WorldWideScience

Sample records for accidental localised irradiations

  1. Localised acute irradiations. radiological bases of diagnosis and treatment; Irradiations aigues localisees. Bases radiobiologiques du diagnostic et du traitement

    Energy Technology Data Exchange (ETDEWEB)

    Daburon, F. [CEA, 75 - Paris (France)

    1997-12-31

    The prognosis, the diagnosis and the treatment of localized acute irradiations coming from a therapeutic overdose is still now a difficult problem. The skin structure and this one of subjacent tissues have several different cellular components with a very different response to irradiation; The analyzed data come from experimental irradiations, clinical examinations after accidental overexposure and the observations that lead to therapeutic protocols of irradiations. All these results have given the preference to the description of cutaneous lesions. Skin has often been used as normal tissue. The results for subjacent tissues are more fragmentary whereas it is the attack of these tissues that will condition the prognosis and the ability to heal the superficial lesions. (N.C.)

  2. Localised vibrational mode spectroscopy studies of self-interstitial clusters in neutron irradiated silicon

    Energy Technology Data Exchange (ETDEWEB)

    Londos, C. A.; Antonaras, G. [University of Athens, Solid State Physics Section, Panepistimiopolis Zografos, Athens 157 84 (Greece); Chroneos, A. [Materials Engineering, The Open University, Milton Keynes MK7 6AA (United Kingdom); Department of Materials, Imperial College, London SW7 2AZ (United Kingdom)

    2013-07-28

    The evolution of self-interstitial clusters in silicon (Si), produced by fast neutron irradiation of silicon crystals followed by anneals up to 750 °C, is investigated using localised vibrational mode spectroscopy. A band at 582 cm{sup −1} appears after irradiation and is stable up to 550 °C was attributed to small self-interstitial clusters (I{sub n}, n ≤ 4), with the most probable candidate the I{sub 4} structure. Two bands at 713 and 758 cm{sup −1} arising in the spectra upon annealing of the 582 cm{sup −1} band and surviving up to ∼750 °C were correlated with larger interstitial clusters (I{sub n}, 5 ≤ n ≤ 8), with the most probable candidate the I{sub 8} structure or/and with chainlike defects which are precursors of the (311) extended defects. The results illustrate the presence of different interstitial clusters I{sub n}, at the various temperature intervals of the material, in the course of an isochronal anneal sequence. As the annealing temperature increases, they evolve from first-order structures with a small number of self-interstitials (I{sub n}, n ≤ 4) for the temperatures 50 < T < 550 °C, to second order structures (I{sub n}, 5 ≤ n ≤ 8) with a larger number of interstitials, for the temperatures 550 < T < 750 °C.

  3. Indications of hematopoietic stem cell transplantations and therapeutic strategies of accidental irradiations; Indications des greffes de cellules souches hematopoietiques et strategies therapeutiques des irradiations accidentelles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Produced by a group of experts, this document first discusses the issue of accidental irradiations in terms of medical management. They notably outline the peculiar characteristics of these irradiations with respect to therapeutic irradiations. They agreed on general principles regarding casualty sorting criteria and process, and their medical treatment (systematic hematopoiesis stimulation, allogeneic transplantation of hematopoietic stem cells). They discuss some practical aspects of these issues: casualty sorting within a therapeutic perspective (actions to be performed within 48 hours), therapeutic strategies (support therapy, use of cytokines, and therapy by hematopoietic stem cell transplant). They state a set of recommendations regarding the taking into care and diagnosis, therapeutic strategies, research perspectives, and teaching

  4. Localizing by autoradiography at -195 deg radioactive areas in rats exposed to a high flux of thermal neutrons, importance of phosphorus 32 in consecutive internal irradiation; Localisation par autoradiographie a -195 deg des zones radioactives chez le rat expose a un haut flux de neutrons thermiques, importance du phosphore 32 dans l'irradiation interne consecutive

    Energy Technology Data Exchange (ETDEWEB)

    Chanteur, J.; Pellerin, P. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    Rats weighing 25 g were exposed for 5 mn to a flux of 6.10{sup 12} thermal neutrons/cm{sup 2}/s. Anatomical autoradiography at -195 deg. C has enabled the radioactive organs to be easily localised, to follow in course of time the decrease of radioactivity, and from it to deduce the probable nature of the numerous emitters in question. In particular, the phosphorus 32 has thus appeared to be one of those responsible for internal irradiation, general, on the one hand, by activating cellular phosphorus, local, on the other, by activating bony phosphates. Owing to this, an accidental irradiation by neutrons might have consequences that are both somatic (elective irradiation of the bone marrow) and genetic (activation of nucleic acids). The gamma spectrometry has confirmed the nature of certain other emitters. (author) [French] Des rats de 25 g ont ete exposes pendant 5 mn a un flux de 6.10{sup 12} neutrons thermiques/cm{sup 2}/s. L'autoradiographie anatomique a -195 deg. C a permis de localiser facilement les organes radioactifs, de suivre dans le temps la decroissance de la radioactivite, et d'en deduire la nature probable des nombreux emetteurs en cause. En particulier, le phosphore 32 est ainsi apparu comme l'un des responsables de l'irradiation interne, d'une part generale par activation du phosphore cellulaire, d'autre part locale par activation des phosphates osseux. Une irradiations accidentelle par neutrons aurait, de ce fait, des consequences a la fois somatiques (irradiation elective de la moelle osseuse) et genetiques (activation des acides nucleiques). La spectrometrie gamma a confirme la nature de certains autres emetteurs. (auteur)

  5. Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells; Approches therapeutiques du syndrome hematopoietique apres irradiation globale accidentelle grave. Interet de l`expansion ex vivo des cellules hematopoietiques

    Energy Technology Data Exchange (ETDEWEB)

    Thierry, D.

    1994-12-31

    Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too.

  6. Ex vivo expansion of haematopoietic cells in the treatment of accidental irradiation-induced aplasia. Feasibility Studies

    Energy Technology Data Exchange (ETDEWEB)

    Thierry, D.; Bertho, J.M.; Chapel, A.; Gourmelon, P. [Institut de Protection et de Surete Nucleaire, Fountenay-aux-Roses (France)

    2000-05-01

    haematopoietic cells for the treatment of accidental irradiation-induced aplasia. (author)

  7. Long-term follow-up after accidental gamma irradiation from a {sup 192}Ir source in Bangladesh

    Energy Technology Data Exchange (ETDEWEB)

    Mollah, A.S.; Begum, A.; Begum, R. [Bangladesh Atomic Energy Commission, Dhaka (Bangladesh)

    2006-07-01

    A industrial radiographer was accidentally over -exposed to high dose of ionizing radiation from an {sup 192}Ir source pellet during radiograph y of weld-joints in gas pipe-lines on June 10, 1985 in Bangladesh. The source, housed in a portable exposure assembly, had an activity of about 1850 GBq. A guide -tube was used to control the transfer of the source from safe storage position to the exposure position and vice versa. For radiography, the ti p of the guide tube was to be fixed to the weld -joint while the source was cranked to the exposure position. Following the elapse of the preset exposure time the source had to be cranked back to the safe stor age position. This procedure was to be repeated for each radiographic exposure. Symptoms of high radiation exposure occurred immediately after the accident and skin erythema developed leading to progressive tissue deteriorations. Biological effects such as mild vomiting, malaise, nausea and diarrhea occurred within a short period after the accident. Skin erythema, swelling and tenderness of the palmar surfaces and the tips of the thumbs, index fingers and middle fingers of the both hands accompanied by severe pain and inflammation developed within 7 days of the mishap. The inflammatory changes characterized by redness and bullae spread over the affected fingers with severe pain and agony within a few days. The finger -tips developed abscesses with enormous pus formation and the affected finger nails fell off. He also developed toothache. At this stage a medical practitioner made some surgical dressings and prescribed antibiotics. During the first six months the most serious health disorder was local necroses of the skin and the deep layers of the palmar side of the affected fingers with sharply delineated injuries. The clinical findings were consistent with those reported elsewhere under similar accident conditions. The consequences of this over-exposure are being followed up to assess the long-term effects of

  8. Accidental hypothermia

    Directory of Open Access Journals (Sweden)

    Ivo Casagranda

    2006-02-01

    Full Text Available Hypothermia is defined as an unintentional decrease of core body temperature below 35 °C. In this article we discuss pathophysiology, clinical aspects and treatment of hypothermic patients. The most important treatment of hypothermia is the identification of the most appropriate method of rewarming. We report a case of cardiac arrest secondary to severe accidental hypothermia, that occured in a young man, do to prolonged exposure to low temperature in river water, successfully treated with extracorporeal blood warming.

  9. Accidental Innovation

    DEFF Research Database (Denmark)

    Austin, Robert D.; Devin, Lee; Sullivan, Erin E.

    2012-01-01

    Historical accounts of human achievement suggest that accidents can play an important role in innovation. In this paper, we seek to contribute to an understanding of how digital systems might support valuable unpredictability in innovation processes by examining how innovators who obtain value from...... they incorporate accidents into their deliberate processes and arranged surroundings. By comparing makers working in varied conditions, we identify specific factors (e.g., technologies, characteristics of technologies) that appear to support accidental innovation. We show that makers in certain specified...... conditions not only remain open to accident but also intentionally design their processes and surroundings to invite and exploit valuable accidents. Based on these findings, we offer advice for the design of digital systems to support innovation processes that can access valuable unpredictability....

  10. Localisation Microscopy of Breast Epithelial ErbB-2 Receptors and Gap Junctions: Trafficking after γ-Irradiation, Neuregulin-1β, and Trastuzumab Application

    Science.gov (United States)

    Pilarczyk, Götz; Nesnidal, Ines; Gunkel, Manuel; Bach, Margund; Bestvater, Felix; Hausmann, Michael

    2017-01-01

    In cancer, vulnerable breast epithelium malignance tendency correlates with number and activation of ErbB receptor tyrosine kinases. In the presented work, we observe ErbB receptors activated by irradiation-induced DNA injury or neuregulin-1β application, or alternatively, attenuated by a therapeutic antibody using high resolution fluorescence localization microscopy. The gap junction turnover coinciding with ErbB receptor activation and co-transport is simultaneously recorded. DNA injury caused by 4 Gray of 6 MeV photon γ-irradiation or alternatively neuregulin-1β application mobilized ErbB receptors in a nucleograde fashion—a process attenuated by trastuzumab antibody application. This was accompanied by increased receptor density, indicating packing into transport units. Factors mobilizing ErbB receptors also mobilized plasma membrane resident gap junction channels. The time course of ErbB receptor activation and gap junction mobilization recapitulates the time course of non-homologous end-joining DNA repair. We explain our findings under terms of DNA injury-induced membrane receptor tyrosine kinase activation and retrograde trafficking. In addition, we interpret the phenomenon of retrograde co-trafficking of gap junction connexons stimulated by ErbB receptor activation. PMID:28208769

  11. Accidentes laborales viales

    OpenAIRE

    Corzo Suárez, Susana

    2012-01-01

    El objetivo principal de este proyecto es dar a conocer la problemática de la aplicación del de la ley 31/1995, de 8 de noviembre, de Prevención de Riesgos Laborales, en la evaluación y prevención de los riesgos de los accidentes laborales viales. Para poder llegar a este objetivo se han utilizado diversas vías de estudio: Intentar aclarar qué son accidentes de tráfico y qué son accidentes laborales viales; Cuáles son los diferentes tipos de accidentes laborales viales y sus principales ca...

  12. Study and simulation of irradiated zirconium alloys fracture under type RIA accidental loading conditions; Comprehension et modelisation de la rupture d'alliages de zirconium irradies en conditions accidentelles de type RIA

    Energy Technology Data Exchange (ETDEWEB)

    Le Saux, M. [CEA Saclay, Dept. des Materiaux pour le Nucleaire (DEN/DANS/DMN/SEMI), 91 - Gif-sur-Yvette (France)

    2008-07-01

    The thesis aims to study and simulate the mechanical behavior under Reactivity Initiated Accident loading conditions, of the Zircaloy 4 fuel claddings, irradiated or not. It also aims to characterize and simulate the behavior and the fracture under RIA loading conditions of hydrided Zircaloy 4 non irradiated. This study proposes an experimental approach and a simulation. (A.L.B.)

  13. Radiative accidental matter

    CERN Document Server

    Sierra, D Aristizabal; Wegman, D

    2016-01-01

    Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, big bang nucleosynthesis and electroweak perturbativity, finding that the latter places the most stringent constraints on the mass spectra. These results allow the identification of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that $\\mu\\to e \\gamma$ has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below $10^6\\,$ GeV, a value (natur...

  14. Localisation in Quantum Field Theory

    CERN Document Server

    Balachandran, A P

    2016-01-01

    In nonrelativistic quantum mechanics , Born's principle of localisation is as follows: For a single particle, if a wave function $\\psi_K$ vanishes outside a spatial region $K$, it is said to be localised in $K$. In particular if a spatial region $K'$ is disjoint from $K$, a wave function $\\psi_{K'}$ localised in $K'$ is orthogonal to $\\psi_K$. Such a principle of localisation does not exist compatibly with relativity and causality in quantum field theory (Newton and Wigner) or interacting point particles (Currie,Jordan and Sudarshan).It is replaced by symplectic localisation of observables as shown by Brunetti, Guido and Longo, Schroer and others. This localisation gives a simple derivation of the spin-statistics theorem and the Unruh effect, and shows how to construct quantum fields for anyons and for massless particles with `continuous' spin. This review outlines the basic principles underlying symplectic localisation and shows or mentions its deep implications. In particular, it has the potential to affect...

  15. Flavour from accidental symmetries

    Energy Technology Data Exchange (ETDEWEB)

    Ferretti, Luca [SISSA/ISAS and INFN, I-34013 Trieste (Italy); King, Stephen F. [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom); Romanino, Andrea [SISSA/ISAS and INFN, I-34013 Trieste (Italy)

    2006-11-15

    We consider a new approach to fermion masses and mixings in which no special 'horizontal' dynamics is invoked to account for the hierarchical pattern of charged fermion masses and for the peculiar features of neutrino masses. The hierarchy follows from the vertical, family-independent structure of the model, in particular from the breaking pattern of the Pati-Salam group. The lightness of the first two fermion families can be related to two family symmetries emerging in this context as accidental symmetries.

  16. Non destructive localization by gamma tomography of fission products emission in a fuel pencil area after an accidental sequence; Localisation non destructive par tomographie gamma d`emission des produits de fission dans une section de crayon combustible ayant subi une sequence accidentelle

    Energy Technology Data Exchange (ETDEWEB)

    Ducros, G.; Confort, E.; Drevon, P.

    1994-12-31

    The transverse gamma spectrometry of an irradiated fuel pencil, associated to a tomography method of gamma emitters reconstruction in a straight section of the pencil, is a non destructive technique which proves efficient when there are enough projections. For a little irradiated fuel, four to six projections equally distributed on 180 degrees and associated to an activity repartition initial model with symmetry of revolution are generally sufficient. For a very damaged fuel, it is necessary to practice eighteen projections every ten degrees; the initial repartition model is no more a noticeable parameter. Applied to the VERCORS safety programme, it allows to know the fuel behavior in situation of serious accident and the radial migrations of fission products. The localization of gamma emitters fission products brings informations supplementary to others optical techniques (ceramographies), or chemical techniques (micro-probe). Then, by its non destructive aspect, it can be in certain cases, unavoidable in front of usual destructive techniques. (N.C.). 4 refs.

  17. Probabilistic localisation in repetitive environments

    NARCIS (Netherlands)

    Vroegindeweij, Bastiaan A.; IJsselmuiden, Joris; Henten, van Eldert J.

    2016-01-01

    One of the problems in loose housing systems for laying hens is the laying of eggs on the floor, which need to be collected manually. In previous work, PoultryBot was presented to assist in this and other tasks. Here, probabilistic localisation with a particle filter is evaluated for use inside p

  18. Accidental dapsone poisoning in children.

    Science.gov (United States)

    Nair, P M; Philip, E

    1984-12-01

    Accidental poisoning in children shows a trend towards poisoning with various newer drugs and chemicals used in the household. Sixty-one cases of accidental poisoning in children were seen in Sree Avittam Thirunal Hospital, (S.A.T.H.), Trivandrum, South India during the year 1982, constituting 0.61% of the total pediatric admissions. Dapsone poisoning constituted 9.8% of the total accidental poisonings, emphasising the need for safe storage of drugs out of the reach of young children. Dapsone poisoning with resultant methaemoglobinaemia responded well to intravenous ascorbic acid and other supportive measures.

  19. The accidental technology trainer: a guide for libraries

    National Research Council Canada - National Science Library

    Gerding, Stephanie

    2007-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xvii Chapter 1: Being an Accidental Technology Trainer . . . . . . . . . . . . . . . . . . 1 What Is an Accidental Technology Trainer...

  20. Allegheny County Fatal Accidental Overdoses

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Fatal accidental overdose incidents in Allegheny County, denoting age, gender, race, drugs present, zip code of incident and zip code of residence. Zip code of...

  1. Part of the oxidative stress in the development of radio-induced cell effects at cutaneous level: application to accidental localised irradiations; Role du stress oxydatif dans le developpement des effets cellulaires radio-induits au niveau cutane: application aux irradiations localisees accidentelles

    Energy Technology Data Exchange (ETDEWEB)

    Carine, Laurent

    2005-10-15

    The objective of our study was to answer to the following questions: does the initial radio-induced oxidative stress lead to the accumulation of DNA damages in the low renewal cells (fibroblasts, endothelial cells) that could be responsible of delayed effects; does it exist delayed oxidative phenomena and era they implied in the delayed effects arising; does it exist a phenomenon of premature senescence; does it exist a premature senescence phenomenon that could lead to an accumulation of damages before the cell death; what are the action mechanisms of the association pentoxifylline/{alpha}-tocopherol. (N.C.)

  2. Localised processing power for CAMAC systems

    CERN Document Server

    Iselin, F Christoph; Ponting, P

    1975-01-01

    Implantation of localised processors in a system can often enhance the efficacy of CAMAC. Some typical localised processors are presented and an indication given of how appropriate positioning within a CAMAC system can minimize the effect of some of the restrictive characteristics of source data and system configuration. (6 refs).

  3. Multimodal Localisation: Analysis, Algorithms and Experimental Evaluation

    NARCIS (Netherlands)

    Kavitha Muthukrishnan, K.

    2009-01-01

    The term localisation is derived from the word locale, which traditionally means a small area or vicinity. In ancient days, localisation meant navigation -- an art of finding the way from one place to another. Tremendous advancement in the science of navigation dates back to the sixteenth century,

  4. Multimodal localisation : analysis, algorithms and experimental evaluation

    NARCIS (Netherlands)

    Muthukrishnan, Kavitha

    2009-01-01

    The term localisation is derived from the word locale, which traditionally means a small area or vicinity. In ancient days, localisation meant navigation -- an art of finding the way from one place to another. Tremendous advancement in the science of navigation dates back to the sixteenth century, w

  5. Multimodal Localisation: Analysis, Algorithms and Experimental Evaluation

    NARCIS (Netherlands)

    Kavitha Muthukrishnan, K.

    2009-01-01

    The term localisation is derived from the word locale, which traditionally means a small area or vicinity. In ancient days, localisation meant navigation -- an art of finding the way from one place to another. Tremendous advancement in the science of navigation dates back to the sixteenth century, w

  6. Accidente de Trabajo y Recargo

    OpenAIRE

    Pérez Alonso, María Antonia

    2015-01-01

    En la actualidad existen diferentes formas de Accidente de Trabajo. En el presente trabajo se da a conocer las distintas formas y la doctrina de los tribunales. Se aborda el recargo de prestaciones de Seguridad Social y el deber del empresario en cumplir la normativa de Seguridad Social

  7. Desordre et phenomenes de localisation

    CERN Document Server

    Lacoin, Hubert

    2009-01-01

    Cette these est consacree a l' etude de differents modeles aleatoires de polymeres. On s'interesse en particulier a l'influence du desordre sur la localisation des trajectoires pour les modeles d'accrochage et pour les polymeres diriges en milieu aleatoire. En plus des modeles classiques dans Zd, nous abordons l' etude de modeles dit hierarchiques, construits sur une suite de reseaux auto-similaires, tres present dans la litterature physique. Les resultats que nous avons obtenus concernent principalement l' energie libre et le phenomene de surdiffusivite. En particulier, nous prouvons: (1) la pertinence du desordre a toute temperature dans pour le modele d' accrochage desordonne en dimension 1 + 1, (2) l' occurence d' un desordre tres fort a toute temperature en dimension 1 + 2 pour les polymeres diriges en milieu aleatoire. This thesis studies models of random directed polymers. We focus on the influence of disorder on localization of the trajectories for pinning model and directed polymers in random environ...

  8. Bounds on localisable information via semidefinite programming

    CERN Document Server

    Synak, B; Horodecki, M; Synak, Barbara; Horodecki, Karol; Horodecki, Michal

    2004-01-01

    We investigate so-called localisable information of bipartite states and a parallel notion of information deficit. Localisable information is defined as the amount of information that can be concentrated by means of classical communication and local operations where only maximally mixed states can be added for free. The information deficit is defined as difference between total information contents of the state and localisable information. We consider a larger class of operations: the so called PPT operations, which in addition preserve maximally mixed state (PPT-PMM operations). We formulate the related optimization problem as sedmidefnite program with suitable constraints. We then provide bound for fidelity of transition of a given state into product pure state on Hilbert space of dimension d. This allows to obtain general upper bound for localisable information (and also for information deficit). We calculated the bounds exactly for Werner states and isotropic states in any dimension. Surprisingly it turns...

  9. Visual localisation in patients with occipital infarction.

    OpenAIRE

    Ross Russell, R W; Bharucha, N

    1984-01-01

    Visually directed pointing has been examined in a group of patients with occipital lobe infarction and in an age-matched control group. The visual field ipsilateral to the infarct showed normal localisation; there was no evidence that right sided infarction produced a bilateral disturbance. In quadrantanopia the spared quadrant on the affected side showed abnormal localisation in a few patients but this was not consistently associated with right or left sided defects. The majority of patients...

  10. Multimodal Localisation: Analysis, Algorithms and Experimental Evaluation

    OpenAIRE

    Kavitha Muthukrishnan, K.

    2009-01-01

    The term localisation is derived from the word locale, which traditionally means a small area or vicinity. In ancient days, localisation meant navigation -- an art of finding the way from one place to another. Tremendous advancement in the science of navigation dates back to the sixteenth century, when instruments like compasses, sextants and the first ever clock to keep the time exactly were devised. Advancement in navigation brought ways and means to explore the world, be it for expansion o...

  11. A Relational Localisation Theory for Topological Algebras

    OpenAIRE

    2012-01-01

    In this thesis, we develop a relational localisation theory for topological algebras, i.e., a theory that studies local approximations of a topological algebra’s relational counterpart. In order to provide an appropriate framework for our considerations, we first introduce a general Galois theory between continuous functions and closed relations on an arbitrary topological space. Subsequently to this rather foundational discussion, we establish the desired localisation theory comprising the i...

  12. Accidental haloperidol poisoning in children

    Directory of Open Access Journals (Sweden)

    Mona P Gajre

    2012-01-01

    Full Text Available Haloperidol, a butyrophenone neuroleptic drug, is an antipsychotic used in the treatment of adult schizophrenia and mania. It is used in children with neurological disorders like chorea and developmental disorders such as hyperactivity. With the advent of newer selective neuroleptics use of haloperidol is now on decline. However, in adults it is still the preferred drug especially in resource challenged settings. Extrapyramidal reactions occur frequently with haloperidol predominantly as parkinsonian symptoms. There are few case reports of accidental haloperidol poisoning in children and this one of them.

  13. Mitigation of Lung Injury after Accidental Exposure to Radiation

    Science.gov (United States)

    Mahmood, J.; Jelveh, S.; Calveley, V.; Zaidi, A.; Doctrow, S. R.; Hill, R. P.

    2011-01-01

    There is a serious need to develop effective mitigators against accidental radiation exposures. In radiation accidents, many people may receive nonuniform whole-body or partial-body irradiation. The lung is one of the more radiosensitive organs, demonstrating pneumonitis and fibrosis that are believed to develop at least partially because of radiation-induced chronic inflammation. Here we addressed the crucial questions of how damage to the lung can be mitigated and whether the response is affected by irradiation to the rest of the body. We examined the widely used dietary supplement genistein given at two dietary levels (750 or 3750 mg/kg) to Fischer rats irradiated with 12 Gy to the lung or 8 Gy to the lung + 4 Gy to the whole body excluding the head and tail (whole torso). We found that genistein had promising mitigating effects on oxidative damage, pneumonitis and fibrosis even at late times (36 weeks) when drug treatment was initiated 1 week after irradiation and stopped at 28 weeks postirradiation. The higher dose of genistein showed no greater beneficial effect. Combined lung and whole-torso irradiation caused more lung-related severe morbidity resulting in euthanasia of the animals than lung irradiation alone. PMID:22013884

  14. Hematopoiesis stimulation test by interleukin 1{alpha} gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation; Essais de stimulation de l'hematopoiese par le transfert de gene de l'interleukine-1{alpha} chez le macaque cynomolgus: application a l'aplasie medullaire secondaire a une irradiation accidentelle

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, Th.

    2002-12-15

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  15. A Localised Corrosion Cell for Industrial Applications

    DEFF Research Database (Denmark)

    Andersen, A.; Hilbert, Lisbeth Rischel; Jansen, P.

    2003-01-01

    The LOCORR-CELL™ developed by FORCE TECHNOLOGY is an electrochemical cell for industrial applications estimating localised corrosion. The cell is constructed in a carbon steel casing for direct mounting into the system. It is based on an oxygen concentration element reflecting the interaction...... between the environment formed under a deposit or in a crevice. The essential feature of the method is that it reflects the influence of oxygen content, conductivity and temperature as well as the influence of corrosion inhibitors, MIC and other effects that have an effect on localised corrosion under...

  16. A Localised Corrosion Cell for Industrial Applications

    DEFF Research Database (Denmark)

    Andersen, A.; Hilbert, Lisbeth Rischel; Jansen, P.

    2003-01-01

    The LOCORR-CELL™ developed by FORCE TECHNOLOGY is an electrochemical cell for industrial applications estimating localised corrosion. The cell is constructed in a carbon steel casing for direct mounting into the system. It is based on an oxygen concentration element reflecting the interaction...... between the environment formed under a deposit or in a crevice. The essential feature of the method is that it reflects the influence of oxygen content, conductivity and temperature as well as the influence of corrosion inhibitors, MIC and other effects that have an effect on localised corrosion under...

  17. Application of biological dosimetry in accidental radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Nosal, M.; Batora, I.; Kolesar, D.; Stojkovic, J. (Komenskeho Univ., Bratislava (Czechoslovakia). Lekarska Fakulta); Gaal, P.; Sklovsky, A. (Krajska Hygienicka Stanica, Bratislava (Czechoslovakia)); Cizova, O. (Sexuologicka Ambulancia KUNZ, Bratislava (Czechoslovakia))

    1982-03-01

    The case is described of accidental irradiation of a male person with /sup 137/Cs of an activity of 24.71 GBq. The first estimate induced a reasonable suspicion that the absorbed dose could be very high and life-threatening. On the other hand the clinical picture, usual laboratory examinations, findings in the fluorescent blood count, the analysis of chromosomal count of lymphocytes in the peripheral blood, the spermiogram, and the negative post-irradiation porphyrinuria suggested that the absorbed dose could be much lower than the original estimate. The results of dosimetry obtained after the reconstruction of the accident by measuring on a phantom revealed that the actual dose was very close to that presumed from the results of biological dosimetry during the first days of examination of the patient.

  18. Accidental inflation in the landscape

    Energy Technology Data Exchange (ETDEWEB)

    Blanco-Pillado, Jose J.; Metallinos, Konstantinos [Institute of Cosmology, Department of Physics and Astronomy, Tufts University, Medford, MA (United States); Gomez-Reino, Marta, E-mail: jose@cosmos.phy.tufts.edu, E-mail: marta.gomez-reino.perez@cern.ch, E-mail: Konstantinos.Metallinos@tufts.edu [Department of Physics, University of Oviedo, Oviedo (Spain)

    2013-02-01

    We study some aspects of fine tuning in inflationary scenarios within string theory flux compactifications and, in particular, in models of accidental inflation. We investigate the possibility that the apparent fine-tuning of the low energy parameters of the theory needed to have inflation can be generically obtained by scanning the values of the fluxes over the landscape. Furthermore, we find that the existence of a landscape of eternal inflation in this model provides us with a natural theory of initial conditions for the inflationary period in our vacuum. We demonstrate how these two effects work in a small corner of the landscape associated with the complex structure of the Calabi-Yau manifold P{sup 4}{sub [1,1,1,6,9]} by numerically investigating the flux vacua of a reduced moduli space. This allows us to obtain the distribution of observable parameters for inflation in this mini-landscape directly from the fluxes.

  19. Accidental Inflation in the Landscape

    CERN Document Server

    Blanco-Pillado, Jose J; Metallinos, Konstantinos

    2012-01-01

    We study some aspects of fine tuning in inflationary scenarios within string theory flux compactifications and, in particular, in models of accidental inflation. We investigate the possibility that the apparent fine-tuning of the low energy parameters of the theory needed to have inflation can be generically obtained by scanning the values of the fluxes over the landscape. Furthermore, we find that the existence of a landscape of eternal inflation in this model provides us with a natural theory of initial conditions for the inflationary period in our vacuum. We demonstrate how these two effects work in a small corner of the landscape associated with the complex structure of the Calabi-Yau manifold P^4_[1,1,1,6,9] by numerically investigating the flux vacua of a reduced moduli space. This allows us to obtain the distribution of observable parameters for inflation in this mini-landscape directly from the fluxes.

  20. Domains involved in TAF15 subcellular localisation

    DEFF Research Database (Denmark)

    Marko, Marija; Vlassis, Arsenios; Guialis, Apostolia

    2012-01-01

    TAF15 (TBP associated factor 15) is a member of the highly conserved TET (also known as FET) protein family of RNA binding proteins (RBP), which comprises in addition FUS (fused in sarcoma, also known as TLS, translocated in liposarcoma) and EWS (Ewing sarcoma protein). The TET proteins are impli...... regulated in the HeLa and the neuronal HT22 cell lines and that TAF15 co-localised with a minor subset of RNA granules in the cytoplasm of HT22 cells, supporting a model whereupon TAF15 plays a role in RNA transport and/or local RNA translation....... to play important roles in the onset of specific tumours, certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). In this study we identified the domains of TAF15 responsible for its subcellular localisation in human (HeLa) cells and experimentally confirmed......, capable of being targeted to stress granules. We, moreover, showed that TAF15 cellular localisation depended on ongoing transcription and that independent domains of TAF15 engaged in nucleolar capping upon transcription inhibition. Finally, we demonstrated that TAF15 localisation was differentially...

  1. Detection and localisation of magnetic objects

    NARCIS (Netherlands)

    Barrell, Y.; Naus, H.W.L.

    2007-01-01

    Detection and localisation of hidden magnetic objects is studied. The concomitant disturbance of the earth magnetic field is exploited. Magnetic fields and or gradients are measured with a number of sensors. Two point models for magnetic fields are selected for the analysis: the magnetic dipole and

  2. Search and localisation of CERN buildings

    CERN Multimedia

    TS/FM - Patrimony and Site Information Section

    2005-01-01

    A new, updated version of the web application allowing search and localisation of CERN buildings has been available since 20 May 2005. You can now find a specific building, road, car-park and other information regarding the CERN sites. For comments or enquiries please contact SIG.Support@cern.ch TS/FM - Patrimony and Site Information Section (ISP)

  3. Primary localised cutaneous amyloidosis - a systematic review

    DEFF Research Database (Denmark)

    Kaltoft, Britta; Schmidt, Grethe; Lauritzen, Anne Falensteen;

    2013-01-01

    Amyloidosis is defined as extracellular deposits of heterogenic, misfolded proteins, amyloid fibrils, in various tissues. The aim of our study was to review the literature and to evaluate the risk of developing systemic amyloidosis (SA) and the risk of local recurrence of primary localised...... cutaneous amyloidosis (PLCA). The method of treatment was compared to the risk of local recurrence....

  4. Underground navigation and localisation using RFID tags

    CSIR Research Space (South Africa)

    James, S

    2012-10-01

    Full Text Available One of the major issues in the field of mobile robotics is localisation and navigation in an unknown environment. These tasks become even more challenging in an underground environment where no GPS signals or stationary landmark towers are available...

  5. Radiotherapy in the treatment of localised non-Hogkin's lymphoma (report no. 16)

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, D.L. (Middlesex Hospital, London (UK))

    1981-09-01

    This report describes the experience of the British National Lymphoma Investigation (BNLI) in the treatment of localised (Stages I, II) non-Hodgkin's lymphoma (NHL). About a third of all patients with NHL presenting to collaborators in the BNLI were considered after investigation to have localised disease. This relatively large number suggests that some cases may have been understaged. Patients with Grade I disease were treated with either local irradiation or with local irradiation followed by chlorambucil. Survival rates in the two groups were essentially similar and it appeared that radiotherapy alone provided equally effective treatment. Patients with Grade 2 lymphomas were treated either with local irradiation or with local irradiation followed by COP. Primary nodal disease was not obviously affected by the addition of chemotherapy. Extranodal disease arising in the gut below the diaphragm appeared to be adversely affected by the irradiation which was of necessity spread over several weeks, delaying the use of chemotherapy. Extranodal disease arising in the head and neck region is controlled in about 80% of patients and the routine use of prophylactic combination chemotherapy confers no benefit to the patient.

  6. Accidental methanol ingestion: Case report

    Directory of Open Access Journals (Sweden)

    Bakker Jan

    2010-02-01

    Full Text Available Abstract Background The incidence of methanol (CH3OH intoxication differs enormously from country to country. Methanol intoxication is extremely rare in the Dutch population. Even a low dose can already be potentially lethal. Patients are conventionally treated with hemodialysis. Therefore we'd like to present a report of a foreign sailor in Rotterdam who accidentally caused himself severe methanol intoxication, with a maximum measured concentration of 4.4 g/L. Case presentation The patient presented with hemodynamic instability and severe metabolic acidosis with pH 6.69. The anion gap was 39 mmol/L and the osmol gap 73 mosmol/kg. Treatment with ethanol and continuous venovenous hemodiafiltration (CVVH-DF was initiated. Despite the hemodynamic instability it is was possible to achieve rapid correction of pH and methanol concentration with CVVH-DF while maintaining a stable and therapeutic ethanol serum concentration. Despite hemodynamic and acid-base improvement, our patient developed massive cerebral edema leading to brain death. Permission for organ donation was unfortunately not ascertained. Conclusions We conclude that in a hemodynamic instable situation high methanol concentrations and methanol-induced derangements of homeostasis are safely and effectively treated with CVVH-DF and that severe cerebral edema is another possible cause of death rather than the classical bleeding in the putamen area.

  7. The Role of Localisation in Advertising Translation

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ying

    2016-01-01

    Today, a growing number of international corporations have been seeking to boost their sales on the global scale. To achieve this, adverting, one of the most common way to stimulate consumption, is widely used in which translation is involved because of diverse languages. Thus, how to translate a source advertising in a target culture has a decisive influence on a compa-ny’s marketing. The aim of the target advertising is to sell products to the locals. In this sense, localisation plays a significant role in the translation of advertising. This essay will discuss the importance of localisation in the translation of advertising and analyse cases of English-Chinese advertising translation based on the purpose of advertising and advertising translation.

  8. Modelling localised fracture of reinforced concrete structures

    OpenAIRE

    Liao, F; Huang, Z.

    2015-01-01

    This paper presents a robust finite element procedure for simulating the localised fracture of reinforced concrete members. In this new model the concrete member is modelled as an assembly of plain concrete, reinforcing steel bar and bond-link elements. The 4-node quadrilateral elements are used for 2D modelling of plain concrete elements, in which the extended finite element method is adopted to simulate the formation and growth of individual cracks. The reinforcing steel bars are modelled b...

  9. Geographical localisation of the geomagnetic secular variation

    OpenAIRE

    Aubert, Julien; Finlay, Chris; Olsen, Nils

    2013-01-01

    Directly observed changes in Earth’s magnetic field occur most prominently at low latitudes beneath the Atlantic hemisphere, while the Pacific is comparatively quiet. This striking hemispheric asymmetry in geomagnetic secular variation is a consequence of the geographical localisation of intense, westward moving, magnetic flux patches at the core surface. Despite its successes in explaining the main morphological properties of Earth’s magnetic field, self-consistent numerical modelling of the...

  10. Superglue accidentally used as ear drops

    National Research Council Canada - National Science Library

    Anusha, Bala; Purushotman, R; Lina, L C; Avatar, S

    2012-01-01

    Superglue in the ear as a foreign body is an uncommon presentation. We report the case of a lady who accidentally instilled superglue directly onto her tympanic membrane and presented five days later...

  11. To localise or to be localised with WiFi in the Hubei museum?

    OpenAIRE

    E. Verbree; S. Zlatanova; Van Winden, K.B.A.; Laan, E. B.; Makri, A; L. Taizhou; Haojun, A.

    2013-01-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the commonly known fingerprinting method for the purpose of a 3D indoor navigation system. Ttwo different WiFi based localisation techniques are tested during the MSc Geomatics DaRen Syntheses P...

  12. The use of commercial glass as a potential gamma accidental dosimeter through the absorption spectra

    Energy Technology Data Exchange (ETDEWEB)

    Kharita, M.H., E-mail: prscientific1@aec.org.sy [Atomic Energy Commission, Damascus, P.O. Box 6091 (Syrian Arab Republic); Yousef, S.; Bakr, S. [Atomic Energy Commission, Damascus, P.O. Box 6091 (Syrian Arab Republic)

    2012-05-01

    Various types of commercial glass (ordinary windows, cathode ray tubes, glass kitchenware) have been studied as potential accidental radiation dosimeters. The proposed method utilizes the changes in the glasses' absorption spectra as a result of irradiation. A {sup 60}Co gamma irradiation cell has been used to irradiate samples with doses ranging from 5 to 200 Gy. The transmittance was measured using a photospectrometer (UV-visible spectrometry). The results demonstrate that the transmittance spectra of most of the glass samples change in linear proportion to the exposure dose. Moreover, the study considers the fading effect on the absorption spectra of the irradiated samples for fading times up to 100 days at room temperature. The results of this work demonstrate that several widely used types of glass can be used as high-dose accidental dosimeters for doses ranging between 8 and 200 Gy. A reasonable calibration line can be established for any irradiated glass sample by heating, re-irradiating with standard doses and measuring the related absorption coefficient. Further investigations are needed to decrease the minimum detectable dose of the proposed method and to study the effect of glass composition on radiation response.

  13. Mortalidad intrahospitalaria por accidente cerebrovascular

    Directory of Open Access Journals (Sweden)

    Federico Rodríguez Lucci

    2013-08-01

    Full Text Available La mortalidad global por accidente cerebrovascular (ACV ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Stroke de FLENI y los registros institucionales de mortalidad entre los años 2000 y 2010. Los subtipos de ACV isquémicos se clasificaron según criterios TOAST y los ACV hemorrágicos en hematomas intrapanquimatosos, hemorragias subaracnoideas aneurismáticas, malformaciones arteriovenosas y otros hematomas intraparenquimatosos. Se analizaron 1514 pacientes, 1079 (71% con ACV isquémico (grandes vasos 39%, cardioembólicos 27%, lacunares 9%, etiología indeterminada 14%, otras etiologías 11% y 435 (29% con ACV hemorrágico (intraparenquimatosos 27%, hemorragia subaracnoidea 30%, malformaciones arteriovenosas 25% y otros hematomas espontáneos 18%. Se registraron 38 muertes intrahospitalarias (17 ACV isquémicos y 21 ACV hemorrágicos, representando una mortalidad global del 2.5% (1.7% en ACV isquémicos y 4.8% en ACV hemorrágicos. No se registraron muertes asociadas al uso de fibrinolíticos endovenosos. La mortalidad intrahospitalaria en pacientes con ACV isquémico y hemorrágico en nuestro centro fue baja. El manejo en un centro dedicado a las enfermedades neurológicas y el enfoque multidisciplinario por personal médico y no médico entrenado en el cuidado de la enfermedad cerebrovascular podrían explicar, al menos en parte, estos resultados.

  14. Consistency and variability in functional localisers

    Science.gov (United States)

    Duncan, Keith J.; Pattamadilok, Chotiga; Knierim, Iris; Devlin, Joseph T.

    2009-01-01

    A critical assumption underlying the use of functional localiser scans is that the voxels identified as the functional region-of-interest (fROI) are essentially the same as those activated by the main experimental manipulation. Intra-subject variability in the location of the fROI violates this assumption, reducing the sensitivity of the analysis and biasing the results. Here we investigated consistency and variability in fROIs in a set of 45 volunteers. They performed two functional localiser scans to identify word- and object-sensitive regions of ventral and lateral occipito-temporal cortex, respectively. In the main analyses, fROIs were defined as the category-selective voxels in each region and consistency was measured as the spatial overlap between scans. Consistency was greatest when minimally selective thresholds were used to define “active” voxels (p < 0.05 uncorrected), revealing that approximately 65% of the voxels were commonly activated by both scans. In contrast, highly selective thresholds (p < 10− 4 to 10− 6) yielded the lowest consistency values with less than 25% overlap of the voxels active in both scans. In other words, intra-subject variability was surprisingly high, with between one third and three quarters of the voxels in a given fROI not corresponding to those activated in the main task. This level of variability stands in striking contrast to the consistency seen in retinotopically-defined areas and has important implications for designing robust but efficient functional localiser scans. PMID:19289173

  15. Topologically protected localised states in spin chains

    Science.gov (United States)

    Estarellas, Marta P.; D’Amico, Irene; Spiller, Timothy P.

    2017-02-01

    We consider spin chain families inspired by the Su, Schrieffer and Hegger (SSH) model. We demonstrate explicitly the topologically induced spatial localisation of quantum states in our systems. We present detailed investigations of the effects of random noise, showing that these topologically protected states are very robust against this type of perturbation. Systems with such topological robustness are clearly good candidates for quantum information tasks and we discuss some potential applications. Thus, we present interesting spin chain models which show promising applications for quantum devices.

  16. Isocitrate lyase localisation in Saccharomyces cerevisiae cells.

    Science.gov (United States)

    Chaves, R S; Herrero, P; Ordiz, I; Angeles del Brio, M; Moreno, F

    1997-10-01

    The isocitrate lyase from Saccharomyces cerevisiae was only located in the cell cytoplasm. This protein was found not to be associated with cell organelles, even under growth conditions that induce peroxisome proliferation. This conclusion is supported by experiments carried out by damaging the protoplast plasma membrane with DEAE-dextran, by differential centrifugation of osmotically lysed protoplast and by using the green fluorescent protein (GFP) of Aequorea victoria as a reporter fusion tag to localise the subcellular compartment to which isocitrate lyase is targeted.

  17. Comparing mobile robot localisation algorithms using Kalmtool

    DEFF Research Database (Denmark)

    Mogensen, Lars Valdemar; Hansen, Søren; Ravn, Ole

    2009-01-01

    In this paper we present an estimation platform with simulation capabilities to evaluate methods for localisation of a mobile robot using a feature map. The platform is based on the Kalmtool 4 toolbox which is a set of MATLAB tools for state estimation of nonlinear systems. The toolbox contains...... functions for extended Kalman filtering as well as for the DD1 filter and the DD2 filter. It also contains functions for Unscented Kalman filters as well as three versions of particle filters. The toolbox requires MATLAB version 7, but no additional toolboxes are required....

  18. To localise or to be localised with Wifi in the Hubei museum?

    NARCIS (Netherlands)

    Verbree, E.; Zlatanova, S.; Van Winden, K.; Van der Laan, E.B.; Makri, A.; Taizhou, L.; Haojun, A.

    2013-01-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the

  19. To localise or to be localised with Wifi in the Hubei museum?

    NARCIS (Netherlands)

    Verbree, E.; Zlatanova, S.; Van Winden, K.; Van der Laan, E.B.; Makri, A.; Taizhou, L.; Haojun, A.

    2013-01-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the co

  20. Hémangiome fusiforme: une localisation inhabituelle

    Science.gov (United States)

    Nasreddine, Fatima Zahra; Baghad, Bouchra; Chiheb, Soumiya

    2016-01-01

    L'hémangiome à cellules fusiformes été décrit par Weiss et Enzinger en 1986 et anciennement nommé hémangioendothéliome à cellules fusiformes. Depuis l'avènement des études immunohistochimique il n'est plus considéré en tant qu'angiosarcome de bas grade. C'est une tumeur bénigne vasculaire. Il touche presque exclusivement le derme des extrémités distales. Nous rapportons le premier cas avec localisation au niveau de l'omoplate, du sein, des cuisses et de la mandibule. Selon la littérature, seulement 9 cas localisés au niveau de la tête et le cou ont été rapportés. Nous rapportons un nouveau cas de cette entité rare et mal connue qui peut prêter confusion avec les tumeurs malignes. Notre patient avait une localisation au niveau de l'omoplate, du sein, des cuisses et de la mandibule. Une biopsie-exérèse était réalisée. L’évolution a été favorable avec un recul de 6 mois, sans rechute. PMID:27642429

  1. Backreaction of Localised Sources in String Compactifications

    CERN Document Server

    Junghans, Daniel

    2013-01-01

    Localised sources such as D-branes or orientifold planes play an important role in many string compactifications that are relevant for phenomenology. The presence of these objects typically induces complicated dynamics in the compact dimensions such that a full solution to the 10d equations of motion is often out of reach. In order to still be able to make statements about the 4d effective theory arising in the low-energy limit, the equations of motion are usually only solved in an integrated sense, while the backreaction of the localised sources on the internal fields is neglected. This simplification is often referred to as smearing. In this work, we investigate to what extent smearing may affect observables in the effective low-energy theory and whether it may lead to fake solutions that would cease to exist once the backreaction is properly taken into account. We analyse explicit examples for which smeared solutions exist and find that the reliability of the smeared approximation appears to depend on whet...

  2. An innovative localisation algorithm for railway vehicles

    Science.gov (United States)

    Allotta, B.; D'Adamio, P.; Malvezzi, M.; Pugi, L.; Ridolfi, A.; Rindi, A.; Vettori, G.

    2014-11-01

    In modern railway automatic train protection and automatic train control systems, odometry is a safety relevant on-board subsystem which estimates the instantaneous speed and the travelled distance of the train; a high reliability of the odometry estimate is fundamental, since an error on the train position may lead to a potentially dangerous overestimation of the distance available for braking. To improve the odometry estimate accuracy, data fusion of different inputs coming from a redundant sensor layout may be used. The aim of this work has been developing an innovative localisation algorithm for railway vehicles able to enhance the performances, in terms of speed and position estimation accuracy, of the classical odometry algorithms, such as the Italian Sistema Controllo Marcia Treno (SCMT). The proposed strategy consists of a sensor fusion between the information coming from a tachometer and an Inertial Measurements Unit (IMU). The sensor outputs have been simulated through a 3D multibody model of a railway vehicle. The work has provided the development of a custom IMU, designed by ECM S.p.a, in order to meet their industrial and business requirements. The industrial requirements have to be compliant with the European Train Control System (ETCS) standards: the European Rail Traffic Management System (ERTMS), a project developed by the European Union to improve the interoperability among different countries, in particular as regards the train control and command systems, fixes some standard values for the odometric (ODO) performance, in terms of speed and travelled distance estimation. The reliability of the ODO estimation has to be taken into account basing on the allowed speed profiles. The results of the currently used ODO algorithms can be improved, especially in case of degraded adhesion conditions; it has been verified in the simulation environment that the results of the proposed localisation algorithm are always compliant with the ERTMS requirements

  3. Differences in finger localisation performance of patients with finger agnosia.

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; Haan, E.H.F. de; Kappelle, L.J.; Leijten, F.S.S.; Zandvoort, M.J. Van; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on one's own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports describ

  4. Differences in finger localisation performance of patients with finger agnosia

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; Haan, E.H.F. de; Kappelle, L.J.; Leijten, F.S.S.; Zandvoort, M.J.E. van; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on ones own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports describe

  5. Amelogenesis imperfecta and localised aggressive periodontitis: A rare clinical entity.

    Science.gov (United States)

    Gundannavar, Gayatri; Rosh, Radhika M; Chandrasekaran, Shoba; Hussain, Ahad M

    2013-01-01

    This case report presents two female patients whose chief complaint was discoloration of teeth. On careful clinical examination it was found that the patients had features of amelogenesis imperfecta and localised aggressive periodontitis. This article will give an insight of clinical and radiographic features of amelogenesis imperfecta with localised aggressive periodontitis, which is a rare clinical entity.

  6. Differences in finger localisation performance of patients with finger agnosia.

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; Haan, E.H.F. de; Kappelle, L.J.; Leijten, F.S.S.; Zandvoort, M.J. Van; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on one's own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports

  7. Differences in finger localisation performance of patients with finger agnosia

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; Haan, E.H.F. de; Kappelle, L.J.; Leijten, F.S.S.; Zandvoort, M.J.E. van; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on ones own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports describe

  8. Differences in finger localisation performance of patients with finger agnosia

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; de Haan, E.H.F.; Kappelle, L.J.; Leijten, F.S.; van Zandvoort, M.J.E.; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on one's own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports

  9. Underwater Acoustic Source Localisation Among Blind and Sighted Scuba Divers

    Science.gov (United States)

    Cambi, Jacopo; Livi, Ludovica; Livi, Walter

    2017-01-01

    Objectives Many blind individuals demonstrate enhanced auditory spatial discrimination or localisation of sound sources in comparison to sighted subjects. However, this hypothesis has not yet been confirmed with regards to underwater spatial localisation. This study therefore aimed to investigate underwater acoustic source localisation among blind and sighted scuba divers. Methods This study took place between February and June 2015 in Elba, Italy, and involved two experimental groups of divers with either acquired (n = 20) or congenital (n = 10) blindness and a control group of 30 sighted divers. Each subject took part in five attempts at an under-water acoustic source localisation task, in which the divers were requested to swim to the source of a sound originating from one of 24 potential locations. The control group had their sight obscured during the task. Results The congenitally blind divers demonstrated significantly better underwater sound localisation compared to the control group or those with acquired blindness (P = 0.0007). In addition, there was a significant correlation between years of blindness and underwater sound localisation (P sound in an underwater environment. As the correct localisation of sounds underwater may help individuals to avoid imminent danger, divers should perform sound localisation tests during training sessions. PMID:28690888

  10. Amelogenesis imperfecta and localised aggressive periodontitis: A rare clinical entity

    Directory of Open Access Journals (Sweden)

    Gayatri Gundannavar

    2013-01-01

    Full Text Available This case report presents two female patients whose chief complaint was discoloration of teeth. On careful clinical examination it was found that the patients had features of amelogenesis imperfecta and localised aggressive periodontitis. This article will give an insight of clinical and radiographic features of amelogenesis imperfecta with localised aggressive periodontitis, which is a rare clinical entity.

  11. Accidental fire in the West Hall

    CERN Document Server

    1977-01-01

    On January 7 an accidental fire due to the failure of standard circuit-breakers, destroyed the coils of two spectrometer magnets and severely damaged the apparatus of two experiments. See also photos 7701582X, 7701581X, 7701580X. (Annual Report 1977, pg. 127-128)

  12. Accidental oxygen disconnection in the emergency department

    Directory of Open Access Journals (Sweden)

    Hill Guyon

    2010-01-01

    Full Text Available Accidental oxygen disconnection during rapid sequence intubation (RSI in the emergency department is a potentially catastrophic yet avoidable event. We report three cases of inadvertent oxygen disconnection during RSI, which resulted in significant oxygen desaturation. This error can potentially be prevented by thorough preparation, focusing on teamwork training, ensuring an ergonomic environment, and by making simple modifications to existing equipment.

  13. accidental injuries and cutaneous contaminations during general ...

    African Journals Online (AJOL)

    2003-05-01

    May 1, 2003 ... accidental injuries, blood and body fluids contaminations are becoming life ... glove with the skin of the hand or fingers establishing direct contact with blood ..... susceptible to skin breaks on the finger tips; the site of majority of ...

  14. Nickel, Zn and Cd localisation in seeds of metal hyperaccumulators using μ-PIXE spectroscopy

    Science.gov (United States)

    Kachenko, Anthony G.; Bhatia, Naveen P.; Siegele, Rainer; Walsh, Kerry B.; Singh, Balwant

    2009-06-01

    Metal hyperaccumulators are a rare group of plant species that accumulate exceptionally high concentrations of metals in above ground tissues without showing symptoms of phytotoxicity. Quantitative localisation of the accumulated metals in seed tissues is of considerable interest to help understand the eco-physiology of these unique plant species. We investigated the spatial localisation of metals within seeds of Ni hyperaccumulating Hybanthus floribundus subsp. adpressus, H. floribundus subsp. floribundus and Pimelea leptospermoides and dual-metal (Cd and Zn) hyperaccumulating Thlaspi caerulescens using quantitative micro-proton induced X-ray emission (μ-PIXE) spectroscopy. Intact seeds were hand-sectioned, sandwiched between Formvar films and irradiated using the 3 MeV high energy heavy ion microprobe at ANSTO. Elemental maps of whole H. floribundus subsp. adpressus seeds showed an average Ni concentration of 5.1 × 10 3 mg kg -1 dry weight (DW) with highest Ni concentration in cotyledonary tissues (7.6 × 10 3 mg kg -1 DW), followed by the embryonic axis (4.4 × 10 3 mg kg -1 DW). Nickel concentration in whole H. floribundus subsp. floribundus seeds was 3.5 × 10 2 mg kg -1 DW without a clear pattern of Ni localisation. The average Ni concentration in whole P. leptospermoides seeds was 2.6 × 10 2 mg kg -1 DW, and Ni was preferentially localised in the embryonic axis (4.3 × 10 2 mg kg -1 DW). In T. caerulescens, Cd concentrations were similar in cotyledon (4.5 × 10 3 mg kg -1 DW) and embryonic axis (3.3 × 10 3 mg kg -1 DW) tissues, whereas Zn was highest in cotyledonary tissues (1.5 × 10 3 mg kg -1 DW). In all species, the presence of the accumulated metal within the cotyledonary and embryonic axis tissues indicates that the accumulated metal was able to move apoplastically within the seed.

  15. Localisation and World Modelling: an Architectural Perspective

    Directory of Open Access Journals (Sweden)

    Domenico G. Sorrenti

    2008-11-01

    Full Text Available Autonomous robot world modelling is a "chicken-and-egg" problem: position estimation needs a model of the world, whereas world modelling needs the robot position. Most of the works dealing with this issue propose holistic solutions under an algorithmic perspective by neglecting software architecture issues. This results in huge and monolithic pieces of software where implementation details reify strategic decisions. An architectural approach founded on separation of concerns may help to break the loop. Localisation and modelling, acting on different time scales, are mostly independent of each other. Sometimes synchronisation is required. Whenever needed, an external strategy tunes the relative rates of the two activities. The paper introduces rationale, design, and implementation of such a system which relies on Real-Time Performers, a software architecture providing suitable architectural abstractions to observe and control the system's temporal behaviour.

  16. Reaction-Diffusion Automata Phenomenology, Localisations, Computation

    CERN Document Server

    Adamatzky, Andrew

    2013-01-01

    Reaction-diffusion and excitable media are amongst most intriguing substrates. Despite apparent simplicity of the physical processes involved the media exhibit a wide range of amazing patterns: from target and spiral waves to travelling localisations and stationary breathing patterns. These media are at the heart of most natural processes, including morphogenesis of living beings, geological formations, nervous and muscular activity, and socio-economic developments.   This book explores a minimalist paradigm of studying reaction-diffusion and excitable media using locally-connected networks of finite-state machines: cellular automata and automata on proximity graphs. Cellular automata are marvellous objects per se because they show us how to generate and manage complexity using very simple rules of dynamical transitions. When combined with the reaction-diffusion paradigm the cellular automata become an essential user-friendly tool for modelling natural systems and designing future and emergent computing arch...

  17. Understanding localisation in QCD through an Ising-Anderson model

    CERN Document Server

    Giordano, Matteo; Pittler, Ferenc

    2014-01-01

    Above the QCD chiral crossover temperature, the low-lying eigenmodes of the Dirac operator are localised, while moving up in the spectrum states become extended. This localisation/delocalisation transition has been shown to be a genuine second-order phase transition, in the same universality class as that of the 3D Anderson model. The existence of localised modes and the effective dimensional reduction can be tentatively explained as a consequence of local fluctuations of the Polyakov loop, that provide 3D on-site disorder, in analogy to the on-site disorder of the Anderson model. To test the viability of this explanation we study a 3D effective, Anderson-like model, with on-site disorder provided by the spins of a spin model, which mimics the Polyakov loop dynamics. Our preliminary results show that localised modes are present in the ordered phase, thus supporting the proposed mechanism for localisation in QCD.

  18. Localised states in an extended Swift-Hohenberg equation

    CERN Document Server

    Burke, John

    2011-01-01

    Recent work on the behaviour of localised states in pattern forming partial differential equations has focused on the traditional model Swift-Hohenberg equation which, as a result of its simplicity, has additional structure --- it is variational in time and conservative in space. In this paper we investigate an extended Swift-Hohenberg equation in which non-variational and non-conservative effects play a key role. Our work concentrates on aspects of this much more complicated problem. Firstly we carry out the normal form analysis of the initial pattern forming instability that leads to small-amplitude localised states. Next we examine the bifurcation structure of the large-amplitude localised states. Finally we investigate the temporal stability of one-peak localised states. Throughout, we compare the localised states in the extended Swift-Hohenberg equation with the analogous solutions to the usual Swift-Hohenberg equation.

  19. 5 CFR 870.206 - Accidental death and dismemberment.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' GROUP LIFE INSURANCE PROGRAM Types and Amount of Insurance § 870..., accidental death benefits are equal to the amount of Option A. (c)(1) Under Basic insurance, accidental... automatic part of Basic and Option A insurance for employees. (2) There is no accidental death...

  20. To localise or to be localised with WiFi in the Hubei museum?

    Science.gov (United States)

    Verbree, E.; Zlatanova, S.; van Winden, K. B. A.; van der Laan, E. B.; Makri, A.; Taizhou, L.; Haojun, A.

    2013-11-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the commonly known fingerprinting method for the purpose of a 3D indoor navigation system. Ttwo different WiFi based localisation techniques are tested during the MSc Geomatics DaRen Syntheses Project in the Hubei Provincial Museum, China. The first method detects the beacon frames send by smartphones, laptops and other WiFi enabled devices in range using Libelium Meshlium Xtreme monitors. Their MAC addresses and the signal strength is measured by the Meshlium Xtreme and stored on an external database. We call this method WiFi monitoring. The second method a Wifi enabled device, like a smartphone, measures the signal strength of multiple Wifi Access Points in range to localise itself based on a previously created radio map. This method is known as WiFi fingerprinting. Both methods have some advantages and disadvantages. Advantages of the common way of WiFi fingerprinting are that the implementation costs are relatively low, because it is usually possible to use (a part of) the existing WiFi AP infrastructure. WiFi fingerprinting can reach a relatively high accuracy in the order of magnitude of meters. Finally, the location granularity can be adjusted to what is necessary for the purpose of the indoor localisation. This makes it employable for a wide range of purposes. The question remains how suitable these methods are for a 3D indoor navigation system for the Hubei provincial museum. One important aspect is the localisation-granularity necessary for the application. In a museum it is not necessary to know the exact X,Y position of a user (such high accuracy is unnecessary), more important is to know in which room the user is located so the information on exhibitions can be

  1. Accidental ingestion of Ecstasy in a toddler.

    Science.gov (United States)

    Chang, Yi-Jung; Lai, Ming-Wei; Kong, Man-Shan; Chao, Hsun-Chin

    2005-12-01

    Toddlers who ingest the drug of abuse 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') are at particularly high risk of serious neurological and cardiovascular side effects. We report of a 20-month-old male toddler who accidentally ingested Ecstasy. He presented with fever and seizures, tachycardia, hypertension, and hyperthermia. Urine amphetamine level was 2111 ng/mL. Treatment included rapid cooling, hydration, and support measures. Vital signs were regularly monitored. His condition became stable on day 2 and urine amphetamine level returned to normal on day 3 of hospitalization. His behavior, activity, and appetite had returned to their usual levels upon follow-up at our outpatient clinic. The incidence of drug abuse with MDMA has increased dramatically over the last decade in developed countries. It can be expected that accidental Ecstasy poisoning in children will increase as well. This case illustrates the need to consider the possibility of accidental Ecstasy ingestion in the differential diagnosis of a child suffering from convulsions with fever.

  2. Generalised two target localisation using passive monopulse radar

    KAUST Repository

    Jardak, Seifallah

    2017-04-07

    The simultaneous lobing technique, also known as monopulse technique, has been widely used for fast target localisation and tracking purposes. Many works focused on accurately localising one or two targets lying within a narrow beam centred around the monopulse antenna boresight. In this study, a new approach is proposed, which uses the outputs of four antennas to rapidly localise two point targets present in the hemisphere. If both targets have the same elevation angle, the proposed scheme cannot detect them. To detect such targets, a second set of antennas is required. In this study, to detect two targets at generalised locations, the antenna array is divided into multiple overlapping sets each of four antennas. Two algorithms are proposed to combine the outputs from multiple sets and improve the detection performance. Simulation results show that the algorithm is able to localise both targets with <;2° mean square error in azimuth and elevation.

  3. Range-only Target Localisation using Geometrically Constrained Optimisation

    Directory of Open Access Journals (Sweden)

    En Fan

    2015-03-01

    Full Text Available The problem of optimal range-only localisation of a single target is of considerable interest in two-dimensional search radar networking. For coping with this problem, a range-only target localisation method using synchronous measurements from radars is presented in the real ellipsoidal earth model. In the relevant radar localisation scenario, geometric relationships between the target and three radars were formed. A set of localisation equations was derived on range error in such a scenario. Using these equations, the localisation task has been formulated as a nonlinear weighted least squares problem that can be performed using the Levenberg- Marquardt (LM algorithm to provide the optimal estimate of the target’s position. To avoid the double value solutions and to accelerate the convergence speed for the LM algorithm, the initial value was approximately given according to observations from two radars. In addition, the relative validity has been defined to evaluate the performance of the proposed method. The performance of the proposed approach is evaluated using two simulation experiments and a real-test experiment, and it has been found to possess higher localisation accuracy than the other conventional method.Defence Science Journal, Vol. 65, No. 1, January 2015, pp.70-76, DOI:http://dx.doi.org/10.14429/dsj.65.5474

  4. Indoor Localisation Based on GSM Signals: Multistorey Building Study

    Directory of Open Access Journals (Sweden)

    Rafał Górak

    2016-01-01

    Full Text Available Among the accurate indoor localisation systems that are using WiFi, Bluetooth, or infrared technologies, the ones that are based on the GSM rely on a stable external infrastructure that can be used even in an emergency. This paper presents an accurate GSM indoor localisation system that achieves a median error of 4.39 metres in horizontal coordinates and up to 64 percent accuracy in floor prediction (for 84 percent of cases the floor prediction is mistaken by not more than a single floor. The test and reference measurements were made inside a six-floor academic building, with an irregular shape, whose dimensions are around 50 metres by 70 metres. The localisation algorithm uses GSM signal readings from the 7 strongest cells available in the GSM standard (or fewer, if fewer than 7 are available. We estimate the location by a three-step method. Firstly, we propose a point localisation solution (i.e., localisation based on only one measurement. Then, by applying the central tendency filters and the Multilayer Perceptron, we build a localisation system that uses a sequence of estimations of current and past locations. We also discuss major accuracy factors such as the number of observed signals or the types of spaces in the building.

  5. Accidental K\\"ahler Moduli Inflation

    CERN Document Server

    Maharana, Anshuman; Sumitomo, Yoske

    2015-01-01

    We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small K\\"ahler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil K\\"ahler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model.

  6. Accidental Kähler moduli inflation

    Energy Technology Data Exchange (ETDEWEB)

    Maharana, Anshuman [Harish Chandra Research Institute,Chhatnag Road, Jhunsi, Allahabad, UP 211019 (India); Rummel, Markus [Rudolph Peierls Centre for Theoretical Physics, University of Oxford,1 Keble Road, Oxford, OX1 3NP (United Kingdom); Sumitomo, Yoske [High Energy Accelerator Research Organization, KEK,1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2015-09-14

    We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small Kähler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil Kähler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model.

  7. Accidental Ingestion of 35% Hydrogen Peroxide

    Directory of Open Access Journals (Sweden)

    Sean Pritchett

    2007-01-01

    Full Text Available Hydrogen peroxide is a commonly used oxidizing agent with a variety of uses depending on its concentration. Ingestion of hydrogen peroxide is not an uncommon source of poisoning, and results in morbidity through three main mechanisms: direct caustic injury, oxygen gas formation and lipid peroxidation. A case of a 39-year-old man who inadvertently ingested 250 mL of unlabelled 35% hydrogen peroxide intended for natural health use is presented. Hydrogen peroxide has purported benefits ranging from HIV treatment to cancer treatment. Its use in the natural health industry represents an emerging source for accidental poisonings.

  8. Anaphylaxis after accidental ingestion of kiwi fruit.

    Science.gov (United States)

    Gawrońska-Ukleja, Ewa; Różalska, Anna; Ukleja-Sokołowska, Natalia; Zbikowska-Gotz, Magdalena; Bartuzi, Zbigniew

    2013-06-01

    Numerous cases of anaphylaxis after ingestion of kiwi fruit, after the skin tests and during oral immunotherapy were described. The article describes the case of severe anaphylactic reaction that occurred in a 55-year-old patient after accidental ingestion of kiwi. Allergy to kiwi fruit was confirmed by a native test with fresh kiwi fruit. After the test, the patient experienced generalized organ response in the form of headache, general weakness and rashes on the neck and breast, and dyspnea. The patient had significantly elevated levels of total IgE and IgE specific to kiwi fruit.

  9. Tratamiento del virus de hepatitis B en el accidente laboral

    Directory of Open Access Journals (Sweden)

    Henry Zamora-Barquero

    2008-11-01

    Full Text Available La exposición accidental al virus B entraña alto riesgo de contagio de la enfermedad. Su manejo incluye: medidas preventivas en el manejo de los pacientes, vacunar y confirmar inmunidad de los trabajadores, uso de inmunoglobulinas y vacunación posterior al accidente y disponer de protocolos de reporte precoz y clínicas en el manejo de los accidentes.

  10. Outcome of accidental hypothermia with or without circulatory arrest

    DEFF Research Database (Denmark)

    Wanscher, Michael; Agersnap, Lisbeth; Ravn, Jesper;

    2012-01-01

    Resuscitation guidelines for the treatment of accidental hypothermia are based primarily on isolated cases. Mortality rates are high despite aggressive treatment aimed at restoring spontaneous circulation and normothermia....

  11. El accidente de trabajo "in itinere": concepto legal y jurisprudencial

    OpenAIRE

    López Mejías, Ana

    2016-01-01

    El trabajo que voy a llevar a cabo trata sobre el accidente de trabajo, más en concreto el accidente de trabajo "in itinere", ya que es un hecho protegido que la ley general de la seguridad social le da una gran importancia. Trataré los requisitos necesarios para que se dé un accidente de trabajo "in itinere", basándome siempre en sentencias ya que es un trabajo básicamente jurisprudencial. En el trabajo también trato el accidente de trabajo in mision. A modo de conclusión expresaré mi opinió...

  12. Medical management of accidentally exposed individuals

    Energy Technology Data Exchange (ETDEWEB)

    Nenot, Jean-Claude [CEA Centre d`Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire

    1997-12-31

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Although both transfusion and bone marrow transplantation have been used with some success since the first treatments of patients, other therapeutic strategies are needed. New promising approaches of the treatment of aplasia have appeared with the development of experimental and clinical hematology. Some new trends for the treatment of the hematopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. The hematopoietic growth factors stimulate proliferation and/or differentiation of hematopoietic progenitors and possibly stem cells. Furthermore, they act on the functions of mature cells. They have now specific uses in hematology, related to their role in the regulation of growth and differentiation of hematopoietic progenitor cells. Some growth factors have already been used for the treatment of accidental radiation-induced aplasia and lessons have been learned from their medical management and follow-up. (author) 30 refs.

  13. Accidentes de tránsito terrestre

    Directory of Open Access Journals (Sweden)

    José Enrique Ramírez Muñoz

    2013-09-01

    Full Text Available Los accidentes de tránsito terrestres en Costa Rica se han convertido en un serio problema de salud pública, que derivan ya sea en lesiones graves o bien en muertes de personas de todas las edades. Estos eventos incluyen el atropellamiento, las colisiones y choques, y producen cuadros lesionológicos muy diversos de acuerdo a la participación de las personas, el tipo de vehículo y la forma en la que se produce el traumatismo. Así mismo, se debe tener en cuenta la participación de factores coadyuvantes como el uso del casco y el cinturón de seguridad, o bien el consumo de alcohol y el uso del teléfono móvil. La valoración médico legal de las víctimas, vivas o muertas de accidentes de tránsito, está a cargo del Departamento de Medicina Legal del Organismo de Investigación Judicial, y se hace por solicitud de una Autoridad Judicial competente.

  14. On localised hotspots of an urban crime model

    Science.gov (United States)

    Lloyd, David J. B.; O'Farrell, Hayley

    2013-06-01

    We investigate stationary, spatially localised crime hotspots on the real line and the plane of an urban crime model of Short et al. [M. Short, M. DÓrsogna, A statistical model of criminal behavior, Mathematical Models and Methods in Applied Sciences 18 (2008) 1249-1267]. Extending the weakly nonlinear analysis of Short et al., we show in one-dimension that localised hotspots should bifurcate off the background spatially homogeneous state at a Turing instability provided the bifurcation is subcritical. Using path-following techniques, we continue these hotspots and show that the bifurcating pulses can undergo the process of homoclinic snaking near the singular limit. We analyse the singular limit to explain the existence of spike solutions and compare the analytical results with the numerical computations. In two-dimensions, we show that localised radial spots should also bifurcate off the spatially homogeneous background state. Localised planar hexagon fronts and hexagon patches are found and depending on the proximity to the singular limit these solutions either undergo homoclinic snaking or act like “multi-spot” solutions. Finally, we discuss applications of these localised patterns in the urban crime context and the full agent-based model.

  15. In normal human fibroblasts variation in DSB repair capacity cannot be ascribed to radiation-induced changes in the localisation, expression or activity of major NHEJ proteins

    DEFF Research Database (Denmark)

    Kasten-Pisula, Ulla; Vronskaja, Svetlana; Overgaard, Jens

    2008-01-01

    BACKGROUND AND PURPOSE: The aim of the present study was to test whether for normal human fibroblasts the variation in double-strand break (DSB) repair capacity results from radiation-induced differences in localisation, expression or activity of major non-homologous end-joining (NHEJ) proteins....... MATERIALS AND METHODS: Experiments were performed with 11 normal human fibroblast strains AF01-11. NHEJ proteins were determined by Western blot and DNA-PK activity by pulldown-assay. RESULTS: The four NHEJ proteins tested (Ku70, Ku80, XRCC4 and DNA-PKcs) were found to be localised almost exclusively...... in the activity of the DNA-PK complex induced upon irradiation. CONCLUSIONS: For normal human fibroblasts, the level or activity of NHEJ proteins measured prior to or after irradiation cannot be used to predict the DSB repair capacity or cellular radiosensitivity. Udgivelsesdato: 2008-Mar...

  16. Voronoi-based localisation algorithm for mobile sensor networks

    Science.gov (United States)

    Guan, Zixiao; Zhang, Yongtao; Zhang, Baihai; Dong, Lijing

    2016-11-01

    Localisation is an essential and important part in wireless sensor networks (WSNs). Many applications require location information. So far, there are less researchers studying on mobile sensor networks (MSNs) than static sensor networks (SSNs). However, MSNs are required in more and more areas such that the number of anchor nodes can be reduced and the location accuracy can be improved. In this paper, we firstly propose a range-free Voronoi-based Monte Carlo localisation algorithm (VMCL) for MSNs. We improve the localisation accuracy by making better use of the information that a sensor node gathers. Then, we propose an optimal region selection strategy of Voronoi diagram based on VMCL, called ORSS-VMCL, to increase the efficiency and accuracy for VMCL by adapting the size of Voronoi area during the filtering process. Simulation results show that the accuracy of these two algorithms, especially ORSS-VMCL, outperforms traditional MCL.

  17. Chiral transition, eigenmode localisation and Anderson-like models

    CERN Document Server

    Giordano, Matteo; Pittler, Ferenc

    2016-01-01

    We discuss chiral symmetry restoration and eigenmode localisation in finite-temperature QCD by looking at the lattice Dirac operator as a random Hamiltonian. We argue that the features of QCD relevant to both phenomena are the presence of order in the Polyakov line configuration, and the correlations that this induces between spatial links across time slices. This ties the fate of chiral symmetry and of localisation of the lowest Dirac eigenmodes to the confining properties of the theory. We then show numerical results obtained in a QCD-inspired Anderson-like toy model, derived by radically simplifying the QCD dynamics while keeping the important features mentioned above. The toy model reproduces all the important qualitative aspects of chiral symmetry breaking and localisation in QCD, thus supporting the central role played by the confinement/deconfinement transition in triggering both phenomena.

  18. Scintigraphic localisation of colonic bleeding; Scintigrafisk lokalisasjon av colonbloedning

    Energy Technology Data Exchange (ETDEWEB)

    Aspevik, Ranveig K.; Miskowiak, Jerzy; I Bud, Margreta

    2001-07-01

    Background. Endoscopy and occasionally X-ray studies are used to discover the focus of a gastrointestinal bleeding. Material and methods. We describe a case of severe gastrointestinal bleeding where these methods failed. Scintigraphy after labelling of erythrocytes with 99m technetium was performed in a continuos manner for 60 minutes. Scintigrams were also taken three, ten and 23 hours after the injection. Results. No bleeding was revealed after 60 minutes but two hours later a slight radioactivity was encountered in the right part of the abdomen and the later images localised the bleeding in the right colon. The bleeding ceased after right-sided hemicolectomy. Interpretation. Scintigraphy is of value in localisation of gastrointestinal bleeding and should be performed in a continuos manner until the bleeding focus is localised. Secretion of unbound technetium through the mucosa of the stomach and its presence in the urinary tract should be taken in account.

  19. Differences in finger localisation performance of patients with finger agnosia.

    Science.gov (United States)

    Anema, Helen A; Kessels, Roy P C; de Haan, Edward H F; Kappelle, L Jaap; Leijten, Frans S; van Zandvoort, Martine J E; Dijkerman, H Chris

    2008-09-17

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on one's own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports describe patients with impaired detection, but intact sensorimotor localisation. This study examined three patients with a lesion of the angular gyrus with intact somatosensory processing, but with selectively disturbed finger identification (finger agnosia). These patients performed normally when pointing towards the touched finger on their own hand but failed to indicate this finger on a drawing of a hand or to name it. Similar defects in the perception of other body parts were not observed. The findings provide converging evidence for the dissociation between body image and body schema and, more importantly, reveal for the first time that this distinction is also present in higher-order cognitive processes selectively for the fingers.

  20. Anderson localisation of visible light on a nanophotonic chip

    CERN Document Server

    Crane, Tom; Sapienza, Luca

    2016-01-01

    Controlling the propagation of visible light on a chip is of tremendous interest in research areas such as energy harvesting, imaging, sensing and biology. Technological advances allow us to control light at the nanoscale and to strongly enhance the light-matter interaction in highly engineered devices. However, compared to state-of-the-art two-dimensional optical cavities operating at longer wavelengths, the quality factor of on-chip visible light confinement is several orders of magnitude lower. Our approach makes use of fabrication imperfections to trap light: we demonstrate, for the first time, Anderson localisation of visible light on a chip. Remarkably, compared to quality factors of engineered cavities, disorder-induced localisation proves to be more efficient in trapping light than highly engineered devices, thus reversing the trend observed so far. We measure light-confinement quality factors as high as 7600 and, by implementing a sensitive imaging technique, we directly visualise the localised modes...

  1. Fully localised nonlinear energy growth optimals in pipe flow

    CERN Document Server

    Pringle, Chris C T; Kerswell, Rich R

    2014-01-01

    A new, fully-localised, energy growth optimal is found over large times and in long pipe domains at a given mass flow rate. This optimal emerges at a threshold disturbance energy below which a nonlinear version of the known (streamwise-independent) linear optimal (Schmid \\& Henningson 1994) is selected, and appears to remain the optimal up until the critical energy at which transition is triggered. The form of this optimal is similar to that found in short pipes (Pringle et al.\\ 2012) albeit now with full localisation in the streamwise direction. This fully-localised optimal perturbation represents the best approximation yet of the {\\em minimal seed} (the smallest perturbation capable of triggering a turbulent episode) for `real' (laboratory) pipe flows.

  2. Tension pneumothorax following an accidental kerosene poisoning: A case report

    Directory of Open Access Journals (Sweden)

    G M Ashir

    2009-01-01

    Full Text Available Tension pneumothorax is a rare complication following an accidental kerosene poisoning. In such situation, a bed-side needle thoracocentesis is performed because of its potential of becoming fatal; hence its clinical importance. A case of 15 month old boy with tension pneumothorax following accidental kerosene poisioning that responded to needle thoracocentesis is presented.

  3. Course Management Systems for Learning: Beyond Accidental Pedagogy

    Science.gov (United States)

    McGee, Patricia; Carmean, Colleen; Jafari, Ali

    2005-01-01

    "Course Management Systems for Learning: Beyond Accidental Pedagogy" is a comprehensive overview of standards, practices and possibilities of course management systems in higher education. "Course Management Systems for Learning: Beyond Accidental Pedagogy" focuses on what the current knowledge is (in best practices, research, standards and…

  4. 21 CFR 1002.20 - Reporting of accidental radiation occurrences.

    Science.gov (United States)

    2010-04-01

    ... Occurrences § 1002.20 Reporting of accidental radiation occurrences. (a) Manufacturers of electronic products... the Director, Center for Devices and Radiological Health, all accidental radiation occurrences... radiation occurrence occurred; (3) The manufacturer, type, and model number of the electronic product...

  5. Tension pneumothorax following an accidental kerosene poisoning: A case report

    OpenAIRE

    2009-01-01

    Tension pneumothorax is a rare complication following an accidental kerosene poisoning. In such situation, a bed-side needle thoracocentesis is performed because of its potential of becoming fatal; hence its clinical importance. A case of 15 month old boy with tension pneumothorax following accidental kerosene poisioning that responded to needle thoracocentesis is presented.

  6. Rickettsial infection caused by accidental conjunctival inoculation

    Science.gov (United States)

    Brissos, Joao; de Sousa, Rita; Santos, Ana Sofia; Gouveia, Catarina

    2015-01-01

    The most common transmission route of tick-borne Rickettsia is through tick bite; nevertheless, other transmission routes should also be considered. We report a case of rickettsial infection in a 15-year-old boy caused by accidental contamination of the conjunctiva through the infected fluid of a crushed engorged tick removed from a dog. Right eye pain, conjunctival hyperaemia with mucopurulent exudate, chemosis and eyelid oedema were the first signs and symptoms. Two days later, the boy developed fever, myalgia, headache, abdominal pain and was vomiting; physical examination showed multiple cervical adenopathies but no rash. He was treated with doxycycline (200 mg/day) for 7 days with progressive resolution of clinical signs. Rickettsial infection was confirmed by immunofluorescence assay with serological seroconversion in two consecutive samples. Rickettsia conorii or Rickettsia massiliae were the possible causal agents since they are the Rickettsia spp found in the Rhipicephalus sanguineus dog tick in Portugal. PMID:25568272

  7. Accidental Contamination with Oil during Endodontic Surgery.

    Science.gov (United States)

    Plascencia, Hugo; Díaz, Mariana; Cholico, Patricia; Del Real, Monserrat; Márquez-de Alba, Salvador

    2016-01-01

    The modern surgical endodontic treatment is a safe and predictable procedure with high success rate. However, several factors can retard or impede the proper healing process. Use of a high speed handpiece during hard tissues management (osteotomy and apical resection) can potentially be one of these factors. Formation of metallic debris from the surgical diamond burs, production of necrotic local tissue due to overheating and the direct liberation of air from conventional handpiece into the working area are potential irritants able to delay the tissue healing. The aim of the present article is to report the histopathological findings of the trans-operational accidental contamination with oil in the surgical area during an endodontic surgery.

  8. Accidental injuries in agriculture in the UK.

    Science.gov (United States)

    Solomon, C

    2002-12-01

    The rate of occupational accidents in British agriculture is higher than in most other industries. The most common fatal accidents are those involving vehicles and machinery, falls from a height and electrocution. A substantial proportion of reported non-fatal injuries in agricultural employees is attributable to manual handling, but among self-employed farmers the contribution is much smaller. Few data are available on longer-term determinants of risk, but accidental deaths are most frequent in July, August and September. The main approaches to preventing agricultural accidents are through engineering improvements, and education and training of the workforce. The introduction of roll-over protection structures for tractors has been an important development in recent decades. Other engineering controls include guards for power take off shafts, guard rails to prevent falls, better handling facilities for animals and closed transfer systems for pesticides. Training on safety is available from several sources, but its effectiveness in reducing accidents is uncertain.

  9. Preventing and controlling accidental gas releases

    Science.gov (United States)

    Moskowitz, P. D.; Fthenakis, V. M.; Kalb, P. D.

    1988-07-01

    Toxic, flammable, and explosive gases may be used in photovoltaic cell research laboratories and in commercial manufacturing facilities. Accidental release of these materials can present hazards to life and property. Accidents can arise from a variety of mechanical and human related failures. These can occur from the time materials are received at the loading dock of the facility to the time treated gases are discharged to the atmosphere through a stack. Each type of initiating event may require a different control approach. These may range from the training and certification of plant workers charged with the handling of gas cylinder hookups to installation of emergency pollution control systems. Since engineering options for controlling released materials are limited, emphasis should be placed on administrative and engineering approaches for preventing such accidents. These are likely to be the most effective approaches for protecting life and property.

  10. Research progress in study of accidental hypothermia

    Directory of Open Access Journals (Sweden)

    Rui YUAN

    2016-04-01

    Full Text Available Accidental hypothermia refers to a state of lowering of core body temperature down to 35 ℃induced by drowning, burial in snow and prolonged exposure to cold environment, etc. Hypothermia may affect the cardiovascular system, respiratory system, digestive system, etc. The triad consisting "hypothermia, acidosis and coagulopathy" is an important factor accelerating the death of patients. Early, timely application of rewarming measures is regarded as the basic principle in treatment of hypothermia. A series of rewarming measures, such as infusion of warm fluids, inspiration of warm air, abdominal infusion of warm fluid, instruction of warm fluid into pleural cavity, intravenous infusion of warm fluid, rewarming through ECMO, etc. have been used recently. Advance in research on the classification of hypothermia, its impact to the body and the treatment methods are reviewed in present paper. DOI: 10.11855/j.issn.0577-7402.2016.04.15

  11. Accidental Contamination with Oil during Endodontic Surgery

    Science.gov (United States)

    Plascencia, Hugo; Díaz, Mariana; Cholico, Patricia; del Real, Monserrat; Márquez-de Alba, Salvador

    2016-01-01

    The modern surgical endodontic treatment is a safe and predictable procedure with high success rate. However, several factors can retard or impede the proper healing process. Use of a high speed handpiece during hard tissues management (osteotomy and apical resection) can potentially be one of these factors. Formation of metallic debris from the surgical diamond burs, production of necrotic local tissue due to overheating and the direct liberation of air from conventional handpiece into the working area are potential irritants able to delay the tissue healing. The aim of the present article is to report the histopathological findings of the trans-operational accidental contamination with oil in the surgical area during an endodontic surgery. PMID:27790269

  12. Accidental cell phone ingestion with pharyngeal impaction.

    Science.gov (United States)

    Ali, Mohammed M; Bahl, Kazal; Dross, Matthew; Farooqui, Shoheb; Dross, Peter

    2014-09-01

    35 year old intoxicated male ingested an unusual, large foreign object (cell phone). To report the ingestion of an unusual large foreign object with hypopharyngeal impaction, complications, and treatment. Foreign body ingestion in the adult population is more prevalent in those who engage in drug or alcohol abuse. Impaction and perforation of the upper aerodigestive tract can lead to significant and potentially fatal complications including parapharyngeal/retropharyngeal abscess, mediastinitis, and aortoesophageal fistula. The treatment of foreign object ingestion is dependent on the type of foreign object ingested, its location, and potential for perforation. Endoscopic removal under general anesthesia is the treatment method recommended for foreign bodies impacted at the cricopharyngeus or esophagus. We report the only case of the accidental ingestion of an entire cell phone with casing. A plain film x-ray of the neck can be used in the assessment of the location of radiopaque foreign objects and in diagnosing potential complication.

  13. Monitoring corrosion rates and localised corrosion in low conductivity water

    DEFF Research Database (Denmark)

    Hilbert, Lisbeth Rischel

    2006-01-01

    Monitoring of low corrosion rates and localised corrosion in a media with low conductivity is a challenge. In municipal district heating, quality control may be improved by implementing on-line corrosion monitoring if a suitable technique can be identified to measure both uniform and localised...... corrosion. Electrochemical techniques (LPR, EIS, crevice corrosion current) as well as direct measurement techniques (high-sensitive electrical resistance, weight loss) have been applied in operating plants. Changes in the corrosion processes are best monitored in non-aggressive, low conductivity media...... with sensitive electrical resistance technique and crevice corrosion current measurements....

  14. Indoor Localisation Based on GSM Signals: Multistorey Building Study

    OpenAIRE

    Rafał Górak; Marcin Luckner; Michał Okulewicz; Joanna Porter-Sobieraj; Piotr Wawrzyniak

    2016-01-01

    Among the accurate indoor localisation systems that are using WiFi, Bluetooth, or infrared technologies, the ones that are based on the GSM rely on a stable external infrastructure that can be used even in an emergency. This paper presents an accurate GSM indoor localisation system that achieves a median error of 4.39 metres in horizontal coordinates and up to 64 percent accuracy in floor prediction (for 84 percent of cases the floor prediction is mistaken by not more than a single floor). Th...

  15. Hipotermia accidental secundaria a brote de psoriasis generalizada Accidental hypothermia due to generalized psoriasis

    Directory of Open Access Journals (Sweden)

    O. Agudo

    2004-04-01

    Full Text Available La hipotermia accidental es una alteración de la termorregulación corporal, definida como una temperatura central igual o inferior a 35ºC. Según la intensidad se puede clasificar en ligera (35-32,2ºC, moderada (32,2-28ºC y grave (The accidental hypothermia is a disorder of corporal termoregulation, defined as a central temperature below 35ºC. According to the intensity may be classified in mild (35-32.2 ºC, moderate (32.2-28ºC and severe (below 28ºC. The most frequent causes are the exposure to cold, use of depressant drugs of central nervous system and hypoglycemia, although there are other less frequent. We present a case of moderate hypothermia due to generalized psoriasis which required admission in the Intensive Care Unit of Hospital García Orcoyen. The termoregulation, pathogenesis, pathophysiology, diagnosis and management of accidental hypothermia are reviewed.

  16. Human SLAM, indoor localisation of devices and users

    NARCIS (Netherlands)

    Bulten, W.; Rossum, A.C. van; Haselager, W.F.G.

    2016-01-01

    The indoor localisation problem is more complex than just finding whereabouts of users. Finding positions of users relative to the devices of a smart space is even more important. Unfortunately, configuring such systems manually is a tedious process, requires expert knowledge, and is sensitive to ch

  17. Globally reasoning about localised security policies in distributed systems

    DEFF Research Database (Denmark)

    Hernandez, Alejandro Mario

    In this report, we aim at establishing proper ways for model checking the global security of distributed systems, which are designed consisting of set of localised security policies that enforce specific issues about the security expected. The systems are formally specified following a syntax, de...

  18. AUTOMATIC LICENSE PLATE LOCALISATION AND IDENTIFICATION VIA SIGNATURE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Lorita Angeline

    2014-02-01

    Full Text Available A new algorithm for license plate localisation and identification is proposed on the basis of Signature analysis. Signature analysis has been used to locate license plate candidate and its properties can be further utilised in supporting and affirming the license plate character recognition. This paper presents Signature Analysis and the improved conventional Connected Component Analysis (CCA to design an automatic license plate localisation and identification. A procedure called Euclidean Distance Transform is added to the conventional CCA in order to tackle the multiple bounding boxes that occurred. The developed algorithm, SAICCA achieved 92% successful rate, with 8% failed localisation rate due to the restrictions such as insufficient light level, clarity and license plate perceptual information. The processing time for a license plate localisation and recognition is a crucial criterion that needs to be concerned. Therefore, this paper has utilised several approaches to decrease the processing time to an optimal value. The results obtained show that the proposed system is capable to be implemented in both ideal and non-ideal environments.

  19. Application of the Localisation Platform Crowdin in Translator Education

    Science.gov (United States)

    Kudla, Dominik

    2017-01-01

    This article is an attempt to briefly describe the potential of the online localisation platform Crowdin for the education of the future translators at universities and in private courses or workshops. This description is provided on the basis of the information gathered through the user experience of the author and uses the example of the Khan…

  20. Cutting Edge Localisation in an Edge Profile Milling Head

    NARCIS (Netherlands)

    Fernandez Robles, Laura; Azzopardi, George; Alegre, Enrique; Petkov, Nicolai

    2015-01-01

    Wear evaluation of cutting tools is a key issue for prolonging their lifetime and ensuring high quality of products. In this paper, we present a method for the effective localisation of cutting edges of inserts in digital images of an edge profile milling head. We introduce a new image data set of 1

  1. Chinese Localisation of Evergreen: An Open Source Integrated Library System

    Science.gov (United States)

    Zou, Qing; Liu, Guoying

    2009-01-01

    Purpose: The purpose of this paper is to investigate various issues related to Chinese language localisation in Evergreen, an open source integrated library system (ILS). Design/methodology/approach: A Simplified Chinese version of Evergreen was implemented and tested and various issues such as encoding, indexing, searching, and sorting…

  2. El accidente de trabajo. Concepto legal y jurisprudencia

    OpenAIRE

    García Romero, José Daniel

    2015-01-01

    El trabajo final de grado versa sobre el concepto de accidente de trabajo que da la jurisprudencia a través de las diferentes sentencias del Tribunal Supremo en la Sala de lo Social, y de los diferentes Tribunales Superiores de Justicia. Analizaremos en profundidad que características tienen que concurrir para que sea considerado como tal, analizando los diferentes supuestos de accidente de trabajo como el accidente in itinere, en misión, etc. También hemos tratado las diferentes contingencia...

  3. Neuroglobin in the rat brain (II): co-localisation with neurotransmitters

    DEFF Research Database (Denmark)

    Hundahl, Christian Ansgar; Kelsen, Jesper; Dewilde, Sylvia

    2008-01-01

    -localised melanin concentration hormone (MCH). A few Ngb-ir perikarya in the paraventricular hypothalamic nucleus (PVN) co-localised arginine vasopressin (aVP). Ngb were not observed to co-localise with serotonin, vasointestinal peptide (VIP), or cocaine amphetamine-regulated transcript (CART) at any places...

  4. Quick management of accidental tritium exposure cases.

    Science.gov (United States)

    Singh, Vishwanath P; Badiger, N M; Managanvi, S S; Bhat, H R

    2012-07-01

    Removal half-life (RHL) of tritium is one of the best means for optimising medical treatment, reduction of committed effective dose (CED) and quick/easy handling of a large group of workers for medical treatment reference. The removal of tritium from the body depends on age, temperature, relative humidity and daily rainfall; so tritium removal rate, its follow-up and proper data analysis and recording are the best techniques for management of accidental acute tritium exposed cases. The decision of referring for medical treatment or medical intervention (MI) would be based on workers' tritium RHL history taken from their bodies at the facilities. The workers with tritium intake up to 1 ALI shall not be considered for medical treatment as it is a derived limit of annual total effective dose. The short-term MI may be considered for tritium intake of 1-10 ALI; however, if the results show intake ≥100 ALI, extended strong medical/therapeutic intervention may be recommended based on the severity of exposure for maximum CED reduction requirements and annual total effective dose limit. The methodology is very useful for pressurized heavy water reactors (PHWRs) which are mainly operated by Canada and India and future fusion reactor technologies. Proper management will optimise the cases for medical treatment and enhance public acceptance of nuclear fission and fusion reactor technologies.

  5. Presentismo: potencialidad en accidentes de salud

    Directory of Open Access Journals (Sweden)

    Grettchen Flores-Sandí

    2006-03-01

    Full Text Available El concepto de salud ha sobrepasado el entorno propiamente sanitario y cada vez más, tiene otras implicaciones sociales, la institución de salud es hoy en día una actividad compleja donde no solamente se gestiona la prevención y tratamiento de las enfermedades de los usuarios sino al recurso humano encargado de su atención. Asimismo en la actualidad se reconoce la importancia del recurso humano para la organización y surge el concepto de "presentismo", referido a aquellos trabajadores que sufren enfermedades que los obligarían a ausentarse del trabajo pero que se presentan a trabajar sin cumplir eficazmente sus funciones. Al respecto y en relación con el presentismo, se debe tomar en cuenta que los efectos adversos o accidentes durante la atención de servicios de salud se encuentran asociados a factores fisiológicos, psicológicos y ambientales e implican desde el punto de vista administrativo, una falla en la productividad, que afecta tanto al usuario del servicio como al trabajador. Se debe considerar que este grupo profesional se ubica entre los grupos de riesgo del presentismo y que con el fin de administrar y reducir el presentismo se requieren estrategias preventivas por parte de la gerencia de salud.

  6. The Artificial, the Accidental, the Aesthetic…

    Directory of Open Access Journals (Sweden)

    Nicole Koltick

    2015-11-01

    Full Text Available How do we define, discuss or assess aesthetics within a contemporary philosophical framework? The indefiniteness that accompanies attempts to formalize a definition of the aesthetic is a primary focus of this paper. This lack of a definition has occupied philosophers for hundreds of years in attempts to delineate the boundaries of an elusively formless concept. This formlessness speaks to the incredibly evasive character of such a pervasive feature recognized in both natural and artificial systems, agents and artefacts. With the rapid growth of artificially intelligent systems and an astounding diversity in computational creativity, in what ways may we approach aesthetics? How is the aesthetic recognized, determined and produced? This paper seeks to critically engage issues of non-human agency, inter-object relations, and aesthetic theory in relation to computational entities and autonomous systems. The ability of these systems to operate outside of human cognitive limitations including thought patterns and constructions which may preclude alternative aesthetic outcomes, afford them in some ways limitless potential in relation to aesthetics. The designation of the accidental or provisional is utilized as an alternative approach to the production and assessment of aesthetic occurrences of the non-human.

  7. Tuberculosis cutánea por inoculación accidental Cutaneous tuberculosis accidental inoculation

    Directory of Open Access Journals (Sweden)

    María Ascensión Maestre Naranjo

    2009-09-01

    Full Text Available Caso clínico de una microbióloga con amplia experiencia, que sufre una inoculación accidental al manipular una cepa pura de Mycobacterium tuberculosis. Se pincha en la cara lateral externa de la falange distal del dedo índice, atravesando el guante con la aguja contaminada. (Imagen 1. La trabajadora procede de forma inmediata a la limpieza de la herida. El Servicio de Prevención, registra la inoculación como accidente de trabajo. A las tres semanas del accidente, aparece en el lugar de la inoculación una pápula eritematosa levemente dolorosa a la presión que va creciendo hasta alcanzar un tamaño de 1,5-2 cm., sin adenopatías axilares, ni clínica general. (Imagen 2 Se procede a la exéresis y biopsia de la lesión. Informe anatomopatológico: Inflamación crónica granulomatosa tuberculoide muy sugestiva de tuberculosis cutánea. Microbiología: dudosos bacilos ácido alcohol resistentes (BAAR Cultivo: positivo a Mycobacterium tuberculosis. Ambas cepas presentan la misma identidad. Diagnóstico: tuberculosis cutánea. El SPRL realiza la comunicación de Enfermedad Profesional según el RD 1299/2006, de 10 de diciembre. Se realiza valoración y seguimiento en el Servicio de Medicina Interna, iniciando tratamiento de tuberculosis.Clinical case of a microbiologist with wide experience, which is inoculated accidental when Mycobacterium's pure strain manipulates tuberculosis; it (she pricks itself in the lateral external face of the phalanx distal of the forefinger, crossing the glove with the contaminated needle. Immediate treatment of the wound. The Service of Prevention, he registers the inoculation as accident of work. To three weeks a slightly painful pápula eritematosa appears in the place of the inoculation to the pressure that is growing until a size reaches 1,5-2 cm., without adenopatías axyllaris, not general clinic. Exéresis and biopsy of the same one, pathological anatomy: chronic inflammation very suggestive granulomatosa

  8. Epidemiology of Munchausen syndrome by proxy, non-accidental poisoning, and non-accidental suffocation.

    Science.gov (United States)

    McClure, R J; Davis, P M; Meadow, S R; Sibert, J R

    1996-07-01

    A two year prospective study was performed to determine the epidemiology of Munchausen syndrome by proxy, non-accidental poisoning, and non-accidental suffocation in the UK and the Republic of Ireland. Cases were notified to the British Paediatric Association Surveillance Unit from September 1992 to August 1994 if a formal case conference had been held for the first time during that period to discuss any of the above conditions. A total of 128 cases were identified: 55 suffered Munchausen syndrome by proxy alone, 15 poisoning, and 15 suffocation; 43 suffered more than one type of abuse. The majority of children were aged under 5 years, the median age being 20 months. On 85% of occasions the perpetrator was the child's mother. In 42% of families with more than one child, a sibling had previously suffered some form of abuse. Eighty five per cent of notifying paediatricians considered the probability of their diagnosis as virtually certain before a case conference was convened. The commonest drugs used to poison were anticonvulsants; opiates were the second commonest. Sixty eight children suffered severe illness of whom eight died. The combined annual incidence of these conditions in children aged under 16 years is at least 0.5/100,000, and for children aged under 1, at least 2.8/100,000.

  9. Snaking and isolas of localised states in bistable discrete lattices

    CERN Document Server

    Taylor, Chris; 10.1016/j.physleta.2010.10.010

    2010-01-01

    We consider localised states in a discrete bistable Allen-Cahn equation. This model equation combines bistability and local cell-to-cell coupling in the simplest possible way. The existence of stable localised states is made possible by pinning to the underlying lattice; they do not exist in the equivalent continuum equation. In particular we address the existence of 'isolas': closed curves of solutions in the bifurcation diagram. Isolas appear for some non-periodic boundary conditions in one spatial dimension but seem to appear generically in two dimensions. We point out how features of the bifurcation diagram in 1D help to explain some (unintuitive) features of the bifurcation diagram in 2D.

  10. Survival after radical prostatectomy for clinically localised prostate cancer

    DEFF Research Database (Denmark)

    Røder, Martin Andreas; Brasso, Klaus; Christensen, Ib Jarle

    2013-01-01

    hazard of all-cause and prostate cancer-specific mortality after 10 years was 15.4% (95% confide3nce interval [CI] 13.2-17.7) and 6.6% (95% CI 4.9-8.2) respectively. CONCLUSIONS: We present the first survival analysis of a complete, nationwide cohort of men undergoing RP for localised prostate cancer......OBJECTIVES: To describe survival and cause of death in a nationwide cohort of Danish patients with prostate cancer undergoing radical prostatectomy (RP). To describe risk factors associated with prostate cancer mortality. PATIENTS AND METHODS: Observational study of 6489 men with localised prostate...... cancer treated with RP at six different hospitals in Denmark between 1995 and 2011. Survival was described using Kaplan-Meier estimates. Causes of death were obtained from the national registry and cross-checked with patient files. Cumulative incidence of death, any cause and prostate cancer...

  11. Localisation of directional scale-discretised wavelets on the sphere

    CERN Document Server

    McEwen, Jason D; Wiaux, Yves

    2015-01-01

    Scale-discretised wavelets yield a directional wavelet framework on the sphere where a signal can be probed not only in scale and position but also in orientation. Furthermore, a signal can be synthesised from its wavelet coefficients exactly, in theory and practice (to machine precision). Scale-discretised wavelets are closely related to spherical needlets (both were developed independently at about the same time) but relax the axisymmetric property of needlets so that directional signal content can be probed. Needlets have been shown to satisfy important quasi-exponential localisation and asymptotic uncorrelation properties. We show that these properties also hold for directional scale-discretised wavelets on the sphere and derive similar localisation and uncorrelation bounds in both the scalar and spin settings. Scale-discretised wavelets can thus be considered as directional needlets.

  12. Large-Scale Urban Localisation with a Pushbroom LIDAR

    Science.gov (United States)

    2012-10-01

    system. The following chapter describes in depth the development of a simulator, which leverages a powerful procedural model generator to build...Levinson et. al [55],[56] is the most similar in spirit to this thesis. In terms of perception the authors make use of a 3D ranging sensor - the...as opposed to image features - to perform topological localisation within a previous traversal. In [85], the authors make use of a monocular camera as

  13. 3D laser methods for calibrating and localising robotic vehicles

    OpenAIRE

    Mark Sheehan

    2013-01-01

    This thesis is about the construction and automatic target-less calibration of a 3D laser sensor; this is then used to localise an autonomous vehicle without using other sensors. Two novel contributions to our knowledge of robotics are presented here. The first is an automatic calibration routine, which is capable of learning its calibration parameters using only data from a 3D laser scanner. Targets with known dimensions are not required, as has previously been the case. The second main ...

  14. Accidental neutron dosimetry with human hair

    Science.gov (United States)

    Ekendahl, Daniela; Bečková, Věra; Zdychová, Vlasta; Bulánek, Boris; Prouza, Zdeněk; Štefánik, Milan

    2014-11-01

    Human hair contains sulfur, which can be activated by fast neutrons. The 32S(n,p)32P reaction with a threshold of 2.5 MeV was used for fast neutron dose estimation. It is a very important parameter for individual dose reconstruction with regards to the heterogeneity of the neutron transfer to the human body. Samples of human hair were irradiated in a radial channel of a training reactor VR-1. 32P activity in hair was measured both, directly by means of a proportional counter, and as ash dispersed in a liquid scintillator. Based on neutron spectrum estimation, a relationship between the neutron dose and induced activity was derived. The experiment verified the practical feasibility of this dosimetry method in cases of criticality accidents or malevolent acts with nuclear materials.

  15. Non-accidental collision followed by dental trauma: associated factors.

    Science.gov (United States)

    Ramos-Jorge, Maria Letícia; Tataounoff, Juliana; Corrêa-Faria, Patrícia; Alcântara, Carlos Eduardo Pinto; Ramos-Jorge, Joana; Marques, Leandro Silva

    2011-12-01

    The aim of the present cross-sectional survey was to assess factors associated with non-accidental collision followed by dental trauma among adolescents in the city of Diamantina, Brazil. A total of 387 students from 12 to 15 years of age (mean = 14 SD = 0.9) were randomly selected. The study was carried out in two stages. Firstly, data were collected through dental examinations of permanent incisors. Secondly, a thorough interview was held with 85 adolescents who exhibited dental trauma in the dental examinations. The interview consisted of a detailed description of the incident and physical environment in which it occurred. Descriptive analysis and the chi-square test (P 3 mm (P = 0.007) and inadequate lip coverage (P = 0.013). Analysis of the event revealed that 22.3% of the cases of dental trauma occurred because of non-accidental collision. Non-accidental collision followed by injury occurred mainly at school (P concrete, tiled or ceramic floor (P = 0.001). No statistically significant associations were found between non-accidental collision and gender, age or mother's schooling. It was concluded that the non-accidental collisions happened especially at school and in indoor environments with a concrete, tiled or ceramic floor.

  16. Causes of accidental childhood deaths in China in 2010

    DEFF Research Database (Denmark)

    Chan, Kit Yee; Yu, Xin-Wei; Lu, Jia-Peng

    2015-01-01

    -4 years in China, of which 31 633 (10.1%) were accidental. Accidental deaths contributed 7240 (4.0%) of all deaths in neonatal period, 8838 (10.5%) among all post-neonatal infant deaths, and 15 554 (31.7%) among children with 1-4 years of age. Among four tested models, the most predictive was used......BACKGROUND: Infectious causes of childhood deaths in the world have decreased substantially in the 21st century. This trend has exposed accidental deaths as an increasingly important future challenge. Presently, little is known about the cause structure of accidental childhood deaths in low......- and middle-income country (LMIC) settings. In this paper, we aim to establish cause structure for accidental deaths in children aged 0-4 years in China in the year 2010. METHODS: In this paper, we explored the database of 208 multi-cause child mortality studies in Chinese that formed a basis for the first...

  17. A method to achieve rapid localised deep heating in a laser irradiated solid density target

    CERN Document Server

    Schmitz, Holger

    2016-01-01

    Rapid heating of small buried regions by laser generated fast electrons may be useful for applications such as XUV radiation sources or as drivers for shock experiments. In non-structured targets the heating profile possesses a global maximum near the front surface. This paper presents a new target design that uses resistive guiding to concentrate the fast electron current density at a finite depth inside the target. The choice of geometry uses principles of non-imaging optics. A global temperature maximum at depths up to 50{\\mu}m into the target is achieved. Although theoretical calculations suggest that small source sizes should perform better than large ones, simulations show that a large angular spread at high intensities results in significant losses of the fast electrons to the sides. A systematic parameter scan suggests an optimal laser intensity. A ratio of 1.6 is demonstrated between the maximum ion temperature and the ion temperature at the front surface.

  18. Plastic Collapse Localisation in Simple Shearing and Coaxial Deformations

    Science.gov (United States)

    Hobbs, B. E.; Ord, A.

    2011-12-01

    We explore, numerically, the evolution of localisation due to plastic collapse in both coaxial shortening and simple shearing deformations. These localisation features arise from plastic behaviour and hence differ from the formation of anticracks modelled by linear elastic behaviour (Fletcher and Pollard, 1990). The behaviour is close to that discussed by Rudnicki (2004) and Chemenda (2009) in that localisation consists of zones of plastic collapse separated by elastically unloaded regions. The constitutive behaviour assumed here comprises a Tresca yield with both strain-softening of the yield stress and of a cap that models plastic volumetric collapse during phase transformations, such as the olivine-spinel transition, with ΔVI., 2009. The formation of tabular compaction-band arrays: Theoretical and numerical analysis. J. Mech. Phys. Solids, 57, 851-868. Detournay, C., Cundall. P., & Parra. J. 2003. A study of compaction band formation with the double-yield model. FLAC and Numerical Modeling in Geomechanics-2003 Proceedings of the 3rd International FLAC Symposium, Sudbury, Ontario, Canada, October 2003. R. Brummer (Ed), Balkema, 27-33. Fletcher, R.C., Pollard, D.D., 1990. Anticrack model for pressure solution surfaces. Geology 9, 419- 424. Green, H.W., Burnley, P.C., 1989. A new self-organizing mechanism for deep-focus earthquakes. Nature, 341, 733- 737. Issen, K.A., Rudnicki, J.W., 2000. Conditions for compaction bands in porous rocks. J. Geophys. Res. 105, 21,529-21,536. Rudnicki, J. W. 2004. Shear and compaction band formation on an elliptic yield cap. J. Geophys. Res., 109, B03402. Veveakis, E., Alevizos, S., & Vardoulakis, I. 2010. Chemical reaction capping of thermal instabilities during shear of frictional faults. Journal of the Mechanics and Physics of Solids. 58, 1175-1194.

  19. Perfil del trauma maxilofacial en accidentes de bicicleta

    OpenAIRE

    Guadalupe Asunción Ramírez Roa; María Guadalupe Suárez-Moreno; Florentino Puerto-Álvarez; Heber Félix Quiroga-Vía; Jesús Arenas-Osuna; Bertha Vivanco-Cedeño

    2005-01-01

    Objetivo: conocer el perfil traumatológico maxilofacial, concomitante y manejo, de las personas que sufrieron accidentes de bicicleta. Se identificaron variables como edad, sexo, mecanismo, lugar, mes, patrones de lesiones, sintomatología, lapso de atención, turno, especialidad y tratamientos. Diseño: exploratorio, descriptivo, analítico, retrospectivo. Material y métodos: se censaron todos los pacientes con lesiones maxilofaciales por accidentes de bicicleta, de las notas médicas del Servici...

  20. ACCIDENTAL DEATHS DUE TO ELECTROCUTION DURING AMATEUR ELECTRO - FISHING

    Directory of Open Access Journals (Sweden)

    Ajay

    2013-11-01

    Full Text Available ABSTRACT: Electro - fishing (passing electricity through water to catch fish requires sophisticated equipment. While this method is commonly employed b y scientists for survey and fisheries management, a crude and illegal form electro - fishing is employed in Kerala for catching fish from water bodies. This can result in accidental electrocution and even fatalities. Even though they are rare, forensic patho logists in Kerala do come across such deaths from time to time. 8 cases of accidental death which occurred during electro - fishing are discussed here.

  1. Correcting for accidental correlations in saturated avalanche photodiodes

    CERN Document Server

    Grieve, James A; Tang, Zhongkan; Ling, Alexander

    2015-01-01

    In this paper we present a high-level numerical model for estimating rates of accidental correlations between a pair of passively quenched Geiger mode avalanche photodiodes operating in the saturated regime. By considering the recovery time of both the diodes and the detection circuit we introduce the concept of an "effective duty cycle" and show that it may be estimated by numeric simulation. The impact of effective duty cycle on the observed accidental rate is examined and we demonstrate that the updated model leads to an improved correction factor in actual experiments. This will improve the signal-to-noise ratio in applications depending on correlation measurements.

  2. Accidentes laborales, medicamentos y hábitos de salud

    OpenAIRE

    Esteban Martín, María Ángeles

    2015-01-01

    El presente estudio está dirigido a analizar la posible asociación con el accidente de trabajo del tipo y cantidad de medicamentos que consumen los trabajadores de forma crónica y/o aguda antes de acudir a nuestra consulta, de las enfermedades crónicas y/o agudas que padecen y de otros hábitos de consumo (alcohol y drogas). La salud laboral es un problema prioritario. El objetivo será promover la salud de los trabajadores y tratar de disminuir la incidencia de accidentes laborales. E...

  3. In silico characterisation and chromosomal localisation of human RRH (peropsin – implications for opsin evolution

    Directory of Open Access Journals (Sweden)

    Foster Russell G

    2003-01-01

    Full Text Available Abstract Background The vertebrate opsins are proteins which utilise a retinaldehyde chromophore in their photosensory or photoisomerase roles in the visual/irradiance detection cycle. The majority of the opsins, such as rod and cone opsins, have a very highly conserved gene structure suggesting a common lineage. Exceptions to this are RGR-opsin and melanopsin, whose genes have very different intron insertion positions. The gene structure of another opsin, peropsin (retinal pigment epithelium-derived rhodopsin homologue, RRH is unknown. Results By in silico analysis of the GenBank database we have determined that the human RRH comprises 7 exons spanning approximately 16.5 kb and is localised to chromosome 4q25 in the following gene sequence: cen-EGF-RRH-IF-qter – a position that excludes this gene as a candidate for the RP29 autosomal recessive retinitis pigmentosa locus. A comparison of opsin gene structures reveals that RRH and RGR share two common intron (introns 1 and 4 insertion positions which may reflect a shared ancestral gene. Conclusion The opsins comprise a diverse group of genes which appear to have arisen from three different lineages. These lineages comprise the "classical opsin superfamily" which includes the rod and cone opsins, pinopsin, VA-opsin, parapinopsin and encephalopsin; the RRH and RGR group; and the melanopsin line. A common lineage for RRH and RGR, together with their sites of expression in the RPE, indicates that peropsin may act as a retinal isomerase.

  4. Evolution of glycaemia during irradiation syndrome; Evolution de la glycemie au cours du syndrome d'irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Raisonnier, A. [Commissariat a l' Energie Atomique, Fontenay aux Roses (France). Centre d' Etudes Nucleaires

    1967-03-15

    The evolution of glycaemia following irradiation has been followed in the rat and pig. The results concerning a case of human accidental exposure have also been included. The author has tried to see whether the observed variations are reproducible and have a prognostic value. (author) [French] L'evolution de la glycemie a ete suivie, chez le rat et le porc, apres irradiation. Les resultats relatifs a une irradiation accidentelle humaine sont egalement rapportes. L'auteur cherche a definir si les variations observees sont reproductibles et ont une valeur pronostique. (auteur)

  5. Localising fast radio bursts and other transients using interferometric arrays

    CERN Document Server

    Obrocka, Monika; Wilkinson, Peter

    2015-01-01

    A new population of sources emitting fast and bright transient radio bursts has recently been identified. The observed large dispersion measure values of FRBs suggests an extragalactic origin and an accurate determination of their positions and distances will provide an unique opportunity to study the magneto-ionic properties of the IGM. So far, FRBs have all been found using large dishes equipped with multi-pixel arrays. While large single dishes are well-suited for the discovery of transient sources they are poor at providing accurate localisations. A 2D snapshot image of the sky, made with a correlation interferometer array, can provide an accurate localisation of many compact radio sources simultaneously. However, the required time resolution to detect FRBs and a desire to detect them in real time, makes this currently impractical. In a beamforming approach, where many narrow tied-array beams are produced, the advantages of single dishes and interferometers can be combined. We present a proof-of-concept a...

  6. Pattern Formation on Networks: from Localised Activity to Turing Patterns

    Science.gov (United States)

    McCullen, Nick; Wagenknecht, Thomas

    2016-06-01

    Networks of interactions between competing species are used to model many complex systems, such as in genetics, evolutionary biology or sociology and knowledge of the patterns of activity they can exhibit is important for understanding their behaviour. The emergence of patterns on complex networks with reaction-diffusion dynamics is studied here, where node dynamics interact via diffusion via the network edges. Through the application of a generalisation of dynamical systems analysis this work reveals a fundamental connection between small-scale modes of activity on networks and localised pattern formation seen throughout science, such as solitons, breathers and localised buckling. The connection between solutions with a single and small numbers of activated nodes and the fully developed system-scale patterns are investigated computationally using numerical continuation methods. These techniques are also used to help reveal a much larger portion of of the full number of solutions that exist in the system at different parameter values. The importance of network structure is also highlighted, with a key role being played by nodes with a certain so-called optimal degree, on which the interaction between the reaction kinetics and the network structure organise the behaviour of the system.

  7. An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids

    Directory of Open Access Journals (Sweden)

    Harriet Allison

    2014-10-01

    Full Text Available African trypanosomes are evolutionarily highly divergent parasitic protozoa, and as a consequence the vast majority of trypanosome membrane proteins remain uncharacterised in terms of location, trafficking or function. Here we describe a novel family of type I membrane proteins which we designate ‘invariant glycoproteins’ (IGPs. IGPs are trypanosome-restricted, with extensive, lineage-specific paralogous expansions in related taxa. In T. brucei three IGP subfamilies, IGP34, IGP40 and IGP48 are recognised; all possess a putative C-type lectin ectodomain and are ER-localised, despite lacking a classical ER-retention motif. IGPs exhibit highest expression in stumpy stage cells, suggesting roles in developmental progression, but gene silencing in mammalian infective forms suggests that each IGP subfamily is also required for normal proliferation. Detailed analysis of the IGP48 subfamily indicates a role in maintaining ER morphology, while the ER lumenal domain is necessary and sufficient for formation of both oligomeric complexes and ER retention. IGP48 is detected by antibodies from T. b. rhodesiense infected humans. We propose that the IGPs represent a trypanosomatid-specific family of ER-localised glycoproteins, with potential contributions to life cycle progression and immunity, and utilise oligomerisation as an ER retention mechanism.

  8. An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids

    Science.gov (United States)

    Allison, Harriet; O’Reilly, Amanda J.; Sternberg, Jeremy; Field, Mark C.

    2014-01-01

    African trypanosomes are evolutionarily highly divergent parasitic protozoa, and as a consequence the vast majority of trypanosome membrane proteins remain uncharacterised in terms of location, trafficking or function. Here we describe a novel family of type I membrane proteins which we designate ‘invariant glycoproteins’ (IGPs). IGPs are trypanosome-restricted, with extensive, lineage-specific paralogous expansions in related taxa. In T. brucei three IGP subfamilies, IGP34, IGP40 and IGP48 are recognised; all possess a putative C-type lectin ectodomain and are ER-localised, despite lacking a classical ER-retention motif. IGPs exhibit highest expression in stumpy stage cells, suggesting roles in developmental progression, but gene silencing in mammalian infective forms suggests that each IGP subfamily is also required for normal proliferation. Detailed analysis of the IGP48 subfamily indicates a role in maintaining ER morphology, while the ER lumenal domain is necessary and sufficient for formation of both oligomeric complexes and ER retention. IGP48 is detected by antibodies from T. b. rhodesiense infected humans. We propose that the IGPs represent a trypanosomatid-specific family of ER-localised glycoproteins, with potential contributions to life cycle progression and immunity, and utilise oligomerisation as an ER retention mechanism. PMID:26167471

  9. Probabilistic multi-person localisation and tracking in image sequences

    Science.gov (United States)

    Klinger, T.; Rottensteiner, F.; Heipke, C.

    2017-05-01

    The localisation and tracking of persons in image sequences in commonly guided by recursive filters. Especially in a multi-object tracking environment, where mutual occlusions are inherent, the predictive model is prone to drift away from the actual target position when not taking context into account. Further, if the image-based observations are imprecise, the trajectory is prone to be updated towards a wrong position. In this work we address both these problems by using a new predictive model on the basis of Gaussian Process Regression, and by using generic object detection, as well as instance-specific classification, for refined localisation. The predictive model takes into account the motion of every tracked pedestrian in the scene and the prediction is executed with respect to the velocities of neighbouring persons. In contrast to existing methods our approach uses a Dynamic Bayesian Network in which the state vector of a recursive Bayes filter, as well as the location of the tracked object in the image, are modelled as unknowns. This allows the detection to be corrected before it is incorporated into the recursive filter. Our method is evaluated on a publicly available benchmark dataset and outperforms related methods in terms of geometric precision and tracking accuracy.

  10. 3D Image Fusion to Localise Intercostal Arteries During TEVAR.

    Science.gov (United States)

    Koutouzi, G; Sandström, C; Skoog, P; Roos, H; Falkenberg, M

    2017-01-01

    Preservation of intercostal arteries during thoracic aortic procedures reduces the risk of post-operative paraparesis. The origins of the intercostal arteries are visible on pre-operative computed tomography angiography (CTA), but rarely on intra-operative angiography. The purpose of this report is to suggest an image fusion technique for intra-operative localisation of the intercostal arteries during thoracic endovascular repair (TEVAR). The ostia of the intercostal arteries are identified and manually marked with rings on the pre-operative CTA. The optimal distal landing site in the descending aorta is determined and marked, allowing enough length for an adequate seal and attachment without covering more intercostal arteries than necessary. After 3D/3D fusion of the pre-operative CTA with an intra-operative cone-beam CT (CBCT), the markings are overlaid on the live fluoroscopy screen for guidance. The accuracy of the overlay is confirmed with digital subtraction angiography (DSA) and the overlay is adjusted when needed. Stent graft deployment is guided by the markings. The initial experience of this technique in seven patients is presented. 3D image fusion was feasible in all cases. Follow-up CTA after 1 month revealed that all intercostal arteries planned for preservation, were patent. None of the patients developed signs of spinal cord ischaemia. 3D image fusion can be used to localise the intercostal arteries during TEVAR. This may preserve some intercostal arteries and reduce the risk of post-operative spinal cord ischaemia.

  11. The Accidental Transgressor: Morally-Relevant Theory of Mind

    Science.gov (United States)

    Killen, Melanie; Mulvey, Kelly Lynn; Richardson, Cameron; Jampol, Noah; Woodward, Amanda

    2011-01-01

    To test young children's false belief theory of mind in a morally relevant context, two experiments were conducted. In Experiment 1, children (N=162) at 3.5, 5.5, and 7.5 years of age were administered three tasks: prototypic moral transgression task, false belief theory of mind task (ToM), and an "accidental transgressor" task, which measured a…

  12. The Accidental Transgressor: Morally Relevant Theory of Mind

    Science.gov (United States)

    Killen, Melanie; Mulvey, Kelly Lynn; Richardson, Cameron; Jampol, Noah

    2014-01-01

    To test young children’s false belief theory of mind in a morally relevant context, two experiments were conducted. In Experiment 1, children (N = 162) at 3.5, 5.5, and 7.5 years of age were administered 3 tasks: prototypic moral transgression task, false belief theory of mind task (ToM), and an “accidental transgressor” task, which measured a morally relevant false belief theory of mind (MoToM). Children who did not pass false belief ToM were more likely to attribute negative intentions to an accidental transgressor than children who passed false belief ToM, and to use moral reasons when blaming the accidental transgressor. In Experiment 2, children (N = 46) who did not pass false belief ToM viewed it as more acceptable to punish the accidental transgressor than did participants who passed false belief ToM. Findings are discussed in light of research on the emergence of moral judgment and theory of mind. PMID:21377148

  13. The Accidental Transgressor: Morally-Relevant Theory of Mind

    Science.gov (United States)

    Killen, Melanie; Mulvey, Kelly Lynn; Richardson, Cameron; Jampol, Noah; Woodward, Amanda

    2011-01-01

    To test young children's false belief theory of mind in a morally relevant context, two experiments were conducted. In Experiment 1, children (N=162) at 3.5, 5.5, and 7.5 years of age were administered three tasks: prototypic moral transgression task, false belief theory of mind task (ToM), and an "accidental transgressor" task, which measured a…

  14. Quality control for handling of accidental blood exposures.

    NARCIS (Netherlands)

    Wijk, P.T. van; Pelk-Jongen, M.; Wijkmans, C.; Voss, A.; Schneeberger, P.M.

    2006-01-01

    A regional counselling service was established to handle all accidental blood exposures using a standardized protocol. Levels of risk were assessed using an algorithm. Accidents that posed a risk for the transmission of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) were

  15. 49 CFR 192.751 - Prevention of accidental ignition.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Prevention of accidental ignition. 192.751 Section 192.751 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.751 Prevention...

  16. Quality control for handling of accidental blood exposures.

    NARCIS (Netherlands)

    Wijk, P.T. van; Pelk-Jongen, M.; Wijkmans, C.; Voss, A.; Schneeberger, P.M.

    2006-01-01

    A regional counselling service was established to handle all accidental blood exposures using a standardized protocol. Levels of risk were assessed using an algorithm. Accidents that posed a risk for the transmission of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) were

  17. An accidental sect: how war made belief in Sierra Leone

    NARCIS (Netherlands)

    Richards, P.

    2006-01-01

    Idealists consider beliefs cause wars. Realists consider wars cause beliefs. The war in Sierra Leone offers some scope to test between these two views. The main rebel faction, the Revolutionary United Front (RUF) was, sociologically speaking, an accidental sect. It lost its original ideologues at an

  18. Irradiation damage

    Energy Technology Data Exchange (ETDEWEB)

    Howe, L.M

    2000-07-01

    There is considerable interest in irradiation effects in intermetallic compounds from both the applied and fundamental aspects. Initially, this interest was associated mainly with nuclear reactor programs but it now extends to the fields of ion-beam modification of metals, behaviour of amorphous materials, ion-beam processing of electronic materials, and ion-beam simulations of various kinds. The field of irradiation damage in intermetallic compounds is rapidly expanding, and no attempt will be made in this chapter to cover all of the various aspects. Instead, attention will be focused on some specific areas and, hopefully, through these, some insight will be given into the physical processes involved, the present state of our knowledge, and the challenge of obtaining more comprehensive understanding in the future. The specific areas that will be covered are: point defects in intermetallic compounds; irradiation-enhanced ordering and irradiation-induced disordering of ordered alloys; irradiation-induced amorphization.

  19. Responsabilidad del empleador por accidentes de trabajo y enfermedades profesionales

    Directory of Open Access Journals (Sweden)

    Cristina Mangarelli

    2014-01-01

    Full Text Available Introducción. 1. Responsabilidad del “empleador” por accidentes de trabajo y enfermedades profesionales. Noción. 2. La indemnización “tarifada”. Fundamento de su procedencia 3. Responsabilidad del empleador por accidentes de trabajo o enfermedades profesionales en la ley uruguaya (ley Nº 16.074. 4. La “ampliación” de la responsabilidad del empleador por el derecho común en el derecho uruguayo (artículo 7 ley Nº 16.074. 5. Requisitos para la ampliación de la responsabilidad patronal: culpa grave en el incumplimientode normas de seguridad y prevención. 6. La culpa grave. Concepto. 7. El modelo del hombre a tener en cuenta en la “culpa grave” no es el del buen padre de familia. 8. El grado de la culpa no puede ser medido por el resultado del accidente. 9. Se aplican las eximentes de la responsabilidad civil. 10. Distintos ámbitos de la responsabilidad patronal por accidentes de trabajo o enfermedades profesionales: A ante la víctima o los derecho-habientes; B ante el Banco de Seguros del Estado; C ante el Ministerio de Trabajo ySeguridad Social. 11. Recupero del BSE en caso de culpa grave en el incumplimiento de normas de seguridad y prevención. Requisitos 12. Responsabilidad del empleador en caso de accidente de trabajo o enfermedad profesional sufrido por un adolescente. Conclusiones.

  20. Newspaper: Files. Radiotherapy and accidental radiation protection. Scientific management between I.G.R. and I.P.S.N; Presse dossiers. Radiotherapie et radioprotection accidentelle. Partenariat scientifique entre l'IGR et l'IPSN

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    The Gustave-Roussy Institute (I.G.R.), the biggest european center of cancer treatment, and the Institute of Protection and Nuclear Safety (I.P.S.N.) that lead important researches and expertise in accidental radiation protection have established an agreement for a research program for six years. The objective is to speed up the researches in radio-pathology and radiobiology to improve the techniques used to treat the irradiated persons, for therapeutic or accidental reasons. Three principal themes have been chosen as starting point: Diagnosis and prognosis bio-indicators of irradiation effects on the digestive system, biological dosimetry and long term effects of a high dose irradiation. New themes will be tackled in function of the results or new needs. (N.C.)

  1. Source localisation and dose verification for a novel brachytherapy unit

    Science.gov (United States)

    Metaxas, Marinos G.

    A recent development in the field of radiotherapy has been the introduction of the PRS Intrabeam system (Carl Zeiss Surgical GmbH, Oberkochen, Germany). This is essentially a portable, miniaturised, electron-driven photon generator that allows high intensity, soft-energy x-rays (50 kVp) to be delivered directly to the tumour site in a single fraction. The system has been used for the interstitial radiation treatment of both brain and breast tumours. At present, a standardised in-vivo dose verification technique is not available for the PRS treatments. The isotropical distribution of photons about the tip of the PRS probe inserted in the tissue can effectively be viewed as a point source of radiation buried in the body. This work has looked into ways of localising the PRS source utilising its own radiation field. Moreover, the response of monoenergetic sources, mimicking realistic brachytherapy sources, has also been investigated. The purpose of this project was to attempt to localise the source as well as derive important dosimetric information from the resulting image. A detection system comprised of a well-collimated Germanium detector (HPGe) has been devised in a rotate-translate Emission Computed Tomography (ECT) modality. The superior energy resolving ability of the detection system allowed for energy selective reconstruction to be carried out in the case of the monoenergetic source (241Am). Results showed that the monoenergetic source can be localised to within 1 mm and the continuous PRS x-ray source to within 3mm. For the PRS dose map derivation, Monte Carlo studies have been employed in order to extract information on the dosimetric aspect of the resulting image. The final goal of this work was therefore to formulate a direct mathematical relation (Transform Map) between the image created by the escaping photons and the dose map as predicted by the theoretical model. The formation therefore of the in-vivo PRS image could allow for a real-time monitoring

  2. The importance of strain localisation in shear zones

    Science.gov (United States)

    Bons, Paul D.; Finch, Melanie; Gomez-Rivas, Enrique; Griera, Albert; Llorens, Maria-Gema; Steinbach, Florian; Weikusat, Ilka

    2016-04-01

    The occurrence of various types of shear bands (C, C', C'') in shear zones indicate that heterogeneity of strain is common in strongly deformed rocks. However, the importance of strain localisation is difficult to ascertain if suitable strain markers are lacking, which is usually the case. Numerical modelling with the finite-element method has so far not given much insight in the development of shear bands. We suggest that this is not only because the modelled strains are often not high enough, but also because this technique (that usually assumes isotropic material properties within elements) does not properly incorporate mineral deformation behaviour. We simulated high-strain, simple-shear deformation in single- and polyphase materials with a full-field theory (FFT) model coupled to the Elle modelling platform (www.elle.ws; Lebensohn 2001; Bons et al. 2008). The FFT-approach simulates visco-plastic deformation by dislocation glide, taking into account the different available slip systems and their critical resolved shear stresses in relations to the applied stresses. Griera et al. (2011; 2013) have shown that this approach is particularly well suited for strongly anisotropic minerals, such as mica and ice Ih (Llorens 2015). We modelled single- and polyphase composites of minerals with different anisotropies and strengths, roughly equivalent to minerals such as ice Ih, mica, quartz and feldspar. Single-phase polycrystalline aggregates show distinct heterogeneity of strain rate, especially in case of ice Ih, which is mechanically close to mica (see also Griera et al. 2015). Finite strain distributions are heterogeneous as well, but the patterns may differ from that of the strain rate distribution. Dynamic recrystallisation, however, usually masks any strain and strain rate localisation (Llorens 2015). In case of polyphase aggregates, equivalent to e.g. a granite, we observe extensive localisation in both syn- and antithetic shear bands. The antithetic shear bands

  3. Evaluating ALWadHA for providing secure localisation for wireless sensor networks

    CSIR Research Space (South Africa)

    Abu-Mahfouz, Adnan M

    2013-09-01

    Full Text Available secure localisation algorithms that are able to work in a hostile environment. An attacker could compromise, or masquerade as, a beacon node and send incorrect location information. Localisation in a hostile environment is a critical problem in wireless...

  4. Optimal placement of range-only beacons for mobile robot localisation

    CSIR Research Space (South Africa)

    Burke, Michael G

    2011-11-01

    Full Text Available The ability of an agent to self-localise is crucial to any autonomous task where mobility is required. A common set of techniques solving the localisation problem involve the deployment of active beacons or landmarks, which eliminate problems...

  5. Binaural Active Audition for Humanoid Robots to Localise Speech over Entire Azimuth Range

    Directory of Open Access Journals (Sweden)

    Hyun-Don Kim

    2009-01-01

    Full Text Available We applied motion theory to robot audition to improve the inadequate performance. Motions are critical for overcoming the ambiguity and sparseness of information obtained by two microphones. To realise this, we first designed a sound source localisation system integrated with cross-power spectrum phase (CSP analysis and an EM algorithm. The CSP of sound signals obtained with only two microphones was used to localise the sound source without having to measure impulse response data. The expectation-maximisation (EM algorithm helped the system to cope with several moving sound sources and reduce localisation errors. We then proposed a way of constructing a database for moving sounds to evaluate binaural sound source localisation. We evaluated our sound localisation method using artificial moving sounds and confirmed that it could effectively localise moving sounds slower than 1.125 rad/s. Consequently, we solved the problem of distinguishing whether sounds were coming from the front or rear by rotating and/or tipping the robot's head that was equipped with only two microphones. Our system was applied to a humanoid robot called SIG2, and we confirmed its ability to localise sounds over the entire azimuth range as the success rates for sound localisation in the front and rear areas were 97.6% and 75.6% respectively.

  6. Underwater Acoustic Source Localisation Among Blind and Sighted Scuba Divers: Comparative study

    Directory of Open Access Journals (Sweden)

    Jacopo Cambi

    2017-06-01

    Full Text Available Objectives: Many blind individuals demonstrate enhanced auditory spatial discrimination or localisation of sound sources in comparison to sighted subjects. However, this hypothesis has not yet been confirmed with regards to underwater spatial localisation. This study therefore aimed to investigate underwater acoustic source localisation among blind and sighted scuba divers. Methods: This study took place between February and June 2015 in Elba, Italy, and involved two experimental groups of divers with either acquired (n = 20 or congenital (n = 10 blindness and a control group of 30 sighted divers. Each subject took part in five attempts at an under-water acoustic source localisation task, in which the divers were requested to swim to the source of a sound originating from one of 24 potential locations. The control group had their sight obscured during the task. Results: The congenitally blind divers demonstrated significantly better underwater sound localisation compared to the control group or those with acquired blindness (P = 0.0007. In addition, there was a significant correlation between years of blindness and underwater sound localisation (P <0.0001. Conclusion: Congenital blindness was found to positively affect the ability of a diver to recognise the source of a sound in an underwater environment. As the correct localisation of sounds underwater may help individuals to avoid imminent danger, divers should perform sound localisation tests during training sessions.

  7. A size-dependent constitutive modelling framework for localised failure analysis

    Science.gov (United States)

    Nguyen, Giang D.; Nguyen, Chi T.; Nguyen, Vinh P.; Bui, Ha H.; Shen, Luming

    2016-08-01

    Localised deformation of materials usually takes place in thin bands during the nonlinear phase of the deformation process. The orientation and size of these localisation bands are important properties characterising the post-localisation behaviour of the materials, and hence should be taken into account in constitutive modelling. In this research, a new approach is proposed for the integration of both size and orientation of a localisation band in the constitutive description beyond the onset of localisation. Since a length scale related to the size of the localisation band appears in the model description, its post-localisation response then scales with both the band size and the size of the volume element containing it. Therefore, size effects are intrinsically included and post-localisation behaviour is correctly captured, which helps ensure convergence of numerical solutions upon discretisation refinement in numerical analysis of boundary value problems. The concept together with implementation features of the framework and its performances at constitutive level and in the analysis of boundary value problems are presented in this paper.

  8. 21 CFR 369.9 - General warnings re accidental ingestion by children.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false General warnings re accidental ingestion by... OVER-THE-COUNTER SALE Definitions and Interpretations § 369.9 General warnings re accidental ingestion... possibility of accidental ingestion of drugs, it is not only suggested but is recommended that one of these...

  9. Active surveillance strategy for patients with localised prostate cancer

    DEFF Research Database (Denmark)

    Thomsen, Frederik Birkebæk

    2014-01-01

    BACKGROUND: Active surveillance - an initial observational strategy - offers a tailored management of patients with localised prostate cancer. The aim of the strategy is to appoint patients with potentially lethal prostate cancer to curatively intended treatment, while patients with slowly evolving...... resulted in a significant risk of being misclassified according to the definition of progression. The interobserver agreement of biopsy histopathology between expert uropathologist was substantial. Still, the pathologists' disagreement would have resulted in different treatment recommendations in up to 10...... with defined final histopathological findings at radical prostatectomy that was perceived as unacceptable for a continued observational strategy. CONCLUSION: The thesis has demonstrated that active surveillance is feasible and reduces the number of patients undergoing curative intended treatment. However...

  10. Influence of localised double suction on a turbulent boundary layer

    Science.gov (United States)

    Oyewola, O.; Djenidi, L.; Antonia, R. A.

    2007-07-01

    The effects of localised suction applied through a pair of porous wall strips on a turbulent boundary layer have been quantified through the measurements of mean velocity and Reynolds stresses. The results indicate that the use of second strip extends the pseudo-relaminarisation zone but also reduces the overshoot in the longitudinal and normal r.m.s. velocities. While the minimum r.m.s. occurs at x/δo=3.0 (one strip) and x/δo=12 (two strips), the reduction observed for the latter case is larger. Relative to no suction, the turbulence level is modified by suction and the effect is enhanced with double suction. This increased effectiveness reflects the fact that the second strip acts on a boundary layer whose near-wall active motion has been seriously weakened by the first strip.

  11. Law of Localised Fine Structure with application in mass spectrometry

    CERN Document Server

    Łącki, Mateusz Krzysztof

    2014-01-01

    This paper presents a brand new methodology to deal with isotopic fine structure calculations. By using the Poisson approximation in an entirely novel way, we introduce mathematical elegance into the discussion on the trade-off between resolution and tractability. Our considerations unify the concepts of fine-structure, equatransneutronic configurations, and aggregate isotopic structure in a natural and simple way. We show how to boost the theoretical resolution in a seemingly costless way by several orders of magnitude with respect to the already very efficient algorithms operating on isotopic aggregates. We also develop an effective new way to obtain the important peaks in the most disaggregated isotopic structure localised in a precise region in the mass domain.

  12. Le kyste hydatique du cordon spermatique : une localisation exceptionnelle

    Directory of Open Access Journals (Sweden)

    Mohamed Moncef Hamdane

    2011-12-01

    Full Text Available L� hydatidose est une anthropozoonose due au developpement chez l�homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extremement rare avec seulement 4 cas rapportes dans la litterature. Les auteurs rapportent dans cet article un nouveau cas d�hydatidose du cordon spermatique. Il s�agissait d�un homme de 40 ans qui consultait pour des douleurs scrotales evoluant depuis huit mois. L�examen clinique a mis en evidence une tumefaction mobile, inguino-scrotale, droite. L�echographie testiculaire a objective une hernie inguinale droite associee a deux kystes epididymaires bilateraux. Le patient a ete opere pour cure de son hernie avec decouverte en per-operatoire d�un kyste du cordon spermatique qui a ete reseque. L�examen anatomopathologique a conclu a une hydatidose du cordon spermatique.

  13. Østebø, Terje. — Localising Salafism

    OpenAIRE

    Vezzadini, Elena

    2012-01-01

    Localising Salafism est une étude approfondie sur l’origine et le développement du salafisme dans le Bale, une province au sud-est de l’Éthiopie, habitée majoritairement par les Oromo qui y constituent environ 90 % de la population. il s’agit aussi d’une région à grande majorité musulmane (92 %), qui fait partie des neuf divisions administratives de l’Éthiopie, connue comme Oromiyaa. L’auteur travaille donc sur une région très peu étudiée, et sur un sujet, l’islam en Éthiopie, encore marginal...

  14. Localised structures in 2D Kolmogorov flow in large domains: Kinks, Snakes and 'Kolmotons'

    CERN Document Server

    Lucas, Dan

    2013-01-01

    Kolmogorov flow in two dimensions - the 2D Navier-Stokes equations with a sinusoidal body force - is considered over extended periodic domains to reveal localised spatiotemporal complexity. The flow response mimicks the forcing at small forcing amplitudes but beyond a critical value, the vorticity of the flow localises into `kink' structures. These kinks act as building blocks for multiple localised attractors which emerge as the forcing further intensifies. Most notable of these is a temporally-periodic state which consists of two intertwined and wiggling kinks (resembling a snake) bordered by two steady chaperoning kinks. As the forcing is increased, this `snake' experiences a period doubling cascade to spatially-localised chaos before becoming a localised chaotic repeller through a boundary crisis. Further interesting dynamics arise when these kink and snake structures are confronted with each other. The most eye-catching example of this is the `particle-like' interaction of propagating kinks (christened `...

  15. Localisation and mechanism of renal retention of radiolabelled somatostatin analogues

    Energy Technology Data Exchange (ETDEWEB)

    Melis, Marleen; Krenning, Eric P.; Bernard, Bert F.; Jong, Marion de [Erasmus MC, Department of Nuclear Medicine, Rotterdam (Netherlands); Barone, Raffaella [UCL, Centre of Nuclear Medicine and Laboratory of PET, Brussels (Belgium); Visser, Theo J. [Erasmus MC, Department of Internal Medicine, Rotterdam (Netherlands)

    2005-10-01

    Radiolabelled somatostatin analogues, such as octreotide and octreotate, are used for tumour scintigraphy and radionuclide therapy. The kidney is the most important critical organ during such therapy owing to the reabsorption and retention of radiolabelled peptides. The aim of this study was to investigate in a rat model both the localisation and the mechanism of renal uptake after intravenous injection of radiolabelled somatostatin analogues. The multi-ligand megalin/cubilin receptor complex, responsible for reabsorption of many peptides and proteins in the kidney, is an interesting candidate for renal endocytosis of these peptide analogues. For localisation studies, ex vivo autoradiography and micro-autoradiography of rat kidneys were performed 1-24 h after injection of radiolabelled somatostatin analogues and compared with the renal anti-megalin immunohistochemical staining pattern. To confirm a role of megalin in the mechanism of renal retention of [{sup 111}In-DTPA]octreotide, the effects of three inhibitory substances were explored in rats. Renal ex vivo autoradiography showed high cortical radioactivity and lower radioactivity in the outer medulla. The distribution of cortical radioactivity was inhomogeneous. Micro-autoradiography indicated that radioactivity was only retained in the proximal tubules. The anti-megalin immunohistochemical staining pattern showed a strong similarity with the renal [{sup 111}In-DTPA]octreotide ex vivo autoradiograms. Biodistribution studies showed that co-injection of positively charged d-lysine reduced renal uptake to 60% of control. Sodium maleate reduced renal [{sup 111}In-DTPA]octreotide uptake to 15% of control. Finally, cisplatin pre-treatment of rats reduced kidney uptake to 70% of control. Renal retention of [{sup 111}In-DTPA]octreotide is confined to proximal tubules in the rat kidney, in which megalin-mediated endocytosis may play an important part. (orig.)

  16. Study of the degradations caused by nuclear accidental conditions on a steel coating

    Energy Technology Data Exchange (ETDEWEB)

    Ayrinhac, F.; Terriol, J.M. [EDF Ceidre TEGG (France)

    2011-07-01

    The coatings used in nuclear power plants have an interest to make surfaces easily decontaminated and to protect carbon steel (liner and steelworks) from the corrosion. However, in the event of accidental conditions, in particular combining radiation and fast increase of temperature and pressure, these paintings must not constitute an uncontrolled source of debris which may block the safety related functions of core cooling. This experimental study reports the influence of thickness and colour of the withstanding of a steel coating during accidental conditions. The steel coating chosen has been qualified for the liner containment of EDF new generation nuclear power plants (EPR). According to its data sheet, it is composed of an anti-corrosion primer (45 {mu}m), of an intermediate coat (same nature than the primer, 45 {mu}m) and a top coat (50 {mu}m). The system, applied using an conventional spray, was studied by optical and electronic microscopy. After gun airless application and drying, steel samples underwent an irradiation test, a LOCA test followed by a post-accident (100 C an d 100% HR during 10 days). Microscopic analysis by SEM and optical microscopy were carried out in order to evaluate and compare degradations of samples. In conclusion, whatever the color chosen or the thickness obtained, the primers and second coat ('internal layer') do not undergo significant evolution during the test. The greatest part of degradations is inflicted on the top coat. These degradations take the form of vacuums of two types, micro-porosity (few microns diameter) and surface blisters connected with internal spherical vacuums of size ranging between 8 and 50 {mu}m

  17. Food irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Webb, T.

    1986-01-01

    The proposed use of gamma radiation from cobalt 60 and cesium 137 for food irradiation in the United Kingdom is discussed, with particular reference to the possible dangers and disadvantages to the safety and wholesomeness of the food.

  18. El accidente de trabajo "in itinere" = Working in the accident "itinere"

    OpenAIRE

    Pinillas Carro, Pedro

    2015-01-01

    El trabajo aqu?? presentado aborda el estudio de los accidentes de trabajo, regulado al art??culo 115 Ley General de Seguridad Social, y m??s concretamente el accidente in itinere, claro est??, sin olvidar tampoco el accidente en misi??n. En la primera parte del trabajo, y una vez desarrollado el concepto de accidente de trabajo, el presente trabajo se centra en el estudio pormenorizado del accidente in itinere y sus requisitos (teleol??gico, topogr??fico, cronol??gico y mec??nico). Por otro ...

  19. [Food irradiation].

    Science.gov (United States)

    Migdał, W

    1995-01-01

    A worldwide standard on food irradiation was adopted in 1983 by Codex Alimentarius Commission of the Joint Food Standard Programme of the Food and Agriculture Organization (FAO) of the United Nations and the World Health Organization (WHO). As a result, 41 countries have approved the use of irradiation for treating one or more food items and the number is increasing. Generally, irradiation is used to: food loses, food spoilage, disinfestation, safety and hygiene. The number of countries which use irradiation for processing food for commercial purposes has been increasing steadily from 19 in 1987 to 33 today. In the frames of the national programme on the application of irradiation for food preservation and hygienization an experimental plant for electron beam processing has been established in Institute of Nuclear Chemistry and Technology. The plant is equipped with a small research accelerator Pilot (19MeV, 1 kW) and an industrial unit Elektronika (10MeV, 10 kW). On the basis of the research there were performed at different scientific institutions in Poland, health authorities have issued permission for irradiation for: spices, garlic, onions, mushrooms, potatoes, dry mushrooms and vegetables.

  20. Leading global projects for professional and accidental project leaders

    CERN Document Server

    Moran, Robert T

    2008-01-01

    This book is a must-read for anyone responsible for projects and initiatives that span functional and geographical divides. Authors Moran and Youngdahl bring extensive experience and learning from industry practice to present a clear and straightforward treatment of the leadership skills and knowledge required to lead projects that are global in nature. They have written the first book of its kind to address the three essential skills of global project leaders - strategic project management, project leadership, and cross-cultural leadership. The authors argue that global project leadership is an essential skill in our project-based world and that we are all either intentional or accidental project leaders. Intentional project leaders pursue formal project management education and even certification whereas accidental project leaders find themselves leading global projects and initiatives as a result of a special assignment or promotion. Moran and Youndahl have found that the vast majority of global projects ...

  1. Accidental degeneracy of double Dirac cones in a phononic crystal

    KAUST Repository

    Chen, Ze-Guo

    2014-04-09

    Artificial honeycomb lattices with Dirac cone dispersion provide a macroscopic platform to study the massless Dirac quasiparticles and their novel geometric phases. In this paper, a quadruple-degenerate state is achieved at the center of the Brillouin zone in a two-dimensional honeycomb lattice phononic crystal, which is a result of accidental degeneracy of two double-degenerate states. In the vicinity of the quadruple-degenerate state, the dispersion relation is linear. Such quadruple degeneracy is analyzed by rigorous representation theory of groups. Using method, a reduced Hamiltonian is obtained to describe the linear Dirac dispersion relations of this quadruple-degenerate state, which is well consistent with the simulation results. Near such accidental degeneracy, we observe some unique properties in wave propagating, such as defect-insensitive propagating character and the Talbot effect.

  2. Accidental Electric Shock during Pregnancy: Reflection on a Case

    Directory of Open Access Journals (Sweden)

    Johnny Awwad

    2013-10-01

    Full Text Available Objectives - Data on fetal effects following accidental electric shock during pregnancy are scarce. We report on a case of accidental maternal electric shock associated with benign fetal arrhythmia in a woman at 28 weeks' gestation. Study Design - Case report. Results - Although electrocution involving low-voltage, low-frequency current has been associated with fatal cardiac arrhythmias and conduction abnormalities, two protective parameters in the present case likely reduced the fetal injury: the dry skin at the site of current entry and the hand-to-hand pathway of current flow. Conclusion - Because the pathophysiology of electric injury is altered during pregnancy, assessment of fetal well-being should be prompted no matter how trivial an incident may appear.

  3. Accidental Electric Shock during Pregnancy: Reflection on a Case.

    Science.gov (United States)

    Awwad, Johnny; Hannoun, Antoine; Fares, Farah; Ghazeeri, Ghina

    2013-10-01

    Objectives Data on fetal effects following accidental electric shock during pregnancy are scarce. We report on a case of accidental maternal electric shock associated with benign fetal arrhythmia in a woman at 28 weeks' gestation. Study Design Case report. Results Although electrocution involving low-voltage, low-frequency current has been associated with fatal cardiac arrhythmias and conduction abnormalities, two protective parameters in the present case likely reduced the fetal injury: the dry skin at the site of current entry and the hand-to-hand pathway of current flow. Conclusion Because the pathophysiology of electric injury is altered during pregnancy, assessment of fetal well-being should be prompted no matter how trivial an incident may appear.

  4. Food allergy: practical approach on education and accidental exposure prevention.

    Science.gov (United States)

    Pádua, I; Moreira, A; Moreira, P; Barros, R

    2016-09-01

    Food allergies are a growing problem and currently the primary treatment of food allergy is avoidance of culprit foods. However, given the lack of information and education and also the ubiquitous nature of allergens, accidental exposures to food allergens are not uncommon. The fear of potential fatal reactions and the need of a proper avoidance leads in most of the cases to the limitation of leisure and social activities. This review aims to be a practical approach on education and accidental exposure prevention regarding activities like shopping, eating out, and travelling. The recommendations are focused especially on proper reading of food labels and the management of the disease, namely in restaurants and airplanes, concerning cross-contact and communication with other stakeholders. The implementation of effective tools is essential to manage food allergy outside home, avoid serious allergic reactions and minimize the disease's impact on individuals' quality of life.

  5. D-transallethrin: An unusual agent for accidental poisoning

    OpenAIRE

    Vinod Kedari; Rajesh Kulkarni; Chhaya Valvi; Aarti Kinikar; Sandhya Khadse

    2016-01-01

    D-trans allethrin, a pyrethroid, is commonly used as a coil mosquito repellant. There are very few reports of human toxicity due to D-trans allethrin. We present the case of an 11-month-old boy who presented to us with excessive salivation, altered sensorium and convulsions following alleged accidental ingestion of a coil containing D-transallethrin. He required mechanical ventilation for a brief period and made a full recovery. Although rare, the possibility of pyrethroid poisoning should be...

  6. Accidental surface contamination - The effect on trace element analysis

    Energy Technology Data Exchange (ETDEWEB)

    Franklyn, C.B. E-mail: franklyn@aec.co.za; Ueckermann, H.; Merkle, R.K.W

    2001-07-01

    We discuss the accidental contamination of samples during a micro-PIXE study of Rh, Pd and Pt partition coefficients in the Fe-S and Ni-S systems. Trace amounts of Ni and Cu, mounted separately in epoxy as markers, were found to be present in various phases in the sections, sometimes selectively in specific mineral phases. This contamination is believed to result from polishing during preparation. Further surface contamination from conductive Ag paste was also observed.

  7. Accidental IV administration of epinephrine instead of midazolam at colonoscopy

    Directory of Open Access Journals (Sweden)

    Ahmed Gado

    2016-03-01

    Full Text Available Drug administration errors appear to be a major source of iatrogenic harm to hospitalized patients. They often, particularly in the case of epinephrine, have catastrophic consequences both for the patient and the well-meaning provider. The following incident is a medication error case report which illustrates one way that incorrect medication may be administered. IV epinephrine was accidentally administered instead of midazolam at colonoscopy.

  8. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application

    OpenAIRE

    Michael Froehle; Haas, Nikolaus A.; Guenther Kirchner; Deniz Kececioglu; Eugen Sandica

    2012-01-01

    Mepivacaine is a potent local anaesthetic and used for infiltration and regional anaesthesia in adults and pediatric patients. Intoxications with mepivacaine affect mainly the CNS and the cardiovascular system. We present a case of accidental intravenous mepivacaine application and intoxication of an infant resulting in seizure, broad complex bradyarrhythmia, arterial hypotension and finally cardiac arrest. The patient could be rescued by prolonged resuscitations and a rapid initiation of ECM...

  9. La prevención de accidentes (3

    Directory of Open Access Journals (Sweden)

    Chinchilla, M.

    1966-04-01

    Full Text Available The financial loss due to working accidents is very substantial, quite apart from the actual loss of human lives. Hence avoiding these accidents is a most important matter. The accident index in the various industries shows a rate of increase that is larger than should be the case in proportion to the development of the industries concerned, and the larger number of employees. The fact that these indexes are smaller in many countries, however, shows that these accidents can be considerably reduced if suitable measures are taken to avoid them. In chapter 2 of our magazine, issue no. 178, a variety of reasons were discussed that may originate accidents, although these causes are not directly linked to the accident itself. In this article mention is made of some of the measures that can be taken in the handling of cutting and welding equipment, and also of inflammable liquids, to prevent possible accidents.El peso de los accidentes de trabajo sobre la economía supone cantidades muy grandes que, independientemente del inestimable valor de una vida humana, realzan la importancia de la prevención de accidentes. Los índices de accidentes muestran en diferentes industrias un crecimiento mayor de lo que debería corresponder proporcionalmente, habida cuenta del crecimiento laboral. El hecho de que en distintos países los índices sean inferiores, demuestra que se pueden conseguir buenos frutos si se concede primordial importancia a que los trabajos se realicen con las debidas medidas de seguridad. En el Capítulo 2, número 178 de esta Revista, se detallaron diversas causas que pueden originar un accidente sin estar ligadas en forma directa con una tarea determinada. En el presente trabajo se indican algunas de las medidas que deben observarse en el manejo de los equipos de soldadura y corte, así como en el transvase de líquidos inflamables.

  10. Assessment of evolutive and prognostic indicators applied to accidental overexposure to ionizing radiation; Evaluacion de indicadores pronosticos y evolutivos aplicables a situaciones accidentales de sobreexposicion a radiaciones ionizantes

    Energy Technology Data Exchange (ETDEWEB)

    Morera Carrillo, M. de Lourdes; Cardenas, J. [Centro de Proteccion y Higiene de las Radiaciones, La Habana (Cuba); Dubner, D.; Perez, M. del Rosario; Gisone, P. [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina). Lab. de Radiopatologia; Carnot, J. [Hospital Clinico Quirurgico Hermanos Ameijeiras, La Habana (Cuba)

    2001-07-01

    The acute radiation syndrome has been characterized in different ways that involve risk for life and health of the people overexposed to ionizing radiations. This work intends to test a therapeutical total body irradiation (TBI) model as conditioning to bone marrow transplantation. With the purpose of evaluating the applicability of several biological indicators in accidental overexposures, a study was carried out in 46 patients undergoing TBI receiving doses between 10 Gy and 12 Gy. The following parameters were assessed: lipo peroxyde plasmatic levels (TBARS) and total plasma antioxidant activity, reticulocyte maturity index (RMI) and charges in lymphocyte subpopulations. These data suggest that TBARS could provide an useful evolutive indicator in accidental overexposed patients and RMI is an early indicator of bone marrow recovery after radioinduced aplasia.

  11. "Dead in hot bathtub" phenomenon: accidental drowning or natural disease?

    Science.gov (United States)

    Satoh, Fumiko; Osawa, Motoki; Hasegawa, Iwao; Seto, Yoshihisa; Tsuboi, Akio

    2013-06-01

    Sudden death in a hot bathtub occurs frequently in Japan, particularly among elderly people. This retrospective report describes the epidemiologic circumstances and physical findings at autopsy. In total, 268 victims were found unconscious or dead during tub bathing. After postmortem examination, the manner of death was judged as natural cause in 191 (71.2%) and accidental drowning in 63 (23.5%) cases. Mean age (SD) was 72.1 (15.2) years with no significant difference between males and females. A seasonal difference was evident: the winter displayed the highest frequency. Drowning water inhalation, which was confirmed in 72% of victims, was absent in the others. The most common observations on postmortem examination were cardiac ischemic changes and cardiomegaly. Water inhalation signs were evident in a significantly fewer victims exhibiting these factors. In contrast, inhalational findings were observed more frequently in victims with other backgrounds such as alcohol intake, mobility disturbance, and history of epilepsy. Annual mortality in Japan from accidental drowning in persons aged older than 75 years is 33 deaths per 100,000 population. However, this number may be considerably underestimated as pathologists tend to regard lack of water inhalation as indicating a natural cause of death. Confusion in diagnosis remains consequent to the accidental and natural aspects of "dead in hot bathtub" phenomenon.

  12. Accidental falls involving medical implant re-operation.

    Science.gov (United States)

    Ong, Kevin L; Lau, Edmund; Moore, Tara; Heller, Michelle F

    2009-10-01

    Implantation of medical devices is becoming more prevalent, and as a result, a greater number of patients who fall accidentally are expected to have a medical implant. The Nationwide Inpatient Sample (NIS) was used to evaluate hospital admissions following accidental falls involving re-operation of existing medical implants (hip, knee, spine, and fracture fixation) from 1990 to 2005. From 1990 to 2005, hospitalisations due to accidental falls on level surfaces increased by 306%, and hospitalisations due to falls from stairs increased by 310%. Falls involving orthopaedic revision surgery (re-operation) are relatively rare, but the incidence has increased by approximately 35%. Hospital stays after falls on level surfaces involving re-operation were 1.0 day (median) longer and cost 50% (median) more than those that did not involve re-operation in 2005. After staircase falls, hospital stays for patients undergoing re-operations were 2.0 days (median) longer and cost 108% (median) more. The greater hospital costs and hospital stay for patients needing re-operations indicate that additional medical treatment was required.

  13. Colonoscopy and computerised tomography scan are not sufficient to localise right sided colonic lesions accurately.

    LENUS (Irish Health Repository)

    Solon, Jacqueline Gemma

    2009-11-23

    : Aim: accurate pre-operative localisation of colonic lesions is critical especially in laparoscopic colectomy where tactile localisation is absent particularly in screen-detected tumours. The study aimed to evaluate the accuracy of colonoscopy and double-contrast computerised tomography (CT) to localise lesions treated by right hemicolectomy. Method: a retrospective chart review was performed of patients treated by right hemicolectomy under the colorectal service between July 2003 and October 2006. Pre-operative tumour location determined by CT scan and colonoscopy were compared with the intra-operative and histopathologic findings. Results: of 101 patients, 73 (73%) were for adenoma or cancer, with a final diagnosis of adenocarcinoma in 59 (59%). Pre-operative localisation was inaccurate in 29% of lesions using both CT and colonoscopy. In the transverse colon colonoscopy alone was only 37.5% accurate, increasing to 62.5% when information from the CT scan was added. Conclusion: pre-operative localisation of right-sided colon cancers using colonoscopy and CT scanning is unreliable in at least 29% of cases. Inaccurate localisation of transverse colon tumours risks inadequate lymphadenectomy with an adverse cancer outcome. Pre-operative abdominal CT scan improves accuracy but endoscopic tattoo localisation should be employed routinely especially in patients undergoing laparoscopic resection.

  14. Optimal localisation of next generation Biofuel production in Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Wetterlund, Elisabeth [Linkoeping Univ., Linkoeping (Sweden); Pettersson, Karin [Chalmers Univ. of Technology, Goeteborg (Sweden); Mossberg, Johanna [SP Technical Research Inst. of Sweden, Boraas (Sweden)] [and others

    2013-09-01

    With a high availability of lignocellulosic biomass and various types of cellulosic by-products, as well as a large number of industries, Sweden is a country of great interest for future large scale production of sustainable, next generation biofuels. This is most likely also a necessity as Sweden has the ambition to be independent of fossil fuels in the transport sector by the year 2030 and completely fossil free by 2050. In order to reach competitive biofuel production costs, plants with large production capacities are likely to be required. Feedstock intake capacities in the range of about 1-2 million tonnes per year, corresponding to a biomass feed of 300-600 MW, can be expected, which may lead to major logistical challenges. To enable expansion of biofuel production in such large plants, as well as provide for associated distribution requirements, it is clear that substantial infrastructure planning will be needed. The geographical location of the production plant facilities is therefore of crucial importance and must be strategic to minimise the transports of raw material as well as of final product. Competition for the available feedstock, from for example forest industries and CHP plants (combined heat and power) further complicates the localisation problem. Since the potential for an increased biomass utilisation is limited, high overall resource efficiency is of great importance. Integration of biofuel production processes in existing industries or in district heating systems may be beneficial from several aspects, such as opportunities for efficient heat integration, feedstock and equipment integration, as well as access to existing experience and know-how. This report describes the development of Be Where Sweden, a geographically explicit optimisation model for localisation of next generation biofuel production plants in Sweden. The main objective of developing such a model is to be able to assess production plant locations that are robust to varying

  15. Radioguided localisation of impalpable breast lesions using 99m-Technetium macroaggregated albumin: Lessons learnt during introduction of a new technique to guide preoperative localisation

    Energy Technology Data Exchange (ETDEWEB)

    Landman, Joanne [Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia); Kulawansa, Sagarika [Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia (Australia); McCarthy, Michael; Troedson, Russell [Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia); Phillips, Michael [Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia (Australia); Tinning, Jill [The Multidisciplinary Breast Service, Royal Perth Hospital, Perth, Western Australia (Australia); Taylor, Donna, E-mail: Donna.Taylor@health.wa.gov.au [Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia (Australia); School of Surgery, University of Western Australia, Perth, Western Australia (Australia); Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia)

    2015-03-15

    Preoperative wire-guided localisation (WGL) of impalpable breast lesions is widely used but can be technically difficult. Risks include wire migration, inaccurate placement, and inadequate surgical margins. Research shows that radioguided occult lesion localisation (ROLL) is quicker, easier, and can improve surgical and cosmetic outcomes. An audited introduction of ROLL was conducted to validate the technique as a feasible alternative to WGL. Fifty patients with single impalpable lesions and biopsy proven malignancy or indeterminate histology underwent WGL followed by intralesional radiopharmaceutical injection of 99m-Technetium macroaggregated albumin. Postprocedural mammography was performed to demonstrate wire position, and scintigraphy to evaluate radiopharmaceutical migration. Lymphoscintigraphy and intraoperative sentinel node biopsy were performed if indicated, followed by lesion localisation and excision using a gamma probe. Specimen imaging was performed, with immediate reexcision for visibly inadequate margins. Accurate localisation was achieved in 86% of patients with ROLL compared to 72% with WGL. All lesions were successfully removed, with clear margins in 71.8% of malignant lesions. Reexcision and intraoperative sentinel node localisation rates were equivalent to preaudit figures for WGL. ROLL was easy to perform and problems were infrequent. Inaccurate radiopharmaceutical placement necessitating WGL occurred in four patients. Minor radiopharmaceutical migration was common, but precluded using ROLL in only two cases. ROLL is effective, simple, inexpensive, and easily learnt; however, preoperative confirmation of correct radiopharmaceutical placement using mammography and the gamma probe is important to help ensure successful lesion removal. Insertion of a backup hookwire is recommended during the initial introduction of ROLL.

  16. Anderson localisation and optical-event horizons in rogue-soliton generation

    CERN Document Server

    Saleh, Mohammed F; Biancalana, Fabio

    2016-01-01

    We show that the true origin of rogue solitons in optical fibres is due to the combined action of linear Anderson localisation and the formation of optical-event horizons. Anderson localised modes are formed in certain temporal locations due to the random background noise. Such localised modes seed the formation of solitary waves at those preferred locations, while the strongest Anderson mode generates the rogue soliton. The event horizon effect between dispersive waves and solitons produces an artificial collective acceleration that favours the collision of solitons during the rogue wave formation.

  17. Deconfinement, chiral transition and localisation in a QCD-like model

    Science.gov (United States)

    Giordano, Matteo; Katz, Sándor D.; Kovács, Tamás G.; Pittler, Ferenc

    2017-02-01

    We study the problems of deconfinement, chiral symmetry restoration and localisation of the low Dirac eigenmodes in a toy model of QCD, namely unimproved staggered fermions on lattices of temporal extension N T = 4. This model displays a genuine deconfining and chirally-restoring first-order phase transition at some critical value of the gauge coupling. Our results indicate that the onset of localisation of the lowest Dirac eigenmodes takes place at the same critical coupling where the system undergoes the first-order phase transition. This provides further evidence of the close relation between deconfinement, chiral symmetry restoration and localisation of the low modes of the Dirac operator on the lattice.

  18. Antenna array geometry optimization for a passive coherent localisation system

    Science.gov (United States)

    Knott, Peter; Kuschel, Heiner; O'Hagan, Daniel

    2012-11-01

    Passive Coherent Localisation (PCL), also known as Passive Radar, making use of RF sources of opportunity such as Radio or TV Broadcasting Stations, Cellular Phone Network Base Stations, etc. is an advancing technology for covert operation because no active radar transmitter is required. It is also an attractive addition to existing active radar stations because it has the potential to discover low-flying and low-observable targets. The CORA (Covert Radar) experimental passive radar system currently developed at Fraunhofer-FHR features a multi-channel digital radar receiver and a circular antenna array with separate elements for the VHF- and the UHF-range and is used to exploit alternatively Digital Audio (DAB) or Video Broadcasting (DVB-T) signals. For an extension of the system, a wideband antenna array is being designed for which a new discone antenna element has been developed covering the full DVB-T frequency range. The present paper describes the outline of the system and the numerical modelling and optimisation methods applied to solve the complex task of antenna array design: Electromagnetic full wave analysis is required for the parametric design of the antenna elements while combinatorial optimization methods are applied to find the best array positions and excitation coefficients for a regular omni-directional antenna performance. The different steps are combined in an iterative loop until the optimum array layout is found. Simulation and experimental results for the current system will be shown.

  19. Testate amoeba transfer function performance along localised hydrological gradients.

    Science.gov (United States)

    Tsyganov, Andrey N; Mityaeva, Olga A; Mazei, Yuri A; Payne, Richard J

    2016-09-01

    Testate amoeba transfer functions are widely used for reconstruction of palaeo-hydrological regime in peatlands. However, the limitations of this approach have become apparent with increasing attention to validation and assessing sources of uncertainty. This paper investigates effects of peatland type and sampling depth on the performance of a transfer function using an independent test-set from four Sphagnum-dominated sites in European Russia (Penza Region). We focus on transfer function performance along localised hydrological gradients, which is a useful analogue for predictive ability through time. The performance of the transfer function with the independent test-set was generally weaker than for the leave-one-out or bootstrap cross-validations. However, the transfer function was robust for the reconstruction of relative changes in water-table depth, provided the presence of good modern analogues and overlap in water-table depth ranges. When applied to subsurface samples, the performance of the transfer function was reduced due to selective decomposition, the presence of deep-dwelling taxa or vertical transfer of shells. Our results stress the importance of thorough testing of transfer functions, and highlight the role of taphonomic processes in determining results. Further studies of stratification, taxonomy and taphonomy of testate amoebae will be needed to improve the robustness of transfer function output.

  20. Polarity of localised conversion in Streptococcus pneumoniae transformation.

    Science.gov (United States)

    Mostachfi, P; Sicard, A M

    1987-06-01

    Localised conversion in pneumococcal transformation is a process that spans a few nucleotides when the 5'-ATTAAT/3'-TAAGTA configuration occurs at the pairing step. It was first observed in two-point crosses between an amiA mutation (amiA36) carrying this sequence and other closely linked mutants of the locus. The yield of the amiA resistance allele conversion to wild type is 20%. In order to characterize this process, which differs from long-patch conversion by the length of DNA repair, gene requirements and sequence specificity, we devised experiments to detect the reciprocal conversion, AmiA+ to AmiAr. For this purpose we examined the suppressibility by a pneumococcal informational suppressor of several nonsense mutations at the locus. Amber (UAG) and ochre (UAA) mutations are suppressed whereas UGA is not suppressed. In this genetic background, where amiA36 is partly suppressed, it was possible to select for double mutants in a cross between amiA36 and a closely linked non-suppressible marker. Direct isolation of such double mutants was also performed without any screening in crosses between amiA36 and the same linked marker in cloned DNA. The frequency of double mutants was very low (1/175) suggesting that there is no conversion of wild-type to mutant alleles. Thus conversion is a polarized process changing specifically A to C.

  1. Localised measurements of turbulence in the Tore Supra tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Devynck, P.; Garbet, X.; Laviron, C.; Payan, J.; Saha, S.K. [Association Euratom-CEA, Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Gervais, F.; Hennequin, P.; Quemeneur, A.; Truc, A. [Ecole Polytechnique, 91 - Palaiseau (France). Lab. de Physique des Milieux Ionises

    1992-04-01

    A collective infra-red laser scattering diagnostic has been installed on the TORE SUPRA tokamak for the measurement of plasma density fluctuations. For the range of wave numbers explored (3-15 cm{sup -1}), the scattering angles are very weak (about 1 mrad). Consequently, the scattering signals are averaged along the whole observation chord, resulting in poor longitudinal spatial localisation. However, by virtue of the pitch angle variation of the magnetic field lines in the tokamak, and of the perpendicularity of the turbulence wave vector to these field lines, it has been possible to obtain partial spatial resolution along the direction of the beam. Good agreement between the experimental and theoretical angular resolution of the diagnostic as well as the results of cross-correlation performed on the signals obtained by two simultaneous probing beams also justify this novel concept. From the variation of the fluctuation power with the orientation angle of the observed wave sector, it has been possible to deduce the radial fluctuation profile by a deconvolution procedure, showing that the fluctuations increase sharply near the edge. The k-spectrum was also measured and shows a k{sup -3} dependence for k>6 cm{sup -1}. Experimental evidences are put forward to show that the k-spectrum is neither purely poloidal nor purely radial in the (k{sub r}-k{sub {theta}}) plane.

  2. Le kyste hydatique du cordon spermatique: une localisation exceptionnelle

    Science.gov (United States)

    Hamdane, Mohamed Moncef; Bougrine, Fethi; Msakni, Issam; Dhaoui-Ghozzi, Amen; Bouziani, Ammar

    2011-01-01

    L’ hydatidose est une anthropo-zoonose due au développement chez l'homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extrêmement rare avec seulement 4 cas rapportés dans la littérature. Les auteurs rapportent dans cet article un nouveau cas d'hydatidose du cordon spermatique. Il s'agissait d'un homme de 40 ans qui consultait pour des douleurs scrotales évoluant depuis huit mois. L'examen clinique a mis en évidence une tuméfaction mobile, inguino-scrotale, droite. L’échographie testiculaire a objectivé une hernie inguinale droite associée à deux kystes épididymaires bilatéraux. Le patient a été opéré pour cure de son hernie avec découverte en per-opératoire d'un kyste du cordon spermatique qui a été réséqué. L'examen anatomopathologique a conclu à une hydatidose du cordon spermatique. PMID:22384304

  3. Globally reasoning about localised security policies in distributed systems

    CERN Document Server

    Hernandez, Alejandro Mario

    2012-01-01

    In this report, we aim at establishing proper ways for model checking the global security of distributed systems, which are designed consisting of set of localised security policies that enforce specific issues about the security expected. The systems are formally specified following a syntax, defined in detail in this report, and their behaviour is clearly established by the Semantics, also defined in detail in this report. The systems include the formal attachment of security policies into their locations, whose intended interactions are trapped by the policies, aiming at taking access control decisions of the system, and the Semantics also takes care of this. Using the Semantics, a Labelled Transition System (LTS) can be induced for every particular system, and over this LTS some model checking tasks could be done. We identify how this LTS is indeed obtained, and propose an alternative way of model checking the not-yet-induced LTS, by using the system design directly. This may lead to over-approximation th...

  4. Automated quantum conductance calculations using maximally-localised Wannier functions

    CERN Document Server

    Shelley, Matthew; Mostofi, Arash A; Marzari, Nicola

    2011-01-01

    A robust, user-friendly, and automated method to determine quantum conductance in disordered quasi-one-dimensional systems is presented. The scheme relies upon an initial density- functional theory calculation in a specific geometry after which the ground-state eigenfunctions are transformed to a maximally-localised Wannier function (MLWF) basis. In this basis, our novel algorithms manipulate and partition the Hamiltonian for the calculation of coherent electronic transport properties within the Landauer-Buttiker formalism. Furthermore, we describe how short- ranged Hamiltonians in the MLWF basis can be combined to build model Hamiltonians of large (>10,000 atom) disordered systems without loss of accuracy. These automated algorithms have been implemented in the Wannier90 code[Mostofi et al, Comput. Phys. Commun. 178, 685 (2008)], which is interfaced to a number of electronic structure codes such as Quantum-ESPRESSO, AbInit, Wien2k, SIESTA and FLEUR. We apply our methods to an Al atomic chain with a Na defect...

  5. Accidental introductions are an important source of invasive plants in the continental United States.

    Science.gov (United States)

    Lehan, Nora E; Murphy, Julia R; Thorburn, Lukas P; Bradley, Bethany A

    2013-07-01

    Preventing new plant invasions is critical for reducing large-scale ecological change. Most studies have focused on the deliberate introduction of nonnatives via the ornamental plant trade. However, accidental introduction may be an important source of nonnative, invasive plants. Using Web and literature searches, we compiled pathways of introduction to the United States for 1112 nonnative plants identified as invasive in the continental United States. We assessed how the proportion of accidentally and deliberately introduced invasive plants varies over time and space and by growth habit across the lower 48 states. Deliberate introductions of ornamentals are the primary source of invasive plants in the United States, but accidental introductions through seed contaminants are an important secondary source. Invasive forbs and grasses are the most likely to have arrived accidentally through seed contaminants, while almost all nonnative, invasive trees were introduced deliberately. Nonnative plants invading eastern states primarily arrived deliberately as ornamentals, while a high proportion of invasive plants in western states arrived accidentally as seed contaminants. Accidental introductions may be increasing in importance through time. Before 1850, 10 of 89 (11%) of invasive plants arrived accidentally. After 1900, 20 of 65 (31%) arrived accidentally. Recently enacted screening protocols and weed risk assessments aim to reduce the number of potentially invasive species arriving to the United States via deliberate introduction pathways. Increasing proportions of accidentally introduced invasive plants, particularly associated with contaminated seed imports across the western states, suggest that accidental introduction pathways also need to be considered in future regulatory decisions.

  6. Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2

    Science.gov (United States)

    Ruane, Peter T.; Gumy, Laura F.; Bola, Becky; Anderson, Beverley; Wozniak, Marcin J.; Hoogenraad, Casper C.; Allan, Victoria J.

    2016-01-01

    Microtubules and their associated proteins (MAPs) underpin the polarity of specialised cells. Adenomatous polyposis coli (APC) is one such MAP with a multifunctional agenda that requires precise intracellular localisations. Although APC has been found to associate with kinesin-2 subfamily members, the exact mechanism for the peripheral localization of APC remains unclear. Here we show that the heavy chain of kinesin-1 directly interacts with the APC C-terminus, contributing to the peripheral localisation of APC in fibroblasts. In rat hippocampal neurons the kinesin-1 binding domain of APC is required for its axon tip enrichment. Moreover, we demonstrate that APC requires interactions with both kinesin-2 and kinesin-1 for this localisation. Underlining the importance of the kinesin-1 association, neurons expressing APC lacking kinesin-1-binding domain have shorter axons. The identification of this novel kinesin-1-APC interaction highlights the complexity and significance of APC localisation in neurons. PMID:27272132

  7. An efficient approach to node localisation and tracking in wireless sensor networks

    CSIR Research Space (South Africa)

    Mwila, MK

    2014-12-01

    Full Text Available function, that can be used in a distributed localisation algorithm, are developed. This study also introduces a sensor data fusion approach, combining accelerometer data, RSSI, antenna radiation pattern and node orientation to reduce the computation...

  8. An Ising-Anderson model of localisation in high-temperature QCD

    CERN Document Server

    Giordano, Matteo; Pittler, Ferenc

    2015-01-01

    We discuss a possible mechanism leading to localisation of the low-lying Dirac eigenmodes in high-temperature lattice QCD, based on the spatial fluctuations of the local Polyakov lines in the partially ordered configurations above $T_c$. This mechanism provides a qualitative explanation of the dependence of localisation on the temperature and on the lattice spacing, and also of the phase diagram of QCD with an imaginary chemical potential. To test the viability of this mechanism we propose a three-dimensional effective, Anderson-like model, mimicking the effect of the Polyakov lines on the quarks. The diagonal, on-site disorder is governed by a three-dimensional Ising-like spin model with continuous spins. Our numerical results show that localised modes are indeed present in the ordered phase of the Ising model, thus supporting the proposed mechanism for localisation in QCD.

  9. A Novel Application of Non-Destructive Readout Technology to Localisation Microscopy

    Science.gov (United States)

    Barnett, Samuel F. H.; Snape, Mary; Hunter, C. Neil; Juárez, Miguel A.; Cadby, Ashley J.

    2017-02-01

    The fitting precision in localisation microscopy is highly dependent on the signal to noise ratio. To increase the quality of the image it is therefore important to increase the signal to noise ratio of the measurements. We present an imaging system for localisation microscopy based on non-destructive readout camera technology that can increase the signal to noise ratio of localisation based microscopy. This approach allows for much higher frame rates through subsampling a traditional camera frame. By matching the effective exposure to both the start time and duration of a single molecule we diminish the effects of read noise and temporal noise. We demonstrate the application of this novel method to localisation microscopy and show both an increase in the attainable signal to noise ratio of data collection and an increase in the number of detected events.

  10. Approach to sensor node calibration for efficient localisation in wireless sensor networks in realistic scenarios

    CSIR Research Space (South Africa)

    Mwila, MK

    2014-06-01

    Full Text Available Conference on Ambient Systems, Networks and Technologies (ANT-2014) Approach to Sensor Node Calibration for Efficient Localisation in Wireless Sensor Networks in Realistic Scenarios Martin K. Mwilaa, Karim Djouanib, Anish Kurienc,∗ a...

  11. Planar localisation analyses: a novel application of a centre of mass approach.

    Science.gov (United States)

    Edmondson-Jones, A Mark; Irving, Samuel; Moore, David R; Hall, Deborah A

    2010-08-01

    Sound localisation is one of the key roles for listening, and measuring localisation performance is a mainstay of the hearing research laboratory. Such measurements may consider both accuracy and, for incorrect trials, the size of the error. In terms of error analysis, localisation studies have frequently used general purpose univariate techniques in conjunction with either mean signed or unsigned error measurements. This approach can make inappropriate distributional assumptions and so more suitable alternatives based on directional statistics have also been used. Here we investigate the use of a variety of methods, assess their performance, and comment on their use and availability. We also describe a novel use of a 'centre of mass' approach for describing localisation data jointly in terms of accuracy and size of error. This spatial method offers powerful, yet flexible, statistical analysis using standard multivariate analysis of variance (MANOVA).

  12. An efficient distributed localisation algorithm for wireless sensor networks: based on smart reference-selection method

    CSIR Research Space (South Africa)

    Abu-Mahfouz, Adnan M

    2013-05-01

    Full Text Available Determining the location of nodes is a key part of wireless sensor networks (WSNs). Many WSN applications require knowledge of nodes’ locations to perform their functions successfully. Several localisation algorithms rely on using all or most...

  13. A robust co-localisation measurement utilising z-stack image intensity similarities for biological studies.

    Directory of Open Access Journals (Sweden)

    Yinhai Wang

    Full Text Available BACKGROUND: Co-localisation is a widely used measurement in immunohistochemical analysis to determine if fluorescently labelled biological entities, such as cells, proteins or molecules share a same location. However the measurement of co-localisation is challenging due to the complex nature of such fluorescent images, especially when multiple focal planes are captured. The current state-of-art co-localisation measurements of 3-dimensional (3D image stacks are biased by noise and cross-overs from non-consecutive planes. METHOD: In this study, we have developed Co-localisation Intensity Coefficients (CICs and Co-localisation Binary Coefficients (CBCs, which uses rich z-stack data from neighbouring focal planes to identify similarities between image intensities of two and potentially more fluorescently-labelled biological entities. This was developed using z-stack images from murine organotypic slice cultures from central nervous system tissue, and two sets of pseudo-data. A large amount of non-specific cross-over situations are excluded using this method. This proposed method is also proven to be robust in recognising co-localisations even when images are polluted with a range of noises. RESULTS: The proposed CBCs and CICs produce robust co-localisation measurements which are easy to interpret, resilient to noise and capable of removing a large amount of false positivity, such as non-specific cross-overs. Performance of this method of measurement is significantly more accurate than existing measurements, as determined statistically using pseudo datasets of known values. This method provides an important and reliable tool for fluorescent 3D neurobiological studies, and will benefit other biological studies which measure fluorescence co-localisation in 3D.

  14. Photon counting imaging and centroiding with an electron-bombarded CCD using single molecule localisation software

    OpenAIRE

    Hirvonen, Liisa Maija; Barber, Matthew; Suhling, Klaus

    2016-01-01

    Photon event centroiding in photon counting imaging and single-molecule localisation in super-resolution fluorescence microscopy share many traits. Although photon event centroiding has traditionally been performed with simple single-iteration algorithms, we recently reported that iterative fitting algorithms originally developed for single-molecule localisation fluorescence microscopy work very well when applied to centroiding photon events imaged with an MCP-intensified CMOS camera. Here, w...

  15. How active ingredient localisation in plant tissues determines the targeted pest spectrum of different chemistries

    DEFF Research Database (Denmark)

    Buchholz, Anke; Trapp, Stefan

    2016-01-01

    adsorption into leaf cells and thus a favourable distribution into apoplast and xylem sap. Slightly lipophilic bases get trapped in vacuoles, which is a less suited place to control hemipteran pests but appropriate to control mites. Non-favourable cellular localisation led to a strong reduction...... in translaminar efficacy against phloem feeders. CONCLUSION: Prediction and optimisation of intracellular localisation of pesticides add valuable new information for targeted bioavailability and can indicate directions for improved pesticide design. © 2015 Society of Chemical Industry....

  16. Evaluation and treatment of accidental autoinjection of epinephrine.

    Science.gov (United States)

    Peyko, Vincent; Cohen, Victor; Jellinek-Cohen, Samantha P; Pearl-Davis, Michelle

    2013-05-01

    A case of accidental autoinjection of epinephrine is described. A 47-year-old man arrived at the emergency department after accidental injection of epinephrine with an autoinjector into his left thumb. His vital signs were stable at admission. The patient was allergic to nuts and thought he may have eaten something containing a pine nut. The patient reported feeling itching in his throat but had no shortness of breath or swollen tongue. He tried to self-administer an epinephrine injection, but it did not inject. While he was checking the device, it accidently injected into his left thumb pad. A review of systems revealed throat discomfort, a tingling sensation of the tongue, and a left-thumb puncture with pain. Physical examination of the left thumb pad revealed a pale, cool thumb with diminished capillary refill and punctuate black discoloration at the site of injection. Topical nitroglycerin paste was applied but had no effect, so terbutaline was ordered. The terbutaline injection was prepared as a 1:1 preparation of terbutaline sulfate 1 mg/mL and 0.9% sodium chloride injection. The immediate effects were the return of color from pale white to red and observable perfusion to the area within seconds. After 20 minutes, the red color remained, with observable perfusion and warmth, in addition to complete neurosensory function. Sixty minutes after terbutaline administration, the patient was discharged home. A 47-year-old man who accidentally injected himself in the thumb with an epinephrine autoinjector was successfully treated with subcutaneous terbutaline. The treatment had an immediate effect, including revascularization and resolution of pain.

  17. Numerical simulation of industrial and accidental release formation and transport

    Energy Technology Data Exchange (ETDEWEB)

    Piskunov, V.N.; Aloyan, A.A.; Gerasimov, V.M.; Pinaev, V.S.; Golubev, A.I.; Yanilkin, Yu.V.; Ivanov, N.V.; Nikonov, S.N.; Kharchenko, A.I. [and others

    1995-05-01

    Statement of work for contract 006 {open_quotes}Mathematical simulation of industrial and accidental release formation and transport{close_quotes} implies that the final result of the activity within this task will be VNIIEF developed techniques which will provide for the prediction of the post-accidental environment. Report [1] presents the description of physical models and calculation techniques which were chosen by VNIIEF to accomplish this task. These techniques were analysed for their capabilities, the areas of their application were defined, modifications within contract 006 were described, the results of test and methodical calculations were presented. Moreover, the experimental data were analysed over the source parameters and contamination measurements which can be used in the comparison with the calculation results. Based an these data this report compares the calculation results obtained with VNIIEF calculation techniques with the LANL-presented experimental results. The calculations which statements and results are given in section 1, included the following processes: explosion cloud ascent dynamics and jet release origin; aerosols kinetics in the release source including composite particle origin in the explosion cloud caused by radioactive substance sorption an the soil particles; contaminant transport in atmosphere and their in-site fallout due to the accidental explosions and fires; atmospheric flow dynamics and industrial contamination transfer over the complicated terrain. The calculated results were compared with the experimental data. Section 2 presents the parameters for a typical source in the explosion accidents based an the experimental results and calculated data from Section 1, as well as contamination patterns were calculated with basic technique {open_quotes}Prognosis{close_quotes}.

  18. Biological dose estimation for accidental supra-high dose gamma-ray exposure

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y., E-mail: yingchen29@yahoo.com.cn [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China); Yan, X.K. [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China); Department of Radiation Safety, Beijing Institute of Nuclear and Chemical Safety, 14 Guan-cun, Dongcheng District, Beijing 100077 (China); Du, J.; Wang, Z.D.; Zhang, X.Q.; Zeng, F.G.; Zhou, P.K. [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China)

    2011-09-15

    To correctly estimate the biological dose of victims accidentally exposed to a very high dose of {sup 60}Co gamma-ray, a new dose-effect curve of chromosomal dicentrics/multicentrics and rings in the supra-high dose range was established. Peripheral blood from two healthy men was irradiated in vitro with doses of {sup 60}Co gamma-rays ranging from 6 to 22 Gy at a dose rate of 2.0 Gy/min. Lymphocytes were concentrated, cultured and harvested at 52 h, 68 h and 72 h. The numbers of dic + r were counted. The dose-effect curves were established and validated using comparisons with doses from the Tokai-mura accident and were then applied to two victims of supra-high dose exposure accident. The results indicated that there were no significant differences in chromosome aberration frequency among the different culture times from 52 h to 72 h. The 6-22 Gy dose-effect curve was fitted to a linear quadratic model Y = -2.269 + 0.776D - 7.868 x l0{sup -3}D{sup 2}. Using this mathematic model, the dose estimates were similar to data from Tokai-mura which were estimated by PCC ring. Whole body average doses of 9.7 Gy and 18.1 Gy for two victims in the Jining accident were satisfactorily given. We established and successfully applied a new dose-effect curve of chromosomal dicentrics plus ring (dic + r) after 6-22 Gy {gamma}-irradiation from a supra-high dose {sup 60}Co gamma-ray accident.

  19. Lack of rise in serum prolactin following yttrium-90 interstitial irradiation for acromegaly

    Energy Technology Data Exchange (ETDEWEB)

    Clark, A.J.L.; Chahal, P.; Mashiter, K.; Joplin, G.F. (Royal Postgraduate Medical School, London (UK))

    1983-11-01

    The authors have investigated the possibility that the increase in serum PRL levels observed in patients with acromegaly treated with external irradiation could be due to damage to the hypothalamus or portal vessels, by comparing the effects of yttrium-90 interstitial irradiation, which is highly localised and does not normally extend to the hypothalamus, in a similar series of patients. These results are consistent with the hypothesis; a less likely explanation is that an overgrowth of radio-resistant PRL-secreting tumour cells is occurring after external irradiation, but not after yttrium-90 implantation.

  20. Accidental Degeneracy and Berry Phase of Resonant States

    CERN Document Server

    Mondragón, A

    1997-01-01

    We study the complex geometric phase acquired by the resonant states of an open quantum system which evolves irreversibly in a slowly time dependent environment. In analogy with the case of bound states, the Berry phase factors of resonant states are holonomy group elements of a complex line bundle with structure group C*. In sharp contrast with bound states, accidental degeneracies of resonances produce a continuous closed line of singularities formally equivalent to a continuous distribution of "magnetic" charge on a "diabolical" circle, in consequence, we find different classes of topologically inequivalent non-trivial closed paths in parameter space.

  1. Accidente Isquémico Transitorio: la gran oportunidad

    Directory of Open Access Journals (Sweden)

    Mª Dolores Fernández Couto

    2013-09-01

    Full Text Available El ictus constituye la primera causa de muerte en mujeres y la segunda causa de muerte global en España1, así como la primera causa de discapacidad adquirida en la edad adulta y la segunda causa de demencia por detrás de la enfermedad de Alzheimer. El accidente isquémico transitorio (AIT precede al ictus isquémico en un 23% de los casos2. Esta señal de alarma, lejos de poder considerarse banal, constituye una gran oportunidad para la prevención.

  2. Accidental Chemical Burns of Oral Mucosa by Herbicide

    Directory of Open Access Journals (Sweden)

    S P Deo

    2012-03-01

    Full Text Available Glyphosate (GlySH is a broad spectrum, nonselective herbicide, widely used in agriculture. This case report describes a 25-year-old man presenting with extensive chemical burns and ulceration of the oral cavity as a result of accidental exposure to GlySH. This paper aims to illustrate the typical appearance of GlySH related chemical mucosal burn and to demonstrate the severity of the corrosive effect of GlySH which need team approach to prevent unfavorable sequelae such as microstomia. Keywords: Chemical burns, corrosive injury, glyphosate poisoning, herbicide, microstomia, oral mucosal burn.

  3. Clinical perspectives on osteogenesis imperfecta versus non-accidental injury.

    Science.gov (United States)

    Pereira, Elaine Maria

    2015-12-01

    Although non-accidental injuries (NAI) are more common in cases of unexplained fractures than rare disorders such as osteogenesis imperfecta (OI), ruling out OI and other medical causes of fracture is always indicated. The majority of OI patients can be diagnosed with the help of family history, physical examination, and radiographic findings. In particular, there are a few radiological findings which are seen more commonly in NAI than in OI which may help guide clinician considerations regarding the probability of either of these diagnoses. At the same time, molecular testing still merits careful consideration in cases with unexplained fractures without obvious additional signs of abuse.

  4. Costes e Investigación de Accidentes Laborales

    OpenAIRE

    Gonzalez Quintana, Jon Ander

    2013-01-01

    En España en el año 2011, según datos del Instituto Nacional de Estadística (INE), se registraron 581.150 accidentes con baja laboral de los cuales el 88% sucedieron dentro de jornada laboral. Observando estas cifras, es obvio que hay una carencia en el sistema preventivo y, por los tanto, es necesario buscar una solución. Son tres los factores de la baja inversión en prevención: la falta de concienciación de las empresas, la falta del conocimiento de las consecuencias de un...

  5. D-transallethrin: An unusual agent for accidental poisoning

    Directory of Open Access Journals (Sweden)

    Vinod Kedari

    2016-01-01

    Full Text Available D-trans allethrin, a pyrethroid, is commonly used as a coil mosquito repellant. There are very few reports of human toxicity due to D-trans allethrin. We present the case of an 11-month-old boy who presented to us with excessive salivation, altered sensorium and convulsions following alleged accidental ingestion of a coil containing D-transallethrin. He required mechanical ventilation for a brief period and made a full recovery. Although rare, the possibility of pyrethroid poisoning should be kept in mind in children who present with sudden onset unconsciousness or convulsions.

  6. Measurement of accidental coincidences for higher activity sources

    CERN Document Server

    Yull Hwang, H; Jae-Oh, P; Man-Lee, J; Kie-Lee, M

    1999-01-01

    The multi-channel time-scaling (MCTS) technique has been applied for the measurement of accidental coincidences for the cases of higher activity samples in beta-gamma coincidence counting. Two beta samples of sup 1 sup 3 sup 4 Cs were prepared and the nominal activities observed in the beta counter were about 7000 and 11000 s sup - sup 1 , respectively. The obtained true coincidence rates are independent of resolving times and dead times. They are compared with those calculated from the mathematical model derived by Cox and Isham.

  7. Tratamiento de Terapia Ocupacional en el accidente cerebrovascular

    OpenAIRE

    Domingo García, AM

    2006-01-01

    RESUMENEntre los muchos pacientes que necesitan tratamiento rehabilitador en Terapia Ocupacional están los que en la edad adulta han sufrido un accidente cerebrovascular.Uno de los factores de riesgo asociados con más frecuencia a las alteraciones del sistema nervioso central es el progresivo envejecimiento de la población, debido a esto orientaré el siguiente artículo hacia la intervención sobre la población geriátrica.La Terapia Ocupacional ofrece un tratamiento global que abarca las áreas ...

  8. Accidentes de trabajo en un hospital de agudos

    Directory of Open Access Journals (Sweden)

    Pérez Bermúdez B.

    1998-01-01

    Full Text Available FUNDAMENTO: El mejor conocimiento de los determinantes y circunstancias de producción de los accidentes laborales, favorecerá la implantación de medidas correctoras. El objetivo de este trabajo es describir la evolución temporal de los accidentes de trabajo (AT y determinar los factores de riesgo de baja médica en el Hospital Dr. Peset de Valencia. MÉTODOS: Descripción y análisis retrospectivo de los accidentes de trabajo producidos en el Hospital Dr. Peset de Valencia durante los años 1992 a 1995. Se estimó por métodos deterministas la tendencia y estacionalidad de las series (índices estacionales, IE. Se aplicó un modelo de regresión logística para identificar los factores pronósticos de baja médica y determinar su probabilidad de ocurrencia . RESULTADOS: Las tasas más elevadas de AT se produjeron entre los trabajadores de cocina y lavandería (10,00 AT por 100 trabajadores-año. Los AT con baja médica mantienen una tendencia cercana a cero siendo febrero el mes con I.E más elevado (IE=139,8. Los que cursan sin baja médica tienen una tendencia positiva (r²=0,23, p<0,0001, siendo mayo el mes de mayor siniestralidad (IE=134,2. La probabilidad de que el accidente curse con baja médica aumenta significativamente con la edad, cuando se produce por la tarde, si ha tenido lugar en cocina/lavandería, y si se trata de un esguince o tendinitis. CONCLUSIONES: la actuación sobre la siniestralidad en los AT que cursen con IT, debería centrarse sobre los trabajos menos cualificados y en las áreas de cocina y lavandería.

  9. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application

    Directory of Open Access Journals (Sweden)

    Michael Froehle

    2012-01-01

    Full Text Available Mepivacaine is a potent local anaesthetic and used for infiltration and regional anaesthesia in adults and pediatric patients. Intoxications with mepivacaine affect mainly the CNS and the cardiovascular system. We present a case of accidental intravenous mepivacaine application and intoxication of an infant resulting in seizure, broad complex bradyarrhythmia, arterial hypotension and finally cardiac arrest. The patient could be rescued by prolonged resuscitations and a rapid initiation of ECMO and survived without neurological damage. The management strategies of this rare complication including promising other treatment options with lipid emulsions are discussed.

  10. Indoor Localisation Using a Context-Aware Dynamic Position Tracking Model

    Directory of Open Access Journals (Sweden)

    Montserrat Ros

    2012-01-01

    Full Text Available Indoor wireless localisation is a widely sought feature for use in logistics, health, and social networking applications. Low-powered localisation will become important for the next generation of pervasive media applications that operate on mobile platforms. We present an inexpensive and robust context-aware tracking system that can track the position of users in an indoor environment, using a wireless smart meter network. Our context-aware tracking system combines wireless trilateration with a dynamic position tracking model and a probability density map to estimate indoor positions. The localisation network consisted of power meter nodes placed at known positions in a building. The power meter nodes are tracked by mobile nodes which are carried by users to localise their position. We conducted an extensive trial of the context-aware tracking system and performed a comparison analysis with existing localisation techniques. The context-aware tracking system was able to localise a person's indoor position with an average error of 1.21 m.

  11. Intelligent UAV-Assisted Localisation to Conserve Battery Energy in Military Sensor Networks

    Directory of Open Access Journals (Sweden)

    P.Shunmuga Perumal

    2014-11-01

    Full Text Available Wireless sensor networks (WSNs are extensively used in military applications for border area monitoring, battle-field surveillance, tracking enemy troops, where the sensor nodes run on battery power. Localisation of sensor nodes is extremely important to identify the location of event in military applications for further actions. Existing localisation algorithms consume more energy by heavy computation and communication overheads. The objective of the proposed research is to increase the lifetime of the military sensor networks by reducing the power consumption in each sensor node during localisation. For the state-of-the-art, we propose a novel intelligent unmanned aerial vehicle anchor node (IUAN with an intelligent arc selection (IAS-based centralised localisation algorithm, which removes computation cost and reduces communication cost at every sensor node. The IUAN collects the signal strength, distance data from sensor nodes and the central control station (CCS computes the position of sensor nodes using IAS algorithm. Our approach significantly removes computation cost and reduces communication cost at each sensor node during localisation, thereby radically extends the lifetime and localisation coverage of the military sensor networks.Science Journal, Vol. 64, No. 6, November 2014, pp.557-563, DOI:http://dx.doi.org/10.14429/dsj.64.5295

  12. The Bulgarian Emergency Response System for dose assessment in the early stage of accidental releases to the atmosphere.

    Science.gov (United States)

    Syrakov, D; Veleva, B; Prodanova, M; Popova, T; Kolarova, M

    2009-02-01

    The Bulgarian Emergency Response System (BERS) is being developed in the Bulgarian National Institute of Meteorology and Hydrology since 1994. BERS is based on numerical weather forecast meteorological information and a numerical long-range dispersion model accounting for the transport, dispersion, chemical and radioactive transformations of pollutants. In the present paper, the further development of this system for a mixture of radioactive gaseous and aerosol pollutants is described. The basic module for the BERS, the numerical dispersion model EMAP, is upgraded with a "dose calculation block". Two scenarios for hypothetical accidental atmospheric releases from two NPPs, one in Western, and the other in Eastern Europe, are numerically simulated. The effective doses from external irradiation, from air submersion and ground shinning, effective dose from inhalation and absorbed dose by thyroid gland formed by 37 different radionuclides, significant for the early stage of a nuclear accident, are calculated as dose fields for both case studies and discussed.

  13. Multidisciplinary approach to "accidental" falls in the elderly: a case report.

    Science.gov (United States)

    Galizia, Gianluigi; Testa, Gianluca; Mazzella, Francesca; Cacciatore, Francesco; Ungar, Andrea; Masotti, Giulio; Rengo, Franco; Abete, Pasquale

    2008-06-01

    Falls in the elderly are commonly and often wrongly identified as "accidental". We report a case of an elderly woman admitted to first aid for a trauma due to an accidental fall. Geriatric multidisciplinary evaluation revealed mild cognitive impairment associated with depressive symptoms; both findings made the anamnesis uncertain. Syncope algorithm was applied and "tachy-brady form of sick sinus syndrome" was diagnosed. Differential diagnosis between "accidental" and "apparently accidental" falls in elderly patients is very difficult but a multidisciplinary geriatric evaluation can clarify the correct diagnosis.

  14. Accidental and experimental Closantel intoxication in Uruguayan sheep

    Directory of Open Access Journals (Sweden)

    Rodolfo Rivero

    2015-07-01

    Full Text Available Abstract An outbreak of Closantel intoxication in sheep in Uruguay is described. The outbreak occurred in a group of 1300 weaning lambs treated orally with a 10% solution of Closantel. One hundred forty eight lambs showed clinical signs of intoxication and 14 died. The clinical signs included mydriasis, nystagmus, and negative pupillary reflex, bilateral blindness, bump into objects, and lateral movement of the head. No macroscopic lesions were observed. The histological lesions of the retina were cytoplasmic vacuolization in ganglion cells and in cells of the inner and outer nuclear layers with different degrees of atrophy. Vacuolization and axonal degeneration were observed in the optic nerve, with multifocal areas of fibrosis and infiltration by lymphocytes and Gitter cells. To reproduce the intoxication, four sheep were given two, four and 10 times the therapeutic dose of Closantel (0.1g/kg of BW. Only the animals receiving 10 times the recommended dose showed clinical signs. The histological examination of the lesions in experimental sheep showed similar results to those described in the accidental outbreak, except for the absence of optic nerve fibrosis and inflammation, characterizing an acute phase. Axonal myelin sheaths loss, fibroblasts and collagen fibers were observed in the ultrastructural study of the optic nerve of accidental intoxicated animals. The optic nerve of experimentally intoxicated animals had vacuoles that separated the myelin sheaths of axons. To prevent outbreaks it is suggested to weigh the animals before Closantel administration to avoid errors in dose calculation.

  15. Accidental acute alcohol intoxication in infants: review and case report.

    Science.gov (United States)

    Minera, Gabriella; Robinson, Evan

    2014-11-01

    Acute alcohol intoxication in children younger than 18 months old is both rarely documented and rarely fatal. Previous case reports suggest hypoglycemia and faster than normal rates of alcohol elimination found in children with acute alcohol intoxication compared with adults, but data are lacking. A 2-month-old infant presented with a decreased mental status after accidental ingestion of alcohol. He was diagnosed with acute alcohol intoxication, with a blood alcohol level of 330 mg/dL and was hyperglycemic (167 mg/dL). Alcohol elimination rate was calculated to be 21.6 mg/dL/h, similar to that in adults. To our knowledge, this case is the second youngest documented patient with accidental alcohol intoxication via ingestion in the United States. We present a rare case report of acute alcohol intoxication in an infant and a review of the literature. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Although rare in the literature, poison control data suggests that alcohol poisoning in very young children is not rare. Emergency physicians should be prepared for the management of infants with alcohol poisoning. This case report and review brings attention to this subject and briefly discusses ethanol metabolism in infants. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Accidental childhood death and the role of the pathologist.

    Science.gov (United States)

    Byard, R W

    2000-01-01

    The following study provides an overview of accidental childhood death. This study is based on a review of 369 cases of fatal childhood accidents taken from the records of the Department of Histopathology, Women's and Children's Hospital, Adelaide, Australia, over a 34-year period from 1963 to 1996. Data provide information on deaths due to motor vehicle accidents, drownings, accidental asphyxia, burns, poisonings, electrocution, and miscellaneous trauma. In addition, certain categories have undergone further examination, including asphyxial deaths due to unsafe sleeping environments and unsafe eating practices, drowning deaths, and deaths on farms, following identification of significant child safety problems in these areas as part of the "Keeping Your Baby and Child Safe" program. Previously unrecognized dangers to children detected through this program include mesh-sided cots, V-shaped pillows, and certain types of stroller-prams. The production of information pamphlets and packages for parents and the recall of certain dangerous products following recommendations made by pathologists demonstrate that pediatric and forensic pathologists have an important role to play in preventive medicine issues and in formulating public health strategies.

  17. Pathological Findings in Accidental Electrocution in a Horse (Case Report

    Directory of Open Access Journals (Sweden)

    Adrian Florin Gal

    2016-11-01

    Full Text Available Recently, the veterinarians are dealing with a number of cases that require forensic expertise. Such a circumstance could be the accidental electrocution in animals, one of the causes of unnatural death. There is a scarcity with reference to the pathological findings in veterinary forensic medicine. In this paper, we present the main lesions that occurred in a horse with accidental electrocution that was presented for complete necropsy survey. A horse corpse was sent to the Pathology Department (Faculty of Veterinary Medicine, Cluj-Napoca, Romania for a full medical survey. Preliminary results and external examination: the body was in rigor mortis; from the nasal cavities drained out reddish foam and in the mouth was observed the presence of ingested feed (straw that was not chewed, suggesting a quick death. The findings detected after internal examination of the carcass were poor blood coagulability, haemorrhagic diathesis throughout the body, with haemorrhages of various sizes in different body regions (e.g., muscles of the withers, in the gluteal muscle, the mucosa of epiglottis, larynx, trachea, in the interstitium of the lung, and ecchymosis in the left kidney. Some other lesions detected were infarcts and haemorrhages in the fundic region of the stomach’s mucosa. In electrocution, haemorrhages are most often located in the respiratory tract, aspect observed in our case too. However, the diagnosis of electrocution has to corroborate the necropsy findings (which are not specific, with some other data such as the fulminant death and inspection of power source.

  18. accidentes y otras causas violentas en la sierra de Sonora

    Directory of Open Access Journals (Sweden)

    Héctor Eloy Rivas Sánchez

    2005-01-01

    Full Text Available Este artículo presenta los resultados de una investigación sociológica cuyo objeto fue explorar el papel que ha jugado el modelo hegemónico de masculinidad en la ocurrencia de muertes derivadas de accidentes y varias formas de ejercicio de la violencia en una comunidad rural de la sierra de Sonora. Estos resultados difieren de aquellos que tradicionalmente los estudios de las masculinidades han mostrado para México y América Latina. El modelo dominante de masculinidad en las comunidades estudiadas no ha condicionado significativamente la ocurrencia de las muertes por accidentes y otras causas violentas. La responsabilidad, la disciplina y el respeto hacia las personas consideradas socialmente débiles (mujeres, ancianos y niños, principalmente son características que debe poseer un hombre de verdad en las comunidades estudiadas. El apego de los hombres a estas formas de comportamiento y su temor a perder honorabilidad como hombre de verdad si se desvían de estas normas de conducta los ha llevado a evitar una serie de prácticas temerarias que pudieron poner en riesgo su vida y la de otras personas.

  19. Radiation myelopathy in over-irradiated patients: MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Alfonso, E.R. [Radiology Service, Hospital Clinico Universitario, Zaragoza (Spain); Gregorio, M.A. de [Radiology Service, Hospital Clinico Universitario, Zaragoza (Spain); Mateo, P. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Esco, R. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Bascon, N. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Morales, F. [Neurology Service, Hospital Clinico Universitario, Zaragoza (Spain); Bellosta, R. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Lopez, P. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Gimeno, M. [Hospital Miguel Servet, Zaragoza (Spain); Roca, M. [Radiology Service, Hospital Miguel Servet, E-50 009 Zaragoza (Spain); Villavieja, J.L. [Radiology Service, Hospital Clinico Universitario, Zaragoza (Spain)

    1997-04-01

    The objective of this work is to report the MRI findings in patients with radiation myelopathy due to accidental local over-irradiation syndrome. Eight patients (seven males and one female) were suffering from over-irradiation syndrome as a result of treatments from a malfunctioning linear electron accelerator. The mean accidental estimated dose was 136 Gy delivered to the ``open-neck`` (seven cases) and to the thoracic wall (one case), during a mean of 5.4 sessions (range 1-9 sessions). Paresthesia and weakness in the upper extremities were the earliest symptoms (87.5 %), with evolution to paralysis in all patients. No patient is alive (mean survival time 64 days). In all cases MRI was negative for neurologic lesions in the acute phase (< 90 days from irradiation; Radiation Therapy Oncology Group scoring system). Late signs of radiation myelitis manifested as high-intensity signals on T2-weighted images in three patients, and as Gd-DTPA enhancement of T1-weighted images in one case. Autopsies performed on four patients who died in acute phase showed morphologic alterations in white matter: edema in 75 %, and necrosis and glial reaction as well as obliterative vasculitis in all cases. In cases of over-irradiation, MRI may be normal in acute phase even if the patients have severe neurologic deficit, as positive MRI findings appear only in delayed radiation myelitis. (orig.). With 3 figs., 2 tabs.

  20. Mathematical model for predicting the probability of acute mortality in a human population exposed to accidentally released airborne radionuclides. Final report for Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Filipy, R.E.; Borst, F.J.; Cross, F.T.; Park, J.F.; Moss, O.R.; Roswell, R.L.; Stevens, D.L.

    1980-05-01

    A mathematical model was constructed for the purpose of predicting the fraction of human population which would die within 1 year of an accidental exposure to airborne radionuclides. The model is based on data from laboratory experiments with rats, dogs and baboons, and from human epidemiological data. Doses from external, whole-body irradiation and from inhaled, alpha- and beta-emitting radionuclides are calculated for several organs. The probabilities of death from radiation pneumonitis and from bone marrow irradiation are predicted from doses accumulated within 30 days of exposure to the radioactive aerosol. The model is compared with existing similar models under hypothetical exposure conditions. Suggestions for further experiments with inhaled radionuclides are included. 25 refs., 16 figs., 13 tabs.

  1. Two Cases of Accidental Injection of Epinephrine into a Digit Treated with Subcutaneous Phentolamine Injections

    Directory of Open Access Journals (Sweden)

    Ryan P. Bodkin

    2013-01-01

    Full Text Available Accidental injection into the digit from an epinephrine autoinjection device can cause discoloration, pain, and paresthesias. Although loss of digit is rare, treatment in the emergency department is commonly aimed at vasodilation of the affected tissue. We report two cases of accidental injection of epinephrine into the digits that were successfully treated with subcutaneous phentolamine injection with no adverse events.

  2. Involving Parents in Indicated Early Intervention for Childhood PTSD Following Accidental Injury

    Science.gov (United States)

    Cobham, Vanessa E.; March, Sonja; De Young, Alexandra; Leeson, Fiona; Nixon, Reginald; McDermott, Brett; Kenardy, Justin

    2012-01-01

    Accidental injuries represent the most common type of traumatic event to which a youth is likely to be exposed. While the majority of youth who experience an accidental injury will recover spontaneously, a significant proportion will go on to develop Post-Traumatic Stress Disorder (PTSD). And yet, there is little published treatment outcome…

  3. A novel method to detect accidental oesophageal intubation based on ventilation pressure waveforms

    NARCIS (Netherlands)

    Kalmar, Alain F.; Absalom, Anthony; Monsieurs, Koenraad G.

    2012-01-01

    Background: Emergency endotracheal intubation results in accidental oesophageal intubation in up to 17% of patients. This is frequently undetected thereby adding to the morbidity and mortality. No current method to detect accidental oesophageal intubation in an emergency setting is both highly sensi

  4. Accidental Perforation of Endotracheal Tube during Orthognathic Surgery for Maxillary Prognathism - a Case Report

    Directory of Open Access Journals (Sweden)

    Manish Jain

    2008-01-01

    Full Text Available Maxillary prognathism(excess is a congenital anomaly characterized by facial disfigurement. Accidental perforation of endotracheal tube during corrective surgery is not an uncommon complication. A case of accidental perforation of endotracheal tube during surgery and its management is presented here.

  5. Two cases of accidental injection of epinephrine into a digit treated with subcutaneous phentolamine injections.

    Science.gov (United States)

    Bodkin, Ryan P; Acquisto, Nicole M; Gunyan, Holly; Wiegand, Timothy J

    2013-01-01

    Accidental injection into the digit from an epinephrine autoinjection device can cause discoloration, pain, and paresthesias. Although loss of digit is rare, treatment in the emergency department is commonly aimed at vasodilation of the affected tissue. We report two cases of accidental injection of epinephrine into the digits that were successfully treated with subcutaneous phentolamine injection with no adverse events.

  6. [Accidental hypothermia in adults: taking charge by the SAMU of Paris].

    Science.gov (United States)

    Deny, N; Bresard, D; Bertrand, J; Poisvert, M

    1990-02-01

    Thirty one cases of accidental hypothermia have been taken in care by the SAMU de Paris during the year of 1987. The accidental hypothermias happening in the cities are, most of the time, moderated and not very serious. The search for a cause is a prime necessity. The prognosis is based on that search to guide and advise the patients.

  7. Nodular goiter after occupational accidental exposure to radiation

    Energy Technology Data Exchange (ETDEWEB)

    Pisarev, M.A. [Radiobiology, National Atomic Energy Commission, Buenos Aires (Argentina); Human Biochemistry, Uninversity of Buenos Aires, School of Medicine, Buenos Aires (Argentina); Schnitman, M. [Center of Endocrinology and Metabolism, French Hospital C.Milstein, Buenos Aires (Argentina)

    2012-07-01

    In the present paper we present the consequences of an accidental occupational radiation exposure at a local hospital in Buenos Aires. Control at a local radiology service showed the lack of correct shielding in the X-ray equipment. The physicians and technicians (14 persons) exposed to radiation during 12 months were examined. The survey shows that: a) In 11 out of 14 radiation-exposed patients nodular goiter developed and an additional patient had diffuse goiter which means a goiter incidence of 85.7%; b) In 5 of the nodular goiter patients an increase in the size or the appearance of new nodules was observed along the follow-up period. No cancer was detected by FNA; c) Hypothyroidism was observed in 3/14 patients, and an additional patient had an abnormal TRH-TSH test, suggesting subclinical hypothyroidism; and d) Increased circulating antithyroid antibodies were found in one of the hypothyroid patients

  8. Brugada syndrome unmasked by accidental inhalation of gasoline vapors

    DEFF Research Database (Denmark)

    Kranjcec, Darko; Bergovec, Mijo; Rougier, Jean-Sébastien

    2007-01-01

    Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline...... vapors. His electrocardiogram (ECG) showed a typical type-1 BrS pattern that persisted after the acute event. Genetic investigations allowed the identification of a novel SCN5A mutation leading to a frame-shift and early termination of the channel protein. Biochemical and cellular electrophysiology...... experiments confirmed the loss-of-function of the mutant allele. The patient was implanted with a cardioverter/defibrillator....

  9. Comparative toxicology of intentional and accidental heroin overdose.

    Science.gov (United States)

    Darke, Shane; Duflou, Johan; Torok, Michelle

    2010-07-01

    The demographic and toxicological characteristics of deliberate (SUI, n = 50) and accidental (ACC, n = 927) fatal heroin overdose cases were examined. SUI cases were more likely to be female, had lower body mass indices, were more likely to be enrolled in treatment and less likely to have hepatic pathology. The median blood morphine concentration of SUI cases was significantly higher than that of ACC cases (0.70 vs. 0.40 mg/L, p 1 mg/L were seen among 38.0% of SUI cases compared to 13.9% of ACC cases. Being a member of the SUI group remained a significant independent predictor of higher morphine concentrations after controlling for the effects of potential confounders (p cocaine (p overdose cases, rather than overdose being a parasuicidal phenomenon per se.

  10. Accidental intraoral formalin injection: a rare case report

    Directory of Open Access Journals (Sweden)

    Ramakant Dandriyal

    2014-12-01

    Full Text Available Formalin is a hazardous chemical that needs cautious handling and special storage. Owing to its disinfectant and fixative (i.e. for preserving pathologic tissue specimens in histopathology properties, it is widely used in dentistry. Although, the terms formaldehyde and formalin are often confused as being identical, these are different as to the concentrations of the primary component i.e. formaldehyde. In fact, the common fixative available as 10% neutral buffered formalin is actually a 4% solution of formaldehyde (i.e., a 10% solution made from a 37-40% commercially pure formaldehyde solution. This case report describes an unfortunate case of accidental injection instead of local anesthetic, of formalin into the pterygomandibular space in a 35-year old woman during inferior alveolar nerve block for surgical removal of impacted lower right third molar and its successful management by cautious debridement (under both local and general anesthesia and empirical drug therapy (utilizing analgesics and antibiotics.

  11. Accidental intraoral formalin injection: a rare case report.

    Science.gov (United States)

    Dandriyal, Ramakant; Giri, Kolly Yada; Alam, Sarwar; Singh, Aishwarya Pratap

    2014-10-30

    Formalin is a hazardous chemical that needs cautious handling and special storage. Owing to its disinfectant and fixative (i.e. for preserving pathologic tissue specimens in histopathology) properties, it is widely used in dentistry. Although, the terms formaldehyde and formalin are often confused as being identical, these are different as to the concentrations of the primary component i.e. formaldehyde. In fact, the common fixative available as 10% neutral buffered formalin is actually a 4% solution of formaldehyde (i.e., a 10% solution made from a 37-40% commercially pure formaldehyde solution). This case report describes an unfortunate case of accidental injection instead of local anesthetic, of formalin into the pterygomandibular space in a 35-year old woman during inferior alveolar nerve block for surgical removal of impacted lower right third molar and its successful management by cautious debridement (under both local and general anesthesia) and empirical drug therapy (utilizing analgesics and antibiotics).

  12. TWO-DIMENSIONAL MODELLING OF ACCIDENTAL FLOOD WAVES PROPAGATION

    Directory of Open Access Journals (Sweden)

    Lorand Catalin STOENESCU

    2011-05-01

    Full Text Available The study presented in this article describes a modern modeling methodology of the propagation of accidental flood waves in case a dam break; this methodology is applied in Romania for the first time for the pilot project „Breaking scenarios of Poiana Uzului dam”. The calculation programs used help us obtain a bidimensional calculation (2D of the propagation of flood waves, taking into consideration the diminishing of the flood wave on a normal direction to the main direction; this diminishing of the flood wave is important in the case of sinuous courses of water or with urban settlements very close to the minor river bed. In the case of Poiana Uzului dam, 2 scenarios were simulated with the help of Ph.D. Eng. Dan Stematiu, plausible scenarios but with very little chances of actually producing. The results were presented as animations with flooded surfaces at certain time steps successively.

  13. Accidental endoscopic finding of Anisakis simplex in human colon

    Directory of Open Access Journals (Sweden)

    Aurelia Aloia

    2011-09-01

    Full Text Available Anisakidosis is a zoonotic disease caused by the ingestion of nematodes belonging to the family of Anisakidae. Human infection is caused by intake of raw or undercooked sea fish and cephalopods infested by Anisakis larvae. We present a case of accidental endoscopic finding of an alive nematode adhering to distal ascending colon in a 32 years old man, submitted to colonoscopy owing to recent onsets of rectal bleeding of likely hemorrhoidal origin. The nematode, removed from colon by means of biopsy forceps, has been identified as L3 larvae of A. simplex by a light microscope. Histological examination of intestinal mucosa showed a mild fibrosis of lamina propria, characterized by focal lymphocytic inflammation and scattered infiltration of eosinophils. The patient reported the intake of marinated anchovies 3 days before endoscopic examination.

  14. Correcting for accidental correlations in saturated avalanche photodiodes.

    Science.gov (United States)

    Grieve, J A; Chandrasekara, R; Tang, Z; Cheng, C; Ling, A

    2016-02-22

    In this paper we present a general method for estimating rates of accidental coincidence between a pair of single photon detectors operated within their saturation regimes. By folding the effects of recovery time of both detectors and the detection circuit into an "effective duty cycle" we are able to accomodate complex recovery behaviour at high event rates. As an example, we provide a detailed high-level model for the behaviour of passively quenched avalanche photodiodes, and demonstrate effective background subtraction at rates commonly associated with detector saturation. We show that by post-processing using the updated model, we observe an improvement in polarization correlation visibility from 88.7% to 96.9% in our experimental dataset. This technique will be useful in improving the signal-to-noise ratio in applications which depend on coincidence measurements, especially in situations where rapid changes in flux may cause detector saturation.

  15. Dose assessment of an accidental exposure at the IPNS

    Energy Technology Data Exchange (ETDEWEB)

    Campos Torres, M.M.

    1995-02-01

    Seven different methods were used to estimate the dose rate to a female worker who was accidentally exposed in the neutron PHOENIX beamline at the IPNS. Theoretical and measured entrance dose ranged from 550 mrem/min to 2850 mrem/min. Theoretical estimates were based on a Monte Carlo simulation of a spectrum provided by IPNS (Crawford Spectrum). Dose measurements were made with TLDs on phantoms and with ionization chambers in a water phantom. Estimates of the whole body total effective dose equivalent (TEDE) rate ranged from 5.2 mrem/min to 840 mrem/min. Assumed and measured quality factors ranged from 2.6 to 11.8. Cytogenetic analyses of blood samples detected no positive exposure. The recommended TEDE rate was 158 mrem/min. The TEDE was 750 mrem.

  16. Dose assessment of an accidental exposure at IPNS

    Energy Technology Data Exchange (ETDEWEB)

    Torres, M.M.C.

    1996-05-01

    Seven different methods were used to estimate the dose rate to a female worker who was accidentally exposed in the neutron PHOENIX beamline at the IPNS. Theoretical and measured entrance dose rates ranged from 550 mrem/min to 2,850 mrem/min. Theoretical estimates were based on a Monte Carlo simulation of a spectrum provided by IPNS (Crawford Spectrum). Dose measurements were made with TLDs on phantoms and with ionization chambers in a water phantom. Estimates of the whole body total effective dose equivalent (TEDE) rate ranged from 5.2 mrem/min to 840 mrem/min. Assumed and measured quality factors ranged from 2.6 to 11.8. Cytogenic analyses of blood samples detected no positive exposure. The recommended TEDE rate was 158 mrem/min. The TEDE was 750 mrem.

  17. Genomic damage in children accidentally exposed to ionizing radiation

    DEFF Research Database (Denmark)

    Fucic, A; Brunborg, G; Lasan, R

    2007-01-01

    doses of radiation; (b) effects on children from combined exposure to low doses of radiation and chemical agents from food, water and air; and (c) specific effects from exposure during early childhood (radioisotopes from water, radon in homes). Special consideration should also be given to a possible......, environmental radiation pollution and indoor accidental contamination reveals consistently increased chromosome aberration and micronuclei frequency in exposed than in referent children. Future research in this area should be focused on studies providing information on: (a) effects on children caused by low...... of children to environmental genotoxicants. Environmental research on children predominantly investigates the health effects of air pollution while effects from radiation exposure deserve more attention. The main sources of knowledge on genome damage of children exposed to radiation are studies performed...

  18. Siquieros accidental painting technique: a fluid mechanics point of view

    CERN Document Server

    Zetina, Sandra

    2012-01-01

    This is an entry for the Gallery of Fluid Motion of the 65th Annual Meeting of the APS-DFD (fluid dynamics video). This video shows an analysis of the 'accidental painting' technique developed by D.A. Siqueiros, a famous Mexican muralist. We reproduced the technique that he used: pouring layers of paint of different colors on top of each other. We found that the layers mix, creating aesthetically pleasing patterns, as a result of a Rayleigh-Taylor instability. Due to the pigments used to give paints their color, they can have different densities. When poured on top of each other, if the top layer is denser than the lower one, the viscous gravity current undergoes unstable as it spread radially. We photograph the process and produced slowed-down video to visualize the process.

  19. Subtraction of "accidentals" and the validity of Bell tests

    CERN Document Server

    Thompson, C H

    1999-01-01

    In some key Bell experiments, including two of the well-known ones by Alain Aspect, 1981-2, it is only after the subtraction of ``accidentals'' from the coincidence counts that we get violations of Bell tests. The data adjustment, producing increases of up to 60% in the test statistics, has never been adequately justified. Few published experiments give sufficient information for the reader to make a fair assessment. There is a straightforward and well known realist model that fits the unadjusted data very well. In this paper, the logic of this realist model and the reasoning used by experimenters in justification of the data adjustment are discussed. It is concluded that the evidence from all Bell experiments is in urgent need of re-assessment, in the light of all the known ``loopholes''. Invalid Bell tests have frequently been used, neglecting an improved one derived by Clauser and Horne in 1974. ``Local causal'' explanations for the observations have been wrongfully neglected.

  20. Towards a Multimodal Methodology for the Analysis of Translated/Localised Games

    Directory of Open Access Journals (Sweden)

    Bárbara Resende Coelho

    2016-12-01

    Full Text Available Multimedia materials require research methodologies that are able to comprehend all of their assets. Videogames are the epitome of multimedia, joining image, sound, video, animation, graphics and text with the interactivity factor. A methodology to conduct research into translation and localisation of videogames should be able to analyse all of its assets and features. This paper sets out to develop a research methodology for games and their translations/localisations that goes beyond the collection and analysis of “screenshots” and includes as many of their assets as possible. Using the fully localised version of the game Watchdogs, this papers shows how tools and technologies allow for transcending the mere analysis of linguistic contents within multimedia materials. Using software ELAN Language Archive to analyse Portuguese-language dubbed and English-language subtitled excerpts from the videogame, it was possible to identify patterns in both linguistic and audio-visual elements, as well as to correlate them.

  1. Deconfinement, chiral transition and localisation in a QCD-like model

    CERN Document Server

    Giordano, Matteo; Kovacs, Tamas G; Pittler, Ferenc

    2016-01-01

    We study the problems of deconfinement, chiral symmetry restoration and localisation of the low Dirac eigenmodes in a toy model of QCD, namely unimproved staggered fermions on lattices of temporal extension $N_T=4$. This model displays a genuine deconfining and chirally-restoring first-order phase transition at some critical value of the gauge coupling. Our results indicate that the onset of localisation of the lowest Dirac eigenmodes takes place at the same critical coupling where the system undergoes the first-order phase transition. This provides further evidence of the close relation between deconfinement, chiral symmetry restoration and localisation of the low modes of the Dirac operator on the lattice.

  2. Neuromorphic Audio-Visual Sensor Fusion on a Sound-Localising Robot

    Directory of Open Access Journals (Sweden)

    Vincent Yue-Sek Chan

    2012-02-01

    Full Text Available This paper presents the first robotic system featuring audio-visual sensor fusion with neuromorphic sensors. We combine a pair of silicon cochleae and a silicon retina on a robotic platform to allow the robot to learn sound localisation through self-motion and visual feedback, using an adaptive ITD-based sound localisation algorithm. After training, the robot can localise sound sources (white or pink noise in a reverberant environment with an RMS error of 4 to 5 degrees in azimuth. In the second part of the paper, we investigate the source binding problem. An experiment is conducted to test the effectiveness of matching an audio event with a corresponding visual event based on their onset time. The results show that this technique can be quite effective, despite its simplicity.

  3. Characterization and Comparison of Injuries Caused by Accidental and Non-accidental Blunt Force Trauma in Dogs and Cats.

    Science.gov (United States)

    Intarapanich, Nida P; McCobb, Emily C; Reisman, Robert W; Rozanski, Elizabeth A; Intarapanich, Pichai P

    2016-07-01

    Motor vehicle accidents (MVA) are often difficult to distinguish from non-accidental injury (NAI). This retrospective case-control study compared animals with known MVA trauma against those with known NAI. Medical records of 426 dogs and cats treated after MVA and 50 after NAI were evaluated. Injuries significantly associated with MVA were pelvic fractures, pneumothorax, pulmonary contusion, abrasions, and degloving wounds. Injuries associated with NAI were fractures of the skull, teeth, vertebrae, and ribs, scleral hemorrhage, damage to claws, and evidence of older fractures. Odds ratios are reported for these injuries. MVA rib fractures were found to occur in clusters on one side of the body, with cranial ribs more likely to fracture, while NAI rib fractures were found to occur bilaterally with no cranial-caudal pattern. Establishing evidence-based patterns of injury may help clinicians differentiate causes of trauma and may aid in the documentation and prosecution of animal abuse. © 2016 American Academy of Forensic Sciences.

  4. FACTORES DE RIESGO QUE OCASIONAN ACCIDENTES LABORALES EN EL PERSONAL DE ENFERMERÍA DE UNA CLÍNICA ACREDITADA DE LA CIUDAD DE AREQUIPA, 2007-2008

    OpenAIRE

    GARCIA SUTTA, PATRICIA CONCEPCION

    2014-01-01

    FACTORES DE RIESGO CONCEPTUALIZACIÓN TIPOS RIESGOS NO MECÁNICOS RUIDOS RADIACIONES IONIZANTES ILUMINACIÓN CALOR FRÍO RIESGOS FÍSICOS MECÁNICOS RIESGOS QUÍMICOS RIESGOS ERGONÓMICOS POSTURA RIESGOS BIOLÓGICOS CARGA DE TRABAJO LABORAL DEFINICIÓN ACCIDENTES LABORALES ACCIDENTE CAUSAS BÁSICAS Y CAUSAS INMEDIATAS ACCIDENTES LABORALES CAUSAS DE LOS ACCIDENTES TIPOS DE ACCIDENTE TIPOS DE ACCIDENTES LABORALES

  5. FACTORES DE RIESGO QUE OCASIONAN ACCIDENTES LABORALES EN EL PERSONAL DE ENFERMERÍA DE UNA CLÍNICA ACREDITADA DE LA CIUDAD DE AREQUIPA, 2007-2008

    OpenAIRE

    GARCIA SUTTA, PATRICIA CONCEPCION

    2014-01-01

    FACTORES DE RIESGO CONCEPTUALIZACIÓN TIPOS RIESGOS NO MECÁNICOS RUIDOS RADIACIONES IONIZANTES ILUMINACIÓN CALOR FRÍO RIESGOS FÍSICOS MECÁNICOS RIESGOS QUÍMICOS RIESGOS ERGONÓMICOS POSTURA RIESGOS BIOLÓGICOS CARGA DE TRABAJO LABORAL DEFINICIÓN ACCIDENTES LABORALES ACCIDENTE CAUSAS BÁSICAS Y CAUSAS INMEDIATAS ACCIDENTES LABORALES CAUSAS DE LOS ACCIDENTES TIPOS DE ACCIDENTE TIPOS DE ACCIDENTES LABORALES

  6. Systematic Characterisation of Cellular Localisation and Expression Profiles of Proteins Containing MHC Ligands

    DEFF Research Database (Denmark)

    Juncker, Agnieszka; Larsen, Mette Voldby; Weinhold, Nils

    2009-01-01

    that most proteins containing MHC class I ligands were localised to the intracellular parts of the cell including the cytoplasm and nucleus. MHC class II ligand donors were, on the other hand, mostly membrane proteins. Conclusions/Significance: The results contribute to the ongoing debate concerning...... the nature of MHC ligand-containing proteins and can be used to extend the existing methods for MHC ligand predictions by including the source protein's localisation and expression profile. Improving the current methods is important in the growing quest for epitopes that can be used for vaccine or diagnostic...

  7. Strain localisation in mechanically layered rocks beneath detachment zones: insights from numerical modelling

    Directory of Open Access Journals (Sweden)

    L. Le Pourhiet

    2013-04-01

    Full Text Available We have designed a series of fully dynamic numerical simulations aimed at assessing how the orientation of mechanical layering in rocks controls the orientation of shear bands and the depth of penetration of strain in the footwall of detachment zones. Two parametric studies are presented. In the first one, the influence of stratification orientation on the occurrence and mode of strain localisation is tested by varying initial dip of inherited layering in the footwall with regard to the orientation of simple shear applied at the rigid boundary simulating a rigid hanging wall, all scaling and rheological parameter kept constant. It appears that when Mohr–Coulomb plasticity is being used, shear bands are found to localise only when the layering is being stretched. This corresponds to early deformational stages for inital layering dipping in the same direction as the shear is applied, and to later stages for intial layering dipping towards the opposite direction of shear. In all the cases, localisation of the strain after only γ=1 requires plastic yielding to be activated in the strong layer. The second parametric study shows that results are length-scale independent and that orientation of shear bands is not sensitive to the viscosity contrast or the strain rate. However, decreasing or increasing strain rate is shown to reduce the capacity of the shear zone to localise strain. In the later case, the strain pattern resembles a mylonitic band but the rheology is shown to be effectively linear. Based on the results, a conceptual model for strain localisation under detachment faults is presented. In the early stages, strain localisation occurs at slow rates by viscous shear instabilities but as the layered media is exhumed, the temperature drops and the strong layers start yielding plastically, forming shear bands and localising strain at the top of the shear zone. Once strain localisation has occured, the deformation in the shear band becomes

  8. How active ingredient localisation in plant tissues determines the targeted pest spectrum of different chemistries

    DEFF Research Database (Denmark)

    Buchholz, Anke; Trapp, Stefan

    2016-01-01

    information sets revealed that the intracellular localisation of active ingredients determines the performance of test compounds against different target pests because of different feeding behaviours: mites feed on mesophyll, and aphids and whiteflies mostly in the vascular system. Polar compounds have a slow...... adsorption into leaf cells and thus a favourable distribution into apoplast and xylem sap. Slightly lipophilic bases get trapped in vacuoles, which is a less suited place to control hemipteran pests but appropriate to control mites. Non-favourable cellular localisation led to a strong reduction...

  9. Accidental Children Poisoning With Methadone: An Iranian Pediatric Sectional Study

    Directory of Open Access Journals (Sweden)

    Sayena JABBEHDARI

    2013-11-01

    Full Text Available How to Cite This Article: Jabbehdari S, Farnaghi F, Shariatmadari SF, Jafari J, Mehregan FF, Karimzadeh P. Accidental Children Poisoning With Methadone: An Iranian Pediatric Sectional Study. Iran J Child Neurol. 2013 Autumn;7(7: 32-34.ObjectiveToxic poisoning with methadone is common in children in Iran. Our study was carried out due to the changing pattern of methadone poisoning in recent years and increasing methadone toxicity. Materials & MethodsIn this descriptive-sectional study, all of the methadone poisoned children younger than 12 years who were admitted to the Loghman Hakim Hospital in 2012, were assessed. Clinical symptoms and signs, para-clinical findings, and treatment were evaluated. ResultsIn this study, 16 boys and 15 girls who had been poisoned by methadone were enrolled. The mean age of patients was 55 months. All patients had been poisoned randomly or due to parent’s mistakes. The mean time of symptoms onset after methadone consumption was 1 hour and 30 Min, indicating a relatively long time after onset of symptoms.Clinical findings were drowsiness (75%, miotic pupil (68 %, vomiting (61%, rapid shallow breathing (57% and apnea (40%. In paraclinical tests, respiratory acidosis (69% and leukocytosis (55.2% were seen. The most important finding was increase in distance of QT in ECG (23.8%. The mean time of treatment with naloxone infusion was 51 hours. Three percent of patients had a return of symptoms after discontinuation of methadone. In patients with apnea, a longer course of treatment was required, and this difference was significant. Also, 17% of patients with apnea had aspiration pneumonia, which was statistically significant. ConclusionWe suggest long time treatment with naloxone and considering the probability of return of symptoms after discontinuation of methadone.ReferencesGoldfrank L, Flomenbaum N, Lewin N. Goldfrank’s Toxicologic Emergencies. 7th ed. McGraw–Hill 2002; p. 590-607.Schelble DT. Phosgene and

  10. The Frequency of the Accidental Contamination with Laboratory Samples in Yazd Clinical Laboratories’ personnel in 2011

    Directory of Open Access Journals (Sweden)

    Jafari, AA. (PhD

    2014-05-01

    Full Text Available Background and Objective: laboratory personnel have always accidental exposure to clinical samples, which can cause the transmission of infection. This threat can be prevented and controlled by education for the use of safety instruments. The purpose was to determine the frequency of accidental exposure to laboratory samples among Yazd laboratory personnel in 2011. Material and Methods: This descriptive cross-sectional study was conducted on 100 of Yazd clinical laboratory personnel. The data was collected, using a valid and reliable questioner, via interview and analyzed by means of SPSS software. Results: Eighty-six percent of the subjects reported an experience of accidental exposure to clinical samples, such as blood, serum and urine. The causes were carelessness (41% and work overload (29%. Needle- stick was the most prevalent injury (52% particularly in sampler workers (51% and in their hands (69%. There wasn’t significant relationship between accidental exposure to laboratory samples and the variables such as private and governmental laboratories (p=0.517, kind of employment (p=0.411, record of services (p=0.439 and academic degree (p=0.454. The subjects aged 20-29 (p=0.034 and worked in sampling unit had the highest accidental exposure. Conclusion: based on the results, inexperience of the personnel especially in sampling room, overload at work and ignorance of applying safety instruments are known as the most important reasons for accidental exposure to clinical samples. Keywords: Contamination; accidental Exposure; Infectious agents; laboratory; personnel

  11. The use of a metal detector for localisation of a metallic foreign body in the floor of the mouth.

    Science.gov (United States)

    Moore, U J; Fanibunda, K; Gross, M J

    1993-06-01

    The case illustrates the valuable assistance provided by a metal detector in localising an elusive broken instrument which was hidden in a recess on the medial side of the mandibular angle and encapsulated in fibrous tissue. A relative degree of sophistication built into the detector aided early localisation.

  12. Comparative analysis of cell populations involved in the proliferative and inflammatory processes in diffuse and localised pigmented villonodular synovitis.

    Science.gov (United States)

    Berger, I; Ehemann, V; Helmchen, B; Penzel, R; Weckauf, H

    2004-07-01

    The aim of the present study was a comparative quantitative evaluation of cell populations involved in the proliferative and inflammatory compartment in both localised and diffuse pigmented synovitis villonodularis (PVNS). 15 cases of each localised and diffuse PVNS were examined by flow cytometry, immunohistochemistry, double immuno-fluorescence and confocal microscopy with quantitative evaluation of CD3-, CD4-, CD8-, CD20-, CD57-, CD55-, CD68-, CD163- and h4Ph positive (+) cells. The proliferative compartment of localised and diffuse PVNS was mainly composed of double-positive CD68+/h4Ph+ (CD163+/CD55+) synoviocytes. The number of double-positive synoviocytes for macrophage and fibroblast markers was significantly higher in diffuse compared to localised PVNS. The accompanying inflammatory infiltrate showed a predominance of cytotoxic cells (CD8+, CD57+), whereby the number of CD3+ and CD20+ cells was significantly higher in localised PVNS. The number of CD57+ NK cells was significantly higher in diffuse PVNS. The proliferating macrophage- like synovial cells and the cytotoxic lymphocytes could contribute to the aggressive behaviour of localised and diffuse PVNS. Moreover, with regard to the quantitative differences in cell composition between diffuse and localised PVNS and their different clinical behaviour, further studies should continue to analyse localised and diffuse PVNS separately.

  13. La prevención de accidentes (2

    Directory of Open Access Journals (Sweden)

    Chinchilla, M.

    1966-03-01

    Full Text Available Everyone prefers to work in those organizations where their dignity of human beings is respected. One of the most efficient means at the disposal of any firm, to improve the morale of the individual employees, and to establish a spirit of cooperation between the individual and the firm, is to set up a program of accident benefit. It will avoid direct and indirect losses due to working accidents, as analyzed in a previous article, and it will make it possible to improve total performance of each worker, since he will work in a more favorable environment, free from worry about potential danger to his person. It is almost impossible to describe in detail all those items that should be taken into account in a safety program. None the less, and as an indication of their diversity, some sources of danger are mentioned in this chapter, which are closely connected with human safety, such as public curiosity, travelling from one place to another, cleanliness and order.Todas las personas prefieren desempeñar sus tareas en aquellas organizaciones que tienen hacia ellos las consideraciones correspondientes a un ser humano. Uno de los medios más eficaces a disposición de cualquier empresa para elevar la moral del individuo y para crear un lazo de cooperación común entre el individuo y la empresa, es la de llevar a cabo un programa de prevención de accidentes, programa que redundará en el doble fruto: evitar las pérdidas directas e indirectas causadas por los accidentes de trabajo que se detallaron en un trabajo anterior, y conseguir aumentar el rendimiento del operario al hacerle un ambiente más grato por la preocupación que se demuestra hacia su persona. Es casi imposible detallar todos aquellos puntos que se deben tener en cuenta en un programa de seguridad; sin embargo, y como exponente de su diversidad, se señalan en este capítulo algunas causas, que, sin estar ligadas directamente con el trabajo individual, no obstante se encuentran

  14. Factores de riesgo asociados a los accidentes en el hogar

    Directory of Open Access Journals (Sweden)

    Lidia Arlaes Yero

    1998-12-01

    Full Text Available Se realizó un estudio analítico retrospectivo (caso-control sobre accidentes en el hogar ocurridos en la población de dos consultorios de médicos de familia del área centro en el municipio Sancti Spiritus, durante el año 1996. Se tuvo en cuenta la ocurrencia de estos eventos en la población general, la incidencia estuvo representada por 77 casos y se escogió como grupo control el resto de la población. Como resultado se observó que los accidentes del hogar (AH son más frecuentes en mujeres en edades avanzadas, con una distribución temporal mayor en el cuarto trimestre del año. Los AH fueron más frecuentes en los individuos que ingieren psicofármacos en las edades extremas de la vejez. El horario de ocurrencia más frecuente fue el de la tarde; y los lugares, la cocina y el patio. Como tipo de lesión predominó la contusión y la herida. Se concluyó además que la presencia de factores predisponentes constituyen riesgo de gran magnitud en la aparición de los AHAn analytical retrospective study (case-control about home accidents occurred among the population of 2 family physician’s offices in the central area of the municipality of Sancti Spiritus, during 1996, was conducted. The occurrence of such events in the general population was taken into account. Incidence was represented by 77 cases and the rest of the population was chosen as a control group. As a result, it was observed that home accidents were more frequent in aged women, with a greater temporary distribution in the fourth trimester of the year. Home accidents took place more frequently in those individuals taking psychotropic drugs a extreme advanced ages. Most of the accidents occurred in the afternoon, and the kitchen and the backyard were the commonest places. Contusions and wounds were the predominant injuries. It was concluded that the presence of predisposing factors is a high risk for the occurrence of home accidents

  15. Kebab: kinetochore and EB1 associated basic protein that dynamically changes its localisation during Drosophila mitosis.

    Science.gov (United States)

    Meireles, Ana M; Dzhindzhev, Nikola S; Ohkura, Hiroyuki

    2011-01-01

    Microtubule plus ends are dynamic ends that interact with other cellular structures. Microtubule plus end tracking proteins are considered to play important roles in the regulation of microtubule plus ends. Recent studies revealed that EB1 is the central regulator for microtubule plus end tracking proteins by recruiting them to microtubule plus ends through direct interaction. Here we report the identification of a novel Drosophila protein, which we call Kebab (kinetochore and EB1 associated basic protein), through in vitro expression screening for EB1-interacting proteins. Kebab fused to GFP shows a novel pattern of dynamic localisation in mitosis. It localises to kinetochores weakly in metaphase and accumulates progressively during anaphase. In telophase, it associates with microtubules in central-spindle and centrosomal regions. The localisation to kinetochores depends on microtubules. The protein has a domain most similar to the atypical CH domain of Ndc80, and a coiled-coil domain. The interaction with EB1 is mediated by two SxIP motifs but is not required for the localisation. Depletion of Kebab in cultured cells by RNA interference did not show obvious defects in mitotic progression or microtubule organisation. Generation of mutants lacking the kebab gene indicated that Kebab is dispensable for viability and fertility.

  16. In vivo fluorescence kinetics and localisation of aluminium phthalocyanine disulphonate in an autologous tumour model

    NARCIS (Netherlands)

    Witjes, MJH; Speelman, OC; Nikkels, PGJ; Nooren, CAAM; Nauta, JM; vanderHolt, B; vanLeengoed, HLLM; Roodenburg, JLN

    1996-01-01

    Sulphonated phthalocyanines are studied as photosensitisers for photodynamic therapy of cancer. Their strong fluorescence and tumour-localising properties make them also potentially useful for detection of cancer by fluorescence. For this purpose, we have studied the fluorescence kinetics and locali

  17. A machine-hearing system exploiting head movements for binaural sound localisation in reverberant conditions

    DEFF Research Database (Denmark)

    May, Tobias; Ma, Ning; Wierstorf, Hagen;

    2015-01-01

    This paper is concerned with machine localisation of multiple active speech sources in reverberant environments using two (binaural) microphones. Such conditions typically present a problem for ‘classical’ binaural models. Inspired by the human ability to utilise head movements, the current study...

  18. Kyste hydatique pulmonaire: double localisation pulmonaire apicale inhabituelle. A propos d’un cas

    Science.gov (United States)

    Sajiai, Hafsa; Rachidi, Mariam; Aitbatahar, Salma; Serhane, Hind; Amro, Lamyae

    2016-01-01

    Le kyste hydatique (KH) est une pathologie encore endémique dans plusieurs pays notamment dans notre contexte marocain. L’atteinte pulmonaire vient au second plan après l’atteinte hépatique. Elle se caractérise par la richesse des tableaux anotomo-cliniques et la possibilité de localisations multiples dans le parenchyme pulmonaire, prédominant essentiellement aux bases. Nous rapportons le cas de Mr J.M, âgé de 54 ans, admis pour suspicion de kyste hydatique pulmonaire devant une douleur thoracique évoluant depuis 6 mois et un épisode d’hydatidoptysie. La radiographie thoracique a objectivé une image particulière de double localisation apicale illustrant en un même cliché des différents stades évolutifs du kyste hydatique pulmonaire. Le diagnostic était confirmé par la TDM thoracique et la sérologie hydatique. La localisation multiple du kyste hydatique pulmonaire n’est pas une situation rare dans les pays à forte endémie hydatique. Notre cas clinique rapporte une double localisation apicale inhabituelle du kyste hydatique et à des stades évolutifs différents. PMID:28292121

  19. Wavelet Transform Based Multifractal Formalism in Outlier Detection and Localisation for Financial Time Series

    NARCIS (Netherlands)

    Z.R. Struzik; A.P.J.M. Siebes (Arno)

    2002-01-01

    textabstractWe present a method of detecting and localising outliers in financial time series and other stochastic processes. The method checks the internal consistency of the scaling behaviour of the process within the paradigm of the multifractal spectrum. Deviation from the expected spectrum is i

  20. Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2

    NARCIS (Netherlands)

    Ruane, Peter T; Gumy, Laura F|info:eu-repo/dai/nl/337608334; Bola, Becky; Anderson, Beverley; Wozniak, Marcin J; Hoogenraad, Casper C|info:eu-repo/dai/nl/227263502; Allan, Victoria J

    2016-01-01

    Microtubules and their associated proteins (MAPs) underpin the polarity of specialised cells. Adenomatous polyposis coli (APC) is one such MAP with a multifunctional agenda that requires precise intracellular localisations. Although APC has been found to associate with kinesin-2 subfamily members,

  1. Quantum resonance, Anderson localisation and selective rotational excitation in periodically kicked molecules

    Directory of Open Access Journals (Sweden)

    Averbukh I. Sh.

    2013-03-01

    Full Text Available We show that molecules kicked periodically by laser pulses currently used in molecular alignment experiments allow to observe effects of the periodically kicked quantum rotor in a real rotational system. Among these effects are Anderson localisation in angular momentum and the scaling of the quantum resonance. Based on this, we propose a new scheme for selective molecular rotational excitation.

  2. Characterisation of a novel proteolytic enzyme localised to goblet cells in rat and man

    DEFF Research Database (Denmark)

    Poulsen, Steen Seier

    1984-01-01

    A proteolytic enzyme, ingobsin , purified from rat duodenal extracts is shown to be localised to intestinal goblet cells of both man and rat. Enzyme positive cells decrease in number from duodenum to colon. The enzyme is a 33 000 Mr protein with an isoelectric point of 5.1. The pH optimum...

  3. Exploiting deep neural networks and head movements for binaural localisation of multiple speakers in reverberant conditions

    DEFF Research Database (Denmark)

    Ma, Ning; Brown, Guy J.; May, Tobias

    2015-01-01

    This paper presents a novel machine-hearing system that exploits deep neural networks (DNNs) and head movements for binaural localisation of multiple speakers in reverberant conditions. DNNs are used to map binaural features, consisting of the complete crosscorrelation function (CCF) and interaural...... acoustic scenarios in which multiple speakers and room reverberation are present....

  4. Growth patterns in Onychophora (velvet worms: lack of a localised posterior proliferation zone

    Directory of Open Access Journals (Sweden)

    Landman Kerry A

    2010-11-01

    Full Text Available Abstract Background During embryonic development of segmented animals, body segments are thought to arise from the so-called "posterior growth zone" and the occurrence of this "zone" has been used to support the homology of segmentation between arthropods, annelids, and vertebrates. However, the term "posterior growth zone" is used ambiguously in the literature, mostly referring to a region of increased proliferation at the posterior end of the embryo. To determine whether such a localised posterior proliferation zone is an ancestral feature of Panarthropoda (Onychophora + Tardigrada + Arthropoda, we examined cell division patterns in embryos of Onychophora. Results Using in vivo incorporation of the DNA replication marker BrdU (5-bromo-2'-deoxyuridine and anti-phospho-histone H3 immunolabelling, we found that a localised posterior region of proliferating cells does not occur at any developmental stage in onychophoran embryos. This contrasts with a localised pattern of cell divisions at the posterior end of annelid embryos, which we used as a positive control. Based on our data, we present a mathematical model, which challenges the paradigm that a localised posterior proliferation zone is necessary for segment patterning in short germ developing arthropods. Conclusions Our findings suggest that a posterior proliferation zone was absent in the last common ancestor of Onychophora and Arthropoda. By comparing our data from Onychophora with those from annelids, arthropods, and chordates, we suggest that the occurrence of a "posterior growth zone" currently cannot be used to support the homology of segmentation between these three animal groups.

  5. An Efficient Approach for Node Localisation and Tracking in Wireless Sensor Networks

    CSIR Research Space (South Africa)

    Mwila, Martin K

    2014-08-01

    Full Text Available to construct a variety of cheap and efficient sensors. Sensors like accelerometer and magnetic compass are embedded in most modern wireless devices and can be combined with existing methods to increase accuracy of and efficiency of the localisation process...

  6. Empirical performance of RSSI-based Monte Carlo localisation for active RFID patient tracking systems

    NARCIS (Netherlands)

    Cully, William P.L.; Cotton, Simon L.; Scanlon, W.G.

    2012-01-01

    The range of potential applications for indoor and campus based personnel localisation has led researchers to create a wide spectrum of different algorithmic approaches and systems. However, the majority of the proposed systems overlook the unique radio environment presented by the human body

  7. Localisation of Sensor Nodes with Hybrid Measurements in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Muhammad W. Khan

    2016-07-01

    Full Text Available Localisation in wireless networks faces challenges such as high levels of signal attenuation and unknown path-loss exponents, especially in urban environments. In response to these challenges, this paper proposes solutions to localisation problems in noisy environments. A new observation model for localisation of static nodes is developed based on hybrid measurements, namely angle of arrival and received signal strength data. An approach for localisation of sensor nodes is proposed as a weighted linear least squares algorithm. The unknown path-loss exponent associated with the received signal strength is estimated jointly with the coordinates of the sensor nodes via the generalised pattern search method. The algorithm’s performance validation is conducted both theoretically and by simulation. A theoretical mean square error expression is derived, followed by the derivation of the linear Cramer-Rao bound which serves as a benchmark for the proposed location estimators. Accurate results are demonstrated with 25%–30% improvement in estimation accuracy with a weighted linear least squares algorithm as compared to linear least squares solution.

  8. In vivo fluorescence kinetics and localisation of aluminium phthalocyanine disulphonate in an autologous tumour model

    NARCIS (Netherlands)

    Witjes, MJH; Speelman, OC; Nikkels, PGJ; Nooren, CAAM; Nauta, JM; vanderHolt, B; vanLeengoed, HLLM; Roodenburg, JLN

    1996-01-01

    Sulphonated phthalocyanines are studied as photosensitisers for photodynamic therapy of cancer. Their strong fluorescence and tumour-localising properties make them also potentially useful for detection of cancer by fluorescence. For this purpose, we have studied the fluorescence kinetics and locali

  9. Kebab: kinetochore and EB1 associated basic protein that dynamically changes its localisation during Drosophila mitosis.

    Directory of Open Access Journals (Sweden)

    Ana M Meireles

    Full Text Available Microtubule plus ends are dynamic ends that interact with other cellular structures. Microtubule plus end tracking proteins are considered to play important roles in the regulation of microtubule plus ends. Recent studies revealed that EB1 is the central regulator for microtubule plus end tracking proteins by recruiting them to microtubule plus ends through direct interaction. Here we report the identification of a novel Drosophila protein, which we call Kebab (kinetochore and EB1 associated basic protein, through in vitro expression screening for EB1-interacting proteins. Kebab fused to GFP shows a novel pattern of dynamic localisation in mitosis. It localises to kinetochores weakly in metaphase and accumulates progressively during anaphase. In telophase, it associates with microtubules in central-spindle and centrosomal regions. The localisation to kinetochores depends on microtubules. The protein has a domain most similar to the atypical CH domain of Ndc80, and a coiled-coil domain. The interaction with EB1 is mediated by two SxIP motifs but is not required for the localisation. Depletion of Kebab in cultured cells by RNA interference did not show obvious defects in mitotic progression or microtubule organisation. Generation of mutants lacking the kebab gene indicated that Kebab is dispensable for viability and fertility.

  10. Empirical performance of RSSI-based Monte Carlo localisation for active RFID patient tracking systems

    NARCIS (Netherlands)

    Cully, William P.L.; Cotton, Simon L.; Scanlon, William G.

    2012-01-01

    The range of potential applications for indoor and campus based personnel localisation has led researchers to create a wide spectrum of different algorithmic approaches and systems. However, the majority of the proposed systems overlook the unique radio environment presented by the human body leadin

  11. Application of a Null-Beamformer to Source Localisation in MEG Data of Deep Brain Stimulation

    DEFF Research Database (Denmark)

    Mohseni, Hamid R.; Kringelbach, Morten L.; Smith, Penny Probert;

    2010-01-01

    to reconstruct the neural activity of interest is challenging because of interference to the signal from the DBS device. We demonstrate that a null-beamformer can be used to localise neural activity despite artefacts caused by the presence of DBS electrodes and stimulus pulses. We subsequently verified...

  12. Globalisation and Localisation in Music Education in Hong Kong and Taiwan

    Science.gov (United States)

    Ho, Wai-Chung

    2013-01-01

    The purpose of the study is to analyse and discuss the influences of globalisation and localisation on music education in Hong Kong and Taiwan. It argues that the reform of music education concerns changes to the contents of the curriculum that envisage the cultural and political developments that arise from processes of globalisation and…

  13. Funciones superiores en pacientes con accidente cerebro vascular.

    Directory of Open Access Journals (Sweden)

    Felipe Rodríguez

    2009-07-01

    Full Text Available Los estudios realizados en Chile hasta la fecha no permiten detectar de manera significativa el deterioro neuropsicológico causado por el accidente cerebro vascular (ACV y el impacto que éste tiene en el paciente a nivel de su desenvolvimiento diario y familiar. Con base a esto el objetivo de esta investigación fue elaborar un perfil de deterioro neuropsicológico de las diversas funciones cerebrales superiores causado por un ACV, en un grupo de 50 pacientes de la Unidad de Medicina Física del Hospital San José al cuál se le administró un Protocolo de Evaluación Neuropsicológica, comparándose luego con un grupo control de 50 sujetos evaluados con el mismo protocolo. Se encuentra que sobre un 20% de la población con ACV evaluada presenta deterioro en al menos uno de los ítems evaluados, siendo las funciones ejecutivas, la memoria a largo plazo y la memoria a corto plazo las áreas mayoritariamente afectada en la población evaluada.

  14. Individual dose due to radioactivity accidental release from fusion reactor.

    Science.gov (United States)

    Nie, Baojie; Ni, Muyi; Wei, Shiping

    2017-04-05

    As an important index shaping the design of fusion safety system, evaluation of public radiation consequences have risen as a hot topic on the way to develop fusion energy. In this work, the comprehensive public early dose was evaluated due to unit gram tritium (HT/HTO), activated dust, activated corrosion products (ACPs) and activated gases accidental release from ITER like fusion reactor. Meanwhile, considering that we cannot completely eliminate the occurrence likelihood of multi-failure of vacuum vessel and tokamak building, we conservatively evaluated the public radiation consequences and environment restoration after the worst hypothetical accident preliminarily. The comparison results show early dose of different unit radioactivity release under different conditions. After further performing the radiation consequences, we find it possible that the hypothetical accident for ITER like fusion reactor would result in a level 6 accident according to INES, not appear level 7 like Chernobyl or Fukushima accidents. And from the point of environment restoration, we need at least 69 years for case 1 (1kg HTO and 1000kg dust release) and 34-52years for case 2 (1kg HTO and 10kg-100kg dust release) to wait the contaminated zone drop below the general public safety limit (1mSv per year) before it is suitable for human habitation.

  15. Tratamiento endovascular del accidente vascular encefálico agudo

    Directory of Open Access Journals (Sweden)

    Dr. G. Francisco Mena

    2013-01-01

    Full Text Available La alternativa de terapia neuroendovascular para un tratamiento del accidente vascular encefálico agudo es una área de la medicina en rápida expansión. El rescate endovascular del infarto cerebral agudo tiene como principal objetivo la rápida reperfusión del vaso ocluido utilizando la trombolisis intra-arterial cerebral y distintos métodos de trombectomía mecánica o colocación permanente de neurostent. El tratamiento neuro-endovascular de la hemorragia subaracnoidea aguda aneurismática también se ha establecido como la terapia de elección e incluye la embolización convencional con coils del aneurisma cerebral roto o utilizando técnica de embolización balón o stent asistido o colocación primaria de stent con tecnología de divertidor de flujo. Además, con la terapia endovascular se puede efectuar angioplastía farmacológica y mecánica del vasoespasmo cerebral.

  16. Learning From Biomarkers in Victims Accidentally Exposed to Ionizing Radiation

    Institute of Scientific and Technical Information of China (English)

    Yan Wang; Liqing Du; Chang Xu; Qin Wang; Zhiyi Song; Jianxiang Liu; Xu Su

    2016-01-01

    Biomarkers,such as chromosome aberration and micronuclei assays,prove to be reliable for facilitating clinical diagnosis in radiation accidents.In a radiation accident in India,chromosomal aberration,γ-H2AX,as well as other blood markers,were detected in accidentally exposed victims.This multi-parametric approach aided in confirming that individuals had been exposed by ionizing radiation.However,doses were impossible to estimate because of a 30-day delay in accident awareness.Exposure dose for victims was estimated using a dose-response curve previously established.Dose estimation,blood cell depletion kinetics,and no appearance of prodromal symptoms suggested that doses of exposure were low.Hematologic investigation,sampling time,and chromosome aberration scoring were all proposed according to data from the victims exposed to 60Co.Finally,knowledge regarding chromosome aberration analysis and the importance of international co-operation and assistance should be shared from this accident.

  17. Accidental deaths caused by electricity in Sweden, 1975-2000.

    Science.gov (United States)

    Lindström, Richard; Bylund, Per-Olof; Eriksson, Anders

    2006-11-01

    This study analyzes accidental fatalities caused by electricity--at work and during leisure time--to evaluate risk factors, the role of alcohol, and to identify possible preventive strategies. In Sweden, data on fatalities by electrocution from 1975 through 2000 were collected from the National Cause-of-Death Register. Additional cases were found in the archives of The Swedish National Electrical Safety Board. Suicides and deaths by lightning were excluded. Two hundred and eighty-five deaths were found, including occupational (n=132), leisure time (n=151), and unknown (n=2). Most deaths were caused by aerial power lines, and the most common place for an electrical injury was a railway area or residential property. Postmortem blood from 20% (n=47) of the tested cases was found positive for alcohol, and these persons were killed mainly during leisure time. During the study period, the overall incidence of electricity-related fatalities has decreased, in spite of increased use of electricity. This indicates that safety improvements have been successful.

  18. Pre-accidental situations highlighted by RECUPERARE method and data

    Energy Technology Data Exchange (ETDEWEB)

    Matahri, N. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France)

    2006-07-01

    RECUPERARE method has been developed for operating feedback analysis and built on the French Human Reliability Analysis (HRA) principles. It is used to study the causes of human errors or technical failures occurred in French PWRs and the recovery process of events. Based on an event classification (6 categories) model according to the nature of the link between failure and recovery, the identified and recorded data are: the causes of the defects (technical, human, organizational) and the context in which they appear; the factors of the recovery performance (depending on technical and organizational aspects); a chronological analysis, designed to collect delays between failures and their detection/recovery for each event. About 3600 events reported in French PWRs (1997-2003) had been reviewed through this model. Initially, the weight of factors and the most important factors, which influenced the detection and recovery delay, are defined. For this purpose, the regression Partial Least Square (PLS) is used. Then, to link RECUPERARE results with pre-accidental data, conditional probabilities of events linked between them by a cause and effect relationship are calculated. For this, the Bayesian method with the Bayesian network is built with the PLS obtained results and applied. This constitutes a first approach to take into account in HRA the human and organizational factors highlighted by operating feedback. (author)

  19. Calidad de vida de cuidadores de adultos con accidente cerebrovascular

    Directory of Open Access Journals (Sweden)

    INNA ELIDA FLÓREZ TORRES

    2010-10-01

    Full Text Available Objetivo: describir la calidad de vida de los cuidadores familiares de adultos con secuelas de accidente cerebrovascular, en Cartagena, Colombia. Método: estudio descriptivo cuantitativo realizado durante el segundo semestre de 2008. Muestra no probabilística por conveniencia de 97 cuidadores. Se empleó el instrumento propuesto por Ferrell et ál. Para valorar cada uno de los bienestares que integran la calidad de vida se utilizaron medidas de tendencia central y coeficiente de variación. Resultados: el grupo de cuidadores presentó en el bienestar físico un promedio de 11,1 con relación al máximo puntaje, lo que indica el peor estado de salud; los bienestares psicológico y social tuvieron promedios de 48,8 y 21,9, respectivamente, con menor afectación. El mejor estado se halló en el bienestar espiritual, con promedio de 22,6. Conclusiones: la experiencia de ser cuidador modifica de manera importante la calidad de vida de las personas; los cuidadores, como fuente importante de cuidado informal, requieren apoyo de los sistemas de salud y, como parte de este, de los profesionales de enfermería.

  20. Accidental blood exposures among medical residents in Paris, France.

    Science.gov (United States)

    Mir, O; Adam, J; Veyrie, N; Chousterman, B; Gaillard, R; Gregory, T; Yordanov, Y; Berveiller, P; Loulergue, P

    2011-03-01

    Accidental blood exposure (ABE) exposes healthcare workers, including medical residents, to the risk of occupational infection. We aimed to determine the characteristics of ABEs in residents with an anonymous self-reporting electronic questionnaire. A total of 350 residents (33% from surgical disciplines) entered this survey. One hundred and eighty-five residents (52%) reported at least one ABE during their residency (median, 2; range, 1-25), 53% of which occurred in operating theatres. Sixty-nine per cent of residents followed the current procedures for local disinfection. ABEs were notified to the hospital administration by 62% of residents, but only 51% of residents were referred to the occupational medicine department. The most frequently reported concerns following ABEs were human immunodeficiency virus (52%) and hepatitis C virus infection (39%). In 74% of cases, the serological status of the index patient was investigated. Only 54% of residents were aware of their hepatitis B surface antibody titres. Medical residents behaved inappropriately in 33% of cases in this survey. Further educational programmes should include residents, and not only senior healthcare workers, in order to improve individual behaviours.

  1. Accidental intoxication with hydrochloric acid and hydrofluoric acid mixture

    Directory of Open Access Journals (Sweden)

    Anna Smędra-Kaźmirska

    2014-08-01

    Full Text Available The paper describes a fatal case of accidental ingestion of a mixture of hydrochloric acid and hydrofluoric acid. The man was admitted to hospital, where appropriate treatment, adequate to his condition, was instituted. Numerous ventricular fibrillation episodes, for which the patient was defibrillated repeatedly, were observed during the period of hospitalization. The patient was in a critical condition, with progressive symptoms of hypovolemic shock and multiorgan failure. On the next day after admission, signs of electromechanical dissociation progressing to asystole were noted. The instituted resuscitation procedure proved ineffective and the patient died. Autopsy revealed brownish discoloration of the esophageal, gastric, and small intestinal mucous membranes. Numerous ulcerations without signs of perforation were found both in the esophagus and in the stomach. The mucous membrane of the small intestine demonstrated focal rubefactions, whereas no focal lesions of the large intestinal mucosa were seen. Microscopic investigation of the biopsy specimens collected from the stomach, duodenum and small intestine revealed mucous membrane necrosis foci, reaching the deeper layers of the wall of these organs. The mucous membrane of the large intestine was congested. Bioptates obtained from the lungs indicated the presence of hemorrhagic infarcts and focal extravasations. Poisoning with the aforementioned acids with consequent necrosis of the esophageal, gastric, duodenal and small intestinal walls with hemorrhages to the gastrointestinal tract, as well as extravasations and hemorrhagic infarcts in the lungs was considered to be the cause of death.

  2. Accidental intoxication with hydrochloric acid and hydrofluoric acid mixture.

    Science.gov (United States)

    Smędra-Kaźmirska, A; Kędzierski, M; Barzdo, M; Jurczyk, Ap; Szram, S; Berent, J

    2014-01-01

    The paper describes a fatal case of accidental ingestion of a mixture of hydrochloric acid and hydrofluoric acid. The man was admitted to hospital, where appropriate treatment, adequate to his condition, was instituted. Numerous ventricular fibrillation episodes, for which the patient was defibrillated repeatedly, were observed during the period of hospitalization. The patient was in a critical condition, with progressive symptoms of hypovolemic shock and multiorgan failure. On the next day after admission, signs of electromechanical dissociation progressing to asystole were noted. The instituted resuscitation procedure proved ineffective and the patient died. Autopsy revealed brownish discoloration of the esophageal, gastric, and small intestinal mucous membranes. Numerous ulcerations without signs of perforation were found both in the esophagus and in the stomach. The mucous membrane of the small intestine demonstrated focal rubefactions, whereas no focal lesions of the large intestinal mucosa were seen. Microscopic investigation of the biopsy specimens collected from the stomach, duodenum and small intestine revealed mucous membrane necrosis foci, reaching the deeper layers of the wall of these organs. The mucous membrane of the large intestine was congested. Bioptates obtained from the lungs indicated the presence of hemorrhagic infarcts and focal extravasations. Poisoning with the aforementioned acids with consequent necrosis of the esophageal, gastric, duodenal and small intestinal walls with hemorrhages to the gastrointestinal tract, as well as extravasations and hemorrhagic infarcts in the lungs was considered to be the cause of death.

  3. Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose

    Directory of Open Access Journals (Sweden)

    Maria Ballesta Méndez

    2014-01-01

    Full Text Available Background. 4-Aminopyridine (4-AP is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS. Medication error can occur, as commercial preparation may not be available in some countries. Case Presentation. A 58-year-old woman with progressive MS presented with status epilepticus. She was receiving 4-AP for more than 3 years. The symptoms started soon after the ingestion of a single pill that was supposed to contain 10 mg 4-AP, but further investigations revealed that each pill had been inadvertently prepared with an 100 mg 4-AP concentration. The patient was admitted to the intensive care unit (ICU for appropriate management (orotracheal intubation, sedation, and antiepileptic drugs. The first electroencephalogram (EEG showed abundant irregular spike-waves on the left central regions. Neurological condition gradually improved from day 7, while the EEG did not reveal any more electrical seizures but was still consistent with toxic encephalopathy. The patient stayed in the ICU until day 13. At discharge from the rehabilitation ward (2.5 months later, the patient had not yet recovered her previous cognitive and functional condition. Conclusion. A single 100 mg 4-AP accidental overdose may cause serious immediate complications, with a slow and incomplete neurological recovery.

  4. ¿Accidente industrial o amputación deliberada?

    Directory of Open Access Journals (Sweden)

    Ponce, Paola

    2005-01-01

    Full Text Available El objetivo de este trabajo es analizar los diferentes aspectos de la práctica de amputaciones durante el período victoriano de Inglaterra tales como: las causas que llevaron a tal práctica, los métodos y técnicas quirúrgicos usados durante el S. XIX así como la evidencia de atrofia y/o asimetría por causa del desuso. Tres casos de amputaciones fueron encontrados en una población industrial en el cementerio Victoriano de St. Pete s Collegiate Church en Wolverhampton (West Midlands, Inglaterra. Las amputaciones fueron realizadas en el miembro superior de una mujer (HB53 y los miembros inferiores de dos hombres (HB86 y (HB129. Se concluye que en los tres casos los individuos sobrevivieron a las amputaciones y que estas fueron realizadas mucho tiempo antes de la muerte. Dos de ellas fueron probablemente realizadas mediante cirugía (HB86 y HB129 mientras que la tercera (HB53 podría ser el resultado de un accidente industrial.

  5. [Gonococcal vulvovaginitis in prepubertal girls: sexual abuse or accidental transmission?].

    Science.gov (United States)

    Daval-Cote, M; Liberas, S; Tristan, A; Vandenesch, F; Gillet, Y

    2013-01-01

    Vulvovaginitis is the most frequent gynecologic pathology among prepubertal females. An infectious cause is found in 30% of cases and is highly associated with the presence of vaginal discharge upon examination. Neisseria gonorrhoeae may be one of the causative agents. Since N. gonorrhoeae is a common sexually transmitted disease, sexual abuse should be considered in the pediatric setting. We report the case of a 5-year-old girl with N. gonorrhoeae vulvovaginitis. Her previous history, multiple interviews with the patient and her parents, and clinical examination showed no evidence or signs of sexual abuse. Both parents presented gonorrhea, urethritis for the father and vaginitis for the mother. The discrepancy between pediatric evaluation and the presence of a bacterium associated with sexually transmitted disease led us to consider other means of contamination. Previous studies have shown that other routes of transmission are possible but are often neglected. Hence, contamination can be transmitted by the hands or mostly through passive means (towels, rectal thermometer, etc.). Many epidemics have been noted in group settings with young girls with no evidence of sexual transmission. Therefore, we concluded that this patient's infection was likely an accidental transmission within her family. The acknowledgement of these transmission routes is very important in order to avoid misguided suspicion of sexual abuse and the possible traumatic family and psychosocial consequences.

  6. Accidental macular hole following Neodymium:YAG posterior capsulotomy

    Directory of Open Access Journals (Sweden)

    Munteanu Mihnea

    2014-01-01

    Full Text Available Introduction. Posterior capsular opacification (PCO is the commonest complication of cataract surgery, occurring in up to one-third of patients in a period of five years. The treatment of choice is the Neodymium:YAG laser posterior capsulotomy. This treatment can be associated with several complications, some of them severe. A rare complication of this procedure is the accidental induced macular hole. Case Outline. A 54-year-old female patient was referred to our Department because of a severe loss of vision and a central scotoma at the right eye. The patient underwent a Nd:YAG posterior capsulotomy 2 days ago, for a PCO. The fundus examination at presentation revealed a round retinal defect in the macular region, a massive inferior preretinal hemorrhage and a mild vitreous hamorrhage. A 6-months follow-up of the case, including retinography and fluorescein angiography, is presented. Conclusion. Although the Nd:YAG laser capsulotomy is a safe, noninvasive, and effective outpatient procedure to improve vision hindered by PCO, it must be recognized that it carries a low but definite risk of serious complications. Physicians and patients should be aware of these rare but severe complications regarding this otherwise safe procedure. Fortunately, most of the complications related to this procedure are transient and can be managed by proper medication.

  7. High mortality due to accidental salinomycin intoxication in sheep

    Directory of Open Access Journals (Sweden)

    Ashrafihelan Javad

    2014-09-01

    Full Text Available In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Laboratories, Iran had been added to the ration (22388 mg/kg = 22388 ppm and overnight was fed to herd. At the morning, 78 sheep were founded dead and one of them showed convulsive seizures. Postmortem examination revealed pulmonary congestion and edema, hemorrhages in abomasum, large pale kidney and white streak lines in myocardium. Main histopathologic lesions were extensive subepicardial and intercardiomyofibers hemorrhages, extensive cardiomyolysis and myocarditis in heart, severe hyperemia and extensive acute tubular necrosis (ATN in kidneys and focal necrosis and retention of bile cholangitis in the liver. In this study, on the basis of the history, observation of the ionophore remnant in the ration, clinical signs, gross and histopathological findings, acute salinomycin intoxication is definitely diagnosed.

  8. Accidental Cutaneous Burns Secondary to Salbutamol Metered Dose Inhaler

    Directory of Open Access Journals (Sweden)

    Ashutosh Kale

    2010-01-01

    Full Text Available We report a case of accidental cutaneous burns caused by salbutamol metered dose inhaler. A 9-year-old boy underwent dental extraction at a children's hospital and was incidentally noted to have burn injuries on dorsum of both hands. On questioning, the boy revealed that a few days ago his 14-year-old brother, who is an asthmatic, playfully sprayed his salbutamol metered dose inhaler on the back of both his hands with the inhaler's mouth piece being in direct contact with the patient's skin. On examination, there was a rectangular area of erythema with superficial peeling on the dorsum of both hands, the dimensions of which exactly matched those of the inhaler's mouthpiece. It is possible that the injury could have been a chemical burn from the pharmaceutical/preservative/propellant aerosol or due to the physical effect of severe cooling of the skin or mechanical abrasive effect of the aerosol blasts or a combination of some or all the above mechanisms. This case highlights the importance of informing children and parents of the potentially hazardous consequences of misusing a metered dose inhaler.

  9. Non-Accidental Health Impacts of Wildfire Smoke

    Science.gov (United States)

    Youssouf, Hassani; Liousse, Catherine; Roblou, Laurent; Assamoi, Eric-Michel; Salonen, Raimo O.; Maesano, Cara; Banerjee, Soutrik; Annesi-Maesano, Isabella

    2014-01-01

    Wildfires take a heavy toll on human health worldwide. Climate change may increase the risk of wildfire frequency. Therefore, in view of adapted preventive actions, there is an urgent need to further understand the health effects and public awareness of wildfires. We conducted a systematic review of non-accidental health impacts of wildfire and incorporated lessons learned from recent experiences. Based on the literature, various studies have established the relationship between one of the major components of wildfire, particulate matter (particles with diameter less than 10 µm (PM10) and less than 2.5 µm (PM2.5)) and cardiorespiratory symptoms in terms of Emergency Rooms visits and hospital admissions. Associations between wildfire emissions and various subclinical effects have also been established. However, few relationships between wildfire emissions and mortality have been observed. Certain segments of the population may be particularly vulnerable to smoke-related health risks. Among them, people with pre-existing cardiopulmonary conditions, the elderly, smokers and, for professional reasons, firefighters. Potential action mechanisms have been highlighted. Overall, more research is needed to better understand health impact of wildfire exposure. PMID:25405597

  10. Relative contributions of spatial weighting, explicit knowledge and proprioception to hand localisation during positional ambiguity.

    Science.gov (United States)

    Bellan, Valeria; Gilpin, Helen R; Stanton, Tasha R; Dagsdóttir, Lilja K; Gallace, Alberto; Lorimer Moseley, G

    2017-02-01

    When vision and proprioception are rendered incongruent during a hand localisation task, vision is initially weighted more than proprioception in determining location, and proprioception gains more weighting over time. However, it is not known whether, under these incongruency conditions, particular areas of space are also weighted more heavily than others, nor whether explicit knowledge of the sensory incongruence (i.e. disconfirming the perceived location of the hand) modulates the effect. Here, we hypothesised that both non-informative inputs coming from one side of space and explicit knowledge of sensory incongruence would modulate perceived location of the limb. Specifically, we expected spatial weighting to shift hand localisation towards the weighted area of space, and we expected greater weighting of proprioceptive input once perceived location was demonstrated to be inaccurate. We manipulated spatial weighting using an established auditory cueing paradigm (Experiment 1, n = 18) and sensory incongruence using the 'disappearing hand trick' (Experiment 2, n = 9). Our first hypothesis was not supported-spatial weighting did not modulate hand localisation. Our second hypothesis was only partially supported-disconfirmation of hand position did lead to more accurate localisations, even if participants were still unaware of their hand position. This raised the possibility that rather than disconfirmation, a simple movement of the hand in view could update the sensory-motor system, by immediately increasing the weighting of proprioceptive input relative to visual input. This third hypothesis was then confirmed (Experiment 3, n = 9). These results suggest that hand localisation is robust in the face of differential weighting of space, but open to modulation in a modality-specific manner, when one sense (vision) is rendered inaccurate.

  11. Parental response to child injury: examination of parental posttraumatic stress symptom trajectories following child accidental injury

    National Research Council Canada - National Science Library

    Le Brocque, Robyne M; Hendrikz, Joan; Kenardy, Justin A

    2010-01-01

    Trajectory analyses were used to empirically differentiate patterns of posttraumatic stress symptoms in parents following child accidental injury and explore the relationship between parent and child recovery patterns. Parent (n = 189...

  12. Romance, recognition and revenge in Marie Clements's The Unnatural and Accidental Women

    National Research Council Canada - National Science Library

    Bamford, Karen

    2010-01-01

    This essay considers the relationship of Marie Clements's The Unnatural and Accidental Women to European traditions of drama and folk narrative, and especially its relation to the genres of revenge tragedy and romance...

  13. Inhaled surfactant in the treatment of accidental talc powder inhalation: a new case report

    National Research Council Canada - National Science Library

    Matina, Federico; Collura, Mirella; Maggio, Maria Cristina; Vitulo, Patrizio; Lo Piparo, Caterina; Corsello, Giovanni

    2011-01-01

    .... Although the use of baby powder has been discouraged from many authors and the reports of its accidental inhalation have been ever more rare, sometimes new cases with several fatalities have been reported...

  14. NSAIDs and the risk of accidental falls in the elderly: a systematic review.

    NARCIS (Netherlands)

    Hegeman, J.; Bemt, B.J.F. van den; Duysens, J.E.J.; Limbeek, J. van

    2009-01-01

    Accidental falls, especially those occurring in the elderly, are a major health and research topic nowadays. Besides environmental hazards and the physiological changes associated with aging, medication use (e.g. benzodiazepines, vasodilators and antidepressants) and polypharmacy are significant

  15. Insertion of an intrathecal catheter following accidental dural puncture : a meta-analysis

    NARCIS (Netherlands)

    Heesen, M.; Kloehr, S.; Rossaint, R.; Walters, M.; Straube, S.; van de Velde, M.

    Background: Inserting an intrathecal catheter after accidental dural puncture in parturients to prevent postdural puncture headache is becoming increasingly popular. We aimed to identify relevant published articles investigating this intervention and subject data to a meta-analysis. Methods: A

  16. Management options for accidental injection of epinephrine from an autoinjector: a case report

    Directory of Open Access Journals (Sweden)

    Mathez Christian

    2009-06-01

    Full Text Available Abstract Introduction Epinephrine autoinjector devices are used with increasing frequency to treat severe anaphylactic reactions. Accidental injection, usually involving a finger, is a potential complication. Case presentation A physician in a Family Practice training program accidentally injected epinephrine into his left thumb while reading the operating instructions of an autoinjector (Epipen®. He developed swelling, pallor, and pain in the thumb. Treatment included topical nitroglycerin, oral vasodilators and warming of the thumb. As expected, none caused an immediate response; however, after 8 hours, the thumb was pink and warm. There was full recovery 2 months after the accident. We reviewed the treatment of accidental epinephrine injection, and found that the use of parenteral adrenergic alpha blocker phentolamine would have produced immediate recovery. Conclusions All health professionals concerned with the use of epinephrine autoinjectors should receive adequate instruction on their use. A regimen for management of accidental epinephrine injection, in particular the use of phentolamine, should be emphasized.

  17. Inhaled Surfactant in the treatment of accidental Talc Powder inhalation: a new case report

    OpenAIRE

    Lo Piparo Caterina; Vitulo Patrizio; Maggio Maria; Collura Mirella; Matina Federico; Corsello Giovanni

    2011-01-01

    Abstract The use of talcum powder is incorrectly part of the traditional care of infants. Its acute aspiration is a very dangerous condition in childhood. Although the use of baby powder has been discouraged from many authors and the reports of its accidental inhalation have been ever more rare, sometimes new cases with several fatalities have been reported. We report on a patient in which accidental inhalation of baby powder induced severe respiratory difficulties. We also point out the bene...

  18. Simple battery armor to protect against gastrointestinal injury from accidental ingestion

    OpenAIRE

    Laulicht, Bryan; Traverso, Giovanni; Deshpande, Vikram; Langer, Robert; Karp, Jeffrey M.

    2014-01-01

    Accidental battery ingestion in children is a recognized source of significant morbidity and mortality. To mitigate the risks of accidental battery ingestion, legislation has been introduced to regulate the locking of battery compartments. Regulation of battery housings has translated into modest reductions in the number of battery ingestion cases reported. We report here the fabrication of waterproof, pressure-sensitive battery coatings that are nonconductive in the low-pressure gastrointest...

  19. Subcellular localisation of Medicago truncatula 9/13-hydroperoxide lyase reveals a new localisation pattern and activation mechanism for CYP74C enzymes

    Directory of Open Access Journals (Sweden)

    Hughes Richard K

    2007-11-01

    Full Text Available Abstract Background Hydroperoxide lyase (HPL is a key enzyme in plant oxylipin metabolism that catalyses the cleavage of polyunsaturated fatty acid hydroperoxides produced by the action of lipoxygenase (LOX to volatile aldehydes and oxo acids. The synthesis of these volatile aldehydes is rapidly induced in plant tissues upon mechanical wounding and insect or pathogen attack. Together with their direct defence role towards different pathogens, these compounds are believed to play an important role in signalling within and between plants, and in the molecular cross-talk between plants and other organisms surrounding them. We have recently described the targeting of a seed 9-HPL to microsomes and putative lipid bodies and were interested to compare the localisation patterns of both a 13-HPL and a 9/13-HPL from Medicago truncatula, which were known to be expressed in leaves and roots, respectively. Results To study the subcellular localisation of plant 9/13-HPLs, a set of YFP-tagged chimeric constructs were prepared using two M. truncatula HPL cDNAs and the localisation of the corresponding chimeras were verified by confocal microscopy in tobacco protoplasts and leaves. Results reported here indicated a distribution of M.truncatula 9/13-HPL (HPLF between cytosol and lipid droplets (LD whereas, as expected, M.truncatula 13-HPL (HPLE was targeted to plastids. Notably, such endocellular localisation has not yet been reported previously for any 9/13-HPL. To verify a possible physiological significance of such association, purified recombinant HPLF was used in activation experiments with purified seed lipid bodies. Our results showed that lipid bodies can fully activate HPLF. Conclusion We provide evidence for the first CYP74C enzyme, to be targeted to cytosol and LD. We also showed by sedimentation and kinetic analyses that the association with LD or lipid bodies can result in the protein conformational changes required for full activation of the enzyme

  20. Persistent Seroconversion after Accidental Eye Exposure to Calcifying Nanoparticles

    Science.gov (United States)

    Ciftcioglu, Neva; Aho, Katja M.; McKay, David S.; Kajander, E. Olavi

    2007-01-01

    Biosafety of nanomaterials has attracted much attention recently. We report here a case where accidental human eye exposure to biogenic nanosized calcium phosphate in the form of calcifying nanoparticles (CNP) raised a strong IgG immune response against proteins carried by CNP. The antibody titer has persisted over ten years at the high level. The IgG was detected by ELISA using CNPs propagated in media containing bovine and human serum as antigen. The exposure incident occurred to a woman scientist (WS) at a research laboratory in Finland at 1993. CNP, also termed "nanobacteria", is a unique self-replicating agent that has not been fully characterized and no data on biohazards were available at that time. Before the accident, her serum samples were negative for both CNP antigen and anti-CNP antibody using specific ELISA tests (Nanobac Oy, Kuopio, Finland). The accident occurred while WS was harvesting CNP cultures. Due to a high pressure in pipetting, CNP pellet splashed into her right eye. Both eyes were immediately washed with water and saline. The following days there was irritation and redness in the right eye. These symptoms disappeared within two weeks without any treatment. Three months after the accident, blood and urine samples of WS were tested for CNP cultures (2), CNP-specific ELISA tests, and blood cell counts. Blood cell counts were normal, CNP antigen and culture tests were negative. A high IgG anti-CNP antibody titer was detected (see Figure). The antibodies of this person have been used thereafter as positive control and standard in ELISA manufacturing (Nano-Sero IgG ELISA, Nanobac Oy, Kuopio, Finland).

  1. Public agencies in Serbia accidental error or bad intention

    Directory of Open Access Journals (Sweden)

    Milkov Dragan

    2014-01-01

    Full Text Available English term 'agency' has appeared in the Serbian legal system after the political changes in 2000. At first, the Law on Ministries in 2004 created bodies of state administration under the name of the agency and administrative organizations and in 2005 has been passed the Law on Public Agencies, which provides agencies as autonomous entities that are not directly part of the state administration. In addition, in the last ten years in Serbia was created a whole range of subjects of different legal status under the name of the agency. It should be borne in mind that the organization and structure of public administration in Serbia are mostly based on the Germanic tradition and that Serbia has long used the German term for persons performing administrative activities: 'Verwaltungsorgan'. Without any objective need, in addition to traditional forms of bodies performing administrative activities in Serbia has been created a new form called the agency. This has only brought the confusion into by then relatively harmonized system of governance structures, where the name of the former administration and some other subjects changed to agencies and some new, who previously did not exist, have been also created. This has led to the growth of covert administration. Agency name is not unknown in the world and in the US is used since the 18th century. However, instead of the name in English is translated into Serbian language in an adapted way, as it corresponds to the traditional Serbian terminology, this accidental error later turned into a bad intention of creating an ever-larger number of entities called agency.

  2. The nature of carrier localisation in polar and nonpolar InGaN/GaN quantum wells

    Science.gov (United States)

    Dawson, P.; Schulz, S.; Oliver, R. A.; Kappers, M. J.; Humphreys, C. J.

    2016-05-01

    In this paper, we compare and contrast the experimental data and the theoretical predictions of the low temperature optical properties of polar and nonpolar InGaN/GaN quantum well structures. In both types of structure, the optical properties at low temperatures are governed by the effects of carrier localisation. In polar structures, the effect of the in-built electric field leads to electrons being mainly localised at well width fluctuations, whereas holes are localised at regions within the quantum wells, where the random In distribution leads to local minima in potential energy. This leads to a system of independently localised electrons and holes. In nonpolar quantum wells, the nature of the hole localisation is essentially the same as the polar case but the electrons are now coulombically bound to the holes forming localised excitons. These localisation mechanisms are compatible with the large photoluminescence linewidths of the polar and nonpolar quantum wells as well as the different time scales and form of the radiative recombination decay curves.

  3. Photoletter to the editor: Dermatitis herpetiformis co-localised with vitiligo in a patient with autoimmune polyglandular syndrome.

    Science.gov (United States)

    Macbeth, Abby E; Lee, Kevin Y C; Levell, Nick J; Igali, Laszlo; Millington, George W M

    2013-01-01

    We report a case of dermatitis herpetiformis co-localised with segmental vitiligo in a 37-year-old woman with a background history of autoimmune polyglandular syndrome type 2. We propose genetic mosaicism as a possible mechanism. There has only been one previous case report in which dermatitis hepetiformis co-localised in close proximity but not exclusively within vilitigo in a patient with autoimmune thyroiditis. To our knowledge, this is the first case report of dermatitis herpetiformis co-localised exclusively to segmental vitiligo in the presence of autoimmune polyglandular syndrome.

  4. Flow in a circular expansion pipe flow: effect of a vortex perturbation on localised turbulence

    Science.gov (United States)

    Selvam, Kamal; Peixinho, Jorge; Willis, Ashley P.

    2016-12-01

    We report the results of three-dimensional direct numerical simulations for incompressible viscous fluid in a circular pipe flow with a sudden expansion. At the inlet, a parabolic velocity profile is applied together with a finite amplitude perturbation in the form of a vortex with its axis parallel to the axis of the pipe. At sufficiently high Reynolds numbers the recirculation region breaks into a turbulent patch that changes position axially, depending on the strength of the perturbation. This vortex perturbation is believed to produce a less abrupt transition than in previous studies, which applied a tilt perturbation, as the localised turbulence is observed via the formation of a wavy structure at a low order azimuthal mode, which resembles an optimally amplified perturbation. For large vortex amplitude, the localised turbulence remains at a constant axial position. It is further investigated using proper orthogonal decomposition, which indicates that the centre region close to the expansion is highly energetic.

  5. Aesthetic Proximity: the Role of Stylistic Programme Elements in Format Localisation

    Directory of Open Access Journals (Sweden)

    Jolien van Keulen

    2016-08-01

    Full Text Available Implications of the transnationalisation of television are often studied by focusing on the localisation of the content of formatted programmes. Although television is essentially an audio-visual medium, little attention has been paid to the aesthetic aspects of television texts in relation to transnationalisation and formatting. Transnationalisation of production practices, such as through formatting, implies a transnational aesthetic. At the same time, aspects of style are specific to place, culture or audience. In this article, the localisation of stylistic programme elements is explored using a comparison of two reality format adaptations. It is argued that style plays an important role in the expression of the local in a transnational industry.

  6. Une localisation exceptionnelle de la tuberculose vertébrale Mal de Pott sous-occipital

    Science.gov (United States)

    Yahyaoui, Sana; Majdoub, Senda; Zaghouani, Houneida; Fradj, Hosni Ben; Bakir, Dejla; Bouajina, Elyes; Kraiem, Chakib

    2013-01-01

    Le mal de Pott est la forme la plus commune de la tuberculose osseuse touchant essentiellement le rachis dorso-lombaire. La localisation sous-occipitale reste exceptionnelle. Le diagnostic de cette entité est le plus souvent tardif ce qui expose à des complications graves. Les radiographies standard ne sont parlantes qu’à un stade tardif de la maladie, d'où l'intérêt de l'imagerie moderne notamment la tomodensitométrie (TDM) et l'imagerie par résonance magnétique (IRM) qui permettent un diagnostic précoce. Nous rapportons un nouveau cas de tuberculose sous-occipitale. Le diagnostic était posé sur l'imagerie en coupe et confirmé histologiquement à la biopsie transorale. Sont rappelés les aspects en imagerie de cette localisation particulière du mal de Pott. PMID:23819005

  7. Bringing order through disorder: Localisation of errors in topological quantum memories

    CERN Document Server

    Wootton, James R

    2011-01-01

    The ability to reliably store quantum states is an essential element for any task in quantum information. Topological systems promise to protect quantum information by topological and energetic considerations. If undesired anyonic excitations are propagated at large distances, either through coherent or probabilistic processes, they can cause logical errors in the topologically encoded information. Here we show that Anderson localisation induced by disorder in the system can successfully protect topological quantum memories from the coherent propagation of anyons. For concreteness we employ the toric code model at zero temperature. It is known that in the absence of a magnetic field it can tolerate a finite initial density of anyonic errors. In the presence of a spurious magnetic field anyonic quantum walks are induced and the tolerable density becomes zero. We demonstrate that disorder in the couplings of the model can successfully localise anyons. This allows the topological quantum memory to tolerate a fin...

  8. Localisation of Information and Communication Technologies in Cameroonian Languages and Cultures:Experience and Issues

    Directory of Open Access Journals (Sweden)

    Mathurin Soh

    2015-12-01

    Full Text Available In this paper, we tackle the problem of adapting Information and Communication Technologies (ICTs in local languages of Cameroon. The objectives are to reduce the digital and language divides, and to pave the way for the usage of such technologies to local populations who don’t understand this technological language. We first discuss and highlight several concerns about the localisation of ICTs. Afterwords, we address some challenges and issues to computerize cultural and linguistic features, and indigenous knowledge (IK for national languages and cultures in Cameroon. As case study, we describe our experience in localising an open source editor for the Yemba language, within the of Rural Electronic Schools in African Languages Project. Because Cameroonian languages are based on the same basic alphabet, this qualitative research is extensible to other languages.

  9. Reprint of: Four-terminal resistances in mesoscopic networks of metallic wires: Weak localisation and correlations

    Science.gov (United States)

    Texier, Christophe; Montambaux, Gilles

    2016-08-01

    We consider the electronic transport in multi-terminal mesoscopic networks of weakly disordered metallic wires. After a brief description of the classical transport, we analyse the weak localisation (WL) correction to the four-terminal resistances, which involves an integration of the Cooperon over the wires with proper weights. We provide an interpretation of these weights in terms of classical transport properties. We illustrate the formalism on examples and show that weak localisation to four-terminal conductances may become large in some situations. In a second part, we study the correlations of four-terminal resistances and show that integration of Diffuson and Cooperon inside the network involves the same weights as the WL. The formulae are applied to multiconnected wire geometries.

  10. Four-terminal resistances in mesoscopic networks of metallic wires: Weak localisation and correlations

    Science.gov (United States)

    Texier, Christophe; Montambaux, Gilles

    2016-01-01

    We consider the electronic transport in multi-terminal mesoscopic networks of weakly disordered metallic wires. After a brief description of the classical transport, we analyse the weak localisation (WL) correction to the four-terminal resistances, which involves an integration of the Cooperon over the wires with proper weights. We provide an interpretation of these weights in terms of classical transport properties. We illustrate the formalism on examples and show that weak localisation to four-terminal conductances may become large in some situations. In a second part, we study the correlations of four-terminal resistances and show that integration of Diffuson and Cooperon inside the network involves the same weights as the WL. The formulae are applied to multiconnected wire geometries.

  11. Towards quantification of the interplay between strain weakening and strain localisation in granular material

    Science.gov (United States)

    Ritter, Malte C.; Rosenau, Matthias; Leever, Karen; Oncken, Onno

    2014-05-01

    Strain weakening is the major agent of localisation of deformation into shear zones and faults at various scales in brittle media. Physical analogue models using granular material are especially apt to investigate both phenomena, because they are able to reproduce them without the need of any assumptions concerning the physics behind. Several attempts have been made to quantify either strain weakening (e. g. Lohrmann et al., 2003, using Ring-Shear tests) or strain localisation (e. g. Schrank et al., 2008, using a variation of the classical Riedel-experiment). While Ring-Shear tests yield excellent data on strain weakening through measuring shear stress during localisation, they do not allow monitoring the process of strain localisation in-situ because of experimental inaccessibility of the small scale kinematics. In Riedel-type strike-slip experiments, on the other hand, no direct measurements of shear stresses have been available so far. Furthermore, they contain a strong boundary condition in form of a pre-defined linear discontinuity at the base. This forces the formation of Riedel-Shears, i. e. a complex fault system, that makes it difficult to define strain localisation on single faults. We developed a new experimental set-up, in which the formation of a strike-slip shear zone in granular material is induced using an ndenter with stress and strain monitored at high accuracy and resolution. In a first set of experiments we used a horizontal sand layer indented by a vertical wall. The sand layer is laterally unconfined and rests on low-viscosity silicone oil in order to minimize basal shear strength. Compared to the Riedel experiments, this avoids the boundary condition of a pre-existing basal discontinuity allowing one single, hrough-going shear crack to form and propagate. The indenter moves at a constant rate and is equipped with a force sensor that measures the applied push, which integrates over shear stresses along the fault and the base of the sand pack

  12. Photon counting imaging and centroiding with an electron-bombarded CCD using single molecule localisation software

    Science.gov (United States)

    Hirvonen, Liisa M.; Barber, Matthew J.; Suhling, Klaus

    2016-06-01

    Photon event centroiding in photon counting imaging and single-molecule localisation in super-resolution fluorescence microscopy share many traits. Although photon event centroiding has traditionally been performed with simple single-iteration algorithms, we recently reported that iterative fitting algorithms originally developed for single-molecule localisation fluorescence microscopy work very well when applied to centroiding photon events imaged with an MCP-intensified CMOS camera. Here, we have applied these algorithms for centroiding of photon events from an electron-bombarded CCD (EBCCD). We find that centroiding algorithms based on iterative fitting of the photon events yield excellent results and allow fitting of overlapping photon events, a feature not reported before and an important aspect to facilitate an increased count rate and shorter acquisition times.

  13. Three-dimensional sound localisation with a lizard peripheral auditory model

    DEFF Research Database (Denmark)

    Schmidt, Michael Kjær; Shaikh, Danish

    2017-01-01

    sensorimotor approach to three-dimensional sound source localisation employing two microphones, where directed movements of the microphones resolve the location of an acoustic target in three dimensions. The approach utilises a model of the peripheral auditory system of lizards coupled with a multi......-layer perceptron neural network. The peripheral auditory model provides sound direction information in a single plane which by itself is insufficient to localise the acoustic target in three dimensions. Two spatial orientations of this plane by rotating the microphones −45 degrees and +45 degrees along...... the sagittal axis generate two maps of sound direction. Weighted superposition of these two maps results in a map that encodes sound direction information in three dimensions. Two independent but neural networks with respectively one and two hidden layers are trained on these maps via supervised learning...

  14. Fluctuating exciton localisation in giant pi-conjugated spoked-wheel macrocycles

    CERN Document Server

    Aggarwal, Vikas; Idelson, Alissa; Kalle, Daniel; Wuersch, Dominik; Stang, Thomas; Steiner, Florian; Jester, Stefan-S; Vogelsang, Jan; Hoeger, Sigurd; Lupton, John M

    2015-01-01

    Conjugated polymers offer potential for many diverse applications but we still lack a fundamental microscopic understanding of their electronic structure. Elementary photoexcitations - excitons - span only a few nanometres of a molecule, which itself can extend over microns, and how their behaviour is affected by molecular dimensions is not fully understood. For example, where is the exciton formed within a conjugated segment, is it always situated on the same repeat units? Here, we introduce structurally-rigid molecular spoked wheels, 6 nanometres in diameter, as a model of extended pi-conjugation. Single-molecule fluorescence reveals random exciton localisation, leading to temporally-varying emission polarisation. Initially, this random localisation arises after every photon absorption event because of temperature independent spontaneous symmetry breaking. These fast fluctuations are slowed to millisecond timescales following prolonged illumination. Intramolecular heterogeneity is revealed in cryogenic spec...

  15. Complexity of localised coherent structures in a boundary-layer flow

    CERN Document Server

    Khapko, Taras; Kreilos, Tobias; Schlatter, Philipp; Eckhardt, Bruno; Henningson, Dan S

    2013-01-01

    We study numerically transitional coherent structures in a boundary-layer flow with homogeneous suction at the wall (the so-called asymptotic suction boundary layer ASBL). The dynamics restricted to the laminar-turbulent separatrix is investigated in a spanwisely extended domain that allows for robust localisation of all edge states. We work at fixed Reynolds number and study the edge states as a function of the streamwise period. We demonstrate the complex spatio-temporal dynamics of these localised states, which exhibits multistability and undergoes complex bifurcations leading from periodic to chaotic regimes. It is argued that in all regimes the dynamics restricted to the edge is essentially low-dimensional and non-extensive.

  16. Critical Behaviour in the Relaminarisation of Localised Turbulence in Pipe Flow

    CERN Document Server

    Willis, A P

    2006-01-01

    The statistics of the relaminarisation of localised turbulence in a pipe are examined by direct numerical simulation. As in recent experimental data (Peixinho & Mullin, Phys. Rev. Lett. 96, 094501, 2006), the half life for the decaying turbulence is consistent with the scaling (Re_c-Re)^{-1}, indicating a boundary crisis of the localised turbulent state familiar in low-dimensional dynamical systems. The crisis Reynolds number, is estimated as Re_c=1870, a value within 7% of the experimental value 1750. We argue that the frequently-asked question of which Re and initial disturbance are needed to trigger sustained turbulence in a pipe, is really two separate questions: the `local phase space' question (local to the laminar state) of what threshold disturbance at a given Re is needed to initially trigger turbulence, followed by the `global phase space' question of whether Re exceeds Re_c at which point the turbulent state becomes an attractor.

  17. Critical Factors in Transnational Oil Companies Localisation Decisions - Clusters and Portfolio Optimisation

    Energy Technology Data Exchange (ETDEWEB)

    Kind, Hans Jarle; Osmundsen, Petter; Tverteraas, Ragnar

    2001-10-01

    Enhanced understanding of the factors determining transnational companies' localisation decisions is important for regulators and other stakeholders concerned about maintaining current activity levels in a petroleum producing country. This article discusses localisation decisions in the context of theories of industrial clusters and real portfolio optimisation theory (materiality), which we argue are two fruitful lines of explanation for transnational companies' behaviour. The industrial cluster literature is concerned about the level of positive externalities associated with geographic clustering of related production activities. The concept of materiality, implying that investment projects in an oil province must be of a certain minimum size in order to be interesting for oil companies, is evaluated empirically and compared to predictions of mainstream economic theory. (author)

  18. Análisis de accidentes severos en contenciones nucleares

    Directory of Open Access Journals (Sweden)

    Goicolea Ruigómez, José María

    1992-04-01

    Full Text Available Analysis for severe accidents has recently been added to the long list of requisites imposed on nuclear power plants. In this work we study the rationale and justiflcation for this type of analysis. Calculations for the structural response of the containment buildings can be performed on the computer using advanced nonlinear Finite Element codes. A state of the art review of these methods is carried out, proposing a methodology based on analysis by numerical methods with experimental validation. Additionally we present some results obtained by the authors for the analysis of both reinforced concrete and steel containments. The concluding remarks show the validity of the proposed methodology, as well as the evidence of a large security margin in the containments, due mainly to the conservatisms in the design stage.

    El análisis frente a accidentes severos ha venido a añadirse recientemente a la larga lista de requisitos impuestos a las centrales nucleares. En este trabajo se pretende estudiar la problemática y justificación de este tipo de análisis. El cálculo de la respuesta de la contención se puede realizar en el ordenador mediante métodos avanzados de elementos finitos no lineales. Se hace una revisión del estado de la técnica en estos métodos, proponiendo una metodología basada en el análisis mediante modelos numéricos con validación experimental. Se presentan asimismo los resultados de análisis realizados, para contenciones tanto de hormigón armado como metálicas. Las conclusiones del trabajo establecen la validez de la metodología empleada, así como la constatación de un amplio margen de seguridad existente en las contenciones evaluadas, debido a los conservadurismos del proceso de diseño original.

  19. Accidentes de trabajo fatales y violencia interpersonal en Brasil, 2000-2010

    Directory of Open Access Journals (Sweden)

    Vilma Sousa Santana

    2013-01-01

    Full Text Available En el presente estudio se estima la mortalidad proporcional por accidentes de trabajo provocados por violencia interpersonal en Brasil, entre 2000 y 2010. Se analizaron los datos del Sistema de Información sobre Mortalidad, basados en los informes estadísti- cos de defunción del Ministerio de Salud de Brasil, los cuales incluyen un campo para el registro de accidentes de trabajo que debe ser completado en toda defunción por causas externas. Se identificaron 1.368.732 casos de defunciones por causas externas, 31.576 (2,3% por accidentes de trabajo y solo 226 (0,02% por accidentes de trabajo con violen- cia interpersonal. Cerca del 80% de los informes estadísticos de defunción no tenían el campo “accidente de trabajo” completado. La mayor cantidad de casos ocurrió entre hom- bres (94,3% de 25-34 años, con nivel de escolaridad medio, ubicados en la región sudeste y noreste, que trabajan principalmente en la producción de bienes y servicios industriales y la actividad agropecuaria. La mayoría de los casos fueron causados por armas de fuego, seguidos por armas blancas, con un aumento relativo de estos últimos en el período estu- diado. Los resultados sugieren un gran subregistro de diagnósticos que reconocen la rela- ción con el trabajo. Se hace necesaria una mejor capacitación en el llenado de los informes estadísticos, así como estudios que cuantifiquen el subregistro de accidentes de trabajo y accidentes de trabajo con violencia interpersonal.

  20. Rapid iterative method for electronic-structure eigenproblems using localised basis functions

    Science.gov (United States)

    Rayson, M. J.; Briddon, P. R.

    2008-01-01

    Eigenproblems resulting from the use of localised basis functions (typically Gaussian or Slater type orbitals) in density functional electronic-structure calculations are often solved using direct linear algebra. A full implementation is presented built around an iterative method known as 'residual minimisation—direct inversion of the iterative subspace' (RM-DIIS) to be used to solve many similar eigenproblems in a self-consistency cycle. The method is more efficient than direct methods and exhibits superior scaling on parallel supercomputers.

  1. LOCALISATIONS ET DYNAMIQUES DE DIFFUSION DES AGENCES DE TRAVAIL INTÉRIMAIRE EN FRANCE

    OpenAIRE

    Daudé, Eric

    2002-01-01

    International audience; Les choix de localisation des agences de travail intérimaire sont fonction de contraintes économiques spécifiques. Que ce soit du point de vue de l'offre ou de la demande de travail, ces agences doivent satisfaire un certain nombre d'exigences économiques dans le choix d'implantation pour rester efficaces sur un marché de plus en plus compétitif.

  2. Intra-operative tumour localisation in robot-assisted minimally invasive surgery:A review

    OpenAIRE

    Li, Min; Liu, Hongbin; Jiang, Allen; Seneviratne, Lakmal D.; Dasgupta, Prokar; Althoefer, Kaspar; Wurdemann, Helge

    2014-01-01

    Robot-assisted minimally invasive surgery has many advantages compared to conventional open surgery and also certain drawbacks: it causes less operative trauma and faster recovery times but does not allow for direct tumour palpation as is the case in open surgery. This article reviews state-of-the-art intra-operative tumour localisation methods used in robot-assisted minimally invasive surgery and in particular methods that employ force-based sensing, tactile-based sensing, and medical imagin...

  3. Immunocytochemical localisation of phospholipid hydroperoxide glutathione peroxidase in bull’s spermatogenic cells

    OpenAIRE

    Francesco Parillo; Lakamy Sylla; Claudio Palombi; Maurizio Monaci; Giuseppe Stradaioli

    2014-01-01

    Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a selenoprotein, which protects biomembranes from oxidative damages, and it also accounts for almost the entire selenium content of mammalian testis. The present investigation was performed to localise PHGPx in the testis and in epididymal and ejaculated spermatozoa of the bull by using light and electron immunomicroscopy. The study also aimed to further clarify the possible functions of the protein in bull fertility. In the testis,...

  4. Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity.

    Science.gov (United States)

    Wang, Xiaoyan; Moualla, Dima; Wright, Josephine A; Brown, David R

    2010-05-01

    Alpha-synuclein is a natively unfolded protein that aggregates and forms inclusions that are associated with a range of diseases that include Parkinson's Disease and Dementia with Lewy Bodies. The mechanism behind the formation of these inclusions and their possible role in disease remains unclear. Alpha-synuclein has also been shown to bind metals including copper and iron. We used a cell culture model of alpha-synuclein aggregation to examine the relationship between metals and formation of aggregates of the protein. While the levels of iron appear to have no role in aggregate formation or localisation of the protein in cells, copper appears to be important for both aggregation and cellular localisation of alpha-synuclein. Reduction in cellular copper resulted in a great decrease in aggregate formation both in terms of large aggregates visible in cells and oligomers observed in western blot analysis of cell extracts. Reduction in copper also resulted in a change in localisation of the protein which became more intensely localised to the plasma membrane in medium with low copper. These changes were reversed when copper was restored to the cells. Mutants of the copper binding domains altered the response to copper. Deletion of either the N- or C-termini resulted in a loss of aggregation while deletion of the C-termini also resulted in a loss of membrane association. Increased expression of alpha-synuclein also increased cell sensitivity to the toxicity of copper. These results suggest that the potential pathological role of alpha-synuclein aggregates is dependent upon the copper binding capacity of the protein.

  5. Ureteric angioplasty balloon placement to increase localised dosage of BCG for renal pelvis TCC.

    LENUS (Irish Health Repository)

    Forde, J C

    2012-03-01

    Endoscopic percutaneous resection of a renal pelvis transitional cell carcinoma (TCC) is a viable treatment option in those who would be rendered dialysis dependent following a nephroureterectomy. We report endoscopic percutaneous resection of an upper tract TCC recurrence in a single functioning kidney followed by antegrade renal pelvis BCG instillation with novel placement of inflated angioplasty balloon in the ureter to help localise its effect.

  6. An extended finite element model for modelling localised fracture of reinforced concrete beams in fire

    OpenAIRE

    Liao, F; Huang, Z.

    2015-01-01

    Open Access funded by Engineering and Physical Sciences Research Council under a Creative Commons license. A robust finite element procedure for modelling the localised fracture of reinforced concrete beams at elevated temperatures is developed. In this model a reinforced concrete beam is represented as an assembly of 4-node quadrilateral plain concrete, 3-node main reinforcing steel bar, and 2-node bond-link elements. The concrete element is subdivided into layers for considering the temp...

  7. On The Role of MHD Waves in Heating Localised Magnetic Structures

    Science.gov (United States)

    Erdélyi, R.; Nelson, C. J.

    2016-04-01

    Satellite and ground-based observations from e.g. SOHO, TRACE, STEREO, Hinode, SDO and IRIS to DST/ROSA, IBIS, CoMP, STT/CRISP have provided a wealth of evidence of waves and oscillations present in a wide range of spatial scales of the magnetised solar atmosphere. Our understanding about localised solar structures has been considerably changed in light of these high spatial and time resolution observations. However, MHD waves not only enable us to perform sub-resolution magneto-seismology of magnetic waveguides but are also potential candidates to carry and damp the necessary non-thermal energy in these localised waveguides. First, we will briefly outline the basic recent developments in MHD wave theory focussing on linear waves. Next, we discuss the role of the most frequently studied wave classes, including the Alfven, and magneto-acoustic kink and sausage waves. The current theoretical (and often difficult) interpretations of the detected solar atmospheric wave and oscillatory phenomena within the framework of MHD will be shown. Last, the latest reported observational findings of potential MHD wave flux, in terms of localised plasma heating, in the solar atmosphere is discussed, bringing us closer to solve the coronal heating problem.

  8. Evidence of phase nucleation during olivine diffusion creep: A new perspective for mantle strain localisation

    Science.gov (United States)

    Précigout, Jacques; Stünitz, Holger

    2016-12-01

    For the past decades, grain size reduction leading to diffusion creep in olivine is believed to be a very important process for strain localisation in the lithospheric mantle. However, the mechanisms of grain size reduction in this regime are still poorly understood (e.g., Platt, 2015). Here we show new experimental results that document grain size reduction and material weakening during wet olivine diffusion creep. While occurring for both, mono-phase and two-phase aggregates, grain size reduction is coeval with strain localisation and local phase mixing in olivine-pyroxene aggregates. Based on evidence of fluid inclusions and cracks filled with a fine-grained phase mixture, we conclude that grain size reduces as a result of fluid-assisted nucleation that takes place in the presence of an aqueous fluid during diffusion creep. Cavitation induced by grain boundary sliding (creep cavitation) can be inferred, and may play a critical role for olivine grain size reduction. Amongst their implications for rock rheology in general, our findings highlight a key process for strain localisation in the ductile uppermost mantle.

  9. Aquaporins 7 and 11 in boar spermatozoa: detection, localisation and relationship with sperm quality.

    Science.gov (United States)

    Prieto-Martínez, Noelia; Vilagran, Ingrid; Morató, Roser; Rodríguez-Gil, Joan E; Yeste, Marc; Bonet, Sergi

    2016-04-01

    Aquaporins (AQPs) are integral membrane water channels that allow transport of water and small solutes across cell membranes. Although water permeability is known to play a critical role in mammalian cells, including spermatozoa, little is known about their localisation in boar spermatozoa. Two aquaporins, AQP7 and AQP11, in boar spermatozoa were identified by western blotting and localised through immunocytochemistry analyses. Western blot results showed that boar spermatozoa expressed AQP7 (25kDa) and AQP11 (50kDa). Immunocytochemistry analyses demonstrated that AQP7 was localised in the connecting piece of boar spermatozoa, while AQP11 was found in the head and mid-piece and diffuse labelling was also seen along the tail. Despite differences in AQP7 and AQP11 content between boar ejaculates, these differences were not found to be correlated with sperm quality in the case of AQP7. Conversely, AQP11 content showed a significant correlation (Psperm membrane integrity and fluidity and sperm motility. In conclusion, boar spermatozoa express AQP7 and AQP11, and the amounts of AQP11 but not those of AQP7 are correlated with sperm motility and membrane integrity.

  10. Illumination-invariant image matching for autonomous UAV localisation based on optical sensing

    Science.gov (United States)

    Wan, Xue; Liu, Jianguo; Yan, Hongshi; Morgan, Gareth L. K.

    2016-09-01

    This paper presents an UAV (Unmanned Aerial Vehicle) localisation algorithm for its autonomous navigation based on matching between on-board UAV image sequences to a pre-installed reference satellite image. As the UAV images and the reference image are not necessarily taken under the same illumination condition, illumination-invariant image matching is essential. Based on the investigation of illumination-invariant property of Phase Correlation (PC) via mathematical derivation and experiments, we propose a PC based fast and robust illumination-invariant localisation algorithm for UAV navigation. The algorithm accurately determines the current UAV position as well as the next UAV position even the illumination condition of UAV on-board images is different from the reference satellite image. A Dirac delta function based registration quality assessment together with a risk alarming criterion is introduced to enable the UAV to perform self-correction in case the UAV deviates from the planned route. UAV navigation experiments using simulated terrain shading images and remote sensing images have demonstrated a robust high performance of the proposed PC based localisation algorithm under very different illumination conditions resulted from solar motion. The superiority of the algorithm, in comparison with two other widely used image matching algorithms, MI (Mutual Information) and NCC (Normalised Correlation Coefficient), is significant for its high matching accuracy and fast processing speed.

  11. On the Localisation of 4-Dimensional Brane-World Black Holes

    CERN Document Server

    Kanti, P; Zuleta, K

    2013-01-01

    In the context of brane-world models, we pursue the question of the existence of 5-dimensional solutions describing regular black holes localised close to the brane. Employing a perturbed Vaidya-type line-element embedded in a warped fifth dimension, we attempt to localise the extended black-string singularity, and to restore the regularity of the AdS spacetime at a finite distance from the brane by introducing an appropriate bulk energy-momentum tensor. As a source for this bulk matter, we are considering a variety of non-ordinary field-theory models of scalar fields either minimally-coupled to gravity, but including non-canonical kinetic terms, mixing terms, derivative interactions and ghosts, or non-minimally-coupled to gravity through a general coupling to the Ricci scalar. In all models considered, even in the ones characterised by a high-degree of flexibility, a negative result was reached. Our analysis demonstrates how difficult the analytic construction of a localised brane-world black hole may be in ...

  12. Multifocal pattern electroretinogram does not demonstrate localised field defects in glaucoma.

    Science.gov (United States)

    Klistorner, A I; Graham, S L; Martins, A

    2000-01-01

    To determine if a multifocal PERG could be recorded in normals, and to examine changes in the multifocal PERG in glaucoma patients. To compare the ability of multifocal PERG and multifocal VEP responses in the same individuals to identify localised field defects in glaucoma. Using the VERIS Scientific system multifocal PERGs were recorded from 19 sites of the visual field according to pseudo-random binary m-sequence. Twenty normals and 15 glaucoma subjects were tested. Multifocal pattern VEPs were also recorded in the glaucoma cases using a cortically scaled stimulus. The second order kernel of the PERG shows a consistent signal. The overall PERG amplitude decreases with age in normals. In glaucoma the PERG amplitude was reduced across the field, but reductions did not correspond to the area of the scotoma. The VEP showed localised signal reductions in all 15 cases of glaucoma. A multifocal PERG can be recorded in normals. However it did not reflect localised ganglion cell losses, whereas the multifocal pattern VEP recorded to a very similar stimulus in the same individual did show losses in the scotoma area.

  13. Immunocytochemical localisation of phospholipid hydroperoxide glutathione peroxidase in bull’s spermatogenic cells

    Directory of Open Access Journals (Sweden)

    Francesco Parillo

    2014-09-01

    Full Text Available Phospholipid hydroperoxide glutathione peroxidase (PHGPx is a selenoprotein, which protects biomembranes from oxidative damages, and it also accounts for almost the entire selenium content of mammalian testis. The present investigation was performed to localise PHGPx in the testis and in epididymal and ejaculated spermatozoa of the bull by using light and electron immunomicroscopy. The study also aimed to further clarify the possible functions of the protein in bull fertility. In the testis, spermatogenic cells of the adluminal tubular compartment showed cytoplasmatic immunostaining; whereas, in the epididymal and ejaculated spermatozoa immunostaining was specifically localised at the level of the head and mid-piece. Ultrastructural data revealed the presence of signals for PHGPx in different subcellular compartments of maturing and mature sperm (mitochondria, chromatin, nuclear envelope, acrosomes, cytoskeletal structures suggesting that this enzyme plays versatile and important biological roles during spermatogenesis. The final localisation of the immunostaining at acrosomal level puts forward a new role of the protein which further emphasises its relevance in male reproduction: it is reported to anchor substrate of the sperm acrosome to the oocyte zona pellucida during the fertilisation process.

  14. TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.

    Science.gov (United States)

    Baker, Karen; Kirkham, Sara; Halova, Lenka; Atkin, Jane; Franz-Wachtel, Mirita; Cobley, David; Krug, Karsten; Maček, Boris; Mulvihill, Daniel P; Petersen, Janni

    2016-07-01

    The timing of cell division is controlled by the coupled regulation of growth and division. The target of rapamycin (TOR) signalling network synchronises these processes with the environmental setting. Here, we describe a novel interaction of the fission yeast TOR complex 2 (TORC2) with the cytokinetic actomyosin ring (CAR), and a novel role for TORC2 in regulating the timing and fidelity of cytokinesis. Disruption of TORC2 or its localisation results in defects in CAR morphology and constriction. We provide evidence that the myosin II protein Myp2 and the myosin V protein Myo51 play roles in recruiting TORC2 to the CAR. We show that Myp2 and TORC2 are co-dependent upon each other for their normal localisation to the cytokinetic machinery. We go on to show that TORC2-dependent phosphorylation of actin-capping protein 1 (Acp1, a known regulator of cytokinesis) controls CAR stability, modulates Acp1-Acp2 (the equivalent of the mammalian CAPZA-CAPZB) heterodimer formation and is essential for survival upon stress. Thus, TORC2 localisation to the CAR, and TORC2-dependent Acp1 phosphorylation contributes to timely control and the fidelity of cytokinesis and cell division.

  15. Weakly nonlinear analysis and localised structures in nonlinear cavities with metamaterials

    Science.gov (United States)

    Slimani, N.; Makhoute, A.; Tlidi, M.

    2016-04-01

    We consider an optical ring cavity filled with a metamaterial and with a Kerr medium. The cavity is driven by a coherent radiation beam. The modelling of this device leads to the well known Lugiato-Lefever equation with high order diffraction term. We assume that both left-handed and right-handed materials possess a Kerr focusing type of nonlinearity. We show that close to the zero-diffraction regime, high-order diffraction effect allows us to stabilise dark localised structures in this device. These structures consist of dips or holes in the transverse profile of the intracavity field and do not exist without high-order diffraction effects. We show that high order diffraction effects alter in depth the space-time dynamics of this device. A weakly nonlinear analysis in the vicinity of the first threshold associated with the Turing instability is performed. This analysis allows us to determine the parameter regime where the transition from super- to sub-critical bifurcation occurs. When the modulational instability appears subcritically, we show that bright localised structures of light may be generated in two-dimensional setting. Close to the second threshold associated with the Turing instability, dark localised structures are generated.

  16. An Autonomous Wearable System for Predicting and Detecting Localised Muscle Fatigue

    Directory of Open Access Journals (Sweden)

    Martin Colley

    2011-01-01

    Full Text Available Muscle fatigue is an established area of research and various types of muscle fatigue have been clinically investigated in order to fully understand the condition. This paper demonstrates a non-invasive technique used to automate the fatigue detection and prediction process. The system utilises the clinical aspects such as kinematics and surface electromyography (sEMG of an athlete during isometric contractions. Various signal analysis methods are used illustrating their applicability in real-time settings. This demonstrated system can be used in sports scenarios to promote muscle growth/performance or prevent injury. To date, research on localised muscle fatigue focuses on the clinical side and lacks the implementation for detecting/predicting localised muscle fatigue using an autonomous system. Results show that automating the process of localised muscle fatigue detection/prediction is promising. The autonomous fatigue system was tested on five individuals showing 90.37% accuracy on average of correct classification and an error of 4.35% in predicting the time to when fatigue will onset.

  17. Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation

    Science.gov (United States)

    Seo, Hyeon Gyu; Kim, Han Byeol; Kang, Min Jueng; Ryum, Joo Hwan; Yi, Eugene C.; Cho, Jin Won

    2016-01-01

    Nucleocytoplasmic O-GlcNAc transferase (OGT) attaches a single GlcNAc to hydroxyl groups of serine and threonine residues. Although the cellular localisation of OGT is important to regulate a variety of cellular processes, the molecular mechanisms regulating the nuclear localisation of OGT is unclear. Here, we characterised three amino acids (DFP; residues 451–453) as the nuclear localisation signal of OGT and demonstrated that this motif mediated the nuclear import of non-diffusible β-galactosidase. OGT bound the importin α5 protein, and this association was abolished when the DFP motif of OGT was mutated or deleted. We also revealed that O-GlcNAcylation of Ser389, which resides in the tetratricopeptide repeats, plays an important role in the nuclear localisation of OGT. Our findings may explain how OGT, which possesses a NLS, exists in the nucleus and cytosol simultaneously. PMID:27713473

  18. Causes of accidental childhood deaths in China in 2010: A systematic review and analysis

    Directory of Open Access Journals (Sweden)

    Kit Yee Chan

    2015-06-01

    Full Text Available Background Infectious causes of childhood deaths in the world have decreased substantially in the 21st century. This trend has exposed accidental deaths as an increasingly important future challenge. Presently, little is known about the cause structure of accidental childhood deaths in low– and middle–income country (LMIC settings In this paper, we aim to establish cause structure for accidental deaths in children aged 0–4 years in China in the year 2010. Methods In this paper, we explored the database of 208 multi–cause child mortality studies in Chinese that formed a basis for the first published estimate of the causes of child deaths in China (for the year 2008. Only five of those studies identified specific causes of accidental deaths. Because of this, we searched the Chinese medical literature databases CNKI and WanFang for single–cause mortality studies that were focused on accidental deaths. We identified 71 further studies that provided specific causes for accidental deaths. We used epidemiological modeling to estimate the number of accidental child deaths in China in 2010 and to assign those deaths to specific causes. Results In 2010, we estimated 314 581 deaths in children 0–4 years in China, of which 31 633 (10.1% were accidental. Accidental deaths contributed 7240 (4.0% of all deaths in neonatal period, 8838 (10.5% among all post–neonatal infant deaths, and 15 554 (31.7% among children with 1–4 years of age. Among four tested models, the most predictive was used to establish the likely cause structure of accidental deaths in China. We estimated that asphyxia caused 9490 (95% confidence interval (CI 8224–11 072, drowning 5694 (95% CI 5061–6327, traffic accidents 3796 (95% CI3163–4745, poisoning 3163 (95% CI 2531–3796 and falls 2531 (95% CI 2214–3163 deaths. Based on medians from a few rare studies, we also predict 633 (95% CI 316–1265 deaths to be due to burns and 316 (95% CI 0–633 due to falling objects

  19. Development of a prototype of the tele-localisation system in radiotherapy using personal digital assistant via wireless communication.

    Science.gov (United States)

    Wu, Vincent Wing-Cheung; Tang, Fuk-hay; Cheung, Wai-kwan; Chan, Kit-chi

    2013-02-01

    In localisation of radiotherapy treatment field, the oncologist is present at the simulator to approve treatment details produced by the therapist. Problems may arise if the oncologist is not available and the patient requires urgent treatment. The development of a tele-localisation system is a potential solution, where the oncologist uses a personal digital assistant (PDA) to localise the treatment field on the image sent from the simulator through wireless communication and returns the information to the therapist after his or her approval. Our team developed the first tele-localisation prototype, which consisted of a server workstation (simulator) for the administration of digital imaging and communication in medicine localisation images including viewing and communication with the PDA via a Wi-Fi network; a PDA (oncologist's site) installed with the custom-built programme that synchronises with the server workstation and performs treatment field editing. Trial tests on accuracy and speed of the prototype system were conducted on 30 subjects with the treatment regions covering the neck, skull, chest and pelvis. The average time required in performing the localisation using the PDA was less than 1.5 min, with the blocked field longer than the open field. The transmission speed of the four treatment regions was similar. The average physical distortion of the images was within 4.4% and the accuracy of field size indication was within 5.3%. Compared with the manual method, the tele-localisation system presented with an average deviation of 5.5%. The prototype system fulfilled the planned objectives of tele-localisation procedure with reasonable speed and accuracy.

  20. Pre-treatment nomogram for biochemical control after neoadjuvant androgen deprivation and radical radiotherapy for clinically localised prostate cancer

    OpenAIRE

    Parker, C. C.; Norman, A R; Huddart, R A; Horwich, A; Dearnaley, D. P.

    2002-01-01

    Phase III studies have demonstrated the clinical benefit of adding neo-adjuvant androgen deprivation to radical radiotherapy for clinically localised prostate cancer. We have developed a nomogram to describe the probability of PSA control for patients treated in this way. Five hundred and seventeen men with clinically localised prostate cancer were treated with 3–6 months of neo-adjuvant androgen deprivation and radical radiotherapy (64 Gy in 32#) between 1988 and 1998. Median presenting PSA ...

  1. Workforce localisation policies in multi-national enterprises: the determinants of successful implementation in the Kingdom of Saudi Arabia

    OpenAIRE

    Alanezi, Abdullah N.

    2014-01-01

    This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University London Workforce Localisation policies in Saudi Arabia (commonly known as ‘Saudisation’) have passed their nineteenth year, aiming at replacing foreign employees in the private sector with local employees. The government’s rationale behind the localisation of the workforce includes both the high rate of unemployment amongst Saudi nationals and the massive presence of expatriates in the labo...

  2. Optimal pressure sensor placement for leak localisation using a relaxed isolation index : application to the Barcelona water network

    OpenAIRE

    Cugueró Escofet, Miquel Àngel; Puig Cayuela, Vicenç; Quevedo Casín, Joseba Jokin; Blesa Izquierdo, Joaquim

    2015-01-01

    Water distribution networks are large complex systems that are affected by leaks, which often entail high costs and may severely jeopardize the overall water distribution performance. Successful leak localisation is paramount in order to minimize the impact of these leaks when occurring. Sensor placement is a key issue in the leak localisation process, since the overall performance and success of the leak isolation method highly depends on the choice of the sensors gathering data from the net...

  3. Food irradiation makes progress

    Energy Technology Data Exchange (ETDEWEB)

    Kooij, J. van (Joint FAO/IAEA Div. of Isotope and Radiation Applications of Atomic Energy for Food and Agricultural Development, Vienna (Austria))

    1984-06-01

    In the past fifteen years, food irradiation processing policies and programmes have been developed both by a number of individual countries, and through projects supported by FAO, IAEA and WHO. These aim at achieving general acceptance and practical implementation of food irradiation through rigorous investigations of its wholesomeness, technological and economic feasibility, and efforts to achieve the unimpeded movement of irradiated foods in international trade. Food irradiation processing has many uses.

  4. Patterns and Trends in Accidental Poisoning Deaths: Pennsylvania's Experience 1979-2014.

    Directory of Open Access Journals (Sweden)

    Lauren C Balmert

    Full Text Available The purpose of this study was to examine county and state-level accidental poisoning mortality trends in Pennsylvania from 1979 to 2014.Crude and age-adjusted death rates were formed for age group, race, sex, and county for accidental poisonings (ICD 10 codes X40-X49 from 1979 to 2014 for ages 15+ using the Mortality and Population Data System housed at the University of Pittsburgh. Rate ratios were calculated comparing rates from 1979 to 2014, overall and by sex, age group, and race. Joinpoint regression was used to detect statistically significant changes in trends of age-adjusted mortality rates.Rate ratios for accidental poisoning mortality in Pennsylvania increased more than 14-fold from 1979 to 2014. The largest rate ratios were among 35-44 year olds, females, and White adults. The highest accidental poisoning mortality rates were found in the counties of Southwestern Pennsylvania, those surrounding Philadelphia, and those in Northeast Pennsylvania near Scranton.The patterns and locations of accidental poisoning mortality by race, sex, and age group provide direction for interventions and policy makers. In particular, this study found the highest rate ratios in PA among females, whites, and the age group 35-44.

  5. Childhood death attributable to trauma: is there a difference between accidental and abusive fatal injuries?

    Science.gov (United States)

    Ortega, Henry W; Vander Velden, Heidi; Kreykes, Nathaniel S; Reid, Samuel

    2013-09-01

    Trauma is a leading cause of death among children worldwide. Detailed knowledge of the epidemiology of childhood fatal injuries is necessary for preventing injuries. To determine clinical differences between children who were treated in an emergency department for accidental or abusive injuries. A retrospective review of all deceased patients who were treated in two urban pediatric emergency departments between 1998 and 2010 was performed. Patients were categorized into two groups, accidental and abusive, for comparison. A total of 1498 patients died during the study period, with 124 deaths being attributable to injury for a rate of 9.5 injury-related deaths per year. Most fatal injuries were accidental. Children with abusive fatal injuries were younger and more likely to have been seen for an injury in a clinic or emergency department within 2 months of their death. Eighty-two percent of abusive fatal injuries had documented subdural hematomas, whereas only 7.2% of accidental fatal injuries had a subdural hematoma documented. Nearly 50% of abusive fatal injuries had retinal hemorrhages reported, although no child with an accidental fatal injury had this type of injury documented. Younger children, especially those previously seen in an emergency department or clinic for injury, are more likely to sustain an abusive fatal injury. Sentinel physical findings associated with abusive fatal injuries include subdural hematomas and retinal hemorrhages, and the presence of these findings should prompt an investigation into the circumstances of injury. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Temporal and regional variations in accidental deaths of elderly people in Japan.

    Science.gov (United States)

    Kibayashi, Kazuhiko; Shimada, Ryo; Nakao, Ken-Ichiro

    2013-07-01

    To ascertain the characteristics of accidental deaths of elderly people in urban and rural areas, we analyzed the deaths of elderly people over the 10-year period from 2000 to 2009, in three geographic areas: nationwide, in the 23 wards of the metropolis of Tokyo, and in Saga prefecture. In addition, to assess the regional variation in accidental deaths of the elderly, we aggregated the numbers of accidental deaths of elderly people for each of Japan's prefectures in the year 2009 and categorized the deaths by accident type. The results showed that nationwide, deaths due to threats to breathing, falls, and drowning and submersion are increasing, while deaths due to transport accidents are decreasing, indicating a need for measures to prevent deaths from accidents other than transport accidents. In the urban areas of Tokyo's 23 wards, there is an increasing incidence of deaths due to falls, which is likely due to the high number of structures such as buildings and railway stations that elderly people need to negotiate. In urban areas, measures to reduce the incidence of accidental deaths need to focus on improving the physical environment to help prevent falls. In the rural locality of Saga prefecture, increasing numbers of elderly people are dying by drowning and submersion. The results of analysis of accidents in all prefectures of Japan by accident type show that the causes of accidental deaths of elderly people vary regionally, suggesting that accident prevention measures for elderly people need to consider the characteristics of the locality.

  7. Food irradiation in China

    Energy Technology Data Exchange (ETDEWEB)

    Wedekind, L.

    1986-08-01

    The paper concerns food irradiation in The People's Republic of China. Its use is envisaged to prolong storage times and to improve the quality of specific foodstuffs. Commercialisation in China, demonstration plants, seasonal shortages and losses, Shanghai irradiation centre, health and safety approval, prospects for wider applications and worldwide use of food irradiation, are all discussed.

  8. 基于智能手机的室内定位%INDOOR LOCALISATION BASED ON SMARTPHONE

    Institute of Scientific and Technical Information of China (English)

    赵宇; 周文刚

    2015-01-01

    针对基于 wifi 指纹的室内定位中存在的定位精度不高的问题,提出一套基于加权三点定位的 wifi 指纹定位系统。首先利用最近邻匹配方法进行 wifi 指纹定位,选择出参考点;其次利用多个参考点进行加权三点定位。实验表明,相对于单独使用 wifi指纹定位技术,该系统可以有效提高室内定位的精度和稳定性,并具有较高的实时性。%Considering the problem of lower accuracy of the indoor localisation using Wi-Fi fingerprints technology,we propose a weighed three-point fix-based Wi-Fi fingerprints localisation system.Firstly,we use nearest neighbour matching method to make Wi-Fi fingerprints localisation and chose reference points.Secondly,we use multiple reference points to conduct weighted three-point fix in localisation. Experiments demonstrate that relative to the localisation system using Wi-Fi fingerprints alone,the proposed system can effectively improve the accuracy and stability of indoor localisation,and the real-time property is satisfied as well.

  9. Tratamiento de Terapia Ocupacional en el accidente cerebrovascular

    Directory of Open Access Journals (Sweden)

    Domingo García, AM

    2006-02-01

    Full Text Available RESUMENEntre los muchos pacientes que necesitan tratamiento rehabilitador en Terapia Ocupacional están los que en la edad adulta han sufrido un accidente cerebrovascular.Uno de los factores de riesgo asociados con más frecuencia a las alteraciones del sistema nervioso central es el progresivo envejecimiento de la población, debido a esto orientaré el siguiente artículo hacia la intervención sobre la población geriátrica.La Terapia Ocupacional ofrece un tratamiento global que abarca las áreas funcional, motriz, sensorial, perceptivo y cognitiva. No debemos olvidar el asesoramiento realizado al paciente, a la familia y/ o cuidadores sobre el manejo de la persona que ha sufrido un ictus, la adaptación del entorno y la prescripción, uso y manejo de ayudas técnicas cuando sea necesario.Las propuestas terapéuticas que expondré a continuación, no son recetas únicas que se puedan emplear del mismo modo en todos las personas que hayan sufrido un ictus. Con cada paciente será necesario una evaluación individualizada de su situación y una adaptación de la terapia según sus déficit específicos.La meta final de la Terapia Ocupacional es la integración óptima del paciente dentro de su entorno familiar y social, con el mayor grado de autonomía posible.ABSTRACTAmong the patients who need Occupational Therapy’s rehabilitation treatment, there are those who have suffered a cerebrovascular damage when elderly.People’s gradual ageing is one of the risk factors in the nervous central system’s alterations and this is why I am going to write about intervention on geriatric population.The Occupational Therapy’s rehabilitation treatment works on the functional, motor, sensorial, perceptive and cognitive areas. Moreover, we should not forget to advise the patient and his/her family or caregivers about the way of treating ,the environment’s adaptation, the prescription and use of technical aids when needed.The following therapeutic

  10. Integration of irradiation with cytoplasmic incompatibility to facilitate a lymphatic filariasis vector elimination approach

    Directory of Open Access Journals (Sweden)

    Dobson Stephen L

    2009-08-01

    Full Text Available Abstract Background Mass drug administration (MDA is the emphasis of an ongoing global lymphatic filariasis (LF elimination program by the World Health Organization, in which the entire 'at risk' human population is treated annually with anti-filarial drugs. However, there is evidence that the MDA strategy may not be equally appropriate in all areas of LF transmission, leading to calls for the augmentation of MDA with anti-vector interventions. One potential augmentative intervention is the elimination of vectors via repeated inundative releases of male mosquitoes made cytoplasmically incompatible via an infection with Wolbachia bacteria. However, with a reduction in the vector population size, there is the risk that an accidental female release would permit the establishment of the incompatible Wolbachia infection type, resulting in population replacement instead of population elimination. To avoid the release of fertile females, we propose the exposure of release individuals to low doses of radiation to sterilize any accidentally released females, reducing the risk of population replacement. Results Aedes polynesiensis pupae of differing ages were irradiated to determine a radiation dose that results in sterility but that does not affect the survival and competitiveness of males. Laboratory assays demonstrate that males irradiated at a female sterilizing dosage of 40 Gy are equally competitive with un-irradiated males. No effect of irradiation on the ability of Wolbachia to affect egg hatch was observed. Conclusion An irradiation dose of 40 Gy is sufficient to cause female sterility, but has no observed negative effect on male fitness. The results support further development of this approach as a preventative measure against accidental population replacement.

  11. Materiales didácticos para los contenidos de enfermedad y accidente en la etapa infantil

    OpenAIRE

    Bocos Urdiales, Elías Javier

    2015-01-01

    Este trabajo, es una programación didáctica, que responde a la necesidad de crear materiales para la enseñanza dedicada a la actuación y prevención de accidentes y enfermedades tanto en lo personal, como en lo colectivo tanto en el aula como en los pasillos, patio y zonas comunes. En relación a los accidentes se realizaran materiales para la prevención de los accidentes en el ámbito del centro escolar; y además de la prevención daremos pautas de actuación a los alumnos de tal manera que se...

  12. Increasing US mortality due to accidental poisoning: the role of the baby boom cohort.

    Science.gov (United States)

    Miech, Richard; Koester, Steve; Dorsey-Holliman, Brook

    2011-04-01

    In this study we examine whether the recent, sharp increase in mortality in the United States due to accidental poisoning since 2000 is the result of the aging of the baby boom cohort or, instead, a historical trend apparent among decedents of all ages. We conducted an age-period-cohort analysis using data from the US Vital Statistics and the US Census covering the period 1968-2007. The United States population aged 15-64 years. Cause of death and demographic data as recorded on death certificates. The increase in mortality due to accidental poisoning since the year 2000 stems primarily from a historical period effect across all ages for whites, but results in large part from a rate spike in the baby boom cohort among blacks. For all demographic groups baby boomers had higher odds of death due to accidental poisoning than the cohorts that came before and after them. Historical influences acting across all ages led to an increase in accidental poisoning mortality that was almost 10-fold for whites and threefold for blacks over the study period. While the recent, sharp increase in accidental poisoning mortality stems in part from the aging of the baby boom cohort, substantially more of the increase results from influences unique to recent years that have affected all age groups. These results point to the need to bolster overdose prevention programs and policies as the historical increase in accidental poisoning mortality appears to continue unabated. © 2011 The Authors, Addiction © 2011 Society for the Study of Addiction.

  13. Insomnia medication use and the probability of an accidental event in an older adult population

    Directory of Open Access Journals (Sweden)

    Alon Y Avidan

    2010-11-01

    Full Text Available Alon Y Avidan1, Liisa A Palmer2, Justin F Doan3, Robert W Baran31UCLA Department of Neurology, Los Angeles, CA, USA; 2Thomson Reuters, Washington, DC, USA; 3Takeda Global Research and Development Center, Deerfield, IL, USAObjective: This study examined the risk of accidental events in older adults prescribed a sedating antidepressant, long-acting benzodiazepine, short-acting benzodiazepine, and nonbenzodiazepine, relative to a reference group (selective melatonin receptor agonist.Methods: This was a retrospective cohort analysis of older adults (≥65 years with newly initiated pharmacological treatment of insomnia. Data were collected from the Thomson MarketScan® Medicare Supplemental and Coordination of Benefits databases (January 1, 2000, through June 30, 2006. Probit models were used to evaluate the probability of an accidental event.Results: Data were analyzed for 445,329 patients. Patients taking a long-acting benzodiazepine (1.21 odds ratio [OR], short-acting benzodiazepine (1.16 OR, or nonbenzodiazepine (1.12 OR had a significantly higher probability of experiencing an accidental event during the first month following treatment initiation compared with patients taking the reference medication (P < 0.05 for all. A significantly higher probability of experiencing an accidental event was also observed during the 3-month period following the initiation of treatment (1.62 long-acting benzodiazepine, 1.60 short-acting benzodiazepine, 1.48 nonbenzodiazepine, and 1.56 sedating antidepressant; P < 0.05.Conclusions: Older adults taking an SAD or any of the benzodiazepine receptor agonists appear to have a greater risk of an accidental event compared with a reference group taking an MR.Keywords: insomnia, accidental events, benzodiazepine receptor agonist, melatonin receptor agonist, older adults

  14. Comparison of intracranial computed tomographic (CT) findings in pediatric abusive and accidental head trauma

    Energy Technology Data Exchange (ETDEWEB)

    Hymel, K.P. [University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218 (United States); Rumack, C.M. [University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218 (United States); Hay, T.C. [University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218 (United States); Strain, J.D. [University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218 (United States); Jenny, C. [University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218 (United States)

    1997-09-01

    Background. Child abuse specialists rely heavily on diagnostic neuroimaging. Objectives. Study objectives were: (1) to compare the frequencies of six specific intracranial CT abnormalities in accidental and non-accidental pediatric head trauma, and (2) to assess interobserver agreement regarding these CT findings. Materials and methods. Three pediatric radiologists blindly and independently reviewed cranial CT scans of pediatric patients who sustained closed head trauma between 1991 and 1994. All patients were less than 4 years of age. Study cases included thirty-nine (50 %) with non-accidental head trauma and thirty-nine (50 %) with accidental head trauma. Each scan was evaluated for the presence or absence of the following six intracranial findings: (1) interhemispheric falx hemorrhage, (2) subdural hemorrhage, (3) large (non-acute) extra-axial fluid, (4) basal ganglia edema, (5) posterior fossa hemorrhage, and (6) frontal-parietal shearing tear(s). Interobserver agreement was calculated as the percentage of total cases in which all reviewers agreed a specific CT finding was present or absent. Diagnosis required independent agreement by all three pediatric radiologists. The frequencies of these six intracranial CT abnormalities were compared between the two study groups by Chi-square analysis and Fisher`s exact test. Results. Interobserver agreement between radiologists was greater than 80 % for all lesions evaluated, with the exception of frontal-parietal shearing tear(s). Interhemispheric falx hemorrhage, subdural hemorrhage, large (non-acute) extra-axial fluid, and basal ganglia edema were discovered significantly more frequently in non-accidental trauma (P {<=}.05). Conclusion. Although not specific for child abuse, discovery of these intracranial CT abnormalities in young patients should prompt careful evaluation of family and injury circumstances for indicators of non-accidental trauma. (orig.). With 6 figs., 2 tabs.

  15. Fire-eater's pneumonia: two case reports of accidentally aspirated paraffin oil.

    Science.gov (United States)

    Yigit, Ozlem; Bektas, Fırat; Sayrac, Ali Vefa; Senay, Engin

    2012-04-01

    Fire-eater's pneumonia is a chemical pneumonitis that can develop after accidental aspiration of liquid hydrocarbon-based fuel during a flame-blowing or a fire-eating performance. Typical findings of the patient are similar with any infectious pneumonia: chest pain, shortness of breath, cough, fever, and hemoptysis can be seen. We report two cases of acute paraffin oil-induced pneumonia due to accidental aspiration during fire-eating performance. The symptoms and course of respiratory manifestations and the treatment strategies of fire-eater's pneumonia are reviewed. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Inhaled Surfactant in the treatment of accidental Talc Powder inhalation: a new case report

    Directory of Open Access Journals (Sweden)

    Lo Piparo Caterina

    2011-09-01

    Full Text Available Abstract The use of talcum powder is incorrectly part of the traditional care of infants. Its acute aspiration is a very dangerous condition in childhood. Although the use of baby powder has been discouraged from many authors and the reports of its accidental inhalation have been ever more rare, sometimes new cases with several fatalities have been reported. We report on a patient in which accidental inhalation of baby powder induced severe respiratory difficulties. We also point out the benefits of surfactant administration. Surfactant contributed to the rapid improvement of the medical and radiological condition, preventing severe early and late complications and avoiding invasive approaches.

  17. El estudio del factor humano en accidentes de aviación

    OpenAIRE

    Sánchez Rubio, Lina María

    2010-01-01

    El factor humano ha sido considerado causa o contribución del 70 al 80% de los accidentes de aviación en el mundo, y constituye una prioridad en investigación para la seguridad aérea. Las estadísticas muestran que los índices y causas de accidentes de aviación se mantienen constantes, e identifican una importante diferencia entre regiones. La investigación científica requiere de nuevas y complementarias aproximaciones para la explicación y comprensión del factor humano en aviación. Los médico...

  18. Inhaled surfactant in the treatment of accidental talc powder inhalation: a new case report.

    Science.gov (United States)

    Matina, Federico; Collura, Mirella; Maggio, Maria Cristina; Vitulo, Patrizio; Lo Piparo, Caterina; Corsello, Giovanni

    2011-09-27

    The use of talcum powder is incorrectly part of the traditional care of infants. Its acute aspiration is a very dangerous condition in childhood. Although the use of baby powder has been discouraged from many authors and the reports of its accidental inhalation have been ever more rare, sometimes new cases with several fatalities have been reported. We report on a patient in which accidental inhalation of baby powder induced severe respiratory difficulties. We also point out the benefits of surfactant administration. Surfactant contributed to the rapid improvement of the medical and radiological condition, preventing severe early and late complications and avoiding invasive approaches.

  19. A tunnel shape defect on maxillary bone after accidental injection of formocresol instead of anesthetic solution.

    Science.gov (United States)

    Ege, Bilal; Demirkol, Mehmet; Mustafa, Rawand; Aras, Mutan Hamdi

    2014-09-01

    Accidental injection or leakages of various chemical disinfectants used during root canal preparation into adjacent tissues have been shown to have deleterious effects on surrounding tissue. Formocresol (FC) is an effective intracanal disinfectant used in endodontic procedures. However, it is known to have harmful effects into adjacent tissues. The aim of this article is to present an unusual case in which a 28-year-old male patient developed gingival and bone necrosis after the accidental injection of FC instead of local anesthetic solution for tooth extraction and to review cases in the literature where complications have occurred due to the use of FC.

  20. Studies Relative to the Radiosensitivity of Man: Based on Retrospective Evaluations of Therapeutic and Accidental Total-Body Irradiation

    Science.gov (United States)

    Ricks, R. C. (Compiler); Lushbaugh, C. C. (Compiler)

    1975-01-01

    The radiobiologic studies carried out with joint (AEC) ERDA and NASA support during the years 1964 to 1974 at the Medical Division of Oak Ridge Associated Universities are presented. The physiologic data generated were similar in many ways to those previously observed in other medical radiobiologic experiences. They differed, however, in the methods of data acquisition and analysis. Instead of more conventional analytical methods, pulmonary impedance was recorded and quantitated as a measure of radiation-induced gastrointestinal distress and fatiguability. While refinements in dose response related to gastrointestinal distress were accomplished, it was also found that through the use of Fourier analysis of pulmonary impedance waveform GI distress could easily be recognized and quantified even when the initial stages of nausea were below the subjects subjective level of recognition. The results demonstrate that change in pulmonary impedance waveform closely parallel well-defined stages of GI distress, i.e., initial nausea, a progressive increase in nausea, and finally vomiting episodes.

  1. ESR dosimetry using eggshells and tooth enamel for accidental dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Oka, Toshihide; Yamanaka, Chihiro; Ikeya, Motoji [Department of Earth and Space Science, Faculty of Science, Osaka Univ., Toyonaka, Osaka (Japan)

    1997-07-01

    The CO{sub 2}{sup -} signal of eggshells showed a good dose linearity and was appropriate in the wide dose range from 1 to 10 kGy, while ESR signal of CO{sub 2}{sup -} in sea and fresh water shells were saturated at a dose od below 10 kGy. The minimum detectable dose and G-value of CO{sub 2}{sup -} in eggshells were estimated 0.3 Gy and 0.28, respectively. The lifetime of CO{sub 2}{sup -} in eggshells could not be determined exactly because of overlapping organic signals, however it is still sufficiently long for practical use as ESR dosimeter materials. Various bird`s or reptile`s eggshells would be available as natural retrospective ESR dosimeter materials after nuclear accidents. Eggshells will be useful for the food irradiation dosimetry in the dose range of about a few kGy. Tooth enamel is one of the most useful dosimeter materials in public at a accident because of its high sensitivity. ESR dosimetry will replace TLD in near future if the cost of an ESR reader is further reduced . (author)

  2. Accidentes ocupacionales y conocimiento sobre precauciones universales en internos universitarios costarricenses

    Directory of Open Access Journals (Sweden)

    Álvaro Rivera-Valdivia

    2005-04-01

    Full Text Available Justificación y objetivo: los internos universitarios (estudiantes de medicina en su último año son vulnerables a accidentes ocupacionales con agujas y otros objetos cortantes, especialmente debido a su inexperiencia y falta de entrenamiento aunados a su deseo de realizar una serie de nuevas actividades y procedimientos. No existe información en nuestro país con respecto a la frecuencia de este tipo de accidentes en internos universitarios de la carrera de medicina. El objetivo del presente estudio fue estudiar la frecuencia y tipo de accidentes ocupacionales sufridos con mayor frecuencia por internos de medicina y evaluar su conocimiento sobre precauciones universales. Metodología: Se realizó un estudio descriptivo de corte transversal a través de una encuesta directa y anónima. De todos los internos de medicina que trabajaban en el Valle Central de octubre de 2001 a enero de 2002 se seleccionó una muestra aleatoria de 201 internos (poder 95%, error 5%. A la población seleccionada se le aplicó una encuesta precodificada, la cual consistía en 20 preguntas estructuradas, la mayoría cerradas y tres abiertas relacionadas con la ocurrencia de accidentes ocupacionales en los médicos internos, número, tipo, acciones tomadas tras el accidente y conocimientos sobre precauciones universales. Posteriormente se hizo un análisis descriptivo de los resultados obtenidos. Resultados: de todos los participantes, 90% habían trabajado más de 3 meses como médicos internos. Más de la mitad habían realizado al menos 3 meses de rotación en una área médica y 3 meses en una área quirúrgica. La muestra incluyó estudiantes de 5 universidades diferentes. Sólo un 37% de los internos encuestados habían recibido la vacunación contra virus de la hepatitis B. Del total de internos, 64% admitió haber sufrido al menos un accidente ocupacional con sangre de algún paciente, un 20% admitió haber sufrido 3 o 4 accidentes. De los internos que

  3. Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates

    Directory of Open Access Journals (Sweden)

    A Daniel Bird

    2017-09-01

    Full Text Available Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The type 1 and 2 11-beta hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 2 have key roles in the pre-receptor modification of glucocorticoids allowing aldosterone regulation of blood pressure, control of systemic fluid and electrolyte homeostasis and modulation of integrated metabolism and brain function. Although the activity and function of 11β-HSDs is thought to be understood, there exists an open reading frame for a distinct 11βHSD-like gene; HSD11B1L, which is present in human, non-human primate, sheep, pig and many other higher organisms, whereas an orthologue is absent in the genomes of mouse, rat and rabbit. We have now characterised this novel HSD11B1L gene as encoded by 9 exons and analysis of EST library transcripts indicated the use of two alternate ATG start sites in exons 2 and 3, and alternate splicing in exon 9. Relatively strong HSD11B1L gene expression was detected in human, non-human primate and sheep tissue samples from the brain, ovary and testis. Analysis in non-human primates and sheep by immunohistochemistry localised HSD11B1L protein to the cytoplasm of ovarian granulosa cells, testis Leydig cells, and gonadatroph cells in the anterior pituitary. Intracellular localisation analysis in transfected human HEK293 cells showed HSD1L protein within the endoplasmic reticulum and sequence analysis suggests that similar to 11βHSD1 it is membrane bound. The endogenous substrate of this third HSD enzyme remains elusive with localisation and expression data suggesting a reproductive hormone as a likely substrate.

  4. EphB4 localises to the nucleus of prostate cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Mertens-Walker, Inga, E-mail: inga.mertenswalker@qut.edu.au [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Lisle, Jessica E. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Nyberg, William A. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Stephens, Carson R. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Burke, Leslie [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Rutkowski, Raphael; Herington, Adrian C.; Stephenson, Sally-Anne [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia)

    2015-04-10

    The EphB4 receptor tyrosine kinase is over-expressed in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis. We report here that EphB4 also resides in the nucleus of prostate cancer cell lines. We used in silico methods to identify a bipartite nuclear localisation signal (NLS) in the extracellular domain and a monopartite NLS sequence in the intracellular kinase domain of EphB4. To determine whether both putative NLS sequences were functional, fragments of the EphB4 sequence containing each NLS were cloned to create EphB4NLS-GFP fusion proteins. Localisation of both NLS-GFP proteins to the nuclei of transfected cells was observed, demonstrating that EphB4 contains two functional NLS sequences. Mutation of the key amino residues in both NLS sequences resulted in diminished nuclear accumulation. As nuclear translocation is often dependent on importins we confirmed that EphB4 and importin-α can interact. To assess if nuclear EphB4 could be implicated in gene regulatory functions potential EphB4-binding genomic loci were identified using chromatin immunoprecipitation and Lef1 was confirmed as a potential target of EphB4-mediated gene regulation. These novel findings add further complexity to the biology of this important cancer-associated receptor. - Highlights: • The EphB4 protein can be found in the nucleus of prostate cancer cell lines. • EphB4 contains two functional nuclear localisation signals. • Chromatin immunoprecipitation has identified potential genome sequences to which EphB4 binds. • Lef1 is a confirmed target for EphB4-mediated gene regulation.

  5. Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals.

    Science.gov (United States)

    Nicholson-Fish, Jessica C; Cousin, Michael A; Smillie, Karen J

    2016-03-01

    The efficient retrieval of synaptic vesicle membrane and cargo in central nerve terminals is dependent on the efficient recruitment of a series of endocytosis modes by different patterns of neuronal activity. During intense neuronal activity the dominant endocytosis mode is activity-dependent endocytosis (ADBE). Triggering of ADBE is linked to calcineurin-mediated dynamin I dephosphorylation since the same stimulation intensities trigger both. Dynamin I dephosphorylation is maximised by a simultaneous inhibition of its kinase glycogen synthase kinase 3 (GSK3) by the protein kinase Akt, however it is unknown how increased neuronal activity is transduced into Akt activation. To address this question we determined how the activity-dependent increases in intracellular free calcium ([Ca(2+)]i) control activation of Akt. This was achieved using either trains of high frequency action potentials to evoke localised [Ca(2+)]i increases at active zones, or a calcium ionophore to raise [Ca(2+)]i uniformly across the nerve terminal. Through the use of either non-specific calcium channel antagonists or intracellular calcium chelators we found that Akt phosphorylation (and subsequent GSK3 phosphorylation) was dependent on localised [Ca(2+)]i increases at the active zone. In an attempt to determine mechanism, we antagonised either phosphatidylinositol 3-kinase (PI3K) or calmodulin. Activity-dependent phosphorylation of both Akt and GSK3 was arrested on inhibition of PI3K, but not calmodulin. Thus localised calcium influx in central nerve terminals activates PI3K via an unknown calcium sensor to trigger the activity-dependent phosphorylation of Akt and GSK3.

  6. Advanced situation awareness with localised environmental community observatories in the Future Internet

    Science.gov (United States)

    Sabeur, Z. A.; Denis, H.; Nativi, S.

    2012-04-01

    The phenomenal advances in information and communication technologies over the last decade have led to offering unprecedented connectivity with real potentials for "Smart living" between large segments of human populations around the world. In particular, Voluntary Groups(VGs) and individuals with interest in monitoring the state of their local environment can be connected through the internet and collaboratively generate important localised environmental observations. These could be considered as the Community Observatories(CO) of the Future Internet(FI). However, a set of FI enablers are needed to be deployed for these communities to become effective COs in the Future Internet. For example, these communities will require access to services for the intelligent processing of heterogeneous data and capture of advancend situation awarness about the environment. This important enablement will really unlock the communities true potential for participating in localised monitoring of the environment in addition to their contribution in the creation of business entreprise. Among the eight Usage Areas(UA) projects of the FP7 FI-PPP programme, the ENVIROFI Integrated Project focuses on the specifications of the Future Internet enablers of the Environment UA. The specifications are developed under multiple environmental domains in context of users needs for the development of mash-up applications in the Future Internet. It will enable users access to real-time, on-demand fused information with advanced situation awareness about the environment at localised scales. The mash-up applications shall get access to rich spatio-temporal information from structured fusion services which aggregate COs information with existing environmental monitoring stations data, established by research organisations and private entreprise. These applications are being developed in ENVIROFI for the atmospheric, marine and biodiversity domains, together with a potential to be extended to other

  7. Aero-/hydro-elastic stability of flexible panels: Prediction and control using localised spring support

    Science.gov (United States)

    Tan, B. H.; Lucey, A. D.; Howell, R. M.

    2013-12-01

    We study the effect of adding localised stiffness, via a spring support, on the stability of flexible panels subjected to axial uniform incompressible flow. Applications are considered that range from the hydro-elasticity of hull panels of high-speed ships to the aero-elasticity of glass panels in the curtain walls of high-rise buildings in very strong winds. A two-dimensional linear analysis is conducted using a hybrid of theoretical and computational methods that calculates the system eigen-states but can also be used to capture the transient behaviour that precedes these. We show that localised stiffening is a very effective means to increase the divergence-onset flow speed in both hydro- and aero-elastic applications. It is most effective when located at the mid-chord of the panel and there exists an optimum value of added stiffness beyond which further increases to the divergence-onset flow speed do not occur. For aero-elastic applications, localised stiffening can be used to replace the more destructive flutter instability that follows divergence at higher flow speeds by an extended range of divergence. The difference in eigen-solution morphology between aero- and hydro-elastic applications is highlighted, showing that for the former coalescence of two non-oscillatory divergence modes is the mechanism for flutter onset. This variation in solution morphology is mapped out in terms of a non-dimensional mass ratio. Finally, we present a short discussion of the applicability of the stabilisation strategy in a full three-dimensional system.

  8. Ecotoxicological assays of Diethyltoluamide and Lemongrass Essencial Oil in irradiated and non-irradiated aquatic organisms

    Energy Technology Data Exchange (ETDEWEB)

    Gimiliani, Giovana T.; Rogero, Sizue O.; Martini, Gisela A.; Rogero, Jose R., E-mail: sorogero@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    Aquatic invertebrates can be potentially exposed to nonradioactive contaminants in conjunction with ionizing radiation, especially in highly industrialized areas surrounding nuclear facilities, where radionuclides can accidentally be discharged in the aquatic environment containing stable chemicals. The aquatic organisms have continually been exposed to chemical contaminants like personal care products (PCPs) which have been found in various environmental matrices and may cause adverse effects to aquatic life and human health as radioactive products. In this study was used C. silvestrii as bioindicator organism in chronic ecotoxicity assays with lemongrass essencial oil (LEO) and Diethyltoluamide (DEET), both are insect repellent. In addition to exposition of the compounds, the organisms were irradiated with gamma rays from Co-60 source. Thus, the aim of this study was to evaluate the possible synergistic effect of gamma radiation and mosquito repellent products in the reproduction of Ceriodaphnia silvestrii utilizing standardized ecotoxicological tests. The C. silvestrii inhibition concentration (IC25; 7 days) result after DEET exposition was 16.4 ± 1.4 mg L{sup -1} and for LEO was 3.1 ± 1.4 mg L{sup -1}. In the irradiated (25 Gy) C. silvestrii exposed to DEET and LEO, the concentration that inhibited reproduction was 16.1 ± 0.9 mg L{sup -1} and 2.4 ± 0.3 mg L{sup -1} respectively. The results showed that the reproduction of irradiated C. silvestrii was not significantly affected when compared with non-irradiated organisms when exposed to DEET or LEO. (author)

  9. 36 CFR 1230.10 - Who is responsible for preventing the unlawful or accidental removal, defacing, alteration, or...

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT UNLAWFUL OR ACCIDENTAL REMOVAL, DEFACING, ALTERATION, OR DESTRUCTION OF RECORDS § 1230.10 Who is... destruction, removal, alteration or defacement of records; (c) Implement and disseminate policies and... preventing the unlawful or accidental removal, defacing, alteration, or destruction of records?...

  10. Intra-operative tumour localisation in robot-assisted minimally invasive surgery: A review.

    Science.gov (United States)

    Li, Min; Liu, Hongbin; Jiang, Allen; Seneviratne, Lakmal D; Dasgupta, Prokar; Althoefer, Kaspar; Wurdemann, Helge

    2014-05-01

    Robot-assisted minimally invasive surgery has many advantages compared to conventional open surgery and also certain drawbacks: it causes less operative trauma and faster recovery times but does not allow for direct tumour palpation as is the case in open surgery. This article reviews state-of-the-art intra-operative tumour localisation methods used in robot-assisted minimally invasive surgery and in particular methods that employ force-based sensing, tactile-based sensing, and medical imaging techniques. The limitations and challenges of these methods are discussed and future research directions are proposed.

  11. Fibre Tip Sensors for Localised Temperature Sensing Based on Rare Earth-Doped Glass Coatings

    Directory of Open Access Journals (Sweden)

    Erik P. Schartner

    2014-11-01

    Full Text Available We report the development of a point temperature sensor, based on monitoring upconversion emission from erbium:ytterbium-doped tellurite coatings on the tips of optical fibres. The dip coating technique allows multiple sensors to be fabricated simultaneously, while confining the temperature-sensitive region to a localised region on the end-face of the fibre. The strong response of the rare earth ions to changing temperature allows a resolution of 0.1–0.3 °C to be recorded over the biologically relevant range of temperatures from 23–39 °C.

  12. Advanced indoor localisation based on the Viterbi algorithm and semantic data

    OpenAIRE

    Trogh, Jens; Plets, David; Martens, Luc; Joseph, Wout

    2015-01-01

    In this work a real-time indoor localisation system based on the Viterbi algorithm is developed. This Viterbi principle is used in combination with semantic data to improve the accuracy: i.e., the environment of the object that is being tracked and an adjustable maximum speed. The developed algorithm was verified by simulations and with experiments in a building-wide testbed for sensor and WiFi experiments. Compared to a reference algorithm without Viterbi or semantic data, the results indica...

  13. Localised pityriasis rosea-like eruption during radiotherapy. Report of 2 cases.

    Science.gov (United States)

    Moloney, Gary R; Goh, Michelle S Y; Mitchell, Catherine; McCormack, Chris J

    2015-11-01

    Pityriasis rosea is a common skin condition that presents acutely with asymptomatic, scaly and oval plaques, usually in a well-recognised distribution over the trunk. Two men developed ovoid, scaly and annular lesions limited to the radiotherapy field during treatment for pelvic malignancies and without a preceding herald patch. Other causes of the eruption were excluded on clinical and pathological grounds and the histopathological features were consistent with a pityriasis rosea-like eruption. In both cases the lesions resolved spontaneously by 8 weeks. These are the first reported cases of a localised pityriasis rosea-like eruption arising during radiotherapy. © 2014 The Australasian College of Dermatologists.

  14. ROBUST LOCALISATION OF MULTIPLE SPEAKERS EXPLOITING HEAD MOVEMENTS AND MULTI-CONDITIONAL TRAINING OF BINAURAL CUES

    DEFF Research Database (Denmark)

    May, Tobias; Ma, Ning; Brown, Guy

    2015-01-01

    This paper addresses the problem of localising multiple competing speakers in the presence of room reverberation, where sound sources can be positioned at any azimuth on the horizontal plane. To reduce the amount of front-back confusions which can occur due to the sim- ilarity of interaural time...... differences (ITDs) and interaural level dif- ferences (ILDs) in the front and rear hemifield, a machine hearing system is presented which combines supervised learning of binaural cues using multi-conditional training (MCT) with a head movement strategy. A systematic evaluation showed that this approach...

  15. Characterisation of a novel proteolytic enzyme localised to goblet cells in rat and man

    DEFF Research Database (Denmark)

    Poulsen, Steen Seier

    1984-01-01

    for enzymatic activity is 7.4-8.0. Based on substrate specificity for arg-x, lys-x and to a lesser degree tyr-x, on the effect of diisopropylphosphorofluoride , Trasylol and phenylmethylsulfonylfluoride and on proteolytic activity towards intact proteins, ingobsin is classified as a serine proteinase......A proteolytic enzyme, ingobsin , purified from rat duodenal extracts is shown to be localised to intestinal goblet cells of both man and rat. Enzyme positive cells decrease in number from duodenum to colon. The enzyme is a 33 000 Mr protein with an isoelectric point of 5.1. The pH optimum...... with endoproteolytic activity....

  16. The Effect of Interchannel Time Difference on Localisation in Vertical Stereophony

    OpenAIRE

    Wallis, Rory; Lee, Hyunkook

    2015-01-01

    Listening tests were conducted in order to analyse the localisation of band-limited stimuli in vertical stereophony. The test stimuli were seven octave bands of pink noise, with centre frequencies ranging from 125–8000Hz, as well as broadband pink noise. Stimuli were presented from vertically arranged loudspeakers either monophonically or as vertical phantom images, created with the upper loudspeaker delayed with respect to the lower by 0, 0.5, 1, 5 and 10ms (i.e. interchannel time difference...

  17. The Reduction of Vertical Interchannel Crosstalk: The Analysis of Localisation Thresholds for Natural Sound Sources

    OpenAIRE

    Wallis, Rory; Lee, Hyunkook

    2017-01-01

    In subjective listening tests, natural sound sources were presented to subjects as vertically-oriented phantom images from two layers of loudspeakers, ‘height’ and ‘main’. Subjects were required to reduce the amplitude of the height layer until the position of the resultant sound source matched that of the same source presented from the main layer only (the localisation threshold). Delays of 0, 1 and 10 ms were applied to the height layer with respect to the main, with vertical stereophonic a...

  18. How AI localisation in plant tissues determines the targeted pest spectrum of different chemistries

    DEFF Research Database (Denmark)

    Buchholz, Anke; Trapp, Stefan

    penetration as first crucial step can be modified by formulation whereas the active ingredient (AI) distribution within cells is usually solely determined by physicochemical properties. This passive AI distribution was calculated with the Fick-Nernst-Planck equation implemented in a cell model....... The predictions were compared to the measured biological effects against three different arthropods. Test compounds differed in log P (-0.1 to 4.3) and pKa (4.1 to 10.7). Efficacies in different bioassays are discussed with the postulated cellular AI localisation and the individual feeding behaviour...

  19. Intraperitoneal granulomatous foreign body reaction after accidental perforation of the abdominal wall. Case report

    DEFF Research Database (Denmark)

    Lanng, C; Winther-Nielsen, H; Hougen, H P

    2013-01-01

    After an accidental perforation by a wooden stake of the abdominal wall and distal ileum a 28-year-old man developed an aggressive granulomatous foreign body reaction of the greater omentum with high fever and abdominal pain. The patient was cured by omental resection and prednisone treatment....

  20. Abbreviata terrapenis (Nematoda: Physalopteridae): an accidental parasite of the banded rock rattlesnake (Crotalus lepidus klauberi).

    Science.gov (United States)

    Goldberg, Stephen R; Bursey, Charles R; Holycross, Andrew T

    2002-04-01

    The nematode, Abbreviata terrapenis (Physalopteridae) was found in 16 (6%) of 267 banded rock rattlesnakes (Crotalus lepidus klauberi) from Arizona and New Mexico. Abbreviata terrapenis in C. lepidus represents an accidental parasite in that "infection" was acquired by the ingestion of lizard prey. Feeding captive snakes on wild-caught lizards poses a risk of introducing nematodes to the snakes.

  1. The accidental city : violence, economy and humanitarianism in Kakuma refugee camp Kenya

    NARCIS (Netherlands)

    Jansen, B.J.

    2011-01-01

    In this research I examine social ordering processes in Kakuma refugee camp in Kenya. I view the camp as an accidental city, by which I challenge the image of the camp as a temporary and artificial waiting space or a protracted refugee crisis per se. The reference to the city is both

  2. Management of accidental dural puncture and post-dural puncture headache after labour: a Nordic survey

    DEFF Research Database (Denmark)

    Darvish, B; Gupta, A; Alahuhta, S

    2011-01-01

    a major risk with epidural analgesia is accidental dural puncture (ADP), which may result in post-dural puncture headache (PDPH). This survey was conducted to explore the incidence of ADP, the policy for management of PDPH and the educational practices in epidural analgesia during labour...

  3. Accidentes ofídicos en Yopal y Leticia, Colombia, 1996-1997

    Directory of Open Access Journals (Sweden)

    Daniel Pineda

    2002-03-01

    Full Text Available El accidente ofídico presenta un elevado impacto sobre la morbimortalidad en la Amazonia y la Orinoquia colombianas. En este estudio se revisaron prospectivamente los casos ocurridos en los hospitales de Leticia y Yopal durante el período comprendido entre septiembre de 1996 y junio de 1997. El 57% de los accidentes estudiados ocurrieron en Leticia. El 54% de los accidentes se presentaron en hombres y el grupo de edad más comprometido fue el de 15 a 44 años (41%. El 57% de los casos ocurrió a campo abierto y el pico de accidentalidad se presentó entre las 17 y las 18 horas. El 82% de las mordeduras fue en miembros inferiores. Se presentó un fallecimiento (1,8% en Yopal y se practicaron 3 fasciotomías y 2 amputaciones; el 16% de los casos presentó infección secundaria. Las horas vespertinas presentan el mayor riesgo de accidente durante la jornada diaria. A pesar del uso generalizado de antibióticos, la infección secundaria fue frecuente en esta serie de casos.

  4. The accidental city : violence, economy and humanitarianism in Kakuma refugee camp Kenya

    NARCIS (Netherlands)

    Jansen, B.J.

    2011-01-01

    In this research I examine social ordering processes in Kakuma refugee camp in Kenya. I view the camp as an accidental city, by which I challenge the image of the camp as a temporary and artificial waiting space or a protracted refugee crisis per se. The reference to the city is both metaphorical

  5. Estrategia de Inversiones Basada en Accidentes Aéreos: ¿Hay Retornos Anormales?

    Directory of Open Access Journals (Sweden)

    Marcos Rosa Costa

    2013-06-01

    Full Text Available El presente trabajo buscó investigar si una estrategia de inversiones basada en accidentes aéreos generaría retornos anormales. Fue efectuado un estudio de eventos considerándose todos los accidentes aéreos ocurridos en el período de 1998 a 2009 y los datos de las compañías aéreas y de los fabricantes de las respectivas aeronaves que poseían acciones negociadas en las bolsas de valores, cuando del acontecimiento del evento. Los tests realizados se basaron en el modelo de Campbel, Lo y Mackinlay (1997, para definición de retornos anormales, por medio de una regresión lineal entre el retorno de las acciones de esas empresas y el retorno del portafolio de mercado utilizado como benchmark. Así fue posible proyectar los retornos futuros esperados para las acciones de las compañías aéreas y fabricantes y compararlos a los resultados efectivamente obtenidos en el acontecimiento del evento. El resultado obtenido sugiere que una estrategia de inversiones basada en accidentes aéreos sería viable y que retornos anormales podrían ser obtenidos en el período inmediatamente posterior a un accidente aéreo.

  6. The Costs of Cultural Change: Accidental Injury and Modernization among the Papago Indians

    Science.gov (United States)

    Hackenberg, Robert A.; Gallagher, Mary M.

    1972-01-01

    Several theories are examined suggesting that stress associated with modernization is responsible for excesses of accidental injuries among American Indians. A preliminary version of this paper was presented at the annual meetings of the American Anthropological Association, New York, 1971. (FF)

  7. INTERNAL BALLOON TAMPONADE - A NONSURGICAL METHOD FOR REMOVAL OF ACCIDENTALLY PLACED SHEATHS FROM THE SUBCLAVIAN ARTERY

    NARCIS (Netherlands)

    VANDIJK, RB; DENHEIJER, P; DEMUINCK, E; LIE, KI

    1993-01-01

    One of the possible complications of subclavian vein puncture is accidental puncture of the subclavian artery. If this is not noted immediately after the puncture, insertion of a large bore sheath in the subclavian artery is likely to follow. We describe our experience with a new method that enables

  8. Accidental Epipen injection into a digit - the value of a Google search.

    Science.gov (United States)

    Turner, M. J. A.; Purushotham, A. D.

    2004-01-01

    Despite the lack of awareness by the clinicians consulted of the most suitable treatment for accidentally injected epinephrine, this patient was successfully treated due mainly to the ability of clinicians on-site to access the Internet in the A&E department. A broad search engine such as Google can be an invaluable tool in finding important clinical information rapidly. PMID:15140311

  9. Accidental Epipen injection into a digit - the value of a Google search.

    Science.gov (United States)

    Turner, M J A; Purushotham, A D

    2004-05-01

    Despite the lack of awareness by the clinicians consulted of the most suitable treatment for accidentally injected epinephrine, this patient was successfully treated due mainly to the ability of clinicians on-site to access the Internet in the A&E department. A broad search engine such as Google can be an invaluable tool in finding important clinical information rapidly.

  10. [Accidental injection of adrenaline in a finger with EpiPen].

    Science.gov (United States)

    Kaspersen, J; Vedsted, P

    1998-11-01

    We report a case of accidental injection of 0.3 mg epinephrine in the right pollux. The actual case was treated with systemic nitroglyceride and immersion of the finger in hot water. A review of the literature shows that the adequate treatment is local infiltration with Phentholamine Mesylate. There is a need to describe this treatment in conventional literature.

  11. Tratamiento de la hipertensión arterial en accidente cerebrovascular

    OpenAIRE

    Luna Vela, Fredy Andrés

    2013-01-01

    Revisión sistemática de la literatura en la que se discuten las controversias del manejo de la presión arterial en las emergencias neurológicas agudas cerebrovasculares como accidente cerebrovascular isquémico, hemorrágico y hemorragia subaracnoidea.

  12. Youth versus adult "weightlifting" injuries presenting to United States emergency rooms: accidental versus nonaccidental injury mechanisms.

    Science.gov (United States)

    Myer, Gregory D; Quatman, Carmen E; Khoury, Jane; Wall, Eric J; Hewett, Timothy E

    2009-10-01

    Resistance training has previously been purported to be unsafe and ineffective in children. The purpose of this investigation was to evaluate resistance training-related injuries presenting to U.S. emergency rooms by age, type, and mechanism of injury. We hypothesized that older athletes would sustain greater percentages of joint sprains and muscle strains, whereas younger athletes would sustain a greater percentage of accidental injuries that would result in an increased percentage of fractures in youths. The U.S. Consumer Product Safety Commission (CPSC) National Electronic Injury Surveillance System was queried from 2002 to 2005 using the CPSC code for "Weightlifting." Subjects between the ages of 8 and 30 were grouped by age categories 8 to 13 (elementary/middle school age), 14 to 18 (high school), 19 to 22 (college), and 23 to 30 (adult). Injuries were classified as "accidental" if caused by dropped weight or improper equipment use. Multiple logistic regression was used to compare accidental injuries between age groups. The sample consisted of 4,111 patients. Accidental injuries decreased (p 14 to 18 > 19 to 22 years = 23 to 30 years. Conversely, sprain/strain injuries increased in each successive age group (p children have lower risk of resistance training-related joint sprains and muscle strains than adults. The majority of youth resistance training injuries are the result of accidents that are potentially preventable with increased supervision and stricter safety guidelines.

  13. Insertion of an intrathecal catheter following accidental dural puncture : a meta-analysis

    NARCIS (Netherlands)

    Heesen, M.; Kloehr, S.; Rossaint, R.; Walters, M.; Straube, S.; van de Velde, M.

    2013-01-01

    Background: Inserting an intrathecal catheter after accidental dural puncture in parturients to prevent postdural puncture headache is becoming increasingly popular. We aimed to identify relevant published articles investigating this intervention and subject data to a meta-analysis. Methods: A syste

  14. INTERNAL BALLOON TAMPONADE - A NONSURGICAL METHOD FOR REMOVAL OF ACCIDENTALLY PLACED SHEATHS FROM THE SUBCLAVIAN ARTERY

    NARCIS (Netherlands)

    VANDIJK, RB; DENHEIJER, P; DEMUINCK, E; LIE, KI

    One of the possible complications of subclavian vein puncture is accidental puncture of the subclavian artery. If this is not noted immediately after the puncture, insertion of a large bore sheath in the subclavian artery is likely to follow. We describe our experience with a new method that enables

  15. Multiple scattering and accidental coincidences in the J-PET detector simulated using GATE package

    CERN Document Server

    Kowalski, P; Wiślicki, W; Raczyński, L; Bednarski, T; Białas, P; Bułka, J; Czerwiński, E; Gajos, A; Gruntowski, A; Kamińska, D; Kapłon, Ł; Kochanowski, A; Korcyl, G; Kowal, J; Kozik, T; Krzemień, W; Kubicz, E; Niedźwiecki, Sz; Pałka, M; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Słomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wochlik, I; Zieliński, M; Zoń, N

    2015-01-01

    Novel Positron Emission Tomography system, based on plastic scintillators, is developed by the J-PET collaboration. In order to optimize geometrical configuration of built device, advanced computer simulations are performed. Detailed study is presented of background given by accidental coincidences and multiple scattering of gamma quanta.

  16. [Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)

    NARCIS (Netherlands)

    Hameleers-Snijders, P.; Hogeveen, M.; Smeitink, J.A.M.; Kramers, C.; Draaisma, J.M.T.

    2007-01-01

    Two girls aged 4 and 3 years, respectively, experienced acute liver failure due to accidental ingestion of supratherapeutic doses of paracetamol (90 mg/kg/day or more). Recognition of chronic paracetamol intoxication as a cause of acute hepatic failure is often delayed. It is important to consider t

  17. La configuraci??n jur??dica del accidente de trabajo

    OpenAIRE

    S??nchez P??rez, Jos??

    2013-01-01

    Esta obra incorpora un an??lisis global del accidente de trabajo y su configuraci??n jur??dica. Analiza su evoluci??n hist??rica e incorpora una selecci??n de m??s de 300 sentencias del Tribunal Supremo que permiten identificar su contenido.

  18. [Factors associated with the danger of accidental falls among institutionalized elderly individuals: an integrative review].

    Science.gov (United States)

    Gomes, Erika Carla Cavalcanti; Marques, Ana Paula de Oliveira; Leal, Márcia Carréra Campos; Barros, Benvinda Pereira de

    2014-08-01

    The scope of this research is to identify the major risk factors associated with accidental falls among the elderly. It involves an integrative review of the literature between 2002 and 2012 in English and Portuguese. The selection of articles was based on the following key words in the Lilacs, Medline and BDENF databases: accidental falls, homes for the elderly and health services. In the final sample 19 articles were selected, of which 11 were national and 8 were international. They indicate that the major factors related to the risk of accidental falls in Homes for the Elderly are: being female, being diagnosed with chronic disease, treatment with benzodiazepine, earlier cases of accident falls, and mobility restriction. The research reveals that architectonic and furniture inadequacies in Homes for the Elderly may be predisposing factors for accidental falls. Analysis of the articles reveals the need for further longitudinal studies and, consequently, enhanced monitoring of the conditions of the functional capacity of the elderly, especially the risks related to falls, considered one of the leading causes of death among institutionalized elderly individuals.

  19. High dose ionizing irradiation induces an early and transient increase in peripheral blood hematopoietic progenitor cells; L`exposition aigue aux radiations ionisantes induit un recrutement transitoire des progeniteurs hematopoietiques au niveau du sang peripherique: implications therapeutiques potentielles

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Vetillard, J.; Chauvelot, F.; Thierry, D.; Mestries, J.C.; Herodin, F. [Centre de Recherches du Service de Sante des Armees, La Tronche, 38 - Grenoble (France)]|[Centre de Recherches du Service de Sante des Armees - Centre d`Etudes Nucleaires de Fontenay-aux-Roses, 92 (France)

    1997-12-31

    Nonhuman primates exposed to ionizing radiation exhibit an early and transient increase in peripheral blood committed hematopoietic progenitor cells. The management of bone marrow aplasia secondary to accidental irradiation could be based in part on the re-infusion of those circulating autologous progenitors following a period of ex vivo expansion with cytokines. (authors)

  20. The Reduction of Vertical Interchannel Crosstalk: The Analysis of Localisation Thresholds for Natural Sound Sources

    Directory of Open Access Journals (Sweden)

    Rory Wallis

    2017-03-01

    Full Text Available In subjective listening tests, natural sound sources were presented to subjects as vertically-oriented phantom images from two layers of loudspeakers, ‘height’ and ‘main’. Subjects were required to reduce the amplitude of the height layer until the position of the resultant sound source matched that of the same source presented from the main layer only (the localisation threshold. Delays of 0, 1 and 10 ms were applied to the height layer with respect to the main, with vertical stereophonic and quadraphonic conditions being tested. The results of the study showed that the localisation thresholds obtained were not significantly affected by sound source or presentation method. Instead, the only variable whose effect was significant was interchannel time difference (ICTD. For ICTD of 0 ms, the median threshold was −9.5 dB, which was significantly lower than the −7 dB found for both 1 and 10 ms. The results of the study have implications both for the recording of sound sources for three-dimensional (3D audio reproduction formats and also for the rendering of 3D images.

  1. Scintigraphic techniques in primary hyperparathyroidism: from pre-operative localisation to intra-operative imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rubello, Domenico [S. Maria della Misericordia Hospital, Service of Nuclear Medicine, Rovigo (Italy); Gross, Milton D. [Department of Veterans Affairs Health System, Nuclear Medicine Service, Ann Arbor, MI (United States); Mariani, Giuliano [University of Pisa, Regional Center of Nuclear Medicine, Pisa (Italy); Al-Nahhas, Adil [Hammersmith Hospital, Department of Nuclear Medicine, London (United Kingdom)

    2007-06-15

    Primary hyperparathyroidism (PHPT) is an increasingly diagnosed disease worldwide. In most cases, PHPT is related to the presence of a solitary parathyroid adenoma (PA). Fifty percent or more of newly diagnosed PHPT patients are asymptomatic, and there is debate among endocrinologists and endocrine surgeons about whether or not such patients should be treated. Usually, in a PHPT patient with a solitary PA that is well localised pre-operatively, a parathyroidectomy with limited or minimally invasive neck exploration is offered. The diffusion of minimally invasive neck exploration procedures is a consequence of the significant improvement in the accuracy of pre-operative imaging (mainly scintigraphic) techniques; these techniques have changed the surgical strategy to PHPT, from the wide traditional bilateral neck exploration to limited neck exploration. The present review considers developments during the past 10-15 years with regard to both the accuracy of pre-operative localising imaging techniques and intra-operative minimally invasive procedures in order to provide endocrinologists and endocrine surgeons with further information about the newly available diagnostic and therapeutic tools for use in PHPT patients with a solitary PA. (orig.)

  2. Organisation as a key factor in Localised Agri-Food Systems (LAFS

    Directory of Open Access Journals (Sweden)

    Corrado Giacomini

    2015-05-01

    Full Text Available Most studies of Localised Agri-Food Systems (LAFS focus on the localised concentration of members and firms, and pay less attention to organisational factors, particularly those of an exogenous nature. This paper focuses on the role of organisation in a LAFS, assessing the efficacy of EU organisational measures aimed at strengthening the concentration of supply from the recent CAP reform 2014-2020. The paper has three sections. Part One describes the evolution of the concept of LAFS. Part Two examines the leading role played by institutions in organising relationships between firms in a LAFS. The example provided is that of the measures affecting the organisation of supply introduced by the recent CAP reform, 2014-2020. It makes particular reference to the Distretto del pomodoro da industria – Nord Italia (‘Industrial Tomato District – Northern Italy’. Part Three describes how organisational factors can lead to the creation of a LAFS, while the criterion of proximity is necessary but not sufficient.

  3. Ecosystem Service Potentials, Flows and Demands – Concepts for Spatial Localisation, Indication and Quantification

    Directory of Open Access Journals (Sweden)

    Benjamin Burkhard

    2014-06-01

    Full Text Available The high variety of ecosystem service categorisation systems, assessment frameworks, indicators, quantification methods and spatial localisation approaches allows scientists and decision makers to harness experience, data, methods and tools. On the other hand, this variety of concepts and disagreements among scientists hamper an integration of ecosystem services into contemporary environmental management and decision making. In this article, the current state of the art of ecosystem service science regarding spatial localisation, indication and quantification of multiple ecosystem service supply and demand is reviewed and discussed. Concepts and tables for regulating, provisioning and cultural ecosystem service definitions, distinguishing between ecosystem service potential supply (stocks, flows (real supply and demands as well as related indicators for quantification are provided. Furthermore, spatial concepts of service providing units, benefitting areas, spatial relations, rivalry, spatial and temporal scales are elaborated. Finally, matrices linking CORINE land cover types to ecosystem service potentials, flows, demands and budget estimates are provided. The matrices show that ecosystem service potentials of landscapes differ from flows, especially for provisioning ecosystem services.

  4. Smart-aggregation imaging for single molecule localisation with SPAD cameras.

    Science.gov (United States)

    Gyongy, Istvan; Davies, Amy; Dutton, Neale A W; Duncan, Rory R; Rickman, Colin; Henderson, Robert K; Dalgarno, Paul A

    2016-11-23

    Single molecule localisation microscopy (SMLM) has become an essential part of the super-resolution toolbox for probing cellular structure and function. The rapid evolution of these techniques has outstripped detector development and faster, more sensitive cameras are required to further improve localisation certainty. Single-photon avalanche photodiode (SPAD) array cameras offer single-photon sensitivity, very high frame rates and zero readout noise, making them a potentially ideal detector for ultra-fast imaging and SMLM experiments. However, performance traditionally falls behind that of emCCD and sCMOS devices due to lower photon detection efficiency. Here we demonstrate, both experimentally and through simulations, that the sensitivity of a binary SPAD camera in SMLM experiments can be improved significantly by aggregating only frames containing signal, and that this leads to smaller datasets and competitive performance with that of existing detectors. The simulations also indicate that with predicted future advances in SPAD camera technology, SPAD devices will outperform existing scientific cameras when capturing fast temporal dynamics.

  5. Low-frequency variability in idealised GCM experiments with circumpolar and localised storm tracks

    Directory of Open Access Journals (Sweden)

    W. Müller

    2002-01-01

    Full Text Available Idealised global circulation model simulations with circumpolar and localised (one and two storm tracks are re-analysed to determine scaling, intermittency and phase-space structures. In a hundred year experiment with a circumpolar storm track, the spectrum S(f of the first principal component of the zonal wind fluctuations shows the following power law regimes: (a a short-term memory between f- -4 and f  -2 up to 50 days and (b a long-term memory f -1 from 50 to 400 days and f -0.24 beyond 400 days, similar to observed maritime single station near-surface air temperature data. In the presence of localised storm tracks, the wave number two dominates the dynamics and a long-term memory cannot be detected. The recurrence plot is introduced as a novel tool to comprehensively visualise the evolution of the dynamical system in terms of state separations (distances in phase space. The patterns allow for a qualitative interpretation of the underlying local phenomena in phase space, such as waves, analogs, extremes, and global regimes. Attractor dimensions are, in general, larger than 10, but they appear to be lower in the wave-dominated regimes of the double storm track experiment.

  6. Sub-pixel localisation of passive micro-coil fiducial markers in interventional MRI.

    Science.gov (United States)

    Rea, Marc; McRobbie, Donald; Elhawary, Haytham; Tse, Zion T H; Lamperth, Michael; Young, Ian

    2009-04-01

    Electromechanical devices enable increased accuracy in surgical procedures, and the recent development of MRI-compatible mechatronics permits the use of MRI for real-time image guidance. Integrated imaging of resonant micro-coil fiducials provides an accurate method of tracking devices in a scanner with increased flexibility compared to gradient tracking. Here we report on the ability of ten different image-processing algorithms to track micro-coil fiducials with sub-pixel accuracy. Five algorithms: maximum pixel, barycentric weighting, linear interpolation, quadratic fitting and Gaussian fitting were applied both directly to the pixel intensity matrix and to the cross-correlation matrix obtained by 2D convolution with a reference image. Using images of a 3 mm fiducial marker and a pixel size of 1.1 mm, intensity linear interpolation, which calculates the position of the fiducial centre by interpolating the pixel data to find the fiducial edges, was found to give the best performance for minimal computing power; a maximum error of 0.22 mm was observed in fiducial localisation for displacements up to 40 mm. The inherent standard deviation of fiducial localisation was 0.04 mm. This work enables greater accuracy to be achieved in passive fiducial tracking.

  7. Chromosomal localisation and genetic variation of the SLC11A1 gene in goats (Capra hircus).

    Science.gov (United States)

    Vacca, G M; Pazzola, M; Pisano, C; Carcangiu, V; Diaz, M L; Nieddu, M; Robledo, R; Mezzanotte, R; Dettori, M L

    2011-10-01

    The solute carrier family 11 member A1 (SLC11A1) gene is associated with resistance to infectious diseases. Chromosomal localisation, genomic regions corresponding to functional domains and the genetic variability of microsatellites in the 3' untranslated region (3'-UTR) of this gene were investigated in 427 goats (Capra hircus) of six breeds. Using dual colour fluorescence in situ hybridisation, SLC11A1 was localised to goat chromosome 2. Single strand conformation polymorphism was used to screen for polymorphisms in SLC11A1 exons 2, 10 and 15. There was no variation among goat breeds in the sarcoma homology 3 (SH3) binding motif, the protein kinase C phosphorylation site or the two N-linked glycosylation sites. Exon 15 exhibited variability due to the presence of two polymorphic microsatellites. Genotyping of the upstream guanine-thymine repeat (GTn) at 3'-UTR revealed eight alleles (GT11, GT12, GT14-GT19) in goats, whereas GT13 (present in cattle) was absent. Most goats carried the GT16 allele and no allele was found to be exclusive to only one breed. The coefficient of genetic differentiation value (G(ST)) was 0.084. This microsatellite appears to be an informative DNA marker for genetic linkage analysis in goats.

  8. Prognonstic impact of renin-angiotensin system blockade in localised upper-tract urothelial carcinoma

    Science.gov (United States)

    Tanaka, N; Miyajima, A; Kikuchi, E; Matsumoto, K; Hagiwara, M; Ide, H; Kosaka, T; Masuda, T; Nakamura, S; Oya, M

    2012-01-01

    Background: The potential role of the renin-angiotensin system (RAS) in the promotion of tumour growth has been investigated, and the administration of RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), may improve disease control in malignancy. We investigated the prognostic impact of RAS inhibitors by analysing data from patients with upper-tract urothelial carcinoma (UTUC). Methods: A total of 279 patients who underwent nephroureterectomy for localised UTUC (pTa-3N0M0) were identified at our three institutions. We retrospectively investigated the prognostic outcomes following nephroureterectomy in patients administered or not administered ACEIs or ARBs. Results: The median follow-up period was 3.4 years. RAS inhibitors were administered to 48 patients (17.2%). Multivariate analysis showed that the appearance of pathological T3, positive lymphovascular invasion, and no RAS inhibitor administration (P=0.027 HR=3.14) were independent risk factors for a decrease in subsequent metastasis-free survival. The 5-year metastasis-free survival rate was 93.0% in patients who administered RAS inhibitors, and 72.8% in their counterparts who did not (P=0.008). Conclusion: The absence of RAS inhibitor administration was an independent risk factor for subsequent tumour metastasis in patients with localised UTUC. We propose RAS inhibitors may be a potent choice as an effective treatment following nephroureterectomy. PMID:22187036

  9. Envelope and Wavelet Transform for Sound Localisation at Low Sampling Rates in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    O. M. Bouzid

    2012-01-01

    Full Text Available High sampling frequencies in acoustic wireless sensor network (AWSN are required to achieve precise sound localisation. But they are also mean analysis time and memory intensive (i.e., huge data to be processed and more memory space to be occupied which form a burden on the nodes limited resources. Decreasing sampling rates below Nyquist criterion in acoustic source localisation (ASL applications requires development of the existing time delay estimation techniques in order to overcome the challenge of low time resolution. This work proposes using envelope and wavelet transform to enhance the resolution of the received signals through the combination of different time-frequency contents. Enhanced signals are processed using cross-correlation in conjunction with a parabolic fit interpolation to calculate the time delay accurately. Experimental results show that using this technique, estimation accuracy was improved by almost a factor of 5 in the case of using 4.8 kHz sampling rate. Such a conclusion is useful for developing precise ASL without the need of any excessive sensor resources, particularly for structural health monitoring applications.

  10. Eimeria tenella microneme protein EtMIC3: identification, localisation and role in host cell infection.

    Science.gov (United States)

    Labbé, M; de Venevelles, P; Girard-Misguich, F; Bourdieu, C; Guillaume, A; Péry, P

    2005-03-01

    The gene coding for Eimeria tenella protein EtMIC3 was cloned by screening a sporozoite cDNA library with two independent monoclonal antibodies raised against the oocyst stage. The deduced sequence of EtMIC3 is 988 amino acids long. The protein presents seven repeats in tandem, with four highly conserved internal repeats and three more divergent external repeats. Each repeat is characterised by a tyrosine kinase phosphorylation site, WRCY, and a reminiscent motif of the thrombospondin1 (TSP1)-type I domain, CXXXCG. The protein EtMIC3 is localised at the apex of free parasite stages. It is not detected in the early intracellular parasite stage but is synthesised in mature schizonts. Secretion of the protein is induced when sporozoites are incubated in complete medium at 41 degrees C. Strangely enough, the two independent mAb that allow cloning of EtMIC3 interfere with parasitic growth in different ways. One is able to inhibit parasite invasion whereas the other inhibits development. Expression and localisation of the protein EtMIC3 are consistent with a protein involved in the invasion process as is expected for a microneme protein.

  11. Chemical shift imaging and localised magnetic resonance spectroscopy in full-term asphyxiated neonates

    Energy Technology Data Exchange (ETDEWEB)

    Brissaud, Olivier [Children' s Hospital, Paediatric Intensive Care Unit, Bordeaux (France); Chateil, Jean-Francois; Bordessoules, Martine; Brun, Muriel [Children' s Hospital, Radiology Unit, Bordeaux (France)

    2005-10-01

    Diagnosis of brain lesions after birth anoxia-ischemia is essential for appropriate management. Clinical evaluation is not sufficient. MRI has been proven to provide useful information. To compare abnormalities observed with MRI, including diffusion-weighted imaging (DWI), localised magnetic resonance spectroscopy (MRS) and chemical shift imaging (CSI) and correlate these findings with the clinical outcome. Fourteen full-term neonates with birth asphyxia were studied. MRI, MRS and CSI were performed within the first 4 days of life. Lesions observed with DWI were correlated with outcome, but the apparent diffusion coefficient (ADC) did improve diagnostic confidence. The mean value of Lac/Cr for the neonates with a favourable outcome was statically lower than for those who died (0.22 vs 1.04; P = 0.01). The same results were observed for the Lac/NAA ratio (0.21 vs 1.23; P = 0.01). Data obtained with localised MRS and CSI were correlated for the ratio N-acetyl-aspartate/choline, but not for the other metabolites. No correlation was found between the ADC values and the metabolite ratios. Combination of these techniques could be helpful in our understanding of the physiopathological events occurring in neonates with asphyxia. (orig.)

  12. Functional MRI of the brain: localisation of eloquent cortex in focal brain lesion therapy

    Energy Technology Data Exchange (ETDEWEB)

    Dymarkowski, S.; Sunaert, S.; Oostende, S. van; Hecke, P. van; Wilms, G.; Demaerel, P.; Marchal, G. [Department of Radiology, University Hospitals, Leuven (Belgium); Nuttin, B.; Plets, C. [Department of Neurosurgery, University Hospitals, Leuven (Belgium)

    1998-12-01

    The aim of this study was to assess the feasibility of functional MRI (fMRI) in a clinical environment on a large patient group, and to evaluate the pretherapeutic value of localisation of eloquent cortex. Forty patients with focal brain lesions of different origin were studied using fMRI. Functional information was obtained using motor, somatosensory, auditory and phonological stimuli depending on the localisation of the lesions. To obtain information about the spatial accuracy of fMRI, the results were compared with postoperative electrocortical stimulation. Two patients with secondary trigeminal neuralgia were scanned using a motor protocol and were implanted with an extradural plate electrode. Imaging was successful in 40 of 42 patients (including the 2 with trigeminal neuralgia). These patients were analysed for strength of activation, the relation of the lesion to activation sites and the presence of mass effect. The correlation between these data and surgical findings provided significant additional clinical information. Functional MRI can be accurately performed in patients with focal brain lesions using a dedicated approach. Functional MRI offers important clinical information as a contribution to a decrease in posttherapeutic morbidity. The accuracy of the technique can be confirmed by other modalities, including invasive cortical electrostimulation. (orig.) With 7 figs., 2 tabs., 25 refs.

  13. Modelling property changes in graphite irradiated at changing irradiation temperature

    CSIR Research Space (South Africa)

    Kok, S

    2011-01-01

    Full Text Available A new method is proposed to predict the irradiation induced property changes in nuclear; graphite, including the effect of a change in irradiation temperature. The currently used method; to account for changes in irradiation temperature, the scaled...

  14. Fukunaga-Koontz feature transformation for statistical structural damage detection and hierarchical neuro-fuzzy damage localisation

    Science.gov (United States)

    Hoell, Simon; Omenzetter, Piotr

    2017-07-01

    Considering jointly damage sensitive features (DSFs) of signals recorded by multiple sensors, applying advanced transformations to these DSFs and assessing systematically their contribution to damage detectability and localisation can significantly enhance the performance of structural health monitoring systems. This philosophy is explored here for partial autocorrelation coefficients (PACCs) of acceleration responses. They are interrogated with the help of the linear discriminant analysis based on the Fukunaga-Koontz transformation using datasets of the healthy and selected reference damage states. Then, a simple but efficient fast forward selection procedure is applied to rank the DSF components with respect to statistical distance measures specialised for either damage detection or localisation. For the damage detection task, the optimal feature subsets are identified based on the statistical hypothesis testing. For damage localisation, a hierarchical neuro-fuzzy tool is developed that uses the DSF ranking to establish its own optimal architecture. The proposed approaches are evaluated experimentally on data from non-destructively simulated damage in a laboratory scale wind turbine blade. The results support our claim of being able to enhance damage detectability and localisation performance by transforming and optimally selecting DSFs. It is demonstrated that the optimally selected PACCs from multiple sensors or their Fukunaga-Koontz transformed versions can not only improve the detectability of damage via statistical hypothesis testing but also increase the accuracy of damage localisation when used as inputs into a hierarchical neuro-fuzzy network. Furthermore, the computational effort of employing these advanced soft computing models for damage localisation can be significantly reduced by using transformed DSFs.

  15. The role of meiotic cohesin REC8 in chromosome segregation in {gamma} irradiation-induced endopolyploid tumour cells

    Energy Technology Data Exchange (ETDEWEB)

    Erenpreisa, Jekaterina [Latvian Biomedicine Research and Study Centre, Riga, LV-1067 (Latvia); Cragg, Mark S. [Tenovus Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton SO16 6YD (United Kingdom); Salmina, Kristine [Latvian Biomedicine Research and Study Centre, Riga, LV-1067 (Latvia); Hausmann, Michael [Kirchhoff Inst. fuer Physik, Univ. of Heidelberg, D-69120 Heidelberg (Germany); Scherthan, Harry, E-mail: scherth@web.de [Inst. fuer Radiobiologie der Bundeswehr in Verbindung mit der Univ. Ulm, D-80937 Munich (Germany); MPI for Molec. Genetics, 14195 Berlin (Germany)

    2009-09-10

    Escape from mitotic catastrophe and generation of endopolyploid tumour cells (ETCs) represents a potential survival strategy of tumour cells in response to genotoxic treatments. ETCs that resume the mitotic cell cycle have reduced ploidy and are often resistant to these treatments. In search for a mechanism for genome reduction, we previously observed that ETCs express meiotic proteins among which REC8 (a meiotic cohesin component) is of particular interest, since it favours reductional cell division in meiosis. In the present investigation, we induced endopolyploidy in p53-dysfunctional human tumour cell lines (Namalwa, WI-L2-NS, HeLa) by gamma irradiation, and analysed the sub-cellular localisation of REC8 in the resulting ETCs. We observed by RT-PCR and Western blot that REC8 is constitutively expressed in these tumour cells, along with SGOL1 and SGOL2, and that REC8 becomes modified after irradiation. REC8 localised to paired sister centromeres in ETCs, the former co-segregating to opposite poles. Furthermore, REC8 localised to the centrosome of interphase ETCs and to the astral poles in anaphase cells where it colocalised with the microtubule-associated protein NuMA. Altogether, our observations indicate that radiation-induced ETCs express features of meiotic cell divisions and that these may facilitate chromosome segregation and genome reduction.

  16. Localisation endobronchique d'une leucémie aiguë lymphoblastique de phénotype T

    Science.gov (United States)

    Sajiai, Hafsa; Fikal, Siham; Serhane, Hind; Aitbatahar, Salma; Amro, Lamyae; Yazidi, Abdelhaq Alaoui

    2015-01-01

    La localisation endobronchique des leucémies aigues lymphoblastiques est exceptionnelle, de rares cas ont été rapportés dans la littérature. Nous rapportons le cas d'une localisation endobronchique d'une leucémie aigue lymphoblastique de phénotype T révélée par une pleurésie purulente et confirmée par biopsie bronchique. Une chimiothérapie a été démarrée avec bonne évolution. PMID:26401199

  17. Organization of crop and animal production in dairy farms localised in three chosen regions of lubelskie voivodeship

    Directory of Open Access Journals (Sweden)

    Jolanta Bojarszczuk

    2010-01-01

    Full Text Available The evaluation of organization of crop and animal production in dairy farms localised in three regions in Lubelskie voivodeship was presented in the paper. The data source was questionnaire research. The study was trained in 145 farms. The provided analysis showed that cereals had significantly share in pattern system in tested farms. Researched farms are differentiated of occupied differentiation of cropping pattern and density livestock between farms localised in different regions of Lubelskie voivodeship caused different level of intensity of organization animal and crops production. The differentiation of indicators was especially significant between farms in Krasnystaw and Ryki.

  18. Irradiation Creep in Graphite

    Energy Technology Data Exchange (ETDEWEB)

    Ubic, Rick; Butt, Darryl; Windes, William

    2014-03-13

    An understanding of the underlying mechanisms of irradiation creep in graphite material is required to correctly interpret experimental data, explain micromechanical modeling results, and predict whole-core behavior. This project will focus on experimental microscopic data to demonstrate the mechanism of irradiation creep. High-resolution transmission electron microscopy should be able to image both the dislocations in graphite and the irradiation-induced interstitial clusters that pin those dislocations. The team will first prepare and characterize nanoscale samples of virgin nuclear graphite in a transmission electron microscope. Additional samples will be irradiated to varying degrees at the Advanced Test Reactor (ATR) facility and similarly characterized. Researchers will record microstructures and crystal defects and suggest a mechanism for irradiation creep based on the results. In addition, the purchase of a tensile holder for a transmission electron microscope will allow, for the first time, in situ observation of creep behavior on the microstructure and crystallographic defects.

  19. Modelling of accidental released toxic gases for emergency responders in Austria, Kosovo and Bulgaria.

    Science.gov (United States)

    Stenzel, Sirma; Baumann-Stanzer, Kathrin; Gashi, Salih; Thaci, Bashkim; Batchvarova, Ekaterina; Spassova, Tatiana

    2010-05-01

    In the case of accidental release of hazardous gases in the atmosphere, the emergency responders need a reliable and fast tool to assess the possible consequences and apply the optimal countermeasures. A number of models for the prediction and simulation of hazard areas affected by accidental releases of toxic gases are available worldwide. Modelling accidental releases may be required for a variety of reasons: for analyzing different accidental toxic release scenarios ("worst-case scenarios"), for preparing emergency response plans and optimal countermeasures as well as for real-time risk assessment and management (e.g. in the frame of the SEVESO directive). Depending on the demand and the particular purposes, the choice of the appropriate model is up to the authorities. The one year project was funded by the Austrian Science and research liaison Office (ASO, www.aso.zsi.at) as a part of the program: Research Cooperation and Networking between Austria, the public higher education institutions in Kosovo and South Eastern Europe. The project was conducted by the Central Institute for Meteorology and Geodynamics (ZAMG, http://www.zamg.ac.at) in cooperation with the University of Prishtina (Kosovo, www.uni-pr.edu and the National Institute of meteorology and Hydrology (NIHM Bulgaria, www.meteo.bg). One of the main purposes of the project was to provide the both partners with basic knowledge in modelling with accidental release of toxic gases, based on the practical experience of the meteorologists from the ZAMG in the area. This knowledge can be used as scientific response to society driven current or upcoming problems especially in Kosovo. The activities involved know-how transfer on European standards and practice among the project partners, as well as joint efforts to adapt and disseminate the scientific methods and results in Kosovo. Within the project, the partners from Kosovo and Bulgaria were introduced to the atmospheric dispersion model (ALOHA - Areal

  20. Determinants of suicide and accidental or violent death in the Australian HIV Observational Database.

    Directory of Open Access Journals (Sweden)

    Hamish McManus

    Full Text Available BACKGROUND: Rates of suicide and accidental or violent death remain high in HIV-positive populations despite significantly improved prognosis since the introduction of cART. METHODS: We conducted a nested case-control study of suicide and accidental or violent death in the Australian HIV Observational Database (AHOD between January 1999 and March 2012. For each case, 2 controls were matched by clinic, age, sex, mode of exposure and HIV-positive date to adjust for potential confounding by these covariates. Risk of suicide and accidental or violent death was estimated using conditional logistic regression. RESULTS: We included 27 cases (17 suicide and 10 violent/accidental death and 54 controls. All cases were men who have sex with men (MSM or MSM/ injecting drug use (IDU mode of exposure. Increased risk was associated with unemployment (Odds Ratio (OR 5.86, 95% CI: 1.69-20.37, living alone (OR 3.26, 95% CI: 1.06-10.07, suicidal ideation (OR 6.55, 95% CI: 1.70-25.21, and >2 psychiatric/cognitive risk factors (OR 4.99, 95% CI: 1.17-30.65. CD4 cell count of >500 cells/µL (OR 0.25, 95% CI: 0.07-0.87 and HIV-positive date ≥1990 (1990-1999 (OR 0.31, 95% CI: 0.11-0.89, post-2000 (OR 0.08, 95% CI: 0.01-0.84 were associated with decreased risk. CD4 cell count ≥500 cells/µL remained a significant predictor of reduced risk (OR 0.15, 95% CI: 0.03-0.70 in a multivariate model adjusted for employment status, accommodation status and HIV-positive date. CONCLUSIONS: After adjustment for psychosocial factors, the immunological status of HIV-positive patients contributed to the risk of suicide and accidental or violent death. The number of psychiatric/cognitive diagnoses contributed to the level of risk but many psychosocial factors were not individually significant. These findings indicate a complex interplay of factors associated with risk of suicide and accidental or violent death.

  1. Evaluation of specimen preparation techniques for micro-PIXE localisation of elements in hyperaccumulating plants

    Energy Technology Data Exchange (ETDEWEB)

    Kachenko, Anthony G. [Faculty of Agriculture, Food and Natural Resources, University of Sydney, New South Wales 2006 (Australia)], E-mail: a.kachenko@usyd.edu.au; Siegele, Rainer; Bhatia, Naveen P. [Institute for Environmental Research, Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales 2234 (Australia); Singh, Balwant [Faculty of Agriculture, Food and Natural Resources, University of Sydney, New South Wales 2006 (Australia); Ionescu, Mihail [Institute for Environmental Research, Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales 2234 (Australia)

    2008-04-15

    Hybanthus floribundus subsp. floribundus, a rare Australian Ni-hyperaccumulating shrub and Pityrogramma calomelanos var. austroamericana, an Australian naturalized As-hyperaccumulating fern are promising species for use in phytoremediation of contaminated sites. Micro-proton-induced X-ray emission ({mu}-PIXE) spectroscopy was used to map the elemental distribution of the accumulated metal(loid)s, Ca and K in leaf or pinnule tissues of the two plant species. Samples were prepared by two contrasting specimen preparation techniques: freeze-substitution in tetrahydrofuran (THF) and freeze-drying. The specimens were analysed to compare the suitability of each technique in preserving (i) the spatial elemental distribution and (ii) the tissue structure of the specimens. Further, the {mu}-PIXE results were compared with concentration of elements in the bulk tissue obtained by ICP-AES analysis. In H. floribundus subsp. floribundus, {mu}-PIXE analysis revealed Ni, Ca and K concentrations in freeze-dried leaf tissues were at par with bulk tissue concentrations. Elemental distribution maps illustrated that Ni was preferentially localised in the adaxial epidermal tissues (1% DW) and least concentration was found in spongy mesophyll tissues (0.53% DW). Conversely, elemental distribution maps of THF freeze-substituted tissues indicated significantly lower Ni, Ca and K concentrations than freeze-dried specimens and bulk tissue concentrations. Moreover, Ni concentrations were uniform across the whole specimen and no localisation was observed. In P. calomelanos var. austroamericana freeze-dried pinnule tissues, {mu}-PIXE revealed statistically similar As, Ca and K concentrations as compared to bulk tissue concentrations. Elemental distribution maps showed that As localisation was relatively uniform across the whole specimen. Once again, THF freeze-substituted tissues revealed a significant loss of As compared to freeze-dried specimens and the concentrations obtained by bulk tissue

  2. Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation.

    Directory of Open Access Journals (Sweden)

    Maria Vittoria Barone

    Full Text Available BACKGROUND: Celiac Disease (CD is both a frequent disease (1:100 and an interesting model of a disease induced by food. It consists in an immunogenic reaction to wheat gluten and glutenins that has been found to arise in a specific genetic background; however, this reaction is still only partially understood. Activation of innate immunity by gliadin peptides is an important component of the early events of the disease. In particular the so-called "toxic" A-gliadin peptide P31-43 induces several pleiotropic effects including Epidermal Growth Factor Receptor (EGFR-dependent actin remodelling and proliferation in cultured cell lines and in enterocytes from CD patients. These effects are mediated by delayed EGFR degradation and prolonged EGFR activation in endocytic vesicles. In the present study we investigated the effects of gliadin peptides on the trafficking and maturation of endocytic vesicles. METHODS/PRINCIPAL FINDINGS: Both P31-43 and the control P57-68 peptide labelled with fluorochromes were found to enter CaCo-2 cells and interact with the endocytic compartment in pulse and chase, time-lapse, experiments. P31-43 was localised to vesicles carrying early endocytic markers at time points when P57-68-carrying vesicles mature into late endosomes. In time-lapse experiments the trafficking of P31-43-labelled vesicles was delayed, regardless of the cargo they were carrying. Furthermore in celiac enterocytes, from cultured duodenal biopsies, P31-43 trafficking is delayed in early endocytic vesicles. A sequence similarity search revealed that P31-43 is strikingly similar to Hrs, a key molecule regulating endocytic maturation. A-gliadin peptide P31-43 interfered with Hrs correct localisation to early endosomes as revealed by western blot and immunofluorescence microscopy. CONCLUSIONS: P31-43 and P57-68 enter cells by endocytosis. Only P31-43 localises at the endocytic membranes and delays vesicle trafficking by interfering with Hrs

  3. Evaluation of specimen preparation techniques for micro-PIXE localisation of elements in hyperaccumulating plants

    Science.gov (United States)

    Kachenko, Anthony G.; Siegele, Rainer; Bhatia, Naveen P.; Singh, Balwant; Ionescu, Mihail

    2008-04-01

    Hybanthus floribundus subsp. floribundus, a rare Australian Ni-hyperaccumulating shrub and Pityrogramma calomelanos var. austroamericana, an Australian naturalized As-hyperaccumulating fern are promising species for use in phytoremediation of contaminated sites. Micro-proton-induced X-ray emission (μ-PIXE) spectroscopy was used to map the elemental distribution of the accumulated metal(loid)s, Ca and K in leaf or pinnule tissues of the two plant species. Samples were prepared by two contrasting specimen preparation techniques: freeze-substitution in tetrahydrofuran (THF) and freeze-drying. The specimens were analysed to compare the suitability of each technique in preserving (i) the spatial elemental distribution and (ii) the tissue structure of the specimens. Further, the μ-PIXE results were compared with concentration of elements in the bulk tissue obtained by ICP-AES analysis. In H. floribundus subsp. floribundus, μ-PIXE analysis revealed Ni, Ca and K concentrations in freeze-dried leaf tissues were at par with bulk tissue concentrations. Elemental distribution maps illustrated that Ni was preferentially localised in the adaxial epidermal tissues (1% DW) and least concentration was found in spongy mesophyll tissues (0.53% DW). Conversely, elemental distribution maps of THF freeze-substituted tissues indicated significantly lower Ni, Ca and K concentrations than freeze-dried specimens and bulk tissue concentrations. Moreover, Ni concentrations were uniform across the whole specimen and no localisation was observed. In P. calomelanos var. austroamericana freeze-dried pinnule tissues, μ-PIXE revealed statistically similar As, Ca and K concentrations as compared to bulk tissue concentrations. Elemental distribution maps showed that As localisation was relatively uniform across the whole specimen. Once again, THF freeze-substituted tissues revealed a significant loss of As compared to freeze-dried specimens and the concentrations obtained by bulk tissue analysis

  4. Swift heavy ion irradiation effects in {alpha} poly(vinylidene fluoride); Etude des effets induits par les ions lourds energetiques dans le poly(fluorure de vinylidene)

    Energy Technology Data Exchange (ETDEWEB)

    Le Bouedec, A

    1999-11-29

    The goal of this study is to characteristic and to localised defects created in {alpha} Poly (vinylidene fluoride) after swift heavy ion irradiations. PVDF films are irradiated with several Swift Heavy Ions (SHI), in the electronic stopping power (dE/dx){sub e}, in order to study the influence of irradiation parameters (absorbed dose, ion). These irradiated films are studied by different analysis techniques such as FTIR, ESR (X and Q band) spectroscopies and DSC. The crystalline level of PVDF is about 50% and we follow it destruction and amorphization as the absorbed dose increase by DSC and FTIR studies. The variation of the various FTIR bands allow us to observe the unsaturations induced by SHI radiations. Two sets of defects are observed: those which yield is sensitive to an increase of (dE/dx){sub e} and those that are not. A spatial distribution of the various defects within the talent track is provided and defects that are difficult to create are the closest of the ion path. The different kind of radicals created after irradiations are studied by ESR spectroscopy. Alkyl, peroxy and polyenyl radicals are detected after SHI radiations like after electron or {gamma} irradiations. Their yield of creation is independent of (dE/dx){sub e} and their localised in the crystalline zone or/and at the interfacial zone between crystalline and amorphous one. An other kind of radicals is created only after SHI radiations that are specific of the SHI-polymer interaction. We observe that these radicals are localised on a carbon cluster, in the core of the latent track for low doses and highly sensitive at the (dE/dx){sub e} of the ion. (author)

  5. Multifocal Inflammatory Leukoencephalopathy Induced by Accidental Consumption of Levamisole: A Case Report

    Directory of Open Access Journals (Sweden)

    Ali Ghanbari

    2012-01-01

    Full Text Available Levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. The present study aimed to show accidental consumption of levamisole alone induced multifocalinflammatory leukoencephalopathy. A 53-year-old male was admitted to the Neurology Department of Farabi Hospital(Kermanshah, Iran with walking inability and recognition disorder. Following clinical examinations, the patient diagnosed as multifocal inflammatory leukoencephalopathy following levamisole consumption.The patient was treated with intravenous methylprednisolone followed by prednisolone. The magnetic resonance imaging (MRI was done 1 month later and did not show a reduction or remission in the lesions. History of the patient showed that he had accidentally consumed levamisole 8 months ago. It seems that the consumption of levamisole can induce multifocal inflammatory leukoencephalopathy and delayed treatment of the patient with corticosteroid cannot diminish the neurotoxicity of levamisole. In addition, the cytotoxic dose of levamisole induces irreversible multifocal inflammatory leukoencephalopathy.

  6. Multifocal inflammatory leukoencephalopathy induced by accidental consumption of levamisole: A case report

    Science.gov (United States)

    Sariaslani, Payam; Ghanbari, Parvin

    2012-01-01

    Levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. The present study aimed to show accidental consumption of levamisole alone induced multifocal inflammatory leukoencephalopathy. A 53-year-old male was admitted to the Neurology Department of Farabi Hospital (Kermanshah, Iran) with walking inability and recognition disorder. Following clinical examinations, the patient diagnosed as multifocal inflammatory leukoencephalopathy following levamisole consumption.The patient was treated with intravenous methylprednisolone followed by prednisolone. The magnetic resonance imaging (MRI) was done 1 month later and did not show a reduction or remission in the lesions. History of the patient showed that he had accidentally consumed levamisole 8 months ago. It seems that the consumption of levamisole can induce multifocal inflammatory leukoencephalopathy and delayed treatment of the patient with corticosteroid cannot diminish the neurotoxicity of levamisole. In addition, the cytotoxic dose of levamisole induces irreversible multifocal inflammatory leukoencephalopathy. PMID:24250864

  7. Photonic crystal surface-emitting lasers enabled by an accidental Dirac point

    Science.gov (United States)

    Chua, Song Liang; Lu, Ling; Soljacic, Marin

    2014-12-02

    A photonic-crystal surface-emitting laser (PCSEL) includes a gain medium electromagnetically coupled to a photonic crystal whose energy band structure exhibits a Dirac cone of linear dispersion at the center of the photonic crystal's Brillouin zone. This Dirac cone's vertex is called a Dirac point; because it is at the Brillouin zone center, it is called an accidental Dirac point. Tuning the photonic crystal's band structure (e.g., by changing the photonic crystal's dimensions or refractive index) to exhibit an accidental Dirac point increases the photonic crystal's mode spacing by orders of magnitudes and reduces or eliminates the photonic crystal's distributed in-plane feedback. Thus, the photonic crystal can act as a resonator that supports single-mode output from the PCSEL over a larger area than is possible with conventional PCSELs, which have quadratic band edge dispersion. Because output power generally scales with output area, this increase in output area results in higher possible output powers.

  8. Accidental Displacement of Third Molar into the Sublingual Space: a Case Report

    Directory of Open Access Journals (Sweden)

    Rubens Jorge

    2014-10-01

    Full Text Available Background: Successful extraction of third molars depends on preoperative diagnosis and planning. Gold standard preoperative examinations are performed through computed tomography, decreasing risks and avoiding potential accidents. The present report highlights the value of preoperative examinations in face of accidentally displaced third molars. Methods: An 18-years-old female patient underwent a third mandibular molar extraction with a general dentist. Accidentally, the mandibular left third molar was displaced into the sublingual space, making necessary a second surgical step. The surgery was interrupted and the patient was referred to an expert in maxillofacial surgery. Results: After 21 days awaiting an asymptomatic health status, the second surgical step was successfully performed using multislice computed tomography as preoperative imaging guide. Conclusions: The present case report highlights the clinical usefulness of imaging planning and informed consents in face of legal and ethic potential complaints.

  9. Marine oil spill risk mapping for accidental pollution and its application in a coastal city.

    Science.gov (United States)

    Lan, Dongdong; Liang, Bin; Bao, Chenguang; Ma, Minghui; Xu, Yan; Yu, Chunyan

    2015-07-15

    Accidental marine oil spill pollution can result in severe environmental, ecological, economic and other consequences. This paper discussed the model of Marine Oil Spill Risk Mapping (MOSRM), which was constructed as follows: (1) proposing a marine oil spill risk system based on the typical marine oil spill pollution accidents and prevailing risk theories; (2) identifying suitable indexes that are supported by quantitative sub-indexes; (3) constructing the risk measuring models according to the actual interactions between the factors in the risk system; and (4) assessing marine oil spill risk on coastal city scale with GIS to map the overall risk. The case study of accidental marine oil spill pollution in the coastal area of Dalian, China was used to demonstrate the effectiveness of the model. The coastal areas of Dalian were divided into three zones with risk degrees of high, medium, and low. And detailed countermeasures were proposed for specific risk zones.

  10. [The prevalence of accidental poisoning in a hospital pediatric unit of Latium].

    Science.gov (United States)

    Faraoni, F; Protano, C; Bini, V; Lizzi, R

    2006-01-01

    The aim of this study was to investigate the trend of accidental poisoning among children, over a period of fifteen years, from 1990 to 2004, in the pediatric wards of a hospital in Latium (Italy). The prevalence of childhood poisoning was calculated based on the medical records of the pediatric unit of the hospital. The derived data was divided into different categories according to age, gender and types of poisoning. The results of this study show a decrease in accidental pediatric poisoning; according to the literature the frequency of poisoning was higher in males, under the age of 2 years, than females. Trends show an increase in pharmaceutical poisonings. The present study underlines the need for continuous information on prevention and educational programs organized by the Institutions, territorial sanitary services and GP with the aim of increasing the awareness of parents regarding the risk factors of poisoning.

  11. Accidental versus operational oil spills from shipping in the Baltic Sea: risk governance and management strategies.

    Science.gov (United States)

    Hassler, Björn

    2011-03-01

    Marine governance of oil transportation is complex. Due to difficulties in effectively monitoring procedures on vessels en voyage, incentives to save costs by not following established regulations on issues such as cleaning of tanks, crew size, and safe navigation may be substantial. The issue of problem structure is placed in focus, that is, to what degree the specific characteristics and complexity of intentional versus accidental oil spill risks affect institutional responses. It is shown that whereas the risk of accidental oil spills primarily has been met by technical requirements on the vessels in combination with Port State control, attempts have been made to curb intentional pollution by for example increased surveillance and smart governance mechanisms such as the No-Special-Fee system. It is suggested that environmental safety could be improved by increased use of smart governance mechanisms tightly adapted to key actors' incentives to alter behavior in preferable directions.

  12. A Precise Analytic Delayed Coincidence Efficiency and Accidental Coincidence Rate Calculation

    CERN Document Server

    Yu, Jingyi; Chen, Shaomin

    2013-01-01

    In a delayed coincidence experiment, for example, the recent reactor neutrino oscillation experiments, a precise analytic determination of the delayed coincidence signal efficiency and the accidental coincidence background rate is important for the high accuracy measurement of the oscillation parameters and to understand systematic uncertainties associated with fluctuations in muon rate and random background rate. In this work, a data model is proposed to describe the full time sequence of all possible events on the live time axis. The acceptance of delayed coincidence signals, the rate of accidental backgrounds and other coincidence possibilities are calculated by assuming that all of the `net muons' are uniformly distributed on the live time axis. The intrinsic relative uncertainties in the event rates are at the $10^{-5}$ level for all combinations. The model and predictions are verified with a high statistics Monte Carlo study with a set of realistic parameters.

  13. Multifocal inflammatory leukoencephalopathy induced by accidental consumption of levamisole: A case report.

    Science.gov (United States)

    Sariaslani, Payam; Ghanbari, Ali; Ghanbari, Parvin

    2012-01-01

    Levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. The present study aimed to show accidental consumption of levamisole alone induced multifocal inflammatory leukoencephalopathy. A 53-year-old male was admitted to the Neurology Department of Farabi Hospital (Kermanshah, Iran) with walking inability and recognition disorder. Following clinical examinations, the patient diagnosed as multifocal inflammatory leukoencephalopathy following levamisole consumption.The patient was treated with intravenous methylprednisolone followed by prednisolone. The magnetic resonance imaging (MRI) was done 1 month later and did not show a reduction or remission in the lesions. History of the patient showed that he had accidentally consumed levamisole 8 months ago. It seems that the consumption of levamisole can induce multifocal inflammatory leukoencephalopathy and delayed treatment of the patient with corticosteroid cannot diminish the neurotoxicity of levamisole. In addition, the cytotoxic dose of levamisole induces irreversible multifocal inflammatory leukoencephalopathy.

  14. Localisation of an Unknown Number of Land Mines Using a Network of Vapour Detectors

    Directory of Open Access Journals (Sweden)

    Hiba Haj Chhadé

    2014-11-01

    Full Text Available We consider the problem of localising an unknown number of land mines usingconcentration information provided by a wireless sensor network. A number of vapoursensors/detectors, deployed in the region of interest, are able to detect the concentrationof the explosive vapours, emanating from buried land mines. The collected data iscommunicated to a fusion centre. Using a model for the transport of the explosive chemicalsin the air, we determine the unknown number of sources using a Principal ComponentAnalysis (PCA-based technique. We also formulate the inverse problem of determiningthe positions and emission rates of the land mines using concentration measurementsprovided by the wireless sensor network. We present a solution for this problem basedon a probabilistic Bayesian technique using a Markov chain Monte Carlo sampling scheme,and we compare it to the least squares optimisation approach. Experiments conducted onsimulated data show the effectiveness of the proposed approach.

  15. Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands

    DEFF Research Database (Denmark)

    Fahrenkrug, Jan; Hannibal, Jens

    2011-01-01

    PACAP (pituitary adenylate cyclase activating polypeptide) is widely distributed neuropeptide acting via three subtypes of receptors, PAC(1), VPAC(1) and VPAC(2). Here we examined the localisation and nature of PACAP-immunoreactive nerves in the rat thyroid and parathyroid glands and defined...... the distribution of PAC(1), VPAC(1) and VPAC(2) receptor mRNA's. In the parathyroid gland a large number of nerve fibres displaying PACAP-immunoreactivity were distributed beneath the capsule, around blood vessels and close to glandular cells. Most of the PACAP-nerves were sensory, since they co-stored CGRP...... (calcitonin-gene-related peptide) and were sensitive to capsaicin-treatment. mRNA's for PAC(1) and VPAC(2) receptors occurred in the parathyroid gland, mainly located in the glandular cells. In the thyroid gland PACAP-immunoreactive nerve fibres were associated with blood vessels, thyroid follicles...

  16. Gap eigenmode of radially localised helicon waves in a periodic structure

    CERN Document Server

    Chang, Lei; Hole, Matthew J

    2012-01-01

    An ElectroMagnetic Solver (EMS) [Chen et al., Phys. Plasmas, 13, 123507 (2006)] is employed to model a spectral gap and a gap eigenmode in a periodic structure in the whistler frequency range. A Radially Localised Helicon (RLH) mode [Breizman and Arefiev, Phys. Rev. Lett, 84, 3863 (2000)] is considered. We demonstrate that the computed gap frequency and gap width agree well with a theoretical analysis, and find a discrete eigenmode inside the gap by introducing a defect to the system's periodicity. The axial wavelength of the gap eigenmode is close to twice the system's periodicity, which is consistent with Bragg's law. Such an eigenmode could be excited by energetic electrons, similar to the excitation of Toroidal Alfv\\'{e}n Eigenmodes (TAE) by energetic ions in tokamaks.

  17. OCTOPUS, a polarly localised membrane-associated protein, regulates phloem differentiation entry in Arabidopsis thaliana.

    Science.gov (United States)

    Truernit, Elisabeth; Bauby, Hélène; Belcram, Katia; Barthélémy, Julien; Palauqui, Jean-Christophe

    2012-04-01

    Vascular development is embedded into the developmental context of plant organ differentiation and can be divided into the consecutive phases of vascular patterning and differentiation of specific vascular cell types (phloem and xylem). To date, only very few genetic determinants of phloem development are known. Here, we identify OCTOPUS (OPS) as a potentiator of phloem differentiation. OPS is a polarly localised membrane-associated protein that is initially expressed in provascular cells, and upon vascular cell type specification becomes restricted to the phloem cell lineage. OPS mutants display a reduction of cotyledon vascular pattern complexity and discontinuous phloem differentiation, whereas OPS overexpressers show accelerated progress of cotyledon vascular patterning and phloem differentiation. We propose that OPS participates in vascular differentiation by interpreting longitudinal signals that lead to the transformation of vascular initials into differentiating protophloem cells.

  18. Vitronectin (serum spreading factor): its localisation in normal and fibrotic tissue.

    Science.gov (United States)

    Reilly, J T; Nash, J R

    1988-12-01

    The distribution of vitronectin and fibronectin in normal and fibrotic tissue was directly compared using indirect immunofluorescence. Both glycoproteins were ubiquitiously localised to loose connective tissue. Vitronectin, unlike fibronectin, was not detected in basement membranes, in normal renal glomeruli, or around smooth muscle cells of both musculares mucosae and propria of the gastrointestinal tract. The presence of vitronectin could not be shown in washed permeabilised platelets. Vitronectin was very much increased in reactive and fibrotic tissue, as was fibronectin. This was observed in lymph nodes affected by both nodular sclerosing Hodgkin's disease and by metastatic carcinoma as well as in myelofibrotic bone marrow and sclerotic glomeruli. These findings suggest that vitronectin may have an important role in the processes of inflammation and repair.

  19. Lyapounov exponents of products of random matrices: weak disorder expansion. Application to localisation

    Energy Technology Data Exchange (ETDEWEB)

    Derrida, B.; Mecheri, K.; Pichard, J.L.

    1987-05-01

    We derive the weak disorder expansion of the Lyapounov exponents of a product of random matrices. The condition for this expansion to be valid is that in the limit of zero disorder, the matrix has all its eigenvalues with different moduli. As an example, we study the problem of localisation on strips in the limit of weak disorder. We show that our expansion agrees very well with numerical simulations in the region where the condition on the moduli is satisfied which corresponds to energies outside the conduction band. In that region, we find a limiting density of Lyapounov exponents when the strip width goes to infinity. Inside the band, our expansion cannot be valid unless one adds an imaginary part to the energy.

  20. Analysis of band-anticrossing model in GaNAs near localised states

    Energy Technology Data Exchange (ETDEWEB)

    Seifikar, Masoud; O' Reilly, Eoin P.; Fahy, Stephen [Tyndall National Institute, Lee Maltings, Prospect Row, Cork (Ireland); Department of Physics, University College Cork, Cork (Ireland)

    2011-05-15

    Replacing As by N in GaNAs leads to a strong perturbation of the conduction band structure, generally described using the band-anticrossing (BAC) model. We have solved the single particle Hamiltonian for a very large supercell containing randomly placed nitrogen and have calculated the fractional {gamma} character, localisation factor and the density of states in the supercell. Comparison of these results with those calculated by the 2-level BAC model confirms the validity of the BAC model at energies away from N state energies but highlights the role of disorder at energies close to the N state energy. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  1. Radiation treatment planning for bladder cancer: a comparison of cystogram localisation with computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Rothwell, R.I.; Ash, D.V.; Jones, W.G. (Cookridge Hospital, Leeds (UK))

    1983-01-01

    A comparison has been made between the target volumes of radical radiotherapy treatment plans produced with the aid of marker cystograms, and target volumes derived from computed tomography (CT) scans in 60 patients with bladder cancer. This has demonstrated inadequacies of the cystograms due to the inability to delineate extravesical spread of tumour and, as many patients with bladder cancer had a significant residual urine, emptying the bladder by catheterisation may have given a false impression of the shape and size of the target volume. Analysis of the results showed that cystographic localisation resulted in serious underdosage of the tumour in 18% of patients and failure to include all the bladder in 37%. Conventionally produced target volumes showed potentially significant discrepancies in 85% of patients when compared with target volumes delineated by CT.

  2. Strain localisation during basin inversion in the North German basin and the Donbas Fold Belt

    Energy Technology Data Exchange (ETDEWEB)

    Maystrenko, Y.; Bayer, U. [GFZ Potsdam (Germany); Gajewski, D. [Hamburg Univ. (Germany). Inst. fuer Geophysik

    2007-09-13

    The DEKORP Basin'96 and the DOBREflection-200 lines provide two world wide exceptional examples of successfully performed deep seismic lines. This is especially true for the inversion of the two basins by representing probably two stages in the amount of shortening accompanied by strain localization causing decoupling of the sedimentary fill from the deeper crust within the North East German basin and the Donbas Fold Belt. High-velocity bodies are observed in the DEKORP Basin'96 and DOBREflection-2000 reflection seismic lines. These bodies may have been essential in localizing strain localisation by counteracting compressive forces and causing folding and finally failure and faulting of the deep crust. (orig.)

  3. Extremely narrow spectrum of GRB110920A: further evidence for localised, subphotospheric dissipation

    CERN Document Server

    Iyyani, S; Ahlgren, B; Burgess, J M; Larsson, J; Pe'er, A; Lundman, C; Axelsson, M; McGlynn, S

    2015-01-01

    Much evidence points towards that the photosphere in the relativistic outflow in GRBs plays an important role in shaping the observed MeV spectrum. However, it is unclear whether the spectrum is fully produced by the photosphere or whether a substantial part of the spectrum is added by processes far above the photosphere. Here we make a detailed study of the $\\gamma-$ray emission from single pulse GRB110920A which has a spectrum that becomes extremely narrow towards the end of the burst. We show that the emission can be interpreted as Comptonisation of thermal photons by cold electrons in an unmagnetised outflow at an optical depth of $\\tau \\sim 20$. The electrons receive their energy by a local dissipation occurring close to the saturation radius. The main spectral component of GRB110920A and its evolution is thus, in this interpretation, fully explained by the emission from the photosphere including localised dissipation at high optical depths.

  4. The fundamental role of localised vibrations in excitation dynamics in photosynthetic light-harvesting systems

    CERN Document Server

    Kolli, Avinash; Scholes, Gregory D; Olaya-Castro, Alexandra

    2012-01-01

    The importance of fast vibrations in enhancing and controlling energy transfer and conversion in biomolecules is an issue of current debate. In this article we show that coupling between localised high-frequency vibrations and electronic degrees of freedom is fundamental for efficient excitation transport in photosynthetic light-harvesting systems with high degree of disorder. We consider the cryptophyte antennae protein phycoerythrin 545 and discuss how the balance between electronic interactions and coupling to fast vibronic modes supports the biological function of these antennae by generating a non-cascaded transport that leads to a rapid, directed and wider spatial distribution of excitation energy across the complex. Furthermore, we illustrate signatures of vibronic influence in the beating of excitonic coherences and show that mechanisms supporting coherent evolution of excitons also assist coupling to selected modes that enhance energy transfer to preferential sites in the complex. We therefore argue ...

  5. Distinguishing Cause from Correlation in Tokamak Experiments to Trigger Edge Localised Plasma Instabilities

    CERN Document Server

    Webster, A J

    2014-01-01

    The generic question is considered: How can we determine the probability of an otherwise quasirandom event, having been triggered by an external influence? A specific problem is the quantification of the success of techniques to trigger, and hence control, edge-localised plasma instabilities (ELMs) in magnetically confined fusion (MCF) experiments. The development of such techniques is essential to ensure tolerable heat loads on components in large MCF fusion devices, and is necessary for their development into economically successful power plants. Bayesian probability theory is used to rigorously formulate the problem and to provide a formal solution. Accurate but pragmatic methods are developed to estimate triggering probabilities, and are illustrated with experimental data. These allow results from experiments to be quantitatively assessed, and rigorously quantified conclusions to be formed.

  6. Localisation of an unknown number of land mines using a network of vapour detectors.

    Science.gov (United States)

    Chhadé, Hiba Haj; Abdallah, Fahed; Mougharbel, Imad; Gning, Amadou; Julier, Simon; Mihaylova, Lyudmila

    2014-11-06

    We consider the problem of localising an unknown number of land mines using concentration information provided by a wireless sensor network. A number of vapour sensors/detectors, deployed in the region of interest, are able to detect the concentration of the explosive vapours, emanating from buried land mines. The collected data is communicated to a fusion centre. Using a model for the transport of the explosive chemicals in the air, we determine the unknown number of sources using a Principal Component Analysis (PCA)-based technique. We also formulate the inverse problem of determining the positions and emission rates of the land mines using concentration measurements provided by the wireless sensor network. We present a solution for this problem based on a probabilistic Bayesian technique using a Markov chain Monte Carlo sampling scheme, and we compare it to the least squares optimisation approach. Experiments conducted on simulated data show the effectiveness of the proposed approach.

  7. Localised strain sensing of dielectric elastomers in a stretchable soft-touch musical keyboard

    Science.gov (United States)

    Xu, Daniel; Tairych, Andreas; Anderson, Iain A.

    2015-04-01

    We present a new sensing method that can measure the strain at different locations in a dielectric elastomer. The method uses multiple sensing frequencies to target different regions of the same dielectric elastomer to simultaneously detect position and pressure using only a single pair of connections. The dielectric elastomer is modelled as an RC transmission line and its internal voltage and current distribution used to determine localised capacitance changes resulting from contact and pressure. This sensing method greatly simplifies high degree of freedom systems and does not require any modifications to the dielectric elastomer or sensing hardware. It is demonstrated on a multi-touch musical keyboard made from a single low cost carbon-based dielectric elastomer with 4 distinct musical tones mapped along a length of 0.1m. Loudness was controlled by the amount of pressure applied to each of these 4 positions.

  8. Localised $\\bf{AdS_5\\times S^5}$ Black Holes

    CERN Document Server

    Dias, Oscar J C; Way, Benson

    2016-01-01

    We numerically construct asymptotically global $\\mathrm{AdS}_5\\times \\mathrm{S}^5$ black holes that are localised on the $\\mathrm{S}^5$. These are solutions to type IIB supergravity with $\\mathrm S^8$ horizon topology that dominate the theory in the microcanonical ensemble at small energies. At higher energies, there is a first-order phase transition to $\\mathrm{AdS}_5$-Schwarzschild$\\times \\mathrm{S}^5$. By the AdS/CFT correspondence, this transition is dual to spontaneously breaking the $SO(6)$ R-symmetry of $\\mathcal N=4$ super Yang-Mills down to $SO(5)$. We extrapolate the location of this phase transition and compute the expectation value of the resulting scalar operators in the low energy phase.

  9. Globalisation, localisation and implications of a transforming nursing workforce in New Zealand: opportunities and challenges.

    Science.gov (United States)

    Callister, Paul; Badkar, Juthika; Didham, Robert

    2011-09-01

    Severe staff and skill shortages within the health systems of developed countries have contributed to increased migration by health professionals. New Zealand stands out among countries in the Organisation for Economic Co-operation and Development in terms of the high level of movements in and out of the country of skilled professionals, including nurses. In New Zealand, much attention has been given to increasing the number of Māori and Pacific nurses as one mechanism for improving Māori and Pacific health. Against a backdrop of the changing characteristics of the New Zealand nursing workforce, this study demonstrates that the globalisation of the nursing workforce is increasing at a faster rate than its localisation (as measured by the growth of the Māori and New Zealand-born Pacific workforces in New Zealand). This challenges the implementation of culturally appropriate nursing programmes based on the matching of nurse and client ethnicities.

  10. Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action

    Directory of Open Access Journals (Sweden)

    Yuk-Lin Yung

    2017-01-01

    Full Text Available Platelet concentrates (PC generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical results urge the need to understand the working mechanism of PC. It is generally believed that the platelet-derived bioactive factors are the active constituents, and their bioavailability in the vicinity of the lesion sites determines the treatment efficacies. Therefore, the composition, localisation, and duration of the action of PC would be key determinants. In this review, we discuss how different preparations and delivery methods of PC would affect the treatment outcomes with respect to clinical evidence about PC therapy for osteoarthritis, tendinopathies, rotator cuff tears, anterior cruciate ligament injuries, and bone fractures. This review can be used as a quick guide for the use of PC therapy and provide insights for the further optimisation of the therapy in the near future.

  11. Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Chateil, J.F. [Service de Radiologie A, Hopital Pellegrin, Bordeaux (France)]|[Unite de Radiopediatrie, Hopital Pellegrin, Bordeaux (France); Quesson, B.; Thiaudiere, E.; Delalande, C.; Canioni, P. [Resonance Magnetique des Systemes Biologiques, CNRS, Bordeaux (France); Brun, M.; Diard, F. [Service de Radiologie A, Hopital Pellegrin, Bordeaux (France); Sarlangue, J.; Billeaud, C. [Service de Neonatalogie, Hopital Pellegrin, Bordeaux (France)

    1999-03-01

    Objectives. Perinatal hypoxic ischaemic injury is a significant cause of neurodevelopmental impairment. The aim of this study was to evaluate localised proton magnetic resonance spectroscopy ({sup 1}H-MRS) after birth asphyxia. Materials and methods. Thirty newborn infants suspected of having perinatal asphyxia (Apgar score < 3) were studied. The mean gestational age was 37 weeks, mean age at the MR examination was 18 days and mean weight was 2.9 kg. A 1.5-T unit was used for imaging and spectroscopy. None of the babies had mechanically assisted ventilation. No sedation was used. Axial T1-weighted and T2-weighted images were obtained. {sup 1}H-MRS was recorded in a single voxel, localised in white matter, using a STEAM sequence. Results. Image quality was good in 25 of 30 babies. {sup 1}H-MRS was performed in 19 of 30 subjects, with adequate quality in 16. Choline, creatine/phosphocreatine and N-acetylaspartate peaks and peak-area ratios were analysed. Lactate was detected in four infants. The N-acetylaspartate/choline ratio was lower in infants with an impaired neurological outcome, but the difference was not statistically significant. Conclusions. This study suggests that {sup 1}H-MRS may be useful for assessing cerebral metabolism in the neonate. A raised lactate level and decreased N-acetylaspartate/choline ratio may be predictive of a poor outcome. However, in our experience this method is limited by the difficulty in performing the examination during the first hours after birth in critically ill babies, the problems related to use of a monovoxel sequence, the dispersion of the ratios and the lack of determination of the absolute concentration of the metabolites. (orig.) With 3 figs., 2 tabs., 20 refs.

  12. Controlling factors in localised corrosion morphologies observed for magnesium immersed in chloride containing electrolyte.

    Science.gov (United States)

    Williams, Geraint; Birbilis, Nick; McMurray, H Neil

    2015-01-01

    The early stages of localised corrosion affecting magnesium (Mg) surfaces when immersed in aqueous sodium chloride (NaCl) solutions involves the propagation of dark regions, within which both anodic metal dissolution and cathodic hydrogen evolution occur. For nominally "pure" Mg, these dark areas can either take the form of discs which expand radially with time, or filiform-like tracks which lengthen with time. For Mg surfaces which display disc-form corrosion features in concentrated NaCl electrolyte, a transition to filiform corrosion (FFC) is observed as the concentration is decreased, indicating ohmic constraints on radial propagation. A similar effect is observed when Mg specimens of different iron impurity are immersed in a fixed, high concentration NaCl solution, where disc-form corrosion is observed on samples having ≥280 ppm Fe, but FFC predominates at ≤80 ppm Fe. An in situ scanning vibrating electrode technique (SVET) is used to determine current density distributions within the propagating corrosion features. Cathodic current density values of between -100 and -150 A m(-2) measured in central areas of disc-like features are sufficient to sustain the radial growth of a local anode at the perimeter of the discs. However, for high purity Mg specimens (≤80 ppm Fe), cathodic current densities of -10 A m(-2) or less are measured over FFC affected regions, indicating that linear propagation arises when there is insufficient cathodic current produced on the corroded surface to sustain radial growth. The results are consistent with surface control of localised corrosion propagation in concentrated electrolyte, but ohmic control in dilute, lower conductivity NaCl solution.

  13. Peritoneal taurolidine lavage in children with localised peritonitis due to appendicitis.

    Science.gov (United States)

    Schneider, Axel; Sack, Ulrich; Rothe, Karin; Bennek, Joachim

    2005-06-01

    Despite aggressive surgical treatment, rational antibiotic therapy, and modern intensive care, generalised peritonitis remains a major threat in the paediatric age group. Several adjuvant strategies such as peritoneal saline lavage and peritoneal drainage have been utilised. Taurolidine, derived from the amino acid taurine, has bactericidic, antiendotoxic, and antiinflammatory properties. It has been introduced previously for intraoperative peritoneal lavage in treating peritonitis in adults. The aim of our study was to evaluate the effect of peritoneal taurolidine lavage on the clinical course and serological inflammation markers in children with perforated appendicitis and localised peritonitis. A series of 27 children presenting with appendicitis between January 1999 and July 2001 were included in the study after parental informed consent. All patients underwent open appendectomy. Taurolidine peritoneal lavage was applied in 15 randomly selected children (eight girls and seven boys; mean age 10 years and 10 months). Twelve children received saline peritoneal lavage and served as the control group (six girls and six boys; mean age 9 years and 7 months). Blood was taken preoperatively and on postoperative days 1, 3, 7, and 14. Full blood cell count, C-reactive protein, endotoxin, interleukin-1, interleukin-6, soluble interleukin-2 receptor, tumour necrosis factor alpha, and procalcitonin were investigated to evaluate the serological course of inflammation. Both groups initially presented with severe inflammation as evidenced clinically and serologically. The clinical postoperative course was uneventful in 13/15 patients in the treatment group and 10/12 patients in the control group. The remaining patients presented complications: intraperitoneal abscess or early postoperative bowel obstruction. With regard to the serological inflammatory parameters, no significant differences were found between the two groups except for the soluble interleukin-2-receptor on the 7

  14. Expression and localisation of BDNF, NT4 and TrkB in proliferative vitreoretinopathy.

    Science.gov (United States)

    Ghazi-Nouri, Seyed M S; Ellis, James S; Moss, Stephen; Limb, G Astrid; Charteris, David G

    2008-05-01

    Exogenous brain derived neurotrophic factor (BDNF) is known to rescue ganglion cell death after optic nerve injury. Its mechanism of action is believed to be indirect via glial cells in the retina. In this study we investigated the changes in expression and localisation of BDNF, neurotrophin-4 (NT4) and their common receptor (TrkB) in retinectomy sections of patients with proliferative vitreoretinopathy (PVR). Nine full-thickness retinectomy specimens obtained at retinal reattachment surgery for PVR were fixed in 4% paraformaldehyde immediately after excision and compared to similarly processed normal donor retinas (4 eyes). Agarose-embedded sections (100 microm thick) were double labelled for immunohistochemistry by confocal microscopy, with antibodies against BDNF, NT4, TrkB, rod opsin, glial fibrillary acidic protein (GFAP), cellular retinaldehyde binding protein (CRALBP) and Brn3. This study demonstrates expression of NT4 by ganglion cells and shows expression of BDNF and NT4 in the outer photoreceptor segments is downregulated during PVR, whilst NT4 is markedly upregulated throughout the retina during this condition. The findings here suggest that NT4 may play a neural protective role during the development of PVR. It also shows that upregulation of NT4 in PVR is localised to Müller glial cells, indicating either over-expression of this factor by Müller cells or that Müller cells internalise NT4 for trafficking across the retina. TrkB expression was not observed in PVR retina. The observations that Müller glia demonstrate upregulation of NT4 suggests that retinal injury may lead to activation of this neurotrophin by Müller cells as part of their neuroprotective functions.

  15. FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype

    Directory of Open Access Journals (Sweden)

    Thompson Alastair M

    2011-03-01

    Full Text Available Abstract Background Single Nucleotide Polymorphisms (SNPs in intron 2 of the Fibroblast Growth Factor Receptor Type 2 (FGFR2 gene, including rs2981582, contribute to multifactorial breast cancer susceptibility. The high risk polymorphism haplotype in the FGFR2 gene has been associated with increased mRNA transcription and altered transcription factor binding but the effect on FGFR2 protein expression is unknown. 40 breast tumours were identified from individuals with known rs2981582 genotype. Tumour sections were stained for FGFR2 protein expression, and scored for nuclear and cytoplasmic staining in tumour and surrounding normal tissue. Findings FGFR2 immunohistochemistry demonstrated variable nuclear staining in normal tissue and tumour tissue, as well as consistent cytoplasmic staining. We did not find an association between nuclear staining for FGFR2 and genotype, and there was no association between FGFR2 staining and estrogen or progestogen receptor status. There was an association between presence of nuclear staining for FGFR2 in normal tissue and presence of nuclear staining in the adjacent tumour (Fishers exact test, p = 0.002. Conclusions Variable nuclear staining for FGFR2 in breast cancer, but an absence of correlation with rs2981582 genotype suggests that the mechanism of action of polymorphisms at the FGFR2 locus may be more complex than a direct effect on mRNA expression levels in the final cancer. The effect may relate to FGFR2 function or localisation during breast development or tumourigenesis. Nuclear localisation of FGFR2 suggests an important additional role for this protein in breast development and breast cancer, in addition to its function as a classical cell surface receptor.

  16. Acoustic Measurements for Determination of the Materials Damping Using A Sound Source Localisation System

    Institute of Scientific and Technical Information of China (English)

    J. G(o)ken; J. Swiostek; H. Hurdelbrink; U. Keil

    2013-01-01

    Noise measurements are especially a problem when the object under investigation is largely dimensioned and can only be measured from the distance.To obtain information about the location of noise generation,a measurement technique which makes sound visible in order to introduce further specific technical measures is advantageous.The question is if the time dependence of the signal got from such a non touching and non destructive acoustic method has the potential to calculate the materials damping from.Using a small sound source localization system (MicroflownTM probe),specimens of magnesium alloys with different grain sizes obtained by hydrostatic extrusion were investigated.It has been demonstrated that the fine grained microstructure led to a lower damping and its dependence on the strain was reduced.In this context,acoustic measurements by a sound source localisation system which makes materials characterization possible could be used as a quality tool to detect changes in highly stressed components.This approach allows to promote a selective substitution of conventional materials by more innovative ones.The offshore sector is considered to be a field of application:Wind turbines produce noise emission which stems mainly from turbulences at the tips of the rotor blades and vibrations of components inside the nacelle (e.g.gearbox,generator,…).If the vibration amplitudes are too high,microcracks of components can lead to failure over the long term.The monitoring of microstructural changes using a larger type of a sound source localisation system is considered as an innovative technical approach with respect to maintenance activities.

  17. Magnetic resonance spectroscopy as a decision tool in multimodality treatment design for localised prostate cancer

    Directory of Open Access Journals (Sweden)

    Giuseppe Sasso

    2011-12-01

    Full Text Available Predicting the outcome of individual prostate adenocarcinoma can be challenging, especially for patients affected by intermediate or high risk, but localised disease. Natural histories of prostate cancers with similar stage and prognostic factors can differ significantly; and an ongoing debate surrounds the optimal treatment choice for men diagnosed with non-metastatic prostate cancer. A variety of effective therapeutic options are available to be used as a sole modality, or in combination, including surgery, external beam radiotherapy, brachytherapy, and endocrine manipulation. Although these treatments have been used routinely for more than 15 years, there is a paucity of data from randomised trials comparing their results. In addition, most treatment techniques have changed dramatically in the last two decades due to the ongoing healthcare technological revolution. The rapid proliferation of new and expensive therapeutic options (i.e. adaptive radiotherapy, focal ablation, etc. promises to minimise treatment related side effects and improve local control, however, there is no uniform consensus. Treatment choice is based on the available prognostic factors and life expectancy, along with patient preference, toxicity profiles, the individual institution’s (and clinician’s experience and resource availability. Unfortunately, our prognostic tools are still limited, as is our ability to precisely predict which subset of patients might benefit from more aggressive therapeutic combinations. Therefore, a significant number of patients receive unnecessary and expensive treatments, whilst others are denied highly technological procedures because of associated resource limitation. This paper aims to analyse the current evidence, cost-effectiveness and controversies, surrounding the nonsurgical treatment of localised prostate cancer, with a focus on radiation and endocrine therapies, and to discuss the role of magnetic resonance spectroscopy, as a

  18. Group localisation and unsupervised detection and classification of basic crowd behaviour events for surveillance applications

    Science.gov (United States)

    Roubtsova, Nadejda S.; de With, Peter H. N.

    2013-02-01

    Technology for monitoring crowd behaviour is in demand for surveillance and security applications. The trend in research is to tackle detection of complex crowd behaviour events (panic, ght, evacuation etc.) directly using machine learning techniques. In this paper, we present a contrary, bottom-up approach seeking basic group information: (1) instantaneous location and (2) the merge, split and lateral slide-by events - the three basic motion patterns comprising any crowd behaviour. The focus on such generic group information makes our algorithm suitable as a building block in a variety of surveillance systems, possibly integrated with static content analysis solutions. Our feature extraction framework has optical ow in its core. The framework is universal being motion-based, rather than object-detection-based and generates a large variety of motion-blob- characterising features useful for an array of classi cation problems. Motion-based characterisation is performed on a group as an atomic whole and not by means of superposition of individual human motions. Within that feature space, our classi cation system makes decisions based on heuristic rules and thresholds, without machine learning. Our system performs well on group localisation, consistently generating contours around both moving and halted groups. The visual output of our periodical group localisation is equivalent to tracking and the group contour accuracy ranges from adequate to exceptionally good. The system successfully detects and classi es within our merge/split/slide-by event space in surveillance-type video sequences, di ering in resolution, scale, quality and motion content. Quantitatively, its performance is characterised by a good recall: 83% on detection and 71% on combined detection and classi cation.

  19. Salade malade: malignant ventricular arrhythmias due to an accidental intoxication with Aconitum napellus

    OpenAIRE

    Weijters, B.J.; Verbunt, R.J.A.M.; Hoogsteen, J.; Visser, R.F.

    2008-01-01

    Intoxication with Aconitum napellus is rare in our regions. Aconite alkaloids can cause ventricular arrhythmia by a prolonged activation of sodium channels. Because the margin of safety is low between the analgesic and toxic dose, intoxication is not rare when Aconite is used in herbal medicine. We present a case in which a 39-year-old male was accidentally intoxicated with Aconite. Even though no antidote or adequate therapy is available he was successfully resuscitated. (Neth Heart J 2008;1...

  20. The Impacts of Air Temperature on Accidental Casualties in Beijing, China

    Science.gov (United States)

    Ma, Pan; Wang, Shigong; Fan, Xingang; Li, Tanshi

    2016-01-01

    Emergency room (ER) visits for accidental casualties, according to the International Classification of Deceases 10th Revision Chapters 19 and 20, include injury, poisoning, and external causes (IPEC). Annual distribution of 187,008 ER visits that took place between 2009 and 2011 in Beijing, China displayed regularity rather than random characteristics. The annual cycle from the Fourier series fitting of the number of ER visits was found to explain 63.2% of its total variance. In this study, the possible effect and regulation of meteorological conditions on these ER visits are investigated through the use of correlation analysis, as well as statistical modeling by using the Distributed Lag Non-linear Model and Generalized Additive Model. Correlation analysis indicated that meteorological variables that positively correlated with temperature have a positive relationship with the number of ER visits, and vice versa. The temperature metrics of maximum, minimum, and mean temperatures were found to have similar overall impacts, including both the direct impact on human mental/physical conditions and indirect impact on human behavior. The lag analysis indicated that the overall impacts of temperatures higher than the 50th percentile on ER visits occur immediately, whereas low temperatures show protective effects in the first few days. Accidental casualties happen more frequently on warm days when the mean temperature is higher than 14 °C than on cold days. Mean temperatures of around 26 °C result in the greatest possibility of ER visits for accidental casualties. In addition, males were found to face a higher risk of accidental casualties than females at high temperatures. Therefore, the IPEC-classified ER visits are not pure accidents; instead, they are associated closely with meteorological conditions, especially temperature. PMID:27827842

  1. The Impacts of Air Temperature on Accidental Casualties in Beijing, China

    Directory of Open Access Journals (Sweden)

    Pan Ma

    2016-11-01

    Full Text Available Emergency room (ER visits for accidental casualties, according to the International Classification of Deceases 10th Revision Chapters 19 and 20, include injury, poisoning, and external causes (IPEC. Annual distribution of 187,008 ER visits that took place between 2009 and 2011 in Beijing, China displayed regularity rather than random characteristics. The annual cycle from the Fourier series fitting of the number of ER visits was found to explain 63.2% of its total variance. In this study, the possible effect and regulation of meteorological conditions on these ER visits are investigated through the use of correlation analysis, as well as statistical modeling by using the Distributed Lag Non-linear Model and Generalized Additive Model. Correlation analysis indicated that meteorological variables that positively correlated with temperature have a positive relationship with the number of ER visits, and vice versa. The temperature metrics of maximum, minimum, and mean temperatures were found to have similar overall impacts, including both the direct impact on human mental/physical conditions and indirect impact on human behavior. The lag analysis indicated that the overall impacts of temperatures higher than the 50th percentile on ER visits occur immediately, whereas low temperatures show protective effects in the first few days. Accidental casualties happen more frequently on warm days when the mean temperature is higher than 14 °C than on cold days. Mean temperatures of around 26 °C result in the greatest possibility of ER visits for accidental casualties. In addition, males were found to face a higher risk of accidental casualties than females at high temperatures. Therefore, the IPEC-classified ER visits are not pure accidents; instead, they are associated closely with meteorological conditions, especially temperature.

  2. Modelling accidental hypothermia effects on a human body under different pathophysiological conditions

    OpenAIRE

    Coccarelli, Alberto; Boileau, Etienne; Parthimos, Dimitris; Nithiarasu, Perumal

    2017-01-01

    Accidental exposure to cold water environment is one of the most challenging situations in which hypothermia occurs. In the present work, we aim to characterise the energy balance of a human body subjected to such extreme environmental conditions. This study is carried out using a recently developed computational model and by setting boundary conditions needed to simulate the effect of cold surrounding environment. A major finding is the capacity of the body core regions to maintain their tem...

  3. Current controversies in the interpretation of non-accidental head injury

    Energy Technology Data Exchange (ETDEWEB)

    Jaspan, Tim [Imaging Centre, University Hospital, Nottingham (United Kingdom)

    2008-06-15

    The field of non-accidental injury (NAI) has been the subject of a number of theories and hypotheses of variable merit. Concerning injuries that occur within the intracranial compartment, much research has been undertaken to investigate the cause of SDH and parenchymal brain injury. Much, however, remains contentious, particularly regarding the medicolegal aspects of suspected child abuse. Issues that present the greatest challenges will be addressed. (orig.)

  4. Artritis tuberculosa - Autoinoculación en profesional sanitario por accidente laboral

    Directory of Open Access Journals (Sweden)

    Sara Cardoso

    2012-12-01

    Los autores describen un caso de monoartritis tuberculosa en un médico traumatólogo previamente sano, por inoculación accidental durante el drenaje quirúrgico de una artritis séptica. El tratamiento oral con fármacos antituberculosos y el drenaje quirúrgico fueron suficientes, sin tener que recurrir a la sinovectomía.

  5. Accidental PUVA burns, vitiligo and atopic diathesis resulting in prurigo nodularis: a logical but undocumented rarity*

    Science.gov (United States)

    Verma, Shyam Bhanushankar; Wollina, Uwe

    2012-01-01

    Vitiligo is a dreaded disease in India due to its social and cultural consequences. PUVA and PUVAsol are the main treatment modalities for vitiligo vulgaris. To the best of our knowledge, this is the first case of accidental PUVA burns eventuating in prurigo nodularis lesions to be reported in a female patient who was undergoing home PUVA therapy. The itch is so prominent and disabling that the focus of the patient has shifted from treating her vitiligo to ameliorating the pruritus. PMID:23197209

  6. Cuidado popular de familias con un adulto mayor sobreviviente del primer accidente cerebrovascular

    OpenAIRE

    Lucero López-Díaz; Fabiola Castellanos-Soriano; Esperanza Muñoz-Torres

    2016-01-01

    Introducción: el accidente cerebrovascular afecta a numerosas personas en el mundo y se constituye en la principal causa de muer- te. Los sobrevivientes pueden padecer discapacidad y sufrir modificaciones en las actividades cotidianas. La familia es el principal apoyo del sobreviviente y al ser parte de una misma cultura, construye acciones de cuidado en búsqueda del bienestar. Objetivo: describir las acciones del cuidado popular de las familias con un adulto mayor sobreviviente del prim...

  7. Analizan partículas calientes del accidente nuclear de Palomares

    OpenAIRE

    2012-01-01

    Investigadores pertenecientes al Centro Nacional de Aceleradores, CNA, (Universidad de Sevilla-Junta de Andalucía-CSIC) en colaboración con la Organización Internacional de la Energía Atómica (IAEA), han llevado a cabo me didas de elementos transuránicos en partículas calientes procedentes de accidentes nucleares tales como el de Thule (Groenlandia) o Palomares (España).

  8. [Fatal accidental mixed poisoning of 3 men at the same time].

    Science.gov (United States)

    Minnasch, P; Reiter, A; Meissner, C; Oehmichen, M

    1999-01-01

    The case history presented reports on three 30- to 40-years-old men, who were found dead in a party like situation in the living room. The toxicological investigation proved alcohol and THC as well as therapeutic Flunitrazepam- and Pentobarbital levels and toxic 7- Amino-Flunitrazepam concentrations. The background of this surprising scene led up to the conclusion of an accidental death caused by a mixed intoxication.

  9. Immunohistochemical localisation of TRA-1-60, TRA-1-81, GCTM-2 and podocalyxin in the developing baboon kidney.

    Science.gov (United States)

    Gubhaju, Lina; Laslett, Andrew; Bertram, John F; Zulli, Anthony; Black, M Jane

    2008-05-01

    The baboon is an ideal animal model to study human kidney development. The aim of the current study was to use immunohistochemistry to localise the antigens TRA-1-60, TRA-1-81, GCTM-2 and podocalyxin in the developing baboon kidney where nephrogenesis was still on-going and in kidneys where nephrogenesis was complete. Fixed kidney sections from baboons delivered at 125, 140, 175 and 185 days gestation (term = 185 days) were immuno-labelled with antibodies directed against TRA-1-60, TRA-1-81, GCTM-2 and podocalyxin. In kidneys with on-going nephrogenesis (125 and 140 days gestation), TRA-1-60, TRA-1-81 and GCTM-2 were specifically localised to the apical plasma membrane of the epithelium of the ureteric ampullae and the collecting ducts, while podocalyxin immunostaining was not detected. In kidneys where nephrogenesis was complete (175 and 185 days gestation) localisation of these markers was again very specifically localised to the collecting ducts. In conclusion, although further experimentation is required to confirm the identity of the specific cell types marked by these antibodies, this study provides new insight into the distribution of commonly utilised stem cell antibodies in the developing baboon kidney.

  10. Correlative and integrated light and electron microscopy of in-resin GFP fluorescence, used to localise diacylglycerol in mammalian cells

    Energy Technology Data Exchange (ETDEWEB)

    Peddie, Christopher J.; Blight, Ken; Wilson, Emma [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Melia, Charlotte [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Department of Molecular Cell Biology, Leiden University Medical Centre, 2300 RC Leiden (Netherlands); Marrison, Jo [Department of Biology, The University of York, Heslington, York (United Kingdom); Carzaniga, Raffaella [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Domart, Marie-Charlotte [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); O' Toole, Peter [Department of Biology, The University of York, Heslington, York (United Kingdom); Larijani, Banafshe [Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, Unidad de Biofísica (CSIC-UPV/EHU),Sarriena s/n, 48940 Leioa (Spain); IKERBASQUE, Basque Foundation for Science, Bilbao (Spain); Collinson, Lucy M. [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom)

    2014-08-01

    Fluorescence microscopy of GFP-tagged proteins is a fundamental tool in cell biology, but without seeing the structure of the surrounding cellular space, functional information can be lost. Here we present a protocol that preserves GFP and mCherry fluorescence in mammalian cells embedded in resin with electron contrast to reveal cellular ultrastructure. Ultrathin in-resin fluorescence (IRF) sections were imaged simultaneously for fluorescence and electron signals in an integrated light and scanning electron microscope. We show, for the first time, that GFP is stable and active in resin sections in vacuo. We applied our protocol to study the subcellular localisation of diacylglycerol (DAG), a modulator of membrane morphology and membrane dynamics in nuclear envelope assembly. We show that DAG is localised to the nuclear envelope, nucleoplasmic reticulum and curved tips of the Golgi apparatus. With these developments, we demonstrate that integrated imaging is maturing into a powerful tool for accurate molecular localisation to structure. - Highlights: • GFP and mCherry fluorescence are preserved in heavy-metal stained mammalian cells embedded in resin • Fluorophores are stable and intensity is sufficient for detection in ultrathin sections • Overlay of separate LM and EM images from the same ultrathin section improves CLEM protein localisation precision • GFP is stable and active in the vacuum of an integrated light and scanning EM • Integrated light and electron microscopy shows new subcellular locations of the lipid diacylglycerol.

  11. Three-Dimensional Passive Source Localisation using the Flank Array of an Autonomous Underwater Vehicle in Shallow Water

    Directory of Open Access Journals (Sweden)

    Dexin Zhao

    2013-05-01

    Full Text Available Researchers have become interested in autonomous underwater vehicles equipped with various kinds of sonar systems that can perform many of underwater tasks, which is encouraged by the potential benefits of cost reduction and flexible deployment. This paper proposes an approach to three-dimensional passive source localisation with the flank array of an autonomous underwater vehicle in shallow water. The approach is developed based on matched-field processing for the likelihood of passive source localisation in the shallow water environment. Inter-position processing is also used for the improved localisation performance and the enhanced stability of the estimation process against the lack of spatial gain due to the small physical size of the flank array. The proposed approach is presented and validated through simulation and experimental data. The results illustrate the localisation performance at different signal-to-noise ratios and demonstrate the build up over time of the positional parameters of the estimated source as the autonomous underwater vehicle cruises at a low speed along a straight line at a constant depth.Defence Science Journal, 2013, 63(3, pp.323-330, DOI:http://dx.doi.org/10.14429/dsj.63.3011

  12. Three-Dimensional Passive Source Localisation using the Flank Array of an Autonomous Underwater Vehicle in Shallow Water

    Directory of Open Access Journals (Sweden)

    Dexin Zhao

    2013-05-01

    Full Text Available Researchers have become interested in autonomous underwater vehicles equipped with various kinds of sonar systems that can perform many of underwater tasks, which is encouraged by the potential benefits of cost reduction and flexible deployment. This paper proposes an approach to three-dimensional passive source localisation with the flank array of an autonomous underwater vehicle in shallow water. The approach is developed based on matched-field processing for the likelihood of passive source localisation in the shallow water environment. Inter-position processing is also used for the improved localisation performance and the enhanced stability of the estimation process against the lack of spatial gain due to the small physical size of the flank array. The proposed approach is presented and validated through simulation and experimental data. The results illustrate the localisation performance at different signal-to-noise ratios and demonstrate the build up over time of the positional parameters of the estimated source as the autonomous underwater vehicle cruises at a low speed along a straight line at a constant depth.

  13. Strain localisation and population changes during fault system growth within the Inner Moray Firth, Northern North Sea

    Science.gov (United States)

    Walsh, J. J.; Childs, C.; Imber, J.; Manzocchi, T.; Watterson, J.; Nell, P. A. R.

    2003-02-01

    The evolution of fault populations is established for an area within the Late Jurassic Inner Moray Firth sub-basin of the North Sea. Sedimentation rates outstripped fault displacement rates resulting in the blanketing of fault scarps and the preservation of fault displacement histories. Displacement backstripping is used to establish the growth history of the fault system. Fault system evolution is characterised by early generation of the main fault pattern and progressive localisation of strain onto larger faults. This localisation is accompanied by the death of smaller faults and an associated change in the active fault population from power-law to scale-bound. Fault length populations evolve from a power-law frequency distribution containing all faults, to a power-law distribution with a marked non-power-law tail containing the largest faults. This change in population character is synchronous with the development of a fully-connected fault system extending across the mapped area and the accommodation of displacements almost exclusively on the largest faults. Strain localisation onto fewer and better connected faults represents the most efficient means of accommodating fault-related deformation and is considered to be a fundamental characteristic of the spatio-temporal evolution of fault systems. Progressive strain localisation requires complementary changes in the characteristics of associated earthquake populations.

  14. Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust.

    Science.gov (United States)

    Kumichel, Alexandra; Knust, Elisabeth

    2014-01-01

    The transmembrane protein Crumbs/Crb is a key regulator of apico-basal epithelial cell polarity, both in Drosophila and in vertebrates. In most cases studied so far, the apical localisation of Drosophila Crumbs depends on the interaction of its C-terminal amino acids with the scaffolding protein Stardust. Consequently, embryos lacking either Crumbs or Stardust develop a very similar phenotype, characterised by the loss of epithelial tissue integrity and cell polarity in many epithelia. An exception is the hindgut, which is not affected by the loss of either gene. The hindgut is a single layered epithelial tube composed of two cell populations, the boundary cells and the principal cells. Here we show that Crumbs localisation in the principal cells depends on Stardust, similarly to other embryonic epithelia. In contrast, localisation of Crumbs in the boundary cells does not require Stardust and is independent of its PDZ domain- and FERM-domain binding motifs. In line with this, the considerable upregulation of Crumbs in boundary cells is not followed by a corresponding upregulation of its canonical binding partners. Our data are the first to suggest a mechanism controlling apical Crumbs localisation, which is independent of its conserved FERM- and PDZ-domain binding motifs.

  15. Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust.

    Directory of Open Access Journals (Sweden)

    Alexandra Kumichel

    Full Text Available The transmembrane protein Crumbs/Crb is a key regulator of apico-basal epithelial cell polarity, both in Drosophila and in vertebrates. In most cases studied so far, the apical localisation of Drosophila Crumbs depends on the interaction of its C-terminal amino acids with the scaffolding protein Stardust. Consequently, embryos lacking either Crumbs or Stardust develop a very similar phenotype, characterised by the loss of epithelial tissue integrity and cell polarity in many epithelia. An exception is the hindgut, which is not affected by the loss of either gene. The hindgut is a single layered epithelial tube composed of two cell populations, the boundary cells and the principal cells. Here we show that Crumbs localisation in the principal cells depends on Stardust, similarly to other embryonic epithelia. In contrast, localisation of Crumbs in the boundary cells does not require Stardust and is independent of its PDZ domain- and FERM-domain binding motifs. In line with this, the considerable upregulation of Crumbs in boundary cells is not followed by a corresponding upregulation of its canonical binding partners. Our data are the first to suggest a mechanism controlling apical Crumbs localisation, which is independent of its conserved FERM- and PDZ-domain binding motifs.

  16. Exploring the Function of Online Narratives to Develop Critical Thinking and Localisation of Knowledge in an International Science Program

    Science.gov (United States)

    Hicks, Marianne; Tham, Melissa; Brookes, Rowan

    2017-01-01

    e-learning practitioners have long recognised the benefits of using online training to achieve knowledge transfer, less is understood about facilitating the sharing of values, attitudes, critical thinking, and localisation using online platforms. In this article an online learning platform in the context of an international scientific program was…

  17. Exploring the Function of Online Narratives to Develop Critical Thinking and Localisation of Knowledge in an International Science Program

    Science.gov (United States)

    Hicks, Marianne; Tham, Melissa; Brookes, Rowan

    2017-01-01

    e-learning practitioners have long recognised the benefits of using online training to achieve knowledge transfer, less is understood about facilitating the sharing of values, attitudes, critical thinking, and localisation using online platforms. In this article an online learning platform in the context of an international scientific program was…

  18. The budding yeast Dbf2 protein kinase localises to the centrosome and moves to the bud neck in late mitosis.

    Science.gov (United States)

    Frenz, L M; Lee, S E; Fesquet, D; Johnston, L H

    2000-10-01

    Dbf2 is a multifunctional protein kinase in Saccharomyces cerevisiae that functions in transcription, the stress response and as part of a network of genes in exit from mitosis. By analogy with fission yeast it seemed likely that these mitotic exit genes would be involved in cytokinesis. As a preliminary investigation of this we have used Dbf2 tagged with GFP to examine intracellular localisation of the protein in living cells. Dbf2 is found on the centrosomes/spindle pole bodies (SPBs) and also at the bud neck where it forms a double ring. The localisation of Dbf2 is cell cycle regulated. It is on the SPBs for much of the cell cycle and migrates from there to the bud neck in late mitosis, consistent with a role in cytokinesis. Dbf2 partly co-localises with septins at the bud neck. A temperature-sensitive mutant of dbf2 also blocks progression of cytokinesis at 37 degrees C. Following cytokinesis some Dbf2 moves into the nascent bud. Localisation to the bud neck depends upon the septins and also the mitotic exit network proteins Mob1, Cdc5, Cdc14 and Cdc15. The above data are consistent with Dbf2 acting downstream in a pathway controlling cytokinesis.

  19. Los accidentes laborales, su impacto económico y social

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    Miguel Antonio Cisneros-Prieto

    2015-01-01

    Full Text Available Este artículo investigativo aborda la problemática de los accidentes de trabajo en las empresas estatales en la provincia Holguín y la importancia de la determinación efectiva de las causas que los provocan, a partir del análisis del comportamiento de los indicadores emitidos por la Oficina Nacional de Estadística e Información (ONEI hasta el año 2014. Se analiza el comportamiento, en el período comprendido entre el 2011-2014, de las cifras de trabajadores lesionados y fallecidos, y se evalúa el impacto humano, económico y social de la accidentalidad en las empresas y la sociedad. Se demuestra un incremento en el indicador “Días perdidos por accidentados”, siendo la principal lectura de este comportamiento el aumento de la gravedad de los accidentes de trabajo, este es un elemento que generalmente las organizaciones no valoran en su verdadera magnitud como un significativo impacto negativo de su eficiencia económica y financiera. Se presenta un enfoque sobre las potencialidades de la comunicación en función de la solución o atenuación de la ocurrencia de los accidentes y en consecuencia ladisminución del costo financiero y social de esta compleja problemática.

  20. Mortalidad por accidentes de tránsito en Bayamo, Cuba 2011

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    Arlines Piña-Tornés

    2014-10-01

    Full Text Available Con el objetivo de describir la mortalidad por accidentes de tránsito en Bayamo, Cuba, en el año 2011 se realizó una revisión de los pacientes lesionados y fallecidos a causa de accidentes de tránsito, registrados en Hospital Carlos M. de Céspedes. Se atendieron en emergencias 1365 lesionados, predominando el grupo etario de 25 a 44 años con 372 pacientes (27,3%, y el sexo masculino con 1071 (78,5%. Fallecieron 46 personas, en su mayoría del mismo grupo de edad y de sexo masculino. Los traumatismos múltiples (52,6% y cráneofaciales (34,2% fueron las localizaciones predominantes. Se destacaron los atropellos por vehículo de motor con mortalidad del 26,3%. En conclusión, la mortalidad por accidentes de tránsito predomina en adultos jóvenes masculinos; cuyas consecuencias fatales son debido a traumatismos múltiples por atropellos.