botkin

    2010-03-01

    Full Text Available At present contradictions are being intensified and difficulties arise due to insufficiently profound scientific study of the major issues concerned with economic development of Russia. First of all, this is referred to the issues of conceptual and methodological approaches to formation of economic relations in regional power systems in order to stabilize the parameters of the energy market, to reduce risks, to increase efficiency and competitive ability of power-producing companies in the context of the transformational economy. The authors note the fact that a challenging situation has occurred in the regional power systems of Russia in terms of generation of optimal electricity rates. A number of possible solutions to the problem of electric energy loss, optimization of fuel and energy balance throughout the processing line «producers-transmitters-energy consumers» and building up a system of rate-making in the regional energy sector on this basis has been offered.

  1. Achieving a balance between small singlet-triplet energy splitting and high fluorescence radiative rate in a quinoxaline-based orange-red thermally activated delayed fluorescence emitter.

    Science.gov (United States)

    Yu, Ling; Wu, Zhongbin; Xie, Guohua; Zhong, Cheng; Zhu, Zece; Cong, Hengjiang; Ma, Dongge; Yang, Chuluo

    2016-09-21

    A new orange-red thermally activated delayed fluorescence (TADF) emitter is designed and synthesized by incorporating a fluorine-substituted quinoxaline as an electron-acceptor and a phenoxazine as an electron-donor. The rational molecular design enables small singlet-triplet energy splitting (ΔEST) and high fluorescence radiative rate (k) for long-wavelength TADF emitters. The organic light emitting diodes (OLEDs) employing the new TADF emitter achieve maximum external quantum efficiencies (EQEs) of 13.9% and 9.0% for the vacuum- and solution-processed OLEDs, respectively.

  2. AN ANTHOLOGY OF THE DISTINGUISHED ACHIEVEMENTS IN SCIENCE AND TECHNIQUE. PART 26: THREE PORTRAITS OF WORLDWIDE KNOWN MATHEMATICIANS OF KHARKOV REGION

    Directory of Open Access Journals (Sweden)

    M. I. Baranov

    2015-06-01

    Full Text Available Purpose. Short description basic confessedly in the world of scientific achievements and vital fascinations of three prominent mathematicians of modern Kharkov region − Academicians of Pogorelov A.V., Marchenko V.A. and Sadovnichiy V.A. Methodology. Scientific methods of receipt, treatment and systematization of mathematical knowledges. Methods of historical investigations of development in human society of different sections of modern mathematics. Results. Short information is resulted about basic fundamental scientific achievements in the period of 20-21 centuries of the mentioned worldwide known domestic scientists-mathematicians in area of geometry, mathematical physics, theory of partial differential equations, operators, numerical mathematics, mathematical building of complicated processes and mathematical methods of treatment of information. These achievements are considered as a background of past and modern development of mathematical science state in Kharkov. Originality. For the first time in the form of a short scientifically-historical essay by a scientist-electrophysicist using accessible for the wide circle of readers language is present important for a world association scientific achievements in the complicated area of row of modern sections of mathematics, being in basis of practically all of the sciences known us. Practical value. Scientific popularization of modern topical knowledges of humanity in the area of special sections of mathematics, opening of role of personality in development of mathematical science and expansion for the large number of people of the scientific mathematical range of interests.

  3. Decreased Sperm Motility Retarded ICSI Fertilization Rate in Severe Oligozoospermia but Good-Quality Embryo Transfer Had Achieved the Prospective Clinical Outcomes

    Science.gov (United States)

    Zheng, Jufeng; Lu, Yongning; Qu, Xianqin; Wang, Peng; Zhao, Luiwen; Gao, Minzhi; Shi, Huijuan; Jin, Xingliang

    2016-01-01

    . Overall rates in all groups were 41.26% clinical pregnancy, 25.74% implantation and 36.32% live birth, which gave live birth to 252 girls and 252 boys. Conclusions The reduction of motile spermatozoa in severe oligozoospermia decreased the rates of fertilization and good-quality embryo. Obtaining and transfer of good-quality embryos was the good prognostic to achieve prospective clinical outcomes regardless of the severity of oligozoospermia. PMID:27661081

  4. Regional Contrasts of the Warming Rate over Land Significantly Depend on the Calculation Methods of Mean Air Temperature

    Science.gov (United States)

    Wang, Kaicun; Zhou, Chunlüe

    2016-04-01

    Global analyses of surface mean air temperature (Tm) are key datasets for climate change studies and provide fundamental evidences for global warming. However, the causes of regional contrasts in the warming rate revealed by such datasets, i.e., enhanced warming rates over the northern high latitudes and the "warming hole" over the central U.S., are still under debate. Here we show these regional contrasts depends on the calculation methods of Tm. Existing global analyses calculated Tm from daily minimum and maximum temperatures (T2). We found that T2 has a significant standard deviation error of 0.23 °C/decade in depicting the regional warming rate from 2000 to 2013 but can be reduced by two-thirds using Tm calculated from observations at four specific times (T4), which samples diurnal cycle of land surface air temperature more often. From 1973 to 1997, compared with T4, T2 significantly underestimated the warming rate over the central U.S. and overestimated the warming rate over the northern high latitudes. The ratio of the warming rate over China to that over the U.S. reduces from 2.3 by T2 to 1.4 by T4. This study shows that the studies of regional warming can be substantially improved by T4 instead of T2.

  5. Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry

    Energy Technology Data Exchange (ETDEWEB)

    Davies, R.R.; Williams, Guy B. [University of Cambridge, Department of Clinical Neurosciences, Cambridge (United Kingdom); Scahill, Victoria L.; Graham, Kim S. [Cardiff University, MRC Cognition and Brain Sciences Unit, Cambridge and Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff (United Kingdom); Graham, Andrew [University of Cambridge, Department of Clinical Neurosciences, Cambridge (United Kingdom); Cardiff University, MRC Cognition and Brain Sciences Unit, Cambridge and Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff (United Kingdom); Hodges, John R. [University of Cambridge, Department of Clinical Neurosciences, Cambridge (United Kingdom); Cardiff University, MRC Cognition and Brain Sciences Unit, Cambridge and Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff (United Kingdom); Prince of Wales Medical Research Institute, Cognitive Neurology, Sydney, NSW (Australia)

    2009-08-15

    We aimed to devise a rating method for key frontal and temporal brain regions validated against quantitative volumetric methods and applicable to a range of dementia syndromes. Four standardised coronal MR images from 36 subjects encompassing controls and cases with Alzheimer's disease (AD) and frontotemporal dementia (FTD) were used. After initial pilot studies, 15 regions produced good intra- and inter-rater reliability. We then validated the ratings against manual volumetry and voxel-based morphometry (VBM) and compared ratings across the subject groups. Validation against both manual volumetry (for both frontal and temporal lobes), and against whole brain VBM, showed good correlation with visual ratings for the majority of the brain regions. Comparison of rating scores across disease groups showed involvement of the anterior fusiform gyrus, anterior hippocampus and temporal pole in semantic dementia, while anterior cingulate and orbitofrontal regions were involved in behavioural variant FTD. This simple visual rating can be used as an alternative to highly technical methods of quantification, and may be superior when dealing with single cases or small groups. (orig.)

  6. Universal salt iodization in the Central and Eastern Europe, Commonwealth of Independent States (CEE/CIS) Region during the decade 2000-09: experiences, achievements, and lessons learned.

    Science.gov (United States)

    van der Haar, Frits; Gerasimov, Gregory; Tyler, Vilma Qahoush; Timmer, Arnold

    2011-12-01

    By 2000, the global track record on universal salt iodization (USI) indicated 26% access to adequately iodized salt in the Central and Eastern Europe, Commonwealth of Independent States (CEE/ CIS) Region. Aimed at extracting lessons learned, this study examined experiences, achievements, and outcomes of USI strategies in CEE/CIS countries during the subsequent decade. Information from the design, timing, execution, outputs, multi-sector management and results of actions by national stakeholders yielded 20 country summaries. Analysis across countries used a LogFrame Analysis typical for public nutrition development. By 2009, USI strategies had reached the target and population iodine nutrition shown adequate levels in 9 countries, while in 6 others, USI was close and/or population iodine status showed only minor imperfection. True USI, i.e., iodization of salt destined both for the food industry and the household, had been made mandatory in 13 of these 15 countries. In the Balkan area, USI and iodine nutrition advanced more than in CIS. Of the 20 sample countries, 17 (85%) had exceeded the mark of 50% adequate access, while the overall regional score reached 55% by 2010. Experience from this region suggests that strong partnership collaboration, a new concept in post-Soviet societies, was a major success factor. Voluntary iodization or focusing on household salt alone was less likely conducive for success. Achieving optimum iodine nutrition required the setting of proper iodine standard Weak political leadership insistence in the Russian Federation and Ukraine to embrace USI is the main factor why the region remains behind in the global progress.

  7. Unravelling the correlation between the aspect ratio of nanotubular structures and their electrochemical performance to achieve high-rate and long-life lithium-ion batteries.

    Science.gov (United States)

    Tang, Yuxin; Zhang, Yanyan; Deng, Jiyang; Qi, Dianpeng; Leow, Wan Ru; Wei, Jiaqi; Yin, Shengyan; Dong, Zhili; Yazami, Rachid; Chen, Zhong; Chen, Xiaodong

    2014-12-01

    The fundamental understanding of the relationship between the nanostructure of an electrode and its electrochemical performance is crucial for achieving high-performance lithium-ion batteries (LIBs). In this work, the relationship between the nanotubular aspect ratio and electrochemical performance of LIBs is elucidated for the first time. The stirring hydrothermal method was used to control the aspect ratio of viscous titanate nanotubes, which were used to fabricate additive-free TiO2 -based electrode materials. We found that the battery performance at high charging/discharging rates is dramatically boosted when the aspect ratio is increased, due to the optimization of electronic/ionic transport properties within the electrode materials. The proof-of-concept LIBs comprising nanotubes with an aspect ratio of 265 can retain more than 86 % of their initial capacity over 6000 cycles at a high rate of 30 C. Such devices with supercapacitor-like rate performance and battery-like capacity herald a new paradigm for energy storage systems.

  8. Observations of trace gases, photolysis rate coefficients and model simulations over semi-arid region, India

    Science.gov (United States)

    Lingaswamy, A. P.; Arafath, S. Md; Balakrishnaiah, G.; Rama Gopal, K.; Siva Kumar Reddy, N.; Raja Obul Reddy, K.; Reddy, R. R.; Chakradhar Rao, T.

    2017-06-01

    Continuous ground-based measurements of CO, SO2 and NO2 were carried out in a semi-arid rural area, Anantapur [14.62 0N, 77.65 0E], Southern India, for the period January 2012-December 2012. The maximum CO concentration was observed in winter (310 ± 17 ppbv) followed by summer (180 ± 21 ppbv) and post monsoon (174 ± 20 ppbv), while the minimum in monsoon (72 ± 9 ppbv). Seasonal mean NO2/NOx ratios for monsoon, post monsoon, winter and summer were about 0.88, 0.91, 0.76 and 0.80 respectively, indicating a higher conversion of NO to NO2 over the measurement site. Monthly mean low SO2 mixing ratio was found (0.46 ± 0.02 ppbv) in monsoon and high (2.42 ± 0.21 ppbv) in winter. Keeping the emissions aside, the levels of CO, SO2 and NO2 were influenced by meteorology, urban effects and trans-boundary transport in the lower troposphere. Atmospheric boundary layer (ABL) had the good correlation coefficient (R = 0.76) with solar radiation during daytime, while it was mainly correlated with wind speed during night time (R = 0.42). Diurnal trend of atmospheric visibility was found to be maximum during noon times at around (14:00-16:00 h) about 76 k.m. and minimum during morning periods (06:00-08:00 h) about 45 k.m. A strong positive correlation was observed between BC and CO (R = 0.71) with an average slope, suggesting common or proximate sources likely to be traffic emissions contribution for the production of BC and CO. The SO2/NOx and CO/NOx study were strongly suggested that mobile sources were larger contributors over the site and the evidence of transport of emissions from other surrounding regions. Tropospheric Ultraviolet Visible (TUV) radiative transfer model was used to calculate the Photolysis rate coefficients (J(O3), J(NO2)). Chemical box model (NCAR-MM) was used to simulate diurnal variation of CO and the results were reported.

  9. Regional oxygen reduction and denitrification rates in groundwater from multi-model residence time distributions, San Joaquin Valley, USA

    Science.gov (United States)

    Green, Christopher T.; Jurgens, Bryant C.; Zhang, Yong; Starn, J. Jeffrey; Singleton, Michael J.; Esser, Bradley K.

    2016-12-01

    Rates of oxygen and nitrate reduction are key factors in determining the chemical evolution of groundwater. Little is known about how these rates vary and covary in regional groundwater settings, as few studies have focused on regional datasets with multiple tracers and methods of analysis that account for effects of mixed residence times on apparent reaction rates. This study provides insight into the characteristics of residence times and rates of O2 reduction and denitrification (NO3- reduction) by comparing reaction rates using multi-model analytical residence time distributions (RTDs) applied to a data set of atmospheric tracers of groundwater age and geochemical data from 141 well samples in the Central Eastern San Joaquin Valley, CA. The RTD approach accounts for mixtures of residence times in a single sample to provide estimates of in-situ rates. Tracers included SF6, CFCs, 3H, He from 3H (tritiogenic He), 14C, and terrigenic He. Parameter estimation and multi-model averaging were used to establish RTDs with lower error variances than those produced by individual RTD models. The set of multi-model RTDs was used in combination with NO3- and dissolved gas data to estimate zero order and first order rates of O2 reduction and denitrification. Results indicated that O2 reduction and denitrification rates followed approximately log-normal distributions. Rates of O2 and NO3- reduction were correlated and, on an electron milliequivalent basis, denitrification rates tended to exceed O2 reduction rates. Estimated historical NO3- trends were similar to historical measurements. Results show that the multi-model approach can improve estimation of age distributions, and that relatively easily measured O2 rates can provide information about trends in denitrification rates, which are more difficult to estimate.

  10. Regional oxygen reduction and denitrification rates in groundwater from multi-model residence time distributions, San Joaquin Valley, USA

    Science.gov (United States)

    Green, Christopher T.; Jurgens, Bryant; Zhang, Yong; Starn, Jeffrey; Singleton, Michael J.; Esser, Bradley K.

    2016-01-01

    Rates of oxygen and nitrate reduction are key factors in determining the chemical evolution of groundwater. Little is known about how these rates vary and covary in regional groundwater settings, as few studies have focused on regional datasets with multiple tracers and methods of analysis that account for effects of mixed residence times on apparent reaction rates. This study provides insight into the characteristics of residence times and rates of O2 reduction and denitrification (NO3− reduction) by comparing reaction rates using multi-model analytical residence time distributions (RTDs) applied to a data set of atmospheric tracers of groundwater age and geochemical data from 141 well samples in the Central Eastern San Joaquin Valley, CA. The RTD approach accounts for mixtures of residence times in a single sample to provide estimates of in-situ rates. Tracers included SF6, CFCs, 3H, He from 3H (tritiogenic He),14C, and terrigenic He. Parameter estimation and multi-model averaging were used to establish RTDs with lower error variances than those produced by individual RTD models. The set of multi-model RTDs was used in combination with NO3− and dissolved gas data to estimate zero order and first order rates of O2 reduction and denitrification. Results indicated that O2 reduction and denitrification rates followed approximately log-normal distributions. Rates of O2 and NO3− reduction were correlated and, on an electron milliequivalent basis, denitrification rates tended to exceed O2 reduction rates. Estimated historical NO3− trends were similar to historical measurements. Results show that the multi-model approach can improve estimation of age distributions, and that relatively easily measured O2 rates can provide information about trends in denitrification rates, which are more difficult to estimate.

  11. Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes

    Directory of Open Access Journals (Sweden)

    Christina L. Zheng

    2014-11-01

    Full Text Available Somatic mutations in cancer are more frequent in heterochromatic and late-replicating regions of the genome. We report that regional disparities in mutation density are virtually abolished within transcriptionally silent genomic regions of cutaneous squamous cell carcinomas (cSCCs arising in an XPC−/− background. XPC−/− cells lack global genome nucleotide excision repair (GG-NER, thus establishing differential access of DNA repair machinery within chromatin-rich regions of the genome as the primary cause for the regional disparity. Strikingly, we find that increasing levels of transcription reduce mutation prevalence on both strands of gene bodies embedded within H3K9me3-dense regions, and only to those levels observed in H3K9me3-sparse regions, also in an XPC-dependent manner. Therefore, transcription appears to reduce mutation prevalence specifically by relieving the constraints imposed by chromatin structure on DNA repair. We model this relationship among transcription, chromatin state, and DNA repair, revealing a new, personalized determinant of cancer risk.

  12. Regional changes over time in initial virological response rates to combination antiretroviral therapy across Europe

    DEFF Research Database (Denmark)

    Bannister, W; Kirk, O; Gatell, J;

    2006-01-01

    BACKGROUND: Changes in virologic response to initial combination antiretroviral therapy (cART) over calendar time may indicate improvements in cART or emergence of primary resistance. Regional variations may identify differences in available antiretroviral drugs or patient management. METHODS......: Virologic response (viral load Virologic.......026) and time (P virologic response after adjustment for confounders. Stratified by period, regional differences were less evident (early cART, P = 0.967; mid cART, P = 0.291; late cART, P = 0.163). Stratified by region, temporal changes were observed (south, P = 0.061; central west, P

  13. Using First-Grade Teacher Ratings to Predict Third-Grade English Language Arts and Mathematics Achievement on a High-Stakes Statewide Assessment

    Directory of Open Access Journals (Sweden)

    Dorinda J. GALLANT

    2013-03-01

    Full Text Available Early childhood professional organizations support teachers as the best assessors of students’ academic, social, emotional, and physical development. This study investigates the predictive nature of teacher ratings of first-grade students’ performance on a standards-based curriculum-embedded performance assessment within the context of a state accountability system. The sample includes 4292 elementary school students cross-classified by 131 first-grade and 137 third-grade schools attended. This study uses extant statewide assessment data for students located in a state in the southeastern part of the United States. Controlling for student and school demographic variables in cross-classified random effects multilevel models, first-grade teacher ratings—as reflected by domain scores on a performance assessment—are found to positively and significantly correlate with students’ third-grade academic achievement.

  14. A theoretical model for Reynolds-stress and dissipation-rate budgets in near-wall region

    Institute of Scientific and Technical Information of China (English)

    陆利蓬; 陈矛章

    2000-01-01

    A 3-D wave model for the turbulent coherent structures in near-wall region is proposed. The transport nature of the Reynolds stresses and dissipation rate of the turbulence kinetic energy are shown via computation based on the theoretical model. The mean velocity profile is also computed by using the same theoretical model. The theoretical results are in good agreement with those found from DNS, indicating that the theoretical model proposed can correctly describe the physical mechanism of turbulence in near wail region and it thus possibly opens a new way for turbulence modeling in this region.

  15. A theoretical model for Reynolds-stress and dissipation-rate budgets in near-wall region

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A 3-D wave model for the turbulent coherent structures in near-wall region is proposed. The transport nature of the Reynolds stresses and dissipation rate of the turbulence kinetic energy are shown via computation based on the theoretical model. The mean velocity profile is also computed by using the same theoretical model. The theoretical results are in good agreement with those found from DNS, indicating that the theoretical model proposed can correctly describe the physical mechanism of turbulence in near wall region and it thus possibly opens a new way for turbulence modeling in this region.

  16. Regional changes over time in initial virologic response rates to combination antiretroviral therapy across Europe

    DEFF Research Database (Denmark)

    Bannister, Wendy P; Kirk, Ole; Gatell, Jose M;

    2006-01-01

    : Virologic response (viral load SIDA patients. Analyses were stratified by region (south, central west, north, east) or time started cART (early, 1996-1997; mid, 1998-1999; late, 2000-1904). RESULTS: Virologic...

  17. Regional suicide rates in the Netherlands : does religion still play a role?

    NARCIS (Netherlands)

    Neeleman, J

    1998-01-01

    Background This study examined the nature of ecological associations between 'religiousness' and suicide rates (1985-1994) in the 11 provinces in the Netherlands. Methods Indices of religiousness, obtained from a nationwide survey were used as aggregate predictors of provincial suicide rates in weig

  18. Self-rated health and quality of life in adults attending regional disability services in Ireland.

    LENUS (Irish Health Repository)

    Boland, Máirín C

    2009-04-01

    There is limited background information on self-rated health in people with disability in Ireland. This paper examines self-rated health scores and dimensions of functioning in people attending disability services and compares scores to the general population in Ireland, which has not been done before.

  19. Regional suicide rates in the Netherlands : does religion still play a role?

    NARCIS (Netherlands)

    Neeleman, J

    Background This study examined the nature of ecological associations between 'religiousness' and suicide rates (1985-1994) in the 11 provinces in the Netherlands. Methods Indices of religiousness, obtained from a nationwide survey were used as aggregate predictors of provincial suicide rates in

  20. Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies

    Directory of Open Access Journals (Sweden)

    Elijah Mak

    2015-01-01

    Conclusions: AD showed a faster rate of global brain atrophy compared to DLB, which had similar rates of atrophy to HC. Among dementia subjects, younger age was associated with accelerated atrophy, reflecting more aggressive disease in younger people. PBVC could aid in differentiating between DLB and AD, however its utility as an outcome marker in DLB is limited.

  1. Regional suicide rates in the Netherlands : does religion still play a role?

    NARCIS (Netherlands)

    Neeleman, J

    1998-01-01

    Background This study examined the nature of ecological associations between 'religiousness' and suicide rates (1985-1994) in the 11 provinces in the Netherlands. Methods Indices of religiousness, obtained from a nationwide survey were used as aggregate predictors of provincial suicide rates in weig

  2. Local, regional, and systemic recurrence rates in patients undergoing skin-sparing mastectomy compared with conventional mastectomy.

    Science.gov (United States)

    Yi, Min; Kronowitz, Steven J; Meric-Bernstam, Funda; Feig, Barry W; Symmans, W Fraser; Lucci, Anthony; Ross, Merrick I; Babiera, Gildy V; Kuerer, Henry M; Hunt, Kelly K

    2011-03-01

    Although the use of SSM is becoming more common, there are few data on long-term, local-regional, and distant recurrence rates after treatment. The purpose of this study was to examine the rates of local, regional, and systemic recurrence, and survival in breast cancer patients who underwent skin-sparing mastectomy (SSM) or conventional mastectomy (CM) at our institution. Patients with stage 0 to III unilateral breast cancer who underwent total mastectomy at our center from 2000 to 2005 were included in this study. Kaplan-Meier curves were calculated, and the log-rank test was used to evaluate the differences between overall and disease-free survival rates in the 2 groups. Of 1810 patients, 799 (44.1%) underwent SSM and 1011 (55.9%) underwent CM. Patients who underwent CM were older (58.3 vs 49.3 years, P<.0001) and were more likely to have stage IIB or III disease (53.0% vs 31.8%, P<.0001). Significantly more patients in the CM group received neoadjuvant chemotherapy and adjuvant radiation therapy (P<.0001). At a median follow-up of 53 months, 119 patients (6.6%) had local, regional, or systemic recurrences. The local, regional, and systemic recurrence rates did not differ significantly between the SSM and CM groups. After adjusting for clinical TNM stage and age, disease-free survival rates between the SSM and CM groups did not differ significantly. SSM is an acceptable treatment option for patients who are candidates for immediate breast reconstruction. Local-regional recurrence rates are similar to those of patients undergoing CM. Cancer 2011. © 2010 American Cancer Society. Copyright © 2010 American Cancer Society.

  3. Natural background radiation and estimation of gonadal dose rate of population of Chittagong region

    Energy Technology Data Exchange (ETDEWEB)

    Mostofa, M.N.; Ahmed, J.U. (Chittagong Univ. (Bangladesh). Dept. of Physics); Ahmed, R.; Ishaque, A.M. (Nuclear Medicine Center, Chittagong (Bangladesh)); Ahmed, K. (Institute of Nuclear Medicine, Dacca (Bangladesh))

    1981-07-01

    A survey was made on the background radiation to estimate the gonadal dose rate in the district of Chittagong from the year 1978 to 80. This was done with the help of a calibrated Nuclear Chicago transistorized survey meter. The measurements were made in different types of dwellings and occupational buildings constructed with wood, straw/bamboo, tin/bamboo, tin/brick and single and multistoried buildings of brick and concrete. For measurement of outdoor radiation the investigating areas taken were the roads, fields and the Karnafuly river. The variation in the population dose rate as well as gonadal dose rate were observed in different types of dwellings and occupational buildings including outdoors. The average population dose rate including cosmic ray intensity was found to be 172.41+-8.61 mrad/year. Thus, the annual gonadal dose rate due to gamma radiation was found to be 137.92+-6.89 mrad/year.

  4. Regions of High Out-Of-Hospital Cardiac Arrest Incidence and Low Bystander CPR Rates in Victoria, Australia

    Science.gov (United States)

    Straney, Lahn D.; Bray, Janet E.; Beck, Ben; Finn, Judith; Bernard, Stephen; Dyson, Kylie; Lijovic, Marijana; Smith, Karen

    2015-01-01

    Background Out-of-hospital cardiac arrest (OHCA) remains a major public health issue and research has shown that large regional variation in outcomes exists. Of the interventions associated with survival, the provision of bystander CPR is one of the most important modifiable factors. The aim of this study is to identify census areas with high incidence of OHCA and low rates of bystander CPR in Victoria, Australia Methods We conducted an observational study using prospectively collected population-based OHCA data from the state of Victoria in Australia. Using ArcGIS (ArcMap 10.0), we linked the location of the arrest using the dispatch coordinates (longitude and latitude) to Victorian Local Government Areas (LGAs). We used Bayesian hierarchical models with random effects on each LGA to provide shrunken estimates of the rates of bystander CPR and the incidence rates. Results Over the study period there were 31,019 adult OHCA attended, of which 21,436 (69.1%) cases were of presumed cardiac etiology. Significant variation in the incidence of OHCA among LGAs was observed. There was a 3 fold difference in the incidence rate between the lowest and highest LGAs, ranging from 38.5 to 115.1 cases per 100,000 person-years. The overall rate of bystander CPR for bystander witnessed OHCAs was 62.4%, with the rate increasing from 56.4% in 2008–2010 to 68.6% in 2010–2013. There was a 25.1% absolute difference in bystander CPR rates between the highest and lowest LGAs. Conclusion Significant regional variation in OHCA incidence and bystander CPR rates exists throughout Victoria. Regions with high incidence and low bystander CPR participation can be identified and would make suitable targets for interventions to improve CPR participation rates. PMID:26447844

  5. Regions of High Out-Of-Hospital Cardiac Arrest Incidence and Low Bystander CPR Rates in Victoria, Australia.

    Directory of Open Access Journals (Sweden)

    Lahn D Straney

    Full Text Available Out-of-hospital cardiac arrest (OHCA remains a major public health issue and research has shown that large regional variation in outcomes exists. Of the interventions associated with survival, the provision of bystander CPR is one of the most important modifiable factors. The aim of this study is to identify census areas with high incidence of OHCA and low rates of bystander CPR in Victoria, Australia.We conducted an observational study using prospectively collected population-based OHCA data from the state of Victoria in Australia. Using ArcGIS (ArcMap 10.0, we linked the location of the arrest using the dispatch coordinates (longitude and latitude to Victorian Local Government Areas (LGAs. We used Bayesian hierarchical models with random effects on each LGA to provide shrunken estimates of the rates of bystander CPR and the incidence rates.Over the study period there were 31,019 adult OHCA attended, of which 21,436 (69.1% cases were of presumed cardiac etiology. Significant variation in the incidence of OHCA among LGAs was observed. There was a 3 fold difference in the incidence rate between the lowest and highest LGAs, ranging from 38.5 to 115.1 cases per 100,000 person-years. The overall rate of bystander CPR for bystander witnessed OHCAs was 62.4%, with the rate increasing from 56.4% in 2008-2010 to 68.6% in 2010-2013. There was a 25.1% absolute difference in bystander CPR rates between the highest and lowest LGAs.Significant regional variation in OHCA incidence and bystander CPR rates exists throughout Victoria. Regions with high incidence and low bystander CPR participation can be identified and would make suitable targets for interventions to improve CPR participation rates.

  6. Regions of High Out-Of-Hospital Cardiac Arrest Incidence and Low Bystander CPR Rates in Victoria, Australia.

    Science.gov (United States)

    Straney, Lahn D; Bray, Janet E; Beck, Ben; Finn, Judith; Bernard, Stephen; Dyson, Kylie; Lijovic, Marijana; Smith, Karen

    2015-01-01

    Out-of-hospital cardiac arrest (OHCA) remains a major public health issue and research has shown that large regional variation in outcomes exists. Of the interventions associated with survival, the provision of bystander CPR is one of the most important modifiable factors. The aim of this study is to identify census areas with high incidence of OHCA and low rates of bystander CPR in Victoria, Australia. We conducted an observational study using prospectively collected population-based OHCA data from the state of Victoria in Australia. Using ArcGIS (ArcMap 10.0), we linked the location of the arrest using the dispatch coordinates (longitude and latitude) to Victorian Local Government Areas (LGAs). We used Bayesian hierarchical models with random effects on each LGA to provide shrunken estimates of the rates of bystander CPR and the incidence rates. Over the study period there were 31,019 adult OHCA attended, of which 21,436 (69.1%) cases were of presumed cardiac etiology. Significant variation in the incidence of OHCA among LGAs was observed. There was a 3 fold difference in the incidence rate between the lowest and highest LGAs, ranging from 38.5 to 115.1 cases per 100,000 person-years. The overall rate of bystander CPR for bystander witnessed OHCAs was 62.4%, with the rate increasing from 56.4% in 2008-2010 to 68.6% in 2010-2013. There was a 25.1% absolute difference in bystander CPR rates between the highest and lowest LGAs. Significant regional variation in OHCA incidence and bystander CPR rates exists throughout Victoria. Regions with high incidence and low bystander CPR participation can be identified and would make suitable targets for interventions to improve CPR participation rates.

  7. A study of the potentials achieved during mechanical abrasion and the repassivation rate of titanium and Ti6A14V in inorganic buffer solutions and bovine serum

    Energy Technology Data Exchange (ETDEWEB)

    Contu, F. [University of Mississippi Medical Center, Jackson, MS (United States); Elsener, B. [University of Cagliari (Italy). Dept. of Inorganic and Anlaytical Chemistry; Swiss Federal Institute of Technology, Zurich (Switzerland). Institute of Materials Chemistry; Boehni, H. [Swiss Federal Institute of Technology, Zurich (Switzerland). Institute of Materials Chemistry

    2004-11-15

    Titanium alloys in orthopaedic implants are susceptible to mechanical disruption of the passive film (fretting corrosion). To study this effect, open-circuit potential (ocp) measurements before, during and after mechanical disruption of the passive film in a tribo-electrochemical cell on commercial pure titanium, and Ti6Al4V alloy in inorganic buffer solutions in the pH range from 2.0 to 12.0 and calf bovine serum at pH 4.0 and 7.0 are reported. Additionally, the effect of pH, electrolyte and sample composition on the repassivation rate has been investigated. The potentials achieved during the abrasion of Ti6Al4V are the same as those characterizing pure titanium, which indicates that the corrosion current of both materials in the active state is due to the oxidation of titanium. However, commercial pure titanium displays a tendency to repassivate faster than Ti6Al4V in inorganic buffer solutions thanks to the lower critical current density and the higher catalytic activity towards the hydrogen evolution reaction observed on the pure metal in comparison with the alloy. Proteinaceous solutions like bovine serum, significantly slow down the anodic dissolution and the cathodic reactions both on titanium and the alloy. However, the repassivation rate of the Ti6Al4V is not affected by serum, while that of cp titanium significantly decreases both at pH 4.0 and 7.0. (author)

  8. Clay sediment accumulation rates on the monsoon-dominated western continental shelf and slope region of India

    Digital Repository Service at National Institute of Oceanography (India)

    Borole, D.V.

    Clay accumulation rates shown in sediment cores from the nearshore to outer continental shelf and slope regions in water depths of 10-1246 m on the western continental margins of India were determined by the 210Pb dating technique. The 210Pb excess...

  9. Rain rate intensity model for communication link design across the Indian region

    Science.gov (United States)

    Kilaru, Aravind; Kotamraju, Sarat K.; Avlonitis, Nicholas; Sri Kavya, K. Ch.

    2016-07-01

    A study on rain statistical parameters such as one minute rain intensity, possible number of minute occurrences with respective percentage of time in a year has been evaluated for the purpose of communication link design at Ka, Q, V bands as well as at Free-Space Optical communication links (FSO). To understand possible outage period of a communication links due to rainfall and to investigate rainfall pattern, Automatic Weather Station (AWS) rainfall data is analysed due its ample presence across India. The climates of the examined AWS regions vary from desert to cold climate, heavy rainfall to variable rainfall regions, cyclone effective regions, mountain and coastal regions. In this way a complete and unbiased picture of the rainfall statistics for Indian region is evaluated. The analysed AWS data gives insight into yearly accumulated rainfall, maximum hourly accumulated rainfall, mean hourly accumulated rainfall, number of rainy days and number of rainy hours from 668 AWS locations. Using probability density function the one minute rainfall measurements at KL University is integrated with AWS measurements for estimating number of rain occurrences in terms of one minute rain intensity for annual rainfall accumulated between 100 mm and 5000 mm to give an insight into possible one minute accumulation pattern in an hour for comprehensive analysis of rainfall influence on a communication link for design engineers. So that low availability communications links at higher frequencies can be transformed into a reliable and economically feasible communication links for implementing High Throughput Services (HTS).

  10. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 8 - Denver

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  11. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 4 - Atlanta

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  12. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 6 - Dallas

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  13. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 3 - Philadelphia

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  14. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, HHS Region 1 - Boston

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  15. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 5 - Chicago

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  16. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 2 - New York

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  17. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 7 - Kansas City

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  18. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 5 - Chicago

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  19. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 9 - San Francisco

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  20. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 7 - Kansas City

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  1. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 4 - Atlanta

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  2. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 2 - New York

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  3. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 10 - Seattle

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  4. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 3 - Philadelphia

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  5. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 8 - Denver

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  6. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 1 - Boston

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  7. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 6 - Dallas

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  8. Motor Vehicle Occupant Death Rate, by Age and Gender, 2012 & 2014, Region 10 - Seattle

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System...

  9. Impaired Driving Death Rate, by Age and Gender, 2012 & 2014, Region 9 - San Francisco

    Data.gov (United States)

    U.S. Department of Health & Human Services — Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis...

  10. Identification and characterization of genomic regions on chromosomes 4 and 8 that control the rate of photosynthesis in rice leaves

    Science.gov (United States)

    Adachi, Shunsuke; Tsuru, Yukiko; Nito, Naoko; Murata, Kazumasa; Yamamoto, Toshio; Ebitani, Takeshi; Ookawa, Taiichiro; Hirasawa, Tadashi

    2011-01-01

    DNA marker-assisted selection appears to be a promising strategy for improving rates of leaf photosynthesis in rice. The rate of leaf photosynthesis was significantly higher in a high-yielding indica variety, Habataki, than in the most popular Japanese variety, Koshihikari, at the full heading stage as a result of the higher level of leaf nitrogen at the same rate of application of nitrogen and the higher stomatal conductance even when the respective levels of leaf nitrogen were the same. The higher leaf nitrogen content of Habataki was caused by the greater accumulation of nitrogen by plants. The higher stomatal conductance of Habataki was caused by the higher hydraulic conductance. Using progeny populations and selected lines derived from a cross between Koshihikari and Habataki, it was possible to identify the genomic regions responsible for the rate of photosynthesis within a 2.1 Mb region between RM17459 and RM17552 and within a 1.2 Mb region between RM6999 and RM22529 on the long arm of chromosome 4 and on the short arm of chromosome 8, respectively. The designated region on chromosome 4 of Habataki was responsible for both the increase in the nitrogen content of leaves and hydraulic conductance in the plant by increasing the root surface area. The designated region on chromosome 8 of Habataki was responsible for the increase in hydraulic conductance by increasing the root hydraulic conductivity. The results suggest that it may be possible to improve photosynthesis in rice leaves by marker-assisted selection that focuses on these regions of chromosomes 4 and 8. PMID:21296764

  11. Identification and characterization of genomic regions on chromosomes 4 and 8 that control the rate of photosynthesis in rice leaves.

    Science.gov (United States)

    Adachi, Shunsuke; Tsuru, Yukiko; Nito, Naoko; Murata, Kazumasa; Yamamoto, Toshio; Ebitani, Takeshi; Ookawa, Taiichiro; Hirasawa, Tadashi

    2011-03-01

    DNA marker-assisted selection appears to be a promising strategy for improving rates of leaf photosynthesis in rice. The rate of leaf photosynthesis was significantly higher in a high-yielding indica variety, Habataki, than in the most popular Japanese variety, Koshihikari, at the full heading stage as a result of the higher level of leaf nitrogen at the same rate of application of nitrogen and the higher stomatal conductance even when the respective levels of leaf nitrogen were the same. The higher leaf nitrogen content of Habataki was caused by the greater accumulation of nitrogen by plants. The higher stomatal conductance of Habataki was caused by the higher hydraulic conductance. Using progeny populations and selected lines derived from a cross between Koshihikari and Habataki, it was possible to identify the genomic regions responsible for the rate of photosynthesis within a 2.1 Mb region between RM17459 and RM17552 and within a 1.2 Mb region between RM6999 and RM22529 on the long arm of chromosome 4 and on the short arm of chromosome 8, respectively. The designated region on chromosome 4 of Habataki was responsible for both the increase in the nitrogen content of leaves and hydraulic conductance in the plant by increasing the root surface area. The designated region on chromosome 8 of Habataki was responsible for the increase in hydraulic conductance by increasing the root hydraulic conductivity. The results suggest that it may be possible to improve photosynthesis in rice leaves by marker-assisted selection that focuses on these regions of chromosomes 4 and 8.

  12. Modeling climate effects on hip fracture rate by the multivariate GARCH model in Montreal region, Canada

    Science.gov (United States)

    Modarres, Reza; Ouarda, Taha B. M. J.; Vanasse, Alain; Orzanco, Maria Gabriela; Gosselin, Pierre

    2014-07-01

    Changes in extreme meteorological variables and the demographic shift towards an older population have made it important to investigate the association of climate variables and hip fracture by advanced methods in order to determine the climate variables that most affect hip fracture incidence. The nonlinear autoregressive moving average with exogenous variable-generalized autoregressive conditional heteroscedasticity (ARMA X-GARCH) and multivariate GARCH (MGARCH) time series approaches were applied to investigate the nonlinear association between hip fracture rate in female and male patients aged 40-74 and 75+ years and climate variables in the period of 1993-2004, in Montreal, Canada. The models describe 50-56 % of daily variation in hip fracture rate and identify snow depth, air temperature, day length and air pressure as the influencing variables on the time-varying mean and variance of the hip fracture rate. The conditional covariance between climate variables and hip fracture rate is increasing exponentially, showing that the effect of climate variables on hip fracture rate is most acute when rates are high and climate conditions are at their worst. In Montreal, climate variables, particularly snow depth and air temperature, appear to be important predictors of hip fracture incidence. The association of climate variables and hip fracture does not seem to change linearly with time, but increases exponentially under harsh climate conditions. The results of this study can be used to provide an adaptive climate-related public health program and ti guide allocation of services for avoiding hip fracture risk.

  13. Conditionally-Sampled Turbulent and Nonturbulent Measurements of Entropy Generation Rate in the Transition Region of Boundary Layers

    Energy Technology Data Exchange (ETDEWEB)

    D. M. McEligot; J. R. Wolf; K. P. Nolan; E. J. Walsh; R. J. Volino

    2006-05-01

    Conditionally-sampled boundary layer data for an accelerating transitional boundary layer have been analyzed to calculate the entropy generation rate in the transition region. By weighing the nondimensional dissipation coefficient for the laminar-conditioned-data and turbulent-conditioned-data with the intermittency factor the average entropy generation rate in the transition region can be determined and hence be compared to the time averaged data and correlations for steady laminar and turbulent flows. It is demonstrated that this method provides, for the first time, an accurate and detailed picture of the entropy generation rate during transition. The data used in this paper have been taken from detailed boundary layer measurements available in the literature. This paper provides, using an intermittency weighted approach, a methodology for predicting entropy generation in a transitional boundary layer.

  14. Conditionally-Sampled Turbulent and Non-turbulent Measurements of Entropy Generation Rate in the Transition Region of Boundary Layers

    Energy Technology Data Exchange (ETDEWEB)

    Edmond J. Walsh; Kevin P. Nolan; Donald M. McEligot; Ralph J. Volino; Adrian Bejan

    2007-05-01

    Conditionally-sampled boundary layer data for an accelerating transitional boundary layer have been analyzed to calculate the entropy generation rate in the transition region. By weighing the nondimensional dissipation coefficient for the laminar-conditioned-data and turbulent-conditioned-data with the intermittency factor the average entropy generation rate in the transition region can be determined and hence be compared to the time averaged data and correlations for steady laminar and turbulent flows. It is demonstrated that this method provides, for the first time, an accurate and detailed picture of the entropy generation rate during transition. The data used in this paper have been taken from detailed boundary layer measurements available in the literature. This paper provides, using an intermittency weighted approach, a methodology for predicting entropy generation in a transitional boundary layer.

  15. The Differential Effect of Ultraviolet Light Exposure on Cataract Rate across Regions of the Lens

    OpenAIRE

    Abraham, Alison G.; Cox, Christopher; West, Sheila

    2010-01-01

    This study was an investigation of the effect of ultraviolet B light exposure on the risk of cortical cataract as a function of the region of the lens. The degree to which the lower nasal predominance of cortical cataract is a result of UVB exposure was assessed.

  16. Neutron and Gamma Fluxes and dpa Rates for HFIR Vessel Beltline Region (Present and Upgrade Designs)

    Energy Technology Data Exchange (ETDEWEB)

    Blakeman, E.D.

    2001-01-11

    The Oak Ridge National Laboratory (ORNL) High Flux Isotope Reactor (HFIR) is currently undergoing an upgrading program, a part of which is to increase the diameters of two of the four radiation beam tubes (HB-2 and HB-4). This change will cause increased neutron and gamma radiation dose rates at and near locations where the tubes penetrate the vessel wall. Consequently, the rate of radiation damage to the reactor vessel wall at those locations will also increase. This report summarizes calculations of the neutron and gamma flux (particles/cm{sup 2}/s) and the dpa rate (displacements/atom/s) in iron at critical locations in the vessel wall. The calculated dpa rate values have been recently incorporated into statistical damage evaluation codes used in the assessment of radiation induced embrittlement. Calculations were performed using models based on the discrete ordinates methodology and utilizing ORNL two-dimensional and three-dimensional discrete ordinates codes. Models for present and proposed beam tube designs are shown and their results are compared. Results show that for HB-2, the dpa rate in the vessel wall where the tube penetrates the vessel will be increased by {approximately}10 by the proposed enlargement. For HB-4, a smaller increase of {approximately}2.6 is calculated.

  17. Regional variations in mortality rates of pancreatic cancer in China:Results from 1990-1992 national mortality survey

    Institute of Scientific and Technical Information of China (English)

    Ke-Xin Chen; Peizhong Peter Wang; Si-Wei Zhang; Lian-Di Li; Feng-Zhu Lu; Xi-Shan Hao

    2003-01-01

    AIM: To examine the regional variations in mortality rates of pancreatic cancer in China.METHODS: Aggregated mortality data of pancreatic cancer were extracted from the 1990-1992 national death of all causes and its mortality survey in China. Age specific and standardized mortality rates were calculated at both national and provincial levels with selected characteristics including sex and residence status.RESULTS: Mortality of pancreatic cancer ranked the ninth and accounted for 1.38 percent of the total malignancy deaths. The crude and age standardized mortality rates of pancreatic cancer in China in the period of 1990-1992 were 1.48/100 000 and 1.30/100 000, respectively. Substantial regional variations in mortality rates across China were observed with adjusted mortality rates ranging from 0.43/100 000 to 3.70/100 000 with an extremal value of 8.7.Urban residents had significant higher pancreatic mortality than rural residents.CONCLUSION: The findings of this study show different mortality rates of this disease and highlight the importance of further investigation on factors, which might contribute to the observed epidemiological patterns.

  18. Correlated and Uncorrelated Regions in Heart-Rate Fluctuations during Sleep

    Science.gov (United States)

    Bunde, Armin; Havlin, Shlomo; Kantelhardt, Jan W.; Penzel, Thomas; Peter, Jörg-Hermann; Voigt, Karlheinz

    2000-10-01

    Healthy sleep consists of several stages: deep sleep, light sleep, and rapid eye movement (REM) sleep. Here we show that these sleep stages can be characterized and distinguished by correlations of heart rates separated by n beats. Using the detrended fluctuation analysis (DFA) up to fourth order we find that long-range correlations reminiscent to the wake phase are present only in the REM phase. In the non-REM phases, the heart rates are uncorrelated above the typical breathing cycle time, pointing to a random regulation of the heartbeat during non-REM sleep.

  19. Specific cerebellar regions are related to force amplitude and rate of force development

    OpenAIRE

    Spraker, M B.; Corcos, D.M.; Kurani, A.S.; Prodoehl, J; Swinnen, S.P.; Vaillancourt, D E

    2011-01-01

    The human cerebellum has been implicated in the control of a wide variety of motor control parameters, such as force amplitude, movement extent, and movement velocity. These parameters often covary in both movement and isometric force production tasks, so it is difficult to resolve whether specific regions of the cerebellum relate to specific parameters. In order to address this issue, the current study used two experiments and SUIT normalization to determine whether BOLD activation in the ce...

  20. Regional economic impacts of changes in electricity rates resulting from Western Area Power Administration`s power marketing alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Allison, T.; Griffes, P.; Edwards, B.K.

    1995-03-01

    This technical memorandum describes an analysis of regional economic impacts resulting from changes in retail electricity rates due to six power marketing programs proposed by Western Area Power Administration (Western). Regional economic impacts of changes in rates are estimated in terms of five key regional economic variables: population, gross regional product, disposable income, employment, and household income. The REMI (Regional Impact Models, Inc.) and IMPLAN (Impact Analysis for Planning) models simulate economic impacts in nine subregions in the area in which Western power is sold for the years 1993, 2000, and 2008. Estimates show that impacts on aggregate economic activity in any of the subregions or years would be minimal for three reasons. First, the utilities that buy power from Western sell only a relatively small proportion of the total electricity sold in any of the subregions. Second, reliance of Western customers on Western power is fairly low in each subregion. Finally, electricity is not a significant input cost for any industry or for households in any subregion.

  1. Precursory seismicity in regions of low strain rate: Insights from a physics-based earthquake23 simulator

    Science.gov (United States)

    Christophersen, Annemarie; Rhoades, David A.; Colella, Harmony V.

    2017-03-01

    The well-established earthquake forecasting model 'Every Earthquake a Precursor According to Scale' (EEPAS) is based on the observation that the magnitude and rate of minor earthquakes increases prior to large earthquakes. The precursor time is measured between this increase and the mainshock and is in the order of months to decades. Fitting the EEPAS model to different regional earthquake catalogues has indicated that the precursor time is longer in more slowly deforming tectonic environments. Examples from the stable continental region of Australia confirm this. To overcome the challenge of limited earthquake records in the analysis of the precursor time for areas with low strain rate, we use the physics-based earthquake simulator, RSQSim to generate a series of synthetic earthquake catalogues. A fault network with realistic complexity, is employed, based on the Wellington, New Zealand, fault network. The slip rates on faults are systematically reduced by five successive factors of 1/4. Fitting the EEPAS model to these synthetic catalogues shows that the precursor time is inversely proportional to the reduction in slip rate. Results suggest that the expected precursor times for large earthquakes in stable continental regions far exceed the length of available catalogues. The expected precursor time for the 2010 M7.1 Darfield, New Zealand, earthquake, which apparently had no precursory seismicity in the instrumental catalogue, also exceeds the length of the available catalogue. Therefore, applying the EEPAS model to physics-based simulators allows us to start understanding the phenomenon of precursory seismicity.

  2. Regional variations in nocturnal fluctuations in subcutaneous blood flow rate in the lower leg of man

    DEFF Research Database (Denmark)

    Sindrup, J H; Kastrup, J; Jørgensen, B

    1991-01-01

    aspect of the right lower leg of normal human subjects. In the present study subcutaneous adipose tissue blood flow rates were measured simultaneously in the right and left lower legs of 16 normal human subjects over 12-20 h ambulatory conditions. The 133Xe wash-out technique, portable CdTe(Cl) detectors...

  3. Deformation Rates in the Snake River Plain and Adjacent Basin and Range Regions Based on GPS Measurements

    Science.gov (United States)

    Payne, S. J.; McCaffrey, R.; King, R. W.; Kattenhorn, S. A.

    2012-12-01

    We estimate horizontal velocities for 405 sites using Global Positioning System (GPS) phase data collected from 1994 to 2010 within the Northern Basin and Range Province, U.S.A. The velocities reveal a slowly-deforming region within the Snake River Plain in Idaho and Owyhee-Oregon Plateau in Oregon separated from the actively extending adjacent Basin and Range regions by shear. Our results show a NE-oriented extensional strain rate of 5.6 ± 0.7 nanostrain/yr in the Centennial Tectonic Belt and an ~E-oriented extensional strain rate of 3.5 ± 0.2 nanostrain/yr in the Great Basin. These extensional rates contrast with the very low strain rate within the 125 km x 650 km region of the Snake River Plain and Owyhee-Oregon Plateau which is not distinguishable from zero (-0.1 ± 0.4 x nanostrain/yr). Inversions of Snake River Plain velocities with dike-opening models indicate that rapid extension by dike intrusion in volcanic rift zones, as previously hypothesized, is not currently occurring. GPS data also disclose that rapid extension in the surrounding regions adjacent to the slowly-deforming region of the Snake River Plain drives shear between them. We estimate right-lateral shear with slip rates of 0.3-1.5 mm/yr along the northwestern boundary adjacent to the Centennial Tectonic Belt and left-lateral oblique extension with slip rates of 0.5-1.5 mm/yr along the southeastern boundary adjacent to the Intermountain Seismic Belt. The fastest lateral shearing evident in the GPS occurs near the Yellowstone Plateau where earthquakes with right-lateral strike-slip focal mechanisms are within a NE-trending zone of seismicity. The regional velocity gradients are best fit by nearby poles of rotation for the Centennial Tectonic Belt, Snake River Plain, Owyhee-Oregon Plateau, and eastern Oregon, indicating that clockwise rotation is not locally driven by Yellowstone hotspot volcanism, but instead by extension to the south across the Wasatch fault possibly due to gravitational

  4. Investigating the variations in survival rates for very preterm infants in ten European regions: the MOSAIC birth cohort

    DEFF Research Database (Denmark)

    Draper, Elizabeth S; Zeitlin, Jennifer; Fenton, Alan C

    2008-01-01

    of the infants from 24 to 27 weeks gestation survived to discharge home from NIC. However large variations were seen in the timing of the deaths by region. Among all fetuses alive at onset of labour of 24-27 weeks gestation, between 84.0% and 98.9% were born alive and between 64.6% and 97.8% were admitted...... for NIC. For babies babies alive at onset of labour were admitted to neonatal intensive care. CONCLUSIONS: There are wide variations in the survival rates to discharge from NIC for very preterm deliveries and in the timing of death across the MOSAIC regions. In order...

  5. Acute Response of Well-Trained Sprinters to a 100-m Race: Higher Sprinting Velocity Achieved With Increased Step Rate Compared With Speed Training.

    Science.gov (United States)

    Otsuka, Mitsuo; Kawahara, Taisuke; Isaka, Tadao

    2016-03-01

    This study aimed to clarify the contribution of differences in step length and step rate to sprinting velocity in an athletic race compared with speed training. Nineteen well-trained male and female sprinters volunteered to participate in this study. Sprinting motions were recorded for each sprinter during both 100-m races and speed training (60-, 80-, and 100-m dash from a block start) for 14 days before the race. Repeated-measures analysis of covariance was used to compare the step characteristics and sprinting velocity between race and speed training, adjusted for covariates including race-training differences in the coefficients of restitution of the all-weather track, wind speed, air temperature, and sex. The average sprinting velocity to the 50-m mark was significantly greater in the race than in speed training (8.26 ± 0.22 m·s vs. 8.00 ± 0.70 m·s, p sprinters achieve higher sprinting velocity and can run with higher exercise intensity and more rapid motion during a race than during speed training, even if speed training was performed at perceived high intensity.

  6. Monetary policy, exchange rates and stock prices in the Middle East region

    OpenAIRE

    Abou Wafia, H.

    2015-01-01

    A structural vector autoregressive model is employed to investigate the impact of monetary policy and real exchange rate shocks on the stock market performance of Kuwait, Oman, Saudi Arabia, Egypt and Jordan. In order to identify the structural shocks both short run and long run restrictions are applied. Unlike previous literature the contemporaneous interdependence between the financial variables are left unrestricted to give a more accurate depiction of the relationships. The heterogeneity ...

  7. An alternative radiometric method for calculating the sedimentation rates: Application to an intertidal region (SW of Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Ligero, R.A., E-mail: rufino.ligero@uca.e [Departamento de Fisica Aplicada, Universidad de Cadiz, 11510 Puerto Real, Cadiz (Spain); Casas-Ruiz, M. [Departamento de Fisica Aplicada, Universidad de Cadiz, 11510 Puerto Real, Cadiz (Spain); Barrera, M. [Departamento de Medio Ambiente, CIEMAT, Madrid 28040 (Spain); Barbero, L. [Departamento de Ciencias de la Tierra, Universidad de Cadiz, 11510 Puerto Real (Spain); Melendez, M.J. [Departamento de Fisica Aplicada, Universidad de Cadiz, 11510 Puerto Real, Cadiz (Spain)

    2010-09-15

    A new method using the inventory determined for the activity of the radionuclide {sup 137}Cs, coming from global radioactive fallout has been utilised to calculate the sedimentation rates. The method has been applied in a wide intertidal region in the Bay of Cadiz Natural Park (SW Spain). The sedimentation rates estimated by the {sup 137}Cs inventory method ranged from 0.26 cm/year to 1.72 cm/year. The average value of the sedimentation rate obtained is 0.59 cm/year, and this rate has been compared with those resulting from the application of the {sup 210}Pb dating technique. A good agreement between the two procedures has been found. From the study carried out, it has been possible for the first time, to draw a map of sedimentation rates for this zone where numerous physico-chemical, oceanographic and ecological studies converge, since it is situated in a region of great environmental interest. This area, which is representative of common environmental coastal scenarios, is particularly sensitive to perturbations related to climate change, and the results of the study will allow to make short and medium term evaluations of this change.

  8. An alternative radiometric method for calculating the sedimentation rates: application to an intertidal region (SW of Spain).

    Science.gov (United States)

    Ligero, R A; Casas-Ruiz, M; Barrera, M; Barbero, L; Meléndez, M J

    2010-09-01

    A new method using the inventory determined for the activity of the radionuclide (137)Cs, coming from global radioactive fallout has been utilised to calculate the sedimentation rates. The method has been applied in a wide intertidal region in the Bay of Cádiz Natural Park (SW Spain). The sedimentation rates estimated by the (137)Cs inventory method ranged from 0.26 cm/year to 1.72 cm/year. The average value of the sedimentation rate obtained is 0.59 cm/year, and this rate has been compared with those resulting from the application of the (210)Pb dating technique. A good agreement between the two procedures has been found. From the study carried out, it has been possible for the first time, to draw a map of sedimentation rates for this zone where numerous physico-chemical, oceanographic and ecological studies converge, since it is situated in a region of great environmental interest. This area, which is representative of common environmental coastal scenarios, is particularly sensitive to perturbations related to climate change, and the results of the study will allow to make short and medium term evaluations of this change.

  9. Prevalence rates of helmet use among motorcycle riders in a developed region in China.

    Science.gov (United States)

    Xuequn, Yu; Ke, Liang; Ivers, Rebecca; Du, Wei; Senserrick, Teresa

    2011-01-01

    This study aimed to determine the prevalence rates of helmet use, and of correct helmet use (chinstrap firmly fastened) among motorcycle riders and their passengers in Zhongshan, Guangdong Province, China. A cross-sectional survey involving direct observation of motorcycle riders was conducted at 20 randomly selected intersections. A total of 13,410 motorcycles were observed during a 10-day period in February 2009. The overall prevalence of helmet use was 72.6% (95% CI: 71.8-73.3%) among drivers and 34.1% (95% CI: 32.7-35.5%) among pillion passengers. The prevalence of correct use was 43.2% (95% CI: 42.4-44.0%) and 20.9% (95% CI: 19.8-22.1%) for drivers and passengers respectively. The helmet wearing rate on city streets was almost 95%, however city riders were more likely than rural riders to wear non-motorcycle helmets while riding. In multivariate analyses, factors associated with increased helmet use included riding on city streets, male gender, being a driver, carrying less passengers and riding a registered motorcycle. The results indicated enforcement and education activities need to be strengthened with respect to both helmet use and helmet quality, especially in rural areas, in order to improve wearing rates.

  10. Description, evaluation and clinical decision making according to various fetal heart rate patterns. Inter-observer and regional variability

    DEFF Research Database (Denmark)

    1992-01-01

    At 10 Danish obstetrical departments, 116 residents (42 senior and 74 junior) participated in a study to assess inter-observer and regional variability in the description and evaluation of and clinical decision regarding 11 fetal heart rate patterns. The 11 traces included normal as well...... and the presence of silent or sinusoidal pattern (87-94% on an arbitrary 0-100% scale), and low regarding the assessment of variability and type of deceleration (50-72%). The degree of agreement in interpreting heart rate patterns was 59% (on an arbitrary 0-100% scale). Senior residents generally interpreted...

  11. A multi-region assessment of population rates of cardiac catheterization and yield of high-risk coronary artery disease

    Directory of Open Access Journals (Sweden)

    Clement Fiona M

    2011-11-01

    Full Text Available Abstract Background There is variation in cardiac catheterization utilization across jurisdictions. Previous work from Alberta, Canada, showed no evidence of a plateau in the yield of high-risk disease at cardiac catheterization rates as high as 600 per 100,000 population suggesting that the optimal rate is higher. This work aims 1 To determine if a previously demonstrated linear relationship between the yield of high-risk coronary disease and cardiac catheterization rates persists with contemporary data and 2 to explore whether the linear relationship exists in other jurisdictions. Methods Detailed clinical information on all patients undergoing cardiac catheterization in 3 Canadian provinces was available through the Alberta Provincial Project for Outcomes Assessment in Coronary Heart (APPROACH disease and partner initiatives in British Columbia and Nova Scotia. Population rates of catheterization and high-risk coronary disease detection for each health region in these three provinces, and age-adjusted rates produced using direct standardization. A mixed effects regression analysis was performed to assess the relationship between catheterization rate and high-risk coronary disease detection. Results In the contemporary Alberta data, we found a linear relationship between the population catheterization rate and the high-risk yield. Although the yield was slightly less in time period 2 (2002-2006 than in time period 1(1995-2001, there was no statistical evidence of a plateau. The linear relationship between catheterization rate and high-risk yield was similarly demonstrated in British Columbia and Nova Scotia and appears to extend, without a plateau in yield, to rates over 800 procedures per 100,000 population. Conclusions Our study demonstrates a consistent finding, over time and across jurisdictions, of linearly increasing detection of high-risk CAD as population rates of cardiac catheterization increase. This internationally-relevant finding

  12. Comparing the Rates of Dopamine Hemodynamic Effect Onset after Infusion through Peripheral Veins in Three Regions

    Directory of Open Access Journals (Sweden)

    Deokkyu Kim

    2017-02-01

    Full Text Available Background Dopamine is an inotropic agent that is often selected for continuous infusion. For hemodynamic stability, the rate of infusion is controlled in the range of 5-15 μg/kg/min. This study aimed to compare the time intervals from the administration of dopamine to the onset of its hemodynamic effects when dopamine was administered through three different peripheral veins (the cephalic vein [CV], the great saphenous vein [GSV], and the external jugular vein [EJV]. Methods Patients in group 1, group 2, and group 3 received dopamine infusions in the CV, GSV, and EJV, respectively. A noninvasive continuous cardiac output monitor (NICCOMO™, Medis, Ilmenau, Germany was used to assess cardiac output (CO and systemic vascular resistance (SVR. Six minutes after intubation, baseline heart rate (HR, systolic blood pressure (BP, diastolic BP, mean arterial pressure (MAP, CO, and SVR values were recorded and dopamine infusion was initiated at a dose of 10 μg/kg/min. Hemodynamic changes at 0, 4, 8, 12, and 15 minutes postinfusion were recorded. Results No statistically significant differences were observed among the three groups with respect to the rate of hemodynamic change. In all groups, systolic BP, diastolic BP, MAP, and SVR tended to increase after decreasing for the first 4 minutes; in contrast, HR and CO decreased until 8 minutes, after which they tended to reach a plateau. Conclusions For patients under general anesthesia receiving dopamine at 10 μg/kg/min, there were no clinical differences in the effect of dopamine administered through three different peripheral veins.

  13. Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction.

    Science.gov (United States)

    Heusch, Gerd; Skyschally, Andreas; Gres, Petra; van Caster, Patrick; Schilawa, Dustin; Schulz, Rainer

    2008-09-01

    Effects of the bradycardic agent ivabradine on regional blood flow, contractile function, and infarct size were studied in a pig model of myocardial ischaemia/reperfusion. Heart rate reduction by beta-blockade is associated with negative inotropism and unmasked alpha-adrenergic coronary vasoconstriction. Ivabradine is the only available bradycardic agent for clinical use. Anaesthetized pigs were subjected to 90 min controlled left anterior descending coronary artery hypoperfusion and 120 min reperfusion. Regional blood flow was measured with microspheres, regional function with sonomicrometry, and infarct size with triphenyl tetrazolium chloride staining. Pigs received placebo or ivabradine (0.6 mg/kg i.v.) before or during ischaemia or before reperfusion, respectively. Pre-treatment with ivabradine reduced infarct size from 35 +/- 4 (SEM) to 19 +/- 4% of area at risk (AAR). Ivabradine 15-20 min after the onset of ischaemia increased regional myocardial blood flow from 2.12 +/- 0.31 to 3.55 +/- 0.56 microL/beat/g and systolic wall thickening from 6.7 +/- 1.0 to 16.3 +/- 3.0%; infarct size was reduced from 12 +/- 4 to 2 +/- 1% of AAR. Ivabradine 5 min before reperfusion still reduced infarct size from 36 +/- 4 to 21 +/- 5% of AAR. The benefit of ivabradine on flow and function was eliminated by atrial pacing, but part of the reduction of infarct size by ivabradine was not. Ivabradine's protection goes beyond heart rate reduction.

  14. Role of climate variability in the heatstroke death rates of Kanto region in Japan.

    Science.gov (United States)

    Akihiko, Takaya; Morioka, Yushi; Behera, Swadhin K

    2014-07-10

    The death toll by heatstroke in Japan, especially in Kanto region, has sharply increased since 1994 together with large interannual variability. The surface air temperature and humidity observed during boreal summers of 1980-2010 were examined to understand the role of climate in the death toll. The extremely hot days, when the daily maximum temperature exceeds 35 °C, are more strongly associated with the death toll than the conventional Wet Bulb Globe Temperature index. The extremely hot days tend to be associated with El Niño/Southern Oscillation or the Indian Ocean Dipole, suggesting a potential link with tropical climate variability to the heatstroke related deaths. Also, the influence of these climate modes on the death toll has strengthened since 1994 probably related to global warming. It is possible to develop early warning systems based on seasonal climate predictions since recent climate models show excellent predictability skills for those climate modes.

  15. Regional trends in soil acidification and exchangeable metal concentrations in relation to acid deposition rates.

    Science.gov (United States)

    Stevens, Carly J; Dise, Nancy B; Gowing, David J

    2009-01-01

    The deposition of high levels of reactive nitrogen (N) and sulphur (S), or the legacy of that deposition, remain among the world's most important environmental problems. Although regional impacts of acid deposition in aquatic ecosystems have been well documented, quantitative evidence of wide-scale impacts on terrestrial ecosystems is not common. In this study we analysed surface and subsoil chemistry of 68 acid grassland sites across the UK along a gradient of acid deposition, and statistically related the concentrations of exchangeable soil metals (1 M KCl extraction) to a range of potential drivers. The deposition of N, S or acid deposition was the primary correlate for 8 of 13 exchangeable metals measured in the topsoil and 5 of 14 exchangeable metals in the subsoil. In particular, exchangeable aluminium and lead both show increased levels above a soil pH threshold of about 4.5, strongly related to the deposition flux of acid compounds.

  16. Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Fox, P.T.; Raichle, M.E.

    1984-05-01

    The purpose of this investigation was to determine the relationship between the repetition rate of a simple sensory stimulus and regional cerebral blood flow (rCBF) in the human brain. Positron emission tomography (PET), using intravenously administered H/sub 2/(/sup 15/)O as the diffusible blood-flow tracer, was employed for all CBF measurements. The use of H/sub 2/(/sup 15/)O with PET allowed eight CBF measurements to be made in rapid sequence under multiple stimulation conditions without removing the subject from the tomograph. Nine normal volunteers each underwent a series of eight H2(/sup 15/)O PET measurements of CBF. Initial and final scans were made during visual deprivation. The six intervening scans were made during visual activation with patterned-flash stimuli given in random order at 1.0-, 3.9-, 7.8-, 15.5-, 33.1-, and 61-Hz repetition rates. The region of greatest rCBF increase was determined. Within this region the rCBF was determined for every test condition and then expressed as the percentage change from the value of the initial unstimulated scan (rCBF% delta). In every subject, striate cortex rCBF% delta varied systematically with stimulus rate. Between 0 and 7.8 Hz, rCBF% delta was a linear function of stimulus repetition rate. The rCBF response peaked at 7.8 Hz and then declined. The rCBF% delta during visual stimulation was significantly greater than that during visual deprivation for every stimulus rate except 1.0 Hz. The anatomical localization of the region of peak rCBF response was determined for every subject to be the mesial occipital lobes along the calcarine fissure, primary visual cortex. Stimulus rate is a significant determinant of rCBF response in the visual cortex. Investigators of brain responses to selective activation procedures should be aware of the potential effects of stimulus rate on rCBF and other measurements of cerebral metabolism.

  17. Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies

    Science.gov (United States)

    Mak, Elijah; Su, Li; Williams, Guy B.; Watson, Rosie; Firbank, Michael; Blamire, Andrew M.; O'Brien, John T.

    2015-01-01

    Background & objective Percent whole brain volume change (PBVC) measured from serial MRI scans is widely accepted as a sensitive marker of disease progression in Alzheimer's disease (AD). However, the utility of PBVC in the differential diagnosis of dementia remains to be established. We compared PBVC in AD and dementia with Lewy bodies (DLB), and investigated associations with clinical measures. Methods 72 participants (14 DLBs, 25 ADs, and 33 healthy controls (HCs)) underwent clinical assessment and 3 Tesla T1-weighted MRI at baseline and repeated at 12 months. We used FSL-SIENA to estimate PBVC for each subject. Voxelwise analyses and ANCOVA compared PBVC between DLB and AD, while correlational tests examined associations of PBVC with clinical measures. Results AD had significantly greater atrophy over 1 year (1.8%) compared to DLB (1.0%; p = 0.01) and HC (0.9%; p atrophy rates (r = 0.49, p atrophy compared to DLB, which had similar rates of atrophy to HC. Among dementia subjects, younger age was associated with accelerated atrophy, reflecting more aggressive disease in younger people. PBVC could aid in differentiating between DLB and AD, however its utility as an outcome marker in DLB is limited. PMID:25685712

  18. Isolation rates of Burkholderia pseudomallei among the four regions in Thailand.

    Science.gov (United States)

    Leelarasamee, A; Trakulsomboon, S; Kusum, M; Dejsirilert, S

    1997-03-01

    This study aimed to compare the isolation rates of Burkholderia pseudomallei among community-based hospitals located in the central, north, northeast, and south of Thailand. A questionnaire inquiring about the number of isolation of B. pseudomallei from various clinical specimens during 1994-95 were mailed to 141 community-based hospitals. Of these, 125 hospitals (88.6%) responded to the questionnaire. Microbiological laboratory was not available in thirty hospitals. Data from 95 remaining hospitals with capability to do bacterial culture showed that B. pseudomallei was never isolated in 49 hospitals. Eleven, 9, 19 and 7 hospitals where B. pseudomallei has been isolated, are located in the central, north, northeast and south of Thailand respectively. From these 46 hospitals, a total of 1,131 strains of B. pseudomallei were isolated from 407,263 specimens in 1994 and 1,165 strains from 440,541 specimens in 1995. However, the isolation was most frequent in northeastern hospitals, which accounted for 890 and 964 strains in 1994 and 1995 respectively while only 94, 76, 71 and 83, 75, 43 strains were simultaneously isolated during the 2-year period in those located in central, north and south respectively. The isolation rates of B. speudomallei in 1994 and 1995 were 4.2 and 4.1 per 1,000 clinical specimens in northeastern hospitals as compared to 1.1, 1.8, 1.1 and 1.1, 1.2, 0.7 in those located in central, north and south respectively. Ubon Ratchathani, Nakhon Ratchasima, Buri Ram, Khon Kaen and Udon Thani were the five provinces which exhibited the highest isolation rates as follows; 244, 150, 147, 127, 100 and 218, 128, 114, 119, 58, in 1994 and 1995, respectively. It was concluded that B.pseudomallei was most commonly isolated in the northeast of Thailand. Under-recognition of B. pseudomallei may prevail not only in other parts of Thailand but in some areas of the northeast as well.

  19. Secular trends in caesarean section rates over 20 years in a regional obstetric unit in Hong Kong.

    Science.gov (United States)

    Chung, W H; Kong, C W; To, W Wk

    2017-08-01

    Although caesarean section rates have been increasing over the years in both public and private sectors in Hong Kong, there has been a paucity of formal surveys on local trends in such rates. This study aimed to examine the trends in caesarean section rates over a 20-year period at a public regional obstetric unit in Hong Kong using the Robson's Ten-group Classification System. All deliveries in a single obstetric unit during a 20-year period (1995-2014) were classified into 10 subgroups according to the Robson's classification. The annual caesarean section rate for each subgroup was calculated and then stratified into 5-year intervals to analyse any significant trends. The caesarean section rates in a total of 86 262 births with complete data were analysed. The overall caesarean section rate increased modestly from 15.4% to 24.6% during the study period. There was an obvious increasing trend for caesarean section in those with previous caesarean section (Robson's category 5), breech presentation at delivery (category 6 and 7), multiple pregnancy (category 8), and preterm labour (category 10). A gradual fall in caesarean section rate from 14.4% to 10.8% was seen in primiparous women with term spontaneous labour (category 1). Statistically significant differences (Psection rate may be associated with clinical management policies that allow women with relative risk factors (such as breech, previous caesarean section, or multiple pregnancy) to opt for caesarean section. This rise was counterbalanced by a decrease in primary caesarean section rate in primiparous women with spontaneous labour. The trend for caesarean section was more in line with patient expectations rather than evidence-based practice.

  20. Rapid ice unloading in the Fleming Glacier region, southern Antarctic Peninsula, and its effect on bedrock uplift rates

    Science.gov (United States)

    Zhao, Chen; King, Matt A.; Watson, Christopher S.; Barletta, Valentina R.; Bordoni, Andrea; Dell, Matthew; Whitehouse, Pippa L.

    2017-09-01

    Rapid regional warming in the Antarctic Peninsula has led to the significant retreat and eventual collapse of several major ice shelves since the 1970s, triggering the subsequent acceleration and thinning of their feeding glaciers. The Wordie Ice Shelf, lying off the west coast of the Antarctic Peninsula, has undergone long-term disintegration since the 1960s with a substantial calving event occurring around 1989, followed by continuous steady retreat and its almost-complete disappearance. The dynamic response of the upstream glaciers to the ice shelf collapse and the response of the solid Earth to the associated mass loss are not fully understood. To quantify the mass loss from the system, we generated a digital elevation model (DEM) using airborne vertical and oblique imagery from 1966 and compared it to a DEM derived from 2008 SPOT data. This analysis reveals lowering over that time of approximately 60 m at the front of Fleming Glacier. Using IceBridge and ICESat-2/GLAS data spanning 2002-2014, we show an increased rate of mean ice-surface lowering, with rates post-2008 more than twice those of 2002-2008. We use these load change data as a basis for the simulation of viscoelastic solid Earth deformation. We subtract modeled elastic deformation rates, and a suite of modeled viscous rates, from GPS-derived three-dimensional bedrock velocities at sites to the south of Fleming Glacier to infer properties of Earth rheology. Assuming the pre-breakup bedrock uplift was positive due to post-Last Glacial Maximum (LGM) ice retreat, our viscoelastic-corrected GPS uplift rates suggest upper mantle viscosities are > 2 ×1019 Pas and likely > 1 ×1020 Pas in this region, 1-2 orders of magnitude greater than previously found for the northern Antarctic Peninsula. Horizontal velocities at the GPS site nearest the Fleming Glacier, after the application of elastic and plate tectonic corrections, point away from Marguerite Bay rather than the present glacier front. This suggests

  1. Description, evaluation and clinical decision making according to various fetal heart rate patterns. Inter-observer and regional variability

    DEFF Research Database (Denmark)

    Lidegaard, O; Bøttcher, L M; Weber, Tom

    1992-01-01

    departments, especially between departments far apart. It is concluded that we still need a scientific clarification of which specific heart rate changes are the best predictors of fetal stress. Artificial intelligence programs for interpreting fetal cardiotocograms and ECG signals constitute one promising......At 10 Danish obstetrical departments, 116 residents (42 senior and 74 junior) participated in a study to assess inter-observer and regional variability in the description and evaluation of and clinical decision regarding 11 fetal heart rate patterns. The 11 traces included normal as well...... as pathological patterns, and normal as well as clinically asphyxiated babies. Five antepartum and six intrapartum patterns were included. A total of 1,276 descriptions and evaluations were obtained. The degree of agreement in description of fetal heart rate changes was high regarding the baseline...

  2. Description, evaluation and clinical decision making according to various fetal heart rate patterns. Inter-observer and regional variability

    DEFF Research Database (Denmark)

    1992-01-01

    departments, especially between departments far apart. It is concluded that we still need a scientific clarification of which specific heart rate changes are the best predictors of fetal stress. Artificial intelligence programs for interpreting fetal cardiotocograms and ECG signals constitute one promising......At 10 Danish obstetrical departments, 116 residents (42 senior and 74 junior) participated in a study to assess inter-observer and regional variability in the description and evaluation of and clinical decision regarding 11 fetal heart rate patterns. The 11 traces included normal as well...... as pathological patterns, and normal as well as clinically asphyxiated babies. Five antepartum and six intrapartum patterns were included. A total of 1,276 descriptions and evaluations were obtained. The degree of agreement in description of fetal heart rate changes was high regarding the baseline...

  3. Impact of an acute coronary syndrome pathway in achieving target heart rate and utilization of evidence-based doses of beta-blockers.

    Science.gov (United States)

    Irani, Farzan; Herial, Nabeel; Colyer, William R

    2012-11-01

    Beta-blockers remain a cornerstone of therapy in the management of acute coronary syndrome (ACS). The 2007 American College of Cardiology/American Heart Association unstable angina/non-ST elevation myocardial infarction guideline revisions recommend a target heart rate (HR) of 50-60 beats per minute (bpm). Despite improved trends toward utilization of beta-blockers therapy, beta-blockers continue to be underdosed. Guideline-based tools have been shown to improve adherence to evidence-based therapy in patients with ACS. Implementation of a standardized ACS pathway would lead to titration of beta-blockers to recommended dosages with improved HRs in eligible patients. The ACS clinical protocol was implemented at the University of Toledo Medical Center in May 2007. A retrospective study of 516 patients admitted during a comparable 6-month period, before and after the institution of the protocol, was conducted. The preprotocol and protocol group included 237 and 279 patients, respectively. Patient information extracted from the medical records included age, gender, HR on admission, blood pressure on admission, duration of hospital stay, preadmission use of beta-blocker, type of beta-blocker and dosage, discharge beta-blocker and dosage, peak troponin levels, and therapeutic intervention. A target HR of less than 60 bpm was achieved in 19% of the protocol group, as compared with 6% in the preprotocol group (P metoprolol in the protocol group was noted to be significantly higher (118 vs. 80 mg/d; P < 0.001). The institution of an ACS clinical pathway led to utilization of beta-blockers in significantly higher dosages, resulting in improved HR control and increased attainment of target HR.

  4. High rate of unrecognized dengue virus infection in parts of the rainforest region of Nigeria.

    Science.gov (United States)

    Onoja, A B; Adeniji, J A; Olaleye, O D

    2016-08-01

    Outbreaks and sporadic dengue virus infections continue to occur in Africa. Several reports of dengue among travellers returning from some African countries to Europe and North America have raised concerns about the epidemiological situation in Africa. We investigated recent dengue infections in febrile patients during the rainy season in various urban centres in the rainforest region of Nigeria, West Africa. This cross-sectional study was conducted for 8 months in 2014 with study participants from Adeoyo Hospital Yemetu - Ibadan, Nigeria. Plasma were collected from 274 febrile patients residing in 11 Local Government Areas of Oyo State. IgM antibodies were determined using semi-quantitative sandwich ELISA. Data was analyzed using Chi - Square and Fisher's exact test with SPSS 16.0. An overall prevalence of 23.4% dengue virus infection was found among study participants. Highest monthly prevalence of 40% was in April and August. The monthly distribution pattern of dengue virus infection indicates efficient virus transmission. Routine diagnosis will enhance dengue virus surveillance and improve patient care in West Africa.

  5. The analysis of a case rate a skin melanoma in the Samara region for 1999-2009

    Directory of Open Access Journals (Sweden)

    Kozlov S.V.

    2011-06-01

    Full Text Available In article one of oncology problems — a skin melanoma is surveyed. The theme urgency proves to be true that annually the case rate of patients with an oncologic pathology is constantly enlarged. One of oncology problems still has a skin melanoma. The work purpose is studying of a case rate by a skin melanoma in large industrial area on an example of the Samara region over the last 10 years. In article one of oncology problems — a skin melanoma is surveyed. For the task in view decision following materials and methods were used: primary registration documentation for 11 years (1999-2009 About for the first time taped disease a skin melanoma, annual reports of the Samara regional clinical oncologic dispensary, annual statistical reports of the State statistical committee, bureau MSE annual reports. At processing and the forecast of results of research following statistical methods — an extrapolation method, model of linear regress were used. Reliability of the taped pattern of dynamics was defined by means of an error of regress with the subsequent definition t and p. The received results testify to growth of a case rate of all population of the Samara region at the expense of the senior age groups. According to the analysis the invalid population is more often is ill. Conclusions are drawn on appreciable influence on occurrence of this pathology occurring in an organism involutes processes, necessity of carrying out of sanitary-educational work, carrying out of additional profound inspection among the population with high level of a case rate

  6. An alternative method for the estimation of sedimentation rates using radiometric measurements in an intertidal region (sw of spain)

    Science.gov (United States)

    Ligero, Rufino; Casas-Ruiz, Melquiades; Barrera, Manuel; Barbero, Luis

    2010-05-01

    The techniques for the direct measurement of the sedimentation rate are reliable but slow and imprecise, given that the time intervals of measurement cannot be very long. Consequently it is an extremely laborious task to obtain a representative map of the sedimentation rates and such maps are available for very few zones. However, for most environmental studies, it is very important to know the sedimentation rates. The high degree of accuracy of the gamma spectrometric techniques together with the application of the model describes in this work, has allowed the determination of the sedimentation rates in a wide spatial area such of the Bay of Cadiz to be obtained with precision and consuming considerably less time in comparison to the traditional techniques. Even so, the experimental conditions required for the sample cores are fairly restrictive, and although the radiological method provides a quantitative advance in measurement, the experimental difficulty in the execution of the study is not greatly diminished. For this reason, a second model has been derived based on the measurement of the inventory, which offers economies in time and financial cost, and which allows the sedimentation rate in a region to be determined with satisfactory accuracy. Furthermore, it has been shown that the application of this model requires a precise determination of 137Cs inventories. The sedimentation rates estimated by the 137Cs inventory method ranged from 0.26 cm/year to 1.72 cm/year. The average value of the sedimentation rate obtained is 0.59 cm/year, and this rate has been compared with those resulting from the application of the 210Pb dating technique. A good agreement between the two procedures has been found. From the study carried out, it has been possible for the first time, to draw a map of sedimentation rates for this zone where numerous physical-chemical, oceanographic and ecological studies converge, since it is situated in a region of great environmental interest

  7. Quality ratings of frequency-compressed speech by participants with extensive high-frequency dead regions in the cochlea.

    Science.gov (United States)

    Salorio-Corbetto, Marina; Baer, Thomas; Moore, Brian C J

    2017-02-01

    The objective was to assess the degradation of speech sound quality produced by frequency compression for listeners with extensive high-frequency dead regions (DRs). Quality ratings were obtained using values of the starting frequency (Sf) of the frequency compression both below and above the estimated edge frequency, fe, of each DR. Thus, the value of Sf often fell below the lowest value currently used in clinical practice. Several compression ratios were used for each value of Sf. Stimuli were sentences processed via a prototype hearing aid based on Phonak Exélia Art P. Five participants (eight ears) with extensive high-frequency DRs were tested. Reductions of sound-quality produced by frequency compression were small to moderate. Ratings decreased significantly with decreasing Sf and increasing CR. The mean ratings were lowest for the lowest Sf and highest CR. Ratings varied across participants, with one participant rating frequency compression lower than no frequency compression even when Sf was above fe. Frequency compression degraded sound quality somewhat for this small group of participants with extensive high-frequency DRs. The degradation was greater for lower values of Sf relative to fe, and for greater values of CR. Results varied across participants.

  8. Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Eric Westman

    Full Text Available BACKGROUND: Visual assessment rating scales for medial temporal lobe (MTL atrophy have been used by neuroradiologists in clinical practice to aid the diagnosis of Alzheimer's disease (AD. Recently multivariate classification methods for magnetic resonance imaging (MRI data have been suggested as alternative tools. If computerized methods are to be implemented in clinical practice they need to be as good as, or better than experienced neuroradiologists and carefully validated. The aims of this study were: (1 To compare the ability of MTL atrophy visual assessment rating scales, a multivariate MRI classification method and manually measured hippocampal volumes to distinguish between subjects with AD and healthy elderly controls (CTL. (2 To assess how well the three techniques perform when predicting future conversion from mild cognitive impairment (MCI to AD. METHODS: High resolution sagittal 3D T1w MP-RAGE datasets were acquired from 75 AD patients, 101 subjects with MCI and 81 CTL from the multi-centre AddNeuroMed study. An automated analysis method was used to generate regional volume and regional cortical thickness measures, providing 57 variables for multivariate analysis (orthogonal partial least squares to latent structures using seven-fold cross-validation. Manual hippocampal measurements were also determined for each subject. Visual rating assessment of MTL atrophy was performed by an experienced neuroradiologist according to the approach of Scheltens et al. RESULTS: We found prediction accuracies for distinguishing between AD and CTL of 83% for multivariate classification, 81% for the visual rating assessments and 89% for manual measurements of total hippocampal volume. The three different techniques showed similar accuracy in predicting conversion from MCI to AD at one year follow-up. CONCLUSION: Visual rating assessment of the MTL gave similar prediction accuracy to multivariate classification and manual hippocampal volumes. This

  9. Volatile organic compounds from vegetation in southern Yunnan Province, China: Emission rates and some potential regional implications

    Science.gov (United States)

    Geron, Chris; Owen, Sue; Guenther, Alex; Greenberg, Jim; Rasmussen, Rei; Hui Bai, Jian; Li, Qing-Jun; Baker, Brad

    Little information is currently available regarding emissions of biogenic volatile organic compounds (BVOCs) in southern Asia. To address the need for BVOC emission estimates in regional atmospheric chemistry simulations, 95 common plant species were screened for emissions of BVOC in and near the Xishuangbanna Tropical Biological Gardens in southern Yunnan Province, Peoples' Republic of China in February 2003. In situ measurements with leaf cuvettes and branch bag enclosures were used in combination with portable gas chromatography, flame ionization, photoionization, and mass spectral detection to identify and quantify BVOC emissions. Forty-four of the species examined emitted isoprene at rates exceeding 20 μg C g -1 (leaf dry weight) h -1. An emphasis was placed on the genus Ficus, which is important in the region and occupies a wide range of ecological niches. Several species in the footprint of a nearby flux tower were also examined. Several palm species and an abundant fern ( Cyclosorus parasiticus) emitted substantial amounts of isoprene, and probably accounted for observed daytime mean isoprene fluxes from the understory of a Hevea brasiliensis plantation of 1.0 and 0.15 mg C m -2 h -1 during the wet and dry seasons, respectively. These measurements verify that both the forest floor and canopy in this region can be sources of isoprene. Monoterpene emissions exceeded 1.0 μg-C g -1 (leaf dry weight) h -1 from only 4 of 38 species surveyed, including some Ficus species and H. brasiliensis. However most of the trees of the latter species were sparsely foliated due to dry season senescence, and emission factors are approximately an order of magnitude lower than those reported during the wet season. BVOC emission rates and physiology of many species are impacted by reduced moisture availability, especially Mangifera indica. South Asia is a region undergoing rapid landuse change and forest plantation establishment, with large increases in area of high BVOC

  10. Induction of chromosome aberrations is non-linear within the low dose region and depends on dose rate

    Energy Technology Data Exchange (ETDEWEB)

    Oudalova, A.A.; Geras' kin, S.A.; Dikarev, V.G.; Nesterov, Y.B.; Dikareva, N.S

    2002-07-01

    The low dose region was evaluated for meristem cells of spring barley. A study of the cytogenetic damage in the low dose range was carried out to determine the genuine shape of the dose curve. The relationship between the frequency of aberrant cells and the absorbed dose is shown to be non-linear with a site at low doses within which the cytogenetic damage exceeds the control level significantly and does not depend on dose value. Within the tested exposure region, the aberrant cell frequency is found to decrease with increasing dose rate, but the shape of the dose curve remained invariable. The piecewise linear model fits the experimental data much better than the linear one. (author)

  11. GPS-constrained inversion of present-day slip rates along major faults of the Sichuan-Yunnan region, China

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A linked-fault-element model is employed to invert for contemporary slip rates along major active faults in the Sichuan-Yunnan region (96°-108°E, 21°-35°N) using the least squares method. The model is based on known fault geometry, and constrained by a GPS-derived horizontal velocity field. Our results support a model attributing the eastward extrusion of the Tibetan Plateau driven mainly by the north-northeastward indentation of the Indian plate into Tibet and the gravitational collapse of the plateau. Resisted by a relatively stable south China block, materials of the Sichuan-Yunnan region rotate clockwise around the eastern Himalayan tectonic syntaxis. During the process the Garzê-Yushu, Xianshuihe, Anninghe, Zemuhe, Daliangshan, and Xiaojiang faults, the southwest extension of the Xiaojiang fault, and the Daluo-Jinghong and Mae Chan faults constitute the northeast and east boundaries of the eastward extrusion, with their left slip rates being 0.3-14.7, 8.9-17.1, 5.1 ± 2.5, 2.8 ± 2.3, 7.1 ± 2.1, 9.4 ± 1.2, 10.1 ± 2.0, 7.3 ± 2.6, and 4.9 ± 3.0 mm/a respectively. The southwestern boundary consists of a widely distributed dextral transpressional zone other than a single fault. Right slip rates of 4.2 ± 1.3, 4.3 ± 1.1, and 8.5 ± 1.7 mm/a are detected across the Nanhua-Chuxiong-Jianshui, Wuliangshan, and Longling-Lancang faults. Crustal deformation across the Longmenshan fault is weak, with short-ening rates of 1.4 ± 1.0 and 1.6 ± 1.3 mm/a across the Baoxing-Beichuan and Beichuan-Qingchuan segments. Northwest of the Longmenshan fault lies an active deformation zone (the Longriba fault) with 5.1±1.2 mm/a right slip across. Relatively large slip rates are detected across a few faults within the Sichuan-Yunnan block: 4.4±1.3 mm/a left slip and 2.7±1.1 mm/a shortening across the Litang fault, and 2.7±2.3 mm/a right-lateral shearing and 6.7±2.3 mm/a shortening across the Yunongxi fault and its surrounding regions. In conclusion, we find that the

  12. GPS-constrained inversion of present-day slip rates along major faults of the Sichuan-Yunnan region, China

    Institute of Scientific and Technical Information of China (English)

    WANG YanZhao; YANG YongLin; CHENG Jia; LI Peng; WANG EnNing; SHEN ZhengKang; WANG Min; GAN WeiJun; QIAO XueJun; MENG GuoJie; LI TieMing; TAO Wei

    2008-01-01

    A linked-fault-element model is employed to invert for contemporary slip rates along major active faults in the Sichuan-Yunnan region (96°-108°E, 21°-35°N) using the least squares method.The model is based on known fault geometry, and constrained by a GPS-derived horizontal velocity field.Our results support a model attributing the eastward extrusion of the Tibetan Plateau driven mainly by the north-northeastward indentation of the Indian plate into Tibet and the gravitational collapse of the plateau.Resisted by a relatively stable south China block, materials of the Sichuan-Yunnan region rotate clockwise around the eastern Himalayan tectonic syntaxis.During the process the Garze-Yushu, Xianshuihe, Anninghe, Zemuhe, Daliangshan, and Xiaojiang faults, the southwest extension of the Xiaojiang fault, and the Daluo-Jinghong and Mae Chan faults constitute the northeast and east boundaries of the eastward extrusion, with their left slip rates being 0.3-14.7, 8.9-17.1, 5.1 ±2.5, 2.8± 2.3, 7.1 ±2.1, 9.4 ±1.2, 10.1 ±2.0, 7.3 ±2.6, and 4.9 ±3.0 mm/a respectively.The southwestern boundary consists of a widely distributed dextral transpressional zone other than a single fault.Right slip rates of 4.2 ±1.3, 4.3 ±1.1, and 8.5 ±1.7 mm/a are detected across the Nanhua-Chuxiong-Jianshui, Wuliangshan, and Longling-Lancang faults.Crustal deformation across the Longmenshan fault is weak, with shortening rates of 1.4 ±1.0 and 1.6 ±1.3 mm/a across the Baoxing-Beichuan and Beichuan-Qingchuan segments.Northwest of the Longmenshan fault lies an active deformation zone (the Longriba fault) with 5.1 ±1.2 mm/a right slip across.Relatively large slip rates are detected across a few faults within the Sichuan-Yunnan block: 4.4±1.3 mm/a left slip and 2.7±1.1 mm/a shortening across the Litang fault, and 2.7±2.3 mm/a right-lateral shearing and 6.7±2.3 mm/a shortening across the Yunongxi fault and its surrounding regions.In conclusion, we find that the Sichuan-Yunnan region is

  13. Investigating the variations in survival rates for very preterm infants in ten European regions: the MOSAIC birth cohort

    DEFF Research Database (Denmark)

    2008-01-01

    for NIC. For babies babies alive at onset of labour were admitted to neonatal intensive care. CONCLUSIONS: There are wide variations in the survival rates to discharge from NIC for very preterm deliveries and in the timing of death across the MOSAIC regions. In order......: All deliveries from 22+0 to 31+6 weeks gestation. MAIN OUTCOME MEASURE: All outcomes of pregnancy by gestational age group, including termination of pregnancy for congenital anomalies and other reasons, ante-partum stillbirth, intra-partum stillbirth, labour ward death, death after admission...

  14. Measuring the prevalence of regional mutation rates: an analysis of silent substitutions in mammals, fungi, and insects

    Directory of Open Access Journals (Sweden)

    Tuch Brian B

    2008-06-01

    Full Text Available Abstract Background The patterns of mutation vary both within and across genomes. It has been shown for a few mammals that mutation rates vary within the genome, while for unknown reasons, the sensu stricto yeasts have uniform rates instead. The generality of these observations has been unknown. Here we examine silent site substitutions in a more expansive set (20 mammals, 27 fungi, 4 insects to determine why some genomes demonstrate this mosaic distribution and why others are uniform. Results We applied several intragene and intergene correlation tests to measure regional substitution patterns. Assuming that silent sites are a reasonable approximation to neutrally mutating sequence, our results show that all multicellular eukaryotes exhibit mutational heterogeneity. In striking contrast, all fungi are mutationally uniform – with the exception of three Candida species: C. albicans, C. dubliniensis, and C. tropicalis. We speculate that aspects of replication timing may be responsible for distinguishing these species. Our analysis also reveals classes of genes whose silent sites behave anomalously with respect to the mutational background in many species, indicating prevalent selective pressures. Genes associated with nucleotide binding or gene regulation have consistently low silent substitution rates in every mammalian species, as well as multiple fungi. On the other hand, receptor genes repeatedly exhibit high silent substitution rates, suggesting they have been influenced by diversifying selection. Conclusion Our findings provide a framework for understanding the regional mutational properties of eukaryotes, revealing a sharp difference between fungi and multicellular species. They also elucidate common selective pressures acting on eukaryotic silent sites, with frequent evidence for both purifying and diversifying selection.

  15. Role of heart rate in the relation between regional body fat and subendocardial viability ratio in women.

    Science.gov (United States)

    Gonzales, Joaquin U; Hadri, Omar

    2016-09-01

    Subendocardial viability ratio (SEVR) is a measure of left ventricular function, specifically; it is an index of myocardial perfusion relative to left ventricular workload. Women have lower SEVR than men, partly due to a faster resting heart rate that reduces diastolic time (i.e., time for myocardial perfusion). It is unclear if body fat relates to SEVR, thus the purpose of this study was to examine the relation between body fat and SEVR in women. Twenty-eight middle-aged (31-45 years) and 31 older (60-80 years) women were examined. Radial artery applanation tonometry was used to calculate SEVR from a synthesized central aortic pressure wave. Dual-energy X-ray absorptiometry was used to assess body composition including fat in the trunk, legs, android and gynoid regions. Body fat was not related (P>.05) with SEVR in older women. In middle-aged women, all measures of regional fat were correlated with heart rate (range, r=.49-.59, P≤.01) and SEVR (range, r=.43-.53, P≤.01). Android-to-gynoid ratio was identified as the strongest predictor (r(2) =-.26, Pfat. Middle-aged women with lower android-to-gynoid fat ratio had higher SEVR (1.96±0.33 vs 1.66±0.20, P=.009) than women with higher fat ratio, even after adjusting for age, height, daily physical activity, and aortic mean pressure (P=.02). Adjusting for heart rate or diastolic time abolished the difference in SEVR between groups (1.80±0.09 vs 1.82±0.09, P=.56). These results suggest that middle-aged women with a greater distribution of fat in the abdomen have poorer left ventricular function that is dependent on the negative influence of heart rate on diastolic time.

  16. 210Pb and 137Cs measurements in the Circum Bohai Sea coastal region: sedimentation rates and implications

    Institute of Scientific and Technical Information of China (English)

    Fu WANG; Hong WANG; Jianfen LI; Yandong PEI; Changfu FAN; Lizhu TIAN; Zhiwen SHANG; Meiyu SONG; Yan GENG

    2008-01-01

    The representative 210Pb and 137Cs age-depth profiles were selected from more than 100 sites in the Circum Bohai Sea (CBS)coastal region to examine the sedimentation rates and associated environmental changes.There are three unique 210Pbexc distribution patterns:1)ideal-decaying type,representing relatively constant sediment supply and quieter environmental setting;2)wiggling type,but with approximately equivalent amplitude,representing coarser sediments and associated stronger flow current environment;and 3) episodic-eventinfluencing type,each representing typhoon storm-influenced depositional environment.Our results also show that there is a lower sedimentation rate(ca.0.1 cm/a)in the coastal lowlands,a higher sedimentation rate(ca.0.53 cm/a)in the intertidal flat and an intermediate rate of ca.0.58 cm/a in the subtidal zone near the Huanghua Harbor.The interbedded silt layer occurring in the core sediment reveals lower 210Pb activities,indicating a discontinuous sedimentation mostly due to typhoon events which dwarfs against 210Pb and 137Cs applicability.Overall,the 210Pb and 137Cs measurements of the present study provide physical insight into the evaluation of the coastal-marine ecological environment and associated management.

  17. Role of the Land Valuation Division in Property Rating by District Assemblies in Ghana's Upper East Region

    Directory of Open Access Journals (Sweden)

    Maxwell Kwotua Petio

    2013-05-01

    Full Text Available District Assemblies in Ghana are charged with the responsibility of developing their areas of jurisdiction mainly through internally mobilised revenue. As a consequence, the assemblies are empowered by various pieces of legislation to impose local taxes within their jurisdiction. The local taxes include property rates which are a form of tax that only the District Assemblies may levy. The study therefore looked at the levying of property rates in the Upper East Region and assessed the role and institutional capacity of the Land Valuation Division of the Lands Commission in the tax administration. Findings included limited coverage of the tax, use of flat rates due to absence of up-to-date property values, inadequate technical personnel and logistics for the Land Valuation Division (LVD and lack of political will to levy the rates fully. Relevant suggestions are made, such as the need to introduce mass valuation, widen the tax coverage, establish a fund for revaluation and revive the Valuation Training School, as well as provide requisite logistics for efficient performance of the LVD.

  18. Quantification of Regional Left Ventricular Systolic Dysfunction in Patients With Coronary Artery Disease by Strain Rate Imaging

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    To detect and compare the systolic strain rate (SR) and strain in the infarct and ischemic myocardiu mby strain rate imaging ( SRI), in order to explore the clinical value of SRI in evaluating regional left ventricular systolic dysfunction. Methods Patients with coronary artery disease were divided into angina pectoris ( 11 cases) and myocardial infarction (21 cases) groups. Twenty age-matched normal subjects served as the control group. Septal, lateral, anterior, inferior, anteroseptal and posterior walls of the left ventricle were respectively scanned using color tissue Doppler imaging (TDI). Then SR and strain curves were derived from TDI for basal, middle and apical segments of each wall.SRI parameters were: Systolic SR ( Srsys), systolic strain (εsys) and maximum strain (εmax). Results Compared with normal segments, Srsys, εsys and εmax decreased significantly in the infarct and ischemic segments ( P < 0.01 ). Compared with ischemic segments, Srsys, εsys and εmax decreased significantly in the infarct segments ( P <0.05 ). Conclusions Srsys, εsys and εmax measured by SRI can be used to quantitatively analyze regional left ventricular systolic dysfunction in patients with coronary artery disease, and aid in differentiating infarct from ischemic myocardium.

  19. An AFLP estimation of the outcrossing rate of Spondias tuberosa (Anacardiaceae), an endemic species to the Brazilian semiarid region.

    Science.gov (United States)

    Fernandes Santos, Carlos Antonio; de Souza Gama, Renata Natália Cândido

    2013-06-01

    The umbu tree (Spondias tuberosa) is one of the most important endemic species to the Brazilian tropical semiarid region. The umbu tree has edible fruits with a peculiar flavor that are consumed in natura or in a semi-industrialized form, such as jams, candies and juices. The majority of endemic species to Brazilian semiarid region have not been studied or sampled to form germ-plasm collections, which increases the risk of losing genetic variability of the adapted species to xerophytic conditions. The aim of this study was to estimate outcrossing rates in S. tuberosa using a multilocus mixed model in order to guide genetic resources and breeding programs of this species. DNA samples were extracted from 92 progenies of umbu trees, which were distributed among 12 families. These trees were planted by seed in 1991 in Petrolina, PE, Brazil. The experimental design was a randomized block, with a total of 42 progenies sampled in three regions. The experimental units were composed by five plants and five replications. The outcrossing rate was estimated by the multilocus model, which is available in the MLTR software, and was based on 17 polymorphic AFLP bands obtained from AAA_CTG and AAA_CTC primer combinations. The observed heterozygotes ranged from 0.147 to 0.499, with a maximum frequency estimated for the AAA_CTC 10 amplicon. The multilocus outcrossing estimation (t(m)) was 0.804 +/- 0.072, while the single-locus (t(s)) was 0.841 +/- 0.079, which suggests that S. tuberosa is predominantly an outcrossing species. The difference between t(m) and t(s) was -0.037 +/- 0.029, which indicates that biparental inbreeding was nearly absent. The mean inbreeding coefficient or fixation index (F) among maternal plants was--0.103 +/- 0.045, and the expected F was 0.108, which indicates that there was no excess of heterozygotes in the maternal population. The outcrossing estimates obtained in the present study indicate that S. tuberosa is an open-pollinated species. Biometrical

  20. Insights from Synthetic Star-forming Regions - III. Calibration of Measurement Techniques of Star-formation Rates

    CERN Document Server

    Koepferl, Christine M; Dale, James E

    2016-01-01

    Through an extensive set of realistic synthetic observations (produced in Paper I), we assess in this part of the paper series (Paper III) how the choice of observational techniques affects the measurement of star-formation rates (SFRs) in star-forming regions. We test the accuracy of commonly used techniques and construct new methods to extract the SFR, so that these findings can be applied to measure the SFR in real regions throughout the Milky Way. We investigate diffuse infrared SFR tracers such as those using 24 {\\mu}m, 70 {\\mu}m and total infrared emission, which have been previously calibrated for global galaxy scales. We set up a toy model of a galaxy and show that the infrared emission is consistent with the intrinsic SFR using extra-galactic calibrated laws (although the consistency does not prove their reliability). For local scales, we show that these techniques produce completely unreliable results for single star-forming regions, which are governed by different characteristic timescales. We show...

  1. Study on Relation Between Dynamic Pattern of Regional Vertical Strain Rate and Several Strong Earthquakes such as Lijiang (Ms7. 0) and Menyuan (Ms6.4) Earthquakes

    Institute of Scientific and Technical Information of China (English)

    Wang Shuangxu; Jiang Zaisen; Zhang Xi; Chen Bing

    2000-01-01

    Making use of the method of obtaining regional vertical strain rate from regional preciseleveling data and gaining dynamic pattern combining with deformation data on spanningfaults, the regional vertical strain dynamic evolution characteristics of several moderatelystrong earthquakes such as Lijiang ( Ms 7.0) and Menyuan ( Ms 6.4) earthquakes occurredin crustal deformation monitoring areas located in the western Yunnan and Qilianshan-Hexiregion. Based on the above-mentioned facts, by studying the time-space nonhomogeneity andstrain energy accumulation status, some criteria for judging the medium- and short-termstrong seismic risk regions according to the regional vertical strain rate dynamic informationare proposed.

  2. Evaluation of Regional Myocardial Systolic Function in the Early Stage of Acute Myocardial Infarction by Strain Rate Imaging

    Directory of Open Access Journals (Sweden)

    M Esmaeilzadeh

    2009-12-01

    Full Text Available Background: We sought to evaluate the impact of different therapeutic strategies on longitudinal regional myocardial systolic function in the early phase of acute myocardial infarction using strain rate imaging.Methods: A total of 38 patients (34 males, with first acute myocardial infarction (AMI were evaluated. Our patients were divided into 3 groups according to the kind of therapy. The mean age of the patients was 55 ± 9.4 years (range: 39- 75 years. Mean left ventricular ejection fraction (LVEF in the patients was 41 ± 10.7%. Primary percutaneous coronary intervention (PCI was performed in 10 patients. Sixteen patients were treated by thrombolytic therapy using streptokinase (SK and 12 were followed-up conservatively. All patients underwent a comprehensive echocardiography study including SR imaging within 3- 5 days after AMI. The parameters measured included peak systolic strain (peakε and strain rate (SRs, end-systolic strain (εes, post systolic shortening (PSS, time to peak systolic strain rate (tSRs, time to end of shortening (teSRs, post systolic strain (PSε, post-systolic strain index (PSI, PSS ratio (PSS/ εMax and peak postsystolic strain rate (SRPSS. Results: There was not any association either between WMSI and tå (P=0.4, or MI location and PSS ratio (P=0.13. But there was an inverse relationship between WMSI and mean SRS, especially when WMSI was more pronounced. A significant relationship was found between tε and teSRs with the kind of therapy (shorter in PCI group (P= 0.04. Using a simple linear regression model, no association was found between PSS ratio and SRs (â=0.056, P =0.70, PSI and teSRs (β= -0.772, P=0.12. Simple linear regression model showed a weak but significant relationship between PSI and Median tε (β = -0.851, P =0.04; r =0.33.Conclusion: Our study showed that PCI resulted in early recovery of regional systolic function of infarcted myocardium during the early stage of acute myocardial infarction.

  3. Economic optimal nitrogen application rates for rice cropping in the Taihu Lake region of China: taking account of negative externalities

    Directory of Open Access Journals (Sweden)

    Y. Xia

    2011-07-01

    Full Text Available Nitrogen application rates (NARs is often overestimated over the rice (Oryza sativa L. growing season in the Taihu Lake region of China. This is largely because only individual nitrogen (N losses are taken into account, or the inventory flows of reactive N have been limited solely to the farming process when evaluating environmental and economic effects of N fertilizer. Since N can permeate the ecosystem in numerous forms commencing from the acquisition of raw material, through manufacturing and use, to final losses in the farming process (e.g., N2O, NH3, NO3 leaching, etc., the costs incurred also accumulate and should be taken into account if economically-optimal N rates (EONRs are to be established. This study integrates important material and energy flows resulting from N use into a rice agricultural inventory that constitutes the hub of the life-cycle assessment (LCA method. An economic evaluation is used to determine an environmental and economic NAR for the Taihu Lake region. The analysis reveals that production and exploitation processes consume the largest proportion of resources, accounting for 77.2 % and 22.3 % of total resources, respectively. Regarding environmental impact, global warming creates the highest cost with contributions stemming mostly from fertilizer production and raw material exploitation processes. Farming process incurs the biggest environmental impact of the three environmental impact categories considered, whereas transportation has a much smaller effect. When taking account of resource consumption and environmental cost, the marginal benefit of 1 kg rice would decrease from 2.4 to only 1.01 yuan. Accordingly, our current EONR has been evaluated at 185 kg N ha−1 for a single rice-growing season. This could enhance profitability, as well as reduce the N losses associated with rice growing.

  4. CH(+) Destruction by Reaction with H: Computing Quantum Rates To Model Different Molecular Regions in the Interstellar Medium.

    Science.gov (United States)

    Bovino, S; Grassi, T; Gianturco, F A

    2015-12-17

    A detailed analysis of an ionic reaction that plays a crucial role in the carbon chemistry of the interstellar medium (ISM) is carried out by computing ab initio reactive cross sections with a quantum method and by further obtaining the corresponding CH(+) destruction rates over a range of temperatures that shows good overall agreement with existing experiments. The differences found between all existing calculations and the very-low-T experiments are discussed and explored via a simple numerical model that links these cross section reductions to collinear approaches where nonadiabatic crossing is expected to dominate. The new rates are further linked to a complex chemical network that models the evolution of the CH(+) abundance in the photodissociation region (PDR) and molecular cloud (MC) environments of the ISM. The abundances of CH(+) are given by numerical solutions of a large set of coupled, first-order kinetics equations that employs our new chemical package krome. The analysis that we carry out reveals that the important region for CH(+) destruction is that above 100 K, hence showing that, at least for this reaction, the differences with the existing laboratory low-T experiments are of essentially no importance within the astrochemical environments discussed here because, at those temperatures, other chemical processes involving the title molecule are taking over. A detailed analysis of the chemical network involving CH(+) also shows that a slight decrease in the initial oxygen abundance might lead to higher CH(+) abundances because the main chemical carbon ion destruction channel is reduced in efficiency. This might provide an alternative chemical route to understand the reason why general astrochemical models fail when the observed CH(+) abundances are matched with the outcomes of their calculations.

  5. Geothermal flux and basal melt rate in the Dome C region inferred from radar reflectivity and heat modelling

    Directory of Open Access Journals (Sweden)

    O. Passalacqua

    2017-09-01

    Full Text Available Basal melt rate is the most important physical quantity to be evaluated when looking for an old-ice drilling site, and it depends to a great extent on the geothermal flux (GF, which is poorly known under the East Antarctic ice sheet. Given that wet bedrock has higher reflectivity than dry bedrock, the wetness of the ice–bed interface can be assessed using radar echoes from the bedrock. But, since basal conditions depend on heat transfer forced by climate but lagged by the thick ice, the basal ice may currently be frozen whereas in the past it was generally melting. For that reason, the risk of bias between present and past conditions has to be evaluated. The objective of this study is to assess which locations in the Dome C area could have been protected from basal melting at any time in the past, which requires evaluating GF. We used an inverse approach to retrieve GF from radar-inferred distribution of wet and dry beds. A 1-D heat model is run over the last 800 ka to constrain the value of GF by assessing a critical ice thickness, i.e. the minimum ice thickness that would allow the present local distribution of basal melting. A regional map of the GF was then inferred over a 80 km  ×  130 km area, with a N–S gradient and with values ranging from 48 to 60 mW m−2. The forward model was then emulated by a polynomial function to compute a time-averaged value of the spatially variable basal melt rate over the region. Three main subregions appear to be free of basal melting, two because of a thin overlying ice and one, north of Dome C, because of a low GF.

  6. Geothermal flux and basal melt rate in the Dome C region inferred from radar reflectivity and heat modelling

    Science.gov (United States)

    Passalacqua, Olivier; Ritz, Catherine; Parrenin, Frédéric; Urbini, Stefano; Frezzotti, Massimo

    2017-09-01

    Basal melt rate is the most important physical quantity to be evaluated when looking for an old-ice drilling site, and it depends to a great extent on the geothermal flux (GF), which is poorly known under the East Antarctic ice sheet. Given that wet bedrock has higher reflectivity than dry bedrock, the wetness of the ice-bed interface can be assessed using radar echoes from the bedrock. But, since basal conditions depend on heat transfer forced by climate but lagged by the thick ice, the basal ice may currently be frozen whereas in the past it was generally melting. For that reason, the risk of bias between present and past conditions has to be evaluated. The objective of this study is to assess which locations in the Dome C area could have been protected from basal melting at any time in the past, which requires evaluating GF. We used an inverse approach to retrieve GF from radar-inferred distribution of wet and dry beds. A 1-D heat model is run over the last 800 ka to constrain the value of GF by assessing a critical ice thickness, i.e. the minimum ice thickness that would allow the present local distribution of basal melting. A regional map of the GF was then inferred over a 80 km × 130 km area, with a N-S gradient and with values ranging from 48 to 60 mW m-2. The forward model was then emulated by a polynomial function to compute a time-averaged value of the spatially variable basal melt rate over the region. Three main subregions appear to be free of basal melting, two because of a thin overlying ice and one, north of Dome C, because of a low GF.

  7. Data from theodolite measurements of creep rates on San Francisco Bay region faults, California: 1979-2001

    Science.gov (United States)

    Galehouse, Jon S.

    2002-01-01

    My purpose is to make our creep data on San Francisco Bay region active faults available to the scientific research community. My student research assistants and I measured creep (aseismic slip) rates on these faults from 1979 until my retirement from the project in 2001. These data are further described in my final technical report as principal investigator, which summarizes results from 22 September 1979 through 28 February 2001 (Galehouse, 2001). We made over 2,600 creep measurements, about one-third in the ten years prior to the Loma Prieta earthquake (LPEQ) and two-thirds in the 11.4 years following it. The measurements are continuing to be made by members of the Geosciences Department at San Francisco State University (SFSU) under the direction of Karen Grove and John Caskey. A complete analysis of our results obtained on the Hayward fault is presented in Lienkaemper, Galehouse, and Simpson (2001). A formal report based on the entire San Francisco Bay region data set is in preparation. Data sheets for each site along the fault are available for downloading in Excel format to facilitate analysis of the data. They are also available as tab-delimited raw data. The data include all regular measurement sites, SF–1 through SF–34, and the 20 SFSU and U.S. Geological Survey (USGS) afterslip sites on the Hayward fault.

  8. Achievement and High School Completion Rates of Hispanic Students with No English Language Skills Compared to Hispanic Students with Some English Language Skills Attending the Same High School in an Immigrant Responsive City

    Science.gov (United States)

    Garrison, Joanne M.

    2012-01-01

    The purpose of the study was to determine achievement and high school completion rates of Hispanic students (n = 13) with no English language skills compared to Hispanic students (n = 11) with some English language skills attending the same high school in an immigrant responsive city. All students were in attendance in the research school…

  9. Utilizing Joint Routing and Capacity Assignment Algorithms to Achieve Inter- and Intra-Group Delay Fairness in Multi-Rate Multicast Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Yean-Fu Wen

    2013-03-01

    Full Text Available Recent advance in wireless sensor network (WSN applications such as the Internet of Things (IoT have attracted a lot of attention. Sensor nodes have to monitor and cooperatively pass their data, such as temperature, sound, pressure, etc. through the network under constrained physical or environmental conditions. The Quality of Service (QoS is very sensitive to network delays. When resources are constrained and when the number of receivers increases rapidly, how the sensor network can provide good QoS (measured as end-to-end delay becomes a very critical problem. In this paper; a solution to the wireless sensor network multicasting problem is proposed in which a mathematical model that provides services to accommodate delay fairness for each subscriber is constructed. Granting equal consideration to both network link capacity assignment and routing strategies for each multicast group guarantees the intra-group and inter-group delay fairness of end-to-end delay. Minimizing delay and achieving fairness is ultimately achieved through the Lagrangean Relaxation method and Subgradient Optimization Technique. Test results indicate that the new system runs with greater effectiveness and efficiency.

  10. Utilizing joint routing and capacity assignment algorithms to achieve inter- and intra-group delay fairness in multi-rate multicast wireless sensor networks.

    Science.gov (United States)

    Lin, Frank Yeong-Sung; Hsiao, Chiu-Han; Lin, Leo Shih-Chang; Wen, Yean-Fu

    2013-03-14

    Recent advance in wireless sensor network (WSN) applications such as the Internet of Things (IoT) have attracted a lot of attention. Sensor nodes have to monitor and cooperatively pass their data, such as temperature, sound, pressure, etc. through the network under constrained physical or environmental conditions. The Quality of Service (QoS) is very sensitive to network delays. When resources are constrained and when the number of receivers increases rapidly, how the sensor network can provide good QoS (measured as end-to-end delay) becomes a very critical problem. In this paper; a solution to the wireless sensor network multicasting problem is proposed in which a mathematical model that provides services to accommodate delay fairness for each subscriber is constructed. Granting equal consideration to both network link capacity assignment and routing strategies for each multicast group guarantees the intra-group and inter-group delay fairness of end-to-end delay. Minimizing delay and achieving fairness is ultimately achieved through the Lagrangean Relaxation method and Subgradient Optimization Technique. Test results indicate that the new system runs with greater effectiveness and efficiency.

  11. Utilizing Joint Routing and Capacity Assignment Algorithms to Achieve Inter- and Intra-Group Delay Fairness in Multi-Rate Multicast Wireless Sensor Networks

    Science.gov (United States)

    Lin, Frank Yeong-Sung; Hsiao, Chiu-Han; Lin, Leo Shih-Chang; Wen, Yean-Fu

    2013-01-01

    Recent advance in wireless sensor network (WSN) applications such as the Internet of Things (IoT) have attracted a lot of attention. Sensor nodes have to monitor and cooperatively pass their data, such as temperature, sound, pressure, etc. through the network under constrained physical or environmental conditions. The Quality of Service (QoS) is very sensitive to network delays. When resources are constrained and when the number of receivers increases rapidly, how the sensor network can provide good QoS (measured as end-to-end delay) becomes a very critical problem. In this paper; a solution to the wireless sensor network multicasting problem is proposed in which a mathematical model that provides services to accommodate delay fairness for each subscriber is constructed. Granting equal consideration to both network link capacity assignment and routing strategies for each multicast group guarantees the intra-group and inter-group delay fairness of end-to-end delay. Minimizing delay and achieving fairness is ultimately achieved through the Lagrangean Relaxation method and Subgradient Optimization Technique. Test results indicate that the new system runs with greater effectiveness and efficiency. PMID:23493123

  12. Energy savings and higher volumetric loading rate achieved in the conventional anoxic-oxic process for sewage treatment by enhancing biomass retention in the secondary clarifier.

    Science.gov (United States)

    Zhang, Xueyu; Liu, Fengyuan; Zheng, Shaokui

    2017-06-01

    This is the first study to achieve a short HRT (∼2h for the A/O reactor), high MLSS (∼10gL(-1)), and high volumetric loading (∼3.7kg CODm(-3)d(-1) and ∼0.6kg NH4-Nm(-3)d(-1)) in the A/O process for sewage treatment by enhancing biomass retention in the secondary clarifier (∼4h settling time), which we refer to as the high-performance A/O process (HP-A/O) in this paper. Over 258days of continuous operation, with a decrease in HRT from 12 to 2h, remarkable COD (95±3%), NH4(+)-N (98±2%), TN (79±5%), and TP (74±10%) removals were stably achieved, while the air requirement significantly decreased by 22%. The HP-A/O process offers advantages over the conventional A/O process (6-8h for A/O reactor, 3-5gL(-1)MLSS, and ∼1.0kg CODm(-3)d(-1)) for sewage treatment in terms of its lower energy consumption, smaller footprint and reactor requirements. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. The Impact of Low, Moderate, and High Military Family Mobility School District Transfer Rates on Graduating Senior High School Dependents' Achievement and School Engagement

    Science.gov (United States)

    Rippe, Jeffrey K.

    2012-01-01

    The results of this study suggest that there were no significant differences in the academic performance of military dependents' with low (n = 20), moderate (n = 20), and high (n = 20) mobility school district transfer rates compared to non-military control students (n = 20) before completing high school. The findings were not consistent with…

  14. Measures of Heart Rate Variability and How They Relate to Age, Gender, Emotional Behavior, and Academic Achievement in Elementary School Children in Adventist and Public Schools

    Science.gov (United States)

    Dalton, Marilee Serns

    2013-01-01

    The analysis of heart rate variability (HRV) is one tool shown to be of value in examining heart-brain interactions. HRV is remarkably responsive to emotion, and the importance of emotional state in cognitive function is increasingly being recognized and socio-emotional learning strategies being utilized in the classroom. Consequently, the…

  15. Using First-Grade Teacher Ratings to Predict Third-Grade English Language Arts and Mathematics Achievement on a High-Stakes Statewide Assessment

    Science.gov (United States)

    Gallant, Dorinda J.

    2013-01-01

    Early childhood professional organizations support teachers as the best assessors of students' academic, social, emotional, and physical development. This study investigates the predictive nature of teacher ratings of first-grade students' performance on a standards-based curriculum-embedded performance assessment within the context of a state…

  16. Measures of Heart Rate Variability and How They Relate to Age, Gender, Emotional Behavior, and Academic Achievement in Elementary School Children in Adventist and Public Schools

    Science.gov (United States)

    Dalton, Marilee Serns

    2013-01-01

    The analysis of heart rate variability (HRV) is one tool shown to be of value in examining heart-brain interactions. HRV is remarkably responsive to emotion, and the importance of emotional state in cognitive function is increasingly being recognized and socio-emotional learning strategies being utilized in the classroom. Consequently, the…

  17. Effects of the Connected Mathematics Project 2 (CMP2) on the Mathematics Achievement of Grade 6 Students in the Mid-Atlantic Region. Final Report. NCEE 2012-4017

    Science.gov (United States)

    Martin, Taylor; Brasiel, Sarah J.; Turner, Herb; Wise, John C.

    2012-01-01

    This study examines the effects of Connected Mathematics Project 2 (CMP2) on grade 6 student mathematics achievement and engagement using a cluster randomized controlled trial (RCT) design. It responds to a need to improve mathematics learning in the Mid-Atlantic Region (Delaware, Maryland, New Jersey, Pennsylvania, and Washington, DC). Findings…

  18. Achieving professionalism

    Directory of Open Access Journals (Sweden)

    R.A.E. Thompson

    1983-09-01

    Full Text Available In approaching the subject of professionalism the author has chosen to focus on the practical aspects rather than the philosophical issues. In so doing an attempt is made to identify criteria which demonstrate the achievement of the essence of professionalism.

  19. Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations.

    Science.gov (United States)

    Johnston, Michael J W; Semple, Sean C; Klimuk, Sandra K; Edwards, Katarina; Eisenhardt, Merete L; Leng, Esther C; Karlsson, Göran; Yanko, Daniel; Cullis, Pieter R

    2006-01-01

    The anti-tumor efficacy of liposomal formulations of cell cycle dependent anticancer drugs is critically dependent on the rates at which the drugs are released from the liposomes. Previous work on liposomal formulations of vincristine have shown increasing efficacy for formulations with progressively slower release rates. Recent work has also shown that liposomal formulations of vincristine with higher drug-to-lipid (D/L) ratios exhibit reduced release rates. In this work, the effects of very high D/L ratios on vincristine release rates are investigated, and the antitumor efficacy of these formulations characterized in human xenograft tumor models. It is shown that the half-times (T(1/2)) for vincristine release from egg sphingomyelin/cholesterol liposomes in vivo can be adjusted from T(1/2) = 6.1 h for a formulation with a D/L of 0.025 (wt/wt) to T(1/2) = 117 h (extrapolated) for a formulation with a D/L ratio of 0.6 (wt/wt). The increase in drug retention at the higher D/L ratios appears to be related to the presence of drug precipitates in the liposomes. Variations in the D/L ratio did not affect the circulation lifetimes of the liposomal vincristine formulations. The relationship between drug release rates and anti-tumor efficacy was evaluated using a MX-1 human mammary tumor model. It was found that the antitumor activity of the liposomal vincristine formulations increased as D/L ratio increased from 0.025 to 0.1 (wt/wt) (T(1/2) = 6.1-15.6 h respectively) but decreased at higher D/L ratios (D/L = 0.6, wt/wt) (T(1/2) = 117 h). Free vincristine exhibited the lowest activity of all formulations examined. These results demonstrate that varying the D/L ratio provides a powerful method for regulating drug release and allows the generation of liposomal formulations of vincristine with therapeutically optimized drug release rates.

  20. Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib

    Science.gov (United States)

    Shah, Neil P.; Kim, Dong-Wook; Kantarjian, Hagop; Rousselot, Philippe; Llacer, Pedro Enrique Dorlhiac; Enrico, Alicia; Vela-Ojeda, Jorge; Silver, Richard T.; Khoury, Hanna Jean; Müller, Martin C.; Lambert, Alexandre; Matloub, Yousif; Hochhaus, Andreas

    2010-01-01

    Background Dasatinib 100 mg once daily achieves intermittent BCR-ABL kinase inhibition and is approved for chronic-phase chronic myeloid leukemia patients resistant or intolerant to imatinib. To better assess durability of response to and tolerability of dasatinib, data from a 2-year minimum follow-up for a dose-optimization study in chronic-phase chronic myeloid leukemia are reported here. Design and Methods In a phase 3 study, 670 chronic-phase chronic myeloid leukemia patients with resistance, intolerance, or suboptimal response to imatinib were randomized to dasatinib 100 mg once-daily, 50 mg twice-daily, 140 mg once-daily, or 70 mg twice-daily. Results Data from a 2-year minimum follow-up demonstrate that dasatinib 100 mg once daily achieves major cytogenetic response and complete cytogenetic response rates comparable to those in the other treatment arms, and reduces the frequency of key side effects. Comparable 2-year progression-free survival and overall survival rates were observed (80% and 91%, respectively, for 100 mg once daily, and 75%–76% and 88%–94%, respectively, in other arms). Complete cytogenetic responses were achieved rapidly, typically by 6 months. In patients treated with dasatinib 100 mg once daily for 6 months without complete cytogenetic response, the likelihood of achieving such a response by 2 years was 50% for patients who had achieved a partial cytogenetic response, and only 8% or less for patients with minor, minimal, or no cytogenetic response. Less than 3% of patients suffered disease transformation to accelerated or blast phase. Conclusions Intermittent kinase inhibition can achieve rapid and durable responses, indistinguishable from those achieved with more continuous inhibition. PMID:20139391

  1. Urinary albumin excretion rate: a risk factor for retinal hard exudates in macular region in type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    Wang Shaocheng; Lin Siyong; Cao Xi; Zheng Yuezhong; Wang Jinyang; Lu Na; Yang Jinkui

    2014-01-01

    Background The various risk factors for retinal hard exudates are still poorly understood in type 2 diabetic patients.The aim of this study was to determine the association between urinary albumin excretion rate (UAER) and hard exudates in macular region in north Chinese patients.Methods A total of 272 patients (272 eyes) were enrolled for this study,including 154 subjects from group 1 (mild hard exudates),91 subjects from group 2 (moderate hard exudates) and 27 subjects from group 3 (severe hard exudates) confirmed using colour fundus photography,optical coherence tomography (OCT) as well as slit-lamp biomicroscopy with 78 diopter (D) lens.Each participant underwent a comprehensive assessment that included biochemical,clinical characteristics test and detailed ophthalmic evaluation.One-way analysis of variance (ANOVA) test and chi-square test were performed to analyze the fasting blood glucose (FBG),glycated hemoglobin (HbA1c),total cholesterol (TC),low density lipoprotein (LDL),high density lipoprotein (HDL),triglycerides (TG),full blood counts,urinary albumin excretion rate (UAER),blood creatinine (CREA),duration of diabetes,body mass index (BMI),systolic blood pressures (SBP) and diastolic blood pressures (DBP) between groups.Ordinal logistic regression analysis was further performed in order to eliminating the possible confounding factors.Results Three groups were matched in terms of age and gender.Risk factors which showed significant difference between groups include FBG (P <0.001),HbA1c (P <0.001),LDL (P <0.001),UAER (P <0.001),duration of diabetes (P=0.001),TC (P=0.005),SBP (P=0.026),CREA (P=0.004) and haemoglobin (Hb) (P=0.012).There was no significant difference between groups for the TG,HDL,DBP,platelet,total white blood cells and BMI.Using ordinal Logistic regression analyses,of all the variables,HbA1c,LDL and UAER which were independent risk factor for hard exudates showed a significantly odds ratio of 1.25,3.07,and 1.39,respectively

  2. Variability in caesarean section rates for very preterm births at 28-31 weeks of gestation in 10 European regions: results of the MOSAIC project

    DEFF Research Database (Denmark)

    Zeitlin, Jennifer; Di Lallo, Dominico; Blondel, Béatrice

    2010-01-01

    Given the continuing debate about the benefits of caesarean section for very preterm infants, we sought to describe caesarean section rates for infants between 28 and 31 weeks of gestation in European regions and their association with regional mortality and short-term morbidity....

  3. Variability in caesarean section rates for very preterm births at 28-31 weeks of gestation in 10 European regions: results of the MOSAIC project.

    NARCIS (Netherlands)

    Zeitlin, J.; Lallo, D. Di; Blondel, B.; Weber, T.; Schmidt, S.; Kunzel, W.; Kollee, L.A.A.; Papiernik, E.

    2010-01-01

    OBJECTIVE: Given the continuing debate about the benefits of caesarean section for very preterm infants, we sought to describe caesarean section rates for infants between 28 and 31 weeks of gestation in European regions and their association with regional mortality and short-term morbidity. STUDY DE

  4. A socio-hydrological comparative assessment explaining regional variances in suicide rate amongst farmers in Maharashtra, India

    Science.gov (United States)

    den Besten, Nadja I.; Pande, Saket; Savenije, Hubert H. G.

    2016-05-01

    Maharashtra is one of the states in India that has witnessed one of the highest rates of farmer suicides as proportion of total number of suicides. Most of the farmer suicides in Maharashtra are from semi-arid divisions such as Marathwada where cotton has been historically grown. Other dominant crops produced include cereals, pulses, oilseeds and sugarcane. Cotton (fibers), oilseeds and sugarcane providing highest value addition per unit cultivated area and cereals and pulses the least. Hence it is not surprising that smallholders take risks growing high value crops without "visualising" the risks it entails such as those corresponding to price and weather shocks.We deploy recently developed smallholder socio-hydrology modelling framework to understand the underlying dynamics of the crisis. It couples the dynamics of six main variables that are most relevant at the scale of a smallholder: water storage capacity (root zone storage and other ways of water storage), capital, livestock, soil fertility and fodder biomass. The hydroclimatic variability is accounted for at sub-annual scale and influences the socio-hydrology at annual scale. The model incorporates rule-based adaptation mechanisms (e.g., adjusting expenditures on food and fertilizers, selling livestocks) of smallholders when they face adverse conditions, such as high variability in rainfall or in agricultural prices. The model is applied to two adjoining divisions of Maharashtra: Marathwada and Desh. The former is the division with relatively higher farmer suicide rates than the latter. Diverse spatial data sets of precipitation, potential evaporation, soil, agricultural census based farm inputs, cropping pattern and prices are used to understand the dynamics of small farmers in these divisions, and to attribute farmer distress rates to soil types, hydroclimatic variability and crops grown.Comparative socio-hydrologic assessment across the two regions confirms existing narratives: low (soil) water storage

  5. Weak-Line Quasars at High Redshift: Extremely High Accretion Rates or Anemic Broad-Line Regions?

    CERN Document Server

    Shemmer, Ohad; Anderson, Scott F; Brandt, W N; Diamond-Stanic, Aleksandar M; Fan, Xiaohui; Lira, Paulina; Netzer, Hagai; Plotkin, Richard M; Richards, Gordon T; Schneider, Donald P; Strauss, Michael A

    2010-01-01

    We present Gemini-North K-band spectra of two representative members of the class of high-redshift quasars with exceptionally weak rest-frame ultraviolet emission lines (WLQs), SDSS J114153.34+021924.3 at z=3.55 and SDSS J123743.08+630144.9 at z=3.49. In both sources we detect an unusually weak broad H_beta line and we place tight upper limits on the strengths of their [O III] lines. Virial, H_beta-based black-hole mass determinations indicate normalized accretion rates of L/L_Edd=0.4 for these sources, which is well within the range observed for typical quasars with similar luminosities and redshifts. We also present high-quality XMM-Newton imaging spectroscopy of SDSS J114153.34+021924.3 and find a hard-X-ray photon index of Gamma=1.91^{+0.24}_{-0.22} which supports the virial L/L_Edd determination in this source. Our results suggest that the weakness of the broad-emission lines in WLQs is not a consequence of an extreme continuum-emission source but instead due to abnormal broad-emission line region proper...

  6. Anti-optic-null medium: Achieving the optic-null medium effect by enclosing an air region with relatively low-anisotropy media

    Science.gov (United States)

    Sun, Fei; Liu, Yichao; He, Sailing

    2016-07-01

    A so-called anti-optic-null medium (anti-ONM), which can be utilized to cancel the optic-null medium (ONM) and create many novel optical illusions, is introduced and designed by transformation optics (TO). Optical separation illusions can be achieved with an anti-ONM. With the help of the anti-ONM, we can achieve the same optical illusions where ONM is required via a shelled structure filled with low anisotropic medium, which is easier to realize for some novel optical devices designed by TO and optical surface transformation. The special function of the anti-ONM will lead to a new way to design optical devices or simplify the material requirements. Overlapping illusions, and wave-front reshapers are designed to demonstrate the function of the proposed method.

  7. Predicted detection rates of regional-scale meteorite impacts on Mars with the InSight short-period seismometer

    Science.gov (United States)

    Teanby, N. A.

    2015-08-01

    In 2016 NASA will launch the InSight discovery-class mission, which aims to study the detailed internal structure of Mars for the first time. Short- and long-period seismometers form a major component of InSight's payload and have the potential to detect seismic waves generated by meteorite impacts. Large globally detectable impact events producing craters with diameters of ∼ 100 m have been investigated previously and are likely to be rare (Teanby, N.A., Wookey, J. [2011]. Phys. Earth Planet. Int. 186, 70-80), but smaller impacts producing craters in the 0.5-20 m range are more numerous and potentially occur sufficiently often to be detectable on regional scales (≲1000 km). At these distances, seismic waves will have significant high frequency content and will be suited to detection with InSight's short-period seismometer SEIS-SP. In this paper I estimate the current martian crater production function from observations of new craters (Malin, M.C. et al. [2006]. Science 314, 1573-1577; Daubar, I.J. et al. [2013]. Icarus 225, 506-516), model results (Williams, J.P., Pathare, A.V., Aharonson, O. [2014]. Icarus 235, 23-36), and standard isochrons (Hartmann, W.K. [2005]. Icarus 174, 294-320). These impact rates are combined with an empirical relation between impact energy, source-receiver distance, and peak seismogram amplitude, derived from a compilation of seismic recordings of terrestrial and lunar impacts, chemical explosions, and nuclear tests. The resulting peak seismogram amplitude scaling law contains significant uncertainty, but can be used to predict impact detection rates. I estimate that for a short-period instrument, with a noise spectral density of 10-8 ms-2 Hz-1/2 in the 1-16 Hz frequency band, approximately 0.1-30 regional impacts per year should be detectable with a nominal value of 1-3 impacts per year. Therefore, small regional impacts are likely to be a viable source of seismic energy for probing Mars' crustal and upper mantle structure. This is

  8. General and specific factors in the explanation of regional variation of hospital admission rates: policy consequences for Belgium and the Netherlands.

    NARCIS (Netherlands)

    Groenewegen, P.P.; Zee, J. van der

    1987-01-01

    The analysis of regional variations in hospital admission rates for Belgium and the Netherlands shows that the available number of hospital beds together with the health status of the population (roughly indicated by age-adjusted mortality rates) are common factors to influence these admissions in

  9. General and specific factors in the explanation of regional variation of hospital admission rates: policy consequences for Belgium and the Netherlands

    NARCIS (Netherlands)

    Zee, J. van der; Groenewegen, P.P.

    The analysis of regional variations in hospital admission rates for Belgium and the Netherlands shows that the available number of hospital beds together with the health status of the population (roughly indicated by age-adjusted mortality rates) are common factors to influence these admissions in

  10. How can we further improve the LDL-cholesterol target level achievement rate based on the Hungarian MULTI GAP 2011 study results and considering the new European dyslipidemia guidelines?

    Science.gov (United States)

    Mark, Laszlo; Paragh, György; Karadi, Istvan; Reiber, Istvan; Pados, Gyula; Kiss, Zoltan

    2012-09-08

    Despite the continuous improvement of the quality of lipid lowering therapy the achievement of target values is still not satisfactory, mainly in the very high cardiovascular risk category patients, where the goal of low density lipoprotein cholesterol (LDL-C) is 1.80 mmol/l. The trends in lipid lowering treatment of 17420 patients from different studies conducted between 2004 and 2010 were compared to that of 1626 patients of MULTI GAP (MULTI Goal Attainment Problem) 2011 treated by general practitioners (GPs) and specialists. In MULTI GAP 2011 the mean LDL-C level ± SD) of patients treated by GPs was found to be 2.87 ±1.01 mmol/l, the target value of 2.50 was achieved by 40% of them, in the specialists' patients the mean LDL-C level proved to be 2.77 ±1.10 mmol/l and the achievement rate was 45%. In the 2.50 mmol/l achievement rate of GPs' patients a satisfactory improvement was observed in the studied years, but the 1.80 mmol/l LDL-C goal in 2011 was attained only in 11% of very high risk cases. There was a linear correlation between the patient compliance estimated by the physicians and the LDL-C achievement rate. As the number of very high risk category patients has been increased according to the new European dyslipidemia guidelines, growing attention needs to be placed on attainment of the 1.80 mmol/l LDL-C level. Based on the results of the MULTI GAP studies, improving patients' adherence and the continuous training of physicians are necessary.

  11. Development of the Instructional Model of Reading English Strategies for Enhancing Sophomore Students' Learning Achievements in the Institute of Physical Education in the Northeastern Region of Thailand

    Science.gov (United States)

    Whankhom, Prawit; Phusawisot, Pilanut; Sayankena, Patcharanon

    2016-01-01

    The aim of this research is to develop and verify the effectiveness of an instructional model of reading English strategies for students of Mahasarakham Institute of Physical Education in the Northeastern region through survey. Classroom action research techniques with the two groups of sample sizes of 34 sophomore physical students as a control…

  12. Rates of basin-wide rockwall retreat in the K2 region of the Central Karakoram defined by terrestrial cosmogenic nuclide 10Be

    Science.gov (United States)

    Seong, Yeong Bae; Owen, Lewis A.; Caffee, Marc W.; Kamp, Ulrich; Bishop, Michael P.; Bush, Andrew; Copland, Luke; Shroder, John F.

    2009-06-01

    Basin-wide rockwall retreat rates are estimated using cosmogenic 10Be concentrations in supraglacial debris from the Baltoro Glacier basin in K2 region of the Central Karakoram, Pakistan. Total cosmogenic 10Be concentrations of the supraglacial debris were measured using accelerator mass spectrometry to determine 10Be concentrations inherited from the rockwalls within the glaciated basin. Given that rockfall induced by periglacial weathering and snow and ice avalanches is the most important source of supraglacial debris production in the high mountain glaciated basin, the erosion rate of the bare bedrock can be considered to be the rate of rockwall retreat. The rate of the rockwall erosion, converted from the calculated inheritance of 10Be concentrations, using the maximum velocity of the active glacier, places an upper limit ranging from 0.65 mm/year to 2.48 mm/year. This rate of rockwall retreat is in the same order of magnitude reported in other high Himalayan mountains. The rate, however, is an order of magnitude higher than erosion rates inferred from sediment budget studies and half that of the fluvial incision rate and exhumation rate for the same region. The difference between rates of basin-wide rockwall retreat and fluvial incision rates over the Late Quaternary suggests that in this glaciated basin fluvial incision is likely enhanced by localized/differential tectonism and/or isostatic uplift.

  13. Data from Theodolite Measurements of Creep Rates on San Francisco Bay Region Faults, California: 1979-2007

    Science.gov (United States)

    McFarland, Forrest S.; Lienkaemper, James J.; Caskey, S. John; Grove, Karen

    2007-01-01

    Introduction Our purpose is to update with six additional years of data, our creep data archive on San Francisco Bay region active faults for use by the scientific research community. Earlier data (1979-2001) were reported in Galehouse (2002) and were analyzed and described in detail in a summary report (Galehouse and Lienkaemper, 2003). A complete analysis of our earlier results obtained on the Hayward fault was presented in Lienkaemper, Galehouse and Simpson (2001). Jon Galehouse of San Francisco State University (SFSU) and many student research assistants measured creep (aseismic slip) rates on these faults from 1979 until his retirement from the project in 2001. The creep measurement project, which was initiated by Galehouse, has continued through the Geosciences Department at SFSU from 2001-2006 under the direction of Co-P.I.'s Karen Grove and John Caskey (Grove and Caskey, 2005), and by Caskey since 2006. Forrest McFarland has managed most of the technical and logistical project operations as well as data processing and compilation since 2001. We plan to publish detailed analyses of these updated creep data in future publications. We maintain a project web site (http://funnel.sfsu.edu/creep/) that includes the following information: project description, project personnel, creep characteristics and measurement, map of creep measurement sites, creep measurement site information, and data plots for each measurement site. Our most current, annually updated results are therefore accessible to the scientific community and to the general public. Information about the project can currently be requested by the public by an email link (fltcreep@sfsu.edu) found on our project website.

  14. REGIONAL TRENDS IN THE WORKING-AGE POPULATION MORTALITY RATE IN THE REPUBLIC OF SAKHA (YAKUTIA) IN 1990-2012.

    Science.gov (United States)

    Ivanova, A A; Kakorina, E P; Timofeev, L F; Potapov, A F; Aprosimov, L A

    2015-01-01

    Regions of the Russian Federation differ in climatic-geographic, medical-demographic and social-economic situations. One of the regions with distinct peculiarities is the Republic of Sakha (Yakutia). Ranking first by the territory (3,103.2 thousand sq x km), Yakutia is on the 81th place by the population density among regions of the Russian Federation (0.3 people per 1 km2).Yakutia is one of the most isolated and inaccessible regions of the world: 90% of the territory lacks all-the-year-round transportation. Regions of the republic, as well, differ significantly in the climatic conditions and the levels of social-economic development, which influences the population health indicators, including mortality. This survey aimed to study the trends of mortality in the working-age population in different groups of regions. To do this, basing on the statistical data, we compared the levels, trends and structure of mortality in 1990-2012. It was established that the different groups of regions show a significant variation in the working-age population mortality, depending on the social-economic conditions. Since 2000, the Arctic group of regions has demonstrated higher mortality in working-age men and women, especially of cardiovascular and digestive system diseases, and external causes. Lying beyond the Arctic Circle, these regions have severe conditions and a relatively low level of social-economic development. As for the rural regions, despite the relatively favourabe situation, they also show a high level of mortality of external causes. The industrial regions are characterized by higher social-economic development, better transport infrastructure, a satisfactory material base of medical institutions. They also have sufficient resources of health institutions, including the staff and modern equipment for treatment and diagnostics, as well as, which is critical, the full range of medical specialists. Thus, these regions demonstrate lower population mortality; however

  15. The evolutionary rates of HCV estimated with subtype 1a and 1b sequences over the ORF length and in different genomic regions.

    Directory of Open Access Journals (Sweden)

    Manqiong Yuan

    Full Text Available BACKGROUND: Considerable progress has been made in the HCV evolutionary analysis, since the software BEAST was released. However, prior information, especially the prior evolutionary rate, which plays a critical role in BEAST analysis, is always difficult to ascertain due to various uncertainties. Providing a proper prior HCV evolutionary rate is thus of great importance. METHODS/RESULTS: 176 full-length sequences of HCV subtype 1a and 144 of 1b were assembled by taking into consideration the balance of the sampling dates and the even dispersion in phylogenetic trees. According to the HCV genomic organization and biological functions, each dataset was partitioned into nine genomic regions and two routinely amplified regions. A uniform prior rate was applied to the BEAST analysis for each region and also the entire ORF. All the obtained posterior rates for 1a are of a magnitude of 10(-3 substitutions/site/year and in a bell-shaped distribution. Significantly lower rates were estimated for 1b and some of the rate distribution curves resulted in a one-sided truncation, particularly under the exponential model. This indicates that some of the rates for subtype 1b are less accurate, so they were adjusted by including more sequences to improve the temporal structure. CONCLUSION: Among the various HCV subtypes and genomic regions, the evolutionary patterns are dissimilar. Therefore, an applied estimation of the HCV epidemic history requires the proper selection of the rate priors, which should match the actual dataset so that they can fit for the subtype, the genomic region and even the length. By referencing the findings here, future evolutionary analysis of the HCV subtype 1a and 1b datasets may become more accurate and hence prove useful for tracing their patterns.

  16. KUBAN REGION RAILROAD DURING THE SECOND FIVE-YEAR PLAN: CHALLENGES OF REARRANGING THE MAINTENANCE SCHEDULE AND LABOUR ACHIEVEMENTS BY THE WORKERS

    Directory of Open Access Journals (Sweden)

    Vladimir Eugenyevich Temlyakov

    2015-01-01

    Full Text Available The paper considered the issues the Kuban Region railroad transportation has faced during the Second Five-Year Plan. The author has brought to light the ways people had to cope with the challenges in rearranging the maintenance schedule at the Northern Caucasus Railroad Dept., and the staffing issue being pressing at that period. The survey has shown the part taken by the Communist Party and pubic administration bodies in implementing tasks the railroad transportation has faced. The paper examined resolutions taken in the 1930-ies by the Krasnodar city CPSU conferences and the Krasnodar city Party activists in relation to challenges the railroad transportation faced. The author made an inference that the new means and labour incentive approaches have taken the main part in increasing the rail traffic flow, and wide spreading of socialist emulation and the raising Stakhanovism on the railroad as well.

  17. Impact of aerosol vertical distribution on aerosol direct radiative effect and heating rate in the Mediterranean region

    Science.gov (United States)

    Pappas, Vasileios; Hatzianastassiou, Nikolaos; Matsoukas, Christos; Koras Carracca, Mario; Kinne, Stefan; Vardavas, Ilias

    2015-04-01

    It is now well-established that aerosols cause an overall cooling effect at the surface and a warming effect within the atmosphere. At the top of the atmosphere (TOA), both positive and negative forcing can be found, depending on a number of other factors, such as surface albedo and relative position of clouds and aerosols. Whilst aerosol surface cooling is important due to its relation with surface temperature and other bio-environmental reasons, atmospheric heating is of special interest as well having significant impacts on atmospheric dynamics, such as formation of clouds and subsequent precipitation. The actual position of aerosols and their altitude relative to clouds is of major importance as certain types of aerosol, such as black carbon (BC) above clouds can have a significant impact on planetary albedo. The vertical distribution of aerosols and clouds has recently drawn the attention of the aerosol community, because partially can account for the differences between simulated aerosol radiative forcing with various models, and therefore decrease the level of our uncertainty regarding aerosol forcing, which is one of our priorities set by IPCC. The vertical profiles of aerosol optical and physical properties have been studied by various research groups around the world, following different methodologies and using various indices in order to present the impact of aerosols on radiation on different altitudes above the surface. However, there is still variability between the published results as to the actual effect of aerosols on shortwave radiation and on heating rate within the atmosphere. This study uses vertical information on aerosols from the Max Planck Aerosol Climatology (MAC-v1) global dataset, which is a combination of model output with quality ground-based measurements, in order to provide useful insight into the vertical profile of atmospheric heating for the Mediterranean region. MAC-v1 and the science behind this aerosol dataset have already

  18. Identification and characterization of genomic regions on chromosomes 4 and 8 that control the rate of photosynthesis in rice leaves

    OpenAIRE

    2011-01-01

    DNA marker-assisted selection appears to be a promising strategy for improving rates of leaf photosynthesis in rice. The rate of leaf photosynthesis was significantly higher in a high-yielding indica variety, Habataki, than in the most popular Japanese variety, Koshihikari, at the full heading stage as a result of the higher level of leaf nitrogen at the same rate of application of nitrogen and the higher stomatal conductance even when the respective levels of leaf nitrogen were the same. The...

  19. Longitudinal Assessment of Global and Regional Rate of Grey Matter Atrophy in 1,172 Healthy Older Adults: Modulation by Sex and Age

    Science.gov (United States)

    Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Tzourio, Christophe; Mazoyer, Bernard

    2014-01-01

    To characterize the neuroanatomical changes in healthy older adults is important to differentiate pathological from normal brain structural aging. The present study investigated the annualized rate of GM atrophy in a large sample of older participants, focusing on the hippocampus, and searching for modulation by age and sex. In this 4-year longitudinal community cohort study, we used a VBM analysis to estimate the annualized rate of GM loss, at both the global and regional levels, in 1,172 healthy older adults (65–82 years) scanned at 1.5T. The global annualized rate of GM was −4.0 cm3/year (−0.83%/year). The highest rates of regional GM loss were found in the frontal and parietal cortices, middle occipital gyri, temporal cortex and hippocampus. The rate of GM atrophy was higher in women (−4.7 cm3/year, −0.91%/year) than men (−3.3 cm3/year, −0.65%/year). The global annualized rate of GM atrophy remained constant throughout the age range of the cohort, in both sexes. This pattern was replicated at the regional level, with the exception of the hippocampi, which showed a rate of GM atrophy that accelerated with age (2.8%/year per year of age) similarly for men and women. The present study reports a global and regional description of the annualized rate of grey matter loss and its evolution after the age of 65. Our results suggest greater anatomical vulnerability of women in late life and highlight a specific vulnerability of the hippocampus to the aging processes after 65 years of age. PMID:25469789

  20. Probability-based classifications for spatially characterizing the water temperatures and discharge rates of hot springs in the Tatun Volcanic Region, Taiwan.

    Science.gov (United States)

    Jang, Cheng-Shin

    2015-05-01

    Accurately classifying the spatial features of the water temperatures and discharge rates of hot springs is crucial for environmental resources use and management. This study spatially characterized classifications of the water temperatures and discharge rates of hot springs in the Tatun Volcanic Region of Northern Taiwan by using indicator kriging (IK). The water temperatures and discharge rates of the springs were first assigned to high, moderate, and low categories according to the two thresholds of the proposed spring classification criteria. IK was then used to model the occurrence probabilities of the water temperatures and discharge rates of the springs and probabilistically determine their categories. Finally, nine combinations were acquired from the probability-based classifications for the spatial features of the water temperatures and discharge rates of the springs. Moreover, various combinations of spring water features were examined according to seven subzones of spring use in the study region. The research results reveal that probability-based classifications using IK provide practicable insights related to propagating the uncertainty of classifications according to the spatial features of the water temperatures and discharge rates of the springs. The springs in the Beitou (BT), Xingyi Road (XYR), Zhongshanlou (ZSL), and Lengshuikeng (LSK) subzones are suitable for supplying tourism hotels with a sufficient quantity of spring water because they have high or moderate discharge rates. Furthermore, natural hot springs in riverbeds and valleys should be developed in the Dingbeitou (DBT), ZSL, Xiayoukeng (XYK), and Macao (MC) subzones because of low discharge rates and low or moderate water temperatures.

  1. Regional variation in suicide rates in Sri Lanka between 1955 and 2011: a spatial and temporal analysis.

    Science.gov (United States)

    Knipe, Duleeka W; Padmanathan, Prianka; Muthuwatta, Lal; Metcalfe, Chris; Gunnell, David

    2017-02-14

    Between 1955 and 2011 there were marked fluctuations in suicide rates in Sri Lanka; incidence increased six-fold between 1955 and the 1980s, and halved in the early 21st century. Changes in access to highly toxic pesticides are thought to have influenced this pattern. This study investigates variation in suicide rates across Sri Lanka's 25 districts between 1955 and 2011. We hypothesised that changes in the incidence of suicide would be most marked in rural areas due to the variation in availability of highly toxic pesticides in these locations during this time period. We mapped district-level suicide rates in 1955, 1972, 1980 and 2011. These periods preceded, included and postdated the rapid rise in Sri Lanka's suicide rates. We investigated the associations between district-level variations in suicide rates and census-derived measures of rurality (population density), unemployment, migration and ethnicity using Spearman's rank correlation and negative binomial models. The rise and fall in suicide rates was concentrated in more rural areas. In 1980, when suicide rates were at their highest, population density was inversely associated with area variation in suicide rates (r = -0.65; p suicides (r = -0.10; p = 0.697). There was no strong evidence that levels of migration or ethnicity were associated with area variations in suicide rates. The relative rates of suicide in the most rural compared to the most urban districts before (1955), during (1980) and after (2011) the rise in highly toxic pesticide availability were 1.1 (95% CI 0.5 to 2.4), 3.7 (2.0 to 6.9) and 2.1 (1.6 to 2.7) respectively. The findings provide some support for the hypothesis that changes in access to pesticides contributed to the marked fluctuations in Sri Lanka's suicide rate, but the impact of other factors cannot be ruled out.

  2. Geomagnetic storms link to the mortality rate in the Smolyan region for the period 1988--2009

    Science.gov (United States)

    Simeonova, Siyka G. 1; Georgieva, Radostina C. 2; Dimitrova, Boryana H. 2; Slavcheva, Radka G. 2; Kerimova, Bojena P. 2; Georgiev, Tsvetan B. 34

    We present correlations and trends of 10 parameters of annual mortality rate (1 to common mortality rate, 5 to cardiovascular reasons and 4 to "accidental" reasons (car accidents, suicides, infections)) with respect to 6 parameters of annual solar and geomagnetic activity (Wolf index, number of geomagnetic storms, duration of the storms, amplitude of the storms). During the period of observation, characterized by a 3-4-fold decrease of the mean geomagnetic activity (in terms of the number and the duration of the storms) and with a strong variations of the amplitude of the storms (about an almost constant mean values for the period), there is a 1.3-fold decrease in the urban population, a 1.5-fold increase of the common mortality rate, a 1.8-fold increase of the cardiovascular mortality rate and a 1.1-fold decrease of the "accidental" mortality rates. During the years 2003-2005 we observe about 2-fold temporary increase in the storm amplitudes. During the years 2007-2008, characterized by extremely low geomagnetic activity, we observe a surprising temporary increase of the common and the cardiovascular mortality rates 1.1 and 1.3-fold, respectively (Figures 1-4). We point out 3 main results. (1) The available data shows notable increase in the mortality rates while there is generally a decrease of the solar or geomagnetic activity during the studied period (Figures 5-9). We explain this anti-correlation with the domination of the increasing mortality rates as an effect of the advance in the mean age of the population (due to immigration of young people and decrease of new-borns), hiding an eventual display of the solar and geomagnetic influence on the mortality rates. Using this data we can not reveal influence of the long-time (10-20 years) change of the average solar and geomagnetic activity on the mortality rate. (2) Excluding the unusual years 2007 and 2008, we establish that with respect to the years with low geomagnetic activity (1993, 1995, 1996, 1999), in

  3. Achieve a Better Understanding of Cloud and Precipitation Processes for the Promotion of Water Security in Arid and Semi-Arid Regions

    Science.gov (United States)

    Farrah, S.; Al Yazidi, O.

    2016-12-01

    has been recently replaced by a new drive to solve the technical obstacles impeding its potential. There is now a real prospect that this science will come of age and play its rightful part in boosting sustainable water supplies for people at risk in arid and semi-arid regions of the world.

  4. Determinants of Calcium Infusion Rate During Continuous Veno-venous Hemofiltration with Regional Citrate Anticoagulation in Critically Ⅲ Patients with Acute Kidney Injury

    Institute of Scientific and Technical Information of China (English)

    De-Lin Liu; Li-Feng Huang; Wen-Liang Ma; Qi Ding; Yue Han; Yue Zheng; Wen-Xiong Li

    2016-01-01

    Background:It is unclear that how to decide the calcium infusion rate during continuous veno-venous hemofiltration (CVVH) with regional citrate anticoagulation (RCA).This study aimed to assess the determinants of calcium infusion rate during CVVH with RCA in critically ill patients with acute kidney injury (AKI).Methods:A total of 18 patients with AKI requiring CVVH were prospectively analyzed.Postdilution CVVH was performed with a fixed blood flow rate of 150 ml/min and a replacement fluid flow rate of 2000 ml/h for each new circuit.The infusion of 4% trisodium citrate was started at a rate of 29.9 mmol/h prefilter and adjusted according to postfilter ionized calcium.The infusion of 10% calcium gluconate was initiated at a rate of 5.5 mmol/h and adjusted according to systemic ionized calcium.The infusion rate oftrisodium citrate and calcium gluconate as well as ultrafiltrate flow rate were recorded at 1,2,4,6,12,and 24 h after starting CVVH,respectively.The calcium loss rate by CVVH was also calculated.Results:Fifty-seven sessions of CVVH were performed in 18 AKI patients.The citrate infusion rate,calcium loss rate by CVVH,and calcium infusion rate were 31.30 (interquartile range:2.70),4.60 ± 0.48,and 5.50 ± 0.35 mmol/h,respectively.The calcium infusion rate was significantly higher than that of calcium loss rate by CVVH (P < 0.01).The correlation coefficient between the calcium and citrate infusion rates,and calcium infusion and calcium loss rates by CVVH was-0.031 (P > 0.05) and 0.932 (P < 0.01),respectively.In addition,calcium infusion rate (mmol/h) =1.77 + 0.8 × (calcium loss rate by CVVH,mmol/h).Conclusions:The calcium infusion rate correlates significantly with the calcium loss rate by CVVH but not with the citrate infusion rate in a fixed blood flow rate during CVVH with RCA.

  5. Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences.

    Science.gov (United States)

    Singer, I I; Kawka, D W; DeMartino, J A; Daugherty, B L; Elliston, K O; Alves, K; Bush, B L; Cameron, P M; Cuca, G C; Davies, P

    1993-04-01

    The murine anti-CD18 mAb 1B4 has been humanized using CDR grafting. Three VH (Gal, Jon, and New) and two VL (Rei and Len) human frameworks, whose selection was based exclusively on their sequence identity with m1B4, were used to construct five human gamma 4/kappa recombinant antibodies: Gal/Rei, Gal/Len, Jon/Rei, and New/Rei, and a "hemichimeric" antibody pairing the VH of m1B4 with grafted Rei. Each of these h1B4 constructs completely inhibited the binding of m1B4 to activated human leukocytes with avidities (IC50) ranging from 1.5 to 8.0 nM, compared to 0.5 nM for m1B4. Replacement of three VH residues in the best VH framework, Gal, with the corresponding m1B4 "packing" (nonsolvent exposed) residues gave an h1B4 (mutant Gal/Rei) with the same avidity as m1B4. Avidity correlated with overall percent identity between the human and murine VH frameworks and, in particular, with conservation of "packing" residues. Rei and Len VL frameworks proved to be interchangeable. Further characterization showed that the Gal/Rei prototype was equipotent to m1B4 in blocking adhesion of polymorphonuclear leukocytes and monocytes to human vascular endothelium in vitro, and polymorphonuclear leukocyte extravasation into C5a-injected rabbit or monkey skin sites. Dual-label immunofluorescence microscopy of bone marrow cells with Gal/Rei h1B4 and m1B4 demonstrated that the fine specificity of the combining sites had not been altered by humanization. Reduced immunogenicity was demonstrated in rhesus monkeys that tolerated weekly treatment with h1B4 for 6 wk, whereas m1B4 induced profound anaphylaxis at 3 wk. Anti-1B4 titers in h1B4-treated rhesus were 50 to 66% lower and developed 1 wk later than in m1B4-treated monkeys. Crucially, the anti-h1B4 antibodies were anti-idiotypic while the anti-m1B4 antibodies were directed against constant and framework regions. We conclude that sequence identity searches are sufficient to identify suitable human frameworks for CDR-grafting of m1B4

  6. Achieving scale-independent land-surface flux estimates - Application of the Multiscale Parameter Regionalization (MPR) to the Noah-MP land-surface model across the contiguous USA

    Science.gov (United States)

    Thober, S.; Mizukami, N.; Samaniego, L. E.; Attinger, S.; Clark, M. P.; Cuntz, M.

    2016-12-01

    classical averaging operators used in MPR. This allows us to identify appropriate scalings for parameters that have not been investigated in MPR so far (e.g., maximum carboxylation rate). Using MPR for Noah-MP provides a considerable improvement of the physical consistency that we expect to be achievable also in other land-surface schemes.

  7. Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region

    Directory of Open Access Journals (Sweden)

    van Pittius Nicolaas

    2009-09-01

    Full Text Available Abstract Background PPE38 (Rv2352c is a member of the large PPE gene family of Mycobacterium tuberculosis and related mycobacteria. The function of PPE proteins is unknown but evidence suggests that many are cell-surface associated and recognised by the host immune system. Previous studies targeting other PPE gene members suggest that some display high levels of polymorphism and it is thought that this might represent a means of providing antigenic variation. We have analysed the genetic variability of the PPE38 genomic region on a cohort of M. tuberculosis clinical isolates representing all of the major phylogenetic lineages, along with the ancestral M. tuberculosis complex (MTBC member M. canettii, and supplemented this with analysis of publicly available whole genome sequences representing additional M. tuberculosis clinical isolates, other MTBC members and non tuberculous mycobacteria (NTM. Where possible we have extended this analysis to include the adjacent plcABC and PPE39/40 genomic regions. Results We show that the ancestral MTBC PPE38 region comprises 2 homologous PPE genes (PPE38 and PPE71, separated by 2 esat-6 (esx-like genes and that this structure derives from an esx/esx/PPE duplication in the common ancestor of M. tuberculosis and M. marinum. We also demonstrate that this region of the genome is hypervariable due to frequent IS6110 integration, IS6110-associated recombination, and homologous recombination and gene conversion events between PPE38 and PPE71. These mutations result in combinations of gene deletion, gene truncation and gene disruption in the majority of clinical isolates. These mutations were generally found to be IS6110 strain lineage-specific, although examples of additional within-lineage and even within-cluster mutations were observed. Furthermore, we provide evidence that the published M. tuberculosis H37Rv whole genome sequence is inaccurate regarding this region. Conclusion Our results show that this antigen

  8. Rapid ice unloading in the Fleming Glacier region, southern Antarctic Peninsula, and its effect on bedrock uplift rates

    DEFF Research Database (Denmark)

    Zhao, Chen; King, Matt A.; Watson, Christopher S.

    2017-01-01

    the Fleming Glacier, after the application of elastic and plate tectonic corrections, point away from Marguerite Bay rather than the present glacier front. This suggests that horizontal motion in the region reflects the earlier retreat of the glacier system following the LGM, compatible with a relatively...

  9. Regional inequalities in self-rated health and disability in younger and older generations in Turkey: the contribution of wealth and education.

    Science.gov (United States)

    Ergin, Isil; Kunst, Anton E

    2015-09-29

    In Turkey, large regional inequalities were found in maternal and child health. Yet, evidence on regional inequalities in adult health in Turkey remains fragmentary. This study aims to assess regional and rural/urban inequalities in the prevalence of poor self-rated health and in disability among adult populations in Turkey, and to measure the contribution of education and wealth of individual residents. The central hypothesis was that geographical inequalities in adult health exist even when the effect of education and wealth were taken into account. We analyzed data of the 2002 World Health Survey for Turkey on 10791 adults aged 20 years and over. We measured respondents' rating of their own general health and the prevalence of five types of physical disability. Logistic regression was used to estimate how much these two health outcomes varied according to urban/rural place of residence, region, education level and household wealth. We stratified the analyses by gender and age (‹50 and ≥50 years). Both health outcomes were strongly associated with educational level (especially for older age group) and with household wealth (especially for younger age group). Both health outcomes also varied according to region and rural/urban place of residence. Higher prevalence rates were observed in the East region (compared to West) with odd ratios varying between 1.40-2.76. After controlling for education and wealth, urban/rural differences in health disappeared, while regional differences were observed only among older women. The prevalence of poor self-rated health was higher for older women in the Middle (OR = 1.69), Black Sea (OR = 1.53) and East (OR = 2.06) regions. In Turkey, substantial geographical inequalities in self-reported adult health do exist, but can mostly be explained by differences in socioeconomic characteristics of residents. The regional disadvantage of older women in the East, Middle and Black Sea may have resulted from life

  10. A Quality Improvement Approach to Reducing the Caesarean section Surgical Site Infection Rate in a Regional Hospital

    LENUS (Irish Health Repository)

    O’ Hanlon, M

    2016-09-01

    Surgical site infection (SSI) rates are used extensively by hospitals as a basis for quality improvement. A 30-day post-discharge SSI programme for Caesarean section operations has been implemented in Our Lady of Lourdes Hospital since 2011. It has been shown that skin antisepsis and antibiotic prophylaxis are key factors in the prevention of SSI. Using quality improvement methodology, an infection prevention bundle was introduced to address these two factors. Skin antisepsis was changed from povidone-iodine to chlorhexidine-alcohol. Compliance with choice of antibiotic prophylaxis increased from 89.6% in 2014 to 98.5% in 2015. Compliance with timing also improved. The SSI rate of 7.5% was the lowest recorded to date, with the majority of SSIs (64%) diagnosed after hospital discharge. The level of variation was also reduced. However, the continued presence of variation and possibility of lower infection rates from the literature imply that further improvements are required.

  11. Experimental Identification and Simulation of Time and/or Rate Dependent Reversible and Irreversible Deformation Regions for both a Titanium and Nickel Alloy

    Science.gov (United States)

    Arnold, Steven M.; Lerch, Bradley A.; Sellers, Cory

    2013-01-01

    In this paper time and/or rate dependent deformation regions are experimentally mapped out as a function of temperature. It is clearly demonstrated that the concept of a threshold stress (a stress that delineate reversible and irreversible behavior) is valid and necessary at elevated temperatures and corresponds to the classical yield stress at lower temperatures. Also the infinitely slow modulus, (Es) i.e. the elastic modulus of the material if it was loaded at an infinitely slow strain rate, and the "dynamic modulus", modulus, Ed, which represents the modulus of the material if it is loaded at an infinitely fast rate are used to delineate rate dependent from rate independent regions. As demonstrated at elevated temperatures there is a significant difference between the two modulus values, thus indicating both significant time-dependence and rate dependence. In the case of the nickel-based super alloy, ME3, this behavior is also shown to be grain size specific. Consequently, at higher temperatures viscoelastic behavior exist below k (i.e., the threshold stress) and at stresses above k the behavior is viscoplastic. Finally a multi-mechanism, stress partitioned viscoelastic model, capable of being consistently coupled to a viscoplastic model is characterized over the full temperature range investigated for Ti-6-4 and ME3.

  12. The association of socioeconomic status of family and living region with self-rated health and life satisfaction in children and adolescents: The CASPIAN-IV study.

    Science.gov (United States)

    Mirmoghtadaee, Parisa; Heshmat, Ramin; Djalalinia, Shirin; Motamed-Gorji, Nazgol; Motlagh, Mohammad Esmaeil; Ardalan, Gelayol; Safiri, Saeid; Ahadi, Zeinab; Shafiee, Gita; Asayesh, Hamid; Qorbani, Mostafa; Yaghini, Omid; Kelishadi, Roya

    2016-01-01

    Background: Socioeconomic status (SES) is a major determinant of health inequality in children and adolescents. The aim of this study was to evaluate the association of SES of family and living region with self-rated health (SRH) and life satisfaction (LS) among children and adolescents. Methods: This study was a part of the fourth survey of a national surveillance program, which was conducted in 30 provinces of Iran in 2011-2012. LS and SRH were assessed by a questionnaire based on the World Health Organization-Global School-based student Health Survey (WHO-GSHS). Family SES was estimated using principal component analysis (PCA) and based on family assets, parental education and occupation, and type of school. Region SES was calculated using PCA and some variables including literacy rate, family assets and employment rate. Results: Out of 14,880 invited students, 13,486 (participation rate: 90.6%) completed the survey; of whom, 49.2% were girls, and 75.6% were from urban areas with the mean ± SD age of 12.47±3.36 years. In the multivariate model, SES of family and living region was associated with LS and good SRH. In the full models, in addition to all potential confounders, family and living region SES were included simultaneously. However, only the association of family SES with LS, and good SRH remained statistically significant. Conclusion: The effect of families' SES on SRH and LS is more important than regional SES. The presented patterns of SRH and LS may be useful in developing better health policies and conducting complementary studies in this field.

  13. Early Detection of Regional and Global Left Ventricular Myocardial Function Using Strain and Strain-rate Imaging in Patients with Metabolic Syndrome

    Institute of Scientific and Technical Information of China (English)

    Qin Wang; Qi-Wei Sun; Dan Wu; Ming-Wu Yang; Rong-Juan Li; Bo Jiang; Jiao Yang

    2015-01-01

    Background:Strain and strain-rate imaging (SRI) have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies,and identifying early subclinical changes in various pathologies.The aim of this study was to evaluate the regional and global left ventricular (LV) myocardial function in metabolic syndrome (MS) with SRI so that we can provide more myocardial small lesions in patients with MS,which is robust and reliable basis for early detection of LV function.Methods:Thirty-nine adults with MS were enrolled in the study.There was a control group of 39 healthy adults.In addition to classic echocardiographic assessment of LV global functional changes,SRI was used to evaluate regional and global LV function.Including:Peak systolic strain (S),peak systolic strain-rate (SR-s),peak diastolic strain-rate (SR-e).Results:There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function.On the other hand,significant differences were observed between MS and the control group in most of the parameters of S,SR-s,SR-e in regional LV function.Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure,waist circumference,fasting plasma glucose,uric acid,suggesting that risk factories were relevant to regional systolic dysfunction.Conclusion:In MS with normal LV ejection fraction,there was regional myocardial dysfunction,risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium.Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.

  14. Early Detection of Regional and Global Left Ventricular Myocardial Function Using Strain and Strain-rate Imaging in Patients with Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Qin Wang

    2015-01-01

    Full Text Available Background: Strain and strain-rate imaging (SRI have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early subclinical changes in various pathologies. The aim of this study was to evaluate the regional and global left ventricular (LV myocardial function in metabolic syndrome (MS with SRI so that we can provide more myocardial small lesions in patients with MS, which is robust and reliable basis for early detection of LV function. Methods: Thirty-nine adults with MS were enrolled in the study. There was a control group of 39 healthy adults. In addition to classic echocardiographic assessment of LV global functional changes, SRI was used to evaluate regional and global LV function. Including: Peak systolic strain (S, peak systolic strain-rate (SR-s, peak diastolic strain-rate (SR-e. Results: There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function. On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function. Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction. Conclusion: In MS with normal LV ejection fraction, there was regional myocardial dysfunction, risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium. Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.

  15. Regional stressing rate appears to control duration and decay of off-fault aftershocks in the 2011 M=9.0 Tohoku-oki, Japan, earthquake

    Science.gov (United States)

    Toda, S.; Stein, R. S.

    2013-12-01

    The 11 March 2001 M=9.0 Tohoku-oki, Japan, earthquake brought the unprecedented broad increase in seismicity over inland Japan and far offshore. The seismicity rate increase was observed at distances of up to 425 km from the locus of high seismic slip on the megathrust, which roughly corresponds to the areas over 0.1 bar Coulomb stress increase (e.g., Toda et al., 2011). Such stress perturbation in the entire eastern Honshu island gives us a great opportunity to test one of the hypotheses in rate and state friction of Dieterich (1994): aftershock duration (ta) is inversely proportional to fault stressing rate. The Tohoku-oki mainshock indeed started a stopwatch simultaneously for all the off-fault and on-fault aftershocks in various tectonic situations. We have carefully examined the aftershock decays fitting the Omori-Utsu formula in several activated regions, including on the 2011 source fault, several inland areas of Tohoku (Akita, Iwaki, northern Sendai, and Fukushima), Tokyo metropolitan area, Choshi (east of Tokyo), Izu Peninsula, and areas along the most active Itoigawa-Shizuoka Tectonic Line (ISTL) central Honshu. Comparing the regional aftershock decays with the background rates of seismicity estimated from the JMA catalog from 2000 to 2010, we measured ta. One of the extreme short duration was measured at the Izu Peninsula where the heightened seismicity was rapidly toned down to the normal in one month. Overall seismicity in the Tohoku mainshock zone has been mostly closing to normal in 2 - 3 years. Both regions are characterized by high loading rate due to plate collision and subduction. Seismicity beneath Tokyo, also characterized by complex plate interfaces and brought average 1 bar closer to failure, has not followed the simple Omori decay but being settled a new higher rate after a rapid decay. In contrast to these highly deformed regions, current seismicity in slowly loading Tohoku inland regions are still much higher than background rate, which

  16. Approaching Long Genomic Regions and Large Recombination Rates with msParSm as an Alternative to MaCS

    Science.gov (United States)

    Montemuiño, Carlos; Espinosa, Antonio; Moure, Juan C.; Vera, Gonzalo; Hernández, Porfidio; Ramos-Onsins, Sebastián

    2016-01-01

    The msParSm application is an evolution of msPar, the parallel version of the coalescent simulation program ms, which removes the limitation for simulating long stretches of DNA sequences with large recombination rates, without compromising the accuracy of the standard coalescence. This work introduces msParSm, describes its significant performance improvements over msPar and its shared memory parallelization details, and shows how it can get better, if not similar, execution times than MaCS. Two case studies with different mutation rates were analyzed, one approximating the human average and the other approximating the Drosophila melanogaster average. Source code is available at https://github.com/cmontemuino/msparsm. PMID:27721650

  17. Postoperative radiotherapy appeared to improve the disease free survival rate of patients with extrahepatic bile duct cancer at high risk of loco-regional recurrence

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Young; Kim, Jin Hee; Kim, Yong Hoon [Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu (Korea, Republic of); Byun, Sang Jun [Dept. of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2016-12-15

    To investigate the outcomes of postoperative radiotherapy (RT), in patients with extrahepatic bile duct (EHBD) cancer by comparing the survival rate between patients undergoing surgery alone or surgery plus postoperative RT, and to identify the prognostic factors affecting survival. Between 2000 and 2013, 52 patients with EHBD cancer underwent surgical resection. Of these, 33 patients did not receive postoperative RT (group I), and 19 patients did (group II). R1 resection was significantly more frequent in group II. The median radiation dose was 5,040 cGy. The 3-year overall survival (OS) rate for group I and group II was 38% and 56%, respectively (p = 0.274). The 3-year disease free survival (DFS) rate for group I and group II was 20% and 31%, respectively (p = 0.049), and the 3-year loco-regional recurrence free survival (LRFS) rates were 19% and 58%, respectively (p = 0.002). Multivariate analyses showed that postoperative RT and lymphovascular invasion were independent prognostic factors for DFS and LRFS. Overall, 42 patients (80%) experienced treatment failure. Distant metastasis was the predominant pattern of failure in group II. Postoperative RT after surgical resection appeared to improve the loco-regional control and DFS rate. More effort is needed to reduce distant metastasis, the major pattern of failure, in patients who receive postoperative RT.

  18. Recent peat accumulation rates in minerotrophic peatlands of the Bay James region, Eastern Canada, inferred by 210Pb and 137Cs radiometric techniques.

    Science.gov (United States)

    Ali, Adam A; Ghaleb, Bassam; Garneau, Michelle; Asnong, Hans; Loisel, Julie

    2008-10-01

    (210)Pb and (137)Cs dating techniques are used to characterise recent peat accumulation rates of two minerotrophic peatlands located in the La Grande Rivière hydrological watershed, in the James Bay region (Canada). Several cores were collected during the summer 2005 in different parts of the two selected peatlands. These minerotrophic patterned peatlands are presently affected by erosion processes, expressed by progressive mechanical destruction of their pools borders. This erosion process is related to a water table rise induced by a regional increase of humidity since the last century. The main objective of the present paper is to (1) evaluate if (210)Pb and (137)Cs dating techniques can be applied to build accurate chronologies in these environments and (2) detect changes in the peat accumulation rates in regard to this amplification of humidity. In both sites, unsupported (210)Pb shows an exponential decreasing according to the depth. Chronologies inferred from (210)Pb allow to reconstruct peat accumulation rates since ca. 1855 AD. The (137)Cs data displayed evident mobility and diffusion, preventing the establishment of any sustained chronology based on these measurements. In the two sites, peat accumulation rates inferred from (210)Pb chronologies fluctuate between 0.005 and 0.038 g cm(-2) yr(-1). As a result, the rise of the water table during the last decade has not yet affected peat accumulation rates.

  19. Red states, blue states, and divorce: understanding the impact of conservative Protestantism on regional variation in divorce rates.

    Science.gov (United States)

    Glass, Jennifer; Levchak, Philip

    2014-01-01

    Why do states with larger proportions of religious conservatives have higher divorce rates than states with lower proportions of religious conservatives? This project examines whether earlier transitions to marriage and parenthood among conservative Protestants (known risk factors for divorce) contribute to this paradox while attending to other plausible explanations. County-level demographic information from all 50 states is combined from a variety of public data sources and merged with individual records from the National Surveys of Family Growth to estimate both aggregated county and multilevel individual models of divorce. Results show that individual religious conservatism is positively related to individual divorce risk, solely through the earlier transitions to adulthood and lower incomes of conservative Protestants. However, the proportion of conservative Protestants in a county is also independently and positively associated with both the divorce rate in that county and an individual's likelihood of divorcing. The earlier family formation and lower levels of educational attainment and income in counties with a higher proportion of conservative Protestants can explain a substantial portion of this association. Little support is found for alternative explanations of the association between religious conservatism and divorce rates, including the relative popularity of marriage versus cohabitation across counties.

  20. The impact of landscape transformation on the reinfestation rates of Rhodnius prolixus in the Orinoco Region, Colombia.

    Science.gov (United States)

    Cordovez, Juan M; Guhl, Felipe

    2015-11-01

    Trypanosoma cruzi, the agent responsible for Chagas disease, is widely distributed in the Americas in association to insect vectors and animal reservoirs. Triatomines are common vectors of Chagas disease and they vary in their distribution and affinity to human or sylvatic environments. Thus, control programs that include house spraying have been successful in regions were insects have a tendency to domiciliation. In the Orinoco region of Colombia, Rhodnius prolixus is the main vector presenting a stable sylvatic cycle, but is also found colonizing human dwellings. In 1997, health authorities developed a control program in the Department of Casanare spreading with insecticide houses in 667 localities. Infestation Indexes (I.I.) were calculated at the locality level before and after spraying. Times for re-infestation assessment varied between 1 and 67 months. Localities were classified into 3 groups according to their I.I. after spraying. Group 1 dropped their I.I. down to zero, Group 2 had a drop but remained positive and Group 3 increased its I.I. after spraying. We classified each group in terms of their land use characteristics before and after spraying based on satellite images obtained for the years 1997 (beginning of the study) and 2002 (end of program). We found that spraying significantly reduce the I.I. on average. However, we found that time after spraying does not produce significant differences in the I.I. Interestingly, land use changes and variations on I.I. after spraying for all groups were significantly dependent.

  1. A new interpretation of deformation rates in the Snake River Plain and adjacent basin and range regions based on GPS measurements

    Science.gov (United States)

    Payne, S. J.; McCaffrey, R.; King, R. W.; Kattenhorn, S. A.

    2012-04-01

    Within the Northern Basin and Range Province, USA, we estimate horizontal velocities for 405 sites using Global Positioning System (GPS) phase data collected from 1994 to 2010. The velocities, together with geologic, volcanic, and earthquake data, reveal a slowly deforming region within the Snake River Plain in Idaho and Owyhee-Oregon Plateau in Oregon separated from the actively extending adjacent Basin and Range regions by shear. Our results show a NE-oriented extensional strain rate of 5.6 ± 0.7 × 10-9 yr-1 in the Centennial Tectonic Belt and an ˜E-oriented extensional strain rate of 3.5 ± 0.2 × 10-9 yr-1 in the Great Basin. These extensional rates contrast with the very low strain rate within the 125 km × 650 km region of the Snake River Plain and Owyhee-Oregon Plateau, which is indistinguishable from zero (-0.1 ± 0.4 × 10-9 yr-1). Inversions of the velocities with dyke-opening models indicate that rapid extension by dyke intrusion in volcanic rift zones, as previously hypothesized, is not currently occurring in the Snake River Plain. This slow internal deformation, in contrast to the rapidly extending adjacent Basin and Range regions, indicates shear along the boundaries of the Snake River Plain. We estimate right-lateral shear with slip rates of 0.3-1.4 mm yr-1 along the northwestern boundary adjacent to the Centennial Tectonic Belt and left-lateral oblique extension with slip rates of 0.5-1.5 mm yr-1 along the southeastern boundary adjacent to the Intermountain Seismic Belt. The fastest lateral shearing evident in the GPS occurs near the Yellowstone Plateau where strike-slip focal mechanisms and faults with observed strike-slip components of motion are documented. The regional velocity gradients are best fit by nearby poles of rotation for the Centennial Tectonic Belt, Snake River Plain, Owyhee-Oregon Plateau, and eastern Oregon, indicating that clockwise rotation is not locally driven by Yellowstone hotspot volcanism, but instead by extension to the

  2. Regional differences in rates of HIV-1 viral load monitoring in Canada: Insights and implications for antiretroviral care in high income countries

    Directory of Open Access Journals (Sweden)

    Cooper Curtis

    2010-02-01

    Full Text Available Abstract Background Viral load (VL monitoring is an essential component of the care of HIV positive individuals. Rates of VL monitoring have been shown to vary by HIV risk factor and clinical characteristics. The objective of this study was to determine whether there are differences among regions in Canada in the rates of VL testing of HIV-positive individuals on combination antiretroviral therapy (cART, where the testing is available without financial barriers under the coverage of provincial health insurance programs. Methods The Canadian Observational Cohort (CANOC is a collaboration of nine Canadian cohorts of HIV-positive individuals who initiated cART after January 1, 2000. The study included participants with at least one year of follow-up. Generalized Estimating Equation (GEE regression models were used to determine the effect of geographic region on (1 the occurrence of an interval of 9 months or more between two consecutive recorded VL tests and (2 the number of days between VL tests, after adjusting for demographic and clinical covariates. Overall and regional annual rates of VL testing were also reported. Results 3,648 individuals were included in the analysis with a median follow-up of 42.9 months and a median of 15 VL tests. In multivariable GEE logistic regression models, gaps in VL testing >9 months were more likely in Quebec (Odds Ratio (OR = 1.72, p Conclusions Significant variation in rates of VL testing and the probability of a significant gap in testing were related to geographic region, HIV risk factor, age, year of cART initiation, type of cART regimen, being in the first year of cART, AIDS-defining illness and whether or not the previous VL was below the limit of detection.

  3. Data from theodolite measurements of creep rates on San Francisco Bay region faults, California, 1979-2012

    Science.gov (United States)

    McFarland, Forrest S.; Lienkaemper, James J.; Caskey, S. John

    2009-01-01

    Our purpose is to annually update our creep-data archive on San Francisco Bay region active faults for use by the scientific research community. Earlier data (1979-2001) were reported in Galehouse (2002) and were analyzed and described in detail in a summary report (Galehouse and Lienkaemper, 2003). A complete analysis of our earlier results obtained on the Hayward Fault was presented in Lienkaemper, Galehouse and Simpson (2001) and updated in Lienkaemper and others (2012). Lienkaemper and others (2014a) provide a new overview and analysis of fault creep along all sections of the northern San Andreas Fault system, from which they estimate by how much fault creep reduces the seismic hazard for each fault section.

  4. Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Niklas Mattsson

    Full Text Available BACKGROUND: Cerebrospinal fluid (CSF α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer's disease (AD. No study has explored effects of CSF α-synuclein on brain atrophy. Here we tested if baseline CSF α-synuclein affects brain atrophy rates and if these effects vary across brain regions, and across the cognitive spectrum from healthy elders (NL, to patients with mild cognitive impairment (MCI and AD. METHODS: Baseline CSF α-synuclein measurements and longitudinal structural brain magnetic resonance imaging was performed in 74 NL, 118 MCI patients and 55 AD patients. Effects of baseline CSF α-synuclein on regional atrophy rates were tested in 1 four pre-hoc defined regions possibly associated with Lewy body and/or AD pathology (amygdala, caudate, hippocampus, brainstem, and 2 all available regions of interest. Differences across diagnoses were tested by assessing the interaction of CSF α-synuclein and diagnosis (testing NL versus MCI, and NL versus AD. RESULTS: The effects of CSF α-synuclein on longitudinal atrophy rates were not significant after correction for multiple comparisons. There were tendencies for effects in AD in caudate (higher atrophy rates in subjects with higher CSF α-synuclein, P=0.046 and brainstem (higher atrophy rates in subjects with lower CSF α-synuclein, P=0.063. CSF α-synuclein had significantly different effects on atrophy rates in NL and AD in brainstem (P=0.037 and caudate (P=0.006. DISCUSSION: With the possible exception of caudate and brainstem, the overall weak effects of CSF α-synuclein on atrophy rates in NL, MCI and AD argues against CSF α-synuclein as a biomarker related to longitudinal brain atrophy in these diagnostic groups. Any effects of CSF α-synuclein may be attenuated by possible simultaneous occurrence of AD-related neuronal injury and concomitant Lewy body pathology, which may elevate and

  5. Dual-polarization C-band weather radar algorithms for rain rate estimation and hydrometeor classification in an alpine region

    Directory of Open Access Journals (Sweden)

    H. Paulitsch

    2009-03-01

    Full Text Available Dual polarization is becoming the standard for new weather radar systems. In contrast to conventional weather radars, where the reflectivity is measured in one polarization plane only, a dual polarization radar provides transmission in either horizontal, vertical, or both polarizations while receiving both the horizontal and vertical channels simultaneously. Since hydrometeors are often far from being spherical, the backscatter and propagation are different for horizontal and vertical polarization. Comparing the reflected horizontal and vertical power returns and their ratio and correlation, information on size, shape, and material density of cloud and precipitation particles can be obtained. The use of polarimetric radar variables can therefore increase the accuracy of the rain rate estimation compared to standard Z-R relationships of non-polarimetric radars. It is also possible to derive the type of precipitation from dual polarization parameters, although this is not an easy task, since there is no clear discrimination between the different values. Fuzzy logic approaches have been shown to work well with overlapping conditions and imprecisely defined class output.

    In this paper the implementation of different polarization algorithms for the new Austrian weather radar on Mt. Valluga is described, and first results from operational use are presented. This study also presents first observations of rain events in August 2007 during the test run of the radar. Further, the designated rain rate estimation and hydrometeor classification algorithms are explained.

  6. Influence of the mass flow rate of secondary air on the gas/particle flow characteristics in the near-burner region of a double swirl flow burner

    Energy Technology Data Exchange (ETDEWEB)

    Jing, J.P.; Li, Z.Q.; Wang, L.; Chen, Z.C.; Chen, L.Z.; Zhang, F.C. [Harbin Institute of Technology, Harbin (China)

    2011-06-15

    The influence of the mass flow rate of secondary air on the gas/particle flow characteristics of a double swirl flow burner, in the near-burner region, was measured by a three-component particle-dynamics anemometer, in conjunction with a gas/particle two-phase test facility. Velocities, particle volume flux profiles, and normalized particle number concentrations were obtained. The relationship between the gas/particle flows and the combustion characteristics of the burners was discussed. For different mass flow rates of secondary air, annular recirculation zones formed only in the region of r/d=0.3-0.6 at x/d=0.1-0.3. With an increasing mass flow rate of secondary air, the peaks of the root mean square (RMS) axial fluctuating velocities, radial mean velocities, RMS radial fluctuating velocities, and tangential velocities all increased, while the recirculation increased slightly. There was a low particle volume flux in the central zone of the burner. At x/d=0.1-0.7, the profiles of particle volume flux had two peaks in the secondary air flow zone near the wall. With an increasing mass flow rate of secondary air, the peak of particle volume flux in the secondary air flow zone decreased, but the peak of particle volume flux near the wall increased. In section x/d=0.1-0.5, the particle diameter in the central zone of the burner was always less than the particle diameter at other locations.

  7. [Effects of nitrogen fertilization rate and planting density on cotton biomass and nitrogen accumulation in extremely early mature cotton region of Northeast China].

    Science.gov (United States)

    Wang, Zi-Sheng; Xu, Min; Zhang, Guo-Wei; Jin, Lu-Lu; Shan, Ying; Wu, Xiao-Dong; Zhou, Zhi-Guo

    2011-12-01

    Taking two cotton cultivars Liaomian 19 and NuCOTN 33B with different growth periods as test materials, a field experiment was conducted to study the effects of different nitrogen fertilization rates (0, 240 and 480 kg N x hm(-2)) and different planting densities (75000, 97500 and 120000 plants x hm(-2)) on the cotton biomass, nitrogen accumulation, and accumulative nitrogen utilization in the planting region of extremely early mature cotton in Northeast China. The dynamics of cotton biomass and nitrogen accumulation of the two cultivars with their growth process followed Logistic model. Both nitrogen fertilization rate and planting density had significant effects on the cotton nitrogen accumulation dynamics and the cotton yield and quality. In all treatments, the beginning time of rapid accumulation of nitrogen was about 13 d earlier than that of biomass. In treatment plant density 97500 plants x hm(-2) and nitrogen fertilization rate 240 kg x hm(-2), the eigenvalues of the dynamic accumulation models of nitrogen and biomass for the two cultivars were most harmonious, lint yield was the highest, fiber quality was the best, and accumulative nitrogen utilization efficiency was the highest. In the study region, the earlier beginning time of rapid accumulation of nitrogen and biomass and their higher accumulation rates were benefit to the formation of higher cotton yield.

  8. Household solid waste generation rate and physical composition analysis: case of Sekondi-Takoradi Metropolis in the western region, Ghana

    Directory of Open Access Journals (Sweden)

    Eugene Atta Nyankson

    2015-06-01

    Full Text Available Sekondi-Takoradi Metropolis, one of the rapidly expanding cities of Ghana has been facing serious problems with solid waste management. This is mainly due to the lack of available information about the types and quantity of solid waste generation in the area. Hence, the objective of this study was to determine the rate of household solid waste generation and its composition in the aforesaid city. The methodology and procedures for this study were derived from the Standard Test Method for Determination of the Composition of Unprocessed MSW (ASTM D 5231-92. All samples were hand sorted into 6 waste categories (paper, plastic, organics, metals, glass, and other waste. The study revealed that by weight, organic wastes constitutes the largest proportion of household solid waste (38% followed by 19% plastics, 7% papers, 4% metals, 4% glass and 28% other wastes (comprising of sand, stones, ash, inert substances. The rate of daily waste generation per capita in the low, middle and high income households were 0.27±0.19, 0.4±0.19 and 0.58±0.24 kg/cap/day, respectively. The study revealed that there is no waste treatment or recovery facility established within the metropolis hence no significant waste recovery and reuse activities exist. The study showed that more than 38 % of the waste generated in Sekondi-Takoradi Metropolis is decomposable organic matter that can be re-used through composting as well as 34% of the waste having recycling potential thereby considerably mitigating the solid waste problem. DOI: http://dx.doi.org/10.3126/ije.v4i2.12644 International Journal of Environment Vol.4(2 2015: 221-235

  9. [Cost-utility analysis on universal childhood hepatitis A vaccination in regions with different anti-HAV prevalence rates of China].

    Science.gov (United States)

    Pan, Xin-juan; Feng, Yan-ming; Zhuang, Gui-hua

    2012-08-01

    To explore the inputs and outputs of areas with different anti-HAV prevalence rates on universal childhood vaccination, and to provide a scientific basis for the formulation of the immunization strategy. Since hepatitis A vaccination was scheduled at 12 and 18 months of age for all the healthy children, a single cohort including 1 000 000 individuals was formed in 2009, using the Chinese inactivated vaccine. Decision analysis was used to build Markov-decision tree model. The universal childhood hepatitis A vaccination was compared with non-vaccination group to evaluate the number of symptomatic infection, hospitalization, death, quality-adjusted life years (QALYs) lost, and the incremental cost-utility from the health system and the societal perspectives. Outcomes of the vaccination for the next 70 years were also predicted. The process of analysis was run separately in five regions defined by the anti-HAV prevalence rates (around 50%, 50% - 69%, 70% - 79%, 80% - 89% and > 90%). Sensitivity analysis was performed to test the stability or reliability of the results, and to identify sensitive variables. The study projected that, in the lowest, lower, and intermediate infection regions, the cost and output indicators of universal childhood hepatitis A vaccination were all lower than non-vaccinated group. Universal vaccination could gain QALYs and save both costs from the health system or the society. In the regions with higher infection rate, the output indicators of universal childhood hepatitis A vaccination were lower than in those non-vaccinated groups, except for the number of death due to hepatitis A, which had a 20 cases of increase. The model also predicted that in the highest infected region, universal vaccination would increase 4 560 814 and 5 840 430 RMB Yuan in the total costs from both the health system and the societies, respectively, when compared to the non-vaccination groups. Universal vaccination would also decrease the numbers of symptomatic

  10. Detection of Left Ventricular Regional Function in Asymptomatic Children with beta-Thalassemia Major by Longitudinal Strain and Strain Rate Imaging

    Directory of Open Access Journals (Sweden)

    Ali Bay

    2013-09-01

    Full Text Available Objective: Cardiac failure due to iron overload remains the most common cause of death in patients with beta-thalassemia major. This study aimed to evaluate myocardial function in children with beta-thalassemia major using standard echocardiography technique and strain rate imaging. Materials and Methods: Conventional echocardiographic analysis, tissue velocity imaging, and strain/strain rate imaging of the left ventricle were evaluated in 48 children with beta thalassemia major (19 girls, 29 boys; 8.39±4.05 years and 22 healthy children (11 girls, 11 boys; 8±3.72 years. Results: Conventional echocardiographic examinations revealed that beta-thalassemia patients had larger left ventricular end-systolic diameter, end-diastolic and end-systolic volume, left ventricular mass index, and mitral early/late diastolic flow velocity ratio (p<0.05. Strain and strain rate imaging study of the basal lateral wall of the left ventricle was higher in patients than in controls, at p=0.035 and p=0.008, respectively. Conclusion: We found that superior systolic strain and strain rate imaging of the left ventricle indicated the presence of regional systolic function in the left ventricular wall. We suggest that left ventricle volume and mass index parameters might be more sensitive than the other conventional and strain/strain rate imaging parameters during childhood. However, the adulthood strain and strain rate imaging values may be lower than controls, exceeding the critical level of iron overload.

  11. Notwithstanding High Prevalence of Overweight and Obesity, Smoking Remains the Most Important Factor in Poor Self-rated Health and Hospital Use in an Australian Regional Community

    Directory of Open Access Journals (Sweden)

    Helen Mary Haines

    2017-08-01

    Full Text Available Objective: To classify a rural community sample by their modifiable health behaviours and identify the prevalence of chronic conditions, poor self-rated health, obesity and hospital use. Method: Secondary analysis of a cross- sectional self-report questionnaire in the Hume region of Victoria, Australia. Cluster analysis using the two-step method was applied to responses to health behaviour items. Results: 1,259 questionnaires were completed. Overall 63% were overweight or obese. Three groups were identified: ‘Healthy Lifestyle’ (63%, ‘Non Smoking, Unhealthy Lifestyle’ (25% and ‘Smokers’ (12%. ‘Healthy lifestyle’ were older and more highly educated than the other two groups while ‘Non Smoking, Unhealthy Lifestyle’ were more likely to be obese. ‘Smokers’ had the highest rate of poor self-rated health. Prevalence of chronic conditions was similar in each group (>20%. ‘Smokers’ were twice as likely to have had two or more visits to hospital in the preceding year even after adjustment for age, gender and education. Conclusion: High rates of overweight and obesity were identified but ‘Smokers’ were at the greatest risk for poor self-rated health and hospitalisation. Implications for Public Health: Within an environment of high rates of chronic ill health and obesity, primary care clinicians and public health policy makers must maintain their vigilance in encouraging people to quit smoking.

  12. Physical models of spall zone ground motions and the determination of spatial decay rates. Los Alamos Source Region Project

    Energy Technology Data Exchange (ETDEWEB)

    Stump, B.W. [Southern Methodist Univ., Dallas, TX (United States). Dept. of Geological Sciences; Weaver, T.A. [Los Alamos National Lab., NM (United States)

    1992-01-24

    Spall, the tensile failure of near-surface layers, which is observed above contained explosions, has been identified as a possible secondary seismic source contributing to teleseismic and regional signals. The relative importance of this secondary source can be constrained if the motion field in the spall zone is characterized. Spall zone motions from nuclear explosions detonated above the water table at Pahute Mesa are analyzed to develop these models. Acceleration, velocity, displacement, and dwell time measurements are made from gauges placed directly above the explosion, most often at the free surface. Decay of peak motions are strongly affected by the free surface with little change in amplitude out to a free surface range of 100 m/kt{sup l/3} followed by rapid decay beyond. Free surface interactions are assessed with first-order elastic spherical wave calculations that match observed peak velocity decays. These results indicate that the spall zone motions may be strongly affected by the scaled depth of burial of the explosion. Spall zone velocities, displacements and dwell times are compared for consistency with a gravitational model. The data is in agreement with the functional form of theoretical models although observed displacements may be as much as a factor of two to four greater than the model predicts for observed velocities and dwell times. These differences may reflect the continuous nature of the spall process and/or the role of material strength in these phenomena.

  13. Runoff, nitrogen (N) and phosphorus (P) losses from purple slope cropland soil under rating fertilization in Three Gorges Region.

    Science.gov (United States)

    Bouraima, Abdel-Kabirou; He, Binghui; Tian, Taiqiang

    2016-03-01

    Soil erosion along with soil particles and nutrients losses is detrimental to crop production. We carried out a 5-year (2010 to 2014) study to characterize the soil erosion and nitrogen and phosphorus losses caused by rainfall under different fertilizer application levels in order to provide a theoretical evidence for the agricultural production and coordinate land management to improve ecological environment. The experiment took place under rotation cropping, winter wheat-summer maize, on a 15° slope purple soil in Chongqing (China) within the Three Gorges Region (TGR). Four treatments, control (CK) without fertilizer, combined manure with chemical fertilizer (T1), chemical fertilization (T2), and chemical fertilizer with increasing fertilization (T3), were designed on experimental runoff plots for a long-term observation aiming to study their effects on soil erosion and nutrients losses. The results showed that fertilization reduced surface runoff and nutrient losses as compared to CK. T1, T2, and T3, compared to CK, reduced runoff volume by 35.7, 29.6, and 16.8 %, respectively and sediment yield by 40.5, 20.9, and 49.6 %, respectively. Regression analysis results indicated that there were significant relationships between soil loss and runoff volume in all treatments. The combined manure with chemical fertilizer (T1) treatment highly reduced total nitrogen and total phosphorus losses by 41.2 and 33.33 %, respectively as compared with CK. Through this 5-year experiment, we can conclude that, on the sloping purple soil, the combined application of manure with fertilizer is beneficial for controlling runoff sediments losses and preventing soil erosion.

  14. Estimate of regional groundwater recharge rate in the Central Haouz Plain, Morocco, using the chloride mass balance method and a geographical information system

    Science.gov (United States)

    Ait El Mekki, Ouassil; Laftouhi, Nour-Eddine; Hanich, Lahoucine

    2017-07-01

    Located in the extreme northwest of Africa, the Kingdom of Morocco is increasingly affected by drought. Much of the country is characterised by an arid to semi-arid climate and the demand for water is considerably higher than the supply, particularly on the Haouz Plain in the centre of the country. The expansion of agriculture and tourism, in addition to industrial development and mining, have exacerbated the stress on water supplies resulting in drought. It is therefore necessary to adopt careful management practices to preserve the sustainability of the water resources in this region. The aquifer recharge rate in the piedmont region that links the High Atlas and the Central Haouz Plain was estimated using the chloride mass balance hydrochemical method, which is based on the relationship between the chloride concentrations in groundwater and rainwater. The addition of a geographical information system made it possible to estimate the recharge rate over the whole 400 km2 of the study area. The results are presented in the form of a map showing the spatialized recharge rate, which ranges from 13 to 100 mm/year and the recharge percentage of the total rainfall varies from 3 to 25 % for the hydrological year 2011-2012. This approach will enable the validation of empirical models covering areas >6200 km2, such as the Haouz nappe.

  15. A new interpretation of deformation rates in the Snake River Plain and adjacent basin and range regions based on GPS measurements

    Energy Technology Data Exchange (ETDEWEB)

    S.J. Payne; R. McCaffrey; R.W. King; S.A. Kattenhorn

    2012-04-01

    We evaluate horizontal Global Positioning System (GPS) velocities together with geologic, volcanic, and seismic data to interpret extension, shear, and contraction within the Snake River Plain and the Northern Basin and Range Province, U.S.A. We estimate horizontal surface velocities using GPS data collected at 385 sites from 1994 to 2009 and present an updated velocity field within the Stable North American Reference Frame (SNARF). Our results show an ENE-oriented extensional strain rate of 5.9 {+-} 0.7 x 10{sup -9} yr{sup -1} in the Centennial Tectonic belt and an E-oriented extensional strain rate of 6.2 {+-} 0.3 x 10{sup -9} yr{sup -1} in the Intermountain Seismic belt combined with the northern Great Basin. These extensional strain rates contrast with the regional north-south contraction of -2.6 {+-} 1.1 x 10{sup -9} yr{sup -1} calculated in the Snake River Plain and Owyhee-Oregon Plateau over a 125 x 650 km region. Tests that include dike-opening reveal that rapid extension by dike intrusion in volcanic rift zones does not occur in the Snake River Plain at present. This slow internal deformation in the Snake River Plain is in contrast to the rapidly-extending adjacent Basin and Range provinces and implies shear along boundaries of the Snake River Plain. We estimate right-lateral shear with slip rates of 0.5-1.5 mm/yr along the northwestern boundary adjacent to the Centennial Tectonic belt and left-lateral oblique extension with slip rates of <0.5 to 1.7 mm/yr along the southeastern boundary adjacent to the Intermountain Seismic belt. The fastest lateral shearing occurs near the Yellowstone Plateau where strike-slip focal mechanisms and faults with observed strike-slip components of motion are documented. The regional GPS velocity gradients are best fit by nearby poles of rotation for the Centennial Tectonic belt, Idaho batholith, Snake River Plain, Owyhee-Oregon Plateau, and central Oregon, indicating that clockwise rotation is driven by extension to the

  16. First trimester Down's syndrome screening shows high detection rate for trisomy 21, but poor performance in structural abnormalities--regional outcome results.

    Science.gov (United States)

    Rissanen, Anne; Niemimaa, Marko; Suonpää, Mikko; Ryynänen, Markku; Heinonen, Seppo

    2007-01-01

    To evaluate whether first trimester screening markers are altered in pregnancies affected both by other chromosomal defects than trisomy 21 and structural anomalies and whether it is possible to detect these pregnancies by combined ultrasound and biochemical screening test. Altogether 4,776 singleton pregnancies underwent first trimester screening. Of them, 3,101 women were screened using a combination of maternal serum free hCG, pregnancy-associated plasma protein A and nuchal translucency and 1,361 women with first trimester biochemistry without ultrasound. Nuchal translucency screening was performed between the 11th and 13+6th gestational weeks, and biochemistry 1-2 weeks earlier. Using a fixed cut-off rate of 1:250 for Down's syndrome, the detection rate of trisomies 21, 18 and 13 were 92, 67 and 0%, respectively. All open defects, 85% of cardiac defects and other minor defects were not detected in first trimester screening. Majority of these structural abnormalities occurred in women under 35 years of age. First trimester Down's syndrome screening is effective in trisomy screening, but its performance in structural abnormalities is low, when used as a part of routine clinical practice. We conclude that it is too early to drop second trimester screening ultrasound entirely from antenatal care programs if a high detection rate is to be achieved also in structural defects.

  17. A change in coral extension rates and stable isotopes after El Niño-induced coral bleaching and regional stress events

    Science.gov (United States)

    Hetzinger, S.; Pfeiffer, M.; Dullo, W.-Chr.; Zinke, J.; Garbe-Schönberg, D.

    2016-09-01

    Coral reefs are biologically diverse ecosystems threatened with effective collapse under rapid climate change, in particular by recent increases in ocean temperatures. Coral bleaching has occurred during major El Niño warming events, at times leading to the die-off of entire coral reefs. Here we present records of stable isotopic composition, Sr/Ca ratios and extension rate (1940-2004) in coral aragonite from a northern Venezuelan site, where reefs were strongly impacted by bleaching following the 1997-98 El Niño. We assess the impact of past warming events on coral extension rates and geochemical proxies. A marked decrease in coral (Pseudodiploria strigosa) extension rates coincides with a baseline shift to more negative values in oxygen and carbon isotopic composition after 1997-98, while a neighboring coral (Siderastrea siderea) recovered to pre-bleaching extension rates simultaneously. However, other stressors, besides high temperature, might also have influenced coral physiology and geochemistry. Coastal Venezuelan reefs were exposed to a series of extreme environmental fluctuations since the mid-1990s, i.e. upwelling, extreme rainfall and sediment input from landslides. This work provides important new data on the potential impacts of multiple regional stress events on coral isotopic compositions and raises questions about the long-term influence on coral-based paleoclimate reconstructions.

  18. Quantifying uranium transport rates and storage of fluvially eroded mine tailings from a historic mine site in the Grand Canyon Region

    Science.gov (United States)

    Skalak, K.; Benthem, A. J.; Walton-Day, K. E.; Jolly, G.

    2015-12-01

    The Grand Canyon region contains a large number of breccia pipes with economically viable uranium, copper, and silver concentrations. Mining in this region has occurred since the late 19th century and has produced ore and waste rock having elevated levels of uranium and other contaminants. Fluvial transport of these contaminants from mine sites is a possibility, as this arid region is susceptible to violent storms and flash flooding which might erode and mobilize ore or waste rock. In order to assess and manage the risks associated with uranium mining, it is important to understand the transport and storage rates of sediment and uranium within the ephemeral streams of this region. We are developing a 1-dimensional sediment transportation model to examine uranium transport and storage through a typical canyon system in this region. Our study site is Hack Canyon Mine, a uranium and copper mine site, which operated in the 1980's and is currently experiencing fluvial erosion of its waste rock repository. The mine is located approximately 40km upstream from the Colorado River and is in a deep, narrow canyon with a small watershed. The stream is ephemeral for the upper half of its length and sediment is primarily mobilized during flash flood events. We collected sediment samples at 110 locations longitudinally through the river system to examine the distribution of uranium in the stream. Samples were sieved to the sand size and below fraction (system to determine where uranium is preferentially stored in canyon systems. This information will quantify the downstream transport of constituents associated with the Hack Canyon waste rock and contribute to understanding the risks associated with fluvial mobilization of uranium mine waste.

  19. Non-permanent GPS data for regional-scale kinematics: reliable deformation rate before the 6 April, 2009, earthquake in the L'Aquila area

    Directory of Open Access Journals (Sweden)

    Fabiana Loddo

    2010-05-01

    Full Text Available A GPS-based geodetic study at a regional scale requires the availability of a dense network that is characterized by 10 km to 30 km spacing, typically followed in a few continuous GPS stations (CGPSs and several non-permanent GPS stations (NPSs. As short observation times do not allow adequate noise modeling, NPS data need specific processing where the main differences between NPSs and CGPSs are taken into account: primarily time-series length and antenna repositioning error. The GPS data collected in the 1999-2007 time-span from non-permanent measurement campaigns in the central Apennine area (Italy that was recently hit by the Mw 6.3 L'Aquila earthquake (April 6, 2009 are here further analyzed to compute a reliable strain-rate field at a regional scale. Moreover, areas characterized by different kinematics are recognized, and a complete characterization of the regional-scale kinematics is attempted. These new data can be interpreted as indicators from the viewpoint of seismic risk assessment.

  20. Impacts of uncertainty in AVOC emissions on the summer RO x budget and ozone production rate in the three most rapidly-developing economic growth regions of China

    Science.gov (United States)

    Wang, Feng; An, Junling; Li, Ying; Tang, Yujia; Lin, Jian; Qu, Yu; Chen, Yong; Zhang, Bing; Zhai, Jing

    2014-11-01

    High levels of uncertainty in non-methane volatile organic compound (NMVOC) emissions in China could lead to significant variation in the budget of the sum of hydroxyl (OH) and peroxy (HO2, RO2) radicals (RO x = OH + HO2 + RO2) and the ozone production rate [P(O3)], but few studies have investigated this possibility, particularly with three-dimensional air quality models. We added diagnostic variables into the WRF-Chem model to assess the impact of the uncertainty in anthropogenic NMVOC (AVOC) emissions on the RO x budget and P(O3) in the Beijing-Tianjin-Hebei region, Yangtze River Delta, and Pearl River Delta of China. The WRF-Chem simulations were compared with satellite and ground observations, and previous observation-based model studies. Results indicated that 68% increases (decreases) in AVOC emissions produced 4%-280% increases (2%-80% decreases) in the concentrations of OH, HO2, and RO2 in the three regions, and resulted in 35%-48% enhancements (26%-39% reductions) in the primary RO x production and ˜ 65% decreases (68%-73% increases) of the P(O3) in Beijing, Shanghai, and Guangzhou. For the three cities, the two largest contributors to the RO x production rate were the reaction of O1D + H2O and photolysis of HCHO, ALD2, and others; the reaction of OH + NO2 (71%-85%) was the major RO x sink; and the major contributor to P(O3) was the reaction of HO2 + NO (˜ 65%). Our results showed that AVOC emissions in 2006 from Zhang et al. (2009) have been underestimated by ˜ 68% in suburban areas and by > 68% in urban areas, implying that daily and hourly concentrations of secondary organic aerosols and inorganic aerosols could be substantially underestimated, and cloud condensation nuclei could be underestimated, whereas local and regional radiation was overestimated.

  1. Validity of using a 3-dimensional PET scanner during inhalation of 15O-labeled oxygen for quantitative assessment of regional metabolic rate of oxygen in man.

    Science.gov (United States)

    Hori, Yuki; Hirano, Yoshiyuki; Koshino, Kazuhiro; Moriguchi, Tetsuaki; Iguchi, Satoshi; Yamamoto, Akihide; Enmi, Junichiro; Kawashima, Hidekazu; Zeniya, Tsutomu; Morita, Naomi; Nakagawara, Jyoji; Casey, Michael E; Iida, Hidehiro

    2014-09-21

    Use of 15O labeled oxygen (15O2) and positron emission tomography (PET) allows quantitative assessment of the regional metabolic rate of oxygen (CMRO2) in vivo, which is essential to understanding the pathological status of patients with cerebral vascular and neurological disorders. The method has, however, been challenging, when a 3D PET scanner is employed, largely attributed to the presence of gaseous radioactivity in the trachea and the inhalation system, which results in a large amount of scatter and random events in the PET assessment. The present study was intended to evaluate the adequacy of using a recently available commercial 3D PET scanner in the assessment of regional cerebral radioactivity distribution during an inhalation of 15O2. Systematic experiments were carried out on a brain phantom. Experiments were also performed on a healthy volunteer following a recently developed protocol for simultaneous assessment of CMRO2 and cerebral blood flow, which involves sequential administration of 15O2 and C15O2. A particular intention was to evaluate the adequacy of the scatter-correction procedures. The phantom experiment demonstrated that errors were within 3% at the practically maximum radioactivity in the face mask, with the greatest radioactivity in the lung. The volunteer experiment demonstrated that the counting rate was at peak during the 15O gas inhalation period, within a verified range. Tomographic images represented good quality over the entire FOV, including the lower part of the cerebral structures and the carotid artery regions. The scatter-correction procedures appeared to be important, particularly in the process to compensate for the scatter originating outside the FOV. Reconstructed images dramatically changed if the correction was carried out using inappropriate procedures. This study demonstrated that accurate reconstruction could be obtained when the scatter compensation was appropriately carried out. This study also suggested the

  2. Rates and factors associated with major modifications to first-line combination antiretroviral therapy: results from the Asia-Pacific region.

    Directory of Open Access Journals (Sweden)

    Stephen Wright

    Full Text Available BACKGROUND: In the Asia-Pacific region many countries have adopted the WHO's public health approach to HIV care and treatment. We performed exploratory analyses of the factors associated with first major modification to first-line combination antiretroviral therapy (ART in resource-rich and resource-limited countries in the region. METHODS: We selected treatment naive HIV-positive adults from the Australian HIV Observational Database (AHOD and the TREAT Asia HIV Observational Database (TAHOD. We dichotomised each country's per capita income into high/upper-middle (T-H and lower-middle/low (T-L. Survival methods stratified by income were used to explore time to first major modification of first-line ART and associated factors. We defined a treatment modification as either initiation of a new class of antiretroviral (ARV or a substitution of two or more ARV agents from within the same ARV class. RESULTS: A total of 4250 patients had 961 major modifications to first-line ART in the first five years of therapy. The cumulative incidence (95% CI of treatment modification was 0.48 (0.44-0.52, 0.33 (0.30-0.36 and 0.21 (0.18-0.23 for AHOD, T-H and T-L respectively. We found no strong associations between typical patient characteristic factors and rates of treatment modification. In AHOD, relative to sites that monitor twice-yearly (both CD4 and HIV RNA-VL, quarterly monitoring corresponded with a doubling of the rate of treatment modifications. In T-H, relative to sites that monitor once-yearly (both CD4 and HIV RNA-VL, monitoring twice-yearly corresponded to a 1.8 factor increase in treatment modifications. In T-L, no sites on average monitored both CD4 & HIV RNA-VL concurrently once-yearly. We found no differences in rates of modifications for once- or twice-yearly CD4 count monitoring. CONCLUSIONS: Low-income countries tended to have lower rates of major modifications made to first-line ART compared to higher-income countries. In higher

  3. Investigating the timing of origin and evolutionary processes shaping regional species diversity: Insights from simulated data and neotropical butterfly diversification rates.

    Science.gov (United States)

    Matos-Maraví, Pável

    2016-07-01

    Different diversification scenarios have been proposed to explain the origin of extant biodiversity. However, most existing meta-analyses of time-calibrated phylogenies rely on approaches that do not quantitatively test alternative diversification processes. Here, I highlight the shortcomings of using species divergence ranks, which is a method widely used in meta-analyses. Divergence ranks consist of categorizing cladogenetic events to certain periods of time, typically to either Pleistocene or to pre-Pleistocene ages. This approach has been claimed to shed light on the origin of most extant species and the timing and dynamics of diversification in any biogeographical region. However, interpretations drawn from such method often confound two fundamental questions in macroevolutionary studies, tempo (timing of evolutionary rate shifts) and mode ("how" and "why" of speciation). By using simulated phylogenies under four diversification scenarios, constant-rate, diversity-dependence, high extinction, and high speciation rates in the Pleistocene, I showed that interpretations based on species divergence ranks might have been seriously misleading. Future meta-analyses of dated phylogenies need to be aware of the impacts of incomplete taxonomic sampling, tree topology, and divergence time uncertainties, as well as they might be benefited by including quantitative tests of alternative diversification models that acknowledge extinction and diversity dependence.

  4. A longitudinal study of the relationship between personality traits and the annual rate of volume changes in regional gray matter in healthy adults.

    Science.gov (United States)

    Taki, Yasuyuki; Thyreau, Benjamin; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Wu, Kai; Kawashima, Ryuta; Fukuda, Hiroshi

    2013-12-01

    To investigate whether personality traits affect the rate of decline of gray matter volume, we analyzed the relationships between personality traits and the annual rate of changes of gray matter volume in 274 healthy community dwelling subjects with a large age range by applying a longitudinal design over 6 years, using brain magnetic resonance images (MRI) and the Revised NEO Personality Inventory (NEO-PI-R) at baseline. Brain MRI data were processed using voxel-based morphometry with a custom template by applying the DARTEL diffeomorphic registration tool. For each subject, we used NEO-PI-R to evaluate the five major personality traits, including neuroticism, extraversion, openness, agreeableness, and conscientiousness. The results show that the annual rate of change in regional gray matter volume in the right inferior parietal lobule was correlated significantly and negatively with a personality of openness, which is known to be related to intellect, intellectual curiosity, and creativity adjusting for age, gender, and intracranial volume. This result indicates that subjects with a personality trait of less openness have an accelerated loss of gray matter volume in the right inferior parietal lobule, compared with subjects with a personality trait of more openness. Because the right inferior parietal lobule is involved in higher cognitive function such as working memory and creativity, a personality trait of openness is thought to be important for preserving gray matter volume and cognitive function of the right inferior parietal lobule in healthy adults.

  5. Selected Aspects of the Copenhagen Economics Study on Reduced VAT Rates in the Current Conditions of the Moravian-Silesian Region

    Directory of Open Access Journals (Sweden)

    Kateřina Randová

    2012-01-01

    Full Text Available This paper deals with a long-debated issue of the application of value added tax rates to labour-intensive services. The level of value added tax rates has a dominant influence on the tax liability of suppliers of these services and subsequently on the amount of available funds that they could use for development of their business. The aim of this paper is a presentation of results of the student grant Quantification of Impacts of Application of Reduced Value Added Tax Rate to Locally Supplied Services on the Suppliers of these Services”, which is focused on selected aspects of the “Study on reduced VAT applied to goods and services in the Member States of the European Union” in the conditions of the providers of these services from the Moravian-Silesian Region. For this paper the methods of regression analysis and analysis of variance – ANOVA were used. The deductive method and method of analysis have also been used.

  6. Effect of Residue Nitrogen Concentration and Time Duration on Carbon Mineralization Rate of Alfalfa Residues in Regions with Different Climatic Conditions

    Directory of Open Access Journals (Sweden)

    saeid shafiei

    2017-01-01

    Full Text Available Introduction Various factors like climatic conditions, vegetation, soil properties, topography, time, plant residue quality and crop management strategies affect the decomposition rate of organic carbon (OC and its residence time in soil. Plant residue management concerns nutrients recycling, carbon recycling in ecosystems and the increasing CO2 concentration in the atmosphere. Plant residue decomposition is a fundamental process in recycling of organic matter and elements in most ecosystems. Soil management, particularly plant residue management, changes soil organic matter both qualitatively and quantitatively. Soil respiration and carbon loss are affected by soil temperature, soil moisture, air temperature, solar radiation and precipitation. In natural agro-ecosystems, residue contains different concentrations of nitrogen. It is important to understand the rate and processes involved in plant residue decomposition, as these residues continue to be added to the soil under different weather conditions, especially in arid and semi-arid climates. Material and methods Organic carbon mineralization of alfalfa residue with different nitrogen concentrations was assessed in different climatic conditions using split-plot experiments over time and the effects of climate was determined using composite analysis. The climatic conditions were classified as warm-arid (Jiroft, temperate arid (Narab and cold semi-arid (Sardouiyeh using cluster analysis and the nitrogen (N concentrations of alfalfa residue were low, medium and high. The alfalfa residue incubated for four different time periods (2, 4, 6 and 8 months. The dynamics of organic carbon in different regions measured using litter bags (20×10 cm containing 20 g alfalfa residue of 2-10 mm length which were placed on the soil surface. Results and discussion The results of this study showed that in a warm-arid (Jiroft, carbon loss and the carbon decomposition rate constant were low in a cold semi

  7. The impact of growth rate on the results of growth and slaughter traits of young crossbred boars in Poland in Bydgoszcz Breeding Region

    Directory of Open Access Journals (Sweden)

    Jerzy NOWACHOWICZ

    2012-01-01

    Full Text Available There was analysed the impact of growth rate on the results of growth and slaughter traits of 3917 young crossbred boars performance tested in years 2004-2008 in Poland in The Bydgoszcz Breeding Region. They came from 8 following crossing variants, where sow’s breed was given in a first position and boar’s breed in a second position: Hampshire x Belgian Landrace (H x BL, Hampshire x Duroc (H x D, Hampshire x Pietrain (H x P, Duroc x Hampshire (D x H, Duroc x Pietrain (D x P, Pietrain x Hampshire (P x H, Pietrain x Duroc (P x D and Line 990 x Pietrain (990 x P. The impact of growth rate on the results’ formation in the range of tested traits noted in different degrees. It was the most visible in the growth traits (age and body weight and the performance test selection index and less visible in the slaughter traits, among which the most visible in case of the backfat thickness measured in P2 and P4 points and then in the meat content and the height of loin eye. In the analyzed years tested young crossbred boars of the high growth rate, i.e. of high daily gain of body weight standardized on the 180th day of life were younger and generally obtained higher body weight and higher performance test selection index and in the majority of cases, where the statistically significant differences were proved, had thinner backfat in the P2 and P4 points and had lower meat content and the higher height of loin eye as compared to the animals of low growth rate.

  8. Fiscal 1999 achievement report on regional consortium research and development project. Regional consortium research on energy (Research and development of biofuel production using highly functional bioreactor - 2nd year); 1999 nendo kokino bio reactor ni yoru bio nenryo seisan ni kansuru kenkyu kaihatsu seika hokokusho (dai 2 nendo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Microbes capable of a high biodiesel fuel (BDF) yield from moisture-containing oils assumedly waste oil are investigated. Lipase attributed to Rhizopus oryzae exhibits a high reaction rate of not lower than 90%. The process functions even when microbes are immobilized by BSPs. BDF does not affect driving performance, and black smoke is reduced. A process basic to industrial production is developed by use of a fixed bed reactor. In the production of ethanol from starch thanks to plural kinds of glucoamylase producing yeast, ethanol is produced at a rate of 7-8% under microaerophilic conditions in both proliferation and fermentation periods, which means a success achieved in growing arming yeast equipped with enhanced functions. A 20-liter class bench plant is installed and immobilization by BSPs is tested, when no problem is detected. In a reaction involving these immobilized microbes, a reaction rate near 16% is achieved. In the production of ethanol by yeast immobilized by BSPs, use of a fuzzy control system is studied, and it is found that prolonged stability is available when glucose concentration is sustained at 10-20g/liter. (NEDO)

  9. Knowledge, attitudes and practices of contraception by HIV positive women followed in a Cameroon region with high illiteracy rate: a cross sectional study.

    Science.gov (United States)

    Nkwabong, Elie; Minda, Véronique; Fomulu, Joseph Nelson

    2015-01-01

    To evaluate the knowledge, attitude and practices of contraception by HIV positive women. This cross-sectional descriptive study was carried out in the Maroua Regional Hospital (Cameroon) from September 1(st), 2012 to February 28(th), 2013. All HIV positive women aged between 15 and 49 years who were received in the HIV clinic were recruited. The variables recorded included maternal age, number of living children, marital status, religion, the educational level, and the use of antiretroviral treatment (HAART), the knowledge, attitude and practice of contraception. Analyses were done using SPSS 18.0. Fisher exact test was used for comparison. The level of significance was P illiteracy rate. Therefore, all contraceptive methods should be made available to these women. Towards these women and their partner(s), more emphasis should be made on the systematic condom use even when using other contraceptive methods (dual protection).

  10. HMI Data Driven Magnetohydrodynamic Model Predicted Active Region Photospheric Heating Rates: Their Scale Invariant, Flare Like Power Law Distributions, and Their Possible Association With Flares

    Science.gov (United States)

    Goodman, Michael L.; Kwan, Chiman; Ayhan, Bulent; Shang, Eric L.

    2017-01-01

    A data driven, near photospheric, 3 D, non-force free magnetohydrodynamic model predicts time series of the complete current density, and the resistive heating rate Q at the photosphere in neutral line regions (NLRs) of 14 active regions (ARs). The model is driven by time series of the magnetic field B observed by the Helioseismic and Magnetic Imager on the Solar Dynamics Observatory (SDO) satellite. Spurious Doppler periods due to SDO orbital motion are filtered out of the time series for B in every AR pixel. Errors in B due to these periods can be significant. The number of occurrences N(q) of values of Q > or = q for each AR time series is found to be a scale invariant power law distribution, N(Q) / Q-s, above an AR dependent threshold value of Q, where 0.3952 or = E obeys the same type of distribution, N(E) / E-S, above an AR dependent threshold value of E, with 0.38 < or approx. S < or approx. 0.60, also with little variation among ARs. Within error margins the ranges of s and S are nearly identical. This strong similarity between N(Q) and N(E) suggests a fundamental connection between the process that drives coronal flares and the process that drives photospheric NLR heating rates in ARs. In addition, results suggest it is plausible that spikes in Q, several orders of magnitude above background values, are correlated with times of the subsequent occurrence of M or X flares.

  11. Exploring disparities in incidence and mortality rates of breast and gynecologic cancers according to the Human Development Index in the Pan-American region.

    Science.gov (United States)

    Martínez-Mesa, J; Werutsky, G; Michiels, S; Pereira Filho, C A S; Dueñas-González, A; Zarba, J J; Mano, M; Villarreal-Garza, C; Gómez, H; Barrios, C H

    2017-08-01

    To evaluate whether a country's Human Development Index (HDI) can help explain the differences in the country's breast cancer and gynecological cancer incidence and mortality rates in the Pan-American region. Ecological analysis. Pan-American region countries with publicly available data both in GLOBOCAN 2012 and the United Nations Development Report 2012 were included (n = 28). Incidence and mortality rates age-standardized per 100,000 were natural log-transformed for breast cancer, ovarian cancer, corpus uteri cancer, and cervical cancer. The mortality-to-incidence ratio (MIR) was calculated for each site. Pearson's correlation test and a simple linear regression were performed. The HDI showed a positive correlation with breast cancer and ovarian cancer incidence and mortality rates, respectively, and a negative correlation with cervical cancer incidence and mortality rates. The HDI and corpus uteri cancer showed no association. MIR and the HDI showed a negative correlation for all tumor types except ovarian cancer. An increment in 1 HDI unit leads to changes in cancer rates: in breast cancer incidence β = 4.03 (95% confidence interval [CI] 2.61; 5.45) P < 0.001, breast cancer mortality β = 1.76 (95% CI 0.32; 3.21) P = 0.019, and breast cancer-MIR β = -0.705 (95% CI 0.704; 0.706) P < 0.001; in cervical cancer incidence β = -3.28 (95% CI -4.78; -1.78) P < 0.001, cervical cancer mortality β = -4.63 (95% CI -6.10; -3.17) P < 0.001, and cervical cancer-MIR β = -1.35 (95% CI -1.83; -0.87) P < 0.001; in ovarian cancer incidence β = 3.26 (95% CI 1.78; 4.75) P < 0.001, ovarian cancer mortality β = 1.82 (95% CI 0.44; 3.20) P = 0.012, and ovarian cancer-MIR β = 5.10 (95% CI 3.22; 6.97) P < 0.001; in corpus uteri cancer incidence β = 2.37 (95% CI -0.33; 5.06) P = 0.83, corpus uteri cancer mortality β = 0.68 (95% CI -2.68; 2.82) P = 0.96, and corpus uteri cancer-MIR β = -2.30 (95% CI -3.19; -1.40) P < 0.001. A

  12. Implementing and evaluating a regional strategy to improve testing rates in VA patients at risk for HIV, utilizing the QUERI process as a guiding framework: QUERI Series

    Directory of Open Access Journals (Sweden)

    Osborn Teresa

    2008-03-01

    Full Text Available Abstract Background We describe how we used the framework of the U.S. Department of Veterans Affairs (VA Quality Enhancement Research Initiative (QUERI to develop a program to improve rates of diagnostic testing for the Human Immunodeficiency Virus (HIV. This venture was prompted by the observation by the CDC that 25% of HIV-infected patients do not know their diagnosis – a point of substantial importance to the VA, which is the largest provider of HIV care in the United States. Methods Following the QUERI steps (or process, we evaluated: 1 whether undiagnosed HIV infection is a high-risk, high-volume clinical issue within the VA, 2 whether there are evidence-based recommendations for HIV testing, 3 whether there are gaps in the performance of VA HIV testing, and 4 the barriers and facilitators to improving current practice in the VA. Based on our findings, we developed and initiated a QUERI step 4/phase 1 pilot project using the precepts of the Chronic Care Model. Our improvement strategy relies upon electronic clinical reminders to provide decision support; audit/feedback as a clinical information system, and appropriate changes in delivery system design. These activities are complemented by academic detailing and social marketing interventions to achieve provider activation. Results Our preliminary formative evaluation indicates the need to ensure leadership and team buy-in, address facility-specific barriers, refine the reminder, and address factors that contribute to inter-clinic variances in HIV testing rates. Preliminary unadjusted data from the first seven months of our program show 3–5 fold increases in the proportion of at-risk patients who are offered HIV testing at the VA sites (stations where the pilot project has been undertaken; no change was seen at control stations. Discussion This project demonstrates the early success of the application of the QUERI process to the development of a program to improve HIV testing rates

  13. Recent seismicity of Italy: Active tectonics of the central Mediterranean region and seismicity rate changes after the Mw 6.3 L'Aquila earthquake

    Science.gov (United States)

    Chiarabba, Claudio; De Gori, Pasquale; Mele, Francesco Mariano

    2015-01-01

    In this paper we present a new image of the instrumental seismicity of Italy, obtained by refining hypocentral determinations for about 100,000 earthquakes that occurred in the period 2005-2012. The improved locations yield new constraints on active tectonics of the central Mediterranean area, where prolonged interaction between nested plates and continental slivers led to the development of the Alpine and Apennines systems. Intermediate-depth and deep earthquakes define a lateral heterogeneous process of delamination and sinking of the continental lithosphere active beneath the mountain belts. Shallow seismicity prevalently occurs beneath elevated topography and correlates with low velocity mantle anomalies, suggesting a superposition of gravity-related forces to the Eurasia-Africa plate convergence. The delamination process drives a paired system of compression and extension that stretches the mountain range while shortening the external side of the belts. The updated seismic catalog permits us to resolve a sharp variation of seismic rates that occurred in recent years, timely after the 2009 Mw 6.3 L'Aquila earthquake. The increase of seismic rates is reasonably due to regional-scale perturbation of the stress field induced by fluid flow and pore-pressure variations within the crust, probably related to deep dehydration processes active beneath the mountain belt.

  14. [Effects of nitrogen fertilization rate and planting density on cotton boll biomass and nitrogen accumulation in extremely early maturing cotton region of Northeast China].

    Science.gov (United States)

    Wang, Zi-Sheng; Wu, Xiao-Dong; Gao, Xiang-Bin; Xu, Min; Shen, Dan; Jin, Lu-Lu; Zhou, Zhi-Guo

    2012-02-01

    Taking cotton cultivars Liaomian 19 and NuCoTN 33B as test materials, a field experiment was conducted to study the effects of nitrogen fertilization rate (0, 240 and 480 kg x hm(-2)) and planting density (75000, 97500 and 120000 plants x hm(-2)) on the boll biomass and nitrogen accumulation in the extremely early maturing cotton region of Northeast China. With the growth and development of cotton, the biomass and nitrogen accumulation of cotton boll, cotton seed, and cotton fiber varied in 'S' shape. Both nitrogen fertilization rate and planting density had significant effects on the dynamic characteristics of boll biomass and nitrogen accumulation, and on the fiber yield and quality. In treatment 240 kg x hm(-2) and 97500 plants x hm(-2), the biomass of single boll, cotton seed and cotton fiber was the maximum, the starting time and ending time of the rapid accumulation period of the biomass and nitrogen were earlier but the duration of the accumulation was shorter, the rapid accumulation speed of the biomass was the maximum, and the distribution indices of the biomass and nitrogen were the lowest in boll shell but the highest in cotton seed and cotton fiber.

  15. Regional changes in charcoal-burning suicide rates in East/Southeast Asia from 1995 to 2011: a time trend analysis.

    Directory of Open Access Journals (Sweden)

    Shu-Sen Chang

    2014-04-01

    Full Text Available Suicides by carbon monoxide poisoning resulting from burning barbecue charcoal reached epidemic levels in Hong Kong and Taiwan within 5 y of the first reported cases in the early 2000s. The objectives of this analysis were to investigate (i time trends and regional patterns of charcoal-burning suicide throughout East/Southeast Asia during the time period 1995-2011 and (ii whether any rises in use of this method were associated with increases in overall suicide rates. Sex- and age-specific trends over time were also examined to identify the demographic groups showing the greatest increases in charcoal-burning suicide rates across different countries.We used data on suicides by gases other than domestic gas for Hong Kong, Japan, the Republic of Korea, Taiwan, and Singapore in the years 1995/1996-2011. Similar data for Malaysia, the Philippines, and Thailand were also extracted but were incomplete. Graphical and joinpoint regression analyses were used to examine time trends in suicide, and negative binomial regression analysis to study sex- and age-specific patterns. In 1995/1996, charcoal-burning suicides accounted for <1% of all suicides in all study countries, except in Japan (5%, but they increased to account for 13%, 24%, 10%, 7%, and 5% of all suicides in Hong Kong, Taiwan, Japan, the Republic of Korea, and Singapore, respectively, in 2011. Rises were first seen in Hong Kong after 1998 (95% CI 1997-1999, followed by Singapore in 1999 (95% CI 1998-2001, Taiwan in 2000 (95% CI 1999-2001, Japan in 2002 (95% CI 1999-2003, and the Republic of Korea in 2007 (95% CI 2006-2008. No marked increases were seen in Malaysia, the Philippines, or Thailand. There was some evidence that charcoal-burning suicides were associated with an increase in overall suicide rates in Hong Kong, Taiwan, and Japan (for females, but not in Japan (for males, the Republic of Korea, and Singapore. Rates of change in charcoal-burning suicide rate did not differ by sex/age group

  16. Community-Based Control of the Brown Dog Tick in a Region with High Rates of Rocky Mountain Spotted Fever, 2012–2013

    Science.gov (United States)

    Drexler, Naomi; Miller, Mark; Gerding, Justin; Todd, Suzanne; Adams, Laura; Dahlgren, F. Scott; Bryant, Nelva; Weis, Erica; Herrick, Kristen; Francies, Jessica; Komatsu, Kenneth; Piontkowski, Stephen; Velascosoltero, Jose; Shelhamer, Timothy; Hamilton, Brian; Eribes, Carmen; Brock, Anita; Sneezy, Patsy; Goseyun, Cye; Bendle, Harty; Hovet, Regina; Williams, Velda; Massung, Robert; McQuiston, Jennifer H.

    2014-01-01

    Rocky Mountain spotted fever (RMSF) transmitted by the brown dog tick (Rhipicephalus sanguineus sensu lato) has emerged as a significant public health risk on American Indian reservations in eastern Arizona. During 2003–2012, more than 250 RMSF cases and 19 deaths were documented among Arizona's American Indian population. The high case fatality rate makes community-level interventions aimed at rapid and sustained reduction of ticks urgent. Beginning in 2012, a two year pilot integrated tick prevention campaign called the RMSF Rodeo was launched in a ∼600-home tribal community with high rates of RMSF. During year one, long-acting tick collars were placed on all dogs in the community, environmental acaricides were applied to yards monthly, and animal care practices such as spay and neuter and proper tethering procedures were encouraged. Tick levels, indicated by visible inspection of dogs, tick traps and homeowner reports were used to monitor tick presence and evaluate the efficacy of interventions throughout the project. By the end of year one, <1% of dogs in the RMSF Rodeo community had visible tick infestations five months after the project was started, compared to 64% of dogs in Non-Rodeo communities, and environmental tick levels were reduced below detectable levels. The second year of the project focused on use of the long-acting collar alone and achieved sustained tick control with fewer than 3% of dogs in the RMSF Rodeo community with visible tick infestations by the end of the second year. Homeowner reports of tick activity in the domestic and peridomestic setting showed similar decreases in tick activity compared to the non-project communities. Expansion of this successful project to other areas with Rhipicephalus-transmitted RMSF has the potential to reduce brown dog tick infestations and save human lives. PMID:25479289

  17. Community-based control of the brown dog tick in a region with high rates of Rocky Mountain spotted fever, 2012-2013.

    Science.gov (United States)

    Drexler, Naomi; Miller, Mark; Gerding, Justin; Todd, Suzanne; Adams, Laura; Dahlgren, F Scott; Bryant, Nelva; Weis, Erica; Herrick, Kristen; Francies, Jessica; Komatsu, Kenneth; Piontkowski, Stephen; Velascosoltero, Jose; Shelhamer, Timothy; Hamilton, Brian; Eribes, Carmen; Brock, Anita; Sneezy, Patsy; Goseyun, Cye; Bendle, Harty; Hovet, Regina; Williams, Velda; Massung, Robert; McQuiston, Jennifer H

    2014-01-01

    Rocky Mountain spotted fever (RMSF) transmitted by the brown dog tick (Rhipicephalus sanguineus sensu lato) has emerged as a significant public health risk on American Indian reservations in eastern Arizona. During 2003-2012, more than 250 RMSF cases and 19 deaths were documented among Arizona's American Indian population. The high case fatality rate makes community-level interventions aimed at rapid and sustained reduction of ticks urgent. Beginning in 2012, a two year pilot integrated tick prevention campaign called the RMSF Rodeo was launched in a ∼ 600-home tribal community with high rates of RMSF. During year one, long-acting tick collars were placed on all dogs in the community, environmental acaricides were applied to yards monthly, and animal care practices such as spay and neuter and proper tethering procedures were encouraged. Tick levels, indicated by visible inspection of dogs, tick traps and homeowner reports were used to monitor tick presence and evaluate the efficacy of interventions throughout the project. By the end of year one, <1% of dogs in the RMSF Rodeo community had visible tick infestations five months after the project was started, compared to 64% of dogs in Non-Rodeo communities, and environmental tick levels were reduced below detectable levels. The second year of the project focused on use of the long-acting collar alone and achieved sustained tick control with fewer than 3% of dogs in the RMSF Rodeo community with visible tick infestations by the end of the second year. Homeowner reports of tick activity in the domestic and peridomestic setting showed similar decreases in tick activity compared to the non-project communities. Expansion of this successful project to other areas with Rhipicephalus-transmitted RMSF has the potential to reduce brown dog tick infestations and save human lives.

  18. Community-based control of the brown dog tick in a region with high rates of Rocky Mountain spotted fever, 2012-2013.

    Directory of Open Access Journals (Sweden)

    Naomi Drexler

    Full Text Available Rocky Mountain spotted fever (RMSF transmitted by the brown dog tick (Rhipicephalus sanguineus sensu lato has emerged as a significant public health risk on American Indian reservations in eastern Arizona. During 2003-2012, more than 250 RMSF cases and 19 deaths were documented among Arizona's American Indian population. The high case fatality rate makes community-level interventions aimed at rapid and sustained reduction of ticks urgent. Beginning in 2012, a two year pilot integrated tick prevention campaign called the RMSF Rodeo was launched in a ∼ 600-home tribal community with high rates of RMSF. During year one, long-acting tick collars were placed on all dogs in the community, environmental acaricides were applied to yards monthly, and animal care practices such as spay and neuter and proper tethering procedures were encouraged. Tick levels, indicated by visible inspection of dogs, tick traps and homeowner reports were used to monitor tick presence and evaluate the efficacy of interventions throughout the project. By the end of year one, <1% of dogs in the RMSF Rodeo community had visible tick infestations five months after the project was started, compared to 64% of dogs in Non-Rodeo communities, and environmental tick levels were reduced below detectable levels. The second year of the project focused on use of the long-acting collar alone and achieved sustained tick control with fewer than 3% of dogs in the RMSF Rodeo community with visible tick infestations by the end of the second year. Homeowner reports of tick activity in the domestic and peridomestic setting showed similar decreases in tick activity compared to the non-project communities. Expansion of this successful project to other areas with Rhipicephalus-transmitted RMSF has the potential to reduce brown dog tick infestations and save human lives.

  19. GIS-mapping of environmental assessment of the territories in the region of intense activity for the oil and gas complex for achievement the goals of the Sustainable Development (on the example of Russia)

    Science.gov (United States)

    Yermolaev, Oleg

    2014-05-01

    - atmosphere, hydrosphere, lithosphere, biosphere, etc. In this way, all thematic groups brought together into four main sections: • The introduction (the maps of a general condition and social-economical state, a region's rating in Republic; • The components of natural, social-economics systems that form the conditions for the ecological situations; • The integrated maps of exertion and change of the environment; • The strategy to reach an ecological equilibrium. The following data confirm that: more than 200 electronic analytical, complex and synthetic maps; more than 1000 small rivers basins, 6000 landscapes areas, 500 anthropogenic pollutions source, etc. The extensive information, richness and diversity of the maps content, objective indices used in the maps, open the door to wide opportunities to apply different methods of cartography analysis comprising both usual visional one and the geographical constructions, cartometry statistical data treatment, respectively. The methods of mathematical-mapping and computer modeling presume to compute spatial correlations and mutual conformity of phenomena and to estimate the homogeneity of the ecological conditions, to reveal the leading factors of distribution and phenomena and processes development using the means of multidimensional statistical analysis.

  20. Leader as achiever.

    Science.gov (United States)

    Dienemann, Jacqueline

    2002-01-01

    This article examines one outcome of leadership: productive achievement. Without achievement one is judged to not truly be a leader. Thus, the ideal leader must be a visionary, a critical thinker, an expert, a communicator, a mentor, and an achiever of organizational goals. This article explores the organizational context that supports achievement, measures of quality nursing care, fiscal accountability, leadership development, rewards and punishments, and the educational content and teaching strategies to prepare graduates to be achievers.

  1. Crustal deformation rates in Assam Valley, Shillong Plateau, Eastern Himalaya, and Indo-Burmese region from 11 years (2002-2013) of GPS measurements

    Science.gov (United States)

    Barman, Prakash; Jade, Sridevi; Shrungeshwara, T. S.; Kumar, Ashok; Bhattacharyya, Sanjeev; Ray, Jagat Dwipendra; Jagannathan, Saigeetha; Jamir, Wangshi Menla

    2017-09-01

    The present study reports the contemporary deformation of the tectonically complex northeast India using 11 years (2002-2013) of GPS observations. The central Shillong Plateau and few sites north of Plateau located in Assam Valley behave like a rigid block with 7 mm/year India-fixed southward velocity. The Euler pole of rotation of this central Shillong Plateau-Assam Valley (SH-AS) block is estimated to be at -25.1° ± 0.2°N, -97.8° ± 1.8°E with an angular velocity of 0.533° ± 0.10° Myr-1 relative to India-fixed reference frame. Kopili fault located between Shillong Plateau and Mikir massif records a dextral slip of 4.7 ± 1.3 mm/year with a locking depth of 10.2 ± 1.4 km indicating the fragmentation of Assam Valley across the fault. Presently, western edge of Mikir massif appears to be locked to Assam block indicating strain accumulation in this region. First-order elastic dislocation modelling of the GPS velocities estimates a slip rate of 16 mm/year along the Main Himalayan Thrust in Eastern Himalaya which is locked over a width of 130 km from the surface to a depth of 17 km with underthrusting Indian plate. Around 9 mm/year arc-normal convergence is accommodated in Lesser Himalaya just south of Main Central Thrust indicating high strain accumulation. Out of 36 mm/year (SSE) India-Sunda plate motion, about 16 mm/year motion is accommodated in Indo-Burmese Fold and Thrust Belt, both as normal convergence ( 6 mm/year) and active slip ( 7-11 mm/year) in this region.

  2. Palaeoclimate reconstruction in the Levant region from the petrographic and growth rate of a MIS 5 stalagmite from the Kanaan cave, Lebanon

    Science.gov (United States)

    Nehme, Carole; Verheyden, Sophie; Stephen, Noble; Delannoy, Jean-Jacques; Salem, Ghada; Gerard, Jocelyne; Farrant, Andrew

    2015-04-01

    Mount Lebanon consists mainly of carbonate rocks which contain numerous caves with an abundance of well-preserved speleothem deposits. A 23 cm long stalagmite (K1-2010) was obtained from Kanaan cave, situated just north of Beirut within the western flank of central Mount Lebanon at 100 m altitude. To develop an age model for the speleothem, a suite of uranium series (U-Th) dates was performed in the NERC Isotope Geosciences Laboratory at the British Geological Survey. The speleothem displays two main segments: The lower segment (segment 1) is 8.2 cm long and displays a general growth axis varying from 8.5 cm diameter in the lower part to 6 cm in its middle part. This segment grew from at least 129.7 ± 0.8 ka to 111.8 ± 0.7 ka. Several hiatuses are observed and are probably linked to detrital layers. The higher segment (segment 2) is 12.3 cm long and displays a thinner diameter varying from 6.5 to 4 cm at its topmost part. This segment grew continuously from 102.5 ± 0.96 to 85.3 ± 0.8 ka. The lower segment, deposited during S-5 event in the Eastern Mediterranean (128-117 ka) shows growth rates reaching 0.15 cm/100 yr coinciding with enhanced rainfall events in speleothem records from the Southern Levant during the S-5 event as suggested by Frumkin (1999) and Bar-Mathews (2003). Speleothem growth stopped between 103.5 and 109 ka and the growth axis rotated. The higher segment shows a more moderate growth rate (0.09 cm/100 yr) until 100 ka, corresponding to low δ18O values in speleothems from Peqiin and Soreq caves and thus to enhanced rainfall events. Very low growth rates (0.03 to 0.06 cm/100 yr) from 100 to 85 ka are associated with colder climates during the latter part of MIS5 subsequent to the S-5 event. This stalagmite demonstrates the palaeoclimatic potential of speleothem records in the northern Levant region.

  3. Value of systematic intervention for chronic obstructive pulmonary disease in a regional Japanese city based on case detection rate and medical cost

    Directory of Open Access Journals (Sweden)

    Tawara Y

    2015-08-01

    Full Text Available Yuichi Tawara,1 Hideaki Senjyu,1 Kenichiro Tanaka,1 Takako Tanaka,1 Masaharu Asai,1 Ryo Kozu,2 Mitsuru Tabusadani,3 Sumihisa Honda,1 Terumitsu Sawai1 1Department of Cardiopulmonary Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 2Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, Japan; 3Center for Industry, University and Government Cooperation, Nagasaki University, Nagasaki, Japan Objective: We established a COPD taskforce for early detection, diagnosis, treatment, and intervention. We implemented a pilot intervention with a prospective and longitudinal design in a regional city. This study evaluates the usefulness of the COPD taskforce and intervention based on COPD case detection rate and per capita medical costs.Method: We distributed a questionnaire to all 8,878 inhabitants aged 50–89 years, resident in Matsuura, Nagasaki Prefecture in 2006. Potentially COPD-positive persons received a pulmonary function test and diagnosis. We implemented ongoing detection, examination, education, and treatment interventions, performed follow-up examinations or respiratory lessons yearly, and supported the health maintenance of each patient. We compared COPD medical costs in Matsuura and in the rest of Nagasaki Prefecture using data from 2004 to 2013 recorded by the association of Nagasaki National Health Insurance Organization, assessing 10-year means and annual change.Results: As of 2014, 256 people have received a definitive diagnosis of COPD; representing 31% of the estimated total number of COPD patients. Of the cases detected, 87.5% were mild or moderate in severity. COPD medical costs per patient in Matsuura were significantly lower than the rest of Nagasaki Prefecture, as was rate of increase in cost over time.Conclusion: The COPD program in Matsuura enabled early detection and treatment of COPD patients and helped to lower the associated burden of medical costs. The

  4. Addressing Academic Dishonesty among the Highest Achievers

    Science.gov (United States)

    Miller, Angela D.; Murdock, Tamera B.; Grotewiel, Morgan M.

    2017-01-01

    Although research shows that higher-achieving students report engaging in cheating behaviors less frequently than lower-achieving students, the cheating rates among this population are still startling. Certain aspects of the context of being a high-achieving student support academic dishonesty. We investigate integrity among the highest achievers…

  5. Aerodynamic pressure and heating-rate distributions in tile gaps around chine regions with pressure gradients at a Mach number of 6.6

    Science.gov (United States)

    Hunt, L. Roane; Notestine, Kristopher K.

    1990-06-01

    Surface and gap pressures and heating-rate distributions were obtained for simulated Thermal Protection System (TPS) tile arrays on the curved surface test apparatus of the Langley 8-Foot High Temperature Tunnel at Mach 6.6. The results indicated that the chine gap pressures varied inversely with gap width because larger gap widths allowed greater venting from the gap to the lower model side pressures. Lower gap pressures caused greater flow ingress from the surface and increased gap heating. Generally, gap heating was greater in the longitudinal gaps than in the circumferential gaps. Gap heating decreased with increasing gap depth. Circumferential gap heating at the mid-depth was generally less than about 10 percent of the external surface value. Gap heating was most severe at local T-gap junctions and tile-to-tile forward-facing steps that caused the greatest heating from flow impingement. The use of flow stoppers at discrete locations reduced heating from flow impingement. The use of flow stoppers at discrete locations reduced heating in most gaps but increased heating in others. Limited use of flow stoppers or gap filler in longitudinal gaps could reduce gap heating in open circumferential gaps in regions of high surface pressure gradients.

  6. Comparing Science Achievement Constructs: Targeted and Achieved

    Science.gov (United States)

    Ferrara, Steve; Duncan, Teresa

    2011-01-01

    This article illustrates how test specifications based solely on academic content standards, without attention to other cognitive skills and item response demands, can fall short of their targeted constructs. First, the authors inductively describe the science achievement construct represented by a statewide sixth-grade science proficiency test.…

  7. Behavioral patterns, parity rate and natural infection analysis in anopheline species involved in the transmission of malaria in the northeastern Brazilian Amazon region.

    Science.gov (United States)

    Barbosa, Ledayane Mayana Costa; Souto, Raimundo Nonato Picanço; Dos Anjos Ferreira, Ricardo Marcelo; Scarpassa, Vera Margarete

    2016-12-01

    The characterization of behavioral patterns allows a better understanding of the transmission dynamics and the design of more effective malaria vector control strategies. This study analyzed the behavioral patterns of the Anopheles species of the Coração district situated in the northeast of the Brazilian Amazon region. The behavioral patterns of the anopheline species were measured based on the 36 collection sites of this district from December 2010 to November 2011. Collections of four hours for three consecutive nights each month and four 12-h collections, comprising two in the rainy season and two in the dry season, were performed. Furthermore, to infer the anthropophily and zoophily indexes, four additional four-hour collections were performed. The samples were also evaluated for parity rate and natural infectivity for Plasmodium spp. A total of 1689 anophelines were captured, comprising of nine species and two subgenera (Nyssorhynchus - six species, and Anopheles - three species). Anopheles darlingi was the most abundant and widely distributed species in the area, followed by A. braziliensis and A.marajoara. Anopheles darlingi and A. marajoara were the only species present in the four collections of 12-h, but only A. darlingi showed activity throughout night. Anopheles darlingi was the most anthropophilic species (AI=0.40), but the zoophily index was higher (ZI=0.60), revealing an eclectic and opportunistic behavior. Of the six most frequent species, A. nuneztovari s.l. was the most zoophilic species (ZI=1.00). All captured species showed predominance towards biting in outdoor environments. Anopheles darlingi and A. braziliensis showed multimodal biting peaks, whereas A. marajoara revealed a stable pattern, with the biting peak after sunset. Using the PCR technique, no anopheline was found infected with the malaria parasite. Since A. darlingi and A. marajoara are recognized as important vectors in this region, the district of Coração may be considered as

  8. Tails assumptions and posterior concentration rates for mixtures of Gaussians

    OpenAIRE

    Naulet, Zacharie; Rousseau, Judith

    2016-01-01

    Nowadays in density estimation, posterior rates of convergence for location and location-scale mixtures of Gaussians are only known under light-tail assumptions; with better rates achieved by location mixtures. It is conjectured, but not proved, that the situation should be reversed under heavy tails assumptions. The conjecture is based on the feeling that there is no need to achieve a good order of approximation in regions with few data (say, in the tails), favoring location-scale mixtures w...

  9. Achievement report for fiscal 1998 on research and development project for regional consortiums. Regional consortium field (Development of super devices for medical treatment devices using three-dimensional micro processing technology (the second year)); 1998 nendo chiiki consortium bun'ya. Maikuro sanjigen kako gijutsu ni yoru iryo kikiyo super device no kaihatsu (dai 2 nendo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    It is intended to develop super devices for medical treatment devices using a three-dimensional micro processing technology by developing and combining precision processing technologies accumulated in the Suwa area. Main targets were placed on device size reduction, and a high reliability portable chemical liquid sustaining injector. This paper describes achievements made in fiscal 1998. Micromotors currently used have as low output torque as 1/4 of the target. Enhancement of reduction gear mechanism efficiency and durability is the problem to be solved. Microtubes with an inner diameter of 0.1 mm were produced on a trial basis by using four kinds of materials. The delivery mechanism assured the targeted flow rate successfully by using the direct cum screw system, but reduction in driving torque is desired. Completion of the cartridge system is also in the realm of aim. Joints will be moved closer to commercialization by selecting materials taking into account the chemical resistance and disposition. Micro connectors and cables still have problems for development. The bubble sensor was virtually decided to be of optical type from the points of detection performance requirements. Detectors and peripheral devices will be reduced in dimensions, and their reliability will be enhanced. The flow rate sensor has a problem to be solved in responsiveness to intermittent flows. (NEDO)

  10. PanDAR: a wide-area, frame-rate, and full color lidar with foveated region using backfilling interpolation upsampling

    Science.gov (United States)

    Mundhenk, T. Nathan; Kim, Kyungnam; Owechko, Yuri

    2015-01-01

    LIDAR devices for on-vehicle use need a wide field of view and good fidelity. For instance, a LIDAR for avoidance of landing collisions by a helicopter needs to see a wide field of view and show reasonable details of the area. The same is true for an online LIDAR scanning device placed on an automobile. In this paper, we describe a LIDAR system with full color and enhanced resolution that has an effective vertical scanning range of 60 degrees with a central 20 degree fovea. The extended range with fovea is achieved by using two standard Velodyne 32-HDL LIDARs placed head to head and counter rotating. The HDL LIDARS each scan 40 degrees vertical and a full 360 degrees horizontal with an outdoor effective range of 100 meters. By positioning them head to head, they overlap by 20 degrees. This creates a double density fovea. The LIDAR returns from the two Velodyne sensors do not natively contain color. In order to add color, a Point Grey LadyBug panoramic camera is used to gather color data of the scene. In the first stage of our system, the two LIDAR point clouds and the LadyBug video are fused in real time at a frame rate of 10 Hz. A second stage is used to intelligently interpolate the point cloud and increase its resolution by approximately four times while maintaining accuracy with respect to the 3D scene. By using GPGPU programming, we can compute this at 10 Hz. Our backfilling interpolation methods works by first computing local linear approximations from the perspective of the LIDAR depth map. The color features from the image are used to select point cloud support points that are the best points in a local group for building the local linear approximations. This makes the colored point cloud more detailed while maintaining fidelity to the 3D scene. Our system also makes objects appearing in the PanDAR display easier to recognize for a human operator.

  11. Report of the Regional Meeting for Latin America and the Caribbean in Preparation for the World Conference to Review and Appraise the Achievements of the United Nations Decade for Women: Equality, Development, and Peace (Havana, Cuba, November 19-23, 1984).

    Science.gov (United States)

    United Nations Economic and Social Council, New York, NY.

    The minutes of the regional meeting (for Latin America and the Caribbean) summarize discussions pertaining to the critical review and appraisal of the progress achieved and the formulation of strategies for the advancement of women up to the year 2000. They suggest concrete measures for overcoming obstacles to the realization of the goals and…

  12. Report of the Regional Meeting for Latin America and the Caribbean in Preparation for the World Conference to Review and Appraise the Achievements of the United Nations Decade for Women: Equality, Development, and Peace (Havana, Cuba, November 19-23, 1984).

    Science.gov (United States)

    United Nations Economic and Social Council, New York, NY.

    The minutes of the regional meeting (for Latin America and the Caribbean) summarize discussions pertaining to the critical review and appraisal of the progress achieved and the formulation of strategies for the advancement of women up to the year 2000. They suggest concrete measures for overcoming obstacles to the realization of the goals and…

  13. Regionalism, Regionalization and Regional Development

    Directory of Open Access Journals (Sweden)

    Liviu C. Andrei

    2016-03-01

    Full Text Available Sustained development is a concept associating other concepts, in its turn, in the EU practice, e.g. regionalism, regionalizing and afferent policies, here including structural policies. This below text, dedicated to integration concepts, will limit on the other hand to regionalizing, otherwise an aspect typical to Europe and to the EU. On the other hand, two aspects come up to strengthen this field of ideas, i.e. the region (al-regionalism-(regional development triplet has either its own history or precise individual outline of terms.

  14. An Ecological Study of Community-Level Correlates of Suicide Mortality Rates in the Flemish Region of Belgium, 1996-2005

    Science.gov (United States)

    Hooghe, Marc; Vanhoutte, Bram

    2011-01-01

    An ecological study of age-standardized suicide rates in Belgian communities (1996-2005) was conducted using spatial regression techniques. Community characteristics were significantly related to suicide rates. There was mixed support for the social integration perspective: single person households were associated with higher suicide rates, while…

  15. Soil-restoration rate and initial soil formation trends on example of anthropogenically affected soils of opencast mine in Kursk region, Russian Federation

    Science.gov (United States)

    Pigareva, Tatiana

    2015-04-01

    The mining industry is one of the main factors which anthropogenically change the environment. Mining process results in removing of the rocks and mechanical changes of considerable amounts of ground. One of the main results of mining arising of antropic ecosystems as well as increasing of the new created soils total area is technosols. The main factor controlling the soil formation in postmining environment is the quality of spoiled materials. Initial soil formation has been investigated on spoils of the largest iron ore extraction complex in Russia - Mikhailovsky mining and concentration complex which is situated in Kursk region, Russia. Investigated soils are presented by monogenetic weak developed soils of different age (10-15-20 years). Young soils are formed on the loess parent materials (20 year-old soil), or on a mix of sand and clay overburdens (15 and 10-year-old soils). Anthropogenically affected soils are characterized by well-developed humus horizon which is gradually replaced by weakly changed soil-building rocks (profile type A-C for 10-, 15-years old soils, and A-AC-C for 20 years old soils). Gray-humus soils are characterized by presence of diagnostic humus horizon gradually replaced by soil-building rock. The maximum intensity of humus accumulation has been determined in a semi-hydromorphic 10-year-old soil developed on the mixed heaps which is connected with features of water-air conditions complicating mineralization of plant remnants. 20-year-old soil on loess is characterized by rather high rate of organic substances accumulation between all the automorphous soils. It was shown that one of the most effective restoration ways for anthropogenically affected soils is a biological reclamation. Since overburdens once appeared on a day surface are overgrown badly in the first years, they are subject to influence of water and wind erosion. Our researchers have found out that permanent grasses are able to grow quickly; they accumulate a considerable

  16. REGIONALLY HETEROGENEOUS OF INTEREST RATE,TRANS-REGIONAL IMPACT OF INCOME AND HOUSING PRICE SPILLOVERS%利率效果区域异质性、收入跨区影响与房价溢出效应∗

    Institute of Scientific and Technical Information of China (English)

    余华义; 黄燕芬

    2015-01-01

    本文首先构建了理论分析框架,解释了中国不同城市间房价溢出效应、收入对房价的跨区影响,以及利率调整对不同城市房价的区域异质性影响。本文利用 GVAR 模型对该框架进行了实证,结果显示北京等一线城市的房价波动对其他城市具有较大的溢出性,而中西部城市的房价溢出性则不明显。一线城市和东部城市的房价波动不仅受本城市人均收入变动的影响,还在很大程度上受其他城市收入变动的影响,而中西部城市的房价则主要受本城市收入变动的影响。利率变动对一线城市和东部城市的房价影响则较大,而对中西部城市的房价影响有限。本文结论具有明确的政策含义,比如政府应通过稳定一线城市房价以达到稳定全国房价的目的,促进公共产品均等化,实行地区差异化的房地产政策等。通过利率调整来调控房价也是一个可行的政策选项。%Firstly,this paper constructs a theoretical framework which can explain the spillovers of housing price,the trans-regional impact of real income per capita on housing prices as well as the impact of interest rate shock to the housing price development among different cities.Then,using GVAR model, the empirical results show that,the first-tier cities,such as Beij ing,have comparatively large spillovers of housing price,while the spillovers in central and western cities are not obvious.The housing price of first-tier and eastern cities are not only affected by the real income per capita of these cities themselves but also affected by that of other cities to a large extent,while the housing price of central and western cities are mainly affected by the real income per capita of these cities themselves.The real interest rate changes have large influence on the housing price of first-tier cities and eastern cities,but weak influence on that of cen-tral and western cities.The empirical results

  17. 'No delays achiever'.

    Science.gov (United States)

    2007-05-01

    The latest version of the NHS Institute for Innovation and Improvement's 'no delays achiever', a web based tool created to help NHS organisations achieve the 18-week target for GP referrals to first treatment, is available at www.nodelaysachiever.nhs.uk.

  18. Inflation Differentials across Regions in Turkey

    Directory of Open Access Journals (Sweden)

    Duran Hasan Engin

    2016-04-01

    Full Text Available The aim of the present article is to analyze the convergence of regional inflation rates in Turkey from 2004 to 2015 by adopting sigma convergence and distribution dynamics approaches. The outcomes of our research can be summarized in two groups. First, inflation disparities tend to decline over time, especially during the post-crisis period after 2010. Hence, the aggregate price stabilization and disinflation process in Turkey is coupled with convergence in inflation rates across regions. Second, in addition to the findings in the literature, we find that regions change their relative inflation rate positions quite often. This indicates that regional inflation behavior is random and non-structural, as the relatively high and low inflationary places tend to change their quintiles frequently. The results imply several policy suggestions. First, achieving inflation convergence is a harder task than initially understood, as it seems to show random behavior. Second, trade integration can be an option to foster regional price convergence.

  19. Current status of cholesterol goal attainment after statin therapy among patients with hypercholesterolemia in Asian countries and region: the Return on Expenditure Achieved for Lipid Therapy in Asia (REALITY-Asia) study.

    Science.gov (United States)

    Kim, Hyo-Soo; Wu, Yangfeng; Lin, Shing-Jong; Deerochanawong, Chaicharn; Zambahari, Robaayah; Zhao, Liancheng; Zhang, Qiaoyi; Yan, Peter

    2008-07-01

    Data on achieving National Cholesterol Education Program Adult Treatment Panel III (ATP III) goals in Asia are limited. To examine treatment patterns, goal attainment, and factors influencing treatment among patients in 6 Asian countries who were taking statins. A retrospective cohort study was conducted in China, Korea, Malaysia, Singapore, Taiwan, and Thailand, where 437 physicians (41% cardiologists) recruited adults with hypercholesterolemia newly initiated on statin monotherapy. Of 2622 patients meeting inclusion and exclusion criteria, approximately 66% had coronary heart disease (CHD)/diabetes mellitus, 24% had no CHD but > or =2 risk factors, and 10% had no CHD and or =2 risk factors (goal: <130 mg/dL), and 81% of those without CHD and <2 risk factors (goal: <160 mg/dL). Most patients who achieved goals did so within the first 3 months. Increasing age (odds ratio (OR)=1.015 per 1-year increment; 95% confidence interval (CI)=1.005-1.206; p=0.0038) and initial statin potency (OR=2.253; 95% CI=1.364-3.722; p=0.0015) were directly associated with goal attainment, whereas increased cardiovascular risk (OR=0.085; 95% CI=0.053-0.134; p<0.0001 for CHD/diabetes mellitus at baseline compared with <2 risk factors,) and baseline LDL-C (OR=0.990; 95% CI=0.987-0.993); p<0.0001 per 1-mg/dL increment) were inversely associated with LDL-C goal achievement. Limitations of this study include potential differences in treatment settings and cardiovascular risk factors between different countries and centers. In addition, the effects on cholesterol goal achievement of concomitant changes in lifestyle were not assessed. LDL-C goal attainment is low in Asians, particularly those with CHD/diabetes. More effective patient monitoring, treatments, including combining regimens and dose titration, and adherence to these treatments along with therapeutic lifestyle counseling may facilitate goal attainment.

  20. Progreso en el logro de los Objetivos de Desarrollo del Milenio: la mortalidad por cáncer de cérvix desciende en Colombia / Progress in the achievement of the millennium development goals: the rate of mortality by cervical cancer decreases in Colombia

    Directory of Open Access Journals (Sweden)

    Jancy A. Huertas Q.

    2015-09-01

    Full Text Available Resumen Colombia cumpliendo en 2015 la fecha establecida para el alcance de los Objetivos de Desarrollo del Milenio (odm, ha logrado un descenso progresivo en las tasas de incidencia y mortalidad por cáncer de cuello uterino durante el decenio 2000 - 2010. En este período, la tasa de mortalidad descendió significativamente para las mujeres de todas las edades (11,4% en 1998 – 6,9 en 2011, meta a 2015: 6,8% y aumentó la proporción de casos in situ detectados oportunamente (63,31% en 2012. Colombia asumió el cáncer como un problema de salud pública y logró posicionarlo en la agenda pública. De igual forma, el cambio en el conocimiento y el autocuidado de la población, dieron como resultado un aumento en el pronóstico de las pacientes. A pesar de estos avances, el país continúa concentrando esfuerzos en reducir tasas de incidencia y mortalidad, aumentar los niveles de tecnología y promover mayor desarrollo en las regiones, mejorar sustancialmente el derecho de las mujeres a ser protegidas contra esta enfermedad, a través de acceso sin barreras a los programas de tamización y tratamientos del cáncer de cuello uterino. Y finalmente, la inclusión más amplia de la vacuna contra el vph con intervalo de cada 5 años, y que tiene un mayor potencial, especialmente entre las mujeres más jóvenes. La pregunta clave hoy en día es cómo acelerar ese ritmo de progreso en los indicadores propuestos por la agenda para el desarrollo después del 2015: Objetivos de Desarrollo Sostenible (ods, y ofrecer suficientes ejemplos de estrategias eficaces y adecuadas, y proporcionar experiencias en un contexto latinoamericano./ Abstract Two years before the deadline set for the achievement of the Millennium Development Goals (MDG, Colombia is experiencing a steady decline in the incidence and mortality rates of cervical cancer during the 2000-2010 decade. During this time, the mortality rate decreased significantly for women of all ages (11,4% in

  1. Quantification of human epidermal growth factor receptor 2 immunohistochemistry using the Ventana Image Analysis System: correlation with gene amplification by fluorescence in situ hybridization: the importance of instrument validation for achieving high (>95%) concordance rate.

    Science.gov (United States)

    Dennis, Jake; Parsa, Rezvaneh; Chau, Donnie; Koduru, Prasad; Peng, Yan; Fang, Yisheng; Sarode, Venetia Rumnong

    2015-05-01

    The use of computer-based image analysis for scoring human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) has gained a lot of interest recently. We investigated the performance of the Ventana Image Analysis System (VIAS) in HER2 quantification by IHC and its correlation with fluorescence in situ hybridization (FISH). We specifically compared the 3+ IHC results using the manufacturer's machine score cutoffs versus laboratory-defined cutoffs with the FISH assay. Using the manufacturer's 3+ cutoff (VIAS score; 2.51 to 3.5), 181/536 (33.7%) were scored 3+, and FISH was positive in 147/181 (81.2%), 2 (1.1%) were equivocal, and 32 (17.6%) were FISH (-). Using the laboratory-defined 3+ cutoff (VIAS score 3.5), 52 (28.7%) cases were downgraded to 2+, of which 29 (55.7%) were FISH (-), and 23 (44.2%) were FISH (+). With the revised cutoff, there were improvements in the concordance rate from 89.1% to 97.0% and in the positive predictive value from 82.1% to 97.6%. The false-positive rate for 3+ decreased from 9.0% to 0.8%. Six of 175 (3.4%) IHC (-) cases were FISH (+). Three cases with a VIAS score 3.5 showed polysomy of chromosome 17. In conclusion, the VIAS may be a valuable tool for assisting pathologists in HER2 scoring; however, the positive cutoff defined by the manufacturer is associated with a high false-positive rate. This study highlights the importance of instrument validation/calibration to reduce false-positive results.

  2. [Achievement of therapeutic objectives].

    Science.gov (United States)

    Mantilla, Teresa

    2014-07-01

    Therapeutic objectives for patients with atherogenic dyslipidemia are achieved by improving patient compliance and adherence. Clinical practice guidelines address the importance of treatment compliance for achieving objectives. The combination of a fixed dose of pravastatin and fenofibrate increases the adherence by simplifying the drug regimen and reducing the number of daily doses. The good tolerance, the cost of the combination and the possibility of adjusting the administration to the patient's lifestyle helps achieve the objectives for these patients with high cardiovascular risk. Copyright © 2014 Sociedad Española de Arteriosclerosis y Elsevier España, S.L. All rights reserved.

  3. Adoptees' Educational Achievements

    DEFF Research Database (Denmark)

    Olsen, Rikke Fuglsang

    to country of origin. The results suggest that the relatively small gap between non-kin adoptees’ and non-adoptees’ educational achievements widens between ages 20 and 25. Moreover, the results show some differences in educational outcomes among non-kin adoptees with different countries of origin.......This study analyses educational achievement at age 20 for 3,180 non-kin adoptees and at age 25 for 1,559 non-kin adoptees in Denmark by comparing them to non-adoptees. The study also analyses whether there are within-group differences in the educational achievement of non-kin adoptees according...

  4. A Study of Achievements of the Stock Market in China′ s West Regions and Certain Proposals For the Market′ s Development%西部股票市场绩效研究与发展建议

    Institute of Scientific and Technical Information of China (English)

    刘群

    2001-01-01

    Proceeding from a study of the role of the stock market in and its impact on the development of the economy in the West Regions, the present paper maintains that the improvement of operation efficiency in the stock market of the West Regions contributes a lot to the increase of investment in the regions. The result of the study indicates that to solve the problem of fund shortage, it is necessary to quicken the process of economic monetization and devote major efforts to foster the stock market in the regions.%研究西部股票市场对西部经济发展的作用与影响,认为提高西部股票市场的运作效率,有助于促进西部投资的增长。研究结果表明,要解决西部资金短缺状况,必须加快西部经济货币化进程,大力培育西部股票市场。

  5. Measurement of regional rates of cerebral protein synthesis with L-[1-11C]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys.

    NARCIS (Netherlands)

    Smith, C.B.; Schmidt, K.C.; Qin, M.; Burlin, T.V.; Cook, M.P.; Kang, J.; Saunders, R.C.; Bacher, J.D.; Carson, R.E.; Channing, M.A.; Eckelman, W.C.; Herscovitch, P.; Laverman, P.; Vuong, B.K.

    2005-01-01

    The confounding effect of recycling of amino acids derived from tissue protein breakdown into the precursor pool for protein synthesis has been an obstacle to adapting in vivo methods for determination of regional rates of cerebral protein synthesis (rCPS) to positron emission tomography (PET). We

  6. Flood Insurance Rate Maps and Base Flood Elevations, FIRM, DFIRM, BFE, Chattahoochee-Flint Regional Data Q3 Flood Data, Published in 2006, 1:12000 (1in=1000ft) scale, Chattahoochee-Flint Regional Development.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Flood Insurance Rate Maps and Base Flood Elevations, FIRM, DFIRM, BFE dataset, published at 1:12000 (1in=1000ft) scale, was produced all or in part from LIDAR...

  7. Offshore baseline for the exposed East Beaufort Sea, Alaska coastal region (U.S. Canadian Border to the Hulahula River) generated to calculate shoreline change rates

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes a reference baseline used by the Digital Shoreline Analysis System (DSAS) to calculate rate-of-change statistics for the exposed north coast of...

  8. Offshore baseline for the sheltered East Beaufort Sea, Alaska coastal region (U.S. Canadian Border to the Hulahula River) generated to calculate shoreline change rates

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes a reference baseline used by the Digital Shoreline Analysis System (DSAS) to calculate rate-of-change statistics for the sheltered north coast...

  9. Offshore baseline for the sheltered West Beaufort Sea, Alaska coastal region (Colville River to Point Barrow) generated to calculate shoreline change rates

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes a reference baseline used by the Digital Shoreline Analysis System (DSAS) to calculate rate-of-change statistics for the sheltered north coast...

  10. Offshore baseline for the sheltered Central Beaufort Sea, Alaska coastal region (Hulahula River to the Colville River) generated to calculate shoreline change rates

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes a reference baseline used by the Digital Shoreline Analysis System (DSAS) to calculate rate-of-change statistics for the sheltered north coast...

  11. Offshore baseline for the exposed West Beaufort Sea, Alaska coastal region (Colville River to Point Barrow) generated to calculate shoreline change rates

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes a reference baseline used by the Digital Shoreline Analysis System (DSAS) to calculate rate-of-change statistics for the exposed north coast of...

  12. Offshore baseline for the exposed Central Beaufort Sea, Alaska coastal region (Hulahula River to the Colville River) generated to calculate shoreline change rates

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes a reference baseline used by the Digital Shoreline Analysis System (DSAS) to calculate rate-of-change statistics for the exposed north coast of...

  13. Exemplar pediatric collaborative improvement networks: achieving results.

    Science.gov (United States)

    Billett, Amy L; Colletti, Richard B; Mandel, Keith E; Miller, Marlene; Muething, Stephen E; Sharek, Paul J; Lannon, Carole M

    2013-06-01

    A number of pediatric collaborative improvement networks have demonstrated improved care and outcomes for children. Regionally, Cincinnati Children's Hospital Medical Center Physician Hospital Organization has sustained key asthma processes, substantially increased the percentage of their asthma population receiving "perfect care," and implemented an innovative pay-for-performance program with a large commercial payor based on asthma performance measures. The California Perinatal Quality Care Collaborative uses its outcomes database to improve care for infants in California NICUs. It has achieved reductions in central line-associated blood stream infections (CLABSI), increased breast-milk feeding rates at hospital discharge, and is now working to improve delivery room management. Solutions for Patient Safety (SPS) has achieved significant improvements in adverse drug events and surgical site infections across all 8 Ohio children's hospitals, with 7700 fewer children harmed and >$11.8 million in avoided costs. SPS is now expanding nationally, aiming to eliminate all events of serious harm at children's hospitals. National collaborative networks include ImproveCareNow, which aims to improve care and outcomes for children with inflammatory bowel disease. Reliable adherence to Model Care Guidelines has produced improved remission rates without using new medications and a significant increase in the proportion of Crohn disease patients not taking prednisone. Data-driven collaboratives of the Children's Hospital Association Quality Transformation Network initially focused on CLABSI in PICUs. By September 2011, they had prevented an estimated 2964 CLABSI, saving 355 lives and $103,722,423. Subsequent improvement efforts include CLABSI reductions in additional settings and populations.

  14. Machine learning and linear regression models to predict catchment-level base cation weathering rates across the southern Appalachian Mountain region, USA

    Science.gov (United States)

    Nicholas A. Povak; Paul F. Hessburg; Todd C. McDonnell; Keith M. Reynolds; Timothy J. Sullivan; R. Brion Salter; Bernard J. Crosby

    2014-01-01

    Accurate estimates of soil mineral weathering are required for regional critical load (CL) modeling to identify ecosystems at risk of the deleterious effects from acidification. Within a correlative modeling framework, we used modeled catchment-level base cation weathering (BCw) as the response variable to identify key environmental correlates and predict a continuous...

  15. Antarctic ice-mass balance 2003 to 2012: regional reanalysis of GRACE satellite gravimetry measurements with improved estimate of glacial-isostatic adjustment based on GPS uplift rates

    NARCIS (Netherlands)

    Sasgen, I.; Konrad, H.; Ivins, E.R.; van den Broeke, M.R.|info:eu-repo/dai/nl/073765643; Bamber, J.L.; Martinec, Z.; Klemann, V.

    2013-01-01

    We present regional-scale mass balances for 25 drainage basins of the Antarctic Ice Sheet (AIS) from satellite observations of the Gravity and Climate Experiment (GRACE) for time period January 2003 to September 2012. Satellite gravimetry estimates of the AIS mass balance are strongly influenced by

  16. Antarctic ice-mass balance 2003 to 2012: regional reanalysis of GRACE satellite gravimetry measurements with improved estimate of glacial-isostatic adjustment based on GPS uplift rates

    NARCIS (Netherlands)

    Sasgen, I.; Konrad, H.; Ivins, E.R.; van den Broeke, M.R.; Bamber, J.L.; Martinec, Z.; Klemann, V.

    2013-01-01

    We present regional-scale mass balances for 25 drainage basins of the Antarctic Ice Sheet (AIS) from satellite observations of the Gravity and Climate Experiment (GRACE) for time period January 2003 to September 2012. Satellite gravimetry estimates of the AIS mass balance are strongly influenced by

  17. Reported Diabetes Mellitus Prevalence Rates in the Colombia Healthcare System from 2009 to 2012: Analysis by Regions Using Data of the Official Information Sources.

    Science.gov (United States)

    Barengo, Noël C; Tamayo, Diana Carolina

    2015-01-01

    The objective of this study was to describe the reported diabetes mellitus (DM) prevalence rates of the 20-79-year-old population in Colombia from 2009 to 2012 reported by the healthcare system. Information on number of patients treated for DM was obtained by the Integral Information System of Social Protection (SISPRO), the registry of the Ministry of Health and Social Protection, and the High Cost Account (CAC), an organization to trace high expenditure diseases. From both sources age-standardized reported DM prevalence rates per 100.000 inhabitants from 2009 to 2012 were calculated. Whereas the reported DM prevalence rates of SISPRO revealed an increase from 964/100.000 inhabitants (2009) to 1398/100.000 inhabitants in 2012 (mean annual increase 141/100.000; p value: 0.001), the respective rates in the CAC register were 1082/100.000 (2009) and 1593/100.000 in 2012 (mean annual increase 165/100.000; p value: 0.026). The number of provinces reporting not less than 19% of the highest national reported DM prevalence rates (1593/100.000) increased from two in 2009 to ten in 2012. Apparently, the registries and the information retrieving system have been improved during 2009 and 2012, resulting in a greater capacity to identify and report DM cases by the healthcare system.

  18. Reported Diabetes Mellitus Prevalence Rates in the Colombia Healthcare System from 2009 to 2012: Analysis by Regions Using Data of the Official Information Sources

    Science.gov (United States)

    Barengo, Noël C.; Tamayo, Diana Carolina

    2015-01-01

    The objective of this study was to describe the reported diabetes mellitus (DM) prevalence rates of the 20–79-year-old population in Colombia from 2009 to 2012 reported by the healthcare system. Information on number of patients treated for DM was obtained by the Integral Information System of Social Protection (SISPRO), the registry of the Ministry of Health and Social Protection, and the High Cost Account (CAC), an organization to trace high expenditure diseases. From both sources age-standardized reported DM prevalence rates per 100.000 inhabitants from 2009 to 2012 were calculated. Whereas the reported DM prevalence rates of SISPRO revealed an increase from 964/100.000 inhabitants (2009) to 1398/100.000 inhabitants in 2012 (mean annual increase 141/100.000; p value: 0.001), the respective rates in the CAC register were 1082/100.000 (2009) and 1593/100.000 in 2012 (mean annual increase 165/100.000; p value: 0.026). The number of provinces reporting not less than 19% of the highest national reported DM prevalence rates (1593/100.000) increased from two in 2009 to ten in 2012. Apparently, the registries and the information retrieving system have been improved during 2009 and 2012, resulting in a greater capacity to identify and report DM cases by the healthcare system. PMID:26494999

  19. TREND AND VALIDITY OF ANKYLOSING SPONDYLITIS PREVALENCE AND PATIENT MORTALITY RATES IN THE ADULT POPULATION OF THE TULA REGION VERSUS THE RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    V. N. Sorotskaya

    2015-01-01

    Full Text Available Ankylosing spondylitis (AS is a chronic systemic disease of the axial skeleton. Recently, there has been increased interest among practitioners and researchers in AS. Because of difficulties in conducting epidemiological surveys studying statistical data on its prevalence and patient mortality is of great importance. It permit introduction of necessary corrections into organization of medical care to patients on the basis of analysis of the situation in the region.Objective: to study the trend and validity of data on AS prevalence and patient mortality in the adult population of the Tula Region versus the Russian Federation.Subjects and methods. The investigators used the 2002–2010 statistical guidelines “Prevalence of diseases in adult populationof Russia” by the Ministry of Health of Russia; the 2006–2010 federal statistical inquiry forms No. 14 in the Tula Region and the Russian Federation; the European hospital database; the 2000–2011 mortality databases in the Tula Region, which had been obtained by the automated mortality registration systems, which contained 373,997 records and included all margins of “Medical Death Certificates”.Results and discussion. In the Russian Federation, overall prevalence of AS per 100,000 adult population increased from 27.6 in 2002 to 34.4 in 2010 (the increment was 24.6% while in the Tula Region its trend was unstable in this period. Incidence of AS here decreased by 31.8% from 2002 to 2010; in Russia its increment was 51.6%. From 2000 to 2011 in the Tula Region AS was registered as one of the causes of death in 29 cases.Conclusion. To plan measures aimed at improving the quality of medical care to AS patients, it is necessary to expand a comprehensive study of AS prevalence as well as outpatient and inpatient mortality from AS

  20. Preschool executive functioning abilities predict early mathematics achievement.

    Science.gov (United States)

    Clark, Caron A C; Pritchard, Verena E; Woodward, Lianne J

    2010-09-01

    Impairments in executive function have been documented in school-age children with mathematical learning difficulties. However, the utility and specificity of preschool executive function abilities in predicting later mathematical achievement are poorly understood. This study examined linkages between children's developing executive function abilities at age 4 and children's subsequent achievement in mathematics at age 6, 1 year after school entry. The study sample consisted of a regionally representative cohort of 104 children followed prospectively from ages 2 to 6 years. At age 4, children completed a battery of executive function tasks that assessed planning, set shifting, and inhibitory control. Teachers completed the preschool version of the Behavior Rating Inventory of Executive Function. Clinical and classroom measures of children's mathematical achievement were collected at age 6. Results showed that children's performance on set shifting, inhibitory control, and general executive behavior measures during the preschool period accounted for substantial variability in children's early mathematical achievement at school. These associations persisted even after individual differences in general cognitive ability and reading achievement were taken into account. Findings suggest that early measures of executive function may be useful in identifying children who may experience difficulties learning mathematical skills and concepts. They also suggest that the scaffolding of these executive skills could potentially be a useful additional component in early mathematics education.

  1. Limited feedback achieves the empirical capacity

    CERN Document Server

    Eswaran, Krishnan; Sahai, Anant; Gastpar, Michael

    2007-01-01

    The utility of limited feedback for coding over an individual sequence of DMCs is investigated. This study complements recent results showing how limited or noisy feedback can boost the reliability of communication. A strategy with fixed input distribution $P$ is given that asymptotically achieves rates arbitrarily close to the mutual information induced by $P$ and the state-averaged channel. When the capacity achieving input distribution is the same over all channel states, this achieves rates at least as large as the capacity of the state averaged channel, sometimes called the empirical capacity.

  2. Disparity in academic achievement

    African Journals Online (AJOL)

    User

    female and male students in colleges of teachers' education in Oromia, and to identify variables attributing to ... and social services (Dereje, Dawit & ... related to student attitudes (motivation; .... community commitment to children's ... and getting involved in social and academic .... study, and gender patterns in achievement.

  3. Iowa Women of Achievement.

    Science.gov (United States)

    Ohrn, Deborah Gore, Ed.

    1993-01-01

    This issue of the Goldfinch highlights some of Iowa's 20th century women of achievement. These women have devoted their lives to working for human rights, education, equality, and individual rights. They come from the worlds of politics, art, music, education, sports, business, entertainment, and social work. They represent Native Americans,…

  4. Assessing Handwriting Achievement.

    Science.gov (United States)

    Ediger, Marlow

    Teachers in the school setting need to emphasize quality handwriting across the curriculum. Quality handwriting means that the written content is easy to read in either manuscript or cursive form. Handwriting achievement can be assessed, but not compared to the precision of assessing basic addition, subtraction, multiplication, and division facts.…

  5. NCLB: Achievement Robin Hood?

    Science.gov (United States)

    Bracey, Gerald W.

    2008-01-01

    In his "Wall Street Journal" op-ed on the 25th of anniversary of "A Nation At Risk", former assistant secretary of education Chester E. Finn Jr. applauded the report for turning U.S. education away from equality and toward achievement. It was not surprising, then, that in mid-2008, Finn arranged a conference to examine the…

  6. Cognitive Processes and Achievement.

    Science.gov (United States)

    Hunt, Dennis; Randhawa, Bikkar S.

    For a group of 165 fourth- and fifth-grade students, four achievement test scores were correlated with success on nine tests designed to measure three cognitive functions: sustained attention, successive processing, and simultaneous processing. This experiment was designed in accordance with Luria's model of the three functional units of the…

  7. Cognitive Processes and Achievement.

    Science.gov (United States)

    Hunt, Dennis; Randhawa, Bikkar S.

    For a group of 165 fourth- and fifth-grade students, four achievement test scores were correlated with success on nine tests designed to measure three cognitive functions: sustained attention, successive processing, and simultaneous processing. This experiment was designed in accordance with Luria's model of the three functional units of the…

  8. NCLB: Achievement Robin Hood?

    Science.gov (United States)

    Bracey, Gerald W.

    2008-01-01

    In his "Wall Street Journal" op-ed on the 25th of anniversary of "A Nation At Risk", former assistant secretary of education Chester E. Finn Jr. applauded the report for turning U.S. education away from equality and toward achievement. It was not surprising, then, that in mid-2008, Finn arranged a conference to examine the…

  9. White ash (Fraxinus americana) health in the Allegheny plateau region, Pennsylvania: Evaluating the relationship between FIA phase 3 crown variables and a categorical rating system

    Science.gov (United States)

    Alejandro A. Royo; Kathleen S. Knight; Jamie M. Himes; Ashley N. Will

    2012-01-01

    Following the detection of white ash (Fraxinus americana) decline in the Allegheny National Forest (ANF) of Pennsylvania, we established an intensified white ash monitoring network throughout the ANF. We rated crowns using both a categorical system as well as Forest Inventory and Analyses (FIA) Phase 3 measures of uncompacted live crown ratio,...

  10. Applications of ERTS-1 Data Collection System (DCS) in the Arizona Regional Ecological Test Site (ARETS). [water management, streamflow rates, flood control

    Science.gov (United States)

    Schumann, H. H. (Principal Investigator)

    1973-01-01

    The author has identified the following significant results. The DCS water-stage data from the USGS streamflow gaging station on the Verde River near Camp Verde furnished information sufficient for the accurate computation of daily mean streamflow rates during the first 2 months of operation. Daily mean flow rates computed from the DCS data agreed with those computed from the digital recorder data within + or - 5% during periods of stable or slowly changing flow and within + or - 10% during periods of rapidly changing high flow. The SRP was furnished near-real time DCS information on snow moisture content and streamflow rates for use in the management and operation of the multiple-use reservoir system. The SRP, by prudent water management and the use of near-real time hydrologic data furnished by microwave and ERTS DCS telemetry, was successful in anticipating the amount of flow into the Salt and Verde Rivers and in the subsequent release of water at rates that did not create flooding in metropolitan Phoenix. Only minor flooding occurred along the Gila River west of Phoenix. According to the Maricopa County Civil Defense agency, wage and salary losses of about $11,400,000 resulted from closing of roads across the Salt River in the winter and spring of 1972-73; however, the number and duration of the closing were minimized by use of DCS data.

  11. New Achievements in a Systematic Regional Survey of the Rizhao Area in Shandong%山东日照地区系统区域调查的新收获

    Institute of Scientific and Technical Information of China (English)

    中美两城地区联合考古队

    2002-01-01

    Settlement archaeology is an effective means for studying the birth and development of the early social organization, and also an important approach for researching into the origin of civilization. Since 1995, in cooperation with Yale University and the Field Museum in Chicago, U. S. A.,Shandong University has carried out a long-term systematic regional survey in the Rizhao area of Shandong Province. The work has gained plentiful results and valuable experience for searching field archaeological methods appropriate to Chinese practice. The present paper introduces briefly the area,purpose and method of survey in this research project and makes a preliminary summary of the fruits gained in the first five years.

  12. Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a mouse model of neonatal hypoxic-ischemic brain injury

    Directory of Open Access Journals (Sweden)

    Mizuya eShinoyama

    2013-08-01

    Full Text Available Hypoxic–ischemic encephalopathy (HIE at birth could cause cerebral palsy, mental retardation, and epilepsy, which last throughout the individual’s lifetime. However, few restorative treatments for ischemic tissue are currently available. Cell replacement therapy offers the potential to rescue brain damage caused by HI and to restore motor function. In the present study, we evaluated the ability of embryonic stem cell-derived neural progenitor cells (ES-NPCs to become cortical deep layer neurons, to restore the neural network, and to repair brain damage in an HIE mouse model. ES cells stably expressing the reporter gene GFP are induced to a neural precursor state by stromal cell co-culture. Forty-hours after the induction of HIE, animals were grafted with ES-NPCs targeting the deep layer of the motor cortex in the ischemic brain. Motor function was evaluated 3 weeks after transplantation. Immunohistochemistry and neuroanatomical tracing with GFP were used to analyze neuronal differentiation and axonal sprouting. ES-NPCs could differentiate to cortical neurons with pyramidal morphology and expressed the deep layer-specific marker, Ctip2. The graft showed good survival and an appropriate innervation pattern via axonal sprouting from engrafted cells in the ischemic brain. The motor functions of the transplanted HIE mice also improved significantly compared to the sham-transplanted group. These findings suggest that cortical region specific engraftment of preconditioned cortical precursor cells could support motor functional recovery in the HIE model. It is not clear whether this is a direct effect of the engrafted cells or due to neurotrophic factors produced by these cells. These results suggest that cortical region-specific NPC engraftment is a promising therapeutic approach for brain repair.

  13. Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a mouse model of neonatal hypoxic-ischemic brain injury.

    Science.gov (United States)

    Shinoyama, Mizuya; Ideguchi, Makoto; Kida, Hiroyuki; Kajiwara, Koji; Kagawa, Yoshiteru; Maeda, Yoshihiko; Nomura, Sadahiro; Suzuki, Michiyasu

    2013-01-01

    Hypoxic-ischemic encephalopathy (HIE) at birth could cause cerebral palsy (CP), mental retardation, and epilepsy, which last throughout the individual's lifetime. However, few restorative treatments for ischemic tissue are currently available. Cell replacement therapy offers the potential to rescue brain damage caused by HI and to restore motor function. In the present study, we evaluated the ability of embryonic stem cell-derived neural progenitor cells (ES-NPCs) to become cortical deep layer neurons, to restore the neural network, and to repair brain damage in an HIE mouse model. ES cells stably expressing the reporter gene GFP are induced to a neural precursor state by stromal cell co-culture. Forty-hours after the induction of HIE, animals were grafted with ES-NPCs targeting the deep layer of the motor cortex in the ischemic brain. Motor function was evaluated 3 weeks after transplantation. Immunohistochemistry and neuroanatomical tracing with GFP were used to analyze neuronal differentiation and axonal sprouting. ES-NPCs could differentiate to cortical neurons with pyramidal morphology and expressed the deep layer-specific marker, Ctip2. The graft showed good survival and an appropriate innervation pattern via axonal sprouting from engrafted cells in the ischemic brain. The motor functions of the transplanted HIE mice also improved significantly compared to the sham-transplanted group. These findings suggest that cortical region specific engraftment of preconditioned cortical precursor cells could support motor functional recovery in the HIE model. It is not clear whether this is a direct effect of the engrafted cells or due to neurotrophic factors produced by these cells. These results suggest that cortical region-specific NPC engraftment is a promising therapeutic approach for brain repair.

  14. Viscoelastic Response of the Titanium Alloy Ti-6-4: Experimental Identification of Time- and Rate-Dependent Reversible and Irreversible Deformation Regions

    Science.gov (United States)

    Lerch, Bradley A.; Arnold, Steven M.

    2014-01-01

    In support of an effort on damage prognosis, the viscoelastic behavior of Ti-6Al-4V (Ti-6-4) was investigated. This report documents the experimental characterization of this titanium alloy. Various uniaxial tests were conducted to low load levels over the temperature range of 20 to 538 C to define tensile, creep, and relaxation behavior. A range of strain rates (6x10(exp -7) to 0.001/s) were used to document rate effects. All tests were designed to include an unloading portion, followed by a hold time at temperature to allow recovery to occur either at zero stress or strain. The titanium alloy was found to exhibit viscoelastic behavior below the "yield" point and over the entire range of temperatures (although at lower temperatures the magnitude is extremely small). These experimental data will be used for future characterization of a viscoelastic model.

  15. The Dzhungarian fault: Late Quaternary tectonics and slip rate of a major right-lateral strike-slip fault in the northern Tien Shan region

    OpenAIRE

    Campbell, G. E.; Walker, R T; Abdrakhmatov, K.; Schwenninger, J.L.; Jackson, J.; Elliott, J R; Copley, A

    2013-01-01

    This is the final version of the article, originally published in the Journal of Geophysical Research: Solid Earth. It is also available from Wiley at http://onlinelibrary.wiley.com/doi/10.1002/jgrb.50367/abstract. © 2013. American Geophysical Union The Dzhungarian strike-slip fault of Central Asia is one of a series of long, NW-SE right-lateral strike-slip faults that are characteristic of the northern Tien Shan region and extends over 300 km from the high mountains into the Kazakh Pl...

  16. Interest Rate Liberalization in Less Developed Regions and Path Selection%欠发达地区利率市场化现状及路径选择——以贵州省为例

    Institute of Scientific and Technical Information of China (English)

    郝曙光

    2012-01-01

    "十二五"期间,我国将继续稳步推进利率市场化改革,如何引导金融机构做好利率市场化的准备工作成为当前欠发达地区需要解决的重要课题。本文以贵州省为例,首先介绍了贵州省利率市场化的基本情况,然后分析贵州省利率市场化过程中存在的主要问题,最后结合实际提出了欠发达地区利率市场化的路径选择。%In 'The Twelfth Five-Year Plan' period, China will continue to steadily promote the interest rate liberalization reform. For this reason, how to guide financial institutions to prepare for the interest rate liberalization has become an important issue in the less developed regions. This paper takes Guizhou province as an example. Firstly, it introduces the basic conditions of the interest rate liberalization, then analyzes the main problems existing in the process of interest rate liberalization, and finally puts forward path selection of the interest rate liberalization in less developed regions.

  17. Improved Helicobacter pylori Eradication Rate of Tailored Triple Therapy by Adding Lactobacillus delbrueckii and Streptococcus thermophilus in Northeast Region of Thailand: A Prospective Randomized Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Taweesak Tongtawee

    2015-01-01

    Full Text Available Background and Aim. To evaluate the effect of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus to Helicobacter pylori eradication in different periods of therapeutic protocol. Methods. Infected patients were randomized to one-week tailored triple therapy (esomeprazole 20 mg bid, clarithromycin 500 mg bid/metronidazole 400 mg tid if clarithromycin resistant, and amoxicillin 1000 mg bid with placebo (group 1, n=100; one week of pretreatment with probiotics (group 2, n=100; and one week of pretreatment with probiotic followed by one week of the same probiotics after treatment (group 3, n=100. Result. PP analysis involved 292 patients, 98 in group 1, 97 in group 2, and 97 in group 3. Successful eradication was observed in 229 patients; by PP analysis, the eradication rates were significantly higher (P<0.01, 95% CI; 0.71–0.97 in group 2 and group 3 than group 1. ITT analysis eradication rates were significantly higher in group 2 and group 3 than group 1 (P<0.01 95% CI; 0.72–0.87, and there is no significant difference between the three groups (P=0.32 in terms of adverse events. Conclusion. Adding probiotics before or before and after tailored treatment can improve Helicobacter pylori eradication rates. This trial is registered with Thai Clinical Trials Registry number: TCTR20141209001.

  18. Achieveing Organizational Excellence Through

    Directory of Open Access Journals (Sweden)

    Mehdi Abzari

    2009-04-01

    Full Text Available AbstractToday, In order to create motivation and desirable behavior in employees, to obtain organizational goals,to increase human resources productivity and finally to achieve organizational excellence, top managers oforganizations apply new and effective strategies. One of these strategies to achieve organizational excellenceis creating desirable corporate culture. This research has been conducted to identify the path to reachorganizational excellence by creating corporate culture according to the standards and criteria oforganizational excellence. The result of the so-called research is this paper in which researchers foundtwenty models and components of corporate culture and based on the Industry, organizational goals andEFQM model developed a model called "The Eskimo model of Culture-Excellence". The method of theresearch is survey and field study and the questionnaires were distributed among 116 managers andemployees. To assess the reliability of questionnaires, Cronbach alpha was measured to be 95% in the idealsituation and 0/97 in the current situation. Systematic sampling was done and in the pre-test stage 45questionnaires were distributed. A comparison between the current and the ideal corporate culture based onthe views of managers and employees was done and finally it has been concluded that corporate culture isthe main factor to facilitate corporate excellence and success in order to achieve organizational effectiveness.The contribution of this paper is that it proposes a localized –applicable model of corporate excellencethrough reinforcing corporate culture.

  19. High sedimentation rates in the Early Triassic after latest Permian mass extinction: Carbonate production is main factor in non-Arctic regions

    Science.gov (United States)

    Horacek, Micha; Brandner, Rainer

    2016-04-01

    A substantial change in sedimentation rates towards higher values has been documented from the Late Permian to the Lower Triassic. Although it is assumed and also has been shown that the deposition of siliciclastic material increased in the Lower Triassic due to stronger erosion because of loss of land cover and increased chemical and physical weathering with extreme climate warming, the main sediment production occurred by marine carbonate production. Still, carbonate production might have been significantly influenced by weathering and erosion in the hinterland, as the transport of dust by storms into the ocean water probably was a main nutrient source for microbial carbonate producers, because "normal" nutrient supply by ocean circulation, i. e. upwelling was strongly reduced due to the elevated temperatures resulting in water-column stratification . Sediment accumulation was also clearly influenced by the paleo-geographic and latitudinal position, with lower carbonate production and sedimentation rates in moderate latitudes. The existence of a "boundary clay" and microbial carbonate mounds and layers in the immediate aftermath of the latest Permian mass extinction points towards a development from a short-timed acid ocean water - resulting in a carbonate production gap and the deposition of the boundary clay towards the deposition of the microbial mounds and layers due to the microbial production of micro-environments with higher alkalinity allowing the production of carbonate. After the return of the ocean water to normal alkalinity planktic production of carbonate resulted in a very high sedimentation rate, especially taking into account the absence of carbonate producing eukaryotic algae and animals.

  20. Regional changes in charcoal-burning suicide rates in East/Southeast Asia from 1995 to 2011: a time trend analysis.

    OpenAIRE

    Shu-Sen Chang; Ying-Yeh Chen; Paul S F Yip; Won Jin Lee; Akihito Hagihara; David Gunnell

    2014-01-01

    Editors' Summary Background Every year, almost one million people die by suicide globally; suicide is the fifth leading cause of death in women aged 15–49 and the sixth leading cause of death in men in the same age group. Most people who take their own life are mentally ill. For others, stressful events (the loss of a partner, for example) have made life seem worthless or too painful to bear. Strategies to reduce suicide rates include better treatment of mental illness and programs that help ...

  1. Deflation rates of different clastic sediments in the arid regions of China%中国干旱区不同成因碎屑沉积物的吹蚀速率研究

    Institute of Scientific and Technical Information of China (English)

    宋阳; 刘连友; 李晓燕

    2006-01-01

    By wind tunnel experiment, we studied the deflation rates of 8 different clastic sediments in the arid regions of China, discussed the sources of aeolian sand and their influence on the development of sand dunes and formation of sand deserts from the view of dynamics of wind erosion. The average deflation rates of 8 typical clastic sediments in the arid regions of China can be arranged in the order of lacustrine sand > alluvial sand > weathered sandstone and shale > pluvial sediments > fluvioglacial sand > weathered granite > slope deposit > glacial sediments. The deflation rates exhibited strong positive correlations with the erodible particle (0.063-2mm) content and sorting features. In contrast, the deflation rates had obvious negative correlations with the contents of silt clay (<0.063 mm) and gravel (>2 mm). According to the deflation rates, the 8 typical clastic sediments can be divided into four categories: (1) lacustrine and alluvial sand, which are readily prone to wind erosion, assumed to be the main source of aeolian sand; (2) weathered sandstone and shale, pluvial sediments and fluvioglacial sand with considerable deflation rates, might be the secondary source of aeolian sand; (3) weathered granite and slope deposit having the lower deflation rates, could supply a little aeolian sand; and (4) glacial sediments with a strong anti-erodibility, could hardly offer any aeolian sand. In addition to the strong wind conditions, the exposure of extensive lacustrine sand induced by the desiccation of inland lake basin, as well as the pre-sorting of clastic sediments by flowing water should be the key factors influencing the development of sand deserts in China. The possible reason the sand deserts in China being mostly distributed around the inland lake basins and along riverbanks could be better understood through sand source analysis.

  2. Transfer of Technology in Determining Lowest Achievable Emission Rate (LAER)

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  3. Achievable Information Rates on Linear Interference Channels with Discrete Input

    DEFF Research Database (Denmark)

    Yankov, Metodi Plamenov; Forchhammer, Søren

    2015-01-01

    In this paper lower bound on the capacity of multi-dimensional linear interference channels is derived, when the input is taken from a finite size alphabet. The bounds are based on the QR decomposition of the channel matrix, and hold for any input distribution that is independent across dimensions...

  4. Determination of Lowest Achievable Emission Rate for Coors Container Corporation

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  5. Impact of initial models and variable accretion rates on the pre-main-sequence evolution of massive and intermediate-mass stars and the early evolution of H II regions

    Science.gov (United States)

    Haemmerlé, Lionel; Peters, Thomas

    2016-05-01

    Massive star formation requires the accretion of gas at high rate while the star is already bright. Its actual luminosity depends sensitively on the stellar structure. We compute pre-main-sequence tracks for massive and intermediate-mass stars with variable accretion rates and study the evolution of stellar radius, effective temperature and ionizing luminosity, starting at 2 M⊙ with convective or radiative structures. The radiative case shows a much stronger swelling of the protostar for high accretion rates than the convective case. For radiative structures, the star is very sensitive to the accretion rate and reacts quickly to accretion bursts, leading to considerable changes in photospheric properties on time-scales as short as 100-1000 yr. The evolution for convective structures is much less influenced by the instantaneous accretion rate, and produces a monotonically increasing ionizing flux that can be many orders of magnitude smaller than in the radiative case. For massive stars, it results in a delay of the H II region expansion by up to 10 000 yr. In the radiative case, the H II region can potentially be engulfed by the star during the swelling, which never happens in the convective case. We conclude that the early stellar structure has a large impact on the radiative feedback during the pre-main-sequence evolution of massive protostars and introduces an important uncertainty that should be taken into account. Because of their lower effective temperatures, our convective models may hint at a solution to an observed discrepancy between the luminosity distribution functions of massive young stellar objects and compact H II regions.

  6. Potential of VIS-NIR-SWIR Spectroscopy from the Chinese Soil Spectral Library for Assessment of Nitrogen Fertilization Rates in the Paddy-Rice Region, China

    Directory of Open Access Journals (Sweden)

    Shuo Li

    2015-05-01

    Full Text Available To meet growing food demand with limited land and reduced environmental impact, soil testing and formulated fertilization methods have been widely adopted around the world. However, conventional technology for investigating nitrogen fertilization rates (NFR is time consuming and expensive. Here, we evaluated the use of visible near-infrared shortwave-infrared (VIS-NIR-SWIR: 400–2500 nm spectroscopy for the assessment of NFR to provide necessary information for fast, cost-effective and precise fertilization rating. Over 2000 samples were collected from paddy-rice fields in 10 Chinese provinces; samples were added to the Chinese Soil Spectral Library (CSSL. Two kinds of modeling strategies for NFR, quantitative estimation of soil N prior to classification and qualitative by classification, were employed using partial least squares regression (PLSR, locally weighted regression (LWR, and support vector machine discriminant analogy (SVMDA. Overall, both LWR and SVMDA had moderate accuracies with Cohen’s kappa coefficients of 0.47 and 0.48, respectively, while PLSR had fair accuracy (0.37. We conclude that VIS-NIR-SWIR spectroscopy coupled with the CSSL appears to be a viable, rapid means for the assessment of NFR in paddy-rice soil. Based on qualitative classification of soil spectral data only, it is recommended that the SVMDA be adopted for rapid implementation.

  7. Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. V. A New Size-Luminosity Scaling Relation for the Broad-Line Region

    CERN Document Server

    Du, Pu; Zhang, Zhi-Xiang; Huang, Ying-Ke; Wang, Kai; Hu, Chen; Qiu, Jie; Li, Yan-Rong; Fan, Xu-Liang; Fang, Xiang-Er; Bai, Jin-Ming; Bian, Wei-Hao; Yuan, Ye-Fei; Ho, Luis C; Wang, Jian-Min

    2016-01-01

    This paper reports results of the third-year campaign of monitoring super-Eddington accreting massive black holes (SEAMBHs) in active galactic nuclei (AGNs) between 2014-2015. Ten new targets were selected from quasar sample of Sloan Digital Sky Survey (SDSS), which are generally more luminous than the SEAMBH candidates in last two years. H$\\beta$ lags ($\\tau_{_{\\rm H\\beta}}$) in five of the 10 quasars have been successfully measured in this monitoring season. We find that the lags are generally shorter, by large factors, than those of objects with same optical luminosity, in light of the well-known $R_{_{\\rm H\\beta}}-L_{5100}$ relation. The five quasars have dimensionless accretion rates of $\\dot{\\mathscr{M}}=10-10^3$. Combining measurements of the previous SEAMBHs, we find that the reduction of H$\\beta$ lags tightly depends on accretion rates, $\\tau_{_{\\rm H\\beta}}/\\tau_{_{R-L}}\\propto\\dot{\\mathscr{M}}^{-0.42}$, where $\\tau_{_{R-L}}$ is the H$\\beta$ lag from the normal $R_{_{\\rm H\\beta}}-L_{5100}$ relation....

  8. Achieving form in autobiography

    Directory of Open Access Journals (Sweden)

    Nicholas (Nick Meihuizen

    2014-06-01

    Full Text Available This article argues that, unlike biographies which tend to follow patterns based on conventional expectations, salient autobiographies achieve forms unique to themselves. The article draws on ideas from contemporary formalists such as Peter McDonald and Angela Leighton but also considers ideas on significant form stemming from earlier writers and critics such as P.N. Furbank and Willa Cather. In extracting from these writers the elements of what they consider comprise achieved form, the article does not seek to provide a rigid means of objectively testing the formal attributes of a piece of writing. It rather offers qualitative reminders of the need to be alert to the importance of form, even if the precise nature of this importance is not possible to define. Form is involved in meaning, and this continuously opens up possibilities regarding the reader’s relationship with the work in question. French genetic critic Debray Genette distinguishes between ‘semantic effect’ (the direct telling involved in writing and ‘semiological effect’ (the indirect signification involved. It is the latter, the article argues in summation, which gives a work its singular nature, producing a form that is not predictable but suggestive, imaginative.

  9. READOUT ELECTRONICS FOR A HIGH-RATE CSC DETECTOR

    Energy Technology Data Exchange (ETDEWEB)

    OCONNOR,P.; GRATCHEV,V.; KANDASAMY,A.; POLYCHRONAKOS,V.; TCHERNIATINE,V.; PARSONS,J.; SIPPACH,W.

    1999-09-25

    A readout system for a high-rate muon Cathode Strip Chamber (CSC) is described. The system, planned for use in the forward region of the ATLAS muon spectrometer, uses two custom CMOS integrated circuits to achieve good position resolution at a flux of up to 2,500 tracks/cm{sup 2}/s.

  10. Achieving English Spoken Fluency

    Institute of Scientific and Technical Information of China (English)

    王鲜杰

    2000-01-01

    Language is first and foremost oral,spoken language,speaking skill is the most important one of the four skills(L,S,R,W)and also it is the most difficult one of the four skills. To have an all-round command of a language one must be able to speak and to understand the spoken language, it is not enough for a language learner only to have a good reading and writing skills. As Englisn language teachers, we need to focus on improving learners' English speaking skill to meet the need of our society and our country and provide learner some useful techniques to achieving their English spoken fluency. This paper focuses on the spoken how to improving learners speaking skill.

  11. Achieving diagnosis by consensus

    LENUS (Irish Health Repository)

    Kane, Bridget

    2009-08-01

    This paper provides an analysis of the collaborative work conducted at a multidisciplinary medical team meeting, where a patient’s definitive diagnosis is agreed, by consensus. The features that distinguish this process of diagnostic work by consensus are examined in depth. The current use of technology to support this collaborative activity is described, and experienced deficiencies are identified. Emphasis is placed on the visual and perceptual difficulty for individual specialities in making interpretations, and on how, through collaboration in discussion, definitive diagnosis is actually achieved. The challenge for providing adequate support for the multidisciplinary team at their meeting is outlined, given the multifaceted nature of the setting, i.e. patient management, educational, organizational and social functions, that need to be satisfied.

  12. Recognizing outstanding achievements

    Science.gov (United States)

    Speiss, Fred

    One function of any professional society is to provide an objective, informed means for recognizing outstanding achievements in its field. In AGU's Ocean Sciences section we have a variety of means for carrying out this duty. They include recognition of outstanding student presentations at our meetings, dedication of special sessions, nomination of individuals to be fellows of the Union, invitations to present Sverdrup lectures, and recommendations for Macelwane Medals, the Ocean Sciences Award, and the Ewing Medal.Since the decision to bestow these awards requires initiative and judgement by members of our section in addition to a deserving individual, it seems appropriate to review the selection process for each and to urge you to identify those deserving of recognition.

  13. Achieving closure at Fernald

    Energy Technology Data Exchange (ETDEWEB)

    Bradburne, John; Patton, Tisha C.

    2001-02-25

    When Fluor Fernald took over the management of the Fernald Environmental Management Project in 1992, the estimated closure date of the site was more than 25 years into the future. Fluor Fernald, in conjunction with DOE-Fernald, introduced the Accelerated Cleanup Plan, which was designed to substantially shorten that schedule and save taxpayers more than $3 billion. The management of Fluor Fernald believes there are three fundamental concerns that must be addressed by any contractor hoping to achieve closure of a site within the DOE complex. They are relationship management, resource management and contract management. Relationship management refers to the interaction between the site and local residents, regulators, union leadership, the workforce at large, the media, and any other interested stakeholder groups. Resource management is of course related to the effective administration of the site knowledge base and the skills of the workforce, the attraction and retention of qualified a nd competent technical personnel, and the best recognition and use of appropriate new technologies. Perhaps most importantly, resource management must also include a plan for survival in a flat-funding environment. Lastly, creative and disciplined contract management will be essential to effecting the closure of any DOE site. Fluor Fernald, together with DOE-Fernald, is breaking new ground in the closure arena, and ''business as usual'' has become a thing of the past. How Fluor Fernald has managed its work at the site over the last eight years, and how it will manage the new site closure contract in the future, will be an integral part of achieving successful closure at Fernald.

  14. Achievement Goals and Achievement Emotions: A Meta-Analysis

    Science.gov (United States)

    Huang, Chiungjung

    2011-01-01

    This meta-analysis synthesized 93 independent samples (N = 30,003) in 77 studies that reported in 78 articles examining correlations between achievement goals and achievement emotions. Achievement goals were meaningfully associated with different achievement emotions. The correlations of mastery and mastery approach goals with positive achievement…

  15. Relative Abundance and Plasmodium Infection Rates of Malaria Vectors in and around Jabalpur, a Malaria Endemic Region in Madhya Pradesh State, Central India.

    Directory of Open Access Journals (Sweden)

    Neeru Singh

    Full Text Available This study was undertaken in two Primary Health Centers (PHCs of malaria endemic district Jabalpur in Madhya Pradesh (Central India.In this study we had investigated the relative frequencies of the different anopheline species collected within the study areas by using indoor resting catches, CDC light trap and human landing methods. Sibling species of malaria vectors were identified by cytogenetic and molecular techniques. The role of each vector and its sibling species in the transmission of the different Plasmodium species was ascertained by using sporozoite ELISA.A total of 52,857 specimens comprising of 17 anopheline species were collected by three different methods (39,964 by indoor resting collections, 1059 by human landing and 11,834 by CDC light trap. Anopheles culicifacies was most predominant species in all collections (55, 71 and 32% in indoor resting, human landing and light trap collections respectively followed by An. subpictus and An. annularis. All five sibling species of An. culicifacies viz. species A, B, C, D and E were found while only species T and S of An. fluviatilis were collected. The overall sporozoite rate in An. culicifacies and An. fluviatilis were 0.42% (0.25% for P. falciparum and 0.17% for P. vivax and 0.90% (0.45% for P. falciparum and 0.45% for P. vivax respectively. An. culicifacies and An. fluviatilis were found harbouring both P. vivax variants VK-210 and VK-247, and P. falciparum. An. culicifacies sibling species C and D were incriminated as vectors during most part of the year while sibling species T of An. fluviatilis was identified as potential vector in monsoon and post monsoon season.An. culicifacies species C (59% was the most abundant species followed by An. culicifacies D (24%, B (8.7%, E (6.7% and A (1.5%. Among An. fluviatilis sibling species, species T was common (99% and only few specimens of S were found. Our study provides crucial information on the prevalence of An. culicifacies and An

  16. Investigations of excretion rates of the radionuclides {sup 230}Th, {sup 226}Ra, {sup 210}Pb and {sup 210}Po of persons of the general population and of workers in selected regions in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, I. [Nuclear Engineering and Analytics Rossendorf Inc. D-01328 Dresden (Germany); Seitz, G. [Institution for statutory accident insurance and prevention in the precision engineering and electrical industry, D-50941 Koeln (Germany); Hartmann, M. [Federal Office for Radiation Protection, D-10318 Berlin (Germany)

    2006-07-01

    According to ICRP 60 and European-Directive 96/29, Naturally Occurring Radioactive Materials (NORM) and Technical Enriched Naturally Occurring Radioactive Materials (TENORM) have to take the radiation protection of the general population as well as of workers into account. The German radiation protection regulations stress that particularly. In connection with these regulations, various measurement programs have been and still are performed to investigate the relevant exposure paths. One of these programs is the determination of the intake of natural occurring radionuclides of the uranium decay series in individuals of the public, in exposed regions and houses and also at NORM workplaces by excretion analysis. Excretion analysis surveillance is one of the common tools for internal dosimetry. Sources of primordial radionuclides could be the ingestion of foodstuff and water and the incorporation of (mostly airborne) pollution on work places. The main focus in this report is set upon the excretion rate in faeces and urine. A cohort of about 100 persons was selected in five regions in Germany. One of these regions we chose to be the reference area. It is situated in the northern part of Germany with low background radiation. The other regions are in the south-west and south-east mountain areas. Workers were selected from drinking water providers, natural gas providers, balneologic facilities and exhibition mines and museum pits. In the same region also persons of public were recruited for the study. The paper presents selected data of the above mentioned nuclides in urine and faeces samples which were collected during 2002 to 2005. The results are grouped due the parameters like regions and working fields and are discussed in detail. These are 15 mBq/d in urine and 70 mBq/d in faeces and are not as different for the different nuclides as one may expect. (authors)

  17. Vietnam: achievements and challenges.

    Science.gov (United States)

    Tran Tien Duc

    1999-01-01

    The Vietnamese Government's successful development of the National Population and Family Planning Program has contributed in raising people's awareness on population issues and changing their attitudes and behavior regarding fostering small families. It has also been found to be very effective in substantially decreasing fertility level. In addition, economic levels of many households have been greatly improved since the adoption of a renovation policy. The advancement of welfare accompanied by the provision of better basic social services, including health services, has boost people's health. Several factors behind the achievements of the National Population and Family Planning Program include: 1) Strengthening of the political commitment of national and local leaders; 2) Nationwide mobilization of mass organizations and NGOs; 3) A strong advocacy and information, education and communication program; 4) Provision of various kinds of contraceptives; 5) Effective management of the program by priority; and 6) Support of the international community. Despite such successes, Vietnam is facing a number of new issues such as enlargement of the work force, shifting migration patterns and accelerating urbanization, aging of population, and change of household structure. Nevertheless, the Government of Vietnam is preparing a New Population Strategy aimed to address these issues.

  18. Evaluation on Surveillance of Routine Immunization Coverage Rate in Inner Mongolia Autonomous Region in 2011%内蒙古自治区2011年常规免疫接种率监测结果评价

    Institute of Scientific and Technical Information of China (English)

    郭广亮; 武贵森; 田晓灵; 范耀春

    2013-01-01

    Objective To get the information about routine immunization coverage in Inner Mongolia Autonomous Region,and to evaluate the surveillance data.Methods The surveillance data were compared and analyzed by difference-value method and ratio-value method.Results The reported immunization coverage rates of BCG,DPT,HepB,PV,MCV and JE were all higher than 99%,while the estimated rates were all lower than 95%.The results of R value evaluation in Inner Mongolia Autonomous Region were credible,while those of D value evaluation were unreliable.Conclusions The reality and accuracy of the reported routine immunization coverage rates in Inner Mongolia Autonomous Region need to be improved.%目的 了解内蒙古自治区2011年常规免疫接种情况,对常规免疫接种率监测结果进行评价. 方法 通过差值法和比值法对监测结果进行比较分析. 结果 内蒙古全区卡介苗(BCG)、百白破疫苗(DPT)、乙肝疫苗(HepB)、脊髓灰质炎疫苗(PV)、麻类疫苗(MCV)和乙脑疫苗(JE)六苗常规免疫报告接种率均高于99%,估算接种率均小于95%.全区D值评价为不可信,R值评价为可信. 结论 内蒙古常规免疫接种率报告真实性、准确性有待提高.

  19. Credit rating dynamics and competition

    DEFF Research Database (Denmark)

    Hirth, Stefan

    2014-01-01

    I analyze the market for credit ratings with competition between more than two rating agencies. How can honest rating behavior be achieved, and under which conditions can a new honest rating agency successfully invade a market with inflating incumbents? My model predicts cyclic dynamics if sophis......I analyze the market for credit ratings with competition between more than two rating agencies. How can honest rating behavior be achieved, and under which conditions can a new honest rating agency successfully invade a market with inflating incumbents? My model predicts cyclic dynamics...

  20. ACHIEVING OPTIMAL SCHOOL CLIMATE

    Directory of Open Access Journals (Sweden)

    Nizar SHIHADI

    2015-11-01

    Full Text Available Development of optimal school climate is the basis of educational, social and moral work in school. Optimal educa-tional climate in a school is a condition for learning and development of all those attending the educational establishment (pupils, teachers and parents. The school is responsible for the personal, cognitive, emotional, social and moral develop-ment of pupils. The educational team has the ability and commitment to promote an educational climate. Improvement of study achievements of pupils is related, as well as conditional, to optimal climate. "A climate in an educational establishment is a key factor that affects the creation of environment which develops personal security and sense of affiliation, value and mutual respect" [12].FORMAREA UNEI ATMOSFERE OPTIMALE ÎN ŞCOALĂ Formarea unei atmosfere optimale în şcoala medie este baza lucrului educaţional, social şi moral în şcoală. Atmosfera educaţională în şcoală este o condiţie pentru instruirea şi dezvoltarea tuturor celor înrolaţi în instituţia educaţională (elevi, profesori şi părinţi. Şcoala poartă răspundere de condiţiile favorabile în dezvoltarea personală, cognitivă, emoţională, socială şi morală a elevilor. Echipa de profesori are abilitatea şi angajamentul de a promova condiţii educaţionale favorabile. Îmbunătăţirea realizărilor elevilor la învăţătură este legată şi condiţionată de climatul optim. „Atmosfera în instituţia educaţională este factorul-cheie care afectează crearea unui mediu ce dezvoltă securitatea personală şi sentimentul de afiliere, valoarea şi respectul reciproc" [12].