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Sample records for ace approach economic

  1. Assessing Cost-Effectiveness in Obesity (ACE-Obesity: an overview of the ACE approach, economic methods and cost results

    Directory of Open Access Journals (Sweden)

    Swinburn Boyd

    2009-11-01

    Full Text Available Abstract Background The aim of the ACE-Obesity study was to determine the economic credentials of interventions which aim to prevent unhealthy weight gain in children and adolescents. We have reported elsewhere on the modelled effectiveness of 13 obesity prevention interventions in children. In this paper, we report on the cost results and associated methods together with the innovative approach to priority setting that underpins the ACE-Obesity study. Methods The Assessing Cost Effectiveness (ACE approach combines technical rigour with 'due process' to facilitate evidence-based policy analysis. Technical rigour was achieved through use of standardised evaluation methods, a research team that assembles best available evidence and extensive uncertainty analysis. Cost estimates were based on pathway analysis, with resource usage estimated for the interventions and their 'current practice' comparator, as well as associated cost offsets. Due process was achieved through involvement of stakeholders, consensus decisions informed by briefing papers and 2nd stage filter analysis that captures broader factors that influence policy judgements in addition to cost-effectiveness results. The 2nd stage filters agreed by stakeholders were 'equity', 'strength of the evidence', 'feasibility of implementation', 'acceptability to stakeholders', 'sustainability' and 'potential for side-effects'. Results The intervention costs varied considerably, both in absolute terms (from cost saving [6 interventions] to in excess of AUD50m per annum and when expressed as a 'cost per child' estimate (from Conclusion The use of consistent methods enables valid comparison of potential intervention costs and cost-offsets for each of the interventions. ACE-Obesity informs policy-makers about cost-effectiveness, health impact, affordability and 2nd stage filters for important options for preventing unhealthy weight gain in children. In related articles cost-effectiveness results and

  2. Economic Hardship in Childhood: A Neglected Issue in ACE Studies?

    Science.gov (United States)

    Braveman, Paula; Heck, Katherine; Egerter, Susan; Rinki, Christine; Marchi, Kristen; Curtis, Mike

    2018-03-01

    Objectives Adverse childhood experiences (ACEs) have been linked with ill-health in adulthood, but ACE literature has focused on family disruption or dysfunction (e.g., child abuse, parental separation), with less attention to economic adversity. We examined whether a mother's economic hardship in childhood (EHC) was associated with women's hardships and health-risk behaviors during/just before pregnancy. Methods We analyzed population-based survey data on 27,102 postpartum California women. EHC included respondents' reports that during childhood they/their families experienced hunger because of inability to afford food or moved because of problems paying rent/mortgage and the frequency of difficulty paying for basic needs. We examined six maternal hardships/behaviors during/just before pregnancy, including four hardships (poverty, food insecurity, homelessness/no regular place to sleep, intimate partner violence) and two behaviors (smoking, binge drinking). Prevalence ratios (PRs) were calculated from sequential logistic regression models estimating associations between EHC (categorized by level of hardship) and each maternal hardship/behavior, first without adjustment, then adjusting for other childhood and current maternal factors, and finally adding family disruption/dysfunction. Results Before adjustment for family disruption/dysfunction, the highest and intermediate EHC levels were associated with each maternal hardship/behavior; after full adjustment, those associations persisted except with smoking. Higher EHC levels generally appeared associated with larger PRs, although confidence intervals overlapped. Conclusions for Policy/Practice These findings link childhood economic hardship with women's hardships, binge drinking, and possibly smoking around the time of pregnancy. Without establishing causality, they support previous research indicating that childhood economic adversity should be considered an ACE.

  3. Economic evaluation of the annual cycle energy system (ACES). Final report. Volume III, appendices

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This volume consists of seven appendices related to ACES, the first three of which are concerned with computer programs. The appendices are entitled: (A) ACESIM: Residential Program Listing; (B) Typical Inputs and Outputs of ACESIM; (C) CACESS: Commercial Building Program Listing; (D) Typical Weather-Year Selection Requirements; (E) Building Characteristics; (F) List of Major Variables Used in the Computer Programs; and (G) Bibliography. 79 references.

  4. An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens

    Directory of Open Access Journals (Sweden)

    Karl A Hassan

    2015-04-01

    Full Text Available The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable. Multidrug efflux pumps are well known mediators of bacterial drug resistance. Genome sequencing efforts have highlighted an abundance of putative efflux pump genes in bacteria. However, it is not clear how many of these pumps play a role in antimicrobial resistance. Several studies have demonstrated that efflux pump genes that participate in drug resistance are typically under tight regulatory control and expressed only in response to their substrates. Consequently, changes in gene expression following antimicrobial shock treatments may be used to identify efflux pumps that mediate antimicrobial resistance, informing targeted functional analyses of these proteins. Using this approach we have characterised novel efflux pumps in both Gram-negative and Gram-positive bacteria. Notably, we recently applied this strategy to characterise the AceI efflux pump from Acinetobacter. AceI is a prototype for a new family of multidrug efflux proteins that is conserved across many proteobacterial lineages. Different efflux pumps in this family have been shown to confer resistance to biocides including chlorhexidine, dequalinium, benzalkonium, proflavine and/or acriflavine. The discovery of this novel family of multidrug efflux proteins raises the possibility that additional undiscovered intrinsic resistance proteins may be encoded in the core genomes of pathogenic bacteria.

  5. Ecological Economics: Themes, Approaches, and Differences with Environmental Economics

    OpenAIRE

    Jeroen C.J.M. van den Bergh

    2000-01-01

    This provides a short overview of the main themes of ecological economics (EE). It isargued that EE provides a platform that fosters multidisciplinary environmental research bybringing together the core contributing disciplines economics and ecology. In addition, EE isregarded as a pluralistic approach to environmental research that can be set opposite to, and hasindeed developed as a response to, traditional environmental and resource economics. Acomparison of the two fields is presented to ...

  6. Social surplus approach and heterodox economics

    OpenAIRE

    Lee, Frederic; Jo, Tae-Hee

    2010-01-01

    Given the emphasis on social provisioning in heterodox economics, two of its central theoretical organizing principles are the concepts of the total social product and the social surplus. This appears to link heterodox economics to the social surplus approach associated with the classical economists and currently with Sraffian economists. However, heterodox economics connects agency with the social surplus and the social product, which the Sraffians reject as they take the level and composit...

  7. Teaching Business and Economic Journalism: Fresh Approaches

    Science.gov (United States)

    Weber, Joseph

    2016-01-01

    Teachers of business and economic journalism are developing creative approaches to attracting students and educating them in a field many find daunting. To recruit, some avoid using the terms "business" or "economic" in course titles, preferring "financial basics" and "financial literacy." Many use novel…

  8. Economic approaches to greenhouse warming

    International Nuclear Information System (INIS)

    Nordhaus, W.D.

    1991-01-01

    Global environmental problems raise a host of major policy questions. They are all scientifically complex and controversial, and no scientific consensus is likely to emerge until irreversible decisions have been made. The costs and benefits of these changes transcend national boundaries, and nations, which cannot appropriate the global costs and benefits of such changes, are unlikely to be able or willing to make efficient decisions on how to combat these global externalities. In addition, these concerns sometimes have impacts over hundreds of years and thereby strain political decision making, which often functions effectively only when the crisis is at hand. This chapter considers some of the economic issues involved in deciding how to react to the threat of global warming. The author first reviews the theory and evidence on the greenhouse effect. He then presents evidence on the impacts of greenhouse warming, the costs of stabilizing climate, and the kinds of adaptations that might be available. In the final section, he reviews the policy initiatives that nations might follow in the near term

  9. MEZZO ECONOMICS ANALITYCAL APPROACH AS THE PROPULSIVE PART OF MANAGERIAL ECONOMICS IN TOURISM

    OpenAIRE

    Kozuharov, Saso

    2011-01-01

    Mezzo Economics covers the area between the Micro and Macro Economics and the organizational approach of the economics of the integral economic communities, which are made of microeconomic entities. Mezzo Economics represents an organizational loop between the Macro economic system and Micro Economics. Tourism industry is a typical represent of Mezzo Economics. Mezzo Economics Analytical Approach represents a compositional and methodological approach that make constitution of the basic and de...

  10. Approaches towards airport economic performance measurement

    Directory of Open Access Journals (Sweden)

    Ivana STRYČEKOVÁ

    2011-01-01

    Full Text Available The paper aims to assess how economic benchmarking is being used by airports as a means of performance measurement and comparison of major international airports in the world. The study focuses on current benchmarking practices and methods by taking into account different factors according to which it is efficient to benchmark airports performance. As methods are considered mainly data envelopment analysis and stochastic frontier analysis. Apart from them other approaches are discussed by airports to provide economic benchmarking. The main objective of this article is to evaluate the efficiency of the airports and answer some undetermined questions involving economic benchmarking of the airports.

  11. Economic Systems: A Modular Approach. Cultural Anthropology.

    Science.gov (United States)

    Kassebaum, Peter

    Designed for use as supplementary instructional material in a cultural anthropology course, this learning module uses a systems approach to allow students to see the connections and similarities which most cultural groups share on the basis of the type of economic organization that they exhibit. The module begins with a general discussion of…

  12. Preface ACE 2013

    NARCIS (Netherlands)

    Katayose, Haruhiro; Reidsma, Dennis; Katayose, Haruhiro; Nijholt, Antinus

    2013-01-01

    These are the proceedings of the 10th International Conference on Advances in Computer Entertainment (ACE 2013), hosted by the Human Media Interaction research group of the Centre for Telematics and Information Technology at the University of Twente, The Netherlands. The ACE series of conferences,

  13. Institutional economics and economic organisation theory: An integrated approach

    NARCIS (Netherlands)

    Slangen, L.H.G.; Loucks, L.A.; Slangen, A.H.L.

    2008-01-01

    This publication presents one of the first attempts to integrate two emerging bodies of economic research: institutional economics and organizational theory. It begins within the framework of neoclassical economics, and then extends the boundaries of this framework to offer answers to questions that

  14. Institutional economics and economic organisation theory : an integrated approach

    NARCIS (Netherlands)

    Slangen, L.H.G.; Loucks, L.; Slangen, A.H.L.

    2008-01-01

    This publication presents one of the first attempts to integrate two emerging bodies of economic research: institutional economics and organizational theory. It begins within the framework of neoclassical economics, and then extends the boundaries of this framework to offer answers to questions that

  15. Sustainable Groundwater Management Using Economic Incentive Approach

    Science.gov (United States)

    Yan, T.; Shih, J.; Sanchirico, J. N.

    2006-12-01

    Although groundwater accounts for about 20% of the water consumption in the US, recent urban development, land use changes and agricultural activities in many regions (for example, Chesapeake Bay and eastern shore of Maryland) have resulted in deleterious impacts on groundwater quality. These impacts have dramatically increased potential human health and ecological system risks. One example is nitrogen pollution delivered to local waterways from septic systems via groundwater. Conventional approaches for nitrogen removal, such as pumping and treatment (nitrification-denitrification) process, tend to be expensive. On the other hand, economic incentive approaches (such as marketable permits) have the potential to increase the efficiency of environmental policy by reducing compliance costs for regulated entities and individuals and/or achieving otherwise uneconomical pollution reduction. The success of the sulfur dioxide trading market has led to the creation of trading markets for other pollutants, especially at the regional, state, and smaller (e.g. watershed) scales. In this paper, we develop an integrated framework, which includes a groundwater flow and transport model, and a conceptual management model. We apply this framework to a synthetic set up which includes one farm and two development areas in order to investigate the potential of using economic incentive approaches for groundwater quality management. The policy analysis is carried out by setting up the objective of the modeling framework to minimize the total cost of achieving groundwater quality goals at specific observation point using either a transferable development right (TDR) system between development areas and/or using a tax for fertilizer usage in the farm area. The TDR system consists of a planning agency delineating a region into restricted-use (e.g., agriculture, open space) and high intensity zones (e.g., residential, commercial uses). The agency then endows landowners in the restricted area

  16. Decision Making under Ecological Regime Shift: An Experimental Economic Approach

    OpenAIRE

    Kawata, Yukichika

    2011-01-01

    Environmental economics postulates the assumption of homo economicus and presumes that externality occurs as a result of the rational economic activities of economic agents. This paper examines this assumption using an experimental economic approach in the context of regime shift, which has been receiving increasing attention. We observe that when externality does not exist, economic agents (subjects of experimemt) act economically rationally, but when externality exists, economic agents avoi...

  17. Agile Coalition Environment (ACE)

    National Research Council Canada - National Science Library

    McGuire, Michele; Daniel, Dale

    2004-01-01

    .... Interoperability is achieved across all applications, platforms, and security domains. ACE is presented as a network capability that can be applied to the Coalition Enterprise Information Exchange System (CENTRIXS...

  18. ACE blood test

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003567.htm ACE blood test To use the sharing features on this page, ... Alternative Names Serum angiotensin-converting enzyme; SACE Images Blood test References Carty RP, Pincus MR, Sarafraz-Yazdi E. ...

  19. The ACE experiment

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    The Antiproton Cell Experiment (ACE) as shown by Michael Holzscheiter (spokesperson), Niels Bassler (co-spokesperson) and Helge Knudsen. ACE is located on the Antiproton Decelerator (AD) at CERN. An antiproton annihilates a proton in the nucleus of a cancer cell, producing a pair of gamma rays, destroying the entire cell and some surrounding cells. Many fewer antiprotons are required in this treatment than in the equivalent proton hadron therapy, so there is less risk of healthy tissue damage.

  20. ACE phenotyping in Gaucher disease.

    Science.gov (United States)

    Danilov, Sergei M; Tikhomirova, Victoria E; Metzger, Roman; Naperova, Irina A; Bukina, Tatiana M; Goker-Alpan, Ozlem; Tayebi, Nahid; Gayfullin, Nurshat M; Schwartz, David E; Samokhodskaya, Larisa M; Kost, Olga A; Sidransky, Ellen

    2018-04-01

    Gaucher disease is characterized by the activation of splenic and hepatic macrophages, accompanied by dramatically increased levels of angiotensin-converting enzyme (ACE). To evaluate the source of the elevated blood ACE, we performed complete ACE phenotyping using blood, spleen and liver samples from patients with Gaucher disease and controls. ACE phenotyping included 1) immunohistochemical staining for ACE; 2) measuring ACE activity with two substrates (HHL and ZPHL); 3) calculating the ratio of the rates of substrate hydrolysis (ZPHL/HHL ratio); 4) assessing the conformational fingerprint of ACE by evaluating the pattern of binding of monoclonal antibodies to 16 different ACE epitopes. We show that in patients with Gaucher disease, the dramatically increased levels of ACE originate from activated splenic and/or hepatic macrophages (Gaucher cells), and that both its conformational fingerprint and kinetic characteristics (ZPHL/HHL ratio) differ from controls and from patients with sarcoid granulomas. Furthermore, normal spleen was found to produce high levels of endogenous ACE inhibitors and a novel, tightly-bound 10-30 kDa ACE effector which is deficient in Gaucher spleen. The conformation of ACE is tissue-specific. In Gaucher disease, ACE produced by activated splenic macrophages differs from that in hepatic macrophages, as well as from macrophages and dendritic cells in sarcoid granulomas. The observed differences are likely due to altered ACE glycosylation or sialylation in these diseased organs. The conformational differences in ACE may serve as a specific biomarker for Gaucher disease. Copyright © 2018 Elsevier Inc. All rights reserved.

  1. Economic Gardening through Entrepreneurship Education: A Service-Learning Approach

    Science.gov (United States)

    Desplaces, David E.; Wergeles, Fred; McGuigan, Patrick

    2009-01-01

    This article outlines the implementation of a service-learning approach in an entrepreneurship programme using an "economic gardening" strategy. Economic Gardening through Service-Learning (EGS-L) is an approach to economic development that helps local businesses and students grow through a facilitated learning process. Learning is made possible…

  2. Feminist Development Economics : An Institutional Approach to Household Analysis

    NARCIS (Netherlands)

    I.P. van Staveren (Irene); O. Odebode (Olasunbo)

    2014-01-01

    markdownabstract__Abstract__ In this chapter, we argue that an institutional approach to feminist development economics provides deeper understandings to how gender inequalities function in economic processes in developing countries. We do this in three ways. First, we distinguish between

  3. ACES CONTINUOUS DATA V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was based at the Naval Air Facility Key West in Florida. During August, 2002, ACES researchers conducted overflights of...

  4. ACES TRIGGERED DATA V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was based at the Naval Air Facility Key West in Florida. During August 2002, ACES researchers conducted overflights of...

  5. ACES TIMING DATA V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was based at the Naval Air Facility Key West in Florida. During August or 2002, ACES researchers overflights of...

  6. ACES CONTINUOUS DATA V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was Based at the Naval Air Facility Key West in Florida. ACES researchers in August 2002 conducted overflights of...

  7. ACES TRIGGERED DATA V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was Based at the Naval Air Facility Key West in Florida. ACES researchers in August 2002 conducted overflights of...

  8. ACES LOG DATA V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was Based at the Naval Air Facility Key West in Florida. ACES researchers in August 2002 conducted overflights of...

  9. ACES TIMING DATA V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was Based at the Naval Air Facility Key West in Florida. ACES researchers in August 2002 conducted overflights of...

  10. Angiotensin converting enzyme (ACE and ACE2 bind integrins and ACE2 regulates integrin signalling.

    Directory of Open Access Journals (Sweden)

    Nicola E Clarke

    Full Text Available The angiotensin converting enzymes (ACEs are the key catalytic components of the renin-angiotensin system, mediating precise regulation of blood pressure by counterbalancing the effects of each other. Inhibition of ACE has been shown to improve pathology in cardiovascular disease, whilst ACE2 is cardioprotective in the failing heart. However, the mechanisms by which ACE2 mediates its cardioprotective functions have yet to be fully elucidated. Here we demonstrate that both ACE and ACE2 bind integrin subunits, in an RGD-independent manner, and that they can act as cell adhesion substrates. We show that cellular expression of ACE2 enhanced cell adhesion. Furthermore, we present evidence that soluble ACE2 (sACE2 is capable of suppressing integrin signalling mediated by FAK. In addition, sACE2 increases the expression of Akt, thereby lowering the proportion of the signalling molecule phosphorylated Akt. These results suggest that ACE2 plays a role in cell-cell interactions, possibly acting to fine-tune integrin signalling. Hence the expression and cleavage of ACE2 at the plasma membrane may influence cell-extracellular matrix interactions and the signalling that mediates cell survival and proliferation. As such, ectodomain shedding of ACE2 may play a role in the process of pathological cardiac remodelling.

  11. Economic Institutions and Stability : A Network Approach

    NARCIS (Netherlands)

    Gilles, R.P.; Lazarova, E.A.; Ruys, P.H.M.

    2011-01-01

    We consider a network economy in which economic agents are connected within a structure of value-generating relationships. Agents are assumed to be able to participate in three types of economic activities: autarkic self-provision; binary matching interactions; and multi-person cooperative

  12. BEHAVIORAL INPUTS TO THE THEORETICAL APPROACH OF THE ECONOMIC CRISIS

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    Sinziana BALTATESCU

    2015-09-01

    Full Text Available The current economic and financial crisis gave room for the theoretical debates to reemerge. The economic reality challenged the mainstream neoclassical approach leaving the opportunity for the Austrian School, Post Keynesianism or Institutionalists to bring in front theories that seem to better explain the economic crisis and thus, leaving space for more efficient economic policies to result. In this context, the main assumptions of the mainstream theoretical approach are challenged and reevaluated, behavioral economics is one of the main challengers. Without developing in an integrated school of thought yet, behavioral economics brings new elements within the framework of economic thinking. How are the main theoretical approaches integrating these new elements and whether this process is going to narrow the theory or enrich it to be more comprehensive are questions to which this paper tries to answer, or, at least, to leave room for an answer.

  13. ECONOMIC SECURITY – NEW APPROACHES IN THE CONTEXT OF GLOBALIZATION

    Directory of Open Access Journals (Sweden)

    Gabriel ANDRUSEAC

    2015-08-01

    Full Text Available Nowadays, more than ever, economic relations between states are the ones that define the general character of the relations between them and establish economic security as a concept which cannot be neglected anymore. Globalization, the process that shapes the international environment, undermines the old definition of economic security and forces its redefinition. The article aims to identify and analyse the effects of globalization on economic security and the new approaches it takes in this context.

  14. Spatial Economics: The Evolution of Approaches and Methodology

    Directory of Open Access Journals (Sweden)

    Minakir P. A.

    2010-06-01

    Full Text Available The evolution of theoretical principles and approaches to the study of spatial organization of the economy is set forth. The changes in the content of the category «economic region» are analyzed. A comparative assessment is given of theoretical approaches to studying spatial aspects of the economy. The limited character of theoretical and applied regional economic tools in studying spatial organization and spatial interactions between economic agents of the modern economy is shown

  15. A Hybrid Approach to Teaching Managerial Economics

    Science.gov (United States)

    Metzgar, Matthew

    2014-01-01

    Many institutions in higher education are experimenting with hybrid teaching approaches to undergraduate courses. Online resources may provide a number of advantages to students as compared to in-class approaches. Research regarding the effectiveness of hybrid approaches is mixed and still accumulating. This paper discusses the use of a hybrid…

  16. Conoco serves an ACE

    Energy Technology Data Exchange (ETDEWEB)

    Cottrill, A.; Jackson, G. [Arup Energy (United Kingdom)

    2001-06-01

    The Hang Tuah gas platform recently installed in Conoco's West Natuna field off Indonesia is the first example in the world of a low-cost, relocatable platform based on the ACE concept developed by Arup Energy in the UK. It is expected to operate at two other locations in the West Natuna block during its 25-year lifetime. The ACE platform, which can operate at depths up to 100 m, has four main components: the deck in the form of a barge, strand jacks to lower the four lattice legs on a rectangular steel gravity base, and a jacking system. The background to the decision to opt for the ACE concept, its advantages, the delivery contract, the platform's flexibility, and its fabrication and installation are described. The weights of the various components and the levels to which loads can be raised are summarised in a table. The areas where cost savings are made with this design are explained in a side box.

  17. Access to justice : An economic approach

    NARCIS (Netherlands)

    Zhou, J.

    2010-01-01

    This Ph.D. thesis consists of a collection of four independent papers on economic analysis of access to justice. The research methodologies involve game theoretical and empirical analysis of litigation and settlement. Chapter two investigates the institutional causes of delay in litigation. Using

  18. New approaches to food safety economics

    NARCIS (Netherlands)

    Velthuis, A.G.J.; Unnevehr, L.J.; Hogeveen, H.; Huirne, R.B.M.

    2002-01-01

    Food-safety economics is a new research field, which needs a solid framework of concepts, procedures and data to support the decision-making process in food-safety improvement. Food safety is a theme that plays at many levels in the community: at the consumer level, at the farm or business level, at

  19. A CONCEPTUAL APPROACH TO ECONOMIC AGGLOMERATIONS

    Directory of Open Access Journals (Sweden)

    Mădălina-Ștefania Dîrzu

    2012-09-01

    Full Text Available Technological progress and rapid structural adjustments have characterized a lot of economies in the last century and they still feature pronounced structures. An important observation is that economic activities tend to agglomerate in space as a result of some kind increasing returns, forming eventually economic agglomerations. When various companies gather together, they establish specific forms of interaction. Increasing returns produce when this mutual interplay creates positive externalities for those firms which operate into an agglomeration. In this context, it is crucial to raise a question: what is an economic agglomeration and what do different scientists imply when using the concept? The phenomenon of agglomeration has attracted researchers from various disciplines employing a hybrid set of analytical perspectives. This whole framework is still puzzled with contradictory conceptualizations which are often used in an ambiguous way. Scientists tend to utilize notions such as agglomeration, cluster, territorial network, specialization, concentration somewhat interchangeably and with little concern about how to operationalize them. To shed a light on this issue, the aim of this paper is to provide a comprehensive analyze of different theoretical framework in which economic agglomerations have been debated and researched.

  20. Heterogeneous Computing in Economics: A Simplified Approach

    DEFF Research Database (Denmark)

    Dziubinski, Matt P.; Grassi, Stefano

    This paper shows the potential of heterogeneous computing in solving dynamic equilibrium models in economics. We illustrate the power and simplicity of the C++ Accelerated Massive Parallelism recently introduced by Microsoft. Starting from the same exercise as Aldrich et al. (2011) we document a ...

  1. Assessing sufficient capability: A new approach to economic evaluation.

    Science.gov (United States)

    Mitchell, Paul Mark; Roberts, Tracy E; Barton, Pelham M; Coast, Joanna

    2015-08-01

    Amartya Sen's capability approach has been discussed widely in the health economics discipline. Although measures have been developed to assess capability in economic evaluation, there has been much less attention paid to the decision rules that might be applied alongside. Here, new methods, drawing on the multidimensional poverty and health economics literature, are developed for conducting economic evaluation within the capability approach and focusing on an objective of achieving "sufficient capability". This objective more closely reflects the concern with equity that pervades the capability approach and the method has the advantage of retaining the longitudinal aspect of estimating outcome that is associated with quality-adjusted life years (QALYs), whilst also drawing on notions of shortfall associated with assessments of poverty. Economic evaluation from this perspective is illustrated in an osteoarthritis patient group undergoing joint replacement, with capability wellbeing assessed using ICECAP-O. Recommendations for taking the sufficient capability approach forward are provided. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. An economic approach to 'losses and damages'

    International Nuclear Information System (INIS)

    Roulleau, Thomas

    2015-01-01

    Given ever more greenhouse gas emissions, developing countries have recently placed the issue of 'losses and damages' on the bargaining table. The losses and damages ensuing from climate catastrophes depend on factors that are both planetary (extreme meteorological phenomena wherein climate change is a factor) and domestic (the exposure and vulnerability of populations). The Warsaw International Mechanism for Loss and Damage Associated with Climate Change Impacts was set up in 2013. Several developing countries are demanding that it become autonomous with its own funding. This demand does not seem justified scientifically or economically in the current context. Although economic losses owing to climate-related catastrophes have increased in recent decades, they are, as scientific studies have shown, due to increases in wealth and in the population's exposure and not to climate change as such. Furthermore, the aforementioned funding mechanism risks impeding efficient domestic actions for reducing a country's vulnerability and its population's exposure to climate-related risks

  3. ACE - Manufacturer Identification Code (MID)

    Data.gov (United States)

    Department of Homeland Security — The ACE Manufacturer Identification Code (MID) application is used to track and control identifications codes for manufacturers. A manufacturer is identified on an...

  4. An assessment of uncertainty on a LOFT L2-5 LBLOCA PCT based on the ACE-RSM approach: complementary work for the OECD BEMUSE PHASE-III program

    International Nuclear Information System (INIS)

    Ahn, Kwang Il; Chung, Bub Dong; Lee, John C.

    2010-01-01

    As pointed out in the OECD BEMUSE Program, when a high computation time is taken to obtain the relevant output values of a complex physical model (or code), the number of statistical samples that must be evaluated through it is a critical factor for the sampling-based uncertainty analysis. Two alternative methods have been utilized to avoid the problem associated with the size of these statistical samples: one is based on Wilks' formula, which is based on simple random sampling, and the other is based on the conventional nonlinear regression approach. While both approaches provide a useful means for drawing conclusions on the resultant uncertainty with a limited number of code runs, there are also some unique corresponding limitations. For example, a conclusion based on the Wilks' formula can be highly affected by the sampled values themselves, while the conventional regression approach requires an a priori estimate on the functional forms of a regression model. The main objective of this paper is to assess the feasibility of the ACE-RSM approach as a complementary method to the Wilks' formula and the conventional regression-based uncertainty analysis. This feasibility was assessed through a practical application of the ACE-RSM approach to the LOFT L2-5 LBLOCA PCT uncertainty analysis, which was implemented as a part of the OECD BEMUSE Phase III program

  5. Economic versus technical approaches to frequency management

    DEFF Research Database (Denmark)

    Falch, Morten; Tadayoni, Reza

    2004-01-01

    to demonstrate how regulators could incorporate an econmic dimension into frequency allocation. The paper concludes that a free market approach is still not possible for some parts of the frequency management process; in short term, regulators must therefore continue to prioritize between applications....

  6. Determinants of Executive Directors’ Remuneration in Malaysia’s ACE Market

    OpenAIRE

    Hong, Chee Yoong

    2016-01-01

    This purpose of this study is to analyse and evaluate the determinants of executive directors' remuneration of public listed companies in Malaysia's ACE Market. This study is using panel data analysis on 76 public listed companies in ACE Market from 2009 to 2013 (5 years) with the total of 380 observations. Similar to AIM Market in UK, ACE Market is set up to facilitate emerging companies, which are important to Malaysia economic growth, to raise capital easily. Unfortunately, these companies...

  7. A Discrete Monetary Economic Growth Model with the MIU Approach

    Directory of Open Access Journals (Sweden)

    Wei-Bin Zhang

    2008-01-01

    Full Text Available This paper proposes an alternative approach to economic growth with money. The production side is the same as the Solow model, the Ramsey model, and the Tobin model. But we deal with behavior of consumers differently from the traditional approaches. The model is influenced by the money-in-the-utility (MIU approach in monetary economics. It provides a mechanism of endogenous saving which the Solow model lacks and avoids the assumption of adding up utility over a period of time upon which the Ramsey approach is based.

  8. An Optimization Approach to the Dynamic Allocation of Economic Capital

    NARCIS (Netherlands)

    Laeven, R.J.A.; Goovaerts, M.J.

    2004-01-01

    We propose an optimization approach to allocating economic capital, distinguishing between an allocation or raising principle and a measure for the risk residual. The approach is applied both at the aggregate (conglomerate) level and at the individual (subsidiary) level and yields an integrated

  9. Economic approach of the environment and environmental conservation

    International Nuclear Information System (INIS)

    Verbruggen, A.

    2008-01-01

    This book takes the non-economist by the hand in a step-by-step economic approach of environmental issues and how to handle them. Two chapters provide an introduction to the concepts of the economy, chapter six in decision theory. In the first chapter, the economist discovers a broader vision by testing the economic approach to insights from other disciplines. Chapter 4 explains how economic reasoning can contribute tot environmental protection in practice. The consideration of the costs and benefits of environmental protection indicates objectives that must be pursued for the community. The conflict between private and public interest forces policy makers to get and maintain the numerous polluters focused on environmental protection. Suitable instruments are discussed in chapter five, including criteria for choice and an in-depth study of the economic instruments levies and tradable emission permits. The EU Emission trading Scheme is used as reference. [mk] [nl

  10. Analysis of Increasing Malwares and Cyber Crimes Using Economic Approach

    OpenAIRE

    Asgher, Umer; Dar, Fahad Moazzam; Hamza, Ali; Paracha, Abdul Moeed

    2014-01-01

    The economics of an internet crime has newly developed into a field of controlling black money. This economic approach not only provides estimated technique of analyzing internet crimes but also gives details to analyzers of system dependability and divergence. This paper will highlight on the subject of online crime, which has formed its industry since. It all started from amateur hackers who cracked websites and wrote malicious software in pursuit of fun or achieving limited objectives to p...

  11. Beginning RPG Maker VX Ace

    CERN Document Server

    Perez, Darrin

    2014-01-01

    Beginning RPG Maker VX Ace takes you through the process of using the RPG Maker VX Ace game development engine to create your very own role playing game. The book has been designed with the complete beginner in mind who has little to no experience with the engine. Tutorials and exercises will take you from installing the software to putting the final touches upon your first project. Game design can be quite a daunting challenge, as it generally involves a large amount of programming know-how on top of having to plan everything out that makes a good game what it is. RPG Maker VX Ace

  12. DAF: differential ACE filtering image quality assessment by automatic color equalization

    Science.gov (United States)

    Ouni, S.; Chambah, M.; Saint-Jean, C.; Rizzi, A.

    2008-01-01

    Ideally, a quality assessment system would perceive and measure image or video impairments just like a human being. But in reality, objective quality metrics do not necessarily correlate well with perceived quality [1]. Plus, some measures assume that there exists a reference in the form of an "original" to compare to, which prevents their usage in digital restoration field, where often there is no reference to compare to. That is why subjective evaluation is the most used and most efficient approach up to now. But subjective assessment is expensive, time consuming and does not respond, hence, to the economic requirements [2,3]. Thus, reliable automatic methods for visual quality assessment are needed in the field of digital film restoration. The ACE method, for Automatic Color Equalization [4,6], is an algorithm for digital images unsupervised enhancement. It is based on a new computational approach that tries to model the perceptual response of our vision system merging the Gray World and White Patch equalization mechanisms in a global and local way. Like our vision system ACE is able to adapt to widely varying lighting conditions, and to extract visual information from the environment efficaciously. Moreover ACE can be run in an unsupervised manner. Hence it is very useful as a digital film restoration tool since no a priori information is available. In this paper we deepen the investigation of using the ACE algorithm as a basis for a reference free image quality evaluation. This new metric called DAF for Differential ACE Filtering [7] is an objective quality measure that can be used in several image restoration and image quality assessment systems. In this paper, we compare on different image databases, the results obtained with DAF and with some subjective image quality assessments (Mean Opinion Score MOS as measure of perceived image quality). We study also the correlation between objective measure and MOS. In our experiments, we have used for the first image

  13. [ACE inhibitors and the kidney].

    Science.gov (United States)

    Hörl, W H

    1996-01-01

    Treatment with ACE inhibitors results in kidney protection due to reduction of systemic blood pressure, intraglomerular pressure, an antiproliferative effect, reduction of proteinuria and a lipid-lowering effect in proteinuric patients (secondary due to reduction of protein excretion). Elderly patients with diabetes melitus, coronary heart disease or peripheral vascular occlusion are at risk for deterioration of kidney function due to a high frequency of renal artery stenosis in these patients. In patients with renal insufficiency dose reduction of ACE inhibitors is necessary (exception: fosinopril) but more important is the risk for development of hyperkalemia. Patients at risk for renal artery stenosis and patients pretreated with diuretics should receive a low ACE inhibitor dosage initially ("start low - go slow"). For compliance reasons once daily ACE inhibitor dosage is recommended.

  14. Advanced Center for Engineering (ACE)

    Data.gov (United States)

    Federal Laboratory Consortium — Cave Automatic Virtual Environment (CAVE™)The ACE Team provides the ability to conduct fullscale interactive virtual CAD reviews using the CAVE.CapabilitiesTARDEC's...

  15. Integrated approach to economical, reliable, safe nuclear power production

    International Nuclear Information System (INIS)

    1982-06-01

    An Integrated Approach to Economical, Reliable, Safe Nuclear Power Production is the latest evolution of a concept which originated with the Defense-in-Depth philosophy of the nuclear industry. As Defense-in-Depth provided a framework for viewing physical barriers and equipment redundancy, the Integrated Approach gives a framework for viewing nuclear power production in terms of functions and institutions. In the Integrated Approach, four plant Goals are defined (Normal Operation, Core and Plant Protection, Containment Integrity and Emergency Preparedness) with the attendant Functional and Institutional Classifications that support them. The Integrated Approach provides a systematic perspective that combines the economic objective of reliable power production with the safety objective of consistent, controlled plant operation

  16. Identity and individual economic agents: a narrative approach

    NARCIS (Netherlands)

    Davis, J.B.; White, M.D.; van Staveren, I.

    2010-01-01

    This paper offers an account of how individuals act as agents when we employ a narrative approach to explaining their personal identities. It applies Korsgaard's idea of a "reflective structure of consciousness" to provide foundations for a richer account of the individual economic agent, and uses

  17. Identity and individual economic agents: a narrative approach

    NARCIS (Netherlands)

    Davis, J.B.

    2009-01-01

    This paper offers an account of how individuals act as agents when we employ a narrative approach to explaining their personal identities. It applies Korsgaard's idea of a "reflective structure of consciousness" to provide foundations for a richer account of the individual economic agent, and uses

  18. Approaches to Economic Empowerment of Rural Women for Climate ...

    African Journals Online (AJOL)

    There are several ways of promoting women's economic participation while also counteracting climate change. One approach in the field of climate mitigation is the promotion of renewable energies that help avoid greenhouse gas emissions. The potential of rural women as agents of change for climate mitigation and ...

  19. A Dooyeweerd-based approach to regional economic development

    NARCIS (Netherlands)

    Aay, H; Van Langevelde, A

    2005-01-01

    Within regional science there is a need for a general theory of regional economic development, one that evaluates and integrates existing approaches. In this paper, the philosophy of Herman Dooyeweerd is used as a basis for conceptualising the contours of such a theory. Contributions of this

  20. Regulating the Relationship between State and Religion: An Economic Approach

    NARCIS (Netherlands)

    A.M.I.B. Vandenberghe (Ann-Sophie)

    2012-01-01

    markdownabstract__Abstract__ In defining its relationship towards religion, the Dutch government is committed to the values of freedom of religion and neutrality. This article uses the economic approach to freedom of religion and state neutrality as a tool for looking at the existing Dutch policy

  1. Space Weather Drivers in the ACE Era

    Science.gov (United States)

    Vogt, M.; Puhl-Quinn, P.; Jordanova, V. K.; Smith, C. W.; Cohen, C. M.

    2004-12-01

    The Advanced Composition Explorer (ACE) spacecraft was launched Aug.~25, 1997 [Stone et al., 1998]. Beginning shortly after launch and continuing to the present day ACE has provided real-time data telemetry of solar wind conditions upstream of the Earth. The real-time data includes solar wind speed and density, magnetic field direction and magnitude, and a range of energetic particle intensities [Zwickl et al., 1999]. The real-time data product is provided within 5 minutes of observation and many partners from both industry and science use these data for a variety of purposes. The most common purpose of practical industrial application involves mitigation of lost services arising from magnetospheric storm activity. Many space weather efforts are directed at providing improved predictions of magnetospheric response that can be applied to real-time data in the hope of better predicting the vulnerability and required action of industry to approaching disturbances. It therefore seems prudent that following 6 years of activity including one solar maximum period we should evaluate the nature and strength of the largest disturbances observed with the hope of better assessing the industrial response. Simply put: ``Did ACE observe disturbances that were as large as those seen previously during the space age?'' If not, it may be the case that industry must evaluate its response to the real-time warnings and not become complacent by the simple act of survival. We compare the most intense space weather events of the ACE era with those recorded on the Omnitape data set spanning 40+ years of spacecraft measurements in the near-Earth environment. We compare both magnetospheric response parameters and solar wind drivers. In addition, we compare the large energetic particle events over the same time frame. Stone, E.~C., et al., Space Science Rev., 86(1-4), 357-408, 1998. Zwickl, R.~D., et al., Space Science Rev., 86(1-4), 633-648, 1998.

  2. Economic evaluation of I and C modernization approach in NPPs

    International Nuclear Information System (INIS)

    Kang, Hyeon Tae; Sung, Chan Ho; Lee, Jae Ki

    2009-01-01

    Utilities have recently been debating the respective pros and cons of implementation of a multi-phase modernization during several normal outages versus a single major modernization implementation during a prolonged outage. We have studied these approaches and have been developing the basic design of NPPs I and C modernization since early 2008. As part of this study, analyses of the NPPs I and C systems were conducted and the need for upgrading the systems was raised. One of the primary concerns regarding the system modernization is a cost-benefit implementation, which will influence the modernization approach. From this viewpoint, the I and C modernization must consider economic factors such as I and C vendor cost, architecture engineering cost, installation cost, utility cost, and other transition costs such as training and procedure development. This paper presents a comparison study of economical aspects including cost evaluation between the aforementioned modernization implementations and suggests a solution for the I and C modernization approach. (author)

  3. Trajectories of Work Disability and Economic Insecurity Approaching Retirement.

    Science.gov (United States)

    Shuey, Kim M; Willson, Andrea E

    2017-07-08

    In this article, we examine the connection between trajectories of work disability and economic precarity in late midlife. We conceptualize work disability as a possible mechanism linking early and later life economic disadvantage. We model trajectories of work disability characterized by timing and stability for a cohort of Baby Boomers (22-32 in 1981) using 32 years of data from the Panel Study of Income Dynamics and latent class analysis. Measures of childhood disadvantage are included as predictors of work disability trajectories, which are subsequently included in logistic regression models predicting four economic outcomes (poverty, asset poverty, home ownership, and pension ownership) at ages 54-64. Childhood disadvantage selected individuals into five distinct classes of work disability that differed in timing and stability. All of the disability trajectories were associated with an increased risk of economic insecurity in late midlife compared to the never work disabled. This study contributes to the aging literature through its incorporation of the early life origins of pathways of disability and their links to economic outcomes approaching retirement. Findings suggest work disability is anchored in early life disadvantage and is associated with economic insecurity later in life. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. The Economic Security of Bank: Theoretical Basis and Systemic Approach

    Directory of Open Access Journals (Sweden)

    Gavlovska Nataliia I.

    2017-07-01

    Full Text Available The article analyzes the existing approaches to interpreting the category of «economic security of bank». A author’s own definition of the concept of «economic security of bank» has been proposed, which should be understood as condition of protecting the vital interests of bank, achieved by harmonizing relationships with the entities of external influence and optimizing the internal system processes, thus enabling efficient function as well as development by means of an adaptation mechanism. A number of approaches to understanding the substance of the above concept has been allocated and their main characteristics have been provided. The need to study the specifics of interaction of banking institutions with the external environment in the context of interaction between the State agents and market actors has been underlined. Features of formation of the term of «system» have been defined, three main groups of approaches to interpretation of the term have been provided. A author’s own definition of the concept of «economic security system of bank» has been proposed. A concrete definition of principles for building an economic security system of bank has been provided.

  5. The personnel economics approach to public workforce research.

    Science.gov (United States)

    Gibbs, Michael

    2009-11-01

    This article argues that the relatively new field of personnel economics (PE) holds strong potential as a tool for studying public sector workforces. This subfield of labor economics is based on a strong foundation of microeconomics, which provides a robust theoretical foundation for studying workforce and organizational design issues. PE has evolved on this foundation to a strong practical emphasis, with theoretical insights designed for practical use and with strong focus on empirical research. The field is also characterized by creative data entrepreneurship. The types of datasets that personnel economists use are described. If similar datasets can be obtained for public sector workforces, PE should be a very useful approach for studying them.

  6. STATE AND ECONOMY IN BOURGEOISIES ECONOMIC THEORIES: A CRITICAL APPROACH

    Directory of Open Access Journals (Sweden)

    Verena Hernández-Pérez

    2016-01-01

    Full Text Available The issue of state-economy relationship has been present throughout the history of bourgeois economic thought. In the bourgeois liberal tradition the distinction between civil society and state has been presented as total and necessary, reserving to the first one the monopoly of economic activity, based on the principle of self-regulating market. From Keynes bourgeois economists were divided into two sides, one side those who still deny the state capacity to intervene right in the economy, and the other those who recognize the need for their participation. This paper proposes a critical approach to the major bourgeois theoretical positions on the relationship state-economy. 

  7. Economic evaluation of multilateral nuclear fuel cycle approach

    International Nuclear Information System (INIS)

    Takashima, Ryuta; Kuno, Yusuke; Omoto, Akira; Tanaka, Satoru

    2011-01-01

    Recently previous works have shown that multilateral nuclear fuel cycle approach has benefits not only of non-proliferation but also of cost effectiveness. This is because for most facilities in nuclear fuel cycle, there exist economies of scale, which has a significant impact on the costs of nuclear fuel cycle. Therefore, the evaluation of economic rationality is required as one of the evaluation factors for the multilateral nuclear fuel cycle approach. In this study, we consider some options with respect to multilateral approaches to nuclear fuel cycle in Asian-Pacific region countries that are proposed by the University of Tokyo. In particular, the following factors are embedded into each type: A) no involvement of assurance of services, B) provision of assurance of services including construction of new facility, without transfer of ownership, and C) provision of assurance of service including construction of new joint facilities with ownership transfer of facilities to multilateral nuclear fuel cycle approach. We show the overnight costs taking into account install and operation of nuclear fuel cycle facilities for each option. The economic parameter values such as uranium price, scale factor, and market output expansion influences the total cost for each option. Thus, we show how these parameter values and economic risks affect the total overnight costs for each option. Additionally, the international facilities could increase the risk of transportation for nuclear material compared to national facilities. We discuss the potential effects of this transportation risk on the costs for each option. (author)

  8. Historic, economic and geographic approach to the relations between economic growth and oil prices

    International Nuclear Information System (INIS)

    Girard, C.

    1992-01-01

    This paper attempts to analyze the complex relations between energy prices and economic growth. In part 1, the history of the last 30 years is used to analyze the consequences of energy price variations on world economic growth. In part 2, two interpretation schemes are described successively. One has to do with the international oil market, and the other concerns the impact of oil shocks on national economies. In part 3, an approach by type of country leads to conclusions respectively for the industrialized countries, for the developing countries and for the newly industrialized countries. 1 fig

  9. An object-oriented approach to energy-economic modeling

    Energy Technology Data Exchange (ETDEWEB)

    Wise, M.A.; Fox, J.A.; Sands, R.D.

    1993-12-01

    In this paper, the authors discuss the experiences in creating an object-oriented economic model of the U.S. energy and agriculture markets. After a discussion of some central concepts, they provide an overview of the model, focusing on the methodology of designing an object-oriented class hierarchy specification based on standard microeconomic production functions. The evolution of the model from the class definition stage to programming it in C++, a standard object-oriented programming language, will be detailed. The authors then discuss the main differences between writing the object-oriented program versus a procedure-oriented program of the same model. Finally, they conclude with a discussion of the advantages and limitations of the object-oriented approach based on the experience in building energy-economic models with procedure-oriented approaches and languages.

  10. Understanding Antegrade Colonic Enema (ACE) Surgery

    Science.gov (United States)

    ... Enema (ACE) Surgery Menu Overview Procedure Details Risks / Benefits What is antegrade colonic enema (ACE) surgery? Antegrade ... Accepted Insurance Make a Donation Refer a Patient Phone Directory Blog, News & Mobile Apps Consult QD Health Essentials Newsroom Mobile Apps ...

  11. ACES ELECTRIC FIELD MILL V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The ALTUS Cloud Electrification Study (ACES) was based at the Naval Air Facility Key West in Florida. ACES researchers in August 2002 conducted overflights of...

  12. Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

    NARCIS (Netherlands)

    Schelleman, H; Klungel, O H; van Duijn, C M; Witteman, J C M; Hofman, A; de Boer, A; Stricker, B H Ch

    AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug. METHODS: This was a cohort study among 239 subjects who started ACE

  13. Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE

    OpenAIRE

    Rella, Monika; Elliot, Joann L; Revett, Timothy J; Lanfear, Jerry; Phelan, Anne; Jackson, Richard M; Turner, Anthony J; Hooper, Nigel M

    2007-01-01

    Abstract Background Mammalian angiotensin converting enzyme (ACE) plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2, has been identified in mammals. Results Here we report the identification and characterisation of the gene encoding a third homologue of ACE, termed ACE3, in several mammalian genomes. The ACE3 gene is located on the same chromosome downstream of the ACE gene. Multiple ...

  14. Reducing marine mammal bycatch in global fisheries: An economics approach

    Science.gov (United States)

    Lent, Rebecca; Squires, Dale

    2017-06-01

    The broader ecosystem impacts of fishing continue to present a challenge to scientists and resource managers around the world. Bycatch is of greatest concern for marine mammals, for which fishery bycatch and entanglement is the number one cause of direct mortality. Climate change will only add to the challenge, as marine species and fishing practices adapt to a changing environment, creating a dynamic pattern of overlap between fishing and species (both target and bycatch). Economists suggest policy instruments for reducing bycatch that move away from top-down, command-and-control measures (e.g. effort reduction, time/area closures, gear restrictions, bycatch quotas) towards an approach that creates incentives to reduce bycatch (e.g. transferable bycatch allowances, taxes, and other measures). The advantages of this flexible, incentive-oriented approach are even greater in a changing and increasingly variable environment, as regulatory measures would have to be adapted constantly to keep up with climate change. Unlike the regulatory process, individual operators in the fishery sector can make adjustments to their harvesting practices as soon as the incentives for such changes are apparent and inputs or operations can be modified. This paper explores policy measures that create economic incentives not only to reduce marine mammal bycatch, but also to increase compliance and induce technological advances by fishery operators. Economists also suggest exploration of direct economic incentives as have been used in other conservation programs, such as payments for economic services, in an approach that addresses marine mammal bycatch as part of a larger conservation strategy. Expanding the portfolio of mandatory and potentially, voluntary, measures to include novel approaches will provide a broader array of opportunities for successful stewardship of the marine environment.

  15. Economic Sustainability in International Business: Peculiarities, Methods and Approaches

    Directory of Open Access Journals (Sweden)

    Otenko Iryna Pavlivna

    2016-05-01

    Full Text Available This article is intended as a contribution to the ongoing analysis of economic sustainability in international business. This study is presented with a view toward further understanding and agreement of the key concepts of sustainability. Approaches to sustainability are considered, important benchmarks and essential characteristics of sustainable development in international business are included. The article demonstrates how the concept of economic sustainability can be applied to the business level. The main ideas of the most widespread concepts on resource management are presented. Incorporation of ESG and financial factors in the concept of sustainable investing is considered. Emissions that are responsible for climate change, namely top emitters, key issues and figures are presented.

  16. Modern environmental and economic approach of mining industry

    Directory of Open Access Journals (Sweden)

    Carsten Drebenstedt

    2013-03-01

    Full Text Available In the article, the need of transition to the rational subsoil use (the alternative mining approach is proved, which unlike general one supposes the increasing of extraction rate of valuable components in the deposit and multiple use of raw materials, the maximizing recycling, the decreasing of land occupation, the increasing of the development period of deposit at some income decrease up to the moderate level, which is enough to provide the attraction for investors. The multicriteriality is considered as the crucial principle of rational subsoil use at taking management decisions, i.e. the considering of ecological, economic and social targets, aimed at receiving moderate profit at proper social and environmental standards. The graphic representation of models of the general mining approach and the alternative one allows to emphasize the specified advantages of transition to rational subsoil resources development and reflect them in design equation. In the paper, three performance strategies providing the implementation of the alternative approach are offered: full-field development, application ecologically and economically effective systems and the development processes, consideration of reclamation and minimization of long term environmental effects of mining

  17. Decision-theoretic approaches to non-knowledge in economics

    OpenAIRE

    Svetlova, Ekaterina; van Elst, Henk

    2014-01-01

    We review two strands of conceptual approaches to the formal representation of a decision maker's non-knowledge at the initial stage of a static one-person, one-shot decision problem in economic theory. One focuses on representations of non-knowledge in terms of probability measures over sets of mutually exclusive and exhaustive consequence-relevant states of Nature, the other deals with unawareness of potentially important events by means of sets of states that are less complete than the ful...

  18. [Rational drug use: an economic approach to decision making].

    Science.gov (United States)

    Mota, Daniel Marques; da Silva, Marcelo Gurgel Carlos; Sudo, Elisa Cazue; Ortún, Vicente

    2008-04-01

    The present article approaches rational drug use (RDU) from the economical point of view. The implementation of RDU implies in costs and involves acquisition of knowledge and behavioral changes of several agents. The difficulties in implementing RDU may be due to shortage problems, information asymmetry, lack of information, uncertain clinical decisions, externalities, time-price, incentives for drug prescribers and dispensers, drug prescriber preferences and marginal utility. Health authorities, among other agencies, must therefore regularize, rationalize and control drug use to minimize inefficiency in pharmaceutical care and to prevent exposing the population to unnecessary health risks.

  19. Risk as economic category: systematics scientific approach and refinement contents

    OpenAIRE

    V.G. Vygovskyy

    2015-01-01

    The paper studies the categorical-conceptual apparatus of risk and its refinement based on a critical analysis of existing systematic scientific approaches. Determined that in the refinement of the economic nature of the risk of a number of controversial issues: the definition of the objective or subjective nature of risk; matching of concepts such as «risk», «danger», «loss», «probability of loss»; definition of negative or positive consequences of risk; identification of risk with its conse...

  20. Approaches to Identification of Institutions in Institutional Economics

    Directory of Open Access Journals (Sweden)

    Igor M. Shiriaev

    2017-03-01

    Full Text Available The paper deals with the methodology for identification of institutions from institutional economics perspective. The differences between the perspectives provided by old and new institutional economics are highlighted. These differences are interpreted in the context of compared pragmatist and postpositivist methodologies. This paper applies to the post-positivist approach to the identification of institutions. One example of institution is provided by power-property institution. Identification of this institution in the historical and economic research is based on several theoretical generalizations and supported by array of historical facts. Another example is provided by identification of institution and institutional change in higher education based on discourse analysis and interviews with the main actors. In this paper, the regulatory institutions of higher education are analyzed as well. The concept of power-property institution is extended to the higher education by proposing hypotheses on the functioning of state governing-regulating institution in this sphere. This institution prescribes the actors to behave in accordance with the objectives of public policy, which can only be implemented in the form of bureaucratization of higher education. The paper describes the behavioral regularity generated by an identified institution. Functioning of the governing-regulating institution in higher education is illustrated by examples of behavioral regularities emerging from activities in accordance with this institution. The paper also shows the possibility of falsification of proposed hypothesis.

  1. The economics of gasification: a market-based approach

    Energy Technology Data Exchange (ETDEWEB)

    Abadie, L. M. [Bilbao Bizkaia Kutxa, Gran Via 30, 48009 Bilbao (Spain); Chamorro, J. M. [Departamento Fundamentos del Analisis Economico I, University of the Basque Country, Av. Lehendakari Aguirre 83, 48015 Bilbao (Spain)

    2009-07-01

    This paper deals with the economics of gasification facilities in general and Integrated Gasification Combined Cycle (IGCC) power plants in particular. Regarding the prospects of these systems, passing the technological test is one thing, passing the economic test can be quite another. In this respect, traditional valuations assume constant input and/or output prices. Since this is hardly realistic, we allow for uncertainty in prices. We naturally look at the markets where many of the products involved are regularly traded. Futures markets on commodities are particularly useful for valuing uncertain future cash flows. Thus, revenues and variable costs can be assessed by means of sound financial concepts and actual market data. On the other hand, these complex systems provide a number of flexibility options (e.g., to choose among several inputs, outputs, modes of operation, etc.). Typically, flexibility contributes significantly to the overall value of real assets. Indeed, maximization of the asset value requires the optimal exercise of any flexibility option available. Yet the economic value of flexibility is elusive, the more so under (price) uncertainty. And the right choice of input fuels and/or output products is a main concern for the facility managers. As a particular application, we deal with the valuation of input flexibility. We follow the Real Options approach. In addition to economic variables, we also address technical and environmental issues such as energy efficiency, utility performance characteristics and emissions (note that carbon constraints are looming). Lastly, a brief introduction to some stochastic processes suitable for valuation purposes is provided. (author)

  2. The economics of gasification: a market-based approach

    International Nuclear Information System (INIS)

    Abadie, L. M.; Chamorro, J. M.

    2009-01-01

    This paper deals with the economics of gasification facilities in general and Integrated Gasification Combined Cycle (IGCC) power plants in particular. Regarding the prospects of these systems, passing the technological test is one thing, passing the economic test can be quite another. In this respect, traditional valuations assume constant input and/or output prices. Since this is hardly realistic, we allow for uncertainty in prices. We naturally look at the markets where many of the products involved are regularly traded. Futures markets on commodities are particularly useful for valuing uncertain future cash flows. Thus, revenues and variable costs can be assessed by means of sound financial concepts and actual market data. On the other hand, these complex systems provide a number of flexibility options (e.g., to choose among several inputs, outputs, modes of operation, etc.). Typically, flexibility contributes significantly to the overall value of real assets. Indeed, maximization of the asset value requires the optimal exercise of any flexibility option available. Yet the economic value of flexibility is elusive, the more so under (price) uncertainty. And the right choice of input fuels and/or output products is a main concern for the facility managers. As a particular application, we deal with the valuation of input flexibility. We follow the Real Options approach. In addition to economic variables, we also address technical and environmental issues such as energy efficiency, utility performance characteristics and emissions (note that carbon constraints are looming). Lastly, a brief introduction to some stochastic processes suitable for valuation purposes is provided. (author)

  3. Advanced Collaborative Emissions Study (ACES)

    Energy Technology Data Exchange (ETDEWEB)

    Greenbaum, Daniel; Costantini, Maria; Van Erp, Annemoon; Shaikh, Rashid; Bailey, Brent; Tennant, Chris; Khalek, Imad; Mauderly, Joe; McDonald, Jacob; Zielinska, Barbara; Bemis, Jeffrey; Storey, John; Hallberg, Lance; Clark, Nigel

    2013-12-31

    The objective of the Advanced Collaborative Emissions Study (ACES) was to determine before widespread commercial deployment whether or not the new, energy-efficient, heavy duty diesel engines (2007 and 2010 EPA Emissions Standards Compliant) may generate anticipated toxic emissions that could adversely affect the environment and human health. ACES was planned to take place in three phases. In Phase 1, extensive emissions characterization of four production-intent prototype engine and control systems designed to meet 2007 standards for nitrogen oxides (NOx) and particulate matter (PM) was conducted at an existing emissions characterization facility: Southwest Research Institute (SwRI). One of the tested engines was selected (at random, after careful comparison of results) for health testing in Phase 3. In Phase 2, extensive emission characterization of three production-intent prototype engine and control systems meeting the 2010 standards (including more advanced NOx controls to meet the more stringent 2010 NOx standards) was conducted at the same test facility. In Phase 3, one engine/aftertreatment system selected from Phase 1 was further characterized during health effects studies (at an existing inhalation toxicology laboratory: Lovelace Respiratory Research Institute, [LRRI]) to form the basis of the ACES safety assessment. The Department of Energy (DOE) award provided funding for emissions characterization in Phases 1 and 2 as well as exposure characterization in Phase 3. The main health analyses in Phase 3 were funded separately and are not reported here.

  4. Economism

    Directory of Open Access Journals (Sweden)

    P. Simons

    2010-07-01

    Full Text Available Modern society is characterised not only by a fascination with scientific technology as a means of solving all problems, especially those that stand in the way of material progress (technicism, but also by an obsessive interest in everything that has to do with money (economism or mammonism. The article discusses the relationship between technicism and economism, on the basis of their relationship to utilitarian thinking: the quest for the greatest happiness for the greatest number of people. Recent major studies of neo-liberalism (seen as an intensification of utilitarianism by Laval and Dardot are used as reference to the development of utilitarianism. It is suggested that the western view of the world, as expressed in economism and technicism, with a utilitarian ethics, features three absolutisations: those of theoretical thinking, technology and economics. In a second part, the article draws on the framework of reformational philosophy to suggest an approach that, in principle, is not marred by such absolutisations.

  5. Risk as economic category: systematics scientific approach and refinement contents

    Directory of Open Access Journals (Sweden)

    V.G. Vygovskyy

    2015-03-01

    Full Text Available The paper studies the categorical-conceptual apparatus of risk and its refinement based on a critical analysis of existing systematic scientific approaches. Determined that in the refinement of the economic nature of the risk of a number of controversial issues: the definition of the objective or subjective nature of risk; matching of concepts such as «risk», «danger», «loss», «probability of loss»; definition of negative or positive consequences of risk; identification of risk with its consequences, or source of origin, which makes the relevance of research topics. As a result of scientific research has been refined interpretation of risk as an economic category, the characteristics of the company associated with the probability of unforeseen situations that may lead to negative and positive impacts, assessment of which requires the development of alternatives for management decisions. Clarification of the definition focuses on the possibility (probability of a favorable (unfavorable events which require certain corrective action management unit of the enterprise. The author emphasizes the mandatory features of the category of «risk», in particular: the concept of risk is always associated with the uncertainty of the future; event occurring has implications for the enterprise (both negative and positive; consequences for necessitates the development of a number of alternative solutions to the possible elimination of the negative consequences of risky events; risk – a mandatory attribute of modern management (its value is enhanced in terms of market conditions; subject to risk assessment and management by the company. Dedicated and updated features contribute to the clarification of the nature of the economic risk and categorical conceptual apparatus of risk management.

  6. Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

    NARCIS (Netherlands)

    H. Schelleman (Hedi); O.H. Klungel (Olaf); C.M. van Duijn (Cornelia); J.C.M. Witteman (Jacqueline); A. Hofman (Albert); A.C. de Boer (Anton); B.H.Ch. Stricker (Bruno)

    2005-01-01

    textabstractAims: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug. Methods: This was a cohort study among 239 subjects who

  7. POMB/ACE chemotherapy for mediastinal germ cell tumours.

    Science.gov (United States)

    Bower, M; Brock, C; Holden, L; Nelstrop, A; Makey, A R; Rustin, G J; Newlands, E S

    1997-05-01

    Mediastinal germ cell tumours (MGCT) are rare and most published series reflect the experiences of individual institutions over many years. Since 1979, we have treated 16 men (12 non-seminomatous germ cell tumours and 4 seminomas) with newly diagnosed primary MGCT with POMB/ACE chemotherapy and elective surgical resection of residual masses. This approach yielded complete remissions in 15/16 (94%) patients. The median follow-up was 6.0 years and no relapses occurred more than 2 years after treatment. The 5 year overall survival in the non-seminomatous germ cell tumours (NSGCT) is 73% (95% confidence interval 43-90%). One patient with NSGCT developed drug-resistant disease and died without achieving remission and 2 patients died of relapsed disease. In addition, 4 patients with bulky and/or metastatic seminoma were treated with POMB/ACE. One died of treatment-related neutropenic sepsis in complete remission and one died of relapsed disease. Finally, 4 patients (2 NSGCT and 2 seminomas) referred at relapse were treated with POMB/ACE and one was successfully salvaged. The combination of POMB/ACE chemotherapy and surgery is effective management for MGCT producing high long-term survival rates.

  8. Essays in political economy and resource economic : A macroeconomic approach

    NARCIS (Netherlands)

    Rodriguez Acosta, Mauricio

    2016-01-01

    This dissertation consists of four chapters in Political Economy and Resource Economics from a macroeconomic perspective. This collection of works emphasizes the endogenous nature of institutions and their importance for economic development. The four chapters revolve around two central questions:

  9. Measuring energy efficiency in economics: Shadow value approach

    Science.gov (United States)

    Khademvatani, Asgar

    For decades, academic scholars and policy makers have commonly applied a simple average measure, energy intensity, for studying energy efficiency. In contrast, we introduce a distinctive marginal measure called energy shadow value (SV) for modeling energy efficiency drawn on economic theory. This thesis demonstrates energy SV advantages, conceptually and empirically, over the average measure recognizing marginal technical energy efficiency and unveiling allocative energy efficiency (energy SV to energy price). Using a dual profit function, the study illustrates how treating energy as quasi-fixed factor called quasi-fixed approach offers modeling advantages and is appropriate in developing an explicit model for energy efficiency. We address fallacies and misleading results using average measure and demonstrate energy SV advantage in inter- and intra-country energy efficiency comparison. Energy efficiency dynamics and determination of efficient allocation of energy use are shown through factors impacting energy SV: capital, technology, and environmental obligations. To validate the energy SV, we applied a dual restricted cost model using KLEM dataset for the 35 US sectors stretching from 1958 to 2000 and selected a sample of the four sectors. Following the empirical results, predicted wedges between energy price and the SV growth indicate a misallocation of energy use in stone, clay and glass (SCG) and communications (Com) sectors with more evidence in the SCG compared to the Com sector, showing overshoot in energy use relative to optimal paths and cost increases from sub-optimal energy use. The results show that energy productivity is a measure of technical efficiency and is void of information on the economic efficiency of energy use. Decomposing energy SV reveals that energy, capital and technology played key roles in energy SV increases helping to consider and analyze policy implications of energy efficiency improvement. Applying the marginal measure, we also

  10. THE WAY OF PROCESSING DATA IN APPROACHING ECONOMIC APPLICATIONS

    Directory of Open Access Journals (Sweden)

    ADRIAN GHENCEA

    2012-05-01

    Full Text Available Economic Informatics originates in the industry economy and the electronic processing of information. A clear distinction is made between IT and economic informatics, and further between general and particular economic informatics (the particular economic informatics meaning administration, industrial informatics etc. Economic informatics is deemed to be an applicative science relating to the conception, working modality and representation of IT and communication systems, oriented towards companies which are using electronic computers. This paper pursues to integrate applications allowing the information systems to interconnect at informational level, by information sharing, and at service level, considering the control of the related processes in real time.

  11. Methods to Assess Adverse Childhood Experiences of Children and Families: Toward Approaches to Promote Child Well-being in Policy and Practice.

    Science.gov (United States)

    Bethell, Christina D; Carle, Adam; Hudziak, James; Gombojav, Narangerel; Powers, Kathleen; Wade, Roy; Braveman, Paula

    supported a cumulative risk scoring method. Formative as well as reflective measurement models further support cumulative risk scoring and provide evidence of predictive validity of the NSCH-ACEs. Common effects of ACEs across household income groups confirm information distinct from economic status is provided and suggest use of population-wide versus high-risk approaches to assessing ACEs. Although important variations exist, available ACEs measurement methods are similar and show consistent associations with poorer health outcomes in absence of protective factors and resilience. All methods reviewed appear to coincide with broader goals to facilitate health education, promote health and, where needed, to mitigate the trauma, chronic stress, and behavioral and emotional sequelae that can arise with exposure to ACEs. Assessing ACEs appears acceptable to individuals and families when conducted in population-based and clinical research contexts. Although research to date and neurobiological findings compel early identification and health education about ACEs in clinical settings, further research to guide use in pediatric practice is required, especially as it relates to distinguishing ACEs assessment from identifying current family psychosocial risks and child abuse. The reflective as well as formative psychometric analyses conducted in this study confirm use of cumulative risk scoring for the NSCH-ACEs measure. Even if children have not been exposed to ACEs, assessing ACEs has value as an educational tool for engaging and educating families and children about the importance of SSNRs and how to recognize and manage stress and learn resilience. Copyright © 2017 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  12. Photonomics: automation approaches yield economic aikido for photonics device manufacture

    Science.gov (United States)

    Jordan, Scott

    2002-09-01

    In the glory days of photonics, with exponentiating demand for photonics devices came exponentiating competition, with new ventures commencing deliveries seemingly weekly. Suddenly the industry was faced with a commodity marketplace well before a commodity cost structure was in place. Economic issues like cost, scalability, yield-call it all "Photonomics" -now drive the industry. Automation and throughput-optimization are obvious answers, but until now, suitable modular tools had not been introduced. Available solutions were barely compatible with typical transverse alignment tolerances and could not automate angular alignments of collimated devices and arrays. And settling physics served as the insoluble bottleneck to throughput and resolution advancement in packaging, characterization and fabrication processes. The industry has addressed these needs in several ways, ranging from special configurations of catalog motion devices to integrated microrobots based on a novel mini-hexapod configuration. This intriguing approach allows tip/tilt alignments to be automated about any point in space, such as a beam waist, a focal point, the cleaved face of a fiber, or the optical axis of a waveguide- ideal for MEMS packaging automation and array alignment. Meanwhile, patented new low-cost settling-enhancement technology has been applied in applications ranging from air-bearing long-travel stages to subnanometer-resolution piezo positioners to advance resolution and process cycle-times in sensitive applications such as optical coupling characterization and fiber Bragg grating generation. Background, examples and metrics are discussed, providing an up-to-date industry overview of available solutions.

  13. Economic responses to global warming: Prospects for cooperative approaches

    International Nuclear Information System (INIS)

    Schelling, T.C.

    1991-01-01

    At the outset, any cooperative approach to global warming will have to reach some rough consensus on two sets of magnitudes and the marginal trade-off between them. One set of magnitudes relates to CO 2 production and abatement. It is the cost and difficulties of reducing energy use by households, farms, and industry, and of switching to cleaner fossil fuels or converting to nonfossil energies. These are the kinds of things that economists and engineers, sometimes sociologists and architects, have been working on with special motivation since 1973. The uncertainties remain great, and they increase many-fold when projected to the middle of the next century. But these estimates do receive attention. The other set of magnitudes has to do with the impact of changing climate on economic productivity, on health and comfort, on the quality of life in general, and on the differential rates of progress among countries. These estimates, on which virtually no work was done until recently, are doubly uncertain. In this study the author offers a judgment about the magnitude of the consequences of failing to reduce CO 2 emissions drastically below what they would be in the absence of such an effort. The author takes 'drastic' to mean anything between an emissions growth rate half of what it would otherwise be and an emissions growth rate of zero beginning one or two decades from now - that is, annual emissions leveling off within a decade or two. That level would still leave emissions growing at the maximum achieved rate

  14. Austrian Economics and the Transaction Cost Approach to the Firm

    Directory of Open Access Journals (Sweden)

    Nicolai J. Foss

    2009-10-01

    Full Text Available As the transaction cost theory of the firm was taking shape in the 1970s, another important movement in economics was emerging: a revival of the ‘Austrian’ tradition in economic theory associated with such economists as Ludwig von Mises and F. A. Hayek (1973; Dolan, 1976; Spadaro, 1978. As Oliver Williamson has pointed out, Austrian economics is among the diverse sources for transaction cost economics. In particular, Williamson frequently cites Hayek (e.g., Williamson, 1985, p. 8; 1991, p. 162, particularly Hayek’s emphasis on adaptation as a key problem of economic organisation (Hayek, 1945. Following Williamson’s lead, a reference to Hayek’s ‘The Use of Knowledge in Society’ (Hayek, 1945 has become almost mandatory in discussions of economic organisation (e.g., Ricketts, 1987, p. 59; Milgrom and Roberts, 1992, p. 56; Douma and Schreuder 1991, p. 9. However, there are many other potential links between Austrian and transaction cost economics that have not been explored closely and exploited.This article argues that characteristically Austrian ideas about property, entrepreneurship, economic calculation, tacit knowledge, and the temporal structure of capital have important implications for theories of economic organisation, transaction cost economics in particular. Austrian economists have not, however, devoted substantial attention to the theory of the firm, preferring to focus on business-cycle theory, welfare economics, political economy, comparative economic systems, and other areas. Until recently the theory of the firm was an almost completely neglected area in Austrian economics, but over the last decade, a small Austrian literature on the firm has emerged. While these works cover a wide variety of theoretical and applied topics, their authors share the view that Austrian insights have something to offer students of firm organisation.

  15. Fine-Mapping Angiotensin-Converting Enzyme Gene: Separate QTLs Identified for Hypertension and for ACE Activity

    Science.gov (United States)

    Chung, Chia-Min; Wang, Ruey-Yun; Fann, Cathy S. J.; Chen, Jaw-Wen; Jong, Yuh-Shiun; Jou, Yuh-Shan; Yang, Hsin-Chou; Kang, Chih-Sen; Chen, Chien-Chung; Chang, Huan-Cheng; Pan, Wen-Harn

    2013-01-01

    Angiotensin-converting enzyme (ACE) has been implicated in multiple biological system, particularly cardiovascular diseases. However, findings associating ACE insertion/deletion polymorphism with hypertension or other related traits are inconsistent. Therefore, in a two-stage approach, we aimed to fine-map ACE in order to narrow-down the function-specific locations. We genotyped 31 single nucleotide polymorphisms (SNPs) of ACE from 1168 individuals from 305 young-onset (age ≤40) hypertension pedigrees, and found four linkage disequilibrium (LD) blocks. A tag-SNP, rs1800764 on LD block 2, upstream of and near the ACE promoter, was significantly associated with young-onset hypertension (p = 0.04). Tag-SNPs on all LD blocks were significantly associated with ACE activity (p-value: 10–16 to ACE activity were found between exon13 and intron18 and between intron 20 and 3′UTR, as revealed by measured haplotype analysis. These two major QTLs of ACE activity and the moderate effect variant upstream of ACE promoter for young-onset hypertension were replicated by another independent association study with 842 subjects. PMID:23469169

  16. From entrepreneurship to economic growth: a three stage approach

    NARCIS (Netherlands)

    van Hemert, P.P.

    2008-01-01

    Over time, different economic theories have supported the idea that entrepreneurship and innovation are essential for spurring economic growth. One question, however, remains unanswered, namely, why some regions in different parts of the world manage to enter into a cycle of growth and development

  17. From entrepreneurship to economic growth, a three stage approach

    NARCIS (Netherlands)

    van Hemert, P.P.

    2007-01-01

    Over time, different economic theories have supported the idea that entrepreneurship and innovation are essential for spurring economic growth. One question, however, remains unanswered, namely, why some regions in different parts of the world manage to enter into a cycle of growth and development

  18. Emotions, perceptions and economic behavior. A critical-philosophical approach to the place of Psychology in Economics

    Directory of Open Access Journals (Sweden)

    Vicente Caballero de la Torre

    2012-10-01

    Full Text Available This paper presents the origin of the issue of empathy in the History of Ideas and its importance in economics, as well as its revitalization. It concludes that it is not the study of empathy, so fashionable today, but the study of decision making the place where Economics can find the nature of emotions in relation to human behavior. This nature is its power to inhibit behavior. The study of repentance is itself more interesting and helpful for the economy than the study of empathy. Finally, the institutional approach is presented as the best in order to understand the issues related to economic human behavior

  19. Undergraduate Research and Economic Development: A Systems Approach in Wisconsin

    Science.gov (United States)

    Van Galen, Dean; Schneider-Rebozo, Lissa; Havholm, Karen; Andrews, Kris

    2015-01-01

    This chapter presents the state of Wisconsin and the University of Wisconsin System as an ongoing case study for best practices in systematic, intentional, statewide programming and initiatives connecting undergraduate research and economic development.

  20. Simulated annealing approach for solving economic load dispatch ...

    African Journals Online (AJOL)

    user

    thermodynamics to solve economic load dispatch (ELD) problems. ... evolutionary programming algorithm has been successfully applied for solving the ... concept behind the simulated annealing (SA) optimization is discussed in Section 3.

  1. ARDL Approach to Trade Libralisation and Economic Growth in the ...

    African Journals Online (AJOL)

    Nneka Umera-Okeke

    the long and short run impact of trade liberalization to economic growth suggested that ..... To ensure the goodness of fit of the model, diagnostic and stability tests are conducted. .... The results indicate the absence of any instability of the.

  2. A Transactions Cost Economics (TCE) Approach to Optimal Contract Type

    OpenAIRE

    Franck, Raymond; Melese, Francois; Dillard, John

    2006-01-01

    Proceedings Paper (for Acquisition Research Program) This study examines defense acquisition through the new lens of Transaction Cost Economics (TCE). TCE is an emergent field in economics that has multiple applications to defense acquisition practices. TCE''s original focus was to guide ''make-or-buy?'' decisions that define the boundaries of a firm. This study reviews insights afforded by TCE that impact government outsourcing (''buy'' decisions), paying special attention to defense pro...

  3. Estimating economic losses from earthquakes using an empirical approach

    Science.gov (United States)

    Jaiswal, Kishor; Wald, David J.

    2013-01-01

    We extended the U.S. Geological Survey's Prompt Assessment of Global Earthquakes for Response (PAGER) empirical fatality estimation methodology proposed by Jaiswal et al. (2009) to rapidly estimate economic losses after significant earthquakes worldwide. The requisite model inputs are shaking intensity estimates made by the ShakeMap system, the spatial distribution of population available from the LandScan database, modern and historic country or sub-country population and Gross Domestic Product (GDP) data, and economic loss data from Munich Re's historical earthquakes catalog. We developed a strategy to approximately scale GDP-based economic exposure for historical and recent earthquakes in order to estimate economic losses. The process consists of using a country-specific multiplicative factor to accommodate the disparity between economic exposure and the annual per capita GDP, and it has proven successful in hindcast-ing past losses. Although loss, population, shaking estimates, and economic data used in the calibration process are uncertain, approximate ranges of losses can be estimated for the primary purpose of gauging the overall scope of the disaster and coordinating response. The proposed methodology is both indirect and approximate and is thus best suited as a rapid loss estimation model for applications like the PAGER system.

  4. THE ECONOMIC APPROACH OF ECOSYSTEM SERVICES PROVIDED BY PROTECTED AREAS

    Directory of Open Access Journals (Sweden)

    Cirnu Maria

    2015-07-01

    Full Text Available As practice shows us, at the present time ecosystem services are recognized by humanity, but unfortunately are undervalued compared to their full potential. Most of planet's ecosystems are degradated by anthropic activity of humankind. It is almost impossible to say that there are no areas affected by human activity, however, the Protected Areas are a good opportunity, so the assessing of ecosystem services in Protected Areas can be a solution to the problem of economic growth. At present, there are few consistent informations on economic value of ecosystem services in Romania, on the basis of which can be adopted some sustainable financing policies of activities in Protected Areas. The premise from which we start is that a proper management of natural capital will allow biodiversity conservation and human well-being if it find appropriate economic instruments. For this reason, studies of economic research on the contribution of those ecosystem services to the communities welfare may constitute credible means for decision-makers, demonstrating the Protected Areas importance. This paper, based on the study of international and national literature, examines the state of knowledge on the economic and environmental valences of ecosystem services. The growing interest of researchers regarding the economic valuation of ecosystem services related to Protected Areas is visible through the many studies carried out at international level. Although national scientific research relating to ecosystem services is at the beginning, concerns researchers economists and ecologists have been directed toward this recess, of ecosystem services. The reason for we should assign an economic value to ecosystem services is to ensure that their value is included actively in decision-making and is not ignored because "is still available". Briefly, the paper start with an overview of the main definition of ecosystem services. From the point of economic value view, the paper

  5. Strong sustainability in Nepal: A structural economics approach

    Science.gov (United States)

    Devkota, Surendra R.

    This dissertation analyzes the sustainability of the economy of Nepal. The main empirical question addressed is whether the Tenth Plan of Nepal (2002--2007) will meet its projected economic output goal and achieve its primary goal of reducing poverty. To this end, economic growth scenarios are examined in terms of availability of energy demand and supply, and income disparity among different households. The structure of the Nepali economy is examined using a Leontief input-output table, a Ghosian supply-side input-output table, and a social accounting matrix for the year 1999. Based on the input-output analysis of energy demand and supply for the 10th Plan, it is unlikely that energy requirements of the projected output will be met, unless some extra sources of energy are developed. Households need to switch their energy use from fuel wood/biomass to other alternatives. In order to meet the target of the Plan vis-a-vis energy demand or supply, a few policy measures are urgently needed, though some of these options require many years to develop. Household income inequality and distribution is examined through the SAM multipliers; namely aggregate, transfer, open-loop, and closed-loop multipliers. The investment-income multiplier scenarios for the 10th Plan indicate that the nominal income of households may increase due to the increased investment, which will not necessarily improve the bottom deciles households, particularly socio-economically deprived households. Economic growth in Nepal during the past fifty years demonstrates that the modernization model is unsuccessful. Economic growth occurred at some centers at the cost of periphery. A huge regional disparity has developed between hills and plains, east and west, city and rural areas. Nepal's persistent poverty indicates a failure of modernization theory. The Tenth Plan would be another continuation of a failed legacy, unless social and natural endowments are considered for sustainability. Nepal could be an

  6. ACE polymorphism does not determine short-term renal response to ACE-inhibition in proteinuric patients

    NARCIS (Netherlands)

    vanderKleij, FGH; Navis, GJ; Gansevoort, RT; Scheffer, H; deZeeuw, D; deJong, PE

    1997-01-01

    Background. The renal response to ACE inhibition is known to vary between individuals. The ACE genotype is a determinant of the ACE concentrations in plasma and tissue, and therefore might affect the renal response to ACE inhibition in renal patients. Methods. To test this hypothesis we studied the

  7. Alabama Cooperative Extension System - ACES.edu

    Science.gov (United States)

    Marshall Mobile Monroe Montgomery Morgan Perry Pickens Pike Randolph Russell Shelby St. Clair Sumter Marengo Tuscaloosa Greene Pickens Sumter Conecuh Escambia Monroe Clarke Choctaw Washington Baldwin Mobile Office Communications & Marketing Information Technology ACES Publications & Store 4-H &

  8. Is the “Ecological and Economic Approach for the Restoration of Collapsed Gullies” in Southern China Really Economic?

    Directory of Open Access Journals (Sweden)

    Chengchao Wang

    2015-07-01

    Full Text Available Collapsed gully erosion constantly plagues the sustainability of rural areas in China. To control collapsed gully erosion, an ecological and economic approach, which uses tree plantation to gain economic benefits and control soil erosion, has been widely applied by local governments in Southern China. However, little is known about the economic feasibility of this new method. The objective of this study was to determine the effectiveness and economic benefits of the new method. Based on a case study in Changting County, Southeast China, two farms were selected to represent a timber tree plantation and a fruit tree plantation, respectively. The Annual Capital Capitalization Method and Return on Investment (ROI were selected to conduct cost-benefit analysis. In contrast to previous studies, we found that the new approach was far from economic. The value of the newly-built forestland in Sanzhou Village and Tufang Village is 2738 RMB ha−1 and 5477 RMB ha−1, respectively, which are extremely lower than the costs of ecological restoration. Meanwhile, the annual ROI is −3.60% and −8.90%, respectively, which is negative and also far poorer than the average value of forestry in China. The costs of conservation were substantially over the related economic benefits, and the investors would suffer from greater loss if they invested more in the conservation. Low-cost terraces with timber trees had less economic loss compared with the costly terraces with fruit tree plantation. Moreover, the cost efficiency of the new approaches in soil conservation was also greatly poorer than the conventional method. The costs of conserving one ton soil per year for conventional method, new method for planting timber trees, and planting fruit trees were 164 RMB, 696 RMB, and 11,664 RMB, respectively. Therefore, the new collapsed gully erosion control methods are uneconomic and unsuitable to be widely carried out in China in the near future.

  9. Problems of Economic Development in Reunified Germany. Retrospective Approach

    Directory of Open Access Journals (Sweden)

    Marta Gotz

    2011-07-01

    Full Text Available Does Eastern Germany differ significantly from Western part in economic terms? How have new Bundeslnder been developing over past twenty years? How fast has East been catching up with West? What could have hampered convergence? How today are German states equipped with factors determining future growth? How the new Bundeslnder performed do compared with the old ones? This paper seeks to address above mentioned questions. It offers a comprehensive review of key economic developments of two decades of reunited Germany. Particularly it examines current economic landscape; investigates convergence processes taking place since reunification and tries to identify most likely impediments hampering full catching up. Finally, it aims at assessing contemporary growth potential of German states. With respect to the starting point poor performance of East Germany back in 1990 the progress made and results achieved are impressive. Though, comparing the situation with Western part of the country significant discrepancies continue to exist. Certainly, assessment of the last twenty years of reunited Germany hinges much upon perspective taken. Two decades after Berlin Wall Fall opinions on economic consequences of reunification are more balanced, since much has been achieved, but much still needs to be done.

  10. An Economic Approach to Planting Trees for Carbon Storage

    Science.gov (United States)

    Peter J. Parks; David O. Hall; Bengt Kristrom; Omar R. Masera; Robert J. Multon; Andrew J. Plantinga; Joel N. Swisher; Jack K. Winjum

    1997-01-01

    Abstract: Methods are described for evaluating economic and carbon storage aspects of tree planting projects (e.g., plantations for restoration, roundwood, bioenergy, and nonwood products). Total carbon (C) stock is dynamic and comprises C in vegetation, decomposing matter, soil, products, and fuel substituted. An alternative (reference) case is...

  11. Effects of approach and withdrawal motivation on interactive economic decisions

    NARCIS (Netherlands)

    Harle, Katia; Sanfey, A.G.

    2010-01-01

    Although recent economic models of human decision making have recognised the role of emotion as an important biasing factor, the impact of incidental emotion on decisions has remained poorly explored. To address this question, we jointly explored the role of emotional valence (i.e., positive vs.

  12. Modeling and forecasting mortality with economic growth : a multipopulation approach

    NARCIS (Netherlands)

    Boonen, T.J.; Li, H.

    2017-01-01

    Research on mortality modeling of multiple populations focuses mainly on extrapolating past mortality trends and summarizing these trends by one or more common latent factors. This article proposes a multipopulation stochastic mortality model that uses the explanatory power of economic growth. In

  13. On the Economic Approach to Bilingual Education in China

    Science.gov (United States)

    Xiong, Zhiwei; Shao, Cheng

    2009-01-01

    In the process of globalization, each country culture retains an independence from the others besides in reality a fusion of several cultures. Bilingual education as an effective means and intangible resource, which have long been neglected, will play an important part in social and economic development in China. Bilingual education, in this…

  14. Spurring Economic Growth through Education: The Malaysian Approach

    Science.gov (United States)

    Rao, R. Ramesh; Jani, Rohana

    2009-01-01

    The economic progress made by many countries is attributed to many factors. Education is often quoted as a major contributing factor. There are many researches done in evaluating and determining the role of education in nations. In this paper, factors of education which have helped in the case of Malaysia are dwelled upon. Education has helped…

  15. Women's Marginalization, Economic Flows, and Environmental Flows: A Classroom Approach.

    Science.gov (United States)

    O'Lear, Shannon

    1999-01-01

    Discusses environmental security, focusing on the meaning of "security." Defines the global economy as a process in which the security of groups is sought, maintained, or threatened. Illustrates connections among environmental security, the global economy, and abuse of women and children in less economically developed places,…

  16. Theoretical and methodological approaches to economic competitiveness (Part I

    Directory of Open Access Journals (Sweden)

    Macari Vadim

    2013-01-01

    Full Text Available The article is based on study of several representative bibliographical sources,it is tried to examine, to order from logical and scientific point of view some of the most common theoretical and methodological understandings of the essence, definition, phenomenon, types, haracteristics and indices of economic competitiveness.

  17. Theoretical and methodological approaches to economic competitiveness (part II

    Directory of Open Access Journals (Sweden)

    Macari Vadim

    2013-02-01

    Full Text Available This article, on the basis of the study of many representative bibliographic sources, examines and tries to order from logical and scientific point of view some of the most common theoretical and methodological treatments of the essence, definition, phenomenon, types, characteristics and indices of economic competitiveness.

  18. THEORETICAL AND METHODOLOGICAL APPROACHES TO ECONOMIC COMPETITIVENESS (Part II

    Directory of Open Access Journals (Sweden)

    Vadim MACARI

    2013-02-01

    Full Text Available This article, on the basis of the study of many representative bibliographic sources, examines and tries to order from logical and scientific point of view some of the most common theoretical and methodological treatments of the essence, definition, phenomenon, types, characteristics and indices of economic competitiveness.

  19. THEORETICAL AND METHODOLOGICAL APPROACHES TO ECONOMIC COMPETITIVENESS (Part I

    Directory of Open Access Journals (Sweden)

    Vadim MACARI

    2013-01-01

    Full Text Available The article is based on study of several representative bibliographical sources,it is tried to examine, to order from logical and scientific point of view some of the most common theoretical and methodological understandings of the essence, definition, phenomenon, types, characteristics and indices of economic competitiveness.

  20. Approaches of Extension Specialists to Teaching Community and Economic Development.

    Science.gov (United States)

    Leones, Julie

    1995-01-01

    Responses from 64 of 80 extension agents specializing in community resources and economic development identified the "Journal of the Community Development Society" as the primary source of ideas and information. Frequently cited program topics were entrepreneurship, fiscal policy, budgeting, strategic planning, and leadership development. Among…

  1. Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes

    DEFF Research Database (Denmark)

    Johannesen, Jesper; Svensson, Jannet; Bergholdt, Regine

    2011-01-01

    OBJECTIVE: High S-ACE levels have been shown to predispose to increased risk of hypoglycemia, however; some inconsistency relates to the risk of the ACE genotype. We investigated the association between S-ACE level at diagnosis and ACE genotype to long-term risk of severe hypoglycemia in more than...... to increased risk of hypoglycemia generated from a negative binominal model were long diabetes duration (p high S-ACE level (p = 0.0497) when adjusted for ACE genotype. In the stratified analysis, S-ACE and insulin dosage were associated with hypoglycemia in girls (p = 0.026 and 0...

  2. Listing of Available ACE Data Tables

    Energy Technology Data Exchange (ETDEWEB)

    Conlin, Jeremy Lloyd [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-31

    This document is divided into multiple sections. Section 2 lists some of the more frequently used ENDF/B reaction types that can be used with the FM input card. The remaining sections (described below) contain tables showing the available ACE data tables for various types of data. These ACE data libraries are distributed by the Radiation Safety Information Computational Center (RSICC) with MCNP6.

  3. ACE Gene in Egyptian Ischemic Stroke Patients.

    Science.gov (United States)

    Mostafa, Magdy A; El-Nabiel, Lobna M; Fahmy, Nagia Aly; Aref, Hany; Shreef, Edrees; Abd El-Tawab, Fathy; Abdulghany, Osama M

    2016-09-01

    Angiotensin-1-converting enzyme (ACE) is a crucial player in vascular homeostasis and in the pathogenesis of atherosclerosis and hypertension. The present study was conducted to determine whether there is an association between the ACE insertion/deletion (I/D) polymorphism and ischemic stroke in Egyptian population. Also, we analyzed the ACE gene I/D polymorphism as a risk factor for small-vessel (SV) versus large-vessel (LV) disease. Sixty patients with ischemic stroke were included: 30 with SV disease and 30 with LV disease. In addition, a control group of 30 apparent healthy subjects were studied. Clinical assessment, computed tomography, magnetic resonance imaging brain, and genetic study using the polymerase chain reaction of ACE gene were done for all subjects. We found that the distribution of ACE gene polymorphism frequency was significantly different between the 3 groups. The DD genotype was far more common in stroke patients compared to controls. It was also significantly more common in each of the patient groups compared to controls but rather similar in the 2 patient groups with SV and LV diseases. We found that the ACE gene deletion/deletion genotype is common in Egyptian patients with non-cardioembolic ischemic stroke but does not appear to be specific neither to SV nor to LV disease. Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  4. A new approach towards the enhancement of northeast Asian economic cooperation

    Directory of Open Access Journals (Sweden)

    Chang-Jae Lee

    1999-09-01

    Full Text Available This study proposes the formation of the Northeast Asian Economic Cooperation Council (NAECC to discuss comprehensive economic cooperation and major economic issues between Korea, Japan and China. In order to meet the challenge of risign regionalism and to prevent another Asian economic crisis, it is imperative for the central governments of the region to involve themselves more actively in Northeast Asian Economic Cooperation. Given the diversity of Northeast Asian countries, it seems to be more realistic to vegin with the central governments of the three major countries in terms of economic size. However, even amongst these three countries, the prospects for reaching a regional trade agreement such as the North American Free Trade Agreement (NAFTA, let alone a more advanced economic integration type like the EU, are quite dim in the foreseeable future. Thus, Korea, Japan and China must try to get as many benefits of economic integration as possible through a non-traditional approach.

  5. Modeling and Forecasting Mortality With Economic Growth: A Multipopulation Approach.

    Science.gov (United States)

    Boonen, Tim J; Li, Hong

    2017-10-01

    Research on mortality modeling of multiple populations focuses mainly on extrapolating past mortality trends and summarizing these trends by one or more common latent factors. This article proposes a multipopulation stochastic mortality model that uses the explanatory power of economic growth. In particular, we extend the Li and Lee model (Li and Lee 2005) by including economic growth, represented by the real gross domestic product (GDP) per capita, to capture the common mortality trend for a group of populations with similar socioeconomic conditions. We find that our proposed model provides a better in-sample fit and an out-of-sample forecast performance. Moreover, it generates lower (higher) forecasted period life expectancy for countries with high (low) GDP per capita than the Li and Lee model.

  6. New approaches to the economic evaluation of fusion research

    International Nuclear Information System (INIS)

    Hazelrigg, G.A.; Lietzke, K.R.

    1978-01-01

    The economic evaluation of fusion research to date has focussed on the benefits of essentially unlimited energy for future generations. In this paper it is shown that energy research in general, and fusion research in particular, also provides benefits in the short term, benefitting us today as well as future generations. Short-term benefits are the result of two distinct aspects of fusion research. First, fusion research provides information for decision making on both the continuing fusion research efforts and on other energy research programs. Second, fusion research provides an expectation of a future energy source thereby promoting accelerated consumption of existing fossil fuels today. Both short-term benefits can be quantitatively evaluated and both are quite substantial. Together, these short-term benefits form the primary economic rationale for fusion research

  7. Energy and economic growth in the USA: a multivariate approach

    International Nuclear Information System (INIS)

    Stern, D.I.

    1993-01-01

    This paper examines the casual relationship between Gross Domestic Product and energy use for the period 1947-90 in the United States of America. The relationship between energy use and economic growth has been examined by both biophysical and neoclassical economists. In particular, several studies have tested for the presence of a causal relationships (in the Granger sense) between energy use and economic growth. However, these tests do not allow a direct test of the relative explanatory powers of the neoclassical and biophysical models. A multivariate adaptation of the test-vector autoregression (VAR) does allow such a test. A VAR of GDP, energy use, capital stock and employment is estimated and Granger tests for causal relationships between the variables are carried out. Although there is no evidence that gross energy use Granger causes GDP, a measure of final energy use adjusted for changing fuel composition does Granger cause GDP. (author)

  8. New approaches to business cycle theory in current economic science

    Directory of Open Access Journals (Sweden)

    Monica DOBRESCU

    2012-07-01

    Full Text Available In modern economies, current research generally acknowledges that the central issues in macroeconomics are essentially the same as those identified by Keynes in the General Theory of Employment, Interest and Money. One way or the other, economists are trying to address the same macroeconomic issues that they did seven decades ago: How can we account for the different growth rates and various fluctuations observed in national economies? Which are the economic policies most suitable to solve the issues of growth and cyclic behavior? Both the new classicals and the new Keynesians have made considerable progress within their research paradigms: to explain economic fluctuations, the new classicals focus on technological perturbations, the intertemporal substitution of leisure and real business cycles; on the other hand, the new Keynesians speak in terms of monopolistic competition, menu costs or efficiency wages. On the whole, the new classicals believe that the business cycle can best be understood within the market-clearing model, whereas the new keynesians believe that business fluctuations are due to certain market failures of various sorts.The present paper focuses on the main directions of research of the new classical school on the business cycle, given that the theoretical progress in this field has been significant and relevant for economic policy during the past four decades.

  9. Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population

    OpenAIRE

    He, Qingfang; Fan, Chunhong; Yu, Min; Wallar, Gina; Zhang, Zuo-Feng; Wang, Lixin; Zhang, Xinwei; Hu, Ruying

    2013-01-01

    Background The present study was designed to explore the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D, rs4646994) polymorphism, plasma ACE activity, and circulating ACE mRNA expression with essential hypertension (EH) in a Chinese population. In addition, a new detection method for circulating ACE mRNA expression was explored. Methods The research was approved by the ethics committee of Zhejiang Provincial Center for Disease Prevention and Control. Written i...

  10. Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population

    Science.gov (United States)

    He, Qingfang; Fan, Chunhong; Yu, Min; Wallar, Gina; Zhang, Zuo-Feng; Wang, Lixin; Zhang, Xinwei; Hu, Ruying

    2013-01-01

    Background The present study was designed to explore the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D, rs4646994) polymorphism, plasma ACE activity, and circulating ACE mRNA expression with essential hypertension (EH) in a Chinese population. In addition, a new detection method for circulating ACE mRNA expression was explored. Methods The research was approved by the ethics committee of Zhejiang Provincial Center for Disease Prevention and Control. Written informed consent was obtained prior to the investigation. 221 hypertensives (cases) and 221 normotensives (controls) were interviewed, subjected to a physical examination, and provided blood for biochemical and genetic tests. The ACE mRNA expression was analyzed by real time fluorescent quantitative Reverse Transcription PCR (FQ-RT-PCR). We performed logistic regression to assess associations of ACE I/D genotypes, ACE activity, and ACE mRNA expression levels with hypertension. Results The results of the multivariate logistic regression analysis showed that the additive model (ID, DD versus II) of the ACE genotype revealed an association with hypertension with adjusted OR of 1.43(95% CI: 1.04-1.97), and ACE ID genotype with adjusted OR of 1.72(95% CI: 1.01-2.92), DD genotype with adjusted OR of 1.94(95% CI: 1.01-3.73), respectively. In addition, our data also indicate that plasma ACE activity (adjusted OR was 1.13(95% CI: 1.08-1.18)) was significantly related to hypertension. However, the plasma ACE mRNA expressions were not different between the cases and controls. Conclusion ACE I/D polymorphism and ACE activity revealed significant influence on hypertension, while circulating ACE mRNA expression was not important factors associated with hypertension in this Chinese population. The detection of circulating ACE mRNA expression by FQ-RT-PCR might be a useful method for early screening and monitoring of EH. PMID:24098401

  11. Tax Compliance Models: From Economic to Behavioral Approaches

    Directory of Open Access Journals (Sweden)

    Larissa Margareta BĂTRÂNCEA

    2012-06-01

    Full Text Available The paper reviews the models of tax compliance with an emphasis on economic and behavioral perspectives. Although the standard tax evasion model of Allingham and Sandmo and other similar economic models capture some important aspects of tax compliance (i.e., taxpayers’ response to increases in tax rate, audit probability, penalty rate they do not suffice the need for an accurate prediction of taxpayers’ behavior. The reason is that they do not offer a comprehensive perspective on the sociological and psychological factors which shape compliance (i.e., attitudes, beliefs, norms, perceptions, motivations. Therefore, the researchers have considered examining taxpayers’ inner motivations, beliefs, perceptions, attitudes in order to accurately predict taxpayers’ behavior. As a response to their quest, behavioral models of tax compliance have emerged. Among the sociological and psychological factors which shape tax compliance, the ‘slippery slope’ framework singles out trust in authorities and the perception of the power of authorities. The aim of the paper is to contribute to the understanding of the reasons for which there is a need for a tax compliance model which incorporates both economic and behavioral features and why governments and tax authorities should consider these models when designing fiscal policies.

  12. Economic analysis of Marine Protected Areas: Bioeconomic Modeling and Economic Valuation Approaches

    OpenAIRE

    Bui, Bich Xuan

    2017-01-01

    The papers 2 and 3 of this thesis are not available in Munin. Paper 2: Xuan, B. B., Sandorf, E. D., Aanesen, M.: “Informing Management Strategies for a Reserve: Results from a Discrete Choice Experiment Survey”. (Manuscript). Paper 3: Xuan, B. B.: “Extractive and Non-extractive Values of a Marine Protected Area: A Bio-economic Model Application". (Manuscript). Marine protected areas (MPAs) are often established for conservation objectives. Benefits provided by MPAs exceed pure biod...

  13. Climate change and economic growth: a heterogeneous panel data approach.

    Science.gov (United States)

    Sequeira, Tiago Neves; Santos, Marcelo Serra; Magalhães, Manuela

    2018-05-31

    Climate change is a global phenomenon. Its impact on economic growth must therefore be analyzed in accordance with its (time-varying) common effects. We present an econometric analysis that evaluates this effect taking into account its global nature. Contrary to previous evidence that ignores the global effects, we obtain that the rising temperature has not decreased growth in real GDP per capita in the second half of the twentieth century for the world countries. However, we obtain a negative effect of rising temperatures and a positive effect of rising precipitation in poor countries. This positive effect of rising precipitation is also confirmed for hot and temperate countries.

  14. Approaches to defining «financial potential» concept as of economic analysis object

    Directory of Open Access Journals (Sweden)

    O.M. Dzyubenkо

    2017-12-01

    Full Text Available The research analyzes the works of scientists who studied the issues of financial potential as an economic category. Due to analyzing the approaches of the scientists to the concept of "financial potential" the author identifies six approaches to the interpretation of its essence, they are: the totality of the enterprise financial resources, the sources of the enterprise economic activity financing, the enterprise economic activity development, the enterprise financial indicators, the system of enterprise financial management, the enterprise efficiency characteristics. It is established that the financial potential is the multifaceted category that characterizes the financial and economic activity of enterprises. The author's definition of the financial potential in the context of its place in the objects of economic analysis is proposed. It is established that the financial potential is the object of the enterprise economic activity management and is the subject to analytical assessments for establishing its state and directions of development.

  15. An approach to evaluating the economic impact of emissions trading

    International Nuclear Information System (INIS)

    Lieu, S.; Johnson, S.L.; Dabirian, S.

    1993-01-01

    The command-and-control system to air quality controls is a mixture of technology-forcing standards for existing sources and offset for new sources. More stringent controls are required to achieve the ambient air quality standards in non-attainment urban areas which have been conformed with burgeoning economic growth. Due to the economy of scale and locale of polluting sources, some sources can implement these controls in a more cost-effective manner than others. In order to minimize the control costs of regulated sources, trading of emissions has been stipulated and has occurred among power plants to curb acid rain at the national level. Southern California is currently embarking on the trading of oxides of nitrogen, reactive organic compounds, and oxides of sulfur among existing and new stationary sources. New economic opportunities for entrepreneurs with advances control technology will arise under emissions trading. Trading will also result in the redistribution of emissions geographically and across industries. Through the linkage of a linear-programming trading model, a regional econometric model, and an urban airshed model, the impact of trading on the Southern California economy can thus be examined. This paper describes a framework which can be used to compare and contrast RECLAIM with the command-and-control system; and discusses a few issues which may arise in a trading market and how these issues can be dealt with are also examined

  16. The Keynesian Approach of Business Cycle and Economic Crises and its Criticism

    Directory of Open Access Journals (Sweden)

    Ionela Bălțătescu

    2009-10-01

    Full Text Available The main purpose of this article is to briefly present the Keynesian explanation of business cycle, economic fluctuation and crises, and also the solutions proposed from Keynesian perspective to the economic problems that characterize the bust phases of the business cycles (unemployment, recessions. In the fourth section of the article some criticisms of the Keynesian theoretical approach of the economic crises are considered and summarized.

  17. Lunar COTS: An Economical and Sustainable Approach to Reaching Mars

    Science.gov (United States)

    Zuniga, Allison F.; Rasky, Daniel; Pittman, Robert B.; Zapata, Edgar; Lepsch, Roger

    2015-01-01

    The NASA COTS (Commercial Orbital Transportation Services) Program was a very successful program that developed and demonstrated cost-effective development and acquisition of commercial cargo transportation services to the International Space Station (ISS). The COTS acquisition strategy utilized a newer model than normally accepted in traditional procurement practices. This new model used Space Act Agreements where NASA entered into partnerships with industry to jointly share cost, development and operational risks to demonstrate new capabilities for mutual benefit. This model proved to be very beneficial to both NASA and its industry partners as NASA saved significantly in development and operational costs while industry partners successfully expanded their market share of the global launch transportation business. The authors, who contributed to the development of the COTS model, would like to extend this model to a lunar commercial services program that will push development of technologies and capabilities that will serve a Mars architecture and lead to an economical and sustainable pathway to transporting humans to Mars. Over the past few decades, several architectures for the Moon and Mars have been proposed and studied but ultimately halted or not even started due to the projected costs significantly exceeding NASA's budgets. Therefore a new strategy is needed that will fit within NASA's projected budgets and takes advantage of the US commercial industry along with its creative and entrepreneurial attributes. The authors propose a new COTS-like program to enter into partnerships with industry to demonstrate cost-effective, cis-lunar commercial services, such as lunar transportation, lunar ISRU operations, and cis-lunar propellant depots that can enable an economical and sustainable Mars architecture. Similar to the original COTS program, the goals of the proposed program, being notionally referred to as Lunar Commercial Orbital Transfer Services (LCOTS

  18. An approach for economic analysis of intermodal transportation.

    Science.gov (United States)

    Sahin, Bahri; Yilmaz, Huseyin; Ust, Yasin; Guneri, Ali Fuat; Gulsun, Bahadir; Turan, Eda

    2014-01-01

    A different intermodal transportation model based on cost analysis considering technical, economical, and operational parameters is presented. The model consists of such intermodal modes as sea-road, sea-railway, road-railway, and multimode of sea-road-railway. A case study of cargo transportation has been carried out by using the suggested model. Then, the single road transportation mode has been compared to intermodal modes in terms of transportation costs. This comparison takes into account the external costs of intermodal transportation. The research reveals that, in the short distance transportation, single transportation modes always tend to be advantageous. As the transportation distance gets longer, intermodal transportation advantages begin to be effective on the costs. In addition, the proposed method in this study leads to determining the fleet size and capacity for transportation and the appropriate transportation mode.

  19. An Approach for Economic Analysis of Intermodal Transportation

    Science.gov (United States)

    Sahin, Bahri; Ust, Yasin; Guneri, Ali Fuat; Gulsun, Bahadir; Turan, Eda

    2014-01-01

    A different intermodal transportation model based on cost analysis considering technical, economical, and operational parameters is presented. The model consists of such intermodal modes as sea-road, sea-railway, road-railway, and multimode of sea-road-railway. A case study of cargo transportation has been carried out by using the suggested model. Then, the single road transportation mode has been compared to intermodal modes in terms of transportation costs. This comparison takes into account the external costs of intermodal transportation. The research reveals that, in the short distance transportation, single transportation modes always tend to be advantageous. As the transportation distance gets longer, intermodal transportation advantages begin to be effective on the costs. In addition, the proposed method in this study leads to determining the fleet size and capacity for transportation and the appropriate transportation mode. PMID:25152919

  20. Approaches to economic analysis of profitability of forestry enterprises

    Directory of Open Access Journals (Sweden)

    O.M. Dzyubenko

    2018-03-01

    Full Text Available The article substantiates the directions of adaptation of existing analytical procedures for assessing the profitability to specific activities of forestry enterprises, which is an integral part of evaluating financial potential of enterprises of the investigated branch. In particular, the author identifies the following analytical procedures that make it possible to assess the performance of forestry enterprises and determine its financial potential: the return on equity (assets on net profit, the return on equity, the return on assets, the return on sales of profits from operating activities, the profitability of sold products at net profit, reinvestment factor, the economic growth sustainability ratio, the period of payback capital, the payback period of equity capital. On the basis of these indicators, the current state of profitability of forestry enterprises was substantiated and their critical points were determined.

  1. Approaches based on behavioral economics could help nudge patients and providers toward lower health spending growth.

    Science.gov (United States)

    King, Dominic; Greaves, Felix; Vlaev, Ivo; Darzi, Ara

    2013-04-01

    Policies that change the environment or context in which decisions are made and "nudge" people toward particular choices have been relatively ignored in health care. This article examines the role that approaches based on behavioral economics could play in "nudging" providers and patients in ways that could slow health care spending growth. The basic insight of behavioral economics is that behavior is guided by the very fallible human brain and greatly influenced by the environment or context in which choices are made. In policy arenas such as pensions and personal savings, approaches based on behavioral economics have provided notable results. In health care, such approaches have been used successfully but in limited ways, as in the use of surgical checklists that have increased patient safety and reduced costs. With health care spending climbing at unsustainable rates, we review the role that approaches based on behavioral economics could play in offering policy makers a potential set of new tools to slow spending growth.

  2. Nutrition economics: an innovative approach to informed public health management.

    Science.gov (United States)

    Nuijten, Mark; Lenoir-Wijnkoop, Irene

    2011-09-01

    The role of nutrition to optimize the use of scarce resources through its linkage with health and welfare should be considered of interest by healthcare decision makers. A favorable impact of food on non-communicable disorders and general health status will improve healthcare expenditure and quality of life.In health economics, an analysis of the costs and effects of a healthcare technology by means of a cost-effectiveness analysis has become an established tool. Projections about the effectiveness and expected costs of an intervention can be modeled using realistic and explicit assumptions based on outcomes from randomized clinical studies. However, the use of health economic techniques to assess costs and effects is not solely restricted to classic healthcare products such as medicines. To illustrate this we used two published cost-effectiveness studies, which consider respectively a preventive treatment against severe respiratory syncytial virus infection in children at high risk of hospitalization and the use of prebiotics for the primary prevention of atopic dermatitis.These examples illustrate that there is a parallel between the methodologies for extrapolation of intermediate outcomes to long-term outcomes between a cost-effectiveness analysis for pharmaceutical or nutrition, as long as the clinical evidence for nutrition fulfils the requirements for pharmaceuticals. Another requirement is that there is clinical widely accepted evidence that matches a comparable level of epidemiological observations about the link between short-term and long-term outcomes.Better understanding of how nutritional status and behavior may interplay with the socioeconomic environment will ultimately contribute to preserving the sustainability of healthcare provisions. Copyright © 2011 Elsevier B.V. All rights reserved.

  3. The economic importance of meetings and conferences: A satellite account approach

    OpenAIRE

    Jones, C; Li, S

    2015-01-01

    Meetings and conventions (MICE) visitation is often considered an important element of the travel economy, and destinations target such activities to encourage their growth. It has hitherto been difficult to measure the economic significance of such activity at any spatial scale. Latterly, the development and codification of tourism satellite account (TSA) approaches to the economic measurement of tourism offers an opportunity to develop a parallel approach to understanding the MICE economy. ...

  4. A qualitative approach to economic-environmental dispatch

    International Nuclear Information System (INIS)

    Gjengedal, T.; Hansen, O.; Johansen, S.

    1992-01-01

    This paper describes the principles, and suggests a methodology for expanding the dispatch of electrical power production systems for involving a pure minimum cost dispatch, to also include environmental objectives. The approach is qualitative in that no attempt is made as to assign a specific monetary value to environmental impacts, but rather maintaining the physical value of the impact through the decision process. However, the initial relative weights assigned to environmental impacts in the methodology are based on the many recent attempts to monetize environmental damages. The main contribution of the approach is to analyze how dispatch changes as a function of the total environmental weight, and as a function of the relative weighing of individual environmental insults, e.g., SO 2 , NO x and CO 2 . The methodology is illustrated with a sample production system involving environmental coast estimates from major US studies

  5. Cow-specific treatment of clinical mastitis: an economic approach.

    Science.gov (United States)

    Steeneveld, W; van Werven, T; Barkema, H W; Hogeveen, H

    2011-01-01

    Under Dutch circumstances, most clinical mastitis (CM) cases of cows on dairy farms are treated with a standard intramammary antimicrobial treatment. Several antimicrobial treatments are available for CM, differing in antimicrobial compound, route of application, duration, and cost. Because cow factors (e.g., parity, stage of lactation, and somatic cell count history) and the causal pathogen influence the probability of cure, cow-specific treatment of CM is often recommended. The objective of this study was to determine if cow-specific treatment of CM is economically beneficial. Using a stochastic Monte Carlo simulation model, 20,000 CM cases were simulated. These CM cases were caused by Streptococcus uberis and Streptococcus dysgalactiae (40%), Staphylococcus aureus (30%), or Escherichia coli (30%). For each simulated CM case, the consequences of using different antimicrobial treatment regimens (standard 3-d intramammary, extended 5-d intramammary, combination 3-d intramammary+systemic, combination 3-d intramammary+systemic+1-d nonsteroidal antiinflammatory drugs, and combination extended 5-d intramammary+systemic) were simulated simultaneously. Finally, total costs of the 5 antimicrobial treatment regimens were compared. Some inputs for the model were based on literature information and assumptions made by the authors were used if no information was available. Bacteriological cure for each individual cow depended on the antimicrobial treatment regimen, the causal pathogen, and the cow factors parity, stage of lactation, somatic cell count history, CM history, and whether the cow was systemically ill. Total costs for each case depended on treatment costs for the initial CM case (including costs for antibiotics, milk withdrawal, and labor), treatment costs for follow-up CM cases, costs for milk production losses, and costs for culling. Average total costs for CM using the 5 treatments were (US) $224, $247, $253, $260, and $275, respectively. Average probabilities

  6. Recycling and Disposal of Lithium Battery: Economic and Environmental Approach

    Directory of Open Access Journals (Sweden)

    Ataur Rahman

    2017-12-01

    Full Text Available The adoption of Lithium-ion battery technology for Electric Vehicle/Hybrid electric vehicle has received attention worldwide recently. The price of cobalt (Co and lithium (Li has increased due to the production of EV/HEV.  The used lithium battery is the valuable source of active metals (Co, Li, and Al and the optimal way of extract these metals from this waste is still studied. The focus of this paper is to recovering active metals by using a hydro-metallurgical method in laboratory scale with 48.8 Wh battery to reveal the economic and environment benefits. Calcination on extracted active metals as pre-thermal treatment has been conducted at 700°C to remove the organic compounds from the surface of active metals. The experiment has been conducted and the result shows that the recovery of active metals (cathode is 41% of cell cathode and an anode is 8.5% of the cell anode materials, which are 48.8% and 23.4% of the cathode and anode cell material price, respectively. By recycling the battery active metals about 47.34%, the emission can be reduced by 47.61% for battery metal production and 60.7% for transportation of used battery disposal. The total emission can be controlled about 52.85% by recycling the active metals on battery production.

  7. Baseline development, economic risk, and schedule risk: An integrated approach

    International Nuclear Information System (INIS)

    Tonkinson, J.A.

    1994-01-01

    The economic and schedule risks of Environmental Restoration (ER) projects are commonly analyzed toward the end of the baseline development process. Risk analysis is usually performed as the final element of the scheduling or estimating processes for the purpose of establishing cost and schedule contingency. However, there is an opportunity for earlier assessment of risks, during development of the technical scope and Work Breakdown Structure (WBS). Integrating the processes of risk management and baselining provides for early incorporation of feedback regarding schedule and cost risk into the proposed scope of work. Much of the information necessary to perform risk analysis becomes available during development of the technical baseline, as the scope of work and WBS are being defined. The analysis of risk can actually be initiated early on during development of the technical baseline and continue throughout development of the complete project baseline. Indeed, best business practices suggest that information crucial to the success of a project be analyzed and incorporated into project planning as soon as it is available and usable

  8. Financial fluctuations anchored to economic fundamentals: A mesoscopic network approach.

    Science.gov (United States)

    Sharma, Kiran; Gopalakrishnan, Balagopal; Chakrabarti, Anindya S; Chakraborti, Anirban

    2017-08-14

    We demonstrate the existence of an empirical linkage between nominal financial networks and the underlying economic fundamentals, across countries. We construct the nominal return correlation networks from daily data to encapsulate sector-level dynamics and infer the relative importance of the sectors in the nominal network through measures of centrality and clustering algorithms. Eigenvector centrality robustly identifies the backbone of the minimum spanning tree defined on the return networks as well as the primary cluster in the multidimensional scaling map. We show that the sectors that are relatively large in size, defined with three metrics, viz., market capitalization, revenue and number of employees, constitute the core of the return networks, whereas the periphery is mostly populated by relatively smaller sectors. Therefore, sector-level nominal return dynamics are anchored to the real size effect, which ultimately shapes the optimal portfolios for risk management. Our results are reasonably robust across 27 countries of varying degrees of prosperity and across periods of market turbulence (2008-09) as well as periods of relative calmness (2012-13 and 2015-16).

  9. The improvement of approaches to assessment of the financial condition of economic entities

    Directory of Open Access Journals (Sweden)

    Senko A.E.

    2017-05-01

    Full Text Available according to the author, the lack of unified approaches to the calculation of financial indicators, the multiple interpretations of their meanings ​​and the imperfection of information support of financial analysis hamper the effectiveness of economic entities operating under market principles. The existing approach to determining the financial condition of an enterprise does not always give the required qualitative result of an evaluation of its financial and economic activities. While analyzing the financial status of economic entities, it would be useful to take into account their industry particularities, size and organizational structure, development strategy and competitiveness in the market for goods and services.

  10. Bounds test approach to cointegration and causality between nuclear energy consumption and economic growth in India

    International Nuclear Information System (INIS)

    Wolde-Rufael, Yemane

    2010-01-01

    This paper attempts to examine the dynamic relationship between economic growth, nuclear energy consumption, labor and capital for India for the period 1969-2006. Applying the bounds test approach to cointegration developed by we find that there was a short- and a long-run relationship between nuclear energy consumption and economic growth. Using four long-run estimators we also found that nuclear energy consumption has a positive and a statistically significant impact on India's economic growth. Further, applying the approach to Granger causality and the variance decomposition approach developed by , we found a positive and a significant uni-directional causality running from nuclear energy consumption to economic growth without feedback. This implies that economic growth in India is dependent on nuclear energy consumption where a decrease in nuclear energy consumption may lead to a decrease in real income. For a fast growing energy-dependent economy this may have far-reaching implications for economic growth. India's economic growth can be frustrated if energy conservation measures are undertaken without due regard to the negative impact they have on economic growth.

  11. Innovative development of universities: organizational and economic approach

    Directory of Open Access Journals (Sweden)

    Belokrylova Olga, S.

    2015-06-01

    Full Text Available It is shown that the innovative activity of universities in Russia is always accompanied by the organizational changes carried out in the framework of the concept of stage-by-stage approach – a combination of natural and subjectively rational principle and based on intra-organizational integration of all subjects of University ethos for joint decisions in the field of organizational change. The authors analyze the mission transformation of universities determined by formation of information society which now is including not only development of the human capital, but also creation of knowledge as the competitive product possessing the essential production and social importance.

  12. Externalities of fuel cycles 'ExternE' project. Economic valuation. Economical valuation: An impact pathway approach

    International Nuclear Information System (INIS)

    Markandya, A.

    1994-01-01

    The EC/US study of the external costs of fuel cycles is designed to trace through all the environmental impacts arising from the use of a particular fuel, from the 'cradle' to the 'grave'; to quantify these impacts as far as possible (giving priority to those that are the considered the most important) and to value the damages arising from them in money terms as far as possible (again keeping to the priority listing established by the physical quantification). The fuel cycle has been identified as consisting of the following elements: activities -> emissions/burdens; emissions/burdens -> physical environmental impacts; physical impacts -> external environmental impacts; external impacts -> costs of these impacts. The activities consist of all the operations that are carried out in connection with the extraction transportation, use in electricity generation and finally disposal of the fuel. The emissions or burdens arising from the cycle result in physical impacts, which in turn imply certain environmental impacts. An illustration of a typical fuel cycle (coal) audits environmental impacts is given in Figures. The work of the fuels cycle study teams is to complete the valuation of the shaded areas but giving priority to those impacts that are likely to be quantitatively important. .Each fuel cycle is evaluated in a location-specific context, so that it refers to the impacts arising from the use of coal, or gas or whatever fuel is being considered at an actual plant that is operating. The purpose of this report on economic valuation is to: (a) examine the literature or economic valuation of environmental externalities in Europe; (b) assess its relevance to the fuel cycle study and (c) make recommendations on how the detailed analysis of the individual fuel cycles should use the economic valuation. It is important to recognize that the report is not a complete survey of all the research ever done on environmental valuation. Although as complete a survey of all the

  13. Economic implications of Japan's aging population: a macro-economic demographic modeling approach.

    Science.gov (United States)

    Ogawa, N

    1982-01-01

    This paper utilizes a macroeconomic demographic model to analyze the probable impact of population aging on various public programs in Japan. Rapid fertility decline aided by mortality decline has caused the proportion of the Japanese population aged 65 and over to increase from 4.9% in 1950 to 9.0% in 1980. A population projection based on the 1975 population census assumes a recovery of fertility from a total fertility rate (TFR) of 1.9 in 1976 to 2.16 in 1980 and a gradual decline to 2.1 by 1987, while an alternative projection assumes a continuing fertility decline to a TFR of 1.65 in 2025. According to these assumptions, in 2025 18.12% to 21.29% of the total population would be aged 65 or over and 38.66% to 43.80% of the working age population would be aged 45-64. A macroeconomic neoclassical growth model with some Keynesian features was formulated to evaluate the future impact of population aging on social security programs. Population changes are transmitted to economic variables in the model through the supply of labor, level of savings, public health care plans, and old-age pension schemes. The simulation experiments included the 2 population projections and 2 alternative production functions, 1 with the quality of labor incorporated and 1 without. The results indicated that, regardless of the population projection and production function used, the growth of the economy is likely to slow to 1 or 0% in the beginning of the next century due to decreased growth of the labor force and a change in its quality due to age-compositional variations. Public health insurance schemes and pension plans will require increasing financial resources as a result of accelerated population aging; depending on the choice of benefit levels, the proportion of national income allocated to them is expected to range from 14%-40% in the year 2010. Per capita gross national product will continue to grow despite decreased economic growth, but savings might be adversely affected if the

  14. The economics of window selection: An incremental approach

    International Nuclear Information System (INIS)

    Dixon, W.T.

    1993-01-01

    The options available to Energy Service Companies when improving the energy performance of an existing building are often driven by short-term payback cycles. The value of a measure is based on how quickly it pays for itself. The more quickly the energy savings created by the measure exceed the cost of purchasing and installing the measure, the more comfortable the engineer feels recommending that improvement. In the best cases, the short-term approach will quickly retire the debts associated with a particular retrofit and provide a dependable, albeit limited net savings stream for the property owner. The engineer has obtained energy savings for his client. The problem with this short-term approach is that it automatically eliminates other conservation measures which, over longer time horizons, could add far more value for the customer. The installation of new, extremely energy efficient replacement windows is a case in point. During preliminary discussions with our clients, (typically Public Housing Authorities or owners of subsidized, multi-family housing), the conversation eventually turns to the issue of replacement windows. The perception is that new windows are a luxury. The decision to install new windows is driven by maintenance costs and, in some cases, resident complaints over operability or draftiness associated with the existing windows. Typically the windows are not handled as part of the mainstream energy conservation program. If the client has already installed new windows, he probably based his selection on the low bidder of a unit that has marginal thermal performance. Every property has a budget and compromises must often be made to meet budgets. The purchaser may have not gotten the Cadillac of windows, but at least he got a good deal on the window that he did buy. His maintenance problems have been solved for the near term and resident complaints have gone down, for now

  15. The Atmospheric Chemistry Experiment (ACE): Mission Overview

    Science.gov (United States)

    Bernath, P. F.; Boone, C.; Walker, K.; McLeod, S.; Nassar, R.

    2003-12-01

    The ACE mission goals are: (1) to measure and to understand the chemical and dynamical processes that control the distribution of ozone in the upper troposphere and stratosphere, with a particular emphasis on the Arctic region; (2) to explore the relationship between atmospheric chemistry and climate change; (3) to study the effects of biomass burning in the free troposphere; (4) to measure aerosol number density, size distribution and composition in order to reduce the uncertainties in their effects on the global energy balance. ACE will make a comprehensive set of simultaneous measurements of trace gases, thin clouds, aerosols, and temperature by solar occultation from a satellite in low earth orbit. A high inclination (74 degrees) low earth orbit (650 km) gives ACE coverage of tropical, mid-latitudes and polar regions. The solar occultation advantages are high sensitivity and self-calibration. A high-resolution (0.02 cm-1) infrared Fourier Transform Spectrometer (FTS) operating from 2 to 13 microns (750-4100 cm-1) will measure the vertical distribution of trace gases, and the meteorological variables of temperature and pressure. The ACE concept is derived from the now-retired ATMOS FTS instrument, which flew on the Space Shuttle in 1985, 1992, 1993, 1994. Climate-chemistry coupling may lead to the formation of an Arctic ozone hole. ACE will provide high quality data to confront these model predictions and will monitor polar chemistry as chlorine levels decline. The ACE-FTS can measure water vapor and HDO in the tropical tropopause region to study dehydration and strat-trop exchange. The molecular signatures of massive forest fires will evident in the ACE infrared spectra. The CO2 in our spectra can be used to either retrieve atmospheric pressure or (if the instrument pointing knowledge proves to be satisfactory) for an independent retrieval of a CO2 profile for carbon cycle science. Aerosols and clouds will be monitored using the extinction of solar radiation at

  16. A CDT-Based Heuristic Zone Design Approach for Economic Census Investigators

    Directory of Open Access Journals (Sweden)

    Changixu Cheng

    2015-01-01

    Full Text Available This paper addresses a special zone design problem for economic census investigators that is motivated by a real-world application. This paper presented a heuristic multikernel growth approach via Constrained Delaunay Triangulation (CDT. This approach not only solved the barriers problem but also dealt with the polygon data in zoning procedure. In addition, it uses a new heuristic method to speed up the zoning process greatly on the premise of the required quality of zoning. At last, two special instances for economic census were performed, highlighting the performance of this approach.

  17. EPR design: A combined approach on safety and economic competitiveness

    International Nuclear Information System (INIS)

    Griedl, R.; Sturm, J.; Degrave, C.; Kappler, F.; Martin-Onraet, M.

    2001-01-01

    Starting in 1991, the French and German cooperation led to common work based on the experience of the two designers FRAMATOME and SIEMENS KWU with all their know how, the most important utilities in France and Germany operating NPP and the technical supports of the Licensing Authorities GRS and IPSN. The conclusion of that work was the issue in November 1997 and February 1999 respectively of two Basic Design reports for a European Pressurized Reactor (EPR) with a power of 4250 MWth and 4900 MWth. The Basic Design approach was led under two key items: Enhancement of the overall safety level by implementation of design measures to: make the plant less dependant to common cause failures; practically eliminate all high pressure core melt sequences which could lead to important radioactive releases to the environment; implement specific systems to face severe accident situation with low-pressure core melt. Use of the many years of experiences in two different nuclear designs is to reach an overall availability figure over 91%, partly due to design improvements on the safety level. With such an objective, demonstrated by feedback of experience on already operating plants, the EPR project can be proposed as a competitive alternative to the most recent fossil plants. (author)

  18. Foreseeable cost and economic impacts of the approach proposed

    International Nuclear Information System (INIS)

    Broeskamp, H.; Brammer, K.-J.; Schlombs, H.

    2003-01-01

    Under the German Atomic Energy Act, the federal government is responsible for the construction of repositories for radioactive waste. Steps to this end were initiated early on when the first nuclear power plants were commissioned in the 1960s. They resulted, among other approaches, in the decisions and site selection procedures for the Gorleben salt dome and the former Konrad iron ore mine as potential repository sites in the 1970s and 1980s. In 2000, the federal government imposed a moratorium of three up to a maximum of ten years on further exploration activities at Gorleben in order to dispel doubts held by the German Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety (BMU). A positive plans approval decision on Konrad was publicized in May 2002. Emplacement could begin roughly in 2010-2012, once legal certainty will have been ensured. In February 1999, BMU appointed a working party to establish site selection procedures for repositories (AkEnd) which was to develop a transparent procedure of finding and selecting sites for the final storage of all kinds of radioactive waste in Germany. The procedure finally proposed by AkEnd implies considerable uncertainty, inter alia, about its legal implementability, the time required, and funding. For the Gorleben salt dome, for instance, additional exploration and procedures alone could give rise to extra costs of euro 3-5 billion, compared to merely continuing project activities. Similar extra costs are likely to arise especially to the government if emplacement in Konrad were to be delayed. Under aspects of technical safety, the speediest possible emplacement of all types of waste in deep geologic formations is preferable to all other options. Hence, further exploration of Gorleben should be completed quickly, and the Konrad project should be implemented, after due consideration of all factors. (orig.) [de

  19. Economics.

    Science.gov (United States)

    Palley, Paul D; Parcero, Miriam E

    2016-10-01

    A review of literature in the calendar year 2015 dedicated to environmental policies and sustainable development, and economic policies. This review is divided into these sections: sustainable development, irrigation, ecosystems and water management, climate change and disaster risk management, economic growth, water supply policies, water consumption, water price regulation, and water price valuation.

  20. Identification and characterisation of the angiotensin converting enzyme-3 (ACE3 gene: a novel mammalian homologue of ACE

    Directory of Open Access Journals (Sweden)

    Phelan Anne

    2007-06-01

    Full Text Available Abstract Background Mammalian angiotensin converting enzyme (ACE plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2, has been identified in mammals. Results Here we report the identification and characterisation of the gene encoding a third homologue of ACE, termed ACE3, in several mammalian genomes. The ACE3 gene is located on the same chromosome downstream of the ACE gene. Multiple sequence alignment and molecular modelling have been employed to characterise the predicted ACE3 protein. In mouse, rat, cow and dog, the predicted protein has mutations in some of the critical residues involved in catalysis, including the catalytic Glu in the HEXXH zinc binding motif which is Gln, and ESTs or reverse-transcription PCR indicate that the gene is expressed. In humans, the predicted ACE3 protein has an intact HEXXH motif, but there are other deletions and insertions in the gene and no ESTs have been identified. Conclusion In the genomes of several mammalian species there is a gene that encodes a novel, single domain ACE-like protein, ACE3. In mouse, rat, cow and dog ACE3, the catalytic Glu is replaced by Gln in the putative zinc binding motif, indicating that in these species ACE3 would lack catalytic activity as a zinc metalloprotease. In humans, no evidence was found that the ACE3 gene is expressed and the presence of deletions and insertions in the sequence indicate that ACE3 is a pseudogene.

  1. Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes

    DEFF Research Database (Denmark)

    Johannesen, Jesper; Svensson, Jannet; Bergholdt, Regine

    2011-01-01

    High S-ACE levels have been shown to predispose to increased risk of hypoglycemia, however; some inconsistency relates to the risk of the ACE genotype. We investigated the association between S-ACE level at diagnosis and ACE genotype to long-term risk of severe hypoglycemia in more than 1000 chil...... children and adolescents with type 1 diabetes being part of the Danish Registry of Childhood diabetes over a 10-yr period....

  2. The Strategically Oriented Approach to Studying the Economic Sustainability of Enterprises

    Directory of Open Access Journals (Sweden)

    Ponomarenko Tеtyana V.

    2017-03-01

    Full Text Available The article presents the constructive consideration of modern approaches to the study of the essence of economic sustainability. It is noted that they are focused on sustainability as a status of the economic system. It is actualized that such an approach does not correspond to the system-synergetic methodology, according to which sustainability has a dualistic nature: as a status and as a property of the system to be stable. The key provisions of the traditional approach to understanding the essence of economic sustainability are systematized. Based on the productive synthesis of the system-synergetic methodology and modern achievements of the theory of strategic management, there formed the author’s conceptual approach that extends the traditional content of economic sustainability exclusively as a status. The proposed approach extends the temporal context of sustainability from the provision of a momentary state to the formation of the possibilities for the permanent functioning of an enterprise. It is argued that these opportunities are determined by the organizational ability of companies to realize their functional purpose. This changes the priority of the managerial focus: from orientation to providing material, financial and labor resources (the traditional approach to the accumulation of resources that can not be the subject of market-based sales transactions (the strategically oriented approach.

  3. Traditional vs. Modern Approaches in Business English Teaching in the Economic Field

    OpenAIRE

    Adriana Teodorescu

    2013-01-01

    This paper aims to examine different techniques and approaches used in teaching and learning business English in the economic field. Besides applying the already well-known methods used in second language acquisition, we also tried to incorporate computer-mediated communication into the communicative approach. At all times, the choice of the methods and approaches used in teaching business English has focused on our students' needs in their vocation or job. We worked with two groups of studen...

  4. Two approaches to meeting the economic challenge for advanced BWR designs

    International Nuclear Information System (INIS)

    Rao, A.S.; Sawyer, C.D.

    1997-01-01

    This paper presents the design overview and approach to addressing the aforementioned economic challenges for two Advanced BWR designs. The first plant is the ABWR and the second is the ESBWR. The ABWR relies on proven technology and components and an extensive infrastructure that has been built up over the last 20 years. Because it has proven and standards safety systems it has very limited uncertainty regarding licensing. Finally, it relies on the economies of scale and overall design flexibility to improve the overall economics of power generation. The ESBWR on the other hand has taken an innovative approach to reduce systems and components to simplify the overall plant to improve plant economics. The overall plant design is indeed simpler, but improved economics required reliance on some economies of scale also. This design embodied in the ESBWR, also has minimized the overall development cost by utilizing features and components from the ABWR and SBWR technology programs

  5. Technology Development for 3-D Wide Swath Imaging Supporting ACE

    Science.gov (United States)

    Racette, Paul; Heymsfield, Gerry; Li, Lihua; Mclinden, Matthew; Park, Richard; Cooley, Michael; Stenger, Pete; Hand, Thomas

    2014-01-01

    The National Academy of Sciences Decadal Survey (DS) Aerosol-Cloud-Ecosystems Mission (ACE) aims to advance our ability to observe and predict changes to the Earth's hydrological cycle and energy balance in response to climate forcing, especially those changes associated with the effects of aerosol on clouds and precipitation. ACE is focused on obtaining measurements to reduce the uncertainties in current climate models arising from the lack in understanding of aerosol-cloud interactions. As part of the mission instrument suite, a dual-frequency radar comprised of a fixed-beam 94 gigahertz (W-band) radar and a wide-swath 35 gigahertz (Ka-band) imaging radar has been recommended by the ACE Science Working Group.In our 2010 Instrument Incubator Program project, we've developed a radar architecture that addresses the challenge associated with achieving the measurement objectives through an innovative, shared aperture antenna that allows dual-frequency radar operation while achieving wide-swath (100 kilometers) imaging at Ka-band. The antenna system incorporates 2 key technologies; a) a novel dual-band reflectorreflectarray and b) a Ka-band Active Electronically Scanned Array (AESA) feed module. The dual-band antenna is comprised of a primary cylindrical reflectorreflectarray surface illuminated by a point-focus W-band feed (compatible with a quasi-optical beam waveguide feed, such as that employed on CloudSat); the Ka-band AESA line feed provides wide-swath across-track scanning. The benefits of this shared-aperture approach include significant reductions in ACE satellite payload size, weight, and cost, as compared to a two aperture approach. Four objectives were addressed in our project. The first entailed developing the tools for the analysis and design of reflectarray antennas, assessment of candidate reflectarray elements, and validation using test coupons. The second objective was to develop a full-scale aperture design utilizing the reflectarray surface and to

  6. Conceptual Approaches to the Development of Economic Systems in the Context of Globalization and Regionalization

    Directory of Open Access Journals (Sweden)

    D. I.

    2017-12-01

    Full Text Available Interactions of the national and the global in economic transformations occurring in open economic systems are substantiated. Conceptual approaches to the development of economic systems in the globalization and regionalization context are summed up. It is shown that globalization is a logical consequence of mutual influences and interactions of multiple local transformations in socio-economic systems of various levels, which planetary self-organization generates the new quality of the global economic development. It is concluded that globalization has controversial impact on the transformation capacities of national economic systems that have to operate in the unfavorable condition of the growing instability of the global economic system and rapid integration in the structures with already established economic relations. The heuristic and experimental nature of economic and institutional transformations in these countries is added by splits of national economic systems and disruptions of established production links; the outstripping liberalization of foreign economic relations, creating rather external than internal pressures on national manufacturers and making them less capable to adapt to the competitive environment; the accelerated liberalization of monetary and financial systems, opening up ways to reallocation of capital from the sluggish real sector to the more flexible sector of transactions with currencies and securities; the shrinking regulatory authorities of national governments with respect of trade, competition, tax policies or social welfare; the growing domination of TNC and outflow of productive resources from national economies, important for their self-development, thus making their economic systems structurally primitive; the sharp property differentiation within societies and the increasing shares of population with low incomes.

  7. THE MAIN APPROACHES TO THE DEFINITION OF ECONOMIC EFFICIENCY OF ENTERPRISES OF CONSTRUCTION INDUSTRY

    Directory of Open Access Journals (Sweden)

    A. V. Dolgova

    2015-01-01

    Full Text Available The problem of ambiguous interpretation of the category of "efficiency". Taking into account the fact that economic efficiency is quite complex and multifaceted category, coupled with the economic laws and applies to all activities of the enterprise this figure is one of the essential characteristics of the processes occurring in industrial organizations. The lack of a generally accepted view among domestic and foreign economists regarding the essential part of the index of efficiency of activity of the industrial enterprise leads to the impossibility of its use for the management of processes. In the conditions of market economy, the task of economic evaluation res ults of the economic entity remains an important element of the research aspects of the company. Each new refinement of recorded knowledge acts as a stimulus for the development of fundamental knowledge categories. One of the Central in the system of economic categories, in our opinion, is indicated for the effective functioning of the enterprise." Precise formulation of the conceptual framework, criteria-based composition have important theoretical value to justify the subject of any research conducted in the conditions of modern economic development of the global space. The definition of criteria and performance indicators, as well as developing sound economic policies of improving the economic mechanism of enterprise depend on a comprehensive study of the essence of economic efficiency of industrial enterprises of the industry. The article examines the main approaches to the definition of economic efficiency, as well as identify the degree of relation of the category of "efficiency" with other economic categories. The author suggested that the characteristics of the essence of economic efficiency, adequate to the task of functioning and development of enterprises in the construction industry.

  8. Methodical Approach to Diagnostics of Efficiency of Production Economic Activity of an Enterprise

    Directory of Open Access Journals (Sweden)

    Zhukov Andrii V.

    2014-03-01

    Full Text Available The article offers developments of a methodical approach to diagnostics of efficiency of production economic activity of an enterprise, which, unlike the existing ones, is realised through the following stages: analysis of the enterprise external environment; analysis of the enterprise internal environment; identification of components of efficiency of production economic activity for carrying out complex diagnostics by the following directions: efficiency of subsystems of the enterprise production economic activity, efficiency of use of separate types of resources and socio-economic efficiency; scorecard formation; study of tendencies of change of indicators; identification of cause-effect dependencies between the main components of efficiency for diagnosing reasons of its level; diagnosing deviations of indicator values from their optimal values; development of a managerial decision on preserving and increasing efficiency of production economic activity of the enterprise.

  9. The Causality between Government Expenditure and Economic Growth in Nigeria: A Toda-Yamamoto Approach

    Directory of Open Access Journals (Sweden)

    Michael Adebayo Ajayi

    2016-01-01

    Full Text Available The relationship between government expenditure and economic growth has been an issue of debate over the years. This study investigates the causality between government expenditure and economic growth in Nigeria between 1985 and 2014. Following the Toda-Yamamoto non-Granger causality testing approach, it finds that government expenditure and economic growth have no causal effect on each other. This offers evidence to invalidate Wagner’s law and the Keynesian proposition in Nigeria. This study recommends that government should strengthen its efforts to curtail corruption as well as introduce stricter checks and controls to reduce or eliminate the profligacy of public funds.

  10. The Methodical Approaches to the Research of Informatization of the Global Economic Development

    Directory of Open Access Journals (Sweden)

    Kazakova Nadezhda A.

    2018-03-01

    Full Text Available The article is aimed at researching the identification of global economic development informatization. The complex of issues connected with research of development of informatization of the world countries in the conditions of globalization is considered. The development of informatization in the global economic space, which facilitates opening of new markets for international trade enterprises, international transnational corporations and other organizations, which not only provide exports, but also create production capacities for local producers. The methodical approach which includes three stages together with formation of the input information on the status of informatization of the global economic development of the world countries has been proposed.

  11. Economics of Internet of Things (IoT): An Information Market Approach

    OpenAIRE

    Niyato, D.; Lu, X.; Wang, P.; Kim, D. I.; Han, Z.

    2015-01-01

    Internet of things (IoT) has been proposed to be a new paradigm of connecting devices and providing services to various applications, e.g., transportation, energy, smart city, and healthcare. In this paper, we focus on an important issue, i.e., economics of IoT, that can have a great impact to the success of IoT applications. In particular, we adopt and present the information economics approach with its applications in IoT. We first review existing economic models developed for IoT services....

  12. John Dewey’s theory of democracy and its links with the heterodox approach to economics.

    Directory of Open Access Journals (Sweden)

    Arturo Hermann

    2011-07-01

    Full Text Available John Dewey is one of the most significant figures in pragmatist philosophy, an approach which he systematically applied to the study of economic, social and cultural structure. In our work, we will focus on the main aspects of Dewey’s approach to the study of aspects that make up “human nature” and how do they interact with the characteristics of the cultural context. We will illustrate how the concepts elaborated by Dewey can contribute to the heterodox analysis of a host of economic and social issues. Dewey highlights the crucial role of public policies for facilitating the development of volunteer associations in all areas of the social structure. In the analysis of these aspects, Dewey’s key contribution lies in removing the concepts of democracy and participation from the limbo of abstraction in which they tended to be confined by previous approaches and connecting them to the evolution of economic and social forms.

  13. Comparison of methodological approaches to identify economic activity regularities in transition economy

    Directory of Open Access Journals (Sweden)

    Jitka Poměnková

    2011-01-01

    Full Text Available Presented paper focuses on consideration and evaluation of methodical approaches to analyze cyclical structure character of economic activity in transition economy. As a starting point, work in time domain is applied, which is followed in frequency domain approach. Both approaches are viewed from methodical as well as application point of view and their advantage and disadvantage are discussed. Consequently, time-frequency domain approach is added and applied on real data. On the basis of obtained results recommendation is formulated. All discussed methodical approaches are also considered from the perspective of capability to evaluate behaving of business cycle in time of global economic crisis before/after year 2008. The empirical part of the paper deals with data of gross domestic product in the Czech Republic in 1996/Q1–2010/Q2.

  14. PAPR reduction in FBMC using an ACE-based linear programming optimization

    Science.gov (United States)

    van der Neut, Nuan; Maharaj, Bodhaswar TJ; de Lange, Frederick; González, Gustavo J.; Gregorio, Fernando; Cousseau, Juan

    2014-12-01

    This paper presents four novel techniques for peak-to-average power ratio (PAPR) reduction in filter bank multicarrier (FBMC) modulation systems. The approach extends on current PAPR reduction active constellation extension (ACE) methods, as used in orthogonal frequency division multiplexing (OFDM), to an FBMC implementation as the main contribution. The four techniques introduced can be split up into two: linear programming optimization ACE-based techniques and smart gradient-project (SGP) ACE techniques. The linear programming (LP)-based techniques compensate for the symbol overlaps by utilizing a frame-based approach and provide a theoretical upper bound on achievable performance for the overlapping ACE techniques. The overlapping ACE techniques on the other hand can handle symbol by symbol processing. Furthermore, as a result of FBMC properties, the proposed techniques do not require side information transmission. The PAPR performance of the techniques is shown to match, or in some cases improve, on current PAPR techniques for FBMC. Initial analysis of the computational complexity of the SGP techniques indicates that the complexity issues with PAPR reduction in FBMC implementations can be addressed. The out-of-band interference introduced by the techniques is investigated. As a result, it is shown that the interference can be compensated for, whilst still maintaining decent PAPR performance. Additional results are also provided by means of a study of the PAPR reduction of the proposed techniques at a fixed clipping probability. The bit error rate (BER) degradation is investigated to ensure that the trade-off in terms of BER degradation is not too severe. As illustrated by exhaustive simulations, the SGP ACE-based technique proposed are ideal candidates for practical implementation in systems employing the low-complexity polyphase implementation of FBMC modulators. The methods are shown to offer significant PAPR reduction and increase the feasibility of FBMC as

  15. Review of physical and socio-economic characteristics and intervention approaches of informal settlements

    CSIR Research Space (South Africa)

    Wekesa, BW

    2011-04-01

    Full Text Available -1 Habitat International Volume 35, Issue 2, April 2011, Pages 238-245 A review of physical and socio-economic characteristics and intervention approaches of informal settlements B.W. Wekesaa, b, , , G.S. Steyna, 1, , F.A.O. (Fred) Otienoc, 2, , a... a literature survey, this paper reviews physical and socio-economic characteristics and the factors attributed to proliferation of the informal settlements and intervention approaches. The main objective was to establish how such settlements could...

  16. Economic evaluation of environmental impacts of open cast mining project - an approach

    International Nuclear Information System (INIS)

    Maiti, S.K.; Pathak, K.

    1998-01-01

    Economic valuation of environmental attributes are pragmatic approach to evaluating the impacts and it helps decision makers to arrive at objective decisions on the basis of cost benefit ratio. For determining the physical impact and its quantification, four evaluation methods, namely-market price method, surrogate market price, survey based and cost based approaches are generally used. The present paper reviews the importance of environmental evaluation of impacts of mining and also reviews a few suitable methodologies that could be effectively used for economic evaluation of environmental impacts in open cast mining projects. (author)

  17. Expression and evolutionary analyses of three acetylcholinesterase genes (Mi-ace-1, Mi-ace-2, Mi-ace-3) in the root-knot nematode Meloidogyne incognita.

    Science.gov (United States)

    Cui, Ruqiang; Zhang, Lei; Chen, Yuyan; Huang, Wenkun; Fan, Chengming; Wu, Qingsong; Peng, Deliang; da Silva, Washington; Sun, Xiaotang

    2017-05-01

    The full cDNA of Mi-ace-3 encoding an acetylcholinesterase (AChE) in Meloidogyne incognita was cloned and characterized. Mi-ace-3 had an open reading frame of 1875 bp encoding 624 amino acid residues. Key residues essential to AChE structure and function were conserved. The deduced Mi-ACE-3 protein sequence had 72% amino acid similarity with that of Ditylenchus destructor Dd-AChE-3. Phylogenetic analyses using 41 AChEs from 24 species showed that Mi-ACE-3 formed a cluster with 4 other nematode AChEs. Our results revealed that the Mi-ace-3 cloned in this study, which is orthologous to Caenorhabditis elegans AChE, belongs to the nematode ACE-3/4 subgroup. There was a significant reduction in the number of galls in transgenic tobacco roots when Mi-ace-1, Mi-ace-2, and Mi-ace-3 were knocked down simultaneously, whereas little or no effect were observed when only one or two of these genes were knocked down. This is an indication that the functions of these three genes are redundant. Copyright © 2017. Published by Elsevier Inc.

  18. Validation of ozone measurements from the Atmospheric Chemistry Experiment (ACE

    Directory of Open Access Journals (Sweden)

    E. Dupuy

    2009-01-01

    Full Text Available This paper presents extensive {bias determination} analyses of ozone observations from the Atmospheric Chemistry Experiment (ACE satellite instruments: the ACE Fourier Transform Spectrometer (ACE-FTS and the Measurement of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation (ACE-MAESTRO instrument. Here we compare the latest ozone data products from ACE-FTS and ACE-MAESTRO with coincident observations from nearly 20 satellite-borne, airborne, balloon-borne and ground-based instruments, by analysing volume mixing ratio profiles and partial column densities. The ACE-FTS version 2.2 Ozone Update product reports more ozone than most correlative measurements from the upper troposphere to the lower mesosphere. At altitude levels from 16 to 44 km, the average values of the mean relative differences are nearly all within +1 to +8%. At higher altitudes (45–60 km, the ACE-FTS ozone amounts are significantly larger than those of the comparison instruments, with mean relative differences of up to +40% (about +20% on average. For the ACE-MAESTRO version 1.2 ozone data product, mean relative differences are within ±10% (average values within ±6% between 18 and 40 km for both the sunrise and sunset measurements. At higher altitudes (~35–55 km, systematic biases of opposite sign are found between the ACE-MAESTRO sunrise and sunset observations. While ozone amounts derived from the ACE-MAESTRO sunrise occultation data are often smaller than the coincident observations (with mean relative differences down to −10%, the sunset occultation profiles for ACE-MAESTRO show results that are qualitatively similar to ACE-FTS, indicating a large positive bias (mean relative differences within +10 to +30% in the 45–55 km altitude range. In contrast, there is no significant systematic difference in bias found for the ACE-FTS sunrise and sunset measurements.

  19. Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE.

    Science.gov (United States)

    Sun, Xiaoou; Wiesner, Burkhard; Lorenz, Dorothea; Papsdorf, Gisela; Pankow, Kristin; Wang, Po; Dietrich, Nils; Siems, Wolf-Eberhard; Maul, Björn

    2008-12-01

    Angiotensin-converting enzyme (ACE) demonstrates, besides its typical dipeptidyl-carboxypeptidase activity, several unusual functions. Here, we demonstrate with molecular, biochemical, and cellular techniques that the somatic wild-type murine ACE (mACE), stably transfected in Chinese Hamster Ovary (CHO) or Madin-Darby Canine Kidney (MDCK) cells, interacts with endogenous membranal co-localized carboxypeptidase M (CPM). CPM belongs to the group of glycosylphosphatidylinositol (GPI)-anchored proteins. Here we report that ACE, completely independent of its known dipeptidase activities, has GPI-targeted properties. Our results indicate that the spatial proximity between mACE and the endogenous CPM enables an ACE-evoked release of CPM. These results are discussed with respect to the recently proposed GPI-ase activity and function of sperm-bound ACE.

  20. The Comprehensive Approach to Assessing the Economic Security of the Industry Sector in Conditions of Globalization

    Directory of Open Access Journals (Sweden)

    Denysov Oleg Ye.

    2018-01-01

    Full Text Available The author carries out an empirical study of the level of economic security of the chemical industry sector of Ukraine in the direction of «production of polyvinyl chlorides». For this purpose the integral index of economic security has been calculated according to the model of functional-component blocks of economic security of sector, developed by the author. Application of this model allowed to research the algorithm of action of the model on the factual basis and to analyze the obtained indicators. This, in turn, made possible to draw a conclusion about the constructiveness and expediency of application of the model of basic functional-component blocks for calculating the level of economic security of the industry sector. With the help of this approach, with application of the complex, system-structural, dynamic and functional approaches, the level of economic security has been defined and the process of monitoring the status and level of economic security of the industry sector has been ensured.

  1. Approach and development strategy for an agent-based model of economic confidence.

    Energy Technology Data Exchange (ETDEWEB)

    Sprigg, James A.; Pryor, Richard J.; Jorgensen, Craig Reed

    2004-08-01

    We are extending the existing features of Aspen, a powerful economic modeling tool, and introducing new features to simulate the role of confidence in economic activity. The new model is built from a collection of autonomous agents that represent households, firms, and other relevant entities like financial exchanges and governmental authorities. We simultaneously model several interrelated markets, including those for labor, products, stocks, and bonds. We also model economic tradeoffs, such as decisions of households and firms regarding spending, savings, and investment. In this paper, we review some of the basic principles and model components and describe our approach and development strategy for emulating consumer, investor, and business confidence. The model of confidence is explored within the context of economic disruptions, such as those resulting from disasters or terrorist events.

  2. The economic approach to the problem of tax evasion and recommendations for Serbia

    Directory of Open Access Journals (Sweden)

    Milosavljević Valentina

    2016-01-01

    Full Text Available Tax evasion is a global problem and it has severe consequences for every country, regardless of differences in socio-economic and political structure. The basis for tax criminal offenses is embodied in different manifestations of tax evasion, especially when taking into account that tax evasion is also the most important form of informal economy. Since the taxation achieves not only fiscal, but also objectives in the field of economic and social policy, tax evasion has consequences on the economic and socio-political level. After introductory considerations, the paper shows the topicality of this issue, then the analysis of theoretical and practical features of tax evasion, as the basic fiscal criminal offense in the new Criminal Law of the Republic of Serbia, while the economic approach to the problem of tax evasion is based on an analysis of individual behavior of taxpayers.

  3. The Effects of Unemployment on Economic Growth in Greece. An ARDL Bound Test Approach.

    Directory of Open Access Journals (Sweden)

    Nikolaos Dritsakis

    2016-12-01

    Full Text Available The aim of this paper is to investigate the relationship between unemployment rate, economic growth and inflation rate in Greece, using annual data covering the period 1995-2015. The unit root tests results indicated that the variables have different integration order. Subsequently, the bounds testing (ARDL approach and ECM-ARDL model are applied in order to examine the long-run and the causal relationship between the variables. The empirical results of the study revealed, both in the short and long-run, that there is a unidirectional causal relationship between unemployment and economic growth with direction from unemployment to economic growth, as well as a unidirectional causality running from inflation to economic growth.

  4. The Analysis of Theoretical Approaches to Identification of Factors of Regional Economic Growth

    Directory of Open Access Journals (Sweden)

    Kosyrieva Olena V.

    2016-05-01

    Full Text Available The article is devoted to the investigation of current approaches to identification of factors of economic growth in the regions. The theory of new economic geography based on works and studies of P. Krugman has been considered. There highlighted the key issues of regional economic growth requiring an in-depth studying and consideration in the elaboration of strategies for sustainable development of the regions. The views of leading domestic and foreign scholars as well as the OECD experts, the World Bank, the National Statistics Service of the United Kingdom and others on the main drivers of economic growth have been analyzed. On the basis of the study the factors of regional economic growth most commonly encountered in theory and practice have been generalized. It is proved that scientists and analysts most often classify as the factors of regional economic growth the following ones: those characterizing human potential, scientific-technical and innovative activity, management and institutional capacity. The factors less frequently correlated by specialists and scientists with the regional economic growth include: those characterizing the environment, business and sociopolitical factors, which is associated with difficulty of their quantification, but in any case does not diminish their importance.

  5. Global equity allocation with index of economic freedom—A Black-Litterman equilibrium approach

    OpenAIRE

    Mohanty, Subhransu Sekhar

    2006-01-01

    The purpose of the present study is to examine the impact of Index of Economic Freedom (IEF) in strategic equity allocation process, in ternis of riskreturn efficiency, across 49 countries using the Black-Litterman's Absolute View approach. We have attempted to carry an ex-post comparative risk-return performance analysis of traditional CAPM, the Black-Litterman Equilibrium model and our view based strategy based on Black-Litterman's Absolute View approach to analyse whether our view-based st...

  6. Comparing Conventional Bank Credit Vis A Vis Shariah Bank Musharakah: Experimental Economic Approach

    Directory of Open Access Journals (Sweden)

    Muhamad Abduh

    2008-01-01

    Full Text Available Central Bank of Indonesia with dual banking system – i.e Shariah and Conventional Bank – keep on developing system that considered as an answer to generate the national economic growth. One of the banking activities that emphasized by the Central Bank of Indonesia is fund distribution through either conventional bank credit or shariah bank fi nancing. Having the Experimental Economic Approach based on Induced Value Theory and employing ANOVA, this paper found that shariah bank musharakah fi nancing system would come up with higher profi t opportunity compare to conventional credit system. One main reason is that musharakah fi nancing in shariah bank applies profi t and lost sharing (PLS scheme so that will not be a burden to the customer when he fi nd low profi t.Keywords: Credit Loan, Musharakah Financing, Induced Value Theory, Experimental Economic Approach, Analysis of Variance (ANOVA.

  7. ACES MWL data analysis center at SYRTE

    Science.gov (United States)

    Meynadier, F.; Delva, P.; le Poncin-Lafitte, C.; Guerlin, C.; Laurent, P.; Wolf, P.

    2017-12-01

    The ACES-PHARAO mission aims at operating a cold-atom caesium clock on board the International Space Station, and performs two-way time transfer with ground terminals, in order to allow highly accurate and stable comparisons of its internal timescale with those found in various metrology institutes. Scientific goals in fundamental physics include tests of the gravitational redshift with unprecedented accuracy, and search for a violation of the Lorentz local invariance. As launch is coming closer we are getting ready to process the data expected to come from ACES Microwave Link (MWL) once on board the International Space Station. Several hurdles have been cleared in our software in the past months, as we managed to implement algorithms that reach target accuracy for ground/space desynchronisation measurement. I will present the current status of data analysis preparation, as well as the activities that will take place at SYRTE in order to set up its data processing center.

  8. Modelling efficient innovative work: integration of economic and social psychological approaches

    Directory of Open Access Journals (Sweden)

    Babanova Yulia

    2017-01-01

    Full Text Available The article deals with the relevance of integration of economic and social psychological approaches to the solution of enhancing the efficiency of innovation management. The content, features and specifics of the modelling methods within each of approaches are unfolded and options of integration are considered. The economic approach lies in the generation of the integrated matrix concept of management of innovative development of an enterprise in line with the stages of innovative work and the use of the integrated vector method for the evaluation of the innovative enterprise development level. The social psychological approach lies in the development of a system of psychodiagnostic indexes of activity resources within the scope of psychological innovative audit of enterprise management and development of modelling methods for the balance of activity trends. Modelling the activity resources is based on the system of equations accounting for the interaction type of psychodiagnostic indexes. Integration of two approaches includes a methodological level, a level of empirical studies and modelling methods. There are suggested options of integrating the economic and psychological approaches to analyze available material and non-material resources of the enterprises’ innovative work and to forecast an optimal option of development based on the implemented modelling methods.

  9. Beyond economic games: a mutualistic approach to the rest of moral life.

    Science.gov (United States)

    Graham, Jesse

    2013-02-01

    Mutualism provides a compelling account of the fairness intuitions on display in economic games. However, it is not yet clear how well the approach holds up as an explanation of all human morality. The theory needs to be tested outside the methodological neighborhood it was born in; such testing has the potential to greatly improve our understanding of morality in general.

  10. Modeling the economic impact of medication adherence in type 2 diabetes: a theoretical approach.

    Science.gov (United States)

    Cobden, David S; Niessen, Louis W; Rutten, Frans Fh; Redekop, W Ken

    2010-09-07

    While strong correlations exist between medication adherence and health economic outcomes in type 2 diabetes, current economic analyses do not adequately consider them. We propose a new approach to incorporate adherence in cost-effectiveness analysis. We describe a theoretical approach to incorporating the effect of adherence when estimating the long-term costs and effectiveness of an antidiabetic medication. This approach was applied in a Markov model which includes common diabetic health states. We compared two treatments using hypothetical patient cohorts: injectable insulin (IDM) and oral (OAD) medications. Two analyses were performed, one which ignored adherence (analysis 1) and one which incorporated it (analysis 2). Results from the two analyses were then compared to explore the extent to which adherence may impact incremental cost-effectiveness ratios. In both analyses, IDM was more costly and more effective than OAD. When adherence was ignored, IDM generated an incremental cost-effectiveness of $12,097 per quality-adjusted life-year (QALY) gained versus OAD. Incorporation of adherence resulted in a slightly higher ratio ($16,241/QALY). This increase was primarily due to better adherence with OAD than with IDM, and the higher direct medical costs for IDM. Incorporating medication adherence into economic analyses can meaningfully influence the estimated cost-effectiveness of type 2 diabetes treatments, and should therefore be considered in health care decision-making. Future work on the impact of adherence on health economic outcomes, and validation of different approaches to modeling adherence, is warranted.

  11. Adaptation, interaction and urgency : a complex evolutionary economic geography approach to leisure

    NARCIS (Netherlands)

    Meekes, Jasper F.; Buda, Dorina M.; de Roo, Gert

    2017-01-01

    Local and regional governments in western European peripheral areas aim to spur leisure-led regional development. We explore planning for leisure by applying an evolutionary economic geography (EEG) approach from a complexity perspective. We identify conditions which enable and constrain leisure

  12. TiO2 nanoparticles prepared without harmful organics: A biosafe and economical approach

    KAUST Repository

    Shah, M.A.; Al-Marzouki, F.M.

    2011-01-01

    Growth of titanium oxide (TiO2) nanoparticles of varying size, ranging from 20-60 nms through a versatile and an economic route, is being reported. The approach is based on a simple reaction of titanium powder and De-Ionized (DI) water at ∼180 °C

  13. A basic period approach to the economic lot scheduling problem with shelf life considerations

    NARCIS (Netherlands)

    Soman, C.A.; van Donk, D.P.; Gaalman, G.J.C.

    2004-01-01

    Almost all the research on the economic lot scheduling problem (ELSP) considering limited shelf life of products has assumed a common cycle approach and an unrealistic assumption of possibility of deliberately reducing the production rate. In many cases, like in food processing industry where

  14. Methodological approach to simulation and choice of ecologically efficient and energetically economic wind turbines (WT)

    Science.gov (United States)

    Bespalov, Vadim; Udina, Natalya; Samarskaya, Natalya

    2017-10-01

    Use of wind energy is related to one of the prospective directions among renewed energy sources. A methodological approach is reviewed in the article to simulation and choice of ecologically efficient and energetically economic wind turbines on the designing stage taking into account characteristics of natural-territorial complex and peculiarities of anthropogenic load in the territory of WT location.

  15. Modeling the economic impact of medication adherence in type 2 diabetes: a theoretical approach

    Directory of Open Access Journals (Sweden)

    David S Cobden

    2010-08-01

    Full Text Available David S Cobden1, Louis W Niessen2, Frans FH Rutten1, W Ken Redekop11Department of Health Policy and Management, Section of Health Economics – Medical Technology Assessment (HE-MTA, Erasmus MC, Erasmus University Rotterdam, The Netherlands; 2Department of International Health, Johns Hopkins University School of Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, USAAims: While strong correlations exist between medication adherence and health economic outcomes in type 2 diabetes, current economic analyses do not adequately consider them. We propose a new approach to incorporate adherence in cost-effectiveness analysis.Methods: We describe a theoretical approach to incorporating the effect of adherence when estimating the long-term costs and effectiveness of an antidiabetic medication. This approach was applied in a Markov model which includes common diabetic health states. We compared two treatments using hypothetical patient cohorts: injectable insulin (IDM and oral (OAD medications. Two analyses were performed, one which ignored adherence (analysis 1 and one which incorporated it (analysis 2. Results from the two analyses were then compared to explore the extent to which adherence may impact incremental cost-effectiveness ratios.Results: In both analyses, IDM was more costly and more effective than OAD. When adherence was ignored, IDM generated an incremental cost-effectiveness of $12,097 per quality-adjusted life-year (QALY gained versus OAD. Incorporation of adherence resulted in a slightly higher ratio ($16,241/QALY. This increase was primarily due to better adherence with OAD than with IDM, and the higher direct medical costs for IDM.Conclusions: Incorporating medication adherence into economic analyses can meaningfully influence the estimated cost-effectiveness of type 2 diabetes treatments, and should therefore be ­considered in health care decision-making. Future work on the impact of adherence on health ­economic

  16. The Contribution of the Neo-Schumpeterian Approach to the Development of the Economic Theory: Emphasis on the Meso-Economic Level

    Directory of Open Access Journals (Sweden)

    Radu HERMAN

    2011-07-01

    Full Text Available This article tries to show that there are alternative approaches to the economic theory, besides the well-known economic schools, Classicism, Neoclassicism and Keynesianism. The neoclassical principles allow a formalization – widely accepted by experts – that provide effective tools for measuring the effects of the economic activity. The economic science pays a special attention to the study of the economic agents’ behaviors, and to the economic results obtained by them through economic activity. Any human science uses principles and works with assumptions, and the neoclassical assumptions have generated efficient tools for quantifying the economic outcomes, and for accounting the economic growth. But these hypothesis, such as the assumption of economic agents’ rationality, allow a very limited understanding of the behaviors of economic agents within the markets. The recent invention of the Nuclear Magnetic Resonance device, allowed the emrgence of a new scientific paradigm, the development of neurosciences. Researchers can observe at a high level of graphic detail various types of activities that occur in the human brain, and some economists have introduced in the study of the economic theory, for example, the assumption that the consumer is driven by emotions when purchasing quantities of goods and services. So, economists may look for additional theories to explain the behavior of the economic agents. An increasingly importance is given to the theoretical contributions built on the work of the economist Joseph Alois Schumpeter, who has an original economic approach based on his own principles. It is proposed to focus the attention on a mesoeconomic vision about the industry, to understand how resources are being allocated and reallocated between companies, and to study the economic processes of evolution, which are influenced by the emergence and dissemination of the innovations. It is supposed that the price is allocating the

  17. Electricity consumption and economic growth nexus in Portugal using cointegration and causality approaches

    International Nuclear Information System (INIS)

    Shahbaz, Muhammad; Tang, Chor Foon; Shahbaz Shabbir, Muhammad

    2011-01-01

    The aim of this paper is to re-examine the relationship between electricity consumption, economic growth, and employment in Portugal using the cointegration and Granger causality frameworks. This study covers the sample period from 1971 to 2009. We examine the presence of a long-run equilibrium relationship using the bounds testing approach to cointegration within the Unrestricted Error-Correction Model (UECM). Moreover, we examine the direction of causality between electricity consumption, economic growth, and employment in Portugal using the Granger causality test within the Vector Error-Correction Model (VECM). As a summary of the empirical findings, we find that electricity consumption, economic growth, and employment in Portugal are cointegrated and there is bi-directional Granger causality between the three variables in the long-run. With the exception of the Granger causality between electricity consumption and economic growth, the rest of the variables are also bi-directional Granger causality in the short-run. Furthermore, we find that there is unidirectional Granger causality running from economic growth to electricity consumption, but no evidence of reversal causality. - Highlights: → We re-examine the relationship between electricity consumption, economic growth, and employment in Portugal. → The electricity consumption and economic growth is causing each other in the long-run. → In the short-run, economic growth Granger-cause electricity consumption, but no evidence of reversal causality. → Energy conservation policy will deteriorate the process of economic growth in the long-run. → Portugal should increase investment on R and D to design new energy savings technology.

  18. Energy consumption and economic growth nexus in Tanzania: An ARDL bounds testing approach

    International Nuclear Information System (INIS)

    Odhiambo, Nicholas M.

    2009-01-01

    In this paper, we examine the intertemporal causal relationship between energy consumption and economic growth in Tanzania during the period of 1971-2006. Unlike the majority of the previous studies, we employ the newly developed autoregressive distributed lag (ARDL)-bounds testing approach by Pesaran et al. [2001. Bounds testing approaches to the analysis of level relationships. Journal of Applied Econometrics 16, 289-326] to examine this linkage. We also use two proxies of energy consumption, namely total energy consumption per capita and electricity consumption per capita. The results of the bounds test show that there is a stable long-run relationship between each of the proxies of energy consumption and economic growth. The results of the causality test, on the other hand, show that there is a unidirectional causal flow from total energy consumption to economic growth and a prima-facie causal flow from electricity consumption to economic growth. Overall, the study finds that energy consumption spurs economic growth in Tanzania

  19. Energy consumption and economic growth nexus in Tanzania. An ARDL bounds testing approach

    Energy Technology Data Exchange (ETDEWEB)

    Odhiambo, Nicholas M. [Economics Department, University of South Africa (UNISA), P.O. Box 392, UNISA, 0003, Pretoria (South Africa)

    2009-02-15

    In this paper, we examine the intertemporal causal relationship between energy consumption and economic growth in Tanzania during the period of 1971-2006. Unlike the majority of the previous studies, we employ the newly developed autoregressive distributed lag (ARDL)-bounds testing approach by Pesaran et al. [2001. Bounds testing approaches to the analysis of level relationships. Journal of Applied Econometrics 16, 289-326] to examine this linkage. We also use two proxies of energy consumption, namely total energy consumption per capita and electricity consumption per capita. The results of the bounds test show that there is a stable long-run relationship between each of the proxies of energy consumption and economic growth. The results of the causality test, on the other hand, show that there is a unidirectional causal flow from total energy consumption to economic growth and a prima-facie causal flow from electricity consumption to economic growth. Overall, the study finds that energy consumption spurs economic growth in Tanzania. (author)

  20. Energy consumption and economic growth nexus in Tanzania: An ARDL bounds testing approach

    Energy Technology Data Exchange (ETDEWEB)

    Odhiambo, Nicholas M. [Economics Department, University of South Africa (UNISA), P.O. Box 392, UNISA, 0003, Pretoria (South Africa)], E-mail: nmbaya99@yahoo.com

    2009-02-15

    In this paper, we examine the intertemporal causal relationship between energy consumption and economic growth in Tanzania during the period of 1971-2006. Unlike the majority of the previous studies, we employ the newly developed autoregressive distributed lag (ARDL)-bounds testing approach by Pesaran et al. [2001. Bounds testing approaches to the analysis of level relationships. Journal of Applied Econometrics 16, 289-326] to examine this linkage. We also use two proxies of energy consumption, namely total energy consumption per capita and electricity consumption per capita. The results of the bounds test show that there is a stable long-run relationship between each of the proxies of energy consumption and economic growth. The results of the causality test, on the other hand, show that there is a unidirectional causal flow from total energy consumption to economic growth and a prima-facie causal flow from electricity consumption to economic growth. Overall, the study finds that energy consumption spurs economic growth in Tanzania.

  1. A participatory systems approach to modeling social, economic, and ecological components of bioenergy

    International Nuclear Information System (INIS)

    Buchholz, Thomas S.; Volk, Timothy A.; Luzadis, Valerie A.

    2007-01-01

    Availability of and access to useful energy is a crucial factor for maintaining and improving human well-being. Looming scarcities and increasing awareness of environmental, economic, and social impacts of conventional sources of non-renewable energy have focused attention on renewable energy sources, including biomass. The complex interactions of social, economic, and ecological factors among the bioenergy system components of feedstock supply, conversion technology, and energy allocation have been a major obstacle to the broader development of bioenergy systems. For widespread implementation of bioenergy to occur there is a need for an integrated approach to model the social, economic, and ecological interactions associated with bioenergy. Such models can serve as a planning and evaluation tool to help decide when, where, and how bioenergy systems can contribute to development. One approach to integrated modeling is by assessing the sustainability of a bioenergy system. The evolving nature of sustainability can be described by an adaptive systems approach using general systems principles. Discussing these principles reveals that participation of stakeholders in all components of a bioenergy system is a crucial factor for sustainability. Multi-criteria analysis (MCA) is an effective tool to implement this approach. This approach would enable decision-makers to evaluate bioenergy systems for sustainability in a participatory, transparent, timely, and informed manner

  2. Two approaches to meeting the economic challenge for advanced BWR designs

    International Nuclear Information System (INIS)

    Arnold, H.; Rao, A.S.; Sawyer, C.D.

    1996-01-01

    In developing next generation nuclear power plants many economic challenges must be addressed before they become economically attractive to utilities. The economic challenges vary from country to country but have several common characteristics. First and foremost, a plant has to have the lowest construction (costs) to even be considered for design and construction. Additionally, the plant design has to a have a reasonable chance of being licensed by the regulatory authorities in order to minimize the financial risk to the constructing utility. With the long lead times involved in the design and development of advanced plants nowadays, the overall development costs have also become a key factor in the evolution of advanced plants. This paper presents the design overview and approach to addressing the aforementioned economic challenges for two Advanced Boiling Water Reactor (ABWR) designs. The first plant is the ABWR and the second is the European Simplified Boiling Water. The ABWR relies on proven technology and components and an extensive infrastructure that has been built up over the last 20 year. Because it has proven and standard safety systems, which have been licensed in two countries, it has very limited uncertainly regarding licensing. Finally, it relies on the economies of scale and design flexibility to improve the overall economics of power generation. The ESBWR on the other hand has taken an innovative approach to reduce systems and components to simplify the overall plant to improve plant economics. The overall plant design is indeed simpler, but improved economics required reliance on some economies of scale also. This design embodied in the ESBWR, also has minimized the overall development cost by utilizing features and components from the ABWR and Simplified Boiling Water Reactor technology programs. (authors)

  3. A combined energetic and economic approach for the sustainable design of geothermal plants

    International Nuclear Information System (INIS)

    Franco, Alessandro; Vaccaro, Maurizio

    2014-01-01

    Highlights: • Exploitation of medium to low temperature geothermal sources: ORC power plants. • Integrated energetic and economic approach for the analysis of geothermal power plants. • A brief overview of the cost items of geothermal power plants. • Analysis of specific cost of geothermal power plants based on the method proposed. • Analysis of sustainability of geothermal energy systems based on resource durability. - Abstract: The perspectives of future development of geothermal power plants, mainly of small size for the exploitation of medium–low temperature reservoirs, are discussed and analyzed in the present paper. Even if there is a general interest in new power plants and investments in this sector are recognized, the new installations are reduced; the apparent advantage of null cost of the energy source is negatively balanced by the high drilling and installation costs. A key element for the design of a geothermal plant for medium temperature geothermal source is the definition of the power of the plant (size): this is important in order to define not only the economic plan but also the durability of the reservoir. Considering that it is not possible that the development of geothermal industry could be driven only by an economic perspective, the authors propose a method for joining energetic and economic approaches. The result of the combined energetic and economic analysis is interesting particularly in case of Organic Rankine Cycle (ORC) power plants in order to define a suitable and optimal size and to maximize the resource durability. The method is illustrated with reference to some particular case studies, showing that the sustainability of small size geothermal plants will be approached only if the research for more economic solutions will be combined with efforts in direction of efficiency increase

  4. Examining carbon emissions economic growth nexus for India: A multivariate cointegration approach

    International Nuclear Information System (INIS)

    Ghosh, Sajal

    2010-01-01

    The study probes cointegration and causality between carbon emissions and economic growth for India using ARDL bounds testing approach complemented by Johansen-Juselius maximum likelihood procedure in a multivariate framework by incorporating energy supply, investment and employment for time span 1971-2006. The study fails to establish long-run equilibrium relationship and long term causality between carbon emissions and economic growth; however, there exists a bi-directional short-run causality between the two. Hence, in the short-run, any effort to reduce carbon emissions could lead to a fall in the national income. This study also establishes unidirectional short-run causality running from economic growth to energy supply and energy supply to carbon emissions. The absence of causality running from energy supply to economic growth implies that in India, energy conservation and energy efficiency measures can be implemented to minimize the wastage of energy across value chain. Such measures would narrow energy demand-supply gap. Absence of long-run causality between carbon emissions and economic growth implies that in the long-run, focus should be given on harnessing energy from clean sources to curb carbon emissions, which would not affect the country's economic growth.

  5. TAX COMPOSITION AND ECONOMIC GROWTH. A PANEL-MODEL APPROACH FOR EASTERN EUROPE

    Directory of Open Access Journals (Sweden)

    MURA PETRU-OVIDIU

    2015-03-01

    Full Text Available In this paper, we investigate the impact of tax composition on economic growth, based on a panel-model approach. The dataset includes six East-European countries and covers the period 1995-2012. Specifically, the study explores the relative impact of different components of tax revenue (direct and indirect tax revenue, as percentage of total tax revenue on economic growth. The paper adds marginally to the empirical literature, showing how the two types of tax revenue influence economic growth in Eastern Europe, under an extended set of economic and sociopolitical control variables. The most important empirical output, for the 6 investigated East-European countries during 1995-2012, suggests that direct taxes are significant and negatively correlated with economic growth, while indirect taxes exert a positive influence on the dependent variable, though insignificant. As for the control variables, it seems that only freedom from corruption and political stability have a significant impact on economic growth. The study suggests that the design of tax systems in Eastern European countries is in accordance with the Commission’s priorities regarding its growth-friendliness. As for policy implications, governments should continue shifting the tax burden away from labour on to tax bases linked to consumption, property, and combating pollution, with potential positive effects both for growth and for fighting against tax evasion.

  6. Tourism and Economic Growth in Sri Lanka: An ARDL Bounds Testing Approach

    OpenAIRE

    P. Srinivasan; Santhosh Kumar P. K; L. Ganesh

    2012-01-01

    The purpose of the study is to examine the impact of tourism on economic growth in Sri Lanka through the Autoregressive Distributed Lag (ARDL) bounds testing approach. The analysis was carried out for the period from 1969 to 2009. By and large, our analysis reveals that the tourism has a positive impact on economic growth in Sri Lanka both in the short-run and long-run. Hence, it is crucial for the Sri Lankan government to achieve unification and stability by focusing on political solutions t...

  7. New approaches to the design and economics of EHV transmission plant

    CERN Document Server

    Jones, Brian

    1972-01-01

    New Approaches to the Design and Economics of EHV Transmission Plant examines the limitations of EHV transmission plant. Analysis is also covered in the book to correct these limitations. The concept behind EHV is that allowable transfer of electricity is related to the square of the voltage. Factors such as the expense of supplying a certain volume of electricity over a given distance and creations of power stations are examined. The book provides economic studies of alternative design policies based on estimation of costs and benefits of the design parameters. The text also focuses on the pr

  8. Neuro-genetic hybrid approach for the solution of non-convex economic dispatch problem

    International Nuclear Information System (INIS)

    Malik, T.N.; Asar, A.U.

    2009-01-01

    ED (Economic Dispatch) is non-convex constrained optimization problem, and is used for both on line and offline studies in power system operation. Conventionally, it is solved as convex problem using optimization techniques by approximating generator input/output characteristic. Curves of monotonically increasing nature thus resulting in an inaccurate dispatch. The GA (Genetic Algorithm) has been used for the solution of this problem owing to its inherent ability to address the convex and non-convex problems equally. This approach brings the solution to the global minimum region of search space in a short time and then takes longer time to converge to near optimal results. GA based hybrid approaches are used to fine tune the near optimal results produced by GA. This paper proposes NGH (Neuro Genetic Hybrid) approach to solve the economic dispatch with valve point effect. The proposed approach combines the GA with the ANN (Artificial Neural Network) using SI (Swarm Intelligence) learning rule. The GA acts as a global optimizer and the neural network fine tunes the GA results to the desired targets. Three machines standard test system has been tested for validation of the approach. Comparing the results with GA and NGH model based on back-propagation learning, the proposed approach gives contrast improvements showing the promise of the approach. (author)

  9. Techno-economic analysis for the evaluation of three UCG synthesis gas end use approaches

    Science.gov (United States)

    Nakaten, Natalie; Kempka, Thomas; Burchart-Korol, Dorota; Krawczyk, Piotr; Kapusta, Krzysztof; Stańczyk, Krzysztof

    2016-04-01

    Underground coal gasification (UCG) enables the utilization of coal reserves that are economically not exploitable because of complex geological boundary conditions. In the present study we investigate UCG as a potential economic approach for conversion of deep-seated coals into a synthesis gas and its application within three different utilization options. Related to geological boundary conditions and the chosen gasification agent, UCG synthesis gas composes of varying methane, hydrogen, nitrogen, carbon monoxide and carbon dioxide amounts. In accordance to its calorific value, the processed UCG synthesis gas can be utilized in different manners, as for electricity generation in a combined cycle power plant or for feedstock production making use of its various chemical components. In the present study we analyze UCG synthesis gas utilization economics in the context of clean electricity generation with an integrated carbon capture and storage process (CCS) as well as synthetic fuel and fertilizer production (Kempka et al., 2010) based on a gas composition achieved during an in situ UCG trial in the Wieczorek Mine. Hereby, we also consider chemical feedstock production in order to mitigate CO2 emissions. Within a sensitivity analysis of UCG synthesis gas calorific value variations, we produce a range of capital and operational expenditure bandwidths that allow for an economic assessment of different synthesis gas end use approaches. To carry out the integrated techno-economic assessment of the coupled systems and the sensitivity analysis, we adapted the techno-economic UCG-CCS model developed by Nakaten et al. (2014). Our techno-economic modeling results demonstrate that the calorific value has a high impact on the economics of UCG synthesis gas utilization. In the underlying study, the synthesis gas is not suitable for an economic competitive electricity generation, due to the relatively low calorific value of 4.5 MJ/Nm³. To be a profitable option for electricity

  10. A new economic feasibility approach for solar chimney power plant design

    International Nuclear Information System (INIS)

    Okoye, Chiemeka Onyeka; Solyalı, Oğuz; Taylan, Onur

    2016-01-01

    Highlights: • A two-stage economic feasibility approach is proposed for the SCPP design. • The optimal size of the SCPP is determined by solving a nonlinear optimization model. • Energy demand and stochasticity of solar radiation and temperature are considered. • The proposed approach is evaluated on locations in Nigeria. • The proposed approach is an effective decision-making tool for the SCPP design. - Abstract: Solar chimney power plants have been accepted as one of the promising technologies for solar energy utilization. The objective of this study is to propose an effective approach to simultaneously determine the optimal dimensions of the solar chimney power plant and the economic feasibility of the proposed plant. For this purpose, a two-stage economic feasibility approach is proposed based on a new nonlinear programming model. In the first stage, the proposed optimization model which determines the optimal plant dimensions that not only minimize the discounted total cost of the system, but also satisfy the energy demand within a specified reliability taking into account the stochasticity of solar radiation and ambient temperature is solved using a commercial optimization solver that guarantees finding the global optimum. In the second stage, the net present value of building the plant is computed by deducting the discounted total cost found in the first stage from the present value of revenues obtained due to selling the electricity generated by the plant. The proposed approach is novel because it determines the optimal dimensions of the plant together with its economic feasibility by taking into account the energy demand and uncertainty in solar radiation and ambient temperature. The proposed approach is applied on a study in Potiskum, Nigeria, which reveals that building a plant with a collector diameter of 1128 m and chimney height of 715 m to Potiskum would be profitable for investors at an annual rate of return of 3% and would provide

  11. Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice.

    Directory of Open Access Journals (Sweden)

    Saurabh Chattopadhyay

    Full Text Available Angiotensin-converting enzyme (ACE regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS. Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All of these defects are cured by transgenic expression of somatic ACE (sACE in vascular endothelial cells of Ace-/- mice. sACE is expressed on the surface of vascular endothelial cells and undergoes a natural cleavage secretion process to generate a soluble form in the body fluids. Both the tissue-bound and the soluble forms of ACE are enzymatically active, and generate the vasoactive octapeptide Angiotensin II (Ang II with equal efficiency. To assess the relative physiological roles of the secreted and the cell-bound forms of ACE, we expressed, in the vascular endothelial cells of Ace-/- mice, the ectodomain of sACE, which corresponded to only the secreted form of ACE. Our results demonstrated that the secreted form of ACE could normalize kidney functions and RAS integrity, growth and development of Ace-/- mice, but not their blood pressure. This study clearly demonstrates that the secreted form of ACE cannot replace the tissue-bound ACE for maintaining normal blood pressure; a suitable balance between the tissue-bound and the soluble forms of ACE is essential for maintaining all physiological functions of ACE.

  12. Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice.

    Science.gov (United States)

    Chattopadhyay, Saurabh; Kessler, Sean P; Colucci, Juliana Almada; Yamashita, Michifumi; Senanayake, Preenie deS; Sen, Ganes C

    2014-01-01

    Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All of these defects are cured by transgenic expression of somatic ACE (sACE) in vascular endothelial cells of Ace-/- mice. sACE is expressed on the surface of vascular endothelial cells and undergoes a natural cleavage secretion process to generate a soluble form in the body fluids. Both the tissue-bound and the soluble forms of ACE are enzymatically active, and generate the vasoactive octapeptide Angiotensin II (Ang II) with equal efficiency. To assess the relative physiological roles of the secreted and the cell-bound forms of ACE, we expressed, in the vascular endothelial cells of Ace-/- mice, the ectodomain of sACE, which corresponded to only the secreted form of ACE. Our results demonstrated that the secreted form of ACE could normalize kidney functions and RAS integrity, growth and development of Ace-/- mice, but not their blood pressure. This study clearly demonstrates that the secreted form of ACE cannot replace the tissue-bound ACE for maintaining normal blood pressure; a suitable balance between the tissue-bound and the soluble forms of ACE is essential for maintaining all physiological functions of ACE.

  13. Toward an integrated approach to nutritional quality, environmental sustainability, and economic viability: research and measurement gaps.

    Science.gov (United States)

    Herforth, Anna; Frongillo, Edward A; Sassi, Franco; Mclean, Mireille Seneclauze; Arabi, Mandana; Tirado, Cristina; Remans, Roseline; Mantilla, Gilma; Thomson, Madeleine; Pingali, Prabhu

    2014-12-01

    Nutrition is affected by numerous environmental and societal causes. This paper starts with a simple framework based on three domains: nutritional quality, economic viability, and environmental sustainability, and calls for an integrated approach in research to simultaneously account for all three. It highlights limitations in the current understanding of each domain, and how they influence one another. Five research topics are identified: measuring the three domains (nutritional quality, economic viability, environmental sustainability); modeling across disciplines; furthering the analysis of food systems in relation to the three domains; connecting climate change and variability to nutritional quality; and increasing attention to inequities among population groups in relation to the three domains. For an integrated approach to be developed, there is a need to identify and disseminate available metrics, modeling techniques, and tools to researchers, practitioners, and policy makers. This is a first step so that a systems approach that takes into account potential environmental and economic trade-offs becomes the norm in analyzing nutrition and food-security patterns. Such an approach will help fill critical knowledge gaps and will guide researchers seeking to define and address specific research questions in nutrition in their wider socioeconomic and environmental contexts. © 2014 New York Academy of Sciences.

  14. User's manual ACE/ONED (Version 1.0)

    International Nuclear Information System (INIS)

    Lee, Ki Bok; Lee, Jeong Chan; Song, Jae Seung; Lee, Chang Kyu; Ji, Sung Kyun; Song, Jae Woong; Kim, Yong Rae; Chang, Jong Hwa

    1996-03-01

    This report explains installation of ACE/ONED code, structure of input and output, how to prepare input and introduces some sample inputs. ACE/ONED developed by KAERI is a two-group one-dimensional diffusion theory code for nuclear design and reactor simulations. The usage of ACE/ONED encompasses core follow calculation, load-following calculation, plant power control simulation, xenon oscillation simulation, control rod maneuvering, and so on. ACE/ONED programmed of FORTRAN 77 in most part can be run on almost all kinds of computer including personal computer. 4 tabs., 4 figs., 8 refs. (Author) .new

  15. The coordination aspect of institutions in the context of an evolutionary approach to economic dynamics

    Directory of Open Access Journals (Sweden)

    Zoran Stefanovic

    2015-08-01

    Full Text Available The paper provides an insight into the dominant trends of contemporary evolutionary economics and outlines the important issues related to the articulation of this approach in thinking about the economy. The paper also affirms a proposition on institutions as carrier structures of socio-economic evolution, whose numerous effects at the societal level are decoded through the coordination function. In addition to the market, the process of coordination also employs other non-market institutional structures, whose profile and operational principles are the product of the trajectories of cultural and historical evolution, different among social orders. Projects aimed at the transformation of the economic system are to be sensitized to an objectively conditioned diversity of the institutional structures of the world economy, and in this sense, should be very careful in the installation of „universal” reform solutions.

  16. The political economics of the permanent war and the political economics of the nuclear war. Strategic approaches for Latin America

    International Nuclear Information System (INIS)

    Gomez L, I.I.

    2005-01-01

    This work treats on the hypothesis that the American imperialism uses its nuclear arsenal for reforming geographical spaces that allow him to impel its economic development in the context of the progressive exhaustion of the natural resources of the planet and of the ferocious dispute for market niches and investment destinations, and like the political and military decisions crawl to the different scenarios of economic competition. In the chapter 1 it is insinuated like has been reproduced the Warlike-industrial Complex (CBI) American from the second world postwar period until the present time in the idea of explaining like it is that it is valorized to the capital in scale enlarged starting from the denominated sector producing of destruction means and understanding that the system specifically capitalist is a system where continually the is destroyed previously taken place to manufacture a new merchandise in a luck of creative destruction. In the chapter 2, the topic of the specific contradictions of the CBI is approached that disable him to be the tip of lance of the world imperialism. The chapter 3 try on the productive linkages in the production of nuclear bombs, as well as in the production of the vectors of nuclear transportation and on the implications derived for the world security of the different industries associated to the nuclear energy (as the petroleum, the electricity, the natural gas) and to the transportation vectors of these locating which you/they are the different States where the world supremacy is disputed and that they have like one of its so many negotiation-confrontation letters its nuclear strategic arsenals. What is looked for in a thermonuclear war is the enemy's total elimination, from their offensive capacity, their defensive capacity, until their supplies, their reservations, etc., with the result that the chapters 4 and 5 of this thesis are presented to offer a better understanding that they mean the nuclear arsenals in the

  17. Economic culture of the Tuvans within the scope of the sociocultural approach

    Directory of Open Access Journals (Sweden)

    Yuri V. Popkov

    2018-06-01

    Full Text Available In this article, the authors argue that for the periods of social turmoil, understanding culture as a set of norms controlling social behavior is limited and insufficient. A more adequate approach would involve interpreting culture as a specific historical version of the society’s existence in its qualitative form. This hearkens back to the sociocultural approach which postulates the culture as an ensemble, and the sociocultural construed as the social in the cultural variety. In this context, economic culture might be seen as a set of qualitative features of a specific economic entity shaped by the local conditions of development. With all its peculiarities, an economic culture appears an element of this sociocultural diversity. Studying the economic culture of Tuvans through the lens of the sociocultural approach and the notion of this diversity allows us to outline several important aspects of this issue, rarely addressed by the existing academic discourse. A focus should be made, for instance, not only on the dominant nomadic culture, but also on subdominant economic cultures which helped shape a number of skills and techniques. While nomadism helped develop unhurried and contemplative attitude to life, hunting demanded dynamic change, and agriculture and crafts called for diligence and meticulousness. A brief glance at the economic history of Tuvans allowed the authors to conclude that economic diversity both provides stability to the economic culture of Tuvan society and expresses its variegation, its capacity to develop through numerous modifications. This polymorphism acts as an important resource which helps launch the alternate routes of ethnic development. These routes rarely appear self-evident under the dominant type of economic culture which had been shaping the traditional life of Tuvan society. Tapping into this alternative potential can prove an important reserve for future development. An overview of ethnographic data helps

  18. China's Political-Economic Approach toward FTAs with East Asian Nations and Its Implications for Korea

    Directory of Open Access Journals (Sweden)

    Hyun-jun Cho

    2004-06-01

    Full Text Available Focusing on a political-economic perspective, this article examines on the background and objectives of China's approach toward FTAs with East Asian nations. It appears that China's strategy to regional economic integration recently has transformed from a passive direction to active initiative, pushing forward its winning strategies - economic liberalization and its resolve to become a regional leader - while spearheading projects to create a regional free trade zone. China has a tendency to take a serious view on the significance of non-economic factors or international politics and security in regard to pursuing FTAs with neighboring countries. Behind China's ASEAN+1 plan, the implication of security is deeply rooted; and through its pursuit of economic integration within the region, China seems to be seeking change in the regional security order. China has also been bringing security discussions into the mechanism of regional economic cooperation among Korea, China and Japan. China also appears to have a few types of ideological mentality when pursuing FTAs. It seems that China's "great-power mentality"(daguo xintai is somewhat robust. This mentality is prone to be extended to hegemonic contention within the region. If China combines the "great-power mentality" with nationalism in the process of pursuing FTAs with neighboring countries, then this might entail exclusive regionalism. Both Japan and China are basically in rivalry over regional hegemony, and competing for leadership in intra-regional FTA initiatives. In pursuing FTAs with South Korea, China and Japan seem to have quite a contradictory approach. Japan, which wants to control the rise of China, seems to be ruling out the China-Japan-Korea FTA plan and actively pursuing a Japan-Korea FTA. On the contrary, Beijing is expected to actively propose to pursue China-Korea FTA in order to hold back rapid progress in Japan-Korea FTA negotiations, which have already commenced. On the

  19. Multiobjective scatter search approach with new combination scheme applied to solve environmental/economic dispatch problem

    International Nuclear Information System (INIS)

    Athayde Costa e Silva, Marsil de; Klein, Carlos Eduardo; Mariani, Viviana Cocco; Santos Coelho, Leandro dos

    2013-01-01

    The environmental/economic dispatch (EED) is an important daily optimization task in the operation of many power systems. It involves the simultaneous optimization of fuel cost and emission objectives which are conflicting ones. The EED problem can be formulated as a large-scale highly constrained nonlinear multiobjective optimization problem. In recent years, many metaheuristic optimization approaches have been reported in the literature to solve the multiobjective EED. In terms of metaheuristics, recently, scatter search approaches are receiving increasing attention, because of their potential to effectively explore a wide range of complex optimization problems. This paper proposes an improved scatter search (ISS) to deal with multiobjective EED problems based on concepts of Pareto dominance and crowding distance and a new scheme for the combination method. In this paper, we have considered the standard IEEE (Institute of Electrical and Electronics Engineers) 30-bus system with 6-generators and the results obtained by proposed ISS algorithm are compared with the other recently reported results in the literature. Simulation results demonstrate that the proposed ISS algorithm is a capable candidate in solving the multiobjective EED problems. - Highlights: ► Economic dispatch. ► We solve the environmental/economic economic power dispatch problem with scatter search. ► Multiobjective scatter search can effectively improve the global search ability

  20. The Monte Carlo approach to the economics of a DEMO-like power plant

    Energy Technology Data Exchange (ETDEWEB)

    Bustreo, Chiara, E-mail: chiara.bustreo@igi.cnr.it; Bolzonella, Tommaso; Zollino, Giuseppe

    2015-10-15

    Highlights: • A steady state DEMO-like power plant is modelled with the FRESCO code. • The Monte Carlo method is used to assess the probability distribution of the COE. • Uncertainties on technical and economical aspects make the COE vary in a large range. • The COE can be nearly 2/3 to nearly 4 times the cost derived deterministically. - Abstract: An early assessment of the economics of a fusion power plant is a key step to ensure the technology viability in a future global energy system. The FRESCO code is here used to generate the technical, physical and economic model of a steady state DEMO-like power plant whose features are taken from the current European research activities on the DEMO design definition. The Monte Carlo method is used to perform stochastic analyses in order to assess the weight on the cost of electricity of uncertainties on technical and economical aspects. This study demonstrates that a stochastic approach offers a much better perspective over the spectrum of values that could be expected for the cost of electricity from fusion. Specifically, this analysis proves that the cost of electricity of the DEMO-like power plant studied could vary in quite large range, from nearly 2/3 to nearly 4 times the cost derived through a deterministic approach, by choosing reference values for all the stochastic parameters, taken from the literature.

  1. Genetic variants of ACE (Insertion/Deletion) and AGT (M268T) genes in patients with diabetes and nephropathy.

    Science.gov (United States)

    Shaikh, Rozeena; Shahid, Syed M; Mansoor, Qaisar; Ismail, Muhammad; Azhar, Abid

    2014-06-01

    Diabetes mellitus (DM) has been a growing epidemic worldwide and poses a major socio-economic challenge. The leading cause of DM death is nephropathy due to end-stage renal disease (ESRD). This study aims to identify the possible association of I/D variants of the ACE gene and M268T (rs699) of the AGT gene of renin-angiotensin-aldosterone system (RAAS). Study subjects include 115 patients with DM, 110 with diabetic nephropathy (DN) and 110 controls. Fasting blood samples were collected for biochemical analyses and PCR amplification of specific regions of the ACE and AGT genes using primers. The distribution of ACE (I/D) II 28.8%, ID 35.6% and DD 35.6% while in DN II 24.5%, ID 41% and DD 34.5%. The AGT (M268T) genotypes were distributed in DM as TT 30.4%, MT 66.9% and MM 2.6% while in DN subjects TT 56.4%, MT 42.7% and MM 0.9%. Significant differences were observed in the DD genotype and D allele of the ACE gene and the TT genotype and T allele of AGT genes between diabetic patients with and without nephropathy. The study may conclude that the D allele polymorphism in the ACE gene and the T allele polymorphism in AGT gene may be considered as genetic risk factors for the development of nephropathy in diabetes. © The Author(s) 2014.

  2. Numerical analysis for simulation of condensing vapor bubble using CFD-ACE+

    International Nuclear Information System (INIS)

    Goyal, P.; Dutta, Anu; Singh, R.K.

    2014-01-01

    The motion of bubbles is very complex. They may be subject to break-up or coalescence and may appear to move with a spiraling, zigzagging or rocking behavior. Recently, many studies have been carried out to numerically simulate the rising bubble in various conditions by using VOF approach. However, all the above studies were limited to adiabatic bubble where heat and mass transfer between the phases were not considered. In the present work, an attempt was made to capture the behaviour of condensing bubble flowing in a channel, by using commercial CFD code CFD-ACE+ through VOF model. A User-Defined Function was developed to simulate interfacial heat and mass transfer during condensation. The effect of condensation on bubble behavior was analyzed by comparing the behavior of condensing bubble with that of adiabatic bubble. For validation of CFD-ACE UDF of bubble condensation, a comparison was made with the literature quoted experimental data and it agreed well. Through this work an emphasis was put on VOF module along with the development of an UDF for bubble condensation in CFD-ACE+ code. This theoretical study is motivated by the future CFD application and the intent to investigate the capabilities of the CFD-ACE+ package. (author)

  3. Computational investigation of fluid flow and heat transfer of an economizer by porous medium approach

    Science.gov (United States)

    Babu, C. Rajesh; Kumar, P.; Rajamohan, G.

    2017-07-01

    Computation of fluid flow and heat transfer in an economizer is simulated by a porous medium approach, with plain tubes having a horizontal in-line arrangement and cross flow arrangement in a coal-fired thermal power plant. The economizer is a thermal mechanical device that captures waste heat from the thermal exhaust flue gasses through heat transfer surfaces to preheat boiler feed water. In order to evaluate the fluid flow and heat transfer on tubes, a numerical analysis on heat transfer performance is carried out on an 110 t/h MCR (Maximum continuous rating) boiler unit. In this study, thermal performance is investigated using the computational fluid dynamics (CFD) simulation using ANSYS FLUENT. The fouling factor ε and the overall heat transfer coefficient ψ are employed to evaluate the fluid flow and heat transfer. The model demands significant computational details for geometric modeling, grid generation, and numerical calculations to evaluate the thermal performance of an economizer. The simulation results show that the overall heat transfer coefficient 37.76 W/(m2K) and economizer coil side pressure drop of 0.2 (kg/cm2) are found to be conformity within the tolerable limits when compared with existing industrial economizer data.

  4. Towards a New Approach of the Economic Intelligence Process: Basic Concepts, Analysis Methods and Informational Tools

    Directory of Open Access Journals (Sweden)

    Sorin Briciu

    2009-04-01

    Full Text Available One of the obvious trends in current business environment is the increased competition. In this context, organizations are becoming more and more aware of the importance of knowledge as a key factor in obtaining competitive advantage. A possible solution in knowledge management is Economic Intelligence (EI that involves the collection, evaluation, processing, analysis, and dissemination of economic data (about products, clients, competitors, etc. inside organizations. The availability of massive quantities of data correlated with advances in information and communication technology allowing for the filtering and processing of these data provide new tools for the production of economic intelligence.The research is focused on innovative aspects of economic intelligence process (models of analysis, activities, methods and informational tools and is providing practical guidelines for initiating this process. In this paper, we try: (a to contribute to a coherent view on economic intelligence process (approaches, stages, fields of application; b to describe the most important models of analysis related to this process; c to analyze the activities, methods and tools associated with each stage of an EI process.

  5. Multiple ace genes encoding acetylcholinesterases of Caenorhabditis elegans have distinct tissue expression.

    Science.gov (United States)

    Combes, Didier; Fedon, Yann; Toutant, Jean-Pierre; Arpagaus, Martine

    2003-08-01

    ace-1 and ace-2 genes encoding acetylcholinesterase in the nematode Caenorhabditis elegans present 35% identity in coding sequences but no homology in noncoding regions (introns, 5'- and 3'-untranslated regions). A 5'-region of ace-2 was defined by rescue of ace-1;ace-2 mutants. When green fluorescent protein (GFP) expression was driven by this regulatory region, the resulting pattern was distinct from that of ace-1. This latter gene is expressed in all body-wall and vulval muscle cells (Culetto et al., 1999), whereas ace-2 is expressed almost exclusively in neurons. ace-3 and ace-4 genes are located in close proximity on chromosome II (Combes et al., 2000). These two genes were first transcribed in vivo as a bicistronic messenger and thus constitute an ace-3;ace-4 operon. However, there was a very low level of monocistronic mRNA of ace-4 (the upstream gene) in vivo, and no ACE-4 enzymatic activity was ever detected. GFP expression driven by a 5' upstream region of the ace-3;ace-4 operon was detected in several muscle cells of the pharynx (pm3, pm4, pm5 and pm7) and in the two canal associated neurons (CAN cells). A dorsal row of body-wall muscle cells was intensively labelled in larval stages but no longer detected in adults. The distinct tissue-specific expression of ace-1, ace-2 and ace-3 (coexpressed only in pm5 cells) indicates that ace genes are not redundant.

  6. Betydningen af deletionspolymorfi i ACE-genet for progression af ACE-haemmerbehandlet diabetisk nyresygdom

    DEFF Research Database (Denmark)

    Tarnow, L; Parving, H H; Jacobsen, P

    1998-01-01

    The aim of the study was to evaluate the effect of an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene on progression of diabetic nephropathy. We performed an observational follow-up study of 35 patients with insulin-dependent diabetes and diabetic nephropathy. Pati...

  7. An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

    Science.gov (United States)

    Gordon, Kerry; Nesterovitch, Andrew B.; Lünsdorf, Heinrich; Chen, Zhenlong; Castellon, Maricela; Popova, Isolda A.; Kalinin, Sergey; Mendonca, Emma; Petukhov, Pavel A.; Schwartz, David E.

    2011-01-01

    Background Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously, a striking familial elevation in blood ACE was explained by mutations in the ACE juxtamembrane region that enhanced the cleavage-secretion process. Recently, we found a family whose affected members had a 6-fold increase in blood ACE and a Tyr465Asp (Y465D) substitution, distal to the stalk region, in the N domain of ACE. Methodology/Principal Findings HEK and CHO cells expressing mutant (Tyr465Asp) ACE demonstrate a 3- and 8-fold increase, respectively, in the rate of ACE shedding compared to wild-type ACE. Conformational fingerprinting of mutant ACE demonstrated dramatic changes in ACE conformation in several different epitopes of ACE. Cell ELISA carried out on CHO-ACE cells also demonstrated significant changes in local ACE conformation, particularly proximal to the stalk region. However, the cleavage site of the mutant ACE - between Arg1203 and Ser1204 - was the same as that of WT ACE. The Y465D substitution is localized in the interface of the N-domain dimer (from the crystal structure) and abolishes a hydrogen bond between Tyr465 in one monomer and Asp462 in another. Conclusions/Significance The Y465D substitution results in dramatic increase in the rate of ACE shedding and is associated with significant local conformational changes in ACE. These changes could result in increased ACE dimerization and accessibility of the stalk region or the entire sACE, thus increasing the rate of cleavage by the putative ACE secretase (sheddase). PMID:21998728

  8. An angiotensin I-converting enzyme mutation (Y465D causes a dramatic increase in blood ACE via accelerated ACE shedding.

    Directory of Open Access Journals (Sweden)

    Sergei M Danilov

    Full Text Available Angiotensin I-converting enzyme (ACE metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously, a striking familial elevation in blood ACE was explained by mutations in the ACE juxtamembrane region that enhanced the cleavage-secretion process. Recently, we found a family whose affected members had a 6-fold increase in blood ACE and a Tyr465Asp (Y465D substitution, distal to the stalk region, in the N domain of ACE.HEK and CHO cells expressing mutant (Tyr465Asp ACE demonstrate a 3- and 8-fold increase, respectively, in the rate of ACE shedding compared to wild-type ACE. Conformational fingerprinting of mutant ACE demonstrated dramatic changes in ACE conformation in several different epitopes of ACE. Cell ELISA carried out on CHO-ACE cells also demonstrated significant changes in local ACE conformation, particularly proximal to the stalk region. However, the cleavage site of the mutant ACE--between Arg1203 and Ser1204--was the same as that of WT ACE. The Y465D substitution is localized in the interface of the N-domain dimer (from the crystal structure and abolishes a hydrogen bond between Tyr465 in one monomer and Asp462 in another.The Y465D substitution results in dramatic increase in the rate of ACE shedding and is associated with significant local conformational changes in ACE. These changes could result in increased ACE dimerization and accessibility of the stalk region or the entire sACE, thus increasing the rate of cleavage by the putative ACE secretase (sheddase.

  9. From Physical Process to Economic Cost - Integrated Approaches of Landslide Risk Assessment

    Science.gov (United States)

    Klose, M.; Damm, B.

    2014-12-01

    The nature of landslides is complex in many respects, with landslide hazard and impact being dependent on a variety of factors. This obviously requires an integrated assessment for fundamental understanding of landslide risk. Integrated risk assessment, according to the approach presented in this contribution, implies combining prediction of future landslide occurrence with analysis of landslide impact in the past. A critical step for assessing landslide risk in integrated perspective is to analyze what types of landslide damage affected people and property in which way and how people contributed and responded to these damage types. In integrated risk assessment, the focus is on systematic identification and monetization of landslide damage, and analytical tools that allow deriving economic costs from physical landslide processes are at the heart of this approach. The broad spectrum of landslide types and process mechanisms as well as nonlinearity between landslide magnitude, damage intensity, and direct costs are some main factors explaining recent challenges in risk assessment. The two prevailing approaches for assessing the impact of landslides in economic terms are cost survey (ex-post) and risk analysis (ex-ante). Both approaches are able to complement each other, but yet a combination of them has not been realized so far. It is common practice today to derive landslide risk without considering landslide process-based cause-effect relationships, since integrated concepts or new modeling tools expanding conventional methods are still widely missing. The approach introduced in this contribution is based on a systematic framework that combines cost survey and GIS-based tools for hazard or cost modeling with methods to assess interactions between land use practices and landslides in historical perspective. Fundamental understanding of landslide risk also requires knowledge about the economic and fiscal relevance of landslide losses, wherefore analysis of their

  10. Education, Endogenous Human Capital, and Monetary Economic Growth with MIU Approach

    OpenAIRE

    Zhang, Wei-Bin

    2013-01-01

    This study builds a monetary growth model with inflation policy and education. The model is a synthesis of the Uzawa-Lucas two-sector growth model and traditional monetary model with the money-in-utility (MIU) approach. We show how money, physical capital and human capital interact over time under exogenous inflation policy in a free market economy. The dynamics of the economy is described by three differential equations. We show that the monetary economic system has a saddle equilibrium poin...

  11. The advanced containment experiments (ACE) Project

    International Nuclear Information System (INIS)

    Sehgal, B.R.; Ritzman, R.; Merilo, M.; Rahn, F.; Machiels, A.

    1992-01-01

    The overall structure and content of the ACE Project, which has been obtaining experimental data in four key areas of LWR severe accident technology are described. The key areas consist of filtration systems for vented containment concepts, radioiodine behavior in containment, the interaction of molten core material with structural concrete, and the use of water to terminate the core-concrete interaction process. Experiment procedures used in each phase of the work are summarized and the principal results and conclusions developed to date are discussed

  12. A machine learning approach for predicting the relationship between energy resources and economic development

    Science.gov (United States)

    Cogoljević, Dušan; Alizamir, Meysam; Piljan, Ivan; Piljan, Tatjana; Prljić, Katarina; Zimonjić, Stefan

    2018-04-01

    The linkage between energy resources and economic development is a topic of great interest. Research in this area is also motivated by contemporary concerns about global climate change, carbon emissions fluctuating crude oil prices, and the security of energy supply. The purpose of this research is to develop and apply the machine learning approach to predict gross domestic product (GDP) based on the mix of energy resources. Our results indicate that GDP predictive accuracy can be improved slightly by applying a machine learning approach.

  13. Designing medical technology for resilience: integrating health economics and human factors approaches.

    Science.gov (United States)

    Borsci, Simone; Uchegbu, Ijeoma; Buckle, Peter; Ni, Zhifang; Walne, Simon; Hanna, George B

    2018-01-01

    The slow adoption of innovation into healthcare calls into question the manner of evidence generation for medical technology. This paper identifies potential reasons for this including a lack of attention to human factors, poor evaluation of economic benefits, lack of understanding of the existing healthcare system and a failure to recognise the need to generate resilient products. Areas covered: Recognising a cross-disciplinary need to enhance evidence generation early in a technology's life cycle, the present paper proposes a new approach that integrates human factors and health economic evaluation as part of a wider systems approach to the design of technology. This approach (Human and Economic Resilience Design for Medical Technology or HERD MedTech) supports early stages of product development and is based on the recent experiences of the National Institute for Health Research London Diagnostic Evidence Co-operative in the UK. Expert commentary: HERD MedTech i) proposes a shift from design for usability to design for resilience, ii) aspires to reduce the need for service adaptation to technological constraints iii) ensures value of innovation at the time of product development, and iv) aims to stimulate discussion around the integration of pre- and post-market methods of assessment of medical technology.

  14. A Technical and Economic Optimization Approach to Exploring Offshore Renewable Energy Development in Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Larson, Kyle B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tagestad, Jerry D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Perkins, Casey J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Oster, Matthew R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Warwick, M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Geerlofs, Simon H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-09-01

    This study was conducted with the support of the U.S. Department of Energy’s (DOE’s) Wind and Water Power Technologies Office (WWPTO) as part of ongoing efforts to minimize key risks and reduce the cost and time associated with permitting and deploying ocean renewable energy. The focus of the study was to discuss a possible approach to exploring scenarios for ocean renewable energy development in Hawaii that attempts to optimize future development based on technical, economic, and policy criteria. The goal of the study was not to identify potentially suitable or feasible locations for development, but to discuss how such an approach may be developed for a given offshore area. Hawaii was selected for this case study due to the complex nature of the energy climate there and DOE’s ongoing involvement to support marine spatial planning for the West Coast. Primary objectives of the study included 1) discussing the political and economic context for ocean renewable energy development in Hawaii, especially with respect to how inter-island transmission may affect the future of renewable energy development in Hawaii; 2) applying a Geographic Information System (GIS) approach that has been used to assess the technical suitability of offshore renewable energy technologies in Washington, Oregon, and California, to Hawaii’s offshore environment; and 3) formulate a mathematical model for exploring scenarios for ocean renewable energy development in Hawaii that seeks to optimize technical and economic suitability within the context of Hawaii’s existing energy policy and planning.

  15. A predictive modeling approach to increasing the economic effectiveness of disease management programs.

    Science.gov (United States)

    Bayerstadler, Andreas; Benstetter, Franz; Heumann, Christian; Winter, Fabian

    2014-09-01

    Predictive Modeling (PM) techniques are gaining importance in the worldwide health insurance business. Modern PM methods are used for customer relationship management, risk evaluation or medical management. This article illustrates a PM approach that enables the economic potential of (cost-) effective disease management programs (DMPs) to be fully exploited by optimized candidate selection as an example of successful data-driven business management. The approach is based on a Generalized Linear Model (GLM) that is easy to apply for health insurance companies. By means of a small portfolio from an emerging country, we show that our GLM approach is stable compared to more sophisticated regression techniques in spite of the difficult data environment. Additionally, we demonstrate for this example of a setting that our model can compete with the expensive solutions offered by professional PM vendors and outperforms non-predictive standard approaches for DMP selection commonly used in the market.

  16. A Benders decomposition approach for a combined heat and power economic dispatch

    International Nuclear Information System (INIS)

    Abdolmohammadi, Hamid Reza; Kazemi, Ahad

    2013-01-01

    Highlights: • Benders decomposition algorithm to solve combined heat and power economic dispatch. • Decomposing the CHPED problem into master problem and subproblem. • Considering non-convex heat-power feasible region efficiently. • Solving 4 units and 5 units system with 2 and 3 co-generation units, respectively. • Obtaining better or as well results in terms of objective values. - Abstract: Recently, cogeneration units have played an increasingly important role in the utility industry. Therefore the optimal utilization of multiple combined heat and power (CHP) systems is an important optimization task in power system operation. Unlike power economic dispatch, which has a single equality constraint, two equality constraints must be met in combined heat and power economic dispatch (CHPED) problem. Moreover, in the cogeneration units, the power capacity limits are functions of the unit heat productions and the heat capacity limits are functions of the unit power generations. Thus, CHPED is a complicated optimization problem. In this paper, an algorithm based on Benders decomposition (BD) is proposed to solve the economic dispatch (ED) problem for cogeneration systems. In the proposed method, combined heat and power economic dispatch problem is decomposed into a master problem and subproblem. The subproblem generates the Benders cuts and master problem uses them as a new inequality constraint which is added to the previous constraints. The iterative process will continue until upper and lower bounds of the objective function optimal values are close enough and a converged optimal solution is found. Benders decomposition based approach is able to provide a good framework to consider the non-convex feasible operation regions of cogeneration units efficiently. In this paper, a four-unit system with two cogeneration units and a five-unit system with three cogeneration units are analyzed to exhibit the effectiveness of the proposed approach. In all cases, the

  17. A HUMANISING ECONOMIC APPROACH ON COMPETITION POLICY OR HOW THE BEHAVIORAL ECONOMICS BLENDS WITH “TRADITIONAL ECONOMICS”

    Directory of Open Access Journals (Sweden)

    Liviana Andreea Niminet

    2015-07-01

    Full Text Available Behavioral are crucial for understanding both the consumer’s attitude and firms’ attitude as well as for understanding the market outcomes. The past ten years brought a lot of attention from researchers and policy-makers on the behavioral economics issue. Classical, traditional economic models rely on the assumptions of rationality and ordered preferences. Behavioral economics explores interactions between demand and supply including information framing, the use of heuristics in decision-making and time-inconsistent preferences. The research on behavioral economics has led to an extensive debate about the relative merits of both traditional and behavioral economics. First of all we propose to highlight the advantages and disadvantages of behavioral economics versus traditional economics on a very sensitive issue: the competition policy. Then we address market issues that can be solved by means of behavioral economics afterwards turning out attention to the remedies of behavioral economics and ,last but not least, the United Kingdom successful model on the matter of competition policy.

  18. Angiotensin converting enzyme (ACE D/I) polymorphism and its ...

    African Journals Online (AJOL)

    Hepatitis C virus (HCV) infection is a global health problem in Egypt and causes different liver disease spectrum. Evidence indicates that angiotensin I converting enzyme (ACE) gene polymorphism may play a role in determining disease progression. We aimed to determine the association of ACE gene I/D polymorphism ...

  19. ACE: A Collaborative School Consultation Program for Secondary School Teachers

    Science.gov (United States)

    Couture, Caroline; Massé, Line

    2014-01-01

    This article presents a description of ACE (Accompagnement collaboratif des enseignants (Collaborative teacher accompaniment)), a new program designed to guide secondary school teachers in integrating students with behavioral problems in their classrooms. ACE proposes collaborative accompaniment inspired by behavioral and mental health…

  20. Comparison of the optimized conditions for genotyping of ACE ID ...

    African Journals Online (AJOL)

    ACE ID polymorphism is inevitable for genetic epidemiology of several cardiovascular and non cardiovascular diseases due to its direct influence on ACE activity level. In the present work, conditions were optimized for its analysis using conventional and direct blood PCR (DB PCR). Blood samples from nine normotensive ...

  1. Advances in Computer Entertainment. 10th International Conference, ACE 2013

    NARCIS (Netherlands)

    Reidsma, Dennis; Katayose, H.; Nijholt, Antinus; Unknown, [Unknown

    2013-01-01

    These are the proceedings of the 10th International Conference on Advances in Computer Entertainment (ACE 2013), hosted by the Human Media Interaction research group of the Centre for Telematics and Information Technology at the University of Twente, The Netherlands. The ACE series of conferences,

  2. ECONOMIC AND SOCIAL OPERATIONAL EFFICIENCY OF MARKET DISTRIBUTION OF INCOME: APPROACHES TO EVALUATION

    Directory of Open Access Journals (Sweden)

    Z. Halushka

    2015-03-01

    Full Text Available This article provides a comparison between scientific approaches to understanding the economic and social efficiency of market income distribution. Based on multidisciplinary approaches the essence of the concepts of fairness and efficiency in the distribution; explored approaches to combining efficiency and equity used in policy income distribution at different levels of management; the possible social and economic consequences of ineffective regulation of income in today’s economy. The analysis is based on comparing the four concepts of justice that are considered socially efficient. Considered: utilitarian, formulated by J. Bentham; egalitarian, which provides for equal distribution; market (liberal approach – to polar egalitarian and roulzianskyy that treats justice as fairness, approaches. Based on the generalization of existing approaches analyzed method of estimating social justice in the distribution and the possibility of its application. The structure of the article includes the following sections: 1.Views on terms of efficiency and equity in the distribution of resources and income; 2. Classical and modern approaches to combining efficiency and equity in the distribution; 3. Conflicts combination of the principles of fairness and efficiency in the distribution of incomes policy. The authors also noted that the uneven distribution of income acts as an objective reality, and the question is to prevent dangerous indicators of this unevenness. Market income distribution does not guarantee every person an acceptable level of income. The causes of irregularity are: differences in abilities, mental as well as physical; differences in possession of the property, in the educational level and group reasons associated with luck, chance, surprise win more. This is a definite social injustice market. State, taking a significant share of responsibility for maintaining a basic human right to a dignified life, organizes redistribution.

  3. Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding

    Science.gov (United States)

    Danilov, Sergei M.; Lünsdorf, Heinrich; Akinbi, Henry T.; Nesterovitch, Andrew B.; Epshtein, Yuliya; Letsiou, Eleftheria; Kryukova, Olga V.; Piegeler, Tobias; Golukhova, Elena Z.; Schwartz, David E.; Dull, Randal O.; Minshall, Richard D.; Kost, Olga A.; Garcia, Joe G. N.

    2016-01-01

    Angiotensin I-converting enzyme (ACE) hydrolyzes numerous peptides and is a critical participant in blood pressure regulation and vascular remodeling. Elevated tissue ACE levels are associated with increased risk for cardiovascular and respiratory disorders. Blood ACE concentrations are determined by proteolytic cleavage of ACE from the endothelial cell surface, a process that remains incompletely understood. In this study, we identified a novel ACE gene mutation (Arg532Trp substitution in the N domain of somatic ACE) that increases blood ACE activity 7-fold and interrogated the mechanism by which this mutation significantly increases blood ACE levels. We hypothesized that this ACE mutation disrupts the binding site for blood components which may stabilize ACE conformation and diminish ACE shedding. We identified the ACE-binding protein in the blood as lysozyme and also a Low Molecular Weight (LMW) ACE effector, bilirubin, which act in concert to regulate ACE conformation and thereby influence ACE shedding. These results provide mechanistic insight into the elevated blood level of ACE observed in patients on ACE inhibitor therapy and elevated blood lysozyme and ACE levels in sarcoidosis patients. PMID:27734897

  4. Economic valuation of environmental benefits from wastewater treatment processes: an empirical approach for Spain.

    Science.gov (United States)

    Hernández-Sancho, Francesc; Molinos-Senante, María; Sala-Garrido, Ramón

    2010-01-15

    Economic research into the design and implementation of policies for the efficient management of water resources has been emphasized by the European Water Framework Directive (Directive 2000/60/EC). The efficient implementation of policies to prevent the degradation and depletion of water resources requires determining their value in social and economic terms and incorporating this information into the decision-making process. A process of wastewater treatment has many associated environmental benefits. However, these benefits are often not calculated because they are not set by the market, due to inadequate property rights, the presence of externalities, and the lack of perfect information. Nevertheless, the valuation of these benefits is necessary to justify a suitable investment policy and a limited number of studies exist on the subject of the economic valuation of environmental benefits. In this paper, we propose a methodology based on the estimation of shadow prices for the pollutants removed in a treatment process. This value represents the environmental benefit (avoided cost) associated with undischarged pollution. This is a pioneering approach to the economic valuation of wastewater treatment. The comparison of these benefits with the internal costs of the treatment process will provide a useful indicator for the feasibility of wastewater treatment projects. Copyright 2009 Elsevier B.V. All rights reserved.

  5. Modelling the impact of mining on socio-economic infrastructure development: a system dynamics approach

    Directory of Open Access Journals (Sweden)

    Maluleke, George

    2016-12-01

    Full Text Available The contribution of mining activities to social infrastructure and human development is a complex socio-economic development issue in South Africa. Complexity theory has introduced a new approach to solving problems in social systems, recognising them as complex systems. The socio-economic development system in South Africa falls into this category of complex systems. Analysing such a system requires that a number of feedback loops and details about the issues be analysed simultaneously. This level of complexity is above a human’s ability to comprehend without the aid of tools such as systems thinking and system dynamics. The causality between investment in infrastructure capacity and socio-economic development is dynamic. The relationship is influenced by exogenous feedback that, if not managed, is likely to reverse itself. This paper presents the results of a system dynamics modelling of the relationship, based on the principle of relative attractiveness developed in previous system dynamics research. A Monte Carlo analysis is used to determine the sensitivity of the system to changes in feedback. The paper concludes that the limits to growth in a socio-economic environment are determined by more factors than the availability of capital, and also include land capacity constraints and skills shortage.

  6. A pedagogical approach to socially just relations in a Grade 11 Economics class

    Directory of Open Access Journals (Sweden)

    Zayd Waghid

    2016-05-01

    Full Text Available Post-apartheid schooling in South Africa is challenged with the task of contributing towards social justice, as has been evident from the emergence of a plethora of education policies following the promulgation of the South African Schools Act in 1996. One of the most significant ways in which social justice can be cultivated in schools, especially where exclusion and marginalisation have been in ascendancy for decades, is through improved pedagogical activities, which receive focus in this article. The article focuses on investigating how the learning goals for Grade 11 Economics with the aid of an educational technology, in particular Facebook, engender opportunities for socially just relations in the classroom. The researcher is concerned with how these learning goals are related to three underlying aspects of Economics education, namely sustainable development, equity (including equality and economic development, and how they may or may not engender opportunities for social justice. Critical discourse analysis is the research approach used to analyse learners' comments on Facebook in relation to their understandings of three films. It was found that it is possible to teach and learn education for social justice in the classroom. Learners treated one another equally; enacted their pedagogical relations equitably; and learnt to become economically aware of their society's developmental needs. Thus, it is recommended that education for social justice be cultivated in school classrooms through the use of Facebook.

  7. The angiotensin-converting enzyme (ACE) gene insertion/ deletion dimorphism tracks with higher serum ace activities in both younger and older subjects

    International Nuclear Information System (INIS)

    Frossard, Philippe M.; Hill, Susan H.; Obineche, Enyioma N.; Lestringant, Gilles G.

    1998-01-01

    The absence of a 287 base pair alu sequence in the ACE gene (D allele) is associated with higher ACE levels than its presence (I allele) in adults. We carried out a case control study of thr ACE*I/D dimorphism in relation to circulating ACE activities to evaluate associations between the two variables in adults, compared to younger (18 years or less) individuals. Genotypes of the ACE*I/D dimorphism were determined on DNA samples from a population of 164 random (unrelated) Emirtaes nationals, composed of groups: 112 subjects above 18 years of age (range=20-77), and 52 subjects of 18 years or less (range=1-18) and analyzed for putative associations with serum ACE activities. ACE*I/D genotypes of the 164 individualds were determined by assays based on polymerase chain reaction. ACE activities were determined on serum samples of these subjects bu colorimetric assays. The D allele was associared with increasd ACE values in both adult and younger individuals. Mean ACE activity levels associated with II, ID and DD genotypes, however, were 42%-61% higher in the 18 years and under group of subjects. The ACE*I/D marker accounted for 28% of the variance of the phenomenon determining ACE levels in adults, and for 30% among youngsters. The ACE*I/D dimorphism is correlated strongly with circulating ACE activities in both and young Emirati, subjects and the corresponding mean ACE activities were significantly higher among the youngsters. (author)

  8. Gender difference of serum angiotensin-converting enzyme (ACE) activity in DD genotype of ACE insertion/deletion polymorphism in elderly Chinese.

    Science.gov (United States)

    Zhang, Ya-Feng; Cheng, Qiong; Tang, Nelson L S; Chu, Tanya T W; Tomlinson, Brian; Liu, Fan; Kwok, Timothy C Y

    2014-12-01

    In this study we investigated the gender difference of serum angiotensin-converting enzyme (ACE) activity in a population of Hong Kong-dwelling elderly Chinese. A total of 1767 (843 male, 924 female) Hong Kong-dwelling elderly Chinese were recruited. ACE I/D genotypes were identified by polymerase chain reaction amplification and serum ACE activity was determined using a commercially available kinetic kit. ACE I/D genotype distribution was compared by chi-square test, the correlation between ACE I/D polymorphism and serum ACE activity was analysed by ANOVA test and gender difference of serum ACE activity of different genotypes was compared by independent sample t-test. No statistically significant difference of genotype distribution between male and female subjects was found. Serum ACE activity was significantly correlated with ACE genotype. Overall, there was no gender difference of serum ACE activity; however, when sub-grouping the subjects by ACE I/D genotype, male subjects with DD genotype had higher serum ACE activity than female subjects with DD genotype. No significant gender difference of genotype distribution was found in elderly Chinese. Serum ACE activity was significantly correlated with ACE I/D polymorphism in elderly Chinese. Male subjects with DD genotype had higher serum ACE activity than female subjects with DD genotype. © The Author(s) 2013.

  9. A Fuzzy MCDM Approach for Green Supplier Selection from the Economic and Environmental Aspects

    Directory of Open Access Journals (Sweden)

    Hsiu Mei Wang Chen

    2016-01-01

    Full Text Available Due to the challenge of rising public awareness of environmental issues and governmental regulations, green supply chain management (SCM has become an important issue for companies to gain environmental sustainability. Supplier selection is one of the key operational tasks necessary to construct a green SCM. To select the most suitable suppliers, many economic and environmental criteria must be considered in the decision process. Although numerous studies have used economic criteria such as cost, quality, and lead time in the supplier selection process, only some studies have taken into account the environmental issues. This study proposes a comprehensive fuzzy multicriteria decision making (MCDM approach for green supplier selection and evaluation, using both economic and environmental criteria. In the proposed approach, a fuzzy analytic hierarchy process (AHP is employed to determine the important weights of criteria under vague environment. In addition, a fuzzy technique for order performance by similarity to ideal solution (TOPSIS is used to evaluate and rank the potential suppliers. Finally, a case study in Luminance Enhancement Film (LEF industry is presented to illustrate the applicability and efficiency of the proposed method.

  10. Fuzzy logic approach to SWOT analysis for economics tasks and example of its computer realization

    Directory of Open Access Journals (Sweden)

    Vladimir CHERNOV

    2016-07-01

    Full Text Available The article discusses the widely used classic method of analysis, forecasting and decision-making in the various economic problems, called SWOT analysis. As known, it is a qualitative comparison of multicriteria degree of Strength, Weakness, Opportunity, Threat for different kinds of risks, forecasting the development in the markets, status and prospects of development of enterprises, regions and economic sectors, territorials etc. It can also be successfully applied to the evaluation and analysis of different project management tasks - investment, innovation, marketing, development, design and bring products to market and so on. However, in practical competitive market and economic conditions, there are various uncertainties, ambiguities, vagueness. Its making usage of SWOT analysis in the classical sense not enough reasonable and ineffective. In this case, the authors propose to use fuzzy logic approach and the theory of fuzzy sets for a more adequate representation and posttreatment assessments in the SWOT analysis. In particular, has been short showed the mathematical formulation of respective task and the main approaches to its solution. Also are given examples of suitable computer calculations in specialized software Fuzicalc for processing and operations with fuzzy input data. Finally, are presented considerations for interpretation of the results.

  11. Improving economics and safety of water cooled reactors. Proven means and new approaches

    International Nuclear Information System (INIS)

    2002-05-01

    Nuclear power plants (NPPs) with water cooled reactors [either light water reactors (LWRs) or heavy water reactors (HWRs)] constitute the large majority of the currently operating plants. Water cooled reactors can make a significant contribution to meeting future energy needs, to reducing greenhouse gas emissions, and to energy security if they can compete economically with fossil alternatives, while continuing to achieve a very high level of safety. It is generally agreed that the largest commercial barrier to the addition of new nuclear power capacity is the high capital cost of nuclear plants relative to other electricity generating alternatives. If nuclear plants are to form part of the future generating mix in competitive electricity markets, capital cost reduction through simplified designs must be an important focus. Reductions in operating, maintenance and fuel costs should also be pursued. The Department of Nuclear Energy of the IAEA is examining the competitiveness of nuclear power and the means for improving its economics. The objective of this TECDOC is to emphasize the need, and to identify approaches, for new nuclear plants with water cooled reactors to achieve competitiveness while maintaining high levels of safety. The cost reduction methods discussed herein can be implemented into plant designs that are currently under development as well as into designs that may be developed in the longer term. Many of the approaches discussed also generally apply to other reactor types (e.g. gas cooled and liquid metal cooled reactors). To achieve the largest possible cost reductions, proven means for reducing costs must be fully implemented, and new approaches described in this document should be developed and implemented. These new approaches include development of advanced technologies, increased use of risk-informed methods for evaluating the safety benefit of design features, and international consensus regarding commonly acceptable safety requirements that

  12. Improving economics and safety of water cooled reactors. Proven means and new approaches

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-05-01

    Nuclear power plants (NPPs) with water cooled reactors [either light water reactors (LWRs) or heavy water reactors (HWRs)] constitute the large majority of the currently operating plants. Water cooled reactors can make a significant contribution to meeting future energy needs, to reducing greenhouse gas emissions, and to energy security if they can compete economically with fossil alternatives, while continuing to achieve a very high level of safety. It is generally agreed that the largest commercial barrier to the addition of new nuclear power capacity is the high capital cost of nuclear plants relative to other electricity generating alternatives. If nuclear plants are to form part of the future generating mix in competitive electricity markets, capital cost reduction through simplified designs must be an important focus. Reductions in operating, maintenance and fuel costs should also be pursued. The Department of Nuclear Energy of the IAEA is examining the competitiveness of nuclear power and the means for improving its economics. The objective of this TECDOC is to emphasize the need, and to identify approaches, for new nuclear plants with water cooled reactors to achieve competitiveness while maintaining high levels of safety. The cost reduction methods discussed herein can be implemented into plant designs that are currently under development as well as into designs that may be developed in the longer term. Many of the approaches discussed also generally apply to other reactor types (e.g. gas cooled and liquid metal cooled reactors). To achieve the largest possible cost reductions, proven means for reducing costs must be fully implemented, and new approaches described in this document should be developed and implemented. These new approaches include development of advanced technologies, increased use of risk-informed methods for evaluating the safety benefit of design features, and international consensus regarding commonly acceptable safety requirements that

  13. Economic Analysis: An Approach to Provide Basic Guidance for Conducting and Reviewing Economic Analysis within the Venezuelan Navy.

    Science.gov (United States)

    1986-06-01

    la Armada (EMGAR)-- Staff of the Navy ------------------------- 18 b. Direction de Presupuesto Programac ion Ecomica (DIPPE)-Direction of Budget and...Economic Programming -------------------- 18 c. Cornite De Programacion y Presupuesto (CPP)-- Programming and Budget Committee-----------18 3. Major...development. This analysis is included in the annual budget. b. Direction de Presupuesto Programaclon Ecomica (DIPPE)- Direction of Budget and Economic

  14. Circulating ACE2 activity correlates with cardiovascular disease development

    Directory of Open Access Journals (Sweden)

    Katalin Úri

    2016-12-01

    Full Text Available It was shown recently that angiotensin-converting enzyme activity is limited by endogenous inhibition in vivo, highlighting the importance of angiotensin II (ACE2 elimination. The potential contribution of the ACE2 to cardiovascular disease progression was addressed. Serum ACE2 activities were measured in different clinical states (healthy, n=45; hypertensive, n=239; heart failure (HF with reduced ejection fraction (HFrEF n=141 and HF with preserved ejection fraction (HFpEF n=47. ACE2 activity was significantly higher in hypertensive patients (24.8±0.8 U/ml than that in healthy volunteers (16.2±0.8 U/ml, p=0.01. ACE2 activity further increased in HFrEF patients (43.9±2.1 U/ml, p=0.001 but not in HFpEF patients (24.6±1.9 U/ml when compared with hypertensive patients. Serum ACE2 activity negatively correlated with left ventricular systolic function in HFrEF, but not in hypertensive, HFpEF or healthy populations. Serum ACE2 activity had a fair diagnostic value to differentiate HFpEF from HFrEF patients in this study. Serum ACE2 activity correlates with cardiovascular disease development: it increases when hypertension develops and further increases when the cardiovascular disease further progresses to systolic dysfunction, suggesting that ACE2 metabolism plays a role in these processes. In contrast, serum ACE2 activity does not change when hypertension progresses to HFpEF, suggesting a different pathomechanism for HFpEF, and proposing a biomarker-based identification of these HF forms.

  15. Association of Angiotensin-Converting Enzyme ACE Gene Polymorphism with ACE Activity and Susceptibility to Vitiligo in Egyptian Population.

    Science.gov (United States)

    Badran, Dahlia I; Nada, Hesham; Hassan, Ranya

    2015-05-01

    The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene is associated with vitiligo in the Indians and Koreans, but not in those of English or Turkish background. We investigated the ACE (I/D) polymorphism in vitiligo patients for the first time in Egypt and compared serum ACE levels between vitiligo patients and controls. The present study was carried out in 100 vitiligo patients (40 males and 60 females) and in 100 healthy controls of an Egyptian population using the polymerase chain reaction genotyping method. The ACE genotype and allele frequency was significantly different between vitiligo patients and controls. Our results revealed a significant increase in the frequency of the ACE I allele (p=0.002; odds ratio: 1.99; 95% confidence intervals: 1.207-3.284) with an overrepresentation of I/D genotype in the vitiligo patient group. Furthermore, there was a significant difference between the segmental, nonsegmental, and focal vitiligo in ACE gene genotype distribution. Serum ACE levels were significantly increased in vitiligo patients compared to controls (p=0.034). This study suggests that, for the first time, ACE gene polymorphism confers susceptibility to vitiligo in the Egyptian population.

  16. Hurricane Sandy Economic Impacts Assessment: A Computable General Equilibrium Approach and Validation

    Energy Technology Data Exchange (ETDEWEB)

    Boero, Riccardo [Los Alamos National Laboratory; Edwards, Brian Keith [Los Alamos National Laboratory

    2017-08-07

    Economists use computable general equilibrium (CGE) models to assess how economies react and self-organize after changes in policies, technology, and other exogenous shocks. CGE models are equation-based, empirically calibrated, and inspired by Neoclassical economic theory. The focus of this work was to validate the National Infrastructure Simulation and Analysis Center (NISAC) CGE model and apply it to the problem of assessing the economic impacts of severe events. We used the 2012 Hurricane Sandy event as our validation case. In particular, this work first introduces the model and then describes the validation approach and the empirical data available for studying the event of focus. Shocks to the model are then formalized and applied. Finally, model results and limitations are presented and discussed, pointing out both the model degree of accuracy and the assessed total damage caused by Hurricane Sandy.

  17. Economic approaches to measuring the significance of food safety in international trade.

    Science.gov (United States)

    Caswell, J A

    2000-12-20

    International trade in food products has expanded rapidly in recent years. This paper presents economic approaches for analyzing the effects on trade in food products of the food safety requirements of governments and private buyers. Important economic incentives for companies to provide improved food safety arise from (1) public incentives such as ex ante requirements for sale of a product with sufficient quality and ex post penalties (liability) for sale of products with deficient quality, and (2) private incentives for producing quality such as internal performance goals (self-regulation) and the external (certification) requirements of buyers. The World Trade Organization's Sanitary Phytosanitary Agreement facilitates scrutiny of the benefits and costs of country-level regulatory programs and encourages regulatory rapprochement on food safety issues. Economists can help guide risk management decisions by providing estimates of the benefits and costs of programs to improve food safety and by analyzing their effect on trade in food products.

  18. Sviluppo e implementazione di un modello farmacoeconomico per valutare la costo efficacia di un ACE-inibitore nella prevenzione del rischio cardiovascolare

    Directory of Open Access Journals (Sweden)

    Sergio Iannazzo

    2003-09-01

    Full Text Available Cardiovascular disease (CVD remains one of the leading causes of mortality and morbidity worldwide. Since several pharmacological approaches are available for the reduction of incidence and severity of cardiovascular events and health resources in modern managed care systems are limited, the evaluation of the clinical and economical consequences of any treatment is very valuable for decison-makers and physicians. In this article we present a flexible pharmacoeconomic model that permits the calculation of the marginal costeffectiveness of cardiovascular prevention with ramipril, a drug of the class of ACE-inhibitors. The clinical data used for the modelization are derived from the HOPE (Heart Outcomes Prevention Evaluation study, a landmark cardiovascular prevention study that showed how the benefits of ACE-inhibition with ramipril go beyond the effects on blood pressure, while Italian epidemiological, demographic and economical data make the results appliable to the Italian population. The model, structured as a decision tree comparing the alternatives “to treat” or “not to treat” with Markow chains at the terminal nodes, calculates the marginal cost-effectiveness of the preventive treatment in terms of cost/year of live saved. The model is characterized by high flexibility, as it allows health decision-makers to set epidemiological and economical data in order to reflect the local population at high risk for developing cardiovascular diseas. The model was tested on a high risk population, formed by all acute myocardial infarction survivors in Italy, and indicated that life-long treatment of this patients would yield significant clinical benefits, with a cost/ effectiveness of 3,932 euro/year of life saved. This value is well below the standards that are considered acceptable, and offsprings from the partial offset of pharmaceutical costs caused by the reduction in the expenses for diagnosis and treatment of the cardiovascular events

  19. Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex

    Science.gov (United States)

    Yang, Jin; Feng, Xuhui; Zhou, Qiong; Cheng, Wei; Shang, Ching; Han, Pei; Lin, Chiou-Hong; Chen, Huei-Sheng Vincent; Quertermous, Thomas; Chang, Ching-Pin

    2016-01-01

    Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of angiotensin II that promotes cardiac hypertrophy and fibrosis. The regulatory mechanism that underlies the Ace2-to-Ace pathological switch, however, is unknown. Here we report that the Brahma-related gene-1 (Brg1) chromatin remodeler and forkhead box M1 (FoxM1) transcription factor cooperate within cardiac (coronary) endothelial cells of pathologically stressed hearts to trigger the Ace2-to-Ace enzyme switch, angiotensin I-to-II conversion, and cardiac hypertrophy. In mice, cardiac stress activates the expression of Brg1 and FoxM1 in endothelial cells. Once activated, Brg1 and FoxM1 form a protein complex on Ace and Ace2 promoters to concurrently activate Ace and repress Ace2, tipping the balance to Ace2 expression with enhanced angiotensin II production, leading to cardiac hypertrophy and fibrosis. Disruption of endothelial Brg1 or FoxM1 or chemical inhibition of FoxM1 abolishes the stress-induced Ace2-to-Ace switch and protects the heart from pathological hypertrophy. In human hypertrophic hearts, BRG1 and FOXM1 expression is also activated in endothelial cells; their expression levels correlate strongly with the ACE/ACE2 ratio, suggesting a conserved mechanism. Our studies demonstrate a molecular interaction of Brg1 and FoxM1 and an endothelial mechanism of modulating Ace/Ace2 ratio for heart failure therapy. PMID:27601681

  20. Integrating uncertainties to the combined environmental and economic assessment of algal biorefineries: A Monte Carlo approach.

    Science.gov (United States)

    Pérez-López, Paula; Montazeri, Mahdokht; Feijoo, Gumersindo; Moreira, María Teresa; Eckelman, Matthew J

    2018-06-01

    The economic and environmental performance of microalgal processes has been widely analyzed in recent years. However, few studies propose an integrated process-based approach to evaluate economic and environmental indicators simultaneously. Biodiesel is usually the single product and the effect of environmental benefits of co-products obtained in the process is rarely discussed. In addition, there is wide variation of the results due to inherent variability of some parameters as well as different assumptions in the models and limited knowledge about the processes. In this study, two standardized models were combined to provide an integrated simulation tool allowing the simultaneous estimation of economic and environmental indicators from a unique set of input parameters. First, a harmonized scenario was assessed to validate the joint environmental and techno-economic model. The findings were consistent with previous assessments. In a second stage, a Monte Carlo simulation was applied to evaluate the influence of variable and uncertain parameters in the model output, as well as the correlations between the different outputs. The simulation showed a high probability of achieving favorable environmental performance for the evaluated categories and a minimum selling price ranging from $11gal -1 to $106gal -1 . Greenhouse gas emissions and minimum selling price were found to have the strongest positive linear relationship, whereas eutrophication showed weak correlations with the other indicators (namely greenhouse gas emissions, cumulative energy demand and minimum selling price). Process parameters (especially biomass productivity and lipid content) were the main source of variation, whereas uncertainties linked to the characterization methods and economic parameters had limited effect on the results. Copyright © 2018 Elsevier B.V. All rights reserved.

  1. Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

    Directory of Open Access Journals (Sweden)

    Anna Iwaniak

    2009-01-01

    Full Text Available This paper presents a modern in silico approach useful in the evaluation of proteins as a source of ACE inhibitors. All protein sequences analyzed were derived from the BIOPEP database. To determine the protein value, the following criteria of evaluation were applied: the profile of potential biological (ACE inhibitory activity of a protein, the frequency of the occurrence of fragments with ACE inhibitory activity (A and the potential biological activity of a protein (B. The results, based on a statistical analysis, indicate that milk proteins can be a better source of ACE inhibitors than wheat gliadins. Moreover, all analyzed gliadins possessed more potent ACE inhibitors than chicken meat proteins. No significant differences were observed when comparing A values between soy globulins and β-lactoglobulins. Although criteria such as the profile of potential biological activity of protein, as well as parameters A and B, can be suitable tools in protein evaluation, the proteolytic digestion of protein needs to be considered. Moreover, computerised methods of classifying proteins according to different algorithms are often subjective due to discretion in interpretation of the results.

  2. Intellectual capital: approaches to analysis as an object of the internal environment of an economic entity

    Directory of Open Access Journals (Sweden)

    O. E. Ustinova

    2017-01-01

    Full Text Available Intellectual capital is of strategic importance for a modern company. At the same time, its effective management, including a stimulating and creative approach to solving problems, will help to increase the competitiveness and development of economic entities. The article considers intellectual capital as an object of analysis of the internal environment. In the context of the proposed approaches to its study, its impact on the development of the company is also considered. The intellectual capital has a special significance and influence on internal processes, since on each of them the intellectual component allows to achieve a positive synergetic effect from the interaction of different objects. In more detail, it is proposed to consider it in terms of the position of the company it occupies on the market, the principles of its activities, the formation of marketing policies, the use of resources, methods and means of making managerial decisions, and the organizational culture formed. For the analysis of the state of the internal environment, the main approaches are proposed, in which the intellectual capital is considered, among them: methods for analyzing cash flows, economic efficiency and financial feasibility of the project, analysis of the consolidated financial flow by group of objects, assessment of the potential of the business entity, technology of choice of investment policy, technology Selection of incentive mechanisms. In this regard, it is advisable to analyze the company's internal environment from the position of influencing its state of intellectual capital. The scheme of interaction of intellectual capital and objects of an estimation of an internal environment of the managing subject is offered. The results of this study should be considered as initial data for the further development of the economic evaluation of the influence of intellectual capital on the competitiveness of companies.

  3. Identifying best-fitting inputs in health-economic model calibration: a Pareto frontier approach.

    Science.gov (United States)

    Enns, Eva A; Cipriano, Lauren E; Simons, Cyrena T; Kong, Chung Yin

    2015-02-01

    To identify best-fitting input sets using model calibration, individual calibration target fits are often combined into a single goodness-of-fit (GOF) measure using a set of weights. Decisions in the calibration process, such as which weights to use, influence which sets of model inputs are identified as best-fitting, potentially leading to different health economic conclusions. We present an alternative approach to identifying best-fitting input sets based on the concept of Pareto-optimality. A set of model inputs is on the Pareto frontier if no other input set simultaneously fits all calibration targets as well or better. We demonstrate the Pareto frontier approach in the calibration of 2 models: a simple, illustrative Markov model and a previously published cost-effectiveness model of transcatheter aortic valve replacement (TAVR). For each model, we compare the input sets on the Pareto frontier to an equal number of best-fitting input sets according to 2 possible weighted-sum GOF scoring systems, and we compare the health economic conclusions arising from these different definitions of best-fitting. For the simple model, outcomes evaluated over the best-fitting input sets according to the 2 weighted-sum GOF schemes were virtually nonoverlapping on the cost-effectiveness plane and resulted in very different incremental cost-effectiveness ratios ($79,300 [95% CI 72,500-87,600] v. $139,700 [95% CI 79,900-182,800] per quality-adjusted life-year [QALY] gained). Input sets on the Pareto frontier spanned both regions ($79,000 [95% CI 64,900-156,200] per QALY gained). The TAVR model yielded similar results. Choices in generating a summary GOF score may result in different health economic conclusions. The Pareto frontier approach eliminates the need to make these choices by using an intuitive and transparent notion of optimality as the basis for identifying best-fitting input sets. © The Author(s) 2014.

  4. Comparing the economic and health benefits of different approaches to diagnosing Clostridium difficile infection.

    Science.gov (United States)

    Bartsch, Sarah M; Umscheid, Craig A; Nachamkin, Irving; Hamilton, Keith; Lee, Bruce Y

    2015-01-01

    Accurate diagnosis of Clostridium difficile infection (CDI) is essential to effectively managing patients and preventing transmission. Despite the availability of several diagnostic tests, the optimal strategy is debatable and their economic values are unknown. We modified our previously existing C. difficile simulation model to determine the economic value of different CDI diagnostic approaches from the hospital perspective. We evaluated four diagnostic methods for a patient suspected of having CDI: 1) toxin A/B enzyme immunoassay, 2) glutamate dehydrogenase (GDH) antigen/toxin AB combined in one test, 3) nucleic acid amplification test (NAAT), and 4) GDH antigen/toxin AB combination test with NAAT confirmation of indeterminate results. Sensitivity analysis varied the proportion of those tested with clinically significant diarrhoea, the probability of CDI, NAAT cost and CDI treatment delay resulting from a false-negative test, length of stay and diagnostic sensitivity and specificity. The GDH/toxin AB plus NAAT approach leads to the timeliest treatment with the fewest unnecessary treatments given, resulted in the best bed management and generated the lowest cost. The NAAT-alone approach also leads to timely treatment. The GDH/toxin AB diagnostic (without NAAT confirmation) approach resulted in a large number of delayed treatments, but results in the fewest secondary colonisations. Results were robust to the sensitivity analysis. Choosing the right diagnostic approach is a matter of cost and test accuracy. GDH/toxin AB plus NAAT diagnosis led to the timeliest treatment and was the least costly. Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  5. Chaotic artificial immune approach applied to economic dispatch of electric energy using thermal units

    International Nuclear Information System (INIS)

    Santos Coelho, Leandro dos; Mariani, Viviana Cocco

    2009-01-01

    The economic dispatch problem (EDP) is an optimization problem useful in power systems operation. The objective of the EDP of electric power generation, whose characteristics are complex and highly non-linear, is to schedule the committed generating unit outputs so as to meet the required load demand at minimum operating cost while satisfying system constraints. Recently, as an alternative to the conventional mathematical approaches, modern heuristic optimization techniques have been given much attention by many researchers due to their ability to find an almost global optimal solution in EDPs. As special mechanism to avoid being trapped in local minimum, the ergodicity property of chaotic sequences has been used as optimization technique in EDPs. Based on the chaos theory, this paper discusses the design and validation of an optimization procedure based on a chaotic artificial immune network approach based on Zaslavsky's map. The optimization approach based on chaotic artificial immune network is validated for a test system consisting of 13 thermal units whose incremental fuel cost function takes into account the valve-point loading effects. Simulation results and comparisons show that the chaotic artificial immune network approach is competitive in performance with other optimization approaches presented in literature and is also an attractive tool to be used on applications in the power systems field.

  6. Peripheral artery disease: potential role of ACE-inhibitor therapy

    Directory of Open Access Journals (Sweden)

    Giuseppe Coppola

    2008-12-01

    Full Text Available Giuseppe Coppola, Giuseppe Romano, Egle Corrado, Rosa Maria Grisanti, Salvatore NovoDepartment of Internal Medicine, Cardiovascular and Nephro-Urological Diseases, Chair of Cardiovascular Disease, University of Palermo, Palermo, ItalyAbstract: Subjects with peripheral arterial disease (PAD of the lower limbs are at high risk for cardiovascular and cerebrovascular events and the prevalence of coronary artery disease in such patients is elevated. Recent studies have shown that regular use of cardiovascular medications, such as therapeutic and preventive agents for PAD patients, seems to be promising in reducing long-term mortality and morbidity. The angiotensin-converting-enzyme (ACE system plays an important role in the pathogenesis and progression of atherosclerosis, and ACE-inhibitors (ACE-I seem to have vasculoprotective and antiproliferative effects as well as a direct antiatherogenic effect. ACE-I also promote the degradation of bradykinin and the release of nitric oxide, a potent vasodilator; further, thay have shown important implications for vascular oxidative stress. Other studies have suggested that ACE-I may also improve endothelial dysfunction. ACE-I are useful for reducing the risk of cardiovascular events in clinical and subclinical PAD. Particularly, one agent of the class (ie, ramipril has shown in many studies to able to significantly reduce cardiovascular morbidity and mortality in patients with PAD.Keywords: atherosclerosis, peripheral arterial disease, endothelial dysfunction, ACE-inhibitors

  7. Silencing of HaAce1 gene by host-delivered artificial microRNA disrupts growth and development of Helicoverpa armigera.

    Science.gov (United States)

    Saini, Ravi Prakash; Raman, Venkat; Dhandapani, Gurusamy; Malhotra, Era Vaidya; Sreevathsa, Rohini; Kumar, Polumetla Ananda; Sharma, Tilak R; Pattanayak, Debasis

    2018-01-01

    The polyphagous insect-pest, Helicoverpa armigera, is a serious threat to a number of economically important crops. Chemical application and/or cultivation of Bt transgenic crops are the two strategies available now for insect-pest management. However, environmental pollution and long-term sustainability are major concerns against these two options. RNAi is now considered as a promising technology to complement Bt to tackle insect-pests menace. In this study, we report host-delivered silencing of HaAce1 gene, encoding the predominant isoform of H. armigera acetylcholinesterase, by an artificial microRNA, HaAce1-amiR1. Arabidopsis pre-miRNA164b was modified by replacing miR164b/miR164b* sequences with HaAce1-amiR1/HaAce1-amiR1* sequences. The recombinant HaAce1-preamiRNA1 was put under the control of CaMV 35S promoter and NOS terminator of plant binary vector pBI121, and the resultant vector cassette was used for tobacco transformation. Two transgenic tobacco lines expressing HaAce1-amiR1 was used for detached leaf insect feeding bioassays. Larval mortality of 25% and adult deformity of 20% were observed in transgenic treated insect group over that control tobacco treated insect group. The reduction in the steady-state level of HaAce1 mRNA was 70-80% in the defective adults compared to control. Our results demonstrate promise for host-delivered amiRNA-mediated silencing of HaAce1 gene for H. armigera management.

  8. The Conceptual Approaches to Strategic Management of Region Using the Spatially Localized Agrarian Economic Systems

    Directory of Open Access Journals (Sweden)

    Petrenko Natalia О.

    2017-10-01

    Full Text Available The article is aimed at improving the theoretical and methodical provisions of the cluster approach to development of the spatially localized systems of the agricultural sector of Ukrainian economy at the regional level. Based on generalizing the relevant theoretical provisions, the identified characteristics of formation and development of the spatially localized systems, it has been found that, originating in the form of economic growth zones, they have been transformed into clustered and subclustered forms. It has been indicated that a prospective form of further development of the spatially localized systems is formation of subclustered structures that take account of the established specialization of localities, appropriate infrastructure, resource availability. The possibility of creating a project of developing a cluster formation was discussed on the example of the Central Economic Area. A complex of basic requirements for the intended localization of the cluster has been formulated. Proceeding from the results of the study, practical proposals for strategic management of region have been developed on the basis of development of cluster formations, using the spatially localized agrarian economic systems.

  9. Estimating the Relationship between Economic Growth and Health Expenditures in ECO Countries Using Panel Cointegration Approach

    Directory of Open Access Journals (Sweden)

    Nahid Hatam

    2016-03-01

    Full Text Available Increasing knowledge of people about health leads to raising the share of health expenditures in government budget continuously; although governors do not like this rise because of budget limitations. This study aimed to find the association between health expenditures and economic growth in ECO countries. We added health capital in Solow model and used the panel cointegration approach to show the importance of health expenditures in economic growth. For estimating the model, first we used Pesaran cross-sectional dependency test, after that we used Pesaran CADF unit root test, and then we used Westerlund panel cointegration test to show if there is a long-term association between variables or not. After that, we used chaw test, Breusch-Pagan test and Hausman test to find the form of the model. Finally, we used OLS estimator for panel data. Findings showed that there is a positive, strong association between health expenditures and economic growth in ECO countries. If governments increase investing in health, the total production of the country will be increased, so health expenditures are considered as an investing good. The effects of health expenditures in developing countries must be higher than those in developed countries. Such studies can help policy makers to make long-term decisions.

  10. Estimating the Relationship between Economic Growth and Health Expenditures in ECO Countries Using Panel Cointegration Approach.

    Science.gov (United States)

    Hatam, Nahid; Tourani, Sogand; Homaie Rad, Enayatollah; Bastani, Peivand

    2016-02-01

    Increasing knowledge of people about health leads to raising the share of health expenditures in government budget continuously; although governors do not like this rise because of budget limitations. This study aimed to find the association between health expenditures and economic growth in ECO countries. We added health capital in Solow model and used the panel cointegration approach to show the importance of health expenditures in economic growth. For estimating the model, first we used Pesaran cross-sectional dependency test, after that we used Pesaran CADF unit root test, and then we used Westerlund panel cointegration test to show if there is a long-term association between variables or not. After that, we used chaw test, Breusch-Pagan test and Hausman test to find the form of the model. Finally, we used OLS estimator for panel data. Findings showed that there is a positive, strong association between health expenditures and economic growth in ECO countries. If governments increase investing in health, the total production of the country will be increased, so health expenditures are considered as an investing good. The effects of health expenditures in developing countries must be higher than those in developed countries. Such studies can help policy makers to make long-term decisions.

  11. A meta-analysis of the accuracy of the Addenbrooke's Cognitive Examination (ACE) and the Addenbrooke's Cognitive Examination-Revised (ACE-R) in the detection of dementia.

    Science.gov (United States)

    Larner, Andrew J; Mitchell, Alex J

    2014-04-01

    The Addenbrooke's Cognitive Examination (ACE) and its Revised version (ACE-R) are relatively new screening tools for cognitive impairment that may improve upon the well-known Mini-Mental State Examination (MMSE) and other brief batteries. We systematically reviewed diagnostic accuracy studies of ACE and ACE-R. Published studies comparing ACE, ACE-R and MMSE were comprehensively sought and critically appraised. A meta-analysis of suitable studies was conducted. Of 61 possible publications identified, meta-analysis of qualifying studies encompassed 5 for ACE (1,090 participants) and 5 for ACE-R (1156 participants); of these, 9 made direct comparisons with the MMSE. Sensitivity and specificity of the ACE were 96.9% (95% CI = 92.7% to 99.4%) and 77.4% (95% CI = 58.3% to 91.8%); and for the ACE-R were 95.7% (95% CI = 92.2% to 98.2%) and 87.5% (95% CI = 63.8% to 99.4%). In a modest prevalence setting, such as primary care or general hospital settings where the prevalence of dementia may be approximately 25%, overall accuracy of the ACE (0.823) was inferior to ACE-R (0.895) and MMSE (0.882). In high prevalence settings such as memory clinics where the prevalence of dementia may be 50% or higher, overall accuracy again favored ACE-R (0.916) over ACE (0.872) and MMSE (0.895). The ACE-R has somewhat superior diagnostic accuracy to the MMSE while the ACE appears to have inferior accuracy. The ACE-R is recommended in both modest and high prevalence settings. Accuracy of newer versions of the ACE remain to be determined.

  12. Modified economic order quantity (EOQ model for items with imperfect quality: Game-theoretical approaches

    Directory of Open Access Journals (Sweden)

    Milad Elyasi

    2014-04-01

    Full Text Available In the recent decade, studying the economic order quantity (EOQ models with imperfect quality has appealed to many researchers. Only few papers are published discussing EOQ models with imperfect items in a supply chain. In this paper, a two-echelon decentralized supply chain consisting of a manufacture and a supplier that both face just in time (JIT inventory problem is considered. It is sought to find the optimal number of the shipments and the quantity of each shipment in a way that minimizes the both manufacturer’s and the supplier’s cost functions. To the authors’ best knowledge, this is the first paper that deals with imperfect items in a decentralized supply chain. Thereby, three different game theoretical solution approaches consisting of two non-cooperative games and a cooperative game are proposed. Comparing the results of three different scenarios with those of the centralized model, the conclusions are drawn to obtain the best approach.

  13. Planning and management for health in periods of economic stringency and instability: a contingency approach.

    Science.gov (United States)

    van der Werff, A

    1986-01-01

    The mid-1970s marked the end of the longest period of uninterrupted economic growth in history, and initiated in Europe--and other parts of the world--a period of economic stagnation and instability. Along with the prosperity explosion of the past, the pattern of health problems has changed and is still changing. Moreover, the demand for health care has kept on rising, without much improvement of health status in general. Thus, there is a critical need to rethink policies, and to ensure that future changes occur within the limits of shrinking resources and the allotted time-span. In particular, the change in priorities envisaged by the Health for All 2000 (HFA 2000) strategies will need to take place against the background of an ageing population, social instability, and continuing development of new lifestyles and persistent economic scarcity. It is by analysing that background that this article seeks to make recommendations as to how health planning and management might successfully cope with the policy reorientation of the HFA 2000 strategy. The structure of this article is as follows. Firstly, the changes taking place in planning conditions will be reviewed, and form the basis of a framework for subsequent analysis of the planning environment. Following this framework, some of the conflicts likely to be faced in planning and management will be discussed, many of which are the consequence of economic stringency and instability. Also the requirements for an improvement of the effectiveness and efficiency of planning will be identified. Finally, a limited number of approaches to planning will be considered, for their appropriateness to the present-day economic circumstances. The point of view elucidated throughout is that there is no single solution which is 'best' under all circumstances. The conclusion, rather, is that the selection of particular theory or method of planning and management should depend both on the objectives of the decision maker and on the

  14. New approaches in teaching the discipline of «Labor protection» at the University of Economics

    OpenAIRE

    Гончаров, В. А.; Самойлов, М. В.

    2013-01-01

    The report provides a comparison of different models of education for university students on the issues of labor protection. New approaches to teaching discipline of «Labor protection» at the University of Economics are considered.

  15. Fuzzy logic approach for energetic and economic evaluation of hydroelectric projects

    International Nuclear Information System (INIS)

    Iliev, Atanas M.

    2003-01-01

    A mathematical model for energetic and economic evaluation of hydroelectric projects is developed. The main advantage of the proposed methodology is that the model considers uncertainty and vagueness which appears during the decision making process. Due to modeling of variables that are non statistical in their character, fuzzy logic approach is fully incorporated in the model. The first step in energetic evaluation of the hydro power projects is determination of the characteristic of the efficiency of the units to be installed in hydro power plants. For this purpose the model which uses the best characteristics of Artificial Network Fuzzy Inference System (ANFIS) is applied. The method is tested on real systems: HPP Tikves- the power plant in operation and HPP Kozjak - the power plant in construction. The results obtained from practical implementation show that the proposed approach gives superior results than classical polynomial approximation. The model for determining the consumption characteristic of hydro power plant is developed by Sugeno Fuzzy Logic System with polynomials in the consequent part of the rules. Model takes into account the variable gross head of HPP, as well as, the number of units which will be in operation for given output. Modeling of the gross head and power output are performed by expert's design membership functions. This model is practically applied on HPP Tikves for determination of the consumption characteristic for several gross head. The plausible yearly production of electricity from hydro power project, which is important for estimation of the benefit from the project, is calculated by mixed fuzzy-statistical model. hi this approach fuzzy set of the inflow is constructed according to the statistical parameters. The calculation of the production of electricity is realized for a several hydrological conditions which are described by linguistic variables. Finally, Mamdani Fuzzy Inference System with fuzzy number in consequent part

  16. AceCloud: Molecular Dynamics Simulations in the Cloud.

    Science.gov (United States)

    Harvey, M J; De Fabritiis, G

    2015-05-26

    We present AceCloud, an on-demand service for molecular dynamics simulations. AceCloud is designed to facilitate the secure execution of large ensembles of simulations on an external cloud computing service (currently Amazon Web Services). The AceCloud client, integrated into the ACEMD molecular dynamics package, provides an easy-to-use interface that abstracts all aspects of interaction with the cloud services. This gives the user the experience that all simulations are running on their local machine, minimizing the learning curve typically associated with the transition to using high performance computing services.

  17. Nicotine reduction as an increase in the unit price of cigarettes: a behavioral economics approach.

    Science.gov (United States)

    Smith, Tracy T; Sved, Alan F; Hatsukami, Dorothy K; Donny, Eric C

    2014-11-01

    Urgent action is needed to reduce the harm caused by smoking. Product standards that reduce the addictiveness of cigarettes are now possible both in the U.S. and in countries party to the Framework Convention on Tobacco Control. Specifically, standards that required substantially reduced nicotine content in cigarettes could enable cessation in smokers and prevent future smoking among current non-smokers. Behavioral economics uses principles from the field of microeconomics to characterize how consumption of a reinforcer changes as a function of the unit price of that reinforcer (unit price=cost/reinforcer magnitude). A nicotine reduction policy might be considered an increase in the unit price of nicotine because smokers are paying more per unit of nicotine. This perspective allows principles from behavioral economics to be applied to nicotine reduction research questions, including how nicotine consumption, smoking behavior, use of other tobacco products, and use of other drugs of abuse are likely to be affected. This paper reviews the utility of this approach and evaluates the notion that a reduction in nicotine content is equivalent to a reduction in the reinforcement value of smoking-an assumption made by the unit price approach. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Transparency in European banking system – a technical and economic approach

    Directory of Open Access Journals (Sweden)

    Ștefănescu Cristina Alexandrina

    2014-03-01

    Full Text Available The objective of our paper is to provide a comprehensive analysis of possible relationships between two different approaches of “transparency” – the technical vs. the economic one. Thus, irrespective of prior literature, our paper goes beyond a “solo” analysis of either of two above-mentioned “facets”, by providing a combined study. So, we focused on both (1 XBRL’s role in enhancing the quality of disclosure, by assessing its benefices and consequences and (2 corporate governance mechanism’s power to improve efficiency and effectiveness of banking supervision by encouraging transparency. The results of the performed analysis generally reveal that there is a strong and positive relationship between the level of disclosure promoted by corporate governance codes enforced in European Union countries and the degree of implementation of both XBRL-based projects designed for banking environment (FINREP and COREP. Consequently, we can assert that there is a consensus between the economic and technical approach of transparency in European banking system

  19. Equitable fund allocation, an economical approach for sustainable waste load allocation.

    Science.gov (United States)

    Ashtiani, Elham Feizi; Niksokhan, Mohammad Hossein; Jamshidi, Shervin

    2015-08-01

    This research aims to study a novel approach for waste load allocation (WLA) to meet environmental, economical, and equity objectives, simultaneously. For this purpose, based on a simulation-optimization model developed for Haraz River in north of Iran, the waste loads are allocated according to discharge permit market. The non-dominated solutions are initially achieved through multiobjective particle swarm optimization (MOPSO). Here, the violation of environmental standards based on dissolved oxygen (DO) versus biochemical oxidation demand (BOD) removal costs is minimized to find economical total maximum daily loads (TMDLs). This can save 41% in total abatement costs in comparison with the conventional command and control policy. The BOD discharge permit market then increases the revenues to 45%. This framework ensures that the environmental limits are fulfilled but the inequity index is rather high (about 4.65). For instance, the discharge permit buyer may not be satisfied about the equity of WLA. Consequently, it is recommended that a third party or institution should be in charge of reallocating the funds. It means that the polluters which gain benefits by unfair discharges should pay taxes (or funds) to compensate the losses of other polluters. This intends to reduce the costs below the required values of the lowest inequity index condition. These compensations of equitable fund allocation (EFA) may help to reduce the dissatisfactions and develop WLA policies. It is concluded that EFA in integration with water quality trading (WQT) is a promising approach to meet the objectives.

  20. LOGISTICAL APPROACHES TO IMPROVE THE MANAGEMENT OF PRODUCTION AND ECONOMIC ACTIVITIES OF BUSINESS ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    A. S. Senin

    2016-01-01

    Full Text Available This article sets out the key aspects of the management of enterprise structures on the basis of logistizatsii, which allowed to establish a close relationship between the main processes (production, and provide processes (procurement, sales, ie introduce the implementation of these processes as a whole. The purpose / goal. The purpose of the work is to study the nature and characteristics of the organizational-economic mechanism of production and economic activity of enterprise structures on the basis of the logistical approach, identifying the problems and prospects of further development.Methodology. In this article we used a set of general scientific and special methods of investigation. General scientific research methods (analysis and synthesis revealed a dynamic and structural specifics of the development of the global logistics market, to determine the future direction of development. Special investigation techniques (forecasting and modeling have allowed to develop a set of recommendations aimed at increasing the level of innovation activity of logistic operators in line with global trends and immutable proposed changes in consumer demand in key market segments.Results. As part of the presentation of the present article the author has examined the nature, objectives and business structures control stages with the use of modern logistics approach.

  1. Approach to increasing techno-economic effects of ventilation in uranium mines

    International Nuclear Information System (INIS)

    Zhou Xinhuo

    1989-01-01

    The main factors affecting techno-economic effects of ventilation in uranium mines are discussed in this paper. Under the conditions of technical feasibility and economic rationality, the method of economic analysis for ventilation and radiation protection in uranium mines is proposed. The technically feasible and economically reasonable suggestions are presented for increasing the techno-economic effects of ventilation in uranium mines

  2. Dynamic ecological-economic modeling approach for management of shellfish aquaculture

    CSIR Research Space (South Africa)

    Nobre, AM

    2008-02-01

    Full Text Available The objective of this report is to conceptualize ecological and economic interactions in mariculture; to implement a dynamic ecological-economic model in order to: simulate the socio-economics of aquaculture production, simulate its effects...

  3. Formation of an Approach to the Clustered Management of Foreign Economic Activity of Enterprises in the Conditions of Global Competition

    Directory of Open Access Journals (Sweden)

    Sushchenko Olena A.

    2015-09-01

    Full Text Available The article is aimed at formation of an approach to the clustered management of foreign economic activity of enterprises in the conditions of global competition. Expedience of use of the cluster approach in the field of management of foreign economic activity of enterprises has been substantiated. A basic framework has been developed and a cluster model for management of foreign economic activity of enterprises providing a description of such management as a complex mechanism with the specified parameters has been created. The basic elements of the cluster model of management of foreign economic activity of enterprise have been allocated. Purposes for selecting elemental clusters in the process of management of foreign economic activity of enterprise have been defined. The partial functions of management that display the functional purpose of the cluster model of management of foreign economic activity of enterprises, as well as the composition of its elements, have been allocated. A generalized hierarchical view of the cluster model of management of foreign economic activity of enterprises has been proposed. A scheme of the operational administration of functioning of the cluster model of management of foreign economic activity of enterprises, based on the core principles and basics of situational simulation, has been presented. Effectiveness of the presented management model is determined by the increasing share of enterprises in the external markets in the context of the relevant clusters, an expansion of the types of foreign economic activity of enterprises, implementation of innovations

  4. A hybrid agent-based computational economics and optimization approach for supplier selection problem

    Directory of Open Access Journals (Sweden)

    Zahra Pourabdollahi

    2017-12-01

    Full Text Available Supplier evaluation and selection problem is among the most important of logistics decisions that have been addressed extensively in supply chain management. The same logistics decision is also important in freight transportation since it identifies trade relationships between business establishments and determines commodity flows between production and consumption points. The commodity flows are then used as input to freight transportation models to determine cargo movements and their characteristics including mode choice and shipment size. Various approaches have been proposed to explore this latter problem in previous studies. Traditionally, potential suppliers are evaluated and selected using only price/cost as the influential criteria and the state-of-practice methods. This paper introduces a hybrid agent-based computational economics and optimization approach for supplier selection. The proposed model combines an agent-based multi-criteria supplier evaluation approach with a multi-objective optimization model to capture both behavioral and economical aspects of the supplier selection process. The model uses a system of ordered response models to determine importance weights of the different criteria in supplier evaluation from a buyers’ point of view. The estimated weights are then used to calculate a utility for each potential supplier in the market and rank them. The calculated utilities are then entered into a mathematical programming model in which best suppliers are selected by maximizing the total accrued utility for all buyers and minimizing total shipping costs while balancing the capacity of potential suppliers to ensure market clearing mechanisms. The proposed model, herein, was implemented under an operational agent-based supply chain and freight transportation framework for the Chicago Metropolitan Area.

  5. Advanced Course in Engineering (ACE) - Cyber Security Boot Camp

    National Research Council Canada - National Science Library

    Older, Susan

    2008-01-01

    .... ACE achieved its stated objectives by completely immersing students in the cyber-security discipline for ten weeks, through a combination of intense coursework, open-ended problems, and internship...

  6. Another look at economic approaches to environmental management and policy with reference to developments in South Africa

    Directory of Open Access Journals (Sweden)

    Martin De Wit

    2016-12-01

    Full Text Available The wide acceptance of economic approaches to environmental management and policy, masks increasing heterogeneity in the field. This editorial addresses the question whether the economic approach is still warranted and under which conditions. A broad outline of the trends in both orthodox and heterodox economic approaches is also presented. The traditional split between environmental and ecological economics is not doing justice to recent developments in the field. Instead it is proposed to rather refer to Environmental, Resource and Ecological Economics (EREE, Ecological-Economic Systems (EES and Socio-Ecological Systems (SES approaches as well as Heterodox approaches to Environment and Sustainability (HEES. The contributions made to this special issue are placed within their respective subfields of influence. It is concluded that a deeper, self-critical exposition of moral philosophies and values as well as models of reality are needed. A strategy of engagement in an attitude of self-criticism, humility and in participation with others is proposed as a viable way forward. For such a process to be successful two conditions are required, namely valuing the human person and accepting the reality of a nondeterminate world full of meaning.

  7. CONCEPTUAL APPROACHES TO STUDY THE INNOVATIVE DEVELOPMENT OF REGIONAL SOCIO-ECONOMIC SYSTEMS

    Directory of Open Access Journals (Sweden)

    Svitlana Fedulova

    2017-12-01

    Full Text Available The purpose of the paper is to find out and identify conceptual approaches to the study of the innovative development of regional socio-economic systems to take into account global requirements for global water security. Methodology. We used in our study traditional and special methods, including: historical and logical method, abstraction and analogy, and system analysis methods. Results. The article deals with the problems of innovative development of regional socio-economic systems. Conceptual approaches to the study of the innovative development of these systems are determined. Theoretical approaches to regionalization are generalized and the regional typology in world regionalism is presented. The study devotes a sufficient attention to the issues of infrastructure support for regional systems, which is a prerequisite for the functioning and development of such systems. The article focuses on the priority of research of such a component of regional infrastructure as engineering and technical infrastructure. The model of regulation of development of regional socio-economic systems on the basis of infrastructure support with the consideration of world requirements of global water security is offered. Practical implications. In recent times, the discussion on the definition of the essence of the concept of “region” is rather lively. The new paradigm of the regional economy represents the region as a variety of spatial systems of various scales. Yes, there are ongoing discussions that under the region can be understood as a group of states and small-sized administrative-territorial units. Despite the important role played by such regional systems in the economy of many countries, this topic in domestic studies is not given with enough attention. Also, in the domestic scientific schools of the regional economy, studies devoted to the problems of patterns and tendencies of the formation and development of regional systems of Ukraine, the

  8. A Hydro-Economic Approach to Representing Water Resources Impacts in Integrated Assessment Models

    Energy Technology Data Exchange (ETDEWEB)

    Kirshen, Paul H.; Strzepek, Kenneth, M.

    2004-01-14

    Grant Number DE-FG02-98ER62665 Office of Energy Research of the U.S. Department of Energy Abstract Many Integrated Assessment Models (IAM) divide the world into a small number of highly aggregated regions. Non-OECD countries are aggregated geographically into continental and multiple-continental regions or economically by development level. Current research suggests that these large scale aggregations cannot accurately represent potential water resources-related climate change impacts. In addition, IAMs do not explicitly model the flow regulation impacts of reservoir and ground water systems, the economics of water supply, or the demand for water in economic activities. Using the International Model for Policy Analysis of Agricultural Commodities and Trade (IMPACT) model of the International Food Policy Research Institute (IFPRI) as a case study, this research implemented a set of methodologies to provide accurate representation of water resource climate change impacts in Integrated Assessment Models. There were also detailed examinations of key issues related to aggregated modeling including: modeling water consumption versus water withdrawals; ground and surface water interactions; development of reservoir cost curves; modeling of surface areas of aggregated reservoirs for estimating evaporation losses; and evaluating the importance of spatial scale in river basin modeling. The major findings include: - Continental or national or even large scale river basin aggregation of water supplies and demands do not accurately capture the impacts of climate change in the water and agricultural sector in IAMs. - Fortunately, there now exist gridden approaches (0.5 X 0.5 degrees) to model streamflows in a global analysis. The gridded approach to hydrologic modeling allows flexibility in aligning basin boundaries with national boundaries. This combined with GIS tools, high speed computers, and the growing availability of socio-economic gridded data bases allows assignment of

  9. An Economic Evaluation on Replacement Plan for Aged Thermal Power Plants through a Real Option Approach

    Science.gov (United States)

    Kato, Moritoshi; Zhou, Yicheng

    This paper presents a novel method to evaluate replacement plan for aged thermal power plants under uncertain circumstances through a real option approach. The most economical plan is selected among the three options: an option to operate an existing oil-fired thermal plant, an option to mothball it, and an option to abandon it and to construct an advanced gas combined cycle power plant (ACC) at the same time. Basic ideas of our model are: we use quadranomial approach in order to evaluate an option value consisted by two different uncertain assets; we consider cash flow with a dividend in order to reflect conditions of an aged oil-fired thermal plant and use the sequential compound option approach; we evaluate replacement time using quadranomial decision tree taking into account the options. We also analyze value and time of replacement using numerical examples. Our proposed method will be practically used for generation planning. For example it is possible to make priority quantitatively in replacements of aged thermal power plants by real option values. The target year of replacement may be set as a year when cumulative probability of replacement becomes over certain level.

  10. The Capability Approach: A Critical Review of Its Application in Health Economics.

    Science.gov (United States)

    Karimi, Milad; Brazier, John; Basarir, Hasan

    The capability approach is an approach to assessing well-being developed by Amartya Sen. Interest in this approach has resulted in several attempts to develop questionnaires to measure and value capability at an individual level in health economics. This commentary critically reviews the ability of these questionnaires to measure and value capability. It is argued that the method used in the questionnaires to measure capability will result in a capability set that is an inaccurate description of the individual's true capability set. The measured capability set will either represent only one combination and ignore the value of choice in the capability set, or represent one combination that is not actually achievable by the individual. In addition, existing methods of valuing capability may be inadequate because they do not consider that capability is a set. It may be practically more feasible to measure and value capability approximately rather than directly. Suggestions are made on how to measure and value an approximation to capability, but further research is required to implement the suggestions. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  11. Evolution of the Theoretical Approaches to Disclosing the Economic Substance of Accumulation of Capital

    Directory of Open Access Journals (Sweden)

    Yemets Vadym V.

    2016-05-01

    Full Text Available The article proposes a classification for periods of evolution of theoretical approaches to disclosing the economic substance of accumulation of capital, taking into account the civilizational approach to the development of society. The author has proposed five stages in the evolution of theoretical approaches, which are closely related to the development of economy and stipulate dominance of a certain form of accumulation of capital. So, the first stage (time period B.C. – the 5th Century is referred to as Individual-social significance of accumulation of capital; the second stage (from the 6th century to the 16th century – Accumulation of monetary capitals; the third stage (from the mid-17th century until the end of the 18th century – Industrialproduction accumulation of capital; the fourth stage (from the mid-19th century until the 70s of the 20th century – Investment-oriented accumulation of capital; the fifth stage (from the 70s of the 20th century up to the current period – Globally-intensive accumulation of capital.

  12. Forecasting the global shortage of physicians: an economic- and needs-based approach

    Science.gov (United States)

    Liu, Jenny X; Kinfu, Yohannes; Dal Poz, Mario R

    2008-01-01

    Abstract Objective Global achievements in health may be limited by critical shortages of health-care workers. To help guide workforce policy, we estimate the future demand for, need for and supply of physicians, by WHO region, to determine where likely shortages will occur by 2015, the target date of the Millennium Development Goals. Methods Using World Bank and WHO data on physicians per capita from 1980 to 2001 for 158 countries, we employ two modelling approaches for estimating the future global requirement for physicians. A needs-based model determines the number of physicians per capita required to achieve 80% coverage of live births by a skilled health-care attendant. In contrast, our economic model identifies the number of physicians per capita that are likely to be demanded, given each country’s economic growth. These estimates are compared to the future supply of physicians projected by extrapolating the historical rate of increase in physicians per capita for each country. Findings By 2015, the global supply of physicians appears to be in balance with projected economic demand. Because our measure of need reflects the minimum level of workforce density required to provide a basic health service that is met in all but the least developed countries, the needs-based estimates predict a global surplus of physicians. However, on a regional basis, both models predict shortages for many countries in the WHO African Region in 2015, with some countries experiencing a needs-based shortage, a demand-based shortage, or both. Conclusion The type of policy intervention needed to alleviate projected shortages, such as increasing health-care training or adopting measures to discourage migration, depends on the type of shortage projected. PMID:18670663

  13. Environment contamination by mycotoxins and their occurrence in food and feed: Physiological aspects and economical approach.

    Science.gov (United States)

    Capcarova, Marcela; Zbynovska, Katarina; Kalafova, Anna; Bulla, Jozef; Bielik, Peter

    2016-01-01

    The contamination of food and feed by mycotoxins as toxic metabolites of fungi is a risk not only for consumers resulting in various embarrassment regarding health status and well-being, but also for producers, companies and export market on the ground of economic losses and ruined stability of economic trade. As it is given in historical evidence, the contamination of food by mycotoxins is a topic as old as a history of mankind, finding some evidence even in the ancient books and records. Nowadays, the mycotoxins are used in modern biotechnological laboratories and are considered an agent for targeting the specific cells (e.g., defected cells to eliminate them). However, this promising procedure is only the beginning. More concern is focused on mycotoxins as abiotic hazard agents. The dealing with them, systematic monitoring, and development of techniques for their elimination from agricultural commodities are worldwide issues concerning all countries. They can be found alone or in co-occurrence with other mycotoxins. Thus, this review aims to provide widened information regarding mycotoxins contamination in environment with the consequences on health of animals and humans. The inevitability for more data that correctly determine the risk points linked to mycotoxins occurrence and their specific reactions in the environment is demonstrated. This review includes various symptoms in animals and humans that result from mycotoxin exposure. For better understanding of mycotoxin's impact on animals, the sensitivities of various animal species to various mycotoxins are listed. Strategies for elimination and preventing the risks of mycotoxins contamination as well as economical approach are discussed. To complete the topic, some data from past as historical evidences are presented.

  14. Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach.

    Science.gov (United States)

    Desai, Kamal; Gupta, Swati B; Dubberke, Erik R; Prabhu, Vimalanand S; Browne, Chantelle; Mast, T Christopher

    2016-06-18

    Despite a large increase in Clostridium difficile infection (CDI) severity, morbidity and mortality in the US since the early 2000s, CDI burden estimates have had limited generalizability and comparability due to widely varying clinical settings, populations, or study designs. A decision-analytic model incorporating key input parameters important in CDI epidemiology was developed to estimate the annual number of initial and recurrent CDI cases, attributable and all-cause deaths, economic burden in the general population, and specific number of high-risk patients in different healthcare settings and the community in the US. Economic burden was calculated adopting a societal perspective using a bottom-up approach that identified healthcare resources consumed in the management of CDI. Annually, a total of 606,058 (439,237 initial and 166,821 recurrent) episodes of CDI were predicted in 2014: 34.3 % arose from community exposure. Over 44,500 CDI-attributable deaths in 2014 were estimated to occur. High-risk susceptible individuals representing 5 % of the total hospital population accounted for 23 % of hospitalized CDI patients. The economic cost of CDI was $5.4 billion ($4.7 billion (86.7 %) in healthcare settings; $725 million (13.3 %) in the community), mostly due to hospitalization. A modeling framework provides more comprehensive and detailed national-level estimates of CDI cases, recurrences, deaths and cost in different patient groups than currently available from separate individual studies. As new treatments for CDI are developed, this model can provide reliable estimates to better focus healthcare resources to those specific age-groups, risk-groups, and care settings in the US where they are most needed. (Trial Identifier ClinicaTrials.gov: NCT01241552).

  15. Molecular and recombinational mapping of mutations in the Ace locus of Drosophila melanogaster

    International Nuclear Information System (INIS)

    Nagoshi, R.N.; Gelbart, W.M.

    1987-01-01

    The Ace locus in Drosophila melanogaster is known to be the structural gene for acetylcholinesterase. Ace is located in a region of chromosome arm 3R which has been subjected to intensive genetic and molecular analysis. Previous deletion mapping studies have identified a 40-kb region with which the Ace gene resides. This report focuses on the further localization of Ace within this 40-kb interval. Within this region, selective fine structure recombinational analysis was employed to localize three recessive Ace lethals relative to unselected restriction site variations. These three mutations fall into a segment of 7 kb within the Ace interval. Fine structure recombinational analysis was also used to confirm that the Ace - phenotype of one deletion, Df(3R)Ace/sup HD1/, co-segregated with the molecular deletion. This deletion does not fully remove Ace activity, but it behaves as a recessive Ace lethal. Df(3R)Ace/sup HD1/ is the most distal Ace lesion identified and indicates that the Ace locus must extend at least 16 kb. Several poly(A)transcripts are detectable in the region defined by the Ace lesions. The position and extent of the Ace locus, as well as the types of transcripts found, is consistent with the recent findings which identified Torpedo-AChE homologous cDNA sequences in this region

  16. THE IMPACT OF CREDIT AND CAPITAL SUPPORTS ON ECONOMIC BEHAVIOR OF FARM HOUSEHOLDS: A HOUSEHOLD ECONOMIC APPROACH

    Directory of Open Access Journals (Sweden)

    Bernardus Bala de Rosari

    2014-07-01

    Full Text Available This research aimed at analysing the demand and allocation of credit and capital supports by farm household and impact on production, consumption, and investment. The research was conducted in East Nusa Tenggara Timur (ENT Province, one of targeted region of credit and capital supports policy of the government. Data collection was conducted from April to June 2013 by sampling for 178 households of farmers in Kupang District and Timor Tengah Selatan (TTS District. The result of this research showed that the allocation of credit and capital supports caused increaseof cattle production, consumption expenditure, and investment. The usage of credit and capital supports was depend on economical situation of the household itself. The decision of farm household on using credit and capital supports had impact on overall economical behavior of household, i.e. production, consumption and investment behavior. The transmission use was reciprocally interacted. Finally, the policy of credit and capital supports scheme for farmers should be adjusted with the context of farm household economics.

  17. Use of the Economic Approach in the Investigation of Criminal Gambling Services Market

    Directory of Open Access Journals (Sweden)

    Boris R. Avetisyan

    2016-09-01

    Full Text Available The high degree of development of the informal sector in the economy gives special importance on combating criminal markets, including the detection and suppression of illegal activities of criminal groups operating in the sector of gambling - an inexhaustible source of unregulated profits of their owners. Gambling creates conditions for committing crimes as the organizers and participants of gambling, allowing gambling include the so-called "background" phenomena of crime. The main reason for the "survivability" of gambling - the existence of strong demand for gambling on the part of players, according to the known laws of economics creates supply - organizing illegal gambling, which means that illegal gambling should be regarded as criminal market. This approach to the consideration of gambling has not only theoretical but also applied criminological importance in explaining the determination of the offenses (to the fore economic factors and improvement of prevention activities (it should be aimed at reducing the "demand" for gambling, and the elimination of " offers "illegal gambling services.

  18. Renewable energy consumption and economic growth in nine OECD countries: bounds test approach and causality analysis.

    Science.gov (United States)

    Hung-Pin, Lin

    2014-01-01

    The purpose of this paper is to investigate the short-run and long-run causality between renewable energy (RE) consumption and economic growth (EG) in nine OECD countries from the period between 1982 and 2011. To examine the linkage, this paper uses the autoregressive distributed lag (ARDL) bounds testing approach of cointegration test and vector error-correction models to test the causal relationship between variables. The co-integration and causal relationships are found in five countries-United States of America (USA), Japan, Germany, Italy, and United Kingdom (UK). The overall results indicate that (1) a short-run unidirectional causality runs from EG to RE in Italy and UK; (2) long-run unidirectional causalities run from RE to EG for Germany, Italy, and UK; (3) a long-run unidirectional causality runs from EG to RE in USA, and Japan; (4) both long-run and strong unidirectional causalities run from RE to EG for Germany and UK; and (5) Finally, both long-run and strong unidirectional causalities run from EG to RE in only USA. Further evidence reveals that policies for renewable energy conservation may have no impact on economic growth in France, Denmark, Portugal, and Spain.

  19. Ageing and the economic life cycle: The National Transfer Accounts approach.

    Science.gov (United States)

    Temple, Jeromey B; Rice, James M; McDonald, Peter F

    2017-12-01

    To illustrate the use of National Transfer Accounts (NTA) for understanding ageing and the economic life cycle in Australia. The NTA methodology is applied utilising a range of unit record, demographic and administrative data sets from 1981 to 2010. During early and later life, total consumption (public and private) is greater than labour income. On a time series and cohort basis, we show that each successive generation has improved their level of well-being (as measured by consumption) relative to the previous years or previous cohorts from 1981 to 1982 onwards. We also show a substantial increase in labour income earned by mature age workers over this period. International comparisons show Australia to have consumption and labour income age profiles very similar to those of Canada but dissimilar to many other countries, driven by differences in demographic and policy settings. The NTA approach provides a powerful framework to track differences in the economic life cycle across age groups, across time, across cohorts and across countries. © 2017 AJA Inc.

  20. Integrating health economics modeling in the product development cycle of medical devices: a Bayesian approach.

    Science.gov (United States)

    Vallejo-Torres, Laura; Steuten, Lotte M G; Buxton, Martin J; Girling, Alan J; Lilford, Richard J; Young, Terry

    2008-01-01

    Medical device companies are under growing pressure to provide health-economic evaluations of their products. Cost-effectiveness analyses are commonly undertaken as a one-off exercise at the late stage of development of new technologies; however, the benefits of an iterative use of economic evaluation during the development process of new products have been acknowledged in the literature. Furthermore, the use of Bayesian methods within health technology assessment has been shown to be of particular value in the dynamic framework of technology appraisal when new information becomes available in the life cycle of technologies. In this study, we set out a methodology to adapt these methods for their application to directly support investment decisions in a commercial setting from early stages of the development of new medical devices. Starting with relatively simple analysis from the very early development phase and proceeding to greater depth of analysis at later stages, a Bayesian approach facilitates the incorporation of all available evidence and would help companies to make better informed choices at each decision point.

  1. Enhancing Sustainable Innovation by Design: an Approach to the Co-creation of Economic, Social and Environmental Value

    NARCIS (Netherlands)

    S. Rocchi

    2005-01-01

    textabstractThe thesis introduces a new, flexible and easy-to-use methodological design approach to envisioning product-service systems able to create economic value for business, as well as social and environmental benefits for society. Such an approach has been developed to support business

  2. Economic planning for electric energy systems: a multi objective linearized approach for solution

    International Nuclear Information System (INIS)

    Mata Medeiros Branco, T. da.

    1986-01-01

    The economic planning problem associated to the expansion and operation of electrical power systems is considered in this study, represented for a vectorial objective function in which the minimization of resources involved and maximization of attended demand constitute goals to be satisfied. Supposing all the variables involved with linear characteristic and considering the conflict existing among the objectives to be achieved, in order to find a solution, a multi objective linearized approach is proposed. This approximation utilizes the compromise programming technique and linear programming methods. Generation and transmission are simultaneously considered into the optimization process in which associated losses and the capacity of each line are included. Illustrated examples are also presented with results discussed. (author)

  3. Keeping pace with ACE: are ACE inhibitors and angiotensin II type 1 receptor antagonists potential doping agents?

    Science.gov (United States)

    Wang, Pei; Fedoruk, Matthew N; Rupert, Jim L

    2008-01-01

    In the decade since the angiotensin-converting enzyme (ACE) gene was first proposed to be a 'human gene for physical performance', there have been numerous studies examining the effects of ACE genotype on physical performance phenotypes such as aerobic capacity, muscle function, trainability, and athletic status. While the results are variable and sometimes inconsistent, and corroborating phenotypic data limited, carriers of the ACE 'insertion' allele (the presence of an alu repeat element in intron 16 of the gene) have been reported to have higher maximum oxygen uptake (VO2max), greater response to training, and increased muscle efficiency when compared with individuals carrying the 'deletion' allele (absence of the alu repeat). Furthermore, the insertion allele has been reported to be over-represented in elite athletes from a variety of populations representing a number of endurance sports. The mechanism by which the ACE insertion genotype could potentiate physical performance is unknown. The presence of the ACE insertion allele has been associated with lower ACE activity (ACEplasma) in number of studies, suggesting that individuals with an innate tendency to have lower ACE levels respond better to training and are at an advantage in endurance sporting events. This could be due to lower levels of angiotensin II (the vasoconstrictor converted to active form by ACE), higher levels of bradykinin (a vasodilator degraded by ACE) or some combination of the two phenotypes. Observations that individuals carrying the ACE insertion allele (and presumably lower ACEplasma) have an enhanced response to training or are over-represented amongst elite athletes raises the intriguing question: would individuals with artificially lowered ACEplasma have similar training or performance potential? As there are a number of drugs (i.e. ACE inhibitors and angiotensin II type 1 receptor antagonists [angiotensin receptor blockers--ARBs]) that have the ability to either reduce ACEplasma

  4. Community Economics

    OpenAIRE

    武藤, 宣道; Nobumichi, MUTOH

    2000-01-01

    This paper examines the new field of community economics with respect to Japan. A number of studies in community economics have already been produced in OECD countries including the United States. Although these are of great interest, each country has its own historical, socioeconomic context and must therefore develop its own approach to community economics. Community-oriented economics is neither macro-nor micro-economics in the standard economics textbook sense. Most community economics st...

  5. Economic-environmental energy and reserve scheduling of smart distribution systems: A multiobjective mathematical programming approach

    International Nuclear Information System (INIS)

    Zakariazadeh, Alireza; Jadid, Shahram; Siano, Pierluigi

    2014-01-01

    Highlights: • Environmental/economical scheduling of energy and reserve. • Simultaneous participation of loads in both energy and reserve scheduling. • Aggregate wind generation and demand uncertainties in a stochastic model. • Stochastic scheduling of energy and reserve in a distribution system. • Demand response providers’ participation in energy and reserve scheduling. - Abstract: In this paper a stochastic multi-objective economical/environmental operational scheduling method is proposed to schedule energy and reserve in a smart distribution system with high penetration of wind generation. The proposed multi-objective framework, based on augmented ε-constraint method, is used to minimize the total operational costs and emissions and to generate Pareto-optimal solutions for the energy and reserve scheduling problem. Moreover, fuzzy decision making process is employed to extract one of the Pareto-optimal solutions as the best compromise non-dominated solution. The wind power and demand forecast errors are considered in this approach and the reserve can be furnished by the main grid as well as distributed generators and responsive loads. The consumers participate in both energy and reserve markets using various demand response programs. In order to facilitate small and medium loads participation in demand response programs, a Demand Response Provider (DRP) aggregates offers for load reduction. In order to solve the proposed optimization model, the Benders decomposition technique is used to convert the large scale mixed integer non-linear problem into mixed-integer linear programming and non-linear programming problems. The effectiveness of the proposed scheduling approach is verified on a 41-bus distribution test system over a 24-h period

  6. The NOAA Real-Time Solar-Wind (RTSW) System using ACE Data

    Science.gov (United States)

    Zwickl, R. D.; Doggett, K. A.; Sahm, S.; Barrett, W. P.; Grubb, R. N.; Detman, T. R.; Raben, V. J.; Smith, C. W.; Riley, P.; Gold, R. E.; Mewaldt, R. A.; Maruyama, T.

    1998-07-01

    The Advanced Composition Explorer (ACE) RTSW system is continuously monitoring the solar wind and produces warnings of impending major geomagnetic activity, up to one hour in advance. Warnings and alerts issued by NOAA allow those with systems sensitive to such activity to take preventative action. The RTSW system gathers solar wind and energetic particle data at high time resolution from four ACE instruments (MAG, SWEPAM, EPAM, and SIS), packs the data into a low-rate bit stream, and broadcasts the data continuously. NASA sends real-time data to NOAA each day when downloading science data. With a combination of dedicated ground stations (CRL in Japan and RAL in Great Britain), and time on existing ground tracking networks (NASA's DSN and the USAF's AFSCN), the RTSW system can receive data 24 hours per day throughout the year. The raw data are immediately sent from the ground station to the Space Environment Center in Boulder, Colorado, processed, and then delivered to its Space Weather Operations center where they are used in daily operations; the data are also delivered to the CRL Regional Warning Center at Hiraiso, Japan, to the USAF 55th Space Weather Squadron, and placed on the World Wide Web. The data are downloaded, processed and dispersed within 5 min from the time they leave ACE. The RTSW system also uses the low-energy energetic particles to warn of approaching interplanetary shocks, and to help monitor the flux of high-energy particles that can produce radiation damage in satellite systems.

  7. Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC®

    Directory of Open Access Journals (Sweden)

    Bernoud-Hubac Nathalie

    2017-03-01

    Full Text Available Docosahexaenoic acid (DHA; 22:6 ω-3 is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. Findings suggested that DHA is better incorporated into the brain when esterified at the sn-2 position of a lysophosphatidylcholine (LysoPC-DHA. AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® is a specific and preferred carrier of DHA to the brain. When AceDoPC® was injected to rats that were subjected to an ischemic stroke, it prevents the extension of brain lesions. Regarding the essential role of DHA for cerebral functions, targeting the brain with specific carriers of DHA might provide novel therapeutic approaches to neurodegenerative diseases.

  8. Evaluation of ACE inhibitors lipophilicity using in silico and chromatographically obtained hydrophobicity parameters

    Directory of Open Access Journals (Sweden)

    Odović Jadranka V.

    2013-01-01

    Full Text Available The aim of this study was to compare different calculation methods to determine lipophilicity, expressed as logP value, of seven ACE inhibitors (enalapril, quinapril, fosinopril, lisinopril, cilazapril, ramipril, and benazapril with significantly different structure. Experimentally determined n-octanol/water partition coefficients, logPO/W values, were obtained from relevant literature. The correlations between all collected logP values were studied and the best agreements between calculated logP and experimentally determined logPO/W values, were observed for KOWWINlogP or MilogP values (r = 0.999 or r = 0.974, respectively. The correlations between all collected logP values and chromatographically (reversed-phase thin-layer chromatography obtained hydrophobicity parameters, RM0 and C0, were established. The good correlations (r > 0.90 were obtained in the majority of relationships. The KOWWINlogP was established as the most suitable hydrophobicity parameter of investigated group of ACE inhibitors with r = 0.981 for correlation with RM0 and r = 0.977 for correlation with C0 parameters (water-methanol mobile phase. Using multiple linear regressions, it was established that application of two selected logP, calculated by different mathematical approaches, led to very good correlation due to the benefits of both calculation methods. The good relationships indicate that the computed logP, with careful selection of method calculation, can be useful in ACE inhibitors lipophilicity evaluation, as high-throughput screening technique.

  9. [Diagnostic process and management of schizophrenia in Spain: the ACEE project].

    Science.gov (United States)

    Baca Baldomero, E; Leal Cercós, C; Varela, C; Riesgo, Y; Roca, M

    2006-01-01

    Although schizophrenia has a great impact on the health care, social and family levels, there is little epidemiological information on patients with schizophrenia, its diagnosis and treatment in Spain. The ACEE (Abordaje Clínico de la Esquizofrenia en España; Clinical Approach to Schizophrenia in Spain) study was designed with the primary objective of defining the management of schizophrenia in Spain from the perspective of current clinical practice. ACEE is a descriptive cross-sectional multicenter observational study with data collected in the setting of current clinical practice by means of a specifically designed questionnaire. A total of 1,937 patients have been studied (83% pertaining to the public sector and 17% to private one). Most subjects had paranoid schizophrenia in the stabilization phase, and did not work because of their illness. Most (96%) were receiving antipsychotic treatment and 55% also received some non-drug treatment. Negative symptoms were more frequent than positive symptoms (88% versus 63%). Significant differences were observed for type of patients and diagnostic procedures involved between the public and private health care sectors. The ACEE study shows that schizophrenic patients attending Spanish psychiatric centers are mainly single, non-working males who are living in their family setting. Treatment basically consists of antipsychotics combined with other drugs, and few complementary examinations are performed.

  10. Comparison of the diabetes guidelines from the ADA/EASD and the AACE/ACE.

    Science.gov (United States)

    Cornell, Susan

    To compare recent diabetes guideline updates from the American Diabetes Association-European Association for the Study of Diabetes (ADA/EASD) and the American Association of Clinical Endocrinologists-American College of Endocrinology (AACE/ACE). The ADA/EASD guideline continues to advocate a stepwise approach to glycemic control that initiates with metformin and intensifies treatment incrementally to dual and triple therapy at 3-month intervals until the patient is at their individualized goal. The AACE/ACE guideline provides a broader choice of first-line medications, with a suggested hierarchy of use, and it encourages initial dual and triple therapy if the glycated hemoglobin (A1C) level is high enough at diagnosis (7.5%-9.0% and >9.0%, respectively). Target A1C levels are higher in the ADA/EASD guideline (≤7.0%) compared with the AACE/ACE guideline (≤6.5%), although both statements indicate that targets should be adjusted to specific clinical scenarios based on safety. Both guidelines now include the new sodium-glucose cotransporter-2 inhibitors among their choices of acceptable glucose-lowering medications and endorse the overall cardiovascular and pancreatic safety of incretin therapies, and the safety of pioglitazone vis-a-vis bladder cancer. In practice, the ADA/EASD guidelines tend to be more user-friendly for general practitioners because of the simple stepwise intensification regimen, whereas the AACE/ACE guidelines are more commonly followed by specialists (endocrinologists) because of the more aggressive A1C targets. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  11. A risk-economic approach to nuclear power generation. Beyond the myth of absolute safety and unthinkable events

    International Nuclear Information System (INIS)

    Sakai, Yasuhiro

    2012-01-01

    This paper deals with a risk-economic approach to nuclear power generation, a very timely yet rather neglected area in the economics profession. The economic and psychological consequences of Japan's recent catastrophe have been so grave and wide-spread, thus calling for careful reexamination of the economics of risk and uncertainty. It is Daniel Bernoulli, a mathematical genius of the 18 th century, who first introduced the expected utility theory into decision making under risk. Although a great deal of applications has been done in many areas since then, it appears that the most recent nuclear meltdown of Japan is casting serious doubt upon the general validity of existing risk theories. It is high time for us to establish a new comprehensive approach by taking account of psychological, sociological, cultural, and historical factors. (author)

  12. Economic Empowerment of Communities through Tourism: A Pro-Poor Tourism Value Chain Approach

    Directory of Open Access Journals (Sweden)

    Rayviscic Mutinda NDIVO

    2015-12-01

    Full Text Available A number of constraints continue to limit participation of the local people to tourism and travel activities in the less and developing countries. Addressing such constraints has over time formed the focus of development paradigms in these countries. This paper uses analytical literature review for identifying the appropriate strategies promoting host community participation and the benefits of tourism development by giving particular emphasis on less and developing countries. Specifically, the paper critiques pro-poor tourism (PPT and tourism value chain (TVC approaches, in view of their feasibility for ensuring that tourism benefits the poor within the host community. By demonstrating their inherent limitations and strengths as models for empowering poor communities, the paper proposes an integrated model -Pro-Poor Tourism Value Chain- that integrates the strengths of both PPT and TVC approaches into a single framework. This framework would find important policy and practical application in enhancing economic participation of host communities in tourism. To realise this goal, the paper recommends mapping of appropriate TVC nodes, identification of intervention strategies for increasing benefits arising to those already participating in the TVC, and developing capacity of those not involved through pro-poor affirmative initiatives.

  13. A bio-economic application to the Cape Rock Lobster resource using a delay difference modelling approach

    Directory of Open Access Journals (Sweden)

    E Roos

    2004-06-01

    Full Text Available In many species, like the Cape Rock Lobster (Jasus lalandii, the life cycles of males and females differ. This may motivate the use of two-sex models in a stock-assessment analysis. It is also true for this resource, that juveniles do not reach sexual maturity immediately. Therefore a delay-difference model is appropriate. In this study we follow a bio-economic approach and use a two-sex delay-difference model to determine a maximum economic yield strategy. Thus we determine an economic optimum steady state solution at which to harvest this resource subject to the biological constraints of the species.

  14. OPTICAL CROSS-CORRELATION FILTERS: AN ECONOMICAL APPROACH FOR IDENTIFYING SNe Ia AND ESTIMATING THEIR REDSHIFTS

    International Nuclear Information System (INIS)

    Scolnic, Daniel M.; Riess, Adam G.; Huber, Mark E.; Rest, Armin; Stubbs, Christoper W.; Tonry, John L.

    2009-01-01

    Large photometric surveys of transient phenomena, such as Panoramic Survey Telescope and Rapid Response System and Large Synoptic Survey Telescope, will locate thousands to millions of Type Ia supernova (SN Ia) candidates per year, a rate prohibitive for acquiring spectroscopy to determine each candidate's type and redshift. In response, we have developed an economical approach to identifying SNe Ia and their redshifts using an uncommon type of optical filter which has multiple, discontinuous passbands on a single substrate. Observation of a supernova through a specially designed pair of these 'cross-correlation filters' measures the approximate amplitude and phase of the cross-correlation between the spectrum and a SN Ia template, a quantity typically used to determine the redshift and type of a high-redshift SN Ia. Simulating the use of these filters, we obtain a sample of SNe Ia which is ∼98% pure with individual redshifts measured to σ z = 0.01 precision. The advantages of this approach over standard broadband photometric methods are that it is insensitive to reddening, independent of the color data used for subsequent distance determinations which reduce selection or interpretation bias, and because it makes use of the spectral features its reliability is greater. A great advantage over long-slit spectroscopy comes from increased throughput, enhanced multiplexing, and reduced setup time resulting in a net gain in speed of up to ∼30 times. This approach is also insensitive to host galaxy contamination. Prototype filters were built and successfully used on Magellan with LDSS-3 to characterize three SuperNova Legacy Survey candidates. We discuss how these filters can provide critical information for the upcoming photometric supernova surveys.

  15. Regulation of the aceI multidrug efflux pump gene in Acinetobacter baumannii.

    Science.gov (United States)

    Liu, Qi; Hassan, Karl A; Ashwood, Heather E; Gamage, Hasinika K A H; Li, Liping; Mabbutt, Bridget C; Paulsen, Ian T

    2018-06-01

    To investigate the function of AceR, a putative transcriptional regulator of the chlorhexidine efflux pump gene aceI in Acinetobacter baumannii. Chlorhexidine susceptibility and chlorhexidine induction of aceI gene expression were determined by MIC and quantitative real-time PCR, respectively, in A. baumannii WT and ΔaceR mutant strains. Recombinant AceR was prepared as both a full-length protein and as a truncated protein, AceR (86-299), i.e. AceRt, which has the DNA-binding domain deleted. The binding interaction of the purified AceR protein and its putative operator region was investigated by electrophoretic mobility shift assays and DNase I footprinting assays. The binding of AceRt with its putative ligand chlorhexidine was examined using surface plasmon resonance and tryptophan fluorescence quenching assays. MIC determination assays indicated that the ΔaceI and ΔaceR mutant strains both showed lower resistance to chlorhexidine than the parental strain. Chlorhexidine-induced expression of aceI was abolished in a ΔaceR background. Electrophoretic mobility shift assays and DNase I footprinting assays demonstrated chlorhexidine-stimulated binding of AceR with two sites upstream of the putative aceI promoter. Surface plasmon resonance and tryptophan fluorescence quenching assays suggested that the purified ligand-binding domain of the AceR protein was able to bind with chlorhexidine with high affinity. This study provides strong evidence that AceR is an activator of aceI gene expression when challenged with chlorhexidine. This study is the first characterization, to our knowledge, of a regulator controlling expression of a PACE family multidrug efflux pump.

  16. Integrated Approach for Improving Small Scale Market Oriented Dairy Systems in Pakistan: Economic Impact of Interventions

    Directory of Open Access Journals (Sweden)

    A. Ghaffar

    2010-02-01

    Full Text Available The International Atomic Energy Agency (IAEA launched a Coordinated Research Program in 10 developing countries including Pakistan involving small scale market oriented dairy farmers to identify and prioritize the constraints and opportunities in the selected dairy farms, develop intervention strategies and assess the economic impact of the intervention. The interventions in animal health (control of mastitis at sub-clinical stage and reduction in calf mortality, nutrition (balanced feed reproduction (mineral supplementation, and general management (training of farmers were identified and implemented in a participatory approach at the selected dairy farms. The calf mortality was reduced from 35 to 13 percent up to the age of 3 months. Use of Alfa Deval post milking teat dips reduced the incidence of sub-clinical mastitis from 34 to 5% showing economical benefits of the interventions. Partial budget technique was used to analyze its impact in the registered herds. The farmers recorded monthly quantities of different feed ingredients and seasonal green fodder offered to the animals. From this data set total metabolizeable energy requirements and availability from feed were computed which revealed that animals were deficient in metabolizeable energy in all locations. This was also confirmed by seasonal variation in body condition scoring. At some selected farms the mineral mixture supplement was introduced which exhibited increased milk yield by 5 % in addition to shorten service period by 30 days. Three sessions of training were arranged to train the farmers to care new born calves, daily farm management and detect the animals in heat efficiently to enhance the over all income of the farmers. The overall income of the farm was increased by 40%.

  17. Bio-economic modeling of water quality improvements using a dynamic applied general equilibrium approach

    NARCIS (Netherlands)

    Dellink, R.; Brouwer, R.; Linderhof, V.G.M.; Stone, K.

    2011-01-01

    An integrated bio-economic model is developed to assess the impacts of pollution reduction policies on water quality and the economy. Emission levels of economic activities to water are determined based on existing environmental accounts. These emission levels are built into a dynamic economic model

  18. Ecological-economical approach to assessment of environment state at the Semipalatinsk test site

    International Nuclear Information System (INIS)

    Chugunova, N.S.; Balykbaeva, S.Y.

    2002-01-01

    The paper presents methods used for ecological-economical assessment of the environment condition at the former Semipalatinsk Test Site. It also presents methodology of calculating ecological and economical parameters for different options. Besides, the paper provides data describing assessment of ecological and economical damage caused by defense establishment activities at the Semipalatinsk Test Site. (author)

  19. Multilevel approaches and the firm-agglomeration ambiguity in economic growth studies

    NARCIS (Netherlands)

    van Oort, F.G.|info:eu-repo/dai/nl/107712741; Burger, M.J.|info:eu-repo/dai/nl/371741092; Knoben, J.; Raspe, O.

    2012-01-01

    Empirical studies in spatial economics have shown that agglomeration economies may be a source of the uneven distribution of economic activities and economic growth across cities and regions. Both localization and urbanization economies are hypothesized to foster agglomeration and growth, but recent

  20. Multilevel approaches and the firm-agglomeration ambiguity in economic growth studies

    NARCIS (Netherlands)

    Oort, F.G. van; Burger, M.J.; Knoben, J.; Raspe, O.

    2012-01-01

    Empirical studies in spatial economics have shown that agglomeration economies may be a source of the uneven distribution of economic activities and economic growth across cities and regions. Both localization and urbanization economies are hypothesized to foster agglomeration and growth, but

  1. Optimization of Goat Milk with ACE Inhibitory Peptides Fermented by Lactobacillus bulgaricus LB6 Using Response Surface Methodology.

    Science.gov (United States)

    Shu, Guowei; Shi, Xiaoyu; Chen, He; Ji, Zhe; Meng, Jiangpeng

    2017-11-21

    In the present study, the incubation conditions of goat milk fermented by Lactobacillus bulgaricus LB6 were optimized to increase the angiotensin converting enzyme (ACE, EC 3.4.15.1) inhibitory activity by Box-Behnken design of response surface methodology. Incubation temperature, whey powder, and calcium lactate had significant effects on ACE inhibition rate and viable counts of LB6 during incubation. The results showed that optimal conditions of fermentation were found to be 37.05 °C, 0.8% ( w / w ) whey powder and 0.50% ( w / w ) calcium lactate. ACE inhibition rate increased significantly from 71.04 ± 0.37% to 83.31 ± 0.45% and the viable counts of Lactobacillus bulgaricus LB6 reached to 8.03 × 10⁷ cfu·mL -1 under the optimal conditions, which approached the predicted values 83.25% and 8.04 × 10⁷ cfu·mL -1 . The optimal fermentation conditions can be a good reference for preparing ACE inhibitory peptides from goat milk.

  2. Optimization of Goat Milk with ACE Inhibitory Peptides Fermented by Lactobacillus bulgaricus LB6 Using Response Surface Methodology

    Directory of Open Access Journals (Sweden)

    Guowei Shu

    2017-11-01

    Full Text Available In the present study, the incubation conditions of goat milk fermented by Lactobacillus bulgaricus LB6 were optimized to increase the angiotensin converting enzyme (ACE, EC 3.4.15.1 inhibitory activity by Box–Behnken design of response surface methodology. Incubation temperature, whey powder, and calcium lactate had significant effects on ACE inhibition rate and viable counts of LB6 during incubation. The results showed that optimal conditions of fermentation were found to be 37.05 °C, 0.8% (w/w whey powder and 0.50% (w/w calcium lactate. ACE inhibition rate increased significantly from 71.04 ± 0.37% to 83.31 ± 0.45% and the viable counts of Lactobacillus bulgaricus LB6 reached to 8.03 × 107 cfu·mL−1 under the optimal conditions, which approached the predicted values 83.25% and 8.04 × 107 cfu·mL−1. The optimal fermentation conditions can be a good reference for preparing ACE inhibitory peptides from goat milk.

  3. Final Report for Harvesting a New Wind Crop: Innovative Economic Approaches for Rural America

    Energy Technology Data Exchange (ETDEWEB)

    Susan Innis; Randy Udall; Project Officer - Keith Bennett

    2005-09-30

    Final Report for ''Harvesting a New Wind Crop: Innovative Economic Approaches for Rural America'': This project, ''Harvesting a New Wind Crop'', helped stimulate wind development by rural electric cooperatives and municipal utilities in Colorado. To date most of the wind power development in the United States has been driven by large investor-owned utilities serving major metropolitan areas. To meet the 5% by 2020 goal of the Wind Powering America program the 2,000 municipal and 900 rural electric cooperatives in the country must get involved in wind power development. Public power typically serves rural and suburban areas and can play a role in revitalizing communities by tapping into the economic development potential of wind power. One barrier to the involvement of public power in wind development has been the perception that wind power is more expensive than other generation sources. This project focused on two ways to reduce the costs of wind power to make it more attractive to public power entities. The first way was to develop a revenue stream from the sale of green tags. By selling green tags to entities that voluntarily support wind power, rural coops and munis can effectively reduce their cost of wind power. Western Resource Advocates (WRA) and the Community Office for Resource Efficiency (CORE) worked with Lamar Light and Power and Arkansas River Power Authority to develop a strategy to use green tags to help finance their wind project. These utilities are now selling their green tags to Community Energy, Inc., an independent for-profit marketer who in turn sells the tags to consumers around Colorado. The Lamar tags allow the University of Colorado-Boulder, the City of Boulder, NREL and other businesses to support wind power development and make the claim that they are ''wind-powered''. This urban-rural partnership is an important development for the state of Colorado's rural communities

  4. Approaches for Assessing the Economic Competitiveness of Small and Medium Sized Reactors

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-12-15

    periods, unit timing (spread of investments over time); and, possibly, greater involvement of local industry and local labour. The effectiveness of all of these approaches to SMR design and deployment depends on the application and on market variables, such as interest rates, and needs to be assessed and demonstrated for specific cases. Upon the advice and with the support of IAEA Member States, the IAEA provides a forum for the exchange of information by experts and policy makers from industrialized and developing countries on the technical, economic, environmental and social aspects of SMR development and implementation in the twenty-first century, and makes this information available to all interested Member States by producing status reports and other publications dedicated to advances in SMR design and technology development. This report was prepared to assist existing and potential stakeholders in Member States in understanding the economic competitiveness of SMR technologies compared to other energy sources and large reactors (LRs); to provide information on available approaches and frameworks to assess the economic competitiveness of advanced SMRs and LRs under specific conditions of their application; and to share knowledge on positive experiences of several Member States that are introducing SMRs into their energy mix. The report is intended for a variety of stakeholders including: design organizations involved in SMR development programmes; investors and potential users of innovative SMRs; and officers in the ministries or atomic energy commissions in Member States responsible for implementing nuclear technology development programmes or evaluating nuclear power deployment options in the near, medium and longer term. The main sections of this report highlight the experience with and future plans for SMRs in several Member States, and present the available methodological options to assist design organizations and guide potential users on the economic performance

  5. Optimal approaches to the health economics of palliative care: report of an international think tank.

    Science.gov (United States)

    Gomes, Barbara; Harding, Richard; Foley, Kathleen M; Higginson, Irene J

    2009-07-01

    More people will need palliative care in aging societies with stretched health budgets and less ability to provide informal care. The future will bring new and tougher challenges to sustain, optimize, and expand the 8000 dedicated palliative care services that currently exist in the world. The full breakdown of the costs of palliative care is yet to be unveiled, and this has left huge unresolved questions for funding, costing, evaluating, and modeling palliative care. At an international meeting in London in November 2007, a group of 40 researchers, health economists, policy makers, and advocates exchanged their experiences, concerns, and recommendations in five main areas: shared definitions, strengths and weaknesses of different payment systems, international and country-specific research challenges, appropriate economic evaluation methods, and the varied perspectives to the costs of palliative care. This article reports the discussions that took place and the views of this international group of experts on the best research approaches to capture, analyze, and interpret data on both costs and outcomes for families and patients toward the end of life.

  6. A modified differential evolution approach for dynamic economic dispatch with valve-point effects

    International Nuclear Information System (INIS)

    Yuan Xiaohui; Wang Liang; Yuan Yanbin; Zhang Yongchuan; Cao Bo; Yang Bo

    2008-01-01

    Dynamic economic dispatch (DED) plays an important role in power system operation, which is a complicated non-linear constrained optimization problem. It has nonsmooth and nonconvex characteristic when generation unit valve-point effects are taken into account. This paper proposes a modified differential evolution approach (MDE) to solve DED problem with valve-point effects. In the proposed MDE method, feasibility-based selection comparison techniques and heuristic search rules are devised to handle constraints effectively. In contrast to the penalty function method, the constraints-handling method does not require penalty factors or any extra parameters and can guide the population to the feasible region quickly. Especially, it can be satisfied equality constraints of DED problem precisely. Moreover, the effects of two crucial parameters on the performance of the MDE for DED problem are studied as well. The feasibility and effectiveness of the proposed method is demonstrated for application example and the test results are compared with those of other methods reported in literature. It is shown that the proposed method is capable of yielding higher quality solutions

  7. A Three-Stage Optimal Approach for Power System Economic Dispatch Considering Microgrids

    Directory of Open Access Journals (Sweden)

    Wei-Tzer Huang

    2016-11-01

    Full Text Available The inclusion of microgrids (MGs in power systems, especially distribution-substation-level MGs, significantly affects power systems because of the large volumes of import and export power flows. Consequently, power dispatch has become complicated, and finding an optimal solution is difficult. In this study, a three-stage optimal power dispatch model is proposed to solve such dispatch problems. In the proposed model, the entire power system is divided into two parts, namely, the main power grid and MGs. The optimal power dispatch problem is resolved on the basis of multi-area concepts. In stage I, the main power system economic dispatch (ED problem is solved by sensitive factors. In stage II, the optimal power dispatches of the local MGs are addressed via an improved direct search method. In stage III, the incremental linear models for the entire power system can be established on the basis of the solutions of the previous two stages and can be subjected to linear programming to determine the optimal reschedules from the original dispatch solutions. The proposed method is coded using Matlab and tested by utilizing an IEEE 14-bus test system to verify its feasibility and accuracy. Results demonstrated that the proposed approach can be used for the ED of power systems with MGs as virtual power plants.

  8. The efficiency frontier approach to economic evaluation of health-care interventions.

    Science.gov (United States)

    Caro, J Jaime; Nord, Erik; Siebert, Uwe; McGuire, Alistair; McGregor, Maurice; Henry, David; de Pouvourville, Gérard; Atella, Vincenzo; Kolominsky-Rabas, Peter

    2010-10-01

    IQWiG commissioned an international panel of experts to develop methods for the assessment of the relation of benefits to costs in the German statutory health-care system. The panel recommended that IQWiG inform German decision makers of the net costs and value of additional benefits of an intervention in the context of relevant other interventions in that indication. To facilitate guidance regarding maximum reimbursement, this information is presented in an efficiency plot with costs on the horizontal axis and value of benefits on the vertical. The efficiency frontier links the interventions that are not dominated and provides guidance. A technology that places on the frontier or to the left is reasonably efficient, while one falling to the right requires further justification for reimbursement at that price. This information does not automatically give the maximum reimbursement, as other considerations may be relevant. Given that the estimates are for a specific indication, they do not address priority setting across the health-care system. This approach informs decision makers about efficiency of interventions, conforms to the mandate and is consistent with basic economic principles. Empirical testing of its feasibility and usefulness is required.

  9. TiO2 nanoparticles prepared without harmful organics: A biosafe and economical approach

    KAUST Repository

    Shah, M.A.

    2011-06-01

    Growth of titanium oxide (TiO2) nanoparticles of varying size, ranging from 20-60 nms through a versatile and an economic route, is being reported. The approach is based on a simple reaction of titanium powder and De-Ionized (DI) water at ∼180 °C, without use of any harmful additives. Field Emission Scanning Electron Microscopy (FESEM) reveals the well defined morphology of nanoparticles, whereas X-ray Diffraction (XRD) studies reveal that the, as prepared, nanoparticles are in a mixed phase, with a dominance of a stable rutile phase. Since only water, which is regarded as a benign solvent, is used during the preparation of nanoparticles, we believe that the products so produced are biocompatible and bio-safe and can be readily used for medical applications. The biocompatibility tests are yet to be carried out and shall be reported in forthcoming publications. © 2011 Sharif University of Technology. Production and hosting by Elsevier B.V. All rights reserved.

  10. The Economic Determinants of Bioenergy Trade Intensity in the EU-28: A Co-Integration Approach

    Directory of Open Access Journals (Sweden)

    Mohd Alsaleh

    2018-02-01

    Full Text Available This paper examines the dynamic effect of the economic determinants on bilateral trade intensity of the European Union (EU region’s bioenergy industry outputs. The authors adopt the panel co-integration model approach to estimate annual trade intensity data of the EU-28 countries’ bioenergy industry outputs from 1990 to 2013. This study investigated the long-term influence of the rate of real exchange, gross domestic product (GDP, and export price on the trade intensity of bioenergy industry applying fully modified oriented least square (FMOLS, dummy oriented least square (DOLS, and pooled mean group (PMG models. In the current study, the findings boost the empirical validity of the panel co-integration model through FMOLS, indicating that depreciation has improved the trade intensity. This study has further investigated, through the causality test, a distinct set of countries. FMOLS estimation does find proof of the long run improvement of trade intensity. Thus, the result shows that the gross domestic product (GDP and the real exchange rate have a positive and noteworthy influence on the EU-28 region trade intensity of the bioenergy industry. Moreover, the export price affects negatively and significantly the trade intensity of the bioenergy industry in the EU-28 countries.

  11. Hydronephrosis alters cardiac ACE2 and Mas receptor expression in mice.

    Science.gov (United States)

    Zhang, Yanling; Ma, Lulu; Wu, Junyan; Chen, Tingting

    2015-06-01

    Hydronephrosis is characterized by substantial loss of tubules and affects renin secretion in the kidney. However, whether alterations of angiotensin-converting enzyme (ACE), ACE2 and Mas receptor in the heart are observed in hydronephrosis is unknown. Thus, we assessed these components in hydronephrotic mice treated with AT1 receptor blockade and ACE inhibitor. Hydronephrosis was induced by left ureteral ligation in Balb/C mice except sham-operated animals. The levels of cardiac ACE, ACE2 and Mas receptor were measured after treatment of losartan or enalapril. Hydronephrosis led to an increase of ACE level and a decrease of ACE2 and Mas receptor in the heart. Losartan decreased cardiac ACE level, but ACE2 and Mas receptor levels significantly increased in hydronephrotic mice (p Hydronephrosis increased cardiac ACE and suppressed ACE2 and Mas receptor levels. AT1 blockade caused sustained activation of cardiac ACE2 and Mas receptor, but ACE inhibitor had the limitation of such activation of Mas receptor in hydronephrotic animals. © The Author(s) 2015.

  12. Advanced Colloids Experiment (ACE) Science Overview

    Science.gov (United States)

    Meyer, William V.; Sicker, Ronald J.; Chiaramonte, Francis P.; Luna, Unique J.; Chaiken, Paul M.; Hollingsworth, Andrew; Secanna, Stefano; Weitz, David; Lu, Peter; Yodh, Arjun; hide

    2013-01-01

    accessible with the availability of the Light Microscopy Module (LMM) on ISS. To meet these goals, the ACE experiment is being built-up in stages, with the availability of confocal microscopy being the ultimate objective. Supported by NASAs Physical Sciences Research Program, ESAESTEC, and the authors respective governments.

  13. [Job satisfaction among the professionals of AceS Baixo Vouga II].

    Science.gov (United States)

    Santana, Silvina; Cerdeira, José

    2011-12-01

    Job satisfaction is a measure of quality of life at work and is related to emotional states. The interest for this theme is increasing and, in the last years, many studies have attempted to demonstrate its relation with professional performance. Primary care professionals are in the first line of the Serviço Nacional de Saúde (SNS). Therefore, it is necessary that they feel satisfaction with their jobs, in order to perform the tasks with the quality required. Several factors seem to have impact in the satisfaction of these professionals, such as payment, promotion, recognition from supervisors and peers, physical conditions at work and available resources, opportunities for personal development, among others. Insatisfaction may lead to absentism and in the limit to job quit. The main objective of this work is to study job satisfaction among the professionals working at the health centers of ACeS Baixo Vouga II, namely, the relationship between job characteristics and job satisfaction and between job characteristics and considering job quit as a serious option. All the professionals working in the four health centers were inquired. Results show that job characteristics are defined by six dimensions: leadership and supervision, task characteristics and autonomy, payment, personal and professional development and promotion, peers and relations inside the organization and work environment. Globally, payment and opportunities for personal and professional development and promotion are perceived at low level by all the professional groups. Results also show that there are differences by gender and professional groups regarding job satisfaction and the will to quit job. Considering the specificity of the tasks performed by these professionals, measures should be taken in order to improve job satisfaction in the Portuguese health centers.

  14. The ACES mission: scientific objectives and present status

    Science.gov (United States)

    Cacciapuoti, L.; Dimarcq, N.; Salomon, C.

    2017-11-01

    "Atomic Clock Ensemble in Space" (ACES) is a mission in fundamental physics that will operate a new generation of atomic clocks in the microgravity environment of the International Space Station (ISS). The ACES clock signal will combine the medium term frequency stability of a space hydrogen maser (SHM) and the long term stability and accuracy of a frequency standard based on cold cesium atoms (PHARAO). Fractional frequency stability and accuracy of few parts in 1016 will be achieved. The on-board time base distributed on Earth via a microwave link (MWL) will be used to test fundamental laws of physics (Einstein's theories of Special and General Relativity, Standard Model Extension, string theories…) and to develop applications in time and frequency metrology, universal time scales, global positioning and navigation, geodesy and gravimetry. After a general overview on the mission concept and its scientific objectives, the present status of ACES instruments and sub-systems will be discussed.

  15. The ACE gene and human performance: 12 years on.

    Science.gov (United States)

    Puthucheary, Zudin; Skipworth, James R A; Rawal, Jai; Loosemore, Mike; Van Someren, Ken; Montgomery, Hugh E

    2011-06-01

    Some 12 years ago, a polymorphism of the angiotensin I-converting enzyme (ACE) gene became the first genetic element shown to impact substantially on human physical performance. The renin-angiotensin system (RAS) exists not just as an endocrine regulator, but also within local tissue and cells, where it serves a variety of functions. Functional genetic polymorphic variants have been identified for most components of RAS, of which the best known and studied is a polymorphism of the ACE gene. The ACE insertion/deletion (I/D) polymorphism has been associated with improvements in performance and exercise duration in a variety of populations. The I allele has been consistently demonstrated to be associated with endurance-orientated events, notably, in triathlons. Meanwhile, the D allele is associated with strength- and power-orientated performance, and has been found in significant excess among elite swimmers. Exceptions to these associations do exist, and are discussed. In theory, associations with ACE genotype may be due to functional variants in nearby loci, and/or related genetic polymorphism such as the angiotensin receptor, growth hormone and bradykinin genes. Studies of growth hormone gene variants have not shown significant associations with performance in studies involving both triathletes and military recruits. The angiotensin type-1 receptor has two functional polymorphisms that have not been shown to be associated with performance, although studies of hypoxic ascent have yielded conflicting results. ACE genotype influences bradykinin levels, and a common gene variant in the bradykinin 2 receptor exists. The high kinin activity haplotye has been associated with increased endurance performance at an Olympic level, and similar results of metabolic efficiency have been demonstrated in triathletes. Whilst the ACE genotype is associated with overall performance ability, at a single organ level, the ACE genotype and related polymorphism have significant

  16. Efficacy of lycopene on modulation of renal antioxidant enzymes, ACE and ACE gene expression in hyperlipidaemic rats.

    Science.gov (United States)

    Khan, Nazish Iqbal; Noori, Shafaq; Mahboob, Tabassum

    2016-07-01

    We aimed to evaluate the efficacy of lycopene on renal tissue antioxidant enzymes and angiotensin converting enzyme (ACE) gene expression and serum activity in diet-induced hyperlipidaemia. Thirty-two female Wistar albino rats (200-250 g weight), 5-6 months of age, were randomly selected and divided into four groups. Group I received normal diet; group II received 24 g high fat diet/100 g of daily diet; group III received 24 g high fat diet/100 g daily diet and 200 ml of lycopene extract (twice a week) for 8 weeks; and group IV received 200 ml oral lycopene extract twice a week for 8 weeks. A marked increase was observed in plasma urea and creatinine levels, serum C-reactive protein, kidney weight, tissue renal malonyldialdehyde level, ACE gene expression and serum level, while a decrease catalase level among hyperlipidaemic rats was observed. Histologically, interstitial inflammation and proliferation was seen. Lycopene supplementation significantly decreased plasma urea and creatinine, serum ACE, renal tissue malonyldialdehyde level and C-reactive protein level, while it increased tissue antioxidant enzymes level and total protein. Tissue inflammation and proliferation was improved. This finding suggests that supplementation of lycopene is effective for renal antioxidant enzymes, ACE gene expression and ACE serum level in hyperlipidaemic rats. © The Author(s) 2016.

  17. Socio-economic scenario development for the assessment of climate change impacts on agricultural land use: a pairwise comparison approach

    DEFF Research Database (Denmark)

    Abildtrup, Jens; Audsley, E.; Fekete-Farkas, M.

    2006-01-01

    Assessment of the vulnerability of agriculture to climate change is strongly dependent on concurrent changes in socio-economic development pathways. This paper presents an integrated approach to the construction of socio-economic scenarios required for the analysis of climate change impacts...... on European agricultural land use. The scenarios are interpreted from the storylines described in the intergovernmental panel on climate change (IPCC) special report on emission scenarios (SRES), which ensures internal consistency between the evolution of socio-economics and climate change. A stepwise...... downscaling procedure based on expert-judgement and pairwise comparison is presented to obtain quantitative socio-economic parameters, e.g. prices and productivity estimates that are input to the ACCELERATES integrated land use model. In the first step, the global driving forces are identified and quantified...

  18. ANALYSIS OF RESOURCE AND NON-RESOURCE FACTORS’ INFLUENCE ON ECONOMIC GROWTH OF TOMSK REGION USING COGNITIVE APPROACH

    Directory of Open Access Journals (Sweden)

    Belan A. K.

    2015-03-01

    Full Text Available This article introduces the key problems of social-economic development of Tomsk region and factors that influence economic growth in highly resource-dependent region. Authors prove the advisability of using cognitive approach for investigation and forecasting of social-economic system development in conditions of uncertainty. Also results of simulation are given medium-term forecast. They are interpreted by means of fuzzy cognitive map. Obtained results, on the one hand, confirm the theoretical considerations about the need of convergence between various factors in the regional development strategy. On the other hand, it’s revealed the need to build a normative model, showing what the regional economy should be. This will allow to conceive more clearly the direction of movement from the modern position to desired one and to determine required contours of the economic policy.

  19. Taxes and Economic Growth in Developing Countries : A Dynamic Panel Approach

    OpenAIRE

    NANTOB, N'Yilimon

    2014-01-01

    This paper looks at the effects of taxes increase on economic growth of 47 developing countries. In developing countries, there is no magic tax strategy to encourage economic growth. Some countries with high tax burdens have high growth rates and some countries with low tax burdens have low growth rates. Despite much theoretical and empirical inquiry as well as political and policy controversy, no simple answer exists concerning the relationship of taxes on economic growth in developing count...

  20. Online solving of economic dispatch problem using neural network approach and comparing it with classical method

    International Nuclear Information System (INIS)

    Mohammadi, A.; Varahram, M.H.

    2007-01-01

    In this study, two methods for solving economic dispatch problems, namely Hopfield neural network and lambda iteration method are compared. Three sample of power system with 3, 6 and 20 units have been considered. The time required for CPU, for solving economic dispatch of these two systems has been calculated. It has been Shown that for on-line economic dispatch, Hopfield neural network is more efficient and the time required for Convergence is considerably smaller compared to classical methods. (author)

  1. Carrying capacity an approaching procedure to the economic value of natural patrimony

    International Nuclear Information System (INIS)

    Blandon M, Luis; Ochoa S, German; Ospina N, Efren

    2001-01-01

    This study demonstrates a new alternative method for valorizing the natural heritage of various economically and environmentally important ecosystems. It was conducted in the Piedras Blancas, Antioquia watershed and considered the degree of conservation of the area and its capacity for supporting humans, by means of extractive economic activities. In this way the ecosystem itself provides a natural offer of goods and services and therefore a good approximation of its economic value

  2. NEUMANNIAN ECONOMY IN MULTI-AGENT APPROACH. INVESTIGATION OF STABILITY AND INSTABILITY IN ECONOMIC GROWTH

    Directory of Open Access Journals (Sweden)

    Katalin Martinas

    2004-06-01

    Full Text Available Axiomatic foundation of non-equilibrium microeconomics is outlined. The economic activity is modelled as transformation and transport of commodities (materials owned by the agents. Rate of transformations (production intensity, and the rate of transport (trade are defined by the agents. Economic decision rules are derived from the observed economic behaviour. The non-linear equations are solved numerically for the Neumannian economy. The emergence of the equilibrium market structure appears as an order out of chaos process.

  3. Education for Economic Growth or Human Development? the Capabilities Approach and the World Bank's Basic Education Project in Turkey

    Science.gov (United States)

    McClure, Kevin R.

    2014-01-01

    Turkey's recent development plans suggest that, according to state planners, development is no longer identified with, achieved through or measured by economic growth. These documents evince that Turkey has embraced what is referred to as the capability approach. What remains unclear is whether this embrace is substantive or rhetorical. This paper…

  4. The Project Approach in Organization of Foreign Economic Activity as a Means of Increasing Competitiveness of Industrial Enterprise

    Directory of Open Access Journals (Sweden)

    Lazarenko Vladimir Ye.

    2017-12-01

    Full Text Available The article is aimed at studying the organization of foreign economic activity of industrial enterprise in case of introduction of project approach to its management. New conditions of doing business in terms of aircraft building enterprises, consisting in the transition to production according to international standards, require a modern approach to the solution of the range of issues. In conditions of limited internal financial resources of company and high expenses connected with entering the foreign market, it is extremely important to define the priority directions of foreign economic activity and the most optimal mechanisms of its organization and management. The functioning of the sphere of foreign economic activity of industrial enterprise in case of introduction of project approach to management has been analyzed. The essence, features and the main parameters of project approach as a means of increasing the competitiveness of enterprise have been defined. Priorities of the large-scale enterprise development strategy have been analyzed and suggested by means of carrying out the project method of organization of foreign economic activity.

  5. Economic Policy Instruments and Evaluation Methods in Dutch Water Management: An analysis of their contribution to an integrated approach

    NARCIS (Netherlands)

    S.P. Boot (Sander Paul)

    2007-01-01

    textabstractIn international water policy, a trend can be observed towards more attention for economic approaches in water management. In 1992, at the International Conference on Water and the Environment (ICWE) in Dublin, the Convention on the Protection and Use of Transboundary Water Courses and

  6. Economic and ecological impacts of bioenergy crop production—a modeling approach applied in Southwestern Germany

    Directory of Open Access Journals (Sweden)

    Hans-Georg Schwarz-v. Raumer

    2017-03-01

    Full Text Available This paper considers scenarios of cultivating energy crops in the German Federal State of Baden-Württemberg to identify potentials and limitations of a sustainable bioenergy production. Trade-offs are analyzed among income and production structure in agriculture, bioenergy crop production, greenhouse gas emissions, and the interests of soil, water and species habitat protection. An integrated modelling approach (IMA was implemented coupling ecological and economic models in a model chain. IMA combines the Economic Farm Emission Model (EFEM; key input: parameter sets on farm production activities, the Environmental Policy Integrated Climate model (EPIC; key input: parameter sets on environmental cropping effects and GIS geo-processing models. EFEM is a supply model that maximizes total gross margins on farm level with simultaneous calculation of greenhouse gas emission from agriculture production. Calculations by EPIC result in estimates for soil erosion by water, nitrate leaching, Soil Organic Carbon and greenhouse gas emissions from soil. GIS routines provide land suitability analyses, scenario settings concerning nature conservation and habitat models for target species and help to enable spatial explicit results. The model chain is used to calculate scenarios representing different intensities of energy crop cultivation. To design scenarios which are detailed and in step to practice, comprehensive data research as well as fact and effect analyses were carried out. The scenarios indicate that, not in general but when considering specific farm types, energy crop share extremely increases if not restricted and leads to an increase in income. If so this leads to significant increase in soil erosion by water, nitrate leaching and greenhouse gas emissions. It has to be expected that an extension of nature conservation leads to an intensification of the remaining grassland and of the arable land, which were not part of nature conservation measures

  7. A Systems Modeling Approach to Forecast Corn Economic Optimum Nitrogen Rate

    Directory of Open Access Journals (Sweden)

    Laila A. Puntel

    2018-04-01

    years to forecast (RRMSE was on average 3% lower. Overall, the proposed approach of using the crop model as a forecasting tool could improve year-to-year predictability of corn yields and optimum N rates. Further improvements in modeling and set-up protocols are needed toward more accurate forecast, especially for extreme weather years with the most significant economic and environmental cost.

  8. A Systems Modeling Approach to Forecast Corn Economic Optimum Nitrogen Rate

    Science.gov (United States)

    Puntel, Laila A.; Sawyer, John E.; Barker, Daniel W.; Thorburn, Peter J.; Castellano, Michael J.; Moore, Kenneth J.; VanLoocke, Andrew; Heaton, Emily A.; Archontoulis, Sotirios V.

    2018-01-01

    to forecast (RRMSE was on average 3% lower). Overall, the proposed approach of using the crop model as a forecasting tool could improve year-to-year predictability of corn yields and optimum N rates. Further improvements in modeling and set-up protocols are needed toward more accurate forecast, especially for extreme weather years with the most significant economic and environmental cost. PMID:29706974

  9. A Systems Modeling Approach to Forecast Corn Economic Optimum Nitrogen Rate.

    Science.gov (United States)

    Puntel, Laila A; Sawyer, John E; Barker, Daniel W; Thorburn, Peter J; Castellano, Michael J; Moore, Kenneth J; VanLoocke, Andrew; Heaton, Emily A; Archontoulis, Sotirios V

    2018-01-01

    years to forecast (RRMSE was on average 3% lower). Overall, the proposed approach of using the crop model as a forecasting tool could improve year-to-year predictability of corn yields and optimum N rates. Further improvements in modeling and set-up protocols are needed toward more accurate forecast, especially for extreme weather years with the most significant economic and environmental cost.

  10. Integrated Approach To The Analysis Of The Quality Of Socio-Economic Regional Development Governance

    Directory of Open Access Journals (Sweden)

    Roman Michailovich Kachalov

    2014-12-01

    Full Text Available Prospects of the methods of the analysis and improvement of quality of governance the socio-economic systems application, based conceptual provisions of the system theory of economics, multilevel stratification of the economic space and the operational economical risk management theory are considered. For mesoeconomics, the types of system resources of the economy are defined. Also, it is analyses the influence on the quality of governance socio-economic region development the disparity of different types of system economical resources. Potential possibilities of the improvement of quality of governance due to thinner stratification of economical space and improvement the interaction parameters of the main actors of regional economic space are revealed. Leaning on the operational theory of risk management, ways of justification of administrative, strategic decisions by identification of the relevant economic risk factors and on the basis of received information development the program of anti-risk measures are offered. The methodical solutions promoting successful introduction of considered tools in practice of regional government are proposed.

  11. Validation of ACE-FTS N2O measurements

    Directory of Open Access Journals (Sweden)

    G. P. Stiller

    2008-08-01

    Full Text Available The Atmospheric Chemistry Experiment (ACE, also known as SCISAT, was launched on 12 August 2003, carrying two instruments that measure vertical profiles of atmospheric constituents using the solar occultation technique. One of these instruments, the ACE Fourier Transform Spectrometer (ACE-FTS, is measuring volume mixing ratio (VMR profiles of nitrous oxide (N2O from the upper troposphere to the lower mesosphere at a vertical resolution of about 3–4 km. In this study, the quality of the ACE-FTS version 2.2 N2O data is assessed through comparisons with coincident measurements made by other satellite, balloon-borne, aircraft, and ground-based instruments. These consist of vertical profile comparisons with the SMR, MLS, and MIPAS satellite instruments, multiple aircraft flights of ASUR, and single balloon flights of SPIRALE and FIRS-2, and partial column comparisons with a network of ground-based Fourier Transform InfraRed spectrometers (FTIRs. Between 6 and 30 km, the mean absolute differences for the satellite comparisons lie between −42 ppbv and +17 ppbv, with most within ±20 ppbv. This corresponds to relative deviations from the mean that are within ±15%, except for comparisons with MIPAS near 30 km, for which they are as large as 22.5%. Between 18 and 30 km, the mean absolute differences for the satellite comparisons are generally within ±10 ppbv. From 30 to 60 km, the mean absolute differences are within ±4 ppbv, and are mostly between −2 and +1 ppbv. Given the small N2O VMR in this region, the relative deviations from the mean are therefore large at these altitudes, with most suggesting a negative bias in the ACE-FTS data between 30 and 50 km. In the comparisons with the FTIRs, the mean relative differences between the ACE-FTS and FTIR partial columns (which cover a mean altitude range of 14 to 27 km are within ±5.6% for eleven of the twelve contributing stations. This mean relative difference is negative at ten stations

  12. deletion polymorphism of ACE gene and Alzheimerв€™s disease

    African Journals Online (AJOL)

    Omayma M. Hassanin

    2014-06-27

    Jun 27, 2014 ... ease, 45 males and 39 females aged 65 ± 7 years from the Geriatric Department at Ain-Shams Uni- ..... alternative therapy provided by the ACE protein. .... enzyme (ACE) gene polymorphism in relation to physical perfor-.

  13. Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS.

    Science.gov (United States)

    Mladic, Marija; de Waal, Tessa; Burggraaff, Lindsey; Slagboom, Julien; Somsen, Govert W; Niessen, Wilfried M A; Manjunatha Kini, R; Kool, Jeroen

    2017-10-01

    This study presents an analytical method for the screening of snake venoms for inhibitors of the angiotensin-converting enzyme (ACE) and a strategy for their rapid identification. The method is based on an at-line nanofractionation approach, which combines liquid chromatography (LC), mass spectrometry (MS), and pharmacology in one platform. After initial LC separation of a crude venom, a post-column flow split is introduced enabling parallel MS identification and high-resolution fractionation onto 384-well plates. The plates are subsequently freeze-dried and used in a fluorescence-based ACE activity assay to determine the ability of the nanofractions to inhibit ACE activity. Once the bioactive wells are identified, the parallel MS data reveals the masses corresponding to the activities found. Narrowing down of possible bioactive candidates is provided by comparison of bioactivity profiles after reversed-phase liquid chromatography (RPLC) and after hydrophilic interaction chromatography (HILIC) of a crude venom. Additional nanoLC-MS/MS analysis is performed on the content of the bioactive nanofractions to determine peptide sequences. The method described was optimized, evaluated, and successfully applied for screening of 30 snake venoms for the presence of ACE inhibitors. As a result, two new bioactive peptides were identified: pELWPRPHVPP in Crotalus viridis viridis venom with IC 50  = 1.1 μM and pEWPPWPPRPPIPP in Cerastes cerastes cerastes venom with IC 50  = 3.5 μM. The identified peptides possess a high sequence similarity to other bradykinin-potentiating peptides (BPPs), which are known ACE inhibitors found in snake venoms.

  14. Angiotensin I - Converting Enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival

    DEFF Research Database (Denmark)

    Frederiksen, Henrik; Gaist, David; Bathum, Lise

    2003-01-01

    Studies of younger individuals have suggested an association between ACE genotype and physical and cognitive performance. Using a longitudinal study of elderly twins we studied the association between ACE genotype and physical and cognitive functioning and survival in old age.......Studies of younger individuals have suggested an association between ACE genotype and physical and cognitive performance. Using a longitudinal study of elderly twins we studied the association between ACE genotype and physical and cognitive functioning and survival in old age....

  15. Molecular and Recombinational Mapping of Mutations in the Ace Locus of Drosophila melanogaster

    OpenAIRE

    Nagoshi, Rodney N.; Gelbart, William M.

    1987-01-01

    The Ace locus in Drosophila melanogaster is known to be the structural gene for acetylcholinesterase. Ace is located in a region of chromosome arm 3R which has been subjected to intensive genetic and molecular analysis. Previous deletion mapping studies have identified a 40-kb region within which the Ace gene resides. This report focuses on the further localization of Ace within this 40-kb interval. Within this region, selective fine structure recombinational analysis was employed to localize...

  16. Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease.

    Science.gov (United States)

    Wang, Wang; Patel, Vaibhav B; Parajuli, Nirmal; Fan, Dong; Basu, Ratnadeep; Wang, Zuocheng; Ramprasath, Tharmarajan; Kassiri, Zamaneh; Penninger, Josef M; Oudit, Gavin Y

    2014-08-01

    Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1-7 thereby negatively regulating the renin-angiotensin system. However, heart disease in humans and in animal models is associated with only a partial loss of ACE2. ACE2 is an X-linked gene; and as such, we tested the clinical relevance of a partial loss of ACE2 by using female ACE2(+/+) (wildtype) and ACE2(+/-) (heterozygote) mice. Pressure overload in ACE2(+/-) mice resulted in greater LV dilation and worsening systolic and diastolic dysfunction. These changes were associated with increased myocardial fibrosis, hypertrophy, and upregulation of pathological gene expression. In response to Ang II infusion, there was increased NADPH oxidase activity and myocardial fibrosis resulting in the worsening of Ang II-induced diastolic dysfunction with a preserved systolic function. Ang II-mediated cellular effects in cultured adult ACE2(+/-) cardiomyocytes and cardiofibroblasts were exacerbated. Ang II-mediated pathological signaling worsened in ACE2(+/-) hearts characterized by an increase in the phosphorylation of ERK1/2 and JNK1/2 and STAT-3 pathways. The ACE2(+/-) mice showed an exacerbated pressor response with increased vascular fibrosis and stiffness. Vascular superoxide and nitrotyrosine levels were increased in ACE2(+/-) vessels consistent with increased vascular oxidative stress. These changes occurred with increased renal fibrosis and superoxide production. Partial heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease secondary to pressure overload and Ang II infusion. Heart disease in humans with idiopathic dilated cardiomyopathy is associated with a partial loss of ACE2. Heterozygote female ACE2 mutant mice showed enhanced susceptibility to pressure overload-induced heart disease. Heterozygote female ACE2 mutant mice showed enhanced susceptibility to Ang II-induced heart and vascular diseases. Partial loss of ACE2 is sufficient to enhance the susceptibility to

  17. Economically optimal timing for crop disease control under uncertainty: an options approach

    NARCIS (Netherlands)

    Ndeffo Mbah, M.L.; Forster, G.; Wesseler, J.H.H.; Gilligan, C.A.

    2010-01-01

    Severe large-scale disease and pest infestations in agricultural regions can cause significant economic damage. Understanding if and when disease control measures should be taken in the presence of risk and uncertainty is a key issue. We develop a framework to examine the economically optimal timing

  18. Relationship between crimes and economic conditions in Pakistan: a time series approach

    NARCIS (Netherlands)

    Raja, Mohsin Gulzar; Ullah, Kafait

    2013-01-01

    Using the time series data from 1990-2011, this paper is an attempt to explore the relationship between economic conditions and criminal activities in Pakistan. Three variables are being used for economic conditions like increasing female employment in labor market, CPI which denotes inflation and

  19. Costs and benefits of controlling quarantine diseases : a bio-economic modeling approach

    NARCIS (Netherlands)

    Breukers, M.L.H.; Mourits, M.C.M.; Werf, van der W.; Oude Lansink, A.G.J.M.

    2008-01-01

    This article describes a bio-economic model to quantify the costs and benefits of controlling plant quarantine diseases. The model integrates the epidemiology and economic consequences of a quarantine disease. It allows for ex ante evaluation of control scenarios for their cost-effectiveness, taking

  20. Engaging Health Professionals in Health Economics: A Human Capital Informed Approach for Adults Learning Online

    Science.gov (United States)

    Lieberthal, Robert D.; Leon, Juan

    2015-01-01

    The authors describe a Wikipedia-based project designed for a graduate course introducing health economics to experienced healthcare professionals. The project allows such students to successfully write articles on niche topics in rapidly evolving health economics subspecialties. These students are given the opportunity to publish their completed…

  1. Regional economic activity and absenteeism: a new approach to estimating the indirect costs of employee productivity loss.

    Science.gov (United States)

    Bankert, Brian; Coberley, Carter; Pope, James E; Wells, Aaron

    2015-02-01

    This paper presents a new approach to estimating the indirect costs of health-related absenteeism. Productivity losses related to employee absenteeism have negative business implications for employers and these losses effectively deprive the business of an expected level of employee labor. The approach herein quantifies absenteeism cost using an output per labor hour-based method and extends employer-level results to the region. This new approach was applied to the employed population of 3 health insurance carriers. The economic cost of absenteeism was estimated to be $6.8 million, $0.8 million, and $0.7 million on average for the 3 employers; regional losses were roughly twice the magnitude of employer-specific losses. The new approach suggests that costs related to absenteeism for high output per labor hour industries exceed similar estimates derived from application of the human capital approach. The materially higher costs under the new approach emphasize the importance of accurately estimating productivity losses.

  2. The application of new economic and ecological approaches to energetics in Czechoslovakia

    International Nuclear Information System (INIS)

    Libich, V.; Kadrnozka, J.; Drahos, I.

    1986-10-01

    Orientation on local low-grade coal and nuclear sources also for heat supply, with which the construction of large heating systems and heat transport on large distances is connected, these are specific features of energy economy in Czechoslovakia. The development programme is challenging in economic respect, it causes numerous ecological problems, as well as those connected with coverage of variable loads. In case of additional construction at a later date many problems appear requiring differentiated approach that depends on concrete conditions. In the paper there are described possibilities and conditions of heat accumulation in feed water, in gravity accumulators at very quick changes of output, the accumulation systems involving steam release facilities and heat accumulation in heat conducting systems. Also the manufacture of heat generating equipment has an important role to play. There are given the outlines of construction of hot water accumulators. Specific conditions of the Czechoslovak energy economy also include the problem of efficient combustion of low-grade coal with a high sulfur content. In this connection it is especially the fluidized bed combustion that is under consideration. This combustion process can be run by clinkering of ash particles or a klinkerless process can be used. The combustion process can be either single-stage or double-stage. All these combustion methods are used in boilers made in Czechoslovakia. In the paper two types of boilers are described: the boiler with cooled fluidized bed and the fluidized bed reactor installed in front of a powdered coal fired boiler. There is briefly outlined the experience obtained from the operation of these boilers

  3. The Social System Approach to Institutions: Examples from Western Economic History

    Directory of Open Access Journals (Sweden)

    Solomon I. Cohen

    2016-09-01

    Full Text Available While there is a general acceptance of a broad definition of social institutions as accepted rules of conduct in agent interactions, there are overlapping views on how institutions come into being and develop. Different views see institutions as the result of evolution, contract, convention, game theory, political power, or legal necessity. Once created, institutions can live their own life and gain influence on the whole economy/society in respects beyond their intrinsic origins. The overlapping views give the impression of pursued piecemeal approaches in addressing the issues. Treating issues of institutional formation and development in the framework of social system theory and analysis can be shown to simplify the picture appreciably and bring more insight. This paper intends to do that. It will display and apply the social system perspective to understanding institutional formation and development. The paper falls in two sections. First, it develops an analytical framework that views the economy as a social system with interactive subsystems that initiate and maintain their own subsystem institutions. Some subsystems expand faster than others, gaining more influence. Interaction of agents across subsystems facilitates the dominance of the more influential subsystem and the spread of the subsystem’s allied institutions to the whole social system. Second, the paper illustrates the validity of the social system perspective via reviewing a timeline that highlights the changing and evolving dominance of the major subsystems and their attached institutions in the economic history of the western world, and in particular, the interactions between the firm subsystem and the state subsystem.

  4. Effects of oil production on economic growth in Eurasian countries: Panel ARDL approach

    International Nuclear Information System (INIS)

    Bildirici, Melike Elif; Kayıkçı, Fazıl

    2013-01-01

    This study aims at analyzing the relationship between oil production and economic growth in major oil exporting Eurasian countries; Azerbaijan, Kazakhstan, Russian Federation and Turkmenistan for 1993–2010 periods. Empirical results reveal that oil production and economic growth are cointegrated for these countries. Furthermore, there is positive bi-directional causality between oil production and economic growth both in the long run and in the short run which supports the policies about investing in energy infrastructure. -- Highlights: ► Causality between economic growth and oil production is important for energy policies. ► Oil production and GDP are cointegrated for four oil exporting Eurasian countries. ► There is positive bi-directional causality between oil production and economic growth for these countries.

  5. Evaluation of trade influence on economic growth rate by computational intelligence approach

    Science.gov (United States)

    Sokolov-Mladenović, Svetlana; Milovančević, Milos; Mladenović, Igor

    2017-01-01

    In this study was analyzed the influence of trade parameters on the economic growth forecasting accuracy. Computational intelligence method was used for the analyzing since the method can handle highly nonlinear data. It is known that the economic growth could be modeled based on the different trade parameters. In this study five input parameters were considered. These input parameters were: trade in services, exports of goods and services, imports of goods and services, trade and merchandise trade. All these parameters were calculated as added percentages in gross domestic product (GDP). The main goal was to select which parameters are the most impactful on the economic growth percentage. GDP was used as economic growth indicator. Results show that the imports of goods and services has the highest influence on the economic growth forecasting accuracy.

  6. Methodological Challenges to Economic Evaluations of Vaccines: Is a Common Approach Still Possible?

    Science.gov (United States)

    Jit, Mark; Hutubessy, Raymond

    2016-06-01

    Economic evaluation of vaccination is a key tool to inform effective spending on vaccines. However, many evaluations have been criticised for failing to capture features of vaccines which are relevant to decision makers. These include broader societal benefits (such as improved educational achievement, economic growth and political stability), reduced health disparities, medical innovation, reduced hospital beds pressures, greater peace of mind and synergies in economic benefits with non-vaccine interventions. Also, the fiscal implications of vaccination programmes are not always made explicit. Alternative methodological frameworks have been proposed to better capture these benefits. However, any broadening of the methodology for economic evaluation must also involve evaluations of non-vaccine interventions, and hence may not always benefit vaccines given a fixed health-care budget. The scope of an economic evaluation must consider the budget from which vaccines are funded, and the decision-maker's stated aims for that spending to achieve.

  7. Estimating Potential GDP for the Romanian Economy and Assessing the Sustainability of Economic Growth: A Multivariate Filter Approach

    Directory of Open Access Journals (Sweden)

    Dan Armeanu

    2015-03-01

    Full Text Available In the current context of economic recovery and rebalancing, the necessity of modelling and estimating the potential output and output gap emerges in order to assess the quality and sustainability of economic growth, the monetary and fiscal policies, as well as the impact of business cycles. Despite the importance of potential GDP and the output gap, there are difficulties in reliably estimating them, as many of the models proposed in the economic literature are calibrated for developed economies and are based on complex macroeconomic relationships and a long history of robust data, while emerging economies exhibit high volatility. The object of this study is to develop a model in order to estimate the potential GDP and output gap and to assess the sustainability of projected growth using a multivariate filter approach. This trend estimation technique is the newest approach proposed by the economic literature and has gained wide acceptance with researchers and practitioners alike, while also being used by the IMF for Romania. The paper will be structured as follows. We first discuss the theoretical background of the model. The second section focuses on an analysis of the Romanian economy for the 1995–2013 time frame, while also providing a forecast for 2014–2017 and an assessment of the sustainability of Romania’s economic growth. The third section sums up the results and concludes.

  8. Adopting a farming systems research approach to carry out an economic and environmental analysis of food supply chains

    DEFF Research Database (Denmark)

    Tavella, Elena; Pedersen, Søren Marcus; Gylling, Morten

    2012-01-01

    Agricultural systems are complex, because managers need to cope with interlinked and dynamic ecological, social, political and economic aspects. Understanding and analysing such systems requires researchers to adopt a holistic approach to grasp the links between those aspects. Holistic approaches...... within agricultural research - known as Farming Systems Research (FSR) support researchers in sharing knowledge and different perspectives concerning the research process and problems. Sharing knowledge and perspectives enables to holistically understand and conceptualise complex systems, as well...... as to structure and manage research projects. The aim of this paper is to suggest and present a guideline for agricultural researchers to carry out an economic and environmental analysis of food supply chains with a FSR approach. We describe how participants of the EU-project SOLIBAM (Strategies for Organic...

  9. Differential ACE expression among tissues in allele-specific Wistar rat lines

    NARCIS (Netherlands)

    Kamilic, Jelena; Lely, A. Titia; van Goor, Harry; Buikema, Hendrik; Tent, Hilde; Navis, Gerjan J.; Korstanje, Ron

    In humans, the insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene accounts for half of the variance in plasma ACE activity. The deletion allele is associated with high plasma ACE activity, cardiovascular disease, and renal disease. In rat, a similar association is found

  10. 21 CFR 862.1090 - Angiotensin converting enzyme (A.C.E.) test system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Angiotensin converting enzyme (A.C.E.) test system... Test Systems § 862.1090 Angiotensin converting enzyme (A.C.E.) test system. (a) Identification. An angiotensin converting enzyme (A.C.E.) test system is a device intended to measure the activity of angiotensin...

  11. CAUSAL RELATIONSHIP BETWEEN ENERGY CONSUMPTION, ECONOMIC GROWTH AND CO2 EMISSIONS: A DYNAMIC PANEL DATA APPROACH

    Directory of Open Access Journals (Sweden)

    Chaido Dritsaki

    2014-04-01

    Full Text Available Energy plays an important role in economic development worldwide. The increase of energy consumption showed that CO2 emissions in the atmosphere have increased dramatically, and these lead many scientists to push governments of the developing countries to take action for the formulation of environmental policies. Many studies have attempted to look for the direction of causality between energy consumption (EC, economic growth (GDP and CO2 emissions mainly on developing countries. This paper, therefore, applies the panel unit root tests, panel cointegration methods and panel causality test to investigate the relationship between energy consumption (EC, economic growth (GDP and CO2 emissions for three countries of Southern Europe (Greece, Spain, and Portugal covering the annual period 1960-2009. The FMOLS and DOLS are then used to estimate the long run relationship between the variables. The findings of this study reveal that there is a short-run bilateral causal link between the examined variables. However, in the long run, there is a unidirectional causality running from CO2 emissions to energy consumption (EC, and economic growth (GDP and a bilateral causality between energy consumption and economic growth. This indicates that energy is a force for economic growth both in short and long run as it is driven from economic growth. Moreover, to face the heterogeneity on the three countries of Southern Europe we use the FMOLS and DOLS estimation methods.

  12. Interaction in agent-based economics: A survey on the network approach

    Science.gov (United States)

    Bargigli, Leonardo; Tedeschi, Gabriele

    2014-04-01

    In this paper we aim to introduce the reader to some basic concepts and instruments used in a wide range of economic networks models. In particular, we adopt the theory of random networks as the main tool to describe the relationship between the organization of interaction among individuals within different components of the economy and overall aggregate behavior. The focus is on the ways in which economic agents interact and the possible consequences of their interaction on the system. We show that network models are able to introduce complex phenomena in economic systems by allowing for the endogenous evolution of networks.

  13. Developing a Community-Wide Initiative to Address Childhood Adversity and Toxic Stress: A Case Study of The Philadelphia ACE Task Force.

    Science.gov (United States)

    Pachter, Lee M; Lieberman, Leslie; Bloom, Sandra L; Fein, Joel A

    The Philadelphia ACE Task Force is a community based collaborative of health care providers, researchers, community-based organizations, funders, and public sector representatives. The mission of the task force is to provide a venue to address childhood adversity and its consequences in the Philadelphia metropolitan region. In this article we describe the origins and metamorphosis of the Philadelphia ACE Task Force, which initially was narrowly focused on screening for adverse childhood experiences (ACEs) in health care settings but expanded its focus to better represent a true community-based approach to sharing experiences with addressing childhood adversity in multiple sectors of the city and region. The task force has been successful in developing a research agenda and conducting research on ACEs in the urban context, and has identified foci of local activity in the areas of professional training and workforce development, community education, and local practical interventions around adversity, trauma, and resiliency. In this article we also address the lessons learned over the first 5 years of the task force's existence and offers recommendations for future efforts to build a local community-based ACEs collaborative. Copyright © 2017 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  14. Fatal angioedema induced by angiotensin conversion enzyme (ACE ...

    African Journals Online (AJOL)

    ACE inhibitors are often prescribed in the treatment of hypertension, heart failure and kidney disease. These drugs are on the Essential Drugs List, and are therefore used at primary to tertiary health care levels in South Africa. Angioedema is considered a rare, but potentially fatal side-effect of this agent, with a reported ...

  15. Development of Antennas for Subsurface Radars within ACE

    DEFF Research Database (Denmark)

    Yarovoy, Alexander; Meincke, Peter; Dauvignac, Jean-Yves

    2007-01-01

    The paper gives an overview of the joint activities of the ACE-2 partners in the area of antennas for surface penetrating radar. Main areas of joint research and development are discussed and main results of joint activities are presented. Special attention is given to experimental verification...

  16. Lack of association between two ACE gene polymorphisms (rs4291 ...

    African Journals Online (AJOL)

    Alzheimer's disease (AD) is a prevalent disorder and the most common cause of dementia in elderly populations. Genetic and environmental factors together play a role in developing late onset Alzheimer's disease (LOAD). According to the recent published papers, ACE is one of the candidate susceptibility genes for LOAD.

  17. Export and Economic Growth Nexus in the GCC Countries: A panel Data Approach

    Directory of Open Access Journals (Sweden)

    hatem Hatef abdulkadhim

    2017-12-01

    Full Text Available The export and economic growth nexus, which is called Balassa’s Export-Led Growth Hypothesis (ELGH  in the literature, is still an unstill issue in both the theoretical and empirical literature. In the present study, the effect of export on economic growth in  oil exporting developing countries, namely, Bahrain, Saudi Arabia, Qatar,  Kuwait, UAE, and Oman in the 1990–2014 period was tested based on three models, pooled ordinary least squares (POLS, fixed effects model (FEM, and random effects model (REM  via panel data analysis . The findings revealed strong support for the “export-led growth” hypothesis. In addition, our results show that apart from growth in the labor force, investments in capital formation are necessary for economic growth. According to the obtained results, the ability to adopt technological changes in order to increase efficiency, and sustain economic development is also important.

  18. Estimating the economic impact of tourism industry through the MM approach

    Directory of Open Access Journals (Sweden)

    SOCCI Claudio

    2017-01-01

    Full Text Available Tourism is one of the fastest growing industries in Italy and has proven to be a valuable source of economic prosperity. The main issue emerging when measuring the impact of tourism is that tourism is usually considered as a specific industry while in most applied situations it shows traits of a complex and structured economic activity characterized by a blend of different industries. We will identify the relationship among the various industries making up the complex economic activity usually referred as the “tourism industry”. This is done through the application of the multisectoral analysis to the Italian case. The evaluation of tourism in terms of economic policy is performed through the definition of an index of interaction among industries.

  19. THE EUROPEAN UNION’S QUEST FOR ENERGY POLICY: A GEO-ECONOMIC APPROACH

    Directory of Open Access Journals (Sweden)

    Alin Codoban

    2011-09-01

    Full Text Available The European Union’s external energy policy architecture is very important for further energy security and economic development. European normative power on its neighbours represents the most efficient way of integrating neighbouring energy markets, with the EU’s emerging internal market and, in perspective, through economic interdependence and complementarities, there are chances of creating an European geo-energy space. EU’s tools for shaping the geo-energy space are becoming more effective in an extended European economic area that would allow it to act as the main actor in a multilateral interconnected system of energy producer and transit countries. The result of the paper is materialized in a new paradigm for EU’s external energy policy, which can provide future security of supply through market institutions and an active economic diplomacy in the resource energy countries.

  20. A Modified Approach to the Introductory Economics Course in a School of Business

    Science.gov (United States)

    Crockett, G. V.

    1977-01-01

    Describes course format, materials development, and evaluation of an introductory economics course which stressed problem solving techniques and conceptual skills instead of rote memorization of factual content. For journal availability, see SO 506 029. (AV)

  1. Efficiency improvement for a sustainable agriculture : the integration of agronomic and farm economics approaches

    NARCIS (Netherlands)

    Koeijer, de T.J.

    2002-01-01

    Keywords: Sustainable farming systems, Agronomic efficiency, Economic efficiency, Environmental efficiency, Sustainability index, Interdisciplinary analysis.

    The objective of the research described in this thesis was to determine what role improved agronomic efficiency can play in

  2. Economic evaluations of pharmacogenetic approaches in infectious diseases: a review of current approaches and evaluation of critical aspects affecting their quality

    Directory of Open Access Journals (Sweden)

    Paolo Meoni

    2013-11-01

    Full Text Available Pharmacogenetics holds great potential for improving the effectiveness of treatment modalities in infectious diseases by taking into account the genetic determinants of both the host and infectious agents’ individuality. Better utilization of resources and improved therapeutic efficiency are the expected outcomes of personalized medicine using pharmacogenetic and pharmacogenomics information made available by technological advances. However, there has been growing concern in the clinical community regarding the evaluation of the true benefits of these approaches. This perception is partly due to the limited number and perceived poor quality of economic evaluations in this field, and initiatives aimed at harmonizing and communicating strategies improving the quality of these studies and their acceptance by the clinical community are greatly needed. This paper reviews current literature of economic evaluations of pharmacogenetics interventions guiding pharmacotherapy in infectious diseases. PubMed and the NHS Centre for Reviews and Dissemination databases were searched using a combination of five broad research terms related to pharmacogenetic approaches, and papers relative to economic evaluations of pharmacogenetic interventions in infectious diseases retained for further analysis. Using these criteria, a total of 14 papers were included in this review. The area of economic evaluation of pharmacogenetic interventions in infectious diseases remains understudied and would benefit from greater harmonization. The main weaknesses of evaluations reviewed in this paper seem to be represented by poor evidence of pharmacogenetic marker validation, inconsistencies in the selection of costs and utility included in the economic models and the choice of sensitivity analysis. All these factors limit the overall transparency of the studies, greater acceptance of their results and applicability to diverse and possibly resourcelimited environments where these

  3. FUNDAMENTAL ECONOMIC STRUCTURE AND STRUCTURAL CHANGE IN REGIONAL ECONOMIES: A METHODOLOGICAL APPROACH

    OpenAIRE

    Sudhir K. THAKUR

    2011-01-01

    Regional economic structure is defined as the composition and patterns of various components of the regional economy such as: produc-tion, employment, consumption, trade, and gross regional product. Structur-al change is conceptualized as the change in relative importance of the aggregate indicators of the economy. The process of regional development and structural change are intertwined, implying as economic development takes place the strength and direction of intersectoral relationships ch...

  4. CONSUMER’S BEHAVIOUR – AN APPROACH FROM THE PERSPECTIVE OF BEHAVIOURAL ECONOMICS

    Directory of Open Access Journals (Sweden)

    Viorel CORNESCU

    2015-07-01

    Full Text Available The consumer and his behaviour have concerned all economists, no matter if they are theoreticians or practitioners. Naturally, research in the domain has revealed new aspects, new theories and has led to the creation of schools of thought in time. Standard or neo-classic economics, which lays stress on absolute rationality, the maximization of results, modelling etc., cannot wholly decipher economic mechanisms or efficiently explain and guide the economic life of society. That is why, if we take as a starting point the observation that man lies at the heart of economy, we understand that the attempts to explain his role and the manner in which he behaves in economic life are more and more numerous and involve the use of concepts from different domains of study: psychology, sociology, etc. The present study aims at analysing the consumer’s behaviour from a perspective which already has a consistent and well-outlined profile in the economic science and is known as behavioural economics.

  5. Determining the Real Causes of Financial Crisis in Islamic Economic Perspective: ANP Approach

    Directory of Open Access Journals (Sweden)

    . Ascarya

    2016-04-01

    Full Text Available Objective – The purpose of this study is to determine the real causes of financial crisis from Islamic economic perspective.Methods - This study applies Analytic Network Process (ANP to determine the real causes of financial crisis from Islamic economic perspective to be able to formulate the real solutions to end financial crisis.Results - The ANP results show that the real causes of financial crisis from Islamic economic perspective are Social Instability (EXTERNAL FACTOR, Speculation (MISBEHAVIOR, Ineffective Fiscal System (UNSUSTAINABLE FISCAL SYSTEM, Hedonism (MISBEHAVIOR, Fractional Reserve Banking System (UNSTABLE MONETARY SYSTEM, Political Instability (EXTERNAL FACTOR, Corruption (POOR GOVERNANCE, Interest Rate (UNSTABLE MONETARY SYSTEM, Fiat Money (UNSTABLE MONETARY SYSTEM, and the Wrong Man in the Wrong Place (POOR GOVERNANCE. These main real causes should be removed gradually in order to systematically and gradually improve the stability of financial system so that financial crisis will not reappear again and again in the future.Conclusions - Financial crisis would not happen under Islamic economic system if all Allah’s laws in financial dealings were followed. Financial crisis in conventional economic system could be prevented or lessened by gradually adopting Islamic economic and finance laws and regulations, partly or fully, especially the main pillars of Islamic financial system, namely the prohibition of ribā (usury or interest, prohibition of maysir (gambling and game of chance or speculation and prohibition of gharar (excessive uncertainty, in their many forms.

  6. Modelling the role of forests on water provision services: a hydro-economic valuation approach

    Science.gov (United States)

    Beguería, S.; Campos, P.

    2015-12-01

    Hydro-economic models that allow integrating the ecological, hydrological, infrastructure, economic and social aspects into a coherent, scientifically- informed framework constitute preferred tools for supporting decision making in the context of integrated water resources management. We present a case study of water regulation and provision services of forests in the Andalusia region of Spain. Our model computes the physical water flows and conducts an economic environmental income and asset valuation of forest surface and underground water yield. Based on available hydrologic and economic data, we develop a comprehensive water account for all the forest lands at the regional scale. This forest water environmental valuation is integrated within a much larger project aiming at providing a robust and easily replicable accounting tool to evaluate yearly the total income and capital of forests, encompassing all measurable sources of private and public incomes (timber and cork production, auto-consumption, recreational activities, biodiversity conservation, carbon sequestration, water production, etc.). We also force our simulation with future socio-economic scenarios to quantify the physical and economic efects of expected trends or simulated public and private policies on future water resources. Only a comprehensive integrated tool may serve as a basis for the development of integrated policies, such as those internationally agreed and recommended for the management of water resources.

  7. Economic cooperation between Russia and North Korea: New goals and new approaches

    Directory of Open Access Journals (Sweden)

    Liudmila Zakharova

    2016-07-01

    Full Text Available For many years the Soviet Union was the key economic partner of North Korea. After the USSR broke up, Russia has not played such an important role in the DPRK's economic development. In 2013, its share in the foreign trade of North Korea accounted for a mere 1%. However, in the second decade of the 21st century bilateral, contacts have intensified significantly. Judging by the recent developments, the Russian leadership has made a political decision to expand economic cooperation with North Korea and stimulate Russia's business interests with the DPRK. Russia has set a goal of growing the volume of its trade with North Korea by a factor of ten by 2020. Moreover, Moscow is currently developing a number of investment projects in the DPRK and Russian companies are also looking at developing more of them. Another important aim for Russia is the implementation of big infrastructure projects with both Koreas. The article examines the current position and future prospects for economic cooperation between Russia and North Korea and analyses main forms and potential opportunities for developing bilateral economic relations. Particular attention is paid to the expanding cooperation mechanisms and joint economic projects between Russia and the DPRK and also the potential participation of the Republic of Korea.

  8. Interactions between electricity generation sources and economic activity in Greece: A VECM approach

    International Nuclear Information System (INIS)

    Marques, António Cardoso; Fuinhas, José Alberto; Menegaki, Angeliki N.

    2014-01-01

    Highlights: • Adjustment dynamics in electricity sources and industrial production are examined. • The Johansen’s method with a conditional VEC model was pursued. • Results confirm endogeneity among variables. • Cointegration relationships for fossil and for renewables sources were founded. • Renewables are less affected by disturbance in economic activity. - Abstract: The interactions between electricity generation sources and industrial production in Greece were analysed from August 2004 to October 2013. Greece has been subject to a tough economic adjustment under external financial assistance guidelines. In the meantime, the country has remained committed to international agreements concerning the use of renewables. The variables interact with each other, and this endogeneity has been analysed using a VECM model. A short-run, causal relationship from conventional fossil sources to economic growth, was proved. However, there is no evidence of causal relationships from renewable electricity to economic growth, either in the short- or long-run. Only economic growth gives rise to renewable electricity, whether in the short- or long-run. A fresh insight on the current state of dynamics between electricity sources within an electricity generation system, is thus added to the literature. These findings will inform energy policymakers in designing policies both to encourage the incorporation of national technology into renewables and to reduce electricity consumption without hampering economic growth

  9. Sanus-Ace: Negotiating a Memorandum of Understanding in external corporate venturing.

    OpenAIRE

    VANHAVERBEKE, Wim

    2014-01-01

    This negotiation case describes a situation in which an investment manager of a large chemical company (ACE) has to decide about a corporate venturing investment in a small high-tech start-up (Sanus). To win board approval for this investment, an ACE business unit (in this case, ACE Food Specialties) must write a letter of commitment. The investment manager of ACE Venturing cannot invest in the start-up without a MoU between the start-up and the business unit of ACE. This case provides the re...

  10. A systematic review of modelling approaches in economic evaluations of health interventions for drug and alcohol problems.

    Science.gov (United States)

    Hoang, Van Phuong; Shanahan, Marian; Shukla, Nagesh; Perez, Pascal; Farrell, Michael; Ritter, Alison

    2016-04-13

    The overarching goal of health policies is to maximize health and societal benefits. Economic evaluations can play a vital role in assessing whether or not such benefits occur. This paper reviews the application of modelling techniques in economic evaluations of drug and alcohol interventions with regard to (i) modelling paradigms themselves; (ii) perspectives of costs and benefits and (iii) time frame. Papers that use modelling approaches for economic evaluations of drug and alcohol interventions were identified by carrying out searches of major databases. Thirty eight papers met the inclusion criteria. Overall, the cohort Markov models remain the most popular approach, followed by decision trees, Individual based model and System dynamics model (SD). Most of the papers adopted a long term time frame to reflect the long term costs and benefits of health interventions. However, it was fairly common among the reviewed papers to adopt a narrow perspective that only takes into account costs and benefits borne by the health care sector. This review paper informs policy makers about the availability of modelling techniques that can be used to enhance the quality of economic evaluations for drug and alcohol treatment interventions.

  11. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats.

    Science.gov (United States)

    Abuohashish, Hatem M; Ahmed, Mohammed M; Sabry, Dina; Khattab, Mahmoud M; Al-Rejaie, Salim S

    2017-08-01

    The local role of the renin angiotensin system (RAS) was documented recently beside its conventional systemic functions. Studies showed that the effector angiotensin II (AngII) alters bone health, while inhibition of the angiotensin converting enzyme (ACE-1) preserved these effects. The newly identified Ang1-7 exerts numerous beneficial effects opposing the AngII. Thus, the current study examines the role of Ang1-7 in mediating the osteo-preservative effects of ACEI (captopril) through the G-protein coupled Mas receptor using an ovariectomized (OVX) rat model of osteoporosis. 8 weeks after the surgical procedures, captopril was administered orally (40mgkg -1 d -1 ), while the specific Mas receptor blocker (A-779) was delivered at infusion rate of 400ngkg -1 min -1 for 6 weeks. Bone metabolic markers were measured in serum and urine. Minerals concentrations were quantified in serum, urine and femoral bones by inductive coupled plasma mass spectroscopy (ICP-MS). Trabecular and cortical morphometry was analyzed in the right distal femurs using micro-CT. Finally, the expressions of RAS peptides, enzymes and receptors along with the receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) were determined femurs heads. OVX animals markedly showed altered bone metabolism and mineralization along with disturbed bone micro-structure. Captopril significantly restored the metabolic bone bio-markers and corrected Ca 2+ and P values in urine and bones of estrogen deficient rats. Moreover, the trabecular and cortical morphometric features were repaired by captopril in OVX groups. Captopril also improved the expressions of ACE-2, Ang1-7, Mas and OPG, while abolished OVX-induced up-regulation of ACE-1, AngII, Ang type 1 receptor (AT1R) and RANKL. Inhibition of Ang1-7 cascade by A-779 significantly eradicated captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restored OVX effects on RANKL expression and ACE-1/AngII/AT1R

  12. Evaluating the efficiency of divestiture policy in promoting competitiveness using an analytical method and agent-based computational economics

    Energy Technology Data Exchange (ETDEWEB)

    Rahimiyan, Morteza; Rajabi Mashhadi, Habib [Department of Electrical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad (Iran)

    2010-03-15

    Choosing a desired policy for divestiture of dominant firms' generation assets has been a challenging task and open question for regulatory authority. To deal with this problem, in this paper, an analytical method and agent-based computational economics (ACE) approach are used for ex-ante analysis of divestiture policy in reducing market power. The analytical method is applied to solve a designed concentration boundary problem, even for situations where the cost data of generators are unknown. The concentration boundary problem is the problem of minimizing or maximizing market concentration subject to operation constraints of the electricity market. It is proved here that the market concentration corresponding to operation condition is certainly viable in an interval calculated by the analytical method. For situations where the cost function of generators is available, the ACE is used to model the electricity market. In ACE, each power producer's profit-maximization problem is solved by the computational approach of Q-learning. The power producer using the Q-learning method learns from past experiences to implicitly identify the market power, and find desired response in competing with the rivals. Both methods are applied in a multi-area power system and effects of different divestiture policies on market behavior are analyzed. (author)

  13. Evaluating the efficiency of divestiture policy in promoting competitiveness using an analytical method and agent-based computational economics

    International Nuclear Information System (INIS)

    Rahimiyan, Morteza; Rajabi Mashhadi, Habib

    2010-01-01

    Choosing a desired policy for divestiture of dominant firms' generation assets has been a challenging task and open question for regulatory authority. To deal with this problem, in this paper, an analytical method and agent-based computational economics (ACE) approach are used for ex-ante analysis of divestiture policy in reducing market power. The analytical method is applied to solve a designed concentration boundary problem, even for situations where the cost data of generators are unknown. The concentration boundary problem is the problem of minimizing or maximizing market concentration subject to operation constraints of the electricity market. It is proved here that the market concentration corresponding to operation condition is certainly viable in an interval calculated by the analytical method. For situations where the cost function of generators is available, the ACE is used to model the electricity market. In ACE, each power producer's profit-maximization problem is solved by the computational approach of Q-learning. The power producer using the Q-learning method learns from past experiences to implicitly identify the market power, and find desired response in competing with the rivals. Both methods are applied in a multi-area power system and effects of different divestiture policies on market behavior are analyzed.

  14. The relationship between CO2 emission, energy consumption and economic growth in Malaysia: a three-way linkage approach.

    Science.gov (United States)

    Sulaiman, Chindo; Abdul-Rahim, A S

    2017-11-01

    This study examines the three-way linkage relationships between CO 2 emission, energy consumption and economic growth in Malaysia, covering the 1975-2015 period. An autoregressive distributed lag approach was employed to achieve the objective of the study and gauged by dynamic ordinary least squares. Additionally, vector error correction model, variance decompositions and impulse response functions were employed to further examine the relationship between the interest variables. The findings show that economic growth is neither influenced by energy consumption nor by CO 2 emission. Energy consumption is revealed to be an increasing function of CO 2 emission. Whereas, CO 2 emission positively and significantly depends on energy consumption and economic growth. This implies that CO 2 emission increases with an increase in both energy consumption and economic growth. Conclusively, the main drivers of CO 2 emission in Malaysia are proven to be energy consumption and economic growth. Therefore, renewable energy sources ought to be considered by policy makers to curb emission from the current non-renewable sources. Wind and biomass can be explored as they are viable sources. Energy efficiency and savings should equally be emphasised and encouraged by policy makers. Lastly, growth-related policies that target emission reduction are also recommended.

  15. Applying a System Dynamics Approach for Modeling Groundwater Dynamics to Depletion under Different Economical and Climate Change Scenarios

    Directory of Open Access Journals (Sweden)

    Hamid Balali

    2015-09-01

    Full Text Available In the recent decades, due to many different factors, including climate change effects towards be warming and lower precipitation, as well as some structural policies such as more intensive harvesting of groundwater and low price of irrigation water, the level of groundwater has decreased in most plains of Iran. The objective of this study is to model groundwater dynamics to depletion under different economic policies and climate change by using a system dynamics approach. For this purpose a dynamic hydro-economic model which simultaneously simulates the farmer’s economic behavior, groundwater aquifer dynamics, studied area climatology factors and government economical policies related to groundwater, is developed using STELLA 10.0.6. The vulnerability of groundwater balance is forecasted under three scenarios of climate including the Dry, Nor and Wet and also, different scenarios of irrigation water and energy pricing policies. Results show that implementation of some economic policies on irrigation water and energy pricing can significantly affect on groundwater exploitation and its volume balance. By increasing of irrigation water price along with energy price, exploitation of groundwater will improve, in so far as in scenarios S15 and S16, studied area’s aquifer groundwater balance is positive at the end of planning horizon, even in Dry condition of precipitation. Also, results indicate that climate change can affect groundwater recharge. It can generally be expected that increases in precipitation would produce greater aquifer recharge rates.

  16. Environmental and economic analysis of end of life management options for an HDPE product using a life cycle thinking approach.

    Science.gov (United States)

    Simões, Carla L; Pinto, Lígia M Costa; Bernardo, C A

    2014-05-01

    Manufacturers have been increasingly considering the implication of materials used in commercial products and the management of such products at the end of their useful lives (as waste or as post-consumer secondary materials). The present work describes the application of the life cycle thinking approach to a plastic product, specifically an anti-glare lamellae (used for road safety applications) made with high-density polyethylene (HDPE). This study shows that optimal environmental and economic outcomes associated with this product can be realized by recovering the material at the end of its useful life (end of life, EoL) and by using the recycled HDPE as a raw material in the production of new similar products. The study confirmed the applicability of the life cycle thinking approach by industry in sustainable products development, supporting the development of robust environmental and economic guidelines.

  17. Oil Price Volatility and Economic Growth in Nigeria: a Vector Auto-Regression (VAR Approach

    Directory of Open Access Journals (Sweden)

    Edesiri Godsday Okoro

    2014-02-01

    Full Text Available The study examined oil price volatility and economic growth in Nigeria linking oil price volatility, crude oil prices, oil revenue and Gross Domestic Product. Using quarterly data sourced from the Central Bank of Nigeria (CBN Statistical Bulletin and World Bank Indicators (various issues spanning 1980-2010, a non‐linear model of oil price volatility and economic growth was estimated using the VAR technique. The study revealed that oil price volatility has significantly influenced the level of economic growth in Nigeria although; the result additionally indicated a negative relationship between the oil price volatility and the level of economic growth. Furthermore, the result also showed that the Nigerian economy survived on crude oil, to such extent that the country‘s budget is tied to particular price of crude oil. This is not a good sign for a developing economy, more so that the country relies almost entirely on revenue of the oil sector as a source of foreign exchange earnings. This therefore portends some dangers for the economic survival of Nigeria. It was recommended amongst others that there should be a strong need for policy makers to focus on policy that will strengthen/stabilize the economy with specific focus on alternative sources of government revenue. Finally, there should be reduction in monetization of crude oil receipts (fiscal discipline, aggressive saving of proceeds from oil booms in future in order to withstand vicissitudes of oil price volatility in future.

  18. Review: Current Approaches to Business and Institutional Translation. Proceedings of the International Conference on Economic, Business, Financial and Institutional Translation

    Directory of Open Access Journals (Sweden)

    Miguel Tolosa Igualada

    2016-08-01

    Full Text Available Daniel Gallego-Hernández (ed.. Current Approaches to Business and Institutional Translation. Proceedings of the International Conference on Economic, Business, Financial and Institutional Translation / Enfoques actuales en traducción económica e institucional. Actas del Congreso Internacional de Traducción Económica, Comercial, Financiera e Institucional. Suíça: Peter Lang, 2015, 254 páginas. ISBN 978-3-0343-1656-9.

  19. Blood type gene locus has no influence on ACE association with Alzheimer's disease.

    Science.gov (United States)

    Braae, Anne; Medway, Christopher; Carrasquillo, Minerva; Younkin, Steven; Kehoe, Patrick G; Morgan, Kevin

    2015-04-01

    The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. An approach to optimize economics in a west Texas CO2 flood

    International Nuclear Information System (INIS)

    Pariani, G.J.; McColloch, K.A.; Warden, S.L.; Edens, D.R.

    1992-01-01

    Enhanced oil recovery projects, most notably CO 2 floods, are the next generation of recovery methods in the more mature West Texas waterfloods. The cost of installing and operating a CO 2 flood can be extremely high. In this paper, the authors will discuss the methods the authors used to make several active CO 2 floods more profitable by reducing operating costs and deferring investments. This paper reports that the author's goals in studying several active West Texas CO 2 floods were to determine the optimum near term cash flow, overall project economics (rate of return, present worth etc.) and oil recoveries. Using a reservoir simulator, various CO 2 flood designs were developed by altering specific operating parameters including the half-cycle slug size, gas-water ratio (GWR) injection schemes and total CO 2 slug sizes. The resulting injection and production rates were then entered into an economic simulator to determine the most economic set of operating conditions

  1. Financial Management of Economic Entity from the Perspective of Alternative Approach

    Directory of Open Access Journals (Sweden)

    Victor Munteanu

    2016-12-01

    Full Text Available Throughout the study the financial management presented is divided into three directions, namely financial analysis, financial planning and financial strategy, focusing on increasing the quality of financial management conducted at the economic entity by identifying an easier possible use for a system of alternative decisions in order to increase the profitability. The study also aims to identify new meanings of financial accounting information system in performing the managerial act through alternative decisions, trying to highlight the need to create a management tool generator of variants possible to be adopted with an impact on their application in the economic entity as a whole. Based on qualitative research on the financial management act, it is revealed the importance of the financial management act manifested in the economic entity and also its quality improvement through simulations targeting the management through budget system.

  2. Adaptive Differential Evolution Approach for Constrained Economic Power Dispatch with Prohibited Operating Zones

    Directory of Open Access Journals (Sweden)

    Abdellatif HAMOUDA

    2011-12-01

    Full Text Available Economic power dispatch (EPD is one of the main tools for optimal operation and planning of modern power systems. To solve effectively the EPD problem, most of the conventional calculus methods rely on the assumption that the fuel cost characteristic of a generating unit is a continuous and convex function, resulting in inaccurate dispatch. This paper presents the design and application of efficient adaptive differential evolution (ADE algorithm for the solution of the economic power dispatch problem, where the non-convex characteristics of the generators, such us prohibited operating zones and ramp rate limits of the practical generator operation are considered. The 26 bus benchmark test system with 6 units having prohibited operating zones and ramp rate limits was used for testing and validation purposes. The results obtained demonstrate the effectiveness of the proposed method for solving the non-convex economic dispatch problem.

  3. ACE genotype, phenotype and all-cause mortality in different cohorts of patients with type 1 diabetes

    DEFF Research Database (Denmark)

    Færch, Louise H; Sejling, Anne-Sophie; Lajer, Maria

    2015-01-01

    AIMS: Carrying the D-allele of the angiotensin-converting enzyme (ACE) I/D polymorphism and high ACE activity are prognostic factors in diabetic nephropathy, which predicts mortality in type 1 diabetes. We studied the association between the ACE D-allele and ACE phenotype and long-term all-cause ...

  4. Developing an Evaluation Tool for Assessing Clinical Ethics Consultation Skills in Simulation Based Education: The ACES Project.

    Science.gov (United States)

    Wasson, Katherine; Parsi, Kayhan; McCarthy, Michael; Siddall, Viva Jo; Kuczewski, Mark

    2016-06-01

    The American Society for Bioethics and Humanities has created a quality attestation (QA) process for clinical ethics consultants; the pilot phase of reviewing portfolios has begun. One aspect of the QA process which is particularly challenging is assessing the interpersonal skills of individual clinical ethics consultants. We propose that using case simulation to evaluate clinical ethics consultants is an approach that can meet this need provided clear standards for assessment are identified. To this end, we developed the Assessing Clinical Ethics Skills (ACES) tool, which identifies and specifies specific behaviors that a clinical ethics consultant should demonstrate in an ethics case simulation. The aim is for the clinical ethics consultant or student to use a videotaped case simulation, along with the ACES tool scored by a trained rater, to demonstrate their competence as part of their QA portfolio. The development and piloting of the tool is described.

  5. A Mixed Methods Approach to Equity and Justice Research: Insights from Research on Children's Reasoning About Economic Inequality.

    Science.gov (United States)

    Mistry, Rashmita S; White, Elizabeth S; Chow, Kirby A; Griffin, Katherine M; Nenadal, Lindsey

    2016-01-01

    Mixed methods research approaches are gaining traction across various social science disciplines, including among developmental scientists. In this chapter, we discuss the utility of a mixed methods research approach in examining issues related to equity and justice. We incorporate a brief overview of quantitative and qualitative monomethod research approaches in our larger discussion of the advantages, procedures, and considerations of employing a mixed methods design to advance developmental science from an equity and justice perspective. To better illustrate the theoretical and practical significance of a mixed methods research approach, we include examples of research conducted on children and adolescents' conceptions of economic inequality as one example of developmental science research with an equity and justice frame. © 2016 Elsevier Inc. All rights reserved.

  6. METHODOLOGICAL APPROACHES OF FORMATION OF ECONOMIC ADMINISTRATIVE COMPETENCE IN COLLEGE STUDENTS

    Directory of Open Access Journals (Sweden)

    Anna Lepeshkina

    2016-02-01

    Full Text Available The article discusses the teaching methods of discipline «Fundamentals of Economics, management and marketing» in secondary vocational education, presents a feature exploring the economic and managerial categories in the conditions of constant increase of volume of information. The work also addressed the role of independent work when studying discipline «Bases of economy, management and marketing», presents a method of working with text, and identifies the tools of academic and extracurricular activities, the application of which is effective for the study of the subject.

  7. Motor fuel taxation, energy conservation, and economic development: A regional approach

    International Nuclear Information System (INIS)

    England, Richard W.

    2007-01-01

    Combustion of motor fuels has a variety of environmental impacts on local, regional and global scales. Taxing motor fuels more heavily would mitigate those environmental impacts. However, many governments are reluctant to increase motor fuel taxes because they fear that the tax incidence will be regressive and that economic development will be impeded. Using data for the New England region of the United States, this paper argues that an oil-importing region can conserve energy, avoid regressive impacts and encourage economic development by taxing motor fuels more heavily and rebating the incremental revenues to owners of motor vehicles. (author)

  8. Economic expansion and increase in labout market formality: a poaching approach

    Directory of Open Access Journals (Sweden)

    Carlos Henrique L. Corseuil

    2012-06-01

    Full Text Available This paper investigates the relationship between economic expansion and the degree of formalization for the Brazilian labour market in the recent period. We present a theoretical framework that attempts to explain this relationship through the dynamics of firms hiring strategies. The main predictions are: the share of formal employment rises as the unemployment rate falls, and that the formal-informal wage gap increases, at least at the beginning of the economic expansion. In the empirical part, we use longitudinal microdata from a Brazilian household survey to check whether these two predictions are confirmed. To a large extent our results corroborate both predictions.

  9. Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.

    Science.gov (United States)

    Masud, Rizwan; Qureshi, Irfan Zia

    2011-09-01

    Cardiovascular disorders and coronary artery disease (CAD) are significant contributors to morbidity and mortality in heart patients. As genes of the folate/homocysteine pathway have been linked with the vascular disease, we investigated association of these gene polymorphisms with CAD/myocardial infarction (MI) using the novel approach of tetraprimer ARMS-PCR. A total of 230 participants (129 MI cases, 101 normal subjects) were recruited. We genotyped rs1801133 and rs1801131 SNPs in 5'10' methylenetetrahydrofolate reductase (MTHFR), rs1805087 SNP in 5' methyltetrahydrofolate homocysteine methyltransferase (MTR), rs662 SNP in paroxanse1 (PON1), and rs5742905 polymorphism in cystathionine beta synthase (CBS). Angiotensin converting enzyme (ACE) insertion/deletion polymorphism was detected through conventional PCR. Covariates included blood pressure, fasting blood sugar, serum cholesterol, and creatinine concentrations. Our results showed allele frequencies at rs1801133, rs1801131, rs1805087 and the ACE insertion/deletion (I/D) polymorphism varied between cases and controls. Logistic regression, after adjusting for covariates, demonstrated significant associations of rs1801133 and rs1805087 with CAD in the additive, dominant, and genotype model. In contrast, ACE I/D polymorphism was significantly related with CAD where recessive model was applied. Gene-gene interaction against the disease status revealed two polymorphism groups: rs1801133, rs662, and rs1805087; and rs1801131, rs662, and ACE I/D. Only the latter interaction maintained significance after adjusted for covariates. Our study concludes that folate pathway variants exert contributory influence on susceptibility to CAD. We further suggest that tetraprimer ARMS-PCR successfully resolves the genotypes in selected samples and might prove to be a superior technique compared to the conventional approach.

  10. The estimated economic burden of genital herpes in the United States. An analysis using two costing approaches

    Directory of Open Access Journals (Sweden)

    Fisman David N

    2001-06-01

    Full Text Available Abstract Background Only limited data exist on the costs of genital herpes (GH in the USA. We estimated the economic burden of GH in the USA using two different costing approaches. Methods The first approach was a cross-sectional survey of a sample of primary and secondary care physicians, analyzing health care resource utilization. The second approach was based on the analysis of a large administrative claims data set. Both approaches were used to generate the number of patients with symptomatic GH seeking medical treatment, the average medical expenditures and estimated national costs. Costs were valued from a societal and a third party payer's perspective in 1996 US dollars. Results In the cross-sectional study, based on an estimated 3.1 million symptomatic episodes per year in the USA, the annual direct medical costs were estimated at a maximum of $984 million. Of these costs, 49.7% were caused by drug expenditures, 47.7% by outpatient medical care and 2.6% by hospital costs. Indirect costs accounted for further $214 million. The analysis of 1,565 GH cases from the claims database yielded a minimum national estimate of $283 million direct medical costs. Conclusions GH appears to be an important public health problem from the health economic point of view. The observed difference in direct medical costs may be explained with the influence of compliance to treatment and possible undersampling of subpopulations in the claims data set. The present study demonstrates the validity of using different approaches in estimating the economic burden of a specific disease to the health care system.

  11. Schumacher and Kautilyan economics from an integral view : A sustainable approach

    NARCIS (Netherlands)

    Nandram, S.S.

    2013-01-01

    The world today is changing rapidly in many areas. On the macroeconomic level this is occurring in the form of climate change, resource depletion, disparity of wealth and possibilities of global nuclear waste. Several scholars express a need for a new paradigm of economics and management addressing

  12. Designing medical technology for resilience : integrating health economics and human factors approaches

    NARCIS (Netherlands)

    Borsci, Simone; Uchegbu, Ijeoma; Buckle, Peter; Ni, Zhifang; Walne, Simon; Hanna, George B.

    2018-01-01

    Introduction: The slow adoption of innovation into healthcare calls into question the manner of evidence generation for medical technology. This paper identifies potential reasons for this including a lack of attention to human factors, poor evaluation of economic benefits, lack of understanding of

  13. An Approach to Determining the Market for Academic Positions: Application to the Discipline of Agricultural Economics

    Science.gov (United States)

    Farrell, Terence; Casavant, Ken; Jessup, Eric

    2007-01-01

    The purpose of this paper is to present issues that are relevant to pursuing an academic career in the chosen discipline of each student. The application will be a general case study of agricultural economics. The analytical model will be used to evaluate options for Ph.D. graduates in a supply and demand context. The first issue presented is a…

  14. Methodological approach for assessing the economic impact of forest fires using MODIS remote sensing images

    Science.gov (United States)

    Francisco Rodríguez y Silva; Juan Ramón Molina Martínez; Miguel Castillo Soto

    2013-01-01

    Assessing areas affected by forest fires requires comprehensive studies covering a wide range of analyzes. From an economic standpoint, assessing the affected area in monetary terms is crucial. Determining the degree of loss in the value of natural resources, both those of a tangible and intangible nature, enables knowing the residual value remaining after a fire, i.e...

  15. Pyrolysis of forest residues: an approach to techno-economics for bio-fuel production

    Science.gov (United States)

    The techno-economics for producing liquid fuels from Maine forest residues were determined from a combination of: (1) laboratory experiments at USDA-ARS’s Eastern Regional Research Center using hog fuel (a secondary woody residue produced from mill byproducts such as sawdust, bark and shavings) as a...

  16. Indirect Evolution Versus Strategic Delegation : A Comparison of Two Approaches to Explaining Economic Institutions

    NARCIS (Netherlands)

    Dufwenberg, M.; Güth, W.

    1997-01-01

    The two major methods of explaining economic institutions, namely by strategic choices or by (indirect) evolution, are compared for the case of a homogenous quadratic duopoly market. Sellers either can provide incentives for their agents to care for sales (amounts) or evolve as sellers who care for

  17. Components of the costs of controlling quality: a transaction cost economics approach.

    Science.gov (United States)

    Stiles, R A; Mick, S S

    1997-01-01

    This article identifies the components that contribute to a healthcare organization's costs in controlling quality. A central tenet of our argument is that at its core, quality is the result of a series of transactions among members of a diverse network. Transaction cost economics is applied internally to analyze intraorganizational transactions that contribute to quality control, and questions for future research are posed.

  18. Sustainable Approaches for Materials Management in Remote, Economically Challenged Areas of the Pacific

    Science.gov (United States)

    Remote, economically challenged areas in the Commonwealth of the Northern Marianas Islands (CNMI) and American Samoa in the US Pacific island territories face unique challenges with respect to solid waste management. These islands are remote and isolated, with some islands suppo...

  19. Interbank Lending Decisions in An Economic Downturn: An Agent-Based Approach

    Directory of Open Access Journals (Sweden)

    Deddy P. Koesrindartoto

    2012-01-01

    Full Text Available Interbank lending is one mechanism that can make shock, which is accepted by one bank spread to other banks (contagion. There are several researchers that focused their research on analyzing the effect of interbank lending to systemic risk. However, there is a few research that analyzed the effect of banks’ decision maker’s behavior, especially on the bank interbank lending to the systemic risk. In this research, the author creates an agent-based  simulation of the banking system to analyze the effect of banks’ decision maker’s behavior to systemic risk in economic downturn condition. The preliminary result from this research is for an economic downturn in a long time period, the banking system with a low net worth to the asset's ratio threshold will produce more default bank than the banking system with a high net worth to the asset's ratio threshold. However, for an economic downturn in small time period, banking system which all bank in their system has the higher net worth to assets ratio threshold will have the default bank first than the banking system which has the lower net worth to the asset's ratio threshold. Keywords: agent-based simulation, banker behavior, interbank lending, economic downturn

  20. A current value Hamiltonian Approach for Discrete time Optimal Control Problems arising in Economic Growth

    OpenAIRE

    Naz, Rehana

    2018-01-01

    Pontrygin-type maximum principle is extended for the present value Hamiltonian systems and current value Hamiltonian systems of nonlinear difference equations for uniform time step $h$. A new method termed as a discrete time current value Hamiltonian method is established for the construction of first integrals for current value Hamiltonian systems of ordinary difference equations arising in Economic growth theory.

  1. When Child Development Meets Economic Game Theory: An Interdisciplinary Approach to Investigating Social Development

    Science.gov (United States)

    Gummerum, Michaela; Hanoch, Yaniv; Keller, Monika

    2008-01-01

    Game theory has been one of the most prominent theories in the social sciences, influencing diverse academic disciplines such as anthropology, biology, economics, and political science. In recent years, economists have employed game theory to investigate behaviors relating to fairness, reciprocity, and trust. Surprisingly, this research has not…

  2. The Economic Efficiency of European Football Clubs--Data Envelopment Analysis (DEA) Approach

    Science.gov (United States)

    Pyatunin, Aleksey V.; Vishnyakova, Angelina B.; Sherstneva, Natalia L.; Mironova, Svetlana P.; Dneprov, Sergey A.; Grabozdin, Yuriy P.

    2016-01-01

    The relevance of this paper lies in the fact that football business has grown significantly in the past 20 years and football clubs have become large companies, which in an effort to be profitable and successful on the field need to improve the efficiency of their business. The aim of this article is to measure economic efficiency of 48 big…

  3. Evaluating Effective Teaching in College Level Economics Using Student Ratings of Instruction: A Factor Analytic Approach

    Science.gov (United States)

    Agbetsiafa, Douglas

    2010-01-01

    This paper explores the factors that affect students' evaluation of economic instruction using a sample of 1300 completed rating instruments at a comprehensive four-year mid-western public university. The study uses factor analysis to determine the validity and reliability of the evaluation instrument in assessing instructor or course…

  4. User centric design of smart grid : A social and economical approach

    NARCIS (Netherlands)

    Kobus, C.B.A.; De Jonge, B.; Knigge, J.; Slootweg, J.G.

    2011-01-01

    The energy transition poses challenges for maintaining the energy balance between demand and supply in the future. One of the solutions is Demand Side Management (DSM) where mobilizing flexibility in demand is the main objective. This paper summarizes two research projects on the economical and

  5. User centric design of smart grid : a social ande economical approach

    NARCIS (Netherlands)

    Kobus, C.B.A.; Jonge, de B.; Knigge, J.D.; Slootweg, J.G.

    2011-01-01

    The energy transition poses challenges for maintaining the energy balance between demand and supply in the future. One of the solutions is Demand Side Management (DSM) where mobilizing flexibility in demand is the main objective. This paper summarizes two research projects on the economical and

  6. Examining the impacts of oil price changes on economic indicators: A panel approach

    Science.gov (United States)

    Lim, Kah Boon; Sek, Siok Kun

    2017-04-01

    The impact of oil price on global economy is evident from many studies and research findings. In this study, we extend the research on examining the impact of oil price changes on economic indicators in terms of economic growth and inflation by comparing different groups of economies (high income versus low income countries and oil importing versus oil exporting countries). Our main objective is to reveal if such impact varies across country income level/ development and oil dependency. In addition, we also seek to compare the impacts of oil price relative to the other factors indicators (money supply, foreign direct investment, exchange rate, government expenditure, inflation and gross domestic product) on economy. For the purpose of this study, the co-integration regression (DOLS and FMOLS) techniques are applied to the panel dataset of four groups of economies which contain 10 countries in each panel dataset. The analysis results show that oil price is not the main determinant although it can have a significant impact on inflation and economic growth across all groups of economies. The three main determinants of economic growth are exchange rate, aggregate demand and government expenditure while the determinants of inflation are aggregate supply and exchange rate. Furthermore, our result also concludes that oil price has a positive impact in oil exporting economies but it shows a negative impact in oil importing economies due to the oil dependency factor.

  7. Optimising the management of complex dynamic ecosystems. An ecological-economic modelling approach

    NARCIS (Netherlands)

    Hein, L.G.

    2005-01-01

    Keywords: ecological-economic modelling; ecosystem services; resource use; efficient; sustainability; wetlands, rangelands.

  8. Efficiency improvement for a sustainable agriculture : the integration of agronomic and farm economics approaches

    OpenAIRE

    Koeijer, de, T.J.

    2002-01-01

    Keywords: Sustainable farming systems, Agronomic efficiency, Economic efficiency, Environmental efficiency, Sustainability index, Interdisciplinary analysis.

    The objective of the research described in this thesis was to determine what role improved agronomic efficiency can play in the transition towards more sustainable production systems. Agronomic efficiency measures the technical performance. If it could be improved, environmental damage could be reduced while, at the sam...

  9. A THEORETICAL APPROACH OF THE CONCEPT OF SOCIAL CAPITAL IN SUPPORTING ECONOMIC PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Boldea Monica

    2012-07-01

    Full Text Available Any activity requires the presence of labor resources. If centuries ago the concept was that their presence was enough, now it takes a lot more. Moreover, since Aristotle the issue was taking into consideration all aspects of the community life that can lead to a "better life". In the current conditions we may consider resources in the broader context of the human factor and of the relations established within a society. Thus social capital was conceptualized. As opportunities of economic growth - based purely on the quantitative aspects of the determinants – were limited, the need occurred to reconsider the qualitative and structural components. Social capital considers a number of the integrative components of social life. These refer to the relations established at family level up to the level of societal institutions. It is necessary that these relationships be well established, and for the proper performance it is necessary that aspects of education and health should be properly valued and assessed. This helps setting up strong institutions. Developed countries have the ability to create a proper environment for the manifestations of social capital; in these countries one can observe the growing importance of formal and more impersonal relations. But this just reinforces the occurrence and development of economic activities based on efficiency criteria leading to the countries’ economic development. The interpretations of economic development issues have undergone changes in recent decades. If previously it was considered that the essential difference between rich and poor countries is reflected in the amount of physical capital per person, later on the concept of capital has been expanded to include as well human capital, the lack of which was considered a serious obstacle to development, particularly in the case of poor countries. And given the fact that the transactions within an economic system take place in an

  10. A Multidisciplinary, Science-Based Approach to the Economics of Climate Change

    Science.gov (United States)

    Carlin, Alan

    2011-01-01

    Economic analyses of environmental mitigation and other interdisciplinary public policy issues can be much more useful if they critically examine what other disciplines have to say, insist on using the most relevant observational data and the scientific method, and examine lower cost alternatives to the change proposed. These general principles are illustrated by applying them to the case of climate change mitigation, one of the most interdisciplinary of public policy issues. The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO2 emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO2 emissions reductions on atmospheric CO2 appear to be short rather than long lasting.The costs of CO2 emissions reductions are very much higher than usually estimated because of technological and implementation problems recently identified.Geoengineering such as solar radiation management is a controversial alternative to CO2 emissions reductions that offers opportunities to greatly decrease these large costs, change global temperatures with far greater assurance of success, and eliminate the possibility of low probability, high consequence risks of rising temperatures, but has been largely ignored by economists.CO2 emissions reductions are economically unattractive since the very modest benefits remaining after the corrections for the above effects are quite unlikely to economically justify the much higher costs unless much lower cost geoengineering is used.The risk of catastrophic anthropogenic global warming appears to be so low that it is not currently worth doing anything to try to control it, including geoengineering. PMID:21695026

  11. Children are costly, but raising them may pay: The economic approach to fertility

    Directory of Open Access Journals (Sweden)

    Martin Werding

    2014-01-01

    Full Text Available Objective: This article provides a non-technical introduction to analyses of fertility which are based on a rational-choice paradigm and which acknowledge that raising children may have a strong impact on the well-being of parents that can be described in terms of costs and benefits. It surveys different types of economic fertility models which can be used to address a variety of research questions, and it also discusses some basic strengths and weaknesses of applying economic analyses in this particular field. Results: Starting from a seminal contribution by Becker (1960 which may have been of little use for applied research or for interdisciplinary work, the economic theory of fertility has unfolded a differentiated research programme with indispensable contributions to the broader field of fertility research. Important features are the inclusion of (i different bargaining positions and differing incentives of partners interacting in fertility choices; (ii simultaneous decisions regarding labour force participation (as well as education and fertility, and the role played by employers, labour market institutions, and other public interventions; (iii the idea that children (or their "human capital" are investment goods with various kinds of returns that may be dispersed over an extremely long period of time, are subject to enormous uncertainties, and are strongly influenced by the social context and, again, by public policies. Conclusions: Economic aspects and elements of economic models should be included in any large-scale attempt at understanding fertility behaviour through interdisciplinary research. Improvements in the data infrastructure, which are only partly underway thus far, would be an important pre-requisite.

  12. Supply-side approaches to the economic valuation of coastal and marine habitat in the Red Sea

    KAUST Repository

    Hoagland, P.

    2013-07-01

    The degradation of natural fish habitat in the ocean implies lost economic benefits. These value losses often are not measured or anticipated fully, and therefore they are mainly ignored in decisions to develop the coast for industrial or residential purposes. In such circumstances, the ocean habitat and its associated ecosystem are treated as if they are worthless. Measures of actual or potential economic values generated by fisheries in commercial markets can be used to assess a conservative (lower-bound) value of ocean habitat. With this information, one can begin to compare the values of coastal developments to the values of foregone ocean habitat in order to help understand whether development would be justified economically. In this paper, we focus on the economic value associated with the harvesting of commercial fish stocks as a relevant case for the Saudi Arabian portion of the Red Sea. We describe first the conceptual basis behind supply-side approaches to economic valuation. Next we review the literature on the use of these methods for valuing ocean habitat. We provide an example based on recent research assessing the bioeconomic status of the traditional fisheries of the Red Sea in the Kingdom of Saudi Arabia (KSA). We estimate the economic value of ecosystem services provided by the KSA Red Sea coral reefs, finding that annual per-unit values supporting the traditional fisheries only are on the order of 7000/km2. Finally, we develop some recommendations for refining future applications of these methods to the Red Sea environment and for further research. © 2013 .

  13. An Integrated Approach to Explore the Relationship Among Economic, Construction Land Use, and Ecology Subsystems in Zhejiang Province, China

    Directory of Open Access Journals (Sweden)

    Chuyu Xia

    2016-05-01

    Full Text Available Zhejiang Province, China is experiencing rapid urbanization, facing the challenge of coupling socioeconomic development and ecological conservation. This paper establishes a comprehensive index system to assess coordinating development of economic, construction land use (CLU, and ecology subsystems. A Granger test and a coupling coordination model were applied to explore the causal relationship and the coordinated development state among the three subsystems from 2000 to 2012. The results showed that: (1 changes in the integrated value of the economic subsystem were the Granger cause of changes in the ecology and CLU subsystems, and the changes in the integrated values of ecology and CLU was each other’s Granger cause; (2 the coupling coordination relationship of the integrated value for economic–CLU–ecology was constrained by the relationship between the economic and the CLU subsystems from 2000 to 2004, and that between the ecology and the economic subsystems was the impediment of the sustainable development of economic–CLU–ecology from 2004 to 2012. This research helps to identify approach to sustainable development through analyzing synergistic effects, interdependencies, and trade-offs among the integrated economic–CLU–ecology values, and to make significant contribution to urban planning policies in rapid urbanization region.

  14. Economic policy uncertainty, equity premium and dependence between their quantiles: Evidence from quantile-on-quantile approach

    Science.gov (United States)

    Raza, Syed Ali; Zaighum, Isma; Shah, Nida

    2018-02-01

    This paper examines the relationship between economic policy uncertainty and equity premium in G7 countries over a period of the monthly data from January 1989 to December 2015 using a novel technique namely QQ regression proposed by Sim and Zhou (2015). Based on QQ approach, we estimate how the quantiles of the economic policy uncertainty affect the quantiles of the equity premium. Thus, it provides a comprehensive insight into the overall dependence structure between the equity premium and economic policy uncertainty as compared to traditional techniques like OLS or quantile regression. Overall, our empirical evidence suggests the existence of a negative association between equity premium and EPU predominately in all G7 countries, especially in the extreme low and extreme high tails. However, differences exist among countries and across different quantiles of EPU and the equity premium within each country. The existence of this heterogeneity among countries is due to the differences in terms of dependency on economic policy, other stock markets, and the linkages with other country's equity market.

  15. Yerel Ekonomik Kalkınma Yaklaşımı ve Uluslararası Organizasyonlar(Local Economic Development Approach and International Organizations

    Directory of Open Access Journals (Sweden)

    Murat ÇETİN

    2007-01-01

    Full Text Available Belief in traditional economic development practices has started to be breached as a result of the accelaration of globalization tendency since 1980s, thus making local economic development approach subject matter. In this study, after having this approach been dealt with, local economic development experiences carried out by such international organizations as the International Labor Office, the European Union and the Organization for Economic Co-operation and Development are comparatively examined. The common features of these practices are their appreciation of local initiatives, participation and cooperation, and having an integrated, decentralized and innovative structure.

  16. AN ANALYTICAL FRAMEWORK FOR ASSESSING RELIABLE NUCLEAR FUEL SERVICE APPROACHES: ECONOMIC AND NON-PROLIFERATION MERITS OF NUCLEAR FUEL LEASING

    International Nuclear Information System (INIS)

    Kreyling, Sean J.; Brothers, Alan J.; Short, Steven M.; Phillips, Jon R.; Weimar, Mark R.

    2010-01-01

    The goal of international nuclear policy since the dawn of nuclear power has been the peaceful expansion of nuclear energy while controlling the spread of enrichment and reprocessing technology. Numerous initiatives undertaken in the intervening decades to develop international agreements on providing nuclear fuel supply assurances, or reliable nuclear fuel services (RNFS) attempted to control the spread of sensitive nuclear materials and technology. In order to inform the international debate and the development of government policy, PNNL has been developing an analytical framework to holistically evaluate the economics and non-proliferation merits of alternative approaches to managing the nuclear fuel cycle (i.e., cradle-to-grave). This paper provides an overview of the analytical framework and discusses preliminary results of an economic assessment of one RNFS approach: full-service nuclear fuel leasing. The specific focus of this paper is the metrics under development to systematically evaluate the non-proliferation merits of fuel-cycle management alternatives. Also discussed is the utility of an integrated assessment of the economics and non-proliferation merits of nuclear fuel leasing.

  17. ACE up the sleeve - are vascular patients medically optimized?

    LENUS (Irish Health Repository)

    Coveney, A P

    2011-03-01

    To examine the current medical management of arteriopathic patients attending a vascular surgical service at a university teaching hospital over a 6-month period. The prescribing of antiplatelets, statins, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers and beta-blockers was specifically examined. Vascular patients are often under the care of multiple specialties, and therefore the influence of different medical specialties on the patients\\' medical management was also examined.

  18. APPROACHES TO EUROPEAN UNION MILITARY COLLABORATION IN THE CURRENT ECONOMIC AUSTERITY ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Maria CONSTANTINESCU

    2012-01-01

    Full Text Available The effects of the economic crisis on European countries has led to serious cuts of the defense budgets and a perceived reduction in the EU’s ability to provide capabilities required by other allies, especially the US. Cooperation, in the form of pooling and sharing may not be an easy and “ready to use” solution to Europe’s defense issues generated by the budget austerity and economic downturn, but it may provide ways to lessen the defense cuts impact on the military capabilities. Nonetheless, the success of the initiative is strongly related to the degree of political and military commitment of the EU countries to put into practice the concept.

  19. Alternative approaches to pollution control and waste management: Regulatory and economic instruments

    International Nuclear Information System (INIS)

    Bernstein, J.D.

    1993-01-01

    The purpose of the paper is to present an overview of the most common strategies and policy instruments (that is, regulatory and economic) used in developed and developing countries to achieve pollution control and waste management objectives. Although this topic has been at the center of theoretical controversy both within and outside the World Bank, the paper is not intended to contribute to this debate. Rather, its purpose is to explore how regulatory and economic instruments are used to control air and water pollution, protect ground water, and manage solid and hazardous wastes. The paper is directed to policy makers at the national, state, and local levels of government, as well as to other parties responsible for pollution control and waste management programs

  20. CAUSAL RELATIONSHIP BETWEEN FOSSIL FUEL CONSUMPTION AND ECONOMIC GROWTH IN JAPAN: A MULTIVARIATE APPROACH

    Directory of Open Access Journals (Sweden)

    Hazuki Ishida

    2013-01-01

    Full Text Available This paper explores whether Japanese economy can continue to grow without extensive dependence on fossil fuels. The paper conducts time series analysis using a multivariate model of fossil fuels, non-fossil energy, labor, stock and GDP to investigate the relationship between fossil fuel consumption and economic growth in Japan. The results of cointegration tests indicate long-run relationships among the variables. Using a vector error-correction model, the study reveals bidirectional causality between fossil fuels and GDP. The results also show that there is no causal relationship between non-fossil energy and GDP. The results of cointegration analysis, Granger causality tests, and variance decomposition analysis imply that non-fossil energy may not necessarily be able to play the role of fossil fuels. Japan cannot seem to realize both continuous economic growth and the departure from dependence on fossil fuels. Hence, growth-oriented macroeconomic policies should be re-examined.

  1. Insurance penetration and economic growth in Africa: Dynamic effects analysis using Bayesian TVP-VAR approach

    Directory of Open Access Journals (Sweden)

    D.O. Olayungbo

    2016-12-01

    Full Text Available This paper examines the dynamic interactions between insurance and economic growth in eight African countries for the period of 1970–2013. Insurance demand is measured by insurance penetration which accounts for income differences across the sample countries. A Bayesian Time Varying Parameter Vector Auto regression (TVP-VAR model with stochastic volatility is used to analyze the short run and the long run among the variables of interest. Using insurance penetration as a measure of insurance to economic growth, we find positive relationship for Egypt, while short-run negative and long-run positive effects are found for Kenya, Mauritius, and South Africa. On the contrary, negative effects are found for Algeria, Nigeria, Tunisia, and Zimbabwe. Implementation of sound financial reforms and wide insurance coverage are proposed recommendations for insurance development in the selected African countries.

  2. Climate change economics on a small island: new approaches for Tobago

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, Murray [University of Oxford (United Kingdom); Birch, Tom

    2011-01-15

    For small islands like Tobago — that depend heavily on tourism driven by their natural 'beauty' — climate change poses a double-edged threat on supply and demand. Rising sea levels, increasing temperatures and more frequent and intense storms will damage the island's natural assets, such as coral reefs and beaches. This could have a heavy impact on tourism, which will also be affected by climate policy in 'source' countries. But what exactly will that impact be? How much will it cost? And what can be done about it? Traditional economic analysis is ill-equipped to answer these questions because it offers static and highly uncertain models and assessments of damage and loss, rather than flexible response options that consider system dynamics. We urgently need to use and expand new forms of economic analysis to better support the difficult decisions that Caribbean policymakers face as a result of climate change.

  3. A FUTURE APPROACHES, SOCIAL ORGANIZATION AND THEIR ECONOMIC CONSEQUENCES OF THE INFORMATIONAL SOCIETY – KNOWLEDGE SOCIETY

    Directory of Open Access Journals (Sweden)

    NICULAE DAVIDESCU

    2011-04-01

    Full Text Available The paper is the result of scientific study under doctoral thesis “Information Society and its Economic Effects” and contains seven sections: -section 1: “Globalization, Development and Information Society”; -section 2: “The Impact of the “Digital Divide” and “Digital Inequality” Phenomena” ; -section 3: “Information Society –Knowledge Society, Definition, Objectives and Strategies” ; -section 4: “Social Structures and New Life Patterns in Information Society” ; -section 5: “Virtual Organizations, Activities and Businesses” ; -section 6: “Strategies, Programmes and Courses of the Information Society Approach” ; -section 7: “The Economic Effects Foreseeable through the Implementation of Information Society–Knowledge Society”.

  4. Nicotine reduction as an increase in the unit price of cigarettes: A behavioral economics approach

    OpenAIRE

    Smith, Tracy T.; Sved, Alan F.; Hatsukami, Dorothy K.; Donny, Eric C.

    2014-01-01

    Urgent action is needed to reduce the harm caused by smoking. Product standards that reduce the addictiveness of cigarettes are now possible both in the U.S. and in countries party to the Framework Convention on Tobacco Control. Specifically, standards that required substantially reduced nicotine content in cigarettes could enable cessation in smokers and prevent future smoking among current non-smokers. Behavioral economics uses principles from the field of microeconomics to characterize how...

  5. National approach to economic performance indicators for nuclear power plants: USA

    International Nuclear Information System (INIS)

    2006-01-01

    The structure of the US electric power industry comprises a combination of traditional electric utilities and less traditional electricity producing companies. The electric utilities include investor owned, publicly owned, federal and cooperative firms. Approximately three quarters of the electricity generated by utilities is generated by investor owned companies. These utilities are, for the most part, franchised monopolies that have an obligation to provide electricity to all customers within a service area. Most provide for the generation, transmission and distribution of electricity, although the distinctions between these services are breaking down as the electricity industry becomes more deregulated. The shares are publicly traded and their areas of business operation are expanding into new ones, sometimes unrelated to the provision of electricity or even energy. Under deregulation and open market pricing of electricity, the business and financial success of operating nuclear plants must be considered to a much greater extent along with the successful achievement of safety and reliability objectives. In developing strategic and operational goals, nuclear plant managers are required to embrace clear and measurable business objectives and goals that not only assure the achievement of safety and reliability but, in addition, eliminate unnecessary costs and identify investment opportunities. These goals must balance operating and safety risk while optimizing plant revenues and earnings and ultimately ensure the profitability of electricity generating facilities. In doing so, it is essential that plant managers articulate goal achievement through the application of effective, measurable, economic performance indicators. Individual nuclear plants will sell their output competing on electricity price, ultimately to ensure the safe, reliable and economic dispatch of their generation either onto open spot markets or by competitive bidding for bilateral contracts. In

  6. Minimum Wages and Workers' "Motivation": An approach using an economic experiment (Japanese)

    OpenAIRE

    MORI Tomoharu

    2013-01-01

    This paper investigates the effect of minimum wages on workers' effort levels (motivation) using an economic experiment conducted in a laboratory. Under the gift-exchange theory, if firms pay higher wages, workers exert more effort. Vice versa, if firms pay lower wages, workers exert less effort. Minimum wages affect the judgment as to whether the wages being paid are high or low. In general, wages near the minimum appear unattractive. However, it is possible that the same level of wage will ...

  7. Assessing dark tourism as a sustainable economic activity for emerging destinations using a multi criteria approach

    OpenAIRE

    Seraphin, Hugues

    2017-01-01

    The tourism industry only started to be considered as an economic activity in 1911 (Scutariu, 2009). The reasons why people have been travelling and are still travelling to certain places are for sport and leisure; culture; Visiting Friends and Relatives; business; health; religion; education (Barrow, 2008). These different reasons contribute to the branding of some destinations by visitors and potential visitors. On that basis, it is legitimate to wonder whether being branded as a dark touri...

  8. Approaches to Refining Estimates of Global Burden and Economics of Dengue

    Science.gov (United States)

    Shepard, Donald S.; Undurraga, Eduardo A.; Betancourt-Cravioto, Miguel; Guzmán, María G.; Halstead, Scott B.; Harris, Eva; Mudin, Rose Nani; Murray, Kristy O.; Tapia-Conyer, Roberto; Gubler, Duane J.

    2014-01-01

    Dengue presents a formidable and growing global economic and disease burden, with around half the world's population estimated to be at risk of infection. There is wide variation and substantial uncertainty in current estimates of dengue disease burden and, consequently, on economic burden estimates. Dengue disease varies across time, geography and persons affected. Variations in the transmission of four different viruses and interactions among vector density and host's immune status, age, pre-existing medical conditions, all contribute to the disease's complexity. This systematic review aims to identify and examine estimates of dengue disease burden and costs, discuss major sources of uncertainty, and suggest next steps to improve estimates. Economic analysis of dengue is mainly concerned with costs of illness, particularly in estimating total episodes of symptomatic dengue. However, national dengue disease reporting systems show a great diversity in design and implementation, hindering accurate global estimates of dengue episodes and country comparisons. A combination of immediate, short-, and long-term strategies could substantially improve estimates of disease and, consequently, of economic burden of dengue. Suggestions for immediate implementation include refining analysis of currently available data to adjust reported episodes and expanding data collection in empirical studies, such as documenting the number of ambulatory visits before and after hospitalization and including breakdowns by age. Short-term recommendations include merging multiple data sources, such as cohort and surveillance data to evaluate the accuracy of reporting rates (by health sector, treatment, severity, etc.), and using covariates to extrapolate dengue incidence to locations with no or limited reporting. Long-term efforts aim at strengthening capacity to document dengue transmission using serological methods to systematically analyze and relate to epidemiologic data. As promising tools

  9. Adverse childhood experiences (ACE) and adult attachment interview (AAI) in a non-clinical population.

    Science.gov (United States)

    Thomson, Paula; Jaque, S Victoria

    2017-08-01

    Adverse childhood experiences (ACE) tend to be interrelated rather than independently occurring. There is a graded effect associated with ACE exposure and pathology, with an increase when ACE exposure is four or more. This study examined a sample of active individuals (n=129) to determine distribution patterns and relationships between ACEs, attachment classification, unresolved mourning (U), and disclosure difficulty. The results of this study demonstrated a strong relationship between increased ACEs and greater unresolved mourning. Specifically, the group differences for individuals who experienced no ACE (n=42, 33%), those with 1-3 ACEs (n=48, 37.8%), and those with ≥4 ACEs (n=37, 29.1%) revealed a pattern in which increased group ACE exposure was associated with greater lack of resolution for past trauma/loss experiences, more adult traumatic events, and more difficulty disclosing past trauma. Despite ≥4 ACEs, 51.4% of highly exposed individuals were classified as secure in the Adult Attachment Interview. Resilience in this group may be related to a combination of attachment security, college education, and engagement in meaningful activities. Likewise, adversity may actually encourage the cultivation of more social support, goal efficacy, and planning behaviors; factors that augment resilience to adversity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy.

    Science.gov (United States)

    Rahimi, Zohreh

    2012-10-01

    Angiotensin converting enzyme (ACE) gene encodes ACE, a key component of renin angiotensin system (RAS), plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II. Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype. In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.

  11. Impact of the Sugar Import Reduction on Iran Economic Value Added (Input- Output Approach

    Directory of Open Access Journals (Sweden)

    Fateme Hayatgheibi

    2014-06-01

    Full Text Available The present study aimed at understanding interactions and linkages between the sugar sector with other economic sectors, and the influence of sugar import reduction on the economic value added. To achieve the purpose, the Input-Output table of Iran for the year 2006, Leontief inverse matrix and hypothetical extraction method were used. Based on the results, sugar industry has the most forward linkages with “Manufacture of food products and beverages,…”, “husbandry, aviculture,…”, “cultivation, horticulture”, “bakery products” and “restaurants”. This sector has also strong backward linkages with “cultivation, horticulture”, “chemicals and chemical products”, “other services”, “transport and telecommunication” and “financial services, insurance and bank”. Furthermore, either one unit increase in the final demand of sugar or one unit decrease in the sugar import increases the output of whole economic, agricultural and fishing, industry and mining, and services sectors by 2.3060, 0.6019, 1.4331, and 0.2710 unit, respectively. The increasing coefficients of the value added for the above sectors are 0.4308, 0.3700, and 0.1992 unit, respectively.

  12. Addressing tuberculosis patients' medical and socio-economic needs: a comprehensive programmatic approach.

    Science.gov (United States)

    Contreras, Carmen C; Millones, Ana K; Santa Cruz, Janeth; Aguilar, Margot; Clendenes, Martin; Toranzo, Miguel; Llaro, Karim; Lecca, Leonid; Becerra, Mercedes C; Yuen, Courtney M

    2017-04-01

    For a cohort of patients with tuberculosis in Carabayllo, Peru, we describe the prevalence of medical comorbidities and socio-economic needs, the efforts required by a comprehensive support programme ('TB Cero') to address them and the success of this programme in linking patients to care. Patients diagnosed with tuberculosis in Carabayllo underwent evaluations for HIV, diabetes, mental health and unmet basic needs. For patients initiating treatment during 14 September, 2015-15 May, 2016, we abstracted data from evaluation forms and a support request system. We calculated the prevalence of medical comorbidities and the need for socio-economic support at the time of tuberculosis diagnosis, as well as the proportion of patients successfully linked to care or support. Of 192 patients, 83 (43%) had at least one medical comorbidity other than tuberculosis. These included eight (4%) patients with HIV, 12 (6%) with diabetes and 62 (32%) deemed at risk for a mental health condition. Of patients who required follow-up for a comorbidity, 100% initiated antiretroviral therapy, 71% attended endocrinology consultations and 66% attended psychology consultations. Of 126 (65%) patients who completed the socio-economic evaluation, 58 (46%) reported already receiving food baskets from the municipality, and 79 (63%) were given additional support, most commonly food vouchers and assistance in accessing health care. Carabayllo tuberculosis patients face many challenges in addition to tuberculosis. A collaborative, comprehensive treatment support programme can achieve high rates of linkage to care for these needs. © 2017 John Wiley & Sons Ltd.

  13. A hydrologic-economic modeling approach for analysis of urban water supply dynamics in Chennai, India

    Science.gov (United States)

    Srinivasan, Veena; Gorelick, Steven M.; Goulder, Lawrence

    2010-07-01

    In this paper, we discuss a challenging water resources problem in a developing world city, Chennai, India. The goal is to reconstruct past system behavior and diagnose the causes of a major water crisis. In order to do this, we develop a hydrologic-engineering-economic model to address the complexity of urban water supply arising from consumers' dependence on multiple interconnected sources of water. We integrate different components of the urban water system: water flowing into the reservoir system; diversion and distribution by the public water utility; groundwater flow in the aquifer beneath the city; supply, demand, and prices in the informal tanker-truck-based water market; and consumer behavior. Both the economic and physical impacts of consumers' dependence on multiple sources of water are quantified. The model is calibrated over the period 2002-2006 using a range of hydrologic and socio-economic data. The model's results highlight the inadequacy of the reservoir system and the buffering role played by the urban aquifer and consumers' coping investments during multiyear droughts.

  14. An approach for evaluating utility-financed energy conservation programs. The economic welfare model

    Energy Technology Data Exchange (ETDEWEB)

    Costello, K W; Galen, P S

    1985-09-01

    The main objective of this paper is to illustrate how the economic welfare model may be used to measure the economic efficiency effects of utility-financed energy conservation programs. The economic welfare model is the theoretical structure that was used in this paper to develop a cost/benefit test. This test defines the net benefit of a conservation program as the change in the sum of consumer and producer surplus. The authors advocate the operation of the proposed cost/benefit model as a screening tool to eliminate from more detailed review those programs where the expected net benefits are less than zero. The paper presents estimates of the net benefit derived from different specified cost/benefit models for four illustrative pilot programs. These models are representative of those which have been applied or are under review by utilities and public utility commissions. From the numerical results, it is shown that net benefit is greatly affected by the assumptions made about the nature of welfare gains to program participants. The main conclusion that emerges from the numerical results is that the selection of a cost/benefit model is a crucial element in evaluating utility-financed energy conservation programs. The paper also briefly addresses some of the major unresolved issues in utility-financed energy conservation programs. 2 figs., 3 tabs., 10 refs. (A.V.)

  15. Modern approaches to quintessence of public accounting of enterprise in context of economical safety providing

    Directory of Open Access Journals (Sweden)

    L.V. Gnilitskaya

    2016-07-01

    Full Text Available Discrepancy of possibilities of modern accounting to the demands of economical safety directed for the satisfaction of informational needs of various groups of users of accounting in order they could make grounded and timely management decisions while providing stable and steady functioning both an enterprise and a region where this enterprise runs and also a state as a whole, has caused the necessity of searching for other concepts and the models of accounting information formation. The research proves that the most advantages for economical safety providing belong to the concept of cost accounting. The use of this concept will allow to identify the information necessary for the sides interested in it; to model external corporation accounting including field peculiarities of an enterprise; to disclose the information concerning not only to internal parameters but also to external environment where the enterprise functions; to assess the risks of businesses and show their influence in corresponding forms of accounting. The adaptation of the concept of cost accounting into the practice of home enterprises (if the informational needs of economical safety are provided will require definite changes in the structure and contents of accounting information, on one hand, and the improvement (view, shift of the principles of preparation of accounting as the accounting base, on the other hand.

  16. Economic efficiency of e-learning in higher education: An industrial approach

    Directory of Open Access Journals (Sweden)

    Jordi Vilaseca

    2008-07-01

    Full Text Available Little work has been yet done to analyse if e-learning is an efficiency way in economic terms to produce higher education, especially because there are not available data in official statistics. Despite of these important constrains, this paper aims to contribute to the study of economic efficiency of e-learning through the analysis of a sample of e-learning universities during a period of time (1997-2002. We have wanted to obtain some empirical evidence to understand if e-learning is a feasible model of providing education for universities and which are the variables that allow for feasibility attainment. The main findings are: 1 that the rise of the number of students enrolled is consistent with increasing labour productivity rates; 2 that cost labour savings are explained by the improvement of universities’ economic efficiency (or total factor productivity; and 3 that improvement of total factor productivity in e-learning production is due to the attainment of scale economies, but also to two organisational innovations: outsourcing processes that leads to the increase of variable costs consistent with decreasing marginal costs, and the sharing of assets’ control and use that allow for a rise in assets rotation.

  17. The ACE2 gene: its potential as a functional candidate for cardiovascular disease.

    Science.gov (United States)

    Burrell, Louise M; Harrap, Stephen B; Velkoska, Elena; Patel, Sheila K

    2013-01-01

    The RAS (renin-angiotensin system) plays an important role in the pathophysiology of CVD (cardiovascular disease), and RAS blockade is an important therapeutic strategy in the management of CVD. A new counterbalancing arm of the RAS is now known to exist in which ACE (angiotensin-converting enzyme) 2 degrades Ang (angiotensin) II, the main effector of the classic RAS, and generates Ang-(1-7). Altered ACE2 expression is associated with cardiac and vascular disease in experimental models of CVD, and ACE2 is increased in failing human hearts and atherosclerotic vessels. In man, circulating ACE2 activity increases with coronary heart disease, as well as heart failure, and a large proportion of the variation in plasma ACE2 levels has been attributed to hereditary factors. The ACE2 gene maps to chromosome Xp22 and this paper reviews the evidence associating ACE2 gene variation with CVD and considers clues to potential functional ACE2 variants that may alter gene expression or transcriptional activity. Studies to date have investigated ACE2 gene associations in hypertension, left ventricular hypertrophy and coronary artery disease, but the results have been inconsistent. The discrepancies may reflect the sample size of the studies, the gender or ethnicity of subjects, the cardiovascular phenotype or the ACE2 SNP investigated. The frequent observation of apparent sex-dependence might be of special importance, if confirmed. As yet, there are no studies to concurrently assess ACE2 gene polymorphisms and circulating ACE2 activity. Large-scale carefully conducted clinical studies are urgently needed to clarify more precisely the potential role of ACE2 in the CVD continuum.

  18. Assertion checking environment (ACE) for formal verification of C programs

    International Nuclear Information System (INIS)

    Sharma, Babita; Dhodapkar, S.D.; Ramesh, S.

    2003-01-01

    In this paper we describe an Assertion Checking Environment (ACE) for compositional verification of programs, which are written in an industrially sponsored safe subset of C programming language called MISRA C [Guidelines for the Use of the C Language in Vehicle Based Software, 1998]. The theory is based on Hoare logic [Commun. ACM 12 (1969) 576] and the C programs are verified using static assertion checking technique. First the functional specifications of the program, captured in the form of pre- and post-conditions for each C function, are derived from the specifications. These pre- and post-conditions are then introduced as assertions (also called annotations or formal comments) in the program code. The assertions are then proved formally using ACE and theorem proving tool called Stanford Temporal Prover [The Stanford Temporal Prover User's Manual, 1998]. ACE has been developed by us and consists mainly of a translator c2spl, a GUI and some utility programs. The technique and tools developed are targeted towards verification of real-time embedded software

  19. The economic viability of value-based food chain for dairy farms in mountain regions: an econometric analysis approach

    Directory of Open Access Journals (Sweden)

    Jernej Prišenk

    2016-07-01

    Full Text Available The attention of this paper is drawn to analyze the economic potential of involvement of farmers into the small-medium sized value-based food chain (VBFC. The survey represents a solid dana basis from which econometric modelling approach was further developed. Empirical results reveal the positive economic viability on a general level; this means more stable purchase price of raw milk for dairy farms, which are the part of value-based food chain. Results point at inelastic demand for milk and milk related products. Furthermore, there are some accompanying and underlying indirect social benefits, such as production of high-quality food products, more stable and constant demand for raw milk, steady payments and better social situation. The last one is especially important for the farms operating in less-favored mountain areas where the survey was actually conducted.

  20. Tokyo Tech–Hitotsubashi Interdisciplinary Conference : New Approaches to the Analysis of Large-Scale Business and Economic Data

    CERN Document Server

    Takayasu, Misako; Takayasu, Hideki; Econophysics Approaches to Large-Scale Business Data and Financial Crisis

    2010-01-01

    The new science of econophysics has arisen out of the information age. As large-scale economic data are being increasingly generated by industries and enterprises worldwide, researchers from fields such as physics, mathematics, and information sciences are becoming involved. The vast number of transactions taking place, both in the financial markets and in the retail sector, is usually studied by economists and management and now by econophysicists. Using cutting-edge tools of computational analysis while searching for regularities and “laws” such as those found in the natural sciences, econophysicists have come up with intriguing results. The ultimate aim is to establish fundamental data collection and analysis techniques that embrace the expertise of a variety of academic disciplines. This book comprises selected papers from the international conference on novel analytical approaches to economic data held in Tokyo in March 2009. The papers include detailed reports on the market behavior during the finan...

  1. THREADS TO BIODIVERSITY AND ECONOMIC APPROACHES TO DEVELOPMENT OF LAND USE AS ITS PROTECTION

    Directory of Open Access Journals (Sweden)

    L. G. Demydenko

    2017-02-01

    Full Text Available In the article the understanding of ecological and economic instruments for biodiversity conservation as a system of market, legal and regulatory, institutional arrangements and policies for sustainable development of land use. In terms of European integration, which is the basis of foreign policy identity Ukraine, acquires particular significance modernization of the state, forming an effective and efficient system of public administration (Public Administration, able to introduce systematic and consistent decisions, submission of all tasks of foreign and domestic policy achievement of the conditions and criteria membership in the European Union, particularly in the field of biodiversity conservation and land use management of protected areas, as its component. The signing of the Association Agreement between Ukraine, on one hand, and the European Union and its Member States, of the other part (the Agreement offers new opportunities and creates new standards in various areas of public life, including environmental protection. Sectoral cooperation in the field of environmental protection in the Agreement stipulated in Chapter 6, which is called "Environment" Chapter V «economic and sectoral cooperation." For Ukraine, the implementation of EU legislation in the field of the environment occurs within the eight sectors governed by 29 sources of law (Directives and Regulations of the EU in this area. Directive and Regulation establishes common rules and standards that need to be transposed (transferred to domestic law. These rules and standards are not the subject of discussion and be completely achieved, otherwise stipulated penalties. Unlike modern environmental legislation of Ukraine, which in many respects is a declarative sources of EU law determine the quantitative and qualitative results, which should reach every country within a specified period of time. The feature of EU Directives is that States must adapt their legislation to achieve the

  2. Modeling urban growth by the use of a multiobjective optimization approach: environmental and economic issues for the Yangtze watershed, China.

    Science.gov (United States)

    Zhang, Wenting; Wang, Haijun; Han, Fengxiang; Gao, Juan; Nguyen, Thuminh; Chen, Yarong; Huang, Bo; Zhan, F Benjamin; Zhou, Lequn; Hong, Song

    2014-11-01

    Urban growth is an unavoidable process caused by economic development and population growth. Traditional urban growth models represent the future urban growth pattern by repeating the historical urban growth regulations, which can lead to a lot of environmental problems. The Yangtze watershed is the largest and the most prosperous economic area in China, and it has been suffering from rapid urban growth from the 1970s. With the built-up area increasing from 23,238 to 31,054 km(2) during the period from 1980 to 2005, the watershed has suffered from serious nonpoint source (NPS) pollution problems, which have been mainly caused by the rapid urban growth. To protect the environment and at the same time maintain the economic development, a multiobjective optimization (MOP) is proposed to tradeoff the multiple objectives during the urban growth process of the Yangtze watershed. In particular, the four objectives of minimization of NPS pollution, maximization of GDP value, minimization of the spatial incompatibility between the land uses, and minimization of the cost of land-use change are considered by the MOP approach. Conventionally, a genetic algorithm (GA) is employed to search the Pareto solution set. In our MOP approach, a two-dimensional GA, rather than the traditional one-dimensional GA, is employed to assist with the search for the spatial optimization solution, where the land-use cells in the two-dimensional space act as genes in the GA. Furthermore, to confirm the superiority of the MOP approach over the traditional prediction approaches, a widely used urban growth prediction model, cellular automata (CA), is also carried out to allow a comparison with the Pareto solution of MOP. The results indicate that the MOP approach can make a tradeoff between the multiple objectives and can achieve an optimal urban growth pattern for Yangtze watershed, while the CA prediction model just represents the historical urban growth pattern as the future growth pattern

  3. Approaches to Aggregation and Decision Making-A Health Economics Approach: An ISPOR Special Task Force Report [5].

    Science.gov (United States)

    Phelps, Charles E; Lakdawalla, Darius N; Basu, Anirban; Drummond, Michael F; Towse, Adrian; Danzon, Patricia M

    2018-02-01

    The fifth section of our Special Task Force report identifies and discusses two aggregation issues: 1) aggregation of cost and benefit information across individuals to a population level for benefit plan decision making and 2) combining multiple elements of value into a single value metric for individuals. First, we argue that additional elements could be included in measures of value, but such elements have not generally been included in measures of quality-adjusted life-years. For example, we describe a recently developed extended cost-effectiveness analysis (ECEA) that provides a good example of how to use a broader concept of utility. ECEA adds two features-measures of financial risk protection and income distributional consequences. We then discuss a further option for expanding this approach-augmented CEA, which can introduce many value measures. Neither of these approaches, however, provide a comprehensive measure of value. To resolve this issue, we review a technique called multicriteria decision analysis that can provide a comprehensive measure of value. We then discuss budget-setting and prioritization using multicriteria decision analysis, issues not yet fully resolved. Next, we discuss deliberative processes, which represent another important approach for population- or plan-level decisions used by many health technology assessment bodies. These use quantitative information on CEA and other elements, but the group decisions are reached by a deliberative voting process. Finally, we briefly discuss the use of stated preference methods for developing "hedonic" value frameworks, and conclude with some recommendations in this area. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  4. An economic evaluation of introducing a skills mix approach to CT head reporting in clinical practice

    International Nuclear Information System (INIS)

    Lockwood, P.

    2016-01-01

    Background: Computed Tomography (CT) head examinations are a common diagnostic examination in National Health Service (NHS) acute hospital trusts. Current NHS England and Royal College of Radiologist (RCR) reports estimate the year on year increase of examinations to be 10%, with the designated workforce of radiologists disproportionate to the increase in demand of imaging reporting. Objective: To determine an economic evaluation of cost, risk and feasibility of introducing skills mix CT head reporting by radiographers. Design: Applying a PICO framework study to evaluate the patient workflow demand from retrospective audit data of CT head examination attendance (n = 7266) at an acute NHS district general hospital (DGH) to model an example workflow demand over 12 months. Reviewing potential outcome risk data (diagnostic thresholds), and feasibility (workforce capacity) of both interventions. The economic evaluation calculated hourly unit costs for comparison estimation of consultant radiologists and reporting radiographers using Netten et al.'s Ready Reckoner. Report unit costs were calculated utilising the Gishen's Ready Reckoner to estimate the uninterrupted time of reporting a non-complex CT report using RCR, Centre for Workforce Intelligence (CfWI) and Department of Health (DoH) estimates for both interventions. Conclusions: The economic evaluation of introducing a skills mix reporting service model to the benefit of service delivery with the NHS has shown a potential £299,359–£124,514 per annum cost saving using a generic acute DGH workload model. Research into recorded discrepancy/error audit data for potential detrimental risk to patient outcomes identified a paucity of evidence, and recommends further research is needed. - Highlights: • There was 5.2 million CT scans from April 2013 to March 2014 in the UK. • In 2015 the RCR estimated there were up to 3693 unreported CT scans. • Comparison of workforce, reference standards, unit costs

  5. Economic Value Approach to Industrial Water Demand Management, A Case Study of Chemical Plants

    Directory of Open Access Journals (Sweden)

    morteza tahami pour zarandi

    2017-03-01

    Full Text Available Limitations in water supply to meet the increasing demand have encouraged both planners and researchers to focus attention on water demand management, in which such economic tools as the water pricing system play a major role. A fundamental component of the pricing system is the estimation of the economic value of water, which reflects a firm’s maximum affordable water price or the ultimate elasticity of industrial water. The present study was conducted to estimate the economic value of water for basic chemical plants, excluding fertilizers and nitrogen compounds (code 2411, representing the four-digit ISIC industrial codes which account for about 14% of the total industrial water consumption. The econometric method of production function within the framework of panel data and the residual method were used. Data were collected from the Census of medium-sized businesses carried out by the Statistical Center of Iran over the period 1997–2013.  Results showed that one cubic meter of water allocated to the plants surveyed creates a value of 3,7071 Rials, which shows a large gap with the current purchase price of 5685 Rials. Moreover, it was found that the present water prices account for only about 1.3 percent of the total production cost of basic chemicals, excluding fertilizers and nitrogen compounds. It may, thus, be concluded that it is reasonable to increase the present water tariffs and discriminate among the various manufacturing codes by differences in tariffs in order to achieve water demand management goals. Finally, the information emerging from the study may be exploited to improve the revenues earned by water authorities or to carry out feasibility studies of industrial water development projects.

  6. Fossil fuel depletion and socio-economic scenarios: An integrated approach

    International Nuclear Information System (INIS)

    Capellán-Pérez, Iñigo; Mediavilla, Margarita; Castro, Carlos de; Carpintero, Óscar; Miguel, Luis Javier

    2014-01-01

    The progressive reduction of high-quality-easy-to-extract energy is a widely recognized and already ongoing process. Although depletion studies for individual fuels are relatively abundant, few of them offer a global perspective of all energy sources and their potential future developments, and even fewer include the demand of the socio-economic system. This paper presents an Economy-Energy-Environment model based on System Dynamics which integrates all those aspects: the physical restrictions (with peak estimations for oil, gas, coal and uranium), the techno-sustainable potential of renewable energy estimated by a novel top-down methodology, the socio-economic energy demands, the development of alternative technologies and the net CO 2 emissions. We confront our model with the basic assumptions of previous Global Environmental Assessment (GEA) studies. The results show that demand-driven evolution, as performed in the past, might be unfeasible: strong energy-supply scarcity is found in the next two decades, especially in the transportation sector before 2020. Electricity generation is unable to fulfill its demand in 2025–2040, and a large expansion of electric renewable energies move us close to their limits. In order to find achievable scenarios, we are obliged to set hypotheses which are hardly used in GEA scenarios, such as zero or negative economic growth. - Highlights: • The paper presents and describes a new Energy–Economy–Environment global model. • GEA scenario dynamics have the potential to lead us to energy resource scarcity in the next 2 decades. • Global forecasts of international agencies show inconsistency in energy constraints. • Renewable energies are only partially able to replace fossil fuels depletion. • Climate change still reaches dangerous dimensions

  7. Measuring energy rebound effect in the Chinese economy: An economic accounting approach

    International Nuclear Information System (INIS)

    Lin, Boqiang; Du, Kerui

    2015-01-01

    Estimating the magnitude of China's economy-wide rebound effect has attracted much attention in recent years. Most existing studies measure the rebound effect through the additional energy consumption from technological progress. However, in general technological progress is not equivalent to energy efficiency improvement. Consequently, their estimation may be misleading. To overcome the limitation, this paper develops an alternative approach for estimating energy rebound effect. Based on the proposed approach, China's economy-wide energy rebound effect is revisited. The empirical result shows that during the period 1981–2011 the rebound effects in China are between 30% and 40%, with an average value of 34.3%. - Highlights: • This paper develops an alternative approach for estimating energy rebound effect. • The proposed approach is based on the multilevel–hierarchical (M–H) IDA model. • The energy rebound effects in China are estimated between 30% and 40%

  8. An approach to the economics of two vegetable oil-based biofuels in Spain

    Energy Technology Data Exchange (ETDEWEB)

    Dorado, M.P.; Cruz, F.; Palomar, J.M. [Department of Mechanics and Mining, University of Jaen, EUP of Linares, C/. Alfonso X el Sabio 28, 23700 Linares (Jaen) (Spain); Lopez, F.J. [Department of Agricultural Engineering, University of Cordoba, ETSIAM, Avda. Menendez Pidal s/n, 14080 Cordoba (Spain)

    2006-07-15

    Biodiesel is a form of renewable energy that provides a less polluting fuel for diesel engines with minimal reduced engine performance as a result of a slight power loss and specific fuel consumption increase. To extend the use of biodiesel, the main concern is the economic viability of producing biodiesel. This study identified that the price of the feedstock was one of the most significant factors. Also, glycerol was found to be a valuable by-product that could reduce the final manufacturing costs of the process up to 6.5%, depending on the raw feedstock used. Biodiesel can only compete with diesel fuel prices. (author)

  9. Integrating socio-economical dimensions in the ICRP cost-benefit model (a theoretical approach)

    International Nuclear Information System (INIS)

    Lochard, Jacques.

    1981-09-01

    This report aims at analysing, from a methodological point of view, the main problems associated with the integration of socio-economical dimensions in the cost-benefit model recommended by the ICRP in its publication no. 26. After recalling the basic principles of cost-benefit analysis, the elements to be retained in the objective function characterizing the analysis, and the question of the social benefit definitions are discussed. The theory of social surplus with an illustration taken from the radiological protection field is presented [fr

  10. A supervisory control approach in economic MPC design for refrigeration systems

    DEFF Research Database (Denmark)

    Shafiei, Seyed Ehsan; Stoustrup, Jakob; Rasmussen, Henrik

    2013-01-01

    A model predictive control at the supervisory level is proposed for refrigeration systems using price and temperature predictions. The control objective is to minimize the overall energy cost within the prediction horizon. The method is mainly developed for demand-side management in the future...... to rearrange the problem to facilitate convex programming. A nonlinear continuous time model validated by real data is employed to simulate system operation. The results show a considerable economic saving as well as a trade-off between the saving level and design complexity....

  11. Integrated assessment of policy interventions for promoting sustainable irrigation in semi-arid environments: a hydro-economic modeling approach.

    Science.gov (United States)

    Blanco-Gutiérrez, Irene; Varela-Ortega, Consuelo; Purkey, David R

    2013-10-15

    Sustaining irrigated agriculture to meet food production needs while maintaining aquatic ecosystems is at the heart of many policy debates in various parts of the world, especially in arid and semi-arid areas. Researchers and practitioners are increasingly calling for integrated approaches, and policy-makers are progressively supporting the inclusion of ecological and social aspects in water management programs. This paper contributes to this policy debate by providing an integrated economic-hydrologic modeling framework that captures the socio-economic and environmental effects of various policy initiatives and climate variability. This modeling integration includes a risk-based economic optimization model and a hydrologic water management simulation model that have been specified for the Middle Guadiana basin, a vulnerable drought-prone agro-ecological area with highly regulated river systems in southwest Spain. Namely, two key water policy interventions were investigated: the implementation of minimum environmental flows (supported by the European Water Framework Directive, EU WFD), and a reduction in the legal amount of water delivered for irrigation (planned measure included in the new Guadiana River Basin Management Plan, GRBMP, still under discussion). Results indicate that current patterns of excessive water use for irrigation in the basin may put environmental flow demands at risk, jeopardizing the WFD's goal of restoring the 'good ecological status' of water bodies by 2015. Conflicts between environmental and agricultural water uses will be stressed during prolonged dry episodes, and particularly in summer low-flow periods, when there is an important increase of crop irrigation water requirements. Securing minimum stream flows would entail a substantial reduction in irrigation water use for rice cultivation, which might affect the profitability and economic viability of small rice-growing farms located upstream in the river. The new GRBMP could contribute

  12. RESEARCH: An Ecoregional Approach to the Economic Valuation of Land- and Water-Based Recreation in the United States

    Science.gov (United States)

    Bhat; Bergstrom; Teasley; Bowker; Cordell

    1998-01-01

    / This paper describes a framework for estimating the economic value of outdoor recreation across different ecoregions. Ten ecoregions in the continental United States were defined based on similarly functioning ecosystem characters. The individual travel cost method was employed to estimate recreation demand functions for activities such as motor boating and waterskiing, developed and primitive camping, coldwater fishing, sightseeing and pleasure driving, and big game hunting for each ecoregion. While our ecoregional approach differs conceptually from previous work, our results appear consistent with the previous travel cost method valuation studies.KEY WORDS: Recreation; Ecoregion; Travel cost method; Truncated Poisson model

  13. Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity

    DEFF Research Database (Denmark)

    Lee, Julie; Nordestgaard, Børge G; Dahl, Morten

    2009-01-01

    The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for risk of asthma, COPD, and COPD co-morbidity. In 9034 Danish adults, we determined whether individuals homozygous or heterozygous for the ACE D allele are at greater risk of asthma, COPD, or COPD co-morbidity compared...... with ACE II homozygous individuals. In the general population, serum ACE activity increased with the number of D alleles (Kruskal-Wallis ANOVA: II vs. ID, p....4-1.2). The results were similar upon adjustment for sex, age, smoking status, body mass index, total cholesterol, and ACE inhibitor/angiotensin II type 1 receptor blocker use. These data suggest that lifelong genetically elevated ACE activity is not a major risk factor for asthma or COPD, or for ischemic heart...

  14. Time-varying economic dominance in financial markets: A bistable dynamics approach

    Science.gov (United States)

    He, Xue-Zhong; Li, Kai; Wang, Chuncheng

    2018-05-01

    By developing a continuous-time heterogeneous agent financial market model of multi-assets traded by fundamental and momentum investors, we provide a potential mechanism for generating time-varying dominance between fundamental and non-fundamental in financial markets. We show that investment constraints lead to the coexistence of a locally stable fundamental steady state and a locally stable limit cycle around the fundamental, characterized by a Bautin bifurcation. This provides a mechanism for market prices to switch stochastically between the two persistent but very different market states, leading to the coexistence and time-varying dominance of seemingly controversial efficient market and price momentum over different time periods. The model also generates other financial market stylized facts, such as spillover effects in both momentum and volatility, market booms, crashes, and correlation reduction due to cross-sectional momentum trading. Empirical evidence based on the U.S. market supports the main findings. The mechanism developed in this paper can be used to characterize time-varying economic dominance in economics and finance in general.

  15. A REGIONAL APPROACH TO THE METROPOLITAN ECONOMIC GROWTH: EVIDENCE FROM THE EUROPEAN UNION

    Directory of Open Access Journals (Sweden)

    Florin Teodor Boldeanu

    2016-09-01

    Full Text Available The main goal of this study is to contribute to metropolitan economic growth literature by carrying out an analysis for 271 areas located in the EU between 2000 and 2013. For this objective the study uses several panel data estimation techniques, namely the GMM, System GMM and the QML estimation. To check the robustness of the results, the time period is divided in two (post and ante economic crisis and by splitting the sample of metropolitan regions in two components, the Western more developed regions and the Central and South-Eastern (the formal communist states, except for Cyprus areas. The results indicate that the industrial, construction and wholesale and retail trade sectors are positively linked with metropolitan growth. The agricultural, fishery and forestry sector is negatively influencing growth. The manufacturing and ITC sectors and migration are not statistically significant. Furthermore population density and size is more important than population growth and European enlargement did not have a substantial positive impact on metropolitan growth for the Central and South-Eastern regions.

  16. Economic Ergonomic Approach to Design an Optimal Manpower and Mechanization in Rice Production

    Science.gov (United States)

    Muanah; Syuaib, M. F.; Liyantono

    2018-05-01

    Productivity of manpower could be improved by considering the economic and ergonomic aspect. The ergonomic aspect (human factor) is required to design an optimal manpower, while in the economic aspect, the well being of manpower could be evaluated from the amount of received income based on their work capability. This research was conducted on February 2016 to January 2017 in Gapoktan Silih Asih rice field Cigombong, Bogor. This study aims to analyze the income of manpower based on current conditions, increasement of working hours and mechanization addition. The results showed that manpower income based on the current condition and ergonomic consideration was Rp 1,174,030/person.month, by increasing the working hours with ergonomic consideration the obtained income was Rp 1,766,204/person.month. the revenues were based on the existing work system even though the increasement of working hours have not provided optimal income due to low productivity. Therefore the results of analysis with the addition of selective mechanization, showed self-ownership machinery was more profitable the obtained income have more than the Bogor minimum wage standard of Rp 2,969,325/person.month.

  17. Different approaches to the Czech and Chinese university students in Business Economics: A teaching experience

    Directory of Open Access Journals (Sweden)

    Zuzana Wozniaková

    2016-03-01

    Full Text Available University internationalization in the field of education as well as in the field of science and research is one of the main priorities of VŠB – Technical University of Ostrava. VŠB – Technical University of Ostrava has several double degree agreements with foreign universities, mostly from Western Europe – e.g. Great Britain, Finland, but also with foreign universities outside Europe. In 2009 VŠB – Technical University of Ostrava signed a memorandum with Hubei University of Technology. This cooperation involves travelling of the Czech teachers to China and teaching several subjects at Hubei University of Technology as well as teaching 3rd year Chinese students at VŠB – Technical University of Ostrava (Czech Republic. This paper brings own teaching experience of the European lecturer who gave the lectures at the Chinese university for the Chinese students studying in English. Ishikawa diagram was used to determine the main causes of Chinese students’ failure in Business Economics. This paper brings modified methods of teaching Business Economics to be more suitable for Chinese students as well as critical review of Chinese students’ learning styles and characteristics observed by the author of the paper.

  18. Extension of the ACE solar panels is tested in SAEF-II

    Science.gov (United States)

    1997-01-01

    Extension of the solar panels is tested on the Advanced Composition Explorer (ACE) spacecraft in KSC's Spacecraft Assembly and Encapsulation Facility-II (SAEF-II). Scheduled for launch on a Delta II rocket from Cape Canaveral Air Station on Aug. 25, ACE will study low-energy particles of solar origin and high-energy galactic particles. The collecting power of instruments aboard ACE is 10 to 1,000 times greater than anything previously flown to collect similar data by NASA.

  19. Pathology economic model tool: a novel approach to workflow and budget cost analysis in an anatomic pathology laboratory.

    Science.gov (United States)

    Muirhead, David; Aoun, Patricia; Powell, Michael; Juncker, Flemming; Mollerup, Jens

    2010-08-01

    The need for higher efficiency, maximum quality, and faster turnaround time is a continuous focus for anatomic pathology laboratories and drives changes in work scheduling, instrumentation, and management control systems. To determine the costs of generating routine, special, and immunohistochemical microscopic slides in a large, academic anatomic pathology laboratory using a top-down approach. The Pathology Economic Model Tool was used to analyze workflow processes at The Nebraska Medical Center's anatomic pathology laboratory. Data from the analysis were used to generate complete cost estimates, which included not only materials, consumables, and instrumentation but also specific labor and overhead components for each of the laboratory's subareas. The cost data generated by the Pathology Economic Model Tool were compared with the cost estimates generated using relative value units. Despite the use of automated systems for different processes, the workflow in the laboratory was found to be relatively labor intensive. The effect of labor and overhead on per-slide costs was significantly underestimated by traditional relative-value unit calculations when compared with the Pathology Economic Model Tool. Specific workflow defects with significant contributions to the cost per slide were identified. The cost of providing routine, special, and immunohistochemical slides may be significantly underestimated by traditional methods that rely on relative value units. Furthermore, a comprehensive analysis may identify specific workflow processes requiring improvement.

  20. A crowdsourced nickel-and-dime approach to analog OBM research: A behavioral economic framework for understanding workforce attrition.

    Science.gov (United States)

    Henley, Amy J; DiGennaro Reed, Florence D; Reed, Derek D; Kaplan, Brent A

    2016-09-01

    Incentives are a popular method to achieve desired employee performance; however, research on optimal incentive magnitude is lacking. Behavioral economic demand curves model persistence of responding in the face of increasing cost and may be suitable to examine the reinforcing value of incentives on work performance. The present use-inspired basic study integrated an experiential human operant task within a crowdsourcing platform to evaluate the applicability of behavioral economics for quantifying changes in workforce attrition. Participants included 88 Amazon Mechanical Turk Workers who earned either a $0.05 or $0.10 incentive for completing a progressively increasing response requirement. Analyses revealed statistically significant differences in breakpoint between the two groups. Additionally, a novel translation of the Kaplan-Meier survival-curve analyses for use within a demand curve framework allowed for examination of elasticity of workforce attrition. Results indicate greater inelastic attrition in the $0.05 group. We discuss the benefits of a behavioral economic approach to modeling employee behavior, how the metrics obtained from the elasticity of workforce attrition analyses (e.g., P max ) may be used to set goals for employee behavior while balancing organizational costs, and how economy type may have influenced observed outcomes. © 2016 Society for the Experimental Analysis of Behavior.

  1. Concise Approach for Determining the Optimal Annual Capacity Shortage Percentage using Techno-Economic Feasibility Parameters of PV Power System

    Science.gov (United States)

    Alghoul, M. A.; Ali, Amer; Kannanaikal, F. V.; Amin, N.; Sopian, K.

    2017-11-01

    PV power systems have been commercially available and widely used for decades. The performance of a reliable PV system that fulfils the expectations requires correct input data and careful design. Inaccurate input data of the techno-economic feasibility would affect the size, cost aspects, stability and performance of PV power system on the long run. The annual capacity shortage is one of the main input data that should be selected with careful attention. The aim of this study is to reveal the effect of different annual capacity shortages on the techno-economic feasibility parameters and determining the optimal value for Baghdad city location using HOMER simulation tool. Six values of annual capacity shortage percentages (0%, 1%, 2%, 3%, 4%, and 5%), and wide daily load profile range (10 kWh - 100 kWh) are implemented. The optimal annual capacity shortage is the value that always "wins" when each techno-economic feasibility parameter is at its optimal/ reasonable criteria. The results showed that the optimal annual capacity shortage that reduces significantly the cost of PV power system while keeping the PV system with reasonable technical feasibility is 3%. This capacity shortage value can be carried as a reference value in future works for Baghdad city location. Using this approach of analysis at other locations, annual capacity shortage can be always offered as a reference value for those locations.

  2. Materials, system designs and modelling approaches in techno-economic assessment of all-vanadium redox flow batteries - A review

    Science.gov (United States)

    Minke, Christine; Turek, Thomas

    2018-02-01

    The vanadium redox flow battery (VFB) is one of the most promising stationary electrochemical storage systems. The reduction of system costs is a major challenge in the realization of its widespread application. The high complexity of this technology requires a close linking of technologic and economic aspects in system cost assessment. The present review provides an extensive literature analysis with a focus on techno-economic assessment of VFB. Considered materials, system designs and modelling approaches are assessed and compared in order to present and evaluate the current status of system cost assessment in a transparent way. Systems in a range of 2 kW-50 MW providing energy for up to 150 h are covered in literature resulting in an immense range of specific total system costs of 564-12931 € kW-1 or 89-1738 € (kWh)-1. Based on the data from the reviewed studies, guide values of 650 € (kWh)-1 and 550 € (kWh)-1 for installed VFB systems in a power range of 10-1000 kW providing energy for 4 h and 8 h respectively are derived from literature. Moreover, the relevance of precision in the definition of scope and components for meaningful results of techno-economic assessments of VFB systems is pointed out.

  3. Techno-Economic Approach to Solar Energy Systems Onboard Marine Vehicles

    Directory of Open Access Journals (Sweden)

    Salem Ahmed A.

    2016-09-01

    Full Text Available The world is facing the challenge of continuously increasing energy consumption. At the same time, the energy resources are getting scarcer. Despite a sudden significant drop of fuel prices worldwide, research activities that focus on reducing the dependence on fossil fuels as a traditional source of energy still have the preference in the field of shipping industry. The use of clean and renewable energies, such as solar energy for instance, is proposed as a method to improve the ship efficiency. Ships can get the benefits from solar energy due to the fact that most of their upper decks are always exposed to the Sun, especially in sunny water regions. The present paper discusses the effectiveness and challenges of installing solar panels for auxiliary power production on board a ship. As a case study, the research evaluates both economic and environmental benefits resulting from implementing such concept aboard a research vessel.

  4. Responsibility and Capitalism. A Phenomenological Way to Approach the Economic Crisis

    Directory of Open Access Journals (Sweden)

    Floriana Ferro

    2013-03-01

    Full Text Available The Western world is presently afflicted by a huge economic crisis, started in 2007 in the United States, with the collapse of the subprime mortgage market, and exploded in 2008 with the breakdown of Lehman Brothers[1]. Even if its most critical stage seems to be finished, capitalist countries find it difficult to recover. Globalization exported the effects of the crisis everywhere, but those that suffered the greatest damages are Europe and North America. The collapse of some financial companies is only the top of a huge iceberg. The crisis has roots in something deeper, in the principles and mechanisms of capitalism itself. The Western part of the world is still paying not for the mistakes of a few executives, but for a general lack of ethics in the whole system.

  5. APPROACHING THE ECONOMIC COSTS ASSESSMENT OF OCCUPATIONAL INJURIES AND DISEASES: PRINCIPLES, CONCEPTS AND STRUCTURE

    Directory of Open Access Journals (Sweden)

    ROLAND IOSIF MORARU

    2014-10-01

    Full Text Available Occupational Health and Safety management is more and more strongly related to the costs of occupational injuries and illnesses, as a top priority in most companies. The present article presents a synthesis of authors’ attempts to identify the elements which should be taken into account in determining the cost of occupational injuries and diseases at the national level, with a focus on basic influence factors. Our aim is to help companies managers to emphasize the economic costs of not improving workplace safety and health – to employers, to workers and to society as a whole – and to inform decision-makers on further developments to be considered in the occupational risk management processes.

  6. Economic challenges of hybrid microgrid: An analysis and approaches for rural electrification

    Science.gov (United States)

    Habibullah, Mohammad; Mahmud, Khizir; Koçar, Günnur; Islam, A. K. M. Sadrul; Salehin, Sayedus

    2017-06-01

    This paper focuses on the integration of three renewable resources: biogas, wind energy and solar energy, utilizing solar PV panels, a biogas generator, and a wind turbine, respectively, to analyze the technical and economic challenges of a hybrid micro-gird. The integration of these sources has been analyzed and optimized based on realistic data for a real location. Different combinations of these sources have been analyzed to find out the optimized combination based on the efficiency and the minimum cost of electricity (COE). Wind and solar energy are considered as the primary sources of power generation during off-peak hours, and any excess power is used to charge a battery bank. During peak hours, biogas generators produce power to support the additional demand. A business strategy to implement the integrated optimized system in rural areas is discussed.

  7. Economic growth constraints in Vietnam: A study using the growth diagnostic approach

    Directory of Open Access Journals (Sweden)

    Nguyen Duc Thanh

    2016-04-01

    Full Text Available Recent studies have clearly pointed out a decreasing trend of Vietnam’s economic growth in the short and the medium terms. This paper presents a study applying the growth diagnostic method for Vietnam to determine growth constrains. The binding growth constrains of Vietnam are found to include a poor business environment; an underdeveloped infrastructure, especially the transportation network market; failures related to information externalities, learning externalities and coordination failures. Notably, the energy infrastructure could be a vital constraint in a near future, but is not a binding constraint at present. The inefficiency of financial intermediaries and the government’s over-investment could become a binding constraint when the economy returns to its high growth path.

  8. Commoditization and oppression: a systems approach to understanding the economic dynamics of modes of oppression.

    Science.gov (United States)

    Manno, Jack P

    2010-01-01

    Commoditization is a generalized Darwinian selection pressure in economic evolution driven by profit- and efficiency-seeking in the investment of key resources. By winnowing noncommodity opportunities to satisfy human needs, commoditization distorts development in ways that intensify negative social outcomes experienced by oppressed groups and undermines the possibility for sustainable development. When market logic dominates the investment of financial capital, energy, raw materials, human attention, labor, and creativity, market goods with traits associated with commodities are fully developed while nonmarket goods lacking those traits are systematically underdeveloped. Analysis of the traits of commodities explains the unsustainable development or maldevelopment that disproportionately affects those who are dependent on or who highly value important nonmarket relationships. Oppression theory is addressed with specific examples. A generalized form of oppression is theorized that systematically stunts the imagination and creativity required to meet contemporary environmental crises.

  9. A novel chaotic particle swarm optimization approach using Henon map and implicit filtering local search for economic load dispatch

    International Nuclear Information System (INIS)

    Coelho, Leandro dos Santos; Mariani, Viviana Cocco

    2009-01-01

    Particle swarm optimization (PSO) is a population-based swarm intelligence algorithm driven by the simulation of a social psychological metaphor instead of the survival of the fittest individual. Based on the chaotic systems theory, this paper proposed a novel chaotic PSO combined with an implicit filtering (IF) local search method to solve economic dispatch problems. Since chaotic mapping enjoys certainty, ergodicity and the stochastic property, the proposed PSO introduces chaos mapping using Henon map sequences which increases its convergence rate and resulting precision. The chaotic PSO approach is used to produce good potential solutions, and the IF is used to fine-tune of final solution of PSO. The hybrid methodology is validated for a test system consisting of 13 thermal units whose incremental fuel cost function takes into account the valve-point loading effects. Simulation results are promising and show the effectiveness of the proposed approach.

  10. CONCEPTUAL BASES OF FORMING THE SYSTEM OF FINANCIAL AND ECONOMIC PROVIDING SOCIAL PROTECTION INVOLUNTARILY DISPLACED PERSONS WITH CLUSTER APPROACH

    Directory of Open Access Journals (Sweden)

    Svitlana Kropelnytska

    2017-08-01

    Full Text Available The article systematizes approaches to financial support and social adaptation of internally displaced persons (IDPs as well as their social protection, that is based on the analysis of legal framework, situation and sources of financial and social support to the EU member states of the IDPs in Ukraine and their social security. The study of the IDPs situation and the assessment of the required resources are based on a cluster approach, which defines optimal set of problem areas requiring priority social and financial support. This allowed to develop practical recommendations for the development of a comprehensive, transparent and unified policy of social protection through the development of a conceptual framework for the financial and economic provision of social protection IDPs, which will be the basic solution to the problems of social and financial provision forced migrants in Ukraine. Key words: forced migrants, internally displaced persons, cluster, social policy, social protection, social providing, financial providing.

  11. The economic impact of the insured patients with severe chronic and acute illnesses: a qualitative approach

    Directory of Open Access Journals (Sweden)

    Budi Aji

    2014-10-01

    Full Text Available Background: Little research has focused on the economic hardship among the insured with severe illnesses and high treatment costs, in particular, the consequence of poorer insurance coverage for high-cost illnesses. Therefore, we presented the case for identifying the experiences of insured patients with severe chronic and acute illnesses. This study identified a qualitative understanding of the economic impact of severe chronic and acute illnesses and household strategies to deal with high treatment costs. Design: Interviews were conducted with 19 insured households of three different health insurance programs with a family member that had been hospitalized for severe chronic or acute illnesses in either Banyumas or Margono Sukarjo hospitals in Banyumas, Central Java, Indonesia. A thematic analysis was applied to guide the interpretation of the data. Results: Insured households with a family member that had been hospitalized for severe chronic and acute illnesses were greatly affected by the high treatment costs. Four major issues emerged from this qualitative study: insured patients are still burdened with high out-of-pocket payments, households adopt various strategies to cope with the high cost of treatments, households experience financial hardships, and positive and negative perceptions of the insured regarding their health insurance coverage for acute and chronic illnesses. Conclusions: Askes and Jamsostek patients faced financial burdens from high cost sharing for hospital amenities, non-covered drugs, and treatments and other indirect costs. Meanwhile, Jamkesmas beneficiaries faced no financial burden for related medical services but were rather burdened with indirect costs for the carers. Households relied on internal resources to cover hospital bills as the first strategy, which included the mobilization of savings, sale of assets, and borrowing of money. External support was tapped secondarily and included financial support from

  12. Analysis of economic determinants of fertility in Iran: a multilevel approach.

    Science.gov (United States)

    Moeeni, Maryam; Pourreza, Abolghasem; Torabi, Fatemeh; Heydari, Hassan; Mahmoudi, Mahmood

    2014-08-01

    During the last three decades, the Total Fertility Rate (TFR) in Iran has fallen considerably; from 6.5 per woman in 1983 to 1.89 in 2010. This paper analyzes the extent to which economic determinants at the micro and macro levels are associated with the number of children in Iranian households. Household data from the 2010 Household Expenditure and Income Survey (HEIS) is linked to provincial data from the 2010 Iran Multiple-Indicator Demographic and Health Survey (IrMIDHS), the National Census of Population and Housing conducted in 1986, 1996, 2006 and 2011, and the 1985-2010 Iran statistical year books. Fertility is measured as the number of children in each household. A random intercept multilevel Poisson regression function is specified based on a collective model of intra-household bargaining power to investigate potential determinants of the number of children in Iranian households. Ceteris paribus (other things being equal), probability of having more children drops significantly as either real per capita educational expenditure or real total expenditure of each household increase. Both the low- and the high-income households show probabilities of having more children compared to the middle-income households. Living in provinces with either higher average amount of value added of manufacturing establishments or lower average rate of house rent is associated to higher probability of having larger number of children. Higher levels of gender gap indices, resulting in household's wife's limited power over household decision-making, positively affect the probability of having more children. Economic determinants at the micro and macro levels, distribution of intra-household bargaining power between spouses and demographic covariates determined fertility behavior of Iranian households.

  13. Defining and measuring blood donor altruism: a theoretical approach from biology, economics and psychology.

    Science.gov (United States)

    Evans, R; Ferguson, E

    2014-02-01

    While blood donation is traditionally described as a behaviour motivated by pure altruism, the assessment of altruism in the blood donation literature has not been theoretically informed. Drawing on theories of altruism from psychology, economics and evolutionary biology, it is argued that a theoretically derived psychometric assessment of altruism is needed. Such a measure is developed in this study that can be used to help inform both our understanding of the altruistic motives of blood donors and recruitment intervention strategies. A cross-sectional survey (N = 414), with a 1-month behavioural follow-up (time 2, N = 77), was designed to assess theoretically derived constructs from psychological, economic and evolutionary biological theories of altruism. Theory of planned behaviour (TPB) variables and co-operation were also assessed at time 1 and a measure of behavioural co-operation at time 2. Five theoretical dimensions (impure altruism, kinship, self-regarding motives, reluctant altruism and egalitarian warm glow) of altruism were identified through factor analyses. These five altruistic motives differentiated blood donors from non-donors (donors scored higher on impure altruism and reluctant altruism), showed incremental validity over TPB constructs to predict donor intention and predicted future co-operative behaviour. These findings show that altruism in the context of blood donation is multifaceted and complex and, does not reflect pure altruism. This has implication for recruitment campaigns that focus solely on pure altruism. © 2013 The Authors. Vox Sanguinis published by John Wiley & Sons Ltd. on behalf of International Society of Blood Transfusion.

  14. MSCs with ACE II gene affect apoptosis pathway of acute lung injury induced by bleomycin.

    Science.gov (United States)

    Zhang, Xiaomiao; Gao, Fengying; Li, Qian; Dong, Zhixia; Sun, Bo; Hou, Lili; Li, Zhuozhe; Liu, Zhenwei

    2015-02-01

    The aim of this study was to evaluate the effect and related mechanisms of Mesenchymal stem cells (MSCs) and Angiotensin converting enzyme II (ACE II) on acute lung injury (ALI). MSCs were separated from umbilical cord cells, and the changes of phenotype before and after ACE II silence were observed using Flow Cytometer. ALI model was induced by 10 mg/mL bleomycin in 60 Balb/c mice, and the rest 8 mice were regarded as the baseline group. The mice were randomly divided into four groups (n = 15): control, ACE II, stem, and stem + ACE II. The apoptotic index (AI) was calculated using TUNEL, and the detection of protein and mRNA of Bax, Bak and p53, Bcl-2, Grp78, CHOP and Caspase 12 were used by western-blot and RT-PCR, respectively. The umbilical cord cells differentiated into stable MSCs about 14 days, and ACE II transfection reached a peak at the 5th day after transfection. ACE II silence did not affect the phenotype of MSCs. All the proteins and mRNAs expression except Bcl-2 in the stem and stem + ACE II were significantly lower than those in control from 8 h (p ACE II performed a better effect than single stem in most indexes, including AI (p ACE II can significantly suppress apoptosis in ALI mice, and may be an effective clinical treatment for ALI.

  15. Evaluation of ACE gene I/D polymorphism in Iranian elite athletes.

    Science.gov (United States)

    Shahmoradi, Somayeh; Ahmadalipour, Ali; Salehi, Mansoor

    2014-01-01

    Angiotensin converting enzyme (ACE) is an important gene, which is associated with the successful physical activity. The ACE gene has a major polymorphism (I/D) in intron 16 that determines its plasma and tissue levels. In this study, we aimed to determine whether there is an association between this polymorphism and sports performance in our studied population including elite athletes of different sports disciplines. We investigated allele frequency and genotype distribution of the ACE gene in 156 Iranian elite athletes compared to 163 healthy individuals. We also investigated this allele frequency between elite athletes in three functional groups of endurance, power, and mixed sports performances. DNA was extracted from peripheral blood, and polymerase chain reaction (PCR) method was performed on intron 16 of the ACE gene. The ACE genotype was determined for each subject. Statistical analysis was performed by SPSS 15, and results were analyzed by Chi-Square test. There was a significant difference in genotype distribution and allele frequency of the ACE gene in athletes and control group (P = 0.05, P = 0.03, respectively). There was also a significant difference in allele frequency of the ACE gene in 3 groups of athletes with different sports disciplines (P = 0.045). Proportion of the ACE gene D allele was greater in elite endurance athletes (37 high-distance cyclists) than two other groups. Findings of the present study demonstrated that there is an association between the ACE gene I/D polymorphism and sports performance in Iranian elite athletes.

  16. Somatic ACE regulates self-renewal of mouse spermatogonial stem cells via the MAPK signaling pathway.

    Science.gov (United States)

    Gao, Tingting; Zhao, Xin; Liu, Chenchen; Shao, Binbin; Zhang, Xi; Li, Kai; Cai, Jinyang; Wang, Su; Huang, Xiaoyan

    2018-05-24

    Spermatogonial stem cell (SSC) self-renewal is an indispensable part of spermatogenesis. Angiotensin I-converting enzyme (ACE) is a zinc dipeptidyl carboxypeptidase that plays a critical role in regulation of the renin-angiotensin system. Here, we used RT-PCR and Western blot analysis to confirm that somatic ACE (sACE) but not testicular ACE (tACE) is highly expressed in mouse testis before postpartum day 7 and in cultured SSCs. Our results revealed that sACE is located on the membrane of SSCs. Treating cultured SSCs with the ACE competitive inhibitor captopril was found to inhibit sACE activity, and significantly reduced the proliferation rate of SSCs. Microarray analysis identified 651 genes with significant differential expression. KEGG pathway analysis showed that these differentially expressed genes are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway and cell cycle. sACE was found to play an important role in SSC self-renewal via the regulation of MAPK-dependent cell proliferation.

  17. Qualitative Organic Analysis: An Efficient, Safer, and Economical Approach to Preliminary Tests and Functional Group Analysis

    Science.gov (United States)

    Dhingra, Sunita; Angrish, Chetna

    2011-01-01

    Qualitative organic analysis of an unknown compound is an integral part of the university chemistry laboratory curriculum. This type of training is essential as students learn to approach a problem systematically and to interpret the results logically. However, considerable quantities of waste are generated by using conventional methods of…

  18. Quantifying the impact of weather extremes on global food security: A spatial bio-economic approach

    Directory of Open Access Journals (Sweden)

    Sika Gbegbelegbe

    2014-08-01

    Full Text Available This study uses a spatial bio-economic modelling framework to estimate the impact of the 2012 weather extreme in the USA on food security in the developing world. The study also quantifies the potential effects of a similar weather extreme occurring in 2050 under climate change. The study results indicate that weather extremes that affect maize productivity in key grain baskets can negatively affect food security in vulnerable countries. The 2012 weather extreme which occurred in the USA reduced US and global maize production by 29% compared to trend; maize consumption in the country decreased by 5% only and this resulted in less surplus maize for exports from the largest maize exporter in the world. Global maize production decreased by 6% compared to trend. The decrease in global maize production coupled with a reduction in the volume of global maize exports worsened food insecurity in eastern Africa, the Caribbean and Central America and India. The effects of the weather extreme on global food security would be worse, if the latter were to occur under climate change in 2050, assuming no climate change adaptation worldwide over the years. In addition, the hardest-hit regions would remain the same, whether the weather extreme occurs in 2012 instead of 2050: Sub-Saharan Africa (SSA, South Asia and the Latin America and Caribbean (LAC region. However, sustained growth in per capita income across world economies between 2000 and 2050 would allow few countries in SSA and the LAC region to virtually eliminate hunger within their borders. In these countries, per capita income would be high enough by 2050 to completely offset the negative effect of the weather extreme. The study results are also consistent with USDA׳s estimates on US and global maize production and consumption in 2012 after the weather extreme. Some discrepancy is found on the volume of global maize trade; this implies that the bio-economic model likely overestimates the effect of the

  19. An Approach to Modeling Complex Socio-Economic Impacts and Responses to Climate Disruption

    Science.gov (United States)

    Pikas, C. K.; Nix, M.; Ihde, A. G.; Weiss, M.; Simpkins, S.; Fountain, G. H.; Paxton, L. J.

    2011-12-01

    In this paper we describe the application of a proven methodology for modeling the complex social and economic interactions of a system under stress to the issues that are arising and will arise from global climate disruption. There is a long history in the Defense community of using what are known as strategic simulations or "wargames" to model the complex interactions between the environment, people, resources, infrastructure and the economy in a competitive environment. We describe in this paper, work that we have done on understanding how this heritage can be repurposed to help us explore how the complex interplay between climate disruption and our socio/political and economic structures will affect our future. These strategic simulations would be done under the auspices of the GAIA project (http://gaia.jhuapl.edu). While these simulations cannot definitively predict what will happen, they do illuminate non-linear feedbacks between human choices and the environment. These simulations can be focused on the global, regional, or local environment and capture the various actors (governments, agencies, resources, industries, religious/political groups, etc.) that compete to achieve their particular goals. We note that these simulations are not "zero sum" games - there need not be a winner and a loser. They are, however, competitive influence games: they represent the tools that a nation, state, faction or group has at its disposal to influence policy (diplomacy), finances, industry (economy), infrastructure, information, etc to achieve their particular goals. In the simulation, humans play various roles and understand that not everyone shares the same definition of a successful or favorable outcome. Rigorous post-analysis is used to illuminate where decisions were made that enabled or prevented a particular outcome from occurring. In addition, the simulations allow us to investigate how effective "technology injects" can be in achieving a particular, desired end

  20. Economic optimization of natural hazard protection - conceptual study of existing approaches

    Science.gov (United States)

    Spackova, Olga; Straub, Daniel

    2013-04-01

    Risk-based planning of protection measures against natural hazards has become a common practice in many countries. The selection procedure aims at identifying an economically efficient strategy with regard to the estimated costs and risk (i.e. expected damage). A correct setting of the evaluation methodology and decision criteria should ensure an optimal selection of the portfolio of risk protection measures under a limited state budget. To demonstrate the efficiency of investments, indicators such as Benefit-Cost Ratio (BCR), Marginal Costs (MC) or Net Present Value (NPV) are commonly used. However, the methodologies for efficiency evaluation differ amongst different countries and different hazard types (floods, earthquakes etc.). Additionally, several inconsistencies can be found in the applications of the indicators in practice. This is likely to lead to a suboptimal selection of the protection strategies. This study provides a general formulation for optimization of the natural hazard protection measures from a socio-economic perspective. It assumes that all costs and risks can be expressed in monetary values. The study regards the problem as a discrete hierarchical optimization, where the state level sets the criteria and constraints, while the actual optimization is made on the regional level (towns, catchments) when designing particular protection measures and selecting the optimal protection level. The study shows that in case of an unlimited budget, the task is quite trivial, as it is sufficient to optimize the protection measures in individual regions independently (by minimizing the sum of risk and cost). However, if the budget is limited, the need for an optimal allocation of resources amongst the regions arises. To ensure this, minimum values of BCR or MC can be required by the state, which must be achieved in each region. The study investigates the meaning of these indicators in the optimization task at the conceptual level and compares their