WorldWideScience

Sample records for accidents graves dans

  1. Pendant la visite de M. Krasucki Grave accident du travail dans le tunnel du LEP

    CERN Multimedia

    Ration, Jean

    1985-01-01

    In the LEP tunnel, where M. Krasucki came some hours before, an accident occured and a worker was seriously injuried, but its days do not seem in danger (together with another article about the visit of M. Krasucki)

  2. R and D relative to the serious accidents in the PWR type reactors: assessment and perspectives; R and D relative aux accidents graves dans les reacteurs a eau pressurisee: bilan et perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Bentaib, A.; Bonneville, H.; Caroli, H.; Chaumont, B.; Clement, B.; Cranga, M.; Koundy, V.; Laurent, B.; Micaelli, J.C.; Meignen, R.; Pichereau, F.; Plassart, D.; Van-Dorsselaere, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Clamart (France); Ducros, G.; Journeau, Ch.; Magallon, D. [CEA Cadarache, 13 - Saint Paul lez Durance (France); Durin, M.; Studer, E. [CEA Saclay 91 - Gif sur Yvette (France); Seiler, J.M. [CEA Grenoble, 38 (France); Ranval, W. [Electricite de France (EDF), 75 - Paris (France)

    2006-07-01

    This document presents the current state of the research relative to the grave accidents realized in France and abroad. It aims at giving the most exhaustive possible and objective vision of this original field of research. He allows to contribute to the identification and to the hierarchical organization of the needs of R and D, this hierarchical organization in front of, naturally, to be completed by a strong lighting on needs in terms of safety analyses associated with the different risks and the physical phenomena, in particular with the support of probability evaluations of safety level 2, whose the level of sharpness must be sufficient not to hide, by construction, physical phenomena of which the limited knowledge leads to important uncertainties. Let us note that neither the safety analyses, nor the E.P.S. 2 are presented in this document. This report presents the physical phenomena which can arise during a grave accident, in the reactor vessel and in the reactor containment, their chain and the means allowing to ease the effects. The corresponding scenarios are presented to the chapter 2. The chapter 3 is dedicated to the progress of the accident in the reactor vessel; the degradation of the core in reactor vessel (3.1), the behavior of the corium in bottom of reactor vessel (3.2) the break of the reactor vessel (3.3) and the fusion in pressure (3.4) are thus handled there. The chapter 4 concerns the phenomena which can lead to a premature failure of the containment, namely the direct heating of gases of the containment (4.1), the hydrogen risk (4.2) and the vapor explosion (4.3). The phenomenon which can lead to a delayed failure from the containment, namely the interaction corium-concrete, is approached on the chapter 5. The chapter 6 is dedicated to the problems connected to the keeping back and to the corium cooling in reactor vessel and out of reactor vessel, namely the keeping back in reactor vessel by re-flooding of the primary circuit or by re

  3. Neutronics aspects associated to the prevention and mitigation of severe accidents in sodium cooled reactor cores; Aspects de neutronique associes a la prevention et a la reduction des accidents graves dans les coeurs de reacteurs a caloporteur sodium

    Energy Technology Data Exchange (ETDEWEB)

    Poumerouly, S.

    2010-12-15

    Among all the types of accidents to be considered for the safety licensing of a plant, some have a very low probability of occurrence but might have very important consequences: the severe accidents or Hypothetical Core Disruptive Accidents (HCDA). The studies on the scenario of these accidents are performed in parallel to the prevention studies. In this PhD report, two representative safety cases are studied: the Unprotected Loss Of Flow (ULOF) and the Total Instantaneous Blockage (TIB). The objectives are to understand what causes the reactivity increase during these accidents and to find means to reduce the energetic release of the scenario (ULOF) or to find ways to trigger the core prior to the propagation of the accident (TIB). At first, the accidents are studied in static calculations with the ERANOS code system. The accidents are divided into several steps and the reactivity insertions at each step are explained. This study shows the importance of the removal of the structures as well as of the radial leakage changes during the core slumping-down. The study also gives the amounts of fuel to be ejected or of absorber to be injected in both accidents. These values give tracks to the following more accurate studies, the transient studies. The transient studies were performed with the SIMMER code system, coupling thermo-hydraulics and neutronics. SIMMER data and algorithms have been improved so as to better predict ERANOS results (former discrepancies were up to 1.5$). The SIMMER reactivity calculation is improved by 0.8$ with variations of reactivity due to the motion of materials correctly predicted. A new algorithm for the {beta}-effective was implemented in SIMMER so as to be more accurate and easier to manage. SIMMER is then used to calculate the secondary phase of the ULOF, while the primary phase is calculated with ERANOS thanks to some assumptions. The assumptions are very much based on the fact that the movement of materials stops whenever the energy

  4. Safety apparatus for serious radioactive accidents (1962); Materiel d'intervention en cas d'accident radioactif grave (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Estournel, R.; Rodier, J. [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1962-07-01

    In the case of a serious radioactive accident, radioactive dust and gases may be released into the atmosphere. It is therefore necessary to be able to evaluate rapidly the importance of the risk to the surrounding population, and to be able to ensure, even in the event of an evacuation of the Centre, the continuation of the radioactivity analyses and the decontamination of the personnel. For this, the Anti-radiation Protection Service at Marcoule has organised mobile detection teams and designed a mobile laboratory and a mobile shower-unit. After describing the duty of the mobile teams, the report gives a description of the apparatus which would be used at the Marcoule Centre in the case of a serious radioactive accident. The method of using this apparatus is given. (authors) [French] Lors d'un accident radioactif grave, des poussieres et des gaz radioactifs peuvent etre relaches dans l'atmosphere. II est alors indispensable d'evaluer rapidement l'importance du risque couru par les populations environnantes, et de pouvoir assurer, meme dans le cas de l'evacuation du Centre, la poursuite des analyses radioactives et la decontamination du personnel. Pour cela, le Service de Protection contre les Radiations du Centre de Marcoule a mis sur pied des equipes mobiles de detection et realise une semi-remorque laboratoire ainsi qu'une semi-remorque douches. Apres avoir defini la mission des equipes mobiles, le rapport donne la description du materiel d'intervention qui serait mis en oeuvre par le Centre de Marcoule dans le cas d'un accident radioactif grave. Il precis le mode d'utilisation de ce materiel. (auteurs)

  5. Décision d'amputation dans la prise en charge initiale d'une luxation ouverte grave de la cheville à propos d'un cas observé à l'Hôpital Laquintinie de Douala suite à un accident par moto-taxi

    Science.gov (United States)

    Tsatedem, Faustin Atemkeng; Tsiagadigui, Jean Gustave; Ndando, Richard Polle; Arabo, Mohamadou Saidou; Bayiha, Alphonse; Kenfack, Bruno

    2012-01-01

    La décision d'amputation pour traumatisme grave de membre n'est pas toujours facile à prendre. Les auteurs rapportent le cas d'un traumatisme ouvert de la cheville gauche avec luxation tibiotalienne complète, référé pour amputation. Il s'agit d'une passagère d'une moto-taxi percutée par une voiture. A l'admission, le pouls tibial postérieur était présent et le score dit MESS (Mangled Extremity Severity Score) côté à 5, ce qui a permis et d'éviter l'amputation. Après débridement et réduction, une broche transplantaire a permis d'immobiliser la cheville et de faire les pansements. L'amputation a été évitée. La cicatrisation dirigée de la peau a été suivie par la kinésithérapie. La mobilité de la cheville autorise une marche avec cannes au quatrième mois post-opératoire. Les auteurs recommandent l'utilisation du MESS dans la décision d'amputation après traumatisme grave de membre. PMID:23396997

  6. Study of the ruthenium fission-product behavior in the containment, in the case of a nuclear reactor severe accident; Etude du comportement du produit de fission ruthenium dans l'enceinte de confinement d'un reacteur nucleaire, en cas d'accident grave

    Energy Technology Data Exchange (ETDEWEB)

    Mun, Ch

    2007-03-15

    Ruthenium tetroxide is an extremely volatile and highly radio-toxic species. During a severe accident with air ingress in the reactor vessel, ruthenium oxides may reach the reactor containment building in significant quantities. Therefore, a better understanding of the RuO{sub 4}(g) behaviour in the containment atmosphere is of primary importance for the assessment of radiological consequences, in the case of potential releases of this species into the environment. A RuO{sub 4}(g) decomposition kinetic law was determined. Steam seems to play a catalytic role, as well as the presence of ruthenium dioxide deposits. The temperature is also a key parameter. The nature of the substrate, stainless steel or paint, did not exhibit any chemical affinities with RuO{sub 4}(g). This absence of reactivity was confirmed by XPS analyses, which indicate the presence of the same species in the Ru deposits surface layer whatever the substrates considered. It has been concluded that RuO{sub 4}(g) decomposition corresponds to a bulk gas phase decomposition. The ruthenium re-volatilization phenomenon under irradiation from Ru deposits was also highlighted. An oxidation kinetic law was determined. The increase of the temperature and the steam concentration promote significantly the oxidation reaction. The establishment of Ru behavioural laws allowed making a modelling of the Ru source term. The results of the reactor calculations indicate that the values obtained for {sup 106}Ru source term are closed to the reference value considered currently by the IRSN, for 900 MWe PWR safety analysis. (author)

  7. Épidémiologie des accidents domestiques graves de l'enfant admis en réanimation pédiatrique polyvalente à l'hôpital d'enfants de Rabat-Maroc

    Science.gov (United States)

    Rafai, Mostafa; Mekaoui, Nour; Chouaib, Naoufal; Bakkali, Hicham; Belyamani, Lahcen; El Koraichi, Alae; El Kettani, Salma Ech-Cherif

    2015-01-01

    Introduction Les accidents domestiques de l'enfant représentent un vrai problème de santé publique dans les pays industrialisés. Au Maroc, la priorité en santé publique est toujours donnée aux pathologies infectieuses, et bien qu'elle soit très peu décrite, la pathologie accidentelle de l'enfant devient de plus en plus fréquente dans notre pays avec une mortalité importante. L'objectif est de mettre le point sur la prévalence, la gravité, les aspects étiologiques, les facteurs de risque et les circonstances de survenue de ces accidents, ainsi que les moyens de prévention active et passive. Méthodes Enquête rétrospective descriptive sur une période de douze mois portant sur tous les enfants pris en charge pour accident domestique grave au service de réanimation pédiatrique polyvalente de l'hôpital universitaire d'enfants de Rabat. Résultats Parmi 698 admissions, 108 cas d'accidents domestiques graves ont étaient colligés (soit 15,5%), L’âge moyen des enfants était de 04ans tout accident confondu, avec un sex-ratio de 1,08 en faveur des garçons. L’évolution générale était marquée par le décès de 16 enfants (soit 14,8%) parmi 164 décès toute pathologie confondue au cours de la même période d’étude (soit 9,75% des décès) avec une durée moyenne d'hospitalisation de 04jours. les brûlures constituaient le premier accident dans notre série par 37cas, et elles étaient la première cause de mortalité par huit cas; par ailleurs, la population la plus à risque de brûlure était les nourrissons (67,6%). L'inhalation intrabronchique d’épingle à foulard (accident particulier dans notre contexte islamique) à été retrouvée chez six cas. Conclusion Les accidents domestiques de l'enfant constituent rarement une préoccupation de premier plan dans la population alors qu'ils sont parfois très graves et source d'une mortalité importante. Le meilleur traitement reste la prévention active et passive. PMID:26015848

  8. Décision d'amputation dans la prise en charge initiale d'une luxation ouverte grave de la cheville à propos d'un cas observé à l'Hôpital Laquintinie de Douala suite à un accident par moto-taxi

    OpenAIRE

    Tsatedem, Faustin Atemkeng; Tsiagadigui, Jean Gustave; Ndando, Richard Polle; Arabo, Mohamadou Saidou; Bayiha, Alphonse; Kenfack, Bruno

    2012-01-01

    La décision d'amputation pour traumatisme grave de membre n'est pas toujours facile à prendre. Les auteurs rapportent le cas d'un traumatisme ouvert de la cheville gauche avec luxation tibiotalienne complète, référé pour amputation. Il s'agit d'une passagère d'une moto-taxi percutée par une voiture. A l'admission, le pouls tibial postérieur était présent et le score dit MESS (Mangled Extremity Severity Score) côté à 5, ce qui a permis et d'éviter l'amputation. Après débridement et réduction, ...

  9. Un chercheur du CERN tué dans un accident

    CERN Multimedia

    2008-01-01

    The accident occured on Sunday between Collonges and Pougnu (Pays de Gex): 4 russians scientists were aboard the vehicle; the driver lost the control of the vehicle and the car made a barrel. (1/4 page)

  10. Le rôle de l’omalizumab dans le traitement de l’asthme allergique grave

    Science.gov (United States)

    Chapman, Kenneth R; Cartier, André; Hébert, Jacques; McIvor, R Andrew; Schellenberg, R Robert

    2006-01-01

    CONTEXTE : Un nouveau traitement anti-immunoglobuline E (anti-IgE) contre l’asthme, l’omalizumab, a été approuvé au Canada. OBJECTIF : Passer en revue les données fondamentales et cliniques sur l’omalizumab et examiner le rôle possible de ce médicament dans la prise en charge de l’asthme au Canada. MÉTHODOLOGIE : Une recherche documentaire a été effectuée dans MEDLINE afin de repérer les études menées de 1960 à 2006 sur l’omalizumab. La recherche a également porté sur les résumés de réunions scientifiques récentes dans le domaine des maladies respiratoires et des allergies; par ailleurs, toute donnée non publiée a été demandée au fabricant. Après avoir revu et résumé les données, un comité mixte constitué de spécialistes des maladies respiratoires et des allergies a rédigé un ensemble de recommandations relatives à l’utilisation de l’omalizumab. RÉSULTATS : L’omalizumab est un anticorps monoclonal humanisé qui se lie au domaine C epsilon 3 de la molécule d’IgE pour former des complexes immuns solubles qui sont éliminés par le système réticulo-endothélial. L’administration d’injections sous-cutanées espacées de deux ou de quatre semaines à la dose recommandée entraîne une diminution rapide des taux d’IgE circulantes libres. Lors de deux essais cliniques de phase III menés auprès de 1 405 adultes et adolescents atteints d’asthme modéré à grave qui recevaient des doses moyennes stables de corticostéroïdes en inhalation (CSI), l’omalizumab a diminué les taux d’exacerbation par rapport au placebo et a été associé à une amélioration des symptômes ainsi qu’à une épargne plus importante des corticostéroïdes. Dans un essai mené auprès de 419 patients atteints d’asthme grave non maîtrisé malgré l’utilisation de doses élevées de CSI et de la prise concomitante d’agonistes bêta-2 à action prolongée, les exacerbations graves étaient de 50 % moins fréquentes chez

  11. BENTUK KERJASAMA PUBLIC-PRIVATE PEMBANGUNAN GRAVING DOCK DAN MANAJEMEN GALANGAN KAPAL DENGAN METODE ANALYTICAL HIERARCHI PROCESS (AHP

    Directory of Open Access Journals (Sweden)

    Hartono Hartono

    2012-08-01

    Full Text Available In paper Development of port infrastructure in Indonesia is now no longer the responsibility of centralgovernment, along with limited funds and the government's insistence seaport infrastructure needs. Toaccelerate economic growth, the government issued Government Regulation as a legal umbrella. The purpose ofthis study was to examine public-private partnership opportunities in the construction of graving dock andshipyard management. Targets do is review, the criteria are prioritized cooperation and cooperationpriorities.This study used qualitative and quantitative approach, a descriptive qualitative approach throughinterviews used to assess the normative aspect. The quantitative approach used to assess the priority criteriaforms of cooperation and public-private partnership in development graving dock and shipyard management byusing the Analytical Hierarchy Process (AHP. Based on the AHP analysis can be concluded that the expertsdisagree about the priority criteria of cooperation, where the majority of them choose the duration as the maincriterion. As for the analysis of priorities of the cooperation of all experts choose Built-Operate-Transfer (BOT,which is deemed suitable for long-term investment of up to 30 years. BOT puts private partners to more freely tofinance, construct, operate, anticipated rate of return on capital (rate of return and the risks of commercial andregulatory aspects

  12. Radiometric evaluation of graves of victims of the accident with Cesium 137 in Goiania, GO, Brazil: 25 years after; Avaliacao radiometrica das sepulturas das vitimas do acidente com o Cesio 137 em Goiania: 25 anos apos

    Energy Technology Data Exchange (ETDEWEB)

    Lage, Leonardo B.; Correa, Rosangela da S.; Santos, Eliane E. dos, E-mail: leonardobl@cnen.gov.br, E-mail: rcorrea@cnen.gov.br, E-mail: esantos@cnen.gov.br [Centro Regional de Ciencias Nucleares do Centro-Oeste (CRCN-CO/CNEN-GO), Abadia de Goias, GO (Brazil); Freitas-Junior, Ruffo, E-mail: uffojr@terra.com.br [Universidade Federal de Goias (UFG), Goiania, GO (Brazil). Faculdade de Medicina. Programa de Mastologia

    2013-07-01

    Twenty-five years after the radiation accident in Goiania, this study aims to evaluate the radiological situation in the area demarcated by the graves of the victims of the accident with cesium-137. Radiometric survey was carried out on the surface that encompasses the four graves and vicinity, from a pre-established mesh. Dose rate measurements were carried out, using the IdentFINDER equipment, positioned at 1 m height from the ground. The values of dose rates at the points measured ranged from 0.03 to 0.07 μSv/h. This variation of dose rate is less than those obtained in the local graveyard and are in the range of background radiation observed in Goiania. Considering the results obtained 25 years after the accident, it was concluded that engineering barriers adopted at that time are effective, stating the place absolutely safe from a radiological point of view, both for the individual from the public as to the environment.

  13. [Graves' ophthalmopathy].

    Science.gov (United States)

    Badelon, Isabelle; Morax, Serge

    2005-01-31

    Graves' ophthalmopathy (GO) is a chronic autoimmune process that affects the retrobulbar tissue and has strong etiological links with graves' disease. Pathogenesis is incompletely understood. Symptoms include proptosis, extraocular muscle dysfunction, eyelid swelling and retraction. In its severe expression, it is a disfiguring and potentially sight threatening disease that profoundly influences and impairs the quality of life of affected individuals. Only a minority of patients develop severe expressions of the disease, requiring aggressive treatments. Glucocorticoids, orbital radiotherapy and decompressive orbital surgery represent a mainstay and a well established treatment for severe and active GO.

  14. Management of a severe accident on a pressurised water reactor in France; La gestion d'un accident grave sur un reacteur a eau sous pression en France

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This brief document defines what a severe accident is on a nuclear reactor, indicates the different failure modes which have been defined (vapour explosion in the reactor vessel, hydrogen explosion, and so on). It describes the management of a core fusion accident for pressurized water reactors, for which a guide has been designed, the GIAG (intervention guide for a severe accident situation). The principles of such an intervention are described, and then the approach for an EPR reactor

  15. [Graves' ophthalmopathy].

    Science.gov (United States)

    Eckstein, A; Dekowski, D; Führer-Sakel, D; Berchner-Pfannschmidt, U; Esser, J

    2016-04-01

    Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease and the full clinical picture can impair the quality of life of the patients considerably. Active inflammation can often be effectively treated by intravenous steroids/immunosuppression, however does not lead to full remission, since inflammation rather quickly results in irreversible fibrosis and increase of orbital fat. Very important is the control of risk factors (smoking cessation, good control of thyroid function, selenium supplementation) to prevent progression to severe stages. Treatment should rely on a thorough assessment of activity and severity of GO. Rehabilitative surgery (orbital decompression, squint surgery, eyelid surgery) is needed in many patients to restore function and appearance. Anti-thyroid-stimulating hormone (TSH) receptor antibodies do specifically occur in these patients and correlate to the course of thyroid and eye disease. The levels of these antibodies can be used for treatment decisions at certain time points of the disease.

  16. Envenimation scorpionique compliqué d'un accident vasculaire cérébral ischemique

    OpenAIRE

    2015-01-01

    Les piqûres de scorpion sont dans un certain nombre de pays, un accident fréquemment rencontré, et un risque grave. Au Maroc, les données épidémiologiques établies par le centre anti-poison (CAPM) montrent que les piqûres scorpioniques se placent en tête de toutes les intoxications relevées par le centre (60%). Les envenimations scorpioniques posent un grand problème de santé publique. L'apparition de signes neurologiques lors d'une envenimation scorpionique témoigne d'une envenimation grave ...

  17. L'hemorragie grave du peripartum en milieu de reanimation dans un centre universitaire tunisien de niveau 3: épidémiologie et facteurs de risque de mortalité maternelle

    Science.gov (United States)

    Nasr, Laidi Ben; Marzouk, Sofiene Ben; Kehila, Mehdi; Jabri, Hamed; Thamleoui, Saber; Maghrebi, Hayen

    2015-01-01

    L'hémorragie grave du péripartum demeure une des causes principales de mortalité maternelle. L'objectif de notre étude était de décrire le profil épidémiologique des patientes qui ont été prises en charge en milieu de réanimation suite à une hémorragie grave du péripartum et de rechercher d’éventuels facteurs de risque de mortalité. Notre étude est rétrospective descriptive et analytique. Nous avons inclus tous les cas d'hémorragie du péripartum ayant séjourné en unité de réanimation obstétricale du centre de maternité et de néonatologie de Tunis (CMNT) au cours de la période allant de janvier 2010 à Décembre 2013. Nous avons recueilli les paramètres démographiques, obstétricaux, ceux relatifs à la prise en charge chirurgicale et réanimatoire, les scores de gravité SAPS obstétrical et APACHEII, ainsi que la morbi-mortalité. Au total nous avons colligé 322 cas sur quatre ans. La répartition annuelle des patientes ainsi que les caractéristiques démographiques et obstétricales étaient comparables dans leur globalité sur les quatre années. Les pratiques thérapeutiques étaient également comparables. Le taux global de mortalité par hémorragie dans notre unité était à 4,7%, avec un taux annuel de mortalité stable. L'analyse des facteurs de risque de mortalité par hémorragie en milieu de réanimation a montré une association statistiquement significative entre la survenue du décès et les facteurs suivants: recours aux catécholamines, survenue de sepsis, œdème pulmonaire aigu, coagulation intravasculaire disséminée, insuffisance rénale aigue avec recours à l'hémodialyse, SDRA ou TRALI, atteinte neurologique grave, défaillance multiviscérale et arrêt cardiaque récupéré. PMID:26587127

  18. Major accidents involving dangerous chemicals and Standard Basic Self-Protection; Accidentes graves en los que intervangan sustancias quimica peligrosas y Norma Basica de Autoproteccion

    Energy Technology Data Exchange (ETDEWEB)

    Alonso Fernandez, L.

    2011-07-01

    Nuclear and radioactive facilities and other centers, institutions and agencies engaged in activities that may lead to emergency situations, are subject to specific regulations directed to take measures to prevent and control risks at source and to act initially in emergency situations and limit the consequences, in order to protect people, property and the environment. With these premise, place the following article, which summarizes the basic guidelines in the field of major accident and self-protection, summarizing the implications of current legislation in this field. (Author)

  19. Ampleur et impact des évènements indésirables graves liés aux soins: étude d'incidence dans un hôpital du Centre-Est tunisien

    Science.gov (United States)

    Bouafia, Nabiha; Bougmiza, Iheb; Bahri, Fathi; Letaief, Mondher; Astagneau, Pascal; Njah, Mansour

    2013-01-01

    Introduction La prévention des événements indésirables représente une priorité de santé du fait de leur fréquence et de leur gravité potentielle. Ce travail a été mené afin d'avoir un diagnostic de la situation épidémiologique relative aux événements indésirables survenant dans notre hôpital. Méthodes Une étude prospective a été menée auprès de tous les patients qui ont été hospitalisés au CHU Farhat Hached - Sousse (Tunisie) sur une période d'un mois dans quatorze services de l'hôpital. La détection d'évènement indésirable grave (EIG) était basée sur les critères adoptés dans différentes études. Les tests T et Chi 2 ont été utilisés pour identifier les facteurs contribuant à l'apparition d'évènements indésirables. Résultats Au total, 162 EIG ont été identifiés pendant la période. 45% de ces évènements étaient des infections nosocomiales. Ces EIG ont eu comme conséquences un décès chez 9,2% des patients, la mise en jeu du pronostic vital de 26% des patients et la prolongation de la durée de séjour chez 61,7% d'entre eux. L'admission dans des circonstances particulières et l'exposition à des soins invasifs étaient identifiés comme des facteurs de risque potentiels EIG. Conclusion Le renforcement de la stratégie de gestion des risques sanitaires en ciblant préférentiellement le risque infectieux constitue une étape fondamentale dans l'amélioration de la sécurité des patients au sein de notre établissement de santé. PMID:24711868

  20. Contribution of prototypic material tests on the Plinius platform to the study of nuclear reactor severe accident; Contribution des essais en materiaux prototypiques sur la plate-forme Plinius a l'etude des accidents graves de reacteurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Journeau, Ch

    2008-01-15

    The PLINIUS experimental platform at CEA Cadarache is dedicated to the experimental study of nuclear reactor severe accidents thanks to experiments between 2000 and 3500 K with prototypic corium. Corium is the mixture that would be formed by an hypothetical core melting and its mixing with structural materials. Prototypical corium has the same chemical composition as the corium corresponding to a given accident scenario but has a different isotopic composition (use of depleted uranium,...). Research programs and test series have been performed to study corium thermophysical properties, fission product behaviour, corium spreading, solidification and interaction with concrete as well as its coolability. It was the frame of research training of many students and was realized within national, European and international collaborations. (author)

  1. Graves' Disease Associated with Cerebrovascular Disease and Antiphospholipid Antibody Syndrome

    Directory of Open Access Journals (Sweden)

    Ines Khochtali

    2010-01-01

    have increased risk for developing thromboembolic accidents, which are favoured by a simultaneous presence of antiphospholipid antibodies syndrome. in this paper, we describe the case of a patient with Graves' disease, who developed strokes with antiphospholipid antibodies syndrome.

  2. Material effects on multiphase phenomena in late phases of severe accidents of nuclear reactors; Effets des materiaux sur les phenomenes multiphasiques se produisant lors des phases avancees d'accident grave de reacteur nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Seiler, J.M.; Froment, K

    2003-07-01

    This paper reviews and presents work carried out in the French Atomic Energy Commission (CEA) on the subject of nuclear severe accidents, i.e. those which are accompanied by melting of the nuclear core material. The emphasis is on the (crucial) thermodynamic and material behaviour of corium melts in the solidus-liquidus temperature interval, which is linked to the thermal hydraulic description. A global model approach is proposed. The work is presented in the context of the overall international effort in the area. (authors)

  3. Fukushima accident: the consequences in Japan, France and in Japan; Accident de Fukushima: les repercusions au Japon, en France et dans le Japon

    Energy Technology Data Exchange (ETDEWEB)

    Foucher, N.; Sorin, F.

    2011-03-15

    This document begins with a description of the Fukushima accident, the second article reviews the main consequences in Japan of the accident: setting of a forbidden zone around the plant, restriction of the exports of food products, or the shutdown of the Hamaoka plant. The third article is the reporting of an interview of L. Oursel, deputy general director of the Areva group, this interview deals mainly with the safety standard of the EPR and with the issue of passive safety systems. The last part of the document is dedicated to the consequences in France (null sanitary impact, cooperation between Areva, EdF, CEA and the Japanese plant operator Tepco...) and in the rest of the world: the organization of resistance tests in the nuclear power plants operating in the European Union, the decision about the agreement of EPR and AP1000 reactor has been delayed in United-Kingdom, acceleration of the German program for abandoning nuclear energy, Italy suspends its nuclear program, China orders a general overhaul of the safety standard of its nuclear power plants, Poland and Romania reaffirm their trust in nuclear energy, France wishes a 'mechanism' allowing a quick international intervention in case of major nuclear accident, Russia proposes measures to improve nuclear safety. (A.C.)

  4. Les accidents du travail dans le transport urbain en commun de la ville province de Kinshasa, République Démocratique du Congo: une étude transversale descriptive

    Science.gov (United States)

    Wangata, Jemima; Elenge, Myriam; De Brouwer, Christophe

    2014-01-01

    Introduction Le transport en commun urbain constitue un secteur où les travailleurs sont très exposés aux accidents du travail. Cette étude visait une description épidémiologique des accidents du travail dans le secteur informel du transport en commun à Kinshasa en vue d'apporter les pistes d'amélioration de la sécurité des travailleurs dans cette activité. Méthodes Un questionnaire sur les accidents du travail, administré en Décembre 2012 a permis d'explorer les tendances significatives entre les accidents et leurs circonstances, leurs facteurs associés, leurs conséquences au sein d'une population des travailleurs (n = 472) du transport en commun à Kinshasa. Résultats Durant les 12 derniers précédant l’étude 76.5% des travailleurs ont connu au moins un accident du travail, 54,8% ont connu un arrêt d'au moins 1jour. Les accidents liés à la circulation routière étaient plus important suivis des chutes. Les facteurs ayant montré des différences significatives étaient le travail sous l'influence de l'alcool et le port des équipements de protection individuelle. Les plaies (46,3%) et les contusions (39,4%) étaient les lésions les plus courantes. Les membres supérieurs (51,3%) et inférieurs (30,7%) étaient les plus atteints. 76,6% des travailleurs ont assumé seuls leur prise en charge médicale. Conclusion L'incidence des accidents du travail dans ce secteur est très élevée. La mise en place d'une politique de prévention et gestion de différents facteurs associés ainsi qu'un système de déclaration d'accidents est nécessaire dans ce secteur. Les patrons ainsi que les politiques devraient veiller à une prise en charge médicale correcte pour des travailleurs accidentés. PMID:25667703

  5. Chernobyl in the French mass media 14 years after the accident; Tchernobyl dans la presse francaise 14 ans apres

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2001-02-01

    The author presents how the mass media have dealt with the fourteenth anniversary of the Chernobyl accident. Nowadays Chernobyl epitomizes the hazards of nuclear energy. Public opinion has become extremely sensitive to topics concerning human health. This sensitivity is due to previous important affairs such as the scandal of the tainted blood, the mad cow disease or the syndrome of the Balkan war. Most media have broadened the debate to the sanitary impact of nuclear activities. The hyper-mediatization of the legal case of a man prosecuting the French state for no having taken adequate measures when the radioactive cloud spread over France, has given the feeling that French authorities have always wrongly minimized the consequences of the accident. (A.C.)

  6. Accidents - Chernobyl accident; Accidents - accident de Tchernobyl

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This file is devoted to the Chernobyl accident. It is divided in four parts. The first part concerns the accident itself and its technical management. The second part is relative to the radiation doses and the different contaminations. The third part reports the sanitary effects, the determinists ones and the stochastic ones. The fourth and last part relates the consequences for the other European countries with the case of France. Through the different parts a point is tackled with the measures taken after the accident by the other countries to manage an accident, the cooperation between the different countries and the groups of research and studies about the reactors safety, and also with the international medical cooperation, specially for the children, everything in relation with the Chernobyl accident. (N.C.)

  7. Graves disease (image)

    Science.gov (United States)

    Graves disease is an autoimmune disorder that involves overactivity of the thyroid gland (hyperthyroidism). Hallmarks of the condition are bulging eyes (exophthalmos), heat intolerance, increased energy, difficulty sleeping, diarrhea, and anxiety.

  8. Graves' Disease Associated with Cerebrovascular Disease and Antiphospholipid Antibody Syndrome

    OpenAIRE

    2010-01-01

    Thyroid disorders are commonly associated with coagulopathy. Patients with hyperthyroidism have increased risk for developing thromboembolic accidents, which are favoured by a simultaneous presence of antiphospholipid antibodies syndrome. in this paper, we describe the case of a patient with Graves' disease, who developed strokes with antiphospholipid antibodies syndrome.

  9. Graves' ophthalmopathy: interdisciplinary approach

    Directory of Open Access Journals (Sweden)

    O I Vinogradskaya

    2010-12-01

    Full Text Available Graves' ophthalmopathy constitutes a major therapeutic challenge, so specialists of various disci-plines have to combine their forces. According to the last consensus of EUGOGO (European Group On Graves' Orbitopathy the treatment of choice for Graves' ophthalmopathy is pulses of glucocorticoid (GC. Evidence for the superiority of any of the different intravenous (iv glucocorticoid schedules is lacking. Objective: to evaluate the efficacy of two different methylprednisolone pulse therapy schedules in Graves' ophthalmopathy. Materials and Methods: 30 Graves' patients with Graves' ophthalmopathy were subcategorized into two groups: Group A subjects (n = 14 were given iv glucocorticoid daily for 5 days (total 5 g and Group B patients (n = 16 were given iv glucocorticoid weekly for 5 weeks (total 5 g. All patients were examined by the ophthalmologist before and in 1 and 12 weeks after the treatment. Results: We found that in group A visual acuity was significantly higher than in group B at 12 weeks. By 12 week proptosis, diplopia had improved as well as CAS had fallen in two groups but there were no significant differences between the two groups. Conclusion: Both schedules are effective on proptosis, soft tissue swelling. Daily pulse therapy appeared to be more effective on visual acuity. Thereby in case of active Graves' ophthalmopathy associated with impairment of visual acuity, daily pulse therapy is a treatment of choice. But, in spite of improvement, strabismus, diplopia, proptosis have a marked negative effect on quality of life, disturb a lifestyle. In these cases surgery should be considered. After end of our research two patients (3 orbits had bone decompression with a good result. We consider that eye muscle surgery is next needed to restore their binocular vision.

  10. Modeling Graves' Orbitopathy in Experimental Graves' Disease.

    Science.gov (United States)

    Banga, J P; Moshkelgosha, S; Berchner-Pfannschmidt, U; Eckstein, A

    2015-09-01

    Graves' orbitopathy (GO), also known as thyroid eye disease is an inflammatory disease of the orbital tissue of the eye that arises as a consequence of autoimmune thyroid disease. The central feature of the disease is the production of antibodies to the thyrotropin hormone receptor (TSHR) that modulate the function of the receptor leading to autoimmune hyperthyroidism and GO. Over the years, all viable preclinical models of Graves' disease have been incomplete and singularly failed to progress in the treatment of orbital complications. A new mouse model of GO based upon immunogenic presentation of human TSHR A-subunit plasmid by close field electroporation is shown to lead to induction of prolonged functional antibodies to TSHR resulting in chronic disease with subsequent progression to GO. The stable preclinical GO model exhibited pathologies reminiscent of human disease characterized by orbital remodeling by inflammation and adipogenesis. Inflammatory lesions characterized by CD3+ T cells and macrophages were localized in the orbital muscle tissue. This was accompanied by extensive adipogenesis of orbital fat in some immune animals. Surprisingly, other signs of orbital involvement were reminiscent of eyelid inflammation involving chemosis, with dilated and congested orbital blood vessels. More recently, the model is replicated in the author's independent laboratories. The pre-clinical model will provide the basis to study the pathogenic and regulatory roles of immune T and B cells and their subpopulations to understand the initiation, pathophysiology, and progression of GO.

  11. L'hemorragie grave du peripartum en milieu de reanimation dans un centre universitaire tunisien de niveau 3: épidémiologie et facteurs de risque de mortalité maternelle

    OpenAIRE

    Nasr, Laidi Ben; Marzouk, Sofiene Ben; Kehila, Mehdi; Jabri, Hamed; Thamleoui, Saber; Maghrebi, Hayen

    2015-01-01

    L'hémorragie grave du péripartum demeure une des causes principales de mortalité maternelle. L'objectif de notre étude était de décrire le profil épidémiologique des patientes qui ont été prises en charge en milieu de réanimation suite à une hémorragie grave du péripartum et de rechercher d’éventuels facteurs de risque de mortalité. Notre étude est rétrospective descriptive et analytique. Nous avons inclus tous les cas d'hémorragie du péripartum ayant séjourné en unité de réanimation obstétri...

  12. Study of diluting and absorber materials to control reactivity during a postulated core melt down accident in Generation IV reactors; Etude des materiaux sacrificiels absorbants et diluants pour le controle de la reactivite dans le cas d'un accidnet hypothetique de fusion du coeur de reacteurs de quatrieme generation

    Energy Technology Data Exchange (ETDEWEB)

    Plevacova, K.

    2010-12-16

    In order to limit the consequences of a hypothetical core meltdown accident in Generation IV Sodium Fast Reactors, absorber materials in or near the core, such as boron carbide B{sub 4}C, and diluting materials in the core catcher will be used to prevent recriticality within the mixture of molten oxide fuel and molten structures called corium. The aim of the PhD thesis was to select materials of both types and to understand their behaviour during their interaction with corium, from chemical and thermodynamic point of view. Concerning B{sub 4}C, thermodynamic calculations and experiments agree with the formation of two immiscible phases at high temperature in the B{sub 4}C - UO{sub 2} system: one oxide and one boride. This separation of phases can reduce the efficiency of the neutrons absorption inside the molten fuel contained in the oxide phase. Moreover, a volatilization of a part of the boron element can occur. According to these results, the necessary quantity of B{sub 4}C to be introduced should be reconsidered for postulated severe accident sequence. Other solution could be the use of Eu{sub 2}O{sub 3} or HfO{sub 2} as absorber material. These oxides form a solid solution with the oxide fuel. Concerning the diluting materials, mixed oxides Al{sub 2}O{sub 3} - HfO{sub 2} and Al{sub 2}O{sub 3} - Eu{sub 2}O{sub 3} were preselected. These systems being completely unknown to date at high temperature in association with UO{sub 2}, first points on the corresponding ternary phase diagrams were researched. Contrary to Al{sub 2}O{sub 3} - Eu{sub 2}O{sub 3} - UO{sub 2} system, the Al{sub 2}O{sub 3} - HfO{sub 2} - UO{sub 2} mixture presents only one eutectic and thus only one solidification path which makes easier forecasting the behaviour of corium in the core catcher. (author) [French] Resume: Afin de limiter les consequences d'un accident grave avec la fusion du coeur dans un reacteur a neutrons rapides de generation IV refroidi au sodium, la recriticite doit

  13. Graves orbitopathy: a perspective.

    Science.gov (United States)

    Perros, Petros; Krassas, Gerasimos E

    2009-06-01

    Advances in the past few years have helped clinicians understand some of the pathogenetic mechanisms of Graves orbitopathy (GO), particularly the role of receptors for TSH and insulin-like growth factor I in the orbit. Optimal treatment strategies have been formulated and published by the European Group on Graves' Orbitopathy, which are hoped to improve the management of patients with this condition. The administration of intravenous pulses of steroids has been established as a superior treatment approach compared with other steroid regimens. In addition, orbital radiotherapy was effective in a subgroup of patients with GO who had eye dysmotility. The use of immunotherapies for the treatment of GO is currently being explored; of these, rituximab has emerged as a promising new agent.

  14. Højfolkets Grave

    DEFF Research Database (Denmark)

    2007-01-01

    For the special exhibition 'Højfolkets Grave - Oak Coffins from Borum Eshøj' on Moesgaard Museum in 2007: The development of 3D graphics which was displayed on a big screen in the exhibition. The animation shows - in a very stylistic way - the design principles behind the construction of Bronze Age...... burial mounds, based on the excavation results from the mound Skelhøj....

  15. Digging One's Own Grave

    Directory of Open Access Journals (Sweden)

    Arvo Krikmann

    2007-01-01

    Full Text Available The paper aims to demonstrate that some points in the explicationof the figurative expression digging one’s own grave via the concept of blending given by Gilles Fauconnier and Mark Turner are problematic: (1 Not understanding the consequences of one’s deeds is an almost universal presuppositionof and impulse or motivation for actualizing any utterance with a forewarning or gloating content (e.g., proverbs, not the singularity characterizing just the expression of grave-digging as such. (2 The inversion of causal and temporal structure is not the case because of metonymic association between the concepts of the grave and death, as a result of which specific causal and temporal order loses any significance. Many synonymous examples can be given in which the image refers to events before the death, between the death and funeral, as well as those after burial. (3 The source domain needs not to be restricted to natural death and modern civilized funerals but should include also the cases of violent deaths, e.g., the scenario of execution and the scenario of hunting and trapping. Preliminarily, a very brief synopsis of the main phases of development of cognitive linguistic theory of metaphor and some favourite examples of blends, used also in previous works, is provided.

  16. SARNET european excellence network on nuclear reactor major accidents. Display and realizations after a year of operating; Sarnet reseau d'excellence europeen sur les accidents graves de reacteur nucleaire. Son deploiement et ses realisations apres une annee de fonctionnement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-03-15

    The Sarnet (Severe Accident Research NETwork of excellence) is devoted to the research on major accidents of water cooled reactors. The developed knowledge will be integrated in a simulation tool ASTEC co-developed with the IRSN and the GRS. This evaluation report presents the context, the objectives and the program of the Sarnet network. It discusses the network operating and the ASTEC simulation code. Some examples of experimental programs are provided. (A.L.B.)

  17. Avancée dans la prévention des « chutes de plain-pied » au travail Progress in the prevention of occupational “falls on the same level”. Proposed operational definition of a new category: “Motion perturbation accidents (MPAs” Avances en la prevención de « caídas al mismo nivel » en el trabajo. Propuesta de la definición operacional de una nueva categoría : « los Accidentes con Perturbación del Movimiento (APM »

    Directory of Open Access Journals (Sweden)

    Sylvie Leclercq

    2010-11-01

    Full Text Available La chute de plain-pied reste un accident du travail fréquent et grave. La terminologie qualifiant ces accidents est variée, relativement imprécise et n’intègre pas la diversité des accidents rencontrés sous les différentes appellations. L’intérêt de considérer une catégorie d’accidents du travail avec perturbation du mouvement (APM est tout d’abord mis en évidence à partir de divers extraits de récits d’accidents. Un modèle est ensuite proposé pour les APM montrant que, dans ces cas particuliers d’accident la blessure est souvent la conséquence de l’association fortuite entre l’énergie du mouvement perturbé de la victime et un élément matériel rendu blessant de par ses propriétés et appelé a posteriori un « danger circonstanciel ». Enfin, le raisonnement qui sous-tend la classification de ces accidents est explicité. Il apparaît notamment que la prévention ciblant les causes immédiates de la blessure est difficile voire impossible dans les cas d’APM en raison principalement des exigences inhérentes au travail et de contraintes que ferait peser sur l’entreprise l’application de cette prévention. La prévention à la source du risque tend alors à devenir la seule possible. Ainsi, de banal, l’APM devient un révélateur de dysfonctionnements au sein du système de production.Falls on the same level remain frequent and serious occupational accidents. The terminology used to describe these accidents is varied and somewhat imprecise. Moreover it does not integrate the variety of accidents with different names. The advantage of considering an occupational accident category with motion perturbation (MPA is demonstrated, based on extracts from various occupational accident accounts. A model is then proposed for MPAs that shows that in these specific cases of accidents, the injury often results from a fortuitous association between the victim’ perturbed motion energy and a physical element that

  18. Thymic hyperplasia in Graves' disease.

    Science.gov (United States)

    Kotwal, Narendra; Singh, Yashpal; Menon, Anil; Behera, Vineet

    2013-05-01

    Graves' disease is an autoimmune thyroid condition characterized by the production of autoantibodies against the thyrotropin receptor. It is known to be associated with autoimmune conditions such as myasthenia gravis, Addison's disease, type 1 diabetes mellitus, and vitiligo. We present a case of rare autoimmune association of Graves' disease with thymic hyperplasia which regressed after treatment with antithyroid drugs. Exact pathophysiology of thymic hyperplasia in Graves' is not well understood; it is likely to be the result of rather than the cause of Graves' disease.

  19. Study of top reflooding in case of severe accident and in particular oxidation of Uranium, Zirconium, Oxygen melts; Etude du renoyage par le haut en cas d'accident grave et en particulier oxydation des melanges (U,Zr,O)

    Energy Technology Data Exchange (ETDEWEB)

    Brunet-Thibault, E

    2006-12-15

    In 1979, the Three Mile Island (TMI) accident occurred in United States and accelerated research activities in the field of severe accidents. Severe accident management procedures imply massive water injections to flood the core. The work of this thesis bent principally over this reflooding. The first part of the study concerns the core oxidation enhancement during the reflooding phase which leads to a rough increase of the concentration of burnable hydrogen in the containment. This is why the study carried on the analysis of the contribution of the oxidation of U-Zr-O mixtures, towards the total production of hydrogen during reflooding. In the second part, the study concerns top flooding modelling i.e.: with injection of water in the hot legs. Here, we attempted to define bases and realize a model allowing to describe this type of reflooding. These models were validated on the simulation of the parameter with MAAP4 code. (author)

  20. Pathophysiology of Graves' ophthalmopathy.

    Science.gov (United States)

    Stiebel-Kalish, Hadas; Robenshtok, Eyal; Gaton, Dan D

    2010-03-01

    Pathohistological characteristics of Graves' ophthalmopathy (GO) include glycosaminoglycan deposition in the orbit, active inflammatory process, fibrosis of the extra-ocular muscles and fat accumulation within the orbit. These processes lead to the clinical manifestations of proptosis, chemosis, periorbital edema, and altered ocular motility. Current evidence demonstrates that GO is not a result of hyperthyroidism but rather represents a second target of the underlying autoimmune process. The candidate orbital autoantigens and the cells involved in the development and progression of GO are reviewed. The initiation and propagation of the autoimmune process against such antigens involves a complex action of lymphocytes and auto-antibodies. At least three cell types are involved in the unique remodeling of orbital tissues of GO patients: T cells, orbital fibroblasts, and B cells through the production of autoantibodies. These are further discussed in this review. In Graves' hyperthyroidism, autoantibodies to TSH receptors (TSH-R) may affect thyroid function by stimulating TSH-R, promoting excessive thyroid growth, hormone production and secretion receptor which stimulates TSH receptor mRNA and expression. The correlation of TSH-Abs levels with GO activity is used clinically as a marker of disease activity, to aid prediction of the disease course, and to support GO diagnosis in patients with no clinically significant thyroid disease. Several future specific therapies under investigation are mentioned. These are aimed against the autoantibodies, the orbital fibroblasts or the peroxisome proliferator-activated receptor gamma (PPARgamma), which regulates fatty acid storage and glucose metabolism.

  1. Modeling in fast dynamics of accidents in the primary circuit of PWR type reactors; Modelisation en dynamique rapide d'accidents dans le circuit primaire des reacteurs a eau pressurisee

    Energy Technology Data Exchange (ETDEWEB)

    Robbe, M.F

    2003-12-01

    Two kinds of accidents, liable to occur in the primary circuit of a Pressurized Water Reactor and involving fast dynamic phenomena, are analyzed. The Loss Of Coolant Accident (LOCA) is the accident used to define the current PWR. It consists in a large-size break located in a pipe of the primary circuit. A blowdown wave propagates through the circuit. The pressure differences between the different zones of the reactor induce high stresses in the structures of the lower head and may degrade the reactor core. The primary circuit starts emptying from the break opening. Pressure decreases very quickly, involving a large steaming. Two thermal-hydraulic simulations of the blowdown phase of a LOCA are computed with the Europlexus code. The primary circuit is represented by a pipe-model including the hydraulic peculiarities of the circuit. The main differences between both computations concern the kind of reactor, the break location and model, and the initialization of the accidental operation. Steam explosion is a hypothetical severe accident liable to happen after a core melting. The molten part of the core (called corium) falls in the lower part of the reactor. The interaction between the hot corium and the cold water remaining at the bottom of the vessel induces a massive and violent vaporization of water, similar to an explosive phenomenon. A shock wave propagates in the vessel. what can damage seriously the neighbouring structures or drill the vessel. This work presents a synthesis of in-vessel parametrical studies carried out with the Europlexus code, the linkage of the thermal-hydraulic code Mc3d dedicated to the pre-mixing phase with the Europlexus code dealing with the explosion, and finally a benchmark between the Cigalon and Europlexus codes relative to the Vulcano mock-up. (author)

  2. [Radiotherapy for Graves' ophthalmopathy].

    Science.gov (United States)

    Kuhnt, T; Müller, A C; Janich, M; Gerlach, R; Hädecke, J; Duncker, G I W; Dunst, J

    2004-11-01

    Graves' ophthalmopathy (GO) is the most frequent extrathyroidal manifestation of Graves' disease, an autoimmune disorder of the thyroid, whereas the precise pathogenesis still remains unclear. In Hashimoto's thyroiditis the occurrence of proptosis is an extremely rare event. The therapy for middle and severe courses of GO shows in partly disappointing results, although several therapy modalities are possible (glucocorticoid therapy, radiotherapy, antithyroid drug treatment, surgery). All these therapies lead in only 40 - 70 % to an improvement of the pathogenic symptoms. An intensive interdisciplinary cooperation is necessary to satisfy the requirements for the treatment of Graves' ophthalmopathy. As a consequence of the very different results of the few of clinical studies that were accomplished with reference to this topic, treatment by radiotherapy in the management of the disease is presently controversially discussed. In the German-speaking countries the radiotherapy is, however, firmly established as a therapy option in the treatment of the moderate disease classes (class 2-5 according to NO SPECS), especially if diplopia is present. This article describes the sequences, dosages and fractionation schemes as well as the risks and side effects of the radiotherapy. Altogether, radiotherapy is assessed as an effective and sure method. The administration of glucocorticoids can take place before the beginning of or during the radiotherapy. For the success of treatment the correct selection of patients who may possibly profit from a radiotherapy is absolutely essential. By realising that GO proceeds normally over a period of 2-5 years, which is followed by a period of fibrotic alteration, the application of the radiotherapy in the early, active phase is indispensable. A precise explanation for the effects of radiotherapy in treatment of the GO does not exist at present. The determination of the most effective irradiation doses was made from retrospectively evaluated

  3. Fisiopatologia da asma grave

    OpenAIRE

    Todo-Bom, Ana; Mota-Pinto, Anabela

    2006-01-01

    Não tem resumo. Transcreve-se o primeiro parágrafo: A história natural da asma e os condicionalismos de uma evolução para formas moderadas ou graves não está completamente estabelecida. Contudo, quer os factores genéticos quer os factores ambientais, serão determinantes na fisiopatologia e no prognóstico da doença. A asma é, por definição, uma doença inflamatória crónica das vias aéreas caracterizada por uma obstrução brônquica generalizada mas variável que é, pelo menos parcialmente, reve...

  4. Epidemiology of Graves' orbitopathy.

    Science.gov (United States)

    Putta-Manohar, Sudeep; Perros, Petros

    2010-03-01

    Thyroid orbitopathy is a relatively rare disease. Prevalence data are lacking and can only be estimated. The incidence of thyroid orbitopathy has been documented in one American study (16 cases per 100,000 population per year for females and 2.9 cases per 100,000 population for males). Thyroid orbitopathy can affect every race and age group. The majority of patients present in middle age with concurrent thyrotoxicosis due to Graves' disease. The onset of orbitopathy usually coincides with the hyperthyroidism, though the two may be asynchronous by months or sometimes years. A small proportion of patients with thyroid orbitopathy have primary hypothyroidism or are euthyroid. Female patients outnumber males by 2-5 to 1. Smoking increases the risk of thyroid orbitopathy up to 8-fold.

  5. Fluxes of radionuclides in the agricultural production after a nuclear accident: countermeasures and decontamination techniques; Flux des radionucleides dans les productions agricoles suite a un accident nucleaire: contre-mesures et techniques de rehabilitation

    Energy Technology Data Exchange (ETDEWEB)

    Jouve, A. [CEA Centre d`Etudes Nucleaires de Cadarache, 13 -Saint-Paul-lez-Durance (France)]|[Universite de Provence, 13 - Marseille (France)

    1997-12-31

    This thesis deals with the radiological consequences of a nuclear accident through the radioactive contamination of the food chain and the subsequent countermeasures for decreasing the fluxes of radionuclides and decontaminating agricultural lands. After a brief summary of the radioprotection ground and context in case of a nuclear accident, this work surveys existing data on the fluxes of radionuclides in soils and from soil to plants. The research work focuses on both the prediction of the fluxes of radionuclides and possible countermeasures: the measurement of the bioavailability of radionuclides in the soil solution, its use in a mathematical expression to quantify the soil-to-plant transfer of caesium and strontium, and the perspectives of an innovative technique of soil decontamination. The obtained results show that based on 4 coefficients, it is possible to predict crop contamination within a 3 % confidence interval: the fluid solid distribution coefficient of radionuclides kd, the amount of chemical analogues of caesium and strontium, i.e. potassium and calcium, respectively, soil pH and a constant characterising the plant species that is concerned. However, it generally appears from soil to plant transfer studies that the reduction of the fluxes of radionuclides is not a promising way of radiological exposure mitigation after a nuclear accident. The work performed shows that it is more efficient to tackle the source of the contamination, i.e. decontaminate the soil. The proposed technique of soil scraping using a turf harvester appears to be the most advantageous among the tested options, for the decontamination of peat-bog meadows. (author).

  6. Hashimoto's thyroiditis following Graves' disease.

    Science.gov (United States)

    Umar, Husaini; Muallima, Nur; Adam, John M F; Sanusi, Harsinen

    2010-01-01

    Both Graves' disease and chronic thyroiditis (Hashimoto's thyroiditis) are autoimmune diseases of thyroid gland. Graves' disease is caused by stimulation of TSH receptor located on the thyroid gland by an antibody, which is known as TSH receptor antibody (TRAb). Furthermore, this may lead to hyperplasia and hyperfunction of the thyroid gland. On the contrary, the cause of Hashimoto's thyroiditis is thought due to a TSH stimulation-blocking antibody (TSBAb) which blocks the action of TSH hormone and subsequently brings damage and atrophy to thyroid gland. Approximately 15-20% of patients with Graves' disease had been reported to have spontaneous hypothyroidism resulting from the chronic thyroiditis (Hashimoto's disease). Pathogenesis for chronic thyroiditis following anti-thyroid drug treatment in patients with Graves' disease remains unclear. It has been estimated that chronic thyroiditis or Hashimoto's disease, which occurs following the Graves' disease episode is due to extended immune response in Graves' disease. It includes the immune response to endogenous thyroid antigens, i.e. thyroid peroxidase and thyroglobulin, which may enhance lymphocyte infiltration and finally causes Hashimoto's thyroiditis. We report four cases of chronic thyroiditis (Hashimoto's disease) in patients who have been previously diagnosed with Graves' hyperthyroidism. In three cases, Hashimoto's thyroiditis occurs in 7 to 25 years after the treatment of Grave's disease; while the other case has it only after few months of Grave's disease treatment. The diagnosis of Hashimoto's disease (chronic thyroiditis) was based on clinical manifestation, high TSHs level, positive thyroid peroxidase antibody and thyroglobulin antibody, and supported by positive results of fine needle aspiration biopsy. Moreover, the result of histopathological test has also confirmed the diagnosis in two cases. All cases have been successfully treated by levothyroxine treatment.

  7. Graves opthalmopathy and psychoendocrinopathies

    Directory of Open Access Journals (Sweden)

    Ghanem Asaad

    2010-01-01

    Full Text Available Purpose: To assess the psychiatric and endocrinological changes in patients with Graves ophthalmopathy (GO. Design: A prospective, controlled, University Hospital based study Subjects and Methods: The current study comprised 60 patients diagnosed with GO at Mansoura Ophthalmic Center. Thirty five patients of them with moderate to severe GO formed the study group and twenty five patients with negligible to very mild GO formed the control group in the euthyroid state. The study group was further subdivided based on their predominant clinical signs into a proptosis subgroup and a muscle restriction subgroup . Psychiatric changes were assessed with the Middlesex Hospital Questionnaire (MHQ. Biochemical analyses included serum-free thyroxine and thyroid-stimulating hormone (TSH concentrations, TSH receptor antibody (TRAb activity and anti-thyroglobulin particle agglutination (TGPA and antithyroid microsomal particle agglutination (MCPA. Results: The proptosis group reported significantly higher scores on anxiety, depression, and phobia than the muscle restriction group (P< 0.0001. The proptosis and muscle restriction subgroups reported significantly higher scores on all subscales compared to the control group (P < 0.05. The scale scores of depression and phobia showed a positive correlation with scores of anxiety (P< 0.0001. The serum TRAb activity showed a significant correlation with anxiety, phobia and hysteria (P < 0.0001. Conclusion: The psychiatric aspect of GO should be evaluated during routine follow-up and should be considered when making management decisions. Thyroid specific antibodies may be useful in confirming the diagnosis of GO.

  8. Development of a shell finite element. Application to the thermo-viscoplastic behaviour of a PWR vessel during a severe accident; Developpement d`un element fini coque. Application au comportement thermo-viscoplastique d`une cuve de reacteur nucleaire (REP) en situation d`accident grave

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, V

    1998-10-07

    The aim of this study is to develop a model for the thermo-viscoplastic behaviour of he power water reactor lower head during a severe accident, so as to implement it in codes representing the whole accident progress (scenario codes). So it has to give a precise solution in a short cpu-time. The main loadings are the internal pressure and the strong longitudinal and transverse thermal gradients. To deal with this problem, the idea is to develop a new shell element with variable mechanical parameters with the temperature. This is possible in taking advantage of the properties of the bending center line, called neutral fiber. Besides, this new shell element has the particularity to be able to melt without modifying the initial dimensions of the structure. Then, we have developed a complete program to study the mechanical resistance of the vessel. The visco-plastic behaviour is considered as a loading (so it is placed in the second member of the system to be solved) and represented by a Norton law whose parameters depend on the temperature, the law is integrated explicitly which necessitates the introduction of criteria limiting the time step. The rupture criterion by creep is defined by a damage law whereas the rupture criterion by plasticity is based on the exceeding of the mean limit stress in the thickness. Then the model was validated by comparing the results with those of a Castem 2000 volume mesh (finite element code). Finally the model was coupled with the scenario codes ICARE2 and MAAP4 and tested on two typical severe accidents. The results are very satisfactory both on accuracy and cpu-time execution. (author) 113 refs.

  9. Mass Graves, Landscapes of Terror

    OpenAIRE

    Ferrándiz, Francisco

    2009-01-01

    The recent exhumation of mass graves from the Spanish Civil War and the Post-War years, mostly involving the largely abandoned graves of the Francoist rearguard, have become a central element in contemporary debates about the conflict and the regime following it. In this paper, the complexity and dynamism of this process is analysed, including from political and legal initiatives of great social and media impact to local actions on the ground, at times failed, ephemeral or almost imperceptibl...

  10. Typologie des Accidents Cyclistes

    OpenAIRE

    Amoros, Emmanuelle; BILLOT-GRASSET, Alice; Hours, Martine

    2015-01-01

    L'usage du vélo est en hausse en ville ; cette pratique est encouragée dans le cadre du développement durable et de la lutte contre la sédentarité. Pour accompagner cela, il faut réduire les risques d'accident, et pour ce faire, mieux les connaître. Nous utilisons le Registre des victimes de la circulation routière du Rhône, basé sur les services hospitaliers (dont les urgences) ; il est quasi-exhaustif : env. 1100 blessés à vélo/an versus 120 dans les données officielles. L'ensemble des cycl...

  11. Bicycle accidents.

    Science.gov (United States)

    Lind, M G; Wollin, S

    1986-01-01

    Information concerning 520 bicycle accidents and their victims was obtained from medical records and the victims' replies to questionnaires. The analyzed aspects included risk of injury, completeness of accident registrations by police and in hospitals, types of injuries and influence of the cyclists' age and sex, alcohol, fatigue, hunger, haste, physical disability, purpose of cycling, wearing of protective helmet and other clothing, type and quality of road surface, site of accident (road junctions, separate cycle paths, etc.) and turning manoeuvres.

  12. Immunological aspects of Graves' disease

    NARCIS (Netherlands)

    B.M. van Ouwerkerk (Marcel)

    1986-01-01

    textabstractAssuming an autoimmune interested to know whether apart from restoring the immunologic parameters. Freshly diagnosed hyperthyroid patients with Graves' disease were all similarly treated with MMI 10 mg t.i.d. and when euthyroidism was achieved, with substitution of thyroid hormone. At

  13. Clinical evaluation of Graves ophthalmopathy

    Directory of Open Access Journals (Sweden)

    Janićijević-Petrović Mirjana A.

    2012-01-01

    Full Text Available Introduction. Graves ophthalmopathy is an autoimmune disease, which is the consequence of thyroid dysfunction. Ocular manifestations occur in 50% of patients with Graves disease. The changes occur due to the inflammatory cell infiltration of retrobulbar fat tissue and extraocular muscles. Ultrasonography of eye orbit provides important information about the condition of retrobulbar adipose tissue and the thickness of extraocular muscles. Objective. The aim of our study was to show the clinical significance of orbital ultrasonography in the diagnostics and follow-up of patients with Graves disease. Methods. The authors examined 154 patients with Graves ophthalmopathy at the Clinic of Ophthalmology of the Clinical Centre in Kragujevac during the period 2008–2010. Ophthalmological examination included visual acuity testing (Snellen chart, biomicroscopy and applanation tonometry, direct and indirect ophthalmoscopy, dry eye testing and exophthalmometry (Hertel. Orbital ultrasonography examination and extraorbital muscle measurement was done by ultrasound B-scan. Results. The disease was more frequent in women (79.87% aged from 36–45 years. Most patients had hyperthyreoidism (54.55%. In relation to the duration of the disease, the most frequent clinical signs were bilateral ptosis, conjunctival chemosis and periorbital edema. According to our data the highest number of patients had enlarged medial straight muscle. Conclusion. Graves ophthalmopathy is the most frequent sign of thyroid disease. By orbital ultrasonography we detected extended echogram and measured the thickness of the extraocular muscle. Computerized tomography and magnetic resonance scan were utilized for cases of insufficiently manifested clinical signs of the disease. The advantages of ultrasonography lie in easy handling, patients’ comfort, short time of examination and possibilities of repetition.

  14. Graves' disease associated with histologic Hashimoto's thyroiditis.

    Science.gov (United States)

    Falk, S A; Birken, E A; Ronquillo, A H

    1985-02-01

    The microscopic slides of 16 patients who underwent bilateral subtotal thyroidectomy for hyperthyroid Graves' disease were reviewed and classified into three groups: I, Hashimoto's thyroiditis; II, Graves' disease; and III, both Hashimoto's thyroiditis and Graves' disease. Three patients were classified as group I, 10 as group II, and three as group III. In 38% of the patients with clinical Graves' disease the histologic evidence of Hashimoto's thyroiditis could be found either alone or in combination with histologic evidence of Graves' disease (groups I and III). One patient in group I, four in group II, and three in group III had infiltrative ophthalmopathy (50% of total). Hyperthyroid Graves' disease, Graves' ophthalmopathy, and Hashimoto's thyroiditis can occur all together, in duads, or individually at a specific time in a patient's life.

  15. Accident Statistics

    Data.gov (United States)

    Department of Homeland Security — Accident statistics available on the Coast Guard’s website by state, year, and one variable to obtain tables and/or graphs. Data from reports has been loaded for...

  16. Sports Accidents

    CERN Multimedia

    Kiebel

    1972-01-01

    Le Docteur Kiebel, chirurgien à Genève, est aussi un grand ami de sport et de temps en temps médecin des classes genevoises de ski et également médecin de l'équipe de hockey sur glace de Genève Servette. Il est bien qualifié pour nous parler d'accidents de sport et surtout d'accidents de ski.

  17. Contribution of radio-iodine 131 in the treatment of Grave's Basedow disease in the department of nuclear medicine of Ibn Sina Hospital in Rabat; Apport de l'iode 131 dans le traitement de la maladie de Basedow dans le service de medecine nucleaire de l'hopital Ibn Sina de Rabat

    Energy Technology Data Exchange (ETDEWEB)

    Mbodj, M.; Amjad, I. [Faculte de Medecine de Dakar, Lab. de Biophysique et de Medecine Nucleaire, UCAD, Dakar (Senegal); Guerrouj, H.; Ben Rais, N.A. [Hopital Ibn Sina de Rabat, Service de Medecine Nucleaire, Rabat (Morocco)

    2009-10-15

    One hundred and twenty-nine Grave's Basedow diseases in any gender and variable age patients, coming from several cities of Morocco, were randomized in a study of radio-iodine treatment who took place at the nuclear medicine department of Ibn Sina Hospital (Rabat, Morocco) during the period (from January 2001 to December 2008). The radio-iodine treatment was a first, second or third option and radio-iodine activities delivered varied (from 222 to 555 MBq 6 to 15 mCi) according to the age, the thyroid volume, the degree of hyperthyroidism and socio-economical situation. The high amounts of {sup 131}I were reserved especially to the patients who live far and whose socio-economic level is low with an aim of quickly obtaining an easily controllable state of hypothyroidism by a substitute treatment. The results showed that: (1) 57.36% of patients reverted to euthyroidism (n = 74) with a patient having received two {sup 131}I cures. The second cure was justified by recurrence of hyperthyroidism after the first cure; (2) 34.88% passed in hypothyroidism (n = 45) with three patients having received two cures of {sup 131}I, the second cure was justified by recurrence of hyperthyroidism after the first cure in two patients and by the persistence of the hyperthyroidism after the first cure for the third patient. The average time of passage in hypothyroidism was 4.5 months; (3) 7.76% had remained in hyperthyroidism after the radioactive iodine treatment. Finally, 92.24% of our patients treated by radioactive iodine had passed in euthyroidism or hypothyroidism against 7.76% whose hyperthyroidism had persisted or occurred. (authors)

  18. Raconter Accident nocturne de Patrick Modiano Raconter Accident nocturne de Patrick Modiano

    Directory of Open Access Journals (Sweden)

    Jurate Kaminskas

    2012-10-01

    Full Text Available Modiano affirme que chaque roman marque un pas en avant dans la réalisation de son oeuvre. « J’ai l’impression qu’à chaque livre je me suis débarrassé d’un truc pour essayer d’accéder à d'autres choses », explique-t-il dans un entretien avec Laurence Liban. Qu’en est-il donc pour Accident nocturne ?Modiano affirme que chaque roman marque un pas en avant dans la réalisation de son oeuvre. « J’ai l’impression qu’à chaque livre je me suis débarrassé d’un truc pour essayer d’accéder à autre chose », explique-t-il dans un entretien avec Laurence Liban. Qu’en est-il donc pour Accident nocturne ?

  19. Accidents du travail et mesures de prevention - Annee 2005

    CERN Document Server

    Fassnacht, V

    2006-01-01

    Ce rapport présente les statistiques relatives aux accidents du travail pour l’année 2005 pour les membres du personnel CERN et du personnel entreprise. Il fournit les taux de fréquence et de gravité, la répartition des accidents par cause et par lésion. Ce rapport présente également une synthèse de l’analyse des accidents les plus graves et des recommandations associées.

  20. Dermopathy of Graves' disease: Clinico-pathological correlation.

    Science.gov (United States)

    Reddy, Sagili Vijaya Bhaskar; Gupta, Sushil Kumar; Jain, Manoj

    2012-05-01

    Dermopathy of Graves' disease is a classical, but uncommon extrathyroidal manifestation of Graves' disease. The images of a typical case of dermopathy of Graves' disease are presented along with clinico-pathological correlation.

  1. PREGO (presentation of Graves' orbitopathy) study

    DEFF Research Database (Denmark)

    Perros, Petros; Žarković, Miloš; Azzolini, Claudio

    2015-01-01

    BACKGROUND/AIMS: The epidemiology of Graves' orbitopathy (GO) may be changing. The aim of the study was to identify trends in presentation of GO to tertiary centres and initial management over time. METHODS: Prospective observational study of European Group On Graves' Orbitopathy (EUGOGO) centres...

  2. Biventricular Takotsubo cardiomyopathy in Graves hyperthyroidism.

    Science.gov (United States)

    Perkins, Matthew J; Schachter, David T

    2014-03-01

    Graves hyperthyroidism is commonly seen in clinical practice and Takotsubo stress cardiomyopathy is an increasingly recognized cardiac complication of physical or emotional stress. We report the rare case of a patient with Graves hyperthyroidism that was complicated by severe biventricular takotsubo cardiomyopathy, which was demonstrated on heart catheterization. After appropriate pharmacologic treatment of her hyperthyroidism, she had complete resolution of her cardiomyopathy.

  3. Organic chemistry and radiochemistry: study of chemical interactions between iodine and paint of French nuclear reactor in a severe accident situation; Chimie organique et radiochimie. Etude des interactions chimiques iode-peinture dans un reacteur nucleaire (de type R.E.P.) en situation d'accident grave

    Energy Technology Data Exchange (ETDEWEB)

    Aujollet, Y. [Direction Generale de la Surete Nucleaire et de la Radioprotection, 75 - Paris (France)

    2005-01-01

    In Phebus (French in pile facility; PWR scale 1/5000) experiments, performed by the Institut de Radioprotection et de Surete Nucleaire, few quantities of organic iodides were registered after interaction between iodine and reactor containment paint. This study concerns all mechanisms of chemical reactions between iodine and the polymer of the paint in order to estimate the organic iodides released from the paint. At first, all the paint components had been identified. Several models of chemical sites of the polymer were synthesized and tested with iodine in different conditions of temperature and radiation. These experiments showed interactions between iodine and secondary or tertiary amines by charge transfer. In few cases, the complex of tertiary amines creates oxidation reactions. (author)

  4. Accident: Reminder

    CERN Document Server

    2003-01-01

    There is no left turn to Point 1 from the customs, direction CERN. A terrible accident happened last week on the Route de Meyrin just outside Entrance B because traffic regulations were not respected. You are reminded that when travelling from the customs, direction CERN, turning left to Point 1 is forbidden. Access to Point 1 from the customs is only via entering CERN, going down to the roundabout and coming back up to the traffic lights at Entrance B

  5. [Differential diagnosis of Graves' orbitopathy. Case report].

    Science.gov (United States)

    Erdei, Annamária; Steiber, Zita; Gazdag, Annamária; Bodor, Miklós; Berta, Eszter; Szász, Róbert; Szántó, Antónia; Ujhelyi, Bernadett; Barna, Sándor; Berényi, Ervin; Nagy, V Endre

    2016-02-21

    Graves' orbitopathy is the extrathyroidal manifestation of Graves' disease, which is the most common cause of exophthalmos. As eye symptoms usually coincide with the development of thyrotoxicosis, the diagnosis of the disease is rarely difficult. The aim of the authors was to summarize the differential diagnosis of Graves' orbitopathy based on literature review and presentation of their own four problematic cases on this topic. They conclude that symptoms similar to endocrine orbitopathy are present in other disorders. Endocrinologists need to be aware of these other conditions to avoid treatment failures.

  6. Mass Graves, Landscapes of Terror

    Directory of Open Access Journals (Sweden)

    Ferrándiz, Francisco

    2009-06-01

    Full Text Available The recent exhumation of mass graves from the Spanish Civil War and the Post-War years, mostly involving the largely abandoned graves of the Francoist rearguard, have become a central element in contemporary debates about the conflict and the regime following it. In this paper, the complexity and dynamism of this process is analysed, including from political and legal initiatives of great social and media impact to local actions on the ground, at times failed, ephemeral or almost imperceptible, but no less crucial. From the point of view of many of the people involved in the pro-exhumation associations, opening up the graves is part of a basic exercise in justice and ‘dignification’, showing the scope and systematic nature of repression while reverting the ‘infrahuman’ disposition of the executed corpses, a feeling crystallised in the common expression ‘thrown’ or ‘buried like dogs’, used very often to justify the need of carrying out exhumations. Politics of dignification and ‘rehumanization’ of these ‘incorrectly’ buried bodies are incorporating, in the last few months, elements drawn from international law, such as the concept of ‘crimes against humanity’.

    Las exhumaciones de fosas comunes de la Guerra Civil española y la posguerra de la última década, muy especialmente de fosas abandonadas de la retaguardia franquista, se han colocado en un lugar central de los debates contemporáneos sobre la naturaleza y alcance de la contienda y el régimen que surgió de ella. En este artículo, se analiza la complejidad y dinamismo del proceso, que incluye desde iniciativas políticas y judiciales de enorme proyección pública y mediática, como la Ley de la Memoria o el controvertido auto de Garzón sobre los crímenes del franquismo, hasta acciones locales a veces fallidas, imperceptibles o efímeras, pero no menos cruciales. Desde el punto de vista de muchos de los actores sociales implicados en las exhumaciones

  7. Pneumonia grave por "Chlamydia psittaci"

    Directory of Open Access Journals (Sweden)

    MOSCHIONI CRISTIANE

    2001-01-01

    Full Text Available A psitacose, também conhecida como ornitose, é causada pela Chlamydia psittaci; caracteriza-se por doença de início insidioso, sintomas brandos e inespecíficos, lembrando infecção de vias aéreas superiores. Acomete principalmente o pulmão, sendo raramente doença sistêmica e fatal. Descreve-se um caso raro de pneumonia por Chlamydia psittaci que evoluiu para insuficiência respiratória aguda, necessitando de ventilação mecânica. Destaca-se a importância em considerar o diagnóstico, especialmente em casos de pneumonia comunitária que evolui de modo insatisfatório, que não responde à terapia antimicrobiana e cuja epidemiologia é positiva para exposição às aves. O diagnóstico precoce é fundamental devido à excelente resposta terapêutica. O diagnóstico tardio pode levar a curso grave e fatal da doença.

  8. Orbital Volumetry in Graves' Orbitopathy

    DEFF Research Database (Denmark)

    Al-Bakri, Moug; Rasmussen, Åse Krogh; Thomsen, Carsten

    2014-01-01

    .6 cm(3) in controls, 8.7 ± 8.0 cm(3) in GO without DON, and 9.4 ± 3.1 cm(3) in GO with DON. The muscle and fat volumes were higher in patients with GO than in controls (P orbits with and without DON were not significantly different. The volume of the optic nerve were...... similar in the 3 groups. The number of apical, coronal 2 mm thick slices with no fat was 2.9 ± 0.9 in normal orbits, it was 4.1 ± 1.0 in GO orbits without DON and 5.3 ± 0.8 in GO orbits with DON (P = 0.007). Conclusion. Apical muscle enlargement may be more important than orbital fat enlargement......Purpose. We wanted to investigate the relative significance of fat and muscle enlargement in the development of dysthyroid optic neuropathy (DON) in Graves' orbitopathy (GO). Methods. Preoperative coronal CT scans of 13 patients with and without DON who subsequently underwent orbital decompression...

  9. Self-reported accidents

    DEFF Research Database (Denmark)

    Møller, Katrine Meltofte; Andersen, Camilla Sloth

    2016-01-01

    The main idea behind the self-reporting of accidents is to ask people about their traffic accidents and gain knowledge on these accidents without relying on the official records kept by police and/or hospitals.......The main idea behind the self-reporting of accidents is to ask people about their traffic accidents and gain knowledge on these accidents without relying on the official records kept by police and/or hospitals....

  10. Accidents corporels de la circulation routière liés à l'exercice d'une profession. Etude au sein de la cohorte Gazel

    OpenAIRE

    Chiron, M; Lafont, S; Bernard, M; CHASTANG, JF; Zins, M; Lagarde, E

    2005-01-01

    On observe les accidents corporels de la route survenus aux membres de la cohorte Gazel entre 1989 et 2000, en distinguant les accidents « de mission » (accidents du travail proprement dits), de trajet domicile-travail et lors d'un déplacement privé. On calcule les incidences pour ces trois types d'accidents. Les accidents de mission sont les moins graves, et concernent surtout les hommes. Les accidents de trajet concernent surtout les femmes. On recherche ensuite les facteurs de risque de ch...

  11. Les accidents de la route liés à une activité professionnelle. In: Le véritable enjeu de l'insécurité routière : la victime

    OpenAIRE

    Charbotel, B.

    2001-01-01

    Deux types d'accidents de la route sont liés au travail : les accidents de trajet entre le domicile et le travail et les accidents survenant en mission pour l'employeur. Les accidents de la route en mission sont, dans de nombreux pays, la première cause d'accident mortel du travail (de 20 a 40 % des accidents du travail mortels). En France, près de 40 % des accidents du travail mortels sont des accidents de la route, et le taux de 60 % des accidents mortels est atteint si l'on comptabilise le...

  12. [Neonatal hyperthyroidism and maternal Graves disease].

    Science.gov (United States)

    Ben Ameur, K; Chioukh, F Z; Marmouch, H; Ben Hamida, H; Bizid, M; Monastiri, K

    2015-04-01

    The onset of Graves disease during pregnancy exposes the neonate to the risk of hyperthyroidism. The newborn must be monitored and treatment modalities known to ensure early treatment of the newborn. We report on the case of an infant born at term of a mother with Graves disease discovered during pregnancy. He was asymptomatic during the first days of life, before declaring the disease. Neonatal hyperthyroidism was confirmed by hormonal assays. Hyperthyroidism was treated with antithyroid drugs and propranolol with a satisfactory clinical and biological course. Neonatal hyperthyroidism should be systematically sought in infants born to a mother with Graves disease. The absence of clinical signs during the first days of life does not exclude the diagnosis. The duration of monitoring should be decided according to the results of the first hormonal balance tests.

  13. Bilateral carpal tunnel syndrome in Graves' disease.

    Science.gov (United States)

    Manganelli, P; Pavesi, G; Salaffi, F

    1987-01-01

    Carpal tunnel syndrome (CTS) may be associated with endocrinopathies, such as hypothyroidism and acromegaly. A direct relationship between CTS and hyperthyroidism has recently been suggested. We now report a case in which bilateral CTS developed after treatment of Graves' disease, thus, questioning the possibility of a relationship between these two disease processes.

  14. Diagnosis and treatment of Graves disease.

    Science.gov (United States)

    Streetman, Darcie D; Khanderia, Ujjaini

    2003-01-01

    To review the etiology, diagnosis, and clinical presentation of Graves disease and provide an overview of the standard and adjunctive treatments. Specifically, antithyroid drugs, beta-blockers, inorganic iodide, lithium, and radioactive iodine are discussed, focusing on current controversies. Primary articles were identified through a MEDLINE search (1966-July 2000). Key word searches included beta-blockers, Graves disease, inorganic iodide, lithium, methimazole, and propylthiouracil. Additional articles from these sources and endocrinology textbooks were also identified. We agreed to include articles that would highlight the most relevant points, as well as current areas of controversy. Graves disease is the most common cause of hyperthyroidism. The 3 main treatment options for patients with Graves hyperthyroidism include antithyroid drugs, radioactive iodine, and surgery. Although the antithyroid drugs propylthiouracil (PTU) and methimazole (MMI) have similar efficacy, there are situations when 1 agent is preferred. MMI has a longer half-life than PTU, allowing once-daily dosing that can improve patient adherence to treatment. PTU has historically been the drug of choice for treating pregnant and breast-feeding women because of its limited transfer into the placenta and breast milk. Adjuvant therapies for Graves disease include beta-blockers, inorganic iodide, and lithium. beta-Blockers are used to decrease the symptoms of hyperthyroidism. Inorganic iodide is primarily used to prepare patients for thyroid surgery because of its ability to decrease the vascularity of the thyroid gland. Lithium, which acts in a manner similar to iodine, is not routinely used due to its transient effect and the risk of potentially serious adverse effects. In the US, radioiodine therapy has become the preferred treatment for adults with Graves disease. It is easy to administer, safe, effective, and more affordable than long-term treatment with antithyroid drugs. Hypothyroidism is an

  15. ECONOMIC COSTS ASSOCIATED WITH MOTORBIKE ACCIDENTS IN KATHMANDU, NEPAL

    Directory of Open Access Journals (Sweden)

    Diksha Sapkota

    2016-12-01

    Full Text Available Background: Road traffic accidents, considered as global tragedies, are in increasing trend however, the safety situation is very severe in developing countries incurring substantial amount of human, economic and social costs. Motorcycle crashes, the commonest form, occur mostly on economically active population. However, there is limited coverage of studies on economic burden of motorcycle crashes. This study aims to estimate the total cost and DALYs lost due to motorbike accidents among victims of Kathmandu Valley.Materials and Methods: Retrospective cross-sectional study was conducted among the patients having history of motorbike accidents within past twelve months and at least 3 months from the date of data collection. Interview was conducted using proforma among 100 victims of accidents and their care giver in case of death from November 15, 2014 to May 15, 2015. Cost estimation of motorbike accident was done based on human capital approach. Data collection tool was pretested and collected data were analyzed by SPSS and Microsoft excel. Results: Males (79% belonging to the economically productive age group shared the highest proportion among total accidents victims. Most common reason for accidents was reported to be poor road condition (41%. Indirect cost was found to be significantly higher than direct costs highlighting its negative impact on economy of family and nation due to productivity loss. Total Disability Adjusted Life Years (DALYs lost per person was found to be 490 years and national estimation showed large burden of motorbike accidents due to huge DALY loss.Conclusions: For low resource countries like Nepal, high economic costs of motorbike accidents can pose additional burden to the fragile health system. These accidents can be prevented, and their consequences can be alleviated. There is an urgent need for reinforcement of appropriate interventions and legislation to decrease the magnitude of it and its associated grave

  16. Accidents du travail et mesures de prévention Année 2003

    CERN Document Server

    Kerhoas, A

    2004-01-01

    Ce rapport présente les statistiques relatives aux accidents du travail pour l’année 2003 pour les membres du personnel CERN et du personnel entreprise. Il fournit les taux de fréquence et de gravité, la répartition des accidents par cause et par lésion. Ce rapport présente également une synthèse de l’analyse des accidents les plus graves et des recommandations associées.

  17. Accidents du travail et mesures de prévention - Année 2004

    CERN Document Server

    Avedian, E

    2005-01-01

    Ce rapport présente les statistiques relatives aux accidents du travail pour l’année 2004 pour les membres du personnel CERN et du personnel entreprise. Il fournit les taux de fréquence et de gravité, la répartition des accidents par cause et par lésion. Ce rapport présente également une synthèse de l’analyse des accidents les plus graves et des recommandations associées.

  18. Accidents du travail et mesures de prévention -Année 2006

    CERN Document Server

    Fassnacht, Véronique

    2007-01-01

    Ce rapport présente les statistiques relatives aux accidents du travail pour l’année 2006 pour les membres du personnel CERN et du personnel entreprise. Il fournit les taux de fréquence et de gravité, la répartition des accidents par cause et par lésion. Ce rapport présente également une synthèse de l’analyse des accidents les plus graves et des recommandations associées.

  19. Graves-Basedow disease and potential risk factors

    Directory of Open Access Journals (Sweden)

    Živanović Dušica

    2008-01-01

    Full Text Available Background/Aim. Graves-Basedow disease is a common multifactorial genetic syndrome, which is determined by several genes and environmental factors. The aim of the present study was to investigate the presence of risk factors for developing Graves-Basedow disease between the groups of individuals with and without Graves-Basedow disease, and to compare the presence of risk factors between the affected individuals with or without positive family history for Graves- Basedow disease. Methods. This cross-sectional study was conducted in Ćuprija (central Serbia during a period from December 2001 to April 2002. The case group comprised 132 individuals diagnosed with Graves-Basedow disease. The control group comprised 130 subjects without any of endocrine diseases. All participants were interviewed at the Medical Center Ćuprija using structural questionnaire. Data were collected on basic demographic characteristics, exposure to various chemical and physical agents, stress, smoking and family history of Graves-Basedow disease. In statistical analysis chi-square test was used. Results. The individuals with Graves-Basedow disease were statistically significantly older (above 50 (p = 0.020, exposed to stress (p = 0.024 and to physical agents (p = 0.031, and had significantly (p = 0.000 more relatives with Graves-Basedow disease than those without the disease. Among the affected individuals with positive family history of Graves-Basedow disease the number of women was significantly higher (p = 0.000, than the affected individuals without positive family history of Graves- Basedow disease. Conclusion. In our study, as in many other, gender, age, positive family history of Graves-Basedow disease and exposure to physical agents were identified as potential risk factors for the increased incidence of Graves- Basedow disease. Different risk factors are probably responsible for developing Graves-Basedow disease among the affected individuals with or without

  20. Tratamiento de la enfermedad de Graves Basedow

    Directory of Open Access Journals (Sweden)

    Hernando Vargas-Uricoechea

    2014-05-01

    Full Text Available Se realizó una revisión narrativa rigurosa de la literatura inglesa y en español sobre diferentes aspectos de la Enfermedad de Graves-Basedow e hipertiroidismo. Esta patología –parte de la llamada “enfermedad tiroidea autoinmune”- se produce como consecuencia de la presencia de anticuerpos circulantes que se unen y activan al receptor de tirotropina, desencadenándose generalmente el hipertiroidismo en asociación con un estrés agudo. En este artículo actualizamos tanto el manejo de hipertiroidismo como el de problemas especiales con el que puede estar asociado. La fisiopatología y el diagnóstico de la Enfermedad de Graves-Basedow son motivo de otra publicación.

  1. Diagnosis and classification of Graves' disease.

    Science.gov (United States)

    Menconi, Francesca; Marcocci, Claudio; Marinò, Michele

    2014-01-01

    Graves' disease (GD) is an autoimmune disorder involving the thyroid gland, typically characterized by the presence of circulating autoantibodies that bind to and stimulate the thyroid hormone receptor (TSHR), resulting in hyperthyroidism and goiter. Organs other than the thyroid can also be affected, leading to the extrathyroidal manifestations of GD, namely Graves' ophthalmopathy, which is observed in ~50% of patients, and Graves' dermopathy and acropachy, which are quite rare. Presumably, the extrathyroidal manifestations of GD are due to autoimmunity against antigens common to the thyroid and other affected organs. Although its exact etiology remains to be completely understood, GD is believed to result from a complex interaction between genetic susceptibility and environmental factors. Clinically, GD is characterized by the manifestations of thyrotoxicosis as well as by its extrathyroidal features when present, the latter making the diagnosis almost unmistakable. In the absence of ophthalmopathy, the diagnosis is generally based on the association of hyperthyroidism and usually diffuse goiter confirmed with serum anti-TSHR autoantibodies (TRAbs). Hyperthyroidism is generally treated with anti-thyroid drugs, but a common long term treatment strategy in patients relapsing after a course of anti-thyroid drugs (60-70%), implies the use of radioactive iodine or surgery.

  2. Visualization of Traffic Accidents

    Science.gov (United States)

    Wang, Jie; Shen, Yuzhong; Khattak, Asad

    2010-01-01

    Traffic accidents have tremendous impact on society. Annually approximately 6.4 million vehicle accidents are reported by police in the US and nearly half of them result in catastrophic injuries. Visualizations of traffic accidents using geographic information systems (GIS) greatly facilitate handling and analysis of traffic accidents in many aspects. Environmental Systems Research Institute (ESRI), Inc. is the world leader in GIS research and development. ArcGIS, a software package developed by ESRI, has the capabilities to display events associated with a road network, such as accident locations, and pavement quality. But when event locations related to a road network are processed, the existing algorithm used by ArcGIS does not utilize all the information related to the routes of the road network and produces erroneous visualization results of event locations. This software bug causes serious problems for applications in which accurate location information is critical for emergency responses, such as traffic accidents. This paper aims to address this problem and proposes an improved method that utilizes all relevant information of traffic accidents, namely, route number, direction, and mile post, and extracts correct event locations for accurate traffic accident visualization and analysis. The proposed method generates a new shape file for traffic accidents and displays them on top of the existing road network in ArcGIS. Visualization of traffic accidents along Hampton Roads Bridge Tunnel is included to demonstrate the effectiveness of the proposed method.

  3. Modeling of the thermal transfer inside a porous environment: application to nuclear reactors in accident situation; Modelisation du transfert thermique dans un milieu poreux: application aux reacteurs nucleaires en situation accidentelle

    Energy Technology Data Exchange (ETDEWEB)

    Rubiolo, P.R

    2000-03-01

    The purpose of this report is to simulate heat exchanges occurring by conduction, by convection and by radiating in a porous medium made up of opaque particles in a semi-transparent fluid. Usually the determination of the macroscopic equations is based on homogenization techniques, but in the case of a major accident, the complexity of the problem is so overwhelming that semi-empirical methods are used to determine macroscopic coefficients. The author develops a new method to determine these coefficients, this method is based on the calculation of different tensors: the equivalent conductivity tensor, the radiative conductivity tensor, the thermal conductivity tensor and the heat exchange coefficient (h{sub sf}) between the solid phase and the fluid one. The first chapter briefly describes energy, impulse and mass balances. In the case of the energy balance the solid phase is not supposed to be in thermal equilibrium with the liquid phase. The second chapter presents an application of the porous media method to a one-dimensional and stationary problem, this application to a simple problem gives an idea of the performance of the method. The model allowing the calculation of h{sub sf} is developed, it is a wide range model. The second chapter ends with the presentation of the model allowing the computing of the effective conductivity of fuel rods. A comparison between results given by this new method and other numeric calculations or experimental data coming from benchmarks is presented in the third chapter. This chapter ends with the simulation of a reactor core in accidental situation, 2 cases are presented: with and without the presence of water steam. (A.C.)

  4. Graves' disease associated with alopecia areata developing after Hashimoto's thyroiditis.

    Science.gov (United States)

    Aşık, Mehmet; Binnetoğlu, Emine; Şen, Hacer; Tekeli, Zeliha; Uysal, Fatma; Ukinç, Kubilay

    2013-01-01

    Graves' disease and Hashimoto's thyroiditis are the most common autoimmune thyroid diseases. Hypothyroidism can develop in patients with Graves' disease, either spontaneously or as a result of radioactive iodine therapy or surgery. However, it is rare for patients with Hashimoto's thyroiditis to subsequently develop Graves' disease. We report a case of alopecia areata associated with Graves' disease in a 41-year-old woman who had previously been diagnosed with Hashimoto's disease. Alopecia areata is an autoimmune disease associated with other autoimmune diseases such as thyroid disorders, anemia, and other skin disorders.

  5. Tratamiento de la osteoporosis grave con teriparatide

    Directory of Open Access Journals (Sweden)

    Marcelo A. Sarli

    2013-10-01

    Full Text Available El objetivo de este trabajo retrospectivo fue evaluar el tratamiento de la osteoporosis grave con teriparatide (PTH y comparar nuestros resultados con los publicados en la literatura médica. Se incluyeron cuarenta y seis pacientes, cuarenta y dos mujeres y cuatro varones, edad: 69.15 ± 9.43 años. Seis eran vírgenes de tratamiento y cuarenta tratados previamente con bisfosfonatos. Treinta y dos pacientes habían tenido 93 fracturas de las cuales 86 vertebrales. Cuarenta y seis recibieron PTH 6 meses, 29 pacientes durante 12 meses y 20 completaron los 18 meses sugeridos. La densidad mineral ósea (DMO de columna lumbar aumentó significativamente desde el primer control a los 6 meses (p < 0.0001. La DMO de cuello de fémur alcanzó un incremento significativo al final del tratamiento (p = 0.002. La osteocalcina aumentó significativamente al mes, seguido por el ß crosslaps (beta-CTx, prueba en suero al tercer mes y la fosfatasa alcalina ósea, regresando los marcadores de recambio óseo a niveles basales a los 18 meses. Las calcemias y las calciurias no se modificaron significativamente, pero 8 pacientes tuvieron hipercalcemias leves y tres hipercalciurias asintomáticas. El tratamiento fue bien tolerado y no se registraron efectos adversos graves que requirieran suspender el tratamiento. En conclusión, la PTH es una alternativa útil y segura para el tratamiento de la osteoporosis grave. Nuestros resultados concuerdan con los previamente publicados en la literatura médica.

  6. Laser accidents: Being Prepared

    Energy Technology Data Exchange (ETDEWEB)

    Barat, K

    2003-01-24

    The goal of the Laser Safety Officer and any laser safety program is to prevent a laser accident from occurring, in particular an injury to a person's eyes. Most laser safety courses talk about laser accidents, causes, and types of injury. The purpose of this presentation is to present a plan for safety offices and users to follow in case of accident or injury from laser radiation.

  7. Tratamiento de la enfermedad de Graves Basedow

    OpenAIRE

    Hernando Vargas-Uricoechea; Carlos Hernán Sierra-Torres; Ivonne Alejandra Meza-Cabrera

    2014-01-01

    Se realizó una revisión narrativa rigurosa de la literatura inglesa y en español sobre diferentes aspectos de la Enfermedad de Graves-Basedow e hipertiroidismo. Esta patología –parte de la llamada “enfermedad tiroidea autoinmune”- se produce como consecuencia de la presencia de anticuerpos circulantes que se unen y activan al receptor de tirotropina, desencadenándose generalmente el hipertiroidismo en asociación con un estrés agudo. En este artículo actualizamos tanto el manejo de hipertiroid...

  8. [Accidents with the "paraglider"].

    Science.gov (United States)

    Lang, T H; Dengg, C; Gabl, M

    1988-09-01

    With a collective of 46 patients we show the details and kinds of accidents caused by paragliding. The base for the casuistry of the accidents was a questionnaire which was answered by most of the injured persons. These were questions about the theoretical and practical training, the course of the flight during the different phases, and the subjective point of view of the course of the accident. The patterns of the injuries showed a high incidence of injuries of the spinal column and high risks for the ankles. At the end, we give some advice how to prevent these accidents.

  9. Accidents (FARS) (National)

    Data.gov (United States)

    Department of Transportation — Accident - (1975-current): This data file (NTAD) contains information about crash characteristics and environmental conditions at the time of the crash. There is one...

  10. PSA LEVEL 3 DAN IMPLEMENTASINYA PADA KAJIAN KESELAMATAN PWR

    Directory of Open Access Journals (Sweden)

    Pande Made Udiyani

    2015-03-01

    Full Text Available Kajian keselamatan PLTN menggunakan metodologi kajian probabilistik sangat penting selain kajian deterministik. Metodologi kajian menggunakan Probabilistic Safety Assessment (PSA Level 3 diperlukan terutama untuk estimasi kecelakaan parah atau kecelakaan luar dasar desain PLTN. Metode ini banyak dilakukan setelah kejadian kecelakaan Fukushima. Dalam penelitian ini dilakukan implementasi PSA Level 3 pada kajian keselamatan PWR, postulasi kecelakan luar dasar desain PWR AP-1000 dan disimulasikan di contoh tapak Bangka Barat. Rangkaian perhitungan yang dilakukan adalah: menghitung suku sumber dari kegagalan teras yang terjadi, pemodelan kondisi meteorologi tapak dan lingkungan, pemodelan jalur paparan, analisis dispersi radionuklida dan transportasi fenomena di lingkungan, analisis deposisi radionuklida, analisis dosis radiasi, analisis perlindungan & mitigasi, dan analisis risiko. Kajian menggunakan rangkaian subsistem pada perangkat lunak PC Cosyma. Hasil penelitian membuktikan bahwa implementasi metode kajian keselamatan PSA Level 3 sangat efektif dan komprehensif terhadap estimasi dampak, konsekuensi, risiko, kesiapsiagaan kedaruratan nuklir (nuclear emergency preparedness, dan manajemen kecelakaan reaktor terutama untuk kecelakaan parah atau kecelakaan luar dasar desain PLTN. Hasil kajian dapat digunakan sebagai umpan balik untuk kajian keselamatan PSA Level 1 dan PSA Level 2. Kata kunci: PSA level 3, kecelakaan, PWR   Reactor safety assessment of nuclear power plants using probabilistic assessment methodology is most important in addition to the deterministic assessment. The methodology of Level 3 Probabilistic Safety Assessment (PSA is especially required to estimate severe accident or beyond design basis accidents of nuclear power plants. This method is carried out after the Fukushima accident. In this research, the postulations beyond design basis accidentsof PWR AP - 1000 would be taken, and simulated at West Bangka sample site. The

  11. Communication and industrial accidents

    NARCIS (Netherlands)

    As, Sicco van

    2001-01-01

    This paper deals with the influence of organizational communication on safety. Accidents are actually caused by individual mistakes. However the underlying causes of accidents are often organizational. As a link between these two levels - the organizational failures and mistakes - I suggest the conc

  12. Accidents - personal factors

    Energy Technology Data Exchange (ETDEWEB)

    Zaitsev, S.L.; Tsygankov, A.V.

    1982-03-01

    This paper evaluates influence of selected personal factors on accident rate in underground coal mines in the USSR. Investigations show that so-called organizational factors cause from 80 to 85% of all accidents. About 70% of the organizational factors is associated with social, personal and economic features of personnel. Selected results of the investigations carried out in Donbass mines are discussed. Causes of miner dissatisfaction are reviewed: 14% is caused by unsatisfactory working conditions, 21% by repeated machine failures, 16% by forced labor during days off, 14% by unsatisfactory material supply, 16% by hard physical labor, 19% by other reasons. About 25% of miners injured during work accidents are characterized as highly professionally qualified with automatic reactions, and about 41% by medium qualifications. About 60% of accidents is caused by miners with less than a 3 year period of service. About 15% of accidents occurs during the first month after a miner has returned from a leave. More than 30% of accidents occurs on the first work day after a day or days off. Distribution of accidents is also presented: 19% of accidents occurs during the first 2 hours of a shift, 36% from the second to the fourth hour, and 45% occurs after the fourth hour and before the shift ends.

  13. Accident investigation and analysis

    NARCIS (Netherlands)

    Kampen, J. van; Drupsteen, L.

    2013-01-01

    Many organisations and companies take extensive proactive measures to identify, evaluate and reduce occupational risks. However, despite these efforts things still go wrong and unintended events occur. After a major incident or accident, conducting an accident investigation is generally the next ste

  14. 75 FR 65030 - Native American Graves Protection and Repatriation Review Committee: Nomination Solicitation

    Science.gov (United States)

    2010-10-21

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Nomination Solicitation AGENCY: National Park Service, Interior. ACTION: Native American Graves Protection and... nominations for two members of the Native American Graves Protection and Repatriation Review Committee....

  15. 75 FR 13140 - Native American Graves Protection and Repatriation Review Committee: Nomination Solicitation

    Science.gov (United States)

    2010-03-18

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Nomination Solicitation AGENCY: National Park Service, Interior. ACTION: Native American Graves Protection and... nominations for one member of the Native American Graves Protection and Repatriation Review Committee....

  16. Graves' orbitopathy as a rare disease in Europe

    DEFF Research Database (Denmark)

    Perros, Petros; Hegedüs, L; Bartalena, L.

    2017-01-01

    qualify as rare. Recent published data on the incidence of GO and Graves' hyperthyroidism in Europe were used to estimate the prevalence of GO. The position statement was developed by a series of reviews of drafts and electronic discussions by members of the European Group on Graves' Orbitopathy...

  17. Current insights into animal models of Graves' disease and orbitopathy.

    Science.gov (United States)

    Wiesweg, B; Johnson, K T M; Eckstein, A K; Berchner-Pfannschmidt, U

    2013-08-01

    Graves' disease (GD) is a systemic autoimmune disease that is characterized by hyperthyroidism, orbitopathy and in rare cases dermopathy. Graves' orbitopathy (GO) is an inflammatory disease of eye and orbit which occurs in about 30-60% of patients. Hyperthyroidism occurs due to the presence of stimulating TSHR-autoantibodies (TRAbs) leading to increased serum levels of thyroid hormones. Attempts to induce Graves' disease in mice by immunization against the hTSHR or its variants have resulted in production of TRAbs that stimulate thyroid follicular cells to increase thyroid hormone secretion. Graves' like orbital changes, such as inflammation, adipogenesis and muscle fibrosis are more difficult to induce. In this review we summarize different methods used to induce murine Graves'-like disease and their impact on murine orbits.

  18. Outcome of Very Long-Term Treatment with Antithyroid Drugs in Graves' Hyperthyroidism Associated with Graves' Orbitopathy

    NARCIS (Netherlands)

    L. Elbers; M. Mourits; W. Wiersinga

    2011-01-01

    Background: It is still debated which treatment modality for Graves' hyperthyroidism (GH) is most appropriate when Graves' orbitopathy (GO) is present. The preference in our center has been always to continue antithyroid drugs for GH (as the block-and-replace [B-R] regimen) until all medical and/or

  19. Radiation therapy of Graves' ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kawamura, Toshiki; Koga, Sukehiko; Anno, Hirofumi; Komai, Satoshi (Fujita-Gakuen Health Univ., Toyoake, Aichi (Japan))

    1992-01-01

    During the decade from 1978 to 1987, 20 patients with Graves' ophthalmopathy were treated with irradiation of 2000 cGy to the orbital tissue. We examined the effects of the therapy on 17 such patients. Exophthalmos tended to decrease. When the degree of deviation of the exophthalmic eye was small, the effect of therapy tended to be better than when it was large. Two cases that showed an increase in retrobulbar fatty tissue without thickening of the extraocular muscles did not respond as well as those that had thickening of the extraocular muscles. Diplopia tended to improve both subjectively and objectively. Ocular movement improved in 11 of the 17 patients. There were no serious radiation injuries after the radiation therapy, except for some transient swelling of the eyelid. (author).

  20. Radiologia contrastada do timo na miastenia grave

    Directory of Open Access Journals (Sweden)

    José Lamartine de Assis

    1964-03-01

    Full Text Available Foram estudados 20 casos de miastenia grave mediante exame radiológico simples para evidenciar a persistência ou hipertrofia do timo e estudar, comparativamente, os resultados dêste método propedêutico com o uso do enfisema do mediastino seguido de pneumografia e/ou planigrafia. Com tal procedimento foi possível mostrar, em 18 dos casos, a persistência ou hipertrofia do timo. Em alguns casos foram analisados os diversos aspectos radiológicos do timo em suas relações com as medidas terapêuticas, adotadas em particular com o uso do ACTH, radioterapia e/ou timectomia; neste particular, os autores não puderam tirar conclusões definitivas por ser pequeno o número de casos estudados.

  1. Persistence of airline accidents.

    Science.gov (United States)

    Barros, Carlos Pestana; Faria, Joao Ricardo; Gil-Alana, Luis Alberiko

    2010-10-01

    This paper expands on air travel accident research by examining the relationship between air travel accidents and airline traffic or volume in the period from 1927-2006. The theoretical model is based on a representative airline company that aims to maximise its profits, and it utilises a fractional integration approach in order to determine whether there is a persistent pattern over time with respect to air accidents and air traffic. Furthermore, the paper analyses how airline accidents are related to traffic using a fractional cointegration approach. It finds that airline accidents are persistent and that a (non-stationary) fractional cointegration relationship exists between total airline accidents and airline passengers, airline miles and airline revenues, with shocks that affect the long-run equilibrium disappearing in the very long term. Moreover, this relation is negative, which might be due to the fact that air travel is becoming safer and there is greater competition in the airline industry. Policy implications are derived for countering accident events, based on competition and regulation. © 2010 The Author(s). Journal compilation © Overseas Development Institute, 2010.

  2. Accidents with sulfuric acid

    Directory of Open Access Journals (Sweden)

    Rajković Miloš B.

    2006-01-01

    Full Text Available Sulfuric acid is an important industrial and strategic raw material, the production of which is developing on all continents, in many factories in the world and with an annual production of over 160 million tons. On the other hand, the production, transport and usage are very dangerous and demand measures of precaution because the consequences could be catastrophic, and not only at the local level where the accident would happen. Accidents that have been publicly recorded during the last eighteen years (from 1988 till the beginning of 2006 are analyzed in this paper. It is very alarming data that, according to all the recorded accidents, over 1.6 million tons of sulfuric acid were exuded. Although water transport is the safest (only 16.38% of the total amount of accidents in that way 98.88% of the total amount of sulfuric acid was exuded into the environment. Human factor was the common factor in all the accidents, whether there was enough control of the production process, of reservoirs or transportation tanks or the transport was done by inadequate (old tanks, or the accidents arose from human factor (inadequate speed, lock of caution etc. The fact is that huge energy, sacrifice and courage were involved in the recovery from accidents where rescue teams and fire brigades showed great courage to prevent real environmental catastrophes and very often they lost their lives during the events. So, the phrase that sulfuric acid is a real "environmental bomb" has become clearer.

  3. Radiotherapy in the management of Graves` ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Sakata, Koh-ichi; Hareyama, Masato; Oouchi, Atsushi; Shidou, Mitsuo; Nagakura, Hisayasu; Morita, Kazuo; Osanai, Hajime; Ohtsuka, Kenji; Hinoda, Yuji [Sapporo Medical Univ. (Japan). School of Medicine

    1998-06-01

    To report the results of radiotherapy for patients with failure, adverse reactions or relative contraindications to the use of steroids or immunosuppressants, by using newly developed quantitative indexes. Fourteen female and six male patients with Graves` ophthalmopathy were treated with radiotherapy between 1989 and 1996. Prior to radiotherapy, eight patients received treatment with prednisone, four received immunosuppressants and four received a combination of both. Four patients with contraindications to steroids were initially managed with radiotherapy. Most of the patients received a dose of 24-28 Gy in 2 Gy fractions. We used the newly developed motility limitation index to assess extraocular motility. Treatment was well tolerated. There have been no late complications. All 12 patients with soft tissue signs such as edema, irritation, tearing and pain were improved. Proptosis did not improve or improved only slightly, 3 mm at best. However, proptosis in all but two has been stabilized and has not deteriorated in the follow-up period. Most of the patients have experienced an improvement of eye-muscle motility. Extraocular muscles that work for elevation were impaired more severely than the other muscles and this tended to remain. Of the 16 patients using steroids before or when radiotherapy was initiated, 15 were tapered off and only one patient required additional steroids, thus sparing the majority from steroid adverse reactions. Radiotherapy was effective in preventing exacerbations of active inflammatory ophthalmopathy in patients with Graves` disease with minimal morbidity and thus eliminated the adverse reactions associated with protracted corticosteroid use. The newly developed motility limitation index was useful in detecting delicate changes in motility of individual extraocular muscles. (author)

  4. Les cellulites cervico-faciales graves, facteurs et critères de gravité

    Science.gov (United States)

    Lakouichmi, Mohammed; Tourabi, Khalid; Abir, Bader-eddine; Zouhair, Said; Lahmiti, Saad; Hattab, Nadia Mansouri

    2014-01-01

    La cellulite cervico-faciale grave est une infection polymicrobienne extensive et redoutable du tissu cellulo-adipeux de la face et du cou. L'objectif de cette étude est d'analyser certains facteurs favorisants et d’évaluer les critères de gravité en fonction des formes anatomo-cliniques. Il s'agit d'une étude rétrospective réalisée, entre janvier 2007 et décembre 2012, au service de chirurgie maxillo faciale de l'hôpital militaire Avicenne de Marrakech. Sur 147 cas de cellulites cervico-faciales pris en charge au niveau du service, 13 dossiers de cellulites graves ont été retenus. Neuf hommes (69%) et quatre femmes (31%) ont fait l'objet de cette étude, avec un âge moyen de 35 ans. Tous les patients ont été adressés pour prise en charge secondaire après avoir pris des anti-inflammatoires (AI). Sept cas (54%) étaient immunocompétents. La cause dentaire était soulevée chez neufs cas (69%). Cinq cas (38%) ont présenté une forme pseudo phlegmoneuse avec des signes compressifs des voies aéro-digestives. L'extension médiastinale a été observée chez quatre patients (31%). La forme nécrosante extensive a été retrouvée dans trois cas (23%). L’étude bactériologique, réalisée chez tous les patients, avait mis en évidence une flore microbienne mixte et polymorphe. Les cellulites cervico-faciales graves posent un réel problème de prise en charge thérapeutique. L'analyse des facteurs favorisants et l’évaluation des critères de gravité dans cette série ont permis de limiter une évolution défavorable. PMID:26113891

  5. "独草"大事故%A Grave Accident by A Single Grass

    Institute of Scientific and Technical Information of China (English)

    孙殿阁

    2002-01-01

    @@ 草遍地皆是,随处可见.一草一木不足为奇,何以谈得上大事故呢? 事情发生在二十世纪五十年代,吉林丰满水力发电厂.这里群山环绕,近百米高巍巍的混凝土大坝将松花江拦腰截断,在两山峡谷之间,座落着美丽的松花湖.某个夏季,在大坝的夹缝微土之间长出了一些杂草.年复一年,发电厂运行十多年了,谁也没有注意到这些无足轻重的杂草.

  6. Graves' Disease that Developed Shortly after Surgery for Thyroid Cancer

    Directory of Open Access Journals (Sweden)

    Hea Min Yu

    2013-09-01

    Full Text Available Graves' disease is an autoimmune disorder that may present with various clinical manifestations of hyperthyroidism. Patients with Graves' disease have a greater number of thyroid nodules and a higher incidence of thyroid cancer compared with patients with normal thyroid activity. However, cases in which patients are diagnosed with recurrence of Graves' disease shortly after partial thyroidectomy for thyroid cancer are very rare. Here we report a case of hyperthyroid Graves' disease that occurred after partial thyroidectomy for papillary thyroid cancer. In this case, the patient developed hyperthyroidism 9 months after right hemithyroidectomy, and antithyroglobulin autoantibody and thyroid stimulating hormone receptor stimulating autoantibody were positive. Therefore, we diagnosed Graves' disease on the basis of the laboratory test results and thyroid ultrasonography findings. The patient was treated with and maintained on antithyroid drugs. The mechanism of the recurrence of Graves' disease in this patient is still unclear. The mechanism may have been the improper response of the immune system after partial thyroidectomy. To precisely determine the mechanisms in Graves' disease after partial thyroidectomy, further studies based on a greater number of cases are needed.

  7. Psychiatric manifestations of Graves' hyperthyroidism: pathophysiology and treatment options.

    Science.gov (United States)

    Bunevicius, Robertas; Prange, Arthur J

    2006-01-01

    Graves' disease is an autoimmune disorder that is the most common cause of hyperthyroidism. Other symptoms associated with the disease are goitre, ophthalmopathy, and psychiatric manifestations such as mood and anxiety disorders and, sometimes, cognitive dysfunction. Graves' hyperthyroidism may result in these latter manifestations via the induction of hyperactivity of the adrenergic nervous system. This review addresses the psychiatric presentations, and their pathophysiology and treatment, in patients with hyperthyroidism, based on literature identified by a PubMed/MEDLINE database search. Although the focus is on mental symptoms associated with Graves' disease, it is not always clear from the literature whether patients had Graves' disease: in some studies, the patients were thought to have Graves' disease based on clinical findings such as diffuse goitre or ophthalmopathy or on measurements of thyroid antibodies in serum; however, in other studies, no distinction was made between Graves' hyperthyroidism and hyperthyroidism from other causes. Antithyroid drugs combined with beta-adrenoceptor antagonists are the treatments of choice for hyperthyroidism, as well as for the psychiatric disorders and mental symptoms caused by hyperthyroidism. A substantial proportion of patients have an altered mental state even after successful treatment of hyperthyroidism, suggesting that mechanisms other than hyperthyroidism, including the Graves' autoimmune process per se and ophthalmopathy, may also be involved. When psychiatric disorders remain after restoration of euthyroidism and after treatment with beta-adrenoceptor antagonists, specific treatment for the psychiatric symptoms, especially psychotropic drugs, may be needed.

  8. Traffic Accidents on Slippery Roads

    DEFF Research Database (Denmark)

    Fonnesbech, J. K.; Bolet, Lars

    2014-01-01

    Police registrations from 65 accidents on slippery roads in normally Danish winters have been studied. The study showed: • 1 accident per 100 km when using brine spread with nozzles • 2 accidents per 100 km when using pre wetted salt • 3 accidents per 100 km when using kombi spreaders The results...

  9. Boating Accident Statistics

    Data.gov (United States)

    Department of Homeland Security — Accident statistics available on the Coast Guard’s website by state, year, and one variable to obtain tables and/or graphs. Data from reports has been loaded for...

  10. Accident resistant transport container

    Science.gov (United States)

    Andersen, John A.; Cole, James K.

    1980-01-01

    The invention relates to a container for the safe air transport of plutonium having several intermediate wood layers and a load spreader intermediate an inner container and an outer shell for mitigation of shock during a hypothetical accident.

  11. The Fukushima accident; Accident nucleaire a Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Delbecq, D.

    2012-02-15

    The Fukushima accident is characterized by a sequence of natural disasters: earthquake and tsunamis that deprived simultaneously 3 reactors from cooling and electrical power for quite a long time. A series of hydrogen explosion has added to the mess. Experts agree to say that certainly nuclear fuel has melt to form corium in all 3 reactors. The accident has contaminated tens of thousand acres of land around the plant and has jeopardized local coastal fishery. The human toll is unexpectedly low: no direct casualty in the population but several suicides among the people that was forced to leave their home. 5 people from the plant staff died certainly from the consequences of the tsunami. (A.C.)

  12. Accidents with sulfuric acid

    OpenAIRE

    Rajković Miloš B.

    2006-01-01

    Sulfuric acid is an important industrial and strategic raw material, the production of which is developing on all continents, in many factories in the world and with an annual production of over 160 million tons. On the other hand, the production, transport and usage are very dangerous and demand measures of precaution because the consequences could be catastrophic, and not only at the local level where the accident would happen. Accidents that have been publicly recorded during the last eigh...

  13. Concomitant Graves' disease and Hashimoto's thyroiditis, presenting as primary hypothyroidism.

    LENUS (Irish Health Repository)

    Cronin, C C

    2012-02-03

    Hypothyroidism in patients with Graves\\' disease is usually the result of ablative treatment. We describe a 58 year old man with Graves\\' ophthalmopathy and pre-tibial myxoedema, who presented with spontaneous primary hypothyroidism. Circulating TSH receptor antibody activity was increased, while thyroid microsomal antibody was detectable in titres greater than one in one hundred thousand. It is likely that the TSH receptor antibody of Graves\\' disease was ineffective in stimulating hyperthyroidism because of concomitant thyroid destruction due to Hashimoto\\'s disease. Alternatively, primary hypothyroidism could have resulted from the effects of a circulating TSH receptor blocking antibody.

  14. Cyclical Fluctuations in Workplace Accidents

    OpenAIRE

    Boone, J.; J. C. VAN OURS

    2002-01-01

    This Paper presents a theory and an empirical investigation on cyclical fluctuations in workplace accidents. The theory is based on the idea that reporting an accident dents the reputation of a worker and raises the probability that he is fired. Therefore a country with a high or an increasing unemployment rate has a low (reported) workplace accident rate. The empirical investigation concerns workplace accidents in OECD countries. The analysis confirms that workplace accident rates are invers...

  15. Successful treatment of Graves disease in pregnancy with Lugol's iodine.

    Science.gov (United States)

    Jamieson, A; Semple, C G

    2000-02-01

    We report a case of Grave's disease in pregnancy complicated by intolerance of standard antithyroid drug therapy. We describe the success of prolonged use of organic iodine as a primary treatment prior to surgical intervention.

  16. Historic Sites and Grave Markers at Litttle Bighorn Battlefield, Montana

    Data.gov (United States)

    National Park Service, Department of the Interior — This is a vector point file showing the historic sites and grave markers at Little Bighorn Battlefield National Monument (LIBI). The coordinates for this dataset...

  17. Paracentral Corneal Dellen:A Rare Sign of Graves Ophthalmopathy

    Institute of Scientific and Technical Information of China (English)

    Jianhua Yan; Zhongyao Wu

    2003-01-01

    Purpose: To report a rare sign, paracentral corneal dellen that developed in a middleaged female patient with Graves ophthalmopathy.Methods:A paracentral corneal dellen developed in the left eye in a 42-year-old woman who was diagnosed as Graves ophthalmopathy. The patient had remarkable upper eyelid retraction, upper eyelid lag and upward motility restriction. The Graves ophthalmopathy was classified as Grade V according to NOSPECS classification.Results:Local artificial tear film and 0.3% Tobramycin eye drops were administered to both eyes.Twenty-four hours later, the left corneal dellen disappeared.Conclusions:Graves ophthalmopathy can lead to paracentral corneal dellen because of severe upper eyelid retraction and upward motility restriction of the eye in spite of the lack of lagophthalmos. Artificial tear drop and antibiotic eye drop therapy helped even though the patient did not have corneal exposure.

  18. Anaesthetic Challenges In An Untreated Grave's Disease Parturient ...

    African Journals Online (AJOL)

    Alasia Datonye

    hyperthyroidism in pregnancy is challenging to perioperative care ... associated with untreated Graves ' disease in pregnancy. Method: .... pregnancy, symptoms of fatigue, heat intolerance, and. 7 ... Magnesium produces a dose-dependent.

  19. CASE REPORT : GRAVE'S DISEASE PRESENTING AS PARANOID SCHIZOPHRENIA

    OpenAIRE

    Singh, S. K.; Hatwal, A.; Agarwal, J.K.; Bajpai, H.S.; Sharma, I

    1989-01-01

    SUMMARY The case of a 37 year old male is described who initially presented as paranoid schizophrenia unresponsive to anti-psychotic drug treatment and subsequently developed features of Grave's disease. Treatment with carbimazole alone improved his psychiatric symptoms.

  20. Orbital metastases from neuroendocrine carcinoma, masquerading as graves orbitopathy.

    Science.gov (United States)

    Sira, Mano; Clauss, Ralf P; Maclean, Chris; Rose, Geoffrey E

    2010-04-01

    We describe a patient with metastases from neuroendocrine carcinoma masquerading as Graves ophthalmopathy. This rare tumour possibly has a propensity for orbital spread, and we postulate a mechanism evoking the 'seed and soil' hypothesis.

  1. Accidents in nuclear ships

    Energy Technology Data Exchange (ETDEWEB)

    Oelgaard, P.L. [Risoe National Lab., Roskilde (Denmark)]|[Technical Univ. of Denmark, Lyngby (Denmark)

    1996-12-01

    This report starts with a discussion of the types of nuclear vessels accidents, in particular accidents which involve the nuclear propulsion systems. Next available information on 61 reported nuclear ship events in considered. Of these 6 deals with U.S. ships, 54 with USSR ships and 1 with a French ship. The ships are in almost all cases nuclear submarines. Only events that involve the sinking of vessels, the nuclear propulsion plants, radiation exposures, fires/explosions, sea-water leaks into the submarines and sinking of vessels are considered. For each event a summary of available information is presented, and comments are added. In some cases the available information is not credible, and these events are neglected. This reduces the number of events to 5 U.S. events, 35 USSR/Russian events and 1 French event. A comparison is made between the reported Soviet accidents and information available on dumped and damaged Soviet naval reactors. It seems possible to obtain good correlation between the two types of events. An analysis is made of the accident and estimates are made of the accident probabilities which are found to be of the order of 10{sup -3} per ship reactor years. It if finally pointed out that the consequences of nuclear ship accidents are fairly local and does in no way not approach the magnitude of the Chernobyl accident. It is emphasized that some of the information on which this report is based, may not be correct. Consequently some of the results of the assessments made may not be correct. (au).

  2. Orbital dissection defatting technique for Graves disease.

    Science.gov (United States)

    Hecht, S D; Guibor, P; Wolfley, D; Wiggs, E O

    1984-04-01

    Five patients with Graves disease and bilateral proptosis were treated with different incisional approaches. They all underwent orbital decompression by removal of the anterior medial orbital walls, the anterior ethmoidal sinuses, the orbital floors, and multiple incisions of the orbital periosteums . The defatting technique, which consists of applying manual anterior orbital pressure with alternate removing of small lobules of fat, was added when it was intraoperatively decided by Hertel exophthalmometer measurement that more decompression was needed. It is estimated that one-third more reduction in proptosis resulted. An average total decrease in proptosis of 9 mm per orbit occurred. Both visual accuities and visual fields returned to normal. The only important complication was the development of hypertropia in down gaze in one patient. A potential value of this technique is its use with orbital floor decompression alone. It may be possible to avoid removing the medial and lateral walls of the orbit, thereby decreasing complications. Defatting may also be a valuable addition in those rare cases where all decompression techniques available are needed to affect an adequate decompression.

  3. Miastenia grave distal: relato de caso

    Directory of Open Access Journals (Sweden)

    Scola Rosana Herminia

    2003-01-01

    Full Text Available Relatamos o caso de uma mulher de 30 anos com quadro de fraqueza muscular nos membros inferiores com predomínio distal com início há 7 anos. Na evolução apresentou fraqueza muscular nos membros superiores. O exame físico mostrava nervos cranianos sem alterações, hipotrofia bilateral de quadriceps e interósseos dos pés, redução da força muscular mais intensa em tibiais anteriores e interósseos dorsais dos pés e reflexos tendinosos globalmente hipoativos. Foi realizado teste de estimulação repetitiva que mostrou decremento maior que 10% no nervo fibular e ulnar. A dosagem de anticorpos anti-receptor de acetilcolina foi positiva. Tomografia computadorizada de tórax foi normal. Dosagem de hormônios tireoidianos mostrou evidências laboratoriais de hipertireoidismo, porém sem manifestações clínicas. Foi iniciado tratamento com piridostigmina havendo melhora importante do quadro clínico. A fraqueza distal é um sintoma inicial raro na miastenia grave (MG. Contudo, a MG deve entrar no diagnóstico diferencial de doenças que cursam com fraqueza muscular distal de membros superiores ou inferiores.

  4. ENFERMEDADES GRAVES CON DIAGNÓSTICO PRENATAL

    Directory of Open Access Journals (Sweden)

    Carmen María Samaniego Fernández

    2012-01-01

    Full Text Available El objetivo de este artículo es presentar la información publicada hasta el momento sobre la supervivencia, las secuelas y la calidad de vida de las enfermedades mencionadas por la declaración de la Comisión de Bioética de la Sociedad Española de Ginecología y Obstetricia (SEGO como extremadamente graves e incurables, subsidiarias de interrupción voluntaria del embarazo más allá de las veintidós semanas de edad gestacional, según lo contemplado por la Ley Orgánica 2/2010 de Salud Sexual y Reproductiva y de la Interrupción Voluntaria del Embarazo. Los profesionales sanitarios deben conocer los aspectos médicos, los avances terapéuticos y el pronóstico de dichas enfermedades, siendo un deber ético transmitir dicha información a los progenitores.

  5. Lymphocyte-platelet crosstalk in Graves' disease.

    Science.gov (United States)

    Kuznik, Boris I; Vitkovsky, Yuri A; Gvozdeva, Olga V; Solpov, Alexey V; Magen, Eli

    2014-03-01

    Platelets can modulate lymphocytes' role in the pathophysiology of thyroid autoimmune diseases. The present study was performed to clarify the status of platelet-lymphocyte subpopulations aggregation in circulating blood in patients with Graves' disease (GD). One hundred and fifty patients with GD (GD group) and 45 hyperthyroid patients with toxic multinodular goiter (TMG group) were recruited in the study. Control group consisted 150 healthy subjects. Immunophenotyping of lymphocytes was performed by flow cytometry. Detection of lymphocyte-platelet aggregates (LPAs) was done using light microscope after Ficoll-gradient centrifugation. The group of GD patients exhibited reduced CD8 lymphocyte and higher CD19 cell counts compared with TMG group and healthy controls. A greater number of activated CD3, HLA-DR+ lymphocytes were observed in GD than in TMG group and control group. GD group was characterized by lower blood platelet count (232 ± 89 × 10 cells/µL) than TMG group (251 ± 97 × 10 cells/µL; P < 0.05) and control group (262 ± 95 × 10 cells/µL; P < 0.05). In GD group, more platelet-bound lymphocytes (332 ± 91 /µL) were found than that in TMG group (116 ± 67/µL, P < 0.005) and control group (104 ± 58 /µL; P < 0.001). GD is associated with higher levels of activated lymphocytes and lymphocyte-platelet aggregates.

  6. Delineation of graves using electrical resistivity tomography

    Science.gov (United States)

    Nero, Callistus; Aning, Akwasi Acheampong; Danuor, Sylvester K.; Noye, Reginald M.

    2016-03-01

    A suspected old royal cemetery has been surveyed at the Kwame Nkrumah University of Science and Technology (KNUST) campus, Kumasi, Ghana using Electrical Resistivity Tomography (ERT) with the objective of detecting graves in order to make informed decisions with regard to the future use of the area. The survey was conducted on a 10,000 m2 area. Continuous Vertical Electrical Sounding (CVES) was combined with the roll along technique for 51 profiles with 1 m probe separation separated by 2 m. Inverted data results indicated wide resistivity variations ranging between 9.34 Ωm and 600 Ωm in the near surface. Such heterogeneity suggests a disturbance of the soil at this level. Both high (≥ 600 Ωm) and low resistivity (≤ 74.7 Ωm) anomalies, relative to background levels, were identified within the first 4 m of the subsurface. These were suspected to be burial tombs because of their rectangular geometries and resistivity contrasts. The results were validated with forward numerical modeling results. The study area is therefore an old cemetery and should be preserved as a cultural heritage site.

  7. Preclinical models of Graves' disease and associated secondary complications.

    Science.gov (United States)

    Moshkelgosha, Sajad; So, Po-Wah; Diaz-Cano, Salvador; Banga, J Paul

    2015-01-01

    Autoimmune thyroid disease is the most common organ-specific autoimmune disorder which consists of two opposing clinical syndromes, Hashimoto's thyroiditis and Graves' (hyperthyroidism) disease. Graves' disease is characterized by goiter, hyperthyroidism, and the orbital complication known as Graves' orbitopathy (GO), or thyroid eye disease. The hyperthyroidism in Graves' disease is caused by stimulation of function of thyrotropin hormone receptor (TSHR), resulting from the production of agonist antibodies to the receptor. A variety of induced mouse models of Graves' disease have been developed over the past two decades, with some reproducible models leading to high disease incidence of autoimmune hyperthyroidism. However, none of the models show any signs of the orbital manifestation of GO. We have recently developed an experimental mouse model of GO induced by immunization of the plasmid encoded ligand binding domain of human TSHR cDNA by close field electroporation that recapitulates the orbital pathology in GO. As in human GO patients, immune mice with hyperthyroid or hypothyroid disease induced by anti-TSHR antibodies exhibited orbital pathology and chemosis, characterized by inflammation of orbital muscles and extensive adipogenesis leading to expansion of the orbital retrobulbar space. Magnetic resonance imaging of the head region in immune mice showed a significant expansion of the orbital space, concurrent with proptosis. This review discusses the different strategies for developing mouse models in Graves' disease, with a particular focus on GO. Furthermore, it outlines how this new model will facilitate molecular investigations into pathophysiology of the orbital disease and evaluation of new therapeutic interventions.

  8. Human lymphocyte antigens (HLA) and Graves' disease in Turkey.

    Science.gov (United States)

    Orhan, Y; Azezli, A; Carin, M; Aral, F; Sencer, E; Molvalilar, S

    1993-09-01

    To evaluate the association of HLA types with Turkish patients with Graves' disease, HLA typing, clinical findings, and thyroid antibodies were correlated. The HLA types, clinical findings (ophthalmopathy and age at onset), and thyroid stimulating hormone (TSH) receptor (TRAb) and antithyroid microsomal antibodies (MAb) were analyzed. Seventy Turkish patients with Graves' disease and 306 control subjects were assessed. Serological HLA typing was performed in HLA A, B, C, DR, and DQ loci. There was a significantly increased prevalence of HLA B8, B49, DR3, DR4, and DR10 in Graves' disease. The association of Graves' disease with HLA DR3 was found to be less strong than previously described. The HLA DR4 antigen may contribute to the predisposition of Graves' disease in Turkey. The results suggest that HLA B7, B13, DR7, DQw2, and DQw3 may confer a protective effect for Graves' disease in Turkey. Patients carrying HLA B12, B18, and B44 haplotypes had a tendency to develop the disease at a later age. The difference from the other studies may be the result of the selection of the controls; in part, of the variability in serological typing reagents; and, also, of the rather weak HLA associations with the disease.

  9. Who by accident? The social morphology of car accidents.

    Science.gov (United States)

    Factor, Roni; Yair, Gad; Mahalel, David

    2010-09-01

    Prior studies in the sociology of accidents have shown that different social groups have different rates of accident involvement. This study extends those studies by implementing Bourdieu's relational perspective of social space to systematically explore the homology between drivers' social characteristics and their involvement in specific types of motor vehicle accident. Using a large database that merges official Israeli road-accident records with socioeconomic data from two censuses, this research maps the social order of road accidents through multiple correspondence analysis. Extending prior studies, the results show that different social groups indeed tend to be involved in motor vehicle accidents of different types and severity. For example, we find that drivers from low socioeconomic backgrounds are overinvolved in severe accidents with fatal outcomes. The new findings reported here shed light on the social regularity of road accidents and expose new facets in the social organization of death. © 2010 Society for Risk Analysis.

  10. Miastenia grave ocular Severe ocular myastenia

    Directory of Open Access Journals (Sweden)

    Yaimir Estevéz Miranda

    2010-01-01

    Full Text Available La miastenia grave es una enfermedad autoinmune de la unión neuromuscular que se caracteriza por la variabilidad de la debilidad muscular, que empeora o está provocada por el ejercicio del músculo o de los grupos musculares implicados, mientras que el descanso la mejora. La primera descripción de la enfermedad data de 1672, su relación con una afección del timo no se estableció hasta 1901. La enfermedad es poco frecuente, afecta a todas las etnias por igual, y no tiene predilección geográfica. Se reporta un paciente masculino de 28 años de edad atendido en el Servicio de Oftalmología Pediátrica del Instituto Cubano de Oftalmología "Ramón Pando Ferrer" por presentar visión doble, ptosis palpebral ligera en ojo derecho que empeora con el transcurso del día. Por el interrogatorio y el cuadro clínico se sospecha de una miastenia grave, se remite al clínico y el neurólogo. En los estudios realizados de neuroimágenes, tomografía y electroencefalograma no se encontraron alteraciones. Se decide valorar el caso con el servicio de Neuroftalmología de nuestro centro y por el Instituto de Neurología y es confirmado el diagnóstico.Myasthenia gravis is an autoimmune illness of the neuromuscular joint that is characterized by the variability of the muscular weakness that worsens or caused by exercising of the muscle or the involved muscular groups; resting helps in improving the condition of the muscle. The first description of the illness dates back to 1672, but its linking to a thymus disorder was not discovered until 1901. This illness is not very frequent, affects equally to all the races, and it does not predominate in any particular geographic region. This paper presented a male patient aged 28 years who went to the Ophthalmologic Service at "Ramón Pando Ferrer" Cuban Institute of Ophthalmology because he suffered from double vision, slight palpebral ptosis in his right eye that became worse as the day went by. After the

  11. ALICE Injected Beam Accidents

    CERN Document Server

    Appleby, R B

    2009-01-01

    The ALICE (point 2) interaction region is sensitive to beam orbit errors arising from magnet setting errors on injection. In this report, beam accident scenarios under injection for ALICE are described, focusing on ultra- fast error injection scenarios for the interaction straight correctors and dipoles. Beam 1 and beam 2 accident scenarios are considered, where the errors can lead to beam orbits striking the ALICE vacuum chamber or elements of the machine. The required thresholds for magnet current interlocks are calculated to avoid machine and detector risk.

  12. LHCb Injected Beam Accidents

    CERN Document Server

    Appleby, R B

    2009-01-01

    The LHCb (point 8) interaction region is sensitive to beam orbit errors arising from magnet setting errors on injection. In this report, beam accident scenarios under injection for LHCb are described, focusing on ultra- fast error injection scenarios for the interaction straight correctors and dipoles. Beam 1 and beam 2 accident scenarios are considered, where the errors can lead to beam orbits striking the LHCb vacuum chamber or elements of the machine. The required thresholds for magnet current interlocks are calculated to avoid machine and detector risk.

  13. Analisis Kebijakan dan Efektivitas Organisasi

    Directory of Open Access Journals (Sweden)

    Amir Syarifudin Kiwang

    2015-05-01

    Full Text Available Penerapan Peraturan Gubernur Nusa Tenggara Timur Nomor 8 Tahun 2011 tentang Organisasi dan Tata Kerja Unit Pelaksana Teknis Pendidikan dan Pelatihan Koperasi dan Usaha Mikro Kecil dan Menengah pada Dinas Koperasi dan Usaha Mikro Kecil dan Menengah Provinsi Nusa Tenggara Timur adalah dalam rangka untuk meningkatkan efektivitas kerja organisasi pada UPT Diklat Koperasi dan UMKM. Penelitian ini berusaha untuk melihat dampak kebijakan organisasi terhadap efektivitas organisasi dengan menggunakan enam elemen variabel dari kebijakan dan praktik manajemen. Keenam elemen tersebut adalah penetapan tujuan strategis, pencarian dan pemanfaatan sumber daya, lingkungan prestasi, proses komunikasi, kepemimpinan dan pengambilan keputusan, serta adaptasi dan inovasi organisasi. Penelitian kualitatif ini menggunakan pendekatan studi kasus. Teknik analisis data yang digunakan adalah analisis data model Miles dan Huberman, yang terdiri atas reduksi data, display/penyajian data, dan kesimpulan/verifikasi. Hasil penelitian menunjukkan bahwa efektivitas organisasi pada UPT Diklat koperasi dan UMKM belum berjalan secara baik, hal ini dapat dilihat dari beberapa hal antara lain, belum adanya tenaga spesialisasi pengelola diklat dan tenaga khusus (sarjana di bidang perkoperasian dan kondisi lingkungan kerja (lingkungan prestasi pada UPT Diklat koperasi dan UMKM yang belum efektif. Penempatan pegawai juga belum tepat, mutasi ke UPT Diklat Koperasi dan UMKM tidak memperhatikan latar belakang pendidikan dan spesialisasi/keahlian pegawai sehingga membutuhkan waktu dalam proses penyesuaian serta menurunkan jumlah pelaksanaan diklat dikarenakan keterbatasan alokasi dana.

  14. Guide Suva de l'assurance contre les accidents

    CERN Document Server

    2004-01-01

    Le présent Guide de la Suva permet au lecteur de se retrouver dans les dispositions légales sur l’assurance-accidents. Il est divisé en trois parties: La première partie commente en neuf chapitres la loi sur l’assurance-accidents et la loi fédérale sur la partie générale du droit des assurances sociales, ainsi que leurs ordonnances. Chaque chapitre est précédé des questions les plus fréquemment posées à propos des sujets qui y sont traités. Les réponses succinctes à ces questions facilitent l’approche des différents sujets et donnent un aperçu du contenu du chapitre. Dans la partie explicative, les dispositions concernées font l’objet d’une référence dans la marge. La deuxième partie contient toutes les lois et ordonnances importantes pour l’acti vité quotidienne de la Suva (parfois seulement sous forme d’extraits). Des couleurs différentes permettent de mieux les distinguer. La troisième partie regroupe les moyens d’information et les adresses de la Suva les plus imp...

  15. Lessons learned from accidents investigations

    Energy Technology Data Exchange (ETDEWEB)

    Zuniga-Bello, P. [Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico City (Mexico); Croft, J. [National Radiological Protection Board (United Kingdom); Glenn, J

    1997-12-31

    Accidents from three main practices: medical applications, industrial radiography and industrial irradiators are used to illustrate some common causes of accidents and the main lessons to be learned. A brief description of some of these accidents is given. Lessons learned from the described accidents are approached by subjects covering: safety culture, quality assurance, human factors, good engineering practice, defence in depth, security of sources, safety assessment and monitoring and verification compliance. (author)

  16. Keratoacanthoma Dan Perawatannya

    OpenAIRE

    Indah Heriyanti

    2008-01-01

    Keratoacanthoma adalah suatu tumor jinak yang berasal dari jaringan epitel dan biasanya di jumpai pada permukaan kulit yang umumnya terjadi pada bagian kulit yang sering terkena sinar matahari dimana tumor ini dapat sembuh dengan spontan. Lesi ini biasanya berawal sebagai makula yang kecil yang berwarna merah dan kemudian menjadi papula yang kokoh dan bersisik pada permukaanya. Papul ini dengan cepat membesar selama 2 sampai 8 minggu. Pada awalnya berbentuk bulat atau oval,kokoh menonjol ...

  17. DEPRESI DAN GANGGUAN TIDUR

    Directory of Open Access Journals (Sweden)

    Wayan Eko Radityo

    2012-12-01

    Full Text Available Depresi merupakan gangguan mood berupa kesedihan yang intens, berlangsung dalamwaktu lama, dan mengganggu kehidupan normal yang insidennya semakin meningkatseiring dengan meningkatnya tekanan hidup. Tahun 2020, depresi diperkirakanmenempati urutan kedua penyakit di dunia. Gejala-gejala depresi terdiri dari gangguanemosi, gangguan kognitif, keluhan somatik, gangguan psikomotor, dan gangguanvegetatif. Salah satu gejala depresi yang muncul adalah gangguan tidur yang bisaberupa insomnia, bangun secara tiba-tiba, dan hipersomnia. Hal ini disebabkan olehgangguan neurotransmiter dan regulasi hormon. Selain sebagai gejala depresi, gangguantidur juga bisa merupakan penyebab depresi. Beberapa penelitian memberikanhubungan gangguan tidur dapat meningkatkan risiko depresi di kemudian hari.

  18. Authority structure and industrial accidents

    NARCIS (Netherlands)

    As, Sicco van

    2001-01-01

    This paper deals with the influence of organizational characteristics on safety. Accidents are actually caused by individual mistakes. However the underlying causes of accidents are often organizational. The general hypothesis is that the authority structure is a main cause of accident-proneness

  19. Color-flow Doppler sonography in Graves disease: "thyroid inferno".

    Science.gov (United States)

    Ralls, P W; Mayekawa, D S; Lee, K P; Colletti, P M; Radin, D R; Boswell, W D; Halls, J M

    1988-04-01

    Graves disease is a common diffuse abnormality of the thyroid gland usually characterized by thyrotoxicosis. We performed color-flow Doppler sonography in 16 patients with Graves disease and compared the results with those in 15 normal volunteers and 14 patients with other thyroid diseases (eight with multinodular goiter, four with focal masses, and two with papillary thyroid carcinoma). All 16 Graves disease patients exhibited a pulsatile pattern we call "thyroid inferno." This pattern consists of multiple small areas of intrathyroidal flow seen diffusely throughout the gland in both systole and diastole. In systole, both high-velocity flow (color coded white) and lower velocity flow (color coded red and blue) were noted. In diastole, fewer areas of flow and lower velocity flow were noted. Patients with Graves disease also exhibited color flow around the periphery of the gland. The inferno pattern did not occur in normal subjects or in patients with other thyroid diseases. On occasion, focal areas of intrathyroidal flow were detected in patients with multinodular goiter and focal thyroid masses. High-resolution gray-scale images did not show the small vascular channels from which the flow signal originated. Color-flow Doppler sonography shows promise as a cost-effective, noninvasive technique for diagnosing Graves disease.

  20. Chernobyl accident and its consequences

    Energy Technology Data Exchange (ETDEWEB)

    Gittus, J.H.

    1987-06-01

    The paper concerns the Chernobyl reactor accident, with emphasis on the design of the RBMK reactor and nuclear safety. A description is given of the Chernobyl nuclear power plant, including details of the RMBK reactor and safety systems. Comments on the design of the RBMK by UK experts prior to the accident are summarized, along with post-accident design changes to improve RBMK safety. Events of the Chernobyl accident are described, as well as design deficiencies highlighted by the accident. Differences between the USSR and UK approaches to nuclear safety are commented on. Finally source terms, release periods and environmental consequences are briefly discussed.

  1. An update on the medical treatment of Graves' hyperthyroidism.

    Science.gov (United States)

    Marinò, Michele; Latrofa, Francesco; Menconi, Francesca; Chiovato, Luca; Vitti, Paolo

    2014-11-01

    Medical treatment of Graves' hyperthyroidism is based on the use of thionamides; namely, methimazole and propylthiouracil. In the past, methimazole was preferred by European endocrinologists, whereas propylthiouracil was the first choice for the majority of their North American colleagues. However, because of the recent definition of a better side-effect profile, methimazole is nowadays the first choice world while. Although thionamides are quite effective for the short-term control of Graves' hyperthyroidism, a relatively high proportion of patients relapses after thionamide withdrawal. Other possible medical treatments, include iodine and compounds containing iodine, perchlorate, lithium (as an adjuvant in patients undergoing radioiodine therapy), β-adrenergic antagonists, glucocorticoids, and some new molecules still under investigation. Management of Graves' hyperthyroidism using thionamides as well as the other available medical treatments is here reviewed in detail, with a special mention of situations such as pregnancy and lactation, as well as neonatal and fetal thyrotoxicosis.

  2. Esclerodermia, tireoidite e miastenia grave: estudo de um caso

    Directory of Open Access Journals (Sweden)

    Antonio L. dos Santos Werneck

    1993-11-01

    Full Text Available Uma paciente de 36 anos com miastenia grave desenvolveu após dois anos intolerância ao frio, o que conduziu ao diagnóstico de tireoidite de Hashimoto. Quatro anos mais tarde apresentou pele espessada nas mãos (esclerodermia limitada. O quadro clínico e os exames complementares encaminharam o diagnóstico para a forma CREST de esclerodermia sistêmica progressiva. Discute-se a dificuldade diagnóstica da esclerodermia, assim como suas síndromes de superposição. Doença de Hashimoto e miastenia grave constituem associação pouco frequente. A presença de esclerodermia e miastenia grave é rara. Não encontramos na literatura a coincidência destas três doenças.

  3. Clinical experience of radiation therapy for Graves` ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Takeo; Mitsuhashi, Norio; Nagashima, Hisako; Sakurai, Hideyuki; Murata, Osamu; Ishizeki, Kei; Shimaya, Sanae; Hayakawa, Kazushige; Niibe, Hideo [Gunma Univ., Maebashi (Japan). School of Medicine

    1996-11-01

    The effect of radiation therapy for Graves` ophthalmopathy was evaluated. Ten patients with Graves` ophthalmopathy were treated with radiation therapy between 1992 and 1993 in Gunma University Hospital. All patients had a past history of hyperthyroidism and received 2,000 cGy to the retrobulbar tissues in 20 fractions. Nine of ten patients were treated with radiation therapy after the failure of corticosteroids. Six patients (60%) showed good or excellent responses. The exophthalmos type was more responsive to radiation therapy than the double vision type in this series. Two of five patients with the exophthalmos type demonstrated excellent responses, and their symptoms disappeared almost completely. The improvement of symptoms appeared within 3-6 months, and obvious clinical effects were demonstrated after 6 months of radiotherapy. Radiation therapy was well tolerated, and we have not observed any side effects of radiation therapy. In conclusion, radiation therapy is effective treatment for Graves` ophthalmopathy. (author)

  4. Occupational accidents aboard merchant ships

    DEFF Research Database (Denmark)

    Hansen, H.L.; Nielsen, D.; Frydenberg, Morten

    2002-01-01

    Objectives: To investigate the frequency, circumstances, and causes of occupational accidents aboard merchant ships in international trade, and to identify risk factors for the occurrence of occupational accidents as well as dangerous working situations where possible preventive measures may...... be initiated. Methods: The study is a historical follow up on occupational accidents among crew aboard Danish merchant ships in the period 1993–7. Data were extracted from the Danish Maritime Authority and insurance data. Exact data on time at risk were available. Results: A total of 1993 accidents were...... rate of accidents than Danish citizens. Age was a major risk factor for accidents causing permanent disability. Change of ship and the first period aboard a particular ship were identified as risk factors. Walking from one place to another aboard the ship caused serious accidents. The most serious...

  5. Thyroid Ultrasonography in Differentiation between Graves' Disease and Hashimoto's Thyroiditis.

    Science.gov (United States)

    Pishdad, P; Pishdad, G R; Tavanaa, S; Pishdad, R; Jalli, R

    2017-03-01

    Graves' disease and Hashimoto's thyroiditis are the most common causes of hyper and hypothyroidism, respectively. Differentiation of these 2 diseases, if the patient is euthyroid, may sometimes be extremely difficult on the basis of clinical and laboratory findings. The purpose of this study was to determine the sensitivity and specificity of gray scale sonography in differentiation of Graves' disease from Hashimoto's thyroiditis. This study included 149 patients divided into three groups, patients with Graves' disease (34 patients, mean age = 36.8 ± 10.17 years), Patients with Hashimoto's thyroiditis (62 patients, mean age = 33.4 ± 12.16 years) and control group (53 healthy people, mean age = 34.74 ± 16.87 years). Members of all groups were referred to a single radiologist for thyroid sonography for evaluation of thyroid echogenicity pattern. A total of 117 women and 32 men were examined by sonography. The most common sonographic pattern in Hashimoto and Graves' was homogenous hypo-echogenicity which was observed in 45.2% and 47.1% of cases, respectively. Peripheral hypo-echogenicity pattern was seen in 40.3% of Hashimoto's group with 100% specificity and 40.3% sensitivity. Central-hypoechogenic pattern was observed in 17.6% of Graves' group with 100% and 17.6% specificity and sensitivity, respectively. Our findings indicate that sonography has high specificity but low sensitivity in the diagnosis of either Graves' disease or Hashimoto's thyroiditis. It is therefore not possible to differentiate between these two diseases using sonography alone. Confirmation by laboratory data is also needed.

  6. Comparative evaluation of oculometric variables in graves' ophthalmopathy

    Directory of Open Access Journals (Sweden)

    Hélio Amante Miot

    2009-01-01

    Full Text Available OBJECTIVES: To estimate oculometric parameters of Graves' ophthalmopathy in comparison to healthy eyes using digital photography and digital image analysis. INTRODUCTION: Graves' ophthalmopathy is the main cause of eye proptosis. Because these protrusions cause clinically perceived distortions in orbital architecture, digital photographs can be used to detect and quantify these changes. METHODS: We carried out a cross-sectional study comprising 12 healthy volunteers and 15 Graves' ophthalmopathy patients with the purpose of evaluating the use of simple, non-invasive digital photography to estimate oculometric parameters of Graves' ophthalmopathy and compare them with the parameters of unaffected eyes. Facial photographs of cases and controls were taken in a standardized manner. Oculometric parameters were compared between the groups and then correlated to proptometer measures. RESULTS: All estimated oculometric variables showed significant differences between the groups, in particular with regard to mediopupilar aperture, lateral height, distance from the iris edge to the lateral boundary of the palpebral fissure, and distance from the higher point of the iris to the lateral limit of the palpebral fissure. The product of medial aperture and horizontal palpebral fissure also revealed greater discrepancy between the groups. Proptometer measures showed significant linear correlation between the distance from the iris edge to the lateral boundary of the palpebral fissure and between the distance from the higher point of the iris to the lateral limit of palpebral fissure (p<0.05. CONCLUSIONS: Comparative analysis of oculometric parameters in Graves' ophthalmopathy suggests that eye proptosis is related to an asymmetric increase in lateral oculometric measures. Standardized digital photographs can be used in clinical practice to objectively estimate oculometric parameters of Graves' ophthalmopathy patients.

  7. Intérêt du registre du Rhône pour le suivi des victimes. Vers une meilleure définition du blessé grave, des incidences aux prévalences

    OpenAIRE

    Chiron, M

    2001-01-01

    Comme tous les registres, le registre du Rhône des victimes d'accidents de la circulation permet de mesurer des incidences. Par exemple : sept personnes sur mille sont blessées chaque année dans un accident de la circulation (dont plus d'une sur cent meurt). Une connaissance précise de l'incidence de telle ou telle lésion traumatique par accident de la circulation est possible, ainsi que celle de la mortalité immédiate. Ainsi une personne sur mille est victime chaque année du 'coup du lapin' ...

  8. Hipertrigliceridemia familiar grave durante a gestação

    OpenAIRE

    Luiz Augusto Casulari; Myrian Wesgueber; Ricardo Cassiano B. Silva; Soares,Henrique F.; Lucilia Domingues

    2001-01-01

    A presença de hipertrigliceridemia grave durante a gravidez é rara, mas comporta grande possibilidade de desenvolver complicações, como a pancreatite aguda, que coloca em risco a mãe e o feto. Apresentamos o relato da evolução da gestação de uma paciente portadora de hipertrigliceridemia grave que havia apresentado pancreatite aguda dois meses antes da fecundação. Foi tratada durante o pré-natal com dieta e 3,0 g de ácidos graxos de cadeia ômega-3 (ácidos eicosapentaenóico 14% e docosahexaenó...

  9. Peripartum cardiomyopathy in a patient with Graves' disease.

    Science.gov (United States)

    Kajiya, Takashi; Lee, Souki; Yamashita, Makoto; Sasaki, Yuichi; Kamizono, Yusuke; Imamura, Masakazu; Toyonaga, Koichi; Toda, Hitoshi; Koriyama, Nobuyuki; Tei, Chuwa

    2010-11-05

    Peripartum cardiomyopathy (PPCM) is a rare life-threatening cardiomyopathy of unknown etiology that occurs during the peripartum period in previously healthy women. Autoimmune and viral factors have been suggested to be involved in PPCM. Here we describe a patient with Graves' disease, which is one of the organ-specific autoimmune diseases, who developed acute heart failure due to PPCM at 2 weeks after her first delivery. The patient recovered completely with conservative treatment for heart failure. An association between PPCM and Graves' disease has not been reported before. PPCM may be an organ-specific autoimmune disease, so the coexistence of other autoimmune diseases should be considered in PPCM patients.

  10. Dissociative disorder due to Graves' hyperthyroidism: a case report.

    Science.gov (United States)

    Mizutani, Kaoru; Nishimura, Katsuji; Ichihara, Atsuhiro; Ishigooka, Jun

    2014-01-01

    We report the case of a 20-year-old Japanese woman with no psychiatric history with apparent dissociative symptoms. These consisted of amnesia for episodes of shoplifting behaviors and a suicide attempt, developing together with an exacerbation of Graves' hyperthyroidism. Patients with Graves' disease frequently manifest various psychiatric disorders; however, very few reports have described dissociative disorder due to this disease. Along with other possible causes, for example, encephalopathy associated with autoimmune thyroid disease, clinicians should be aware of this possibility. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Thymic Hyperplasia Presenting as a Neck Mass in Graves Disease

    Directory of Open Access Journals (Sweden)

    Serkan Yener

    2009-06-01

    Full Text Available We describe a female patient who presented with Graves disease and a neck mass. Radiological characteristics of the mass suggested thymic hyperplasia. She was treated with methimazole, and because the mass did not regress after six months of therapy, the patient had total thyroidectomy and thymectomy. Pathological examination was consistent with chronic lymphocytic thyroiditis and thymic hyperplasia. Microscopic changes in the thymus can be detected in one third of patients with Graves disease, but massive enlargement is rare. It has been reported that regression occurs in most patients after a euthyroid state has been achieved; however, in some patients, thymectomy may be indicated. Turk Jem 2009; 13: 11-2

  12. Hipertrigliceridemia familiar grave durante a gestação

    OpenAIRE

    Casulari Luiz Augusto; Wesgueber Myrian; Silva Ricardo Cassiano B.; Soares Henrique F.; Domingues Lucilia

    2001-01-01

    A presença de hipertrigliceridemia grave durante a gravidez é rara, mas comporta grande possibilidade de desenvolver complicações, como a pancreatite aguda, que coloca em risco a mãe e o feto. Apresentamos o relato da evolução da gestação de uma paciente portadora de hipertrigliceridemia grave que havia apresentado pancreatite aguda dois meses antes da fecundação. Foi tratada durante o pré-natal com dieta e 3,0 g de ácidos graxos de cadeia ômega-3 (ácidos eicosapentaenóico 14% e docosahexaenó...

  13. Treating the thyroid in the presence of Graves' ophthalmopathy

    DEFF Research Database (Denmark)

    Hegedüs, Laszlo; Bonnema, Steen J; Smith, Terry J

    2012-01-01

    The etiology of Graves' orbitopathy (GO) remains enigmatic. Optimal therapeutic choices for the hyperthyroidism associated with Graves' disease (GD) in the presence of GO remain controversial. Whether antithyroid drugs (ATDs), radioiodine (RAI), or thyroidectomy should be favored in such patients...... - independent of extent - do not influence the natural course of GO. RAI can cause de novo development or progression of GO, which is largely preventable with oral steroid prophylaxis. In patients with mild GO, the thyroid treatment is largely independent of GO. Moderate to severe GO should be treated promptly...

  14. Graves' disease presenting as pseudotumor cerebri: a case report

    Directory of Open Access Journals (Sweden)

    Freitas Cláudia

    2011-02-01

    Full Text Available Abstract Introduction Pseudotumor cerebri is an entity characterized by elevated intracranial pressure with normal cerebrospinal fluid and no structural abnormalities detected on brain MRI scans. Common secondary causes include endocrine pathologies. Hyperthyroidism is very rarely associated and only three case reports have been published so far. Case presentation We report the case of a 31-year-old Luso-African woman with clinical symptoms and laboratory confirmation of Graves' disease that presented as pseudotumor cerebri. Conclusion This is a rare form of presentation of Graves' disease and a rare cause of pseudotumor cerebri. It should be remembered that hyperthyroidism is a potential cause of pseudotumor cerebri.

  15. [Drowning accidents in childhood].

    Science.gov (United States)

    Krandick, G; Mantel, K

    1990-09-30

    This is a report on five boys aged between 1 and 5 years who, after prolonged submersion in cold water, were treated at our department. On being taken out of the water, all the patients were clinically dead. After 1- to 3-hour successful cardiopulmonary resuscitation, with a rectal temperature of about 27 degrees C, they were rewarmed at a rate of 1 degree/hour. Two patients died within a few hours after the accident. One patient survived with an apallic syndrome, 2 children survived with no sequelae. In the event of a water-related accident associated with hypothermia, we consider suitable resuscitation to have preference over rewarming measures. The most important treatment guidelines and prognostic factors are discussed.

  16. RENEB accident simulation exercise

    OpenAIRE

    Brzozowska, Beata; Ainsbury, Elizabeth; Baert, Annelot; Beaton-Green, Lindsay; Barrios, Leonardo; Barquinero, Joan Francesc; Bassinet, Celine; Beinke, Christina; Benedek, Anett; Beukes, Philip; Bortolin, Emanuela; Buraczewska, Iwona; Burbidge, Christopher; De Amicis, Andrea; De Angelis, Cinzia

    2017-01-01

    Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing potentially large data sets that would be generated in case of a major radiological event. Materials and methods: Each participant was offered the possibility to activate the network by sending an alerting email about a simulated radiation emergency. The same participant had to collect, compile and report capacity, triage categorization and exposure scenario results ob...

  17. Messiniense: compleja y grave crisis ecologica

    Directory of Open Access Journals (Sweden)

    Aguirre, E.

    2003-08-01

    yacimientos de mamíferos fósiles en España y otras regiones con importantes novedades, entre ellas diversos intercambios intercontinentales, en el mismo intervalo cronológico añaden cuestiones de interés además de obligar a la correlación entre la estratigrafía basada en series marinas y la biostratigrafía continental. A las singularidades de estas series se añade el descubrimiento reciente de homínidos fósiles con indicios de bipedia en edades comprendidas en este intervalo. En el mismo se han datado graves eventos paleogeográficos, geodinámicos, paleoambientales y paleoclimáticos, que empezaron a investigarse hace 40 años como la «Crisis de Salinidad del Mediterráneo*, y sobre cuyo desarrollo e interacciones se han publicado diversos modelos más o menos incompletos: aislamiento del mediterráneo, descenso global del nivel del mar, acreción continental y orogenia, glaciación, deterioro de la cubierta vegetal. Una interpretación de la secuencia de eventos en estos diversos campos de estudio de Historia de la Tierra y de la Vida, y sus interacciones, puede trazarse con una calibración del orden de los cien mil años.

  18. Localization of a sound source in in a guided medium and reverberating field. Contribution to a study on leak localization in the internal wall of containment of a nuclear reactor in the case of a severe reactor accident; Localisation d`une source acoustique en milieu guide et champ reverberant. Contribution a l`etude sur la localisation de fuite de l`enceinte de confinement d`une centrale nucleaire en situation accidentelle grave

    Energy Technology Data Exchange (ETDEWEB)

    Thomann, F

    1996-11-28

    Basic data necessary for the localization of a leak in the internal wall of the containment are presented by studying the sound generated by gas jets coming out of (leaking fissures) as well as propagation in a guided medium. The results acquired have led us to choose the simple intercorrelation method and the matched filed processing method, both of which are likely to adequately handle our problems. Whereas the intercorrelation method appears to be limited in scope when dealing in the guided medium, the matched field processing is suited to leak localization over a surface of approximately 1000 m{sup 2} (for a total surface of 10 000 m{sup 2}). Preliminary studies on the leak signal and on replicated signals have led us to limit the frequency band to 2600 - 3000 Hz. We have succeeded in locating a leak situated in an ordinary position with a minimum amount of replicated signals and basic data. We have improved on the estimation of Bartlett and MVDE (minimum variance distortion less filter) rendering them even more effective. Afterwards, we considered the severe accident situation and showed that the system can be installed in situ. (author) 88 refs.

  19. PREVENTION OF OCCUPATIONAL ACCIDENTS

    Directory of Open Access Journals (Sweden)

    Jovica Jovanovic

    2004-01-01

    Full Text Available Medical services, physicians and nurses play an essential role in the plant safety program through primary treatment of injured workers and by helping to identify workplace hazards. The physician and nurse should participate in the worksite investigations to identify specific hazard or stresses potentially causing the occupational accidents and injuries and in planning the subsequent hazard control program. Physicians and nurses must work closely and cooperatively with supervisors to ensure the prompt reporting and treatment of all work related health and safety problems. Occupational accidents, work related injuries and fatalities result from multiple causes, affect different segments of the working population, and occur in a myriad of occupations and industrial settings. Multiple factors and risks contribute to traumatic injuries, such as hazardous exposures, workplace and process design, work organization and environment, economics, and other social factors. With such a diversity of theories, it will not be difficult to understand that there does not exist one single theory that is considered right or correct and is universally accepted. These theories are nonetheless necessary, but not sufficient, for developing a frame of reference for understanding accident occurrences. Prevention strategies are also varied, and multiple strategies may be applicable to many settings, including engineering controls, protective equipment and technologies, management commitment to and investment in safety, regulatory controls, and education and training. Research needs are thus broad, and the development and application of interventions involve many disciplines and organizations.

  20. Auto-estima na forma inativa da oftalmopatia de Graves Inactive Graves' ophthalmopathy and self-esteem

    Directory of Open Access Journals (Sweden)

    Carlos Henrique de Toledo Magalhães

    2008-04-01

    Full Text Available OBJETIVOS: Avaliar a auto-estima dos pacientes com oftalmopatia de Graves na fase inativa. MÉTODOS: Foram avaliados 30 pacientes portadores de oftalmopatia de Graves, eutireoideanos, na fase inativa, com idade variando entre 26 e 65 anos, média 43 ± 11,0 anos, denominado grupo estudo e 39 indivíduos que não apresentavam oftalmopatia de Graves, com idade variando entre 18 e 67 anos, média de 41 ± 13,4 anos, selecionados na população geral denominado grupo controle. Para avaliar a auto-estima foi utilizada a escala de auto-estima Rosenberg Unifesp-EPM aplicada por meio de entrevista. Os valores dos escores de auto-estima nos dois grupos estudados foram comparados pelo teste não paramétrico de Mann-Whitney. O mesmo teste foi aplicado com objetivo de comparar os resultados obtidos no grupo oftalmopatia de Graves considerando a gravidade da doença. RESULTADOS: Não foi observada alteração com significância estatística na auto-estima dos pacientes com oftalmopatia de Graves (p=0,057. O grupo estudo apresentou, em média, valores inferiores de auto-estima, comparado ao grupo controle. Não houve diferença da auto-estima entre os pacientes dos subgrupos leve e moderado-grave (P=0,2710. CONCLUSÃO: A oftalmopatia de Graves na fase inativa não afetou a auto-estima dos pacientes, no grupo estudado.PURPOSE: To assess the self-esteem of Graves' ophthalmopathy patients in the inactive phase. METHODS: Thirty euthyroid patients were evaluated in the inactive phase of disease with age ranging from 26 to 65 years, average of 43 ± 11,0 years, called study group and 39 individuals without Graves' ophthalmopathy with age ranging from 18 to 67 years, average of 41 ± 13,4 years, selected from the general population called control group. To evaluate the self-esteem the Rosenberg UNIFESP/EPM self-esteem scale, applied by means of an interview, was utilized. The self-esteem scores in the two studied groups were compared by means of the non

  1. 78 FR 22292 - Native American Graves Protection and Repatriation Review Committee: Notice of Nomination...

    Science.gov (United States)

    2013-04-15

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Notice of.... SUMMARY: The National Park Service is soliciting nominations for one member of the Native American Graves... nominations submitted by Indian tribes, Native Hawaiian organizations, and traditional Native...

  2. 77 FR 65406 - Native American Graves Protection and Repatriation Review Committee: Notice of Nomination...

    Science.gov (United States)

    2012-10-26

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Notice of.... SUMMARY: The National Park Service is soliciting nominations for one member of the Native American Graves... nominations submitted by Indian tribes, Native Hawaiian organizations, and traditional Native...

  3. [Chernobyl nuclear power plant accident and Tokaimura criticality accident].

    Science.gov (United States)

    Takada, Jun

    2012-03-01

    It is clear from inspection of historical incidents that the scale of disasters in a nuclear power plant accident is quite low level overwhelmingly compared with a nuclear explosion in nuclear war. Two cities of Hiroshima and Nagasaki were destroyed by nuclear blast with about 20 kt TNT equivalent and then approximately 100,000 people have died respectively. On the other hand, the number of acute death is 30 in the Chernobyl nuclear reactor accident. In this chapter, we review health hazards and doses in two historical nuclear incidents of Chernobyl and Tokaimura criticality accident and then understand the feature of the radiation accident in peaceful utilization of nuclear power.

  4. Evidence for a major role of heredity in Graves' disease

    DEFF Research Database (Denmark)

    Brix, T H; Kyvik, K O; Christensen, Kaare

    2001-01-01

    The etiology of Graves' disease (GD), affecting up to 2% of a population in iodine-sufficient areas, is incompletely understood. According to current thinking, the development of GD depends on complex interactions among genetic, environmental, and endogenous factors. However, the relative...

  5. A patient with Graves' disease, thrombocytopenia and chronic hepatitis B.

    OpenAIRE

    Szeto, C C; Chow, C C; Ko, G. T.; K. Y. LI; Yeung, V. T.; Cockram, C S

    1997-01-01

    A 22-year-old Chinese man, a HBsAg carrier, presented with relapse of thyrotoxic Graves' disease complicated by thrombocytopenia and hepatitis. Platelet count and liver enzymes gradually improved following successful treatment of the thyrotoxicosis with radioactive iodine. Possible pathogenetic links and therapeutic implications are discussed.

  6. [Central congenital hypothyroidism due to Graves' disease in the mother

    NARCIS (Netherlands)

    Liebrand, C.A.; Mol, A.C. de; Kempers, M.J.E.; Noordam, C.

    2006-01-01

    Two male twins were born at a gestational age of 30 weeks. Five days after delivery, the mother was diagnosed with Graves' disease. The thyroid function in the neonates was therefore evaluated, which led to the detection of central congenital hypothyroidism (central CHT), even though the neonatal

  7. Measuring disease activity to predict therapeutic outcome in Graves' ophthalmopathy

    NARCIS (Netherlands)

    Terwee, C.B.; Prummel, M.F.; Gerding, M.N.; Kahaly, G.J.; Dekker, F.W.; Wiersinga, W.M.

    2005-01-01

    OBJECTIVE: The concept of disease activity in Graves' ophthalmopathy (GO) might explain why as many as one-third of patients do not respond to immunosuppressive treatment, because only patients in the active stage of disease are expected to respond. The hypothesis was adopted that a parameter used

  8. Radiotherapy for Graves' orbitopathy : randomised placebo-controlled study

    NARCIS (Netherlands)

    Mourits, MP; van Kempen-Harteveld, ML; Garcia, MBG; Koppeschaar, HPF; Tick, L; Terwee, CB

    2000-01-01

    Background The best treatment (steroids, irradiation, or both) for moderately severe Graves' orbitopathy, a self-limiting disease is not known. We tested the efficacy of external beam irradiation compared with sham-irradiation. Methods In a double-blind randomised clinical trial, 30 patients with

  9. Treatment of Graves' hyperthyroidism: evidence-based and emerging modalities

    DEFF Research Database (Denmark)

    Hegedüs, Laszlo

    2009-01-01

    Currently there are three well-established treatment options for hyperthyroid Graves' disease (GD): antithyroid drug therapy with thionamides (ATD), radioactive iodine treatment with (131)I, and thyroid surgery. This article reviews the current evidence so the reader can evaluate advantages...

  10. Selenium and the Course of Mild Graves' Orbitopathy

    NARCIS (Netherlands)

    C. Marcocci; G.J. Kahaly; G.E. Krassas; L. Bartalena; M. Prummel; M. Stahl; M.A. Altea; M. Nardi; S. Pitz; K. Boboridis; P. Sivelli; G. von Arx; M.P. Mourits; L. Baldeschi; W. Bencivelli; W. Wiersinga

    2011-01-01

    Background Oxygen free radicals and cytokines play a pathogenic role in Graves' orbitopathy. Methods We carried out a randomized, double-blind, placebo-controlled trial to determine the effect of selenium (an antioxidant agent) or pentoxifylline (an antiinflammatory agent) in 159 patients with mild

  11. Radiotherapy for Graves' orbitopathy : randomised placebo-controlled study

    NARCIS (Netherlands)

    Mourits, MP; van Kempen-Harteveld, ML; Garcia, MBG; Koppeschaar, HPF; Tick, L; Terwee, CB

    2000-01-01

    Background The best treatment (steroids, irradiation, or both) for moderately severe Graves' orbitopathy, a self-limiting disease is not known. We tested the efficacy of external beam irradiation compared with sham-irradiation. Methods In a double-blind randomised clinical trial, 30 patients with mo

  12. Measuring disease activity to predict therapeutic outcome in Graves' ophthalmopathy

    NARCIS (Netherlands)

    Terwee, C.B.; Prummel, M.F.; Gerding, M.N.; Kahaly, G.J.; Dekker, F.W.; Wiersinga, W.M.

    2005-01-01

    OBJECTIVE: The concept of disease activity in Graves' ophthalmopathy (GO) might explain why as many as one-third of patients do not respond to immunosuppressive treatment, because only patients in the active stage of disease are expected to respond. The hypothesis was adopted that a parameter used t

  13. Graves' disease: thyroid function and immunologic activity

    Energy Technology Data Exchange (ETDEWEB)

    Gossage, A.A.R.; Crawley, J.C.W.; Copping, S.; Hinge, D.; Himsworth, R.L.

    1982-11-01

    Patients with Graves' disease were studied for two years during and after a twelve-month course of treatment. Disease activity was determined by repeated measurements of thyroidal uptake of (/sup 9/-9..mu..Tc)pertechnetate during tri-iodothyronine administration. These in-vivo measurements of thyroid stimulation were compared with the results of in-vitro assays of Graves, immunoglobulin (TSH binding inhibitory activity - TBIA). There was no correlation between the thyroid uptake and TBIA on diagnosis. Pertechnetate uptake and TBIA both declined during the twelve months of antithyroid therapy. TBIA was detectable in sera from 19 of the 27 patients at diagnosis; in 11 of these 19 patients there was a good correlation (p<0.05) throughout the course of their disease between the laboratory assay of the Graves, immunoglobulin and the thyroid uptake. Probability of recurrence can be assessed but sustained remission of Graves' disease after treatment cannot be predicted from either measurement alone or in combination.

  14. Graves' disease: thyroid function and immunologic activity

    Energy Technology Data Exchange (ETDEWEB)

    Gossage, A.A.; Crawley, J.C.; Copping, S.; Hinge, D.; Himsworth, R.L.

    1982-11-01

    Patients with Graves' disease were studied for two years during and after a twelve-month course of treatment. Disease activity was determined by repeated measurements of thyroidal uptake of (/sup 99m/Tc)pertechnetate during tri-iodothyronine administration. These in-vivo measurements of thyroid stimulation were compared with the results of in-vitro assays of Graves, immunoglobulin (TSH binding inhibitory activity--TBIA). There was no correlation between the thyroid uptake and TBIA on diagnosis. Pertechnetate uptake and TBIA both declined during the twelve months of antithyroid therapy. TBIA was detectable in sera from 19 of the 27 patients at diagnosis; in 11 of these 19 patients there was a good correlation (p less than 0.05) throughout the course of their disease between the laboratory assay of the Graves, immunoglobulin and the thyroid uptake. Probability of recurrence can be assessed but sustained remission of Graves' disease after treatment cannot be predicted from either measurement alone or in combination.

  15. 78 FR 21410 - Native American Graves Protection and Repatriation Review Committee: Meetings

    Science.gov (United States)

    2013-04-10

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meetings AGENCY... Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of two meetings of the Native American Graves... Advisory Committee Act, 5 U.S.C. Appendix (1988), of two meetings of the Native American Graves...

  16. 77 FR 23196 - Native American Graves Protection and Repatriation Act Regulations

    Science.gov (United States)

    2012-04-18

    ... Office of the Secretary 43 CFR Part 10 RIN 1024-AD99 Native American Graves Protection and Repatriation... Secretary of the Interior (Secretary) is responsible for implementation of the Native American Graves... implementing the Native American ] Graves Protection and Repatriation Act for purposes of factual accuracy...

  17. 77 FR 65407 - Native American Graves Protection and Repatriation Review Committee: Notice of Nomination...

    Science.gov (United States)

    2012-10-26

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Notice of.... SUMMARY: The National Park Service is soliciting nominations for one member of the Native American Graves... Review Committee was established by the Native American Graves Protection and Repatriation Act of...

  18. 77 FR 39406 - Safety Zone; Tom Graves Memorial Fireworks, Port Bay, Wolcott, NY

    Science.gov (United States)

    2012-07-03

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Tom Graves Memorial Fireworks, Port Bay... from a portion of Port Bay during the Tom Graves Memorial Fireworks display. This temporary safety zone... vessels during the Tom Graves Memorial Fireworks. This zone will be effective and enforced from 9:30 p.m...

  19. The work of the South Manchester Accident Rescue Team (SMART).

    Science.gov (United States)

    Redmond, A D

    1990-01-01

    Skills acquired in the hospital do not necessarily translate to the scene of an accident. However, training in certain hospital specialties, particularly accident and emergency medicine, will expose doctors to dealing with very ill patients in a less rigidly structured environment. The operating theatre is a disciplined and controlled environment. Skill in anaesthesia, monitoring and operating, if tested only in these circumstances may be found to be gravely inadequate when exposed to the fluctuant and hostile environment at the site. Doctors who wish to do this sort of work or are designated to do it, must undergo regular and frequent training, especially if they are not trained in accident and emergency departments. This has long been recognised by the British Association for Immediate Care. In combination with the Royal College of Surgeons of Edinburgh they have now established a diploma in Immediate Medical Care. In urban areas the need for a doctor to attend at the scene of an accident is usually limited to entrapment. These occasions are likely to be infrequent and this can result in a lack of preparedness for such events. Interhospital transfer, primarily from peripheral hospitals to the specialist services of a teaching hospital, often involves critically ill and injured patients. The management of these cases by the mobile team provides regular, frequent exposure to working in a 'hostile' environment. Relationships with the rescue services are developed and staff become familiar with equipment and call-out procedures. The care of transported patients is improved. None of our patients have died in transit or within 6 h of arrival at base.(ABSTRACT TRUNCATED AT 250 WORDS)

  20. Personalised immunomodulating treatments for Graves' disease: fact or fiction?

    Science.gov (United States)

    Struja, Tristan Mirko; Kutz, Alexander; Fischli, Stefan; Meier, Christian; Müller, Beat; Schütz, Philipp

    2017-08-14

    Although Graves' disease has been recognised for more than 100 years, its physiopathological mechanisms are incompletely understood. Treatment strategies today mainly focus on suppression of thyroid hormone production by use of antithyroid drugs or radio-iodine, but neglect the underlying immunological mechanisms. Although Graves' disease is often seen as a prototype for an autoimmune mechanism, it is more likely to be a heterogeneous syndrome showing characteristics of both autoimmunity and immunodeficiency. The interplay of these two mechanisms may well characterise the physiopathology of this disease and its complications. Immunodeficiency may be either genetically determined or secondarily acquired. Various triggering events lead to autoimmunity with stimulation of the thyroid gland resulting in the clinical syndrome of hyperthyroidism. Also, relapse risk differs from patient to patient and can be estimated from clinical parameters incorporated into the Graves' Recurrent Events After Therapy (GREAT) score. Accurate risk stratification may help to distinguish high-risk patients for whom a more definitive treatment approach should be used from others where there is a high probability that the disease will recover with medical treatment alone. Several smaller trials having found positive effects of immunosuppressive drugs on recurrence risk in Graves' disease; therefoore, there is great potential in the use of novel immunomodulating drugs in addition to the currently used antithyroid drugs for the successful treatment of this condition. Further in-depth exploration of susceptibility, triggering factors and immunological mechanisms has the potential to improve treatment of Graves' disease, with more personalised, risk-adapted treatment strategies based on the different physiopathological concepts of this heterogeneous condition.

  1. Dan Performer Mei Lanfang

    DEFF Research Database (Denmark)

    Risum, Janne

    2010-01-01

    The convention of performing female characters (dan characters) in Beijing opera, as practised by its most prominent male performer of female characters Mei Lanfang, and its and his cultural context and aesthetic aim...

  2. Liever kraanwater dan bronwater

    NARCIS (Netherlands)

    Kole, A.P.W.

    2011-01-01

    Een test in het Restaurant van de Toekomst van de invloed van CO2-labels op het aankoopgedrag van consumenten, heeft nog geen duidelijk beeld opgeleverd. Wel pakten mensen vaker kraanwater dan bronwater.

  3. Radiation accident grips Goiania

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, L.

    1987-11-20

    On 13 September two young scavengers in Goiania, Brazil, removed a stainless steel cylinder from a cancer therapy machine in an abandoned clinic, touching off a radiation accident second only to Chernobyl in its severity. On 18 September they sold the cylinder, the size of a 1-gallon paint can, to a scrap dealer for $25. At the junk yard an employee dismantled the cylinder and pried open the platinum capsule inside to reveal a glowing blue salt-like substance - 1400 curies of cesium-137. Fascinated by the luminescent powder, several people took it home with them. Some children reportedly rubbed in on their bodies like carnival glitter - an eerie image of how wrong things can go when vigilance over radioactive materials lapses. In all, 244 people in Goiania, a city of 1 million in central Brazil, were contaminated. The eventual toll, in terms of cancer or genetic defects, cannot yet be estimated. Parts of the city are cordoned off as radiation teams continue washing down buildings and scooping up radioactive soil. The government is also grappling with the political fallout from the accident.

  4. Future Prospects for the Treatment of Graves' Hyperthyroidism and Eye Disease.

    Science.gov (United States)

    Neumann, S; Place, R F; Krieger, C C; Gershengorn, M C

    2015-09-01

    Although there are adequate therapies for Graves' hyperthyroidism, mild to moderate Graves' orbitopathy (GO) is usually treated symptomatically whereas definitive therapy is reserved for severe, vision-threatening GO. Importantly, none of the treatment regimens for Graves' disease used today are directed at the pathogenesis of the disease. Herein, we review some aspects of what is known about the pathogenesis of these 2 major components of Graves' disease, specifically the apparent important roles of the TSH and IGF-1 receptors, and thereafter describe future therapeutic approaches directed at these receptors. We propose that targeting these receptors will yield effective and better tolerated treatments for Graves' disease, especially for GO.

  5. Makna Dan Ideologi Punk

    OpenAIRE

    Daniar Wikan Setyanto

    2015-01-01

    Punk Sebagai sebuah subkultur telah diadaptasi oleh para remaja Indonesia bukan hanya sebagai semangat bermusik, namun merambah sebagai ideologi dan gaya hidup. Punk merupakan warisan budaya dari barat yang awalnya bergerak pada bidang musik, namun lambat lain punk telah menjadi sebuah identitas global yang mewakili para remaja radikal yang memiliki visi anti kemapanan dan anti pemerintah. Selain ideologinya yang kontroversi, punk mempengaruhi dinamika fashion di dunia. Asesoris punk diadapta...

  6. Assessment at the 66. day of projected external doses for populations living in the North-West fallout zone of the Fukushima nuclear accident. Impact of population evacuation measures; Evaluation au 66. jour des doses externes projetees pour les populations vivant dans la zone de retombee Nord-Ouest de l'accident nucleaire de Fukushima. Impact des mesures d'evacuation des populations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This document reports a dose assessment study performed by the IRSN (the French Radioprotection and Safety Nuclear Institute) 66 days after the Fukushima nuclear accident. A new dose assessment was carried out by IRSN to estimate projected doses due to external exposure from radioactive deposits, for exposure durations of 3 months, 1 year and 4 years before evacuation. The purpose of this report is to provide insight on all radiological assessments performed to the knowledge of the IRSN (the French Radioprotection and Safety Nuclear Institute) to date and the impact of population evacuation measures to be taken to minimize the medium and long-term risks of developing leukaemia or other radiation-induced cancers. This report only considers the external doses already received as well as the doses that may be received in the future from fallout deposits, regardless of doses received previously from the radioactive plume

  7. Fatal motorcycle accidents and alcohol

    DEFF Research Database (Denmark)

    Larsen, C F; Hardt-Madsen, M

    1987-01-01

    A series of fatal motorcycle accidents from a 7-year period (1977-1983) has been analyzed. Of the fatalities 30 were operators of the motorcycle, 11 pillion passengers and 8 counterparts. Of 41 operators 37% were sober at the time of accident, 66% had measurable blood alcohol concentration (BAC...

  8. Learning from incidents and accidents

    NARCIS (Netherlands)

    Drupsteen, L.; Kampen, J. van

    2014-01-01

    There are many different definitions for what constitutes an incident or an accident, however the focus is always on unintended and often unforeseen events that cause unintended consequences. This article is focused on the process of learning from incidents and accidents. The focus is on making sure

  9. [Practical management of CPB accident].

    Science.gov (United States)

    Depoix, J-P; Fenet, L; Provenchere, S

    2012-05-01

    Accident of CPB is a reality. It is important to be prepared for discussion with the family, with the hospital administration, eventually with the justice. But we have also to support perfusionnist and anesthetic team in charge of the patient during accident.

  10. Learning from incidents and accidents

    NARCIS (Netherlands)

    Drupsteen, L.; Kampen, J. van

    2014-01-01

    There are many different definitions for what constitutes an incident or an accident, however the focus is always on unintended and often unforeseen events that cause unintended consequences. This article is focused on the process of learning from incidents and accidents. The focus is on making sure

  11. World health day - 7th april, 2004 "road safety is no accident"

    Directory of Open Access Journals (Sweden)

    S C Saxena

    2006-06-01

    Full Text Available In 1948, the First World Health Assembly called for the creation of a "World Health Day". Since 1950, World Health Day has been celebrated on the 7th of April of each year. The objective of World Health Day is to raise global awareness of a specific health theme to highlight a priority area of concern for the World Health Organization (WHO. The Day serves as a launch for a long-term advocacy program for which activities will be undertaken and resources provided well beyond 7th April.To Celebrate the theme of this year "Road Safety is No accident", on 7th April 2004 around the globle, hundreds of organizations hosted events to help raise awareness about road traffic injuries, their grave consequences and enormous casts to society. They alsocontributed to spreading the message that such injuries can be prevented.In 1948, the First World Health Assembly called for the creation of a "World Health Day". Since 1950, World Health Day has been celebrated on the 7th of April of each year. The objective of World Health Day is to raise global awareness of a specific health theme to highlight a priority area of concern for the World Health Organization (WHO. The Day serves as a launch for a long-term advocacy program for which activities will be undertaken and resources provided well beyond 7th April.To Celebrate the theme of this year "Road Safety is No accident", on 7th April 2004 around the globle, hundreds of organizations hosted events to help raise awareness about road traffic injuries, their grave consequences and enormous casts to society. They alsocontributed to spreading the message that such injuries can be prevented.t '            ■The accident is defined as unexpected, unplanned event envolving injury, disability or death. The accidents occur in almost all countries. The most alarming fact is that accidents kill more young trained adults between 15-24 years of age group of males, mainly among two wheelers. All sorts of accidents

  12. 伊朗 Graves 眼病的临床特点%Clinical features of Graves' ophthalmopathy in Iran

    Institute of Scientific and Technical Information of China (English)

    Ali Sadeghi Tari; Mohammad Taher Rajabi; Khalil Hamzedust; Seyed Ziaeddin Tabatabaie; Abolfazl Kasai

    2007-01-01

    AIM:To determine the clinical characteristics of a prospective study of patients with Graves' ophthalmopathy.METHODS:We reviewed clinical manifestations,and medical records of 103 patients in whom Graves' ophthalmopathy WaS diagnosed between 2003 and 2005.RESULTS:Among 103 patients with Graves' ophthalmopathy,48(46.6%)male and 55(53.3%)female(F:M=1.1),with mean age of 45 (range;18-73) years,95 (92.2%)patients had Graves' hyperthyroidism,3(2.9%) had primary hypothyroidism,and 5 (4.8%) were euthyroid.The mean duration of ocular symptoms was 13.2 (range 2-95) months) while the mean duration of dysthyroid symptoms was 39.4(range 6-180) months.Unilaterality was occurred in 12 patients.Eyelid retraction was present in 90 patients (87%),whereas the approximate frequency of exophthalmos was 77.6%(80 patients);restrictive extraocular myopathy.29% (30 patients);evidence of extraocular enlargement on CT-scan in 52 patients of 70 patients (74%) that was evaluated,and optic nerve dysfunction,5.8%(6 patients).22(21%)patients hadglaucoma associated with Graves' ophthalmopathy that 7 (6.7%)of them were normal-tension glaucoma.CONCLUSION:Eyelid retraction Was the most common clinical sign of Graves' ophthalmopathy in our patients.Larger prospective studies are suggested to evaluate both the prevalenoe and possible racial difference in its dinical presentation in Iranian population.%目的:研究分析伊朗 Graves 眼病患者的临床特点.方法:回顾分析 2003/2005 年确诊为 Graves 眼病的103例患者临床资料.结果:在103例 Graves 眼病患者中,48例(46.6%)为男性,55例(53.3%)为女性(男女比例为1.1).年龄18-73(平均45)岁,95例(92.2%)表现为甲状腺机能亢进,3例(2.9%)表现为原发性甲状腺机能减退,5例(4.8%)甲状腺机能正常.出现眼部症状的时间为2~95 (平均3.2)mo,而表现出甲状腺功能障碍的时间为6~180(平均39.4)mo.12例患者单眼发病,90例(87%)患者有眼睑退缩,80例(77.6%)患者

  13. Traffic Accidents on Slippery Roads

    DEFF Research Database (Denmark)

    Fonnesbech, J. K.; Bolet, Lars

    2014-01-01

    Police registrations from 65 accidents on slippery roads in normally Danish winters have been studied. The study showed: • 1 accident per 100 km when using brine spread with nozzles • 2 accidents per 100 km when using pre wetted salt • 3 accidents per 100 km when using kombi spreaders The results...... of accidents in normally Danish winter seasons are remarkable alike the amount of salt used in praxis in the winter 2011/2012. • 2.7 ton NaCl/km when using brine spread with nozzles • 5 ton NaCl/km when using pre wetted salt. • 5.7 ton NaCl/km when using kombi spreaders The explanation is that spreading...

  14. Corporate Cost of Occupational Accidents

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.; Impgaard, M.

    2004-01-01

    method could be used in all of the companies without revisions. The evaluation of accident cost showed that 2/3 of the costs of occupational accidents are visible in the Danish corporate accounting systems reviewed while 1/3 is hidden from management view. The highest cost of occupational accidents......The systematic accident cost analysis (SACA) project was carried out during 2001 by The Aarhus School of Business and PricewaterhouseCoopers Denmark with financial support from The Danish National Working Environment Authority. Its focused on developing and testing a method for evaluating...... occupational costs of companies for use by occupational health and safety professionals. The method was tested in nine Danish companies within three different industry sectors and the costs of 27 selected occupational accidents in these companies were calculated. One of the main conclusions is that the SACA...

  15. Industrial accidents triggered by lightning.

    Science.gov (United States)

    Renni, Elisabetta; Krausmann, Elisabeth; Cozzani, Valerio

    2010-12-15

    Natural disasters can cause major accidents in chemical facilities where they can lead to the release of hazardous materials which in turn can result in fires, explosions or toxic dispersion. Lightning strikes are the most frequent cause of major accidents triggered by natural events. In order to contribute towards the development of a quantitative approach for assessing lightning risk at industrial facilities, lightning-triggered accident case histories were retrieved from the major industrial accident databases and analysed to extract information on types of vulnerable equipment, failure dynamics and damage states, as well as on the final consequences of the event. The most vulnerable category of equipment is storage tanks. Lightning damage is incurred by immediate ignition, electrical and electronic systems failure or structural damage with subsequent release. Toxic releases and tank fires tend to be the most common scenarios associated with lightning strikes. Oil, diesel and gasoline are the substances most frequently released during lightning-triggered Natech accidents.

  16. CRM+ severe Fletcher factor deficiency associated with Graves' disease.

    Science.gov (United States)

    Kyrle, P A; Niessner, H; Deutsch, E; Lechner, K; Korninger, C; Mannhalter, C

    1984-01-01

    A 59-year-old male patient with Graves' disease and severe hereditary Fletcher factor deficiency is described. PKK clotting activity as well as the activity by a chromogenic substrate method (Chromozym PK) was less then 0.01 U/ml. In contrast to functional tests, the immunological assay (Laurell method) showed a PKK antigen concentration of 0.25 U/ml, indicating the presence of an abnormal nonfunctional PKK molecule (CRM+ variant). An inhibitor was excluded since the patient plasma did not inactivate partially purified PKK. Investigation of 11 family members revealed a reduction of the PKK clotting activity in 9 relatives of the patient. Since Graves' disease is considered an autoimmune disease, our case represents an example of an association of a severe hereditary deficiency of a contact factor and an autoimmune disease.

  17. Doenças da tireoide e miastenia grave

    Directory of Open Access Journals (Sweden)

    J. Lamartine de Assis

    1984-09-01

    Full Text Available Os autores estudam o comportamento da tireóide em um grupo de 304 pacientes com miastenia grave, constatando 15 casos de tireopatias, sendo 9 de hipertireoidismo, um de hipotireoidismo e 5 de bócio sem alterações da função tireoidiana. Nenhum paciente era proveniente de região de bócio endêmico e não havia bócio familiar. A tireotoxicose, que foi a disfunção mais frequente, foi estudada quanto a sua prevalência em pacientes miastênicos, quanto a sua influência sobre os sintomas da miastenia grave e quanto à época do seu aparecimento.

  18. Habitat Evaluation Procedures Report; Graves Property - Yakama Nation.

    Energy Technology Data Exchange (ETDEWEB)

    Ashley, Paul; Muse, Anthony

    2008-02-01

    A habitat evaluation procedures (HEP) analysis was conducted on the Graves property (140 acres) in June 2007 to determine the number of habitat units to credit Bonneville Power Administration (BPA) for providing funds to acquire the property as partial mitigation for habitat losses associated with construction of McNary Dam. HEP surveys also documented the general ecological condition of the property. The Graves property was significantly damaged from past/present livestock grazing practices. Baseline HEP surveys generated 284.28 habitat units (HUs) or 2.03 HUs per acre. Of these, 275.50 HUs were associated with the shrubsteppe/grassland cover type while 8.78 HUs were tied to the riparian shrub cover type.

  19. Hipertrigliceridemia familiar grave durante a gestação

    Directory of Open Access Journals (Sweden)

    Casulari Luiz Augusto

    2001-01-01

    Full Text Available A presença de hipertrigliceridemia grave durante a gravidez é rara, mas comporta grande possibilidade de desenvolver complicações, como a pancreatite aguda, que coloca em risco a mãe e o feto. Apresentamos o relato da evolução da gestação de uma paciente portadora de hipertrigliceridemia grave que havia apresentado pancreatite aguda dois meses antes da fecundação. Foi tratada durante o pré-natal com dieta e 3,0 g de ácidos graxos de cadeia ômega-3 (ácidos eicosapentaenóico 14% e docosahexaenóico 11,13%. Os níveis de triglicerídeos foram mantidos abaixo de 800 mg/dl, sendo este limite considerado seguro para evitar o desenvolvimento de pancreatite aguda. A gestação evoluiu, sem intercorrências, para parto vaginal, a termo. O recém-nato não apresentou alterações morfológicas ao nascimento. Concluímos que, nesta paciente grávida e portadora de hipertrigliceridemia grave, uma dieta adequada e o emprego de ácidos graxos de cadeia ômega-3 foram eficazes em prevenir a pancreatite aguda. Esta abordagem terapêutica pode ser uma alternativa para as gestantes portadoras de hipertrigliceridemia familiar.

  20. New target for immunotherapy of Graves ophthalmopathy%Graves 眼病免疫治疗的新靶点

    Institute of Scientific and Technical Information of China (English)

    王坚

    2010-01-01

    @@ Graves 眼病(Graves ophthalmopathy,GO) 或称甲状腺相关性眼病(thyroid associated ophthalmopathy,TAO)是长期以来困扰内分泌医师的常见病症之一,目前尚无理想的治疗方法,常用免疫调节、球后放射照射、眼眶减压术等疗法.GO 的发病机制尚未完全明了,目前认为细胞免疫和体液免疫共同参与了GO 的发生和发展.

  1. INOVASI DAN STRATEGI PENCAPAIANNYA

    Directory of Open Access Journals (Sweden)

    Liem Ferryanto

    2009-01-01

    Full Text Available Innovation is the way of life of any institution to profitably sustain its life. It starts with empathy, the ability to reach outside of ourselves and walk in someone else’s shoes, and optimal implementation of the newly advanced technology. Innovation shows its results through continuously hard working efforts known as "10 Thousand Hours Rule". As world uncertainty creates complexity we, instead of predicting, should therefore anticipate the future by creating and managing real options on contingent projects or elements of alternative optimal strategies. This should reflect into our portfolio strategy. Abstract in Bahasa Indonesia: Inovasi merupakan darah bagi suatu institusi untuk bisa hidup berkelanjutan serta menguntungkan. Inovasi berupa penemuan baru secara sistematis yang berawal dari empati, kemampuan untuk melihat dunia melalui mata orang lain, dan pemanfaatan secara optimal kemajuan teknologi yang ada. Inovasi baru menghasilkan buahnya melalui kerja keras, yaitu dengan mengikuti “Aturan 10 Ribu Jam” secara berkesinambungan. Ketidakpastian, interaksi, keterbatasan dan degradasi menciptakan kompleksitas tentang kebutuhan dan solusi di masa depan. Oleh sebab itu daripada meramalkan risiko yang bakal terjadi, kita sebaiknya memasang strategi berupa skenario untuk mereduksi akibat dari risiko masa depan yang tidak kita mengerti. Skenario ini dapat diperoleh lewat penciptaan dan penanganan beberapa pilihan nyata atas semua proyek antisipatif yang ada. Kata kunci: Inovasi, ketidakpastian dan kompleksitas, aturan 10 ribu jam, paradoks strategi, peta jalan, empati, kerja berkesinambungan.

  2. Insuficiencia mitral grave posvalvuloplastia mitral percutánea

    Directory of Open Access Journals (Sweden)

    Julio C. Echarte Martínez

    2010-01-01

    Full Text Available RESUMENIntroducciónLa valvuloplastia mitral percutánea es en la actualidad el tratamiento de elección en pacientesportadores de estenosis mitral de etiología reumática si la anatomía es apropiada.La insuficiencia mitral grave posvalvuloplastia continúa siendo un desafío.ObjetivoDeterminar las causas de insuficiencia mitral grave posvalvuloplastia mitral.Material y métodosSe realizaron 110 valvuloplastias mitrales percutáneas en forma consecutiva en 107 pacientes(3 repetidas por reestenosis en el Instituto de Cardiología y Cirugía Cardiovascular deCuba, entre el 17 de junio de 1998 y el 30 de junio de 2004 (106 por el método de Inoue y 4por Multitrack; el tiempo de evolución promedio fue de 24,6 meses (máximo 72 y mínimo1,93 meses. La insuficiencia mitral se clasificó por ecocardiografía Doppler en leve si elárea regurgitante era menor de 4 cm2, moderada si era de 4-8 cm2. y grave si era > 8 cm2 ypor ventriculografía izquierda según los criterios de Sellers. Para lograr correlación entre laclasificación por ecocardiografía Doppler color de tres grados y la de Sellers (cuatro gradosla insuficiencia mitral 1+ se consideró leve, 2+ y 3+ moderada y 4+, grave.ResultadosSe produjeron cinco insuficiencias mitrales graves posprocedimiento (4,54% del total. Tresde ellas necesitaron reemplazo valvular mitral por rotura de la valva anterior. Las dos restantesse encuentran bajo tratamiento médico.ConclusiónLos mecanismos de producción de la insuficiencia mitral posvalvuloplastia mitral percutáneason multifactoriales. Puede ocurrir en manos expertas.REV ARGENT CARDIOL 2010;78:222-227.

  3. Les kystes hydatiques du foie rompus dans les voies biliaires: à propos de 120 cas

    Science.gov (United States)

    Moujahid, Mountassir; Tajdine, Mohamed Tarik

    2011-01-01

    Etude rétrospective rapportant une série de kystes hydatiques rompus dans les voies biliaires colligés dans le service de chirurgie de l'hôpital militaire Avicenne à Marrakech. Entre 1990 à 2008, sur 536 kystes hydatiques du foie opérés dans le service, 120 étaient compliqués de rupture dans les voies biliaires soit 22,38%. Il y avait 82hommes et 38 femmes. L’âge moyen était de 35 ans avec des extrêmes allant de 10 à 60 ans. La clinique était dominée par la crise d'angiocholite ou une douleur du flanc droit. L'ictère était isolé dans huit cas. La fistule biliokystique était latente dans plus de 50% des cas. Le traitement a consisté en une résection du dôme saillant dans103cas (85,84%), une périkystectomie chez 11 malades (9,16%) et une lobectomie gauche dans six cas (5%). Le traitement de la fistule bilio kystique a consisté en une suture chez 36malades et un drainage bipolaire dans 25 cas, La déconnexion kysto-biliaire ou cholédocotomie trans hépatico kystique selon Perdomo était pratiquée dans 49cas et une anastomose bilio-digestive cholédoco-duodénale dans 10 cas. La durée moyenne d'hospitalisation était de 20jours. Nous déplorons deux décès par choc septique et un troisième par encéphalopathie secondaire à une cirrhose biliaire. La morbidité était représentée par huit abcès sous phrénique, douze fistules biliaires prolongées et deux occlusions intestinales. Les kystes hydatiques rompus dans les voies biliaires représentent la complication la plus grave de cette pathologie bénigne. Le traitement repose sur des méthodes radicales qui sont d'une efficacité reconnue, mais de réalisation dangereuse et les méthodes conservatrices, en particulier la déconnexion kysto-biliaire qui est une méthode simple et qui donne de bons résultats à court et à long terme. PMID:22384289

  4. PENGELOLAAN PENELITIAN DAN PENGEMBANGAN KESEHATAN DI THAILAND, MYANMAR, DAN INDIA

    Directory of Open Access Journals (Sweden)

    Anorital, SKM Anorital, SKM

    2012-09-01

    Full Text Available Dalam bulan Januari 1991 yang lalu, Sdr. Anorital, SKM (Ka. Subbag. Pengumpulan dan PengolahanData Badan Litbangkes dan H. Syafwani Mirin, SKM (Ka. Bag. Keuangan Badan Litbangkes memperoleh fellowship dari WHO untuk melakukan studi perbandingan ke institusi-institusi penelitian kesehatan di Thailand,Myanmar, dan India.Berikut di bawah ini tulisan bersangkutan yang menggambarkan secara garis besar pengelolaan penelitian dan pengembangan kesehatan pada masing-masing negara obyek studi. Semoga informasi yang terkandung pada tulisan ini dapat bermanfaat bagi pengembangan Badan Penelitian dan Pengembangan Kesehatan.

  5. Chernobyl accident and its consequences

    Energy Technology Data Exchange (ETDEWEB)

    Gittus, J.H.; Bonell, P.G.; Hicks, D.

    1987-01-01

    The USSR power reactor programme is first described. The reasons for the accident at the Chernobyl-4 RBMK nuclear reactor on 26 April 1986, the sequence of events that took place, and the immediate and long-term consequences are considered. A description of the RBMK-type reactors is given and the design changes resulting from the experience of the accident are explained. The source terms describing the details of the radioactivity release associated with the accident and the environmental consequences are covered in the last two sections of the report. Throughout the text comments referring to the UK Nuclear Installations Inspectorate Safety assessment principles have been inserted. (U.K.).

  6. [Prevention of bicycle accidents].

    Science.gov (United States)

    Zwipp, H; Barthel, P; Bönninger, J; Bürkle, H; Hagemeister, C; Hannawald, L; Huhn, R; Kühn, M; Liers, H; Maier, R; Otte, D; Prokop, G; Seeck, A; Sturm, J; Unger, T

    2015-04-01

    For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher

  7. DanRIS

    DEFF Research Database (Denmark)

    2009-01-01

    Windows 2000/XP/Vista platform computerprogram til DanRIS indberetning baseret på indskrivning af klienter på CPR, klientsforløb, faseforløb, ASI EuropASI composite score beregninger. Udgave: 2.1.0.5 Udgivelsesdato: 01-01-2009......Windows 2000/XP/Vista platform computerprogram til DanRIS indberetning baseret på indskrivning af klienter på CPR, klientsforløb, faseforløb, ASI EuropASI composite score beregninger. Udgave: 2.1.0.5 Udgivelsesdato: 01-01-2009...

  8. Makna Dan Ideologi Punk

    Directory of Open Access Journals (Sweden)

    Daniar Wikan Setyanto

    2015-08-01

    Full Text Available Punk Sebagai sebuah subkultur telah diadaptasi oleh para remaja Indonesia bukan hanya sebagai semangat bermusik, namun merambah sebagai ideologi dan gaya hidup. Punk merupakan warisan budaya dari barat yang awalnya bergerak pada bidang musik, namun lambat lain punk telah menjadi sebuah identitas global yang mewakili para remaja radikal yang memiliki visi anti kemapanan dan anti pemerintah. Selain ideologinya yang kontroversi, punk mempengaruhi dinamika fashion di dunia. Asesoris punk diadaptasi oleh budaya bopuler sebagai pernak-pernik fashion. Kini punk, telah menjadi bagian dari dunia fashion di seluruh dunia. Apa sebenarnya yang melatar belakangi munculnya Punk? bagaimana Punk bisa berkembang di Indonesia? Kata Kunci: punk, fashion, budaya populer

  9. MISKONSEPSI KONSEP ARCHAEBACTERIA DAN EUBACTERIA

    Directory of Open Access Journals (Sweden)

    Fina Nurul Khotimah

    2015-03-01

    Full Text Available Penelitian ini bertujuan untuk mengidentifikasi miskonsepsi siswa pada konsep Archaebacteria dan Eubacteria. Penelitian ini menggunakan metode survei dengan instrumen berupa pilihan ganda beralasan terbuka sebagai alat ukur. Unit analisis dalam penelitian adalah siswa MAN kelas X berjumlah 72 orang. Hasil analisis ditemukan ketidakpahaman pada konsep Archaebacteria dan Eubacteria (61% yang mendominasi kategori lainnya. Sedangkan kategori Paham konsep dan Miskonsepsi hanya sebesar 19% dan 20%. Miskonsepsi yang dialami siswa dari hasil diagnosa alasan terbuka menunjukkan lebih banyak miskonsepsi utuh dibandingkan dengan miskonsepsi sebagian. Miskonsepsi utuh teridentifikasi dengan siswa beranggapan bahwa bakteri lebih banyak menimbulkan kerugian daripada keuntungan bagi manusia dan lingkungan.

  10. Three Mile Island Accident Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Three Mile Island Accident Data consists of mostly upper air and wind observations immediately following the nuclear meltdown occurring on March 28, 1979, near...

  11. Nuclear fuel cycle facility accident analysis handbook

    Energy Technology Data Exchange (ETDEWEB)

    Ayer, J E; Clark, A T; Loysen, P; Ballinger, M Y; Mishima, J; Owczarski, P C; Gregory, W S; Nichols, B D

    1988-05-01

    The Accident Analysis Handbook (AAH) covers four generic facilities: fuel manufacturing, fuel reprocessing, waste storage/solidification, and spent fuel storage; and six accident types: fire, explosion, tornado, criticality, spill, and equipment failure. These are the accident types considered to make major contributions to the radiological risk from accidents in nuclear fuel cycle facility operations. The AAH will enable the user to calculate source term releases from accident scenarios manually or by computer. A major feature of the AAH is development of accident sample problems to provide input to source term analysis methods and transport computer codes. Sample problems and illustrative examples for different accident types are included in the AAH.

  12. Paragliding accidents in remote areas.

    Science.gov (United States)

    Fasching, G; Schippinger, G; Pretscher, R

    1997-08-01

    Paragliding is an increasingly popular hobby, as people try to find new and more adventurous activities. However, there is an increased and inherent danger with this sport. For this reason, as well as the inexperience of many operators, injuries occur frequently. This retrospective study centers on the helicopter rescue of 70 individuals in paragliding accidents. All histories were examined, and 43 patients answered a questionnaire. Nineteen (42%) pilots were injured when taking off, 20 (44%) during the flight, and six (13%) when landing. Routine and experience did not affect the prevalence of accident. Analysis of the causes of accident revealed pilot errors in all but three cases. In 34 rescue operations a landing of the helicopter near the site of the accident was possible. Half of the patients had to be rescued by a cable winch or a long rope fixed to the helicopter. Seven (10%) of the pilots suffered multiple trauma, 38 (54%) had injuries of the lower extremities, and 32 (84%) of them sustained fractures. Injuries to the spine were diagnosed in 34 cases with a fracture rate of 85%. One patient had an incomplete paraplegia. Injuries to the head occurred in 17 patients. No paraglider pilot died. The average hospitalization was 22 days, and average time of working inability was 14 weeks. Fourteen (34%) patients suffered from a permanent damage to their nerves or joints. Forty-three percent of the paragliders continued their sport despite the accident; two of them had another accident. An improved training program is necessary to lower the incidence of paragliding accidents. Optimal equipment to reduce injuries in case of accidents is mandatory. The helicopter emergency physician must perform a careful examination, provide stabilization of airways and circulation, give analgesics, splint fractured extremities, and transport the victim on a vacuum mattress to the appropriate hospital.

  13. Grossesse dans une corne rudimentaire: difficultés diagnostiques et prise en charge thérapeutique

    Science.gov (United States)

    Mamouni, Nisrine; Ghazal, Nabil; Erraghay, Sanaa; Bouchikhi, Chahrazed; Banani, Abdelaziz

    2016-01-01

    La survenue d'une grossesse dans une corne utérine rudimentaire est une situation obstétricale extrêmement rare et potentiellement grave, menaçant le pronostic materno-fœtal. Les auteurs rapportent cinq observations de grossesse dans une corne utérine rudimentaire, à travers lesquelles, ils relatent les difficultés sur le plan diagnostique ainsi que la prise en charge thérapeutique de cette entité pathologique, soulignant l'intérêt de l’échographie endovaginale, de l'IRM pelvienne et de la cœlioscopie dans le diagnostic précoce de ce type de malformation uterine. PMID:27583078

  14. Treatment of severe Graves eye disease%严重Graves眼病的治疗

    Institute of Scientific and Technical Information of China (English)

    吕新生

    2000-01-01

    @@ Graves眼病分型 Graves眼病是一种眼眶内的眼外肌和眶后脂肪结缔组织受累的自身免疫性疾病,是导致眼球突出的常见疾病.Hall等将Graves眼病分为Graves病眼型(Graves' ophthalmopathy)和眼型Graves病(ophthalmopathy Graves' disease,orbital Graves' disease).

  15. Severe accident analysis using dynamic accident progression event trees

    Science.gov (United States)

    Hakobyan, Aram P.

    In present, the development and analysis of Accident Progression Event Trees (APETs) are performed in a manner that is computationally time consuming, difficult to reproduce and also can be phenomenologically inconsistent. One of the principal deficiencies lies in the static nature of conventional APETs. In the conventional event tree techniques, the sequence of events is pre-determined in a fixed order based on the expert judgments. The main objective of this PhD dissertation was to develop a software tool (ADAPT) for automated APET generation using the concept of dynamic event trees. As implied by the name, in dynamic event trees the order and timing of events are determined by the progression of the accident. The tool determines the branching times from a severe accident analysis code based on user specified criteria for branching. It assigns user specified probabilities to every branch, tracks the total branch probability, and truncates branches based on the given pruning/truncation rules to avoid an unmanageable number of scenarios. The function of a dynamic APET developed includes prediction of the conditions, timing, and location of containment failure or bypass leading to the release of radioactive material, and calculation of probabilities of those failures. Thus, scenarios that can potentially lead to early containment failure or bypass, such as through accident induced failure of steam generator tubes, are of particular interest. Also, the work is focused on treatment of uncertainties in severe accident phenomena such as creep rupture of major RCS components, hydrogen burn, containment failure, timing of power recovery, etc. Although the ADAPT methodology (Analysis of Dynamic Accident Progression Trees) could be applied to any severe accident analysis code, in this dissertation the approach is demonstrated by applying it to the MELCOR code [1]. A case study is presented involving station blackout with the loss of auxiliary feedwater system for a

  16. Macapat dan Santiswara

    OpenAIRE

    Darusuprapta, Darusuprapta

    2013-01-01

    Dalam khazanah kebudayaan Indonesia, khusus Jawa, hidup berkembangan kesenian macapat yang disebut juga  macapatan, dan kesenian santiswara yang disebut pula santiswaran. Macapatan lebih mengutamakan pembacaan teks dengan dendangan tembang kemudian diikuti sarasehan atau diskusi yang membahas segala segi isi teks bacaannya, sedangkan santiswaran lebih mengutamakan alunan swara dengan dendangan tembang disertai iringan bunyi tabuh-tabuhan.

  17. DANS LE CONTEXTE IVOIRIEN

    African Journals Online (AJOL)

    LA RELATION "GENRE" ET SES IMPLICATIONS SOCIOLOGIQUES. DANS LE CONTEXTE IVOIRIEN ... de base et de la gestion des affaires publiques en milieu rural .... Les raisons économiques; du fait du faible pouvoir d'achat des parents face au ..... cause de rupture du contrat, toute femme a le droit de suspendre son.

  18. Akromegali Dan Gigantisme

    OpenAIRE

    Silvani, Melati; Pase, M. Aron; Syafril, Santi; Lindarto, Dharma; Solin, Steffie S

    2016-01-01

    Hormon pertumbuhan manusia (Growth Hormone/GH) merupakan peptida rantai tunggal yang terdiri dari 191 asam amino, yang diisolasi dari sel somatotrop pada kelenjar hipofisis anterior pada tahun 1956, dan pertama kali digunakan sebagai terapi untuk penatalaksanaan dwarfisme hipofisis pada tahun 1958. Dwarfisme hipofisis adalah bentuk klasik dari defisiensi hormon pertumbuhan pada anak-anak Melati Silvani

  19. Esclerodermia, tireoidite e miastenia grave: estudo de um caso

    OpenAIRE

    Antonio L. dos Santos Werneck; Tamara Checcacci-Balod; Graça Tuma

    1993-01-01

    Uma paciente de 36 anos com miastenia grave desenvolveu após dois anos intolerância ao frio, o que conduziu ao diagnóstico de tireoidite de Hashimoto. Quatro anos mais tarde apresentou pele espessada nas mãos (esclerodermia limitada). O quadro clínico e os exames complementares encaminharam o diagnóstico para a forma CREST de esclerodermia sistêmica progressiva. Discute-se a dificuldade diagnóstica da esclerodermia, assim como suas síndromes de superposição. Doença de Hashimoto e miastenia gr...

  20. Violencia en la pareja hacia mujeres con transtorno mental grave

    OpenAIRE

    González Cases, Juan Carlos

    2012-01-01

    Este estudio tiene como objetivo principal analizar la prevalencia y características de la violencia de pareja hacia mujeres con un trastorno mental grave. La muestra consta de 142 mujeres mayores de 18 años, que en algún momento de su vida adulta habían tenido una relación de pareja y que estaban en atención en recursos públicos de salud mental de la Comunidad de Madrid. A través de entrevista se aplicaron cuestionarios validados para la medición de violencia psicológica, sexual y física. Ad...

  1. Intoxicación grave por psicofármacos

    Directory of Open Access Journals (Sweden)

    Dr. B. Juan Pablo Acuña

    2011-05-01

    Los objetivos de este artículo son entregar nociones de las manifestaciones clínicas, del manejo inicial y de las complicaciones más frecuentes y graves del intoxicado por ingesta de psicofármacos. Serán agrupados por familia de acuerdo a su clase y uso terapéutico, describiendo los mecanismos de toxicidad. En algunos de ellos hay recomendaciones de consenso respecto del manejo prehospitalario y la derivación a centros de alta complejidad.

  2. Accident tolerant fuel analysis

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Curtis [Idaho National Laboratory; Chichester, Heather [Idaho National Laboratory; Johns, Jesse [Texas A& M University; Teague, Melissa [Idaho National Laboratory; Tonks, Michael Idaho National Laboratory; Youngblood, Robert [Idaho National Laboratory

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced ''RISMC toolkit'' that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional ''accident-tolerant'' (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant

  3. [Accidents of fulguration].

    Science.gov (United States)

    Virenque, C; Laguerre, J

    1976-01-01

    Fulguration, first electric accident in which the man was a victim, is to day better known. A clap of thunder is decomposed in two elements: lightning, and thunder. Lightning is caused by an electrical discharge, either within a cloud, or between two clouds, or, above all, between a cloud and the surface of the ground. Experimental equipments owned by the French Electricity Company and by the Atomic Energy Commission, have allowed to photograph lightnings and to measure certain physical characteristics (Intensity variable between 25 to 100 kA, voltage variable between 20 to 1 000 kV). The frequency of storms was learned: the isokeraunic level, in France, is about 20, meaning that thunder is heard twenty days during one year. Man may be stricken by thunder by direct hit, by sudden bursting, by earth current, or through various conductors. The electric charge which reached him may go to the earth directly by contact with the ground or may dissipate in the air through a bony promontory (elbow). The total number of victims, "wounded" or deceased, is not now known by statistics. Death comes by insulation breakdown of one of several anatomic cephalic formations: skull, meninx, brain. Many various lesions may happen in survivors: loss of consciousness, more or less long, sensorial or motion deficiencies. All these signs are momentary and generally reversible. Besides one may observe much more intense lesions on the skin: burns and, over all, characteristic aborescence (skin effect by high frequency current). The heart is protected, contrarily to what happens with industrial electrocution. The curative treatment is merely symptomatic : reanimation, surgery for burns or associated traumatic lesions. A prevention is researched to help the lonely man, in the country or in the mountains in the houses (lightning conductor, Faraday cage), in vehicles (aircraft, cars, ships). The mysterious and unforseeable character of lightning still stays, leaving a door opened for numerous

  4. Accident Tolerant Fuel Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Curtis Smith; Heather Chichester; Jesse Johns; Melissa Teague; Michael Tonks; Robert Youngblood

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced “RISMC toolkit” that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional “accident-tolerant” (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant decision makers should propose and

  5. Graves' orbitopathy as a rare disease in Europe: a European Group on Graves' Orbitopathy (EUGOGO) position statement.

    Science.gov (United States)

    Perros, P; Hegedüs, L; Bartalena, L; Marcocci, C; Kahaly, G J; Baldeschi, L; Salvi, M; Lazarus, J H; Eckstein, A; Pitz, S; Boboridis, K; Anagnostis, P; Ayvaz, G; Boschi, A; Brix, T H; Currò, N; Konuk, O; Marinò, M; Mitchell, A L; Stankovic, B; Törüner, F B; von Arx, G; Zarković, M; Wiersinga, W M

    2017-04-20

    Graves' orbitopathy (GO) is an autoimmune condition, which is associated with poor clinical outcomes including impaired quality of life and socio-economic status. Current evidence suggests that the incidence of GO in Europe may be declining, however data on the prevalence of this disease are sparse. Several clinical variants of GO exist, including euthyroid GO, recently listed as a rare disease in Europe (ORPHA466682). The objective was to estimate the prevalence of GO and its clinical variants in Europe, based on available literature, and to consider whether they may potentially qualify as rare. Recent published data on the incidence of GO and Graves' hyperthyroidism in Europe were used to estimate the prevalence of GO. The position statement was developed by a series of reviews of drafts and electronic discussions by members of the European Group on Graves' Orbitopathy. The prevalence of GO in Europe is about 10/10,000 persons. The prevalence of other clinical variants is also low: hypothyroid GO 0.02-1.10/10,000; GO associated with dermopathy 0.15/10,000; GO associated with acropachy 0.03/10,000; asymmetrical GO 1.00-5.00/10,000; unilateral GO 0.50-1.50/10,000. GO has a prevalence that is clearly above the threshold for rarity in Europe. However, each of its clinical variants have a low prevalence and could potentially qualify for being considered as a rare condition, providing that future research establishes that they have a distinct pathophysiology. EUGOGO considers this area of academic activity a priority.

  6. Les kystes hydatiques du foie rompus dans les voies biliaires: a propos de 120 cas

    Directory of Open Access Journals (Sweden)

    Mountassir Moujahid

    2011-11-01

    Full Text Available s et une anastomose bilio digestive choledoco duodenale dans 10 cas. La duree moyenne d�hospitalisation etait de 20jours. Nous deplorons deux deces par choc septique et un troisieme par encephalopathie secondaire a une cirrhose biliaire. La morbidite etait representee par huit abces sous phrenique, douze fistules biliaires prolongees et deux occlusions intestinales. Les kystes hydatiques rompus dans les voies biliaires representent la complication la plus grave de cette pathologie benigne. Le traitement repose sur des methodes radicales qui sont d�une efficacite reconnue, mais de realisation dangereuse et les methodes conservatrices, en particulier la deconnexion kysto biliaire qui est une methode simple et qui donne de bons resultas a court et a long terme.

  7. Craniotomia descompressiva bifrontal no tratamento do edema cerebral grave

    Directory of Open Access Journals (Sweden)

    Walter C. Pereira

    1977-06-01

    Full Text Available São apresentados os resultados obtidos com craniotomia descompressiva bifrontal ampla em 12 doentes com edema cerebral grave e irreversível com os métodos convencionais de tratamento, provocado em 10 por traumatismo crânio-encefálico. Todos os pacientes apresentavam quadro neurológico muito grave, com sinais de comprometimento do tronco cerebral superior. Angiografia caro-tídea bilateral foi praticada sistematicamente, tanto no pré como no pós-operatório, constituindo-se no fator decisivo para a indicação cirúrgica. Seis (50% dos doentes sobreviveram, apresentando 5 (41,6% recuperação neurológica e psíquica praticamente totais. Levando em conta estes resultados, consideramos esta técnica cirúrgica o melhor recurso de tratamento em tais casos, máxime se indicada precocemente. São necessários, contudo, cuidados pós-operatórios especiais com estes pacientes, que devem, sempre que possível, ser mantidos em unidade de terapia intensiva, em virtude da grande incidência de complicações, mormente respiratórias.

  8. Clinical update: treatment of hyperthyroidism in Graves' ophthalmopathy.

    Science.gov (United States)

    Azzam, Ibrahim; Tordjman, Karen

    2010-03-01

    The presence of thyroid eye disease (TED) may influence the treatment of hyperthyroidism in patients with Graves' disease. Moreover, treatment of hyperthyroidism may affect the course of Graves' ophthalmopathy (GO). We review the literature and summarise recent knowledge about the impact of treatment modality for hyperthyroidism in GO. Anti-thyroid drugs (ATDs) remain the simplest and safest way to treat hyperthyroidism in patients with GO, but they are associated with a high relapse rate of hyperthyroidism and they have no effect on the course of GO. Radioactive iodine (RAI) treatment may be associated with exacerbation of GO especially in high risk patients, when glucocorticoid prophylaxis may be indicated. Large prospective trials are still lacking to define the exact effect of RAI on the course of GO, particularly in relation to other known risk factors. Likewise, clear guidelines for prophylactic glucocorticoid therapy are needed. RAI should be cautiously used in patients with more severe ophthalmopathy and concomitant I.V glucocorticoids should be considered. Thyroid surgery, whether total or subtotal thyroidectomy, has no effect on the course of ophthalmopathy. However, total thyroid ablation that combines surgery with radioactive iodine, as a means of achieving thyroid antigen disappearance, is increasingly gaining attention for the treatment of patients with GO, especially those undergoing thyroid surgery, but also for those with severe unresponsive ophthalmopathy. Studies supporting this approach are awaited.

  9. Outcomes following surgical decompression for dysthyroid orbitopathy (Graves' disease).

    Science.gov (United States)

    Leong, Samuel C; White, Paul S

    2010-02-01

    Graves' disease is a multiorgan autoimmune disease of complex pathophysiology that primarily affects the thyroid gland and orbit. The ophthalmic manifestations of Graves' disease may vary from mild proptosis which causes minimal cosmetic embarrassment to subluxation of the globe, exposure keratitis, corneal abrasion and even blindness. This article focuses on outcomes following orbital decompression. Surgical techniques have evolved with improved understanding of sinonasal anatomy and being technology-driven with the use of the fiberoptic endoscope and image guidance. The most common surgical outcome reported in the literature is reduction in proptosis, followed by visual acuity and intraocular pressure. Quality-of-life assessments are not routinely measured. There are a myriad of surgical techniques currently in practice which underscores the fact that no single technique is clearly superior to another. Endoscopic decompression results in a mean reduction of 3.50 mm and is associated with a low complication rate. Nevertheless, the literature suggests that the best techniques are likely to be multiwall approaches such as combined medial and lateral wall decompression. Management of dysthyroid ophthalmopathy is clearly multidisciplinary. Future studies should consider a minimum data set for reporting outcome measures which should include a quality of life tool.

  10. Hyperthyroidism in Graves disease. Current trends in management and diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Haibach, H.

    1976-06-01

    The radioimmunoassay for T/sub 3/ is now widely available and is a useful diagnostic tool for hyperthyroidism, especially in T/sub 3/-thyrotoxicosis. It is an essential tool in the management of hyperthyroidism that persists after treatment with normal T/sub 4/ serum levels or, in euthyroid cases, with low T/sub 4/ serum levels. In these conditions, it reflects the metabolic state more accurately than serum levels of T/sub 4/. A promising new test is the response of radioimmunoassayable TSH to protirelin relin (TRH) administration. An absent response indicates pituitary suppression and thyroid autonomy as seen in frank hyperthyroidism or euthyroid Graves disease, treated or untreated. It is safer and quicker than the conventional T/sub 3/ suppression test of thyroid radioactive iodine uptake and may replace it at least partly in the future. The recently recognized sharp decline in the remission rate of patients subjected to thyroid drug therapy in the last decade has made this treatment much less efficacious. By necessity, it will probably lead to greater reliance on treatment with radioactive iodine in the majority of the patients with the hyperthyroidism of Graves disease.

  11. Identicars: uno strumento per migliorare la resa testimoniale nelle indagini per omissione di soccorso stradale/Le système Identicars : un outil pour améliorer la qualité du témoignage dans les enquêtes pour le délit de fuite à la suite d’un accident de la circulation/Identicars system: a tool for improving the quality of witness in the investigations on hit-and-run driving accidents

    Directory of Open Access Journals (Sweden)

    Griggi Manuela

    2017-04-01

    witnesses of hit-and-run driving accidents to recognise the car in question. The researcher’s initial concept is that such a tool should help witnesses to provide more detailed and accurate descriptions. The authors will demonstrate the potential usefulness of the Identicars tool through the results achieved by an experiment carried out at the University of Bologna. These results show a greater accuracy of identification by those witnesses who used the Identicars tool in comparison to those who gave evidence using the traditional method for obtaining the information.

  12. ISLAM DAN RADIKALISME: Upaya Antisipasi dan Penanggulangannya

    Directory of Open Access Journals (Sweden)

    Idrus Ruslan

    2017-02-01

    Full Text Available Sejak tragedi pemboman WTC tanggal 11 September 2001 yang disusul dengan rangkaian peledakan bom di sejumlah negara, banyak orang non Muslim yang berasumsi bahwa ajaran Islam identik dengan radikalisme. Walaupun assumsi yang berkembang itu dapat dimaklumi, namun keyakinan tersebut tentu saja tidak sepenuhnya benar. Karena meskipun terdapat sekelompok orang Islam yang berbuat radikal, akan tetapi mayoritas Muslim justru bertentangan dengan mereka. Lagi pula, jika dicermati secara mendalam, sesungguhnya Islam sama sekali tidak mentolerir tindakan radikal. Ia adalah agama kasih sayang yang sangat mendodrong penganutnya untuk berbuat baik terhadap orang lain, termasuk kepada orang-orang non-Muslim. Artikel ini menawarkan beberapa upaya strategis dalam mengantisipasi dan menanggulangi bahaya radikalisme-terorisme.

  13. Accident knowledge and emergency management

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, B.; Groenberg, C.D.

    1997-03-01

    The report contains an overall frame for transformation of knowledge and experience from risk analysis to emergency education. An accident model has been developed to describe the emergency situation. A key concept of this model is uncontrolled flow of energy (UFOE), essential elements are the state, location and movement of the energy (and mass). A UFOE can be considered as the driving force of an accident, e.g., an explosion, a fire, a release of heavy gases. As long as the energy is confined, i.e. the location and movement of the energy are under control, the situation is safe, but loss of confinement will create a hazardous situation that may develop into an accident. A domain model has been developed for representing accident and emergency scenarios occurring in society. The domain model uses three main categories: status, context and objectives. A domain is a group of activities with allied goals and elements and ten specific domains have been investigated: process plant, storage, nuclear power plant, energy distribution, marine transport of goods, marine transport of people, aviation, transport by road, transport by rail and natural disasters. Totally 25 accident cases were consulted and information was extracted for filling into the schematic representations with two to four cases pr. specific domain. (au) 41 tabs., 8 ills.; 79 refs.

  14. Radioactive materials transport accident analysis

    Energy Technology Data Exchange (ETDEWEB)

    McSweeney, T.I.; Maheras, S.J.; Ross, S.B. [Battelle Memorial Inst. (United States)

    2004-07-01

    Over the last 25 years, one of the major issues raised regarding radioactive material transportation has been the risk of severe accidents. While numerous studies have shown that traffic fatalities dominate the risk, modeling the risk of severe accidents has remained one of the most difficult analysis problems. This paper will show how models that were developed for nuclear spent fuel transport accident analysis can be adopted to obtain estimates of release fractions for other types of radioactive material such as vitrified highlevel radioactive waste. The paper will also show how some experimental results from fire experiments involving low level waste packaging can be used in modeling transport accident analysis with this waste form. The results of the analysis enable an analyst to clearly show the differences in the release fractions as a function of accident severity. The paper will also show that by placing the data in a database such as ACCESS trademark, it is possible to obtain risk measures for transporting the waste forms along proposed routes from the generator site to potential final disposal sites.

  15. Nuclear accident dosimetry intercomparison studies.

    Science.gov (United States)

    Sims, C S

    1989-09-01

    Twenty-two nuclear accident dosimetry intercomparison studies utilizing the fast-pulse Health Physics Research Reactor at the Oak Ridge National Laboratory have been conducted since 1965. These studies have provided a total of 62 different organizations a forum for discussion of criticality accident dosimetry, an opportunity to test their neutron and gamma-ray dosimetry systems under a variety of simulated criticality accident conditions, and the experience of comparing results with reference dose values as well as with the measured results obtained by others making measurements under identical conditions. Sixty-nine nuclear accidents (27 with unmoderated neutron energy spectra and 42 with eight different shielded spectra) have been simulated in the studies. Neutron doses were in the 0.2-8.5 Gy range and gamma doses in the 0.1-2.0 Gy range. A total of 2,289 dose measurements (1,311 neutron, 978 gamma) were made during the intercomparisons. The primary methods of neutron dosimetry were activation foils, thermoluminescent dosimeters, and blood sodium activation. The main methods of gamma dose measurement were thermoluminescent dosimeters, radiophotoluminescent glass, and film. About 68% of the neutron measurements met the accuracy guidelines (+/- 25%) and about 52% of the gamma measurements met the accuracy criterion (+/- 20%) for accident dosimetry.

  16. Evaluación de un programa de intervención familiar en pacientes psicóticos y con trastornos graves de la personalidad.

    Directory of Open Access Journals (Sweden)

    Luz Celia Fernández Martín

    2005-01-01

    Full Text Available El objetivo de este trabajo es evaluar la efectividad de las intervenciones familiares que tienen lugar en una Unidad de Hospitalización Parcial, en pacientes psicóticos en un primer episodio y pacientes con un trastorno de la personalidad, cuyos síntomas son particularmente graves o dan lugar a un notable deterioro de la actividad social o laboral. Además se describe el marco conceptual en que se desenvuelve el tratamiento, los objetivos que se pretenden, así como los procedimientos de la intervención, evaluándose finalmente los resultados al alta en aspectos concretos del tratamiento como relaciones con la familia y con personas ajenas a la misma, asunción y toma de la medicación, actitud frente a la enfermedad o frente al futuro, y actividades de la vida diaria.

  17. La imprescriptibilidad de la accion y la sancion disciplinaria por graves violaciones a los Derechos Humanos e infracciones graves al Derecho Internacional Humanitario

    National Research Council Canada - National Science Library

    Daza-Marquez, Tania-Milena

    2010-01-01

    El articulo presenta un analisis respecto a la problematica de la imprescriptibilidad de la accion y la sancion disciplinarias por graves violaciones e infracciones a los Derechos Humanos y el Derecho...

  18. BAHAYA RADIASI DAN CARA PROTEKSINYA

    Directory of Open Access Journals (Sweden)

    Badunggawa P

    2014-09-01

    Full Text Available Radiasi yang kita terima setiap saat, termasuk radiasi untuk tujuan kedokteran, mempunyai dampak positif dan negatif terhadap keselamatan manusia dan lingkungan. Dampak positif dari radiasi terhadap keselamatan manusia diantaranya adalah digunakan sebagai pengobatan dan dampak negatifnya adalah tergantung dari besar dosis yang diterima diantaranya adalah mulai dari mual, muntah, pusing-pusing, rambut rontok, menyebabkan kanker, diturunkan secara genetik, dan yang lebih berbahaya lagi adalah menyebabkan kematian. Oleh karena itu kita harus berhati-hati terhadap bahaya yang ditimbulkannya, baik terhadap pekerja radiasi maupun masyarakat umum termasuk pasien. Perlindungan terhadap bahaya yang ditimbulkan radiasi ini dikenal dengan istilah proteksi radiasi. Sehingga dosis yang diterima pertahun oleh pekerja atau masyarakat umum tidak melebihi batas dosis yang ditetapkan oleh Bapeten. Berbagai upaya telah dilakukan untuk meminimalkan bahaya tersebut sehingga pekerja dan pasien merasa aman melakukan dan dikenai tindakan medik.[medicina 2009;40:47-51].  

  19. The child accident repeater: a review.

    Science.gov (United States)

    Jones, J G

    1980-04-01

    The child accident repeater is defined as one who has at least three accidents that come to medical attention within a year. The accident situation has features in common with those of the child who has a single accident through simple "bad luck", but other factors predispose him to repeated injury. In the child who has a susceptible personality, a tendency for accident repetition may be due to a breakdown in adjustment to a stressful environment. Prevention of repeat accidents should involve the usual measures considered appropriate for all children as well as an attempt to provide treatment of significant maladjustment and modification of a stressful environment.

  20. Hindsight Bias in Cause Analysis of Accident

    Institute of Scientific and Technical Information of China (English)

    Atsuo Murata; Yasunari Matsushita

    2014-01-01

    It is suggested that hindsight becomes an obstacle to the objective investigation of an accident, and that the proper countermeasures for the prevention of such an accident is impossible if we view the accident with hindsight. Therefore, it is important for organizational managers to prevent hindsight from occurring so that hindsight does not hinder objective and proper measures to be taken and this does not lead to a serious accident. In this study, a basic phenomenon potentially related to accidents, that is, hindsight was taken up, and an attempt was made to explore the phenomenon in order to get basically insights into the prevention of accidents caused by such a cognitive bias.

  1. Sifat Anatomi dan Fisis Kelapa Hibrida

    OpenAIRE

    Hutabarat, Marihot Hamonangan

    2010-01-01

    Penelitian ini bertujuan untuk mengevaluasi sifat anatomis dan fisis batang kelapa hibrida. Ciri anatomi diamati langsung pada sampel dan menggunakan mikroskop untuk pengamatan dimensi seratnya, dan pengujian sifat fisis menggunakan British Standard. Sifat anatomis dan fisis batang kelapa hibrida bervariasi menurut ketinggian dan kedalaman. Struktur anatomis batang kelapa hibrida didominasi oleh vascular bundle dan parenkim. Serat kayu dapat ditemukan didalam vascular bundle dengan rata-r...

  2. Severe accident simulation at Olkiuoto

    Energy Technology Data Exchange (ETDEWEB)

    Tirkkonen, H.; Saarenpaeae, T. [Teollisuuden Voima Oy (TVO), Olkiluoto (Finland); Cliff Po, L.C. [Micro-Simulation Technology, Montville, NJ (United States)

    1995-09-01

    A personal computer-based simulator was developed for the Olkiluoto nuclear plant in Finland for training in severe accident management. The generic software PCTRAN was expanded to model the plant-specific features of the ABB Atom designed BWR including its containment over-pressure protection and filtered vent systems. Scenarios including core heat-up, hydrogen generation, core melt and vessel penetration were developed in this work. Radiation leakage paths and dose rate distribution are presented graphically for operator use in diagnosis and mitigation of accidents. Operating on an graphically for operator use in diagnosis and mitigation of accidents. Operating on an 486 DX2-66, PCTRAN-TVO achieves a speed about 15 times faster than real-time. A convenient and user-friendly graphic interface allows full interactive control. In this paper a review of the component models and verification runs are presented.

  3. Road characteristics and bicycle accidents.

    Science.gov (United States)

    Nyberg, P; Björnstig, U; Bygren, L O

    1996-12-01

    In Umeå, Sweden, defects in the physical road surface contributed to nearly half of the single bicycle accidents. The total social cost of these injuries to people amount to at least SEK 20 million (SEK 60,000 or about USD 8,500 per accident), which corresponds to the estimated loss of "eight life equivalents a year". Improved winter maintenance seems to have the greatest injury prevention potential and would probably reduce the number of injuries considerably, whereas improved road quality and modification of kerbs would reduce the most severe injuries. A local traffic safety program should try to prevent road accidents instead of handling the consequences of them. In accordance with Parliament decisions on traffic we would like to see increased investment in measures favoring bicycle traffic, where cycling is seen as a solution, not as a problem.

  4. Bathtub immersion accidents involving children.

    Science.gov (United States)

    Pearn, J; Nixon, J

    1977-02-12

    A review of 19 consecutive serious bathtub immersion accidents (11 survivals, 8 fatalities) is presented. In all instances, consciousness was lost in the water. Unlike other childhood accidents which usually show a male predominance, the sexes are equally affected. The modal age is 11 months. Six separate causes of bath drownings and near-drownings have been identified, and in 14 of the 19 accidents, two or more causes were operating concurrently. Median estimated immersion time for survivals was four minutes, and five minutes for fatalities. The median depth of water was eight inches. An 'at risk' profile for home bathtub drownings is presented; this includes the youngest or second youngest child of a large family, a family of grade 4 to 7 sociooccupational status (congalton) and a family in which routine is temporarily broken.

  5. Internal Accident Report on EDH

    CERN Multimedia

    SC Department

    2006-01-01

    The A2 Safety Code requires that, the Internal Accident Report form must be filled in by the person concerned or any witness to ensure that all the relevant services are informed. Please note that an electronic version of this form has been elaborated in collaboration with SC-IE, HR-OPS-OP and IT-AIS. Whenever possible, the electronic form shall be used. The relative icon is available on the EDH Desktop, Other tasks page, under the Safety heading, or directly here: https://edh.cern.ch/Document/Accident/. If you have any questions, please contact the SC Secretariat, tel. 75097 Please notice that the Internal Accident Report is an integral part of the Safety Code A2 and does not replace the HS50.

  6. Fukushima accident study using MELCOR

    Institute of Scientific and Technical Information of China (English)

    Randall O Gauntt

    2013-01-01

    The accidents at the Fukushima Daiichi nuclear power station stunned the world as the sequences played out over severals days and videos of hydrogen explosions were televised as they took place.The accidents all resulted in severe damage to the reactor cores and releases of radioactivity to the environment despite heroic measures had taken by the operating personnel.The following paper provides some background into the development of these accidents and their root causes,chief among them,the prolonged station blackout conditions that isolated the reactors from their ultimate heat sink — the ocean.The interpretations given in this paper are summarized from a recently completed report funded by the United States Department of Energy (USDOE).

  7. Nilai Dan Fungsi Ndungndungen Karo

    OpenAIRE

    Rosita Ginting

    2010-01-01

    Tesis ini berjudul “Nilai dan Fungsi Ndungndungen Karo”. Tesis ini menjabarkan tentang macam-macam Ndungndungen Karo, nilai-nilai yang terkandung dalam Ndungndungen Karo, fungsi Ndungndungen Karo, dan bagaimana penggunaan Ndungndungen Karo pada saat sekarang ini. Metode yang dipakai dalam penelitian ini adalah metode deskriptif kualitatif, dengan teknik rekaman dan interviu. Metode kepustakaan juga digunakan dalam penelitian ini karena data sekunder dari penelitian ini adalah data-data ya...

  8. Premature hair greying may predict reduced bone mineral density in Graves' disease.

    LENUS (Irish Health Repository)

    Leary, A C

    2012-02-03

    BACKGROUND: Premature hair greying has been associated with low bone mineral density (BMD), and it may be more frequent in Graves\\' disease. AIMS: To determine whether premature greying is associated with reduced BMD in women with Graves\\' disease and in control women, and to examine whether premature greying is more common in Graves\\' disease. METHODS: Premature greying (> 50% grey by 40 years) and BMD were determined in 44 women with a history of Graves\\' disease and 133 female controls referred for routine BMD measurement. Exclusion criteria included diseases or drugs known to affect BMD. RESULTS: Mean Z and T scores at the lumbar spine were significantly lower (P < 0.04) in subjects with premature greying than in those not prematurely grey among women with Graves\\' disease, but not among control women. Multiple regression confirmed this difference between Graves\\' and control women (P = 0.041). There were no differences at other measurement sites. Of Graves\\' patients, 36% were prematurely grey compared with 25% of control women (P = 0.14). CONCLUSION: Premature greying may be a weak marker for reduced BMD in women with a history of Graves\\' disease, but it is not a marker in normal women.

  9. 75 FR 12377 - Native American Graves Protection and Repatriation Act Regulations-Disposition of Culturally...

    Science.gov (United States)

    2010-03-15

    ... Interior 43 CFR Part 10 Native American Graves Protection and Repatriation Act Regulations-- Disposition of... Part 10 RIN 1024-AD68 Native American Graves Protection and Repatriation Act Regulations--Disposition... rule with request for comments. SUMMARY: This final rule implements the Native American...

  10. 78 FR 27078 - Native American Graves Protection and Repatriation Act Regulations

    Science.gov (United States)

    2013-05-09

    ... Government Relations with Native American Tribal Governments'' (59 FR 22951, April 29, 1994); Executive Order... Office of the Secretary of the Interior 43 CFR Part 10 RIN 1024-AD99 Native American Graves Protection.... SUMMARY: This final rule revises regulations implementing the Native American Graves Protection...

  11. 76 FR 69282 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Science.gov (United States)

    2011-11-08

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native American Graves Protection and... effect the agreed-upon disposition of Native American human remains determined to be...

  12. 75 FR 9429 - Native American Graves Protection and Repatriation Review Committee: Meetings

    Science.gov (United States)

    2010-03-02

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meetings AGENCY... Advisory Committee Act, 5 U.S.C. Appendix (1988), of three meetings of the Native American Graves... agreement, of Native American human remains determined to be culturally unidentifiable; and presentations...

  13. 77 FR 7180 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Science.gov (United States)

    2012-02-10

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Advisory Committee Act, 5 U.S.C. Appendix (1988), of two meetings of the Native American Graves Protection... of Native American human remains determined to be culturally unidentifiable; presentations by...

  14. 77 FR 53228 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Science.gov (United States)

    2012-08-31

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native American Graves..., as required by law, in order to effect the agreed-upon disposition of Native American human...

  15. First reported case of unilateral Graves' disease in the left lobe of a bilobar thyroid gland.

    Science.gov (United States)

    Chen, Louis C; Green, Jennifer B

    2011-06-01

    Unilateral Graves' disease is a rare disease variant that can occur in a bilobar thyroid gland. We report the first documented case of unilateral Graves' disease in the left lobe of a bilobar thyroid gland and review the pertinent literature. A 48-year-old man presented in June 2010 with thyrotoxicosis. I-131 radioisotope uptake was elevated at 33.4%, and scintigraphy revealed that uptake of the radioisotope was uniformly increased in the left lobe of the thyroid gland. Ultrasonography of the thyroid gland revealed a non-nodular, enlarged, and heterogeneous left lobe; Doppler investigation of the lobe showed hypervascularity classically seen in Graves' disease. The right lobe of the thyroid, on the other hand, appeared homogeneous and hypovascular on ultrasonography. Thyroid-stimulating immunoglobulin was significantly elevated at 191% (reference range Graves' disease was the most likely diagnosis. As has occasionally been described in the literature, unilateral involvement of the thyroid gland is a rare presentation of Graves' disease. Pre-existing functional or structural differences (either congenital or acquired) between the two lobes may contribute to this rare presentation. To our knowledge, this is the first reported case of unilateral Graves' disease presenting in the left lobe of a bilobar thyroid gland. Although the pathophysiology of unilateral Graves's disease has not been clearly elucidated, clinicians should be aware that Graves' disease can present unilaterally in either lobe of the thyroid gland.

  16. Early medieval stone-lined graves in Southern Germany: analysis of an emerging noble class.

    Science.gov (United States)

    Rott, Andreas; Turner, Nils; Scholz, Ulrike; von Heyking, Kristin; Immler, Franziska; Peters, Joris; Haberstroh, Jochen; Harbeck, Michaela

    2017-04-01

    Stone-lined graves, which first appear in Bavarian territory during the 7(th) century AD, are assumed to be tombs of emerging nobility. While previous research on stone-lined grave goods supports their status as elite burials, an important factor defining nobility-kinship-has not been examined so far. Morphological analysis of the commingled skeletal remains of 21 individuals from three archaeological sites was carried out. Radiocarbon dating was conducted on these individuals to gain information on usage intervals of these graves. To test whether stone-lined graves can be considered family graves, analyses of mitochondrial HVR I, Y-chromosomal and autosomal STRs were carried out. Morphological examination revealed a surplus of males buried in stone-lined graves and radiocarbon dating points to usage of the tombs for several generations. According to aDNA analysis, kinship can be assumed both between and within stone-lined graves. Taken together, these results hint at burials of family members with high social status being inhumed at the same site, in some cases even the same grave, for several generations. They also suggest, for the first time, that an early medieval linear cemetery was structured according to biological kinship. © 2017 Wiley Periodicals, Inc.

  17. Reduced parietooccipital white matter glutamine measured by proton magnetic resonance spectroscopy in treated graves' disease patients

    DEFF Research Database (Denmark)

    Danielsen, Else Rubæk; Elberling, T.V.; Rasmussen, Åse Krogh

    2008-01-01

    CONTEXT: Graves' disease is an autoimmune disease of the thyroid gland. Patients often have affective and cognitive complaints, whether these disappear after treatment remains disputed. OBJECTIVE: Our objective was to evaluate cerebral biochemistry in acute and treated Graves' disease. DESIGN: We...

  18. Kloning Dan Rekayasa Reproduksi

    Directory of Open Access Journals (Sweden)

    Sulchan Sofoewan

    1997-06-01

    Full Text Available REKAYASA reproduksi yang disebut Assisted Reproductive Techniques (ART atau tehnik tehnik reproduksi dengan tanpa melakukan senggama tetapi dengan bantuan secara medik, atau setiap manipulasi terhadap bagian prekreatif (reproduksi siklus kehidupan. Rekayasa reproduksi, rekayasa genetik dan kloning embrio cenderung untuk saling menunjang (sinergetik. Rekayasa genetik dan klonasi sel embrional dari hasil fertilisasi tadi dapat dilibatkan pada ART sebelum embrio ditransfer kedalam rahim. Untuk pasangan yang suaminya belum memenuhi syarat untuk fertilisasi in vitro karena jumlah spermatozoanya kurang ditempuh dengan cara menyuntikkan spermatozoa langsung kedalam ovum/oosit dengan cara mikro manipulasi/mikro injeksi yang dikenal dengan istilah lCZI (Intracytoplasmic Sperm Injection atau SUZI (Subzonal Sperm Insemination.

  19. En kamp om dans

    DEFF Research Database (Denmark)

    Zachariassen, Annette

    2004-01-01

    Hvordan er det muligt at medtænke et legende og "kæmpende" element i det faglige indholdsområde musik, bevægelse og kropsudtryk/dans? og hvordan er det muligt at lade sig inspirere af elementer fra genren elektric boogie-battel og brasiliansk kampdans "Capoeira" i tilrettelæggelse af et undervisn......Hvordan er det muligt at medtænke et legende og "kæmpende" element i det faglige indholdsområde musik, bevægelse og kropsudtryk/dans? og hvordan er det muligt at lade sig inspirere af elementer fra genren elektric boogie-battel og brasiliansk kampdans "Capoeira" i tilrettelæggelse af et...

  20. The 2016 European Thyroid Association/European Group on Graves' Orbitopathy Guidelines for the Management of Graves' Orbitopathy.

    Science.gov (United States)

    Bartalena, Luigi; Baldeschi, Lelio; Boboridis, Kostas; Eckstein, Anja; Kahaly, George J; Marcocci, Claudio; Perros, Petros; Salvi, Mario; Wiersinga, Wilmar M

    2016-03-01

    Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease, though severe forms are rare. Management of GO is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient's quality of life. Local measures (artificial tears, ointments and dark glasses) and control of risk factors for progression (smoking and thyroid dysfunction) are recommended for all patients. In mild GO, a watchful strategy is usually sufficient, but a 6-month course of selenium supplementation is effective in improving mild manifestations and preventing progression to more severe forms. High-dose glucocorticoids (GCs), preferably via the intravenous route, are the first line of treatment for moderate-to-severe and active GO. The optimal cumulative dose appears to be 4.5-5 g of methylprednisolone, but higher doses (up to 8 g) can be used for more severe forms. Shared decision-making is recommended for selecting second-line treatments, including a second course of intravenous GCs, oral GCs combined with orbital radiotherapy or cyclosporine, rituximab or watchful waiting. Rehabilitative treatment (orbital decompression surgery, squint surgery or eyelid surgery) is needed in the majority of patients when GO has been conservatively managed and inactivated by immunosuppressive treatment.

  1. Perancangan dan Implementasi Modul Praktikum

    Directory of Open Access Journals (Sweden)

    Gita Indah Hapsari

    2015-05-01

    Full Text Available Kemajuan teknologi berbasis komputer berkembang dengan sangat pesat. Seiring dengan perkembangan jaman, kemajuan  tersebut memberikan pengaruh  terhadap  perubahan cara penyampaian pengajaran yang mengarah pada penggunaan jenis media penyampaian. Praktikum merupakan salah satu bentuk pengajaran yang memberikan pengalaman belajar secara nyata terhadap kondisi sebenarnya di lapangan mengenai penggunaan dan implementasi alat praktek yang berhubungan dengan berbagai materi yang dipelajari oleh mahasiswa dan memiliki tujuan untuk memberikan keterampilan dan pengenalan terhadap mahasiswa/peserta didik. Penelitian ini melakukan implementasi teknologi augmented reality terhadap salah satu modul praktikum yaitu pengenalan tata letak hardware dan Port I/O pada motherboard dan bertujuan sebagai alat bantu penyampaian pengajaran praktikum. Pengimplementasian teknologi augmented reality melibatkan aksi oleh user terhadap media penangkapan gambar motherboard menggunakan web camera dan tampilan pemetaan tata letak hardware dan port i/o pada motherboard. Penelitian telah diimplementasikan dan diujicoba terhadap 3 kelas dengan 97 responder. Adapun hasil dari penelitiannya adalah 83% responder menyukai aplikasi, 77% memahami materi, 84,5% menginginkan aplikasi ini menjadi alat bantu ajar, 65,98% meminta materi untuk dilengkapi dan diperbanyak, 77,3% dapat belajar mandiri menggunakan aplikasi ini, tanpa bantuan dari dosen ataupun asisten.

  2. NYERI KEPALA DAN GANGGUAN TIDUR

    Directory of Open Access Journals (Sweden)

    Lina Kamelia

    2014-09-01

    Full Text Available Nyeri kepala dan tidur merupakan dua fenomena yang saling mempengaruhi dengan patomekanisme yang kompleks. Nyeri kepala primer, terutama migren, nyeri kepala klaster dan hypnic headache dapat timbul karena pengurangan waktu tidur, parasomnia, maupun gangguan pada regulasi arsitektur tidur terutama fase rapid eye movement. Sebaliknya, adanya nyeri kepala memicu timbulnya berbagai macam gangguan tidur. Studi pencitraan otak dan biokimia menunjukkan peranan penting melatonin dan nukleus suprachiasmatik   yang mengalami disfungsi pada penderita nyeri kepala yang berhubungan dengan gangguan tidur. [MEDICINA 2013;44:101-104].

  3. SEKS DAN BUGAR

    Directory of Open Access Journals (Sweden)

    Ira Paramastri

    2016-10-01

    Full Text Available Barilah, seorang eksekutif perempuan datang ke klinik psikologi dengan keluhan "malas bahkan tidak terangsang tatkala suaminya mengajak bermain seks", atau keluhan Edo, seorang menejer muda "saya jengkel dengan diri saya sendiri karena saya tidak dapat ereksi dengan keras", atau keluhan pasangan muda wanita karir dan pengusaha Retno-Rubi "saat atau serampung hubungan seksual selalu dibarengi rasa nyeri/sakit, sungguh menyebalkan".

  4. ASIMETRI INFORMASI DAN UNDERPRICING

    Directory of Open Access Journals (Sweden)

    Tety Anggita Safitri

    2013-03-01

    Full Text Available Tujuan penelitian ini adalah untuk menguji pengaruh asimetri informasi terhadap underpricing. Penelitian ini menggunakan sampel 63 perusahaan yang melakukan penawaran umum perdana di Bursa Efek Indonesia dalam kurun waktu 2005-2010. Analisis data menggunakan regresi linier berganda, yaitu menguji proksi asimetri informasi yang terdiri atas ukuran perusahaan, umur perusahaan, proporsi saham yang ditawarkan kepada masyarakat, reputasi underwriter dan reputasi auditor terhadap underpricing. Hasil penelitian ini mengindikasikan bahwa reputasi underwriter dan reputasi auditor berpengaruh terhadap underpricing. Ukuran perusahaan, umur perusahaan dan proporsi saham yang ditawarkan tidak berpengaruh terhadap underpricing.The aim of this research is to examine the effect of assymetric information on underpricing. This research used a sample of 63 companies that make initial public offering on the Indonesia Stock Exchange in the period of 2005-2010. The data analysis is using multiple linear regression, which is testing the proxy of asymmetric information which consists of the firm size, the firm age, the proportion of shares offered to the public, underwriter reputation and auditor reputation on underpricing. This research indicates that underwriter reputation and auditor reputation have a significant effect on underpricing. The firm size, the firm age and the proportion of shares offered to the public have no significant effect on underpricing.

  5. ASIMETRI INFORMASI DAN UNDERPRICING

    Directory of Open Access Journals (Sweden)

    Tety Anggita Safitri

    2013-03-01

    Full Text Available Tujuan penelitian ini adalah untuk menguji pengaruh asimetri informasi terhadap underpricing. Penelitian ini menggunakan sampel 63 perusahaan yang melakukan penawaran umum perdana di Bursa Efek Indonesia dalam kurun waktu 2005-2010. Analisis data menggunakan regresi linier berganda, yaitu menguji proksi asimetri informasi yang terdiri atas ukuran perusahaan, umur perusahaan, proporsi saham yang ditawarkan kepada masyarakat, reputasi underwriter dan reputasi auditor terhadap underpricing. Hasil penelitian ini mengindikasikan bahwa reputasi underwriter dan reputasi auditor berpengaruh terhadap underpricing. Ukuran perusahaan, umur perusahaan dan proporsi saham yang ditawarkan tidak berpengaruh terhadap underpricing.The aim of this research is to examine the effect of assymetric information on underpricing. This research used a sample of 63 companies that make initial public offering on the Indonesia Stock Exchange in the period of 2005-2010. The data analysis is using multiple linear regression, which is testing the proxy of asymmetric information which consists of the firm size, the firm age, the proportion of shares offered to the public, underwriter reputation and auditor reputation on underpricing. This research indicates that underwriter reputation and auditor reputation have a significant effect on underpricing. The firm size, the firm age and the proportion of shares offered to the public have no significant effect on underpricing.

  6. Padrao epidemiologico das oclusopatias muito graves em adolescentes brasileiros

    Directory of Open Access Journals (Sweden)

    Karen Glazer Peres

    2013-12-01

    Full Text Available OBJETIVO: Descrever o padrão de distribuição das oclusopatias em adolescentes brasileiros e identificar fatores associados a esse agravo bucal. MÉTODOS: Foram analisados dados de 7.328 e 5.445 adolescentes de 12 e 15-19 anos, respectivamente, participantes da Pesquisa Nacional de Saúde Bucal (SBBrasil 2010. O desfecho foi oclusopatia muito grave segundo o índice de estética dental. As variáveis de exposição foram sexo, cor da pele, renda familiar mensal, número de bens, aglomeração no domicílio, cárie não tratada, perda dentária, uso, frequência e motivo da consulta odontológica. Foram conduzidas análises de regressão logística considerando a complexidade do desenho amostral, com base em modelo hierarquizado. RESULTADOS: Prevalência de oclusopatia muito grave foi observada em 6,5% e 9,1% nos jovens de 12 e 15-19 anos, respectivamente. Após análise ajustada, a chance do desfecho foi 1,59 (IC95% 1,08;2,34 vez maior nos pardos e pretos em relação aos brancos e 2,66 (IC95% 1,26;5,63 vezes maior dentre aqueles com perda de pelo menos um primeiro molar aos 12 anos. Jovens de 15-19 anos cuja renda familiar mensal foi de até R$ 1.500,00 (OR 2,69 [IC95% 1,62;4,47] e aqueles que consultaram o dentista para tratamento (OR 2,59 [IC95% 2,55;4,34] apresentaram maior chance de oclusopatia muito grave quando comparados aos de maior renda e que procuraram o dentista para prevenção. CONCLUSÕES: A distribuição das oclusopatias em adolescentes brasileiros segue o padrão de iniquidade social de outros agravos à saúde. Essas informações são úteis para a formulação de critérios relacionados tanto com a distribuição e provisão de recursos quanto com as prioridades de tratamento ortodôntico fundamentados no princípio da equidade da atenção à saúde bucal.

  7. DIVERSITAS DAN KERAPATAN MANGROVE, GASTROPODA DAN BIVALVIA DI ESTUARI PERANCAK, BALI

    OpenAIRE

    2011-01-01

    Penelitian ini bertujuan membandingkan diversitas dan kerapatan mangrove dengan kepadatan gastropoda dan bivalvia di mangrove alami dan rehabilitasi. Pengukuran ekosistem mangrove menggunakan transek kuadrat 10 m x 10 m. Kelimpahan dan kepadatan gastropoda dan bialvia menggunakan transek kuadrat berukuran 1 m x 1 m. Analisis nMDS, cluster untuk melihat hubungan karekteristik mangrove alami dan rehabilitasi dianalisis secara deskriptif dan analisis regresi untuk mendetermi...

  8. How to reduce the number of accidents

    CERN Multimedia

    2012-01-01

    Among the safety objectives that the Director-General has established for CERN in 2012 is a reduction in the number of workplace accidents.   The best way to prevent workplace accidents is to learn from experience. This is why any accident, fire, instance of pollution, or even a near-miss, should be reported using the EDH form that can be found here. All accident reports are followed up. The departments investigate all accidents that result in sick leave, as well as all the more common categories of accidents at CERN, essentially falls (slipping, falling on stairs, etc.), regardless of whether or not they lead to sick leave. By studying the accident causes that come to light in this way, it is possible to take preventive action to avoid such accidents in the future. If you have any questions, the HSE Unit will be happy to answer them. Contact us at safety-general@cern.ch. HSE Unit

  9. IJTIHAD KONTEMPORER (Problem dan Solusinya

    Directory of Open Access Journals (Sweden)

    Mustaqim Mustaqim

    2011-04-01

    Full Text Available Ijtiha>d adalah merupakan bahasan yang tak henti-hentinya menjadi kajian ketat para ulama sejak dulu sampai kini, seperti imam al-Ghaza>li> membahas dalam bukunya al mustasfa, demikian juga imam assyaukani membahas dalam bukunya irsyadul puhul dan masih banyak lagi ulama yung membahas dalam masalah ijtiha>d ini, Begitu juga dari kalangan ulama kontemporer seperti, Shaykh Ah}mad Ibra>hi>m, Shaykh ‘Abd al-Wahha>b Khala>f, Dr. Yu>suf al-Qarad}awi>, Dr. T{a>ha> Jabi>r dan masih banyak lagi selain mereka. Bersama itu, pintu ijtiha>d tak pernah tertutup, karena kehidupan masih terus berlanjut, dan kejadian-kejadian masih terus berkembang, timbulnya krisis ekonomi dan sosial, rangkaian masalah dan berbagai macam solusinya, desakan kejadian yang tak pernah dipersiapkan oleh manusia yang menimbulkan aneka ragam kesulitan, dan terus mengakar sampai menyelami kehidupan tekhnologi, perdagangan, atau kehidupan individu dan umum. Berawal dari sini maka merupakan cambuk bagi seorang muslim dengan kebebasan berpikirnya untuk mengerahkan segala kemampuannya terhadap seluruh masalah, sebab islam adalah agama kehidupan yang mencakup segala aspek, Islam bukan hanya berurusan dengan masalah akhirat saja, tapi Islam lahir dalam bentuk yang luas, mampu mengobati penyakit sosial, ekonomi, internasional, dll, dan fiqih sendiri bukan hanya merupakan peraturan belaka, melainkan fiqih mencakup segala masalah tergantung kejadian dan kebutuhan, fiqih masih siap menerima perubahan selama masih tetap dalam rel qur’an dan sunnah, dari sinilah perlu adanya ijtiha>d, Ijtiha>d merupakan hal yang terbuka bagi seorang muslim agar merasakan kebebasan berfikir yang sempurna karena ijtiha>d adalah merupakan sebuah bukti akan luas dan mudahnya syariat islam.

  10. [The necklace from the 660 grave in Megara Iblea].

    Science.gov (United States)

    Verger, Stéphane

    2011-01-01

    The article analyzes the 660 grave in Megara Iblea, a Greek colony in Sicily, in which a woman has been buried. On her breast a magnificent neckless was found, made of amulets recalling the travel of the sun during the summer solstice. Some objects allude to solar cults (a cock; round pendants), others seem to came from Gallia and Macedonia (summer far West and East), others recall archeological contexts such as tombs in Marvinci, in the Vardar Valley, and allude to relations with female practices of medicine and magic and to female roles characterized by extraordinary powers, due to being descendants of the Sun god. These solar symbols, joint with the discovery of many little objects, typical of children burials, allow to hypotize a relation with the cult of Mater Matuta and seem to point out a difficult or anomalous pregnancy or birth.

  11. Doença Pariodontal: fator associado à asma grave?

    OpenAIRE

    Marques, Kaliane Rocha Soledade

    2012-01-01

    A periodontite constitui-se uma doença crônica de grande prevalência na população, com repercussões imunológicas em todo o organismo. Estima-se que a periodontite pode influenciar na hiper-resposta inflamatória em indivíduos com asma, por meio de alterações imuno-inflamatórias, além de servirem como fontes de microrganismos para o desenvolvimento de infecções pulmonares. Objetivo: Avaliar a possível associação entre a presença periodontite e a asma grave. Método: Estudo caso-co...

  12. The story of the only (? megalith grave on Gotland Island

    Directory of Open Access Journals (Sweden)

    Helene Martinsson-Wallin

    2010-12-01

    Full Text Available In this paper, we discuss the easternmost material expression of the Funnel Beaker Culture – a megalith grave on the west coast of Gotland Island in the Baltic Sea. The people who built and used the megalith brought the Neolithic lifestyle to Gotland. The biography of this monument includes two excavations, of which we participated in the latest in 1984. Our osteological analysis confirms that some thirty individuals of both sexes and various ages were buried there. The structure of the monument is that of a rectangular dolmen. This paper discusses the discovery of this specific site, and explores the existence of this type of monument in a Gotland context. Furthermore, is this really the only megalith on Gotland, or are more of these structures yet to be recognised? Finally, one may ask if the Neolithic way of life really was successful on Gotland.

  13. Changes of Regulatory T Cells in Graves' Disease

    Institute of Scientific and Technical Information of China (English)

    WANG Hongxiang; ZHAO Shi; TANG Xiaoqiong; LI Jingyuan

    2006-01-01

    The immune mechanism of Graves' diseases (GD) and the roles of regulator T cells were investigated. In 32 patients with GD (GD group) and 20 healthy volunteers (control group), flow cytometry was used to detect the proportion of CD4+CD25+ cells, MACS to isolate CD4+ CD25+ cells,RT-PCR to assay the expression of FOXP3, and ELISA to test the level of IL-10, respectively. It was found that there was no significant change in the proportion of CD4+CD25+ T cells between GD group and control group (P>0.05), while secretion of IL-10 and expression of FOXP3 in GD group were lower than control group (P<0.01 and P<0.05, respectively). In conclusion, though the proportion of regulatory T cells of peripheral blood lymphocytes in the patients with GD, the functions of them were significantly weakened, which might be a pathogenic factor in GD.

  14. Doenças da tireoide e miastenia grave

    OpenAIRE

    1984-01-01

    Os autores estudam o comportamento da tireóide em um grupo de 304 pacientes com miastenia grave, constatando 15 casos de tireopatias, sendo 9 de hipertireoidismo, um de hipotireoidismo e 5 de bócio sem alterações da função tireoidiana. Nenhum paciente era proveniente de região de bócio endêmico e não havia bócio familiar. A tireotoxicose, que foi a disfunção mais frequente, foi estudada quanto a sua prevalência em pacientes miastênicos, quanto a sua influência sobre os sintomas da miastenia g...

  15. Management plan and delivery of care in Graves' ophthalmopathy patients.

    Science.gov (United States)

    Yang, Morgan; Perros, Petros

    2012-06-01

    Most patients with Graves' orbitopathy have mild disease that requires no or minimal intervention. For the minority of patients with moderate or severe disease, multiple medical and surgical treatments may be required at different stages. It is crucial that such patients are monitored closely and treatments applied with care in the right sequence. Medical treatments should be used as early as possible and only during the active phase of the disease. Rehabilitative surgery is indicated in the inactive phase of the disease and should follow the sequence: surgical decompression followed by eye muscle surgery, followed by lid surgery. Delivery of care in a coordinated fashion that makes use of best available expertise is important and best implemented through a Combined Thyroid Eye clinic.

  16. Impacto de la "Ley de promoción de la autonomía personal y atención a las personas en situación de dependencia" en las personas con trastorno mental grave.

    Directory of Open Access Journals (Sweden)

    Teodosia Sobrino Calzado

    2012-01-01

    Full Text Available La Ley 39/2006, conocida como Ley de Dependencia, ha generado, desde su aprobación, desconfianza por estar orientada a la atención de la dependencia, siendo la promoción de la autonomía personal un elemento apenas desarrollado y secundario.
    En el caso de las personas con trastorno mental grave, lo que mayor preocupación ha causado a las organizaciones de profesionales de la salud mental y a las asociaciones de familiares ha sido la compatibilidad de dicha Ley con las prestaciones del Sistema Nacional de Salud y si el baremo establecido se ajustaba a las necesidades de este colectivo.
    Este artículo recoge el trabajo realizado desde diferentes comunidades autónomas por diferentes profesionales en un intento de, tras un análisis de la Ley, plantear a la administración responsable de la misma el necesario ajuste para adaptarla a las características de las personas con trastorno mental grave.
    Se analizan, en primer lugar, sus fortalezas y debilidades. Posteriormente se exponen tres formas diferentes de contrarrestar sus riesgos, en tres comunidades autónomas diferentes. Finalmente se dan las claves de los aspectos de la Ley sobre los que hay que seguir trabajando para que sea una oportunidad para las personas con trastorno mental grave, y no una barrera

  17. Trismus: An unusual presentation following road accident

    Directory of Open Access Journals (Sweden)

    Thakur Jagdeep

    2007-01-01

    Full Text Available Trismus due to trauma usually follows road accidents leading to massive faciomaxillary injury. In the literature there is no report of a foreign body causing trismus following a road accident, this rare case is an exception. We present a case of isolated presentation of trismus following a road accident. This case report stresses on the thorough evaluation of patients presenting with trismus following a road accident.

  18. The Physics of Traffic Accidents

    Science.gov (United States)

    Knight, Peter

    1975-01-01

    Shows how physics can be used to analyze and prevent traffic accidents by determining critical speeds on curves, the behavior of motor cycles and stability of articulated vehicles, and the visibility that is needed to make a minor road junction safe. (MLH)

  19. Work Accidents and Professional Diseases

    Directory of Open Access Journals (Sweden)

    Doru Hauptmann

    2009-10-01

    Full Text Available The major accident is defined as “any event occurred, like an emission of dangerous materials or agents, which emerges from uncontrolled evolutions along the exploitation of any objective that leads to the immediate or delayed occurrence of serious dangers with impact over human health or over the environment, inside or outside the objective in which are involved one or more than one dangerous materials”.The dangerous phenomenon is a potential source of harms. In the ambit of industrial risks of accidental origins, this expression more frequently refers to physical phenomena like conflagrations, explosions, toxic gases dispersion, etc.Any accident scenario relates itself to the potential effects at the level of environmental “targets”. In the case of major accidents, we can distinguish the following categories of “targets”: human (employees of the objective, working or resident people in the nearby of the emplacement; the installation or equipments that may stay at the origin of the accidents (dangerous equipments; certain all-important equipments to ensure the safety level of the installation (critical security equipments: control rooms, civil fire brigade headquarters, etc; goods and structures situated in the installation’ environment (ground water, rivers, soil, flora, fauna.

  20. New technology for accident prevention

    Energy Technology Data Exchange (ETDEWEB)

    Byne, P. [Shiftwork Solutions, Vancouver, BC (Canada)

    2006-07-01

    This power point presentation examined the effects of fatigue in the workplace and presented 3 technologies designed to prevent or monitor fatigue. The relationship between mental fatigue, circadian rhythms and cognitive performance was explored. Details of vigilance related degradations in the workplace were presented, as well as data on fatigue-related accidents and a time-line of meter-reading errors. It was noted that the direct cause of the Exxon Valdez disaster was sleep deprivation. Fatigue related accidents during the Gulf War were reviewed. The effects of fatigue on workplace performance include impaired logical reasoning and decision-making; impaired vigilance and attention; slowed mental operations; loss of situational awareness; slowed reaction time; and short cuts and lapses in optional or self-paced behaviours. New technologies to prevent fatigue-related accidents include (1) the driver fatigue monitor, an infra-red camera and computer that tracks a driver's slow eye-lid closures to prevent fatigue related accidents; (2) a fatigue avoidance scheduling tool (FAST) which collects actigraphs of sleep activity; and (3) SAFTE, a sleep, activity, fatigue and effectiveness model. refs., tabs., figs.

  1. Corporate Cost of Occupational Accidents

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.; Impgaard, M.

    2004-01-01

    The systematic accident cost analysis (SACA) project was carried out during 2001 by The Aarhus School of Business and PricewaterhouseCoopers Denmark with financial support from The Danish National Working Environment Authority. Its focused on developing and testing a method for evaluating...

  2. Crime, accidents and social control

    NARCIS (Netherlands)

    Junger, Marianne; Terlouw, Gert-Jan; van der Heijden, Peter G.M.

    1995-01-01

    This paper addresses to questions. (1) Is there a demonstrable relation between accidents and crime, does this relation hold for each type of crime and each means of transport, and does it subsist after controlling for age and gender? (2) Can social control theory explain involvements in both

  3. Detection and analysis of accident black spots with even small accident figures.

    NARCIS (Netherlands)

    Oppe, S.

    1982-01-01

    Accident black spots are usually defined as road locations with high accident potentials. In order to detect such hazardous locations we have to know the probability of an accident for a traffic situation of some kind, or the mean number of accidents for some unit of time. In almost all procedures

  4. Detection and analysis of accident black spots with even small accident figures.

    NARCIS (Netherlands)

    Oppe, S.

    1982-01-01

    Accident black spots are usually defined as road locations with high accident potentials. In order to detect such hazardous locations we have to know the probability of an accident for a traffic situation of some kind, or the mean number of accidents for some unit of time. In almost all procedures

  5. Association between polymorphisms in the TSHR gene and Graves' orbitopathy.

    Directory of Open Access Journals (Sweden)

    Beata Jurecka-Lubieniecka

    Full Text Available BACKGROUND: Graves' orbitopathy (GO as well as Graves' disease (GD hyperthyroidism originate from an autoimmune reaction against the common auto-antigen, thyroid-stimulating hormone receptor (TSHR. GO phenotype is associated with environmental risk factors, mainly nicotinism, as well as genetic risk factors which initiate an immunologic reaction. In some patients GO is observed before diagnosis of GD hyperthyroidism, while it can also be observed far after diagnosis. The intensity of GO symptoms varies greatly in these patients. Thus, the pathogenesis of GD and GO may correlate with different genetic backgrounds, which has been confirmed by studies of correlations between GO and polymorphisms in cytokines involved in orbit inflammation. The aim of our analysis was to assess genetic predisposition to GO in young patients (age of diagnosis ≤30 years of age, for whom environmental effects had less time to influence outcomes than in adults. METHODS: 768 GD patients were included in the study. 359 of them had clinically evident orbitopathy (NOSPECS ≥2. Patients were stratified by age at diagnosis. Association analyses were performed for genes with a known influence on development of GD - TSHR, HLA-DRB1, cytotoxic T-lymphocyte antigen 4 (CTLA4 and lymphoid protein tyrosine phosphatase (PTPN22. RESULTS: The rs179247 TSHR polymorphism was associated with GO in young patients only. In young GO-free patients, allele A was statistically more frequent and homozygous carriers had a considerable lower risk of disease incidence than patients with AG or GG genotypes. Those differences were not found in either elderly patients or the group analyzed as a whole. CONCLUSIONS: Allele A of the rs179247 polymorphism in the TSHR gene is associated with lower risk of GO in young GD patients.

  6. Atypical Clinical Manifestations of Graves' Disease: An Analysis in Depth

    Directory of Open Access Journals (Sweden)

    Mohamed Osama Hegazi

    2012-01-01

    Full Text Available Over the past few decades, there has been an increase in the number of reports about newly recognized (atypical or unusual manifestations of Graves' disease (GD, that are related to various body systems. One of these manifestations is sometimes the main presenting feature of GD. Some of the atypical manifestations are specifically related to GD, while others are also similarly seen in patients with other forms of hyperthyroidism. Lack of knowledge of the association between these findings and GD may lead to delay in diagnosis, misdiagnosis, or unnecessary investigations. The atypical clinical presentations of GD include anemia, vomiting, jaundice, and right heart failure. There is one type of anemia that is not explained by any of the known etiological factors and responds well to hyperthyroidism treatment. This type of anemia resembles anemia of chronic disease and may be termed GD anemia. Other forms of anemia that are associated with GD include pernicious anemia, iron deficiency anemia of celiac disease, and autoimmune hemolytic anemia. Vomiting has been reported as a presenting feature of Graves' disease. Some cases had the typical findings of hyperthyroidism initially masked, and the vomiting did not improve until hyperthyroidism has been detected and treated. Hyperthyroidism may present with jaundice, and on the other hand, deep jaundice may develop with the onset of overt hyperthyroidism in previously compensated chronic liver disease patients. Pulmonary hypertension is reported to be associated with GD and to respond to its treatment. GD-related pulmonary hypertension may be so severe to produce isolated right-sided heart failure that is occasionally found as the presenting manifestation of GD.

  7. Intersection layout, traffic volumes and accidents.

    NARCIS (Netherlands)

    Poppe, F.

    1988-01-01

    This paper reports on the accident research carried out as a part of a large project started in 1983. For this accident research an inventory was made of a large number of intersections.Recorded were layout features, accident data and estimates of traffic volumes. Attention will be given to the

  8. 48 CFR 836.513 - Accident prevention.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Accident prevention. 836... prevention. The contracting officer must insert the clause at 852.236-87, Accident Prevention, in solicitations and contracts for construction that contain the clause at FAR 52.236-13, Accident Prevention....

  9. 48 CFR 1836.513 - Accident prevention.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Accident prevention. 1836... 1836.513 Accident prevention. The contracting officer must insert the clause at 1852.223-70, Safety and Health, in lieu of FAR clause 52.236-13, Accident Prevention, and its Alternate I....

  10. 48 CFR 636.513 - Accident prevention.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Accident prevention. 636... CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 636.513 Accident prevention. (a) In... contracting activities shall insert DOSAR 652.236-70, Accident Prevention, in lieu of FAR clause...

  11. Barriers to learning from incidents and accidents

    NARCIS (Netherlands)

    Dechy, N.; Dien, Y.; Drupsteen, L.; Felicio, A.; Cunha, C.; Roed-Larsen, S.; Marsden, E.; Tulonen, T.; Stoop, J.; Strucic, M.; Vetere Arellano, A.L.; Vorm, J.K.J. van der; Benner, L.

    2015-01-01

    This document provides an overview of knowledge concerning barriers to learning from incidents and accidents. It focuses on learning from accident investigations, public inquiries and operational experience feedback, in industrial sectors that are exposed to major accident hazards. The document disc

  12. Enhanced thyroid iodine metabolism in patients with triiodothyronine-predominant Graves' disease

    Energy Technology Data Exchange (ETDEWEB)

    Takamatsu, J.; Hosoya, T.; Naito, N.; Yoshimura, H.; Kohno, Y.; Tarutani, O.; Kuma, K.; Sakane, S.; Takeda, K.; Mozai, T.

    1988-01-01

    Some patients with hyperthyroid Graves' disease have increased serum T3 and normal or even low serum T4 levels during treatment with antithyroid drugs. These patients with elevated serum T3 to T4 ratios rarely have a remission of their hyperthyroidism. The aim of this study was to investigate thyroid iodine metabolism in such patients, whom we termed T3-predominant Graves' disease. Mean thyroid radioactive iodine uptake was 51.0 +/- 18.1% ( +/- SD) at 3 h, and it decreased to 38.9 +/- 20.1% at 24 h in 31 patients with T3-predominant Graves' disease during treatment. It was 20.0 +/- 11.4% at 3 h and increased to 31.9 +/- 16.0% at 24 h in 17 other patients with hyperthyroid Graves' disease who had normal serum T3 and T4 levels and a normal serum T3 to T4 ratio during treatment (control Graves' disease). The activity of serum TSH receptor antibodies was significantly higher in the patients with T3-predominant Graves' disease than in control Graves' disease patients. From in vitro studies of thyroid tissue obtained at surgery, both thyroglobulin content and iodine content in thyroglobulin were significantly lower in patients with T3-predominant Graves' disease than in the control Graves' disease patients. Thyroid peroxidase (TPO) activity determined by a guaiacol assay was 0.411 +/- 0.212 g.u./mg protein in the T3-predominant Graves' disease patients, significantly higher than that in the control Graves' disease patients. Serum TPO autoantibody levels determined by immunoprecipitation also were greater in T3-predominant Graves' disease patients than in control Graves' disease patients. Binding of this antibody to TPO slightly inhibited the enzyme activity of TPO, but this effect of the antibody was similar in the two groups of patients.

  13. Analysing truck position data to study roundabout accident risk

    OpenAIRE

    Kamla, Jwan Jameel Shekh Mohammed

    2016-01-01

    In order to reduce accident risk, highway authorities prioritise maintenance budgets partly based upon previous accident history. However, as accident rates have continued to fall in most contexts, this approach has become problematic as accident ‘black spots’ have been treated and the number of accidents at any individual site has fallen. Another way of identifying sites of higher accident risk might be to identify near-miss accidents (where an accident nearly happened, but was avoided), whi...

  14. A numerical study on a lumped-parameter model and a CFD code coupling for the analysis of the loss of coolant accident in a reactor containment; Etude numerique 0D-multiD pour l'analyse de perte de refrigerant dans une enceinte de confinement d'un reacteur nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Y.J.

    2005-12-15

    In the case of PWR severe accident (Loss of Coolant Accident, LOCA), the inner containment ambient properties such as temperature, pressure and gas species concentrations due to the released steam condensation are the main factors that determine the risk. For this reason, their distributions should be known accurately, but the complexity of the geometry and the computational costs are strong limitations to conduct full three-dimensional numerical simulations. An alternative approach is presented in this thesis, namely, the coupling between a lumped-parameter model and a CFD. The coupling is based on the introduction of a 'heat transfer function' between both models and it is expected that large decreases in the CPU-costs may be achieved. First of all, wall condensation models, such as the Uchida or the Chilton-Colburn models which are implemented in the code CAST3M/TONUS, are investigated. They are examined through steady-state calculations by using the code TONUS-0D, based on lumped parameter models. The temperature and the pressure within the inner containment are compared with those reported in the archival literature. In order to build the 'heat transfer function', natural convection heat transfer is then studied by using the code CAST3M for a partitioned cavity which represents a simplified geometry of the reactor containment. At a first step, two-dimensional natural convection heat transfer without condensation is investigated only. Either the incompressible-Boussinesq fluid flow model or the asymptotic low Mach model are considered for solving the time dependent conservation equations. The SUPG finite element method and the implicit scheme are applied for the numerical discretization. The computed results are qualified by the second-order Richardson extrapolation method which allows obtaining the so-called 'Exact values', i.e. grid size independent values. The computations are also validated through non-partitioned cavity case

  15. Analisis dan Optimasi Desain Sistem Reaktor Gas Temperatur Tinggi RGTT200K dan RGTT200KT

    Directory of Open Access Journals (Sweden)

    Mohammad Dhandhang Purwadi

    2013-03-01

    dengan penyelesaian persamaan aljabar linier dari model RGTT200K dan RGTT200KT. Dari analisis dan optimasi ini dihasilkan desain konseptual sistem RGTT200K dan RGTT200KT dengan spesifikasi thermal-flow teras sama, dan peningkatan EUF dari 63% menjadi 80,14% (untuk RGTT200K dan dari 63,6% menjadi 78,02% (untuk RGTT200KT.

  16. The Role of Oxidative Stress on the Pathogenesis of Graves' Disease

    Directory of Open Access Journals (Sweden)

    Miloš Žarković

    2012-01-01

    Full Text Available Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed “oxidative stress” (OS. Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1 involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo.

  17. Exfoliative Cheilitis dan Penatalaksanaannya

    Directory of Open Access Journals (Sweden)

    Dewi Agustina

    2012-12-01

    Full Text Available Latar Belakang: Exfoliative cheilitis adalah suatu keadaan inflamatori kronis superfisisal yang ditandai dengan adanya pengelupasan permukaankeratin bibir sedangkan area yang lain terjadi pembentukan lapisan keratin. Tujuan: untuk melaporkan suatu  kasus Exfoliative cheilitis yang diikuti +  selama 2 bulan beserta penatalaksanaanya. Laporan kasus: seorang wanita berusia 52 tahun mengeluh bibir bawahnya pecah-pecah, terasa kering dan panas berdasarkan pemeriksaan subyektif dan klinis, Exfoliative cheilitis ditetapkan sebagai diagnosis kerja. Penatalaksanaanya: Komunikasi-Informasi-Edukasi (KIE diberikan kepada pasien pada awal kunjungan disertai pemberian metil prednisolon, Vitamin B1,6,12 dan anjuran untuk menghentikan kebiasaan menjilat-jilat bibir bawah, menghindari stress dan meningkatkan asupan makanan yang mengandung vitamin A. Pada kunjungna berikutnya pemberian metil prednisolon dihentikan karena terdeteksi adanya peningkatan tekanan darah. Untuk selanjutnya kondisi bibir bawah dievaluasi +  selama 2 bulan. Kesimpulan: Progresitas Exfoliative cheilitis dapat dihentikan dengan bantuan KIE serta menghindari faktor pemicu stress, yang pada akhirnya akan dapat meminimalisir aktivitas factitious berupa menjilat-jilat bibir bawah.    Background: Exfoliative cheilitis is a chronic superficial inflammatory condition that is characterized by regular peeling of a superficial excessive layer of karatin, on the other hand, keratinization is developed in the other area. Aim: to report an Exfoliative cheilitis case monitored for two months and its management. Case Report: a 52 year female has been suffering from fissured lower lip with dry and burning sensations. According to subjective and clinical examinations, Exfoliative cheilitis was determined as the working diagnosis. Management: Communication-Information-Education (CIE were given to the patient at the first visit, besides metyl prednisolon and vitamin B1,6,12 administrations. Patient was

  18. [Hanggliding accidents. Distribution of injuries and accident analysis].

    Science.gov (United States)

    Ballmer, F T; Jakob, R P

    1989-12-01

    Paragliding--a relatively new sport to Switzerland--brought 23 patients with 48 injuries (38% lower limb and 29% spinal) within a period of 8 months to the Inselspital University hospital in Berne. The aim of the study in characterizing these injuries is to formulate some guidelines towards prevention. With over 90% of accidents occurring at either take off or landing, emphasis on better training for the beginner is proposed with strict guidelines for the more experienced pilot flying in unfavourable conditions.

  19. Preliminary Modeling of Accident Tolerant Fuel Concepts under Accident Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gamble, Kyle A.; Hales, Jason D.

    2016-12-01

    The catastrophic events that occurred at the Fukushima-Daiichi nuclear power plant in 2011 have led to widespread interest in research of alternative fuels and claddings that are proposed to be accident tolerant. Thus, the United States Department of Energy through its NEAMS (Nuclear Energy Advanced Modeling and Simulation) program has funded an Accident Tolerant Fuel (ATF) High Impact Problem (HIP). The ATF HIP is funded for a three-year period. The purpose of the HIP is to perform research into two potential accident tolerant concepts and provide an in-depth report to the Advanced Fuels Campaign (AFC) describing the behavior of the concepts, both of which are being considered for inclusion in a lead test assembly scheduled for placement into a commercial reactor in 2022. The initial focus of the HIP is on uranium silicide fuel and iron-chromium-aluminum (FeCrAl) alloy cladding. Utilizing the expertise of three national laboratory participants (INL, LANL, and ANL) a comprehensive mulitscale approach to modeling is being used including atomistic modeling, molecular dynamics, rate theory, phase-field, and fuel performance simulations. In this paper, we present simulations of two proposed accident tolerant fuel systems: U3Si2 fuel with Zircaloy-4 cladding, and UO2 fuel with FeCrAl cladding. The simulations investigate the fuel performance response of the proposed ATF systems under Loss of Coolant and Station Blackout conditions using the BISON code. Sensitivity analyses are completed using Sandia National Laboratories’ DAKOTA software to determine which input parameters (e.g., fuel specific heat) have the greatest influence on the output metrics of interest (e.g., fuel centerline temperature). Early results indicate that each concept has significant advantages as well as areas of concern. Further work is required prior to formulating the proposition report for the Advanced Fuels Campaign.

  20. Radioiodine treatment of recurrent hyperthyroidism in patients previously treated for Graves' disease by subtotal thyroidectomy

    DEFF Research Database (Denmark)

    Vestergaard, H; Laurberg, P

    1992-01-01

    Radioiodine therapy is often employed for treatment of patients with relapse of hyperthyroidism due to Graves' disease, after previous thyroid surgery. Little is known about the outcome of this treatment compared to patients with no previous surgery. A total of 20 patients who had received surgical...... treatment for Graves' hyperthyroidism 1-46 years previously and with relapse of the hyperthyroidism, and 25 patients with hyperthyroidism due to Graves' disease and no previous thyroid surgery were treated with radioiodine, following the same protocol. Early after treatment the previously operated patients...

  1. Mechanisms in endocrinology. Role of emotional stress in the pathophysiology of Graves' disease.

    Science.gov (United States)

    Falgarone, Géraldine; Heshmati, Hassan M; Cohen, Régis; Reach, Gérard

    2013-01-01

    The role of stress in the pathophysiology of Graves' disease is suggested by several clinical observations, by recent advances in immunology and by better understanding of autoimmune diseases which provides new insights into potential effects of stress hormones on T helper cell imbalance involved in the pathogenesis of autoimmune diseases. Stress management should therefore be an important part of the treatment of Graves' disease, as stress reduction may improve the effect of therapy. However, this field still requires interventional data to support stress management in the treatment of Graves' disease.

  2. Exploratory analysis of Spanish energetic mining accidents.

    Science.gov (United States)

    Sanmiquel, Lluís; Freijo, Modesto; Rossell, Josep M

    2012-01-01

    Using data on work accidents and annual mining statistics, the paper studies work-related accidents in the Spanish energetic mining sector in 1999-2008. The following 3 parameters are considered: age, experience and size of the mine (in number of workers) where the accident took place. The main objective of this paper is to show the relationship between different accident indicators: risk index (as an expression of the incidence), average duration index for the age and size of the mine variables (as a measure of the seriousness of an accident), and the gravity index for the various sizes of mines (which measures the seriousness of an accident, too). The conclusions of this study could be useful to develop suitable prevention policies that would contribute towards a decrease in work-related accidents in the Spanish energetic mining industry.

  3. The dominance of accidents caused by banalities

    DEFF Research Database (Denmark)

    Jørgensen, Kirsten

    . Nevertheless, the fact is that the simpler accidents normally caused by what might be regarded as banalities occur at a much higher frequencies and with many more fatalities and invalidities than any of what are usually regarded as the most dangerous kinds of accidents. In depth analysis of national statistics...... on accidents could reveal the kind of accidents we are talking about, where they happen, to whom, how, and what can be done about them. This would require a special registration system of the events leading up to the accident. The main results for the four most frequent types of accident will be described...... as an example of how much information such systems can offer in general for the work of accident prevention in more traditional and common enterprises....

  4. Evaluation de la fonction hépatique au cours du paludisme grave chez les enfants de moins de cinq ans à Kinshasa en République Démocratique du Congo

    Science.gov (United States)

    Kabamba, Arsène Tshikongo; Mukuku, Olivier; Shamashanga, Laurent Kwete; Kamunga, Daniel Badibanga; Bokanya, Alex Impele; Lukumwena, Zet Kalala; Longanga, Albert Otshudi

    2014-01-01

    Introduction Le paludisme est toujours compté parmi les problèmes de santé publique prioritaires en République Démocratique du Congo suite au nombre de malades et de décès qu'il provoque. Cette étude évalue l'atteinte de la fonction hépatique au cours du paludisme grave chez les enfants de moins de 5 ans. Méthodes Il s'agit d'une étude cas-témoins menée de janvier à juin 2013 à Kinshasa (République Démocratique du Congo) où le dosage des bilirubines totale, directe et indirecte et la mesure de l'activité enzymatique de la Glutamate Pyruvate Transaminase (GPT), de la Glutamate Oxaloacétate Transaminase (GOT) et du taux d'hémoglobine ont été faits chez 46 enfants âgés de moins de 5 ans atteints de paludisme grave (groupe I) et chez 46 autres considérés sains avec une goutte négative (groupe II). Les résultats obtenus ont été comparés dans les deux groupes et le seuil de signification a été fixé à p bilirubine directe, la bilirubine indirecte et la bilirubine totale chez les enfants atteints du paludisme grave. Ces analyses montrent une différence significative en défaveur de ces derniers (p < 0,001). Conclusion En effet, cette augmentation des taux plasmatiques des paramètres biologiques analysés observée chez les enfants gravement impaludés traduit ainsi une altération de la fonction hépatique au cours d'un paludisme grave chez l'enfant de moins de cinq ans. PMID:25870721

  5. Singkatan Dan Akronim Dalam Chatting Di Internet

    OpenAIRE

    Hervina M. S.

    2010-01-01

    Penelitian ini menganalis pola singkatan dan akronim dalam chatting di internet. Tujuan penelitian ini adalah mendeskripsikan pola singkatan dan akronim dalam chatting di internet dan mendeskripsikan pola singkatan dan akronim yang paling dominan digunakan dalam chatting di internet. Teori yang digunakan adalah singkatan, akronim, bahasa dalam chatting, sosiolinguistik. Pengumpulan data digunakan dengan metode simak, yaitu penyimakan terhadap penggunaan bahasa (Sudaryanto,1993:133), dan tekni...

  6. LINTASAN SEJARAH FILSAFAT PENDIDIKAN PERENIALISME DAN AKTUALISASINYA

    OpenAIRE

    2015-01-01

    Antara filsafat dan pendidikan terdapat kaitan yang erat. Filsafat memiliki aspek-aspek utama yang dapat dijadikan landasan bagi pendidikan. Aspek-aspek yang dimaksud adalah aspek-aspek metafisis, epistemologis, dan aksiologis. Aspek metafisis antara lain berkaitan dengan persoalan realitas yang tercermin pada bahan ajar, pengalaman dan keterampilan. Aspek epistemologis berkaitan dengan persoalan pengetahuan dan kebenaran, termasuk di dalamnya sumber belajar dan metode pembelajaran. Aspek aks...

  7. PEMBUATAN DAN KARAKTERISASI ARANG DARI BATANG TANAMAN GUMITIR (Tagetes erecta) PADA BERBAGAI SUHU DAN WAKTU PIROLISIS

    National Research Council Canada - National Science Library

    I Made Siaka; Ni Putu Diana Febriyanti; Emmy Sahara; I Made Sutha Negara

    2017-01-01

    ...) pada berbagai suhu dan waktu pirolisis. Penelitian ini dilakukan untuk memperoleh suhu dan waktu yang optimum dalam pembuatan arang serta mengetahui karakteristik arang yang dihasilkan pada suhu dan waktu optimumnya...

  8. Practical approaches in accident analysis

    Science.gov (United States)

    Stock, M.

    An accident analysis technique based on successive application of structural response, explosion dynamics, gas cloud formation, and plant operation failure mode models is proposed. The method takes into account the nonideal explosion characteristic of a deflagration in the unconfined cloud. The resulting pressure wave differs significantly from a shock wave and the response of structures like lamp posts and walls can differ correspondingly. This gives a more realistic insight into explosion courses than a simple TNT-equivalent approach.

  9. RESISTENSI AGAMA DAN BUDAYA MASYARAKAT

    Directory of Open Access Journals (Sweden)

    David Samiyono

    2013-12-01

    Interaksi antar etnis, agama dan budaya bukanlah barang langka di Bali. Sejak semula hal tersebut sudah ada, ketika pulau ini menjadi locus perdagangan hasil bumi. Sebab sesungguhnya kebudayaan Bali menjujung tinggi nilai-nilai keseimbangan dan harmonisasi antar manusia dengan Tuhan (perhyangan, dengan sesama (pawongan dan dengan lingkungan (palemahan. Konsep ini disebut Tri hita karana. Bali kini berubah. Budayanya berorientasi pada jasa, yang berkait dengan industri pariwisata. Sikap orang Bali kini tidak lagi ramah dan harmoni. Akibat ledakan bom dalam bulan Oktober 2002 dan 2005, masyarakat lebih berhati-hati terhadap para pendatang. Ajeg Bali merupakan kearifan lokal –agama dan budaya– masyarakat Bali dalam rangka menanggulangi pengaruh luar yang mengakibatkan perubahan di berbagai bidang sehingga identitas kebalian mengalami degradasi. Ajeg Bali merupakan bentuk resistensi masyar­akat Bali dalam rangka membatasi pendatang dari luar Bali. Kajian ini berusaha untuk menjawab pertanyaan “apakah Ajeg Bali, sebuah kearifan lokal masyarakat Bali dapat membendung pengaruh budaya, agama dan ekonomi masyarakat Bali?”

  10. Strategies of radioiodine therapy for Graves' disease

    Energy Technology Data Exchange (ETDEWEB)

    Lind, P. [Department of Nuclear Medicine and Endocrinology, PET Center Klagenfurt, LKH Klagenfurt (Austria)

    2002-08-01

    Several therapeutic options are available for the treatment of Graves' disease (GD), including long-term antithyroid drug medication (ATD), near-total resection (NTR) and radioiodine therapy (RIT). These treatments are used with different frequencies depending on geographical location, size of the goitre, age of the patient and experience of the physician. It should be noted that RIT is still being applied more frequently in the United States than in Europe. Despite the fact that RIT was introduced as long ago as 1941, several questions are still the subject of debate: Should a fixed dose or a calculated dose be used. If the dose is calculated, how many Grays (Gy) should be delivered to the thyroid? What is the goal of RIT in GD? Which factors, including ATD, influence the outcome of RIT? Is RIT appropriate in GD with Graves' ophthalmopathy (GO)? Although not all these questions have been answered yet, conclusions can be derived regarding a general strategy for use of RIT in GD. As with surgery, the goal of RIT in GD is euthyroidism with or without L-thyroxine medication. There is a clear advantage of dose calculation over use of a fixed dose because the only factor influencing the outcome is the dose delivered to a certain thyroid volume. To minimise recurrent hyperthyroidism, an ablative approach using a delivered dose of 250 Gy is widely accepted. Beside pretherapeutic T{sub 3} levels, thyroid volume and 24-h thyroid uptake, ATD may influence the outcome of RIT. Today it is accepted by most thyroidologists that, if ATD medication is necessary in overt hyperthyroidism, it should be withdrawn at least 2 days before RIT. In patients with GD and GO, RIT may worsen GO. If RIT is performed in GO it should be done under a 3-month steroid medication regimen. In conclusion, RIT can be considered an appropriate and cost-effective therapy in GD, although the decision regarding treatment should be taken on an individual basis, paying due respect to the course and

  11. Agranulocitosis inducida por metimazol en pacientes con enfermedad de Graves

    Directory of Open Access Journals (Sweden)

    Helard Manrique-Hurtado

    2013-04-01

    Full Text Available Objetivo: Describir las características clínicas y epidemiológicas de los pacientes con enfermedad de Graves que presentaron agranulocitosis inducida por metimazol. Material y métodos: Estudio retrospectivo, tipo serie de casos. Se revisaron las historias clínicas de todos los pacientes con diagnóstico de agranulocitosis inducida por metimazol, atendidos en el Hospital Nacional Arzobispo Loayza, entre enero 2002 y diciembre 2008. Se buscó asociación entre las variables demográficas y clínicas con la mortalidad y el tiempo de recuperación. Resultados: Treinta (0,60% pacientes con enfermedad de Graves fueron hospitalizados con el diagnóstico de agranulocitosis inducida por metimazol. La mediana de la edad fue 33,5 años y 86,67% fueron mujeres. Al ingreso, todos los pacientes presentaron fiebre y dolor de garganta. El manejo incluyó aislamiento invertido, suspensión del metimazol, administración de antibióticos y glucocorticoides. Doce (40% pacientes recibieron GM-CSF. El número de granulocitos se normalizó después de 10,59 días y cuatro (13,33% pacientes murieron por infecciones bacterianas y sepsis. En todos los casos, el tratamiento definitivo fue yodo radioactivo. No hubo diferencia significativa en la edad, sexo, dosis de metimazol, duración del tratamiento y uso de factor estimulante colonia, entre los pacientes fallecidos y los sobrevivientes. Además, el uso de factor estimulante de colonia no redujo el tiempo de recuperación de la agranulocitosis. Conclusión: La agranulocitosis inducida por metimazol es un evento adverso serio y potencialmente mortal. En este grupo de pacientes, la mortalidad fue elevada y el uso de factor estimulante de colonia no disminuyó el tiempo de recuperación.

  12. The consequences of Chernobyl accident

    Directory of Open Access Journals (Sweden)

    Ion Chioșilă

    2016-12-01

    Full Text Available These days marks 30 years since the Chernobyl nuclear accident, followed by massive radioactive contamination of the environment and human in Belarus, Ukraine and Russia, and resulted in many deaths among people who intervened to decrease the effects of the nuclear disaster. The 26 April 1986 nuclear accident contaminated all European countries, but at a much lower level, without highlighted consequences on human health. In special laboratories, the main radionuclides (I-131, Cs-137, Cs-134 and Sr-90 were also analyzed in Romania from environmental samples, food, even human subjects. These radionuclides caused the population to receive a low dose of about 1 mSv in 1986 that is half of the dose of the natural background radiation (2.4 mSv per year. As in all European countries (excluding Ukraine, Belarus and Russia this dose of about 1 mSv fell rapidly by 1990, reaching levels close to ones before the accident at the nuclear tests.

  13. [Multicenter paragliding accident study 1990].

    Science.gov (United States)

    Lautenschlager, S; Karli, U; Matter, P

    1992-01-01

    During the period from 1.1.90 until 31.12.90, 86 injuries associated with paragliding were analyzed in a prospective study in 12 different Swiss hospitals with reference to causes, patterns, and frequencies. The injuries showed a mean score of over 2 and were classified as severe. Most frequent spine injuries (36%) and lesions of the lower extremity (35%) with a high risk of the ankles were diagnosed. One accident was fatal. 60% of the accidents happened during landing, 26% during launching and 14% during flight. Half of the pilots were affected during their primary training course. Most accidents were caused by inflight error of judgement--especially incorrect estimation of wind conditions--and further the choice of unfavourable landing sites. In contrast to previous injury-reports, only one equipment failure could be noted, but often the equipment was not corresponding with the experience and the weight of the pilot. To reduce the frequency of paragliding-injuries an accurate choice of equipment and an increased attention to environmental factors is mandatory. Furthermore an education-program regarding the attitude and intelligence of the pilot should be included in training courses.

  14. Medical consequences of Chernobyl accident

    Directory of Open Access Journals (Sweden)

    Galstyan I.A.

    2015-12-01

    Full Text Available Aim: to study the long-term effects of acute radiation syndrome (ARS, developed at the victims of the Chernobyl accident. Material and Methods. 237 people were exposed during the accident, 134 of them were diagnosed with ARS. Dynamic observation implies a thorough annual examination in a hospital. Results. In the first 1.5-2 years after the ARS mean group indices of peripheral blood have returned to normal. However, many patients had transient expressed moderate cytopenias. Granulocytopenia, thrombocytopenia, lymphopenia and erythropenia were the most frequently observed things during the first 5 years after the accident. After 5 years their occurences lowered. In 11 patients the radiation cataract was detected. A threshold dose for its development is a dose of 3.2 Gy Long-term effects of local radiation lesions (LRL range from mild skin figure smoothing to a distinct fibrous scarring, contractures, persistently recurrent late radiation ulcers. During all years of observation we found 8 solid tumors, including 2 thyroid cancers. 5 hematologic diseases were found. During 29 years 26 ARS survivors died of various causes. Conclusion. The health of ones with long-term ARS effects is determined by the evolution of the LRL effects on skin, radiation cataracts, hema-tological diseases and the accession of of various somatic diseases, not caused by radiation.

  15. Development of Graves' ophthalmopathy and uveitis after radioiodine therapy for Graves' disease in a patient with HTLA-I associated myelopathy (HAM)

    Energy Technology Data Exchange (ETDEWEB)

    Ozawa, Yasunori; Migita, Masayoshi; Watanabe, Tomoji; Okuda, Itsuko; Takeshita, Akira; Takagi, Akio; Shishiba, Yoshimasa (Toranomon Hospital, Tokyo (Japan))

    1994-09-01

    HTLV-I carriers or patients with HTLV-I associated myelopathy (HAM) are prone to immune-mediated inflammatory disorders. We present a 44-year-old female with HAM who developed Graves' disease. She developed severe Graves' ophthalmopathy shortly after [sup 131]I therapy, concurrently with a remarkable increase in TSH-receptor antibody titer. Ophthalmopathy was aggravated in spite of prednisolone therapy and euthyroidism being maintained by thyroxine replacement. Uveitis also developed after [sup 131]I therapy and iridocyclitis finally required trabeculotomy. This case suggests that HAM patients may have a higher risk of immune-mediated Graves' ophthalmopathy after [sup 131]I therapy.(author).

  16. Kitab kuning dan perempuan, perempuan dan kitab kuning

    NARCIS (Netherlands)

    Bruinessen, M.M. van

    2007-01-01

    Kitab Kuning dan Emansipasi Perempuan: Konflik Budaya? Pengamatan-pengamatan Masdar mengenai kedudukan perempuan dalam diskursus (wacana, bahasan) dominan kitab kuning terasa tidak enak didengar tetapi memang sulit dibantah. Baik dalam penggunaan bahasa (yang sangat memihak kepada jenis mudzakkar) m

  17. Transconjunctival orbital decompression in Graves' ophthalmopathy: lateral wall approach ab interno

    NARCIS (Netherlands)

    D.A. Paridaens; K. Verhoeff; D. Bouwens; W.A. van den Bosch (Willem)

    2000-01-01

    textabstractAIMS: A modified surgical technique is described to perform a one, two, or three wall orbital decompression in patients with Graves' ophthalmopathy. METHODS: The lateral wall was approached ab interno through a "swinging eyelid" approach (lateral canthotomy

  18. Outcome of orbital decompression for disfiguring proptosis in patients with Graves' orbitopathy using various surgical procedures

    NARCIS (Netherlands)

    Mourits, M. P.; Bijl, H.; Altea, M. A.; Baldeschi, L.; Boboridis, K.; Curro, N.; Dickinson, A. J.; Eckstein, A.; Freidel, M.; Guastella, C.; Kahaly, G. J.; Kalmann, R.; Krassas, G. E.; Lane, C. M.; Lareida, J.; Marcocci, C.; Marino, M.; Nardi, M.; Mohr, Ch; Neoh, C.; Pinchera, A.; Orgiazzi, J.; Pitz, S.; Saeed, P.; Salvi, M.; Sellari-Franceschini, S.; Stahl, M.; von Arx, G.; Wiersinga, W. M.

    2009-01-01

    Aim: To compare the outcome of various surgical approaches of orbital decompression in patients with Graves' orbitopathy (GO) receiving surgery for disfiguring proptosis. Method: Data forms and questionnaires from consecutive, euthyroid patients with inactive GO who had undergone orbital decompressi

  19. Disease Activity in Graves' Ophthalmopathy: Diagnosis with Orbital MR Imaging and Correlation with Clinical Score

    National Research Council Canada - National Science Library

    Tortora, Fabio; Cirillo, Mario; Ferrara, Marco; Belfiore, Maria Paola; Carella, Carlo; Caranci, Ferdinando; Cirillo, Sossio

    2013-01-01

    In Graves' ophthalmopathy (GO) it is important to distinguish acute inflammation at an early stage, responsive to immunosuppressive treatment, from inactive fibrotic end stage disease, unresponsive to the same treatment...

  20. Mechanisms in endocrinology. Role of emotional stress in the pathophysiology of Graves' disease

    National Research Council Canada - National Science Library

    Falgarone, Géraldine; Heshmati, Hassan M; Cohen, Régis; Reach, Gérard

    2013-01-01

    The role of stress in the pathophysiology of Graves' disease is suggested by several clinical observations, by recent advances in immunology and by better understanding of autoimmune diseases which...

  1. Affective symptoms and cognitive functions in the acute phase of Graves' thyrotoxicosis

    DEFF Research Database (Denmark)

    Vogel, Asmus; Elberling, Tina V; Hørding, Merete

    2007-01-01

    In the acute phase of Graves' thyrotoxicosis patients often have subjective cognitive complaints. Continuing controversy exists about the nature of these symptoms and whether they persist after treatment. This prospective study included 31 consecutively referred, newly diagnosed, and untreated pa...

  2. Perancangan dan Analisis Redistribution Routing Protocol OSPF dan EIGRP

    Directory of Open Access Journals (Sweden)

    DWI ARYANTA

    2016-02-01

    Full Text Available Abstrak OSPF (Open Shortest Path First dan EIGRP (Enhanced Interior Gateway Routing Protocol adalah dua routing protokol yang banyak digunakan dalam jaringan komputer. Perbedaan karakteristik antar routing protokol menimbulkan masalah dalam pengiriman paket data. Teknik redistribution adalah solusi untuk melakukan komunikasi antar routing protokol. Dengan menggunakan software Cisco Packet Tracer 5.3 pada penelitian ini dibuat simulasi OSPF dan EIGRP yang dihubungkan oleh teknik redistribution, kemudian dibandingkan kualitasnya dengan single routing protokol EIGRP dan OSPF. Parameter pengujian dalam penelitian ini adalah nilai time delay dan trace route. Nilai trace route berdasarkan perhitungan langsung cost dan metric dibandingkan dengan hasil simulasi. Hasilnya dapat dilakukan proses redistribution OSPF dan EIGRP. Nilai delay redistribution lebih baik 1% dibanding OSPF dan 2-3% di bawah EIGRP tergantung kepadatan traffic. Dalam perhitungan trace route redistribution dilakukan 2 perhitungan, yaitu cost untuk area OSPF dan metric pada area EIGRP. Pengambilan jalur utama dan alternatif pengiriman paket berdasarkan nilai cost dan metric yang terkecil, hal ini terbukti berdasarkan perhitungan dan simulasi. Kata kunci: OSPF, EIGRP, Redistribution, Delay, Cost, Metric. Abstract OSPF (Open Shortest Path First and EIGRP (Enhanced Interior Gateway Routing Protocol are two routing protocols are widely used in computer networks. Differences between the characteristics of routing protocols pose a problem in the delivery of data packets. Redistribution technique is the solution for communication between routing protocols. By using the software Cisco Packet Tracer 5.3 in this study were made simulating OSPF and EIGRP redistribution linked by technique, then compared its quality with a single EIGRP and OSPF routing protocols. Testing parameters in this study is the value of the time delay and trace route. Value trace route based on direct calculation of cost

  3. Temporal Statistic of Traffic Accidents in Turkey

    Science.gov (United States)

    Erdogan, S.; Yalcin, M.; Yilmaz, M.; Korkmaz Takim, A.

    2015-10-01

    Traffic accidents form clusters in terms of geographic space and over time which themselves exhibit distinct spatial and temporal patterns. There is an imperative need to understand how, where and when traffic accidents occur in order to develop appropriate accident reduction strategies. An improved understanding of the location, time and reasons for traffic accidents makes a significant contribution to preventing them. Traffic accident occurrences have been extensively studied from different spatial and temporal points of view using a variety of methodological approaches. In literature, less research has been dedicated to the temporal patterns of traffic accidents. In this paper, the numbers of traffic accidents are normalized according to the traffic volume and the distribution and fluctuation of these accidents is examined in terms of Islamic time intervals. The daily activities and worship of Muslims are arranged according to these time intervals that are spaced fairly throughout the day according to the position of the sun. The Islamic time intervals are never been used before to identify the critical hour for traffic accidents in the world. The results show that the sunrise is the critical time that acts as a threshold in the rate of traffic accidents throughout Turkey in Islamic time intervals.

  4. [Accidents in travellers - the hidden epidemic].

    Science.gov (United States)

    Walz, Alexander; Hatz, Christoph

    2013-06-01

    The risk of malaria and other communicable diseases is well addressed in pre-travel advice. Accidents are usually less discussed. Thus, we aimed at assessing accident figures for the Swiss population, based on data of the register from 2004 to 2008 of the largest Swiss accident insurance organization (SUVA). More than 139'000 accidents over 5 years showed that 65 % of the accidents overseas are injuries, and 24 % are caused by poisoning or harm by cold, heat or air pressure. Most accidents happened during leisure activities or sports. More than one third of the non-lethal and more than 50 % of the fatal accidents happened in Asia. More than three-quarters of non-lethal accidents take place in people between 25 and 54 years. One out of 74 insured persons has an accident abroad per year. Despite of many analysis short-comings of the data set with regard to overseas travel, the figures document the underestimated burden of disease caused by accidents abroad and should affect the given pre-health advice.

  5. TEMPORAL STATISTIC OF TRAFFIC ACCIDENTS IN TURKEY

    Directory of Open Access Journals (Sweden)

    S. Erdogan

    2015-10-01

    Full Text Available Traffic accidents form clusters in terms of geographic space and over time which themselves exhibit distinct spatial and temporal patterns. There is an imperative need to understand how, where and when traffic accidents occur in order to develop appropriate accident reduction strategies. An improved understanding of the location, time and reasons for traffic accidents makes a significant contribution to preventing them. Traffic accident occurrences have been extensively studied from different spatial and temporal points of view using a variety of methodological approaches. In literature, less research has been dedicated to the temporal patterns of traffic accidents. In this paper, the numbers of traffic accidents are normalized according to the traffic volume and the distribution and fluctuation of these accidents is examined in terms of Islamic time intervals. The daily activities and worship of Muslims are arranged according to these time intervals that are spaced fairly throughout the day according to the position of the sun. The Islamic time intervals are never been used before to identify the critical hour for traffic accidents in the world. The results show that the sunrise is the critical time that acts as a threshold in the rate of traffic accidents throughout Turkey in Islamic time intervals.

  6. Perawatan Pergeseran Mandibula dan Kliking Menggunakan Teknik Edgewise dan Trainer

    Directory of Open Access Journals (Sweden)

    Rully Utami

    2014-06-01

    Full Text Available Kasus ini terjadi pada perempuan usia 22 tahun yang bersedia dipublikasikan untuk kepentingan  ilmu pengetahuan. Keluhan utama mandibula dan dagunya bergeser ke kanan, gigitan terbuka posterior dan bunyi click di persendian temporomandibular. Diagnosis pasien adalah maloklusi Angle kelas III tipe dento skeletal, pergeseran garis tengah mandibula dan dagu ke kanan, gigitan terbuka posterior dan clicking pada sendi temporomandibular. Perawatan dilakukan dengan teknik Edgewise dan trainer. Leveling dan unraveling dilakukan menggunakan kawat stainless steel bulat diameter 0,014 mm dengan multiloop. Trainer digunakan untuk koreksi pergeseran mandibula. Perawatan dilakukan selama 11 bulan, dan menunjukkan hasil hubungan molar pertama kanan menjadi kelas I. Overjet meningkat dari 0,1 mm menjadi 2 mm, overbite meningkat dari 0,2 mm menjadi 2,57 mm, garis tengah mandibula yang semula bergeser ke kanan 4,38 mm menjadi 2,53 mm, gigitan terbuka posterior dan clicking telah terkoreksi. Compromised Treatment of Class III Malocclusion with Mandibular Shifting, Posterior Openbite and Clicking Using Edgewise Technique and Trainer In Adult. This case report described the treatment of an adult female 22 years old who complained that her mandibula and chin shift to the right, posterior openbite and clicking. The patient diagnosed class III molar relationship, skeletal class III malocclusion, mandibular midline and chin shift to the right, posterior openbite and clicking on temporomandibular joint. Treatment was conducted using combination between  Edgewise Technique and trainer.  Leveling and unraveling are achieved by round stainless steel archwire 0,014 mm with multiloop. Trainer used to corrected the mandibular shifting. Result after 1 years treatment showed that the right molar relationship became class I, overjet increased  from 0,1 mm to 2 mm, overbite increased  from 0,2 mm to 2,57 mm, mandibular midline shifting decresed from 4,38 mm to 2,53 mm

  7. Severe Accident Recriticality Analyses (SARA)

    Energy Technology Data Exchange (ETDEWEB)

    Frid, W. [Swedish Nuclear Power Inspectorate, Stockholm (Sweden); Hoejerup, F. [Risoe National Lab. (Denmark); Lindholm, I.; Miettinen, J.; Puska, E.K. [VTT Energy, Helsinki (Finland); Nilsson, Lars [Studsvik Eco and Safety AB, Nykoeping (Sweden); Sjoevall, H. [Teoliisuuden Voima Oy (Finland)

    1999-11-01

    Recriticality in a BWR has been studied for a total loss of electric power accident scenario. In a BWR, the B{sub 4}C control rods would melt and relocate from the core before the fuel during core uncovery and heat-up. If electric power returns during this time-window unborated water from ECCS systems will start to reflood the partly control rod free core. Recriticality might take place for which the only mitigating mechanisms are the Doppler effect and void formation. In order to assess the impact of recriticality on reactor safety, including accident management measures, the following issues have been investigated in the SARA project: 1. the energy deposition in the fuel during super-prompt power burst, 2. the quasi steady-state reactor power following the initial power burst and 3. containment response to elevated quasi steady-state reactor power. The approach was to use three computer codes and to further develop and adapt them for the task. The codes were SIMULATE-3K, APROS and RECRIT. Recriticality analyses were carried out for a number of selected reflooding transients for the Oskarshamn 3 plant in Sweden with SIMULATE-3K and for the Olkiluoto 1 plant in Finland with all three codes. The core state initial and boundary conditions prior to recriticality have been studied with the severe accident codes SCDAP/RELAP5, MELCOR and MAAP4. The results of the analyses show that all three codes predict recriticality - both superprompt power bursts and quasi steady-state power generation - for the studied range of parameters, i. e. with core uncovery and heat-up to maximum core temperatures around 1800 K and water flow rates of 45 kg/s to 2000 kg/s injected into the downcomer. Since the recriticality takes place in a small fraction of the core the power densities are high which results in large energy deposition in the fuel during power burst in some accident scenarios. The highest value, 418 cal/g, was obtained with SIMULATE-3K for an Oskarshamn 3 case with reflooding

  8. Cradle-to-Grave Logistic Technologies for Exploration Missions

    Science.gov (United States)

    Broyan, James L.; Ewert, Michael K.; Shull, Sarah

    2013-01-01

    Human exploration missions under study are very limited by the launch mass capacity of exiting and planned vehicles. The logistical mass of crew items is typically considered separate from the vehicle structure, habitat outfitting, and life support systems. Consequently, crew item logistical mass is typically competing with vehicle systems for mass allocation. NASA is Advanced Exploration Systems (AES) Logistics Reduction and Repurposing (LRR) Project is developing four logistics technologies guided by a systems engineering cradle-to-grave approach to enable used crew items to augment vehicle systems. Specifically, AES LRR is investigating the direct reduction of clothing mass, the repurposing of logistical packaging, the processing of spent crew items to benefit radiation shielding and water recovery, and the conversion of trash to propulsion supply gases. The systematic implementation of these types of technologies will increase launch mass efficiency by enabling items to be used for secondary purposes and improve the habitability of the vehicle as the mission duration increases. This paper provides a description, benefits, and challenges of the four technologies under development and a status of progress at the mid ]point of the three year AES project.

  9. Special features of Graves' disease in early childhood.

    Science.gov (United States)

    Segni, M; Leonardi, E; Mazzoncini, B; Pucarelli, I; Pasquino, A M

    1999-09-01

    Graves' disease (GD) is extremely rare in children younger than 4 years of age, but if not recognized and treated it can seriously interfere with growth and development. We report three unrelated children, all females, in whom GD occurred before the age of 3. These children presented with goiter, exophthalmos, tachycardia, and hyperactivity. Moreover, one showed a severe psychomotor delay, and had previously undergone surgery due to craniosynostosis; the other two manifested a language delay. All had high thyroid hormones and thyrotropin receptor antibody (TRAb) serum levels that clearly indicated autoimmune hyperthyroidism. In all of them, the disease presumably had developed during the first or second year of life. No maternal history of GD was present in two. The third child was born to a mother affected with GD during pregnancy, but it is likely that her GD began to develop after 6 months of life. These children are being treated with methimazole, and treatment is still necessary after 32 months. TRAb levels were persistently high at follow-up. Psychological evaluation including language development at follow-up was appropriate for age in two children; the third child improved, but severe mental retardation is still evident. GD assessment in early childhood also needs to focus on psychological evaluation. Pediatricians should be aware of the possibility of permanent brain damage and craniosynostosis due to hyperthyroidism in infancy.

  10. [Graves' disease: ultrasonographic, color Doppler and histological aspects].

    Science.gov (United States)

    Messina, G; Viceconti, N; Trinti, B

    1997-11-01

    The aim of the present work was to study the relationship between thyroid low echogenicity, the thyroid blood flow by color-Doppler (CD) and histological features in patients with Graves' disease (GD). Thyroid ultrasonography and CD was performed on 28 patients with GD. In 5 patients has been compared CD with histology. The thyroid volume was higher in 100% of patients with GD at the onset rather than in euthyroidism. Diffuse hypoechogenicity of the thyroid was discovered in 100% of patients with GD at the onset and it persisted in 57.1% of patients that became euthyroid after therapy. Qualitative CD resulted in different patterns that were classified as follow: pattern A ("thyroid inferno") in 17 patients (60.7%); pattern B (mildly increased of parenchymal blood flow) in 11 patients (39.3%). In the 5 histological proven cases, in the pattern A (3 cases) there was a diffuse microfollicular hyperplasia with functional activation notes. There was lymphocytic infiltration. While in the pattern B (two cases) there were a non-follicular hypercellular nodule with pseudocapsule and rare colloid. We conclude that there are two different histological types with different CD patterns in GD.

  11. Sheehan's syndrome co-existing with Graves' disease.

    Science.gov (United States)

    Arpaci, D; Cuhaci, N; Saglam, F; Ersoy, R; Cakir, B

    2014-01-01

    Sheehan's syndrome (SS), which is an important cause of hypopituitarism, is common in developing countries. The most common presentation is the absence of lactation and amenorrhea. Hypothyroidism rather than hyperthyroidism is the usual expected phenomenon in SS. Postpartum hyperthyroidism is also common and Graves' disease (GD) is an important cause of postpartum hyperthyroidism. Here we report a case of a 22-year-old female patient in our clinic presented symptoms of amenorrhea, lack of lactation, palpitations and sweating. Her physical examination revealed goiter, moist skin and proptosis. Her laboratory evaluation showed suppressed thyroid stimulating hormone, elevated levels of free thyroxine and free triiodothyronine. Thyroid antibodies were positive. Tec 99m thyroid scintigraphy results were gland hyperplasia and increased uptake consistent with GD. She gave birth 7 months ago; after delivery she had a history of prolonged bleeding, amenorrhea and inability to lactate. She had hypogonadotropic hypogonadism, hyperprolactinemia and growth hormone deficiency. Serum cortisol and adrenocorticotropic hormone levels were normal. Her magnetic resonance imaging was empty sella. Our diagnosis was GD co-existing with SS. GD with concomitant hypopituitarism is rare but has been described previously, but there are no reports of GD occurring with SS. In this case study, we report a patient with GD associated with SS.

  12. KONSEP DAN PRAKTIK PENDIDIKAN MULTIKULTURAL DI AMERIKA SERIKAT DAN INDONESIA

    Directory of Open Access Journals (Sweden)

    Juju Masunah

    2011-11-01

    Full Text Available Abstract: Concepts and Practices of Multi Cultural Education in the United States and in Indonesia. The purpose of this article is to discuss multicultural education consepts and practices in the U.S.A and its application to Indonesia. Data is based on a case study research of two dance educators who implemented multicultural education concept in Columbus, Ohio in year 2007. The result of this research is that two dance educators teach students equally by developing a curriculum and pedagogy that face democracy for all students. This concept and practice is possible to be applied to dance education in Indonesia. Abstrak: Konsep dan Praktik Pendidikan Multikultural di Amerika Serikat dan Indonesia. Tujuan artikel ini adalah untuk mendiskusikan konsep dan praktik pendidikan multikultural di Amerika Serikat dan Indonesia. Data-data diperoleh dari hasil penelitian studi kasus dua orang pendidik tari di Columbus, Ohio yang menerapkan konsep pendidikan multikultural dalam pembelajaran tari pada tahun 2007. Peneli­tian ini menyimpulkan bahwa dua guru tari tersebut memberi perlakuan yang sama dan adil terhadap se­mua siswa dengan cara yang demokratis dengan memperhatikan keberagaman dan keperbedaan siswa. Cara-cara ini sangat memungkinkan untuk diaplikasikan dalam pendidikan tari di Indonesia.

  13. Prognostic factors of the outcomes of subtotal thyroid resection in graves disease

    Directory of Open Access Journals (Sweden)

    A J Tsurkan

    2011-03-01

    Full Text Available The long-term results of subtotal resection of thyroid gland on 82 patients with Graves' disease were studied. There was analysed the influence of three factors on outcome at Graves' disease: volume of a thyroid gland before operation, morphological structure of thyroid tissue and volume of thyroid remnant. Outcomes of subtotal resection of thyroid gland were studied on the basis of thyrotropic hormone level of blood in 3, 6, 12 months, 2 and 3 years after operation. Based on research it has been established that the volume of thyroid gland before operation does not influence to outcome of subtotal resection of thyroid gland with Graves' disease. Morphological changes of removed thyroid tissue in the form of colloidal nodules at patients with Graves' disease statistically significantly raise risk of development of postoperative complications after subtotal resection of thyroid gland. The surgeon defining the volume of thyroid rem-nant durng the operation could be mistaken as towards it's increase so towards it's reduction, with an average deviation about 35%. Various outcomes of subtotal resection of thyroid gland at the same volume of thyroid remnant let us conclude that this out-come depends more on intensity of autoimmune process rather than on the volume of thyroid remnant. According modern views to aetiology and patogenesis of Graves' disease, the optimum volume of operation at Graves' disease is thyroidectomy.

  14. Radioiodine therapy for Graves' disease: case selection and restrictions recommended to patients in North America.

    Science.gov (United States)

    Wartofsky, L

    1997-04-01

    Each of the three major therapies for Graves' disease has its own advantages, disadvantages, indications, and contraindications. Today, radioactive iodine (RAI) therapy is the most commonly employed means of therapy for Graves' disease in the United States, with approximately 70% of patients so treated after initial presentation and an additional fraction of arguably 10-15% treated with RAI after failure of antithyroid drugs or surgery. RAI therapy is acknowledged to have the clear-cut advantage of being safe, with low morbidity and cost. The indications for RAI therapy are clear and noncontroversial for most patients with Graves' disease. Moreover, RAI treatment is employed by some thyroidologists for subclinical thyrotoxicosis (normal T4 or T3 but immeasurable TSH), particularly in patients > age 45 due to risks of atrial fibrillation. RAI therapy is not considered indicated or is contraindicated during breast feeding and in pregnancy, subacute thyroiditis, postpartum thyroiditis, struma ovarii, pituitary (TSH-driven) hyperthyroidism, euthyroid, hyperthyroxinemia, and thyroid hormone resistance. Opinions vary on the use of RAI therapy in children with Graves' disease; generally, a lower age cutoff of 17 years is acceptable in most clinics. Even more controversial is whether RAI therapy in the presence of Graves' ophthalmology constitutes a risk for worsening ophthalmopathy. Resolution of this latter issue awaits more definitive studies, but RAI therapy is likely to remain the first choice for most patients with Graves' disease.

  15. Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy

    Directory of Open Access Journals (Sweden)

    Yeoree Yang

    2015-12-01

    Full Text Available The three major forms of treatment for Graves thyrotoxicosis are antithyroid drugs, radioactive iodine therapy and thyroidectomy. Surgery is the definitive treatment for Graves thyrotoxicosis that is generally recommended when other treatments have failed or are contraindicated. Generally, thyrotoxic patients should be euthyroid before surgery to minimize potential complications which usually requires preoperative management with thionamides or inorganic iodine. But several cases of refractory Graves' disease have shown resistance to conventional treatment. Here we report a 40-year-old female patient with Graves' disease who complained of thyrotoxic symptoms for 7 months. Her thyroid function test and thyroid autoantibody profiles were consistent with Graves' disease. One kind of thionamides and β-blocker were started to control her disease. However, she was resistant to nearly all conventional medical therapies, including β-blockers, inorganic iodine, and two thionamides. She experienced hepatotoxicity from the thionamides. What was worse is her past history of serious allergic reaction to corticosteroids, which are often used to help control symptoms. A 2-week regimen of high-dose cholestyramine improved her uncontrolled thyrotoxicosis and subsequent thyroidectomy was successfully performed. In conclusion, cholestyramine could be administered as an effective and safe adjunctive agent for preoperative preparation in patients with severe hyperthyroid Graves's disease that is resistant to conventional therapies.

  16. RADIKALISME NEGARA DAN KEKUASAAN PERSPEKTIF POLITIK GLOBAL

    Directory of Open Access Journals (Sweden)

    M. Sidi Ritaudin

    2014-12-01

    Full Text Available Meskipun tragedi kemanusiaan yang berbasis terorisme bersifat domistik regional, tetapi sebab musababnya, setelah dilakukan penelusuran secara kritis dan tajam serta mendalam oleh para ahli, adalah dimensi politik global. Ini bukan asumsi tetapi fakta dan realita. Sebut saja misalnya tragedi WTC di Amerika serikat 11 September 2001, yang berbuntut pada pembumihangusan Irak, pembantaian dan pembunuhan secara keji di Palestina. Dan saat ini terjadi pembumihangusan Irak jilid dua dengan peristiwa ISIS, tragedi kemanusiaan di Ukraina dan Somalia. Sebahagian pemerhati Islam dan Timur Tengah menengarai bahwa motif gerakan radikalisme merupakan antitesa dari keserakahan politik, ekonomi, kekuasaan dan keangkuhan peradaban. Paradoksal radikalisme Islam dengan para aktivis pengusung ide sekularisme, pluralisme, dan liberalisme agama sudah berlangsung cukup lama dan tiada berkesudahan, menarik untuk didiskusikan.

  17. CORPORATE IDENTITY SEJARAH DAN APLIKASINYA

    Directory of Open Access Journals (Sweden)

    Christine Suharto Cenadi

    1999-01-01

    Full Text Available In the recent globalization era%2C and the developed market%2C many companies compete to attract consumers to buy their products. One of the keys to compete and survive in this developing market is by creating an image and graphic identity. This paper will discuss about corporate identity%2C image%2C its purpose and applications. Abstract in Bahasa Indonesia : Dalam era globalisasi dewasa ini%2C dan dengan berkembangnya pasar (market%2C banyak perusahaan bersaing untuk menarik perhatian konsumen untuk membeli produknya. Salah satu cara untuk bersaing dan dapat bertahan di dalam pasar yang terus berkembang ini adalah dengan menciptakan suatu image dan identitas graphic. Tulisan ini akan membahas tentang corporate identity%2C image%2C fungsi dan aplikasinya

  18. Quantifying the risk of extreme aviation accidents

    Science.gov (United States)

    Das, Kumer Pial; Dey, Asim Kumer

    2016-12-01

    Air travel is considered a safe means of transportation. But when aviation accidents do occur they often result in fatalities. Fortunately, the most extreme accidents occur rarely. However, 2014 was the deadliest year in the past decade causing 111 plane crashes, and among them worst four crashes cause 298, 239, 162 and 116 deaths. In this study, we want to assess the risk of the catastrophic aviation accidents by studying historical aviation accidents. Applying a generalized Pareto model we predict the maximum fatalities from an aviation accident in future. The fitted model is compared with some of its competitive models. The uncertainty in the inferences are quantified using simulated aviation accident series, generated by bootstrap resampling and Monte Carlo simulations.

  19. Comparative Analysis of the Pattern of Severe Injury Due to Road Traffic Accidents in Children

    Directory of Open Access Journals (Sweden)

    Ye. A. Spiridonova

    2010-01-01

    Full Text Available Objective: to study stepwise differences in the severity and pattern of severe traumatic injuries due to road traffic accidents in patients during the qualified and specialized stages of medical care in the age groups of 1 month to 18 years in the Rostov Region. Material and methods. The 2004—2009 case reports were used to make a retrospective comparative assessment of the condition of victims with severe road traffic injury at care stages in 2 groups: 1 one-month- to 18-year-old children who had been primarily admitted to the qualified-stage intensive care units (n=61; 2 one-month-to 18-year-old patients from the intensive care unit of the Regional Children’s Hospital, referred from the qualified-stage intensive care units (n=133. Results. The number of specialized-stage children in grave and extremely extensive grave condition at the specialized stage was 14.7% more than that at the qualified stage (100 and 85.3%, espectively. Concomitant injury was encountered more frequently (by 13% in the specialized-stage patients (73.7 and 60.7%, respectively. The severity of road traffic injury was determined mainly by brain injuries at the qualified irnd specialized stages (96.7 and 96.1%, by skeletal injuries (11.6% more frequently and thoracic ones (9.8% more frequently at the specialized stage. The prevalence of abdominal injuries at the qualified stage was 9.8% higher. The pattern of brain injury in the specialized-stage patients showed a preponderance of brain contusion and epidural hematomas by 18.5 and 6.5%, respectively. Conclusion. Severe thoracic and brain injuries (craniocerebral injuries, brain contusion, and intracranial hematomas are an indication for patient referral to the specialized care stage in order to perform high-technological diagnostic and therapeutic methods. Key words: children, road traffic accidents, severe injury, medical care stages.

  20. Memahami Patofisiologi dan Aspek Klinis Syok Hipovolemik: Update dan Penyegar

    Directory of Open Access Journals (Sweden)

    Hardisman Hardisman

    2013-09-01

    Full Text Available AbstrakSecara patofisiologis syok merupakan gangguan hemodinamik yang menyebabkan tidak adekuatnya hantaran oksigen dan perfusi jaringan. Gangguan hemodinamik tersebut dapat berupa penurunan tahanan vaskuler sitemik terutama di arteri, berkurangnya darah balik, penurunan pengisian ventrikel dan sangat kecilnya curah jantung. Gangguan faktor-faktor tersebut disbabkan oleh bermacam-macam proses baik primer pada sistim kardiovaskuler, neurologis ataupun imunologis. Diantara berbagai penyebab syok tersebut, penurunan hebat volume plasma intravaskuler merupakan faktor penyebab utama. Terjadinya penurunan hebat volume intravaskuler dapat terjadi akibat perdarahan atau dehidrasi berat, sehingga menyebabkan yang balik ke jantung berkurang dan curah jantungpun menurun. Penurunan hebat curah jantung menyebabkan hantaran oksigen dan perfusi jaringan tidak optimal dan akhirnya menyebabkan syok. Pada tahap awal dengan perdarahan kurang dari 10%, gejala klinis dapat belum terlihat karena adanya mekanisme kompensasi sisitim kardiovaskuler dan saraf otonom. Baru pada kehilangan darah mulai 15% gejala dan tanda klinis mulai terlihat berupa peningkatan frekuensi nafas, jantung atau nadi (takikardi, pengisian nadi yang lemah, penurunan tekanan nadi, kulit pucat dan dingin, pengisian kapiler yang lambat dan produksi urin berkurang. Perubahan tekanan darah sistolik lebih lambat terjadi akibat adanya mekanisme kompensasi tadi, sehingga pemeriksaan klinis yang seksama harus dilakukan.Kata kunci: syok, hipovolemik dan patofisiologiAbstractShock is hemodynamic disorders, which causes inadequate oxygen delivery and perfusion. The hemodynamic disorders can be decreasing of systemic vascular resistant, venous return, ventricular filling and inadequate of cardiac output. The disorders are caused by cardiovascular dysfunction, neurologic or immunologic factors. Intravascular volume loss is one of the main factors, which is caused by severe dehydration or bleeding. These

  1. Radioiodine therapy in patients with Graves' disease; Radioiodoterapia em pacientes com doenca de Basedow-Graves

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Margarida Maria Galvao; Blum, Bernardo; Pellegrini, Paulo Martins [Instituto Brasileiro de Medicina Nuclear, Rio de Janeiro, RJ (Brazil); Corbo, Rossana [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia; Rebello, Ana Maria de Oliveira [Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil). Servico de Medicina Nuclear

    2000-04-01

    We studied retrospectively 104 patients with Graves' disease who underwent radioiodine therapy between 1983 and 1993. The administered dose varied from 2.0 to 9.0 mCi (74 to 333 MBq). In 1994 and 1998 the patients were asked to answer a questionnaire and were considered to have hypothyroidism when receiving T4 therapy. The importance of radioiodine therapy, its indications and the different methods of calculating the administered activity were studied. The results were compared with the literature. At the end of the evaluation, 62,4% of the patients presented hypothyroidism and 37,6% euthyroidism. There was no significant difference regarding the development of hypothyroidism when sex, number of doses, total activity (mCi), effective radiation ({mu}Ci per gram of tissue) and use of antithyroid drugs were considered. In conclusion, the period of time of post-radioiodine therapy is the most important factor in the analysis of the results, which may interfere with the development of hypothyroidism. (author)

  2. Injuries to pedestrians in road traffic accidents.

    OpenAIRE

    Atkins, R. M.; Turner, W H; Duthie, R. B.; Wilde, B. R.

    1988-01-01

    Although there have been many reports on injuries to occupants of cars in road traffic accidents, there have been few prospective studies of injuries to pedestrians in such accidents. For this reason a two year prospective study of pedestrians in road traffic accidents in the Oxford region was carried out. The incidence of death in pedestrians was significantly higher than in car occupants or motorcyclists. The principal determinant of death was the weight of the vehicle concerned. The most c...

  3. Why Airplanes Crash: Causes of Accidents Worldwide

    OpenAIRE

    Oster, Clinton V.; John S. Strong; Zorn, Kurt

    2010-01-01

    In this paper, we report the results of a detailed examination of the causes of 700 fatal aviation accidents that occurred worldwide between 1990 and 2006 in commercial passenger service. We look at both scheduled and nonscheduled and both domestic and international service. We also categorize the accident aircraft as large jets, regional and medium jets, small jets, turboprops, and piston powered aircraft. We find that the mix of causes of those accidents vary substantially across regions of...

  4. Sifilis Laten: Diagnosis dan Pengobatan

    Directory of Open Access Journals (Sweden)

    Rasmia Rowawi

    2013-09-01

    Full Text Available Abstrak   Sifilis laten merupakan stadium sifilis yang diakibatkan oleh T. pallidum yang masih menetap dalam tubuh, namun tidak menunjukkan gejala dan hanya menunjukkan hasil pemeriksaan serologis yang reaktif. Sifilis laten yang tidak diterapi dapat menetap bertahun-tahun atau seumur hidup dan dapat meningkatkan risiko terinfeksi HIV. Ibu hamil dengan sifilis laten dini akan menyebabkan sekitar 40% bayi yang dilahirkankannya tertular, 20% prematur, 10% lahir mati, dan 4% meninggal pada waktu dilahirkan. Diagnosis sifilis laten dini ditegakkan bila dalam 12 bulan terakhir ditemukan satu atau lebih dari tanda-tanda berikut ini: peningkatan titer VDRL/RPR sebanyak empat kali atau lebih; pada anamnesis didapatkan gejala sifilis primer dan sekunder; riwayat kontak seksual dengan seseorang yang didiagnosis atau diduga menderita sifilis primer atau sifilis sekunder atau sifilis laten dini; serta kontak seksual dengan seseorang dengan tes VDRL atau RPR dan TPHA reaktif. Pengobatan yang direkomendasikan untuk sifilis laten dini adalah benzatin penisilin 2,4 juta UI, IM, dosis tunggal, sedangkan pada sifilis laten lanjut, benzatin penisilin 2,4 juta UI, IM, diberikan 3 kali dengan interval satu minggu. Pemeriksaan serologis sifilis non- treponemal (VDRL atau RPR dilakukan setelah pengobatan 3, 6, 12, dan 24 bulan untuk menilai keberhasilan pengobatan.   Kata kunci: Diagnosis, silifis laten, terapi

  5. COMMERCIAL SNF ACCIDENT RELEASE FRACTIONS

    Energy Technology Data Exchange (ETDEWEB)

    S.O. Bader

    1999-10-18

    The purpose of this design analysis is to specify and document the total and respirable fractions for radioactive materials that are released from an accident event at the Monitored Geologic Repository (MGR) involving commercial spent nuclear fuel (CSNF) in a dry environment. The total and respirable release fractions will be used to support the preclosure licensing basis for the MGR. The total release fraction is defined as the fraction of total CSNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. The radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses. This subset of the total release fraction is referred to as the respirable release fraction. Potential accidents may involve waste forms that are characterized as either bare (unconfined) fuel assemblies or confined fuel assemblies. The confined CSNF assemblies at the MGR are contained in shipping casks, canisters, or disposal containers (waste packages). In contrast to the bare fuel assemblies, the container that confines the fuel assemblies has the potential of providing an additional barrier for diminishing the total release fraction should the fuel rod cladding breach during an accident. However, this analysis will not take credit for this additional bamer and will establish only the total release fractions for bare unconfined CSNF assemblies, which may however be

  6. Sistem Komunikasi dan Informasi di Indonesia

    Directory of Open Access Journals (Sweden)

    Atie Rachmiatie

    2000-12-01

    Full Text Available Suatu Perubahan dan Tantangan Masa Depan Terdapat perubahan pola komunikasi dan informasi pada masyarakat. terutama perubahan dari segi perangkat keras, perangkat lunak. dan sumber daya manusia, yang berpengaruh terhadap sistem komunikasi dan informasi nasional, baik yang terjadi pada individu maupunpada lembaga/institusi yang berkaitan. Perubahan menyangkut pulapada kondisi organisasi pemerintah yang terkait dengan pengelolaan informasi. yaitu dengan ditata kembalinya sistem administrasi dan manajemen, baik secara intern, maupun ekstern berkaitan dengan organisasi luar. Apresiasi masyarakat terhadap materi informasi. pada kenyataannya. belum tersosialisasikan secara optimal. karena hal ini tergantung pada kebutuhan dan prioritas kebijakan institusi pemerintahan setempat. Dengan demikian. tidak semuajenis isi/materi informasi mendapatkan porsi yang sama dalam pemasyarakatannya.

  7. Relationship between childhood hyperactivity and accident proneness.

    Science.gov (United States)

    Gayton, W F; Bailey, C; Wagner, A; Hardesty, V A

    1986-10-01

    Previous research suggested that hyperactive children are especially susceptible to accidents. Two questions remain: is the relationship peculiar to hyperactivity in childhood or for behaviorally disturbed children in general and does the relationship hold for females as well as for males? To answer these questions 189 patients at a child psychiatric clinic were rated on a scale which included measures of hyperactivity and accident proneness. The hyperactive patients were more likely to be described as accident prone than nonhyperactive patients. The relationship between childhood hyperactivity and accident proneness is confirmed and is specific. The relationship holds for both boys and girls.

  8. Systematics of Reconstructed Process Facility Criticality Accidents

    Energy Technology Data Exchange (ETDEWEB)

    Pruvost, N.L.; McLaughlin, T.P.; Monahan, S.P.

    1999-09-19

    The systematics of the characteristics of twenty-one criticality accidents occurring in nuclear processing facilities of the Russian Federation, the United States, and the United Kingdom are examined. By systematics the authors mean the degree of consistency or agreement between the factual parameters reported for the accidents and the experimentally known conditions for criticality. The twenty-one reported process criticality accidents are not sufficiently well described to justify attempting detailed neutronic modeling. However, results of classic hand calculations confirm the credibility of the reported accident conditions.

  9. Methodological guidelines for developing accident modification functions

    DEFF Research Database (Denmark)

    Elvik, Rune

    2015-01-01

    This paper proposes methodological guidelines for developing accident modification functions. An accident modification function is a mathematical function describing systematic variation in the effects of road safety measures. The paper describes ten guidelines. An example is given of how to use...... limitations in developing accident modification functions are the small number of good evaluation studies and the often huge variation in estimates of effect. It is therefore still not possible to develop accident modification functions for very many road safety measures. © 2015 Elsevier Ltd. All rights...

  10. Occupational Accidents with Agricultural Machinery in Austria.

    Science.gov (United States)

    Kogler, Robert; Quendler, Elisabeth; Boxberger, Josef

    2016-01-01

    The number of recognized accidents with fatalities during agricultural and forestry work, despite better technology and coordinated prevention and trainings, is still very high in Austria. The accident scenarios in which people are injured are very different on farms. The common causes of accidents in agriculture and forestry are the loss of control of machine, means of transport or handling equipment, hand-held tool, and object or animal, followed by slipping, stumbling and falling, breakage, bursting, splitting, slipping, fall, and collapse of material agent. In the literature, a number of studies of general (machine- and animal-related accidents) and specific (machine-related accidents) agricultural and forestry accident situations can be found that refer to different databases. From the database Data of the Austrian Workers Compensation Board (AUVA) about occupational accidents with different agricultural machinery over the period 2008-2010 in Austria, main characteristics of the accident, the victim, and the employer as well as variables on causes and circumstances by frequency and contexts of parameters were statistically analyzed by employing the chi-square test and odds ratio. The aim of the study was to determine the information content and quality of the European Statistics on Accidents at Work (ESAW) variables to evaluate safety gaps and risks as well as the accidental man-machine interaction.

  11. Aerospace Accident - Injury Autopsy Data System -

    Data.gov (United States)

    Department of Transportation — The Aerospace Accident Injury Autopsy Database System will provide the Civil Aerospace Medical Institute (CAMI) Aerospace Medical Research Team (AMRT) the ability to...

  12. Accident Management in VVER-1000

    Directory of Open Access Journals (Sweden)

    F. D'Auria

    2008-01-01

    Full Text Available The present paper deals with the investigation study on accident management in VVER-1000 reactor type conducted in the framework of a European Commission funded project. The mentioned study involved both experimental and computational fields. The purpose of this paper is to summarize the main findings from the execution of a wide-range analysis focused on AM in VVER-1000 with main regard to the qualification of computational tools and the proposal for an optimal AM strategy for this kind of NPP.

  13. HTGR severe accident sequence analysis

    Energy Technology Data Exchange (ETDEWEB)

    Harrington, R.M.; Ball, S.J.; Kornegay, F.C.

    1982-01-01

    Thermal-hydraulic, fission product transport, and atmospheric dispersion calculations are presented for hypothetical severe accident release paths at the Fort St. Vrain (FSV) high temperature gas cooled reactor (HTGR). Off-site radiation exposures are calculated for assumed release of 100% of the 24 hour post-shutdown core xenon and krypton inventory and 5.5% of the iodine inventory. The results show conditions under which dose avoidance measures would be desirable and demonstrate the importance of specific release characteristics such as effective release height. 7 tables.

  14. KAJIAN BIOAKTIF DAN ZAT GIZI PROPOLIS INDONESIA DAN BRASIL

    Directory of Open Access Journals (Sweden)

    Eliza Halim

    2012-11-01

    Full Text Available ABSTRACTIndonesia has a potency to produce its own propolis, however the propolis market in Indonesia is dominated by imported product, such as from Brazil. Currently, still there is no reasearch which evaluate bioactive compound and nutrient content of Indonesian Propolis (IP compare with Brazilian Propolis (BP. The objectivesof this study were to analyze bioactive compounds and nutrient contents of IP compared to BP. Bioactive compounds and nutrients content were analyzed by gas chromatography–mass spectrophotometry. The resultsshowed both IP and BP contain fenol, α-amyrin, cylolanost, and pyrimidines. Bioactive compounds which specifically found in IP were eudesmane compound, ethyl acridine, lupeol, friedooleanan; while β amyrin and cinnamic acid compound only found in BP. The nutrient contents of IP were higher than BP except for vitamin A. In conclusion, IP might have potential health benefit, similar to BP.Key words: propolis, bioactive, nutrientABSTRAKIndonesia mempunyai potensi untuk menghasilkan propolis tetapi pemasaran propolis di Indonesia didominasi oleh propolis impor seperti propolis yang berasal Brasil. Sampai saat ini belum ada penelitian yang mengungkapkandungan bioaktif dan zat gizi propolis Indonesia (PI dibandingkan dengan propolis Brasil (PB. Oleh karena itu tujuan penelitian ini adalah untuk melakukan kajian kandungan bioaktif dan zat gizi (vitamin dan mineral PI dibandingkan dengan PB. Komponen bioaktif dan kandungn gizi dianalisis dengan metode gas chromatography–mass spectrometry. Hasil analisis menyatakan bahwa baik PI maupun PB mengandung senyawa fenol, α-amyrin, cylolanost, dan pirimidin. Komponen bioaktif unik yang ditemukan di dalam PI adalah senyawaeudesmane, ethyl acridine, lupeol dan friedooleanan; sedangkan β-amyrin dan senyawa asam sinamat hanya ditemukan di dalam PB. Kandungan zat gizi PI lebih tinggi dari PB kecuali kandungan vitamin A. Hal ini menunjukkan bahwa PI kemungkinan mempunyai khasiat untuk

  15. Accident Prediction Models for Akure – Ondo Carriageway, Ondo ...

    African Journals Online (AJOL)

    FIRST LADY

    Accident data on the 52km Akure-Ondo Carriageway and Spot Speed data were collected ... fatal accident and 62% non-fatal accident, However, the regression analysis ... corresponding vehicle kilometre of travel, commerce, and transportation ... of accident can provide insight into the causes that contributed to accident.

  16. PERBANDINGAN KARAKTERISTIK KIMIA KOPI LUWAK DAN KOPI BIASA DARI JENIS KOPI ARABIKA (Cafeea arabica. L) DAN ROBUSTA (Cafeea canephora. L)

    OpenAIRE

    Israyanti, -

    2012-01-01

    Penelitian ini bertujuan untuk mengetahui perbandingan jumlah kafein, karakteristik proksimat (protein dan lemak) dan rasa dan aroma antara kopi luwak dan kopi biasa dari jenis arabika (Cafeea arabica. L) dan robusta (Cafeea canephora. L). Perlakuan penelitian yakni A1 (luwak robusta), A2 (luwak arabika), B1 (robusta biasa) dan B2 (arabika biasa). Parameter penelitian yaitu pengujian organoleptik pada rasa (metode hedonik) dan aroma (metode ranking), analisa kafein dan uji proksimat berupa ...

  17. Current trends in the management of Graves' disease

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, B.; Glinoer, D.; Lagasse, R.; Wartofsky, L. (Walter Reed Army Medical Center, Washington, DC (USA))

    1990-06-01

    Members of the American Thyroid Association were invited to participate in a survey of the management of Graves' disease. One primary case and several variations were provided, which differed in respect to age, sex, goiter size, severity, etc. The questionnaire was based on the format used in a similar survey of members of the European Thyroid Association. The aim of the survey was to determine (1) how expert thyroidologist employ diagnostic procedures for this disorder, and (2) the choice of therapy of the three treatment options and its manner of implementation. Questionnaires were sent only to clinically active members. The overall response rate was 62%. Data analysis was possible on 52% of members surveyed and was performed using SPSS and a specific Fortran program. In the laboratory evaluation of the primary case a radioiodine uptake, scan, serum total T4, and basal TSH were requested by 92%, 47%, 83%, and 66%, respectively, with 84% of respondents using an ultrasensitive TSH assay. For management of the primary case, radioiodine treatment was the first choice of 69% of the respondents. Antithyroid drugs were used briefly (3-7 days) before 131I by 28%, whereas 41% said they would employ thioureas after 131I. Of those using 131I, 66% tailored the dose to achieve euthyroidism as the goal of therapy, while 34% aimed for hypothyroidism requiring T4 replacement. Only 30% of respondents chose thioureas as a first line of treatment (72% propylthiouracil; 28% tapazole). The duration of drug therapy was a predetermined fixed interval for 80% of the respondents, with 90% treating for 1-2 yr. Other specific trends in diagnostic approach and therapeutic preferences were identified for the eight variations on the primary case problem.

  18. Copy number variations exploration of multiple genes in Graves' disease.

    Science.gov (United States)

    Song, Rong-Hua; Shao, Xiao-Qing; Li, Ling; Wang, Wen; Zhang, Jin-An

    2017-01-01

    Few previous published papers reported copy number variations of genes could affect the predisposition of Graves' disease (GD). Herein, the aim of this study was to explore the association between copy number variations (CNV) profile and GD. The preliminary copy number microarray used to screen copy number variant genes was performed in 6 GD patients. Five CNV candidate genes (CFH, CFHR1, KIAA0125, UGT2B15, and UGT2B17) were then validated in an independent set of samples (50 GD patients and 50 matched healthy ones) by the Accucopy assay method. The CNV of the other 2 genes TRY6 and CCL3L1 was investigated in 144 GD patients and 144 healthy volunteers by the definitive genotyping technique using the Taqman quantitative polymerase-chain-reaction (Taqman qPCR). TRY6 gene-associated single nucleotide polymorphism (SNP), rs13230029, was genotyped by the PCR-ligase detection reaction (LDR) in 675 GD patients and 898 healthy controls. There were no correlation of the gene copy number (GCN) of CFH, CFHR1, KIAA0125, UGT2B15, and UGT2B17 with GD. In comparison with that of controls, the GCN distribution of TRY6 and CCL3L1 in GD patients did not show significantly differ (P > 0.05). Furthermore, TRY6-related polymorphism (rs13230029) showed no difference between GD patients and controls. No correlation was found between CNV or SNP genotype and clinical phenotypes. Generally, there were no link of the copy numbers of several genes, including CFH, CFHR1, KIAA0125, UGT2B15, UGT2B17, TRY6, and CCL3L1 to GD. Our results clearly indicated that the copy number variations of multiple genes, namely CFH, CFHR1, KIAA0125, UGT2B15, UGT2B17, TRY6, and CCL3L1, were not associated with the development of GD.

  19. Lithium as an Alternative Option in Graves Thyrotoxicosis

    Directory of Open Access Journals (Sweden)

    Ishita Prakash

    2015-01-01

    Full Text Available A 67-year-old woman was admitted with signs and symptoms of Graves thyrotoxicosis. Biochemistry results were as follows: TSH was undetectable; FT4 was >6.99 ng/dL (0.7–1.8; FT3 was 18 pg/mL (3–5; TSI was 658% (0–139. Thyroid uptake and scan showed diffusely increased tracer uptake in the thyroid gland. The patient was started on methimazole 40 mg BID, but her LFTs elevated precipitously with features of fulminant hepatitis. Methimazole was determined to be the cause and was stopped. After weighing pros and cons, lithium was initiated to treat her persistent thyrotoxicosis. Lithium 300 mg was given daily with a goal to maintain between 0.4 and 0.6. High dose Hydrocortisone and propranolol were also administered concomitantly. Free thyroid hormone levels decreased and the patient reached a biochemical and clinical euthyroid state in about 8 days. Though definitive RAI was planned, the patient has been maintained on lithium for more than a month to control her hyperthyroidism. Trial removal of lithium results in reemergence of thyrotoxicosis within 24 hours. Patient was maintained on low dose lithium treatment with lithium level just below therapeutic range which was sufficient to maintain euthyroid state for more than a month. There were no signs of lithium toxicity within this time period. Conclusion. Lithium has a unique physiologic profile and can be used to treat thyrotoxicosis when thionamides cannot be used while awaiting elective radioablation. Lithium levels need to be monitored; however, levels even at subtherapeutic range may be sufficient to treat thyrotoxicosis.

  20. [Efficacy of treatment with I(131) in paediatric Graves disease].

    Science.gov (United States)

    Enes Romero, P; Martín-Frías, M; de Jesús, M; Caballero Loscos, C; Alonso Blanco, M; Barrio Castellanos, R

    2014-01-01

    Radioiodine is an important therapeutic option in young patients with Grave's disease (GD). In the United States it is a widespread therapy, but in Europe its use in paediatrics is still controversial. To report our experience in radioiodine therapy of paediatric GD patients and analyse its effectiveness and safety. We retrospectively studied our paediatric population (<18 years of age) with GD, diagnosed from 1982 to 2012. A curative option was offered to patients who did not respond to anti-thyroid drug (AT) at puberty. We analysed, the patient characteristics, TSH, T4, T3 and thyroid antibodies levels, AT response, remission post I(131), side effects, and hypothyroidism rates. A total of 50 patients were diagnosed with GD from 1982 to 2012. All patients received AT as initial treatment (mean duration: 35.3±25.9 months). Permanent remission was achieved in 46%. Thyroidectomy was performed in 5 patients, and 14 patients received I(131) (mean dose: 10.9±1.09 mCi). Remission with I(131) was obtained in 100%. The rate of permanent hypothyroidism was 90%. There was no progression of ophthalmopathy or side effects in any patients treated with I(131.) Radioiodine treatment of paediatric GD patients is safe, leads to complete remission at the expense of hypothyroidism, and does not exacerbate ophthalmopathy. It can be considered in patients older than 5 years, who do no not respond to AT or with significant side effects with this medication. Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  1. PERANAN KOMPETENSI INTI DALAM MERGER DAN AKUISISI

    Directory of Open Access Journals (Sweden)

    Dwi Sulistiani

    2013-11-01

    Full Text Available Dalam era globalisasi dan pedagangan  bebas dewasa ini strategi merger dan akuisisi  merupakan fenomena yang semakin marak dilakukan oleh para pelaku bisnis dan  semakin menarik untuk dicermati bersama. Untuk menjalankan perusahaan para manajemen perusahaan selalu dituntut menjaga pertumbuhan usahanya secara optimal. Penerapan strategi merger dan akuisisi merupakan jalan pintas untuk mewujudkan pertumbuhan usaha tanpa perusahaan perlu memulai dari awal suatu jenis usaha yang baru. Dalam suatu kondisi perusahaan yang kuat cenderung membeli perusahaan lain untuk meningkatkan daya saing dan penghematan biaya. Perusahaan yang terlibat dalam merger dan akuisisi akan dapat diperoleh pangsa pasar yang lebih besar dan efisiensi terhadap biaya. Perusahaan yang merasa tidak dapat bertahan hidup secara individual biasanya merelakan diri untuk menjadi target akuisisi. Merger dan akuisisi merupakan suatu realitas dan tantangan yang harus siap dihadapi oleh para pelaku usaha dalam era perdagangan bebas saat ini. Namun tingkat kesuksesan dalam melakukan kegiatan merger dan akuisisi juga sangat dipengaruhi oleh kondisi internal perusahaan meliputi sumber daya, kapabilitas dan kompetensi inti yang dimiliki oleh perusahaan. Tulisan ini akan mencoba memberikan pemahaman bahwa sumber daya, kapabilitas dan  kompetensi inti merupakan faktor penting dalam melakukan kegiatan penggabungan usaha yang pada akhirnya dapat menentukan tingkat keberhasilan proses merger dan akuisisi yang sedang dijalankan oleh perusahaan

  2. [Multiple injuries in mass accidents].

    Science.gov (United States)

    Wondrák, E

    1984-01-01

    The treatment starts with reanimation, managing the shock, followed by life-saving surgery on the central nervous system, chest, abdomen, large blood vessels and the uropoietic system. From the very beginning the therapy should be conducted on an intradisciplinary basis, first with the anaesthesiologist, later with other specialists as required. Once the patient's life has been saved, treatment of eyes, hands and systematic attention to extremities should follow. Shock has to be managed within 24 hours. Luxations of large joints should be reposed on the date of injury, open fractures closed, all fractures immobilized in favourable position. No extension should be applied in patients suffering from brain injuries; fractures of the femur should be fixed surgically by a second team in the course of the neurosurgical operation. A stomatologist's assistance makes general anaesthesia possible even with fractures of the jaw. In mass accidents the therapeutic plan for the polytraumatized should be fixed on the following day. A mass accident involving 35 injured treated within two and a half hours demonstrates this procedure in 7 polytraumatized persons.

  3. RANCANG BANGUN MODEL KOMPRESI DAN TARIK PERMODELAN SANDBOX DAN MANFAATNYA

    Directory of Open Access Journals (Sweden)

    Fahrudin Fahrudin

    2015-07-01

    Full Text Available Permodelan sandbox dibuat dengan system tektonik konvergen dan divergen dengan menggunakan pergerakan satu sumbu. Permodelan ini bertujuan untuk membuat alat mesin sandbox yang bisa digunakan untuk penelitian dan pengajaran. Mesin berhasil dibuat dan sudah diujicobakan. Ujicoba dengan menggunakan satu lapisan pasir yang diambil dari Formasi Ngrayong. Percobaan selanjutnya dengan beberapa lapisan. Percobaan dilakukan dengan pengamatan yang meliputi pengamatan permukaan dan penampang verikal. Pengamatan yang aspek morfologi, kelurusan struktur, dan perkembangan sesar yang terbentuk. Hasil percobaan menunjukkan bahwa pembentukan morfologi sangat berkaitan dengan pembentukan sesar. Struktur sesar dengan pola forward propagating thrust faults. Sesar tersebut disebabkan imbrikasi. Lipatan yang terbentuk akibat mekanisme propagasi sesar.[Design of Compression and Extensional of the Sandbox Model and Its Benefit] Divergent and convergent tectonic sytem can be studied from the sandbox modelling. This model has a axis of movement. Sandbox models itends to study the progress of structural geology such as fault and fold. We successfully made machine of sandbox. This machine has basal detachment from duraluminum. Material for model is taken by loose sand from Ngrayong Formation. This experiment focused to observation about morphology in surface and thrust or backthrust in subsurface. This experiment has compression system. Result of model was that morphological sequences associated with fault sequences. Fault is formed to have the pattern of forward propagating thrust faults. It’s caused by imbricate thrust system. Folding is formed by the mechanism of fault propagation folding. 

  4. MUWUJUDKAN BUDAYA POLITIK SANTUN, BERSIH DAN BERETIKA DALAM RANGKA MEMPERKOKOH KEHIDUPAN BERBANGSA DAN BERNEGARA

    Directory of Open Access Journals (Sweden)

    Wahyu Widodo

    2014-11-01

    Full Text Available Abstract Makalah ini membahas konsep budaya politik berpusat pada imajinasi (pikiran dan perasaan manusia yang merupakan dasar semua tindakan. Dalam rangka menuju arah pembangunan dan modernisasi suatu masyarakat akan menempuh jalan yang berbeda antara satu masyarakat dengan yang lain, dan itu terjadi karena peranan kebudayaan sebagai salah satu faktor. Budaya politik dapat membentuk aspirasi, harapan, preferensi, dan prioritas tertentu dalam menghadapi tantangan yang ditimbulkan oleh perubahan sosial politik. Pada gilirannya, disimpulkan bahwa peran budaya politik santun, bersih dan beretika dalam rangka memperkokoh kehidupan berbangsa dan bernegara menuju Indonesia baru adalah: pertama, etika politik dan pemerintahan mengandung misi kepada setiap pejabat dan elite politik untuk bersikap jujur, amanah, sportif, siap melayani, berjiwa besar, memiliki keteladanan, rendah hati, dan siap untuk mundur dari jabatan publik apabila terbukti melakukan kesalahan dan secara moral kebijakannya bertentangan dengan hukum dan rasa keadilan masyarakat. Kedua, perlu dilakukan upaya penanaman suatu kesadaran bahwa politik yang hendak kita perjuangkan bukan semata politik kekuasaan, melainkan suatu politik yang mengedepankan panggilan pengabdian demi kesejahteraan masyarakat luas, dialektika antara partai dan politikus serta masyarakat yang kritis. Ketiga, budaya politik santun, bersih dan beretika ini diperlukan karena dapat membuat para elite politik menjauhi sikap dan perbuatan yang dapat merugikan bangsa Indonesia. Akhirnya, disarankan agar dilaksanakan kembali pendidikan budi pekerti yang merupakan pondasi bagi pelaksanaan Civic Education agar tercipta generasi yang tidak hanya mau menjadi politisi, namun paham budaya dan etika politik.   Kata kunci: budaya politik, kehidupan berbangsa dan bernegara, menuju Indonesia baru

  5. Long-term sequential monitoring of controlled graves representing common burial scenarios with ground penetrating radar: Years 2 and 3

    Science.gov (United States)

    Schultz, John J.; Walter, Brittany S.; Healy, Carrie

    2016-09-01

    Geophysical techniques such as ground-penetrating radar (GPR) have been successfully used for forensic searches to locate clandestine graves and physical evidence. However, additional controlled research is needed to fully understand the applicability of this technology when searching for clandestine graves in various environments, soil types, and for longer periods of time post-burial. The purpose of this study was to determine the applicability of GPR for detecting controlled graves in a Spodosol representing multiple burial scenarios for Years 2 and 3 of a three-year monitoring period. Objectives included determining how different burial scenarios are factors in producing a distinctive anomalous response; determining how different GPR imagery options (2D reflection profiles and horizontal time slices) can provide increased visibility of the burials; and comparing GPR imagery between 500 MHz and 250 MHz dominant frequency antennae. The research site contained a grid with eight graves representing common forensic burial scenarios in a Spodosol, a common soil type of Florida, with six graves containing a pig carcass (Sus scrofa). Burial scenarios with grave items (a deep grave with a layer of rocks over the carcass and a carcass wrapped in a tarpaulin) produced a more distinctive response with clearer target reflections over the duration of the monitoring period compared to naked carcasses. Months with increased precipitation were also found to produce clearer target reflections than drier months, particularly during Year 3 when many grave scenarios that were not previously visible became visible after increased seasonal rainfall. Overall, the 250 MHz dominant frequency antenna imagery was more favorable than the 500 MHz. While detection of a simulated grave may be difficult to detect over time, long term detection of a grave in a Spodosol may be possible if the disturbed spodic horizon is detected. Furthermore, while grave visibility increased with the 2D

  6. Radiological accidents balance in medicine; Bilan des accidents radiologiques en medecine

    Energy Technology Data Exchange (ETDEWEB)

    Nenot, J.C.

    1995-12-31

    This work deals with the radiological accidents in medicine. In medicine, the radiation accidents on medical personnel and patients can be the result of over dosage and bad focusing of radiotherapy sealed sources. Sometimes, the accidents, if they are unknown during a time enough for the source to be spread and to expose a lot of persons (in the case of source dismantling for instance) can take considerable dimensions. Others accidents can come from bad handling of linear accelerators and from radionuclide kinetics in some therapies. Some examples of accidents are given. (O.L.). 11 refs.

  7. Key Characteristics of Combined Accident including TLOFW accident for PSA Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Gyung; Kang, Hyun Gook [KAIST, Daejeon (Korea, Republic of); Yoon, Ho Joon [Khalifa University of Science, Technology and Research, Abu Dhabi (United Arab Emirates)

    2015-05-15

    The conventional PSA techniques cannot adequately evaluate all events. The conventional PSA models usually focus on single internal events such as DBAs, the external hazards such as fire, seismic. However, the Fukushima accident of Japan in 2011 reveals that very rare event is necessary to be considered in the PSA model to prevent the radioactive release to environment caused by poor treatment based on lack of the information, and to improve the emergency operation procedure. Especially, the results from PSA can be used to decision making for regulators. Moreover, designers can consider the weakness of plant safety based on the quantified results and understand accident sequence based on human actions and system availability. This study is for PSA modeling of combined accidents including total loss of feedwater (TLOFW) accident. The TLOFW accident is a representative accident involving the failure of cooling through secondary side. If the amount of heat transfer is not enough due to the failure of secondary side, the heat will be accumulated to the primary side by continuous core decay heat. Transients with loss of feedwater include total loss of feedwater accident, loss of condenser vacuum accident, and closure of all MSIVs. When residual heat removal by the secondary side is terminated, the safety injection into the RCS with direct primary depressurization would provide alternative heat removal. This operation is called feed and bleed (F and B) operation. Combined accidents including TLOFW accident are very rare event and partially considered in conventional PSA model. Since the necessity of F and B operation is related to plant conditions, the PSA modeling for combined accidents including TLOFW accident is necessary to identify the design and operational vulnerabilities.The PSA is significant to assess the risk of NPPs, and to identify the design and operational vulnerabilities. Even though the combined accident is very rare event, the consequence of combined

  8. A Serious Game for Traffic Accident Investigators

    Science.gov (United States)

    Binsubaih, Ahmed; Maddock, Steve; Romano, Daniela

    2006-01-01

    In Dubai, traffic accidents kill one person every 37 hours and injure one person every 3 hours. Novice traffic accident investigators in the Dubai police force are expected to "learn by doing" in this intense environment. Currently, they use no alternative to the real world in order to practice. This paper argues for the use of an…

  9. Occupational blood exposure accidents in the Netherlands.

    NARCIS (Netherlands)

    Wijk, P.T.L. van; Schneeberger, P.M.; Heimeriks, K.; Boland, G.J.; Karagiannis, I.; Geraedts, J.; Ruijs, W.L.M.

    2010-01-01

    BACKGROUND: To make proper evaluation of prevention policies possible, data on the incidence and associated medical costs of occupational blood exposure accidents in the Netherlands are needed. METHODS: Descriptive analysis of blood exposure accidents and risk estimates for occupational groups. Cost

  10. Fatal traffic accidents and forensic medicine

    Directory of Open Access Journals (Sweden)

    Kazuhiko Kibayashi

    2014-07-01

    Full Text Available In the event of a traffic accident fatality, the death is reported as an “unusual death,” an inquest is conducted, and, if necessary, a forensic autopsy is performed to prove any causal relationship between the accident and the death, identify the vehicle at fault, and determine the cause of the accident. A forensic autopsy of a traffic accident fatality needs to both determine the cause of death and identify the mechanism of injury, an analytical task that requires observation of three major traffic accident factors: the body, the vehicles involved, and the scene of the accident. Also crucial to determining the cause of death is the process of looking into whether the people involved in the accident had any diseases that might affect their driving performance or were under the influence of alcohol or drugs. In order to reduce the number of people killed in traffic accidents, it will be important to promote joint research uniting forensic medicine, clinical medicine, automotive engineering, and road engineering, take measures to limit the impact of inebriated pedestrians and pedestrians suffering from dementia, and ensure proper screening of alcohol and illegal drug consumption in drivers.

  11. Accidents of bus drivers : an epidemiological approach

    NARCIS (Netherlands)

    M.L.I. Pokorny (Mirko); D.H.J. Blom (Dick)

    1985-01-01

    textabstractIn the history of accident research much emphasis has been laid on general statistics, different types of case studies concentrating on various personal factor-s, circumstantial influences etc. Often, in certain waves, the unequal initial liability theory (the accident proneness concept;

  12. Squeal Those Tires! Automobile-Accident Reconstruction.

    Science.gov (United States)

    Caples, Linda Griffin

    1992-01-01

    Methods use to reconstruct traffic accidents provide settings for real life applications for students in precalculus, mathematical analysis, or trigonometry. Described is the investigation of an accident in conjunction with the local Highway Patrol Academy integrating physics, vector, and trigonometry. Class findings were compared with those of…

  13. 48 CFR 36.513 - Accident prevention.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Accident prevention. 36.513 Section 36.513 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL... prevention. (a) The contracting officer shall insert the clause at 52.236-13, Accident Prevention,...

  14. Chapter 6: Accidents; Capitulo 6: Acidentes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-06-01

    The chapter 6 talks about the accidents with radiators all over the world, specifically, the Stimos, in Italy, 1975, San Salvador, in El Salvador, 1989, Soreq, in Israel, 1990, Nesvizh, in Byelorussian, 1991, in Illinois, US, 1965, in Maryland, US, 1991, Hanoi, Vietnam, 1992, Fleurus, in Belgium, 2006. Comments on the accidents and mainly the learned lessons.

  15. 22 CFR 102.8 - Reporting accidents.

    Science.gov (United States)

    2010-04-01

    ... Foreign Relations DEPARTMENT OF STATE ECONOMIC AND OTHER FUNCTIONS CIVIL AVIATION United States Aircraft Accidents Abroad § 102.8 Reporting accidents. (a) To airline and Civil Aeronautics Administration representatives. If a scheduled United States air carrier is involved the airline representatives concerned will...

  16. An introduction to serious nuclear accident chemistry

    OpenAIRE

    Mark Russell St. John Foreman

    2015-01-01

    A review of the chemistry occurring inside a nuclear power plant during a serious reactor accident is presented. This includes some aspects of the behavior of nuclear fuel, its cladding, cesium and iodine. This review concentrates on the chemistry of an accident in a water-cooled reactor loaded with uranium dioxide or mixed metal oxide fuel.

  17. Global estimates of fatal occupational accidents.

    Science.gov (United States)

    Takala, J

    1999-09-01

    Data on occupational accidents are not available from all countries in the world. Furthermore, underreporting, limited coverage by reporting and compensation schemes, and non-harmonized accident recording and notification systems undermine efforts to obtain worldwide information on occupational accidents. This paper presents a method and new estimated global figures of fatal accidents at work by region. The fatal occupational accident rates reported to the International Labour Office are extended to the total employed workforce in countries and regions. For areas not covered by the reported information, rates from other countries that have similar or comparable conditions are applied. In 1994, an average estimated fatal occupational accident rate in the whole world was 14.0 per 100,000 workers, and the total estimated number of fatal occupational accidents was 335,000. The rates are different for individual countries and regions and for separate branches of economic activity. In conclusion, fatal occupational accident figures are higher than previously estimated. The new estimates can be gradually improved by obtaining and adding data from countries where information is not yet available. Sectoral estimates for at least key economic branches in individual countries would further increase the accuracy.

  18. Mean-field theory for car accidents

    Science.gov (United States)

    Huang, Ding-Wei; Tseng, Wei-Chung

    2001-11-01

    We study analytically the occurrence of car accidents in the Nagel-Schreckenberg traffic model. We obtain exact results for the occurrence of car accidents Pac as a function of the car density ρ and the degree of stochastic braking p1 in the case of speed limit vmax=1. Various quantities are calculated analytically. The nontrivial limit p1-->0 is discussed.

  19. KORELASI ANTARA ISLAM DAN EKONOMI

    Directory of Open Access Journals (Sweden)

    Akmal Zainal Abidin

    2015-03-01

    Full Text Available CORELATION BETWEEN ISLAM AND ECONOMY. This paper aims to identifies about the correlation between economic and Islam. Islam is the perfect religion that governs all things in life, including the economy. This is evident with the concept of  well-being which is described in the al-Quran and Sunnah. Basically the goal of every human life is to prosper, although humans make sense of  well- being with a different perspective. Most understand economics assume that welfare is the welfare of  earthly material. But to make sense of well-being with the term al-Falah, is meaning holistic wellbeing and balance between material and spiritual dimensions. al-Quran and Sunnah have taught that the human being will be achieved if  living in balance between material and spiritual. This is because human life does not just stop in the life of this world, but there is still a second life that will be faced by humanity in the hereafter, and well-being will be achieved with the truth is that people can balance the needs of the world and the hereafter, and that is what is taught in Islamic economics. Keywords: Islam, Economy, Prosperity. Tulisan ini bertujuan untuk menjelasakn tentang korelasi antara ekonomi  dan  Islam.  Islam  adalah  agama  yang  sempurna  yang mengatur segala hal dalam kehidupan ini, termasuk juga ekonomi. Hal ini terbukti dengan konsep kesejahteraan yang dipaparkan dalam al-Quran dan Sunnah. Pada dasarnya tujuan hidup setiap manusia adalah untuk mencapai kesejahteraan, meskipun manusia memaknai kesejahteraan dengan perspektif  yang berbeda-beda. Sebagian besar paham ekonomi menganggap bahwa kesejahteraan adalah kesejahteraan material duniawi. Namun Islam memaknai kesejahteraan dengan istilah  Falah  yang  berarti  kesejahteraan  holistik  dan  seimbang antara dimensi material dan spiritual. Al-Quran dan Sunnah telah mengajarkan bahwa kesejahteraan akan tercapai jika manusia menjalani hidup secara seimbang antara material dan

  20. KINERJA KEPALA SEKOLAH DALAM KEGIATAN BIMBINGAN DAN KONSELING

    Directory of Open Access Journals (Sweden)

    Abu Bakar M.Luddin

    2014-06-01

    Abstrak: Kinerja Kepala Sekolah dalam Kegiatan Bimbingan dan Konseling. Penelitian ini bertujuan mendeskripsikan kinerja kepala sekolah dalam pelaksanaan kegiatan bimbingan dan konseling. Penelitian dilaksanakan di SMU Negeri 2 Kota Binjai, dengan memergunakan rancangan deskriptif kualitatif. Subjek penelitian adalah kepala sekolah, koordinator bimbingan dan konseling, dan guru pembimbing. Data di­kumpulkan dengan observasi, wawancara mendalam, dan kajian dokumen, dan selanjutnya dianalisis sete­lah melalui proses triangulasi antarsubjek dan informasi. Temuan penelitian menunjukkan bahwa kinerja kepala sekolah terkait dengan pelaksanaan kegiatan bimbingan dan konseling masih belum sepenuhnya sebagaimana yang diharapkan. Kepala sekolah perlu meningkatkan kinerjanya dalam menjalankan fungsi koordinasi dan kepengawasan untuk mencapai kegiatan bimbingan dan konseling yang efektif.

  1. Morbidade Materna Grave e Near Misses em Hospital de Referência Regional

    Directory of Open Access Journals (Sweden)

    Márcia Lait Morse

    Full Text Available OBJETIVO: Analisar perfil epidemiológico da morbidade materna grave/near miss em uma maternidade pública de referência regional, utilizando diferentes critérios identificadores. MÉTODOS: Trata-se de um estudo descritivo de corte transversal dos casos de morbidade materna grave/near miss realizado em Hospital de referência regional entre junho e outubro de 2009, identificados a partir dos livros de registro de internação da maternidade e análise dos prontuários clínicos. Foram estudadas mulheres que, durante a gestação, parto ou puerpério, apresentaram qualquer quadro clínico compatível com os critérios definidores de morbidade materna grave/near miss de Waterstone et al., Mantel et al. e Organização Mundial de Saúde. RESULTADOS: Entre as 1.544 internações foram identificadas 89 mulheres com morbidade materna grave, considerando os critérios adotados. As razões de morbidade materna grave/near miss variaram entre 81,4 a 9,4 por 1.000 NV, dependendo do critério utilizado. O índice de Mortalidade foi de 3,2%, chegando a 23% no critério da OMS. Das 89 mulheres, apenas 40% fizeram mais de seis consultas de pré-natal e 10% não realizaram qualquer consulta. Os marcadores mais encontrados foram a pré-eclâmpsia grave seguida de hemorragia grave, internação em UTI, Síndrome HELLP e eclâmpsia. Ocorreram três mortes maternas por causas obstétricas com RMM de 280/100.000 NV e uma morte tardia. O critério da OMS se mostrou mais específico, identificando os casos mais graves, enquanto o de Waterstone foi mais sensível. CONCLUSÃO: O estudo da morbidade materna grave/near miss em um hospital de referência regional pode contribuir para o conhecimento da magnitude deste evento, como também identificar suas características e condições clínicas mais frequentes, sendo extremamente importante para o enfrentamento da morbi-mortalidade materna.

  2. SPIRITUALITAS MURIA: AKOMODASI TRADISI DAN WISATA

    OpenAIRE

    Ahmad Falah

    2012-01-01

    Tradition of “nyekar” which is very familiar among Javanese society, especially in the grave yard Muria Kudus Central Java. This research revealed that most of the visitor of the grave are for getting tabarrukan , some kind safety and ease in any effort in their life, mastering any knowledge, and linuwih, getting for healing from any desease, and asking for blessing for their descendants. The visit to the grave impacted much to the society living, both economically and socially. In the perspe...

  3. Evaluation of Railway Level Crossing Attributes on Accident Causation in Lagos, Nigeria.

    Directory of Open Access Journals (Sweden)

    Adeolu O Dina

    2017-01-01

    Full Text Available Abstract The study examines the contribution of Railway Level Crossing (RLCphysical attributes to accident occurrence using the12 major level crossings within the Lagos metropolis. The 48km single track mainline section under consideration which barely make up 1.1% of the entire narrow gauge track network of the country within a 5 year period contributed about 45% of the total National crossing accidents recorded in Nigeria. The method of investigation involved recording the individual attributes of each RLC such asgates, pedestrian traffic, car traffic light, proximity of signage to crossing, vehicular traffic as dummy variables.The regression analysis  was used to measure their effect on accidents.The result indicates gates, pedestrians and the location of signage had significant impact on accidents occurrence at level crossings within Lagos metropolis. Based on the findings, enhancement of active warning systems among other recommendations was suggested as potent counter measures for RLC accident reduction. Abstrak Penelitian menguji tingkat kontribusi atribut fisik dari perlintasan jalan kereta api terhadap kejadian kecelakaan menggunakan 12 perlintasan utama dalam kota metropolis Lagos. 48 km jalan utama tunggal menjadi pertimbangan yang hampir meningkat 1.1% dari seluruh trek sempit jaringan negara dalam jangka waktu 5 tahun menyumbang sekitar 45% dari total kecelakaan perlintasan secara Nasional di Nigeria. Metode penelitian melibatkan catatan dari masing-masing atribut RLC seperti pintu gerbang, pejalan kaki, lampu lalu lintas mobil, kedekatan tanda penyebarangan, lalu lintas kendaraan sebagai variabel dumi. Analisis regresi digunakan untuk mengukur pengaruh dari atribut terhadap kecelakaan. Hasilnya menunjukkan pintu gerbang, pejalan kaki, dan lokasi tanda perlintasan mempunyai dampak signifikan pada kecelakaan dalam kota metropolis Lagos.Berdasarkan penemuan tersebut, perbaikan dari sistem peringatan aktif disarankan sebagai upaya

  4. IKLIM SEKOLAH DAN EFIKASI KENDIRI DALAM KALANGAN GURU BIMBINGAN DAN KAUNSELING SEKOLAH MENENGAH DI KELANTAN

    OpenAIRE

    Ibrahim, Hasliza; Ismail, Siti Noor; Kassim, Mohamad Adnan Mohamad; Mohamad, Suhaila

    2017-01-01

    Artikel ini bertujuan untuk mengenal pasti hubungan antara iklim sekolah dan efikasi kendiri guru bimbingan dan kaunseling di negeri Kelantan.  Responden kajian adalah terdiri daripada 181 orang guru bimbingan dan kaunseling Sekolah Menengah di negeri Kelantan.  Kajian rintis dijalankan ke atas 30 orang guru bimbingan dan kaunseling di daerah Tanah Merah.  Secara spesifiknya, kaedah kuantitatif digunakan untuk tujuan pengumpulan data.  Maklum balas melalui soal selidik telah diperolehi dan se...

  5. MARINE ACCIDENTS RESEARCHED THROUGH HUMAN FACTOR PRISMA

    Directory of Open Access Journals (Sweden)

    Branislav M Ćorović

    2013-07-01

    Full Text Available We are aware of a large number of marine accidents that result in numerous casualties and even deaths and substantial negative environmental effects. The objective of this paper is to indicate factors that contribute to human errors which is identified as the most frequent cause to marine accidents. Despite rapid technological development and safety legislation, this paper identifies the human factor as the waekest link in maritime safety system. This analysis could lead to decrease of vessel accidents. In addition, starting from the European Maritime Safety Agency data and by linear regression model application, we have obtained the trend of number of ships involved in marine accidents as well as the trend of lives lost in marine accidents  in and around European Union waters.

  6. [Clinical examinations for the traffic accident patients].

    Science.gov (United States)

    Hitosugi, Masahito

    2008-11-30

    Traffic accident is a leading cause of unintentional death and about six-thousands annually died in Japan. As about one-million of persons suffer from traffic injuries, most of them seek medical attention. Therefore, medical staffs have to find the injuries accurately and treat immediately. Furthermore, the cause of accident should also be considered; why the accident was occurred, human error of the driver? To solve these problems, clinical examinations were needed. Medical staffs have to understand the characteristics of the traffic injuries: severe and multiple blunt injuries, popular injuries can be estimated with considering the pattern of the accident. Because some of the accidents are occurred when the driver is under the influence of alcohol and other drugs, screening of these subjects should be performed. Because the public is largely unaware of the preventable nature of traffic injuries, in addition to diagnose and treat accurately, we medical staffs have to attend on the primary prevention of the traffic injuries.

  7. Review of Severe Accident Phenomena in LWR and Related Severe Accident Analysis Codes

    Directory of Open Access Journals (Sweden)

    Muhammad Hashim

    2013-04-01

    Full Text Available Firstly, importance of severe accident provision is highlighted in view of Fukushima Daiichi accident. Then, extensive review of the past researches on severe accident phenomena in LWR is presented within this study. Various complexes, physicochemical and radiological phenomena take place during various stages of the severe accidents of Light Water Reactor (LWR plants. The review deals with progression of the severe accidents phenomena by dividing into core degradation phenomena in reactor vessel and post core melt phenomena in the containment. The development of various computer codes to analyze these severe accidents phenomena is also summarized in the review. Lastly, the need of international activity is stressed to assemble various severe accidents related knowledge systematically from research organs and compile them on the open knowledge base via the internet to be available worldwide.

  8. Commercial SNF Accident Release Fractions

    Energy Technology Data Exchange (ETDEWEB)

    J. Schulz

    2004-11-05

    The purpose of this analysis is to specify and document the total and respirable fractions for radioactive materials that could be potentially released from an accident at the repository involving commercial spent nuclear fuel (SNF) in a dry environment. The total and respirable release fractions are used to support the preclosure licensing basis for the repository. The total release fraction is defined as the fraction of total commercial SNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. Radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses; this subset of the total release fraction is referred to as the respirable release fraction. Accidents may involve waste forms characterized as: (1) bare unconfined intact fuel assemblies, (2) confined intact fuel assemblies, or (3) canistered failed commercial SNF. Confined intact commercial SNF assemblies at the repository are contained in shipping casks, canisters, or waste packages. Four categories of failed commercial SNF are identified: (1) mechanically and cladding-penetration damaged commercial SNF, (2) consolidated/reconstituted assemblies, (3) fuel rods, pieces, and debris, and (4) nonfuel components. It is assumed that failed commercial SNF is placed into waste packages with a mesh screen at each end (CRWMS M&O 1999). In contrast to bare unconfined fuel assemblies, the

  9. Induction of animal model of Graves' disease in BALB/c mice

    Institute of Scientific and Technical Information of China (English)

    Zhu-fang Tian; Bing-yin Shi; Xiao-yan Wu; Li Xu

    2009-01-01

    Objective To construct an animal model of Graves' disease (GD) by immunizing BALB/c mice with hM12 cells co-expressing major histocompatibility complex (MHC) class Ⅱ molecules and human thyrotropin receptor (TSHR) molecules. Methods BALB/c mice in experimental group (H-2d) were immunized with hM12 cells Intraper-itoncally every 2 weeks for six times, while mice in control group were immunized with M12 cells. Five weeks later, the thyroids were histologically examined, and serum samples were tested for thyroid-stimulating antibodies (TSAb) and thyroid hormone levels. Results One BALB/c mouse in experimental group developed Graves'-like disease. Total T4 and T3 levels in this mouse were above the upper limit of normal, TSAb activity was displayed in its serum. The thyroid histologically showed the features of thyroid hyperactivity including thyrocyte hypercellularity and colloid absorption.None of control mice developed Graves'-like disease. Conclusion An animal model with some characteristics of human Graves' disease was successfully induced and the model will facilitate studies aimed directly at understanding the patho-genesis of autoimmunity in Graves' disease.

  10. Severe gangrene by cold agglutinemia Gangrena grave causada por crioaglutinina

    Directory of Open Access Journals (Sweden)

    Perla Vicari

    2004-03-01

    crioaglutininemia deve ser confirmada e tratada prontamente em função da risco de possíveis complicações graves.

  11. Kandidiasis di Mulut akibat Khemoterapi dan Penatalaksanaannya

    OpenAIRE

    2016-01-01

    Latar belakang: kandidiasis (kandidosis) adalah infeksi jamur yang disebabkan oleh spesies Candida biasanya Candida albicans. Faktor predisposisi yang memicu kandidiasis adalah terganggunya ekologi mulut karena antara lain pemakaian antibiotika, kortikosteroid, penyakit kronis dan keganasan, beberapa gangguan darah; terapi radiasi di leher dan kepala; khemoterapi; leukimia, obat sitotoksik, juga kebersihan mulut yang buruk. Tujuan: melaporkan kasus kandidiasis di mulut karena khemoterapi dan ...

  12. PEMBELAJARAN SENI TARI: AKTIF, INOVATIF DAN KREATIF

    OpenAIRE

    Gandes Nurseto

    2015-01-01

    Pendidikan seni tari perlu diberikan pada Sekolah Dasar karena keunikan, kebermaknaan terletak pada pemberian pengalaman estetik dalam bentuk berapresiasi dan menggunakan model pembelajaran yang PAIKEM Pembelajaran, Aktif, Inovatif, Kreatif, Efektif dan Menyenagkan dalam proses pembelajaran didalam kelas dari Standar Kompetensi dan Komptensi Dasar mengapresiasi karya seni tari tunggal nusantara yang bertujuan untuk mengenalkan karya seni tari daerah lain. Masalah dalam penelitian ini bagaiman...

  13. Analysis of Fukushima Daiichi Accident Using HFACS

    Energy Technology Data Exchange (ETDEWEB)

    Mohamed, Saeed Almheiri [Korea Advanced Institue of Science and Technology, Daejeon (Korea, Republic of)

    2013-10-15

    The shadow of Fukushima Daiichi nuclear power plant (NPP) accident is still too big and will last long. On the other hand, it could still teach us lots of lessons to better design and operate nuclear power plants. In this paper, we will be focusing on the Fukushima Daiichi accident, especially on human organizational factors. We will analyze the accident using Human Factors Analysis and Classification System (HFACS) in order to better understand the organizational climate of TEPCO{sup 1} and NISA{sup 2} that led to Fukushima Daiichi Accident. HFACS was developed for the U. S. aviation industry and has been used at many industries like the rail and mining industries. We found that the HFACS to be greatly beneficial in investigating the latent and organizational causes for the accident. The application results show that the causes of Fukushima Daiichi accident were spread out from sharp end (i.e. Unsafe Act) to blunt end (i. e. Organizational Influences). This means that the corresponding countermeasures should cover from front line staff to management. Thus, we managed to develop a better understanding on how to prevent similar errors or violations. The incident and near-miss have a lot of helpful information because it may show the actual and latent deficiencies of complex systems. We applied the HFACS into Fukushima Daiichi accident to better locate the causes related to both sharp and blunt ends of operation of NPP. In order to derive useful lessons from the accident analysis, the analyst should try to find the similarities not differences from the incident. It is imperative that whatever accident/incident analysis systems we use, we should fully utilize the disastrous Fukushima accident.

  14. Risiko Ergonomi Ketidaksesuaian Desain dan Ukuran Tempat Duduk Sepeda Motor terhadap Antropometri pada Mahasiswa

    Directory of Open Access Journals (Sweden)

    Zulkifli Djunaidi

    2015-04-01

    Full Text Available Transportasi merupakan hal yang sangat dibutuhkan dalam menunjang pembangunan nasional. Belum baiknya sistem transportasi massal di Indonesia, membuat masyarakat lebih memilih menggunakan kendaraan pribadi, seperti sepeda motor yang praktis dan ekonomis untuk digunakan. Namun, dalam menggunakan sepeda motor, aspek ergonomi dan kenyamanan bagi pengendara perlu untuk diperhatikan. Desain dan ukuran tempat duduk sepeda motor yang tidak sesuai dengan antropometri duduk statis pengendara dapat menimbulkan kelelahan pada pengendara dan mengakibatkan terjadinya kecelakaan. Tujuan dari penelitian ini adalah untuk mengetahui risiko ergonomi dari ketidaksesuaian antara desain dan ukuran tempat duduk sepeda motor dengan antropometri duduk statis. Untuk menganalisis risiko ergonomi, dilakukan penelitian dengan desain deskriptif analitik pada mahasiswa di sekitar lingkungan kampus Fakultas Kesehatan Masyarakat Universitas Indonesia pada bulan Oktober sampai dengan Desember 2009. Jumlah sampel sebanyak 100 orang responden, dibagi menjadi 50 orang laki-laki dan 50 orang perempuan. Sampel responden dipilih dengan metode cluster random sampling, sedangkan tipe sepeda motor dipilih berdasarkan yang paling banyak digunakan dengan metode simple stratified random sampling. Hasil penelitian menunjukkan bahwa terdapat ketidaksesuaian antara ukuran tempat duduk sepeda motor dengan antropometri duduk statis pada mahasiswa. Adanya ketidaksesuaian tersebut dapat mengakibatkan risiko ergonomi pada pengendara dan terjadinya kecelakaan lalu lintas. Ergonomic Risks of Incompatibility of Design and Size of Motorcycle Seat againts Anthropometry among College Students Transportation is something needed most to support national development. Bad mass transportation system in Indonesia, makes people prefer to use private vehicles, such as motorcycle which is practical and economical to use. However, riders need to consider ergonomic and comfortability aspects in using motorcycle

  15. Regulation Plans on Severe Accidents developed by KINS Severe Accident Regulation Preparation TFT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyun Tae; Chung, Ku Young; Na, Han Bee [KINS, Daejeon (Korea, Republic of)

    2016-05-15

    Some nuclear power plants in Fukushima Daiichi site had lost their emergency reactor cooling function for long-time so the fuels inside the reactors were molten, and the integrity of containment was damaged. Therefore, large amount of radioactive material was released to environment. Because the social and economic effects of severe accidents are enormous, Korean Government already issued 'Severe Accident Policy' in 2001 which requires nuclear power plant operators to set up 'Quantitative Safety Goal', to do 'Probabilistic Safety Analysis', to install 'Severe Accident Countermeasures' and to make 'Severe Accident Management Plan'. After the Fukushima disaster, a Special Safety Inspection was performed for all operating nuclear power plants of Korea. The inspection team from industry, academia, and research institutes assessed Korean NPPs capabilities to cope with or respond to severe accidents and emergency situation caused by natural disasters such as a large earthquake or tsunami. As a result of the special inspection, about 50 action items were identified to increase the capability to cope with natural disaster and severe accidents. Nuclear Safety Act has been amended to require NPP operators to submit Accident Management Plant as part of operating license application. The KINS Severe Accident Regulation Preparation TFT had first investigated oversea severe accident regulation trend before and after the Fukushima accident. Then, the TFT has developed regulation draft for severe accidents such as Severe accident Management Plans, the required design features for new NPPs to prevent severe accident against multiple failures and beyond-design external events, countermeasures to mitigate severe accident and to keep the integrity of containment, and assessment methodology on safety assessment plan and probabilistic safety assessment.

  16. Leukemia following the Chernobyl accident.

    Science.gov (United States)

    Howe, Geoffrey R

    2007-11-01

    The accident at the Chernobyl Nuclear Power Plant in Ukraine in 1986 led to a substantial increase of thyroid cancer among those exposed as children. The other cancer that is the most sensitive to the effects of ionizing radiation is leukemia, and this paper evaluates the evidence relating exposure to Chernobyl radioactivity and leukemia risk. Two types of objectives are identified, namely, scientific evidence and public health, and two approaches to addressing such objectives are discussed. Empirical studies in affected populations are summarized, and it is concluded that, possibly apart from Russian cleanup workers, no meaningful evidence of any statistical association between exposure and leukemia risk as yet exists. However, it is important to carry on with such studies to satisfy various public health objectives.

  17. Pekerjaan, Nonpekerjaan, dan Psikologi Sosial sebagai Penyebab Kelelahan Operator Alat Berat di Industi Pertambangan Batu Bara

    Directory of Open Access Journals (Sweden)

    Indri Hapsari Susilowati

    2013-09-01

    Full Text Available Kelelahan merupakan salah satu faktor penyebab kecelakaan transportasi, ditandai dengan menurunnya kinerja fisik dan mental yang mengakibatkan kurangnya kewaspadaan karena rasa kantuk. Penelitian ini bertujuan untuk mengetahui faktor risiko dan faktor pendukung kelelahan pada operator alat berat. Penelitian dilakukan pada operator alat berat di 3 tambang batubara di Kalimantan (2 area di Kalimantan Timur dan 1 area di Kalimantan Selatan, melibatkan 353 operator alat berat yang bekerja dengan 3 sif. Hasilnya menunjukkan bahwa keluhan kelelahan semakin tinggi dengan meningkatnya usia, lama kerja, dan kerja pada sif 3 (malam hari. Kelelahan paling banyak dirasakan oleh operator dump truck (bagian hauling yang dipengaruhi oleh faktor-faktor pekerjaan (postur saat bekerja, faktor variasi pekerjaan, beban kerja dan vigilance dan faktor-faktor bukan pekerjaan (kondisi medan atau area tambang yang berisiko, penerangan yang kurang pada malam hari, dan rute yang selalu berubah. Faktor lainnya berkaitan dengan masalah sosial-psikologis, baik yang berhubungan dengan pekerjaan maupun lingkungan kerja, seperti waktu istirahat, standar gaji yang belum memadai, pengaturan jadwal cuti yang sering tidak jelas, dan masalah karier. Disimpulkan, secara umum kelelahan meningkat dengan bertambahnya usia dan lama kerja, dengan kelelahan yang lebih besar pada pekerja sif 3. Umumnya, penurunan waktu reaksi pekerja sif malam lebih besar daripada waktu reaksi pekerja sif siang. Fatigue is one of the causes of transportation accidents, characterized by reduced physical and mental performance resulting in reduced alertness due to drowsiness. The present study was to determine the risk factors and contributing factors of fatigue suffered by heavy equipment operators. The study was conducted at three coal mining sites in Kalimantan (2 areas in East Kalimantan and 1 area in South Kalimantan involving 353 heavy equipment operators who work in shifts. It was found that fatigue

  18. Image and Role of the Queen Mother of the West in Han Grave Art

    Directory of Open Access Journals (Sweden)

    Nataša VAMPELJ SUHADOLNIK

    2015-12-01

    Full Text Available The present article is a detailed study of the image of an ancient Chinese goddess, The Queen Mother of the West, called Xiwangmu 西王母 in Chinese. In the mythological tradition, Xiwangmu is a goddess who possesses the elixir of immortality and dwells in the western paradise, on the magic mountain Kunlun 崑崙. While her image can be found in mural paintings, and on lacquered objects and bronze mirrors, it appears primarily in the form of relief images on the stones and bricks of grave chambers and temples in the Han (206 BCE–220 CE grave complexes. The literary tradition reveals a multifunctional role of the mother, with her many attributes developing in accordance with the changing values of social and mythological concepts. The article concludes with a detailed discussion of her image and role within the wider cosmological context of Han grave art.

  19. Heterotopic relation between media and materiality in children's online memorials and on children's graves

    DEFF Research Database (Denmark)

    Sandvik, Kjetil; Christensen, Dorthe Refslund

    place across media. We show how the death of an infant can lead to mediation, remediation and mediatization strategies which involves both the uses and arrangement of objects on memorial pages and on children’s graves as well as uses of new social technologies, that produce, negotiate and develop social......In this paper we analyze how bereaved parents make use of various media-strategies on online memorial sites and on children’s graves when performing processes of grief and commemoration for their stillborns and infants, and how these processes are not just linked to one particular media but take...... relations with the dead child and the (re)negotiating of parenthood. We understand media as a function of an object reflected in human practices and embedded and structured by the different materialities they are intertwined with. We argue that the use of media and materiality online and on the graves are...

  20. Pollen studies of textile from an Iron Age grave at Hammerum, Denmark

    DEFF Research Database (Denmark)

    Enevold, Renée

    2013-01-01

    was rewarded with a set of results which permitted detailed interpretation. Large amounts of pollen of crops and associated anthropogenic plants in the textile sample suggest that agricultural work was the primary source of the pollen embedded in the clothing. In contrast, the pollen assemblages from......This article presents the methods employed and the results obtained in pollen studies of a prehistoric grave, identifying a fascinating and productive context for pollen analyses: prehistoric textiles. The methods involved direct sampling from the grave during excavation and various measures aimed...... at minimizing the risk of contamination, thereby maximising the information gained about various aspects of contemporary prehistoric life. The example used was an Iron Age grave from Hammerum, Denmark which was found to contain very well preserved clothing. The clothing and surrounding sediment were block...

  1. Mortality in Graves' orbitopathy is increased and influenced by gender, age and pre-existing morbidity

    DEFF Research Database (Denmark)

    Schwensen, Charlotte F; Hjelm Brandt Kristensen, Frans; Hegedüs, Laszlo

    2017-01-01

     = 3965) between 1995 and 2012 were matched for age and gender with four control subjects. Median follow-up time was 7.9 years (range 0-17.5). Mortality risk in GO patients compared to the control population and compared to GD patients was calculated using Cox regression analyses, adjusting for pre......INTRODUCTION: It is unclear whether the excess mortality associated with Graves' disease differs between individuals with Graves' orbitopathy (GO) or without (GD). SUBJECTS AND METHODS: A nationwide, register-based cohort study in which all adult Danes diagnosed with GD (n = 28 461) and GO (n......-existing morbidity using the Charlson score. RESULTS: Adjusted mortality in Graves' disease overall (GD + GO) was significantly increased compared to that in the background population (HR = 1.18 (95% confidence interval: 1.15-1.21)). In GD and GO separately, adjusted mortality was also significantly higher than...

  2. La communication organisante dans les systèmes à risques

    OpenAIRE

    Bouzon,Arlette

    2015-01-01

    Jusqu’à maintenant, la fiabilité des systèmes complexes a essentiellement résulté d’une approche dite « positiviste » qui consiste à prévoir et à maîtriser les risques par des ingénieurs et ergonomes durant leur conception. Or, à la suite d’incidents particulièrement graves, dans le domaine nucléaire notamment (Three Miles Island aux États-Unis en 1979 et Tchernobyl en URSS en 1986), des limites à cette approche sont apparues. Du fait de la complexification toujours croissante des systèmes ét...

  3. Pengaturan dan Pengawasan pada Bank Syariah

    Directory of Open Access Journals (Sweden)

    Ali Syukron

    2012-06-01

    Full Text Available Peran bank dalam melaksanakan tugas dan fungsinya perlu diatur secara baik dan benar. Hal ini bertujuan untuk menjaga kepercayaan nasabah terhadap aktivitas perbankan. Salah satu peraturan yang perlu dibuat untuk mengatur perbankan adalah peraturan mengenai permodalan bank yang berfungsi sebagai penyangga terhadap kemungkinan terjadinya kerugian. Tulisan ini merupakan studi pustaka dimana penulis mengelaborasi bagaimana pengaturan dan pengawasan pada bank syariah yang ada di berbagai negera. Dalam tulisan ini, penulis mengambil sampel negara Malaysia,  Pakistan, Kuwait, dan Inggris. Alasan memilih keempat negara tersebut karena Malaysia dan Kuwait memiliki kemiripan dengan Indonesia yang mengadopsi dual banking system.

  4. Reacciones adversas graves y mortales a los antimicrobianos. Sistema Cubano de Farmacovigilancia, 2003-2012

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    Ismary Alfonso Orta

    Full Text Available Introducción: las reacciones adversas a los antimicrobianos ocasionan más de 142 000 visitas a las salas de urgencias hospitalarias por año en los Estados Unidos. En Cuba han ocupado el primer lugar en el reporte, por ejemplo, en el año 2008 representaron el 31,4 % del total de las reacciones adversas graves y el 25 % de las reacciones adversas mortales. Objetivo: caracterizar las reacciones adversas graves y mortales a los antimicrobianos notificadas a la Unidad Nacional Coordinadora de Farmacovigilancia, durante el periodo 2003-2012. Métodos: se realizó un estudio de farmacovigilancia, observacional, descriptivo y transversal, utilizando la base de datos nacional de farmacovigilancia durante el periodo 2003-2012. Se trabajó con el total de reportes de reacciones adversas graves y mortales a los antimicrobianos. Las reacciones adversas se clasificaron según tipo de reacción, sistema de órgano afectado, imputabilidad y frecuencia. Se identificaron los principales antimicrobianos sospechosos y se estudiaron los pacientes que presentaron reacciones adversas según sexo y edad. Resultados: se detectaron 631 sospechas de reacciones adversas graves y mortales a los antimicrobianos, de ellas fueron 550 graves y 81 mortales. Predominaron el sexo femenino con 60,1 % y 405 adultos. Las reacciones adversas comprometieron los sistemas: general (30,4 %, respiratorio (25,2 % y cardiovascular (14,9 %. El shock anafiláctico fue la reacción más reportada y la penicilina el fármaco más relacionado con esta. El 73,5 % fueron probables y el 58,9 % ocasionales. Conclusiones: las reacciones adversas graves y mortales predominaron en el sexo femenino y en los adultos. La penicilina fue el fármaco más relacionado. Las reacciones adversas probables y ocasionales fueron la mayoría en el estudio.

  5. Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia?

    Directory of Open Access Journals (Sweden)

    Boyd Jonathan D

    2012-07-01

    Full Text Available Abstract Background Anterior mediastinal masses are a rare but well documented finding in Graves disease. The vast majority of these lesions represents benign thymic hypertrophy and regress after treatment of the hyperthyroidism. A small percentage of these cases however represent neoplastic/malignant diseases which require further treatment. Cases 12 year old boy with one year history of refractory Graves disease was found to have an anterior mediastinal mass and underwent curative thyroidectomy for sustained hyperthyroidism. Cervical lymphadenopathy was detected during the procedure and biopsy was obtained. A 23 year old woman who presented with a one month history of hyperthyroid symptoms, was diagnosed with Graves disease and also was found to have an anterior mediastinal mass on imaging. Biopsy of the anterior mediastinal mass was obtained and subsequently the patient underwent robotic thymectomy. Histologic examination and immunophenotyping of the cervical lymph node in a 12 year old boy revealed neoplastic proliferation of T lymphoblasts diagnostic of T lymphoblastic leukemia/lymphoma. Examination of the anterior mediastinal mass biopsy in the 23 year old woman revealed type B1 thymoma which was confirmed after examination of the subsequent robotic thymectomy specimen. Conclusion This is the first reported case of T cell lymphoblastic lymphoma and the third reported case of thymoma associated with sustained hyperthyroidism due to Graves disease. These cases indicate that an anterior mediastinal mass in a patient with active Graves disease may be due to a neoplastic cause, which may require definitive treatment. Caution should be exercised when dismissing a mediastinal mass as benign thymic hyperplasia in patients with active Graves disease.

  6. Road accidents and business cycles in Spain.

    Science.gov (United States)

    Rodríguez-López, Jesús; Marrero, Gustavo A; González, Rosa Marina; Leal-Linares, Teresa

    2016-11-01

    This paper explores the causes behind the downturn in road accidents in Spain across the last decade. Possible causes are grouped into three categories: Institutional factors (a Penalty Point System, PPS, dating from 2006), technological factors (active safety and passive safety of vehicles), and macroeconomic factors (the Great recession starting in 2008, and an increase in fuel prices during the spring of 2008). The PPS has been blessed by incumbent authorities as responsible for the decline of road fatalities in Spain. Using cointegration techniques, the GDP growth rate, the fuel price, the PPS, and technological items embedded in motor vehicles appear to be statistically significantly related with accidents. Importantly, PPS is found to be significant in reducing fatal accidents. However, PPS is not significant for non-fatal accidents. In view of these results, we conclude that road accidents in Spain are very sensitive to the business cycle, and that the PPS influenced the severity (fatality) rather than the quantity of accidents in Spain. Importantly, technological items help explain a sizable fraction in accidents downturn, their effects dating back from the end of the nineties.

  7. An analysis of aircraft accidents involving fires

    Science.gov (United States)

    Lucha, G. V.; Robertson, M. A.; Schooley, F. A.

    1975-01-01

    All U. S. Air Carrier accidents between 1963 and 1974 were studied to assess the extent of total personnel and aircraft damage which occurred in accidents and in accidents involving fire. Published accident reports and NTSB investigators' factual backup files were the primary sources of data. Although it was frequently not possible to assess the relative extent of fire-caused damage versus impact damage using the available data, the study established upper and lower bounds for deaths and damage due specifically to fire. In 12 years there were 122 accidents which involved airframe fires. Eighty-seven percent of the fires occurred after impact, and fuel leakage from ruptured tanks or severed lines was the most frequently cited cause. A cost analysis was performed for 300 serious accidents, including 92 serious accidents which involved fire. Personal injury costs were outside the scope of the cost analysis, but data on personnel injury judgements as well as settlements received from the CAB are included for reference.

  8. Accidents in Canada: mortality and hospitalization.

    Science.gov (United States)

    Riley, R; Paddon, P

    1989-01-01

    For Canadians under 45, accidents are the leading cause of both death and hospitalization. For the Canadian population as a whole, accidents rank fourth as a cause of death, after cardiovascular disease (CVD), cancer and respiratory disease. This article analyzes accident mortality and hospitalization in Canada using age-specific rates, age-standardized mortality rates (ASMR), and potential years of life lost (PYLL). The six major causes of accidental death for men are motor vehicle traffic accidents (MVTA), falls, drowning, fires, suffocation and poisoning. For women, the order is slightly different: MVTA, falls, fires, suffocation, poisoning and drowning. From 1971 to 1986, age-standardized mortality rates (ASMR) for accidents decreased by 44% for men and 39% for women. The largest decrease occurred in the under 15 age group. Accidents accounted for 11.5% of total hospital days in 1985, and 8% of hospital discharges. Because young people have the highest rates of accidental death, potential years of life lost (PYLL) are almost as high for accidents as for cardiovascular disease, although CVD deaths outnumbered accidental deaths by almost five to one in 1985.

  9. Professional experience and traffic accidents/near-miss accidents among truck drivers.

    Science.gov (United States)

    Girotto, Edmarlon; Andrade, Selma Maffei de; González, Alberto Durán; Mesas, Arthur Eumann

    2016-10-01

    To investigate the relationship between the time working as a truck driver and the report of involvement in traffic accidents or near-miss accidents. A cross-sectional study was performed with truck drivers transporting products from the Brazilian grain harvest to the Port of Paranaguá, Paraná, Brazil. The drivers were interviewed regarding sociodemographic characteristics, working conditions, behavior in traffic and involvement in accidents or near-miss accidents in the previous 12 months. Subsequently, the participants answered a self-applied questionnaire on substance use. The time of professional experience as drivers was categorized in tertiles. Statistical analyses were performed through the construction of models adjusted by multinomial regression to assess the relationship between the length of experience as a truck driver and the involvement in accidents or near-miss accidents. This study included 665 male drivers with an average age of 42.2 (±11.1) years. Among them, 7.2% and 41.7% of the drivers reported involvement in accidents and near-miss accidents, respectively. In fully adjusted analysis, the 3rd tertile of professional experience (>22years) was shown to be inversely associated with involvement in accidents (odds ratio [OR] 0.29; 95% confidence interval [CI] 0.16-0.52) and near-miss accidents (OR 0.17; 95% CI 0.05-0.53). The 2nd tertile of professional experience (11-22 years) was inversely associated with involvement in accidents (OR 0.63; 95% CI 0.40-0.98). An evident relationship was observed between longer professional experience and a reduction in reporting involvement in accidents and near-miss accidents, regardless of age, substance use, working conditions and behavior in traffic. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Doença de Graves associada à artrite idiopática juvenil Graves' disease associated with juvenile idiopathic arthritis

    Directory of Open Access Journals (Sweden)

    Vanessa de Matos Santos Mendonça Marques

    2011-04-01

    Full Text Available Os autores relatam o caso de uma menina de 10 anos de idade com diagnóstico de doença de Graves (DG, em tratamento com propiltiouracil, que desenvolveu uveíte e artrite poliarticular e cuja mãe também tem DG e lúpus discoide. São discutidos os diagnósticos diferenciais de artrite inflamatória que surge em uma criança com doença tireoidiana autoimune medicada com drogas antitireóideas.The authors report the case of a 10-year-old girl with Graves' disease (GD, treated with propylthiouracil, who developed uveitis and polyarticular arthritis, and whose mother also had GD and discoid lupus. The differential diagnosis of inflammatory arthritis that appears in a child with autoimmune thyroid disease managed with antithyroid drugs is discussed.

  11. ANALISIS PEMBELAJARAN HUMANIS DAN KONSTRUKTIVISKARAKTER, DAN KEMAMPUAN LITERASI MATEMATIKA

    Directory of Open Access Journals (Sweden)

    Muhammad Jazimul Ni’am

    2014-02-01

    Full Text Available AbstrakTujuan penelitian ini adalah untuk mengetahui pencapaian indikator teori humanismedankonstruktivismedalamperencanaan, bahanajar,danprosespembelajaranmateritrigonometri. Selainitu, ingindiketahui kemampuanliterasi matematikadankarakteryangmunculsebagaihasilbelajar.Penelitianinimerupakanpenelitiankualitatif.Instrumen yang disusun dan dikembangkan terdiri dari instrumen penila-ian perangkat pembelajaran,instrumen penilaian proses pembelajaran, tes kemampuanliterasimatematika,daninstrumenpenilaiankarakter.Validitasinstrumenpenelitianditentukanberdasarkan validasitimahli dan hasil tes uji cobadi lapangan.Teknikpengumpulandata yaitudenganmetode tes,observasi,wawancara,dan angket.Analisisdatadilakukan sebelum,selama, dan setelah penelitianberupaanalisisdiskriptif kualitatif.Keabsahan data hasil penelitian diuji menggunakan metode trianggulasidata. PenilaianterhadapRPP dan proses pembelajaranberada pada levelyangrendah, penilaian bahan ajar tergolong sedang jika dilihat daritiga aspek yaitupembelajaranhumanis,konstruktivis,dankemampuanliterasimatematika.Pencapaiankemampuan literasi matematikamasihdalam levelmenerjemahkanmasalahkontekstualkemodelmatematika dan belummampumencapai tahap menerapkandanmenafsirkan.Ketujuhkarakteryangdiamati belumsepenuhnyaterlihat. Karakteryangterlihat selamapembelajaran adalah jujur,toleransi,tanggungjawab,rasaingintahu, dan percayadiri.AbstractThe purpose of  this study was to determine the achievement indicators humanism andconstructivism theory in planning, teaching materials, and learning materials in matter trigonometry.In addition, it will be analyzedthe mathematical literacyskills andcharacterthatappearsas a resultof learning. This research is qualitative. The instrument was conceived anddeveloped is instrument to assess of  learning tools such as lesson plans and teaching materials, learning assessment, tests of  mathematical literacy skills, and instrument of  character. Validi-ty instruments of

  12. STRUKTUR DAN PRODUKSI LEBAH Trigona spp. PADA SARANG BERBENTUK TABUNG DAN BOLA

    Directory of Open Access Journals (Sweden)

    Putu Ade Hinduari Putra

    2015-12-01

    Full Text Available Lebah tanpa sengat (Trigona spp. dapat menghasilkan madu yang bermanfaat bagi kesehatan. Penelitian bertujuan untuk mengetahui : (1 morfologi Trigona spp., (2 struktur internal sarang Trigona spp. pada sarang berbentuk tabung dan bola, (3 volume sarang serta perkiraan produksi madu, beebread dan selanakan Trigona spp. pada sarang berbentuk tabung dan bola. Penelitian dilaksanakan pada bulan November 2014. Sampel yang digunakan adalah koloni dan sarang Trigona spp. berbentuk tabung dan bola yang diambil di Desa Padang Tunggal,Kecamatan Selat, Kabupaten Karangasem, Bali. Hasil penelitian menunjukan bahwa nama spesies dari sampel koloni Trigona spp. pada sarang berbentuk tabung dan bola adalah Trigona laeviceps. Struktur internal sarang Trigona spp. pada sarang berbentuk tabung dan bola mempunyai pola susunan yaitu pot madu, pot beebread dan pot sel anakan. Volume sarang besar memberikan perkiraan total jumlah produksi madu, beebread dan selanakan lebih banyak dibandingkan volume sarang kecil.

  13. PERAN KEPALA SEKOLAH DAN PUSTAKAWAN DALAM PEMBERDAYAAN PERPUSTAKAAN SD MUHAMMADIYAH SAPEN DAN SD NEGERI GIWANGAN

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    Widya Setyaningrum Bagyoastuti

    2016-04-01

    Full Text Available Penelitian ini bertujuan untuk mendeskripsikan: (1 peran kepala sekolah dalam memberdayakan perpustakaan sekolah dasar, dan (2 peran pustakawan dalam memberdayakan perpustakaan sekolah dasar. Pendekatan kualitatif digunakan dalam penelitian ini dengan menjadikan perpustakaan SD Muhammadiyah Sapen dan SD Negeri Giwangan sebagai subjek penelitian. Data penelitian dikumpulkan melalui teknik observasi, wawancara, dan dokumentasi kemudian dianalisis dengan mengacu pada model interaktif menurut Miles dan Huberman. Hasil penelitian menunjukkan bahwa pemberdayaan perpustakaan sekolah dasar dimulai manakala terdapat dukungan kepala sekolah dan hadirnya pustakawan penuh waktu yang profesional. Kepala sekolah berperan sebagai (1 manajer sekolah, (2 pemimpin instruksional, dan (3 agen perubahan. Pustakawan berperan sebagai (1 manajer perpustakaan, (2 ahli informasi dan penggiat literasi informasi, (3 pelaku instruksional, dan (4 kolaborator. Pemberdayaan perpustakaan dapat dilakukan dengan (1 meningkatkan partisipasi warga sekolah dalam pengembangan koleksi pustaka, (2 meningkatkan kolaborasi antara pustakawan dengan guru dalam pembelajaran, dan (3 pengembangan literasi informasi yang terintegrasi ke dalam pembelajaran.

  14. ETIKA BISNIS AL-GHAZALI DAN ADAM SMITH DALAM PERSPEKTIF ILMU BISNIS DAN EKONOMI

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    AM. M. Hafidz MS.

    2013-05-01

    Full Text Available Penelitian ini adalah untuk mengeksplorasi: (1 pembangunan etika bisnis yang telah dirumuskan oleh al-Ghazali dan Adam Smith, (2 persamaan dan perbedaan antara dua etika bisnis pria, dan (3 relevansi bisnis mereka etika bisnis modern dunia dan ekonomi. Bisnis etika dibangun oleh al-Ghazali dan Smith di dataran praksis tidak jauh berbeda. Etika bisnis konstruksi dibangun oleh al-Ghazali didasarkan pada prinsip-prinsip seperti orientasi itikad baik tentang dunia dan akhirat, kejujuran, kepentingan pribadi dan social keseimbangan, dan perilaku / perbuatan yang tepat. Di sisi lain, etika bisnis konstruksi dibangun oleh Smith, berdasarkan keadilan, altruisme, keadilan dan liberal (kebebasan ekonomi. Baik etika bisnis yang diperkenalkan oleh kedua sangat relevan untuk menjadi digunakan sebagai bahan pokok acuan dalam etika bisnis modern.

  15. PENGARUH PEMBERIAN HIJAUAN DAN KONSENTRAT MENGANDUNG UREA-KAPUR DAN UBI KAYU TERHADAP PENAMPILAN KAMBING PE

    Directory of Open Access Journals (Sweden)

    I G. Mahardika

    2015-06-01

    Full Text Available Penelitian telah dilakukan untuk mengetahui pengaruh pemberian hijauan dan konsentrat yang mengandung urea-kapur dan ubi kayu terhadap produktivitas kambing. Penelitian menggunakan Rancangan Acak Lengkap dengan 4 perlakuan dan 4 ulangan. Ke empat perlakuan yang dicobakan adalah Perlakuan A: ransum dengan 75% konsentrat (mengandung 4% urea, 2% kapur dan 50% ubikayu dan 25% hijauan (40% gamal dan 60% rumput raja, perlakuan B: rasnsum yang terdiri 60% konsentrat 40% hijauan, perlakuan C: ransum dengan 45% konsentrat dan 55% hijauan dan perlakuan D: ransum dengan 30% konsentrat dan 70% hijauan. Hasil penelitian mendapatkan bahwa produktivitas kambing yang mendapat ransum dengan level konsentrat 45% sampai 75% tidak berbeda sedangkan yang mendapat ransum dengan level konsentrat 30% lebih rendah. Ransum yang memebrikan nilai ekonomi tertinggi adalah ransum yang mengandung konsentrat antara 45% sampai 60%.

  16. IDENTIFIKASI DAN TEKNIK PENGENDALIAN HAMA DAN PENYAKIT BENIH PULAI (Alstonia scholaris

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    Evayusvita Rustam

    2016-09-01

    Full Text Available Tujuan dari penelitian ini adalah mengidentifikasi dan mengendalikan hama dan penyakit benih pulai yang terbawa dari lapangan. Identifikasi cendawan dilakukan dengan menginkubasi benih selama 7 hari, sedangkan untuk pengendalian terhadap hama dan penyakit benih diberi insektisida nabati dan kimia. Dari hasil identifikasi jenis cendawan pada benih pulai yaitu Aspergillus sp, Curvularia sp., Fusarium sp., Penicillium sp. dan Rhizopus sp. Persentase infeksi cendawan tertinggi pada benih pulai asal Nagrak (Aspergillus sp. sebesar 92%, Curvularia sp. 29% dan Fusarium sp. 21%, sedangkan persentase infeksi cendawan terendah pada benih pulai asal Jambi (Aspergillus sp. 2% dan Fusarium sp. 1%. Perlakuan terbaik yang dapat mengendalikan hama pada benih pulai adalah perlakuan yang diberi ekstrak daun suren dalam wadah plastik tertutup dan disimpan di ruang suhu kamar 270C selama 2 bulan. Pengendalian penyakit, terbaik pada benih adalah memberi bubuk kunyit ke dalam wadah plastik tertutup dan disimpan di lemari es 160C. Perlakuan tersebut menghasilkan daya kecambah masing-masing 70%.

  17. Bayes classifiers for imbalanced traffic accidents datasets.

    Science.gov (United States)

    Mujalli, Randa Oqab; López, Griselda; Garach, Laura

    2016-03-01

    Traffic accidents data sets are usually imbalanced, where the number of instances classified under the killed or severe injuries class (minority) is much lower than those classified under the slight injuries class (majority). This, however, supposes a challenging problem for classification algorithms and may cause obtaining a model that well cover the slight injuries instances whereas the killed or severe injuries instances are misclassified frequently. Based on traffic accidents data collected on urban and suburban roads in Jordan for three years (2009-2011); three different data balancing techniques were used: under-sampling which removes some instances of the majority class, oversampling which creates new instances of the minority class and a mix technique that combines both. In addition, different Bayes classifiers were compared for the different imbalanced and balanced data sets: Averaged One-Dependence Estimators, Weightily Average One-Dependence Estimators, and Bayesian networks in order to identify factors that affect the severity of an accident. The results indicated that using the balanced data sets, especially those created using oversampling techniques, with Bayesian networks improved classifying a traffic accident according to its severity and reduced the misclassification of killed and severe injuries instances. On the other hand, the following variables were found to contribute to the occurrence of a killed causality or a severe injury in a traffic accident: number of vehicles involved, accident pattern, number of directions, accident type, lighting, surface condition, and speed limit. This work, to the knowledge of the authors, is the first that aims at analyzing historical data records for traffic accidents occurring in Jordan and the first to apply balancing techniques to analyze injury severity of traffic accidents. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. [Treatment of hyperthyroidism due to Graves' disease: what is the recommended antithyroid drug during pregnancy?].

    Science.gov (United States)

    Caron, P

    2013-05-01

    Clinical hyperthyroidism during the first trimester of pregnancy due to Graves' disease can be associated with maternal, obstetrical and fetal complications, indicating an active treatment to restore normal thyroid function. Antithyroid drugs are the first line treatment in pregnant women with hyperthyroidism. Due to the increased congenital malformations reported in neonates after first-trimester carbimazole/methimazole treatment and propylthiouracil associated hepatotoxicity, the recommended treatment for pregnant women with hyperthyroid Graves' disease is propylthiouracil during the first trimester of pregnancy and following the first trimester, consideration should be given switching to carbimazole/methimazole during the second part of gestation.

  19. Cuidados intensivos en peritonitis grave: análisis de 9 años

    OpenAIRE

    Avilés Cruz, Pura

    1990-01-01

    Se realizó un estudio perspectivo de los cuidados intensivos en los en los enfermos de peritonitis grave, ingresados en el Hospital V. I. Lenin desde enero de 1980 a septiembre de 1988. Se estudiaron 446 pacientes, con los siguientes objetivos: comportamiento de la peritonitis grave, los criterios de reintervención en aquellos pacientes en que persistía la sepsis intraabdominal y las experiencias con la técnica de abdomen abierto. La evolución fue satisfactoria en el 63, 63%, y no satisfac...

  20. Patogenia y tratamiento médico de la orbitopatía de graves

    OpenAIRE

    Soledad Hidalgo, V.

    2010-01-01

    La Orbitopatía de Graves se presenta clínicamente en aproximadamente 50% de los casos de Enfermedad de Graves. La mayoría de las veces es leve y sólo en menos del 5% pone en riesgo la visión, pese a lo cual deteriora significativamente la calidad de vida de los pacientes. Hasta el momento no se conoce totalmente la patogenia, siendo posiblemente el receptor de TSH el blanco de la autoinmunidad. En cuanto al tratamiento, las medidas preventivas como lograr el eutiroidismo y la suspensión de...

  1. Epidemiología del traumatismo torácico grave

    OpenAIRE

    Cordero Lorenzana, María Lourdes

    2016-01-01

    [Resumen] Objetivo: Características del traumatismo torácico grave en UCI. Mortalidad. Material y método: Análisis descriptivo retrospectivo, univariado y regresión de 100 variables en 1174 pacientes con traumatismo torácico grave (1993-2010). Resultados: Más varones (4:1) de 43,5±18,9 años. 96,5% de traumatismos torácicos cerrados y 89% asociado. Lesiones óseas frecuentes: fracturas costales (71,2%) y claviculares (17,9%). Otras: contusión pulmonar (44%), hemotórax (41,7...

  2. Postpartum thyrotoxicosis in a patient with Graves' disease. Association with low radioactive iodine uptake

    Energy Technology Data Exchange (ETDEWEB)

    Eckel, R.H.; Green, W.L.

    1980-04-11

    A patient with previously diagnosed Graves' hyperthyroidism had a transient episode of thyrotoxicosis three months postpartum. This was associated with a diffusely enlarged thyroid gland, a rise in antithyroid microsomal antibody titer, a 24-hour radioactive iodine uptake (RAIU) of 1%, and an aspiration biopsy specimen suggestive of chronic lymphocytic thyroiditis. An alternative cause for the depressed RAIU was not discovered. This case would suggest that patients with previously diagnosed Graves' disease can have thyrotoxicosis without an enhanced RAIU and that the postpartum thyrotoxin syndrome may involve an immunologic injury causing a release of performed thyroid hormone.

  3. Management of hyperthyroidism due to Graves' disease: frequently asked questions and answers (if any).

    Science.gov (United States)

    Bartalena, L; Chiovato, L; Vitti, P

    2016-10-01

    Graves' disease is the most common cause of hyperthyroidism in iodine-replete areas. Although progress has been made in our understanding of the pathogenesis of the disease, no treatment targeting pathogenic mechanisms of the disease is presently available. Therapies for Graves' hyperthyroidism are largely imperfect because they are bound to either a high rate of relapsing hyperthyroidism (antithyroid drugs) or lifelong hypothyroidism (radioiodine treatment or thyroidectomy). Aim of the present article is to offer a practical guidance to the reader by providing evidence-based answers to frequently asked questions in clinical practice.

  4. THE FUNCTION AND PURPOSE OF AIRCRAFT ACCIDENT INVESTIGATION ACCORDING TO THE INTERNATIONAL AIR LAW

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    Atip Latipulhayat

    2015-10-01

    Full Text Available The main objective of an aircraft accident investigation is to find out the most probable causes of such accident. This represents a technical investigation in nature. At the practical level, however, this report is often used as legal evidence before the court. This paper argues that the main purpose of an aircraft acccident investigation is technical in nature and judicial investigation is carried out when the technical investigation found elements of crime that has been alleged as the most probable cause of the accident.   Menurut Konvensi Chicago 1944, tujuan utama suatu investigasi kecelakaan pesawat udara adalah untuk menemukan penyebab terjadinya kecelakaan tersebut. Jadi, investigasi ini bersifat teknis. Namun, laporan investigasi ini seringkali dijadikan alat bukti di pengadilan khususnya apabila faktor kesalahan manusia dianggap sebagai penyebab utama terjadinya kecelakaan tersebut. Investigasi teknis berubah menjadi investigasi yuridis. Tulisan ini berpendapat bahwa hakikat investigasi kecelakaan pesawat udara adalah bersifat teknis dan investigasi yuridis hanya akan dilakukan apabila laporan investigasi teknis menunjukkan adanya elemen kriminal.

  5. Sistem Informasi Penjualan dan Pemesanan Layanan Berbasis Web dan SMS Gateway di Petshop "PetZone"

    Directory of Open Access Journals (Sweden)

    Siska Fadhilah Wati

    2013-09-01

    Full Text Available Dewasa ini teknologi informasi sangat membantu dalam dunia bisnis. Kemudahan yang ditawarkan akan menjaring lebih banyak konsumen. Namun, perusahan tingkat menengah seperti PetZone saat ini masih jarang yang menawarkan kemudahan berbelanja atau pemesanan layanan secara online. Oleh karena itu diperlukan sebuah sistem berbasis web di perusahaan PetZone yang dapat memudahkan pemilik dan karyawan dalam apenjualan, pelayanan, dan pemasaran, serta memudahkan pelanggan dalam jual-beli barang dan jasa. Atas dasar masalah tersebut dibangun Sistem Informasi Penjualan dan Pemesanan Layanan Berbasis Web dan SMS Gateway untuk menunjang proses bisnis yang ada. Sistem informasi dibangun menggunakan bahasa pemrograman PHP framework Codeigniter, javascript untuk tampilan yang dinamis, dan database MySQL. Proses pembuatan dan pengembangan Sistem Informasi Penjualan ini menggunakan metode air terjun. Metode air terjun meliputi kebutuhan pengguna, analisis, rancangan, implementasi dan pengujian. Pemodelan Sistem Informasi yang dibangun menggunakan metode berorientasi objek UML (Unified Modeling Language yang terdiri dari Use case  diagram, Class diagram dan Sequence diagram. Hasil pengujian Sistem Informasi Penjualan dan Pemesanan Layanan Berbasis Web dan SMS Gateway menunjukkan bahwa semua fitur yang terdapat baik dalam sistem informasi maupun SMS gateway dapat bekerja dengan baikdengan ratusan sample data, dan server SMS gateway dapat memproses lebih dari satu SMS secara bersamaan. Dalam perkembangan ke depannya nanti, Sistem Informasi Penjualan dan Pemesanan Layanan Berbasis Web dan SMS Gateway masih dapat dikembangkan lagi dengan menambah fitur-fitur pada SMS gateway sehingga lebih memudahkan konsumen.

  6. PERANCANGAN DAN PENGEMBANGAN PROTOTYPE SISTEM PARKIR

    Directory of Open Access Journals (Sweden)

    Indah Ayu Septriyaningrum

    2016-10-01

    Abstrak  Sistem parkir manual pada pelayanan parkir mall memerlukan pengelolaan dan pengembangan sistem yang lebih rumit dan jauh dari kata efisien. Informasi yang didapatkan pengelola parkir terkait kondisi parkir di lapangan setiap harinya masih kurang. Tujuan dari penelitian ini adalah merancang dan mengembangkan prototype sistem parkir. Metode pengembangan dan perancangan sistem pada penelitian ini adalah metode Waterfall. Hasil yang didapatkan adalah sistem ini dapat mendeteksi keberadaan mobil pada slot parkir yang tersedia dengan bantuan Intel Galileo Board Gen 2 sebagai kontroler, sensor LDR (Light Dependent Resistor dan sensor ultrasonik (PING sebagai alat bantu pendeteksi keberadaan mobil. Sistem dapat menampilkan aktifitas parkir pada aplikasi web seperti kondisi lahan parkir kosong, lahan terisi, waktu masuk, waktu keluar, lama parkir dan kapasitas parkir yang tersedia serta grafik pemakaian lahan parkir. Dapat disimpulkan bahwa perancangan dan pengembangan sistem berhasil diimplementasikan. Kata Kunci : Sistem parkir, waterfall, Intel Galileo Board Gen 2,sensor LDR (Light Dependent Resistor, sensor ultrasonik

  7. ¿Hay diferencias entre la violencia grave y la violencia menos grave contra la pareja?: un análisis comparativo

    Directory of Open Access Journals (Sweden)

    Enrique Echeburúa

    2008-01-01

    Full Text Available En este estudio ex post facto se lleva a cabo una descripción de las características presentadas por 1.081 casos denunciados por violencia contra la mujer en las comisarías de la Ertzaintza del País Vasco. En primer lugar, se presentan las variables psicológicas y sociodemográficas del agresor y de la víctima, así como de la relación de pareja. Y en segundo lugar, se determinan las diferencias más significativas entre la violencia grave y la violencia menos grave en relación con esas mismas variables. Los resultados ponen de manifiesto que tanto los agresores como las víctimas tienden a ser jóvenes, con una sobrerrepresentación de agresores y víctimas extranjeros inmigrantes. En el caso de los maltratadores graves, tienden a ser celosos o posesivos, a sentirse humillados por la ruptura de la pareja, lo que redunda directamente en un descenso de su autoestima y a consumir abusivamente alcohol o drogas. Por lo que se refiere a las víctimas de la violencia grave, se suelen sentir con frecuencia en peligro de muerte y están más fácilmente en circunstancias de vulnerabilidad, como una edad muy joven, una personalidad muy dependiente, una situación de enfermedad crónica o de dependencia económica, un consumo de drogas o un entorno de soledad. Se comentan las implicaciones de este estudio para la investigación y para la práctica clínica.

  8. The Roma: People without a Home or Grave

    Directory of Open Access Journals (Sweden)

    Vera Klopčič

    2010-12-01

    Full Text Available Although the Roma have been living in Europe for centuries, they still face rejection by majority populations, being treated as undesirable strangers in almost all European countries. Written evidence of their arrival can be traced back to the fourteenth and fifteenth centuries. There are many legends and myths about their origins and reasons for emigrating from their country of origin. Until recently, the Roma transmitted their own history only as oral tradition. One of the best-known contemporary Roma intellectuals, journalist and writer Rajko Djurić, picturesquely explains the importance of the Romany language for further exploration of Roma culture and their origin: “Romany is the only book they brought from India; it constitutes their collective memory and reflects the views of this people, to themselves, to the world, and to other peoples. Their language is an inventory of the material and spiritual culture to which they once belonged, and contains elements of culture of other peoples that they came into contact with during their long and yet insufficiently studied journey.” When the Roma arrived in Europe, their lifestyle differed significantly from that of other European peoples. As a result, majorities and other groups in Europe intervened in their lives for centuries. They were forced to abandon their nomadic way of life. In the past, authorities often expelled them from their territory and they did not enjoy legal protection when violence or crimes were committed against them. Living in isolated settlements, excluded from social life, segregated, and discriminated against by others, they lived on the margins as a people without a home or a grave. At the same time, they established their parallel world as a system of social norms valid within their community, and within it all non-Roma were perceived as gadje ‘outsiders’. Roma legends explain the reasons for their nomadic way of life: they contain stories of persecution and

  9. KUALITAS PRODUK DAN KUALITAS LAYANAN TERHADAP KEPUASAN DAN LOYALITAS NASABAH

    Directory of Open Access Journals (Sweden)

    Kharisma Nawang Sigit

    2017-05-01

    Full Text Available This study described the effect of product quality and service quality on sustomer satisfaction and loyalty. The population in this study was the customers of Kredit Usaha Rakyat at BRI Warungasem. The sampling method used in this research was purposive sampling. The samples in this study were 100 customers in People’s Business Credit (Kredit Usaha Rakyat BRI Batang Branch Unit Warungasem who had already taken at least two time KUR credits. The instrument of answers measurement used was a Likert scale 1-7 alternative answers. Testing instrument used was validity and reliability, and testing the model used was the coefficient of determination and F test (goodness of fit. Testing the hypothesis in this study used t test. Variables used in the study were product quality, service quality, customer satisfaction and loyalty.The results showed that there was the effect on the product quality and customer satisfaction. Service quality affected the customer satisfaction. Product quality affect the customer loyalty. The quality of service had an effect on customer loyalty. Customer satisfaction had an effect on customer loyalty. Penelitian ini menjelaskan pengaruh kualitas produk dan kualitas layanan terhadap kepuasan nasabah dan loyalitas. Populasi pada penelitian ini adalah nasabah Kredit Usaha Rakyat BRI Unit Warungasem. Metode pengambilan sampel yang digunakan dalam penelitian ini adalah purposive sampling. Sampel dalam penelitian ini adalah 100 nasabah Kredit Usaha Rakyat di BRI Cabang Batang Unit Warungasem yang sudah mengambil minimal dua kali kredit KUR.Pengukuran jawaban instrumen menggunakan skala likert 1-7alternatif jawaban. Pengujian instrumen menggunakan validitas dan reliabilitas, pengujian model menggunakan koefisien determinasi, dan uji F (goodness of fit. Pengujian hipotesis dalam penelitian ini menggunakan uji t. Variabel yang digunakan dalam penelitian yaitu Kualitas Produk, kualitas layanan, kepuasan dan loyalitas nasabah. Hasil

  10. GRIYA DAN OMAH Penelusuran Makna dan Signifikasi di Arsitektur Jawa

    Directory of Open Access Journals (Sweden)

    Josef Prijotomo

    1999-01-01

    Full Text Available Terms and names in architecture may sometimes be powerful in exploring history of ideas. Philology and hermeneutics are discipline of knowledge that utilize this notion in a very throgh and critical way. Inspired by those discipline of knowledge, this musing on `Griya' and `Omah' tries to demonstrate that their meaning is not `house' as many still understand them. Rather, both terms understood by the Jawanese as `any building' constructed. Critical assessment upon old documents named `Kawruh Griya' not only supportive for this understanding among the Javanese, but also provide us with a hint on one of ideals of `what a home is' among the Jawanese. The Javanese once had a notion that to dwell in a house is like sheltering under a shady tree. Since `griya' and `omah' may open our musing up to regions and cultures outside Jawa, this paper will limit its musing within the Jawanese. Abstract in Bahasa Indonesia : Kata, sebutan dan istilah yang digunakan dalam arsitektur terkadang memiliki kemampuan untuk membantu dan menjadi bahan kajian sejarah bagi dunia arsitektur. Kajian filologi dan hermeneutika dengan baik telah memanfaatkan kemampuan tersebut. Tanpa harus memaksakan diri untuk mengikuti dengan ketat bidang pengetahuan tersebut, penelusuran atas arti `griya' dan `omah' ini mencoba untuk mengungkap sebagian kecil dari sejarah arsitektur Jawa. Melalui interpretasi-menerangkan (Poespoprodjo 1987: 194-195 atas arti kedua kata tersebut di dalam berbagai naskah Kawruh Griya, keduanya samasekali tidak memiliki arti: `rumah'. Dengan penelusuran ini ditemukan pula petunjuk yang mengarah pada salah satu gagasan orang Jawa tentang rumah yakni `bagaikan berteduh di bawah pohon'. Meskipun kedua kata tersebut dapat membawa penelusuran ini ke wilayah di luar arsitektur dan masyarakat Jawa, harus diakui bahwa penelusuran ini masih dibatasi pada telusuran internal bahasa Jawa, yakni hanya mengkaji kedua kata tersebut di dalam perjalanan kebahasaan bahasa Jawa

  11. 78 FR 31570 - Prospective Grant of a Start-Up Exclusive Patent License Agreement: Treatment of Graves' Disease...

    Science.gov (United States)

    2013-05-24

    ... a Start-Up Exclusive Patent License Agreement: Treatment of Graves' Disease, Hyperthyroidism and...' Disease, hyperthyroidism and thyroid cancer. DATES: Only written comments or applications for a license... useful in treating hyperthyroidism and Graves' disease, an autoimmune disease that is commonly...

  12. Symmetric increased skeletal muscular uptake of F-18 fluoro-deoxyglucose: A clue for the diagnosis of Graves' disease.

    Science.gov (United States)

    Santhosh, Sampath; Mittal, Bhagwant Rai; Kashyap, Raghava; Bhattacharya, Anish; Singh, Baljinder

    2011-07-01

    F-18 fluoro-deoxyglucose (FDG) uptake in the thyroid and thymus is well reported in patients with Graves' disease. Incidental skeletal muscle uptake has also been reported in other non-musculoskeletal (benign and malignant) pathologies. We report a patient of Graves' disease showing symmetrical skeletal muscle uptake but no thyroidal or thymus uptake of FDG.

  13. Pergaulan Bebas dan Hamil Pranikah

    Directory of Open Access Journals (Sweden)

    Farida Farida

    2009-06-01

    Full Text Available Married by accident cases or pragnancy outside marriage boundages and freeintercourse are blur pictures of our youth generation. In addition to break religious,social, and ethical norms, those acts also ruine their own futures. These cases happenusually because of lack of youth abilities to screen, to select and to choose positiverelationship. In addition, this is because of their unstable emotion, lack of partens’monitoring and less in religious knowledges. To prevent married by accident casesand effects of free intercourse, it is advisable for every families to strengthen faithof their family mambers, to build harmonious communication with the teenagers, toimprove diciplines in family circles, to control educatively and to direct the teenagersin performing positive activities, and to give sex education wisely and proportionally.Furthermore, schools and societies are expected to contribute in monitoring theteenagers so they are not cought up in free intercourse.Key Words: Married By Accident, Intercouse, Teenager, Religion

  14. Lõuka tuuliku restaureerimine / Dan Lukas

    Index Scriptorium Estoniae

    Lukas, Dan

    2005-01-01

    Hiiumaal Pühalepa vallas Vahtrepa külas Lõuka talu maadel asuva pukktuuliku ajaloost, restaureerimise käigust. Teostus: Dan Lukas. Muinsuskaitseline järelevalve: Tõnu Sepp, tema kommentaar. Ill.:pukktuuliku lõiked ja korruste plaanid, 7 värv. fotot

  15. Corner Office: Google's Dan Clancy

    Science.gov (United States)

    Albanese, Andrew Richard; Oder, Norman

    2009-01-01

    This article presents an interview with Dan Clancy, engineering director for Google Book Search. In this interview, Clancy talks about the pending Google Book Search settlement, involving millions of volumes digitized from libraries, which drew a lawsuit from the Association of American Publishers and the Authors Guild. He also discusses pricing,…

  16. Corner Office: Google's Dan Clancy

    Science.gov (United States)

    Albanese, Andrew Richard; Oder, Norman

    2009-01-01

    This article presents an interview with Dan Clancy, engineering director for Google Book Search. In this interview, Clancy talks about the pending Google Book Search settlement, involving millions of volumes digitized from libraries, which drew a lawsuit from the Association of American Publishers and the Authors Guild. He also discusses pricing,…

  17. HUKUM DAN PERUBAHAN MASYARAKAT

    Directory of Open Access Journals (Sweden)

    Antoni Antoni

    2015-05-01

    Full Text Available Abstract: Where there is sugar there must be an ant, or likefish and water, as it were appropriate parable likens the Lawand Society, because where there is society there must be lawswill be needed. Law and society are two sides of which aredifficult to separate, because they will need each other andinfluence each other.ملخص:حیث یوجد السكر یجب أن یكون ھناك نملة، أو مثل السمك والماء، كما انھاكانت مناسبة المثل یشبھ القانون والمجتمع، وذلك لأن عندما یكون ھناك مجتمع یجبأن یكون ھناك وستكون ھناك حاجة القوانین .القانون والمجتمع وجھان لوالتي یصعبفصل، لأنھا سوف نحتاج إلى بعضنا البعض وتؤثر على بعضھا البعض.Kata Kunci: hukum dan perubahan masyarakat

  18. Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre

    DEFF Research Database (Denmark)

    Bové, Kira Bang; Watt, Torquil; Vogel, Asmus

    2014-01-01

    ' disease compared to patients with another chronic thyroid disease, nodular goitre, and to investigate determinants of anxiety and depression in Graves' disease.METHODS: 157 cross-sectionally sampled patients with Graves' disease, 17 newly diagnosed, 140 treated, and 251 controls with nodular goitre......' disease versus 4% in nodular goitre (p = 0.038), anxiety was 18 versus 13% (p = 0.131). Symptoms of anxiety (p = 0.04) and depression (p = 0.01) increased with comorbidity. Anxiety symptoms increased with duration of Graves' disease (p = 0.04). Neither thyroid function nor autoantibody levels were...... associated with anxiety and depression symptoms.CONCLUSIONS: Anxiety and depression symptoms were more severe in Graves' disease than in nodular goitre. Symptoms were positively correlated to comorbidity and duration of Graves' disease but neither to thyroid function nor thyroid autoimmunity....

  19. The Chernobyl accident consequences; Consequences de l'accident de Tchernobyl

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-04-01

    Five teen years later, Tchernobyl remains the symbol of the greater industrial nuclear accident. To take stock on this accident, this paper proposes a chronology of the events and presents the opinion of many international and national organizations. It provides also web sites references concerning the environmental and sanitary consequences of the Tchernobyl accident, the economic actions and propositions for the nuclear safety improvement in the East Europe. (A.L.B.)

  20. 32 CFR 634.29 - Traffic accident investigation reports.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Traffic accident investigation reports. 634.29... records. Installation law enforcement officials will record traffic accident investigations on Service/DLA... traffic accident investigation reports pertaining to accidents investigated by military police that...

  1. 32 CFR 636.13 - Traffic accident investigation reports.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Traffic accident investigation reports. 636.13... Stewart, Georgia § 636.13 Traffic accident investigation reports. In addition to the requirements in § 634... record traffic accident investigations on DA Form 3946 (Military Police Traffic Accident Report) and DA...

  2. 46 CFR 4.03-1 - Marine casualty or accident.

    Science.gov (United States)

    2010-10-01

    ... States vessel wherever such casualty or accident occurs; or (3) With respect to a foreign tank vessel... 46 Shipping 1 2010-10-01 2010-10-01 false Marine casualty or accident. 4.03-1 Section 4.03-1... AND INVESTIGATIONS Definitions § 4.03-1 Marine casualty or accident. Marine casualty or accident...

  3. 48 CFR 852.236-87 - Accident prevention.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Accident prevention. 852... Accident prevention. As prescribed in 836.513, insert the following clause: Accident Prevention (SEP 1993....236-13, Accident Prevention. However, only the Contracting Officer may issue an order to stop all...

  4. Assessment of accident risks in the CRBRP. Volume 2. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-03-01

    Appendices to Volume I include core-related accident-sequence definition, CRBRP risk-assessment sequence-probability determinations, failure-probability data, accident scenario evaluation, radioactive material release analysis, ex-core accident analysis, safety philosophy and design features, calculation of reactor accident consequences, sensitivity study, and risk from fires.

  5. 46 CFR 196.30-5 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Accidents to machinery. 196.30-5 Section 196.30-5... Reports of Accidents, Repairs, and Unsafe Equipment § 196.30-5 Accidents to machinery. (a) In the event of an accident to a boiler, unfired pressure vessel, or machinery tending to render the further use...

  6. 46 CFR 97.30-5 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Accidents to machinery. 97.30-5 Section 97.30-5 Shipping... Reports of Accidents, Repairs, and Unsafe Equipment § 97.30-5 Accidents to machinery. (a) In the event of an accident to a boiler, unfired pressure vessel, or machinery tending to render the further use...

  7. 46 CFR 78.33-5 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Accidents to machinery. 78.33-5 Section 78.33-5 Shipping... Accidents, Repairs, and Unsafe Equipment § 78.33-5 Accidents to machinery. (a) In the event of an accident to a boiler, unfired pressure vessel, or machinery tending to render the further use of the...

  8. Gangguan Fungsi Penghidu dan Pemeriksaannya

    Directory of Open Access Journals (Sweden)

    Effy Huriyati

    2014-01-01

    Full Text Available AbstrakLatar belakang: Fungsi penghidu pada manusia memegang peranan penting. Gangguan penghidu dapat mempengaruhi keselamatan dan kualitas hidup seseorang. Tujuan: Untuk mengetahui jenis gangguan penghidu, penyebab gangguan penghidu, dan pemeriksaannya. Tinjauan Pustaka: Gangguan penghidu dapat berupa anosmia yaitu hilangnya kemampuan penghidu, atau hiposmia yaitu berkurangnya kemampuan penghidu. Gangguan penghidu disebabkan gangguan konduksi, gangguan sensoria dan gangguan neural. Penyakit tersering penyebab gangguan penghidu yaitu rinosinusitis kronis, rinitis alergi, infeksi saluran nafas atas dan trauma kepala. Ada beberapa modalitas pemeriksaan kemosensoris fungsi penghidu diantaranya Tes “Sniffin sticks”. Dengan tes „Sniffin sticks” dapat diketahui ambang penghidu, diskriminasi penghidu dan identifikasi penghidu seseorang. Kesimpulan: Gangguan penghidu memerlukan perhatian khusus. Diantara beberapa modalitas pemeriksaan kemosensoris penghidu, tes “Sniffin sticks” mempunyai beberapa kelebihan.Kata kunci: Gangguan penghidu, anosmia, hiposmia, tes “Sniffin sticks”.AbstractBackground: Olfactory function in humans plays an important role. Olfactory disorders can affect the safety and quality of life. Objective: To determine the type of olfactory disorder, the causes of olfactory disorders, and the examination. Literature Review: Olfactory disorder can be not smell anything or anosmia, and reduced of smell or hyposmia. Olfactory disorders caused by conduction disturbances, neural disturbances and sensoris disturbances. Disease that often causes disturbances of olfactory function is, chronic rhinosinusitis, allergic rhinitis, upper respiratory tract infections and head trauma. There are several modalities to examine chemosensoris smelling function, one of them is “Sniffin sticks” test. This test can examine threshold, discrimination, and identification of smelling. Conclusions: Impaired smelling require special attention

  9. PEMBINAAN DAN PENGEMBANGAN USAHA KECIL

    Directory of Open Access Journals (Sweden)

    Sentot Harman Glendoh

    2001-01-01

    Full Text Available Small business as an economic activity of society on a small scale, has a central role in the economy of Indonesia. Although the economic crisis has created a great disturbance in the live of large and middle-size business, apparently small business continues to function well in the lower levels of the economy. The main role of small business is: 1 use excess labor; 2 as a producer of goods and services at reachable prices for the lower economic levels of society; 3 as a potential producer of foreign exchange because of the success of this type of industry in producing non-oil commodities for export. Remembering that the role of small business is large and has great influence on the lower economic levels of society, it is quite necessary to pay attention to the development of this sector. Abstract in Bahasa Indonesia : Usaha kecil sebagai kegiatan ekonomi rakyat berskala kecil memiliki peran sentral dalam perekonomian Indonesia. Walaupun krisis ekonomi telah memporakporandakan kehidupan bidang usaha besar dan menengah, ternyata usaha kecil tetap tegar dan berjalan marak dikawasan kehidupan ekonomi tingkat bawah. Peran pokok usaha kecil ini adalah: (1 sebagai penyerap tenaga kerja, (2 sebagai penghasil barang dan jasa pada tingkat harga yang terjangkau bagi kebutuhan rakyat banyak yang berpenghasilan rendah, (3 sebagai penghasil devisa negara yang potensial kerena keberhasilannya dalam meproduksi komoditi ekspor non migas. Mengingat peran usaha kecil tersebut sangat besar andilnya bagi negara dan masyarakat kecil dilapisan bawah, maka pembinaan dan pengembangannya sangat perlu diperhatikan. Kata kunci: pembinaan, pengembangan, usaha kecil.

  10. The epidemiology of bicyclist's collision accidents

    DEFF Research Database (Denmark)

    Larsen, L. B.

    1994-01-01

    of bicyclists and risk situations. The findings should make a basis for preventive programmes in order to decrease the number and severity of bicyclists collision accidents. Data from the emergency room in a 2 year period was combined with data from questionnaires. The study group consisted of 1021 bicyclists...... group of accidents were the collisions with the 'soft' road users (bicyclists, mopeds, and pedestrians) and another group were the collisions with the 'hard' road users (motor vehicles, motorcycles). Preventive measures have to be directed at both these groups of accidents. To decrease the number...... of collision accidents with motor vehicles it is necessary to separate the bicyclists from the 'hard road traffic' especially at crossings. Preventive measures must also be directed at the bicyclists. Information must be given to warn the bicyclists against the risks, not only for collisions with motor...

  11. Review of methodology for accident consequence assessment

    Energy Technology Data Exchange (ETDEWEB)

    Strenge, D.L.; Soldat, J.K.; Watson, E.C.

    1978-09-01

    This report reviews current methodologies for reactor accident consequence analysis and describes areas where modifications are warranted. Methodologies reviewed are: (1) Models in Regulatory Guides 1.109, 1.111 and 1.113 used for evaluation of compliance with 10 CFR 50 Appendix I; (2) Models in Regulatory Guides used for evaluation of consequences from accidents of Classes 3-8; (3) Models for evaluation of Class 9 accidents presented in the Reactor Safety Study; and (4) Models in the Liquid Pathway Generic Study. The review is designed to aid in the ultimate goal of selection of a comprehensive set of models to extend the Class 9 methodology of the Reactor Safety Study to the analysis of Classes 3-8 accidents.

  12. Agricultural implications of the Fukushima nuclear accident

    National Research Council Canada - National Science Library

    Nakanishi, Tomoko M; Tanoi, Keitaro

    2013-01-01

    Following the Fukushima nuclear accident, a large volume of monitoring data has been collected about the soil, air, dust, and seawater, along with data about an immense number of foods supplied to the market...

  13. MELCOR analysis of the TMI-2 accident

    Energy Technology Data Exchange (ETDEWEB)

    Boucheron, E.A.

    1990-01-01

    This paper describes the analysis of the Three Mile Island-2 (TMI-2) standard problem that was performed with MELCOR. The MELCOR computer code is being developed by Sandia National Laboratories for the Nuclear Regulatory Commission for the purpose of analyzing severe accident in nuclear power plants. The primary role of MELCOR is to provide realistic predictions of severe accident phenomena and the radiological source team. The analysis of the TMI-2 standard problem allowed for comparison of the model predictions in MELCOR to plant data and to the results of more mechanistic analyses. This exercise was, therefore valuable for verifying and assessing the models in the code. The major trends in the TMI-2 accident are reasonably well predicted with MELCOR, even with its simplified modeling. Comparison of the calculated and measured results is presented and, based on this comparison, conclusions can be drawn concerning the applicability of MELCOR to severe accident analysis. 5 refs., 10 figs., 3 tabs.

  14. Safety analysis of surface haulage accidents

    Energy Technology Data Exchange (ETDEWEB)

    Randolph, R.F.; Boldt, C.M.K.

    1996-12-31

    Research on improving haulage truck safety, started by the U.S. Bureau of Mines, is being continued by its successors. This paper reports the orientation of the renewed research efforts, beginning with an update on accident data analysis, the role of multiple causes in these accidents, and the search for practical methods for addressing the most important causes. Fatal haulage accidents most often involve loss of control or collisions caused by a variety of factors. Lost-time injuries most often involve sprains or strains to the back or multiple body areas, which can often be attributed to rough roads and the shocks of loading and unloading. Research to reduce these accidents includes improved warning systems, shock isolation for drivers, encouraging seatbelt usage, and general improvements to system and task design.

  15. Review of models applicable to accident aerosols

    Energy Technology Data Exchange (ETDEWEB)

    Glissmeyer, J.A.

    1983-07-01

    Estimations of potential airborne-particle releases are essential in safety assessments of nuclear-fuel facilities. This report is a review of aerosol behavior models that have potential applications for predicting aerosol characteristics in compartments containing accident-generated aerosol sources. Such characterization of the accident-generated aerosols is a necessary step toward estimating their eventual release in any accident scenario. Existing aerosol models can predict the size distribution, concentration, and composition of aerosols as they are acted on by ventilation, diffusion, gravity, coagulation, and other phenomena. Models developed in the fields of fluid mechanics, indoor air pollution, and nuclear-reactor accidents are reviewed with this nuclear fuel facility application in mind. The various capabilities of modeling aerosol behavior are tabulated and discussed, and recommendations are made for applying the models to problems of differing complexity.

  16. Ruthenium release from fuel in accident conditions

    Energy Technology Data Exchange (ETDEWEB)

    Brillant, G.; Marchetto, C.; Plumecocq, W. [Inst. de Radioprotection et de Surete Nucleaire, DPAM, SEMIC, LETR and LIMSI, Saint-Paul-Lez-Durance (France)

    2010-07-01

    During a hypothetical nuclear power plant accident, fission products may be released from the fuel matrix and then reach the containment building and the environment. Ruthenium is a very hazardous fission product that can be highly and rapidly released in some accident scenarios. The impact of the atmosphere redox properties, temperature, and fuel burn-up on the ruthenium release is discussed. In order to improve the evaluation of the radiological impact by accident codes, a model of the ruthenium release from fuel is proposed using thermodynamic equilibrium calculations. In addition, a model of fuel oxidation under air is described. Finally, these models have been integrated in the ASTEC accident code and validation calculations have been performed on several experimental tests. (orig.)

  17. The Chornobyl accident: A comprehensive risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Vargo, G.J. [ed.; Poyarkov, V.; Bar`yakhtar, V.; Kukhar, V.; Los, I.; Kholosha, V.; Shestopalov, V.

    1999-10-01

    The authors, all of whom are Ukrainian and Russian scientists involved with Chornobyl nuclear power plant since the April 1986 accident, present a comprehensive review of the accident. In addition, they present a risk assessment of the remains of the destroyed reactor and its surrounding shelter, Chornobyl radioactive waste storage and disposal sites, and environmental contamination in the region. The authors explore such questions as the risks posed by a collapse of the shelter, radionuclide migration from storage and disposal facilities in the exclusion zone, and transfer from soil to vegetation and its potential regional impact. The answers to these questions provide a scientific basis for the development of countermeasures against the Chornobyl accident in particular and the mitigation of environmental radioactive contamination in general. They also provide an important basis for understanding the human health and ecological risks posed by the accident.

  18. [Severe parachuting accident. Analysis of 122 cases].

    Science.gov (United States)

    Krauss, U; Mischkowsky, T

    1993-06-01

    Based on a population of 122 severely injured patients the causes of paragliding accidents and the patterns of injury are analyzed. A questionnaire is used to establish a sport-specific profile for the paragliding pilot. The lower limbs (55.7%) and the lower parts of the spine (45.9%) are the most frequently injured parts of the body. There is a high risk of multiple injuries after a single accident because of the tremendous axial power. The standard of equipment is good in over 90% of the cases. Insufficient training and failure to take account of geographical and meteorological conditions are the main determinants of accidents sustained by paragliders, most of whom are young. Nevertheless, 80% of our patients want to continue paragliding. Finally some advice is given on how to prevent paragliding accidents and injuries.

  19. Bilateral Shoulder Dislocations Following a Motocross Accident

    National Research Council Canada - National Science Library

    H J Schroepfer; B M Martin; P J Millett

    2017-01-01

    .... A professional motocross racer experienced a high speed traumatic accident which resulted in bilateral shoulder dislocations with a rare associated complete anterosuperior RC tear due to a posterior dislocation...

  20. Severe accident recriticality analyses (SARA)

    DEFF Research Database (Denmark)

    Frid, W.; Højerup, C.F.; Lindholm, I.

    2001-01-01

    three computer codes and to further develop and adapt them for the task. The codes were SIMULATE-3K, APROS and RECRIT. Recriticality analyses were carried out for a number of selected reflooding transients for the Oskarshamn 3 plant in Sweden with SIMULATE-3K and for the Olkiluoto I plant in Finland...... with all three codes. The core initial and boundary conditions prior to recriticality have been studied with the severe accident codes SCDAP/RELAP5, MELCOR and MAAP4. The results of the analyses show that all three codes predict recriticality-both super-prompt power bursts and quasi steady-state power...... generation-for the range of parameters studied, i.e. with core uncovering and heat-up to maximum core temperatures of approximately 1800 K, and water flow rates of 45-2000 kg s(-1) injected into the downcomer. Since recriticality takes place in a small fraction of the core, the power densities are high...

  1. Learning lessons from Natech accidents - the eNATECH accident database

    Science.gov (United States)

    Krausmann, Elisabeth; Girgin, Serkan

    2016-04-01

    When natural hazards impact industrial facilities that house or process hazardous materials, fires, explosions and toxic releases can occur. This type of accident is commonly referred to as Natech accident. In order to prevent the recurrence of accidents or to better mitigate their consequences, lessons-learned type studies using available accident data are usually carried out. Through post-accident analysis, conclusions can be drawn on the most common damage and failure modes and hazmat release paths, particularly vulnerable storage and process equipment, and the hazardous materials most commonly involved in these types of accidents. These analyses also lend themselves to identifying technical and organisational risk-reduction measures that require improvement or are missing. Industrial accident databases are commonly used for retrieving sets of Natech accident case histories for further analysis. These databases contain accident data from the open literature, government authorities or in-company sources. The quality of reported information is not uniform and exhibits different levels of detail and accuracy. This is due to the difficulty of finding qualified information sources, especially in situations where accident reporting by the industry or by authorities is not compulsory, e.g. when spill quantities are below the reporting threshold. Data collection has then to rely on voluntary record keeping often by non-experts. The level of detail is particularly non-uniform for Natech accident data depending on whether the consequences of the Natech event were major or minor, and whether comprehensive information was available for reporting. In addition to the reporting bias towards high-consequence events, industrial accident databases frequently lack information on the severity of the triggering natural hazard, as well as on failure modes that led to the hazmat release. This makes it difficult to reconstruct the dynamics of the accident and renders the development of

  2. APRI-6. Accident Phenomena of Risk Importance

    Energy Technology Data Exchange (ETDEWEB)

    Garis, Ninos; Ljung, J (eds.) (Swedish Radiation Safety Authority, Stockholm (Sweden)); Agrenius, Lennart (ed.) (Agrenius Ingenjoersbyraa AB, Stockholm (Sweden))

    2009-06-15

    Since the early 1980s, nuclear power utilities in Sweden and the Swedish Radiation Safety Authority (SSM) collaborate on the research in severe reactor accidents. In the beginning focus was mostly on strengthening protection against environmental impacts after a severe reactor accident, for example by develop systems for the filtered relief of the reactor containment. Since the early 90s, this focus has shifted to the phenomenological issues of risk-dominant significance. During the years 2006-2008, the partnership continued in the research project APRI-6. The aim was to show whether the solutions adopted in the Swedish strategy for incident management provides adequate protection for the environment. This is done by studying important phenomena in the core melt estimating the amount of radioactivity that can be released to the atmosphere in a severe accident. To achieve these objectives the research has included monitoring of international research on severe accidents and evaluation of results and continued support for research of severe accidents at the Royal Inst. of Technology (KTH) and Chalmers University. The follow-up of international research has promoted the exchange of knowledge and experience and has given access to a wealth of information on various phenomena relevant to events in severe accidents. The continued support to KTH has provided increased knowledge about the possibility of cooling the molten core in the reactor tank and the processes associated with coolability in the confinement and about steam explosions. Support for Chalmers has increased knowledge of the accident chemistry, mainly the behavior of iodine and ruthenium in the containment after an accident.

  3. Health effects resulting from the Chernobyl accident.

    Science.gov (United States)

    Sumner, David

    2007-01-01

    This article reviews the health effects of the Chernobyl accident. The clearest effect to be seen to date is the dramatic increase in thyroid cancer in children. The evidence for increased leukaemia is less clear, but there are indications of increased leukaemia incidence in Russian clean-up workers. There is also evidence of increases in breast cancer, cataract and cardiovascular disease. However, to date the largest public health problem caused by the accident is the mental health impact.

  4. Personality characteristics of the child accident repeater

    OpenAIRE

    Manheimer, Dean I.; Mellinger, Glen D

    1997-01-01

    From 8874 boys and girls aged 4 to 18 in Berkeley-Oakland, California, 684 were selected to represent high-, intermediateor low-accident-liability children, based on records of medically attended injuries. Using data from intensive interviews with mothers supplemented with school records, we found a statistically significant relation between accident liability and indexes of extraversion, daring, roughhousing, and other traits tending to expose children to hazards. Similar relations held for ...

  5. Severe accident testing of electrical penetration assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Clauss, D.B. (Sandia National Labs., Albuquerque, NM (USA))

    1989-11-01

    This report describes the results of tests conducted on three different designs of full-size electrical penetration assemblies (EPAs) that are used in the containment buildings of nuclear power plants. The objective of the tests was to evaluate the behavior of the EPAs under simulated severe accident conditions using steam at elevated temperature and pressure. Leakage, temperature, and cable insulation resistance were monitored throughout the tests. Nuclear-qualified EPAs were produced from D. G. O'Brien, Westinghouse, and Conax. Severe-accident-sequence analysis was used to generate the severe accident conditions (SAC) for a large dry pressurized-water reactor (PWR), a boiling-water reactor (BWR) Mark I drywell, and a BWR Mark III wetwell. Based on a survey conducted by Sandia, each EPA was matched with the severe accident conditions for a specific reactor type. This included the type of containment that a particular EPA design was used in most frequently. Thus, the D. G. O'Brien EPA was chosen for the PWR SAC test, the Westinghouse was chosen for the Mark III test, and the Conax was chosen for the Mark I test. The EPAs were radiation and thermal aged to simulate the effects of a 40-year service life and loss-of-coolant accident (LOCA) before the SAC tests were conducted. The design, test preparations, conduct of the severe accident test, experimental results, posttest observations, and conclusions about the integrity and electrical performance of each EPA tested in this program are described in this report. In general, the leak integrity of the EPAs tested in this program was not compromised by severe accident loads. However, there was significant degradation in the insulation resistance of the cables, which could affect the electrical performance of equipment and devices inside containment at some point during the progression of a severe accident. 10 refs., 165 figs., 16 tabs.

  6. KINERJA DAN EFISIENSI BANK PEMERINTAH (BUMN DAN BUSN YANG GO PUBLIK DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Sugeng Haryanto

    2012-06-01

    Full Text Available Penelitian ini menganalisis kinerja dan tingkat efisiensi bank-bank BUMN dan BUSN yang go Publik di Bursa Efek Indonesia.  Sample penelitian ini mengambil  tiga bank BUMN Bank BNI 46, Bank Mandiri dan Bank BRI  dan tiga bank BUSN (Bank BCA, Bank Niaga dan Bank Panin dengan periode analisis tahun 2005-2011. Varibael yang digunakan meliputi ROA, ROE, LAR. LDR, NPL dan BOPO. Tujuan dari penelitian ini adalah melihat dan menganalisis perbedaan kinerja antara Bank BUMN dan BUSN yang go public di Bursa Efek Indonesia tahun 2005-2011.  Pendekatan pengukuran kinerja yang digunakan adalah Return on Asset (ROA, Return on Equity (ROE dan Loan to Deposit Ratio (LDR, Loan to Asset Ratio (LAR,  dan efisiensi bank. Hasil dari penelitian menunjukkan bahwa 1 Bank-bank nasional, baik itu bank BUMN maupun BUSN menunjukkan kinerja yang semakin baik, 2 tidak terdapat perbedaan yang signifikan antara kinerja bank BUMN dan BUSN untuk variabel ROA, ROE, LAR, LDR, dan BOPO sedangkan variabel NPL yang merupakan indikator risiko kredit menunjukkan adanya perbedaan yang signifikan antara Bank BUMN dan BUSN

  7. AGROFORESTRI UNTUK ADAPTASI DAN MITIGASI PERUBAHAN IKLIM

    Directory of Open Access Journals (Sweden)

    Tigor Butarbutar

    2017-01-01

    Full Text Available Hilangnya tutupan lahan hutan karena konversi hutan untuk pemukiman, perkebunan, pertanian dan kebutuhan untuk pembangunan di sektor lain, telah menyebabkan perubahan pola cuaca/iklim di berbagai tempat. Perubahan iklim dapat diantisipasi dengan mitigasi dan adaptasi. Mitigasi berarti usahausaha pencegahan yang perlu dilakukan, sedangkan adaptasi merupakan kegiatan-kegiatan penyesuaian yang perlu dilakukan untuk dapat hidup dan bertahan dan meningkatkan ketahanan, kelenturan dan mengarahkemigrasikarenakondisiiklimyangberbeda.Agroforestridapatmemitigasidanmengadaptasi perubahaniklim dengan alasan-alasansebagaiberikut: aPencampuranjenis pohonpenghasilkayu,buah dan lain-lain, karena campuran jenis lebih baik dari tanaman murni; b Pencampuran jenis yang didasarkan pada sifat toleransi ( dan , sehingga akan memanfaatkan seluruh cahaya untuk fotosintesis; c Pencampuran perbedaan umur; d Pencampuran berdasarkan perbedaan waktu pemanenan; e Penggabungan nilai ekonomi, sosial dan budaya sehingga perubahan vegetasi dapat berjalan seiring dengan perubahan sosial dan budaya secara berangsur yang dapat disesuaikan dengan perubahan iklim; dan f Dapat digunakan sebagai model untuk memfasilitasi perubahan kelompok vegetasi menjadi kelompok yang baru (adaptasi, seperti teori perubahan vegetasi melalui perladangan berpindah-pindahyangteratur.

  8. A Danish Early Germanic Iron Age Grave with Tablet Woven Cuffs

    DEFF Research Database (Denmark)

    Mannering, Ulla; Knudsen, Lise Ræder

    2007-01-01

    This article presents exciting new textile information from a Danish Early Germanic Iron Age grave at Broedbaek, North West Jutland, where tiny little fragments of textiles were found on metal clasps and brooches. Some of the textiles appeared to be made in a so far unknown tablet weaving technique....

  9. Outcome of inferior and superior rectus recession in Graves' orbitopathy patients

    NARCIS (Netherlands)

    Jellema, Hinke Marijke; Saeed, Peerooz; Groenveld, Linda; Kloos, Roel; Mourits, Maarten P

    2015-01-01

    PURPOSE: To evaluate the surgical effect of unilateral inferior rectus recession (IR-group) with or without a recession of contralateral superior rectus (IR-SR-group) on squint angle and motility restrictions in Graves' Orbitopathy (GO) patients. DESIGN: Retrospective case series. MATERIALS AND METH

  10. Graves' disease during immune reconstitution in HIV-infected patients treated with HAART.

    NARCIS (Netherlands)

    Vos, F.J.; Pieters, G.F.F.M.; Keuter, M.; Ven, A.J.A.M. van der

    2006-01-01

    Autoimmune phenomena after immune recovery due to HAART are not frequently described. Recently we found 3 patients with Graves' disease after starting HAART, outnumbering the expected incidence; 13 patients have been reported in the literature up to the present time.A probable relation between

  11. Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis

    DEFF Research Database (Denmark)

    Kristensen, Birte; Hegedüs, Laszlo; Lundy, Steven K

    2015-01-01

    A hallmark of regulatory B cells is IL-10 production, hence their designation as IL-10+ B cells. Little is known about the ability of self-antigens to induce IL-10+ B cells in Graves' disease (GD), Hashimoto's thyroiditis (HT), or other autoimmune disease. Here we pulsed purified B cells from 12 HT...

  12. Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis

    Directory of Open Access Journals (Sweden)

    Prindaville Brea

    2011-11-01

    Full Text Available Abstract Background Limited data are available on the association between vitiligo and autoimmune thyroid disease in pediatric patients. In addition, reported studies of pediatric patients have been based on a population known to have vitiligo and subsequently evaluated for the presence of thyroid function abnormalities. Methods A retrospective chart review was performed on 333 children who had been followed for thyroid disorders by endocrinologists at the Yale Pediatric Thyroid Center over the last 5 years for autoimmune thyroid disease. Demographical and clinical features of patients found to have thyroid disease and vitiligo were recorded. These studies were approved by the Yale Human Investigation Committee. Results Of the total 333 children and adolescents, 9 (2.7% were noted to have vitiligo. Four patients (44% had Graves' disease and 5 patients (66% had Hashimoto's thyroiditis. For patients with Graves' disease and vitiligo, the average age of onset of thyroid disease was young at 4 ± 0.7 years, and the diagnosis of vitiligo usually preceded that of thyroid disease. For children with Hashimoto's thyroiditis and vitiligo, thyroid disease was diagnosed at an average age of 13.25 ± 2.8 years. Conclusion In our population, 4.6% of children with Graves' disease and 2.0% of children with Hashimoto's thyroiditis had vitiligo. Interestingly, when vitiligo presents with Graves' disease, it occurs in younger rather than older children.

  13. Graves, Ancestors and Cement in Land disputes in Acholi and Ikland, Uganda

    DEFF Research Database (Denmark)

    Meinert, Lotte; Willerslev, Rane; Seebach, Sophie Hooge

    2017-01-01

    The paper explores the roles of graves, ancestors and concrete pillars in disputes over land across different land-systems, -conflicts, and territory making in northern Uganda by comparing extended cases between Acholi in Gulu district and Ik in Kaabong district . In the post-conflict Acholi region...

  14. T-cell prolymphocytic leukaemia (T-PLL): a rare disease with a grave prognosis.

    Science.gov (United States)

    Vivekanandarajah, Abhirami; Atallah, Jean Paul; Gupta, Shilpi

    2013-05-02

    T-cell prolymphocytic leukaemia (T-PLL) is an extremely uncommon haematological malignancy that has an aggressive course and a grave prognosis. We describe a patient who presented with lymphocytosis, scalp erythema, ascites and splenomegaly and was diagnosed with T-PLL. He was treated with alemtuzumab with a good response and was referred for allogeneic stem cell transplantation.

  15. Subclinical Hypothyroidism after 131I-Treatment of Graves' Disease: A Risk Factor for Depression?

    Directory of Open Access Journals (Sweden)

    Jing Yu

    Full Text Available Although it is well accepted that there is a close relationship between hypothyroidism and depression, previous studies provided inconsistent or even opposite results in whether subclinical hypothyroidism (SCH increased the risk of depression. One possible reason is that the etiology of SCH in these studies was not clearly distinguished. We therefore investigated the relationship between SCH resulting from 131I treatment of Graves' disease and depression.The incidence of depression among 95 patients with SCH and 121 euthyroid patients following 131I treatment of Graves' disease was studied. The risk factors of depression were determined with multivariate logistic regression analysis. Thyroid hormone replacement therapy was performed in patients with thyroid-stimulating hormone (TSH levels exceeding 10 mIU/L.Patients with SCH had significantly higher Hamilton Depression Scale scores, serum TSH and thyroid peroxidase antibody (TPOAb levels compared with euthyroid patients. Multivariate logistic regression analysis revealed SCH, Graves' eye syndrome and high serum TPO antibody level as risk factors for depression. L-thyroxine treatment is beneficial for SCH patients with serum TSH levels exceeding 10 mIU/L.The results of the present study demonstrated that SCH is prevalent among 131I treated Graves' patients. SCH might increase the risk of developing depression. L-thyroxine replacement therapy helps to resolve depressive disorders in SCH patients with TSH > 10mIU/L. These data provide insight into the relationship between SCH and depression.

  16. A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with mild Graves' ophthalmopathy

    NARCIS (Netherlands)

    Prummel, MF; Terwee, CB; Gerding, MN; Baldeschi, L; Mourits, MP; Blank, L; Dekker, FW; Wiersinga, WM

    2004-01-01

    Radiotherapy is often used in Graves' ophthalmopathy, but its efficacy has been doubted. We compared its efficacy with sham irradiation in mild ophthalmopathy. In a double-blind randomized trial, 44 patients received orbital irradiation, and 44 were sham-irradiated. The primary outcome was assessed

  17. 78 FR 16295 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Science.gov (United States)

    2013-03-14

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... the Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native American... the Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of a meeting of the Native...

  18. 77 FR 74874 - Native American Graves Protection and Repatriation Review Committee: Meeting

    Science.gov (United States)

    2012-12-18

    ... National Park Service Native American Graves Protection and Repatriation Review Committee: Meeting AGENCY... Federal Advisory Committee Act, 5 U.S.C. Appendix (1988), of a telephonic meeting of the Native American... Advisory Committee Act, 5 U.S.C. Appendix (1988), of a telephonic meeting of the Native American...

  19. A refined study of FCRL genes from a genome-wide association study for Graves' disease

    National Research Council Canada - National Science Library

    Zhao, Shuang-Xia; Liu, Wei; Zhan, Ming; Song, Zhi-Yi; Yang, Shao-Ying; Xue, Li-Qiong; Pan, Chun-Ming; Gu, Zhao-Hui; Liu, Bing-Li; Wang, Hai-Ning; Liang, Liming; Liang, Jun; Zhang, Xiao-Mei; Yuan, Guo-Yue; Li, Chang-Gui; Chen, Ming-Dao; Chen, Jia-Lun; Gao, Guan-Qi; Song, Huai-Dong

    2013-01-01

    To pinpoint the exact location of the etiological variant/s present at 1q21.1 harboring FCRL1-5 and CD5L genes, we carried out a refined association study in the entire FCRL region in 1,536 patients with Graves' disease (GD...

  20. Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease

    DEFF Research Database (Denmark)

    Brix, Thomas H; Hansen, Pia S; Hegedüs, Laszlo

    2008-01-01

    BACKGROUND: Yersinia enterocolitica (YE) infection has long been implicated in the pathogenesis of Graves' disease (GD). The association between YE and GD could, however, also be due to common genetic or environmental factors affecting the development of both YE infection and GD. This potential...

  1. Miastenia grave induzida por D-penicilamina em paciente com esclerose sistêmica progressiva

    Directory of Open Access Journals (Sweden)

    Paulo E. Marchiori

    1984-12-01

    Full Text Available Relato de caso de miastenia grave induzida por D-penicilamina. São descutidos os possíveis mecanismos etiopatogênicos envolvidos no desencadeamento da doença e é salientada a presença de anticorpo anti-receptor de acetilcolina e hiperplasia tímica na DPA-MG.

  2. Educational Interventions Targeted at Minors in Situations of Grave Social Vulnerability and Their Families

    Science.gov (United States)

    de la Caba Collado, Mariangeles; Rojas, Isabel Bartau

    2010-01-01

    The aim of this article is to outline and assess an educational intervention programme targeted at improving the skills of families and the personal and social development of children living in situations of grave social vulnerability. The sample comprised 10 families during the first phase of the intervention and six during the second. The…

  3. Eyelid retraction, lid lag, lagophthalmos, and von Graefe's sign quantifying the eyelid features of Graves' ophthalmopathy.

    Science.gov (United States)

    Gaddipati, Ramakrishna V; Meyer, Dale R

    2008-06-01

    To report the frequency and relationship of eyelid retraction, lid lag, lagophthalmos, and von Graefe's sign in a group of patients with Graves' ophthalmopathy and compare these findings to those in a group of normal individuals. Retrospective comparative cohort study. Fifty consecutive Graves' ophthalmopathy patients were compared to a control group of 50 normal individuals. Measurements were made of eyelid position in primary gaze and downgaze to assess eyelid retraction and lid lag, and the presence of lagophthalmos and von Graefe's sign was noted when present. Eyelid position in primary gaze and downgaze and presence of lagophthalmos and von Graefe's sign. In the Graves' group, eyelid retraction (38%), von Graefe's sign (36%) and lagophthalmos (16%) were observed at a significantly greater frequency (P<0.01) than in normals, whereas true eyelid lag was observed in only 8% (P = 0.67). The terms lid lag and von Graefe's sign have been used interchangeably in the past; however, they are distinct signs of downgaze-related upper eyelid static position and dynamic movement, respectively. Although von Graefe's sign was commonly exibited in Graves' patients, the relatively low frequency of lid lag suggests that factors other than restriction/fibrosis are likely responsible for the etiology of eyelid retraction in many cases.

  4. /sup 131/I-therapy of Graves' disease and non-immunogenic thyrotoxicosis

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschel, M.; Heinze, H.G.

    1984-06-01

    From 1977 to 1982, 315 patients suffering from thyrotoxicosis with diffuse and/or nodular goitre or Graves' disease were treated with /sup 131/I. In 246 patients, the results of treatment after 7 months to 5 1/2 years could be evaluated. After a single treatment with /sup 131/I, 72% of the patients with hyperthyroid nodular goitre and 61% of those with diffuse goitre, but only 36% of the patients with Graves' disease showed normal thyroid function. By repeated /sup 131/I treatments - as many as 5 for those with Graves' disease - normal thyroid function could be achieved in nearly all patients examined. Patients with immune thyrotoxicosis, type Graves' disease, showed a high resistance to therapy. A dependence was found between the results of these treatments and previous antithyroidal drug therapy or surgery. The rate of hypothyroidism varied between 4 and 15%. The highest rate of hypothyroidism was observed in operated patients with persistent or recurring thyrotoxicosis.

  5. Reporte de cinco casos de malaria neonatal grave por Plasmodium vivax en Urabá, Colombia

    Directory of Open Access Journals (Sweden)

    Juan Gabriel Piñeros

    2008-12-01

    Conclusión. Se trata de un reporte de cinco casos de malaria neonatal grave por P. vivax, especie que habitualmente no se relaciona con complicaciones, sin que existiera en ningún caso la sospecha clínica y con tratamiento inadecuado.

  6. B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study

    DEFF Research Database (Denmark)

    El Fassi, Daniel; Nielsen, Claus H; Bonnema, Steen J

    2007-01-01

    Graves' disease (GD) is a common TSH receptor autoantibody (TRAb)-mediated disorder. Because B lymphocytes are important self-antigen presenting cells and precursors for antibody-secreting plasma cells, temporary B-lymphocyte depletion with the monoclonal antibody rituximab (RTX) might be of bene...

  7. Educational Interventions Targeted at Minors in Situations of Grave Social Vulnerability and Their Families

    Science.gov (United States)

    de la Caba Collado, Mariangeles; Rojas, Isabel Bartau

    2010-01-01

    The aim of this article is to outline and assess an educational intervention programme targeted at improving the skills of families and the personal and social development of children living in situations of grave social vulnerability. The sample comprised 10 families during the first phase of the intervention and six during the second. The…

  8. Severe accident risks from external events

    Institute of Scientific and Technical Information of China (English)

    Randall O Gauntt

    2013-01-01

    This paper reviews the early development of design requirements for seismic events in USA early developing nuclear electric generating fleet.Notable safety studies,including WASH-1400,Sandia Siting Study and the NUREG-1150 probabilistic risk study,are briefly reviewed in terms of their relevance to extreme accidents arising from seismic and other severe accident initiators.Specific characteristic about the nature of severe accidents in nuclear power plant (NPP) are reviewed along with present day state-of-art analysis methodologies (methods for estimation of leakages and consequences of releases (MELCOR) and MELCOR accident consequence code system (MACCS)) that are used to evaluate severe accidents and to optimize mitigative and protective actions against such accidents.It is the aim of this paper to make nuclear operating nations aware of the risks that accompany a much needed energy resource and to identify some of the tools,techniques and landmark safety studies that serve to make the technology safer and to maintain vigilance and adequate safety culture for the responsible management of this valuable but unforgiving technology.

  9. FUNDING OF ACCIDENT INSURANCE IN UKRAINE

    Directory of Open Access Journals (Sweden)

    O. Gamankova

    2016-03-01

    Full Text Available The paper deals with the peculiarities of financial provision of public and private accident insurance. Analyzes the methodology of forming insurance premium rates in private accident insurance. The study examines the practice of reforming the financial security of the state social insurance against accidents. The results show need to implement scientifically proven approach to determining premium rates in the state social insurance based on mathematical statistics and actuarial calculations to ensure that such conditions on the one hand, can insure the risk, and the other - to provide the insurer the ability to perform insurance obligations' commitments. One of the promising areas of improvement Accident Insurance determines to define increasing the role of the private sector to create and attraction of investments, financing, reduce costs, and provision of insurance services on insurance against accidents at a qualitatively higher level. The results show the need to consider the usefulness of a mixed provision of services to accident insurance under state or non-state system, and the viability and effectiveness of the combination of these systems.

  10. CURRENT FACTORS OF ROAD ACCIDENTS IN ISFAHAN

    Directory of Open Access Journals (Sweden)

    B AMINMAN SOUR

    2000-06-01

    Full Text Available

    Introduction. Car accident mortality is the third order causes of death in the USA, following cardiovascular diseases and cancers. Given present survival and outcome Iranian data, more than 14,000 patients die annually in road accidents. Having a valid and reliable data could be useful in reduce mortality and morbidity reduction.
    Methods. Twenty five percent of total traumatic patients in Isfahan were selected (N=2809 at the time of study (1997-1998. Forty five percent of them with car accident were asked about causes of accidents and risk factors for the severity and type of injuries were recorded based on International Classification of Disease 10.
    Results. Most of the victims were young (10-20 years old, students and industrial workers. Statistically unreasonable numbers of cars without extension of roads and high ways, using old and unsafe cars will affects on accidents.
    Discussion. In comparison with European and some Asian countries, Iran has unacceptable road accidents and it seems necessary to pay more attention to stop the current increasing data.

     

  11. INDUSTRIALISASI DAN TANTANGANNYA PADA SEKTOR PENDIDIKAN

    Directory of Open Access Journals (Sweden)

    Arif Unwanullah

    2015-10-01

    Full Text Available Abstrak: Industrialisasi dan Tantangannya pada Sektor Pendidikan. Sumbangan pendidikan dalam perubahan dan pembangunan masa lalu telah bergeser dengan kemajuan teknoekonomi dan komunikasi. Perubahan yang terjadi telah menggeser tatanan kehidupan dan pandangan masyarakat. Materialisme, kapitalisme, efisiensi, dan efektivitas telah menjadi tujuan dan semangat hidup. Pergeseran pandangan masyarakat telah mengubah pula pandangan keberhasilan dan mutu pendidikan, di mana pendidikan diukur dari keberhasilan dalam keterserapan lulusan dalam dunia kerja, oleh karenanya pendidikan dianalisis dari karakteristik sebagai investasi (capital-investment. Pergeseran makna dan tanggung jawab pendidikan mendorong dunia pendidikan melakukan pembaruan dengan alternatif: membangun pembaruan penalaran warganya menuju pemerdekaan dan pendewasaan, pendidikan dilaksanakan secara komprehensif dan bekerjasama dengan semua pihak secara kemitraan, dan membangun visi pendidikan secara komprehensif dan simultan dengan semua pihak. Kata kunci: perubahan sosial, materialistik, modernisasi dan kapitalis Abstract: Industrialization and its education Sector challenges. Contribution of education has shifted with the progress of technology, economy, and communication. The changes have shifted the society's views. Materialism, capitalism, efficiency, and effectiveness have become of interest and enthusiasm for life. The shift has changed society's view, i.e. the view of success and quality of education, in which education is measured from a rate of the absorption of graduates into labor market, therefore education is analyzed from the characteristics of an investment (capital-investment. A shift in meaning and responsibility of education encourages the education sector to create reformation through these following alternatives: creating new thoughts towards liberation and maturation, implementing education comprehensively and cooperating with all parties in partnership, and creating

  12. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  13. IMPLEMENTASI KEBIJAKAN PEMUNGUTAN PAJAK BUMI DAN BANGUNAN

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    Arifuddin - Sahabu

    2012-05-01

    Full Text Available ABSTRAKS   Penelitian ini menggunakan metode kualitatif dengan bentuk studi kasus. Pengumpulan data dilakukan dengan menggunakan teknik wawancara, dokumentasi, dan observasi. Analisis data mengunakan metode analisis Miles dan Huberman, dengan melalui tiga prosedur yaitu reduksi data, penyajian data dan menarik kesimpulan/verifikasi. Sedangkan keabsahan menggunakan teknik berdasarkan atas kriteria derajat kepercayaan, keteralihan, ketergantungan, dan kepastian suatu data. Tuntutan menghadapi  implementasi Otonomi Daerah mengandung arti pentingnya Pemerintah Daerah memperhatikan kemampuan “self suporting” dalam bidang keuangan. Sumber pendapatan daerah tidak hanya di peroleh dari Pendapatan Asli Daerah, tetapi juga berupa pemberian bagi hasil dari penerimaan Pemerintah Pusat. Diantara sumber penerimaan tersebut adalah Pajak Bumi dan Bangunan. Dalam Undang-undang Nomor 25 Tahun 1999 Tentang perimbangan keuangan antara Pemerintah Pusat  dan Daerah, diantaranya dijelaskan bahwa sumber penerimaan daerah dalam penyelenggaraan desentralisasi berasal dari dana perimbangan penerimaan Pajak Bumi dan Bangunan disamping pemberian Dana Alokasi Umum dan Alokasi Khusus. Langkah Implementasi dari pelaksanan pemungutan Pajak Bumi dan Bangunan tersebut dilakukan Departemen Keuangan melalui Kantor Pelayanan Pajak Bumi dan Bangunan, sedang Pemerintah daerah menerima pelimpahan penagihan pada Sektor Perkotaan dan Sektor Pedesaan. Meskipun telah ada pelimpahan kewenangan kepada daerah, akan tetapi pelimpahan kewenangan tersebut terbatas pada mekanisme penagihan saja, sedang implementor yang menyangkut masalah administrasi masih berada pada Kantor Pelayan Pajak Bumi dan Bangunan. Kondisi demikian ini ditambah dengan kurangnya koordinasi antara unit organisasi pelaksana menyebabkan setiap tahun terjadi tunggakan. Sebagai sandaran teoritik utama  untuk mendiskripsikan serta menganalisis hambatan-hambatan implementasi kebijakan publik (dalam hal ini pemungutan

  14. TRANSFORMASI ORGANISASIONAL DAN MSDM: HAMBATAN DAN IMPLIKASINYA PADA REKRUTMEN DAN SELEKSI

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    Licen Indahwati Darsono

    2002-01-01

    Full Text Available Rapid change of environment is an external force that causes the organization to transform. Fundamentally, the main purpose of the transformation is to change the organizational structure to be more flexible and competitive with fewer hierarchial levels, managers, and employees. The transformation needs to be radical, causing resistance from the organization's members. Their resistance can cause the transformation to fail, therefore organization must find ways to lessen this resistance. First, organization must learn about the diversity of its members' cultures and values. Second, organization must build its own organizational culture which can support the success of the transformation, by communicating it with the members of the organization. To support organizational culture building efforts, it needs changes in human resources practices, especially recruitment and selection. Abstract in Bahasa Indonesia : Perubahan yang cepat dalam lingkungan merupakan kekuatan eksternal yang mengakibatkan transformasi dalam sebuah organisasi. Pada dasarnya, tujuan utama dari transformasi tersebut adalah merubah struktur organisasi agar menjadi lebih fleksibel dan mampu bersaing, dengan tingkat structural yang sedikit, serta jumlah manajer dan karyawan yang lebih kecil. Transformasi tersebut harus menyeluruh, dan hal ini dapat menyebabkan resistensi dari para anggota organisasi yang memperhambat perubahan tersebut. Resistensi itu bisa menyebabkan perubahan tersebut batal, oleh karena itu organisasi harus mencari jalan untuk mengurangi hambatan-hambatan tersebut. Pertama, organisasi harus belajar keanekaragaman dari budaya dan nilai anggotanya. Kedua, organisasi harus mengembangkan budaya organisasi sendiri melalui komunikasi yang baik dengan anggotanya. Untuk mendukung usaha mengembangkan budaya organisasi, harus ada perubaban pada kebijakan sumber daya manusia, terutama dalam rekrutmen dan seleksi karyawan. Kata kunci: transformasi, resistensi, budaya

  15. Tratamento cirúrgico da laringomalácia grave: estudo retrospectivo de 11 casos

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    José Antonio Pinto

    2013-10-01

    Full Text Available A laringomalácia é a anomalia congênita da laringe mais frequente, sendo responsável por cerca de 60% a 75% dos casos de estridor congênito. Apesar de seu curso benigno e autolimitado, 10% dos casos necessitam de intervenção. Atualmente, as supraglotoplastias são consideradas o tratamento padrão da laringomalácia grave. OBJETIVO: Descrever a experiência adquirida pelos autores no tratamento cirúrgico dos pacientes com laringomalácia grave. Metodologia: Estudo retrospectivo. MÉTODO: Os prontuários de 11 casos consecutivos de laringomalácia grave, submetidos ao tratamento cirúrgico entre 2003 e 2012, foram analisados quanto à idade, gênero, sintomas, doenças associadas, técnica cirúrgica adotada, tempo de extubação, complicações cirúrgicas, tempo de internação e evolução clínica. RESULTADOS: Dos 11 casos de laringomalácia grave, seis pacientes (54,5% foram operados com o uso do laser de CO2 e em cinco pacientes (45,5% foram realizadas a técnica a frio. Apenas um paciente (9,1% necessitou reabordagem cirúrgica. Não foram observados casos de complicações cirúrgicas. Todos os pacientes apresentaram melhora clínica importante. CONCLUSÃO: A supraglotoplastia mostrou-se um procedimento eficaz e seguro no tratamento da laringomalácia grave.

  16. The thickness of the retrobulbar portion of the optic nerve in Graves ophthalmopathy measured by ultrasound

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    Stefanović Ivan

    2009-01-01

    Full Text Available Introduction. The clinical diagnostic of Graves ophthalmopathy is based on the association of ocular signs and the disease of the thyroid gland. The evolution of the disease involves the development of eye globe protrusion, extraocular muscle thickening pressuring the optic nerve, which can result in its thickness. Objective. The aim of the paper is to find whether the retrobulbar optic nerve thickened and if there was a correlation between its possible thickening and the thickness of the muscles in Graves ophthalmopathy. We also wished to test the theory of compressive aetiology of such thickening using a 30-degree test. Methods. We examined 28 patients with Graves ophthalmopathy. The thickness of the retrobulbar optic nerve was measured by ultrasound on a B-scan using the Schraeder's method and by the largest thickness of the internal muscle. Results. The thickness of the retrobulbar portion of the optic nerve in the 52 analyzed eyes with signs of the disease ranged between 3.24 mm to 6.30 mm, with median of 5.13 mm, indicating that the majority of the patients had optic nerve thickening rating at this value. Forty-eight eyes had a marked retrobulbar optic nerve thickening, with the thickening over 4 mm, while in 4 eyes with signs of Graves ophthalmopathy the thickness of the optic nerve was within normal limits. We detected that 92.3% of the patients with muscular thickening also had a directly proportional thickening of the retrobulbar optic nerve. By using the 30-degree test we confirmed the diagnosis of compressive neuropathy. Conclusion. Patients with Graves ophthalmopathy and thickened muscles, also have a thickening of the retrobulbar optic nerve; the rate of the thickness directly depends on the degree of the muscular thickness. The word is of compressive neuropathy, i.e. the thickness of the optic nerve is the result of subarachnoid fluid stasis caused by the compression on the optic nerve.

  17. VAKSIN DENGUE DAN PERKEMBANGANNYA SAAT INI DAN DI MASA MENDATANG

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    Triwibowo Ambar Garjito

    2012-09-01

    Full Text Available Dengue virus merupakan salah satu virus anggota dari famili Flaviviridae yang sejak tahun 1956 telah dikenal dapat menimbulkan demam dengue maupun demam berdarah dengue (DBD. Penyakit yang ditularkan oleh nyamuk Aedes aegypti ini diperkirakan telah menjangkiti pada selatar 50-100 juta manusia dengan 500.000 kasus di antaranya dalam manifestasi yang ganas yang dikenal sebagai dengue haemorrhagic fever dan dengue shock syndrome dan 25.000 di antaranya berakibat fatal (meninggal. Saat ini pengembangan vaksin merupakan salah satu solusi yang diharapkan dapat menekan penyebaran penyakit tersebut. E (envelope merupakan salah satu bagian dari protein struktural virus yang sangat penting dalam pengembangan vaksin, yaitu sebagai badan yang memproduksi antibodi netralisasi untuk protein. Non-struktural protein l juga telah diketahui sebagai salah satu komponen penting dalam pengembangan vaksin oleh karena kemampuannya untuk dapat diekspresi pada permukaan sel yang diinfeksi yang dapat menjadi target untuk immune cytolisis. Ada dua pendekatan yang digunakan dalam memproduksi suatu vaksin dengue, yaitu: a. Vaksin hidup yang telah dilemahkan (live attenuated vaccine: b. Vaksin hasil rekayasa (engineered vaccine. Penelitian terhadap vaksin DENV baik rekombinan maupun non-rekombinan yang didasarkan pada uji virus telah dilakukan secara terus-menerus baik pada monyet dan manusia. Sampai saat ini telah dikembangkan sejumlah kandidat vaksin DENV yang berdasar pada tetravalent virus dengue, yaitu a. vaksin konvensional, b. vaksin dengue rekombinan berdasar pada flavivirus, c. vaksin intertypic chimeric, d. vaksin chimerivac, e. vaksin dengue rekombinan menggunakan vector non-ftavivirus dan f. vector adenovirus. Namun demikian, sampai sekarang belum ada vaksin yang siap digunakan untuk menangkal infeksi ke empat serotype virus dengue, sehingga masih diharapkan untuk pengembangan virus lebih lanjut.   Kata kunci: Aedes aegypti, dengue virus, vaksin dengue.

  18. Muhammad sebagai pemimpin agama dan negara periode Makkah dan Madinah

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    Ummu Zakiyah Maulidah

    2014-07-01

    Full Text Available Muhammad was born in Mecca between AD 570 and 580 in the Banu Hashims,a reputable family of Quraysh. In Mecca, Muhammad is portrayed as a privatecitizen, as he had to limit himself and adapt his behavior to face the situationduring jahiliyyah era. While, in Medina he governed the community and guidedthem in religious life. His arrival in Medina has significant contribution towardhis role as political leader. His power in this city had protected himself and hisfollowers from violent opposition of the Quraysh. The doctrines he employedin politics were inseparable from the religious values rooted from the Quran.Through his innovation and skillful diplomacy, he had converted the peopleof Mecca and Medina into brighter Arab civilization. Such a positive changereflected his monumental accomplishment for the people.Muhammad lahir di kota Makkah antara tahun 570 sampai 580 Masehi dikeluarga Bani Hasyim, suku Quraisy terkemuka di Arab. Di kota Makkah,Muhammad dianggap sebagai masyarakat biasa, sebab ia harus membatasidirinya dan menyesuaikan prilakunya dalam menghadapi keadaan yangterjadi pada zaman jahiliyyah. Sedangkan di Madinah, ia dianggap sebagaipemimpin masyarakat dan menjadi pembimbing umat dalam hidup beragama.Kedatangannya di Madinah juga memberikan konstribusi besar pada perannyasebagai pemimpin politik. Kekuasaan di kota ini sangat membantu dirinya danpara pengikutnya dari kerasnya kelompok oposisi Quraisy. Doktin-doktrin yangdigunakan Muhammad dalam dunia politik juga tidak lepas dari nilai-nilaiagama yang bersumber dari al Quran. Dengan kreatifitas dan inovasinya dalammemimpin, Muhammad mampu mengarahkan masyarakat Makkah dan Madinah menuju kebangkitan peradaban bangsa Arab yang lebih cemerlang.Kondisi yang semakin membaik tersebut, tidak lain merupakan sebuah karyadan jasa monumental yang telah diukir oleh Muhammad untuk umatnya.

  19. [Drivers of advanced age in traffic accidents].

    Science.gov (United States)

    Bilban, Marjan

    2002-12-01

    The elderly are vulnerable and potentially unpredictable active participants in traffic who deserve special attention. Longer life expectancy entails a greater number of senior drivers, that is, persons with various health problems and difficulties accompanying old age. At the turn of the millennium, the share of population aged 65 or more in Slovenia was around 13%, and in 25 years it will be near as much as 19%. The share of drivers from this age group was 28% a year ago, and it is expected to reach about 54%. Numerous studies have shown that there are many differences in driving attitude between the young and the elderly. The young are by large active victims, and their main offense and cause of accident is speeding, while the elderly are more passive and their main offense is ignoring and enforcing the right of way. This paper focuses on the differences in the occurrence and type of injuries between the young and the elderly drivers, based on an analysis of all road accidents in Slovenia in the period between 1998-2000. Older people (over 65) caused only 4.7% of all road accidents (16.7% of all accidents involving pedestrians, 11.5% of all involving cyclists, 2.7% involving motorcyclists and 5% of all accidents involving car drivers). Of all accidents, 89.3% were without injuries, and the fatal outcome was registered in 0.4% accidents. Among the elderly (65-74 years of age), however, this share was 1%, and rising to 2.7% with the age 75 and above. By calculating the weight index, which discriminates between minor and severe injuries, and the fatal outcome, it was established that age groups 65-74 and > or = 75 cause three and five times greater damage, respectively than age groups from 18 to 54 years. With years, psychophysical changes lead to a drop in driving ability, which in turn increases the risk of road accidents. It is true that elderly people cause less traffic accidents (and also drive less) than the young, but when they are involved in an accident

  20. KONTEKS DAN KONSTRUKSI SOSIAL MENGENAI KEMATIAN ELEKTIF ( EUTHANASIA ∗

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    Helly Prajitno Soetjipto

    2015-09-01

    konteks sosial dan konstruksi sosial kematian. Euthanasia didiskusikan di dalam suatu kerangka pikir yang mencoba memberi perhatian kepada hal-hal yang kontekstual dan interpretatif fenomena sosial suatu proses kematian dan kejadian kematian