Reta'maxik Qatzij--Conociendo Nuestro Idioma (Knowing Our Language). [CD-ROM].

Science.gov (United States)

Academy for Educational Development, Washington, DC.

This CD-ROM is part of an interactive and dynamic multimedia package of information and games for learning K'iche' and Ixil. This CD-ROM includes six books in electronic format with interactive exercises that support improved bilingual and intercultural education and teacher training, specifically in the languages of K'iche' and Ixil. Books…

CD-ROM-aided Databases

Science.gov (United States)

Kusama, Hideo; Matsumoto, Toshiaki

The CD-ROM system can be used independently or as a compliment to an on-line data system. It has many of the same features as an on-line system. Nippan developed the CD-NOCS system as a reinforcement or substitute for the on-line systems of the customers (bookstores). CD-NOCS is not necessarily designed just for bookstores, it is also applicable to libraries and companies. Authors would also like to emphasize that it is important to understand the development and background of the CD-NOCS system, as well as its operations.

A condensed review of the manageral aspects of CD-ROM network system

Energy Technology Data Exchange (ETDEWEB)

Choi, Kwang

2001-10-01

This report discussed manageral aspects of CD-ROM Network system to reduce executing errors and to provide effective information services to users. The results of this study are follows. 1) Library has to decide the type fo cd-rom network system compatible to the library. 2) A way of acquiring of system purchasing budget is commom utility budgets and has to include system maintenance budget. 3) When decides a provider, it is needed to review price, maintenance ability, statistics s/w, anti-virus functions.4) System manager would be a one wide-range of knowledge about network, equipment, s/w and needs continuous education about system. 5) The system users are required to have more basic knowledge than general users other users, library has to provide various user educations and minute user manuals. 6) Purchasing of CD-ROM for network use is essential and cost-benefit analysis between on-line DB and cd-rom for one user are needed. 7) when constructing Local DB using CD-RM NETWORK SYSTEM, library give attention to copyrigths of the cd-rom. 8) To provide good services through the system, cross cooperation between library and related departments is required.

Energy & Environmental Issues Interactive CD-ROM. Version 2.0. [CD-ROM].

Science.gov (United States)

Florida State Univ., Tallahassee.

This CD-ROM presents various energy and environmental topics. "Great Energy Debate" uses video clips to explore the pros and cons of solar, coal, nuclear, and oil energy sources. "Energy Plant Tour" presents a virtual tour through a plant that converts solid waste into energy. "How Stuff Works" explains energy…

DNA: The Molecule of Life. A Multimedia CD-ROM. [CD-ROM].

Science.gov (United States)

2001

This CD-ROM is designed for classroom and individual use to teach and learn about DNA. Integrated animations, custom graphics, three-dimensional representations, photographs, and sound are featured for use in user-controlled activities. Interactive lessons are available to reinforce the subject material. Pre- and post-testing sections are also…

CD-ROM: towards a strategy for teaching and learning.

Science.gov (United States)

Aarvold, J; Walton, G

1992-12-01

Compact Disc Read Only Memory (CD-ROM) represents an exciting innovation in nurse education yet paradoxically has a potential to induce disillusionment and frustration. Purchasers of systems may well find that their investment does not bring the benefits they had been lead to expect. CD-ROM systems have the capacity to generate huge quantities of data on an equally large number of nursing topics. Arguably this very capability ensures certain 'built-in' problems. The purpose of this articles is to provide nurse teachers with information about CD-ROM, to highlight the resource implications of CD-ROM use and to consider the relative merits of various teaching and learning methods. To be worthwhile, strategies developed must be part of an information retrieval skills programme.

CD-ROM technology at the EROS data center

Science.gov (United States)

Madigan, Michael E.; Weinheimer, Mary C.

1993-01-01

The vast amount of digital spatial data often required by a single user has created a demand for media alternatives to 1/2" magnetic tape. One such medium that has been recently adopted at the U.S. Geological Survey's EROS Data Center is the compact disc (CD). CD's are a versatile, dynamic, and low-cost method for providing a variety of data on a single media device and are compatible with various computer platforms. CD drives are available for personal computers, UNIX workstations, and mainframe systems, either directly connected, or through a network. This medium furnishes a quick method of reproducing and distributing large amounts of data on a single CD. Several data sets are already available on CD's, including collections of historical Landsat multispectral scanner data and biweekly composites of Advanced Very High Resolution Radiometer data for the conterminous United States. The EROS Data Center intends to provide even more data sets on CD's. Plans include specific data sets on a customized disc to fulfill individual requests, and mass production of unique data sets for large-scale distribution. Requests for a single compact disc-read only memory (CD-ROM) containing a large volume of data either for archiving or for one-time distribution can be addressed with a CD-write once (CD-WO) unit. Mass production and large-scale distribution will require CD-ROM replication and mastering.

An x ray archive on your desk: The Einstein CD-ROM's

Science.gov (United States)

Prestwich, A.; Mcdowell, J.; Plummer, D.; Manning, K.; Garcia, M.

1992-01-01

Data from the Einstein Observatory imaging proportional counter (IPC) and high resolution imager (HRI) were released on several CD-ROM sets. The sets released so far include pointed IPC and HRI observations in both simple image and detailed photon event list format, as well as the IPC slew survey. With the data on these CD-ROMS's the user can perform spatial analysis (e.g., surface brightness distributions), spectral analysis (with the IPC event lists), and timing analysis (with the IPC and HRI event lists). The next CD-ROM set will contain IPC unscreened data, allowing the user to perform custom screening to recover, for instance, data during times of lost aspect data or high particle background rates.

CD-ROM storing JENDL-3.2 plots and data

Energy Technology Data Exchange (ETDEWEB)

Fukahori, Tokio; Iwamoto, Osamu; Nakagawa, Tsuneo; Shibata, Keiichi; Narita, Tsutomu; Katakura, Jun-ichi; Hasegawa, Akira [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1998-01-01

Numerical data and graphs of Japanese Evaluated Nuclear Data Library, Version 3, Revision 2 (JENDL-3.2) have been stored into CD-ROM. JENDL-3.2 is an evaluated nuclear data library which is highly rated in the world, and consists of neutron nuclear data and secondary gamma-ray data for 340 nuclides. JENDL-3.2 has been already released through World Wide Web (WWW, http://cracker.tokai.jaeri.go.jp). For users` convenience and to promote further utilization, this CD-ROM has been produced. The data stored in CD-ROM are the original data and point-wise data (0 K and 300 K) of JENDL-3.2 and graphs of cross sections in gif, PostScript and PDF formats. These data can be retrieved by users` personal computers and engineering workstations, and also can be seen by using WWW browsers. This CD-ROM makes user completely free from downloading, which takes a lot of time, and tedious management such a treating big amount of data. (author)

Scaffolding or Distracting: CD-ROM Storybooks and Young Readers

Science.gov (United States)

Pearman, Cathy J.; Chang, Ching-Wen

2010-01-01

CD-ROM storybooks, often referred to as electronic texts, e-books, and interactive stories, are learning tools with supplemental features such as automatic reading of text, sound effects, word pronunciations, and graphic animations which support the development of reading skills and comprehension in beginning readers. Some CD-ROM storybooks also…

Review of CD Rom

African Journals Online (AJOL)

"The Virtual Surgeon consists of a ground breaking series of CD-ROMs, which aims to provide surgeons with a new and powerful training tool. It provides surgeons with the most accurate and realistic model of the knee available, and our developments in animation allow them to see all aspects of the surgical procedure.

Environmental awareness -- An interactive multimedia CD-ROM

Energy Technology Data Exchange (ETDEWEB)

Huntelmann, A.; Petruk, M.W.

1998-07-01

As corporations move to new and innovative ways of structuring high-performance work teams, effective training is being recognized as a key to insuring success. Time and scheduling constraints tend to limit the effectiveness of traditional approaches to training. This has led Edmonton Power Inc. to explore the use of CD-ROM based multimedia as a means of delivering individualized instruction in an effective and timely manner. This session will demonstrate a multimedia CD-ROM based course on Environmental Awareness designed for workers in the electrical utilities industry. The objective of the course is to make workers aware of their roles and responsibilities with respect to their impact on the environment. This session will also describe the instructional design strategy underlying this approach to training and will present some preliminary findings with respect to the effectiveness of this approach. Individuals who are interested in improving the effectiveness of their environmental training program as well as individuals who are interested in understanding the strengths of multimedia CD-ROM based training will find this session useful and informative.

Conserving Earth's Biodiversity. [CD-ROM and] Instructor's Manual.

Science.gov (United States)

2000

This CD-ROM is designed as an interactive learning tool to support teaching in highly interdisciplinary fields such as conservation of biodiversity. Topics introduced in the software include the impact of humans on natural landscapes, threats to biodiversity, methods and theories of conservation biology, environmental laws, and relevant economic…

New Access Points to ERIC--CD-ROM Versions. ERIC Digest.

Science.gov (United States)

McLaughlin, Pamela W.

This digest reviews three CD-ROM (compact disc-read only memory) versions of the ERIC (Educational Resources Information Center) database currently being delivered or tested and provides information for comparison. However, no attempt is made to recommend any one product. The advantages and disadvantages of the acquisition of CD-ROM databases are…

The Market Place: An Internal View of the Future of CD-ROM--The Perspective of the H. W. Wilson Company.

Science.gov (United States)

Miller, Frank W.; Loeding, Deborah Voigt

1989-01-01

Discussion of technological developments in library reference services focuses on contributions of the H. W. Wilson Company and highlights CD-ROM technology. Topics discussed include online access; menu-driven systems; CD-ROM hardware and software concerns; user response to CD-ROM; quality control of databases; pricing considerations; and future…

In company pre-intermediate student's book with CD-ROM

CERN Document Server

Clarke, Simon; Sharma, Pete

2009-01-01

In Company has established itself as the Business English course for professionals because of its immediate results through topic-based content, active skills, and real-world tasks that are instantly relevant to everyday business English development. In Company Second Edition builds on the success of the original but is now updated and improved with a host of new features. For extra online practice for your students, take a look at the new Second Edition In Company Practice Online solution. Accompanying the popular In Company series in British English, these online courses provide carefully designed resources to supplement the Student's Books at all levels. Units are clearly defined as Topic or Skills based NEW phrase banks with useful phrases for reference and revision 5 NEW case studies, within the Student's Book reflect real-life business scenarios Second Edition CD-ROM now includes a new interactive glossary and the class audio as a donwloadable MP3.

Stretching & Flexibility: An Interactive Encyclopedia of Stretching. [CD-ROM].

Science.gov (United States)

2002

This CD-ROM offers 140 different stretches in full-motion video sequences. It focuses on the proper techniques for overall physical fitness, injury prevention and rehabilitation, and 23 different sports (e.g., golf, running, soccer, skiing, climbing, football, and baseball). Topics include stretching for sports; stretching awareness and education…

Type 1 Diabetes in Children: A Passport to Knowledge. [CD-ROM].

Science.gov (United States)

2001

This educational CD-ROM is designed to provide a working knowledge of diabetes and its effect on children. It is intended for parents, health care professionals, pharmacists, teachers, coaches, and child care providers. The CD-ROM examines issues related to diabetes management (food, insulin, monitoring, hypoglycemia, and illness); lifestyle; and…

NODC Standard Product: NODC Taxonomic Code on CD-ROM (NODC Accession 0050418)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The content of the NODC Taxonomic Code, Version 8 CD-ROM (CD-ROM NODC-68) distributed by NODC is archived in this accession. Version 7 of the NODC Taxonomic Code...

Development and Evaluation of a Multimedia CD-ROM for Exercise During Pregnancy and Postpartum

Science.gov (United States)

Hausenblas, Heather A.; Brewer, Britton W.; Van Raalte, Judy L.; Cook, Brian; Downs, Danielle Symons; Weis, Carol Ann; Nigg, Claudio; Cruz, Amelia

2008-01-01

Objective To meet the need for an interactive product on exercise during pregnancy and postpartum, we developed and evaluated a personally-tailored multimedia CD-ROM. Methods Pregnant and postpartum women, who were randomly assigned to either the experimental group (PregXercise™ CD-ROM) or the control group (CD-ROM with neutral content), navigated through the CD-ROM for 1 hour. Main outcomes were exercise self-efficacy and knowledge. Results In analyses of covariance, compared with the control group, the experimental group had significant increases in self-efficacy and knowledge. Conclusion The multimedia CD-ROM delivering information about exercise motivation, guidelines, and prescription was effective in improving exercise self-efficacy and knowledge. Practice Implications Our preliminary results illustrate that healthcare professionals and researchers may use interactive multimedia for improving exercise behavior and related outcomes with pregnant and postpartum women. PMID:18068940

Design issues and caching strategies for CD-ROM-based multimedia storage

Science.gov (United States)

Shastri, Vijnan; Rajaraman, V.; Jamadagni, H. S.; Venkat-Rangan, P.; Sampath-Kumar, Srihari

1996-03-01

CD-ROMs have proliferated as a distribution media for desktop machines for a large variety of multimedia applications (targeted for a single-user environment) like encyclopedias, magazines and games. With CD-ROM capacities up to 3 GB being available in the near future, they will form an integral part of Video on Demand (VoD) servers to store full-length movies and multimedia. In the first section of this paper we look at issues related to the single- user desktop environment. Since these multimedia applications are highly interactive in nature, we take a pragmatic approach, and have made a detailed study of the multimedia application behavior in terms of the I/O request patterns generated to the CD-ROM subsystem by tracing these patterns. We discuss prefetch buffer design and seek time characteristics in the context of the analysis of these traces. We also propose an adaptive main-memory hosted cache that receives caching hints from the application to reduce the latency when the user moves from one node of the hyper graph to another. In the second section we look at the use of CD-ROM in a VoD server and discuss the problem of scheduling multiple request streams and buffer management in this scenario. We adapt the C-SCAN (Circular SCAN) algorithm to suit the CD-ROM drive characteristics and prove that it is optimal in terms of buffer size management. We provide computationally inexpensive relations by which this algorithm can be implemented. We then propose an admission control algorithm which admits new request streams without disrupting the continuity of playback of the previous request streams. The algorithm also supports operations such as fast forward and replay. Finally, we discuss the problem of optimal placement of MPEG streams on CD-ROMs in the third section.

Pricing Strategies for CD-ROM Products.

Science.gov (United States)

Rowley, J. E.

1994-01-01

Pricing strategies for subscriptions and licenses for CD-ROMs are different for single users and networks. The basic components of pricing strategies are charges for subscription, connect line, display/print, telecommunication, session rate, special commands, and special services. Highlights selected supplier pricing strategies for single users…

Qualitative evaluation of a colorectal cancer education CD-ROM for Community Health Aides/practitioners in Alaska.

Science.gov (United States)

Cueva, Melany; Dignan, Mark; Lanier, Anne; Kuhnley, Regina

2014-12-01

Colorectal cancer (CRC) is an important contributor to the cancer burden among Alaska Native people. CRC is the leading incident cancer and the second leading cause of cancer mortality among Alaska Native people. Completing recommended CRC screening procedures has the potential to reduce both CRC incidence and mortality. "Taking Action Colorectal Health," a multidimensional audiovisual, interactive CD-ROM, incorporates adult education learning principles to provide Alaska's Community Health Aides/Practitioners with timely, medically accurate, and culturally relevant CRC place-based education. Providing this resource on CD-ROM empowers learning within communities and places where people live or choose to learn. The dynamic process of developing, implementing, and evaluating this CRC CD-ROM was informed by a sociocultural approach to share health messages. Within this approach, cultural values, beliefs, and behaviors are affirmed as a place of wisdom and resilience and built upon to provide context and meaning for health messaging. Alaska Native values that honor family, relationships, the land, storytelling, and humor were included in CD-ROM content. Between January and May 2012, 20 interviews were conducted with individuals who had used the CD-ROM. Four categorical themes emerged from analysis of interview transcripts: likeability, utilization, helpfulness, and behavior change. As a result of self-paced learning through stories, movies, and interactive games, respondents reported healthy behavior changes they were making for themselves, with their families and in their patient care practices. This CD-ROM is a culturally based practical course that increased knowledge and activities around colorectal cancer screening by Community Health Aides/Practitioners in Alaska.

Marketing and Selling CD-ROM Products on the World-Wide Web.

Science.gov (United States)

Walker, Becki

1995-01-01

Describes three companies' approaches to marketing and selling CD-ROM products on the World Wide Web. Benefits include low overhead for Internet-based sales, allowance for creativity, and ability to let customers preview products online. Discusses advertising, information delivery, content, information services, and security. (AEF)

Networking CD-ROMs: The Decision Maker's Guide to Local Area Network Solutions.

Science.gov (United States)

Elshami, Ahmed M.

In an era when patrons want access to CD-ROM resources but few libraries can afford to buy multiple copies, CD-ROM local area networks (LANs) are emerging as a cost-effective way to provide shared access. To help librarians make informed decisions, this manual offers information on: (1) the basics of LANs, a "local area network primer";…

The Basic Economics of CD-ROM Pricing.

Science.gov (United States)

Erkkila, John E.

1991-01-01

This explanation of how the basic economic model of pricing applies to the CD-ROM industry considers the supply and demand sides of the market and compares three distinct pricing strategies: (1) pricing to maximize profits; (2) average cost pricing; and (3) marginal cost pricing. (EAM)

The New York Trade Publishers and CD-ROM: Where Are They Heading?

Science.gov (United States)

Newmark, Eileen

1994-01-01

Discusses the strategies top trade publishers, including Putnam New Media, Paramount Communications, Random House, Penguin USA, and Reader's Digest, are taking toward CD-ROM publishing. Strategies include purchasing electronic media companies; setting up an independent business; and building a new media business by integrating new efforts into the…

Ionospheric data available on CD-ROM and on NDADS

International Nuclear Information System (INIS)

Bilitza, D.

1996-01-01

Information is provided on two CD-ROMs (for PCs) with ionospheric data: the ionosonde CD issued by NGDC/WDC-A-STP/NOAA/Boulder and the Atmosphere Explorer CD produced by NSSDC/WDC-A-R and S/NASA/Greenbelt. We also briefly describe the ionospheric/thermospheric data available through NSSDC's automated mail retrieval system (NDADS) and explain the procedure for obtaining NDADS data. (author). 3 figs

Review of Cornaline de l'Inde/Carnelian in India CD-Rom.

Directory of Open Access Journals (Sweden)

Peter Grave

2002-10-01

Full Text Available The CD-Rom format has been around for some time now with CD-Rom readers a standard fitting on even the most basic PC. The strength of this technology is that it enables large amounts of data to be stored (650-700 MB on a reliable, portable and economical medium. The character of data stored is virtually only dependant on developments in the hardware and software used to generate and manage datasets, whether numeric arrays, databases, digital imagery or multimedia. These features have made it a popular mode for a diverse range of interactive educational, reference and entertainment software. As a medium that can hold thousand of 'pages' of text, spreadsheets, colour images, animations and digital movies, CD-Rom technology also offers obvious benefits for the delivery of the diversity of data produced by archaeological research. It is surprising then that projects such as the bilingual Cornaline de l'Inde/Carnelian in India are few and far between.

Studi Korelasi Motivasi Pengguna Dengan Pemanfaatan Koleksi CD-ROM Di UPT Pusat Perpustakaan UII Yogyakarta (Study on Correlation Between The Motivation of Users and The Use of CD-ROM Collection At The Main Library of Indonesia Islamic University of Yogyakarta

Directory of Open Access Journals (Sweden)

Keni Hesti Handayani

2015-12-01

Full Text Available The research addresses three main issues: student motivation of Indonesia Islamic University of Yogyakarta, the use of CD-ROM collection at the main library of Indonesia Islamic University of Yogyakarta, and the correlation between student motivation and the use of CD-ROM collection at the library. The study uses a field research. The sample is accidental sampling which involves students using the collection of CD-ROM at the library. In the term of data collection, the writer uses some techniques those of which are documentation, observation, interview and questionnaire. The result of the research shows that, there are correlation between the motivation and the use of CD-ROM collection at the main library of Indonesia Islamic University of Yogyakarta. The research is hoped to contribute to the improvement of services of CD-ROM collection at library in particular and to the development of through collection at the library. Keyword: user motivation, the use of CD-ROM collection

The systems prioritization method (SPM) CD-ROM demonstration for Waste Management '96

International Nuclear Information System (INIS)

Harris, C.L.; Boak, D.M.; Prindle, N.H.; Beyeler, W.

1996-01-01

In March 1994, the Department of Energy Carlsbad Area Office (DOE/CAO) implemented a performance-based planning method to assist in prioritization within the Waste Isolation Pilot Plant (WIPP). Probabilistic performance calculations were required for the Systems Prioritization Method (SPM) and roughly 46,700 combinations of activities were analyzed, generating a large volume of information to be documented, analyzed, and communicated. A self-contained information management system consisting of a relational database on a 600-megabyte CD-ROM was built to meet this need. The CD-ROM was used to store performance assessment results, data analysis and visualization tools, information about the activities, electronic copies of 40 ILFR 191 and 40 CFR 268, technical reference papers, and the final SPM report. Copies of the CD-ROM were distributed to interested members of the public, WIPP participants, and the Environmental Protection Agency (EPA)

Use of CD-Rom databases by staff and students in the University of ...

African Journals Online (AJOL)

The focus of this study is the use of CD-ROM databases by staff and students in the university of Jos library. This is of interest as CD-ROM database services is in consonant with the vision of providing excellent and effective information services to all staff and students of university of Jos. The study was guided by six ...

Public census data on CD-ROM at Lawrence Berkeley Laboratory

Energy Technology Data Exchange (ETDEWEB)

Merrill, D.W.

1992-07-02

In connection with the Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socioeconomic and geographic data files which are available to CEDR and PAREP collaborators via LBL's computing network. At this time 67 CD-ROM diskettes (approximately 35 gigabytes) are on line via the Unix file server cedrcd.lbl.gov. Most of the files are from the US Bureau of the Census, and most pertain to the 1990 Census of Population and Housing. This paper contains a list of the CD-ROMs available.

Evaluation of the acceptability of a CD-Rom as a health promotion tool for Inuit in Ottawa.

Science.gov (United States)

McShane, Kelly E; Smylie, Janet K; Hastings, Paul D; Prince, Conrad; Siedule, Connie

2013-01-01

There are few health promotion tools for urban Inuit, and there is a specific dearth of evaluations on such tools. The current study used a community-specific approach in the evaluation of a health promotion tool, based on an urban Inuit community's preferences of health knowledge sources and distribution strategies. In partnership with the Tungasuvvingat Inuit Family Health Team in Ottawa, a CD-Rom was developed featuring an Inuk Elder presenting prenatal health messages in both Inuktitut and English. Also, relevant evaluation materials were developed. Using a mixed methods approach, 40 participants completed interviews prior to viewing the CD-Rom and participated in a focus group at follow-up. Questionnaires were also completed pre- and post-viewing to assess changes between expectations and reactions in order to document acceptability. Significant increases were found on satisfaction, acceptability of medium and relevance of content ratings. Qualitative findings also included (a) interest, uncertainty and conditional interest prior to viewing; and (b) positive evaluations of the CD-Rom. This suggests that CD-Rom technology has the potential for health promotion for urban Inuit, and the community-specific evaluation approach yielded useful information.

Dea Computrix - another deity for the Roman Pantheon? Journeys in the Roman Empire CD-Rom

Directory of Open Access Journals (Sweden)

T. Sam N. Moorhead

2002-08-01

Full Text Available This article outlines a personal view on the content and production of a CD-Rom on the Roman world produced by The British Museum, Channel 4, Verulamium Museum and Braunarts: Journeys in the Roman Empire. I discuss some of the benefits of and problems with multimedia production and outline feedback from various evaluation projects of the CD-Rom. I also briefly discuss the future of CD-Roms in the face of a rapidly expanding internet with reference to other multimedia projects at The British Museum.

Setting Up CD-ROM Work Areas. Part I: Ergonomic Considerations, User Furniture, Location.

Science.gov (United States)

Vasi, John; LaGuardia, Cheryl

1992-01-01

The first of a two-part series on design of CD-ROM work areas in libraries discusses (1) space and location considerations; (2) ergonomics, including work surface, chairs, lighting, printers, other accessories, and security; and (3) other considerations, including staff assistance, reference tools, literature racks, and promotional materials. (MES)

Utilizing the Evaluation Process in CD-ROM Development.

Science.gov (United States)

Crews, Tena B.; Chalupa, Marilyn R.

1999-01-01

While a CD-ROM on network topologies was being developed, it was evaluated formatively by 14 office systems teachers and summatively by 23 students using it in class. Improvements in ease of use, performance, and the accuracy and clarity of content were made. (SK)

The Virtual Man Project's CD-ROM "Voice Assessment: Speech-Language Pathology and Audiology & Medicine", Vol.1

Directory of Open Access Journals (Sweden)

Millena Maria Ramalho Matta Vieira

2009-01-01

Full Text Available The CD-ROM "Voice Assessment: Speech-Language Pathology and Audiology & Medicine" was developed as a teaching tool for people interested in the production of the spoken or sung human voice. Its content comprises several subjects concerning the anatomy and physiology of spoken and sung voice. A careful assessment becomes necessary in order to ensure the effectiveness of teaching and learning educational materials, whether related to education or health, within the proposal of education mediated by technology. OBJECTIVE: This study aimed to evaluate the efficacy of the Virtual Man Project's CD-ROM "Voice Assessment: Speech-Language Pathology and Audiology & Medicine", as a self-learning material, in two different populations: Speech-Language Pathology and Audiology students and Lyrical Singing students. The participants were instructed to study the CD-ROM during 1 month and answer two questionnaires: one before and another one after studying the CD-ROM. The quantitative results were compared statistically by the Student's t-test at a significance level of 5%. RESULTS: Seventeen out of the 28 students who completed the study, were Speech-Language Pathology and Audiology students, while 11 were Lyrical Singing students (dropout rate of 44%. Comparison of the answers to the questionnaires before and after studying the CD-ROM showed a statistically significant increase of the scores for the questionnaire applied after studying the CD-ROM for both Speech-Language Pathology and Audiology and Lyrical Singing students, with p<0.001 and p<0.004, respectively. There was also a statistically significant difference in all topics of this questionnaire for both groups of students. CONCLUSION: The results concerning the evaluation of the Speech-Language Pathology and Audiology and Lyrical Singing students' knowledge before and after learning from the CD-ROM allowed concluding that the participants made significant improvement in their knowledge of the proposed

Public census data on CD-ROM at Lawrence Berkeley Laboratory

Energy Technology Data Exchange (ETDEWEB)

Merrill, D.W.

1993-01-16

The Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socioeconomic and geographic data files which are available to CEDR and PAREP collaborators via LBL's computing network. At this time 72 CD-ROM diskettes (approximately 37 gigabytes) are on line via the Unix file server cedrcd.lbl.gov''. Most of the files are from the US Bureau of the Census, and many of these pertain to the 1990 Census of Population and Housing. All the CD-ROM diskettes contain documentation in the form of ASCII text files. In addition, printed documentation for most files is available for inspection at University of California Data and Technical Assistance (UC DATA), tel. (510) 642-6571, or the UC Documents Library, tel. (510) 642-2569, both located on the UC Berkeley Campus. Many of the CD-ROM diskettes distributed by the Census Bureau contain software for PC compatible computers, for easily accessing the data. Shared access to the data is maintained through a collaboration among the CEDR and PAREP projects at LBL, and UC DATA, and the UC Documents Library. LBL is grateful to UC DATA and the UC Documents Library for the use of their CD-ROM diskettes. Shared access to LBL facilities may be restricted in the future if costs become prohibitive. Via the Sun Network File System (NFS), these data can be exported to Internet computers for direct access by the user's application program(s). Due to the size of the files, this access method is preferred over File Transfer Protocol (FTP) access. Please contact Deane Merrill (dwmerrill lbl.gov) if you wish to make use of the data.

CD roms and multimedia projector as complimentary educational ...

African Journals Online (AJOL)

This paper examines the potentials of utilizing Compact Disk Read Only Memory (CD-ROM) and the multimedia projector as complimentary educational technology for teaching music in colleges of education in Nigeria. While recognizing the problem of ineffective methods of teaching in Nigeria's educational system, the ...

Public census data on CD-ROM at Lawrence Berkeley Laboratory

Energy Technology Data Exchange (ETDEWEB)

Merrill, D.W.

1992-10-01

The Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socio-economic and geographic data files which are available to CEDR and PAREP collaborators via LBL's computing network. At this time 70 CD-ROM diskettes (approximately 36 gigabytes) are on line via the Unix file server cedrcd. lbl. gov. Most of the files are from the US Bureau of the Census, and most pertain to the 1990 Census of Population and Housing. All the CD-ROM diskettes contain documentation in the form of ASCII text files. Printed documentation for most files is available for inspection at University of California Data and Technical Assistance (UC DATA), or the UC Documents Library. Many of the CD-ROM diskettes distributed by the Census Bureau contain software for PC compatible computers, for easily accessing the data. Shared access to the data is maintained through a collaboration among the CEDR and PAREP projects at LBL, and UC DATA, and the UC Documents Library. Via the Sun Network File System (NFS), these data can be exported to Internet computers for direct access by the user's application program(s).

Public census data on CD-ROM at Lawrence Berkeley Laboratory

Energy Technology Data Exchange (ETDEWEB)

Merrill, D.W.

1992-10-01

The Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socio-economic and geographic data files which are available to CEDR and PAREP collaborators via LBL`s computing network. At this time 70 CD-ROM diskettes (approximately 36 gigabytes) are on line via the Unix file server cedrcd. lbl. gov. Most of the files are from the US Bureau of the Census, and most pertain to the 1990 Census of Population and Housing. All the CD-ROM diskettes contain documentation in the form of ASCII text files. Printed documentation for most files is available for inspection at University of California Data and Technical Assistance (UC DATA), or the UC Documents Library. Many of the CD-ROM diskettes distributed by the Census Bureau contain software for PC compatible computers, for easily accessing the data. Shared access to the data is maintained through a collaboration among the CEDR and PAREP projects at LBL, and UC DATA, and the UC Documents Library. Via the Sun Network File System (NFS), these data can be exported to Internet computers for direct access by the user`s application program(s).

Operating Experience with Nuclear Power Stations in Member States in 2013. 2014 Edition (CD-ROM)

International Nuclear Information System (INIS)

2014-07-01

This CD-ROM contains the 45th edition of the IAEA's series of annual reports on operating experience with nuclear power plants in Member States. It is a direct output from the IAEA's Power Reactor Information System (PRIS) and contains information on electricity production and overall performance of individual plants during 2013. In addition to annual information, the report contains a historical summary of performance during the lifetime of individual plants and figures illustrating worldwide performance of the nuclear industry. The CD-ROM contains also an overview of design characteristics and dashboards (not included into the web version) of all operating nuclear power plants worldwide

Cd-Rom and Access to Information

OpenAIRE

Chacón Alvarado, Lucía

2011-01-01

The scientific and technological advances in the world and its application in different areas of knowledge have developed a new electronic age.Computers and telecommunications have created a new scenario for libraries and information centers leading to further changes in the use of its collections and its services increased. Libraries and information centers must address these changes because users demand access to information quickly and efficiently.The CD-ROM is a new technology that has be...

Caspian Sea Energy: Oil, Politics and Development in the Caspian Sea Region (CD-ROM)

National Research Council Canada - National Science Library

Light, Chris

2004-01-01

...: 1 CD-ROM; 4 3/4 in.; 5.0 MB. ABSTRACT: The purpose of this paper is to present the major issues impacting Caspian hydrocarbon development Specifically, a number of topics including the regions geography, history, governments, politics...

Effects of Using Human Patient Simulator (HPS versus a CD-ROM on Cognition and Critical Thinking

Directory of Open Access Journals (Sweden)

Don Johnson, PhD

2008-01-01

Full Text Available Background: Very little prospective randomized experimental research exists on the use of simulation as a teaching method, and no studies have compared the two strategies of using the HPS and a CD-ROM. In addition, no researchers have investigated the effects of simulation on various levels of cognition, specifically lower-level and higher-level cognition or critical thinking.Objectives: A prospective pretest-posttest experimental mixed design (within and between was used to determine if there were statistically significant differences in HPS and CD-ROM educational strategies in lower-level, higher-level cognition and critical thinking.Results: A repeated measures multivariate analysis of variance (RMANOVA with LSD post-hoc tests were used to analyze the data. There were no significant differences between the HPS and CD-ROM groups on lower-level cognition scores. The HPS group did significantly better than the CD-ROM group on higher-level cognition and critical thinking scores.Conclusion: This study demonstrated that the choice of teaching strategies for lower-level cognition does not make a statistically significant difference in outcome. However, the HPS is superior to using CD-ROM and should be considered as the choice in teaching.

OCONUS Compliance Assessment Protocols - Qatar (Army Version) (CD-ROM)

National Research Council Canada - National Science Library

Krooks, David A

2004-01-01

...: 1 CD-ROM; 4 3/4 in.; 578 KB. ABSTRACT: This environmental compliance assessment manual is based on the Final Governing Standards for Environmental Security of United States Forces in the State of Qatar, 21 May 1999, and the Overseas...

CD ROM 'Natural heritage of Slovakia'

International Nuclear Information System (INIS)

Uradnikova, B.

2005-01-01

Centre of Environmental Education Geopark ('Centre') applied environmental education into school and out-of-school institutions. The 'Centre' is working in the fields: environmental education, eco-tourism development, presentation of the cultural landscape and world heritage. The CD ROM 'Natural heritage of Slovakia' was created with aim enhancement of environmental awareness, pedagogy, education and development of eco-tourism on the Slovakia. It abets general review about environment, its components, legislative, history and the present day of nature and landscape protection

A Look at Dialog's First CD-ROM Product.

Science.gov (United States)

Duggan, Mary Kay

1987-01-01

Discusses reasons for selecting ERIC with the Dialog OnDisc software for training information professionals in online searching at the University of California, Berkeley, and analyzes some of the features of the CD-ROM software. Pros and cons of online and OnDisc access are summarized, and three references are listed. (Author/MES)

Lab Manual & Resources for Materials Science, Engineering and Technology on CD-Rom

Science.gov (United States)

Jacobs, James A.; McKenney, Alfred E.

2001-01-01

The National Educators' Workshop (NEW:Update) series of workshops has been in existence since 1986. These annual workshops focus on technical updates and laboratory experiments for materials science, engineering and technology, involving new and traditional content in the field. Scores of educators and industrial and national laboratory personnel have contributed many useful experiments and demonstrations which were then published as NASA Conference Proceedings. This "out poring of riches" creates an ever-expanding shelf of valuable teaching tools for college, university, community college and advanced high school instruction. Now, more than 400 experiments and demonstrations, representing the first thirteen years of NEW:Updates have been selected and published on a CD-ROM, through the collaboration of this national network of materials educators, engineers, and scientists. The CD-ROM examined in this document utilizes the popular Adobe Acrobat Reader format and operates on most popular computer platforms. This presentation provides an overview of the second edition of Experiments in Materials Science, Engineering and Technology (EMSET2) CD-ROM, ISBN 0-13-030534-0.

The Writing Process for "Edutaining" CD-ROM Adventures.

Science.gov (United States)

Mountain, Lee

2000-01-01

Describes a CD-ROM adventure story written by the author to educate her students about the word relationships of synonyms and antonyms. Discusses how this interactive medium put a different twist on each of the stages of the writing process itself. Relates how two students enthusiastically used the program, and were inspired to write one of their…

Multimedia CD-Rom on hydrogen and fuel cells. 2. rev. ed.; Die Multimedia CD-Rom zum Thema Wasserstoff und Brennstoffzellen

Energy Technology Data Exchange (ETDEWEB)

Anon.

2007-07-01

This CD-Rom contains well-presented information with informative illustrations, as well as a large download section with publications, reports, and presentations in.pdf form for in-depth studies. There is also a list of links to selected websites, with short explanations. [German] Die CD zum Thema ''Wasserstoff und Brennstoffzellen'' bietet sowohl gut gegliederte Informationen mit anschaulichen Bildern fuer die Lektuere am Monitor als auch eine grosse Download-Rubrik, in der zahlreiche Publikationen, Fachberichte, Praesentationen als PDF-Dateien abgelegt sind und fuers Studium bereitstehen. Ausserdem gibt es ein Link-Verzeichnis mit Verweisen und Erlaeuterungen zu ausgewaehlten Internet-Seiten.

Land and Marine Gravity Data on CD-ROM - 1999 Edition

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Land and Marine Gravity 1999 Edition 2-volume CD-ROM set contains observed and derived land and marine gravity data contributed by many national and...

Nanotechnology Aerospace Applications (Applications aerospatiales de la nanotechnologie) (CD-ROM)

National Research Council Canada - National Science Library

2007-01-01

...: 1 CD-ROM; 4 3/4 in.; 116 MB. ABSTRACT: The Educational Notes contain the abstracts and the lecture material of ten presentations, which provide a general introduction into nanotechnologies with selected topics, such as nanotechnology...

Nanotechnology Aerospace Applications (Applications aerospatiales de la nanotechnologie) (CD-ROM)

National Research Council Canada - National Science Library

2005-01-01

...: 1 CD-ROM; 4 3/4 in.; 59.1 MB. ABSTRACT: The Educational Notes contain the abstracts and the lecture material of ten presentations, which provide a general introduction into nanotechnologies with selected topics, such as nanotechnology...

Management of CD-ROM Resources in Nigeria Academic Libraries ...

African Journals Online (AJOL)

The study is on management of CD-ROM resources in Nigerian academic libraries with reference to Federal Polytechnic Nekede Library, Owerri. A descriptive survey method was adopted random sampling technique was used in selecting twenty five (25) staff from the library under study. The questionnaire was the major ...

Guide Structures in CD-ROM Dic- tionaries, with Specific Reference ...

African Journals Online (AJOL)

Not all the search options in CD-ROM dictionaries necessarily maintain the boundaries ... In this article all derivatives of lase are highlighted in the microstructure, ... searches frustrates the user and should be addressed in future editions of the.

Public census data on CD-ROM at Lawrence Berkeley Laboratory. Revision 4

Energy Technology Data Exchange (ETDEWEB)

Merrill, D.W.

1993-03-12

The Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socioeconomic and geographic data files which are available to CEDR and PAREP collaborators via LBL`s computing network. At this time 89 CD-ROM diskettes (approximately 45 gigabytes) are on line via the Unix file server cedrcd.lbl.gov. Most of the files are from the US Bureau of the Census, and many of these pertain to the 1990 Census of Population and Housing. All the CD-ROM diskettes contain documentation in the form of ASCII text files. In addition, printed documentation for most files is available for inspection at University of California Data and Technical Assistance (UC DATA), tel. (510) 642-6571, or the UC Documents Library, tel. (510) 642-2569, both located on the UC Berkeley Campus. Many of the CD-ROM diskettes distributed by the Census Bureau contain software for PC compatible computers, for easily accessing the data. Shared access to the data is maintained through a collaboration among the CEDR and PAREP projects at LBL, and UC DATA, and the UC Documents Library. LBL is grateful to UC DATA and the UC Documents Library for the use of their CD-ROM diskettes. Shared access to LBL facilities may be restricted in the future if costs become prohibitive. Via the Sun Network File System (NFS), these data can be exported to Internet computers for direct access by the user`s application program(s). Due to the size of the files, this access method is preferred over File Transfer Protocol (FTP) access.

Public census data on CD-ROM at Lawrence Berkeley Laboratory. Revision 1

Energy Technology Data Exchange (ETDEWEB)

Merrill, D.W.

1992-07-02

In connection with the Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socioeconomic and geographic data files which are available to CEDR and PAREP collaborators via LBL`s computing network. At this time 67 CD-ROM diskettes (approximately 35 gigabytes) are on line via the Unix file server cedrcd.lbl.gov. Most of the files are from the US Bureau of the Census, and most pertain to the 1990 Census of Population and Housing. This paper contains a list of the CD-ROMs available.

Effects of using simulation versus CD-ROM in the performance of ultrasound-guided regional anesthesia.

Science.gov (United States)

Gasko, John; Johnson, Arthur; Sherner, John; Craig, John; Gegel, Brian; Burgert, James; Sama, Samuel; Franzen, Thomas

2012-08-01

The purpose of this study was to determine which method of teaching, CD-ROM, simulation, or a combination of both, was more effective in increasing the performance of ultrasound-guided regional anesthesia. No studies have investigated these methods. The framework for this study was critical thinking. The study was a prospective, mixed (between and within) subjects, experimental design. The sample consisted of 29 student registered nurse anesthetists randomly assigned to 1 of 3 groups: CD-ROM (n = 11), simulation (n = 11), and combination (n = 7). All groups were evaluated by the use of cadavers before and 2 months after the intervention using a valid and reliable instrument of performance. A repeated-measures analysis of variance indicated that the combination was significantly better than the CD-ROM and simulation (P teaching ultrasound-guided regional anesthesia techniques.

Reservoir and civil engineering geophysics (CD-Rom); Geophysique de gisement et de genie civil (CD-Rom)

Energy Technology Data Exchange (ETDEWEB)

Mari, J.L.; Chapellier, D.

1999-07-01

This CD-Rom is a pedagogical tool developed from the book 'field and civil engineering geophysics' (Technip ed., 1998). It presents the geophysical methods (surface and well geophysical surveys, radar surveys and well logging) and their application in the study of oil fields and also in civil engineering. Several cartoons illustrate the principle of methods, their domain of use and their limitations. It covers the following topics: surface seismic surveys (waves propagation, equipments, reflexion and refraction seismic surveys, surface waves); well seismic surveys (operation, data processing, imaging); well logging (acoustic, nuclear,electrical and others, methods of interpretation); radar surveys (principle, surface, wells, possibilities and limitations). (J.S.)

Public census data on CD-ROM at Lawrence Berkeley Laboratory. Revision 3

Energy Technology Data Exchange (ETDEWEB)

Merrill, D.W.

1993-01-16

The Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socioeconomic and geographic data files which are available to CEDR and PAREP collaborators via LBL`s computing network. At this time 72 CD-ROM diskettes (approximately 37 gigabytes) are on line via the Unix file server ``cedrcd.lbl.gov``. Most of the files are from the US Bureau of the Census, and many of these pertain to the 1990 Census of Population and Housing. All the CD-ROM diskettes contain documentation in the form of ASCII text files. In addition, printed documentation for most files is available for inspection at University of California Data and Technical Assistance (UC DATA), tel. (510) 642-6571, or the UC Documents Library, tel. (510) 642-2569, both located on the UC Berkeley Campus. Many of the CD-ROM diskettes distributed by the Census Bureau contain software for PC compatible computers, for easily accessing the data. Shared access to the data is maintained through a collaboration among the CEDR and PAREP projects at LBL, and UC DATA, and the UC Documents Library. LBL is grateful to UC DATA and the UC Documents Library for the use of their CD-ROM diskettes. Shared access to LBL facilities may be restricted in the future if costs become prohibitive. Via the Sun Network File System (NFS), these data can be exported to Internet computers for direct access by the user`s application program(s). Due to the size of the files, this access method is preferred over File Transfer Protocol (FTP) access. Please contact Deane Merrill (dwmerrill@lbl.gov) if you wish to make use of the data.

Operating Experience with Nuclear Power Stations in Member States. 2016 Edition (CD-ROM)

International Nuclear Information System (INIS)

2016-06-01

This CD-ROM contains the 47th edition of the IAEA’s series of annual reports on operating experience with nuclear power plants in Member States. It is a direct output from the IAEA’s Power Reactor Information System (PRIS) and contains information on electricity production and overall performance of individual plants during 2015. In addition to annual information, the report contains a historical summary of performance during the lifetime of individual plants and figures illustrating worldwide performance of the nuclear industry. The CD-ROM contains also an overview of design characteristics and dashboards of all operating nuclear power plants worldwide

OCONUS Compliance Assessment Protocols (OCAP) - Saudi Arabia (Army Version) (CD-ROM)

National Research Council Canada - National Science Library

Krooks, David A; Schell, Donna J

2004-01-01

...: 1 CD-ROM; 4 3/4 in.; 670 KB. ABSTRACT: This environmental compliance assessment manual is based on the Final Governing Standards for Environmental Security by United States Forces in the Kingdom of Saudi Arabia (FGS-SA...

Natural Tasking of Robots Based on Human Interaction Cues (CD-ROM)

National Research Council Canada - National Science Library

Brooks, Rodney A

2005-01-01

...: 1 CD-ROM; 4 3/4 in.; 207 MB. ABSTRACT: We proposed developing the perceptual and intellectual abilities of robots so that in the field, war-fighters can interact with them in the same natural ways as they do with their human cohorts...

NODC Standard Product: World Ocean Circulation Experiment (WOCE) Global Data Resource (GDR), versions 1-3, on CD-ROM and DVD

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — NODC produced twelve (12) CD-ROMs containing WOCE Version 1 project data in the summer of 1998. NODC produced fifteen (15) CD-ROMs containing WOCE Version 2 project...

Planning and Preparation for CD-ROM Implementation: The Citadel Library.

Science.gov (United States)

Maynard, J. Edmund

Management guidelines for library planning and a strategic planning program profile based on the literature were used in the planning process for implementing access to databases on CD-ROM at the Daniel Library of the Citadel, Military College of South Carolina. According to this model, the planning process would consist of five stages: (1)…

Canister Design for Deep Borehole Disposal of Nuclear Waste (CD-ROM)

National Research Council Canada - National Science Library

Hoag, Christopher I

2006-01-01

...: 1 CD-ROM; 4 3/4 in.; 28.7 MB. ABSTRACT: The objective of this thesis was to design a canister for the disposal of spent nuclear fuel and other high-level waste in deep borehole repositories using currently available and proven oil, gas...

Air Force Research Laboratorv Success Stories: A Review of 2004 (CD-ROM)

National Research Council Canada - National Science Library

2004-01-01

...). PHYSICAL DESCRIPTION: 1 CD-ROM; 4 3/4 in.; 43.5 MB. ABSTRACT: The Air Force Science and Technology Success Stories herein often represent the combined effort of several scientists and engineers working as a team...

Analysis of Users' Searches of CD-ROM Databases in the National and University Library in Zagreb.

Science.gov (United States)

Jokic, Maja

1997-01-01

Investigates the search behavior of CD-ROM database users in Zagreb (Croatia) libraries: one group needed a minimum of technical assistance, and the other was completely independent. Highlights include the use of questionnaires and transaction log analysis and the need for end-user education. The questionnaire and definitions of search process…

Students' Attitudes toward ABI/INFORM on CD-ROM: A Factor Analysis.

Science.gov (United States)

Wang, Vicky; Lau, Shuk-fong

Two years after the introduction of CD-ROM bibliographic database searching in the Memphis State University libraries (Tennessee), a survey was conducted to examine students' attitudes toward the business database, ABI/INFORM. ABI/INFORM contains indexes and abstracts of articles from over 800 journals on management, accounting, banking, human…

Energy-Smart Choices for Schools. An HVAC Comparison Tool. [CD-ROM].

Science.gov (United States)

Geothermal Heat Pump Consortium, Inc., Washington, DC.

A CD ROM program provides comparison construction cost capabilities for heating, ventilation, and air conditioning (HVAC) systems in educational facilities. The program combines multiple types of systems with square footage data on low and high construction cost and school size to automatically calculate HVAC comparative construction costs. (GR)

In Praise of Mr. S. Platter and His Marvelous, Magnificent CD ROM Laser Disc Index for ERIC and PSYCHLIT.

Science.gov (United States)

Huffman, Robert F.

These instructions are designed to help patrons of the University of Missouri-Columbia library perform searches on PSYCHLIT, a CD-ROM (compact disc, read only memory) version of the Psych Abstracts database, and a CD-ROM version of the ERIC database, both produced by SilverPlatter Information Services. Basic information is provided about the disk…

Operating Experience with Nuclear Power Stations in Member States in 2014. 2015 Edition (CD-ROM)

International Nuclear Information System (INIS)

2015-01-01

This CD-ROM contains the 46th edition of the IAEA’s series of annual reports on operating experience with nuclear power plants in Member States. It is a direct output from the IAEA’s Power Reactor Information System (PRIS) and contains information on electricity production and overall performance of individual plants during 2014. In addition to annual information, the report contains a historical summary of performance during the lifetime of individual plants and figures illustrating worldwide performance of the nuclear industry. The CD-ROM contains also an overview of design characteristics and dashboards of all operating nuclear power plants worldwide

Development and testing of a CD-ROM program for improving adolescent knowledge of inflammatory bowel disease.

Science.gov (United States)

Boamah, Lynelle M; Bohren, Janet R; Pentiuk, Scott; Baker, Raymond; Yi, Michael; Moyer, M Susan

2010-05-01

The aim of this study was to design a theory-based educational program for adolescents with inflammatory bowel disease (IBD) using an interactive multimedia CD-ROM and to test its effectiveness in improving knowledge in IBD. Curriculum-based instruction using educational theory and principles was designed for adolescents on an interactive multimedia CD-ROM. Twenty subjects completed summative evaluation of the CD-ROM measuring gain in knowledge about IBD immediately and 9 months after instruction. Subjects found the CD-ROM to be informative, appealing, and easy to use. The mean baseline score of the adolescents on the Crohn's and Colitis Knowledge questionnaire was 12.2 (standard deviation 5.14, range 3-24). After an average of 30 minutes of self-directed learning, adolescent subjects increased their posttest score to a mean of 19.8, a gain of 7.6 points over baseline (95% confidence interval 5.2-10.1, P < 0.0001). Knowledge of medications, disease complications, and gastrointestinal structure and function was gained and retained upon retesting at 9 months with a mean Crohn's and Colitis Knowledge questionnaire score of 17.5 (standard deviation 3.9, range 12-26), which was still an improvement over the mean pretest knowledge score of 12.2 (P < 0.001). Adolescents with IBD have low baseline knowledge about their disease. A rigorously developed interactive educational tool is now available for instructing adolescent patients about their IBD.

CD-ROM training course in quality assurance in diagnostic imaging

International Nuclear Information System (INIS)

Khoury, H.J.; Machado, P.; Drexler, G.

2001-01-01

This paper discusses the CD-ROM elaborated to provide a continuous professional formation and a practical guidance on the implementation and operation of routine quality assurance (QA) programme for medical physicists, regulator authorities and for those personnel concerned with the daily provision of diagnostic radiology services. The CD-ROM contains topics on the basic concepts of QA in radiodiagnostic, and it also allows the user to visualise effects on the variation of technical parameters (tube potential (kV) and current (mA), filtration) in the quality of the image. This possibility will contribute to the better understanding of the phenomena associated with the quality of the image. Besides, the program contains the procedures for the execution of the tests of the equipment and the route of implantation of program of quality assurance. It is interactive with the user, it fills a gap in the medical physics area and it allows the student's continuous formation because it assists the beginner, with the basic concepts, and the professional, with the aid in the implantation of the program of QA. The presentation is in the Portuguese language. (author)

經由校園網路存取圖書館光碟資料庫之研究 Studies on Multiuser Access Library CD-ROM Database via Campus Network

Directory of Open Access Journals (Sweden)

Ruey-shun Chen

1992-06-01

Full Text Available 無Library CD-ROM with its enormous storage, retrieval capabilities and reasonable price. It has been gradually replacing some of its printed counterpart. But one of the greatest limitation on the use of stand-alone CD-ROM workstation is that only one user can access the CD-ROM database at a time. This paper is proposed a new method to solve this problem. The method use personal computer via standard network system Ethernet high speed fiber network FADDY and standard protocol TCP/IP can access library CD-ROM database and perform a practical CD-ROM campus network system. Its advantage reduce redundant CD-ROM purchase fee and reduce damage by handed in and out and allows multiuser to access the same CD-ROM disc simultaneously.

Factors Affecting Pre-Service TESOL Teachers' Attitudes towards Using CD-ROM Dictionary

Science.gov (United States)

Issa, Jinan Hatem; Jamil, Hazri

2011-01-01

Rapid technological advances in communication technologies and computational power are altering the nature of knowledge, skills, talents and the know-how of individuals. A CD-ROM dictionary is an interesting and effective teaching tool, which captures pre-service teachers' interest and does much more than just translates especially with the…

Mars Navigator: An Interactive Multimedia Program about Mars, Aerospace Engineering, Astronomy, and the JPL Mars Missions. [CD-ROM

Science.gov (United States)

Gramoll, Kurt

This CD-ROM introduces basic astronomy and aerospace engineering by examining the Jet Propulsion Laboratory's (JPL) Mars Pathfinder and Mars Global Surveyor missions to Mars. It contains numerous animations and narrations in addition to detailed graphics and text. Six interactive laboratories are included to help understand topics such as the…

Guide Structures in CD-ROM Dictionaries, with Specific Reference to the EWED and the ELHAT

Directory of Open Access Journals (Sweden)

Philip Louw

2011-10-01

Full Text Available

macro- and microstructural information. In order to evaluate the methods which lexicographers employ to improve dictionary accessibility, the concept of guide structures was introduced by Hausmann and Wiegand (1989. Since the appearance of that article, various academics have written articles and read papers on guide structures in print dictionaries, but few studies have focussed on the tremendous potential of guide structures in electronic dictionaries. In this article it will be shown that electronic dictionaries add dimensions to the implementation of guide structures not possible in print versions. The role of two of the guide structures in the transfer of infonnation in CD-ROM dictionaries will be discussed. The access and mediostructures of the Microsoft Encarta World English Dictionary and the Elektroniese Handwoordeboek van die Afrikaanse Taal will be analysed and critically evaluated to illustrate the advantages of electronic dictionaries over print dictionaries and the urgent need for metalexicographical discussion of this publication medium.

Keywords: ACCESS STRUCTURE; ACTIVE CROSS-REFERENCES; CD-ROM DICTIONARY; DICTIONARY ACCESSIBILITY; ENCYCLOPAEDIC DICTIONARY; GUIDE STRUCTURES; INNER ACCESS STRUCTURE; INNER SEARCH PATH; INTERNET; MEDIOSTRUCTURE; MULTIMEDIA; OUTER ACCESS STRUCTURE; OUTER SEARCH PATH; PASSIVE CROSSREFERENCING; USER-FRIENDLINESS

Opsomming: Gidsstrukture in CD-ROM-woordeboeke, met spesifieke verwysingna EWED en ELHA T. Die sukses van modeme woordeboeke hang grootliles af vandie toeganklikheid van hulle makro- en mikrostrukturele inligting. Hausmann en Wiegand (1989het die konsep van gidsstrukture ingevoer om die metodes te evalueer wat leksikograwe gebruikom woordeboektoeganklikheid Ie verbeter. Sedert hierdie artikel verskyn het, het verskeie akademic:i artikels gepubliseer en referate gelewer oor gidsstrukture in gedrukte woordeboeke, maarmin studies het gefokus op die geweldige potensiaal van

Occupational Analysis Products: Space Systems Operations - AFSC 1C6X1 (CD-ROM)

National Research Council Canada - National Science Library

Boerstler, Robert E

2004-01-01

...: 1 CD-ROM; 4 3/4 in.; 30.4 MB. SYSTEMS DETAIL NOTE: ABSTRACT: The Space Systems Operations career ladder was surveyed to obtain current task and equipment data for use in evaluating current training programs...

Year 5 Pupils Reading an "Interactive Storybook" on CD-ROM: Losing the Plot?

Science.gov (United States)

Trushell, John; Burrell, Clare; Maitland, Amanda

2001-01-01

This study examined whether small groups of grade 5 students in a London primary school, without teacher supervision, progressed linearly through an interactive storybook on CD-ROM, and whether such diversions as cued animations affected pupil comprehension. Results showed students' recall of the storyline was poor. (Author/LRW)

Helping Family Physicians Improve Their Cardiac Auscultation Skills with an Interactive CD-ROM.

Science.gov (United States)

Roy, Douglas; Sargeant, Joan; Gray, Jean; Hoyt, Brian; Allen, Michael; Fleming, Michael

2002-01-01

Physicians (n=42) studied cardiac auscultation using a 15-hour CD-ROM program. Nine months later, 21 who completed a posttest showed significant improvement in identifying heart sounds. CDs were valued for opportunities to review material at an individual pace. Lack of computer skills hindered use. (Contains 26 references.) (SK)

Whole Language, Computers and CD-ROM Technology: A Kindergarten Unit on "Benjamin Bunny."

Science.gov (United States)

Balajthy, Ernest

A kindergarten teacher, two preservice teachers, and a college consultant on educational computer technology designed and developed a 10-day whole-language integrated unit on the theme of Beatrix Potter's "Benjamin Bunny." The project was designed as a demonstration of the potential of integrating the CD-ROM-based version of…

How To Use the SilverPlatter Software To Search the ERIC CD ROM.

Science.gov (United States)

Merrill, Paul F.

This manual provides detailed instructions for using SilverPlatter software to search the ERIC CD ROM (Compact Disk Read Only Memory), a large bibliographic database relating to education which contains reference information on numerous journal articles from over 750 journals cited in the "Current Index to Journals in Education" (CIJE),…

Occupational Analysis Products: Operations Management- AFSC 3E6X1 (CD-ROM)

Science.gov (United States)

computer laser optical disc (CD-ROM); 4 3/4 in.; 23.4 MB. SYSTEMS DETAIL NOTE: ABSTRACT: This is a report of an occupational survey of the Operations ... Management (AFSC 3E6X1, OSSN 2560, Feb 04) career ladder, conducted by the Occupational Analysis Flight, AFOMS. The OSR reports the findings of current

Review of The Earl of Abergavenny. Historical Record and Wreck Excavation CD-Rom

Directory of Open Access Journals (Sweden)

David Petts

2003-06-01

Full Text Available In early February 1805 a small fleet of East Indiamen accompanied by the frigate Weymouth set sail from Portsmouth heading first for Bengal and ultimately for China. However, barely had the voyage began when, following bad weather and confusion, one of the boats, the Earl of Abergavenny, struck the Shambles bank just off Portland Bill. Although the crew managed to free it, it was so badly damaged it sank while trying to make for the safety of Weymouth. Over 250 crew and passengers drowned. The wreck has until now been best known for causing the death of John Wordsworth, the ship's commander and brother of the poet William Wordsworth. This excellent CD report of archaeological investigations on the wreck site carried out since 1980 by the Weymouth Underwater Archaeological Group (WUAG brings us the full picture of the events leading up to the wreck, and a record of the remains found by the team of divers (Fig.1. The complex campaigns of diving have been carried out alongside extensive documentary and historical work. The huge amount of data created by this project has inevitably led to challenges for the WUAG regarding its publication (Cumming 2002. The decision to publish via a CD-ROM has allowed very large quantities of data and discussion to be published. The current version of the CD contains over 100,000 words of text, 1560 files and over 1000 illustrations (JPEGS. All for the grand price of 10 GBP. The volume can be browsed using a commercially available browser but is also supplied as compiled file using Web Compiler, which has the advantage of a search facility.

Evaluation of the use of CD-ROM upload into the PACS or institutional web server

NARCIS (Netherlands)

van Ooijen, P. M. A.; Roosjen, R.; de Blecourt, M. J.; van Dam, R.; Broekema, A.; Oudkerk, M.

2006-01-01

Purpose: Patient data are increasingly distributed between hospitals using CD-ROMs instead of actual films. This introduces problems because different viewers from different vendors are provided, and sometimes viewers are unusable because local software installation is not allowed. In 2004, we

DICOM storage into PACS of out-hospital CD-ROMs - a half year experience report

NARCIS (Netherlands)

van Ooijen, PMA; ten Bhomer, PJM; Blecourt, MJ; Roosjen, R; van Dam, R; Oudkerk, A; Lemke, HU; Inamura, K; Doi, K; Vannier, MW; Farman, AG

2005-01-01

With the advance of digitalization of radiology departments, the interchange of data between institutions is shifting towards shipment of CD-ROMs instead of physical film. Although this is a positive change in terms of costs, it also has its downsides. One of the main problems is how to integrate

Experience teaching CD-ROM-based course on CANDU nuclear-power-plant systems and operation

International Nuclear Information System (INIS)

Rouben, Benjamin

2008-01-01

This paper presents personal experience garnered from teaching a CD-ROM-based course on CANDU Power-Plant Systems and Operation. This course was originally developed by Prof. G.T. Bereznai as research in distance-learning techniques when he was directing the Thai-Canadian Human Resources Development Project at Chulalongkorn University in Bangkok. The course has been offered in a number of universities, including McMaster University and the University of Ontario Institute of Technology. All the course material, including lectures, assignments, and a simulator, is provided on a CD-ROM. Lectures include a spoken soundtrack covering the material. The class often includes both undergraduate and graduate students. I found that most students appreciate having the material on electronic format, which they can view and review at will and on their own time. Students find this course quite intensive - it covers all major systems in the CANDU reactor and power plant in detail. A very important component of the course is the simulator, which teaches students how systems operate in normal operation, in power manoeuvres, and during process-system malfunctions. Effort in absorbing the material and performing assignments can often exceed 10 hours per week. Some of the simulator assignments involve tricky manoeuvres, requiring several tries to achieve the expected result. Some assignments may take several hours, especially if the manoeuvres requiring repetition take 30 minutes or more in real time. I found that some instruction in the basic theory of reactor physics and systems is appreciated by students. A few possible enhancements to the simulator model were identified. Graduate students taking the course are required to do an additional project; I assigned an investigation of the effects of xenon-concentration changes during 1 week of load cycling. In summary, this course provides to students the opportunity to learn a great deal about the workings of CANDU-plant systems. (author)

Recovery of Data from the Narragansett Bay Project, 1985-1992: User's Manual and CD-ROM

Science.gov (United States)

Data from the 1985-1992 era of the Narragansett Bay Project, an estuary of the National Estuary Program, were recovered from numerous storage media, updated to modern software, and burned to CD-ROM. The data will be used by, among others, EPA researchers working on long-term tren...

Exploiting the Potential of CD-ROM Databases: Staff Induction at the University of East Anglia.

Science.gov (United States)

Guillot, Marie-Noelle; Kenning, Marie-Madeleine

1995-01-01

Overviews a project exploring the possibility of using CD-ROM applications and the design of exploratory didactic materials to introduce academic staff to the field of computer-assisted instruction. The project heightened the staff's awareness of electronic resources and their potential as research, teaching, and learning aids, with particular…

Flight Experiments for Hypersonic Vehicle Development (Experimentations envol pour le developpement d'un vehicule hypersonique) (CD-ROM)

National Research Council Canada - National Science Library

2007-01-01

...: 1 CD-ROM; 4 3/4 in.; 124 MB. ABSTRACT: This RTO-AVT/VKI Lecture Series brought together specialists from Europe, USA, and Russia to discuss flight experiments that pertain to the development of hypersonic vehicles...

The Impact of Animation in CD-ROM Books on Students' Reading Behaviors and Comprehension.

Science.gov (United States)

Okolo, Cindy; Hayes, Renee

This study evaluated the use of children's literature presented via one of three conditions: an adult reading a book to the child; the child reading a CD-ROM version of a book on the computer but without animation; and the child reading the book on the computer with high levels of animation. The study, in one primary grade classroom, involved 10…

[Medical knowledge in immunological security of red blood cells transfusion in Tunisia: evaluation of a CD-ROM of auto-learning].

Science.gov (United States)

Ben Salah, N; El Borgi, W; Aounallah Skhiri, H; Ben Lakhal, F; Mouelhi, H; Zoueri, B; Gouider, E; Hafsia, R

2013-09-01

In Tunisia, red blood cells (RBC) transfusion joins in a statutory frame but remains subject to failures because of the misunderstanding of legislation and regulations. Our purpose is to estimate the knowledge of the medical staff in the immunological safety of RBC transfusion before and after reading an auto-education CD-ROM. It is a study of evaluation of an intervention. Eighty physicians participated to the study. The evaluation was done using an anonymous questionnaire, containing seven questions with multiple choices (QMC) relating to several items. The rate of good answers (RGA) calculated by questions and by items took into account the impact of the CD-ROM on the improvement of the answers after reading. The global average mark is 2.9/7. The RGA to questions varies from 22.5 % to 76.3%. All participants answered correctly to more than 50% of all items. Two answered correctly to all items. Among the participants, 31.3% answered to all "important" items, concerning ABO blood groups compatibility and ultimate bedside test. The rate of participation to the final evaluation was 83%. The impact of the CD-ROM was important and statistically significant. In the final evaluation, the global mark raised from 2.9 to 5.8/7, 31.5% (vs 2%) answered correctly all the questions and 95.5% (vs 31.3%) answered correctly all "important" items. This study revealed a misunderstanding of the doctors in immunological safety of RBC transfusions. Auto-teaching by CD-ROM was efficient. An improvement of the knowledge by continuous training is necessary in our country. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Investigating the use of CD-Rom CBT for bulimia nervosa and binge eating disorder in an NHS adult outpatient eating disorders service.

Science.gov (United States)

Graham, Lisa; Walton, Mark

2011-07-01

Many patients who experience bulimia nervosa (BN) and binge eating disorder (BED) find it hard to access evidence-based treatments. Rates of failure to enter outpatient services following initial assessment are high, as are dropout rates from specialist outpatient eating disorders services. To offer CD-Rom CBT, a cognitive-behavioural multi-media supported self-help treatment, in a locality-based outpatient NHS Eating Disorders Service to patients who have binge eating disorder and bulimia nervosa. Patients referred to a catchment-based NHS outpatient eating disorders service who were assessed and had an eating disorder with a binge-eating component were offered CD-Rom based CBT (Overcoming Bulimia) whilst on the waiting list for individual CBT. Forty patients completed the 8 sessions and attended the evaluation appointment (13 had BN, 27 had BED). For both groups, there were significant improvements in well-being and functioning, as well as significant reductions in problems and risk. There was also a significant reduction on the "Bulimic Subscale" of the EDI. These results were comparable with the original study findings (Schmidt, Treasure and Williams, 2001). Dropouts from the CD-Rom reflected rates common to other EDS treatments suggesting that CD-Rom did not directly impact upon service dropout rates. Computer assisted CBT for Eating Disorders offers a promising, feasible and acceptable first step for patients who have bulimia nervosa or binge eating disorder and access treatment from specialist eating disorders services.

Defense Information for All: DTIC 2007 Conference Held in Alexandria, Virginia on March 26-28, 2007 (CD-ROM)

National Research Council Canada - National Science Library

2007-01-01

...: 1 CD-ROM; 4 3/4 in.; 88.6 MB. ABSTRACT: The conference will bring together information professionals from the science, technology, research and development, and acquisition communities who create, disseminate and use DoD scientific...

Car Builder: Design, Construct and Test Your Own Cars. School Version with Lesson Plans. [CD-ROM].

Science.gov (United States)

Highsmith, Joni Bitman

Car Builder is a scientific CD-ROM-based simulation program that lets students design, construct, modify, test, and compare their own cars. Students can design sedans, four-wheel-drive vehicles, vans, sport cars, and hot rods. They may select for aerodynamics, power, and racing ability, or economic and fuel efficiency. It is a program that teaches…

Adventures in Evaluation: Reviewing a CD-ROM Based Adventure Game Designed for Young People Recovering from Psychosis

Science.gov (United States)

Shrimpton, Bradley; Hurworth, Rosalind

2005-01-01

Recently the Centre for Program Evaluation (CPE) at the University of Melbourne was approached by a mental health agency to undertake the unique and challenging task of evaluating a prototype CD-ROM based adventure game designed for young people recovering from psychosis. This unusual and inventive game, titled Pogo's Pledge, used…

Processing of Irradiated Graphite to Meet Acceptance Criteria for Waste Disposal. Results of a Coordinated Research Project. Companion CD-ROM

International Nuclear Information System (INIS)

2016-05-01

Graphite is widely used in the nuclear industry and in research facilities and this has led to increasing amounts of irradiated graphite residing in temporary storage facilities pending disposal. This publication arises from a coordinated research project (CRP) on the processing of irradiated graphite to meet acceptance criteria for waste disposal. It presents the findings of the CRP, the general conclusions and recommendations. The topics covered include, graphite management issues, characterization of irradiated graphite, processing and treatment, immobilization and disposal. Included on the attached CD-ROM are formal reports from the participants

Technical and Scientific Support Organizations Providing Support to Regulatory Functions. Companion CD-ROM

International Nuclear Information System (INIS)

2018-01-01

This publication introduces the general principles underlying the provision of technical and scientific support to a regulatory body and the characteristics of organizations providing such support. It describes the services provided to support regulatory functions as well as the associated activities and processes to maintain the needed level of expertise, state of the art tools and equipment. The publication is intended for use primarily by organizations that provide technical and scientific support in the field of nuclear and radiation safety. This also includes organizations that acquire such support, and regulatory bodies and governments, as they make decisions on the model of technical and scientific support to be developed at the national level, for example in the case of a country embarking on the development of a nuclear power programme. It is the first IAEA publication dedicated to the specific practices and challenges to be met by the technical and scientific support organizations. This CD-ROM includes the annexes to the printed publication of examples of TSOs and their interactions with key stakeholders.

Computer Based Radiation Protection- A New Cd-Rom

International Nuclear Information System (INIS)

Geringer, T.; Bammer, M.; Ablber, M.

2004-01-01

Within the next few years, there'll be a lot of new challenges required from radiation protection. According to EU regulation[1] and the new austrian radiation protection law [2] regular additional training are requested. Patients protection in diagnostic and therapeutic usage of ionising radiation gains also more and more importance.[3] Not really surprisingly, the general population is definitely highly aware of the risks coming with the usage of radionuclides and x-rays in medicine. Furthermore, the nuclear power plant in Temelin, near the austrian border initiated a lively discussion about risks, necessity and use of ionising radiation in medicine and industry. It turned out to be a really hard job handling these topics in public. A brilliant didactics based on independent information and viewpoints was required. ARC Seibersdorf Research GmbH, represented by the department of medical technical applications and the radiation protection academy, developed an interactive CD-ROM covering several applications: Basics on radiation protection for medical and technical personnel ; preparation for a radiation protection training. Repetition of the main topics for graduates of a radiation protection training. Basics on radiation protection and emergency management for medical staff as well as for the general public. (Author)

Nuclides 2000: an electronic chart of the nuclides on CD-ROM

International Nuclear Information System (INIS)

Magill, J.

2000-01-01

The 'Nuclides 2000' software package is an electronic chart of the nuclides, available on CD-ROM for Microsoft Windows operating systems, which offers extensive basic information on physics and radiology of the familiar nuclides. Moreover, 'Nuclides 2000' contains codes for a number of applications which allow the required data to be computed quickly and reliably by means of interactive user guidance. The data and codes are supplemented by information in the format of contributions on the history of radioactivity and radiochemistry, and on subjects of interest in physics, such as C-14 dating and the generation of Ti-44 in a supernova, and by a link collection of Internet addresses. As a detailed database, 'Nuclides 2000' can be used for teaching, research, and for practical applications. (orig.) [de

History, Development and Future of TRIGA Research Reactors. Companion CD-ROM

International Nuclear Information System (INIS)

2016-01-01

Due to its particular fuel design and resulting enhanced inherent safety features, TRIGA reactors (Training, Research, Isotopes, General Atomics) constitute a ‘class of their own’ among the large variety of research reactors built world-wide. This publication summarizes in a single document the information on the past and present of TRIGA research reactors and presents an outlook in view of potential issues to be solved by TRIGA operating organizations in the near future. It covers the historical development and basic TRIGA characteristics, followed by utilization, fuel conversion and ageing management of TRIGA research reactors. It continues with issues and challenges, introduction to the global TRIGA research reactor network and concludes with future perspectives. This CD-ROM illustrates the historical developments of TRIGA research reactors through individual facility examples and experiences

Ionospheric Electron/Ion Densities Temperatures on CD-ROM and WWW

Science.gov (United States)

Bilitza, Dieter; Papitashvili, Natasha; Schar, Bill; Grebowsky, Joseph

2002-01-01

As part of this project a large volume of ionospheric satellite insitu data from the sixties, seventies and early eighties were made accessible online in ASCII format for public use. This includes 14 data sets from the BE-B, Alouette 2, DME-A, AE-B, ISIS-1, ISIS-2, OGO-6, DE-2, AEROS-A, AE-C, AE-D, AE-E, and Hinotori satellites. The original data existed in various machine-specific, highly compressed, binary encoding on 7-, or 9-track magnetic tapes. The data were decoded and converted to a common ASCII data format, solar and magnetic indices were added, and some quality control measures were taken. The original intent of producing CD-ROMs with these data was overtaken by the rapid development of the Internet. Most users now prefer to obtain the data directly online and greatly value WWW-interfaces to browse, plot and subset the data. Accordingly the data were made available online on the anonymous ftp site of NASA's National Space Science Data Center (NSSDC) at ftp://nssdcftp.gsfc.nasa.gov/spacecraft data/ and on NSSDC's ATMOWeb (http://nssdc.gsfc.nasa.gov/atmoweb/), a WWW-interface for plotting, subsetting, and downloading the data. Several new features were implemented into ATMOWeb as part of this project including a filtering and scatter plot capability. The availability of this new database and WWW system was announced through several electronic mailer (AGU, CEDAR, IRI, etc) and through talks and posters during scientific meetings.

CD-ROM nutrient analysis database assists self-monitoring behavior of active duty Air Force personnel receiving nutrition counseling for weight loss.

Science.gov (United States)

Heetderks-Cox, M J; Alford, B B; Bednar, C M; Heiss, C J; Tauai, L A; Edgren, K K

2001-09-01

This study observed the effect of using a computerized vs manual method of self-monitoring among Air Force personnel receiving nutrition counseling for weight loss. Subjects who enrolled during the first 2 weeks of the 4-week recruitment period completed food records for 6 weeks using a CD-ROM nutrient database (intervention group) whereas those who enrolled during the last 2 weeks used a food record booklet (comparison group). Of the 42 subjects (n = 23 intervention group and n = 19 comparison group), only 113 intervention and 11 comparison group subjects (57% of study enrollees) submitted at least 1 food record during the study and were included in the analysis, which included review of pre- and poststudy questionnaires, food records, and focus group data. There were no significant differences between the number of days per week documented or average number of items recorded daily. All 9 intervention as compared to 2 comparison group subjects who completed a poststudy questionnaire searched for lower-energy and lower-fat items and reported changing their dietary intake as a result. All intervention group subjects who participated in a focus group (n=6) had favorable comments about using the CD-ROM for monitoring and changing eating habits, indicating that it is a beneficial self-monitoring tool. Participants enjoyed the immediate dietary feedback, and computerized food records may be easier to interpret by nutrition counselors. A number of computerized nutrient databases are available to assist patients and consumers in managing nutritional concerns.

Data base management system and display software for the National Geophysical Data Center geomagnetic CD-ROM's

Science.gov (United States)

Papitashvili, N. E.; Papitashvili, V. O.; Allen, J. H.; Morris, L. D.

1995-01-01

The National Geophysical Data Center has the largest collection of geomagnetic data from the worldwide network of magnetic observatories. The data base management system and retrieval/display software have been developed for the archived geomagnetic data (annual means, monthly, daily, hourly, and 1-minute values) and placed on the center's CD-ROM's to provide users with 'user-oriented' and 'user-friendly' support. This system is described in this paper with a brief outline of provided options.

Analysis of User Need with CD-ROM Databases: A Case Study Based on Work Sampling at One University Library.

Science.gov (United States)

Wells, Amy Tracy

Analysis of the needs of users of Compact Disk-Read Only Memory (CD-ROM) was performed at the Tampa campus of the University of South Florida. A review of the literature indicated that problems associated with selecting the appropriate database, searching, and requiring technical assistance were the probable areas of user need. The library has 17…

Volcanoes of México: An Interactive CD-ROM From the Smithsonian's Global Volcanism Program

Science.gov (United States)

Siebert, L.; Kimberly, P.; Calvin, C.; Luhr, J. F.; Kysar, G.

2002-12-01

The Smithsonian Institution's Global Volcanism Program is nearing completion of an interactive CD-ROM, the Volcanoes of México. This CD is the second in a series sponsored by the U.S. Department of Energy Office of Geothermal Technologies to collate Smithsonian data on Quaternary volcanism as a resource for the geothermal community. It also has utility for those concerned with volcanic hazard and risk mitgation as well as an educational tool for those interested in Mexican volcanism. We acknowledge the significant contributions of many Mexican volcanologists to the eruption reports, data, and images contained in this CD, in particular those contributions of the Centro Nacional de Prevencion de Desastres (CENAPRED), the Colima Volcano Observatory of the University of Colima, and the Universidad Nacional Autónoma de México (UNAM). The Volcanoes of México CD has a format similar to that of an earlier Smithsonian CD, the Volcanoes of Indonesia, but also shows Pleistocene volcanic centers and additional data on geothermal sites. A clickable map of México shows both Holocene and Pleistocene volcanic centers and provides access to individual pages on 67 volcanoes ranging from Cerro Prieto in Baja California to Tacaná on the Guatemalan border. These include geographic and geologic data on individual volcanoes (as well as a brief paragraph summarizing the geologic history) along with tabular eruption chronologies, eruptive characteristics, and eruptive volumes, when known. Volcano data are accessible from both geographical and alphabetical searches. A major component of the CD is more than 400 digitized images illustrating the morphology of volcanic centers and eruption processes and deposits, providing a dramatic visual primer to the country's volcanoes. Images of specific eruptions can be directly linked to from the eruption chronology tables. The Volcanoes of México CD includes monthly reports and associated figures and tables cataloging volcanic activity in M�

Effects of the CD-Rom Version of the "Self-Advocacy Strategy" on Quality of Contributions in IEP Meetings of High School Students with Intellectual Disability

Science.gov (United States)

Cease-Cook, Jennifer; Test, David W.; Scroggins, La' Shawndra

2013-01-01

This study used a multiple-probe across participants design to examine the effects of the CD-Rom version of the "Self-Advocacy Strategy" on quality of contributions in Individual Education Plan (IEP) meetings of five high school students with intellectual disability. Results indicated a functional relationship between using the CD-Rom…

Review of World of Money CD-ROM for PC/Mac [CD-ROM

Directory of Open Access Journals (Sweden)

Philip de Jersey

1998-12-01

Full Text Available Following on from the impressive development of the new HSBC Money Gallery in 1997, the British Museum has launched into the world of electronic publishing with the World of Money, an "interactive exploration of money worldwide from ancient times to the present day". Intended for ages ten to adult, the CD promises "a mine of information about the use, form, history and importance of money around the globe", and "fun and information for all the family". Reviewing in a Mac-unfriendly environment, I have been able to run the CD only on a PC. On a 166Mhz MMX with 32Mb RAM and a 12x CD it runs impressively quickly, with no more than two or three seconds of the "loading new page" display when switching between different parts of the program. Minimum requirements are listed as a 486 with 8Mb RAM, 40Mb free hard disk space, Windows 3.11 or Windows 95, 4x CD drive, 1Mb 256 colours graphics card, 16-bit Sound Blaster compatible sound card, and a VGA monitor. Minimum requirements for the Mac are listed as System 7, 603e processor, 16Mb RAM, 40MB free hard disk space, 6x CD drive, 1Mb video card and Apple monitor or Multisync with adaptor. The CD opens with an image of the British Museum portico, through which we are taken into the foyer, complete with the sound effects of massed ranks of tourists. We have four options available on a lectern, or by turning left, right or going upstairs: History of Money, Information Centre, Activities, and Options. Clicking on a large question mark brings up the Help screens (Figure 1.

Proceedings of the High Performance Embedded Computing Workshop (HPEC 2006) (10th). Held in Lexington, Massachusetts on September 19-21, 2006 (CD-ROM)

National Research Council Canada - National Science Library

Kepner, Jeremy

2007-01-01

...: 1 CD-ROM; 4 3/4 in.; 78.3 MB. ABSTRACT: The High-Performance Embedded Computing (HPEC) technical committee announced the tenth annual HPEC Workshop held in September 2006 at MIT Lincoln Laboratory in Lexington, MA...

School Survey on Crime and Safety (SSOCS) 2000 Public-Use Data Files, User's Manual, and Detailed Data Documentation. [CD-ROM].

Science.gov (United States)

National Center for Education Statistics (ED), Washington, DC.

This CD-ROM contains the raw, public-use data from the 2000 School Survey on Crime and Safety (SSOCS) along with a User's Manual and Detailed Data Documentation. The data are provided in SAS, SPSS, STATA, and ASCII formats. The User's Manual and the Detailed Data Documentation are provided as .pdf files. (Author)

Quality Management Audits in Nuclear Medicine Practices. 2. Ed. Companion CD-ROM

International Nuclear Information System (INIS)

2015-01-01

Quality management systems are essential and should be maintained with the intent to continuously improve effectiveness and efficiency, enabling nuclear medicine to achieve the expectations of its quality policy, satisfy its customers and improve professionalism. The quality management (QM) audit methodology in nuclear medicine practice, introduced in this publication, is designed to be applied to a variety of economic circumstances. A key outcome is a culture of reviewing all processes of the clinical service for continuous improvement in nuclear medicine practice. Regular quality audits and assessments are vital for modern nuclear medicine services. More importantly, the entire QM and audit process has to be systematic, patient oriented and outcome based. The management of services should also take into account the diversity of nuclear medicine services around the world and multidisciplinary contributions. The latter include clinical, technical, radiopharmaceutical, medical physics and radiation safety procedures. This companion CD-ROM is attached to the printed STI/PUB/1683 and contains the full-text of STI/PUB/1683 as well as checklists in PDF and Excel format and a table with the contents of a standardized audit report

The Lunar Source Disk: Old Lunar Datasets on a New CD-ROM

Science.gov (United States)

Hiesinger, H.

1998-01-01

A compilation of previously published datasets on CD-ROM is presented. This Lunar Source Disk is intended to be a first step in the improvement/expansion of the Lunar Consortium Disk, in order to create an "image-cube"-like data pool that can be easily accessed and might be useful for a variety of future lunar investigations. All datasets were transformed to a standard map projection that allows direct comparison of different types of information on a pixel-by pixel basis. Lunar observations have a long history and have been important to mankind for centuries, notably since the work of Plutarch and Galileo. As a consequence of centuries of lunar investigations, knowledge of the characteristics and properties of the Moon has accumulated over time. However, a side effect of this accumulation is that it has become more and more complicated for scientists to review all the datasets obtained through different techniques, to interpret them properly, to recognize their weaknesses and strengths in detail, and to combine them synoptically in geologic interpretations. Such synoptic geologic interpretations are crucial for the study of planetary bodies through remote-sensing data in order to avoid misinterpretation. In addition, many of the modem datasets, derived from Earth-based telescopes as well as from spacecraft missions, are acquired at different geometric and radiometric conditions. These differences make it challenging to compare or combine datasets directly or to extract information from different datasets on a pixel-by-pixel basis. Also, as there is no convention for the presentation of lunar datasets, different authors choose different map projections, depending on the location of the investigated areas and their personal interests. Insufficient or incomplete information on the map parameters used by different authors further complicates the reprojection of these datasets to a standard geometry. The goal of our efforts was to transfer previously published lunar

Effects of Contract Delivery Method on the LEED(trademark) Score of U.S. Navy Military Construction Projects (Fiscal Years 2004-2006) (CD-ROM)

National Research Council Canada - National Science Library

Carpenter, Deanna S

2005-01-01

...: 1 CD-ROM; 4 3/4 in.; 484 KB. ABSTRACT: This research study focused on determining the effects that the two major contract delivery methods had on the LEED score of projects over the design and construction time horizon...

NODC Standard Product: Coastal Change Analysis Program (C-CAP) Chesapeake Bay Region Data from 1984 to 1989 on CD-ROM (NODC Accession 9200303)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The data set on this CD-ROM shows changes in land cover for the Chesapeake Bay region over the 5-year interval from 1984 to 1988-89. The data set was produced...

The use of CD-ROMs for storage and document delivery at the British Library Document Supply Centre

International Nuclear Information System (INIS)

Bradbury, D.

1990-05-01

The British Library Document Supply Centre (BLDSC) has been in the forefront of international document delivery for 20 years. During the last 5 years it has been very actively involved in the ADONIS Project, through which the full text of some 200 journals in the life sciences have been stored, accessed, and delivered through the medium of CD-ROM. The BLDSC's involvement in this project is described and indications of the lessons learned and of the implications for international document delivery systems in the future are given. (author)

The use of CD-ROMs for storage and document delivery at the British Library Document Supply Centre

Energy Technology Data Exchange (ETDEWEB)

Bradbury, D [British Library Document Supply Centre, Boston SPA (United Kingdom)

1990-05-01

The British Library Document Supply Centre (BLDSC) has been in the forefront of international document delivery for 20 years. During the last 5 years it has been very actively involved in the ADONIS Project, through which the full text of some 200 journals in the life sciences have been stored, accessed, and delivered through the medium of CD-ROM. The BLDSC`s involvement in this project is described and indications of the lessons learned and of the implications for international document delivery systems in the future are given. (author).

Students' and teachers' perceptions of motivation and learning through the use in schools of multimedia encyclopaedias on CD-ROM

OpenAIRE

Wishart , Jocelyn

2000-01-01

This article is the result of interviews with teachers, students, and school librarians in eight UK secondary schools regarding their use of multimedia encyclopaedias on CD-ROM. It focuses on a content analysis of their comments on how having access to multimedia encyclopaedias changes the way students work and learn in school, how they perceive it enhances their learning, and how it hinders it. Teachers reported that they used multimedia encyclopaedias as an additional information resource, ...

The Virtual 3D Reconstruction of the East Pediment of the Temple of Zeus at Olympia – Presentation of an Interactive CD-ROM

Directory of Open Access Journals (Sweden)

András PATAY-HORVÁTH Patay-Horváth

2011-12-01

Full Text Available The paper gives an overview of a two-years project concerning a major monument of ancient Greek art and presents the interactive, bilingual (English/Hungarian CD-ROM, which is intended to summarize and visualize its final results. The presented project approaches a century-old controversy in a new way by producing a virtual 3D reconstruction of a monumental marble group. Digital models of the statues were produced by scanning the original fragments and by reconstructing them virtually. The virtual model of the pediment surrounding the sculptures was prepared on the basis of the latest architectural studies and afterwards the reconstructed models were inserted in this frame, in order to test the technical feasibility and aesthetic effects the four possible arrangements. The resulting models enable easy and very instructive experimentation, which would be otherwise impossible with the originals and/or very expensive and not very practicable with traditional tools (e.g. real-size plaster models. The complete model can effectively be used to verify the results of earlier or more recent reconstructions presented only in simple drawings. In addition, the 3D models of the individual fragments can be used for further research and for visualization.  The documentary CD-ROM presenting the full background, the methods and the conclusions of the project contains beside a comprehensive text various kinds of supporting documents (images, 3D models, papers, broadcasts, audiovisual material. It is addressed to a mixed audience: a picture gallery, a short documentary movie some other attachments including a selected bibliography is intended for the general public, but scholarly publications, presentations on related problems are also included for specialists interested in certain details.

Diffusivity database (DDB) system for major rocks (Version of 2006/specification and CD-ROM)

International Nuclear Information System (INIS)

Tochigi, Yoshikatsu; Sasamoto, Hirosi; Shibata, Masahiro; Sato, Haruo; Yui, Mikazu

2006-03-01

The development of the database system has been started to manage with the generally used. The database system has been constructed based on datasheets of the effective diffusion coefficient of the nuclides in the rock matrix in order to be applied on the 'H12: Project to Establish the Scientific and Technical Basis for HLW Disposal in Japan'. In this document, the examination and expansion of the datasheet structure and the process of construction of the database system and conversion of all data existing on datasheets are described. As the first step of the development of the database, this database system and its data will continue to be updated and the interface will be revised to improve the availability. The developed database system is attached on the CD-ROM as the file format of Microsoft Access. (author)

On-line vs DC-ROM delivery of information

NARCIS (Netherlands)

Waaijers, L.

1992-01-01

Considers the use of new technologies in library information delivery systems. Discusses the virtues of paper, CD-ROM, and online media in terms of accessibility, timeliness, compactness, searchability, preservability, authenticity, and appearance, as well as end user benefit. Surmises that

Deutsche Literatur von Frauen – Jetzt auch digital! Literature by German Women—Now on CD!

Directory of Open Access Journals (Sweden)

Corinna Heipcke

2002-07-01

Full Text Available Die Digitale Bibliothek hat eine CD-Rom ediert, auf der ein Querschnitt durch die Werke von Autorinnen aus vier Jahrhunderten enthalten ist. Die Volltexte sind integriert in ein Bearbeitungsprogramm, das quellentreues Zitieren und Volltextrecherchen ermöglicht. Damit ist ein ausgesprochen praktisches Hilfsmittel für Germanistinnen und Germanisten entstanden. An ihre Grenzen gelangt die Sammlung allerdings bei der nicht unproblematischen Textauswahl.The editors of the Digital Library have tackled the task of creating a library which enables one to find any work that one may be interested in looking up or reading. Five years ago, a CD Rom entitled German Literature from Lessing to Kafka which present the complete works of select authors together with a programme that assists the user in better understanding their works. In so doing, however, women were almost completely omitted, as the entire CD only featured the works of four women authors. In order to overcome this shortcoming, Mark Lehmstedt edited the above-mentioned CD which contains the select works of 62 women authors from the baroque period to the Weimar Republic. Their works are accompanied by the latest software version of the Digital Library.

Method for a dummy CD mirror server based on NAS

Science.gov (United States)

Tang, Muna; Pei, Jing

2002-09-01

With the development of computer network, information sharing is becoming the necessity in human life. The rapid development of CD-ROM and CD-ROM driver techniques makes it possible to issue large database online. After comparing many designs of dummy CD mirror database, which are the embodiment of a main product in CD-ROM database now and in near future, we proposed and realized a new PC based scheme. Our system has the following merits, such as, supporting all kinds of CD format; supporting many network protocol; the independence of mirror network server and the main server; low price, super large capacity, without the need of any special hardware. Preliminarily experiments have verified the validity of the proposed scheme. Encouraged by the promising application future, we are now preparing to put it into market. This paper discusses the design and implement of the CD-ROM server detailedly.

NODC Standard Product: Atlas of surface marine data 1994 (9 disc set) (NCEI Accession 0101474)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — A set of 9 CD-ROMs were produced to accompany the analog publication Atlas of Surface Marine Data, 1994. Each CD-ROM contains monthly mean objectively analyzed...

Meteonorm. Global meteorological database for solar energy and applied climatology. Version 4.0: edition 2000. Software and data on CD-ROM

International Nuclear Information System (INIS)

1999-01-01

This is a comprehensive meteorological planning tool for system design, targeted at engineers, architects, teachers, planners and anyone interested in solar energy and climatology. METEONORM includes data from 2400 meteorological stations worldwide. Version V4.0 is based on over 15 years in the development of meteorological databases for energy. It may be used for solar applications at any desired location in the world, as an interpolation model of solar radiation and additional parameters for any site in the world is included. Also, with up-to-date algorithms, solar radiation incident on surfaces of arbitrary orientation may be calculated at the touch of a button. The local skyline profile may be specified. Five languages are supported: English, French, German, Italian, Spanish. Sites may be selected on map by means of a graphical interface. User data may be imported. 16 different output formats are available. Data, programme, manual, maps and illustrations are incorporated on the CD-ROM which is available for sale

SOFTWARE REVIEW: Multimedia Motion II. CD-ROM and Teacher's Guide

Science.gov (United States)

Scaife, Jon A.

2000-05-01

expect. This is an issue that is in the teacher's hands; the package is flexible enough to accommodate a wide range of learning aims. Audio clips are brief and to the point, with both female and male speakers. The commentary goes beyond the descriptive, raising interesting questions and issues and setting challenges for the user. The optional screen text is pitched at A-level. Video clips can be viewed at full screen, which is a big improvement over the first edition. There are some new clips and a few omissions from the first edition; further CDs of movie data are planned. Clips may be played forwards or backwards at various speeds using a scroll bar. This allows close control and analysis, which is useful for critical events in which changes are rapid, such as collisions. Printing of data and graphs is straightforward and the results are clear. Unlike the first edition, Multimedia Motion II only gives direct support to graphs with time as the abscissa. For graphs such as v(x) versus v(y), however, it is a simple matter to save the data directly into Excel or another spreadsheet. I encountered only one snag in using the CD: if I forgot to save my data before moving to a new clip I could not recover it. This failing could be mine, but I did try hard. The Teacher's Guide contains photocopiable worksheets and detailed discussion and graphs of the video clips. For each clip there is a section of `useful data and formulae'. The guide is not a necessity for using the CD-ROM but it would be a very handy A-level teaching resource, allowing the option of independent use by students. It is accompanied by a floppy disc containing sets of experimental data for the video clips, a useful option for quick demonstrations. In addition, the guide explains the interesting and creative option of making your own movie sequences from videotape, though access to a video card would be needed to do this. Imagine the motivational value of students recording themselves playing various sports, or

English grammar in use a self-study reference and practice book for intermediate learners of English : with answers and CD-ROM

CERN Document Server

Murphy, Raymond

2012-01-01

English Grammar in Use Fourth edition is an updated version of the world's best-selling grammar title. It has a fresh, appealing new design and clear layout, with revised and updated examples, but retains all the key features of clarity and accessibility that have made the book popular with millions of learners and teachers around the world. The CD-ROM contains lots of additional practice exercises to consolidate learning, ideal for self-study but also suitable for reinforcement work in the classroom. An online version and book without answers are available separately.

Genetics, mental illness, and complex disease: development and distribution of an interactive CD-ROM for genetic counselors. Final report for period 15 August 2000 - 31 December 2002

Energy Technology Data Exchange (ETDEWEB)

McInerney, Joseph D.

2003-03-31

"Genetics and Major Psychiatric Disorders: A Program for Genetic Counselors" provides an introduction to psychiatric genetics, with a focus on the genetics of common complex disease, for genetics professionals. The program is available as a CD-ROM and an online educational resource. The on-line version requires a direct internet connection. Each educational module begins with an interactive case study that raises significant issues addressed in each module. In addition, case studies provided throughout the educational materials support teaching of major concepts. Incorporated throughout the content are expert video clips, video clips from individuals affected by psychiatric illness, and optional "learn more" materials that offer greater depth about a particular topic. The structure of the CD-ROM permits self-navigation, but we have suggested a sequence that allows materials to build upon each other. At any point in the materials, users may pause and look up terms in the glossary or review the DSM-IV criteria for selected psychiatric disorders. A detailed site map is available for those who choose to self navigate through the content.

The development and pilot testing of a multimedia CD-ROM for diabetes education.

Science.gov (United States)

Castaldini, M; Saltmarch, M; Luck, S; Sucher, K

1998-01-01

The multimedia CD-ROM program, Take Charge of Diabetes, was found to be accurate, easy to use, and enjoyable by the clients and health professionals who completed the pilot study. Participants perceived an increase in knowledge after completing the five modules. Two of the participants verbally stated that the program clarified information for them and they wished they had had such a program when they were first diagnosed with diabetes. Further evaluation is needed to generalize the effect of the program on knowledge of diabetes because the pilot study was not designed to fully evaluate the effectiveness of the program on knowledge level or behavior change. Behavior change resulting in better control of blood sugar levels and hemoglobin A1c within normal range is the goal for diabetes education. The person who lives with diabetes must learn self-care methods. To accomplish that, the person must be able to comprehend the material presented. CAI programs provide an individualized, interactive, and interesting way to learn about diabetes and self-care, using visual effects and audio to support the written text. CAI can provide an element of excitement that is not available with other conventional methods. Providing prompt reinforcement of correct answers in quiz sections and including positive written messages can increase patients' self-confidence and self-esteem. Computer-assisted instruction is not intended to replace personal contact with physicians and diabetes educators, but rather complement this contact, reinforce learning, and possibly increase self-motivation to take charge of one's diabetes.

Earth in Space: A CD-ROM Version for Pre-College Teachers

Science.gov (United States)

Pedigo, P.

2003-12-01

Earth in Space, a magazine about the Earth and space sciences for pre-college science teachers, was published by AGU between 1987 and 2001 (9 issues each year). The goal of Earth in Space was to make research at the frontiers of the geosciences accessible to teachers and students and engage them in thinking about scientific careers. Each issue contained two or three recent research articles, rewritten for a high school level audience from the original version published in peer-reviewed AGU journals, which were supplemented with short news items and biographic information about the authors. As part of a 2003 summer internship with AGU, sponsored by the AGU Committee on Education and Human Resources (CEHR) and the American Institute of Physics, this collection of Earth in Space magazines was converted into an easily accessible electronic resource for K-12 teachers and students. Every issue was scanned into a PDF file. The entire collection of articles was cataloged in a database indexed to key topic terms (e.g., volcanoes, global climate change, space weather). A front-page was designed in order to facilitate rapid access to articles concerning specific topics within the Earth and space sciences of particular interest to high school students. A compact CD-ROM version of this resource will be distributed to science teachers at future meetings of the National Science Teachers Association and will be made available through AGU's Outreach and Research Support program.

Analysis of potential energy saving strategies in a Bangkok school building. With CD-ROM; Analyse von Energieeinsparpotentialen am Beispiel einer Schule in Bangkok

Energy Technology Data Exchange (ETDEWEB)

Temming, H.V.

2000-05-01

In cooperation with the Gesellschaft fuer technische Zusammenarbeit GTZ, a school building in Thailand was selected for an analysis of potentials for energy saving. The selected school was the New International School of Thailand (NIST) in Bangkok. Energy-relevant data were acquired by measurements, and solutions for more efficient energy supply were developed. Recommendations were made on this basis. This dissertation is also available on CD-ROM. [German] In Zusammenarbeit mit der Gesellschaft fuer technische Zusammenarbeit GTZ wurde als Beispielobjekt eine thailaendische Schule, die New International School of Thailand (NIST) in Bangkok ausgewaehlt. An diesem Objekt wurden die verschiedenen energetischen Messungen durchgefuehrt. Diese wurden bedarfsgerecht ausgewertet. Auf der Basis der Ergebnisse wurden Loesungsmoeglichkeiten fuer eine effizientere Energieversorgung der Schule konstruiert und diese Alternativen wie oben beschrieben bewertet, woraus sich entsprechende Empfehlungen ergeben. Der Aufbau dieser Arbeit stellt sich nun folgendermassen dar: Nachdem in einem ersten Schritt die fuer diesen Kontext wichtigsten Parameter Thailands und des Untersuchungsobjektes dargestellt werden, schliesst sich hieran die Vorstellung verschiedener technische Alternativen zur Erzeugung von Kaelte an, da hier ein Fokus fuer moegliche Energieeinsparungen gesetzt wird. Anschliessend werden einige in der Arbeit verwandte Berechnungsverfahren fuer energetische oder wirtschaftliche Zuammenhaenge sowie eine ausfuehrliche Beschreibung der energetischen 1st-Situation des Untersuchungsobjektes dargestellt. Darauf aufbauend folgt nun die Vorstellung der verschiedenen Energieeinsparpotentiale durch technische und verhaltensinduzierte Optimierungsmassnahmen. Diese Arbeit endet mit der Bewertung aller aufgedeckten Potentiale und einem Gesamtfazit aus der Untersuchung. (Diese Diplomarbeit liegt auch in Form einer CD-ROM vor.) (orig./AKF)

Applied Statistics: From Bivariate through Multivariate Techniques [with CD-ROM

Science.gov (United States)

Warner, Rebecca M.

2007-01-01

This book provides a clear introduction to widely used topics in bivariate and multivariate statistics, including multiple regression, discriminant analysis, MANOVA, factor analysis, and binary logistic regression. The approach is applied and does not require formal mathematics; equations are accompanied by verbal explanations. Students are asked…

The database system for the management of technical documentations of PWR fuel design project using CD-ROM

International Nuclear Information System (INIS)

Park, Bong Sik; Lee, Won Jae; Ryu, Jae Kwon; Jo, In Hang; Chang, Jong Hwa.

1996-12-01

In this report, the database system developed for the management of technical documentation of PWR fuel design project using CD-ROM (compact disk - read only memory) is described. The database system, KIRDOCM (KAERI Initial and Reload Fuel project technical documentation management), is developed and installed on PC using Visual Foxpro 3.0. Descriptions are focused on the user interface of the KIRDOCM. Introduction addresses the background and concept of the development. The main chapter describes the user requirements, the analysis of computing environment, the design of KIRDOCM, the implementation of the KIRDOCM, user's manual of KIRDOCM and the maintenance of the KIRDOCM for future improvement. The implementation of KIRDOCM system provides the efficiency in the management, maintenance and indexing of the technical documents. And, it is expected that KIRDOCM may be a good reference in applying Visual Foxpro for the development of information management system. (author). 2 tabs., 13 figs., 8 refs

Development of a CD-ROM on written language for the continuing education of elementary school teachers

Directory of Open Access Journals (Sweden)

Thaís dos Santos Gonçalves

2011-12-01

Full Text Available Distance education has emerged to minimize the anxiety of many professionals who need to update their knowledge, but do not have the time and opportunity to travel to educational centers. Objectives: To describe the development of a CD-ROM to provide distance continuing education to basic school teachers that addresses issues related to written language. Material and Methods: Previously, a script was developed with themes related to the acquisition and development of written language. Subsequently, a technical team transformed the texts in multimedia language. Results: The titles of each content area addressed are available on buttons and links. The files can be viewed in a linear sequence, allowing the teacher to start learning at the desired moment and go straight to the file that he or she wants to access. Videos that show practical applications of the concepts available in text are included. Conclusions: Brazil is a developing country. The use of technologies for education reduces cultural isolation among education professionals. It is necessary to focus on making teaching materials for distance education. In order to provide an effective learning environment, the learners reality should be considered. A multidisciplinary team should prepare the materials. The development of educational material for distance education on the acquisition and development of written language seems not only appropriate, but also warranted to provide professional growth opportunity for teachers who need time flexibility and/or live far away from academic centers.

Nuclear medicine installations supervisors interactive course (CD-ROM)

International Nuclear Information System (INIS)

Williart, A.; Shaw, M.; Tellez, M.

2000-01-01

The professionals who work as Nuclear Medicine Installations Supervisors need a suitable training. This training must be based on the guidelines of the C.S.N. (the Spanish Agency for Nuclear Safety). The traditional training courses must comply with a set of requirements, that not always is possible to get: They are given in a settled place. They are developed during a time, more or less lengthy. This time is pre-established. However, the persons willing to follow these courses have some difficulties with the place and the time. Many of them do not live near the places where the courses are given, in general in big cities, while there are Nuclear Medicine Installations scattered through all Spain. Moreover in some occasions they have not available time to attend the courses. Many times, faced with so many obstacles, the option is not to do the suitable training course. In order to solve this kind of problems we offer an Interactive Training Course (supported by CD-ROM). The course contents are based on Spanish Regulations and on the Safety Guide, established by C.S.N., for approval Radioactive Installations Supervisors Training Courses. This guide includes General Topics for Radioactive Installations and Specific Subjects for Nuclear Medicine. (General topics) Basic knowledge on the fundamental concepts on the action and nature of Ionizing Radiations, their risks and preventions. The ionizing radiations. Biological effects of ionizing radiations. Radiological protection. Legislation on radioactive installations. (Specific Subjects) Knowledge on the radiological risks associated to the proper techniques in the specific field of application. In our case the specific field is Nuclear Medicine Installations, where the radioactive sources are used for diagnostic or for therapy. Specific legal and administrative aspects. Non-encapsulated radioactive sources. Associated radiological risks to the use of non-encapsulated sources. Installations design. Operative procedures

The use of U.S. Geological Survey CD-ROM-based petroleum assessments in undergraduate geology laboratories

Science.gov (United States)

Eves, R.L.; Davis, L.E.; Dyman, T.S.; Takahashi, K.I.

2002-01-01

Domestic oil production is declining and United States reliance on imported oil is increasing. America will be faced with difficult decisions that address the strategic, economic, and political consequences of its energy resources shortage. The geologically literate under-graduate student needs to be aware of current and future United States energy issues. The U.S. Geological Survey periodically provides energy assessment data via digitally-formatted CD-ROM publications. These publications are free to the public, and are well suited for use in undergraduate geology curricula. The U.S. Geological Survey (USGS) 1995 National Assessment of United States Oil and Gas Resources (Digital Data Series or DDS-30) (Gautier and others, 1996) is an excellent resource for introducing students to the strategies of hydrocarbon exploration and for developing skills in problem-solving and evaluating real data. This paper introduces the reader to DDS-30, summarizes the essential terminology and methodology of hydrocarbon assessment, and offers examples of exercises or questions that might be used in the introductory classroom. The USGS contact point for obtaining DDS-30 and other digital assessment volumes is also provided. Completing the sample exercises in this report requires a copy of DDS-30.

Arkitekturen, Roms moderne bygningsværker

DEFF Research Database (Denmark)

Hansen, Peter Mandal

2012-01-01

Artikel om Roms moderne og nutidige arkitektur med beskrivelse og analyse af et udvalg af Roms markante bygningsværker.......Artikel om Roms moderne og nutidige arkitektur med beskrivelse og analyse af et udvalg af Roms markante bygningsværker....

Cern DD4424 ROM Diode Matrix

CERN Multimedia

A diode matrix is an extremely low-density form of read-only memory. It's one of the earliest forms of ROMs (dating back to the 1950s). Each bit in the ROM is represented by the presence or absence of one diode. The ROM is easily user-writable using a soldering iron and pair of wire cutters.This diode matrix board is a floppy disk boot ROM for a PDP-11, and consists of 32 16-bit words. When you access an address on the ROM, the circuit returns the represented data from that address.

GeomarCD project; an educational CD-Rom about marine geophysics

Science.gov (United States)

Diaz, J.; Rubio, E.; Gómez, M.; Gallart, J.

2009-04-01

This project aims to introduce the main aspects of marine geophysics experiments to the high school students. We have chosen to present the information in the form an interactive game in which, taking care of the scientific objectives and the technological and logistic resources, the player must found the best strategy to make one of the 3 research projects proposed. Along the game, the player is introduced to the main aspects of the plate tectonics theory and the crustal structure as well as to the main methodologies available (seismics, potencial fields, cores). Rather than being based in theoretical aspects, largely covered by other outreach projects, this work focuses in how a realistic problem can be solved through a field experiment. The game takes place in the researcher's desk and in an oceanographic vessel as the BIO Hesperides and includes the choice of the research project, the design and development of the field work and the interpretation of the results. At the end, the player must complete a questionnaire to elaborate the final report. The correct choice of the appropriate methodologies and its interpretation is necessary to succeed. CD copies in Spanish are freely available upon request.

Advances in Neutron Activation Analysis of Large Objects with Emphasis on Archaeological Examples. Results of a Coordinated Research Project. Annex II. Companion CD-ROM

International Nuclear Information System (INIS)

2018-03-01

This publication is a compilation of the main results and findings of an IAEA coordinated research project (CRP). In particular, it discusses an innovative variation of neutron activation analysis (NAA) known as large sample NAA (LSNAA). There is no other way to measure the bulk mass fractions of the elements present in a large sample (up to kilograms in mass) non-destructively. Examples amenable to LSNAA include irregularly shaped archaeological artefacts, excavated rock samples, large samples of assorted ore, and finished products, such as nuclear reactor components. Advantages of LSNAA applications, limitations and scientific and technological requirements are described in this publication, which serves as a reference of interest not only to the NAA experts, research reactor personnel, and those considering this technique, but also to various stakeholders and users such as researchers, industrialists, environmental and legal experts, and administrators. The county reports given in this companion CD-ROM (Annex II) give a global overview of all the accomplishments achieved by the participants during the CRP. However, in several cases common procedures were employed by several participating laboratories, constituting one general approach.

Learn with the Classics: Using Music To Study Smart at Any Age.

Science.gov (United States)

Andersen, Ole; Marsh, Marcy; Harvey, Arthur

This book, accompanied by a musical CD-ROM, provides information on how to enhance learning through music at any age. Sections include: (1) "Let Music Prime Your Brain For Learning," which teaches how important it is to prime the brain for learning through music; (2) "Study Smart," which demonstrates highly effective studying techniques devised by…

School Library Supplement. Putting Your Library Automation System to Work [and] Using Videodiscs in Research Projects [and] Library Security: What to Look For [and] Expanding Library/Media Services with Media Retrieval [and] How to Network CD-ROMs (and) The School Library Resource Directory.

Science.gov (United States)

Karpisek, Marian; And Others

1995-01-01

Presents five articles and a company resource directory to help librarians successfully incorporate technology into school libraries. Discusses actual situations, examines student needs, and gives advice to help librarians with library automation systems, videodiscs, library security systems, media retrieval, networking CD-ROMs, and locating…

Nonlinear Aerodynamic ROM-Structural ROM Methodology for Inflatable Aeroelasticity in Hypersonic Atmospheric Entry, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — ZONA Technology proposes to develop an innovative nonlinear structural reduced order model (ROM) - nonlinear aerodynamic ROM methodology for the inflatable...

Kodak's New Photo CD Portfolio: Multimedia for the Rest of Us.

Science.gov (United States)

Bonime, Andrew

1994-01-01

Describes Photo CD Portfolio, an Eastman Kodak product that provides interactive multimedia CD-ROM production capability. The article focuses on the capabilities of the tool's simplest authoring system, Create It, which allows users to work with Photo CD, PICT, or TIFF images, add graphics, text and audio, and create menus with branching. (KRN)

ChemSkill Builder 2000, Version 6.1 [CD-ROM] (by James D. Spain and Harold J. Peters)

Science.gov (United States)

Keeney-Kennicutt, Reviewed By Wendy L.

2000-07-01

One of the major challenges for faculty teaching general chemistry is how to encourage students to practice solving problems. We know that for students to develop chemical intuition and problem-solving skills, they must "get their hands dirty" as they decipher and unravel problems inherent to our discipline. One tool that I've used since its release in 1996 is the ChemSkill Builder, an electronic homework package. The latest version, ChemSkill Builder (CSB) 2000, version 6.1, is an excellent, effective integration of teaching and testing most quantitative and conceptual learning objectives in an interactive way. It is inexpensive and easy to use for both students and faculty. The CSB 2000 package of personalized problem sets, specifically designed to complement most general chemistry courses, is a program on CD-ROM for PC Windows users (3.1, 95, or 98), with more than 1500 questions and a 3 1/2-in. record-management disk. There is a separate grade-management disk for the instructor. It has 24 gradable chapters, each with 5 or 6 sections, plus two new chapters that are not graded: Polymer Chemistry and an Appendix of Chemical Skills. Each section begins with a short review of the topic and many have interactive explanations. If students miss an answer, they are given a second chance for 70% credit. If they still miss, the worked-out solution is presented in detail. Students can work each section as many times as they wish to improve their scores. Periodically, the students download their data directly into a PC set up by the instructor. The data can be easily converted into an ASCII file and merged with a spreadsheet. The use of CD-ROM solves the sporadic problems associated with previous versions on 3 1/2-in. disks: software glitches, failed disks, and system incompatibilities. The quality and number of graphics and interactive exercises are much improved in this latest version. I particularly enjoyed the interactive explanations of significant figures and

Numerical Recipes in C++: The Art of Scientific Computing (2nd edn). Numerical Recipes Example Book (C++) (2nd edn). Numerical Recipes Multi-Language Code CD ROM with LINUX or UNIX Single-Screen License Revised Version

International Nuclear Information System (INIS)

Borcherds, P

2003-01-01

(C++), the authors point out some of the problems in the use of C++ in scientific computing. I have not found any mention of parallel computing in NR(C++). Fortran has quite a lot going for it. As someone who has used it in most of its versions from Fortran II, I have seen it develop and leave behind other languages promoted by various enthusiasts: who now uses Algol or Pascal? I think it unlikely that C++ will disappear: it was devised as a systems language, and can also be used for other purposes such as scientific computing. It is possible that Fortran will disappear, but Fortran has the strengths that it can develop, that there are extensive Fortran subroutine libraries, and that it has been developed for parallel computing. To argue with programmers as to which is the best language to use is sterile. If you wish to use C++, then buy NR(C++), but you should also look at volume 2 of NR(F). If you are a Fortran programmer, then make sure you have NR(F), volumes 1 and 2. But whichever language you use, make sure you have one version or the other, and the CD ROM. The Example Book provides listings of complete programs to run nearly all the routines in NR, frequently based on cases where an analytical solution is available. It is helpful when developing a new program incorporating an unfamiliar routine to see that routine actually working, and this is what the programs in the Example Book achieve. I started teaching computational physics before Numerical Recipes was published. If I were starting again, I would make heavy use of both The Art of Scientific Computing and of the Example Book. Every computational physics teaching laboratory should have both volumes: the programs in the Example Book are included on the CD ROM, but the extra commentary in the book itself is of considerable value. (book review: Press, William H; Teukolsky, Saul A; Vettering, William T; Flannery, Brian P - ISBN 0-521-75034-4; ISBN 0-521-75034-2; ISBN 0-521-75036-9)

ROM a primera vista = ROM at first sight

Directory of Open Access Journals (Sweden)

Hugo Ricardo, D

2006-09-01

Full Text Available RESUMEN Objetivo:Es por todos conocida la importancia en la medición delROM (Range of motion: Rango de movimiento de una articulación, como elemento diagnóstico y evolutivo, pero, falta de uniformidad existe respecto a como debería ser registrado el ROM, de manera tal que otros profesionales pudieran interpretar los mismos resultados. Es objetivo de este trabajo, presentar una nueva técnica, rápida y eficaz para medir el ROM activo de las articulaciones de muñeca y dedos, sin necesidad de recurrir a un goniómetro o sistema similar.Material y métodos: La técnica se basa en darle a cada rango articular, desde la posición extrema, un valor máximo de 1 y un mínimo de 0 . Por ejemplo, si la extensión de muñeca es total, entonces corresponde valor 1; si la extensión de muñeca, no existe, entonces corresponde un valor de 0. Si la extensión llega a un 25% , se considera valor¼. Si la extensión llega a un 50%, se considera valor ½ .Si la extensión llega a un 75%, se considera valor ¾. Además, si al valor del ROM obtenido, le adosamos luego de un guión el valor 0, indicaráausencia de dolor. Si adosamos el valor 1, indicará presencia de dolor.Discusión: Esta técnica tiene evidentemente ciertas ventajas respecto a los métodos convencionales: Es más rápida, más cómoda, más simple, más fácil de aprender y recordar, y otros profesionales pueden apropiadamente interpretar los mismos resultados ABSTRACTObjective: we all are aware of the importance of the measuring of ROM in an articulation, as an element for diagnosis and evolution. Notwithstanding, there is a lack of uniformity concerning its registration to facilitate theinterpretation of the same results by other professionals.So that, the aim of this work is presenting a new, quick and effective technique to measure the active ROM of wrist and fingers joints without resorting to a goniometer or similar device.Material and methods: this technique consists of giving each

Wind Resource Atlas of Oaxaca (CD-ROM)

Energy Technology Data Exchange (ETDEWEB)

Elliott, D.; Schwartz, M.; Scott, G.; Haymes, S.; Heimiller, D.; George, R.

2003-08-01

The CD version of the Oaxaca Wind Resource Atlas, produced by the National Renewable Energy Laboratory's (NREL's) wind resource group, is the result of an extensive mapping study for the Mexican State of Oaxaca. This atlas identifies the wind characteristics and distribution of the wind resource in Oaxaca. The detailed wind resource maps and other information contained in the atlas facilitate the identification of prospective areas for use of wind energy technologies, both for utility-scale power generation and off-grid wind energy applications.

NODC Standard Product: International ocean atlas Volume 10 - Climatic atlas of the Sea of Azov 2006 (1 disc set) (NODC Accession 0098572)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This Atlas and accompanying CD-ROM contains oceanographic data collected by the Academy of Sciences, Ministry of Fisheries, and the Hydrometeorological Service of...

[Benchmarking and other functions of ROM: back to basics].

Science.gov (United States)

Barendregt, M

2015-01-01

Since 2011 outcome data in the Dutch mental health care have been collected on a national scale. This has led to confusion about the position of benchmarking in the system known as routine outcome monitoring (rom). To provide insight into the various objectives and uses of aggregated outcome data. A qualitative review was performed and the findings were analysed. Benchmarking is a strategy for finding best practices and for improving efficacy and it belongs to the domain of quality management. Benchmarking involves comparing outcome data by means of instrumentation and is relatively tolerant with regard to the validity of the data. Although benchmarking is a function of rom, it must be differentiated form other functions from rom. Clinical management, public accountability, research, payment for performance and information for patients are all functions of rom which require different ways of data feedback and which make different demands on the validity of the underlying data. Benchmarking is often wrongly regarded as being simply a synonym for 'comparing institutions'. It is, however, a method which includes many more factors; it can be used to improve quality and has a more flexible approach to the validity of outcome data and is less concerned than other rom functions about funding and the amount of information given to patients. Benchmarking can make good use of currently available outcome data.

Near-Horizontal, Two-Phase Flow Patterns of Nitrogen and Hydrogen at Low Mass Heat and Flux (on CD-ROM)

Science.gov (United States)

VanDresar, N. T.; Siegwarth, J. D.

2001-01-01

One reason for NASA's interest in cryogenic two-phase flow with low mass and heat flux is the need to design spacecraft heat exchangers used for vaporizing cryogenic propellants. The CD-ROM provides digitized movies of particular flow patterns observed in experimental work. The movies have been provided in (QuickTime9Trademark) format, encoded at 320w x 240h pixels, 15 fps, using the Sorenson(Trademark) Video Codec for compression. Experiments were conducted to obtain data on the two-phase (liquid and vapor) flow behavior of cryogenic nitrogen and hydrogen under low mass and heat flux conditions. Tests were performed in normal gravity with a 1.5 degree up flow configuration. View ports in the apparatus permitted visual observation of the two-phase flow patterns. Computer codes to predict flow patterns were developed from theoretical/empirical models reported in the literature. Predictions from the computer codes were compared with experimental flow pattern observations. Results are presented employing the traditional two-dimensional flow pattern map format using the liquid and gas superficial velocities as coordinates. In general, the agreement between the experimental results and the analytical predictive methods is reasonably good. Small regions of the flow pattern maps are identified where the models are deficient as a result of neglecting phase change phenomena. Certain regions of the maps were beyond the range of the experiments and could not be completely validated. Areas that could benefit from further work include modeling of the transition from separated flow, collection of additional data in the bubble and annular flow regimes, and collection of experimental data at other inclination angles, tube diameters and high heat flux.

Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patients

Directory of Open Access Journals (Sweden)

Xu Zhuwei

2009-06-01

Full Text Available Abstract Background As a cellular membrane triggering receptor, CD226 is involved in the NK cell- or CTL-mediated lysis of tumor cells of different origin, including freshly isolated tumor cells and tumor cell lines. Here, we evaluated soluble CD226 (sCD226 levels in sera, and membrane CD226 (mCD226 expression on peripheral blood mononuclear cells (PBMC from cancer patients as well as normal subjects, and demonstrated the possible function and origin of the altered sCD226, which may provide useful information for understanding the mechanisms of tumor escape and for immunodiagnosis and immunotherapy. Results Soluble CD226 levels in serum samples from cancer patients were significantly higher than those in healthy individuals (P P Conclusion These findings suggest that sCD226 might be shed from cell membranes by certain proteases, and, further, sCD226 may be used as a predictor for monitoring cancer, and more important, a possible immunotherapy target, which may be useful in clinical application.

In-line CD metrology with combined use of scatterometry and CD-SEM

Science.gov (United States)

Asano, Masafumi; Ikeda, Takahiro; Koike, Toru; Abe, Hideaki

2006-03-01

Measurement characteristics in scatterometry and CD-SEM for lot acceptance sampling of inline critical dimension (CD) metrology were investigated by using a statistical approach with Monte Carlo simulation. By operation characteristics curve analysis, producer's risk and consumer's risk arising from sampling were clarified. Single use of scatterometry involves a higher risk, such risk being particularly acute in the case of large intra-chip CD variation because it is unable to sufficiently monitor intra-chip CD variation including local CD error. Substituting scatterometry for conventional SEM metrology is accompanied with risks, resulting in the increase of unnecessary cost. The combined use of scatterometry and SEM metrology in which the sampling plan for SEM is controlled by scatterometry is a promising metrology from the viewpoint of the suppression of risks and cost. This is due to the effect that CD errors existing in the distribution tails are efficiently caught.

A CD-ROM About Radiation Protection Aspects of a Nuclear Accident: Towards more Openness and Transparency

International Nuclear Information System (INIS)

Oudiz, Andre

2003-01-01

Many players are involved in managing a nuclear accident apart from radiation protection and nuclear safety experts. In an emergency response situation, the decision making process involves many non-technical players who nonetheless have a major role to play: in France these may include the 'Prefet', the emergency and civil defence services, the health services, the police, the 'gendarmerie' and local councillors, with advice from the safety and radiological protection authorities and expert evaluation organisations. Within the post-accident response, other players will be involved alongside those already described : professional bodies, particularly farming organisations, residents' associations, those responsible for environmental decontamination, agencies responsible for compensating victims, etc., etc. In both the short and the long-term phases of the crisis management process, it is essential to enable participants who may have very different -backgrounds and professional experience to work together with co-operation and mutual understanding. If non-technical players are to contribute effectively, there needs to be a minimum level of mutual understanding between them and the technical. players on what the nuclear risk really is and what is the rationale of the short and long term counter-measures aimed at protecting the public and restoring the contaminated environment. Local communities also need to share this basic understanding because their cooperation is required in order to implement the countermeasures properly. Conversely, if the experts are to advise the local authorities properly, they need to understand the criteria on which these local authorities and communities base their decisions: what psycho sociological factors apply, what logistical support is needed, what are the concerns of the local communities? The CD-ROM should help in gradually building up a shared interpretation or culture of the nuclear risk. This forum should promote debate that is

Mawul Rom Project: Openness, obligation and reconciliation

NARCIS (Netherlands)

Brigg, M.; Tonnaer, A.A.C.

2008-01-01

Aboriginal Australian initiatives to restore balanced relationships with White Australians have recently become part of reconciliation efforts. This paper provides a contextualised report on one such initiative, the Mawul Rom cross-cultural mediation project. Viewing Mawul Rom as a diplomatic

Review of Excavating Occaneechi Town: Archaeology of an Eighteenth-Century Indian Village in North Carolina. 1998, edited by R.P. Stephen Davis Jr., Patrick C. Livingood, Trawick Ward, and Vincas P. Steponaitis. University of North Carolina Press. ISBN 0-8078-6503-6 [CD-ROM

Directory of Open Access Journals (Sweden)

Jonathan Bateman

1999-05-01

Full Text Available The CD-ROM Excavating Occaneechi Town: Archaeology of an Eighteenth-Century Indian Village in North Carolina has become a familiar site on my desk in the last few months. Not, I admit, because I have been avidly scouring its content on a regular basis, but because I have been putting off writing this review. A wealth of information can be an intimidating thing.

Development of an Integrated Approach to Routine Automation of Neutron Activation Analysis. Results of a Coordinated Research Project. Companion CD-ROM. Annex II: Country Reports

International Nuclear Information System (INIS)

2018-04-01

Neutron activation analysis (NAA) is a powerful technique for determining bulk composition of major and trace elements. Automation may contribute significantly to keep NAA competitive for end-users. It provides opportunities for a larger analytical capacity and a shorter overall turnaround time if large series of samples have to be analysed. This publication documents and disseminates the expertise generated on automation in NAA during a coordinated research project (CRP). The CRP participants presented different cost-effective designs of sample changers for gamma-ray spectrometry as well as irradiation devices, and were able to construct and successfully test these systems. They also implemented, expanded and improved quality control and quality assurance as cross-cutting topical area of their automated NAA procedures. The publication serves as a reference of interest to NAA practitioners, experts, and research reactor personnel, but also to various stakeholders and users interested in basic research and/or services provided by NAA. This CD-ROM contains the individual country reports

Comment scolariser les enfants Roms? Les enfants Roms dans les dispositifs mis en place à Bordeaux Métropole.

OpenAIRE

Øhlund, Ida

2016-01-01

Dans ce mémoire, je m intéresse à la scolarisation des enfants Roms en France. Je présente la place des enfants Roms dans la scolarisation en Europe et en France. Je discute les efforts qu on fait en France pour scolariser ces enfants, et je prends comme exemple les mesures d intégration prises par les autorités de Bordeaux Métropole en expliquant les rôles des différents acteurs locaux. Dans la première partie, j essaye de présenter le groupe minoritaire européen appelé « Rom ». J aborde l h...

The Cerefy registered clinical brain atlas on CD-ROM. Based on the classic Talairach-Tournoux and Schaltenbrand-Wahren brain atlases. 2. ed.

International Nuclear Information System (INIS)

Nowinski, W.L.; Thirunavuukarasuu, A.

2001-01-01

This remarkable CD-ROM provides enhanced and extended versions of three world-famous Thieme atlases, (Schaltenbrand and Wahren's Atlas for Stereotaxy of the Human Brain, Talairach and Tournoux's Co-Planar Stereotaxis Atlas of the Human Brain and Referentially Oriented Cerebral MRI Anatomy). It contains the electronic atlases as well as an easy navigation system to facilitate searching for and displaying more than 525 anatomical structures. Revolutionizing the field of brain anatomy, the authors have segmented, labeled, and cross referenced all the information contained in the books, and created contours for all three atlases. The Cerefy registered Clinical Brain Atlas now allows you to electronically navigate these atlases simultaneously on axial, coronal, and sagittal planes, and enjoy the ability to: 1. Access 210 high-quality, fully segmented, and labeled atlas images with corresponding contours, 2. Display and manipulate spatially co-registered atlases, 3. Dynamically label images with structure names and descriptions, and then highlight selected structures in the atlas image, 4. Image zoom in five different levels, mensurate, search, set triplanar, get coordinates, save, and print, 5. Access on-line help, glossary, and supportive atlas materials. (orig.)

Noziegums un sods Grama Svifta romānā "Dienas gaisma" un Fjodora Dostojevska romānā "Noziegums un sods"

OpenAIRE

Hohlova, Marija

2008-01-01

Šis bakalaura darbs pēta nozieguma un soda tēmu Fjodora Dostojevska romānā "Noziegums un sods" un Grema Svifta romānā "Dienas gaisma". Darbs sastāv no četrām nodaļām. Pirmajā nodaļā, kura pamatīgi aplūko nozieguma folozofiju, autore piemin integrēto pieeju nozieguma parādībai folozofijas skatījumā, kā arī analīzē nozieguma metafiziskās un socioloģiskās īpatnības uz Fjodora Dostojevska romāna "Noziegums un sods" pamata. Otrā nodaļa apraksta Fjodora Dostojevska romāna "Noziegums un sods" un Gre...

The power of change conference

International Nuclear Information System (INIS)

Anon.

1995-01-01

Business aspects of the electrical power utility industry in Canada were discussed in these proceedings of The Power of Change Conference, held in Vancouver, BC on April 9-11, 1995. Topics of discussion included the future of the electric utility industry in Canada, integrated resource planning, rate design, load forecasting, regulatory changes, supplier relationships, training needs and economic and demographic outlooks. These proceedings were accompanied by proceedings from four other conferences in a digital CD-ROM format

Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses.

Science.gov (United States)

Friedman, Gregory K; Moore, Blake P; Nan, Li; Kelly, Virginia M; Etminan, Tina; Langford, Catherine P; Xu, Hui; Han, Xiaosi; Markert, James M; Beierle, Elizabeth A; Gillespie, G Yancey

2016-02-01

Childhood medulloblastoma is associated with significant morbidity and mortality that is compounded by neurotoxicity for the developing brain caused by current therapies, including surgery, craniospinal radiation, and chemotherapy. Innate therapeutic resistance of some aggressive pediatric medulloblastoma has been attributed to a subpopulation of cells, termed cancer-initiating cells or cancer stemlike cells (CSCs), marked by the surface protein CD133 or CD15. Brain tumors characteristically contain areas of pathophysiologic hypoxia, which has been shown to drive the CSC phenotype leading to heightened invasiveness, angiogenesis, and metastasis. Novel therapies that target medulloblastoma CSCs are needed to improve outcomes and decrease toxicity. We hypothesized that oncolytic engineered herpes simplex virus (oHSV) therapy could effectively infect and kill pediatric medulloblastoma cells, including CSCs marked by CD133 or CD15. Using 4 human pediatric medulloblastoma xenografts, including 3 molecular subgroup 3 tumors, which portend worse patient outcomes, we determined the expression of CD133, CD15, and the primary HSV-1 entry molecule nectin-1 (CD111) by fluorescence activated cell sorting (FACS) analysis. Infectability and cytotoxicity of clinically relevant oHSVs (G207 and M002) were determined in vitro and in vivo by FACS, immunofluorescent staining, cytotoxicity assays, and murine survival studies. We demonstrate that hypoxia increased the CD133+ cell fraction, while having the opposite effect on CD15 expression. We established that all 4 xenografts, including the CSCs, expressed CD111 and were highly sensitive to killing by G207 or M002. Pediatric medulloblastoma, including Group 3 tumors, may be an excellent target for oHSV virotherapy, and a clinical trial in medulloblastoma is warranted. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Reactive oxygen metabolites (ROMs) are associated with cardiovascular disease in chronic hemodialysis patients.

Science.gov (United States)

Bossola, Maurizio; Vulpio, Carlo; Colacicco, Luigi; Scribano, Donata; Zuppi, Cecilia; Tazza, Luigi

2012-02-11

The aim of our study was to measure reactive oxygen metabolites (ROMs) in chronic hemodialysis (HD) patients and evaluate the possible association with cardiovascular disease (CVD) and mortality. We measured ROMs in 76 HD patients and correlated with CVD, cardiovascular (CV) events in the follow-up and all-cause and CVD-related mortality. The levels of ROMs presented a median value of 270 (238.2-303.2) CARR U (interquartile range). We created a ROC curve (ROMs levels vs. CVD) and we identified a cut-off point of 273 CARR U. Patients with ROMs levels ≥273 CARR U were significantly older, had higher C-reactive protein levels and lower creatinine concentrations. The prevalence of CVD was higher in patients with ROMs levels ≥273 (87.1%) than in those with ROMs levels <273 CARR U (17.7%; p<0.0001). ROMs levels were significantly higher in patients with CVD (317±63.8) than in those without (242.7±49.1; p<0.0001). At multiple regression analysis, age, creatinine and C-reactive protein were independent factors associated with ROMs. At multiple logistic regression analysis the association between ROMs and CVD was independent (OR: 1.02, 95% CI: 1.00-1.05; p=0.03). Twenty six patients developed cardiovascular (CV) events during the follow-up. Of these, seven were in the group with ROMs levels <273 CARR U and 19 in the group with ROMs levels ≥273 CARR U. The logistic regression analysis showed that both age (OR: 1.06, 95% CI: 1.01-1.12; p=0.013) and ROMs levels (OR: 1.10, 95% CI: 1.00-1.02; p=0.045) were independently associated with CV events in the follow-up. ROMs are independently associated with CVD and predict CV events in chronic HD patients.

Syd for Rom

DEFF Research Database (Denmark)

Frandsen, Steen Bo

Bogen fortæller historien om et af Europas mest berømte vildnisser, De Pontinske Sumpe, der strakte sig i kystlandet umiddelbart syd for Rom fra romertiden til tørlægningen og forvandlingen til landbrugsland i 1930'erne. Allerede under romerne vandt sumpen uophørligt terræn og forvandlede det fla...

FPGA Based Low Power ROM Design Using Capacitance Scaling

DEFF Research Database (Denmark)

Bansal, Meenakshi; Bansal, Neha; Saini, Rishita

2015-01-01

An ideal capacitor will not dissipate any power, but a real capacitor wil l have some power dissipation. In this work, we are going to design capacitance scaling based low power ROM design. In order to test the compatibility of this ROM design with latest i7 Processor, we are operating this ROM w...... in I/O Power, saving of 0.2% occur in Leakage Power, there will be a saving of 11.54% occur in Total Power. This design is implemented on Virtex-5 FPGA using Xilinx ISE and Verilog....

38th MPA-Seminar 2012. Power generation and energy efficiency. Materials and component behaviour

International Nuclear Information System (INIS)

2012-01-01

This conference paper contains the abstracts of lectures and posters. On the accompanying CD-ROM are the manuscripts of the lectures and posters. The four main topics of this paper are: Nuclear Energy; Alternative energy generation; Sealing technology; and Power Plants. 17 of the papers are separately analyzed for this database.

Modeling and simulation for RF system design

CERN Document Server

Frevert, Ronny; Jancke, Roland; Knöchel, Uwe; Schwarz, Peter; Kakerow, Ralf; Darianian, Mohsen

2005-01-01

Focusing on RF specific modeling and simulation methods, and system and circuit level descriptions, this work contains application-oriented training material. Accompanied by a CD- ROM, it combines the presentation of a mixed-signal design flow, an introduction into VHDL-AMS and Verilog-A, and the application of commercially available simulators.

Functional Behavioral Assessment: An Interactive Training Module. User's Manual & Facilitator's Guide. Second Edition.

Science.gov (United States)

Liaupsin, Carl J.; Scott, Terry M.; Nelson, C. Michael

This user's manual and facilitator's guide is intended for use with an accompanying interactive CD-ROM to provide a complete training program in conducting functional behavioral assessments (FBAs) as required under the 1997 reauthorization of the Individuals with Disabilities Education Act. Chapter 1 provides general information for users, such as…

Calculation method of passive tracer using regional ocean modeling system (ROMS)

International Nuclear Information System (INIS)

Tubono, Takaki; Tsumune, Daisuke; Misumi, Kazuhiro; Yoshida, Yoshikatsu

2010-01-01

A dose assessments method for packages shipping radioactive materials was developed to calculate concentrations of radioactive materials discharged from the hypothetically sinking point using Regional Ocean Modeling System (ROMS). The programs of ROMS were improved for simultaneously calculating the flow fields around Japan and the concentrations discharged from several bottom points in the continental shelf. The model domain covered the northeast pacific region around Japan, 20degN-65degN, 120degE-165degE, with 1/10 degree horizontal resolution and 30 sigma-levels. The ROMS model captured main features such as Kuroshio currents, including the separation location and the Kuroshio extension, and Oyashio currents. The calculated volume transports through the main straits such as Tokara strait, Tsushima strait and Tsugaru strait were compared well to the measured or estimated that. The calculated concentrations discharged from 12 bottom points showed mixing associated with the eddies of ocean currents. This method is available to evaluate effectively the concentrations of radioactive materials only by setting the subsidence location and the concentrations and volume discharged. (author)

Our God is Gold: Vlashika Rom at a Crossroads?

Directory of Open Access Journals (Sweden)

Andrš Zbyněk

2016-12-01

Full Text Available This article explicates the sociocultural dynamics in the changing lives of the Vlashika Rom group in the Czech and Slovak Republics and contemplates the prospective development of this Roma subculture. To provide a better insight into the endeavour of the Vlashika Rom to maintain their integrity and into their adaptation strategies, the author outlines the genesis of this subethnic group, pointing out the historical circumstances that have formed them in the past. Contrary to former descriptions, the author provides an entirely new concept for dividing the Vlashika Rom into subgroups, identifying three distinct levels that create social boundaries within this community. He describes the way of living of this subgroup in the past as well as the relationships between the Vlashika Rom and the dominant society. Frequently antagonistic, these relationships depend on their way of life, substantially determined by the way they earn their living. The author analyses the inner resources that keep sustaining the contemporary Vlashika Rom culture and, drawing on his own experience and impulses from literature, inquires how long this anachronistic yet at the same time very adaptable culture will be able to resist the assimilation pressures deriving from the very nature of the modern national state.

A, B, CD, DVD: Marketing Higher Education to the Millennial Generation

Science.gov (United States)

Furbeck, Lee F.; Harding, Marc L.; Wohlgemuth, Darin R.; Bousquet, David R.

2003-01-01

Based on compelling financial and strategic reasons, Iowa State University replaced its paper viewbook with a CD-ROM digital viewbook following the Fall 1998 recruiting cycle. The first interactive DVD viewbook debuted for the Fall 2003 recruiting cycle, following a qualitative research study designed to gauge the effectiveness of the medium.…

Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

Directory of Open Access Journals (Sweden)

Hiscox Stephen

2012-10-01

Full Text Available Abstract Background Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases. Breast cancer cell models reveal that endocrine resistance is accompanied by a gain in aggressive behaviour driven in part through altered growth factor receptor signalling, particularly involving erbB family receptors. Recently we identified that CD44, a transmembrane cell adhesion receptor known to interact with growth factor receptors, is upregulated in tamoxifen-resistant (TamR MCF7 breast cancer cells. The purpose of this study was to explore the consequences of CD44 upregulation in an MCF7 cell model of acquired tamoxifen resistance, specifically with respect to the hypothesis that CD44 may influence erbB activity to promote an adverse phenotype. Methods CD44 expression in MCF7 and TamR cells was assessed by RT-PCR, Western blotting and immunocytochemistry. Immunofluorescence and immunoprecipitation studies revealed CD44-erbB associations. TamR cells (± siRNA-mediated CD44 suppression or MCF7 cells (± transfection with the CD44 gene were treated with the CD44 ligand, hyaluronon (HA, or heregulin and their in vitro growth (MTT, migration (Boyden chamber and wound healing and invasion (Matrigel transwell migration determined. erbB signalling was assessed using Western blotting. The effect of HA on erbB family dimerisation in TamR cells was determined by immunoprecipitation in the presence or absence of CD44 siRNA. Results TamR cells overexpressed CD44 where it was seen to associate with erbB2 at the cell surface. siRNA-mediated suppression of CD44 in TamR cells significantly attenuated their response to heregulin, inhibiting heregulin-induced cell migration and invasion. Furthermore, TamR cells exhibited enhanced sensitivity to HA, with HA treatment resulting in modulation of erbB dimerisation, ligand-independent activation of erbB2

Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

International Nuclear Information System (INIS)

Hiscox, Stephen; Gee, Julia; Baruha, Bedanta; Smith, Chris; Bellerby, Rebecca; Goddard, Lindy; Jordan, Nicola; Poghosyan, Zaruhi; Nicholson, Robert I; Barrett-Lee, Peter

2012-01-01

Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases. Breast cancer cell models reveal that endocrine resistance is accompanied by a gain in aggressive behaviour driven in part through altered growth factor receptor signalling, particularly involving erbB family receptors. Recently we identified that CD44, a transmembrane cell adhesion receptor known to interact with growth factor receptors, is upregulated in tamoxifen-resistant (TamR) MCF7 breast cancer cells. The purpose of this study was to explore the consequences of CD44 upregulation in an MCF7 cell model of acquired tamoxifen resistance, specifically with respect to the hypothesis that CD44 may influence erbB activity to promote an adverse phenotype. CD44 expression in MCF7 and TamR cells was assessed by RT-PCR, Western blotting and immunocytochemistry. Immunofluorescence and immunoprecipitation studies revealed CD44-erbB associations. TamR cells (± siRNA-mediated CD44 suppression) or MCF7 cells (± transfection with the CD44 gene) were treated with the CD44 ligand, hyaluronon (HA), or heregulin and their in vitro growth (MTT), migration (Boyden chamber and wound healing) and invasion (Matrigel transwell migration) determined. erbB signalling was assessed using Western blotting. The effect of HA on erbB family dimerisation in TamR cells was determined by immunoprecipitation in the presence or absence of CD44 siRNA. TamR cells overexpressed CD44 where it was seen to associate with erbB2 at the cell surface. siRNA-mediated suppression of CD44 in TamR cells significantly attenuated their response to heregulin, inhibiting heregulin-induced cell migration and invasion. Furthermore, TamR cells exhibited enhanced sensitivity to HA, with HA treatment resulting in modulation of erbB dimerisation, ligand-independent activation of erbB2 and EGFR and induction of cell migration

The Distribution of Information: The Role for Online Public Access Catalogs.

Science.gov (United States)

Matthews, Joseph R.

1994-01-01

Describes the Online Public Access Catalog (OPAC) and the inclusion of abstracting and indexing industry databases in OPACs. Topics addressed include the implications of including abstracting and indexing tape and CD-ROM products in OPACs; the need for standards allowing library systems to communicate with dissimilar CD-ROM products; and computer,…

IAEA fast reactor knowledge preservation initiative. Project focus: KNK-II reactor, Karlsruhe, Germany

International Nuclear Information System (INIS)

2004-08-01

This Working Material (including the attached CD-ROM) documents progress made in the IAEA's initiative to preserve knowledge in the fast reactor domain. The brochure describes briefly the context of the initiative and gives an introduction to the contents of the CD-ROM. In 2003/2004 a first focus of activity was concentrated on the preservation of knowledge related to the KNK-II experimental fast reactor in Karlsruhe, Germany. The urgency of this project was given by the impending physical destruction of the installation, including the office buildings. Important KNK-II documentation was brought to safety and preserved just in time. The CD-ROM contains the full texts of 264 technical and scientific documents describing research, development and operating experience gained with the KNK-II installation over a period of time from 1965 to 2002, extending through initial investigations, 17 years of rich operating experience, and final shutdown and decommissioning. The index to the documents on the CD-ROM is printed at the end of this booklet in chronological order and is accessible on the CD by subject index and chronological index. The CD-ROM contains in its root directory also the document 'fr c lassification.pdf' which describes the classification system used for the present collection of documents on the fast reactor KNK-II

Environmental Management System ISO 14001

CERN Document Server

Haider, Syed

2010-01-01

This is a must-have tool for any company in the process of adopting and incorporating the ISO 14001:2004 requirements, this book and accompanying CD-ROM provides the latest updates and amendments and translates the ISO language into actionable strategy. Offering administrative solutions to managers of all sorts, it includes practical examples of policies with objectives, targets, and action plans applicable to any process related industry or an ordinary organization. With template formats and hands-on flow charts to describe step-by-step system development, documentation, and implementation ph

Thoracic ROM measurement system with visual bio-feedback: system design and biofeedback evaluation.

Science.gov (United States)

Ando, Takeshi; Kawamura, Kazuya; Fujitani, Junko; Koike, Tomokazu; Fujimoto, Masashi; Fujie, Masakatsu G

2011-01-01

Patients with diseases such as chronic obstructive pulmonary disease (COPD) need to improve their thorax mobility. Thoracic ROM is one of the simplest and most useful indexes to evaluate the respiratory function. In this paper, we have proposed the prototype of a simple thoracic ROM measurement system with real-time visual bio-feedback in the chest expansion test. In this system, the thoracic ROM is measured using a wire-type linear encoder whose wire is wrapped around the thorax. In this paper, firstly, the repeatability and reliability of measured thoracic ROM was confirmed as a first report of the developed prototype. Secondly, we analyzed the effect of the bio-feedback system on the respiratory function. The result of the experiment showed that it was easier to maintain a large and stable thoracic ROM during deep breathing by using the real-time visual biofeedback system of the thoracic ROM.

Is there a role for rifampicin, ofloxacin and minocycline (ROM) therapy in the treatment of leprosy? Systematic review and meta-analysis.

Science.gov (United States)

Setia, Maninder S; Shinde, Santosh S; Jerajani, Hemangi R; Boivin, Jean-François

2011-12-01

A combination of rifampicin, ofloxacin and minocycline (ROM) is one of the newer recommendations for treatment of leprosy. We performed a systematic review and a meta-analysis of studies that had evaluated the efficacy of ROM therapy in treatment of paucibacillary and multibacillary leprosy patients. Studies were identified by searching the PubMed, Embase, LILACS and Cochrane databases. Data were abstracted from all relevant studies, and fixed effects models were used to calculate the summary estimate of effect in paucibacillary and multibacillary leprosy patients. Six studies comparing ROM therapy to multidrug therapy and eight studies that evaluated the effect of ROM therapy alone (no comparison group) were included in the review and meta-analysis. The combined estimate for single dose ROM vs. multidrug therapy in paucibacillary leprosy patients suggested that ROM was less effective than multidrug therapy in these patients [relative risk: 0.91, 95% confidence intervals (CI): 0.86-0.97]. However, the combined estimate for multiple doses of ROM vs. multidrug therapy in multibacillary leprosy patients suggested that ROM was as effective as multidrug therapy in reducing bacillary indices in these patients (proportion change: -4%, 95% CI -31% to 23%). No major side effects were reported in either the ROM or the multidrug treatment groups. Single-dose ROM therapy was less effective than multidrug therapy in paucibacillary patients. However, there are insufficient data to come to a valid conclusion on the efficacy of multidose ROM therapy in multibacillary leprosy, and additional studies with ROM therapy in multibacillary leprosy are needed. Furthermore, multiple doses may be considered as another alternative even for paucibacillary patients, and randomised controlled trials of this therapy may be useful to understand its contribution in the treatment and control of leprosy. © 2011 Blackwell Publishing Ltd.

Review

NARCIS (Netherlands)

Nooteboom, Hans P.

2000-01-01

This is a CD-ROM intended to identify 1733 species of trees and shrubs of northern Australian rain forests, accompanied by a user guide in book form. In the guide, in the chapter ‘Using the program’, a picture of the opening screen is given. At the bot-tom is the status bar, which, however, only

Regional Ocean Modeling System (ROMS): CNMI

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 7-day, 3-hourly forecast for the region surrounding the Commonwealth of the Northern Mariana Islands (CNMI) at approximately...

Regional Ocean Modeling System (ROMS): Samoa

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 7-day, 3-hourly forecast for the region surrounding the islands of Samoa at approximately 3-km resolution. While considerable...

Regional Ocean Modeling System (ROMS): Guam

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 6-day, 3-hourly forecast for the region surrounding Guam at approximately 2-km resolution. While considerable effort has been...

Regional Ocean Modeling System (ROMS): Oahu

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 7-day, 3-hourly forecast for the region surrounding the island of Oahu at approximately 1-km resolution. While considerable...

Status and trends of nuclear technologies - Report of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). Additional information (Companion CD-ROM)

International Nuclear Information System (INIS)

2009-09-01

The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was launched in the year 2000, based on a resolution by the IAEA General Conference (GC(44)/RES/21). INPRO intends to help to ensure that nuclear energy is available in the 21st century in a sustainable manner, and seeks to bring together all interested Member States, both technology holders and technology users, to consider, jointly, actions to achieve desired innovations. INPRO is taking care of the specific needs of developing countries. This IAEA publication is part of Phase 1 of INPRO. It intends to provide an overview on history, present situation and future perspectives of nuclear fuel cycle technologies. While this overview focuses on technical issues, nevertheless, the aspects of economics, environment, and safety and proliferation resistance are important background issues for this study. After a brief description about the INPRO project and an evaluation of existing and future reactor designs the publication covers nuclear fuel cycle issues in detail. It is expected that this documentation will provide IAEA Member States and their nuclear engineers and designers, as well as policy makers with useful information on status and trends of future nuclear fuel cycle technologies. Due to the size of the full report it was decided to attach a CD-ROM in the back of the summary report

SM-ROM-GL (Strong Motion Romania Ground Level Database

Directory of Open Access Journals (Sweden)

Ioan Sorin BORCIA

2015-07-01

Full Text Available The SM-ROM-GL database includes data obtained by the processing of records performed at ground level by the Romanian seismic networks, namely INCERC, NIEP, NCSRR and ISPH-GEOTEC, during recent seismic events with moment magnitude Mw ≥ 5 and epicenters located in Romania. All the available seismic records were re-processed using the same basic software and the same procedures and options (filtering and baseline correction, in order to obtain a consistent dataset. The database stores computed parameters of seismic motions, i.e. peak values: PGA, PGV, PGD, effective peak values: EPA, EPV, EPD, control periods, spectral values of absolute acceleration, relative velocity and relative displacement, as well as of instrumental intensity (as defined bz Sandi and Borcia in 2011. The fields in the database include: coding of seismic events, stations and records, a number of associated fields (seismic event source parameters, geographical coordinates of seismic stations, links to the corresponding ground motion records, charts of the response spectra of absolute acceleration, relative velocity, relative displacement and instrumental intensity, as well as some other representative parameters of seismic motions. The conception of the SM-ROM-GL database allows for an easy maintenance; such that elementary knowledge of Microsoft Access 2000 is sufficient for its operation.

Use of the Benchmarking System for Operational Waste from WWER Reactors

International Nuclear Information System (INIS)

2017-06-01

The focus of this publication is on benchmarking low and intermediate level waste generated and managed during the normal operating life of a WWER, and it identifies and defines the benchmarking parameters selected for WWER type reactors. It includes a brief discussion on why those parameters were selected and their intended benchmarking benefits, and provides a description of the database and graphical user interface selected, designed and developed, including how to use it for data input and data analysis. The CD-ROM accompanying this publication provides an overview of practices at WWER sites, which were to a large extent prepared using the WWER BMS.

BOREAS Level-3a Landsat TM Imagery: Scaled At-sensor Radiance in BSQ Format

Science.gov (United States)

Nickerson, Jaime; Hall, Forrest G. (Editor); Knapp, David; Newcomer, Jeffrey A.; Cihlar, Josef

2000-01-01

For BOREAS, the level-3a Landsat TM data, along with the other remotely sensed images, were collected in order to provide spatially extensive information over the primary study areas. This information includes radiant energy, detailed land cover, and biophysical parameter maps such as FPAR and LAI. Although very similar in content to the level-3s Landsat TM products, the level-3a images were created to provide users with a more usable BSQ format and to provide information that permitted direct determination of per-pixel latitude and longitude coordinates. Geographically, the level-3a images cover the BOREAS NSA and SSA. Temporally, the images cover the period of 22-Jun-1984 to 30-Jul-1996. The images are available in binary, image-format files. With permission from CCRS and RSI, several of the full-resolution images are included on the BOREAS CD-ROM series. Due to copyright issues, the images not included on the CD-ROM may not be publicly available. See Sections 15 and 16 for information about how to acquire the data. Information about the images not on the CD-ROMs is provided in an inventory listing on the CD-ROMs.

Neuroendocrine-immune and metabolic accompaniments of cholecystokinetic effects of balneotherapy on SPA Truskavets’

Directory of Open Access Journals (Sweden)

O M Marfiyan

2015-05-01

4Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland w.zukow@ukw.edu.pl   SUMMARY   Objective. Ability balneofactors spa Truskavets’ (Ukraine, including bioactive water Naftussya, affect Gall-bladder motility has long been known. We set a goal to identify changes related neuroendocrine-immune complex and metabolism accompanying cholecystokinetic effect of balneotherapy on spa. Results. In observation of 22 men with chronic cholecystitis in combination with pyelonephritis, found that 10-12-day course of balneotherapy (drinking of bioactive water Naftussya, application of ozokerite, mineral baths reduces Gall-bladder volume fasting by 16% (p0,05, by increasing PSD HF greater extent than LF. The basal levels of plasma cortisol decreased by 20% (p0,2 and 8% (p<0,05 respectively. Regarding immunity parameters revealed significant increase in blood CD16+ lymphocytes only (+17%, p<0,01 in the absence of changes in levels of CD3+CD4+ and CD3+CD8+ T cells and CD19+ B lymphocytes. Do not change significantly either serum Igg G, M, A, or circulating immune complexes. Finally, stated a slight but significant increase electrokinetic index cell nuclei of buccal epithelium, indicating the "rejuvenation" of the body. Conclusion: balneotherapy on spa Truskavets’ be significantly cholecystokinetic effect, combined with the activation excretory and depurative kidney functions and neutrophil bactericidal function against a background of lower levels of neuroendocrine markers of stress. Keywords: Truskavets’, balneotherapy, cholekinetic, diuresis, neuroendocrine-immune complex.

Chinese Language Video Clips. [CD-ROM].

Science.gov (United States)

Fleming, Stephen; Hipley, David; Ning, Cynthia

This compact disc includes video clips covering six topics for the learner of Chinese: personal information, commercial transactions, travel and leisure, health and sports, food and school. Filmed on location in Beijing, these naturalistic video clips consist mainly of unrehearsed interviews of ordinary people. The learner is lead through a series…

Validation of accuracy and reliability of a simple measurement device for the lumber range of motion (SMD-L-ROM)

International Nuclear Information System (INIS)

Kato, Nakayuki; Fujiwara, Atsushi; Honda, Toshio; Taneichi, Hiroshi

2007-01-01

It is important to evaluate mobility of the lumbar spine for assessment of lumbar spinal disorders and their therapeutic effects. We developed a simple measurement device for the lumbar range of motion (SMD-L-ROM) which can be installed on the trunk. SMD-L-ROM allows to evaluate mobility of the lumbar spine without x-ray exposure. Accuracy and reliability of the measurement device was assessed in this article. SMD-L-ROM comprises two metallic immobilization plates (IPs) with a vertically installed bar and a rubber band for fixation of IP to the trunk. Two IPs were installed at the level of Th12 and the sacrum. Range of motion (ROM) of the lumbar spine was measured by using SMD-L-ROM and radiographic modalities (X-ray and CT). Consistency of the measured values by both of SMD-L-ROM and radiographic modalities was evaluated. Furthermore, inter- and intra-observer agreement of measured values by SMD-L-ROM was assessed. Regarding measurement of ROM, there was a high correlation between SMD-L-ROM and X-ray/CT especially in the sagittal and axial plane. There was no significant difference in the average values of ROM between the two methods. On the other hand, SMD-L-ROM did not detect accurate position of the lumbar spine in all dimensions. There were no inter- and intra-observer errors of measured values by SMD-L-ROM. ROM of the lumbar spine was simply and economically measured with SMD-L-ROM. Accuracy and reliability of SMD-L-ROM was good enough for ROM measurement in the lumbar spine. (author)

A Fluid Mechanics Hypercourse

Science.gov (United States)

Fay, James A.; Sonwalkar, Nishikant

1996-05-01

This CD-ROM is designed to accompany James Fay's Introduction to Fluid Mechanics. An enhanced hypermedia version of the textbook, it offers a number of ways to explore the fluid mechanics domain. These include a complete hypertext version of the original book, physical-experiment video clips, excerpts from external references, audio annotations, colored graphics, review questions, and progressive hints for solving problems. Throughout, the authors provide expert guidance in navigating the typed links so that students do not get lost in the learning process. System requirements: Macintosh with 68030 or greater processor and with at least 16 Mb of RAM. Operating System 6.0.4 or later for 680x0 processor and System 7.1.2 or later for Power-PC. CD-ROM drive with 256- color capability. Preferred display 14 inches or above (SuperVGA with 1 megabyte of VRAM). Additional system font software: Computer Modern postscript fonts (CM/PS Screen Fonts, CMBSY10, and CMTT10) and Adobe Type Manager (ATM 3.0 or later). James A. Fay is Professor Emeritus and Senior Lecturer in the Department of Mechanical Engineering at MIT.

A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection

Directory of Open Access Journals (Sweden)

Feifei Qiu

2017-11-01

Full Text Available Due to vigorous alloimmunity, an allograft is usually rejected without any conventional immunosuppressive treatment. However, continuous global immunosuppression may cause severe side effects, including tumors and infections. Mounting evidence has shown that cyclosporine (CsA, a common immunosuppressant used in clinic, impedes allograft tolerance by dampening regulatory T cells (Tregs, although it inhibits allograft rejection at the same time. Therefore, it is necessary to seek an alternative immunosuppressive drug that spares Tregs with high efficiency in suppression but low toxicity. In this study, we investigated the capacity of emodin, an anthraquinone molecule originally extracted from certain natural plants, to prolong transplant survival in a mouse model and explored the cellular and molecular mechanisms underlying its action. We found that emodin significantly extended skin allograft survival and hindered CD3+ T cell infiltration in the allograft, accompanied by an increase in CD4+Foxp3+ and CD8+CD122+ Treg frequencies and numbers but a reduction in effector CD8+CD44highCD62Llow T cells in recipient mice. Emodin also inhibited effector CD8+ T cells proliferation in vivo. However, CD4+CD25+, but not CD8+CD122+, Tregs derived from emodin-treated recipients were more potent in suppression of allograft rejection than those isolated from control recipients, suggesting that emodin also enhances the suppressive function of CD4+CD25+ Tregs. Interestingly, depleting CD25+ Tregs largely reversed skin allograft survival prolonged by emodin while depleting CD122+ Tregs only partially abrogated the same allograft survival. Furthermore, we found that emodin hindered dendritic cell (DC maturation and reduced alloantibody production posttransplantation. Finally, we demonstrated that emodin inhibited in vitro proliferation of T cells and blocked their mTOR signaling as well. Therefore, emodin may be a novel mTOR inhibitor that suppresses alloimmunity by

Human natural killer cell maturation defect supports in vivo CD56(bright to CD56(dim lineage development.

Directory of Open Access Journals (Sweden)

Carolina Inés Domaica

Full Text Available Two populations of human natural killer (NK cells can be identified in peripheral blood. The majority are CD3(-CD56(dim cells while the minority exhibits a CD3(-CD56(bright phenotype. In vitro evidence indicates that CD56(bright cells are precursors of CD56(dim cells, but in vivo evidence is lacking. Here, we studied NK cells from a patient that suffered from a melanoma and opportunistic fungal infection during childhood. The patient exhibited a stable phenotype characterized by a reduction in the frequency of peripheral blood CD3(-CD56(dim NK cells, accompanied by an overt increase in the frequency and absolute number of CD3(-CD56(bright cells. These NK cells exhibited similar expression of perforin, CD57 and CD158, the major activating receptors CD16, NKp46, NKG2D, DNAM-1, and 2B4, as well as the inhibitory receptor CD94/NKG2A, on both CD56(bright and CD56(dim NK cells as healthy controls. Also, both NK cell subpopulations produced IFN-γ upon stimulation with cytokines, and CD3(-CD56(dim NK cells degranulated in response to cytokines or K562 cells. However, upon stimulation with cytokines, a substantial fraction of CD56(dim cells failed to up-regulate CD57 and CD158, showed a reduction in the percentage of CD16(+ cells, and CD56(bright cells did not down-regulate CD62L, suggesting that CD56(dim cells could not acquire a terminally differentiated phenotype and that CD56(bright cells exhibit a maturation defect that might result in a potential altered migration pattern. These observations, support the notion that NK cells of this patient display a maturation/activation defect that precludes the generation of mature NK cells at a normal rate accompanied by CD56(dim NK cells that cannot completely acquire a terminally differentiated phenotype. Thus, our results provide evidence that support the concept that in vivo CD56(bright NK cells differentiate into CD56(dim NK cells, and contribute to further understand human NK cell ontogeny.

Computer aided systems human engineering: A hypermedia tool

Science.gov (United States)

Boff, Kenneth R.; Monk, Donald L.; Cody, William J.

1992-01-01

The Computer Aided Systems Human Engineering (CASHE) system, Version 1.0, is a multimedia ergonomics database on CD-ROM for the Apple Macintosh II computer, being developed for use by human system designers, educators, and researchers. It will initially be available on CD-ROM and will allow users to access ergonomics data and models stored electronically as text, graphics, and audio. The CASHE CD-ROM, Version 1.0 will contain the Boff and Lincoln (1988) Engineering Data Compendium, MIL-STD-1472D and a unique, interactive simulation capability, the Perception and Performance Prototyper. Its features also include a specialized data retrieval, scaling, and analysis capability and the state of the art in information retrieval, browsing, and navigation.

IDC Reengineering Phase 2 & 3 Rough Order of Magnitude (ROM) Cost Estimate Summary (Leveraged NDC Case).

Energy Technology Data Exchange (ETDEWEB)

Harris, James M.; Prescott, Ryan; Dawson, Jericah M.; Huelskamp, Robert M.

2014-11-01

Sandia National Laboratories has prepared a ROM cost estimate for budgetary planning for the IDC Reengineering Phase 2 & 3 effort, based on leveraging a fully funded, Sandia executed NDC Modernization project. This report provides the ROM cost estimate and describes the methodology, assumptions, and cost model details used to create the ROM cost estimate. ROM Cost Estimate Disclaimer Contained herein is a Rough Order of Magnitude (ROM) cost estimate that has been provided to enable initial planning for this proposed project. This ROM cost estimate is submitted to facilitate informal discussions in relation to this project and is NOT intended to commit Sandia National Laboratories (Sandia) or its resources. Furthermore, as a Federally Funded Research and Development Center (FFRDC), Sandia must be compliant with the Anti-Deficiency Act and operate on a full-cost recovery basis. Therefore, while Sandia, in conjunction with the Sponsor, will use best judgment to execute work and to address the highest risks and most important issues in order to effectively manage within cost constraints, this ROM estimate and any subsequent approved cost estimates are on a 'full-cost recovery' basis. Thus, work can neither commence nor continue unless adequate funding has been accepted and certified by DOE.

Operating Experience with Nuclear Power Stations in Member States in 2011. 2012 Edition (CD-ROM)

International Nuclear Information System (INIS)

2012-08-01

This CD contains the 43rd edition of the IAEA's series of annual reports on operating experience with nuclear power plants in Member States. It is a direct output from the IAEA's Power Reactor Information System (PRIS) and contains information on electricity production and overall performance of individual operational plants during 2011. In addition to annual information, the report contains a historical summary of performance during the lifetime of individual plants and figures illustrating worldwide performance of the nuclear industry. The CD contains also an overview of design characteristics and dashboards of all operating nuclear power plants worldwide.

Intertekstualitāte Dž.K. Roulingas "Harija Potera" romānu serijā

OpenAIRE

Strunga-Raude, Aija

2009-01-01

Šī bakalaura darba tēma ir „Intertekstualitāte Dž. K. Roulingas "Harija Potera" romānu sērijā”. Es izvēlējos šo tēmu, jo 2008. gadā tika izdota pēdējā septītā grāmata šajā romānu sērijā un šīs grāmatas jau ir izraisījušas plašas diskusijas dažādās sabiedrības grupās. Šī ir lieliska iespēja izpētīt ko tieši Džoanna Ketlīna Roulinga ir izmantojusi savā romānā “Harijs Poters”. Šī darba mērķis ir ilustrēt kā Dž. K. Roulinga, rakstot „Harija Potera” romānu sēriju, ir izmantojusi intertekstualit...

[Five years of ROM in substance abuse treatment centres in the Netherlands].

Science.gov (United States)

Oudejans, S C C; Schippers, G M; Spits, M E; Stollenga, M; van den Brink, W

2012-01-01

Three substance abuse treatment centres set up a benchmarking project for routine outcome management (ROM) of structured cognitive behavioral treatments for outpatients with a substance use disorder. To present the results of five years benchmarking. All patients were included at intake and the follow-up assessment was performed by a call-center nine months later. Twice a year aggregated data were fed back to management and treatment teams. Since 2005, clinical outcome data, including substance abuse data, have been collected for more than half of all 15.786 treated patients. At follow-up, nine months after intake, 23% was abstinent, 28% reported moderate substance use and 49% reported excessive substance use. The Dutch centres for the treatment of substance abuse were successful in setting up ROM projects to monitor and compare the development and the effects of outpatient addiction treatments. The clinical results are acceptable and correspond to the results of the American project called match. It is not yet clear whether the biannual feedback of aggregated outcomes to management and treatment teams has contributed to the creation of learning organisations, but it has provided transparency and has made it possible for teams to learn from the outcomes.

AstroCappella: Songs of the Universe

Science.gov (United States)

Boyd, P. T.; Smale, A. P.; Smale, K. M.

2008-11-01

The AstroCappella Project is a classroom-ready collection of upbeat pop songs, lesson plans, and background information, all rich in science content. It was developed as a collaboration between working research astronomers, educators, and a contemporary vocal band, The Chromatics. A multimedia music CD, ``AstroCappella 2.0,'' has been produced containing 13 astronomically correct songs with original lyrics and music. Song topics range from the Sun, Moon, planets and small bodies of the Solar System, through the Doppler shift, the nearest stars, and extra-solar planets, to radio and X-ray astronomy. The CD also contains extensive CD-ROM materials including science background information, curriculum notes, lesson plans and activities for each song, images, movies, and slide shows. The songs and accompanying information have been extensively field-tested, and align to the K--12 National Science Education Standards. The AstroCappella materials are in widespread use in classrooms and homes across the U.S., and are supplemented with frequent live performances and teacher workshops.

Regional Ocean Modeling System (ROMS): Main Hawaiian Islands

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 7-day, 3-hourly forecast for the region surrounding the main Hawaiian islands at approximately 4-km resolution. While...

Regional Ocean Modeling System (ROMS): CNMI: Data Assimilating

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 3-day, 3-hourly data assimilating hindcast for the region surrounding the Commonwealth of the Northern Mariana Islands (CNMI)...

Regional Ocean Modeling System (ROMS): Samoa: Data Assimilating

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 3-day, 3-hourly data assimilating hindcast for the region surrounding the islands of Samoa at approximately 3-km resolution....

Regional Ocean Modeling System (ROMS): Oahu: Data Assimilating

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 2-day, 3-hourly data assimilating hindcast for the region surrounding the island of Oahu at approximately 1-km resolution....

CARA MUDAH MENYIAPKAN MATERI PEMBELAJARAN BERBASIS WEB DAN CD UNTUK BAHASA INDONESIA

Directory of Open Access Journals (Sweden)

Yusring Sanusi Baso

2015-04-01

Full Text Available Revolution of Information and Communication Technology (ICT has changed the various areas of human life, including the revolution in education. Revolution of education occurs since people migrate their way of learning from conventional to digital learning, face-to-face at a certain time and place into a meeting from anywhere and anytime. In the past we used paper, now we already headed to paperless era. Several years ago, teachers and lecturers is the source of knowledge, it is the source of knowledge can be through a variety of media, such as CD-ROMs and the Internet. The way we learn is change to distant learning with free study hour. Then, it results the term e-learning, knowledge server and knowledge based society. This article discusses how to prepare simple e-learning material (web and cd-based about Bahasa Indonesian. The program that employs to elaborate and modify the material is Hot Potatoes which is published by the University of Victoria and the Half-Baked Software. The material of Bahasa Indonesian use in this program is a set of questions on National Examination for Selection Admissions (SPMB. These questions will create an interactive multimedia material, especially web-based and CD-based material. Modules that are discussed in this article including input of data (questions, answers, etc., output configuration (modification of the display and apperance, as well as techniques to publish on the website. In addition, it will also discuss how to keep the material in the web and cd. The final result (output or material output from this program is the material that can be used as in learning Bahasa Indonesian, especially for self training and test. The Output will be in the form of website and CDs. Keywords: e-learning, Hot Potatoes, web and cd.

Patient-oriented presentation of results of radiological procedures using DICOM-compliant DVD media

Science.gov (United States)

Ratib, Osman M.; Aberle, Denise R.; Goldin, Jonathan G.; Lu, David S.; Dahlbom, Magdalena; McGill, D. Ric; McCoy, J. Michael

2003-05-01

Some institutions have adopted digital media such as CD ROMs to provide patients and referring physicians with results of radiological procedures. These systems require a computer to review the images and lack the supporting explanations and guidance for patients to properly understand the results. We developed a hybrid DVD encoding format that combines DICOM-compliant image storage format with video streams viewable on any consumer DVD players. The addition of the video material allows radiologists to provide explanations, disclaimers and guidance to the patients regarding the results of the study. The diagnostic report is also included on the DVD as a PDF file and as a set of video frames that can be viewed on a DVD player. The native high-resolution images are also included in DICOM format on the DVD and can be accessed by any workstation equipped with a DICOM viewer. The DVD that can be reviewed on any consumer DVD player overcomes the limitation of CD ROMS that require the use of a personal computer. The results of the radiological procedures become more accessible patients that could be reluctant or unable to use a computer. Also, live video clips add a more personalized note and allow radiologists to convey important messages to the patients. This is particularly useful for self-referred screening procedures where results should always be accompanied with education material and explanations of the findings.

Review of The Earl of Abergavenny. Historical Record and Wreck Excavation CD-Rom

OpenAIRE

David Petts

2003-01-01

In early February 1805 a small fleet of East Indiamen accompanied by the frigate Weymouth set sail from Portsmouth heading first for Bengal and ultimately for China. However, barely had the voyage began when, following bad weather and confusion, one of the boats, the Earl of Abergavenny, struck the Shambles bank just off Portland Bill. Although the crew managed to free it, it was so badly damaged it sank while trying to make for the safety of Weymouth. Over 250 crew and passengers drowned. Th...

A. Moerdijk en R. Tempelaars (redactie). Van A tot Z en verder ...

African Journals Online (AJOL)

rbr

op CD-ROM en elektroniese databasisse as redes vir sy optimistiese toekoms- perspektief. Volgens Moerdijk kan die leemtes wat in die gedrukte weergawe van die. WNT voorkom, aangevul word met die elektroniese weergawe wat in 1995 op. CD-ROM verskyn het. Deur gebruik te maak van die CD-ROM is aanvullende.

Impact of CD1d deficiency on metabolism.

Directory of Open Access Journals (Sweden)

Maya E Kotas

Full Text Available Invariant natural killer T cells (iNKTs are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d. Although capable of a myriad of responses, few essential functions have been described for iNKTs. Among the many cell types of the immune system implicated in metabolic control and disease, iNKTs seem ideally poised for such a role, yet little has been done to elucidate such a possible function. We hypothesized that lipid presentation by CD1d could report on metabolic status and engage iNKTs to regulate cellular lipid content through their various effector mechanisms. To test this hypothesis, we examined CD1d deficient mice in a variety of metabolically stressed paradigms including high fat feeding, choline-deficient feeding, fasting, and acute inflammation. CD1d deficiency led to a mild exacerbation of steatosis during high fat or choline-deficient feeding, accompanied by impaired hepatic glucose tolerance. Surprisingly, however, this phenotype was not observed in Jα18⁻/⁻ mice, which are deficient in iNKTs but express CD1d. Thus, CD1d appears to modulate some metabolic functions through an iNKT-independent mechanism.

Regional Ocean Modeling System (ROMS): Oahu South Shore

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 2-day, 3-hourly forecast for the region surrounding the south shore of the island of Oahu at approximately 200-m resolution....

Between Freedom and Constraint: ROM Hacking of Pokémon Games

OpenAIRE

Barnabé, Fanny

2018-01-01

This paper aims to study a creative practice widespread in video game cultures: “ROM hacking”. By examining with the tools of rhetoric a defined corpus of ROM hacks derived from 『Pokémon』 games, the presentation will show that the formal construction of these derivative works demonstrates less a free or subversive transformation than a fairly strict respect for the original games’ conventions. By reproducing the structure of official 『Pokémon 』games, these fan productions become mirrors revea...

Arquitectura románica en la provincia de Soria, 1856-2014. Marco historiográfico y metodológico

Directory of Open Access Journals (Sweden)

Lorenzo Arribas, Josemi

2014-12-01

Full Text Available The historiography of Romanesque in the province of Soria has three different stages. The former one begins with Eduardo Saavedra’s researches (1856 and it extends until 1934, when Gaya Nuño defends his PhD Thesis (La arquitectura románica en la provincia de Soria, which will not be published until 1946. The Spanish Civil War and the post-war period mark the beginning of the second stage, which is merely transitional, lacking any important contribution. The last stage begins with the publication of the three volumes of the Enciclopedia del Románico en Castilla y León (2002. These works have largely improved the knowledge of Romanesque architectural heritage, enhanced besides by the task undertaken by the technical office of the Cultural Project Soria Románica (2007- 2012, responsible for studying and restoring more than thirty Romanesque buildings in the Southern part of province. It is within this working frame that the building recording of the churches here presented must be understood. This historiographical assessment about provincial Romanesque does not include those buildings sited in the capital city, the Cathedral of El Burgo de Osma, the Monastery of Santa Maria de Huerta and the hermitage of San Baudelio (Casillas de Berlanga.La historiografía del Románico en la provincia de Soria tiene tres etapas diferenciadas. Una inicial, que parte de los estudios de Eduardo Saavedra (1856 y se extiende hasta 1934, fecha de la lectura de la tesis doctoral de Gaya Nuño (La arquitectura románica en la provincia de Soria, cuya publicación, no obstante, se demora hasta 1946. La Guerra Civil y posguerra marcan el comienzo de la segunda etapa, transicional y sin grandes aportaciones. La última etapa se inaugura con la publicación de los tres volúmenes sorianos de la Enciclopedia del Románico en Castilla y León (2002. Esta obra ha multiplicado el conocimiento del patrimonio edilicio románico, acrecentado, después, por la labor de la

Development and Utilization of Regional Oceanic Modeling System (ROMS) & Delicacy, Imprecision, and Uncertainty of Oceanic Simulations: An Investigation with ROMS

Science.gov (United States)

2010-09-30

and Ecosystems: An important community use for ROMS is biogeochemisty: chemical cycles, water quality, blooms , micro-nutrients, larval dispersal... Chile current system. J. Climate, submitted. Colas, F., X. Capet, and J. McWilliams, 2010b: Mesoscale eddy buoyancy flux and eddy-induced

Ģimene Mārgaretas Atvudas romānos

OpenAIRE

Voitiņa, Laura

2009-01-01

Mūsdienās diskusijas par ģimeni, tās vērtībām, mainīgo uzbūvi un problēmām, kas ietekmē šo institūtu, ir sastopamas ne tikai mutvārdu runā, bet arī rakstos. Dotā pētījuma mērķis bija veikt saturisku analīzi par ģimenes aprakstiem Margaretas Atvudas romānos “Istabenes Stāsts” un “Oriksa un Kreiks”, lai identificētu romānos aprakstītos ģimenes modeļus, vērtības, paražas un notikumus, kas ietekmē šo institūtu. Tika izmantotas gan teorētiskas, gan empīriskas pētījuma metodes. Lai sniegtu teorētis...

Reassignment of oxygen-related defects in CdTe and CdSe

Energy Technology Data Exchange (ETDEWEB)

Bastin, Dirk

2015-05-22

This thesis reassigns the O{sub Te}-V{sub Cd} complex in CdTe and the O{sub Se}-V{sub Cd} complex in CdSe to a sulfur-dioxygen complex SO{sub 2}*, and the O{sub Cd} defect in CdSe to a V{sub Cd}H{sub 2} complex using Fourier transformed infrared absorption spectroscopy. The publications of the previous complexes were investigated by theoreticians who performed first-principle calculations of theses complexes. The theoreticians ruled out the assignments and proposed alternative defects, instead. The discrepancy between the experimentally obtained and theoretically proposed defects was the motivation of this work. Two local vibrational modes located at 1096.8 (ν{sub 1}) and 1108.3 cm{sup -1} (ν{sub 2}) previously assigned to an O{sub Te}-V{sub Cd} complex are detected in CdTe single crystals doped with CdSO{sub 4} powder. Five weaker additional absorption lines accompanying ν{sub 1} and ν{sub 2} could be detected. The relative intensities of the absorption lines match a sulfur-dioxygen complex SO{sub 2}* having two configurations labeled ν{sub 1} and ν{sub 2}. A binding energy difference of 0.5±0.1 meV between the two configurations and an energy barrier of 53±4 meV separating the two configurations are determined. Uniaxial stress applied to the crystal leads to a splitting of the absorption lines which corresponds to an orthorhombic and monoclinic symmetry for ν{sub 1} and ν{sub 2}, respectively. In virgin and oxygen-doped CdSe single crystals, three local vibrational modes located at 1094.1 (γ{sub 1}), 1107.5 (γ{sub 2}), and 1126.3 cm{sup -1} (γ{sub 3}) previously attributed to an O{sub Se}-V{sub Cd} complex could be observed. The signals are accompanied by five weaker additional absorption features in their vicinity. The additional absorption lines are identified as isotope satellites of a sulfur-dioxygen complex SO{sub 2}* having three configurations γ{sub 1}, γ{sub 2}, and γ{sub 3}. IR absorption measurements with uniaxial stress applied to the

DISTANCE LEARNING AND ATTITUDES OF GREEK BASKETBALL COACHES

Directory of Open Access Journals (Sweden)

E. Tsamourtzis

2009-01-01

Full Text Available Aim of the present research was the determination of the attitudes of Greek Basketball coaches towards their distance learning with the use of ICT in comparison with the classical learning and the examination of the perspective of their distance learning with the use of ICT. Therefore a closed questionnaire was used which included 3 different parts. 60 basketball coaches from Northern Greece comprised the sample (N=60. An interactive software was created which included the teaching of an offensive basketball system. The methodology of distance learning was used for the creation of the offensive system. The software was copied to a CD-Rom and accompanied with the questionnaires it was given to 20 Basketball coaches of Northern Greece as a pilot program. After the corrections of the primary questionnaires, the distribution of the final questionnaire accompanied with the CD-Rom followed. Multiple reciprocations were used for the data analysis. According to the results the more relaxing, easier and faster distance learning was considered in relation to the conventional one, a the fewer difficulties would the Basketball coaches face by using the distance learning method and b the friendlier and more relaxing would the distance learning method be. Also according to data research: a the more attractive the reading of software was, b the fewer the difficulties during the reading of software and c the more relaxing, easier and faster distance learning was considered in relation to the conventional one, the stronger was the perspective of Basketball coaches to believe in distance learning. In conclusion the more relaxing, easier and faster distance learning was considered in relation to the conventional one, the more positive were the attitudes of Basketball coaches towards their distance learning, while a positive perspective of Basketball coaches towards their distance learning is being formed.

Lineage determination of CD7+ CD5- CD2- and CD7+ CD5+ CD2- lymphoblasts: studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta.

Science.gov (United States)

Yoneda, N; Tatsumi, E; Teshigawara, K; Nagata, S; Nagano, T; Kishimoto, Y; Kimura, T; Yasunaga, K; Yamaguchi, N

1994-04-01

The gene expression of myeloperoxidase (MPO), CD3 epsilon, and CD3 delta molecules, the gene rearrangement of T-cell receptor (TCR) delta, gamma, and beta and immunoglobulin heavy (IgH) chain, and the expression of cell-surface antigens were investigated in seven cases of CD7+ CD5- CD2- and four cases of CD7+ CD5+ CD2- acute lymphoblastic leukemia or lymphoblastic lymphoma (ALL/LBL) blasts, which were negative for cytochemical myeloperoxidase (cyMPO). More mature T-lineage blasts were also investigated in a comparative manner. In conclusion, the CD7+ CD5- CD2- blasts included four categories: undifferentiated blasts without lineage commitment, T-lineage blasts, T-/myeloid lineage blasts, and cyMPO-negative myeloblasts. The CD7+ CD5+ CD2- blasts included two categories; T-lineage and T-/myeloid lineage blasts. The 11 cases were of the germ-line gene (G) for TCR beta and IgH. Four cases were G for TCR delta and TCR gamma. The others were of the monoclonally rearranged gene (R) for TCR delta and G for TCR gamma or R for both TCR delta and TCR gamma. The expression or in vitro induction of CD13 and/or CD33 antigens correlated with the immaturity of these neoplastic T cells, since it was observed in all 11 CD7+ CD5- CD2- and CD7+ CD5+ CD2-, and some CD7+ CD5+ CD2+ (CD3- CD4- CD8-) cases, but not in CD3 +/- CD4+ CD8+ or CD3+ CD4+ CD8- cases. CD3 epsilon mRNA, but not CD3 delta mRNA, was detected in two CD7+ CD5- CD2- cases, while mRNA of neither of the two CD3 molecules was detected in the other tested CD7+ CD5- CD2- cases. In contrast, mRNA of both CD3 epsilon and CD3 delta were detected in all CD7+ CD5+ CD2- cases, indicating that CD7+ CD5- CD2- blasts at least belong to T-lineage. The blasts of two CD7+ CD5- CD2- cases with entire germ-line genes and without mRNA of the three molecules (MPO, CD3 epsilon, and CD3 delta) were regarded as being at an undifferentiated stage prior to their commitment to either T- or myeloid-lineage. The co-expression of the genes of MPO

En teoretisk utdyping av rom og materialitet som pedagogisk ressurs i barnehagen

Directory of Open Access Journals (Sweden)

Solveig Nordtømme

2015-07-01

Full Text Available Abstract: This article is a theoretical exploration with the aim of discussing an ontological basis for space and materiality as educational resources in kindergarten. Attention is directed on children’s play experiences interacting with space and materiality, and how children use and create space. The metaphors front stage, space in between, and backstage (inspired from Erving Goffman, 1969, which form the study's main findings, are used as the backdrop for the issue and analyzes. The empirical material used in this exploration has been collected with an ethnographic methodological approach in two kindergartens. Maurice Merleau-Ponty’s (1962 focus on bodily experience and presence in space, along with concepts from Latour’s (2005 actor-network theory, is used to explore the data. The article contributes with theoretical tools for professionals in kindergarten teaching, to shed light on the importance of space, materiality and play in children's everyday life in kindergarten.Sammendrag: Denne artikkelen diskuterer et ontologisk grunnlag og er en teoretisk utforskning av rom og materialitet som en pedagogisk ressurs i barnehagen. Oppmerksomheten er rettet mot barns lekeerfaringer i samspill med rom og materialitet, og hvordan barn bruker og skaper rom. Metaforene hovedrom, mellomrom, og bakrom (inspirert fra Erving Goffman, 1969, som danner studiens hovedfunn, blir brukt som et bakteppe for problemstilling og analyser av det empiriske materialet fra to barnehager. Maurice Merleau-Ponty publikasjoner The Phenomenology of Perception (Merleau-Ponty, 1962 med sitt fokus på kroppslig erfaring i levd rom, blir brukt sammen med begreper fra Latours aktør-nettverksteori (Latour 2005 til å utforske hvordan rom og materialitet kan være pedagogiske ressurser. Artikkelens kunnskapsbidrag er å presentere et teoretisk verktøy for barnehageprofesjonen og kunnskaper om lekens betydning i barns hverdag i barnehagen.

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

Directory of Open Access Journals (Sweden)

Nicholas Jones

2017-11-01

Full Text Available Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4+ and CD8+ T-cells are controlled by the strength of interaction between the T-cell receptor (TCR and peptides presented by human leukocyte antigens (pHLA. The role of TCR–pHLA interactions in modulating T-cell metabolism is unknown. Here, for the first time, we explore the relative contributions of the main metabolic pathways to functional responses in human CD4+ and CD8+ T-cells. Increased expression of hexokinase II accompanied by higher basal glycolysis is demonstrated in CD4+ T-cells; cytokine production in CD8+ T-cells is more reliant on oxidative phosphorylation. Using antigen-specific CD4+ and CD8+ T-cell clones and altered peptide ligands, we demonstrate that binding affinity tunes the underlying metabolic shift. Overall, this study provides important new insight into how metabolic pathways are controlled during antigen-specific activation of human T-cells.

Volcanoes of the Wrangell Mountains and Cook Inlet region, Alaska: selected photographs

Science.gov (United States)

Neal, Christina A.; McGimsey, Robert G.; Diggles, Michael F.

2001-01-01

Alaska is home to more than 40 active volcanoes, many of which have erupted violently and repeatedly in the last 200 years. This CD-ROM contains 97 digitized color 35-mm images which represent a small fraction of thousands of photographs taken by Alaska Volcano Observatory scientists, other researchers, and private citizens. The photographs were selected to portray Alaska's volcanoes, to document recent eruptive activity, and to illustrate the range of volcanic phenomena observed in Alaska. These images are for use by the interested public, multimedia producers, desktop publishers, and the high-end printing industry. The digital images are stored in the 'images' folder and can be read across Macintosh, Windows, DOS, OS/2, SGI, and UNIX platforms with applications that can read JPG (JPEG - Joint Photographic Experts Group format) or PCD (Kodak's PhotoCD (YCC) format) files. Throughout this publication, the image numbers match among the file names, figure captions, thumbnail labels, and other references. Also included on this CD-ROM are Windows and Macintosh viewers and engines for keyword searches (Adobe Acrobat Reader with Search). At the time of this publication, Kodak's policy on the distribution of color-management files is still unresolved, and so none is included on this CD-ROM. However, using the Universal Ektachrome or Universal Kodachrome transforms found in your software will provide excellent color. In addition to PhotoCD (PCD) files, this CD-ROM contains large (14.2'x19.5') and small (4'x6') screen-resolution (72 dots per inch; dpi) images in JPEG format. These undergo downsizing and compression relative to the PhotoCD images.

The Application of a Modified d-ROMs Test for Measurement of Oxidative Stress and Oxidized High-Density Lipoprotein

Directory of Open Access Journals (Sweden)

Fumiaki Ito

2017-02-01

Full Text Available Reactive oxygen species (ROS are involved in the initiation and progression of atherosclerosis. ROS-derived hydroperoxides, as an indicator of ROS production, have been measured by using the diacron reactive oxygen metabolites (d-ROMs test, which requires iron-containing transferrin in the reaction mixture. In this study we developed a modified d-ROMs test, termed the Fe-ROMs test, where iron ions were exogenously added to the reaction mixture. This modification is expected to exclude the assay variation that comes from different blood iron levels in individuals. In addition, this Fe-ROMs test was helpful for determining the class of plasma lipoproteins that are hydroperoxidized. Low-density lipoprotein/very low-density lipoprotein (LDL/VLDL and high-density lipoprotein (HDL were purified by use of an LDL/VLDL purification kit and the dextran sulfate-Mg2+ precipitation method, respectively; their hydroperoxide contents were assessed by performing the Fe-ROMs test. The majority of the hydroperoxides were detected only in the HDL fraction, not in the LDL/VLDL. Further detailed analysis of HDLs by size-exclusion high-performance liquid chromatography revealed that the hydroperoxide-containing molecules were small-sized HDLs. Because HDL was shown to be the principal vehicle for the plasma hydroperoxides, this Fe-ROMs test is a beneficial method for the assessment of oxidized-HDL levels. Indeed, Fe-ROMs levels were strongly associated with the levels of oxidized HDL, which were determined by performing the malondialdehyde-modified HDL enzyme immunoassay. In conclusion, the Fe-ROMs test using plasma itself or the HDL fraction after dextran sulfate-Mg2+ precipitation is useful to assess the functionality of HDL, because the oxidation of HDL impairs its antiatherogenic capacity.

Manufacturing process of rewritable CD and DVD; Kakikae gata CD, DVD no seizo process

Energy Technology Data Exchange (ETDEWEB)

Horie, M. [Mitsubishi Chemical Corp., Tokyo (Japan)

1998-11-05

Development of rewritable DVD is desired which has feedback compatibility with the existing players and ROM drives. The DVD is formed on a substrate with a thickness of 0.6 mm (dummy plate), and is composed of the multilayer film, i.e., protective coating made of UV hardening resin, reflective layer, dielectric protective layer, phase change type recording layer, and polycarbonate layer from the lower in order. A pair of dummy plates are pasted to enhance the mechanical strength, which has the same thickness of 1.2 mm as CD. Since the grooves and prepits are very fine, injection molding is more difficult compared with CD. Since a great stress change occurs during the formation and initialization processes of multilayer of phase change recording medium layer which is particular to DVD manufacturing process, control of warping is significant. Control of warping of the substrate is also significant, which affects the pasting and the whole process. The recording layer, dielectric protective layer and reflective layer are formed by the discharge spattering. The initialization is a particular process to the phase change medium. Complete non-recording state can be obtained by crystallizing the amorphous recording layer after the film formation. 3 figs.

Abstracts of the Canadian Society for Civil Engineering annual conference including the general conference, the 1. international structural specialty conference, the 1. international construction specialty conference, and the 1. specialty conference on disaster mitigation : towards a sustainable future

International Nuclear Information System (INIS)

El-Badry, M.; Loov, R.E.; Ruwanpura, J.; El-Hacha, R.; Kroman, J.; Rankin, J.

2006-01-01

This conference provided a forum for national and international practicing engineers, researchers and technical experts to discuss sustainable solutions to infrastructure development. Discussions focused on recent developments in new technologies for building more economic and sustainable infrastructure, while improving the safety of buildings, bridges, roads, water supply and sewage treatment systems. The conference was held in conjunction with associated specialty conferences, including a first international structures specialty conference, a first international construction specialty conference, and a first specialty conference on disaster mitigation. This book of abstracts highlights all the specialty conferences and accompanies a CD-ROM that has the full text of all the papers. Manuscripts of the full papers submitted to the specialty conferences were peer-reviewed by international scientific committees. The general conference provided a forum to learn about new technologies and future directions in various areas of civil engineering. It included a special theme session on sustainable development and a special session on innovation and information technology. Other technical sessions focused on topics such as civil engineering history and education; infrastructure management and renewal; asset management; risk assessment and management; engineering materials and mechanics; environmental engineering and science; hydrotechnical engineering; cold region engineering; and, transportation engineering. The general conference featured 88 presentations, of which 15 have been catalogued separately for inclusion in this database

Adolescencia, relaciones románticas y actividad sexual: una revisión

OpenAIRE

Vargas Trujillo, Elvia; Barrera, Fernando

2008-01-01

Se presenta una revisión de algunas de las investigaciones más recientes sobre la adolescencia y los factores asociados a las relaciones románticas y la actividad sexual durante la adolescencia. Se parte de la premisa de que el análisis de la iniciación romántica y sexual durante la adolescencia requiere de modelos de causalidad múltiple que permitan dar cuenta, conjuntamente, de los factores que se encuentran en los contextos individual, familiar y social asociados con estos dos procesos. Se...

Experimental study on x-rays dose enhancement effects for floating gate ROMs

CERN Document Server

Guo Hong Xia; Chen Yu Sheng; Han Fu Bin; He Chao Hui; Zhao Hui

2002-01-01

Experimental results of x-ray dose enhancement effects are given for floating gate read-only memory (ROMs) irradiated in the Beijing Synchrotron Radiation Facility. The wrong byte numbers vs. total irradiation dose have been tested and the equivalent relation of total dose damage is provided compared the response of devices irradiated with sup 6 sup 0 Co gamma-ray source. The x-ray dose enhancement factors for floating gate ROMs are obtained firstly in China. These results can be an effective evaluation data for x-rays radiation hardening technology

Upregulation of CD19⁺CD24(hi)CD38(hi) regulatory B cells is associated with a reduced risk of acute lung injury in elderly pneumonia patients.

Science.gov (United States)

Song, Haihan; Xi, Jianjun; Li, Guang-Gang; Xu, Shumin; Wang, Chunmei; Cheng, Tingting; Li, Hongqiang; Zhang, Ying; Liu, Xiandong; Bai, Jianwen

2016-04-01

Acute lung injury (ALI) is a common complication in elderly pneumonia patients who have a rapid progression, and is accompanied by a high mortality rate. Because the treatment options of ALI are limited to supportive care, identifying pneumonia patients who are at higher risk of ALI development is the emphasis of many studies. Here, we approach this problem from an immunological perspective by examining CD19(+)CD24(hi)CD38(hi) B cells, an important participant in acute and chronic inflammation. We find that elderly pneumonia patients have elevated CD19(+)CD24(hi)CD38(hi) B cell frequency compared to healthy individuals. This B cell population may express a higher level of IL-10, which has been was shown to suppress CD4(+) T cell-mediated proinflammatory cytokine interferon gamma (IFNg) and tumor necrosis factor alpha (TNFa) production, through an IL-10-dependent mechanism. We also observe that the frequency of CD19(+)CD24(hi)CD38(hi) B cell is positively correlated with the frequency of CD4(+)CD25(+)Foxp3(+)Tregs in peripheral blood. Moreover, consistent with CD19(+)CD24(hi)CD38(hi) B cell's anti-inflammatory role, we find that pneumonia patients who later developed ALI have reduced level of CD19(+)CD24(hi)CD38(hi) B cells. Together, our results demonstrated that CD19(+)CD24(hi)CD38(hi) B cells in pneumonia patients possess regulatory function in vivo, and are associated with a reduced ALI risk.

Regional Ocean Modeling System (ROMS): Main Hawaiian Islands: Data Assimilating

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 3-day, 3-hourly data assimilating hindcast for the region surrounding the main Hawaiian islands at approximately 4-km...

[Evaluation of percentage of lymphocytes B with expression of co-receptors CD 40, CD22 and CD72 in hypertrophied adenoid at children with otitis media with effusion].

Science.gov (United States)

Wysocka, Jolanta; Zelazowska-Rutkowska, Beata; Ratomski, Karol; Skotnicka, Bozena; Hassmann-Poznańska, Elzbieta

2009-01-01

In hypertrophied adenoid lymphocytes B make up about 60% all lymphocytes. When the lymphocytes B come in interaction with antigens this membranes signal be passed through their receptor (BCR) to interior of cell. This signal affect modulation on gene expression, activation from which depends activation, anergy or apoptosis of lymphocyte B. Accompany BCR co-receptors regulate his functions influence stimulate or inhibitive. To the most important co-receptors stepping out on lymphocyte B belong: CD40, CD22, CD72. The aim of study was evaluation of lymphocytes B (CD19) with co-expression with CD72 and CD40 receptors in hypertrophied adenoid with at children with otitis media with effusion. An investigation was executed in hypertrophied adenoids with or without otitis media with effusion. By flow cytometry percentage of lymphocytes B with co-receptors CD 40, CD22 and CD72 in was analyzed. The percentages of CD19+CD72+ lymphocytes in the group of children with adenoid hypertrophy and exudative otitis media were lower as compared to the reference group. However, the percentages of CD19+CD22+, CD19+CD40+ in the study group was approximate to the reference group. The lower percentage of lymphocytes B CD72 + near approximate percentages of lymphocytes B CD40+ and BCD22+ at children with otitis media with effusion can be the cause of incorrect humoral response in hypertrophied adenoid at children. Maybe it is cause reduced spontaneous production IgA and IgG through lymphocyte at children with otitis media with effusion.

A multimedia package for particle technology

International Nuclear Information System (INIS)

Mathers, B.; Rhodes, M.; Iveson, S.

2002-01-01

A CD-ROM-based package is being prepared for Particle Technology education. It is based on the textbook 'Introduction to Particle Technology' by Martin Rhodes, and aims to expand on the information given in the text by making best possible use of the advantages offered by the CD-ROM format, including use of videos, animations and interactive functions. The CD-ROM will be divided into the same twelve sections as the text. Each section will have subsections of: 1) Industrial Relevance (showing a video and/or photos and explanation of how the subject matter is used in industry). 2) Experiment/Demonstration (a video where measurements can be taken by the user, or explanatory video and raw data provided. The user will be given directions on how to carry out the experiment and the necessary calculations). 3) Quiz (multiple choice format testing the knowledge gained in the previous sections). 4) Calculators (allowing the user to easily make important particle technology calculations) The CD-ROM will allow users the opportunity to observe particulate processes and operations without the necessity of participating in laboratories or site visits, and will therefore be a useful tool for distance education, for users learning on an individual basis or as an addition to institutionally based particle technology courses

Tidal simulation using regional ocean modeling systems (ROMS)

Science.gov (United States)

Wang, Xiaochun; Chao, Yi; Li, Zhijin; Dong, Changming; Farrara, John; McWilliams, James C.; Shum, C. K.; Wang, Yu; Matsumoto, Koji; Rosenfeld, Leslie K.;

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

International Nuclear Information System (INIS)

Fukui, Toshiki; Yamauchi, Kazuhiro; Maruyama, Mie; Yasuda, Tadashi; Abe, Youichi; Kohno, Masakazu

2011-01-01

In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this study, we investigated the association between the derivatives of reactive oxygen metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), and biological antioxidant potential (BAP), as an index of antioxidant potential. We also investigated the associations between d-ROMs or BAP and the risk factors for lifestyle-related diseases or metabolic syndrome-associated factors to evaluate their usefulness in preventive medicine. There were 442 subjects who underwent health checkup examination in our facilities. In addition to standard medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) visualized on a computed tomography scan. The mean d-ROM value in females was significantly higher than that in males. There was a positive correlation between the d-ROM and VFA levels. On correlation analysis, there was a negative correlation between the d-ROM and creatinine levels. As factors that influence d-ROMs, the level of VFA was selected, suggesting the significance of oxidative stress measurement with d-ROMs. In addition, there was a positive correlation between d-ROMs and BAP values. Further research is required to resolve whether increased production of ROS or the antioxidant potential that can compensate for such an increase of ROS is more important in vivo. (author)

Alois Riegl, Die Entstehung der Barockkunst in Rom, 1908

NARCIS (Netherlands)

Witte, A.; Bacchi, A.; Barroero, L.

2017-01-01

In 1908, Alois Riegl's unfinished text on the Italian Baroque was published by Max Dvorak and Arthur Burda; they edited part of his notes for three consecutive series of lectures at Vienna University. Riegl's book title aply reads Entstehung der Barockkunst in Rom: Akademische Vorlesungen and deals

Proceedings of the 4th European conference on protection against radon at home and at work. Conference programme and session presentations

International Nuclear Information System (INIS)

2004-01-01

The conference was divided into 6 sections as follows (the numbers of PDF files included in the CD-ROM are given in parentheses): 1. Radon measurement in dwellings (7); 2. Radon measurement at workplaces (14); 3. Methods of measurement and devices (16); 4. Remedial measures and techniques (5); 5. Preventive measures and techniques (10); and 6. National radon programmes (6). In addition, the CD-ROM contains 3, 11, 9, 5, 6, and 6 PowerPoint presentations shown in the six sections, respectively, plus a total of 93 abstracts, mostly of posters. (P.A.)

Reassignment of oxygen-related defects in CdTe and CdSe

International Nuclear Information System (INIS)

Bastin, Dirk

2015-01-01

This thesis reassigns the O_T_e-V_C_d complex in CdTe and the O_S_e-V_C_d complex in CdSe to a sulfur-dioxygen complex SO_2*, and the O_C_d defect in CdSe to a V_C_dH_2 complex using Fourier transformed infrared absorption spectroscopy. The publications of the previous complexes were investigated by theoreticians who performed first-principle calculations of theses complexes. The theoreticians ruled out the assignments and proposed alternative defects, instead. The discrepancy between the experimentally obtained and theoretically proposed defects was the motivation of this work. Two local vibrational modes located at 1096.8 (ν_1) and 1108.3 cm"-"1 (ν_2) previously assigned to an O_T_e-V_C_d complex are detected in CdTe single crystals doped with CdSO_4 powder. Five weaker additional absorption lines accompanying ν_1 and ν_2 could be detected. The relative intensities of the absorption lines match a sulfur-dioxygen complex SO_2* having two configurations labeled ν_1 and ν_2. A binding energy difference of 0.5±0.1 meV between the two configurations and an energy barrier of 53±4 meV separating the two configurations are determined. Uniaxial stress applied to the crystal leads to a splitting of the absorption lines which corresponds to an orthorhombic and monoclinic symmetry for ν_1 and ν_2, respectively. In virgin and oxygen-doped CdSe single crystals, three local vibrational modes located at 1094.1 (γ_1), 1107.5 (γ_2), and 1126.3 cm"-"1 (γ_3) previously attributed to an O_S_e-V_C_d complex could be observed. The signals are accompanied by five weaker additional absorption features in their vicinity. The additional absorption lines are identified as isotope satellites of a sulfur-dioxygen complex SO_2* having three configurations γ_1, γ_2, and γ_3. IR absorption measurements with uniaxial stress applied to the CdSe crystal yield a monoclinic C_1_h symmetry for γ_1 and γ_2. The SO_2* complex is stable up to 600 C. This thesis assigns the ν-lines in

Acceptability and preliminary feasibility of an internet/CD-ROM-based education and decision program for early-stage prostate cancer patients: randomized pilot study.

Science.gov (United States)

Diefenbach, Michael A; Mohamed, Nihal E; Butz, Brian P; Bar-Chama, Natan; Stock, Richard; Cesaretti, Jamie; Hassan, Waleed; Samadi, David; Hall, Simon J

2012-01-13

Prostate cancer is the most common cancer affecting men in the United States. Management options for localized disease exist, yet an evidence-based criterion standard for treatment still has to emerge. Although 5-year survival rates approach 98%, all treatment options carry the possibility for significant side effects, such as erectile dysfunction and urinary incontinence. It is therefore recommended that patients be actively involved in the treatment decision process. We have developed an Internet/CD-ROM-based multimedia Prostate Interactive Educational System (PIES) to enhance patients' treatment decision making. PIES virtually mirrors a health center to provide patients with information about prostate cancer and its treatment through an intuitive interface, using videos, animations, graphics, and texts. (1) To examine the acceptability and feasibility of the PIES intervention and to report preliminary outcomes of the program in a pilot trial among patients with a new prostate cancer diagnosis, and (2) to explore the potential impact of tailoring PIES treatment information to participants' information-seeking styles on study outcomes. Participants (n = 72) were patients with newly diagnosed localized prostate cancer who had not made a treatment decision. Patients were randomly assigned to 3 experimental conditions: (1) control condition (providing information through standard National Cancer Institute brochures; 26%), and PIES (2) with tailoring (43%) and (3) without tailoring to a patient's information-seeking style (31%). Questionnaires were administrated before (t1) and immediately after the intervention (t2). Measurements include evaluation and acceptability of the PIES intervention, monitoring/blunting information-seeking style, psychological distress, and decision-related variables (eg, decisional confidence, feeling informed about prostate cancer and treatment, and treatment preference). The PIES program was well accepted by patients and did not interfere

ROMS/TOMS Tangent Linear and Adjoint Models: Testing and Applications

National Research Council Canada - National Science Library

Miller, Arthur J; Cornuelle, Bruce D

2004-01-01

... (Regional Ocean Modeling System/Terrain-Following Ocean Modeling System) that is suitable for general use by the ROMS/TOMS community and to develop computational platforms based on the TLM and ADM for 4D variational data assimilation (4DVar...

The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype.

Science.gov (United States)

Munier, C Mee Ling; van Bockel, David; Bailey, Michelle; Ip, Susanna; Xu, Yin; Alcantara, Sheilajen; Liu, Sue Min; Denyer, Gareth; Kaplan, Warren; Suzuki, Kazuo; Croft, Nathan; Purcell, Anthony; Tscharke, David; Cooper, David A; Kent, Stephen J; Zaunders, John J; Kelleher, Anthony D

2016-10-17

Smallpox was eradicated by a global program of inoculation with Vaccinia virus (VV). Robust VV-specific CD4 T-cell responses during primary infection are likely essential to controlling VV replication. Although there is increasing interest in cytolytic CD4 T-cells across many viral infections, the importance of these cells during acute VV infection is unclear. We undertook a detailed functional and genetic characterization of CD4 T-cells during acute VV-infection of humans. VV-specific T-cells were identified by up-regulation of activation markers directly ex vivo and through cytokine and co-stimulatory molecule expression. At day-13-post primary inoculation with VV, CD38highCD45RO+ CD4 T-cells were purified by cell sorting, RNA isolated and analysed by microarray. Differential expression of up-regulated genes in activated CD4 T-cells was confirmed at the mRNA and protein levels. We compared analyses of VV-specific CD4 T-cells to studies on 12 subjects with primary HIV infection (PHI). VV-specific T-cells lines were established from PBMCs collected post vaccination and checked for cytotoxicity potential. A median 11.9% CD4 T-cells were CD38highCD45RO+ at day-13 post-VV inoculation, compared to 3.0% prior and 10.4% during PHI. Activated CD4 T-cells had an up-regulation of genes related to cytolytic function, including granzymes K and A, perforin, granulysin, TIA-1, and Rab27a. No difference was seen between CD4 T-cell expression of perforin or TIA-1 to VV and PHI, however granzyme k was more dominant in the VV response. At 25:1 effector to target ratio, two VV-specific T-cell lines exhibited 62% and 30% cytotoxicity respectively and CD107a degranulation. We show for the first time that CD4 CTL are prominent in the early response to VV. Understanding the role of CD4 CTL in the generation of an effective anti-viral memory may help develop more effective vaccines for diseases such as HIV. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

The Correlation of Exercise and Range of Motion (ROM on Elderly Knee Observasional Study on Elderly People in Pedurungan Semarang

Directory of Open Access Journals (Sweden)

Adhitya Putra Widyantoro

2012-06-01

Design and Method: Observastional study with a cross sectional design 80 elderly men and women were divided into 2 groups: gymnastics group in the Social Rehabilitation Unit Of Pucang Gading (n=40 and unexcercises group in the Penggaron village (n=40. In both groups, the degree of ROM of knee was assessed using the Goniometer. To evaluate the value of its significance, the data were analyzed using the Mann Withney test followed by Spearmann’s rho test. Result: ROM for gymnastic(exercised group and unexercised group were 115.50°±11.591°, 95.38°±12.780° respectively with p<0. 001. Resuts showed that doing exercise was useful for maintaining ROM of knee in elderly people. Spearmann’s rho test resulted in a strong correlation between ROM and exercise with r value of 0.652. Conclusion: exercise correlates with ROM of knee in elderly (Sains Medika, 4(1:39-45.

Highly active antiretroviral therapy including protease inhibitors does not confer a unique CD4 cell benefit. The AVANTI and INCAS Study Groups.

Science.gov (United States)

2000-07-07

To determine if triple combination therapy, particularly including HIV protease inhibitors (PI), confers an unique immunological benefit that is independent of reductions of plasma viral load (pVL). The correlation between changes from baseline in CD4 cell count and pVL was examined at all time points up to 52 weeks in three randomized clinical trials (AVANTI-2, AVANTI-3 and INCAS) that compared dual nucleoside therapy with triple combination therapy. Individual pVL and CD4 cell counts changes from baseline were entered into multivariate linear regression models for patients receiving double therapy and for those receiving triple therapy including a PI and/or a non-nucleoside reverse transcriptase inhibitor (NNRTI), and the null hypothesis was tested. After 52 weeks of therapy, the relationship between changes from baseline CD4 cell count and pVL was independent of whether patients were assigned double or triple therapy (P = 0.23 and 0.69 for intercept and slope, respectively), or whether patients were assigned triple therapy including a PI or triple therapy including an NNRTI (P = 0.92 and 0.95, respectively). Less than 5% of patients ever had 'discordant' increases in both CD4 cell count and pVL compared with baseline, and this proportion was unrelated to the class of therapy used. 'Discordant' decreases from baseline in both parameters were observed in up to 35% of individuals. The correlation between pVL and CD4 cell count changes from baseline improved over time on therapy, regardless of the therapeutic regimen involved. The data provide no evidence for a CD4 cell count benefit of highly active antiretroviral therapy (HAART) unique to triple therapy or PI-containing regimens.

Importance of N-Glycosylation on CD147 for Its Biological Functions

Science.gov (United States)

Bai, Yang; Huang, Wan; Ma, Li-Tian; Jiang, Jian-Li; Chen, Zhi-Nan

2014-01-01

Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans. Finally, we discuss proteins regulating CD147 glycosylation and the biological functions of CD147 glycosylation. PMID:24739808

Importance of N-Glycosylation on CD147 for Its Biological Functions

Directory of Open Access Journals (Sweden)

Yang Bai

2014-04-01

Full Text Available Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans. Finally, we discuss proteins regulating CD147 glycosylation and the biological functions of CD147 glycosylation.

Thirteenth Joint European and National Astronomical Meeting

CERN Document Server

Iniesta, J C

2006-01-01

The book gathers the invited talks to the XIII JENAM conference, organized this time by the European Astronomical Society (EAS) and the Spanish Astronomical Society (SEA), and hosted by the Instituto de Astrofísica de Andalucía (CSIC). All branches of astrophysics are encompassed from the largest scales and cosmology to the solar system and the Sun, through the galaxies and the stars, including a section on astronomical instrumentation. Very relevant experts from all over the world speak in a single book about the most recent, exciting results from their fields in a way which is useful for both researchers in these fields and colleagues working in other disciplines. The book is accompanied by a CD-ROM including the remaining contributions of the meeting in PDF format, hence opening a wide panorama of what is going on in astrophysics nowadays.

Virtual reality in Latin American clinical psychology and the VREPAR project. Virtual Reality Environments for Psycho-Neuro-physiological Assessment and Rehabilitation.

Science.gov (United States)

Silva, Mauro Rubens

2002-10-01

Starting with the excellent collective work done by the European Community (EC)-funded Virtual Reality Environments for Psycho-Neuro-physiological Assessment and Rehabilitation (VREPAR) projects, I try to indicate some possible pathways that would allow a better integration of this advanced technology into the reality of Latin American psychology. I myself use analyses that I did in my master's degree in the PUCSP-Catholic University in São Paulo, Brazil. I also include a brief description of the CD-ROM Clinical Psychology Uses of Virtual Reality (CPUVR) that accompanies my thesis. I point out the importance of collaboration between psychology and other disciplines, including computer science. I explain the method that I used to work with digital information, important for the formation of a critical mass of people thinking in Portuguese and Spanish to accelerate a technological jump.

Development and Utilization of Regional Oceanic Modeling System (ROMS). Delicacy, Imprecision, and Uncertainty of Oceanic Simulations: An Investigation with the Regional Oceanic Modeling System (ROMS). Mixing in the Ocean Surface Layer Using the Regional Oceanic Modeling System (ROMS).

Science.gov (United States)

2011-09-30

community use for ROMS is biogeochemisty: chemical cycles, water quality, blooms , micro-nutrients, larval dispersal, biome transitions, and coupling to...J.C. McWilliams, X. Capet, and J. Kurian, 2010: Heat balance and eddies in the Peru- Chile Current System. Climate Dynamics, 37, in press. doi10.1007

Biblioteca Naţională a României: obiective şi perspective în valorificarea patrimoniului cultural

Directory of Open Access Journals (Sweden)

Elena Tîrziman

2008-01-01

Biblioteca Naţională a României este implicată în proiecte internaţionale care au ca scop crearea de conţinut digital relevant pentru memoria culturală europeană: The European Library – TEL (Biblioteca europeană, Manuscriptorium şi ENRICH – European Networking Resources and Information concerning Cultural Heritage, proiecte coordonate de Biblioteca Naţională a Cehiei. Biblioteca Naţională a României a contribuit la proiectele Manuscriptorium / ENRICH prin carte românească veche din perioada corespunzătoare secolelor XVI-XVII.

Attention Novices: Friendly Intro to Shiny Disks.

Science.gov (United States)

Bardes, D'Ellen

1986-01-01

Provides an overview of how optical storage technologies--videodisk, Write-Once disks, and CD-ROM CD-I disks are built into and controlled via DEC, Apple, Atari, Amiga, and IBM PC compatible microcomputers. Several available products are noted and a list of producers is included. (EM)

Effects of CD44 Ligation on Signaling and Metabolic Pathways in Acute Myeloid Leukemia

KAUST Repository

Madhoun, Nour Y.

2017-04-01

Acute myeloid leukemia (AML) is characterized by a blockage in the differentiation of myeloid cells at different stages. CD44-ligation using anti-CD44 monoclonal antibodies (mAbs) has been shown to reverse the blockage of differentiation and to inhibit the proliferation of blasts in most AML-subtypes. However, the molecular mechanisms underlying this property have not been fully elucidated. Here, we sought to I) analyze the effects of anti-CD44 mAbs on downstream signaling pathways, including the ERK1/2 (extracellular signal-regulated kinase 1 and 2) and mTOR (mammalian target of rapamycin) pathways and II) use state-of-the-art Nuclear Magnetic Resonance (NMR) technology to determine the global metabolic changes during differentiation induction of AML cells using anti-CD44 mAbs and other two previously reported differentiation agents. In the first objective (Chapter 4), our studies provide evidence that CD44-ligation with specific mAbs in AML cells induced an increase in ERK1/2 phosphorylation. The use of the MEK inhibitor (U0126) significantly inhibited the CD44-induced differentiation of HL60 cells, suggesting that ERK1/2 is critical for the CD44-triggered differentiation in AML. In addition, this was accompanied by a marked decrease in the phosphorylation of the mTORC1 and mTORC2 complexes, which are strongly correlated with the inhibition of the PI3K/Akt pathway. In the second objective (Chapter 5), 1H NMR experiments demonstrated that considerable changes in the metabolic profiles of HL60 cells were induced in response to each differentiation agent. These most notable metabolites that significantly changed upon CD44 ligation were involved in the tricarboxylic acid (TCA) cycle and glycolysis such as, succinate, fumarate and lactate. Therefore, we sought to analyze the mechanisms underlying their alterations. Our results revealed that anti-CD44 mAbs treatment induced upregulation in fumarate hydratase (FH) expression and its activity which was accompanied by a

Abnormal proliferation of CD4- CD8+ gammadelta+ T cells with chromosome 6 anomaly: role of Fas ligand expression in spontaneous regression of the cells.

Science.gov (United States)

Ichikawa, N; Kitano, K; Ito, T; Nakazawa, T; Shimodaira, S; Ishida, F; Kiyosawa, K

1999-04-01

We report a case of granular lymphocyte proliferative disorder accompanied with hemolytic anemia and neutropenia. Phenotypes of the cells were T cell receptor gammadelta+ CD3+ CD4- CD8+ CD16+ CD56- CD57-. Southern blot analysis of T cell receptor beta and gamma chains demonstrated rearranged bands in both. Chromosomal analysis after IL-2 stimulation showed deletion of chromosome 6. Sorted gammadelta+ T cells showed an increase in Fas ligand expression compared with the levels in sorted alphabeta+ T cells. The expression of Fas ligand on these gammadelta+ T cells increased after IL-2 stimulation. The patient's anemia improved along with a decrease in granular lymphocyte count and disappearance of the abnormal karyotype without treatment. The expression of Fas ligand may be involved in spontaneous regression of granular lymphocyte proliferation with hemolytic anemia.

Accompanied consultations in occupational health.

Science.gov (United States)

Hobson, J; Hobson, H; Sharp, R

2016-04-01

Accompanied consultations are often reported as difficult by occupational physicians but have not been studied in the occupational health setting. To collect information about accompanied consultations and the impact of the companion on the consultation. We collected data on all accompanied consultations by two occupational physicians working in a private sector occupational health service over the course of 16 months. Accompanied consultations were matched to non-accompanied consultations for comparison. We collected data on 108 accompanied consultations. Accompanied consultations were more likely to be connected with ill health retirement (P Occupational health practitioners may benefit from better understanding of accompanied consultations and guidance on their management. © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Geology and resource assessment of Costa Rica at 1:500,000 scale; a digital representation of maps of the U.S. Geological Survey's 1987 folio I-1865

Science.gov (United States)

Schruben, Paul G.

1997-01-01

This CD-ROM contains digital versions of the geology and resource assessment maps of Costa Rica originally published in USGS Folio I-1865 (U.S. Geological Survey, the Direccion General de Geologia, Minas e Hidrocarburos, and the Universidad de Costa Rica, 1987) at a scale of 1:500,000. The following layers are available on the CD-ROM: geology and faults; favorable domains for selected deposit types; Bouguer gravity data; isostatic gravity contours; mineral deposits, prospects, and occurrences; and rock geochemistry sample points. For DOS users, the CD-ROM contains MAPPER, a user-friendly map display program. Some of the maps are also provided in the following additional formats on the CD-ROM: (1) ArcView 1 and 3, (2) ARC/INFO 6.1.2 Export, (3) Digital Line Graph (DLG) Optional, and (4) Drawing Exchange File (DXF.)

Nodulation by Sinorhizobium meliloti originated from a mining soil alleviates Cd toxicity and increases Cd-phytoextraction in Medicago sativa L.

Science.gov (United States)

Ghnaya, Tahar; Mnassri, Majda; Ghabriche, Rim; Wali, Mariem; Poschenrieder, Charlotte; Lutts, Stanley; Abdelly, Chedly

2015-01-01

Besides their role in nitrogen supply to the host plants as a result of symbiotic N fixation, the association between legumes and Rhizobium could be useful for the rehabilitation of metal-contaminated soils by phytoextraction. A major limitation presents the metal-sensitivity of the bacterial strains. The aim of this work was to explore the usefulness of Sinorhizobium meliloti originated from a mining site for Cd phytoextraction by Medicago sativa. Inoculated and non-inoculated plants were cultivated for 60 d on soils containing 50 and/or 100 mg Cd kg(-1) soil. The inoculation hindered the occurrence of Cd- induced toxicity symptoms that appeared in the shoots of non-inoculated plants. This positive effect of S. meliloti colonization was accompanied by an increase in biomass production and improved nutrient acquisition comparatively to non-inoculated plants. Nodulation enhanced Cd absorption by the roots and Cd translocation to the shoots. The increase of plant biomass concomitantly with the increase of Cd shoot concentration in inoculated plants led to higher potential of Cd-phytoextraction in these plants. In the presence of 50 mg Cd kg(-1) in the soil, the amounts of Cd extracted in the shoots were 58 and 178 μg plant(-1) in non-inoculated and inoculated plants, respectively. This study demonstrates that this association M. sativa-S. meliloti may be an efficient biological system to extract Cd from contaminated soils.

A Community Terrain-Following Ocean Modeling System (ROMS)

Science.gov (United States)

2015-09-30

funded NOPP project titled: Toward the Development of a Coupled COAMPS-ROMS Ensemble Kalman filter and adjoint with a focus on the Indian Ocean and the...surface temperature and surface salinity daily averages for 31-Jan-2014. Similarly, Figure 3 shows the sea surface height averaged solution for 31-Jan... temperature (upper panel; Celsius) and surface salinity (lower panel) for 31-Jan-2014. The refined solution for the Hudson Canyon grid is overlaid on

Molecular Cloning, Expression and Characterization of Plasmid Encoding Rhomboid 4 (ROM4 of Tachyzoite of Toxoplasma gondii RH Strain

Directory of Open Access Journals (Sweden)

Mohammad Taghi RAHIMI

2017-12-01

Full Text Available AbstractBackground: The objective of this study was to clone, express and characterize the gene encoding rhomboid 4 (ROM4 proteins, a vital gene in surface adhesion and host cell invasion process of tachyzoite of T. gondii in an appropriate expression vector and eukaryotic cell for production of recombinant protein.Methods: Toxoplasma RNA was isolated from tachyzoites (RH strain and complementary DNA was synthesized. Oligonucleotide primer pair was designed based on Toxoplasma ROM4 gene sequence with XhoI and EcoRI restriction sites at 5´ end of forward and reverse primers, respectively. ROM4 gene was amplified by PCR, cloned into pTG19-T vector and the recombinant plasmid was sequenced. The gene was subcloned into pcDNA3 plasmid and expressed in CHO cells as eukaryotic cell. SDS-PAGE and western blotting were performed for protein determination and verification.Results: Cloning of ROM4 gene in pTG19-T vector was confirmed by colony-PCR and enzymatic digestion. The results of enzymatic digestion and gene sequencing confirmed successful cloning and subcloning procedures. The nucleotide sequence of the cloned ROM4 gene showed 99% homology compared to the corresponding sequences of original gene. SDS-PAGE and western blotting analyses of the purified protein revealed a single band having expected size of 65 kDa.Conclusion: This eukaryotic expression system is an appropriate system for high-level recombinant protein production of ROM4 gene from T. gondii tachyzoites used as antigenic component for serological assay and vaccine development.

Observing comets

CERN Document Server

James, Nick

2003-01-01

Since comet Shoemaker-Levy collided with the planet Jupiter with stupendous force in 1994 there has been an upsurge of amateur interest in comets Most comets are first discovered by amateur astronomers because there are so many amateurs looking for them, and techniques and instruments have improved dramatically in the past few years After a short but detailed introduction to the comets themselves Nick James and Gerald North describe comet hunting, photographing and imaging comets, and digital image processing The use of computers for orbital calculations and even helping to discover new comets is given a full chapter, as are advanced techniques including comet photometry and spectroscopy This comprehensive book has an accompanying CD-ROM and is at once a "primer" for comet hunters and a reference text for more advanced amateur astronomers

Infectious mononucleosis accompanied by clonal proliferation of EBV-infected cells and infection of CD8-positive cells.

Science.gov (United States)

Arai, Ayako; Yamaguchi, Takeshi; Komatsu, Honami; Imadome, Ken-Ichi; Kurata, Morito; Nagata, Kaoru; Miura, Osamu

2014-01-01

A 22-year-old male was admitted for a sustained fever of 2 months, lymphadenopathy, and liver dysfunction. Anti-VCA-IgM antibody was positive, with elevated Epstein-Barr virus (EBV)-DNA load in the peripheral blood. Liver biopsy revealed infiltration of CD8-positive and EBV-positive cells. Most peripheral blood mononuclear cells (PBMCs) were also positive for CD8, and showed detectable levels of EBV-DNA. Monoclonal proliferation of EBV-infected cells was detected in the PBMCs by Southern blotting for EBV-terminal repeat (EBV-TR). Although EBV-positive T-cell lymphoproliferative disease (EBV-T-LPD) was suspected, the symptoms spontaneously resolved within 12 months. Anti-VCA-IgM antibody and the clonal band of EBV-TR were negative 1 year after the onset, while anti-EBNA antibody was positive. The final diagnosis was thus confirmed as infectious mononucleosis (IM). Our results indicate that EBV-infected CD8-positive cells and clonal proliferation of EBV-infected cells may be temporally detected in IM. EBV-T-LPDs should be carefully excluded in such cases.

Naval Advanced Wood Composites- Project End Report (CD-ROM)

National Research Council Canada - National Science Library

Wolcott, Michael P

2004-01-01

.... Building durability problems can be traced to a range of factors that include moisture retention from impermeable building envelopes, moisture intrusion around doors and windows, and mechanical...

Songs of the Universe - The AstroCappella Project

Science.gov (United States)

Boyd, P. T.; Smale, K. M.; Smale, A. P.

2004-12-01

The AstroCappella Project is a classroom-ready collection of upbeat pop songs, lesson plans, and background information, all rich in science content. It was developed as a collaboration between working research astronomers, educators, and a contemporary vocal band. A multimedia music CD ("AstroCappella 2.0") has been produced containing 13 astronomically correct songs with original lyrics and music. Song topics range from the Sun, Moon, planets and small bodies of the Solar System, through the Doppler shift, the nearest stars, and extra-solar planets, to radio astronomy, X-ray astronomy, and the Hubble Space Telescope and Swift astronomy satellites. The CD also contains extensive CD-ROM materials including science background information, curriculum notes, lesson plans and activities for each song, images, movies, and slide shows. The songs and accompanying information have been extensively field-tested, and align to the K-12 National Science Education Standards. The AstroCappella materials are in widespread use in classrooms and homes across the US, and are supplemented with frequent live performances and teacher workshops. We describe here the history, content, and educational strategy behind the AstroCappella Project, and the plans for its future development.

Uudiseid ja meeldetuletusi raamatukogult / Karin Tulve

Index Scriptorium Estoniae

Tulve, Karin

2000-01-01

2000. aastast on TPÜ raamatukokku ostetud EBSCO online andmebaasid, augustist on võimalik kasutada referaat- ja täistekstandmebaasi Academic Search FullText International 15 CD-ROM-il ja septembrist humanitaarteaduste bibliograafilist andmebaasi Sophia : European Databases in the Humanities CD-ROM-il

NODC Standard Product: International ocean atlas Volume 11 - Climatic atlas of the Sea of Azov 2008 (1 disc set) (NODC Accession 0098574)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This Atlas, Climatic Atlas of the Sea of Azov 2008 on CD-ROM, is an update to Volume 10, Climatic Atlas of the Sea of Azov 2006 on CD-ROM (NODC Accession 0098572),...

Cooperativity of CD44 and CD49d in leukemia cell homing, migration, and survival offers a means for therapeutic attack.

Science.gov (United States)

Singh, Vibuthi; Erb, Ulrike; Zöller, Margot

2013-11-15

A CD44 blockade drives leukemic cells into differentiation and apoptosis by dislodging from the osteogenic niche. Because anti-CD49d also supports hematopoietic stem cell mobilization, we sought to determine the therapeutic efficacy of a joint CD49d/CD44 blockade. To unravel the underlying mechanism, the CD49d(-) EL4 lymphoma was transfected with CD49d or point-mutated CD49d, prohibiting phosphorylation and FAK binding; additionally, a CD44(-) Jurkat subline was transfected with murine CD44, CD44 with a point mutation in the ezrin binding site, or with cytoplasmic tail-truncated CD44. Parental and transfected EL4 and Jurkat cells were evaluated for adhesion, migration, and apoptosis susceptibility in vitro and in vivo. Ligand-binding and Ab-blocking studies revealed CD44-CD49d cooperation in vitro and in vivo in adhesion, migration, and apoptosis resistance. The cooperation depends on ligand-induced proximity such that both CD44 and CD49d get access to src, FAK, and paxillin and via lck to the MAPK pathway, with the latter also supporting antiapoptotic molecule liberation. Accordingly, synergisms were only seen in leukemia cells expressing wild-type CD44 and CD49d. Anti-CD44 together with anti-CD49d efficiently dislodged EL4-CD49d/Jurkat-CD44 in bone marrow and spleen. Dislodging was accompanied by increased apoptosis susceptibility that strengthened low-dose chemotherapy, the combined treatment most strongly interfering with metastatic settlement and being partly curative. Ab treatment also promoted NK and Ab-dependent cellular cytotoxicity activation, which affected leukemia cells independent of CD44/CD49d tail mutations. Thus, mostly owing to a blockade of joint signaling, anti-CD44 and anti-CD49d hamper leukemic cell settlement and break apoptosis resistance, which strongly supports low-dose chemotherapy.

34 CFR 600.2 - Definitions.

Science.gov (United States)

2010-07-01

... which the institution provides instructional materials, by mail or electronic transmission, including... communications devices; (3) Audio conferencing; or (4) Video cassettes, DVDs, and CD-ROMs, if the cassettes, DVDs...

Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.

LENUS (Irish Health Repository)

Donatello, Simona

2012-12-01

Cancer cell migration is an early event in metastasis, the main cause of breast cancer-related deaths. Cholesterol-enriched membrane domains called lipid rafts influence the function of many molecules, including the raft-associated protein CD44. We describe a novel mechanism whereby rafts regulate interactions between CD44 and its binding partner ezrin in migrating breast cancer cells. Specifically, in nonmigrating cells, CD44 and ezrin localized to different membranous compartments: CD44 predominantly in rafts, and ezrin in nonraft compartments. After the induction of migration (either nonspecific or CD44-driven), CD44 affiliation with lipid rafts was decreased. This was accompanied by increased coprecipitation of CD44 and active (threonine-phosphorylated) ezrin-radixin-moesin (ERM) proteins in nonraft compartments and increased colocalization of CD44 with the nonraft protein, transferrin receptor. Pharmacological raft disruption using methyl-β-cyclodextrin also increased CD44-ezrin coprecipitation and colocalization, further suggesting that CD44 interacts with ezrin outside rafts during migration. Conversely, promoting CD44 retention inside lipid rafts by pharmacological inhibition of depalmitoylation virtually abolished CD44-ezrin interactions. However, transient single or double knockdown of flotillin-1 or caveolin-1 was not sufficient to increase cell migration over a short time course, suggesting complex crosstalk mechanisms. We propose a new model for CD44-dependent breast cancer cell migration, where CD44 must relocalize outside lipid rafts to drive cell migration. This could have implications for rafts as pharmacological targets to down-regulate cancer cell migration.

Lipid Raft Association Restricts CD44-Ezrin Interaction and Promotion of Breast Cancer Cell Migration

Science.gov (United States)

Donatello, Simona; Babina, Irina S.; Hazelwood, Lee D.; Hill, Arnold D.K.; Nabi, Ivan R.; Hopkins, Ann M.

2012-01-01

Cancer cell migration is an early event in metastasis, the main cause of breast cancer-related deaths. Cholesterol-enriched membrane domains called lipid rafts influence the function of many molecules, including the raft-associated protein CD44. We describe a novel mechanism whereby rafts regulate interactions between CD44 and its binding partner ezrin in migrating breast cancer cells. Specifically, in nonmigrating cells, CD44 and ezrin localized to different membranous compartments: CD44 predominantly in rafts, and ezrin in nonraft compartments. After the induction of migration (either nonspecific or CD44-driven), CD44 affiliation with lipid rafts was decreased. This was accompanied by increased coprecipitation of CD44 and active (threonine-phosphorylated) ezrin-radixin-moesin (ERM) proteins in nonraft compartments and increased colocalization of CD44 with the nonraft protein, transferrin receptor. Pharmacological raft disruption using methyl-β-cyclodextrin also increased CD44-ezrin coprecipitation and colocalization, further suggesting that CD44 interacts with ezrin outside rafts during migration. Conversely, promoting CD44 retention inside lipid rafts by pharmacological inhibition of depalmitoylation virtually abolished CD44-ezrin interactions. However, transient single or double knockdown of flotillin-1 or caveolin-1 was not sufficient to increase cell migration over a short time course, suggesting complex crosstalk mechanisms. We propose a new model for CD44-dependent breast cancer cell migration, where CD44 must relocalize outside lipid rafts to drive cell migration. This could have implications for rafts as pharmacological targets to down-regulate cancer cell migration. PMID:23031255

Experimental study on gamma irradiation effects of floating gate ROMs The ROM is stated for Read-only Memory

CERN Document Server

He Chao Hui; Chen Xiao Hua; Wang Yan Ping; Peng Hong Lun

2002-01-01

Experimental results of gamma irradiation effects are given for Floating gate ROMs. There is an accumulated dose threshold. Errors occur when accumulated dose is above the threshold, no error occurs when below the threshold. The errors go up with the increase of the accumulated dose. Errors occur in devices that are measured during irradiation and irradiated in power on, moreover, new data cannot be written in these devices with programmer. However, under more accumulated dose, there is no error in devices in power off mode and new data can be written in these devices with programmer

Positron annihilation study on the Fermi surface of Cd-Mg alloys

International Nuclear Information System (INIS)

Koike, Shu-ichi; Hirabayashi, Makoto; Suzuki, Toshiharu; Hasegawa, Masayuki.

1979-01-01

Angular correlation measurements of annihilation photons have been made on single crystals of the Cd-Mg alloys over all compositions. It is found that the Fermi surfaces of the alloys in the Cd-rich region distort considerably from a free-electron sphere; the 3rd band ''stars'' and the 4th band horizontal ''cigars'' around the points L do not exist in Cd, and appear at 10 at % Mg accompanying an appreciable decrease of the energy gap at L. It is proposed that changes in the 4d core states cause the sudden decrease of the energy gap. (author)

75 FR 69693 - Privacy Act of 1974; Department of Homeland Security National Protection and Programs Directorate...

Science.gov (United States)

2010-11-15

... be shared with the Department); Citizenship; Contact information including phone numbers and email... magnetic disc, tape, digital media, and CD-ROM. Retrievability: Much of the data within this system does...

[Cost-effectiveness in Dutch mental health care: future because of ROM?

NARCIS (Netherlands)

Agthoven, M. van; Kolk, A. van der; Knegtering, H.; Delespaul, P.A.; Arends, J.; Jeurissen, P.P.T.; Krabbe, P.F.M.; Huijsman, R.; Luijk, R.; Beurs, E. de; Hakkaart-van Roijen, L.; Bruggeman, R.

2015-01-01

BACKGROUND: The document reporting Dutch mental health care negotiations for 2014 - 2017 calls for a cost decrease based on cost-effectiveness. Thanks to rom, the Dutch mental health care seems well prepared for cost-effectiveness research.
AIM: Evaluate how valid cost-effectiveness research

Multimedia Materials for Language and Literacy Learning.

Science.gov (United States)

Hallett, Terry L.

1999-01-01

Introduces educators to inexpensive, commercially-available CD-ROM software that combines speech, text, graphics, sound, video, animation, and special effects that may be incorporated into classroom activities for both normally developing and language learning disabled children. Discusses three types of multimedia CD-ROM products: (1) virtual…

Images of Kilauea East Rift Zone eruption, 1983-1993

Science.gov (United States)

Takahashi, Taeko Jane; Abston, C.C.; Heliker, C.C.

1995-01-01

This CD-ROM disc contains 475 scanned photographs from the U.S. Geological Survey Hawaii Observatory Library. The collection represents a comprehensive range of the best photographic images of volcanic phenomena for Kilauea's East Rift eruption, which continues as of September 1995. Captions of the images present information on location, geologic feature or process, and date. Short documentations of work by the USGS Hawaiian Volcano Observatory in geology, seismology, ground deformation, geophysics, and geochemistry are also included, along with selected references. The CD-ROM was produced in accordance with the ISO 9660 standard; however, it is intended for use only on DOS-based computer systems.

Ambient Temperature Based Thermal Aware Energy Efficient ROM Design on FPGA

DEFF Research Database (Denmark)

Saini, Rishita; Bansal, Neha; Bansal, Meenakshi

2015-01-01

Thermal aware design is currently gaining importance in VLSI research domain. In this work, we are going to design thermal aware energy efficient ROM on Virtex-5 FPGA. Ambient Temperature, airflow, and heat sink profile play a significant role in thermal aware hardware design life cycle. Ambient...

[Review of the CD Betel Nuts by Christopher Roberts (1996)

OpenAIRE

Senft, G.

2001-01-01

(TMCD 9602). Taipei: Trees Music & Art, 12-1, Lane 10, Sec. 2, Hsin Yi Rd. Taipei, TAIWAN. Distributed by Sony Music Entertainment (Taiwan)Ltd.,6th fl. No 35 , Lane 11, Kwang-Fu N. Rd., Taipei TAIWAN (CD accompanied by a full color bucklet)

An electrically reprogrammable 1024 bits MNOS ROM using MNOS-SOS e/d technology

International Nuclear Information System (INIS)

Mackowiak, E.; Le Goascoz, V.

1976-01-01

A 1024 bits fully decoded electrically writable and erasable non volatile ROM is described. Memory cells and peripheral circuits are made using P channel silicon on sapphire enhancement depletion technology [fr

Management of waste from French nuclear fuel cycle: what are the key issues?

International Nuclear Information System (INIS)

Londres, V.; Do Quang, R.; FOURNIER, P.

2001-01-01

The publication on 2 CD-ROMs and includes 145 presentations delivered at the congress. In the work of the International Youth Nuclear Congress 2000 participated 288 young scientific works from over 30 countries. The address discusses the following sessions: Young Generation Session Nuclear Education and Transfer of Know-How; Nuclear Technology I; Political Aspects; Nuclear Technology II; Environment and Safety; Communication and Public Perception I; Communication and Public Perception II; Nuclear Programs and Technical Cooperation; Economics; Fuel Cycle Challenges. Each paper has been indexed separately. Before of full papers the first CD contains next chapters: Introduction (in 19 languages); General Information; Day by Day; Y-Notes Session Results; Sponsors; Media Album, and Conclusions. The second CD-ROM contains 28 minutes of video-film about programme of International Youth Nuclear Congress 2000. (authors)

International Youth Nuclear Congress 2000: Youth, Future, Nuclear. Proceedings and Multimedia Presentation

International Nuclear Information System (INIS)

2001-01-01

The publication on CD-ROM and includes 145 presentations delivered at the congress. In the work of the International Youth Nuclear Congress 2000 participated 288 young scientific works from over 30 countries. The address discusses the following sessions: Young Generation Session Nuclear Education and Transfer of Know-How; Nuclear Technology I; Political Aspects; Nuclear Technology II; Environment and Safety; Communication and Public Perception I; Communication and Public Perception II; Nuclear Programs and Technical Cooperation; Economics; Fuel Cycle Challenges. Each paper has been indexed separately. Before of full papers the first CD contains next chapters: Introduction (in 19 languages); General Information; Day by Day; Y-Notes Session Results; Sponsors; Media Album, and Conclusions. The second CD-ROM contains 28 minutes of video-film about programme of International Youth Nuclear Congress 2000

HAEA NEPO tools used in nuclear emergency response

International Nuclear Information System (INIS)

Horvath, K.; Koblinger, L.

2001-01-01

The publication on 2 CD-ROMs and includes 145 presentations delivered at the congress. In the work of the International Youth Nuclear Congress 2000 participated 288 young scientific works from over 30 countries. The address discusses the following sessions: Young Generation Session Nuclear Education and Transfer of Know-How; Nuclear Technology I; Political Aspects; Nuclear Technology II; Environment and Safety; Communication and Public Perception I; Communication and Public Perception II; Nuclear Programs and Technical Cooperation; Economics; Fuel Cycle Challenges. Each paper has been indexed separately. Before of full papers the first CD contains next chapters: Introduction (in 19 languages); General Information; Day by Day; Y-Notes Session Results; Sponsors; Media Album, and Conclusions. The second CD-ROM contains 28 minutes of video-film about programme of International Youth Nuclear Congress 2000. (authors)

Pesticide Information Sources in the United States.

Science.gov (United States)

Alston, Patricia Gayle

1992-01-01

Presents an overview of electronic and published sources on pesticides. Includes sources such as databases, CD-ROMs, books, journals, brochures, pamphlets, fact sheets, hotlines, courses, electronic mail, and electronic bulletin boards. (MCO)

Cd induced redistribution of elements within leaves of the Cd/Zn hyperaccumulator Thlaspi praecox as revealed by micro-PIXE

International Nuclear Information System (INIS)

Pongrac, Paula; Vogel-Mikus, Katarina; Vavpetic, Primoz; Tratnik, Janja; Regvar, Marjana; Simcic, Jurij; Grlj, Natasa; Pelicon, Primoz

2010-01-01

A detailed localisation of elements within leaf tissues of hydroponically grown Cd/Zn hyperaccumulator Thlaspi praecox (Brassicaceae) was determined by micro-PIXE at Jozef Stefan Institute (Ljubljana, Slovenia) in order to study accumulation patterns of Cd and other elements in the case of a single metal (Cd) pollution. Plants were treated with increasing concentrations of Cd in the solution (0 (control), 1, 10 and 100 μM). As expected, concentration of Cd in the leaves gradually increased with Cd concentration in the solution. In order to reveal the main Cd storage compartment space within the leaves a relative element distribution (pool) was calculated based on concentrations of elements in specific leaf tissues and their weight portions. Where present at detectable levels, Cd accumulated in the epidermal tissues (at 10 μM), but the contribution of epidermal pool decreased with increasing Cd concentration in solution (at 100 μM). The opposite was observed for the mesophyll pool. In addition, in Cd treated plants, a significant decrease in mesophyll Fe pool and an increase in the epidermal Fe pool were observed. Similar effect was seen for Mn pool at 100 μM Cd treatment accompanied by increasing Zn epidermal pool with increasing Cd in nutrient solution. Altogether these results indicate repartitioning of essential mesophyll cation pools (e.g., Fe, Mn and possibly Zn) when increasing Cd contents, that are instead more intensively stored in the epidermal cells. These results confirmed micro-PIXE as effective and powerful technique providing essential information on metal localisation, repartitioning and major elemental stores in plants on the tissue levels that were not accessible using classical analytical techniques and thus complementing our current understanding of plant metal tolerance mechanisms as a whole.

"Coaching the Camp Coach: Leadership Development for Small Organizations" Resource Review

Directory of Open Access Journals (Sweden)

Jason Hedrick

2009-09-01

Full Text Available Coaching is an important component of successful professional growth for leaders within any organization. However, organizations with limited resources may have challenges providing such coaching opportunities. This can be especially true for small business, non profit organizations and summer camps. “Coaching the Camp Coach; Leadership Development for Small Organizations” by Shelton, M. (2003 provides a framework, both in theory and practice, for camp leaders to improve interpersonal and intrapersonal skills through self evaluation. Accompanying the book is a CD-ROM that has multiple worksheets to be used in conjunction with the text.

Biomes.

Science.gov (United States)

Web Feet K-8, 2001

2001-01-01

This annotated subject guide to Web sites and additional resources focuses on biomes. Specifies age levels for resources that include Web sites, CD-ROMs and software, videos, books, audios, and magazines; includes professional resources; and presents a relevant class activity. (LRW)

CD4(+)/CD8(+) T-lymphocyte Ratio: Effects of Rehydration before Exercise in Dehydrated Men

Science.gov (United States)

Greenleaf, John E.; Jackson, Catherine G. R.; Lawless, Desales

1995-01-01

Effects of fluid ingestion on CD4+/CD8+ T-lymphocyte cell ratios were measured in four dehydrated men (ages 30-46 yr) before and after 70 min of supine submaximal (71 % VO(sub 2max) lower extremity cycle exercise. Just before exercise, Evans blue dye was injected for measurement of plasma volume. The subjects then drank one of six fluid formulations (12 ml/kg) in 3-4 min. All six mean post-hydration (pre-exercise) CD4+/CD8+ ratios (Becton-Dickinson Fluorescence Activated Cell Sorter and FACScan Consort-30 software program were below the normal range of 1.2-1.5; mean (+/- SE) and range were 0.77 +/- 0.12 and 0.39-1.15, respectively. The post-exercise ratios increased: mean = 1.36 =/- 0.15 (P less than 0.05) and range = 0.98-1.98. Regression of mean CD4+/CD8+ ratios on mean plasma osmolality resulted in pre- and post-exercise correlation coefficients of -0.76 (P less than 0.10) and -0.92 (P less than 0.01), respectively. The decreased pre-exercise ratios (after drinking) were probably not caused by the Evans blue dye but appeared to be associated more with the stress (osmotic) of dehydration. The increased post-exercise ratios to normal levels accompanied the rehydration and were not due to the varied electrolyte and osmotic concentrations of the ingested fluids or to the varied vascular volume shifts during exercise. Thus, the level of subject hydration and plasma osmotality may be factors involved in the mechanism of immune system modulation induced by exercise.

The effects of neural mobilization on cervical radiculopathy patients' pain, disability, ROM, and deep flexor endurance.

Science.gov (United States)

Kim, Dong-Gyu; Chung, Sin Ho; Jung, Ho Bal

2017-09-22

Cervical radiculopathy (CR) is a disease of the cervical spine and a space-occupying lesion that occurs because of pathological problems with cervical nerve roots. Nerve root injury to produce functional disability. The purpose of this study was to examine the effects of neural mobilization with manual cervical traction (NMCT) compared with manual cervical traction (MCT) on pain, functional disability, muscle endurance, and range of motion (ROM) in individuals with CR patients. A blinded randomized clinical trial was conducted. Thirty CR patients were divided into two groups - those who received NMCT and those who received MCT. The intervention was applied three times per week for eight weeks. It was measured in order to determine the pain and functional disability in patients with CR. The numeric pain rating scale (NPRS), neck disability index (NDI), ROM, and deep flexor endurance of patients were measured prior to the experiment, four weeks, and eight weeks after the experiment to compare the time points. A repeated-measures analysis of variance was used to compare differences within each group prior to the experiment. And Bonferroni test was performed to examine the significance of each time point. There were significant differences within each group prior to the intervention, four weeks after the intervention, and eight weeks after the intervention in NPRS, NDI, ROM, and deep flexor endurance (Ppain relief, recovery from neck disability, ROM, and deep flexor endurance for patients with CR.

Excel for chemists: a comprehensive guide

National Research Council Canada - National Science Library

Billo, E. Joseph

2011-01-01

..., biological, and medicinal calculations. Including a CD-ROM for Windows, this new edition provides chemists and students with the a detailed guide to using the current versions of Excel (Excel 2007 and 2010...

NODC Standard Product: Global ocean temperature and salinity profiles (2 disc set) (NODC Accession 0098058)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This set of CD-ROMs contains global ocean temperature and salinity profiles derived from NODC archive data files. It includes oceanographic station (bottle) data,...

NODC Standard Product: Gulf of Mexico hydrographic data and marine mammal data (NODC Accession 0095924)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This CD-ROM was produced in cooperation with the Texas A&M University (TAMU), Department of Oceanography. It includes hydrographic and marine mammal sighting...

Purchasing an Encyclopedia: 12 Points To Consider. Fifth Edition.

Science.gov (United States)

American Library Association, Chicago, IL.

This book discusses issues to consider when purchasing an encyclopedia and provides reviews of eight print encyclopedias, six CD-ROM encyclopedias, and one online encyclopedia. Each review provides an address and discusses the history, scope and treatment, and quality and currency of the encyclopedia; for CD-ROM encyclopedias, the database…

Fusion energy 2002. 19th conference proceedings

International Nuclear Information System (INIS)

2003-01-01

This CD-ROM contains the proceedings of the 19th International Conference on Fusion energy 2002, held in Lyon, France, on 14-19 October 2002. The CD-Rom contains HTML files for navigation via WEB brouser, the papers in PDF and Acrobat Reader 5 for Windows, Mac-OS and UNIX

Myosin 1g Contributes to CD44 Adhesion Protein and Lipid Rafts Recycling and Controls CD44 Capping and Cell Migration in B Lymphocytes

Directory of Open Access Journals (Sweden)

Orestes López-Ortega

2017-12-01

Full Text Available Cell migration and adhesion are critical for immune system function and involve many proteins, which must be continuously transported and recycled in the cell. Recycling of adhesion molecules requires the participation of several proteins, including actin, tubulin, and GTPases, and of membrane components such as sphingolipids and cholesterol. However, roles of actin motor proteins in adhesion molecule recycling are poorly understood. In this study, we identified myosin 1g as one of the important motor proteins that drives recycling of the adhesion protein CD44 in B lymphocytes. We demonstrate that the lack of Myo1g decreases the cell-surface levels of CD44 and of the lipid raft surrogate GM1. In cells depleted of Myo1g, the recycling of CD44 was delayed, the delay seems to be caused at the level of formation of recycling complex and entry into recycling endosomes. Moreover, a defective lipid raft recycling in Myo1g-deficient cells had an impact both on the capping of CD44 and on cell migration. Both processes required the transportation of lipid rafts to the cell surface to deliver signaling components. Furthermore, the extramembrane was essential for cell expansion and remodeling of the plasma membrane topology. Therefore, Myo1g is important during the recycling of lipid rafts to the membrane and to the accompanied proteins that regulate plasma membrane plasticity. Thus, Myosin 1g contributes to cell adhesion and cell migration through CD44 recycling in B lymphocytes.

Adolescencia, relaciones románticas y actividad sexual: una revisión

Directory of Open Access Journals (Sweden)

Elvia Vargas

2002-01-01

Full Text Available Se presenta una revisión de algunas de las investigaciones más recientes sobre la adolescencia y los factores asociados a las relaciones románticas y la actividad sexual durante la adolescencia. Se parte de la premisa de que el análisis de la iniciación romántica y sexual durante la adolescencia requiere de modelos de causalidad múltiple que permitan dar cuenta, conjuntamente, de los factores que se encuentran en los contextos individual, familiar y social asociados con estos dos procesos. Se destaca el papel de los padres en el desarrollo de hijos adolescentes autónomos, capaces de manejar la influencia negativa del grupo de pares. Se hacen algunas recomendaciones a los responsables de diseñar programas de prevención y a los interesados en el estudio de la adolescencia y en el desarrollo de la disciplina

Poemele homerice în veșminte românești. O analiză diacronică (I

Directory of Open Access Journals (Sweden)

Petre Gheorghe Bârlea

2015-07-01

Full Text Available Lucrarea pe care o propunem vizează istoria traducerilor românești ale poemelor homerice, din perspectiva evoluției limbii române literare. Pornim de la premisa că orice asemenea traducere reprezintă o probă de virtuozitate nu numai pentru traducătorul în cauză, ci și pentru limba și cultura modernă respectivă, așa încît este interesant de studiat modul în care dezvoltarea exegezei homerice și a teoriilor traductologice se manifestă în paralel cu etapele evoluției limbilor moderne. Grila de analiză va include, așadar, principii, metode și instrumente de lucru ale domeniilor amintite aici (istoria limbii, traductologie, dar și elemente împrumutate din gramatica constrastiv-tipologică, din filologie, în sensul restrîns al conceptului, din teoria mentalităților, istoria culturală ș.a. Demersul nostru evidențiază faptul că evoluția istorică a actului traducerii este marcată, în mod firesc, de personalitatea traducătorului (opțiuni teoretice, ideologice, pe lîngă competențe lingvistice, har poetic etc., dar și de contextul cultural al epocii și al spațiului respectiv. Pentru cultura română, cel puțin, putem constata că, în ansamblu, versiunea cea mai recentă este și cea mai reușită.

Pigmentary glaucoma accompanied by Usher syndrome.

Science.gov (United States)

Koucheki, Behrooz; Jalali, Kamran Hodjat

2012-08-01

To report a case of pigmentary glaucoma (PG) accompanied by Usher syndrome. Case report. The results were presented after standard ocular examination, visual field test, anterior segment and fundus photography, electroretinography, and otolaryngology consultation were conducted. Typical retinitis pigmentosa, flat electroretinography, congenital sensorineural hearing loss, high intraocular pressure, Krukenberg spindle, iris concavity, radial iris transillumination defect, severe pigment deposition on the trabecular meshwork, and glaucomatous optic nerve damage were indicative of PG accompanied by Usher syndrome. In some rare cases, PG may coexist with Usher syndrome. Common findings of Usher syndrome, including night blindness, impaired vision, visual field defects, and retinal changes may distract the clinician from considering the diagnosis of glaucoma. Such association should be borne in mind to make a timely diagnosis and treatment possible.

Looking Up: Multimedia about Space and Flight.

Science.gov (United States)

Walter, Virginia A.

1998-01-01

The best CD-ROMs for young people about space and flight exploit the promise of hypermedia to create informative simulations. This article provides an annotated bibliography of CD-ROMs on astronomy and flight for K-12 students; suggests book and Internet connections; and highlights poetry for astronomers, science fiction, a biography of Charles…

Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

DEFF Research Database (Denmark)

Bache, Michael; Bosco, Filippo; Brøgger, Anna Line

2013-01-01

In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels...

Introduction to suspended-sediment sampling

Science.gov (United States)

Nolan, K. Michael; Gray, John R.; Glysson, G. Douglas

2005-01-01

Knowledge of the amount and timing of sediment transport in streams is important to those directly or indirectly responsible for developing and managing water and land resources. Such data are often used to judge the health of watershed and the success or failure of activities designed to mitigate adverse impacts of sediment on streams and stream habitats. This training class presents an introduction to methods currently used by the U.S. Geological Survey (USGS) to sample suspended-sediment concentrations in streams. The presentation is narrated, but you control the pace of the presentation. If the computer you are using can view 'MPEG' videos you will be able to take advantage of videos interspersed in the presentation. A test, found at the end of the presentation, can be taken to assess how well you understood the training material. The class, which is registered as class SW4416 with the National Training Center of the USGS, should take two or three hours to complete. In order to use the presentation provided via this Web page, you will need to download a large disc images (linked below) and 'burn' it to a blank CD-ROM using a CD-ROM recorder on your computer. The presentation will only run on a Windows-based personal computer (PC). The presentation was developed using Macromedia Director MX 20041 and is contained in the file 'SIR05-5077.exe' which should autolaunch. If it does not, the presentation can be started by double-clicking on the file name. A sound card and speakers are necessary to take advantage of narrations that accompany the presentation. Text of narrations is provided, if you are unable to listen to narrations. Instructions for installing and running the presentation are included in the file 'Tutorial.htm', which is on the CD. 1 Registered Trademark: Macromedia Incorporated

Pitfalls in the Assessment, Analysis, and Interpretation of Routine Outcome Monitoring (ROM) Data : Results from an Outpatient Clinic for Integrative Mental Health

NARCIS (Netherlands)

Hoenders, Rogier H. J.; Bos, Elisabeth H.; Bartels-Velthuis, Agna A.; Vollbehr, Nina K.; van der Ploeg, Karen; de Jonge, Peter; de Jong, Joop T. V. M.

There is considerable debate about routine outcome monitoring (ROM) for scientific or benchmarking purposes. We discuss pitfalls associated with the assessment, analysis, and interpretation of ROM data, using data of 376 patients. 206 patients (55 %) completed one or more follow-up measurements.

Provocarea Facebook pentru bibliotecile publice din România

Directory of Open Access Journals (Sweden)

Octavia-Luciana Madge

2014-01-01

Full Text Available Reţelele sociale şi-au câştigat rapid un loc în viaţa noastră şi în activitatea multor organizaţii şi instituţii publice şi private. La nivelul bibliotecilor, reţelele sociale şi-au demonstrat utilitatea şi rolul în calitate de instrumente de marketing pentru o mai bună comunicare cu utilizatorii. Bibliotecile publice din România au cunoscut în ultimul timp transformări mari în ceea ce priveşte modul de abordare a relaţiei cu utilizatorii şi îmbunătăţirea activităţii lor. Au lansat, de asemenea, o serie de noi servicii pentru a răspunde nevoilor comunităţii pe care o servesc şi pentru a atrage noi utilizatori. Implementarea şi utilizarea de noi aplicaţii precum reţelele de socializare online, mai exact Facebook, a fost una dintre aceste dezvoltări recente. Această lucrare analizează modul în care reţelele sociale sunt utilizate la nivelul bibliotecilor publice din România prin exemplul a trei biblioteci publice mari şi a modului în care aceste biblioteci îşi promovează serviciile prin intermediul reţelei Facebook.

Personal Hearing Protection including Active Noise Reduction (Les dispositifs de protection de l'ouie, y compris l'attenuation du bruit actif) (CD-ROM)

National Research Council Canada - National Science Library

Steeneken, H. J; Dancer, A; McKinley, R; Buck, K; James, S

2005-01-01

.... SYSTEMS DETAIL NOTE: Adobe Acrobat Reader is included on disc. ABSTRACT: Personal hearing protection and speech communication facilities are essential for optimal performance in military operations...

Video demystified

CERN Document Server

Jack, Keith

2004-01-01

This international bestseller and essential reference is the "bible" for digital video engineers and programmers worldwide. This is by far the most informative analog and digital video reference available, includes the hottest new trends and cutting-edge developments in the field. Video Demystified, Fourth Edition is a "one stop" reference guide for the various digital video technologies. The fourth edition is completely updated with all new chapters on MPEG-4, H.264, SDTV/HDTV, ATSC/DVB, and Streaming Video (Video over DSL, Ethernet, etc.), as well as discussions of the latest standards throughout. The accompanying CD-ROM is updated to include a unique set of video test files in the newest formats. *This essential reference is the "bible" for digital video engineers and programmers worldwide *Contains all new chapters on MPEG-4, H.264, SDTV/HDTV, ATSC/DVB, and Streaming Video *Completely revised with all the latest and most up-to-date industry standards.

Old PCs: Upgrade or Abandon?

Science.gov (United States)

Perez, Ernest

1997-01-01

Examines the practical realities of upgrading Intel personal computers in libraries, considering budgets and technical personnel availability. Highlights include adding RAM; putting in faster processor chips, including clock multipliers; new hard disks; CD-ROM speed; motherboards and interface cards; cost limits and economic factors; and…

MoKS teistes koostööprojektides / John Grzinich

Index Scriptorium Estoniae

Grzinich, John

2005-01-01

13. III Genfis toimunud helikunstiüritusest "VernalFLUX / Kevadvool", millest Eestist võtsid osa MoKS'i koordinaatorid John Grzinich ja Evelyn Müürsepp, nende performance'ist "Maaheli. Unustatud unistused". Uuest organisatsioonist Claudmirror, mis on välja andnud seitse CD-ROM-i, nende seas John Grzinichi CD-ROM-i "Võrdsed ja kauged jooned"

75 FR 9380 - Cooperative Conservation Partners Initiative; Wetlands Reserve Enhancement Program

Science.gov (United States)

2010-03-02

... paper) of the written proposal and one electronic copy on CD-ROM in MS WORD or PDF. If submitting more... proposal and one electronic copy on CD-ROM in MS WORD or PDF. If submitting more than one project proposal... Mexico. Stretching 2,350 miles from its headwaters at Lake Itasca, Minnesota, to the mouth of the Gulf of...

Artificial Intelligence-Explosive Ordnance Disposal Information Search, Retrieval, and Delivery System

Science.gov (United States)

1992-04-01

megabytes greater than required to store the operating system and X-Windows. * CD-ROM Player. Standard CD-ROM player using ISO 9660 file format...CAVGERRO 235 .4596 . 8583 .0000 4.0000 42 CAVGFOUN 235 3.9362 .3700 .0000 4.0000 43 SlIT 235 172.3106 207.4205 .0000 1039.0000 44 S2T 235 122.0638

Characterization of primary cutaneous CD8+/CD30+ lymphoproliferative disorders.

Science.gov (United States)

Martires, Kathryn J; Ra, Seong; Abdulla, Farah; Cassarino, David S

2015-11-01

CD30 primary cutaneous lymphoproliferative diseases include both lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (PCALCL). The neoplastic cell of most primary CD30 lymphoproliferative disorders is CD4 positive. The terminology LyP "type D" has been used to describe a growing number of cases of LyP with a predominantly CD8 infiltrate. PCALCL with a CD8 phenotype has also been described, which presents a particularly difficult diagnostic and management challenge, given the difficulty in distinguishing it histologically from other cytotoxic lymphomas such as primary cutaneous aggressive epidermotropic CD8 cytotoxic T-cell lymphoma and CD8 gamma/delta and natural killer/T-cell lymphoma. We report 7 additional cases of these rare cutaneous CD8/CD30 lymphoproliferative disorders. We also present a unique case of CD8/CD30 LyP with histologic similarities to LyP type B. In all 7 of our cases of CD8 LyP and CD8 anaplastic large cell lymphoma, we found focal to diffuse MUM-1 positivity. We propose that MUM-1 may represent an adjunctive marker for CD8 lymphoproliferative disease. Finally, we review the current literature on cases of CD8 LyP and PCALCL. For the 106 cases examined, we found similar clinical and histologic features to those reported for traditional CD4CD30 LyP and PCALCL.

Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

Directory of Open Access Journals (Sweden)

Manda V Sasidhar

Full Text Available CD147 is an activation induced glycoprotein that promotes the secretion and activation of matrix metalloproteinases (MMPs and is upregulated during the differentiation of macrophages. Interestingly, some of the molecular functions of CD147 rely on its glycosylation status: the highly glycosylated forms of CD147 induce MMPs whereas the lowly glycosylated forms inhibit MMP activation. Statins are hydroxy-methylglutaryl coenzyme A reductase inhibitors that block the synthesis of mevalonate, thereby inhibiting all mevalonate-dependent pathways, including isoprenylation, N-glycosylation and cholesterol synthesis. In this study, we investigated the role of statins in the inhibition of macrophage differentiation and the associated process of MMP secretion through modulation of CD147. We observed that differentiation of the human monocytic cell line THP-1 to a macrophage phenotype led to upregulation of CD147 and CD14 and that this effect was inhibited by statins. At the molecular level, statins altered CD147 expression, structure and function by inhibiting isoprenylation and N-glycosylation. In addition, statins induced a shift of CD147 from its highly glycosylated form to its lowly glycosylated form. This shift in N-glycosylation status was accompanied by a decrease in the production and functional activity of MMP-2 and MMP-9. In conclusion, these findings describe a novel molecular mechanism of immune regulation by statins, making them interesting candidates for autoimmune disease therapy.

Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

Science.gov (United States)

Sasidhar, Manda V; Chevooru, Sai Krishnaveni; Eickelberg, Oliver; Hartung, Hans-Peter; Neuhaus, Oliver

2017-01-01

CD147 is an activation induced glycoprotein that promotes the secretion and activation of matrix metalloproteinases (MMPs) and is upregulated during the differentiation of macrophages. Interestingly, some of the molecular functions of CD147 rely on its glycosylation status: the highly glycosylated forms of CD147 induce MMPs whereas the lowly glycosylated forms inhibit MMP activation. Statins are hydroxy-methylglutaryl coenzyme A reductase inhibitors that block the synthesis of mevalonate, thereby inhibiting all mevalonate-dependent pathways, including isoprenylation, N-glycosylation and cholesterol synthesis. In this study, we investigated the role of statins in the inhibition of macrophage differentiation and the associated process of MMP secretion through modulation of CD147. We observed that differentiation of the human monocytic cell line THP-1 to a macrophage phenotype led to upregulation of CD147 and CD14 and that this effect was inhibited by statins. At the molecular level, statins altered CD147 expression, structure and function by inhibiting isoprenylation and N-glycosylation. In addition, statins induced a shift of CD147 from its highly glycosylated form to its lowly glycosylated form. This shift in N-glycosylation status was accompanied by a decrease in the production and functional activity of MMP-2 and MMP-9. In conclusion, these findings describe a novel molecular mechanism of immune regulation by statins, making them interesting candidates for autoimmune disease therapy.

9 CFR 93.208 - Articles accompanying poultry.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Articles accompanying poultry. 93.208... AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY PRODUCTS; REQUIREMENTS...

Şcoli şi biserici româneşti din Peninsula Balcanică 1864-1948. Documente de arhivă

Directory of Open Access Journals (Sweden)

Adina Berciu-Drăghicescu

2006-01-01

Full Text Available Articolul de faţă privind şcolile şi bisericile româneşti din Peninsula Balcanică în perioada 1918-1948 este realizat pe baza unor documente identificate în fonduri păstrate la Arhivele Diplomatice ale Ministerului Afacerilor Externe şi la Direcţia Arhivelor Naţioanle Istorice Centrale din Bucureşti. Au fost studiate şi selectate documente de cea mai mare semnificaţie în scopul prezentării evoluţiei situaţiei şcolilor şi bisericilor comunităţilor româneşti situate la sud de Dunăre începând cu anul 1864, când a fost înfiinţată prima şcoală în Târnova (Macedonia şi până în 1948 când statul român a abandonat acţiunea iniţiată de conducătorul Al. Ioan Cuza. Articolul prezintă această situaţie, foarte dramatică, a comunităţilor româneşti din Balcani pe baza documentelor de arhivă.

Biomes and Natural Cycles. [CD-ROM].

Science.gov (United States)

1996

This interactive multimedia software illustrates and explains life on planet Earth through colorful and dynamic representations. Clear explanations and animation elucidate a variety of subjects such as the organization of the ecosphere, the flux of energy, water cycles, climates, and characteristics of regions across the globe. Five animated films…

Non-stoichiometry and properties of SnTe left angle Cd right angle semiconducting phase of variable composition

International Nuclear Information System (INIS)

Rogacheva, E.I.; Nashchekina, O.N.

2006-01-01

It was established that the dependences of microhardness, hole concentration, electrical conductivity, and the Seebeck coefficient on composition in the Sn 0.984 Te-Cd and Sn 0.984 Te-CdTe solid solutions based on non-stoichiometric tin telluride exhibit non-monotonic behavior. The effects connected with the interaction between intrinsic and impurity defects and with critical phenomena accompanying a transition to the impurity continuum were isolated. The results obtained in this work represent another evidence for our proposition about the universal character of critical phenomena accompanying the transition from an impurity discontinuum to an impurity continuum in solid solutions. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (Abstract Copyright [2006], Wiley Periodicals, Inc.)

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells

OpenAIRE

Wang, Xiaomei; Su, Jin; Sherman, Alexandra; Rogers, Geoffrey L.; Liao, Gongxian; Hoffman, Brad E.; Leong, Kam W.; Terhorst, Cox; Daniell, Henry; Herzog, Roland W.

2015-01-01

Coadministering FIX orally and systemically induces tolerance via complex immune regulation, involving tolerogenic dendritic and T-cell subsets.Induced CD4+CD25−LAP+ regulatory T cells with increased IL-10 and TGF-β expression and CD4+CD25+ regulatory T cells suppress antibody formation against FIX.

Virtual instruments in practice. Proceedings of the VIP 2001 Congress

International Nuclear Information System (INIS)

Jamal, R.; Jaschinski, H.

2001-01-01

The book presents and discusses important new software developments in all fields of metrology. There are competent and clear contributions on the many aspects and applications of computer-aided laboratory measurement, general test bench applications, automotive metrology, intranet and internet metrology, vision and motion, general medical technology, and image processing in medical technology. The focus is on image processing, which has seen rapid development during the past few years, but practical applications in other fields on the basis of LabView or National Instruments products are not neglected. The text is illustrated by pictures and tables and is accompanied by a CD-ROM with a demo version of Measurement Studio [de

Applied medical image processing a basic course

CERN Document Server

Birkfellner, Wolfgang

2014-01-01

A widely used, classroom-tested text, Applied Medical Image Processing: A Basic Course delivers an ideal introduction to image processing in medicine, emphasizing the clinical relevance and special requirements of the field. Avoiding excessive mathematical formalisms, the book presents key principles by implementing algorithms from scratch and using simple MATLAB®/Octave scripts with image data and illustrations on an accompanying CD-ROM or companion website. Organized as a complete textbook, it provides an overview of the physics of medical image processing and discusses image formats and data storage, intensity transforms, filtering of images and applications of the Fourier transform, three-dimensional spatial transforms, volume rendering, image registration, and tomographic reconstruction.

Proceedings of the distribution automation seminar. CD-ROM ed.

International Nuclear Information System (INIS)

2003-01-01

Electric utilities are being driven to improve the utilization of their distribution system assets while reducing life cycle costs. This seminar provided an opportunity for electric utilities to share their experience and knowledge about the constantly evolving technologies that apply to distributed automation. Customers and their representatives place increased priority on regulatory commissions to achieve reliability and push the conventional use of distribution automation into rural areas. Various options are under consideration by managers to incorporate a variety of distributed generation resources. Several papers highlighted technical aspects as they relate to applications to meet the changing needs of utilities. The latest products and technologies in the field were on display. The seminar sessions included: business cases; utility experience and applications; utility experience and projects; and, technology and equipment. Eight presentations were indexed separately for inclusion in this database

Fas (CD95) expression and death-mediating function are induced by CD4 cross-linking on CD4+ T cells.

OpenAIRE

Desbarats, J; Freed, J H; Campbell, P A; Newell, M K

1996-01-01

The CD4 receptor contributes to T-cell activation by coligating major histocompatibility complex class II on antigen presenting cells with the T-cell receptor (TCR)/CD3 complex, and triggering a cascade of signaling events including tyrosine phosphorylation of intracellular proteins. Paradoxically, CD3 cross-linking prior to TCR stimulation results in apoptotic cell death, as does injection of anti-CD4 antibodies in vivo of CD4 ligation by HIV glycoprotein (gp) 120. In this report we investig...

Foliar application with nano-silicon alleviates Cd toxicity in rice seedlings.

Science.gov (United States)

Wang, Shihua; Wang, Fayuan; Gao, Shuangcheng

2015-02-01

Nanofertilizers may be more effective than regular fertilizers in improving plant nutrition, enhancing nutrition use efficiency, and protecting plants from environmental stress. A hydroponic pot experiment was conducted to study the role of foliar application with 2.5 mM nano-silicon in alleviating Cd stress in rice seedlings (Oryza sativa L. cv Youyou 128) grown in solution added with or without 20 μM CdCl2. The results showed that Cd treatment decreased the growth and the contents of Mg, Fe, Zn, chlorophyll a, and glutathione (GSH), accompanied by a significant increase in Cd accumulation. However, foliar application with nano-Si improved the growth, Mg, Fe, and Zn nutrition, and the contents of chlorophyll a of the rice seedlings under Cd stress and decreased Cd accumulation and translocation of Cd from root to shoot. Cd treatment produced oxidative stress to rice seedlings indicated by a higher lipid peroxidation level (as malondialdehyde (MDA)) and higher activities of antioxidant enzymes such as superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), and a lower GSH content. However, those nano-Si-treated plants had lower MDA but higher GSH content and different antioxidant enzyme activities, indicating a higher Cd tolerance in them. The results suggested that nano-Si application alleviated Cd toxicity in rice by decreasing Cd accumulation, Cd partitioning in shoot and MDA level and by increasing content of some mineral elements (Mg, Fe, and Zn) and antioxidant capacity.

19 CFR 148.4 - Accompanying articles.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Accompanying articles. 148.4 Section 148.4 Customs... (CONTINUED) PERSONAL DECLARATIONS AND EXEMPTIONS General Provisions § 148.4 Accompanying articles. (a) Generally. Articles shall be considered as accompanying a passenger or brought in by him if the articles...

Information Technology and the Third Industrial Revolution.

Science.gov (United States)

Fitzsimmons, Joe

1994-01-01

Discusses the so-called third industrial revolution, or the information revolution. Topics addressed include the progression of the revolution in the U.S. economy, in Europe, and in Third World countries; the empowering technologies, including digital switches, optical fiber, semiconductors, CD-ROM, networks, and combining technologies; and future…

European cement conference and exhibition. Proceedings volume

Energy Technology Data Exchange (ETDEWEB)

McCaffrey, R. (ed.)

2004-07-01

Topics covered various aspects of the European cement industry including trends, market, emissions trading, environment, state-of-the-art technology, kilns and dedusting solutions. Two papers have been abstracted separately. A CD-ROM of the conference papers, including additional papers not in the printed volume, is also available.

Galvenais varonis Dž.K.Roulingas romānu sērijā "Harijs Poters"

OpenAIRE

Kalsone, Ineta

2012-01-01

Dotā bakalaura darba temats ir "Galvenais varonis Dž.K. Roulingas romānu sērijā "Harijs Poters". Pirmajā nodaļā es analizēju sērijas popularitāti, publicēšanas datus un apbalvojumus, ko saņēmusi Dž.K. Roulinga. Otrajā nodaļā tiek analizēti dažādi raksturojuma veidi. Sīkāk tiek pētīta galvenā varoņa un citu nozīmīgāko tēlu loma. Meklējuma literatūras elementi,kas dod pamatu galvenā varoņa izaugsmei, tika analizēti detalizēti. Trešajā nodaļā tiek analizēta galvenā varoņa izaugsme šajā romānu sē...

Novel teleost CD4-bearing cell populations provide insights into the evolutionary origins and primordial roles of CD4+ lymphocytes and CD4+ macrophages

OpenAIRE

Takizawa, Fumio; Magadan, Susana; Parra, David; Xu, Zhen; Koryt����, Tom����; Boudinot, Pierre; Sunyer, J. Oriol

2016-01-01

Tetrapods contain a single CD4 co-receptor with four immunoglobulin domains that likely arose from a primordial two-domain ancestor. Notably, teleost fish contain two CD4 genes. Like tetrapod CD4, CD4-1 of rainbow trout includes four immunoglobulin domains while CD4-2 contains only two. Since CD4-2 is reminiscent of the prototypic two-domain CD4 co-receptor, we hypothesized that by characterizing the cell types bearing CD4-1 and CD4-2, we would shed light into the evolution and primordial rol...

Fine mapping of Best`s macular dystrophy localises the gene in close proximity to, but distinct from, the D115480/ROM1

Energy Technology Data Exchange (ETDEWEB)

Graff, C.; Ahlbom, B.E.; Anneren, G. [University Hospital, Uppsala (Sweden)] [and others

1994-09-01

Best`s macular dystrophy (BMD) is an autosomal dominant disease characterized by accumulation of lipofuscin beneath the pigment epithelium of the macula, leading to early-onset impairment of central vision. The gene has previously been mapped to 11q13. Based on DNA from 191 people from a large 12-generation family, the gene now has been mapped to a 1.5 cM interval between the markers Fc{epsilon}RI and D11S480/ROM1. By disequilibrium analysis the gene was estimated to be 0.321 cM centromeric to the marker D11S480. Since this on average corresponds to 300 kb, the gene may be at a distance contained in YAC molecules. To physically characterize this region, YAC clones positive for markers flanking BMD have been identified. Sequence analysis of the candidate gene ROM1 did not reveal any mutation. However, one recombination between intragenic ROM1 polymorphisms and BMD was detected, which make it highly unlikely that mutations in ROM1 are causing BMD.

Cisplatin Induces Up-Regulation of KAI1, a Metastasis Suppressor ...

African Journals Online (AJOL)

HP

including breast, testicular, ovarian, cervical, prostate, head and neck, ..... Vertebral bone metastasis in breast cancer: a case report. Rom J Morphol Embryol 2011; 52: 897-. 905. ... KAI1/CD82 on the β1 integrin maturation in highly migratory ...

"Tuberculosis Case Management" Training.

Science.gov (United States)

Knebel, Elisa; Kolodner, Jennifer

2001-01-01

The need to isolated health providers with critical knowledge in tuberculosis (TB) case management prompted the development of "Tuberculosis Case Management" CD-ROM. Features include "Learning Center,""Examination Room," and "Library." The combination of audio, video, and graphics allows participants to…

Electronic Publishing: Baseline Data 1993.

Science.gov (United States)

Brock, Laurie

1993-01-01

Provides highlights of a report describing research conducted to analyze and compare publishers' and developers' current and planned involvement in electronic publishing. Topics include acceptance of new media, licensing issues, costs and other perceived obstacles, and CD-ROMs platforms. (EAM)

Papers of the remediation technologies symposium 2005. CD-ROM ed.

International Nuclear Information System (INIS)

2005-01-01

This conference was attended by over 500 delegates and provided an opportunity for industry, practitioners, researchers and regulators to discuss technical issues in environmental remediation research and recent innovations in soil and groundwater remediation. Sessions included presentations on in-situ, groundwater and surface water remediation. Issues concerning phytoremediation, natural attenuation, extraction and commercial redevelopment were examined. The aim of the conference was also to provide a forum for innovators in remediation to present new work. Topics included hydrocarbon and salt contamination; engineered soil cover for management of salt impacted sites; remediation and revegetation of tar sands composite tailings containing naphthenic acids; sorption of oil sands naphthenic acid mixtures; denitrification as a natural attenuation mechanism; sampling methodologies; variability assessments; stabilization treatment technologies; remediation of coal wastes; bioreactor landfills; well blowouts in Alberta; soil remediation in coarse gravelly soils; diesel-contaminated aquifers; gasoline spill remediation; soil vapour extraction systems; technological solutions for erosion control and water clarification; and cost-effective in-situ remediation strategies. Fifty-two technical presentations were given, of which 27 have been catalogued separately for inclusion in this database

Papers of the remediation technologies symposium 2005. CD-ROM ed.

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-07-01

This conference was attended by over 500 delegates and provided an opportunity for industry, practitioners, researchers and regulators to discuss technical issues in environmental remediation research and recent innovations in soil and groundwater remediation. Sessions included presentations on in-situ, groundwater and surface water remediation. Issues concerning phytoremediation, natural attenuation, extraction and commercial redevelopment were examined. The aim of the conference was also to provide a forum for innovators in remediation to present new work. Topics included hydrocarbon and salt contamination; engineered soil cover for management of salt impacted sites; remediation and revegetation of tar sands composite tailings containing naphthenic acids; sorption of oil sands naphthenic acid mixtures; denitrification as a natural attenuation mechanism; sampling methodologies; variability assessments; stabilization treatment technologies; remediation of coal wastes; bioreactor landfills; well blowouts in Alberta; soil remediation in coarse gravelly soils; diesel-contaminated aquifers; gasoline spill remediation; soil vapour extraction systems; technological solutions for erosion control and water clarification; and cost-effective in-situ remediation strategies. Fifty-two technical presentations were given, of which 27 have been catalogued separately for inclusion in this database. tabs., figs.

Validation of the computer code system ATHLET / ATHLET-CD. Final report; Validierung des Rechenprogrammsystems ATHLET / ATHLET-CD. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Austregesilo, H.; Bals, C.; Erdmann, W.; Horche, W.; Krzykacz-Hausmann, B.; Pointner, W.; Schoeffel, P.; Skorek, T.; Weber, S.; Wielenberg, A.

2010-04-15

In the frame of the reactor safety project RS1173, sponsored by the German Federal Ministry of Economics and Technology, analyses of international integral and separate effects tests have been performed for the validation of the code system ATHLET/ATHLET-CD. The work mainly comprised post-test calculations of selected experiments and the contributions to the working groups accompanying the experimental programs. For the assessment of the thermal-hydraulic models in ATHLET 8 integral tests and 4 separate effect tests have been considered. Together with the corroboration of the existing models, the validation analyses were mainly dedicated to the assessment of the modelling of non-condensable gases and their influence on two-phase natural circulation and on the primary heat removal through steam generators, as well as of the simulation of multi-dimensional flow processes. The validation calculations with respect to the simulation of multi-dimensional one- and two-phase flows aimed to investigate the range of applicability and limitations of the method of parallel channels in connection with the separate momentum equations for water and steam current used in ATHLET as well as to assess the status of the coupled version ATHLET/FLUBOX-3D. The ATHLET-CD validation analyses included the post-test calculations of 9 bundle tests, and was mainly focussed on the assessment of the improved and new models for core degradation, including the models for oxidation, melt formation and relocation for BWR components, as well as of the modelling of fission products and aerosol transport within the primary circuit taking into account chemical reactions within the module SOPHAEROS. As an additional contribution to code validation, the GRS methodology of uncertainty and sensitivity analysis was applied exemplarily to two validation calculations, one with ATHLET and one with ATHLET-CD. The results of these uncertainty analyses endorse the capability of the code system to reproduce

COPPER RESISTANT STRAIN CANDIDA TROPICALIS RomCu5 INTERACTION WITH SOLUBLE AND INSOLUBLE COPPER COMPOUNDS

Directory of Open Access Journals (Sweden)

Ie. P. Prekrasna

2015-10-01

Full Text Available The focus of the study was interaction of Candida tropicalis RomCu5 isolated from highland Ecuador ecosystem with soluble and insoluble copper compounds. Strain C. tropicalis RomCu5 was cultured in a liquid medium of Hiss in the presence of soluble (copper citrate and CuCl2 and insoluble (CuO and CuCO3 copper compounds. The biomass growth was determined by change in optical density of culture liquid, composition of the gas phase was measured on gas chromatograph, redox potential and pH of the culture fluid was defined potentiometrically. The concentration of soluble copper compounds was determined colorimetrically. Maximal permissible concentration of Cu2+ for C. tropicalis RomCu5 was 30 000 ppm of Cu2+ in form of copper citrate and 500 ppm of Cu2+ in form of CuCl2. C. tropicalis was metabolically active at super high concentrations of Cu2+, despite the inhibitory effect of Cu2+. C. tropicalis immobilized Cu2+ in the form of copper citrate and CuCl2 by it accumulation in the biomass. Due to medium acidification C. tropicalis dissolved CuO and CuCO3. High resistance of C. tropicalis to Cu2+ and ability to interact with soluble and insoluble copper compounds makes it biotechnologically perspective.

Spectrophotometry (by Barbara Sawrey and Gabriele Wienhausen)

Science.gov (United States)

Pringle, David L.

1998-08-01

Science Media: San Diego, 1997. 1-10 copies, 99 each; 11-20 copies, 69 each; 21+ copies, $49 each. (Note: CD operates with both Mac and PC.) Spectrophotometry is an interactive CD-ROM which introduces the basics of UV-visible spectrophotometry with some mention of infrared and other forms of spectrophotometry. A Macintosh System 7.5 or higher, CPU 68040 or Power PC processor, 6 megabytes of free RAM, 2.6 megabytes of free disk space, and 4X CD-ROM or faster are required.

Mergers and acquisitions: valuation and risk assessment; CD-ROM ed.

Energy Technology Data Exchange (ETDEWEB)

McVeigh, C.A. [Currie Coopers and Lybrand, Toronto, ON (Canada)

1996-04-01

An overview of various aspects of mergers and acquisition transactions in the petroleum industry were presented. Incentives to mergers and acquisitions were reviewed and discussed, among them value opportunity, critical size, incremental tax pools, financial distress, shareholder dissatisfaction, strategic infrastructure position, complementary assets, and undeveloped land inventory. Current trends in mergers and acquisitions were highlighted. An industry checklist for risk assessments discussing financial position, engineering forecasts, and taxation was also included.

Executive Summaries: CIL '90.

Science.gov (United States)

Elsweiler, John A., Jr.; And Others

1990-01-01

Presents summaries of 12 papers presented at the 1990 Computers in Libraries Conference. Topics discussed include online searching; microcomputer-based serials management; microcomputer-based workstations; online public access catalogs (OPACs); multitype library networking; CD-ROM searches; locally mounted online databases; collection evaluation;…

2008 Availability and Utilization of Electronic Information Databases ...

African Journals Online (AJOL)

Gbaje E.S

electronic information databases include; research work, to update knowledge in their field of interest and Current awareness. ... be read by a computer device. CD ROMs are ... business and government innovation. Its ... technologies, ideas and management practices ..... sources of information and storage devices bring.

What's in Your Techno-Future? Vendors Share Their Views.

Science.gov (United States)

Gerber, Carole

1995-01-01

Examines vendors' views on the future of CD-ROM technology. Topics include the library role, single point access, costs, tape backup, user-friendly library automation systems and databases, improved quality, the growth of Internet access, and perspectives on technology in schools. (AEF)

Mythology.

Science.gov (United States)

Web Feet K-8, 2001

2001-01-01

This annotated subject guide to Web sites and additional resources focuses on mythology. Specific age levels are given for resources that include Web sites, CD-ROMs and software, videos, books, audios, and magazines; offers professional resources; and presents a relevant class activity. (LRW)

Surface preparation effects on efficient indium-tin-oxide-CdTe and CdS-CdTe heterojunction solar cells

Science.gov (United States)

Werthen, J. G.; Fahrenbruch, A. L.; Bube, R. H.; Zesch, J. C.

1983-05-01

The effects of CdTe surface preparation and subsequent junction formation have been investigated through characterization of ITO/CdTe and CdS/CdTe heterojunction solar cells formed by electron beam evaporation of indium-tin-oxide (ITO) and CdS onto single crystal p-type CdTe. Surfaces investigated include air-cleaved (110) surfaces, bromine-in-methanol etched (110) and (111) surfaces, and teh latter surfaces subjected to a hydrogen heat treatment. Both air-cleaved and hydrogen heat treated surfaces have a stoichiometric Cd to Te ratio. The ITO/CdTe junction formation process involves an air heat treatment, which ahs serious effects on the behavior of junctions formed on these surfaces. Etched surfaces which have a large excesss of Te, are less affected by the junction formation process and result in ITO/CdTe heterojunctions with solar efficiencies of 9% (Vsc =20 mA/cm2). Use of low-doped CdTe results in junctions characterized by considerably larger open-circuit votages (Voc =0.81 V) which are attributable to increasing diode factors caused by a shift from interfacial recombination to recombination in the depletion region. Resulting solar efficiencies reach 10.5% which is the highest value reported to date for a genuine CdTe heterojunction, CdS/CdTe heterojunctions show a strong dependence on CdTe surface condition, but less influence on the junction formation process. Solar efficiencies of 7.5% on an etched and heat treated surface are observed. All of these ITO/CdTe and CdS/CdTe heterojunctions have been stable for at least 10 months.

Dāvida Lodža „Mazā pasaule” un „Paradīzes jaunumi” kā piedzīvojumu romāni

OpenAIRE

Kaušakīte, Inessa

2007-01-01

Maģistra darbā „Deivida Lodža „Mazā pasaule” un „Paradīzes Jaunumi” kā piedzīvojumu romāni” mērķis ir pievērst uzmanību piedzīvojuma žanra dažādām īpatnībām mūsdienu angļu romānista darbos. Darbs arī atklāj postmodernā piedzīvojumu romāna varoņa rakstura īpatnības. Pirmā nodaļa izceļ klasiskā 16. gadsimta spāņu literatūras piedzīvojumu romāna svarīgākās īpatnības. Šī nodaļa pēta apstākļus, kas palīdzējuši žanra attīstībai Anglijā. Otrā nodaļa pievērš uzmanību Deivida Lodža liktenim, kas kā...

Training project on Radiological Protection in medicine. Use of new technologies

International Nuclear Information System (INIS)

Ruis-Cruces, R.; Perez-Martinez, M.; Pastor Vega, J. M.; Diez de los Rios Delgado, A.

2003-01-01

Radiological protection training addressed to physicians should start during the teaching graduate and postgraduate studies, and a third phase only for those physicians using X rays and radioactive sources in diagnosis and treatment of diseases. To show a training project addressed to the teaching graduate students based on the new technologies, such as web online and interactive CD-ROM. Development of a web-online including information in.pdf (adobe acrobat) format and additional tools (as data bases, videos, news and class meetings, FAQ, tutorials). Moreover, we propose to development an interactive CD-ROM which will be used as a practical tool to complete the obligatory subject on radiological protection in the University of Malaga (Spain). We show the preliminary phase of the project. The web-online is being developed with the Microsoft FrontPage software. The first version of the CR-ROM is being developed in html format. These tools based on new technologies will be a very important support for radiological protection training, which is recommended by International Organizations (EC Report R116 and IAE Action Plan 2002-2006). (Author) 4 refs

CD sundials

Science.gov (United States)

Bokor, Nándor

2018-01-01

In this paper I present various equatorial sundial designs that use diffraction on a CD to display time. The designs described in the paper include a transparent CD sundial equipped with a small terrestrial globe. This sundial is compact, pedagogically useful, can be used throughout the year, and provides the user with a wealth of information.

Increased Aqueous Humor CD4+/CD8+ Lymphocyte Ratio in Sarcoid Uveitis.

Science.gov (United States)

Dave, Namita; Chevour, Priyanka; Mahendradas, Padmamalini; Venkatesh, Anitha; Kawali, Ankush; Shetty, Rohit; Ghosh, Arkasubhra; Sethu, Swaminathan

2018-02-08

To determine aqueous humor CD4+/CD8+ T-lymphocyte ratio changes in sarcoid and non-sarcoid uveitis with anterior chamber involvement. The case-control study includes 61 patients with either anterior uveitis, intermediate uveitis with anterior spill, or panuveitis. A total of 21 of them were categorized as sarcoid uveitis and 40 as non-sarcoid uveitis according to diagnostic criteria. CD4+/CD8+ ratio in the aqueous humor was determined using flow cytometry. Significantly higher CD4+/CD8+ ratio in the aqueous humor was observed in patients with sarcoid uveitis (6.3 ± 1.4; mean ± SEM) compared to non-sarcoid uveitis (1.6 ± 0.1; mean ± SEM). Whole blood CD4+/CD8+ ratio was not elevated in subjects with sarcoid and non-sarcoid uveitis. Aqueous humor CD4+/CD8+ ratio >3.5 was observed to be associated with sarcoid uveitis (OR 38, 95% CI 7.0-205.2). Increased aqueous humor CD4+/CD8+ ratio in sarcoid uveitis. Immunophenotyping of localized lymphocytosis in aqueous humor could be utilized as an additional confirmatory marker for ocular sarcoidosis.

LOYALTY – THE NUCLEUS OF BRAND CAPITAL. CASE STUDY: ROM CHOCOLATE BAR

Directory of Open Access Journals (Sweden)

Brindusa Mariana Amalancei

2013-12-01

Full Text Available It is considered that loyalty to the brand of some primary customers is the core of the brand capital. A brand, however, may have substantial value, which is given to it by its symbol and slogans, if it is continued with the purchase of a brand after the buyers have made a comparison with the competing products that have superior characteristics. Structured on several levels, which are each a different marketing challenge, the loyalty to the brand consists of many factors, among which the most important is the user experience. The paper aims to highlight, starting from a series of articles in online media, the manner in which a traditional Romanian brand, ROM chocolate bar, continuously repositions itself, attempting to maintain and even increase the loyalty of its consumers, as well as to answer the consumer’s authenticity, accessibility, credibility and modernity needs. Even though in specialized literature there are opinions according to which traditional brands are commonly old-fashioned or dull, ROM chocolate bar shows the opposite view, being considered a successful brand which is appreciated both at national and international levels.

Using multimedia to link experts' views and derive common conclusions

DEFF Research Database (Denmark)

Howard, Rob

1997-01-01

Introductory paper to an issue of Automation in Construction edited by the author with papers from several contributors to the Building IT 2005 multimedia CD-ROM on the future of IT in the construction industry......Introductory paper to an issue of Automation in Construction edited by the author with papers from several contributors to the Building IT 2005 multimedia CD-ROM on the future of IT in the construction industry...

Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection

DEFF Research Database (Denmark)

Goldeck, David; Larsen, Lisbeth Aagaard; Christiansen, Lene

2016-01-01

from the Danish Twin Registry for their T-cell differentiation status, assessed by surface expression of CD27, CD28, CD57, and KLRG-1. We observed a significant intraclass correlation between cotwins of MZ, but not DZ pairs for the differentiation status of CD4(+) and CD8(+) subsets. Classical......A latent infection with cytomegalovirus (CMV), a ubiquitous beta herpesvirus, is associated with an accumulation of late-differentiated memory T-cells, often accompanied by a reciprocal reduced frequency of early-differentiated cells (commonly also referred to as "naïve"). However, this impact...... of CMV on T-cell phenotypes is variable between individuals. Our previous findings in a subgroup of participants in the Leiden familial Longevity Study indicated an important role of genetics. For further testing, we have analyzed middle-aged monozygotic (MZ, n = 42) and dizygotic (DZ, n = 39) twin pairs...

Static aeroelastic analysis including geometric nonlinearities based on reduced order model

Directory of Open Access Journals (Sweden)

Changchuan Xie

2017-04-01

Full Text Available This paper describes a method proposed for modeling large deflection of aircraft in nonlinear aeroelastic analysis by developing reduced order model (ROM. The method is applied for solving the static aeroelastic and static aeroelastic trim problems of flexible aircraft containing geometric nonlinearities; meanwhile, the non-planar effects of aerodynamics and follower force effect have been considered. ROMs are computational inexpensive mathematical representations compared to traditional nonlinear finite element method (FEM especially in aeroelastic solutions. The approach for structure modeling presented here is on the basis of combined modal/finite element (MFE method that characterizes the stiffness nonlinearities and we apply that structure modeling method as ROM to aeroelastic analysis. Moreover, the non-planar aerodynamic force is computed by the non-planar vortex lattice method (VLM. Structure and aerodynamics can be coupled with the surface spline method. The results show that both of the static aeroelastic analysis and trim analysis of aircraft based on structure ROM can achieve a good agreement compared to analysis based on the FEM and experimental result.

Intercomparison of Antarctic ice-shelf, ocean, and sea-ice interactions simulated by MetROMS-iceshelf and FESOM 1.4

Science.gov (United States)

Naughten, Kaitlin A.; Meissner, Katrin J.; Galton-Fenzi, Benjamin K.; England, Matthew H.; Timmermann, Ralph; Hellmer, Hartmut H.; Hattermann, Tore; Debernard, Jens B.

2018-04-01

An increasing number of Southern Ocean models now include Antarctic ice-shelf cavities, and simulate thermodynamics at the ice-shelf/ocean interface. This adds another level of complexity to Southern Ocean simulations, as ice shelves interact directly with the ocean and indirectly with sea ice. Here, we present the first model intercomparison and evaluation of present-day ocean/sea-ice/ice-shelf interactions, as simulated by two models: a circumpolar Antarctic configuration of MetROMS (ROMS: Regional Ocean Modelling System coupled to CICE: Community Ice CodE) and the global model FESOM (Finite Element Sea-ice Ocean Model), where the latter is run at two different levels of horizontal resolution. From a circumpolar Antarctic perspective, we compare and evaluate simulated ice-shelf basal melting and sub-ice-shelf circulation, as well as sea-ice properties and Southern Ocean water mass characteristics as they influence the sub-ice-shelf processes. Despite their differing numerical methods, the two models produce broadly similar results and share similar biases in many cases. Both models reproduce many key features of observations but struggle to reproduce others, such as the high melt rates observed in the small warm-cavity ice shelves of the Amundsen and Bellingshausen seas. Several differences in model design show a particular influence on the simulations. For example, FESOM's greater topographic smoothing can alter the geometry of some ice-shelf cavities enough to affect their melt rates; this improves at higher resolution, since less smoothing is required. In the interior Southern Ocean, the vertical coordinate system affects the degree of water mass erosion due to spurious diapycnal mixing, with MetROMS' terrain-following coordinate leading to more erosion than FESOM's z coordinate. Finally, increased horizontal resolution in FESOM leads to higher basal melt rates for small ice shelves, through a combination of stronger circulation and small-scale intrusions of

CD133 expression in osteosarcoma and derivation of CD133⁺ cells.

Science.gov (United States)

Li, Ji; Zhong, Xiao-Yan; Li, Zong-Yu; Cai, Jin-Fang; Zou, Lin; Li, Jian-Min; Yang, Tao; Liu, Wei

2013-02-01

Cluster of differentiation 133 (CD133) is recognized as a stem cell marker for normal and cancerous tissues. Using cell culture and real‑time fluorescent polymerase chain reaction, CD133 expression was analyzed in osteosarcoma tissue and Saos‑2 cell lines. In addition, cancer stem cell‑related gene expression in the Saos‑2 cell line was determined to explore the mechanisms underlying tumorigenesis and high drug resistance in osteosarcoma. CD133+ cells were found to be widely distributed in various types of osteosarcoma tissue. Following cell culture, cells entered the G2/M and S cell cycle stages from G0/G1. Levels of CD133+ cells decreased to normal levels rapidly over the course of cell culture. Colony forming efficiency was higher in the CD133+ compared with the CD133‑ subpopulation of Saos‑2 cells. Expression levels of stem cell‑related genes, including multidrug resistance protein 1 (MDR1) and sex determining region Y‑box 2 (Sox2) in the CD133+ subpopulation of cells were found to be significantly higher compared with the CD133‑ subpopulation. These observations indicate that CD133+ Saos‑2 cells exhibit stem cell characteristics, including low abundance, quiescence and a high potential to undergo differentiation, as well as expression of key stem cell regulatory and drug resistance genes, which may cause osteosarcoma and high drug resistance.

Thinking Like a Government Documents Librarian.

Science.gov (United States)

Malone, Chuck

1998-01-01

Explains ways to find government information on the Internet and from other sources such as online catalogs and CD-ROMs. Highlights include determining the appropriate agency involved, sources of information, finding statistics, researching legislation, the relationship between laws and regulations, and ambiguous citations. (LRW)

Searching U.S. Patents: Core Collection and Suggestions for Service.

Science.gov (United States)

Harwell, Kevin R.

1993-01-01

Provides fundamental information about patents, describes effective and affordable reference resources, and discusses specific issues in providing patent information services to inventors and other patrons. Basic resources, including CD-ROM products, patent classification and searching resources, and other search tools are described in an…

A Comparison of Pricing Strategies for Bibliographical Databases on CDROM and Equivalent Printed Products.

Science.gov (United States)

Rowley, Jennifer; Butcher, David

1994-01-01

Considers comparative prices for bibliographic data on CD-ROM and in print. Topics addressed include differences in the nature of bibliographic data in the two media, the relative complexities of pricing structure, varying policies on network pricing, and standardization of the licensing arrangement. (KRN)

Media Magic: Automating a K-12 Library Program in a Rural District.

Science.gov (United States)

Adams, Helen

1994-01-01

Describes the automation process in a library resources center in a small rural school district. Topics discussed include long-range planning; retrospective conversion for an online catalog; library automation software vendors; finances; training; time savings; CD-ROM products; telecomputing; computer literacy skills; professional development…

SEM REGRA NEM FREIOS - Loucura e criação na discussão romântica em torno do gênio

Directory of Open Access Journals (Sweden)

Yuri Cerqueira dos Anjos

2014-12-01

Full Text Available A relação entre genialidade e loucura, tópos bastante antigo, parece ganhar contornos peculiares no pensamento romântico. Inspirado, ultrassensível, isolado e visionário, o gênio romântico transita com certa frequência no campo semântico da loucura. Entre oráculo, profeta e louco, ele se caracteriza pela sua capacidade de transgredir o estado atual das coisas e criar um novo mundo de possibilidades e experiências. Nesse sentido, exploraremos no presente artigo alguns aspectos dessa relação entre o gênio e o louco no contexto do debate romântico francês do início do século XIX e no livro William Shakespeare, de Victor Hugo.

White random lasing in mixture of ZnSe, CdS and CdSSe micropowders

Science.gov (United States)

Alyamani, A. Y.; Leanenia, M. S.; Alanazi, L. M.; Aljohani, M. M.; Aljariwi, A. A.; Rzheutski, M. V.; Lutsenko, E. V.; Yablonskii, G. P.

2016-03-01

Room temperature random lasing with white light emission in a mixture of AIIBVI semiconductor powders was achieved for the first time. The scattering gain media was formed by the mixture of closely packed active micron sized crystallites of ZnSe, CdS, CdSSe semiconductors. The micropowders were produced by grinding bulk crystals of each compound. Optical excitation was performed by 10-nanosecond pulses of tuned Ti:Al2O3-laser at 390 nm. The lasing in the mixture of semiconductor powders was achieved simultaneously at four wavelengths in blue, green, yellow and red spectral regions after exceeding the threshold excitation power density. A drastic integral intensity increase, spectrum narrowing and appearance of mode structure accompanied the laser action. ZnSe crystallites produce the laser light at about 460 nm while CdS particles - at about 520 nm. Two types of CdSSe semiconductor micropowders with different sulfur content lase at 580 nm and 660 nm. The threshold excitation power densities for all laser lines in the emission spectrum are approximately the same of about 0.9 MW/cm2. The sum of the emission spectrum of the mixture of the micropowders forms white light with high brightness. Lasing is due to an appearance of random feedback for amplified radiation in the active medium of closely packed light scattering crystallites. The presented results may find their applications for visualization systems, lighting technology, data transmission, medicine as biosensors and in identification systems. The key feature of random lasers is low cost of its production and possibility to be deposited on any type of surface.

Perspective on One Decade of Laser Propulsion Research at the Air Force Research Laboratory, November 1995-2005 (DVD)

National Research Council Canada - National Science Library

2007-01-01

.... PHYSICAL DESCRIPTION: 1 DVD-ROM and 1 CD-ROM; 4 3/4 in.; 395 MB. ABSTRACT: A short film and presentation on laser propulsion research at the Air Force Research Laboratory, spanning November 1995 through October 2005...

Surgical management of complete penile duplication accompanied by multiple anomalies.

Science.gov (United States)

Karaca, Irfan; Turk, Erdal; Ucan, A Basak; Yayla, Derya; Itirli, Gulcin; Ercal, Derya

2014-09-01

Diphallus (penile duplication) is very rare and seen once every 5.5 million births. It can be isolated, but is usually accompanied by other congenital anomalies. Previous studies have reported many concurrent anomalies, such as bladder extrophy, cloacal extrophy, duplicated bladder, scrotal abnormalities, hypospadias, separated symphysis pubis, intestinal anomalies and imperforate anus; no penile duplication case accompanied by omphalocele has been reported. We present the surgical management of a patient with multiple anomalies, including complete penile duplication, hypo-gastric omphalocele and extrophic rectal duplication.

Abordagens do amor romântico: aspectos históricos, sociais e literários

Directory of Open Access Journals (Sweden)

Luana Grasiela Schonarth

2015-06-01

Full Text Available O presente estudo vincula-se ao projeto de pesquisa Narrativas e conhecimentos: especificidades teóricas e constituição de sentido, coordenado pela Prof.ª Dra. Eunice Terezinha Piazza Gai. Considerando os caminhos cursados no desenvolvimento da pesquisa, utilizamos o tema do amor para refletir sobre os possíveis conhecimentos que o processo narrativo propicia, os aspectos históricos e sociais nos quais a temática foi abordada na literatura, assim como um resgate de informações acerca das origens do tema e personagens consolidados nos romances românticos. Nessa perspectiva, delimitamos o estudo entre os amores irrealizados, os impasses responsáveis pelos impedimentos amorosos, bem como os conflitos entre a paixão e o casamento nas narrativas românticas. Para bem fundamentar esta pesquisa, tomamos o mito considerado matriz das histórias de amor, o próprio nascimento da paixão na literatura ocidental: Tristão e Isolda. O mito apresenta a visão do amor cortês e as contradições que se manifestaram desde a segunda metade do século XII entre a regra cavalheiresca e os costumes feudais. Diante da teoria do amor, abstraída do mito do amor romântico, partimos para a literatura do século XIX, considerando a presença dos amores não correspondidos. Nesta etapa, analisamos o romance de Balzac, Eugênia Grandet, que se torna exemplo da irrealização amorosa na literatura, vivida de modo mais contundente pela personagem que intitula a obra. A escolha dessa narrativa, para a análise do amor-paixão, deve-se ao fato de que o casamento é tratado como mero interesse financeiro, desconsiderando todo e qualquer envolvimento amoroso entre o casal em questão: Eugênia e Charles. Tratamos, pois, desta pluralidade significativa, deste amplo caminho trilhado não só pela literatura, mas por todos aqueles que se deixam despertar pela eternidade e fascínio dos romances românticos.

Immune regulation by CD40-CD40-l interactions - 2; Y2K update.

Science.gov (United States)

van Kooten, C

2000-11-01

CD40 is a cell surface receptor, which belongs to the TNF-R family, and which was first identified and functionally characterized on B lymphocytes. However, in recent years it has become clear that CD40 is expressed much broader, including expression on monocytes, dendritic cells, endothelial cells and epithelial cells. Therefore it is now thought that CD40 plays a more general role in immune regulation. The present paper reviews recent developments in this field of research, with main emphasis on CD40 signal transduction and on in vivo functions of CD40/CD40-L interactions.

ADP ribosyl-cyclases (CD38/CD157), social skills and friendship.

Science.gov (United States)

Chong, Anne; Malavasi, Fabio; Israel, Salomon; Khor, Chiea Chuen; Yap, Von Bing; Monakhov, Mikhail; Chew, Soo Hong; Lai, Poh San; Ebstein, Richard P

2017-04-01

Why some individuals seek social engagement while others shy away has profound implications for normal and pathological human behavior. Evidence suggests that oxytocin (OT), the paramount human social hormone, and CD38 that governs OT release, contribute to individual differences in social skills from intense social involvement to extreme avoidance that characterize autism. To explore the neurochemical underpinnings of sociality, CD38 expression of peripheral blood leukocytes (PBL) was measured in Han Chinese undergraduates. First, CD38 mRNA levels were correlated with lower Autism Quotient (AQ), indicating enhanced social skills. AQ assesses the extent of autistic-like traits including the propensity and dexterity needed for successful social engagement in the general population. Second, three CD157 eQTL SNPs in the CD38/CD157 gene region were associated with CD38 expression. CD157 is a paralogue of CD38 and is contiguous with it on chromosome 4p15. Third, association was also observed between the CD157 eQTL SNPs, CD38 expression and AQ. In the full model, CD38 expression and CD157 eQTL SNPs altogether account for a substantial 14% of the variance in sociality. Fourth, functionality of CD157 eQTL SNPs was suggested by a significant association with plasma oxytocin immunoreactivity products. Fifth, the ecological validity of these findings was demonstrated with subjects with higher PBL CD38 expression having more friends, especially for males. Furthermore, CD157 sequence variation predicts scores on the Friendship questionnaire. To summarize, this study by uniquely leveraging various measures reveals salient elements contributing to nonkin sociality and friendship, revealing a likely pathway underpinning the transition from normality to psychopathology. Copyright © 2017 Elsevier Ltd. All rights reserved.

Home Learning, Technology, and Tomorrow's Workplace.

Science.gov (United States)

Rieseberg, Rhonda L.

1995-01-01

Discusses characteristics and trends of home schools and workplaces. Use of computers and computer applications (CD-ROMS, interactive software, and networking) in home schooling provides a compatible environment for future home-based businesses and telecommuting trends. Sidebars include information on home schools on line; standardized test…

78 FR 67449 - Qualification of Drivers; Exemption Applications; Epilepsy and Seizure Disorders

Science.gov (United States)

2013-11-12

... epilepsy or a seizure disorder should be allowed to operate a CMV.\\3\\ The MEP recommendations are included...-0094; FMCSA- 2013-0107] Qualification of Drivers; Exemption Applications; Epilepsy and Seizure... ``Evidence Report on Seizure Disorders and Commercial Vehicle Driving'' (Evidence Report) [CD-ROM HD TL230.3...

A Fuel-Sensitive Reduced-Order Model (ROM) for Piston Engine Scaling Analysis

Science.gov (United States)

2017-09-29

of high Reynolds number nonreacting and reacting JP-8 sprays in a constant pressure flow vessel with a detailed chemistry approach . J Energy Resour...for rapid grid generation applied to in-cylinder diesel engine simulations. Society of Automotive Engineers ; 2007 Apr. SAE Technical Paper No.: 2007...ARL-TR-8172 ● Sep 2017 US Army Research Laboratory A Fuel-Sensitive Reduced-Order Model (ROM) for Piston Engine Scaling Analysis

Introducing students to ocean modeling via a web-based implementation for the Regional Ocean Modeling System (ROMS) river plume case study

Science.gov (United States)

Harris, C. K.; Overeem, I.; Hutton, E.; Moriarty, J.; Wiberg, P.

2016-12-01

Numerical models are increasingly used for both research and applied sciences, and it is important that we train students to run models and analyze model data. This is especially true within oceanographic sciences, many of which use hydrodynamic models to address oceanographic transport problems. These models, however, often require a fair amount of training and computer skills before a student can run the models and analyze the large data sets produced by the models. One example is the Regional Ocean Modeling System (ROMS), an open source, three-dimensional primitive equation hydrodynamic ocean model that uses a structured curvilinear horizontal grid. It currently has thousands of users worldwide, and the full model includes modules for sediment transport and biogeochemistry, and several options for turbulence closures and numerical schemes. Implementing ROMS can be challenging to students, however, in part because the code was designed to provide flexibility for the choice of model parameterizations and processes, and to run on a variety of High Performance Computing (HPC) platforms. To provide a more accessible tool for classroom use, we have modified an existing idealized ROMS implementation to be run on a High Performance Computer (HPC) via the WMT (Web Modeling Toolkit), and developed a series of lesson plans that explore sediment transport within the idealized model domain. This has addressed our goal to provide a relatively easy introduction to the numerical modeling process that can be used within upper level undergraduate and graduate classes to explore sediment transport on continental shelves. The model implementation includes wave forcing, along-shelf currents, a riverine source, and suspended sediment transport. The model calculates suspended transport and deposition of sediment delivered to the continental shelf by a riverine flood. Lesson plans lead the students through running the model on a remote HPC, modifying the standard model. The lesson

A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

OpenAIRE

Paquette, Y; Doyon, L; Laperrière, A; Hanna, Z; Ball, J; Sekaly, R P; Jolicoeur, P

1992-01-01

The long terminal repeat from a thymotropic mouse mammary tumor virus variant, DMBA-LV, was used to drive the expression of two reporter genes, murine c-myc and human CD4, in transgenic mice. Expression was observed specifically in thymic immature cells. Expression of c-myc in these cells induced oligoclonal CD4+ CD8+ T-cell thymomas. Expression of human CD4 was restricted to thymic progenitor CD4- CD8- and CD4+ CD8+ T cells and was shut off in mature CD4+ CD8- and CD4- CD8+ T cells, known to...

Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations.

Science.gov (United States)

Sweiss, Nadera J; Salloum, Rafah; Gandhi, Seema; Ghandi, Seema; Alegre, Maria-Luisa; Sawaqed, Ray; Badaracco, Maria; Pursell, Kenneth; Pitrak, David; Baughman, Robert P; Moller, David R; Garcia, Joe G N; Niewold, Timothy B

2010-02-05

Sarcoidosis is a poorly understood chronic inflammatory condition. Infiltration of affected organs by lymphocytes is characteristic of sarcoidosis, however previous reports suggest that circulating lymphocyte counts are low in some patients with the disease. The goal of this study was to evaluate lymphocyte subsets in peripheral blood in a cohort of sarcoidosis patients to determine the prevalence, severity, and clinical features associated with lymphopenia in major lymphocyte subsets. Lymphocyte subsets in 28 sarcoid patients were analyzed using flow cytometry to determine the percentage of CD4, CD8, and CD19 positive cells. Greater than 50% of patients had abnormally low CD4, CD8, or CD19 counts (p<4x10(-10)). Lymphopenia was profound in some cases, and five of the patients had absolute CD4 counts below 200. CD4, CD8, and CD19 lymphocyte subset counts were significantly correlated (Spearman's rho 0.57, p = 0.0017), and 10 patients had low counts in all three subsets. Patients with severe organ system involvement including neurologic, cardiac, ocular, and advanced pulmonary disease had lower lymphocyte subset counts as a group than those patients with less severe manifestations (CD4 p = 0.0043, CD8 p = 0.026, CD19 p = 0.033). No significant relationships were observed between various medical therapies and lymphocyte counts, and lymphopenia was present in patients who were not receiving any medical therapy. Significant lymphopenia involving CD4, CD8, and CD19 positive cells was common in sarcoidosis patients and correlated with disease severity. Our findings suggest that lymphopenia relates more to disease pathology than medical treatment.

Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity.

Science.gov (United States)

Slobodin, Gleb; Ahmad, Mohammad Sheikh; Rosner, Itzhak; Peri, Regina; Rozenbaum, Michael; Kessel, Aharon; Toubi, Elias; Odeh, Majed

2010-01-01

The role and function of T regulatory (Treg) cells have not been fully investigated in patients with systemic sclerosis (SSc). Ten patients with SSc donated 20ml of peripheral blood. Activity (Valentini) and severity (Medsger) scores for SSc were calculated for all patients. Healthy volunteers (controls) were matched to each patient by gender and age. CD4(+) cells were separated using the MACS system. The numbers of Treg cells were estimated by flow cytometry after staining for CD4, CD25, and FoxP3 and calculated as patient-to-control ratio separately for each experiment. Correlations with activity and severity indices of the disease were performed. Twenty-four-hour production of TGF-beta and IL-10 by activated CD4(+) cells was measured by ELISA in culture supernatants. The numbers of Treg cells, expressed as patient-to-control ratio, correlated significantly with both activity and severity indices (r=0.71, p=0.034 and r=0.67, p=0.044, respectively). ELISA-measured production of TGF-beta and IL-10 by CD4(+) cells was similar in patients and controls. Increased numbers of Treg cells are present in patients with SSc, correlating with activity and severity of the disease. This expansion of Treg cells was not accompanied, however, by heightened TGF-beta or IL-10 production. Further studies to elaborate the causes and functional significance of Treg cell expansion in SSc are needed. 2010 Elsevier Inc. All rights reserved.

CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways.

Science.gov (United States)

Wang, Chaoqun; Fok, Kin Lam; Cai, Zhiming; Chen, Hao; Chan, Hsiao Chang

2017-01-10

CD147 null mutant male mice are infertile with arrested spermatogenesis and increased apoptotic germ cells. Our previous studies have shown that CD147 prevents apoptosis in mouse spermatocytes but not spermatogonia. However, the underlying mechanism remains elusive. In the present study, we aim to determine the CD147-regulated apoptotic pathway in mouse spermatocytes. Our results showed that immunodepletion of CD147 triggered apoptosis through extrinsic apoptotic pathway in mouse testis and spermatocyte cell line (GC-2 cells), accompanied by activation of non-canonical NFκB signaling and suppression of canonical NFκB signaling. Furthermore, CD147 was found to interact with TRAF2, a factor known to regulate NFκB and extrinsic apoptotic signaling, and interfering CD147 led to the decrease of TRAF2. Consistently, depletion of CD147 by CRISPR/Cas9 technique in GC-2 cells down-regulated TRAF2 and resulted in cell death with suppressed canonical NFκB and activated non-canonical NFκB signaling. On the contrary, interfering of CD147 had no effect on NFκB signaling pathways as well as TRAF2 protein level in mouse spermatogonia cell line (GC-1 cells). Taken together, these results suggested that CD147 plays a key role in reducing extrinsic apoptosis in spermatocytes, but not spermatogonia, through modulating NFκB signaling pathway.

Data base for early postfire succession in Northern Rocky Mountain forests

Science.gov (United States)

Peter F. Stickney; Robert B. Campbell

2000-01-01

Web site and CD-ROM include 21 pages of text plus electronic data for 55 succession sites including color plates, tables, and figures. Provides data on quantitative postfire changes of plant species and forest vegetation components for up to the first 25 years of secondary plant succession for 55 forest sites in northern Idaho and northwestern Montana. Cover (aerial...

Structuring spot, short and long term gas contracts; CD-ROM ed.

Energy Technology Data Exchange (ETDEWEB)

Gretener, N.M.

1996-05-01

A review of the core clauses of the modern natural gas purchase and sales contracts, was presented. There exists a wide variety of terms which can be used by a seller and a buyer to customize such a contract to suit particular circumstances. On the basis of length of term, gas contracts may classified as spot contracts having a term of 30 days or less, short term contracts having a term of 30 days to one to two years, and long term contracts having terms greater than two years. The three key elements which are applicable to all gas sales contracts are the contract price, the seller`s obligation to deliver, and the buyer`s obligation to accept. Other provisions that may be included in any gas sales contract in addition to the basic three were reviewed, including market pricing, load factor incentive pricing, seasonal pricing, pipeline demand charges, market shares, and the seller`s right to decontract.

Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells

International Nuclear Information System (INIS)

Tovar-Salazar, Adriana; Patterson-Bartlett, Julie; Jesser, Renee; Weinberg, Adriana

2010-01-01

CMV infection is characterized by high of frequencies of CD27 - CD28 - T cells. Here we demonstrate that CMV-specific CD4 + CD27 - CD28 - cells are regulatory T cells (T R ). CD4 + CD27 - CD28 - cells sorted from CMV-stimulated PBMC of CMV-seropositive donors inhibited de novo CMV-specific proliferation of autologous PBMC in a dose-dependent fashion. Compared with the entire CMV-stimulated CD4 + T-cell population, higher proportions of CD4 + CD27 - CD28 - T R expressed FoxP3, TGFβ, granzyme B, perforin, GITR and PD-1, lower proportions expressed CD127 and PD1-L and similar proportions expressed CD25, CTLA4, Fas-L and GITR-L. CMV-CD4 + CD27 - CD28 - T R expanded in response to IL-2, but not to CMV antigenic restimulation. The anti-proliferative effect of CMV-CD4 + CD27 - CD28 - T R significantly decreased after granzyme B or TGFβ inhibition. The CMV-CD4 + CD27 - CD28 - T R of HIV-infected and uninfected donors had similar phenotypes and anti-proliferative potency, but HIV-infected individuals had higher proportions of CMV-CD4 + CD27 - CD28 - T R . The CMV-CD4 + CD27 - CD28 - T R may contribute to the downregulation of CMV-specific and nonspecific immune responses of CMV-infected individuals.

Understanding arsenic incorporation in CdTe with atom probe tomography

Energy Technology Data Exchange (ETDEWEB)

Burton, G. L.; Diercks, D. R.; Ogedengbe, O. S.; Jayathilaka, P. A. R. D.; Edirisooriya, M.; Myers, T. H.; Zaunbrecher, K. N.; Moseley, J.; Barnes, T. M.; Gorman, B. P.

2018-08-01

Overcoming the open circuit voltage deficiency in Cadmium Telluride (CdTe) photovoltaics may be achieved by increasing p-type doping while maintaining or increasing minority carrier lifetimes. Here, routes to higher doping efficiency using arsenic are explored through an atomic scale understanding of dopant incorporation limits and activation in molecular beam epitaxy grown CdTe layers. Atom probe tomography reveals spatial segregation into nanometer scale clusters containing > 60 at% As for samples with arsenic incorporation levels greater than 7-8 x 10^17 cm-3. The presence of arsenic clusters was accompanied by crystal quality degradation, particularly the introduction of arsenic-enriched extended defects. Post-growth annealing treatments are shown to increase the size of the As precipitates and the amount of As within the precipitates.

High soluble CD30, CD25 and IL-6 may identify patients with worse survival in CD30+ cutaneous lymphomas and early mycosis fungoides

Science.gov (United States)

Kadin, Marshall E.; Pavlov, Igor; Delgado, Julio C.; Vonderheid, Eric C.

2011-01-01

Histopathology alone cannot predict outcome of patients with CD30+ primary cutaneous lymphoproliferative disorders (CD30CLPD) and early mycosis fungoides (MF). To test the hypothesis that serum cytokines/cytokine receptors provide prognostic information in these disorders, we measured soluble CD30 (sCD30), sCD25, and selected cytokines in cell cultures and sera of 116 patients with CD30CLPD and 96 patients with early MF followed up to 20 years. Significant positive correlation was found between sCD30 levels and sCD25, CD40L, IL-6, and IL-8, suggesting CD30+ neoplastic cells secrete these cytokines, but not Th2 cytokines. In vitro studies confirmed sCD30, sCD25, IL-6 and IL-8 are secreted by CD30CLPD-derived cell lines. CD30CLPD patients with above normal sCD30 and sCD25 had worse overall and disease-related survivals, but only sCD30 retained significance in Cox models that included advanced age. High sCD30 also identified patients with worse survival in early MF. Increased IL-6 and IL-8 correlated with poor disease-related survival in CD30CLPD patients, We conclude that: (1) neoplastic cells of some CD30CLPD patients do not resemble Th2 cells, (2) high serum sCD30, sCD25, IL-6, and perhaps IL-8 levels may provide prognostic information useful for patient management. PMID:22071475

Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations

Directory of Open Access Journals (Sweden)

Fakhri Hassouneh

2017-06-01

Full Text Available Immunosenescence is a progressive deterioration of the immune system with aging. It affects both innate and adaptive immunity limiting the response to pathogens and to vaccines. As chronic cytomegalovirus (CMV infection is probably one of the major driving forces of immunosenescence, and its persistent infection results in functional and phenotypic changes to the T-cell repertoire, the aim of this study was to analyze the effect of CMV-seropositivity and aging on the expression of CD300a and CD161 inhibitory receptors, along with the expression of CD57 marker on CD4+, CD8+, CD8+CD56+ (NKT-Like and CD4−CD8− (DN T-cell subsets. Our results showed that, regardless of the T-cell subset, CD57−CD161−CD300a+ T-cells expand with age in CMV-seropositive individuals, whereas CD57−CD161+CD300a+ T-cells decrease. Similarly, CD57+CD161−CD300a+ T-cells expand with age in CMV-seropositive individuals in all subsets except in DN cells and CD57−CD161+CD300a− T-cells decrease in all T-cell subsets except in CD4+ T-cells. Besides, in young individuals, CMV latent infection associates with the expansion of CD57+CD161−CD300a+CD4+, CD57−CD161−CD300a+CD4+, CD57+CD161−CD300a+CD8+, CD57−CD161−CD300a+CD8+, CD57+CD161−CD300a+NKT-like, and CD57+CD161−CD300a+DN T-cells. Moreover, in young individuals, CD161 expression on T-cells is not affected by CMV infection. Changes of CD161 expression were only associated with age in the context of CMV latent infection. Besides, CD300a+CD57+CD161+ and CD300a−CD57+CD161+ phenotypes were not found in any of the T-cell subsets studied except in the DN subpopulation, indicating that in the majority of T-cells, CD161 and CD57 do not co-express. Thus, our results show that CMV latent infection impact on the immune system depends on the age of the individual, highlighting the importance of including CMV serology in any study regarding immunosenescence.

Technology.

Science.gov (United States)

Online-Offline, 1998

1998-01-01

Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

Bringing Down the Barriers to Information Transfer (L’Abaissement des Barrieres s’Opposant au Transfert de l’Information)

Science.gov (United States)

1992-02-01

Others included CD-ROM, magnetic tape, Microfiche/microfilm, autocad, CPU, mylar and verbal . Table 2: Amount of Time Spent Acquiring and Using...Transportes y Comunicaciones - Biblioteca. Ministerio de Ohmas Publicas. Plaza dle San Juan de la Cruz s/n, 280(03 Madrid. Spain Mr MiJ. SCHRYER* Director

75 FR 80425 - Satellite Television Extension and Localism Act of 2010 and Satellite Home Viewer Extension and...

Science.gov (United States)

2010-12-22

... subject line of the message. Mail: [Optional: Include the mailing address for paper, disk or CD-ROM... this proceeding, the Commission adopted a new digital TV ILLR model that complies with the requirements... certifies that ``the rule will not, if promulgated, have a significant economic impact on a substantial...

Multimedia Distribution: A View from the Supply Side.

Science.gov (United States)

Kesten, Myles

1998-01-01

Describes how multimedia products start as ideas and go through the stages of design, production, manufacturing, and marketing. Highlights include corporate consolidation, market distribution in 1997, encyclopedias and the growing Internet trend, direct marketers and sales, CD-ROM and DVD (digital video disk), costs, and future directions. (AEF)

The Teacher's Guide to Classical Music for Dummies.

Science.gov (United States)

Hinckley, June; Barnicle, Stephan

1997-01-01

Presents a series of interesting and creative learning activities designed to enhance students understanding and appreciation of classical music. Although designed to work in conjunction with a CD-ROM, most of the electronic material (music selections, scores, brief biographies) is available in libraries. Learning activities include objectives and…

Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⁺ T cells.

Science.gov (United States)

Lv, Jiaoyan; Zou, Linlin; Zhao, Lina; Yang, Wei; Xiong, Yingluo; Li, Bingji; He, Rui

2015-09-01

Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema and abundant inflammatory infiltrates, primarily including neutrophils and CD8(+) T cells. The role of the LTB4 -BLT1 axis in contact dermatitis remains largely unknown. In this study, we found up-regulated gene expression of 5-lipoxygenase and leukotriene A4 hydrolase, two critical enzymes for LTB4 synthesis, BLT1 and elevated LTB4 levels in skin lesions of oxazolone (OXA)-induced contact dermatitis. BLT1 deficiency or blockade of LTB4 and BLT1 by the antagonists, bestatin and U-75302, respectively, in the elicitation phase caused significant decreases in ear swelling and skin-infiltrating neutrophils and CD8(+) T cells, which was accompanied by significantly reduced skin expression of CXCL1, CXCL2, interferon-γ and interleukin-1β. Furthermore, neutrophil depletion during the elicitation phase of OXA-induced contact dermatitis also caused significant decreases in ear swelling and CD8(+) T-cell infiltration accompanied by significantly decreased LTB4 synthesis and gene expression of CXCL2, interferon-γ and interleukin-1β. Importantly, subcutaneous injection of exogenous LTB4 restored the skin infiltration of CD8(+) T cells in neutrophil-depleted mice following OXA challenge. Collectively, our results demonstrate that the LTB4 -BLT1 axis contributes to OXA-induced contact dermatitis by mediating skin recruitment of neutrophils, which are a major source of LTB4 that sequentially direct CD8(+) T-cell homing to OXA-challenged skin. Hence, LTB4 and BLT1 could be potential therapeutic targets for the treatment of contact dermatitis. © 2015 John Wiley & Sons Ltd.

Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

OpenAIRE

Teruel, María; Simeón Aznar, Carmen Pilar; Broen, Jasper C.; Vonk, Madelon C.; Carreira, Patricia; Camps García, María Teresa; García-Portales, Rosa; Delgado-Frías, Esmeralda; Gallego, Maria; Espinosa Garriga, Gerard; Spanish Scleroderma Group; Beretta, Lorenzo; Airó, Paolo; Lunardi, Claudio; Riemekasten, Gabriela

2012-01-01

Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc). Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genot...

CD1 and major histocompatibility complex II molecules follow a different course during dendritic cell maturation

NARCIS (Netherlands)

van der Wel, Nicole N.; Sugita, Masahiko; Fluitsma, Donna M.; Cao, Xaiochun; Schreibelt, Gerty; Brenner, Michael B.; Peters, Peter J.

2003-01-01

The maturation of dendritic cells is accompanied by the redistribution of major histocompatibility complex (MHC) class II molecules from the lysosomal MHC class IT compartment to the plasma membrane to mediate presentation of peptide antigens. Besides MHC molecules, dendritic cells also express CD1

Marketing of Online and CD-ROM Databases.

Science.gov (United States)

King, Carol; Oppenheim, Charles

1994-01-01

A survey of 20 British electronic information vendors found that 95% considered marketing important and suggested that it is likely to become more intensive and aggressive as competition increases in the information industry. Analyzed advertisements from professional journals and direct mail literature for readability, structure, and information…

Pricing Software and Information on CD-ROM.

Science.gov (United States)

Gibbins, Patrick

1987-01-01

Examines the relationships between purchases of optical data disk products, publishers, and software suppliers. The discussion covers current pricing strategies for optical data disk software and information products, and possible future developments in marketing and pricing. (CLB)

The Collection Menasseh Ben Israel, CD-rom

NARCIS (Netherlands)

Haas, de J.J.M.; Offenberg, A.K.; Ootjers, M.G.

1998-01-01

The Bibliotheca Rosenthaliana, Department of Judaica and Hebraica, Amsterdam University Library, harbours many unique research collections. One of the most prominent consists of the editions printed in the seventeenth century by Menasseh Ben Israel (1604), who established the first Hebrew printing

Braiding simulation for TRM preforms (CD-ROM)

NARCIS (Netherlands)

Akkerman, Remko; Villa Rodriguez, B.H.

2006-01-01

Braiding is a manufacturing process that is increasingly being used to manufacture pre-forms for Resin Transfer Moulding. A fast simulation method is presented for the prediction of the fibre distribution on complex braided parts and complex kinetic situations (e.g. changes in velocity,

Korelasi Kadar Feritin dengan Jumlah CD4, CD8, dan Rasio CD4/CD8 pada Penyandang Talasemia Mayor Anak

Directory of Open Access Journals (Sweden)

Bonnie Arseno

2017-11-01

Hasil. Didapatkan jumlah CD4 absolut, CD4%, CD8 absolut dan rasio CD4/CD8 menurun. Selain itu, terdapat jumlah CD4 absolut, CD8 absolut dan CD8% meningkat. Pada kelompok usia ≤5 tahun, korelasi kadar feritin dengan CD8 absolut, CD8%, dan rasio CD4/CD8 berturut-turut menghasilkan koefisien korelasi 0,691, 0,557, -0,680, dan p<0,05. Sementara pada kelompok lama terapi ≤5 tahun korelasi kadar feritin dengan CD8 absolut, CD8%, dan rasio CD4/CD8 menghasilkan koefisien korelasi 0,709, 0,571, -0,726 dengan p<0,05. Kesimpulan. Tidak terdapat korelasi antara kadar feritin dengan jumlah CD4, CD8, rasio CD4/CD8. Peningkatan kadar feritin akan diikuti dengan peningkatan jumlah CD8 absolut dan CD8%, serta penurunan rasio CD4/CD8 pada penyandang talasemia mayor anak berdasar atas usia dan lama terapi ≤5 tahun.

Identification of Ag and Cd photoluminescence in $^{111}$Ag-doped GaN

CERN Document Server

Stötzler, A; Deicher, M

1999-01-01

In order to unambiguously identify the chemical nature of Cd and Ag related optical transitions in GaN, epitaxial GaN layers were implanted with the radioactive isotope $^{111}$Ag which decays into stable $^{111}$Cd. This chemical transmutation was monitored by photoluminescence (PL) spectroscopy. Being an element specific property, the half-life of this decay was used to establish the chemical assignment of the optical transitions to a specific defect. We found that the Ag related transitions consist of a series of four single lines (1.610, 1.600, 1.594, and 1.573 eV), each accompanied by two phonon replicas separated by 63 meV. Cd produces two PL bands centered at 2.7 and 3.2 eV. Additional Cd-related single transitions at 3.341, 3.328, and 3.249 eV have been observed. Exponential fits to the PL intensities yield half-lives of $t_{1/2}^{Ag}$= (7.61$\\pm$0.27) d and $t_{1/2}^{Cd}$=(7.60$\\pm$0.27) d, respectively, in good agreement with the half-life of $^{111}$Ag of 7.45 d. (13 refs).

Asociación entre relaciones románticas y la calidad de sueño percibida por jóvenes universitarios

OpenAIRE

EcheverrÍa-Palacio, Carlos-Mario

2013-01-01

Introducción: Uno de los aspectos con mayor variación durante la adolescencia es el sueño, el cual se ve afectado por factores biológicos así como por los estados afectivos y emocionales. En esta etapa, los individuos establecen sus primeras relaciones sentimentales románticas, vínculos esenciales para la maduración de las relaciones sociales y psicosexuales. Este trabajo busca determinar la asociación existente entre las relaciones sentimentales románticas y sus características, con la calid...

Modeling of Cd(II) sorption on mixed oxide

International Nuclear Information System (INIS)

Waseem, M.; Mustafa, S.; Naeem, A.; Shah, K.H.; Hussain, S.Y.; Safdar, M.

2011-01-01

Mixed oxide of iron and silicon (0.75 M Fe(OH)3:0.25 M SiO/sub 2/) was synthesized and characterized by various techniques like surface area analysis, point of zero charge (PZC), energy dispersive X-rays (EDX) spectroscopy, Thermogravimetric and differential thermal analysis (TG-DTA), Fourier transform infrared spectroscopy (FTIR) and X-rays diffraction (XRD) analysis. The uptake of Cd/sup 2+/ ions on mixed oxide increased with pH, temperature and metal ion concentration. Sorption data have been interpreted in terms of both Langmuir and Freundlich models. The Xm values at pH 7 are found to be almost twice as compared to pH 5. The values of both DH and DS were found to be positive indicating that the sorption process was endothermic and accompanied by the dehydration of Cd/sup 2+/. Further, the negative value of DG confirms the spontaneity of the reaction. The ion exchange mechanism was suggested to take place for each Cd/sup 2+/ ions at pH 5, whereas ion exchange was found coupled with non specific adsorption of metal cations at pH 7. (author)

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells.

Science.gov (United States)

Wang, Xiaomei; Su, Jin; Sherman, Alexandra; Rogers, Geoffrey L; Liao, Gongxian; Hoffman, Brad E; Leong, Kam W; Terhorst, Cox; Daniell, Henry; Herzog, Roland W

2015-04-09

Coagulation factor replacement therapy for the X-linked bleeding disorder hemophilia is severely complicated by antibody ("inhibitor") formation. We previously found that oral delivery to hemophilic mice of cholera toxin B subunit-coagulation factor fusion proteins expressed in chloroplasts of transgenic plants suppressed inhibitor formation directed against factors VIII and IX and anaphylaxis against factor IX (FIX). This observation and the relatively high concentration of antigen in the chloroplasts prompted us to evaluate the underlying tolerance mechanisms. The combination of oral delivery of bioencapsulated FIX and intravenous replacement therapy induced a complex, interleukin-10 (IL-10)-dependent, antigen-specific systemic immune suppression of pathogenic antibody formation (immunoglobulin [Ig] 1/inhibitors, IgE) in hemophilia B mice. Tolerance induction was also successful in preimmune mice but required prolonged oral delivery once replacement therapy was resumed. Orally delivered antigen, initially targeted to epithelial cells, was taken up by dendritic cells throughout the small intestine and additionally by F4/80(+) cells in the duodenum. Consistent with the immunomodulatory responses, frequencies of tolerogenic CD103(+) and plasmacytoid dendritic cells were increased. Ultimately, latency-associated peptide expressing CD4(+) regulatory T cells (CD4(+)CD25(-)LAP(+) cells with upregulated IL-10 and transforming growth factor-β (TGF-β) expression) as well as conventional CD4(+)CD25(+) regulatory T cells systemically suppressed anti-FIX responses. © 2015 by The American Society of Hematology.

Submesoscale Flows and Mixing in the Oceanic Surface Layer Using the Regional Oceanic Modeling System (ROMS)

Science.gov (United States)

2014-09-30

IMPACT/APPLICATIONS Geochemistry and Ecosystems: An important community use for ROMS is biogeochemisty: chemical cycles, water quality, blooms ...published, refereed] Colas, F., J.C. McWilliams, X. Capet, and J. Kurian, 2012: Heat balance and eddies in the Peru- Chile Current System. Climate

CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity.

Science.gov (United States)

Akane, Kazuyuki; Kojima, Seiji; Mak, Tak W; Shiku, Hiroshi; Suzuki, Haruhiko

2016-03-01

The Fas/FasL (CD95/CD178) system is required for immune regulation; however, it is unclear in which cells, when, and where Fas/FasL molecules act in the immune system. We found that CD8(+)CD122(+) cells, which are mostly composed of memory T cells in comparison with naïve cells in the CD8(+)CD122(-) population, were previously shown to include cells with regulatory activity and could be separated into CD49d(low) cells and CD49d(high) cells. We established in vitro and in vivo experimental systems to evaluate the regulatory activity of CD122(+) cells. Regulatory activity was observed in CD8(+)CD122(+)CD49d(low) but not in CD8(+)CD122(+)CD49d(high) cells, indicating that the regulatory cells in the CD8(+)CD122(+) population could be narrowed down to CD49d(low) cells. CD8(+)CD122(-) cells taken from lymphoproliferation (lpr) mice were resistant to regulation by normal CD122(+) Tregs. CD122(+) Tregs taken from generalized lymphoproliferative disease (gld) mice did not regulate wild-type CD8(+)CD122(-) cells, indicating that the regulation by CD122(+) Tregs is Fas/FasL-dependent. CD122(+) Tregs taken from IL-10-deficient mice could regulate CD8(+)CD122(-) cells as equally as wild-type CD122(+) Tregs both in vitro and in vivo. MHC class I-missing T cells were not regulated by CD122(+) Tregs in vitro. CD122(+) Tregs also regulated CD4(+) cells in a Fas/FasL-dependent manner in vitro. These results suggest an essential role of Fas/FasL as a terminal effector of the CD122(+) Tregs that kill activated T cells to maintain immune homeostasis.

A case of Fanconi syndrome accompanied by crystal depositions in tubular cells in a patient with multiple myeloma

Directory of Open Access Journals (Sweden)

Do Hee Kim

2014-06-01

Full Text Available Fanconi syndrome (FS is a rare condition that is characterized by defects in the proximal tubular function. A 48-year-old woman was admitted for evaluation of proteinuria. The patient showed normal anion gap acidosis, normoglycemic glycosuria, hypophosphatemia, and hypouricemia. Thus, her condition was compatible with FS. The M peak was found behind the beta globulin region in urine protein electrophoresis. Upon bone marrow examination, we found that 24% of cells were CD138+ plasma cells with kappa restriction. From a kidney biopsy, we found crystalline inclusions within proximal tubular epithelial cells. Thereafter, she was diagnosed with FS accompanied by multiple myeloma. The patient received chemotherapy and autologous stem cell transplantation, and obtained very good partial hematologic response. However, proximal tubular dysfunction was persistent until 1 year after autologous stem cell transplantation. In short, we report a case of FS accompanied by multiple myeloma, demonstrating crystalline inclusion in proximal tubular cells on kidney biopsy.

Regulatory B cells (CD19(+)CD38(hi)CD24(hi)) in alloimmunized and non-alloimmunized children with β-thalassemia major.

Science.gov (United States)

Zahran, Asmaa M; Elsayh, Khalid I; Saad, Khaled; Embaby, Mostafa; Ali, Ahmed M

2016-03-01

β-Thalassemia major (BTM) is considered the most common hemoglobinopathy in Egypt and is one of the major health problems in our locality. We investigated the frequency of B-regulatory cells (CD19(+)CD38(hi)CD24(hi)); (Bregs) among polytransfused alloimmunized and non-alloimmunized children with BTM. The study included 110 polytransfused pediatric patients with β-thalassemia major. Clinical and transfusion records of all studied patients were reviewed. Indirect antiglobulin test was performed to detect the presence of alloantibodies. We used flow cytometry for detection of CD19(+)CD38(hi)CD24(hi) regulatory B cells. Alloimmunization was detected in 35.5% of thalassemic patients (39/110). The analysis of our data showed a significantly higher frequency of Bregs (CD19(+)CD38(hi)CD24(hi)) in the peripheral blood of both alloimmunized and non-alloimmunized patients as compared to healthy controls. Our data showed that the frequencies of CD19(+)CD24(hi)CD38(hi) Bregs cells were significantly increased in children with BTM. Our data suggested that Bregs cells could play a role in the clinical course of BTM. The relationship of Bregs to immune disorders in BTM children remains to be determined. Further longitudinal study with a larger sample size is warranted to explore the mechanisms of Breg cells in the disease process in BTM patients. Copyright © 2016 Elsevier Inc. All rights reserved.

Synthesis and Characterization of CdS/CdSxSe1-x Nanowires

Science.gov (United States)

Agueda Lopez, Kleyser; Wu, Marvin

Semiconductor nanowire heterostructures are of interest for potential applications in solar cells and other advanced optoelectronic devices. We report here on synthesis of CdS/CdSxSe1-x nanowires (NWs) using a dual source vapor = liquid - solid technique, and characterization of these NWs with scanning electron microscopy and optical microscopy. We determine the effect of growth parameters, including source / substrate temperatures and time of exposure, on NW size, shape, and composition. The crystal structure and optical properties individual NWs from selected substrates has been mapped using transmission Kikuchi diffraction and photoluminescence (PL) microscopy. NWs consistently exhibit a hexagonal structure, with growth along the c-axis. Strong PL peaks are observed between the expected bandgap emission from CdS and CdSe, confirming formation of CdSxSe1-x. PL peaks vary significantly with intensity along the long axis of the nanowire, suggesting that the NW surface is not uniformly passivated. These nanowires show promise for future investigation and manipulation of energy band gaps contain in CdS/CdSe. CREST.

Increased memory phenotypes of CD4+ and CD8+ T cells in ...

African Journals Online (AJOL)

Conclusions: Children with SCA in Tanzania show an absolute increase in all leukocyte types, including lymphocytes, with skewing of both CD4+ and CD8+ T cells towards the memory phenotypes. These findings provide insights on the development of adaptive immunity which may have implications on vaccine ...

Frequency of CD4+CD25+Foxp3+ cells in peripheral blood in relation to urinary bladder cancer malignancy indicators before and after surgical removal.

Science.gov (United States)

Jóźwicki, Wojciech; Brożyna, Anna A; Siekiera, Jerzy; Slominski, Andrzej T

2016-03-08

Tumor cells communicate with stromal cells, including cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs), to form microenvironment inhibiting immune responses. Regulatory T cells (Tregs, CD4+CD25+FoxP3+) stimulate immune tolerance and facilitate tumor progression. We analyzed the changes in Treg frequencies assessed using flow cytometry in the peripheral blood of patients with urothelial bladder cancer before and after tumor-removal. Changes in Treg frequency were investigated in relation to clinicopathomorphological indicators of tumor malignancy and expression of RCAS1 on CAFs and TAMs. Higher Treg frequencies were observed in early phase of tumor growth (pTa-pT2), in larger tumors, with more aggressive type of invasion, and with expression of RCAS1. The later phase of tumor development, accompanied by a nonclassic differentiations and pT3-pT4 advancement, had lower number of tumor infiltrating lymphocytes (TILs) and lower Treg frequency. Furthermore, in pT2-pT4 tumors, a decreased post-surgery Treg frequency was associated with poorer prognosis: patients with the lowest frequency of Tregs died first. These findings strongly suggest that the Treg frequencies at later phase of tumor growth, associated with a low anti-tumor response, represent a new and important prognostic indicator in urinary bladder cancer.

The Elementary School Library Collection: A Guide to Books and Other Media, Phases 1-2-3. 20th Edition.

Science.gov (United States)

Homa, Linda L., Ed.; And Others

This collection development aid lists more than 10,000 titles of children's materials available in a variety of formats (in addition to print materials, the guide also includes sound recordings, video cassettes, microcomputer software programs, CD-ROM products, and videodiscs). This 20th anniversary edition contains several special features,…

International Atomic Energy Agency Publications. Catalogue 1986-1999

International Nuclear Information System (INIS)

2000-11-01

This catalogue lists all sales publications of the International Atomic Energy Agency issued from 1986 up to the end of 1999 and still available. Some earlier titles which form part of an established series or are still considered important have also been included. The catalogue is in CD-ROM format

Potentials of E-Learning as a Study Tool in Business Education in Nigerian Schools

Science.gov (United States)

Ojeaga, I. J.; Igbinedion, V. I.

2012-01-01

With advancement in information technology in the 21st century, e-learning has become an invaluable technology for teaching, learning and research in education. E-learning involves the use of technology to enhance learning including digital collaboration, satellite broadcasting, CD-ROMs amongst others. E-learning has so many advantages over the…

Elektronische Informationsdienste im Bildungswesen (Electronic Information Services in Education) Gesellschaft Information Bildung Conference (GIB) (2nd, Berlin, Germany, November 17-18, 1994).

Science.gov (United States)

Diepold, Peter, Ed.; Rusch-Feja, Diann, Ed.

These papers on educational technology were presented in three workshops at the second annual conference of the Society of Information Education (GIB). Discussion includes electronic networks, CD-ROMs, and online databases in education, the quality of educational software, database services and instructional methods, and the use of the Internet in…

Leukotriene B4—leukotriene B4 receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8+ T cells

Science.gov (United States)

Lv, Jiaoyan; Zou, Linlin; Zhao, Lina; Yang, Wei; Xiong, Yingluo; Li, Bingji; He, Rui

2015-01-01

Leukotriene B4 (LTB4) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema and abundant inflammatory infiltrates, primarily including neutrophils and CD8+ T cells. The role of the LTB4–BLT1 axis in contact dermatitis remains largely unknown. In this study, we found up-regulated gene expression of 5-lipoxygenase and leukotriene A4 hydrolase, two critical enzymes for LTB4 synthesis, BLT1 and elevated LTB4 levels in skin lesions of oxazolone (OXA)-induced contact dermatitis. BLT1 deficiency or blockade of LTB4 and BLT1 by the antagonists, bestatin and U-75302, respectively, in the elicitation phase caused significant decreases in ear swelling and skin-infiltrating neutrophils and CD8+ T cells, which was accompanied by significantly reduced skin expression of CXCL1, CXCL2, interferon-γ and interleukin-1β. Furthermore, neutrophil depletion during the elicitation phase of OXA-induced contact dermatitis also caused significant decreases in ear swelling and CD8+ T-cell infiltration accompanied by significantly decreased LTB4 synthesis and gene expression of CXCL2, interferon-γ and interleukin-1β. Importantly, subcutaneous injection of exogenous LTB4 restored the skin infiltration of CD8+ T cells in neutrophil-depleted mice following OXA challenge. Collectively, our results demonstrate that the LTB4–BLT1 axis contributes to OXA-induced contact dermatitis by mediating skin recruitment of neutrophils, which are a major source of LTB4 that sequentially direct CD8+ T-cell homing to OXA-challenged skin. Hence, LTB4 and BLT1 could be potential therapeutic targets for the treatment of contact dermatitis. PMID:25959240

A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.

Science.gov (United States)

Liu, Jin-Qing; Talebian, Fatemeh; Wu, Lisha; Liu, Zhihao; Li, Ming-Song; Wu, Laichu; Zhu, Jianmin; Markowitz, Joseph; Carson, William E; Basu, Sujit; Bai, Xue-Feng

2016-08-15

CD200 is a cell surface glycoprotein that functions through engaging CD200R on cells of the myeloid lineage and inhibits their functions. Expression of CD200 was implicated in a variety of human cancer cells, including melanoma cells; however, its roles in tumor growth and immunity are not clearly understood. In this study, we used CD200R-deficient mice and the B16 tumor model to evaluate this issue. We found that CD200R-deficient mice exhibited accelerated growth of CD200(+), but not CD200(-), B16 tumors. Strikingly, CD200R-deficient mice receiving CD200(+) B16 cells i.v. exhibited massive tumor growth in multiple organs, including liver, lung, kidney, and peritoneal cavity, whereas the growth of the same tumors in wild-type mice was limited. CD200(+) tumors grown in CD200R-deficient mice contained higher numbers of CD11b(+)Ly6C(+) myeloid cells, exhibited increased expression of VEGF and HIF1α genes with increased angiogenesis, and showed significantly reduced infiltration of CD4(+) and CD8(+) T cells, presumably as the result of reduced expression of T cell chemokines, such as CXCL9 and CXCL16. The liver from CD200R-deficient mice, under metastatic growth of CD200(+) tumors, contained significantly increased numbers of CD11b(+)Gr1(-) myeloid cells and Foxp3(+) regulatory T cells and reduced numbers of NK cells. Liver T cells also had a reduced capacity to produce IFN-γ or TNF-α. Taken together, we revealed a critical role for CD200R signaling in limiting the growth and metastasis of CD200(+) tumors. Thus, targeting CD200R signaling may potentially interfere with the metastatic growth of CD200(+) tumors, like melanoma. Copyright © 2016 by The American Association of Immunologists, Inc.

Electronic publishing of SPE papers

International Nuclear Information System (INIS)

Perdue, J.M.

1992-01-01

This paper reports that the SPE is creating an electronic index to over 25,000 technical papers and will produce a CD-ROM as an initial product. This SPE CD-ROM Masterdisc will be available at the SPE Annual Meeting in Washington, D.C. on October 4-7, 1992. The SPE Board has appointed an Ad Hoc Committee on Electronic Publishing to coordinate and oversee this project and to recommend authoring standards for submitting SPE papers electronically in the future

Comparing a quasi-3D to a full 3D nearshore circulation model: SHORECIRC and ROMS

Science.gov (United States)

Haas, Kevin A.; Warner, John C.

2009-01-01

Predictions of nearshore and surf zone processes are important for determining coastal circulation, impacts of storms, navigation, and recreational safety. Numerical modeling of these systems facilitates advancements in our understanding of coastal changes and can provide predictive capabilities for resource managers. There exists many nearshore coastal circulation models, however they are mostly limited or typically only applied as depth integrated models. SHORECIRC is an established surf zone circulation model that is quasi-3D to allow the effect of the variability in the vertical structure of the currents while maintaining the computational advantage of a 2DH model. Here we compare SHORECIRC to ROMS, a fully 3D ocean circulation model which now includes a three dimensional formulation for the wave-driven flows. We compare the models with three different test applications for: (i) spectral waves approaching a plane beach with an oblique angle of incidence; (ii) monochromatic waves driving longshore currents in a laboratory basin; and (iii) monochromatic waves on a barred beach with rip channels in a laboratory basin. Results identify that the models are very similar for the depth integrated flows and qualitatively consistent for the vertically varying components. The differences are primarily the result of the vertically varying radiation stress utilized by ROMS and the utilization of long wave theory for the radiation stress formulation in vertical varying momentum balance by SHORECIRC. The quasi-3D model is faster, however the applicability of the fully 3D model allows it to extend over a broader range of processes, temporal, and spatial scales.

Soluble CD30 in normotensive pregnant women with isolated fetal intrauterine growth restriction: a comparison with preeclamptic women.

Science.gov (United States)

Laskowska, Marzena; Laskowska, Katarzyna; Oleszczuk, Jan

2010-11-01

This study investigated the serum concentration of soluble CD30 (sCD30) in pregnant women with isolated fetal intrauterine growth restriction, in pregnancies complicated by preeclampsia with and without accompanying intrauterine growth restriction, and in normotensive healthy pregnant controls. Lower serum concentrations of sCD30 were observed in the group of normotensive pregnant women with a growth-restricted fetus in comparison with the group of healthy pregnant controls, and also in comparison with both preeclamptic groups of pregnant women with and without fetal growth restriction. The concentration of sCD30 in maternal serum from preeclamptic women did not differ in comparison with values from healthy controls or pregnancies complicated by isolated fetal intrauterine growth restriction. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Research Upregulation of CD23 (FcεRII Expression in Human Airway Smooth Muscle Cells (huASMC in Response to IL-4, GM-CSF, and IL-4/GM-CSF

Directory of Open Access Journals (Sweden)

Lew D Betty

2005-05-01

Full Text Available Abstract Background Airway smooth muscle cells play a key role in remodeling that contributes to airway hyperreactivity. Airway smooth muscle remodeling includes hypertrophy and hyperplasia. It has been previously shown that the expression of CD23 on ASMC in rabbits can be induced by the IgE component of the atopic serum. We examined if other components of atopic serum are capable of inducing CD23 expression independent of IgE. Methods Serum starved huASMC were stimulated with either IL-4, GM-CSF, IL-13, IL-5, PGD2, LTD4, tryptase or a combination of IL-4, IL-5, IL-13 each with GM-CSF for a period of 24 h. CD23 expression was analyzed by flow cytometry, western blot, and indirect immunofluorescence. Results The CD23 protein expression was upregulated in huASMC in response to IL-4, GM-CSF, and IL-4/GM-CSF. The percentage of cells with increased fluorescence intensity above the control was 25.1 ± 4.2% (IL-4, 15.6 ± 2.7% (GM-CSF and 32.9 ± 13.9% (IL-4/GMCSF combination(n = 3. The protein content of IL-4/GMCSF stimulated cells was significantly elevated. Expression of CD23 in response to IL-4, GM-CSF, IL-4/GM-CSF was accompanied by changes in cell morphology including depolymerization of isoactin fibers, cell spreading, and membrane ruffling. Western blot revealed abundant expression of the IL-4Rα and a low level expression of IL-2Rγc in huASMC. Stimulation with IL-4 resulted in the phosphorylation of STAT-6 and an increase in the expression of the IL-2Rγc. Conclusion CD23 on huASMC is upregulated by IL-4, GM-CSF, and IL-4/GM-CSF. The expression of CD23 is accompanied by an increase in cell volume and an increase in protein content per cell, suggesting hypertrophy. Upregulation of CD23 by IL-4/GM-CSF results in phenotypic changes in huASMC that could play a role in cell migration or a change in the synthetic function of the cells. Upregulation of CD23 in huASMC by IL-4 and GM-CSF can contribute to changes in huASMC and may provide an avenue

Delicacy, Imprecision, and Uncertainty of Oceanic Simulations: An Investigation with the Regional Oceanic Modeling System (ROMS)

Science.gov (United States)

2013-09-30

Geochemistry and Ecosystems: An important community use for ROMS is biogeochemisty: chemical cycles, water quality, blooms , micro-nutrients, larval...Sci., submitted. Colas, F., J.C. McWilliams, X. Capet, and J. Kurian, 2012: Heat balance and eddies in the Peru- Chile Current System. Climate

Surface passivation for CdTe devices

Energy Technology Data Exchange (ETDEWEB)

Reese, Matthew O.; Perkins, Craig L.; Burst, James M.; Gessert, Timothy A.; Barnes, Teresa M.; Metzger, Wyatt K.

2017-08-01

In one embodiment, a method for surface passivation for CdTe devices is provided. The method includes adjusting a stoichiometry of a surface of a CdTe material layer such that the surface becomes at least one of stoichiometric or Cd-rich; and reconstructing a crystalline lattice at the surface of the CdTe material layer by annealing the adjusted surface.

Different thresholds of T cell activation regulate FIV infection of CD4+CD25+ and CD4+CD25- cells

International Nuclear Information System (INIS)

Joshi, Anjali; Garg, Himanshu; Tompkins, Mary B.; Tompkins, Wayne A.

2005-01-01

Cellular activation plays an important role in retroviral replication. Previously, we have shown that CD4 + CD25 + T cells by the virtue of their partially activated phenotype represent ideal candidates for a productive feline immunodeficiency virus (FIV) infection. In the present study, we extended our previous observations with regard to FIV replication in CD4 + CD25 + and CD4 + CD25 - cells under different stimulation conditions. Both CD4 + CD25 + and CD4 + CD25 - cells remain latently infected in the absence of IL-2 or concanvalinA (ConA), respectively; harboring a replication competent provirus capable of reactivation several days post-infection. While CD4 + CD25 + cells require low levels of exogenous IL-2 and virus inputs for an efficient FIV replication, CD4 + CD25 - T cells can only be productively infected in the presence of either high concentrations of IL-2 or high virus titers, even in the absence of mitogenic stimulation. Interestingly, while high virus input activates CD4 + CD25 - cells to replicate FIV, it induces apoptosis in a high percentage of CD4 + CD25 + T cells. High IL-2 concentrations but not high virus inputs lead to surface upregulation of CD25 and significant cellular proliferation in CD4 + CD25 - cells. These results suggest that CD4 + CD25 + and CD4 + CD25 - T cells have different activation requirements which can be modulated by both viral and cytokine stimuli to reach threshold activation levels in order to harbor a productive FIV infection. This holds implications in vivo for CD4 + CD25 + and CD4 + CD25 - cells to serve as potential reservoirs of a productive and latent FIV infection

Effect of Ankle Range of Motion (ROM) and Lower-Extremity Muscle Strength on Static Balance Control Ability in Young Adults: A Regression Analysis

Science.gov (United States)

Kim, Seong-Gil

2018-01-01

Background The purpose of this study was to investigate the effect of ankle ROM and lower-extremity muscle strength on static balance control ability in young adults. Material/Methods This study was conducted with 65 young adults, but 10 young adults dropped out during the measurement, so 55 young adults (male: 19, female: 36) completed the study. Postural sway (length and velocity) was measured with eyes open and closed, and ankle ROM (AROM and PROM of dorsiflexion and plantarflexion) and lower-extremity muscle strength (flexor and extensor of hip, knee, and ankle joint) were measured. Pearson correlation coefficient was used to examine the correlation between variables and static balance ability. Simple linear regression analysis and multiple linear regression analysis were used to examine the effect of variables on static balance ability. Results In correlation analysis, plantarflexion ROM (AROM and PROM) and lower-extremity muscle strength (except hip extensor) were significantly correlated with postural sway (pregression analysis, plantar flexion PROM with eyes open significantly influenced sway length (B=0.681) and sway velocity (B=0.011). Conclusions Lower-extremity muscle strength and ankle plantarflexion ROM influenced static balance control ability, with ankle plantarflexion PROM showing the greatest influence. Therefore, both contractile structures and non-contractile structures should be of interest when considering static balance control ability improvement. PMID:29760375

Are you dyslexic?

CERN Multimedia

2003-01-01

If so, read this article. You may be able to help children with the same disability as you. The BBC and the charity Dyslexia International Tools and Technologies (DITT) are currently producing a CD-ROM for dyslexic children aged 9 to 14. One of the aims is to offer them encouragement by showing them that people with dyslexia have made successes of their lives. The BBC is therefore looking for people from all over Europe who have succeeded despite their condition. The CD-ROM will be translated into several different languages and distributed throughout Europe. If you are a high-level physicist with dyslexia, you could take part in the making of this CD-Rom. The BBC will be coming to film 10-minute interviews about people's experience with dyslexia and the advice they can offer to young people suffering from the same condition. Please send an e-mail to James.Gillies@cern.ch as soon as possible.

EOSDIS Terra Data Sampler #1: Western US Wildfires 2000. 1.1

Science.gov (United States)

Perkins, Dorothy C. (Technical Monitor)

2000-01-01

This CD-ROM contains sample data in HDF-EOS format from the instruments on board the Earth Observing System (EOS) Terra satellite: (1) Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER); (2) Clouds and the Earth's Radiant Energy System (CERES); (3) Multi-angle Imaging Spectroradiometer (MISR); and (4) Moderate Resolution Imaging Spectroradiometer (MODIS). Data from the Measurements of Pollution in the Troposphere (MOPITT) instrument were not available for distribution (as of October 17, 2000). The remotely sensed, coincident data for the Western US wildfires were acquired August 30, 2000. This CD-ROM provides information about the Terra mission, instruments, data, and viewing tools. It also provides the Collage tool for viewing data, and links to Web sites containing other digital data processing software. Full granules of the data on this CD-ROM and other EOS Data and Information System (EOSDIS) data products are available from the NASA Distributed Active Archive Centers (DAACs).

Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis.

Science.gov (United States)

Postigo, Jorge; Iglesias, Marcos; Cerezo-Wallis, Daniela; Rosal-Vela, Antonio; García-Rodríguez, Sonia; Zubiaur, Mercedes; Sancho, Jaime; Merino, Ramón; Merino, Jesús

2012-01-01

CD38, a type II transmembrane glycoprotein expressed in many cells of the immune system, is involved in cell signaling, migration and differentiation. Studies in CD38 deficient mice (CD38 KO mice) indicate that this molecule controls inflammatory immune responses, although its involvement in these responses depends on the disease model analyzed. Here, we explored the role of CD38 in the control of autoimmune responses using chicken collagen type II (col II) immunized C57BL/6-CD38 KO mice as a model of collagen-induced arthritis (CIA). We demonstrate that CD38 KO mice develop an attenuated CIA that is accompanied by a limited joint induction of IL-1β and IL-6 expression, by the lack of induction of IFNγ expression in the joints and by a reduction in the percentages of invariant NKT (iNKT) cells in the spleen. Immunized CD38 KO mice produce high levels of circulating IgG1 and low of IgG2a anti-col II antibodies in association with reduced percentages of Th1 cells in the draining lymph nodes. Altogether, our results show that CD38 participates in the pathogenesis of CIA controlling the number of iNKT cells and promoting Th1 inflammatory responses.

Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis.

Directory of Open Access Journals (Sweden)

Jorge Postigo

Full Text Available CD38, a type II transmembrane glycoprotein expressed in many cells of the immune system, is involved in cell signaling, migration and differentiation. Studies in CD38 deficient mice (CD38 KO mice indicate that this molecule controls inflammatory immune responses, although its involvement in these responses depends on the disease model analyzed. Here, we explored the role of CD38 in the control of autoimmune responses using chicken collagen type II (col II immunized C57BL/6-CD38 KO mice as a model of collagen-induced arthritis (CIA. We demonstrate that CD38 KO mice develop an attenuated CIA that is accompanied by a limited joint induction of IL-1β and IL-6 expression, by the lack of induction of IFNγ expression in the joints and by a reduction in the percentages of invariant NKT (iNKT cells in the spleen. Immunized CD38 KO mice produce high levels of circulating IgG1 and low of IgG2a anti-col II antibodies in association with reduced percentages of Th1 cells in the draining lymph nodes. Altogether, our results show that CD38 participates in the pathogenesis of CIA controlling the number of iNKT cells and promoting Th1 inflammatory responses.

Mi-spillet

DEFF Research Database (Denmark)

Larsen, Lea Lund; Hejlesen, Stine

2003-01-01

MI-spillet er et undervisningsspil til folkeskolens mellemtrin og udskolingen. Spillet omformer Howard Gardners teori om de mange intelligenser til et praktisk og håndgribeligt værktøj til brug i folkeskolen. Spillet indeholder et undervisningsmateriale bestående af lærervejledning og kopimappe...... emnebaseret eller tværfagligt arbejde. Alt materialet ligger samlet på en cd-rom, hvorfra materialet printes. Skolen kan derfor ved køb af én cd-rom printe og producere et ubegrænset antal spil. Cd-rommen indeholder: 1. Lærervejledning 2. MI-spillet * Gulvpladerne * Spørgsmål til spillet * Bilag til...

Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity

Directory of Open Access Journals (Sweden)

Astrid M. Westendorf

2017-03-01

Full Text Available Background/Aims: Hypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment. Methods: Colitis-associated colon cancer was induced in wildtype mice, and hypoxia as well as T cell immunity were analysed in the colonic tumour tissues. In addition, CD4+ effector T cells and regulatory T cells were cultured under normoxic and hypoxic conditions and examined regarding their phenotype and function. Results: We observed severe hypoxia in the colon of mice suffering from colitis-associated colon cancer that was accompanied by a reduced differentiation of CD4+ effector T cells and an enhanced number and suppressive activity of regulatory T cells. Complementary ex vivo and in vitro studies revealed that T cell stimulation under hypoxic conditions inhibited the differentiation, proliferation and IFN-γ production of TH1 cells and enhanced the suppressive capacity of regulatory T cells. Moreover, we identified an active role for HIF-1α in the modulation of CD4+ T cell functions under hypoxic conditions. Conclusion: Our data indicate that oxygen availability can function as a local modulator of CD4+ T cell responses and thus influences tumour immune surveillance in inflammation-associated colon cancer.

CD38+ M-MDSC expansion characterizes a subset of advanced colorectal cancer patients.

Science.gov (United States)

Karakasheva, Tatiana A; Dominguez, George A; Hashimoto, Ayumi; Lin, Eric W; Chiu, Christopher; Sasser, Kate; Lee, Jae W; Beatty, Gregory L; Gabrilovich, Dmitry I; Rustgi, Anil K

2018-03-22

Myeloid-derived suppressor cells (MDSCs) are a population of immature immune cells with several protumorigenic functions. CD38 is a transmembrane receptor-ectoenzyme expressed by MDSCs in murine models of esophageal cancer. We hypothesized that CD38 could be expressed on MDSCs in human colorectal cancer (CRC), which might allow for a new perspective on therapeutic targeting of human MDSCs with anti-CD38 monoclonal antibodies in this cancer. Blood samples were collected from 41 CRC patients and 8 healthy donors, followed by peripheral blood mononuclear cell (PBMC) separation. Polymorphonuclear (PMN-) and monocytic (M-) MDSCs and CD38 expression levels were quantified by flow cytometry. The immunosuppressive capacity of M-MDSCs from 10 CRC patients was validated in a mixed lymphocyte reaction (MLR) assay. A significant expansion of CD38+ M-MDSCs and a trend of expansion of CD38+ PMN-MDSCs (accompanied by a trend of increased CD38 expression on both M- and PMN-MDSCs) were observed in PBMCs of CRC patients when compared with healthy donors. The CD38+ M-MDSCs from CRC patients were found to be immunosuppressive when compared with mature monocytes. CD38+ M- and PMN-MDSC frequencies were significantly higher in CRC patients who previously received treatment when compared with treatment-naive patients. This study provides a rationale for an attempt to target M-MDSCs with an anti-CD38 monoclonal antibody in metastatic CRC patients. NCI P01-CA14305603, the American Cancer Society, Scott and Suzi Lustgarten Family Colon Cancer Research Fund, Hansen Foundation, and Janssen Research and Development.

RHEED studies of MBE growth mechanisms of CdTe and CdMnTe

Energy Technology Data Exchange (ETDEWEB)

Waag, A.; Behr, T.; Litz, T.; Kuhn-Heinrich, B.; Hommel, D.; Landwehr, G. (Physikalisches Inst., Univ. Wuerzburg (Germany))

1993-01-30

We report on reflection high energy electron diffraction (RHEED) studies of molecular beam epitaxy (MBE) growth of CdTe and CdMnTe on (100) oriented CdTe substrates. RHEED oscillations were measured for both the growth and desorption of CdTe and CdMnTe as a function of flux and temperature. For the first time, the influence of laser and electron irradiation on the growth rate, as well as desorption, of CdTe is studied in detail using RHEED oscillations. We found a very small effect on the growth rate as well as on the CdTe desorption rate. The growth rate of CdTe was determined for different temperatures and CdTe flux ratios. The obtained experimental results are compared with a kinetic growth model to get information on the underlying growth processes, taking into account the influence of a precursor by including surface diffusion. From the comparison between model and experimental results the sticking coefficients of Cd and Te are determined. The growth rate of CdMnTe increases with Mn flux. This dependence can be used to calibrate the Mn content during growth by comparing the growth rate of CdTe with the growth rate of CdMnTe. The change in growth rate has been correlated with Mn content via photoluminescence measurements. In addition, the sticking coefficient of Mn is derived by comparing experimental results with a kinetic growth model. For high manganese content a transition to three-dimensional growth occurs. (orig.).

[Does routine outcome monitoring have a promising future? An investigation into the use of shared decision-making combined with ROM for patients with a combination of physical and psychiatric symptoms].

Science.gov (United States)

van der Feltz-Cornelis, C M; Andrea, H; Kessels, E; Duivenvoorden, H J; Biemans, H; Metz, M

2014-01-01

Although routine outcome monitoring (ROM) has been developed and widely used in the course of patient centered outcome research in the Netherlands, so far the technique has hardly ever been used to improve the treatment of individual patients. To describe how a rom technique based on the principles of shared decision-making (SDM) was developed and evaluated at the Center for Body, Mind and Health at GGz Breburg, a specialised mental health institution in the Netherlands. We have developed a conceptual model for SDM that involves patient participation and the use of evidence-based decision-aids with cut-off scores. According to the conceptual model for SDM that we developed, the patient and the health professional involved took 'shared' decisions in three phases; the decisions related to triage, the drawing-up of a treatment plan and a follow-up treatment course. At the end of the 6 month intake-phase 7 of the 67 patients who were deemed eligible for ROM/SDM were dropped from the study because they were incapable of performing ROM assessments. Due to diagnostic advice and referral at the end of the intake-phase, 25 patients did not require further treatment. Of the remaining 35 patients, 33 delivered at least one follow-up ROM assessment during the subsequent treatment phases. In these patients somatic and psychiatric symptoms were found to be significantly reduced. ROM combined with sdm can be used successfully with patients who have a combination of physical and psychiatric symptoms and the technique can be applied by the professional in charge. Very few patients dropped out of the follow-up measurements and somatic as well as depressive or psychiatric symptoms diminished significantly. These findings indicate that a Randomised Clinical Trial is warranted in order to test the effectiveness of sdm combined with ROM as a decision-making instrument.

75 FR 32803 - Notice of Issuance of Final Determination Concerning a GTX Mobile+ Hand Held Computer

Science.gov (United States)

2010-06-09

... shall be published in the Federal Register within 60 days of the date the final determination is issued..., involved various scenarios pertaining to the assembly of a desktop computer in the U.S. and the Netherlands... finished desktop computers depending on the model included an additional floppy drive, CD ROM disk, and...

78 FR 14088 - Creation of a New System of Records Notice: Telework Application and Agreement Records

Science.gov (United States)

2013-03-04

... know your identity or contact information unless you provide it in the body of your comment. If you... include your name and other contact information in the body of your comment and with any disk or CD-ROM... identification card, employee badge or identification card and, if necessary, proof of authority). Additional...

Inventory of Innovative Learning Materials in Marine Science and Technology. UNESCO Reports in Marine Science 60.

Science.gov (United States)

Richards, Adrian F.; Richards, Efrosine A.

The Inventory of Innovative Learning Materials in Marine Science and Technology includes 32 computer-, 148 video-, 16 film-, and 11 CD-ROM-based entries. They concern materials in biosciences (67), chemistry (5), geosciences (16), physics (23), technology (76) and other (20). This first, initial compilations is conceived as the basis for more…

Tailings and mine waste '98

International Nuclear Information System (INIS)

Anon.

1998-01-01

Topics covered include: regulatory; design, operation and disposal; paste technology; geotechnical considerations; liners, covers and barriers; ground water and geochemistry; surface water quality; remediation and reclamation; reprocessing, utilization and treatment; and case histories. Four papers have been abstracted separately for the IEA Coal Research databases available on CD-ROM and the worldwide web

Menetrier's disease accompanied thrombosis of the iiac vein

Energy Technology Data Exchange (ETDEWEB)

Kang, Hyun Il; Lee, Young Joong; Park, Choong Ki; Yoon, Jong Sup; Park, Young E [Hallym University College of Medicine, Chuncheon (Korea, Republic of)

1986-08-15

Menetrier's disease is a rare cause of thickened gastric wall. The differential diagnosis of diffuse gastric wall thickening such as lymphoma and adenocarcinoma should be expanded to include Menetrier's disease. The authors experienced a case of Menetrier's disease accompanied deep vein thrombosis, which was proved by operation and pathology. We carried out double contrast upper G-I series and computed tomography, and report with review of literatures.

Total hip arthroplasty (S-ROM stem and subtrochanteric osteotomy for Crowe type IV developmental dysplasia of the hip

Directory of Open Access Journals (Sweden)

Liangtao Li

2016-01-01

Conclusions: In the primary THA for the treatment of irreducible DDH, subtrochanteric oblique osteotomy combined with the freely-rotatable S-ROM stem provided favorable short term outcomes by affording both morphological and functional advantages.

Test bank to accompany Computers data and processing

CERN Document Server

Deitel, Harvey M

1980-01-01

Test Bank to Accompany Computers and Data Processing provides a variety of questions from which instructors can easily custom tailor exams appropriate for their particular courses. This book contains over 4000 short-answer questions that span the full range of topics for introductory computing course.This book is organized into five parts encompassing 19 chapters. This text provides a very large number of questions so that instructors can produce different exam testing essentially the same topics in succeeding semesters. Three types of questions are included in this book, including multiple ch

CD133 expression is not restricted to stem cells, and both CD133+ and CD133– metastatic colon cancer cells initiate tumors

Science.gov (United States)

Shmelkov, Sergey V.; Butler, Jason M.; Hooper, Andrea T.; Hormigo, Adilia; Kushner, Jared; Milde, Till; St. Clair, Ryan; Baljevic, Muhamed; White, Ian; Jin, David K.; Chadburn, Amy; Murphy, Andrew J.; Valenzuela, David M.; Gale, Nicholas W.; Thurston, Gavin; Yancopoulos, George D.; D’Angelica, Michael; Kemeny, Nancy; Lyden, David; Rafii, Shahin

2008-01-01

Colon cancer stem cells are believed to originate from a rare population of putative CD133+ intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells expresses CD133, and that only these CD133+ cancer cells are capable of tumor initiation. However, the precise contribution of CD133+ tumor-initiating cells in mediating colon cancer metastasis remains unknown. Therefore, to temporally and spatially track the expression of CD133 in adult mice and during tumorigenesis, we generated a knockin lacZ reporter mouse (CD133lacZ/+), in which the expression of lacZ is driven by the endogenous CD133 promoters. Using this model and immunostaining, we discovered that CD133 expression in colon is not restricted to stem cells; on the contrary, CD133 is ubiquitously expressed on differentiated colonic epithelium in both adult mice and humans. Using Il10–/–CD133lacZ mice, in which chronic inflammation in colon leads to adenocarcinomas, we demonstrated that CD133 is expressed on a full gamut of colonic tumor cells, which express epithelial cell adhesion molecule (EpCAM). Similarly, CD133 is widely expressed by human primary colon cancer epithelial cells, whereas the CD133– population is composed mostly of stromal and inflammatory cells. Conversely, CD133 expression does not identify the entire population of epithelial and tumor-initiating cells in human metastatic colon cancer. Indeed, both CD133+ and CD133– metastatic tumor subpopulations formed colonospheres in in vitro cultures and were capable of long-term tumorigenesis in a NOD/SCID serial xenotransplantation model. Moreover, metastatic CD133– cells form more aggressive tumors and express typical phenotypic markers of cancer-initiating cells, including CD44 (CD44+CD24–), whereas the CD133+ fraction is composed of CD44lowCD24+ cells. Collectively, our data suggest that CD133 expression is not restricted to intestinal stem or cancer-initiating cells, and during the metastatic

RCRA and operational monitoring (ROM): Multi-year program plan and fiscal year 96 work plan. WBS 1.5.3, Revision 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

The RCRA & Operational Monitoring (ROM) Program Office manages the Hanford Site direct funded Resource Conservation and Recovery Act (RCRA) and Operational Monitoring under Work Breakdown Structure (WBS) 1.01.05.03. The ROM Program Office is included in Hanford Technical Services, a part of Projects & Site Services of Westinghouse Hanford Company (WHC). The 1996 Multi-Year Program Plan (MYPP) includes the Fiscal Year Work Plan (FYWP). The Multi-Year Program Plan takes its direction from the Westinghouse Planning Baseline Integration Organization. The MYPP provides both the near term, enhanced details and the long term, projected details for the Program Office to use as baseline Cost, Scope and Schedule. Change Control administered during the fiscal year is against the baseline provided by near term details of this document. The MYPP process has been developed by WHC to meet its internal planning and integration needs and complies with the requirements of the US Department of Energy, Richland Operations Office (RL) Long Range Planning Process Directive (RLID 5000.2). Westinghouse Hanford Company (WHC) has developed the multi-year planning process for programs to establish the technical, schedule and cost baselines for program and support activities under WHC`s scope of responsibility. The baseline information is developed by both WHC indirect funded support services organization, and direct funded programs in WHC. WHC Planning and Integration utilizes the information presented in the program specific MYPP and the Program Master Baseline Schedule (PMBS) to develop the Site-Wide Integrated Schedule.

RCRA and operational monitoring (ROM): Multi-year program plan and fiscal year 96 work plan. WBS 1.5.3, Revision 1

International Nuclear Information System (INIS)

1995-09-01

The RCRA ampersand Operational Monitoring (ROM) Program Office manages the Hanford Site direct funded Resource Conservation and Recovery Act (RCRA) and Operational Monitoring under Work Breakdown Structure (WBS) 1.01.05.03. The ROM Program Office is included in Hanford Technical Services, a part of Projects ampersand Site Services of Westinghouse Hanford Company (WHC). The 1996 Multi-Year Program Plan (MYPP) includes the Fiscal Year Work Plan (FYWP). The Multi-Year Program Plan takes its direction from the Westinghouse Planning Baseline Integration Organization. The MYPP provides both the near term, enhanced details and the long term, projected details for the Program Office to use as baseline Cost, Scope and Schedule. Change Control administered during the fiscal year is against the baseline provided by near term details of this document. The MYPP process has been developed by WHC to meet its internal planning and integration needs and complies with the requirements of the US Department of Energy, Richland Operations Office (RL) Long Range Planning Process Directive (RLID 5000.2). Westinghouse Hanford Company (WHC) has developed the multi-year planning process for programs to establish the technical, schedule and cost baselines for program and support activities under WHC's scope of responsibility. The baseline information is developed by both WHC indirect funded support services organization, and direct funded programs in WHC. WHC Planning and Integration utilizes the information presented in the program specific MYPP and the Program Master Baseline Schedule (PMBS) to develop the Site-Wide Integrated Schedule

Supplemental materials for the ICDP-USGS Eyreville A, B, and C core holes, Chesapeake Bay impact structure: Core-box photographs, coring-run tables, and depth-conversion files

Science.gov (United States)

Durand, C.T.; Edwards, L.E.; Malinconico, M.L.; Powars, D.S.

2009-01-01

During 2005-2006, the International Continental Scientific Drilling Program and the U.S. Geological Survey drilled three continuous core holes into the Chesapeake Bay impact structure to a total depth of 1766.3 m. A collection of supplemental materials that presents a record of the core recovery and measurement data for the Eyreville cores is available on CD-ROM at the end of this volume and in the GSA Data Repository. The supplemental materials on the CD-ROM include digital photographs of each core box from the three core holes, tables of the three coring-run logs, as recorded on site, and a set of depth-conversion programs. In this chapter, the contents, purposes, and basic applications of the supplemental materials are briefly described. With this information, users can quickly decide if the materials will apply to their specific research needs. ?? 2009 The Geological Society of America.

Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism.

Directory of Open Access Journals (Sweden)

Gürkan Kaya

2006-12-01

Full Text Available BACKGROUND: Skin atrophy is a common manifestation of aging and is frequently accompanied by ulceration and delayed wound healing. With an increasingly aging patient population, management of skin atrophy is becoming a major challenge in the clinic, particularly in light of the fact that there are no effective therapeutic options at present. METHODS AND FINDINGS: Atrophic skin displays a decreased hyaluronate (HA content and expression of the major cell-surface hyaluronate receptor, CD44. In an effort to develop a therapeutic strategy for skin atrophy, we addressed the effect of topical administration of defined-size HA fragments (HAF on skin trophicity. Treatment of primary keratinocyte cultures with intermediate-size HAF (HAFi; 50,000-400,000 Da but not with small-size HAF (HAFs; 400,000 Da induced wild-type (wt but not CD44-deficient (CD44-/- keratinocyte proliferation. Topical application of HAFi caused marked epidermal hyperplasia in wt but not in CD44-/- mice, and significant skin thickening in patients with age- or corticosteroid-related skin atrophy. The effect of HAFi on keratinocyte proliferation was abrogated by antibodies against heparin-binding epidermal growth factor (HB-EGF and its receptor, erbB1, which form a complex with a particular isoform of CD44 (CD44v3, and by tissue inhibitor of metalloproteinase-3 (TIMP-3. CONCLUSIONS: Our observations provide a novel CD44-dependent mechanism for HA oligosaccharide-induced keratinocyte proliferation and suggest that topical HAFi application may provide an attractive therapeutic option in human skin atrophy.

Reprocessing of multi-channel seismic-reflection data collected in the Chukchi Sea

Science.gov (United States)

Agena, W.F.; Lee, M.W.; Hart, P.E.

2001-01-01

Contained on this set of two CD-ROMs are stacked and migrated multi-channel seismic-reflection data for 44 lines recorded in the Chukchi Sea, northern Alaska, by the United States Geological Survey in 1977, 1978, and 1980. All data were reprocessed by the USGS in 2000 using updated methods. The resulting final data have both increased temporal and spatial resolution thus providing improved interpretability. An added benefit of these CD-ROMs is that they are a more stable, long-term archival medium for the data.

Determination of normal expression patterns of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood and bone marrow cells by flow cytometry.

Science.gov (United States)

Rudolf-Oliveira, Renata Cristina Messores; Auat, Mariangeles; Cardoso, Chandra Chiappin; Santos-Pirath, Iris Mattos; Lange, Barbara Gil; Pires-Silva, Jéssica; Moraes, Ana Carolina Rabello de; Dametto, Gisele Cristina; Pirolli, Mayara Marin; Colombo, Maria Daniela Holthausen Périco; Santos-Silva, Maria Claudia

2018-02-01

In 2010, new monoclonal antibodies were submitted to the 9th International Workshop on Human Leukocyte Differentiation Antigens, and there are few studies demonstrating normal expression patterns of these markers. Thus, the objective of this study was to determine the normal patterns of cell expression of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood (PB) and bone marrow (BM) samples by flow cytometry. In the present study, CD86 was expressed only in monocytes and B lymphocytes in PB and in monocytes and plasma cells in BM. Regarding CD210a expression, in PB samples, monocytes and NK cells showed weak expression, while neutrophils, B and T lymphocytes, and basophils showed weak and partial expression. In BM samples, expression of CD210a was observed in eosinophils, monocytes, and B and T/NK lymphocytes. Weak expression of CD210a was also observed in neutrophilic cells and plasma cells. All B cell maturation stages had weak expression of CD210a except for immature B cells, which did not express this marker. In the present study, no cell type in PB samples showed positivity for CD261 and, in BM samples, there was very weak expression in neutrophilic series, monocytes, and B lymphocytes. Conversely, plasma cells showed positivity for CD261 with a homogeneous expression. For CD262, there was weak expression in monocytes, neutrophils, and B lymphocytes in PB samples and weak expression in monocytes, B lymphocytes, and plasma cells in BM samples. The evaluation of CD264 showed very weak expression in B cells in PB samples and no expression in BM cells. Very weak expression of CD358 was observed in neutrophils, monocytes, and B lymphocytes in PB and BM samples. In addition, in BM samples, plasma cells and T lymphocytes showed weak expression of CD358. In relation to the maturation stages of B cells, there was weak expression in pro-B cel, pre-B cell, and mature B cell. In the present study, it was possible to observe expression of CD361 in all

A Comprehensive Guide to Music Therapy

DEFF Research Database (Denmark)

Wigram, Anthony Lewis; Pedersen, Inge Nygaard; Bonde, Lars Ole

A detailed guide to music therapy from an international perspective, covering theory, practice, assessment, research and training. 2nd Edition of the first Danish Handbook in music theory, clinical practice, research and training. The Danish version "Musikterapi: Når ord ikke slår til......" was published in 2001 by KLIM, Aarhus DK. The English Edition has a more international orientation and a broader view on research and extended bibliography. The book includes a music CD and a CD rom....

Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response

Science.gov (United States)

Roberts, Lydia M; Ledvina, Hannah E; Tuladhar, Shraddha; Rana, Deepa; Steele, Shaun P; Sempowski, Gregory D; Frelinger, Jeffrey A

2015-01-01

Alveolar macrophages play a critical role in initiating the immune response to inhaled pathogens and have been shown to be the first cell type infected following intranasal inoculation with several pathogens, including Francisella tularensis. In an attempt to further dissect the role of alveolar macrophages in the immune response to Francisella, we selectively depleted alveolar macrophages using CD11c.DOG mice. CD11c.DOG mice express the diphtheria toxin receptor (DTR) under control of the full CD11c promoter. Because mice do not express DTR, tissue restricted expression of the primate DTR followed by treatment with diphtheria toxin (DT) has been widely used as a tool in immunology to examine the effect of acute depletion of a specific immune subset following normal development. We successfully depleted alveolar macrophages via intranasal administration of DT. However, alveolar macrophage depletion was accompanied by many other changes to the cellular composition and cytokine/chemokine milieu in the lung that potentially impact innate and adaptive immune responses. Importantly, we observed a transient influx of neutrophils in the lung and spleen. Our experience serves as a cautionary note to other researchers using DTR mice given the complex changes that occur following DT treatment that must be taken into account when analyzing data. PMID:26029367

High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice.

Science.gov (United States)

Gao, Mingming; Ma, Yongjie; Liu, Dexi

2015-01-01

High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity and obesity related metabolic complications. In this study, we determined HFD induced development of metabolic disorders on outbred female CD-1 mice in a time dependent manner. Compared to mice on regular chow, HFD-fed CD-1 mice gradually gained more fat mass and consequently exhibited accelerated body weight gain, which was associated with adipocyte hypertrophy and up-regulated expression of adipose inflammatory chemokines and cytokines such as Mcp-1 and Tnf-α. Increased fat accumulation in white adipose tissue subsequently led to ectopic fat deposition in brown adipose tissue, giving rise to whitening of brown adipose tissue without altering plasma level of triglyceride. Ectopic fat deposition was also observed in the liver, which was associated with elevated expression of key genes involved in hepatic lipid sequestration, including Ppar-γ2, Cd36 and Mgat1. Notably, adipose chronic inflammation and ectopic lipid deposition in the liver and brown fat were accompanied by glucose intolerance and insulin resistance, which was correlated with hyperinsulinemia and pancreatic islet hypertrophy. Collectively, these results demonstrate sequentially the events that HFD induces physiological changes leading to metabolic disorders in an outbred mouse model more closely resembling heterogeneity of the human population.

49 CFR 591.6 - Documents accompanying declarations.

Science.gov (United States)

2010-10-01

... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) IMPORTATION OF VEHICLES AND EQUIPMENT SUBJECT TO FEDERAL SAFETY, BUMPER AND THEFT PREVENTION STANDARDS § 591.6 Documents accompanying... be accompanied by a statement substantiating that the vehicle was not manufactured for use on the...

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells.

Directory of Open Access Journals (Sweden)

Leslie R Cockerham

Full Text Available The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1 in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.

Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions

DEFF Research Database (Denmark)

Ishøy, Mette; Petersen, Rico; Petersen, Michael Åxman

2017-01-01

A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenableto subsequent functionalization and library synthesis...

76 FR 22882 - Draft National Pollutant Discharge Elimination System (NPDES) General Permit for Stormwater...

Science.gov (United States)

2011-04-25

... know your identity or contact information unless you provide it in the body of your comment. If you... include your name and other contact information in the body of your comment and with any disk or CD-ROM... visually assess the quality of the discharge (e.g., color, odor, floating, settled, or suspended solids) if...

76 FR 16365 - Approval and Promulgation of Implementation Plans; Washington: Correction

Science.gov (United States)

2011-03-23

... know your identity or contact information unless you provide it in the body of your comment. If you... include your name and other contact information in the body of your comment and with any disk or CD-ROM... relating to hazardous air pollutants); 73 FR 21546 (April 22, 2008) (removing the word ``odor'' from the...

CD44 deficiency enhanced Streptococcus equi ssp. zooepidemicus dissemination and inflammation response in a mouse model.

Science.gov (United States)

Fu, Qiang; Xiao, Pingping; Chen, Yaosheng; Wei, Zigong; Liu, Xiaohong

2017-12-01

Streptococcus equi ssp. zooepidemicus (S. zooepidemicus) is responsible for peritonitis, septicemia, meningitis, arthritis and several other serious diseases in various species. Recent studies have demonstrated that CD44 is implicated in the process of host defense against pathogenic microorganisms. In the present study, the role of CD44 in the host response to S. zooepidemicus infection was investigated in a mouse model. Upon intraperitoneal infection with S. zooepidemicus, the expression of CD44 on the peritoneal exudate cells from wild-type (WT) mice was increased. CD44 deficiency accelerated mortality, which was accompanied by increased peritoneal bacterial growth and dissemination to distant body sites. CD44 knock-out (KO) mice showed enhanced early inflammatory cell recruitment into the peritoneal fluid on S. zooepidemicus infection. In line with this, the expression of proinflammatory cytokines, chemokines in peritoneal exudate cells and peritoneal macrophages of CD44 KO mice were increased compared with those of WT mice. In addition, CD44 deficiency was associated with reduced expression of A20, a negative regulator in TLR signaling. Overall, the present study suggests that CD44 plays a protective role in antibacterial defense against S. zooepidemicus in mice. Copyright © 2017. Published by Elsevier Ltd.

Using a Multimedia Tool to Improve Cardiac Auscultation Knowledge and Skills

Science.gov (United States)

Stern, David T; Mangrulkar, Rajesh S; Gruppen, Larry D; Lang, Angela L; Grum, Cyril M; Judge, Richard D

2001-01-01

OBJECTIVE Today's medical school graduates have significant deficits in physical examination skills. Medical educators have been searching for methods to effectively teach and maintain these skills in students. The objective of this study was to determine if an auscultation curriculum centered on a portable multimedia CD-ROM was effective in producing and maintaining significant gains in cardiac auscultatory skills. DESIGN Controlled cohort study PARTICIPANTS All 168 third-year medical students at 1 medical school in an academic medical center. INTERVENTIONS Students were tested before and after exposure to 1 or more elements of the auscultation curriculum: teaching on ward/clinic rotations, CD-ROM comprehensive cases with follow-up seminars, and a CD-ROM 20-case miniseries. The primary outcome measures were student performance on a 10-item test of auscultation skill (listening and identifying heart sound characteristics) and a 30-item test of auscultation knowledge (factual questions about auscultation). A subset of students was tested for attenuation effects 9 or 12 months after the intervention. RESULTS Compared with the control group (1 month clinical rotation alone), students who were also exposed to the CD-ROM 20-case miniseries had significant improvements in auscultation skills scores (P auscultation knowledge beyond the miniseries alone (P auscultation skills. Students' auscultation knowledge diminished one year after the intervention, but auscultation skills did not. CONCLUSION In addition to the standard curriculum of ward and conference teaching, portable multimedia tools may help improve quality of physical examination skills. PMID:11722691

Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?

Directory of Open Access Journals (Sweden)

Peter John Lane

2012-02-01

Full Text Available Phylogeny suggests that the evolution of placentation in mammals was accompanied by substantial changes in the mammalian immune system: in particular lymph nodes and CD4 high affinity memory antibody responses co-evolved during the same period. Lymphoid tissue inducer cells (LTi are members of an emerging family of innate lymphoid cells (ILCs that are crucial for lymph node development, but our studies have indicated that they also play a pivotal role in the long-term maintenance of memory CD4 T cells in adult mammals through their expression of the tumor necrosis family members, OX40- and CD30-ligands. Additionally, our studies have shown that these two molecules are also key operators in CD4 effector function, as their absence obviates the need for the FoxP3-dependent regulatory T cells (Tregs that prevent CD4 driven autoimmune responses. In this perspective article, we summarize findings from our group over the last 10 years, and focus specifically on the role of LTi in thymus. We suggest that like memory CD4 T cells, LTi also play a role in the selection and maintenance of the Tregs that under normal circumstances are absolutely required to regulate CD4 effector cells.

Effect of Ankle Range of Motion (ROM) and Lower-Extremity Muscle Strength on Static Balance Control Ability in Young Adults: A Regression Analysis.

Science.gov (United States)

Kim, Seong-Gil; Kim, Wan-Soo

2018-05-15

BACKGROUND The purpose of this study was to investigate the effect of ankle ROM and lower-extremity muscle strength on static balance control ability in young adults. MATERIAL AND METHODS This study was conducted with 65 young adults, but 10 young adults dropped out during the measurement, so 55 young adults (male: 19, female: 36) completed the study. Postural sway (length and velocity) was measured with eyes open and closed, and ankle ROM (AROM and PROM of dorsiflexion and plantarflexion) and lower-extremity muscle strength (flexor and extensor of hip, knee, and ankle joint) were measured. Pearson correlation coefficient was used to examine the correlation between variables and static balance ability. Simple linear regression analysis and multiple linear regression analysis were used to examine the effect of variables on static balance ability. RESULTS In correlation analysis, plantarflexion ROM (AROM and PROM) and lower-extremity muscle strength (except hip extensor) were significantly correlated with postural sway (psimple correlation analysis, all variables that passed the correlation analysis procedure had significant influence (plinear regression analysis, plantar flexion PROM with eyes open significantly influenced sway length (B=0.681) and sway velocity (B=0.011). CONCLUSIONS Lower-extremity muscle strength and ankle plantarflexion ROM influenced static balance control ability, with ankle plantarflexion PROM showing the greatest influence. Therefore, both contractile structures and non-contractile structures should be of interest when considering static balance control ability improvement.

Properties of mouse CD40: differential expression of CD40 epitopes on dendritic cells and epithelial cells

NARCIS (Netherlands)

van den Berg, T. K.; Hasbold, J.; Renardel de Lavalette, C.; Döpp, E. A.; Dijkstra, C. D.; Klaus, G. G.

1996-01-01

In this study we describe the tissue distribution of mouse CD40 using two monoclonal antibodies (mAb) against different epitopes of the molecule. In lymphoid tissues CD40 was expressed by B lymphocytes. Most B cells in typical B-cell compartments were CD40-positive, including germinal centre B

CD4+/CD8+ double-positive T cells

DEFF Research Database (Denmark)

Overgaard, Nana H; Jung, Ji-Won; Steptoe, Raymond J

2015-01-01

CD4(+)/CD8(+) DP thymocytes are a well-described T cell developmental stage within the thymus. However, once differentiated, the CD4(+) lineage or the CD8(+) lineage is generally considered to be fixed. Nevertheless, mature CD4(+)/CD8(+) DP T cells have been described in the blood and peripheral...... cells, CD4(+)/CD8(+) T cell populations, outside of the thymus, have recently been described to express concurrently ThPOK and Runx3. Considerable heterogeneity exists within the CD4(+)/CD8(+) DP T cell pool, and the function of CD4(+)/CD8(+) T cell populations remains controversial, with conflicting...... reports describing cytotoxic or suppressive roles for these cells. In this review, we describe how transcriptional regulation, lineage of origin, heterogeneity of CD4 and CD8 expression, age, species, and specific disease settings influence the functionality of this rarely studied T cell population....

Alloy formation during the electrochemical growth of a Ag-Cd ultrathin film on Au(1 1 1)

International Nuclear Information System (INIS)

Barrio, M.C. del; Garcia, S.G.; Salinas, D.R.

2009-01-01

The electrodeposition of a Ag/Cd ultrathin film on a Au(1 1 1) surface and the formation of a surface alloy during this process have been studied using classical electrochemical techniques and in situ Scanning Tunneling Microscopy (STM). The films were obtained from separate electrolytes containing Ag + or Cd 2+ ions and from a multicomponent solution containing both ions. First, the polarization conditions were adjusted in order to form a Ag film by overpotential deposition. Afterwards, a Cd monolayer was formed onto this Au(1 1 1)/Ag modified surface by underpotential deposition. The voltammetric behavior of the Cd UPD and the in situ STM images indicated that the ultrathin Ag films were uniformly deposited and epitaxially oriented with respect to the Au(1 1 1) surface. Long time polarization experiments showed that a significant Ag-Cd surface alloying accompanied the formation of the Cd monolayer on the Au(1 1 1)/Ag modified surface, independent of the Ag film thickness. In the case of an extremely thin Ag layer (1 Ag ML) the STM images and long time polarization experiments revealed a solid state diffusion process of Cd, Ag, and Au atoms which can be responsible for the formation of different Ag-Cd or Au-Ag-Cd alloy phases.

Manual on restoration strategies for radioactive-contaminated sites. RESTRAT-TD 14

International Nuclear Information System (INIS)

Zeevaert, T.; Brendler, V.; Nordlinder, S.; Hedemann Jensen, P.; Bousher, A.

1999-06-01

This report is submitted as Technical Deliverable No. 14 against the requirements of the RESTRAT (Restoration Strategies for radioactively contaminated Sites and their Close Surroundings) Project. In this manual the methodology for ranking restoration options is explained and applied to example sites that are representative for major categories of contaminated sites. Potentially relevant techniques for restoration of contaminated sites are identified and characterised and the data collected included on a CD-ROM. For the ranking of the restoration options, a multi-attribute utility (MAU) type of analysis has been chosen with a view to the various categories of attributes that are being taken into account: radiological health detriment; economic costs; social factors. The methods of assessing the attributes and converting the attribute values into utility values for the scoring of the options are explained. The models applied for assessing the collective dose to the population and for the ranking of the remediation options (MAU analysis) are explained and the software included on two CD-ROMs added to the manual

Annual seminar on electronic sources of information

International Nuclear Information System (INIS)

Ravichandra Rao, I.K.

2000-03-01

With the rapid development in IT and the emergence of Internet, a multitude of information sources are now available on electronic media. They include e-journals and other electronic publications - online databases, reference documents, newspapers, magazines, etc. In addition to these online sources, there are thousands of CD-ROM databases. The CD-ROM databases and the online sources are collectively referred to as electronic sources of information. Libraries in no part of the world can afford to ignore these sources. Emergence of these new sources has resulted into a change in the traditional library functions including collection development, acquisitions, cataloguing, user instructions, etc. It is inevitable that in the next five to ten years, special libraries may have to allocate considerable amount towards subscription of e-journals and other e-publications. The papers in this seminar volume discuss several aspects related the theme of the seminar and cover e-journals, different sources available in the Net, classification of electronic sources, online public access catalogues, and different aspects of Internet. Papers relevant to INIS are indexed separately

Manual on restoration strategies for radioactive-contaminated sites. RESTRAT-TD 14

Energy Technology Data Exchange (ETDEWEB)

Zeevaert, T.; Brendler, V.; Nordlinder, S.; Hedemann Jensen, P.; Bousher, A

1999-06-01

This report is submitted as Technical Deliverable No. 14 against the requirements of the RESTRAT (Restoration Strategies for radioactively contaminated Sites and their Close Surroundings) Project. In this manual the methodology for ranking restoration options is explained and applied to example sites that are representative for major categories of contaminated sites. Potentially relevant techniques for restoration of contaminated sites are identified and characterised and the data collected included on a CD-ROM. For the ranking of the restoration options, a multi-attribute utility (MAU) type of analysis has been chosen with a view to the various categories of attributes that are being taken into account: radiological health detriment; economic costs; social factors. The methods of assessing the attributes and converting the attribute values into utility values for the scoring of the options are explained. The models applied for assessing the collective dose to the population and for the ranking of the remediation options (MAU analysis) are explained and the software included on two CD-ROMs added to the manual.

CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells.

Science.gov (United States)

Ateba-Ngoa, Ulysse; Mombo-Ngoma, Ghyslain; Zettlmeissl, Eva; van der Vlugt, Luciën E P M; de Jong, Sanne E; de Jong, Sanne; Matsiegui, Pierre-Blaise; Ramharter, Michael; Kremsner, Peter G; Yazdanbakhsh, Maria; Adegnika, Ayola Akim

2014-01-01

Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers. Moreover children from filaria infected mothers have been shown to be less responsive to vaccination as a consequence of an impairment of their immune response. However, it is not well known how in utero exposure to parasite antigens affects cellular immune responses. Here, 30 pregnant women were examined for the presence of microfilaria of Loa loa and Mansonella perstans in peripheral blood. At delivery, cord blood mononuclear cells (CBMC) were obtained and the CD4+T cells were phenotyped by expression of the transcription factors Tbet, RORγt, and FOXP3. No significant difference was observed between newborns from infected versus uninfected mothers in the frequencies of total CD4+T cells and CD4+T cells subsets including CD4+Tbet+, CD4+RORγt+ T and CD4+CD25hiFOXP3+ T cells. However, there was a negative association between CD4+CD25hiFOXP3+T cells and CD4+Tbet+ as well as CD4+RORγt+ T cells in the infected group only (B = -0.242, P = 0.002; B = -0.178, P = 0.013 respectively). Our results suggest that filarial infection during pregnancy leads to an expansion of functionally active regulatory T cells that keep TH1 and TH17 in check.

CD1d-dependent NKT cells play a protective role in acute and chronic arthritis models by ameliorating antigen-specific Th1 responses

DEFF Research Database (Denmark)

Teige, Anna; Bockermann, Robert; Hasan, Maruf

2010-01-01

-induced arthritis (AIA) and collagen-induced arthritis (CIA), to evaluate acute and chronic arthritis in CD1d knockout mice and mice depleted of NK1.1(+) cells. CD1d-deficient mice developed more severe AIA compared with wild-type littermates, with a higher degree of inflammation and proteoglycan depletion. Chronic...... arthritis in CIA was also worse in the absence of CD1d-dependent NKTs. Elevated levels of Ag-specific IFN-gamma production accompanied these findings rather than changes in IL-17alpha. Depletion of NK1.1(+) cells supported these findings in AIA and CIA. This report provides support for CD1d-dependent NKTs...

Prospectus 2000

Science.gov (United States)

Holmes, Jon L.; Gettys, Nancy S.

2000-01-01

We begin 2000 with a message about our plans for JCE Software and what you will be seeing in this column as the year progresses. Floppy Disk --> CD-ROM Most software today is distributed on CD-ROM or by downloading from the Internet. Several new computers no longer include a floppy disk drive as "standard equipment". Today's software no longer fits on one or two floppies (the installation software alone can require two disks) and the cost of reproducing and distributing several disks is prohibitive. In short, distribution of software on floppy disks is no longer practical. Therefore, JCE Software will distribute all new software publications on CD-ROM rather than on disks. Regular Issues --> Collections Distribution of all our software on CD-ROM allows us to extend our concept of software collections that we started with the General Chemistry Collection. Such collections will contain all the previously published software that is still "in print" (i.e., is compatible with current operating systems and hardware) and any new programs that fall under the topic of the collection. Proposed topics in addition to General Chemistry currently include Advanced Chemistry, Instrument and Laboratory Simulations, and Spectroscopy. Eventually, all regular issues will be replaced by these collections, which will be updated annually or semiannually with new programs and updates to existing programs. Abstracts for all new programs will continue to appear in this column when a collection or its update is ready for publication. We will continue to offer special issues of single larger programs (e.g. Periodic Table Live!, Chemistry Comes Alive! volumes) on CD-ROM and video on videotape. Connect with Your Students outside Class JCE Software has always offered network licenses to allow instructors to make our software available to students in computer labs, but that model no longer fits the way many instructors and students work with computers. Many students (or their families) own a

Role of CD81 and CD58 in minimal residual disease detection in pediatric B lymphoblastic leukemia.

Science.gov (United States)

Tsitsikov, E; Harris, M H; Silverman, L B; Sallan, S E; Weinberg, O K

2018-06-01

Minimal residual disease (MRD) in B lymphoblastic leukemia has been demonstrated to be a powerful predictor of clinical outcome in numerous studies in both children and adults. In this study, we evaluated 86 pediatric patients with both diagnostic and remission flow cytometry studies and compared expression of CD81, CD58, CD19, CD34, CD20, and CD38 in the detection of MRD. We evaluated 86 patients with B lymphoblastic leukemia who had both diagnostic studies and remission studies for the presence of MRD using multicolor flow cytometry. We established our detection limit for identifying abnormal lymphoblasts using serial dilutions. We also compared flow cytometry findings with molecular MRD detection in a subset of patients. We found that we can resolve differences between hematogones and lymphoblasts in 85 of 86 cases using a combination of CD45, CD19, CD34, CD10, CD20, CD38, CD58, and CD81. Our detection limit using flow cytometry is 0.002% for detecting a population of abnormal B lymphoblasts. Comparison with MRD assessment by molecular methods showed a high concordance rate with flow cytometry findings. Our study highlights importance of using multiple markers to detect MRD in B lymphoblastic leukemia. Our findings indicate that including both CD58 and CD81 markers in addition to CD19, CD34, CD20, CD38, and CD10 are helpful in MRD detection by flow cytometry. © 2018 John Wiley & Sons Ltd.

Magnetismo 2000

Science.gov (United States)

Cardús, J. O.; Curto, J. J.; Sanclement, E.; Torta, J. M.

This CD-ROM presents the digital version of the Boletin del Observatorio del Ebro Magnetismo. It contains data obtained in the Magnetic Station of the Ebre Observatory during the year 2000. The structure of the CD-ROM consists of one directory numbered with the year of the measurement. There, it could be found the bulletin as printable sheets (Year.pdf) generate with Adobe Acrobat and data files in plain ASCII text (Year.wdc) readable with any text editor. These data files were compiled according to the data exchange format recommended by the IAGA-2002.

Magnetismo 2002

Science.gov (United States)

Cardús, J. O.; Curto, J. J.; Sanclement, E.; Torta, J. M.

This CD-ROM presents the digital version of the Boletin del Observatorio del Ebro Magnetismo. It contains data obtained in the Magnetic Station of the Ebre Observatory during the year 2002. The structure of the CD-ROM consists of one directory numbered with the year of the measurement. There, it could be found the bulletin as printable sheets (Year.pdf) generate with Adobe Acrobat and data files in plain ASCII text (Year.wdc) readable with any text editor. These data files were compiled according to the data exchange format recommended by the IAGA-2002.

Magnetismo 2003

Science.gov (United States)

Cardús, J. O.; Curto, J. J.; Sanclement, E.; Torta, J. M.

This CD-ROM presents the digital version of the Boletin del Observatorio del Ebro Magnetismo. It contains data obtained in the Magnetic Station of the Ebre Observatory during the year 2003. The structure of the CD-ROM consists of one directory numbered with the year of the measurement. There, it could be found the bulletin as printable sheets (Year.pdf) generate with Adobe Acrobat and data files in plain ASCII text (Year.wdc) readable with any text editor. These data files were compiled according to the data exchange format recommended by the IAGA-2002.

Magnetismo 2001

Science.gov (United States)

Cardús, J. O.; Curto, J. J.; Sanclement, E.; Torta, J. M.

This CD-ROM presents the digital version of the Boletin del Observatorio del Ebro Magnetismo. It contains data obtained in the Magnetic Station of the Ebre Observatory during the year 2001. The structure of the CD-ROM consists of one directory numbered with the year of the measurement. There, it could be found the bulletin as printable sheets (Year.pdf) generate with Adobe Acrobat and data files in plain ASCII text (Year.wdc) readable with any text editor. These data files were compiled according to the data exchange format recommended by the IAGA-2002.

A key requirement for CD300f in innate immune responses of eosinophils in colitis.

Science.gov (United States)

Moshkovits, I; Reichman, H; Karo-Atar, D; Rozenberg, P; Zigmond, E; Haberman, Y; Ben Baruch-Morgenstern, N; Lampinen, M; Carlson, M; Itan, M; Denson, L A; Varol, C; Munitz, A

2017-01-01

Eosinophils are traditionally studied in the context of type 2 immune responses. However, recent studies highlight key innate immune functions for eosinophils especially in colonic inflammation. Surprisingly, molecular pathways regulating innate immune activities of eosinophil are largely unknown. We have recently shown that the CD300f is highly expressed by colonic eosinophils. Nonetheless, the role of CD300f in governing innate immune eosinophil activities is ill-defined. RNA sequencing of 162 pediatric Crohn's disease patients revealed upregulation of multiple Cd300 family members, which correlated with the presence of severe ulcerations and inflammation. Increased expression of CD300 family receptors was also observed in active ulcerative colitis (UC) and in mice following induction of experimental colitis. Specifically, the expression of CD300f was dynamically regulated in monocytes and eosinophils. Dextran sodium sulfate (DSS)-treated Cd300f -/- mice exhibit attenuated disease activity and histopathology in comparison with DSS-treated wild type (WT). Decreased disease activity in Cd300f -/- mice was accompanied with reduced inflammatory cell infiltration and nearly abolished production of pro-inflammatory cytokines. Monocyte depletion and chimeric bone marrow transfer experiments revealed a cell-specific requirement for CD300f in innate immune activation of eosinophils. Collectively, we uncover a new pathway regulating innate immune activities of eosinophils, a finding with significant implications in eosinophil-associated gastrointestinal diseases.

Proceedings of the CERI 2005 Oil Conference : What's next? CD-ROM ed.

International Nuclear Information System (INIS)

2005-01-01

Recent developments in the international petroleum industry were discussed, including events unfolding in the world such as rising oil prices, world oil demand and booming oil markets. The changes reflect both fundamental and geopolitical issues such as OPEC's potential productive capacity. The presentations addressed whether these developments in the petroleum industry represent a structural shift in the market or if they are merely another cyclical movement. In addition to the outlook for world energy markets and prospects for oil supply and reserves, this conference included discussions about oil price differentials, markets for Canadian oil, geopolitical hotspots for exporting countries, enhanced recovery for conventional resources and an oil sands outlook. The role that non-conventional oil play will play in the current marketplace was also addressed. The conference featured 18 presentations, of which 6 have been indexed separately for inclusion in this database. tabs., figs

9 CFR 93.409 - Articles accompanying ruminants.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Articles accompanying ruminants. 93.409 Section 93.409 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT...; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Ruminants § 93.409 Articles accompanying ruminants...

RGDS-conjugated CdSeTe/CdS quantum dots as near-infrared fluorescent probe: preparation, characterization and bioapplication

Energy Technology Data Exchange (ETDEWEB)