WorldWideScience

Sample records for accessing human knowledge

  1. Accessible Knowledge - Knowledge on Accessibility

    DEFF Research Database (Denmark)

    Kirkeby, Inge Mette

    2015-01-01

    Although serious efforts are made internationally and nationally, it is a slow process to make our physical environment accessible. In the actual design process, architects play a major role. But what kinds of knowledge, including research-based knowledge, do practicing architects make use of when...... designing accessible environments? The answer to the question is crucially important since it affects how knowledge is distributed and how accessibility can be ensured. In order to get first-hand knowledge about the design process and the sources from which they gain knowledge, 11 qualitative interviews...... were conducted with architects with experience of designing for accessibility. The analysis draws on two theoretical distinctions. The first is research-based knowledge versus knowledge used by architects. The second is context-independent knowledge versus context-dependent knowledge. The practitioners...

  2. New ways of scientific publishing and accessing human knowledge inspired by transdisciplinary approaches

    CERN Document Server

    Gebeshuber, I C

    2010-01-01

    Inspired by interdisciplinary work touching biology and microtribology, the authors propose a new, dynamic way of publishing research results, the establishment of a tree of knowledge and the localisation of scientific articles on this tree. 'Technomimetics' is proposed as a new method of knowledge management in science and technology: it shall help find and organise information in an era of over-information. Such ways of presenting and managing research results would be accessible by people with different kinds of backgrounds and levels of education, and allow for full use of the ever- increasing number of scientific and technical publications. This approach would dramatically change and revolutionize the way we are doing science, and contribute to overcoming the three gaps between the world of ideas, inventors, innovators and investors as introduced by Gebeshuber, Gruber and Drack in 2009 for accelerated scientific and technological breakthroughs to improve the human condition. Inspiration for the developme...

  3. Accessing vs Sourcing Knowledge

    DEFF Research Database (Denmark)

    Awate, Snehal; Larsen, Marcus M.; Mudambi, Ram

    2015-01-01

    Research and development (R&D) internationalization is on the rise for advanced economy multinationals (AMNEs) as well as emerging economy multinationals (EMNEs). We study EMNE R&D internationalization by comparing it to that by AMNEs in the context of an emerging, knowledge-intensive industry. We...... to get on par with industry leaders. An in-depth comparison of knowledge flows reveals that within AMNEs, headquarters often serves the primary source of knowledge for R&D subsidiaries. In contrast, within EMNEs, headquarters accesses knowledge from R&D subsidiaries in advanced economies for innovation...

  4. Accessing Remote Knowledge

    DEFF Research Database (Denmark)

    Maskell, Peter

    2014-01-01

    Work on clusters during the last few decades convincingly demonstrates enhanced opportunities for local growth and entrepreneurship, but external upstream knowledge linkages are often overlooked or taken for granted. This article is an attempt to remedy this situation by investigating why and how...... young, single-site firms search for distant sources of complementary competences. The discussion is positioned within a comprehensive framework that allows a systematic investigation of the approaches available to firms engaged in globally extended learning. By utilizing the distinction between problem...... awareness (what remote knowledge is needed?) and source awareness (where does this knowledge reside?) the article explores the relative merits and inherent limitations of pipelines, listening posts, crowdsourcing and trade fairs to acquire knowledge and solutions from geographically and relationally remote...

  5. Learning Task Knowledge from Dialog and Web Access

    Directory of Open Access Journals (Sweden)

    Vittorio Perera

    2015-06-01

    Full Text Available We present KnoWDiaL, an approach for Learning and using task-relevant Knowledge from human-robot Dialog and access to the Web. KnoWDiaL assumes that there is an autonomous agent that performs tasks, as requested by humans through speech. The agent needs to “understand” the request, (i.e., to fully ground the task until it can proceed to plan for and execute it. KnoWDiaL contributes such understanding by using and updating a Knowledge Base, by dialoguing with the user, and by accessing the web. We believe that KnoWDiaL, as we present it, can be applied to general autonomous agents. However, we focus on our work with our autonomous collaborative robot, CoBot, which executes service tasks in a building, moving around and transporting objects between locations. Hence, the knowledge acquired and accessed consists of groundings of language to robot actions, and building locations, persons, and objects. KnoWDiaL handles the interpretation of voice commands, is robust regarding speech recognition errors, and is able to learn commands involving referring expressions in an open domain, (i.e., without requiring a lexicon. We present in detail the multiple components of KnoWDiaL, namely a frame-semantic parser, a probabilistic grounding model, a web-based predicate evaluator, a dialog manager, and the weighted predicate-based Knowledge Base. We illustrate the knowledge access and updates from the dialog and Web access, through detailed and complete examples. We further evaluate the correctness of the predicate instances learned into the Knowledge Base, and show the increase in dialog efficiency as a function of the number of interactions. We have extensively and successfully used KnoWDiaL in CoBot dialoguing and accessing the Web, and extract a few corresponding example sequences from captured videos.

  6. Access to Information About Stuttering and Societal Knowledge of Stuttering

    OpenAIRE

    Gabel, Rodney; Brackenbury, Tim; Irani, Farzan

    2010-01-01

    The purpose of this study was to examine societal knowledge of stuttering, access to information sources, and the influence of information sources on knowledge of stuttering. 185 participants from Northwest Ohio were surveyed. Results of the study indicated that the general public varies in their knowledge of stuttering and that majority of participants had not accessed information about stuttering, and the few who had, did so a long time ago. Finally, access to information sources had little...

  7. Access to Information About Stuttering and Societal Knowledge of Stuttering

    OpenAIRE

    Gabel, Rodney; Brackenbury, Tim; Irani, Farzan

    2010-01-01

    The purpose of this study was to examine societal knowledge of stuttering, access to information sources, and the influence of information sources on knowledge of stuttering. 185 participants from Northwest Ohio were surveyed. Results of the study indicated that the general public varies in their knowledge of stuttering and that majority of participants had not accessed information about stuttering, and the few who had, did so a long time ago. Finally, access to information sources had little...

  8. Knowledge Access Based on the Rough Set Theory

    Institute of Scientific and Technical Information of China (English)

    HAN Yan-ling; YANG Bing-ru; CAO Shou-qi

    2005-01-01

    During the procedure of fault diagnosis for large-scale complicated equipment, the existence of redundant and fuzzy information results in the difficulty of knowledge access. Aiming at this characteristic, this paper brought forth the Rough Set (RS) theory to the field of fault diagnosis. By means of the RS theory which is predominant in the way of dealing with fuzzy and uncertain information,knowledge access about fault diagnosis was realized. The foundation ideology of the RS theory was exhausted in detail, an amended RS algorithm was proposed, and the process model of knowledge access based on the amended RS algorithm was researched. Finally, we verified the correctness and the practicability of this method during the procedure of knowledge access.

  9. Semantic Externalism and Self Knowledge: Privileged Access to the World

    OpenAIRE

    Sawyer, Sarah

    2008-01-01

    The thesis is concerned to defend the compatibility of two plausible claims about the mind; semantic externalism and privileged access. It is further concerned to demonstrate one important implication of the conjunction of semantic externalism and privileged access, an implication which forces the rejection of the dichotomy between knowledge of one’s mind and knowledge of one’s world. Chapter one is a presentation of semantic externalism. Chapter two is a presentation of the claim of privileg...

  10. Access to Medicines and Human Rights

    NARCIS (Netherlands)

    Oehlke, Krista; Perehudoff, Katrina; Geddes, Katrina; Ruiz Mancera, Silvia; Fuller, Arlan

    This chapter will introduce you to key issues and resources in access to medicines and human rights. In addition, this chapter will help you understand why, more now than ever, access to medicines must be understood and approached as a human rights issue. Some of these issues are also addressed in

  11. Open access to scientific knowledge and feudalism knowledge: Is there a connection?

    Directory of Open Access Journals (Sweden)

    Vladimir M. Moskovkin

    2011-06-01

    Full Text Available The role of universities and transnational corporations in the circulation of scientific knowledge is considered. If institutions generate, mostly scientific knowledge, trying to facilitate its free circulation, then transnational companies, contrarily, try to remove most significant and cutting-edge scientific knowledge from free circulation and its commercialization and reintroduction into an open, but now commercial, circulation in the TRIPS. However, paradoxical, the open access movement to scientific knowledge, eventually, facilitates feudalism of knowledge. We call this phenomenon the "open access - paradox". Based on the experiments done with Google Scholar and Google Patents, it is shown that universities generates, mostly scientific knowledge (scientific articles, and transnational companies generates, mostly technological knowledge (patents.

  12. Open access to scientific knowledge and feudalism knowledge: Is there a connection?

    OpenAIRE

    Vladimir M. Moskovkin

    2011-01-01

    The role of universities and transnational corporations in the circulation of scientific knowledge is considered. If institutions generate, mostly scientific knowledge, trying to facilitate its free circulation, then transnational companies, contrarily, try to remove most significant and cutting-edge scientific knowledge from free circulation and its commercialization and reintroduction into an open, but now commercial, circulation in the TRIPS. However, paradoxical, the open access movement ...

  13. Towards universal access to all knowledge-Internet Archive

    Institute of Scientific and Technical Information of China (English)

    KAHLE Brewster

    2005-01-01

    Advances in computing and communications mean that we can cost-effectively store every book, sound recording,movie, software package, and public Web page ever created, and provide access to these collections via the Internet to students and adults all over the world. By mostly using existing institutions and funding sources, we can build this as well as compensate authors within the current worldwide library budget. We should take advantage of our new technologies and our open societies to make a Universal Library again, and go the next step and make all knowledge easily available to every man, woman and child around the world.

  14. Human Knowledge Resources and Interorganizational Systems

    NARCIS (Netherlands)

    M.K.M. Ibrahim (Mohammed); P.M.A. Ribbers (Piet); B.W.M. Bettonvil

    2007-01-01

    textabstractThis paper analyses how human knowledge resources affect capabilities and subsequently attainment of operational and strategic benefits. We test a conceptual model using data from two qualitative case studies and a quantitative field study. The findings indicate that human knowledge

  15. Human Knowledge Resources and Interorganizational Systems

    NARCIS (Netherlands)

    M.K.M. Ibrahim (Mohammed); P.M.A. Ribbers (Piet); B.W.M. Bettonvil

    2007-01-01

    textabstractThis paper analyses how human knowledge resources affect capabilities and subsequently attainment of operational and strategic benefits. We test a conceptual model using data from two qualitative case studies and a quantitative field study. The findings indicate that human knowledge posi

  16. VIALACTEA knowledge base homogenizing access to Milky Way data

    CERN Document Server

    Molinaro, Marco; Bandieramonte, Marilena; Becciani, Ugo; Brescia, Massimo; Cavuoti, Stefano; Costa, Alessandro; Di Giorgio, Anna M; Elia, Davide; Hajnal, Akos; Gabor, Hermann; Kacsuk, Peter; Liu, Scige J; Molinari, Sergio; Riccio, Giuseppe; Schisano, Eugenio; Sciacca, Eva; Smareglia, Riccardo; Vitello, Fabio

    2016-01-01

    The VIALACTEA project has a work package dedicated to Tools and Infrastructure and, inside it, a task for the Database and Virtual Observatory Infrastructure. This task aims at providing an infrastructure to store all the resources needed by the, more purposely, scientific work packages of the project itself. This infrastructure includes a combination of: storage facilities, relational databases and web services on top of them, and has taken, as a whole, the name of VIALACTEA Knowledge Base (VLKB). This contribution illustrates the current status of this VLKB. It details the set of data resources put together; describes the database that allows data discovery through VO inspired metadata maintenance; illustrates the discovery, cutout and access services built on top of the former two for the users to exploit the data content.

  17. VIALACTEA knowledge base homogenizing access to Milky Way data

    Science.gov (United States)

    Molinaro, Marco; Butora, Robert; Bandieramonte, Marilena; Becciani, Ugo; Brescia, Massimo; Cavuoti, Stefano; Costa, Alessandro; Di Giorgio, Anna M.; Elia, Davide; Hajnal, Akos; Gabor, Hermann; Kacsuk, Peter; Liu, Scige J.; Molinari, Sergio; Riccio, Giuseppe; Schisano, Eugenio; Sciacca, Eva; Smareglia, Riccardo; Vitello, Fabio

    2016-08-01

    The VIALACTEA project has a work package dedicated to "Tools and Infrastructure" and, inside it, a task for the "Database and Virtual Observatory Infrastructure". This task aims at providing an infrastructure to store all the resources needed by the, more purposely, scientific work packages of the project itself. This infrastructure includes a combination of: storage facilities, relational databases and web services on top of them, and has taken, as a whole, the name of VIALACTEA Knowledge Base (VLKB). This contribution illustrates the current status of this VLKB. It details the set of data resources put together; describes the database that allows data discovery through VO inspired metadata maintenance; illustrates the discovery, cutout and access services built on top of the former two for the users to exploit the data content.

  18. The accessibility of research-based knowledge for nurses in United Kingdom acute care settings.

    Science.gov (United States)

    Thompson, C; McCaughan, D; Cullum, N; Sheldon, T A; Mulhall, A; Thompson, D R

    2001-10-01

    The successful dissemination of the results of the National Health Service (NHS) research and development strategy and the development of evidence based approaches to health care rely on clinicians having access to the best available evidence; evidence fit for the purpose of reducing the uncertainties associated with clinical decisions. To reveal the accessibility of those sources of information actually used by nurses, as well as those which they say they use. Mixed method case site, using interview, observational, Q sort and documentary audit data in medical, surgical and coronary care units (CCUs) in three acute hospitals. Three perspectives on accessibility were identified: (a) the humanist--in which human sources of information were the most accessible; (b) local information for local needs--in which locally produced resources were seen as the most accessible and (c) moving towards technology--in which information technology begins to be seen as accessible. Nurses' experience in a clinical specialty is positively associated with a perception that human sources such as clinical nurse specialists, link nurses, doctors and experienced clinical colleagues are more accessible than text based sources. Clinical specialization is associated with different approaches to accessing research knowledge. Coronary care unit nurses were more likely to perceive local guidelines, protocols and on-line databases as more accessible than their counterparts in general medical and surgical wards. Only a third of text-based resources available to nurses on the wards had any explicit research base. These, and the remainder were out of date (mean age of textbooks 11 years), and authorship hard to ascertain. A strategy to increase the use of research evidence by nurses should harness the influence of clinical nurse specialists, link nurses and those engaged in practice development. These roles could act as 'conduits' through which research-based messages for practice, and information

  19. Global forces and local currents in Argentina's science policy crossroads: restricted access or open knowledge

    Directory of Open Access Journals (Sweden)

    Horacio Javier Etchichury

    2014-11-01

    Full Text Available The article describes the tensions between two competing approaches to scientific policy in Argentina. The traditional vision favors autonomous research. The neoliberal conception fosters the link between science and markets. In the past few years, a neodevelopmentalist current also tries to stress relevance of scientific research. Finally, the article describes how the Open Access movement has entered the debate. The World Bank intervention and the human rights dimension of the question are discussed in depth. The article introduces the notion of open knowledge as a guiding criterion to design a human-rights based scientific policy.

  20. Open access: a perspective from the humanities

    Directory of Open Access Journals (Sweden)

    Peter Mandler

    2014-07-01

    Full Text Available This article surveys the debates over UK public policy for open access (OA since 2012 from the perspective of scholars in the humanities. It isolates points in Research Council and REF policy that have come under criticism from the humanities community for their basis in science practice, and assesses the progress that has been made in addressing these concerns. Issues considered include ‘gold’ and ‘green’ models of OA, the role of university managers in determining where and what academics can publish, embargo periods and licensing. The author is President of the Royal Historical Society.

  1. "The architecture of access to scientific knowledge: just how badly we have messed this up"

    CERN Document Server

    CERN. Geneva

    2011-01-01

    In this talk, Professor Lessig will review the evolution of access to scientific scholarship, and evaluate the success of this system of access against a background norm of universal access.While copyright battles involving artists has gotten most of the public's attention, the real battle should be over access to knowledge, not culture. That battle we are losing.

  2. Pharmaceutical knowledge governance: a human rights perspective.

    Science.gov (United States)

    Lemmens, Trudo

    2013-01-01

    Industry control over the production and distribution of pharmaceutical safety and efficacy data has become a serious public health and health care funding concern. Various recent scandals, several involving the use of flawed representations of scientific data in the most influential medical journals, highlight the urgency of enhancing pharmaceutical knowledge governance. This paper analyzes why this is a human rights concern and what difference a human rights analysis can make. The paper first identifies the challenges associated with the current knowledge deficit. It then discusses, based on an analysis of case law, how various human rights associated interests can be invoked to support the claim that states have an obligation to actively contribute to independent knowledge governance, for example through ensuring clinical trials transparency. The paper further discusses a conceptual use of human rights, as a methodology which requires a comprehensive analysis of the different interwoven historical, economic, cultural, and social factors that contribute to the problem. Such an analysis reveals that historically grown drug regulations have, in fact, contributed directly to industry control over pharmaceutical knowledge production. This type of finding should inform needed reforms of drug regulation. The paper ends with a recommendation for a comprehensive global response to the problem of pharmaceutical knowledge governance. © 2013 American Society of Law, Medicine & Ethics, Inc.

  3. Human Resource Development in the Knowledge Economy

    DEFF Research Database (Denmark)

    Jørgensen, Sanne Lehmann

    . In this line of thinking, the aim is to propose a model for analysing the progress of knowledge improvements in developing countries as an outcome of the management of human, social and organisational capital. In this regard, the paper considers relevant practices and strategies in the context of developing...

  4. Sources of inter-firm heterogeneity in accessing knowledge-creation benefits within technology clusters

    NARCIS (Netherlands)

    Arikan, A.; Knoben, J.

    2014-01-01

    We build on recent literature to highlight the distinction between knowledge-diffusion and knowledge-creation benefits of technology clustering and argue that firms located in technology clusters will have differential access to the latter. To explain the antecedents of such differential access, we

  5. Knowledge unbound selected writings on Open Access, 2002-2011

    CERN Document Server

    Suber, Peter

    2016-01-01

    Peter Suber has been a leading advocate for open access since 2001 and has worked full time on issues of open access since 2003. As a professor of philosophy during the early days of the internet, he realized its power and potential as a medium for scholarship. As he writes now, "it was like an asteroid crash, fundamentally changing the environment, challenging dinosaurs to adapt, and challenging all of us to figure out whether we were dinosaurs." When Suber began putting his writings and course materials online for anyone to use for any purpose, he soon experienced the benefits of that wider exposure. In 2001, he started a newsletter -- the Free Online Scholarship Newsletter, which later became the SPARC Open Access Newsletter -- in which he explored the implications of open access for research and scholarship. This book offers a selection of some of Suber's most significant and influential writings on open access from 2002 to 2010. In these texts, Suber makes the case for open access to research; answers c...

  6. Human Resource Development in the Knowledge Economy

    DEFF Research Database (Denmark)

    Jørgensen, Sanne Lehmann

    This paper addresses the crucial call for upgrading to more value-added production in developing country firms in the light of increased global competition and suggests that such upgrading demands a shift in focus from investment in technology to investment in people, knowledge and learning....... In this line of thinking, the aim is to propose a model for analysing the progress of knowledge improvements in developing countries as an outcome of the management of human, social and organisational capital. In this regard, the paper considers relevant practices and strategies in the context of developing...

  7. Employees and Creativity: Social Ties and Access to Heterogeneous Knowledge

    Science.gov (United States)

    Huang, Chiung-En; Liu, Chih-Hsing Sam

    2015-01-01

    This study dealt with employee social ties, knowledge heterogeneity contacts, and the generation of creativity. Although prior studies demonstrated a relationship between network position and creativity, inadequate attention has been paid to network ties and heterogeneity knowledge contacts. This study considered the social interaction processes…

  8. Employees and Creativity: Social Ties and Access to Heterogeneous Knowledge

    Science.gov (United States)

    Huang, Chiung-En; Liu, Chih-Hsing Sam

    2015-01-01

    This study dealt with employee social ties, knowledge heterogeneity contacts, and the generation of creativity. Although prior studies demonstrated a relationship between network position and creativity, inadequate attention has been paid to network ties and heterogeneity knowledge contacts. This study considered the social interaction processes…

  9. Information Architecture and the Comic Arts: Knowledge Structure and Access

    Science.gov (United States)

    Farmer, Lesley S. J.

    2015-01-01

    This article explains information architecture, focusing on comic arts' features for representing and structuring knowledge. Then it details information design theory and information behaviors relative to this format, also noting visual literacy. Next , applications of comic arts in education are listed. With this background, several research…

  10. EVOLUTION OF KNOWLEDGE DEVELOPMENT IN HUMAN RESUSCITATION

    Directory of Open Access Journals (Sweden)

    O. Zabolotina

    2010-01-01

    Full Text Available Study of human resuscitation development history is the first step in understanding modern approaches to cardiopulmonary resuscitation. A significant increase in survival parameters is driven by accumulation of knowledge, expertise, improvement in resuscitation technologies. Development of cardiopulmonary resuscitation structure, development of recommendations approved for study and practical use, addressing these issues at the state level are accompanied with a significant reduction in mortality both at the hospital and pre-hospital levels. Key words: children, cardiopulmonary resuscitation, development stages, training of pediatricians. (Pediatric Pharmacology. – 2010; 7(3:25-27

  11. Increasing Access to Evidence-Based Practices and Knowledge and Attitudes: A Pilot Study

    Science.gov (United States)

    Leathers, Sonya J.; Strand, Tonya C.

    2013-01-01

    Objective: This pilot study examined the effect of increasing field instructors access to information about evidence-based practices (EBPs) on their level of knowledge and attitudes about EBPs. Method: Eighteen field instructors received training and access to a library with extensive online journals. Half were randomly selected to also receive a…

  12. Building a Generation Knowledge Source using Internet-Accessible Newswire

    CERN Document Server

    Radev, D R; Radev, Dragomir R.; Keown, Kathleen R. Mc

    1997-01-01

    In this paper, we describe a method for automatic creation of a knowledge source for text generation using information extraction over the Internet. We present a prototype system called PROFILE which uses a client-server architecture to extract noun-phrase descriptions of entities such as people, places, and organizations. The system serves two purposes: as an information extraction tool, it allows users to search for textual descriptions of entities; as a utility to generate functional descriptions (FD), it is used in a functional-unification based generation system. We present an evaluation of the approach and its applications to natural language generation and summarization.

  13. What Type of Knowledge Provides Valid Housing Standards Addressing Accessibility?

    DEFF Research Database (Denmark)

    Helle, Tina; Brandt, Åse; Iwarsson, Susanne

    2013-01-01

    next to domestic appliances or for enabling door closing of those using mobility devices. Therefore, in line with the findings of others, there is a need for a research-based revision of the standards (Steinfeld et al., 2010; Helle et al., 2011). Further, there is a need for a critical review...... with functional limitations and dependence on mobility devices to have access to housing design features as a means to be able to interact with the environment to perform a range of everyday activities in the dwelling. However, in a comprehensive literature review in search of scientific publications......, the environment and the activity. In line with previous research on older people’s use of mobility devices in everyday activities (Löfqvist et al., 2008), it was found that mobility devices formed part of the activity, since the mobility devices were used for transportation of e.g. a cup of coffee that was placed...

  14. Open access and knowledge sharing: reflections on the Pathfinder projects and Open Access Good Practice initiative

    Directory of Open Access Journals (Sweden)

    Hannah DeGroff

    2016-07-01

    Full Text Available The following article provides a selection of reflections from a number of higher education institutions and their staff about participation in the UK-wide Pathfinder project scheme. These nine projects (comprising 30 institutions form the core of the Jisc-funded Open Access Good Practice initiative. They have produced a wide range of outputs which endorse and encourage best practice when implementing open access across institutions. Each project has a blog where progress and outputs can be tracked. Details are listed at the end of this article.

  15. Open Access and its impact on the Knowledge Society: Latin American Case Studies Insights

    Directory of Open Access Journals (Sweden)

    María Soledad RAMÍREZ MONTOYA

    2015-04-01

    Full Text Available In a changing society, open access may represent an alternative growth and resources to the educational community, from the opportunities given to students, to teachers, researchers and administrators of educational institutions. The aim of this paper is to analyze the opportunities and challenges that gives open access to the educational community, through the presentation of a conceptual vision and practical cases in Latin America, on the issue of open educational resources, repositories, journals and open access policies –from universities and government agencies or financing– and its link to a knowledge society. The findings are presented on three key elements: opportunities, challenges and opportunities open to access the knowledge society.

  16. Towards a Reference Model for Open Access and Knowledge Sharing, Lessons from Systems Research

    CERN Document Server

    Di Maio, Paola

    2011-01-01

    The Open Access Movement has been striving to grant universal unrestricted access to the knowledge and data outputs of publicly funded research. leveraging the real time, virtually cost free publishing opportunities offered by the internet and the web. However, evidence suggests that in the systems engineering domain open access policies are not widely adopted. This paper presents the rationale, methodology and results of an evidence based inquiry that investigates the dichotomy between policy and practice in Open Access (OA) of systems engineering research in the UK, explores entangled dimensions of the problem space from a socio-technical perspective, and issues a set of recommendations, including a reference model outline for knowledge sharing in systems research

  17. Knowledge of human immunodeficiency virus post-exposure ...

    African Journals Online (AJOL)

    Knowledge of human immunodeficiency virus post-exposure prophylaxis among doctors in a Nigerian tertiary hospital. ... of PEP policy in the hospital. The level of knowledge concerning the high-risk fluid and three drugs used in PEP is high.

  18. From Information to Knowledge Online Access to Legal Information Methodologies, Trends and Perspectives

    CERN Document Server

    Biasiotti, MA

    2011-01-01

    Access to accurate legal information is of great importance. Certainty of the law, creating the conditions necessary to equality and fairness in a legal system and improving the functioning of democratic institutions, depends upon it. Citizens have a right to information about the laws which govern their conduct and governments have an obligation to enable access to the law by means of all available and practicable tools. This book presents papers delivered at the workshop 'From Information to Knowledge - Online Access to Legal Information', held in Florence, Italy, in May 2011. This workshop

  19. Liberal Education Reconsidered: Cultivating Humanity in the Knowledge Society

    Science.gov (United States)

    Hong, Eunsook

    2014-01-01

    In the knowledge society, there is a conflict between "education for profit" and "education for humanity." Education for profit is needed for students' economic survival and success in the knowledge economy. Education for humanity is needed for their existential lives worthy of human beings. This paper deals with the…

  20. Liberal Education Reconsidered: Cultivating Humanity in the Knowledge Society

    Science.gov (United States)

    Hong, Eunsook

    2014-01-01

    In the knowledge society, there is a conflict between "education for profit" and "education for humanity." Education for profit is needed for students' economic survival and success in the knowledge economy. Education for humanity is needed for their existential lives worthy of human beings. This paper deals with the…

  1. Human bocavirus: Current knowledge and future challenges

    Science.gov (United States)

    Guido, Marcello; Tumolo, Maria Rosaria; Verri, Tiziano; Romano, Alessandro; Serio, Francesca; De Giorgi, Mattia; De Donno, Antonella; Bagordo, Francesco; Zizza, Antonella

    2016-01-01

    Human bocavirus (HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate (HBoV1), namely HBoV2, HBoV3 and HBoV4, have been detected principally in human faeces. HBoVs are small non-enveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1 (NS1) and nuclear phosphoprotein (NP1) and the third the viral capsid proteins 1 and 2 (VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBoV infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzyme-linked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoVs as true pathogen or innocent bystander is also emphasized.

  2. KNOWLEDGE MANAGEMENT SYSTEM DESIGN AT HUMAN RESOURCES DIVISION

    Directory of Open Access Journals (Sweden)

    Yanti Yanti

    2009-05-01

    Full Text Available The Human Resources Division of a company is a vital division. Most of the time, they perform their work manually, and therefore creating limitations to their capacity. The knowledge contained is very important for human resources development and subsequently for developing the company. In order to manage this knowledge well, the company shall require a knowledge management system. This knowledge management system would be a solution to be used for the company to manage all knowledge contained in that particular division. Phases in designing knowledge managements starts from analyzing knowledge sources of the company, knowledge identification and definition, and determining knowledge goals. Knowledge management systems contain many functions such as collecting, recording and managing the knowledge and sharing this to all related employees easily. The company may also use knowledge management systems to share and inform employees regarding updates of information, news and/or activity regarding the employees themselves. Information from knowledge management systems may also be used by employees to monitor their performance and thereby increasing it. Knowledge management systems may also help employees in their learning activities.Keywords: knowledge management, human resources, employee

  3. Access to finance from different finance provider types: Farmer knowledge of the requirements

    Science.gov (United States)

    Meuwissen, Miranda P. M.; Karmana, Maman H.; Oude Lansink, Alfons G. J. M.

    2017-01-01

    Analysing farmer knowledge of the requirements of finance providers can provide valuable insights to policy makers about ways to improve farmers’ access to finance. This study compares farmer knowledge of the requirements to obtain finance with the actual requirements set by different finance provider types, and investigates the relation between demographic and socioeconomic factors and farmer knowledge of finance requirements. We use a structured questionnaire to collect data from a sample of finance providers and farmers in Java Island, Indonesia. We find that the most important requirements to acquire finance vary among different finance provider types. We also find that farmers generally have little knowledge of the requirements, which are important to each type of finance provider. Awareness campaigns are needed to increase farmer knowledge of the diversity of requirements among the finance provider types. PMID:28877174

  4. Access to finance from different finance provider types: Farmer knowledge of the requirements.

    Science.gov (United States)

    Wulandari, Eliana; Meuwissen, Miranda P M; Karmana, Maman H; Oude Lansink, Alfons G J M

    2017-01-01

    Analysing farmer knowledge of the requirements of finance providers can provide valuable insights to policy makers about ways to improve farmers' access to finance. This study compares farmer knowledge of the requirements to obtain finance with the actual requirements set by different finance provider types, and investigates the relation between demographic and socioeconomic factors and farmer knowledge of finance requirements. We use a structured questionnaire to collect data from a sample of finance providers and farmers in Java Island, Indonesia. We find that the most important requirements to acquire finance vary among different finance provider types. We also find that farmers generally have little knowledge of the requirements, which are important to each type of finance provider. Awareness campaigns are needed to increase farmer knowledge of the diversity of requirements among the finance provider types.

  5. Conscious knowledge of learning: accessing learning strategies in a final year high school biology class

    Science.gov (United States)

    Conner, Lindsey; Gunstone, Richard

    2004-12-01

    This paper reports on a qualitative case study investigation of the knowledge and use of learning strategies by 16 students in a final year high school biology class to expand their conscious knowledge of learning. Students were provided with opportunities to engage in purposeful inquiry into the biological, social and ethical aspects of cancer. A constructivist approach was implemented to access prior content and procedural knowledge in various ways. Students were encouraged to develop evaluation of their learning skills independently through activities that promoted metacognition. Those students who planned and monitored their work produced essays of higher quality. The value and difficulties of promoting metacognitive approaches in this context are discussed, as well as the idea that metacognitive processes are difficult to research, because they have to be conscious in order to be identified by the learner, thereby making them accessible to the researcher.

  6. Human rights and immigrants’ access to care

    Directory of Open Access Journals (Sweden)

    Wendy Parmet

    2013-11-01

    Full Text Available Although the human right to health is well established under international law, many states limit non-citizens’ participation in public insurance programs. In the United States, immigrants face especially high barriers due to the lack of recognition of a broad right to health as well as federal statutes restricting many immigrants’ eligibility to federally-funded insurance. High rates of uninsurance among immigrants have a detrimental effect on their health, as well as on the health of citizens who live in their communities. Finch vs. Commonwealth Health Insurance Connector, a recent case decided by the Supreme Judicial Court of Massachusetts, recognized the rights of legal immigrants in Massachusetts to state-supported health care, and demonstrates the importance of insuring immigrants in broadly-based, rather than immigrant-specific, programs.

  7. Co-op students' access to shared knowledge in science-rich workplaces

    Science.gov (United States)

    Munby, Hugh; Taylor, Jennifer; Chin, Peter; Hutchinson, Nancy L.

    2007-01-01

    Wenger's (1998) concepts community of practice, brokering, and transfer explain the challenges co-operative (co-op) education students face in relating the knowledge learned in school with what they learn while participating as members of a workplace. The research for this paper is set within the contexts of the knowledge economy and increased collaboration in the workplace. The paper draws on several qualitative studies of work-based education to examine the similarities and differences between learning in the workplace and learning in school, with a focus on science education and science-rich workplaces. Barriers to connecting school knowledge and workplace knowledge include the nature of science (its purpose, accountability, and substance), the structure of knowledge in each setting, the form content knowledge takes, the sequence that the curriculum is presented in, and the gatekeeping that occurs when knowledge is accessed. The paper addresses implications for interventions in school and the workplace, with attention to the transition from school to work, and concludes by pointing to profound obstacles to connecting school knowledge with workplace knowledge.

  8. HUMAN CAPITAL MANAGEMENT IN A KNOWLEDGE ECONOMY ...

    African Journals Online (AJOL)

    approach in Scientific Research Centers within knowledge based economy. ... assets, and external structure such as brands, reputation and relationships .... dates back to Mincer's article in 1958. Then Schultz ..... BIBLIOGRAPHY. Afiouni F ...

  9. Human Resources Management Value in Knowledge-Based Society

    OpenAIRE

    Lobanova, Liudmila

    2009-01-01

    While building knowledge-based society and economy, particular importance in human resources management falls on the value of human resources and management expertise. The article analyses the features of human resources management competences in terms of completing human resources management functions in practice with a view to advantages of human resources management approaches compared with traditional approaches to human resources management. Upon research on personnel management function...

  10. Public access to community documents: a fundamental human right?

    Directory of Open Access Journals (Sweden)

    Roy W. Davis

    1999-07-01

    Full Text Available There is a marked difference between the culture of open government in some Member States, particularly Sweden, and the culture of secrecy in Britain. Recent calls for a uniform interpretation of the law regarding public access to documents held by the Community Institutions seem to suggest that a Swedish-style right of access should be adopted at EU level, on the grounds that public access to government-held information is a fundamental human right. To date, however, it seems that insufficient arguments have been advanced in order to justify this particular claim. Notable constitutional lawyers remain sceptical, as do some Member State governments. Furthermore, in the absence of a convincing philosophical justification for the claim, a situation may be created in which certain people are said to enjoy a fundamental human right, not because they are human beings, but by virtue of their status as citizens or residents of an EU Member State. This appears to be counter-intuitive, if it is accepted that fundamental human rights should be enjoyed by all and should therefore be justified on the basis of universally-shared fundamental values. It therefore seems that further explanation of the importance of public access to documents is required, and further justification of the claim that this is, or should be regarded as, a fundamental human right.

  11. Origins and early development of human body knowledge.

    Science.gov (United States)

    Slaughter, Virginia; Heron, Michelle

    2004-01-01

    As a knowable object, the human body is highly complex. Evidence from several converging lines of research, including psychological studies, neuroimaging and clinical neuropsychology, indicates that human body knowledge is widely distributed in the adult brain, and is instantiated in at least three partially independent levels of representation. Sensorimotor body knowledge is responsible for on-line control and movement of one's own body and may also contribute to the perception of others' moving bodies; visuo-spatial body knowledge specifies detailed structural descriptions of the spatial attributes of the human body; and lexical-semantic body knowledge contains language-based knowledge about the human body. In the first chapter of this Monograph, we outline the evidence for these three hypothesized levels of human body knowledge, then review relevant literature on infants' and young children's human body knowledge in terms of the three-level framework. In Chapters II and III, we report two complimentary series of studies that specifically investigate the emergence of visuo-spatial body knowledge in infancy. Our technique is to compare infants'responses to typical and scrambled human bodies, in order to evaluate when and how infants acquire knowledge about the canonical spatial layout of the human body. Data from a series of visual habituation studies indicate that infants first discriminate scrambled from typical human body picture sat 15 to 18 months of age. Data from object examination studies similarly indicate that infants are sensitive to violations of three-dimensional human body stimuli starting at 15-18 months of age. The overall pattern of data supports several conclusions about the early development of human body knowledge: (a) detailed visuo-spatial knowledge about the human body is first evident in the second year of life, (b) visuo-spatial knowledge of human faces and human bodies are at least partially independent in infancy and (c) infants' initial

  12. The challenges for human factors in knowledge work

    DEFF Research Database (Denmark)

    Ipsen, Christine; Møller, Niels; Jensen, Per Langaa

    2011-01-01

    The development towards a service and knowledge intensive economy arise new challenges for ergonomics and human factors. Knowledge on work within mass service production exists, but the challenges within knowledge work have still to be addressed. The focus of this paper is on some of the challeng...... with the demands of the knowledge intensive work when KPI’s are central management tools. Especially handling the balance between high motivation and enthusiasm and burn out will be addressed....

  13. CRESST Human Performance Knowledge Mapping System

    Science.gov (United States)

    2002-12-01

    team processes and team outcomes. Computers in Human Behavior , 15, 463-494. 0 Herl, H. E. (1995). Construct validation of an approach to modeling...system to measure content understanding. Computers in Human Behavior , 15, 315-334. Johnson, R.F. (2001). Statistical measures of marksmanship (ARI...problem-solving. Computers in Human Behavior , 15, 403-418. West, C. D., Pomeroy, J. R., Park, J. K., Gerstenberger, E. A., & Sandoval, J. (2000

  14. Factors influencing access to agricultural knowledge: The case of smallholder rice farmers in the Kilombero district of Tanzania

    Directory of Open Access Journals (Sweden)

    Wulystan P. Mtega

    2016-04-01

    Full Text Available Background: Access to agricultural knowledge is important in transforming livelihoods of those relying on agriculture for a living and in enhancing food security. This access to agricultural knowledge is influenced by infrastructure needed for information dissemination. However, information infrastructure is not uniformly distributed within and between countries. It is because of this that some of the farming communities are information rich while others are information poor. In Tanzania, the agricultural sector is characterised by poor research-extension-farmers linkage and inaccessibility of agricultural knowledge at farm levelObjective: The study investigated the factors influencing access to agricultural knowledge among smallholder rice farmers in the Kilombero district of Tanzania. Specifically, the study identified categories of agricultural knowledge needed by farmers, determined how farmers access agricultural knowledge, and assessed the factors limiting the accessibility of agricultural knowledge among rice farmers in the Kilombero district.Method: Quantitative data were collected via semi-structured questionnaires administered face-to-face with rice farmers, community leaders, and agricultural agents in four villages at the Kilombero district of the Morogoro region in Tanzania.Results: The key finding indicates that farmers accessed and used agricultural knowledge in undertaking agricultural activities. It was further revealed that the level of acquisition of agricultural knowledge increased with an increase in age. Farmers needed agricultural knowledge on land preparation, seed selection, and rice planting, while few acquired knowledge on agricultural markets. Among the agricultural knowledge sources used, demonstration plots and agricultural extension agents were found to be used by the majority of the farmers. It was also found that a limited number of demonstration plots, late delivery of information services, a limited number of

  15. User needs in television archive access:Acquiring knowledge necessary for system design

    OpenAIRE

    2009-01-01

    This paper presents a methodical approach for generating deep knowledge about users, as a prerequisite for design and construction of digital information access to cultural heritage information objects. We exemplify this methodical approach by reporting on an explorative study of information need characteristics in a television broadcast context. The methodical approach is inspired by naturalistic research, and our main data is nine in-depth interviews conducted with scholars and students wit...

  16. Medical students' knowledge, abilities and access characteristics to the internet at a peruvian university

    OpenAIRE

    Horna, Pedro; Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia; Sociedad Científica de Estudiantes de Medicina Cayetano Heredia – SOCEMCH; Curioso, Walter; Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia; Sociedad Científica de Estudiantes de Medicina Cayetano Heredia – SOCEMCH; Guillén, Carlos; Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia; Sociedad Científica de Estudiantes de Medicina Cayetano Heredia – SOCEMCH; Torres, Carla; Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia; Sociedad Científica de Estudiantes de Medicina Cayetano Heredia – SOCEMCH; Kawano, Jorge; Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia; Sociedad Científica de Estudiantes de Medicina Cayetano Heredia – SOCEMCH

    2013-01-01

    Objectives: To study the knowledge abilities and access characteristics to the Internet in undergraduate medical students from a Peruvian University. Methods: Development and application of a questionnaire to medical students, report of the results and nested case-control analysis of data to identify variables related to the ability to surf the Internet. Results: The students enter the Internet mainly from home. The most visited websites were those from web mail services and entertainment sit...

  17. Achieving Access to Knowledge through E-Learning: A Case Study

    Directory of Open Access Journals (Sweden)

    Christian A. Bolu

    2012-10-01

    Full Text Available More and more scholars are turning to the Internet to find scientific information and academic institutions are devoting more and more resources to improving their presence on the web.E-learning programs and open access initiatives allow knowledge of these institutions to spread beyond physical boundaries. The Web can hence be used as a way to attract students, scholars and funding from other places, spreading the prestige of these educational institutions all over the world. This has provoked competition between universities to achieve an advantageous visibility on the Web and to improve their position in search engine results.This paper examines ongoing e-learning effort globally to enhance access to knowledge. In particular the role of University of Nigeria is playing in the promotion of access to knowledge is discussed. In line with their Information and Communication Technology Programme, the University has created an Internet repository of over 20,000 documents such as theses, journals articles and academic publications as well as a vibrant e-learning portal.

  18. [Right of access to the assisted human reproduction: bioethics discussions].

    Science.gov (United States)

    Medeiros, Luciana Soares de; Verdi, Marta Inez Machado

    2010-10-01

    The objective of this study is to evaluate how is configured the right of access to the assisted human reproduction service (AHRS). It was developed through documentary research in official sources of the Brazilian Federal Government. From the criteria of the analysis of content were analyzed: 1 government directive and 6 projects of law, divided in 3 thematic areas (access to what?; access to whom?; and conditions and criteria of access), revealing nucleus of meaning that had been explored in this research. This revealed that the right of access in official documents is exclusive, and morally induced by a professional category and its arbitrariness. The joint of these nucleus of meaning with the everyday bioethics was of extreme relevance to deal with the different kinds of family that are being legitimated through these proposals of regulation, as well as the ethical questions intrinsic to the formulation of these texts, which remit us to the idea of traditional family, model not hegemonic anymore in our society, and social and legally surpassed by new familiar conceptions that also demand visibility and legitimacy from the State. The study intends to be one more possibility of reflection about the questions that involve the right of access to the AHRS from the everyday bioethics issues.

  19. Parametric Grid Information in the DOE Knowledge Base: Data Preparation, Storage and Access.

    Energy Technology Data Exchange (ETDEWEB)

    Hipp, J. R.; Young, C. J.; Moore, S. G.; Shepherd, E. R.; Schultz, C. A.; Myers, S. C.

    1999-10-01

    The parametric grid capability of the Knowledge Base provides an efficient, robust way to store and access interpolatable information which is needed to monitor the Comprehensive Nuclear Test Ban Treaty. To meet both the accuracy and performance requirements of operational monitoring systems, we use a new approach which combines the error estimation of kriging with the speed and robustness of Natural Neighbor Interpolation (NNI). The method involves three basic steps: data preparation (DP), data storage (DS), and data access (DA). The goal of data preparation is to process a set of raw data points to produce a sufficient basis for accurate NNI of value and error estimates in the Data Access step. This basis includes a set of nodes and their connectedness, collectively known as a tessellation, and the corresponding values and errors that map to each node, which we call surfaces. In many cases, the raw data point distribution is not sufficiently dense to guarantee accurate error estimates from the NNI, so the original data set must be densified using a newly developed interpolation technique known as Modified Bayesian Kriging. Once appropriate kriging parameters have been determined by variogram analysis, the optimum basis for NNI is determined in a process we call mesh refinement, which involves iterative kriging, new node insertion, and Delauny triangle smoothing. The process terminates when an NNI basis has been calculated which will fit the kriged values within a specified tolerance. In the data storage step, the tessellations and surfaces are stored in the Knowledge Base, currently in a binary flatfile format but perhaps in the future in a spatially-indexed database. Finally, in the data access step, a client application makes a request for an interpolated value, which triggers a data fetch from the Knowledge Base through the libKBI interface, a walking triangle search for the containing triangle, and finally the NNI interpolation.

  20. Parametric Grid Information in the DOE Knowledge Base: Data Preparation, Storage, and Access

    Energy Technology Data Exchange (ETDEWEB)

    HIPP,JAMES R.; MOORE,SUSAN G.; MYERS,STEPHEN C.; SCHULTZ,CRAIG A.; SHEPHERD,ELLEN; YOUNG,CHRISTOPHER J.

    1999-10-01

    The parametric grid capability of the Knowledge Base provides an efficient, robust way to store and access interpolatable information which is needed to monitor the Comprehensive Nuclear Test Ban Treaty. To meet both the accuracy and performance requirements of operational monitoring systems, we use a new approach which combines the error estimation of kriging with the speed and robustness of Natural Neighbor Interpolation (NNI). The method involves three basic steps: data preparation (DP), data storage (DS), and data access (DA). The goal of data preparation is to process a set of raw data points to produce a sufficient basis for accurate NNI of value and error estimates in the Data Access step. This basis includes a set of nodes and their connectedness, collectively known as a tessellation, and the corresponding values and errors that map to each node, which we call surfaces. In many cases, the raw data point distribution is not sufficiently dense to guarantee accurate error estimates from the NNI, so the original data set must be densified using a newly developed interpolation technique known as Modified Bayesian Kriging. Once appropriate kriging parameters have been determined by variogram analysis, the optimum basis for NNI is determined in a process they call mesh refinement, which involves iterative kriging, new node insertion, and Delauny triangle smoothing. The process terminates when an NNI basis has been calculated which will fir the kriged values within a specified tolerance. In the data storage step, the tessellations and surfaces are stored in the Knowledge Base, currently in a binary flatfile format but perhaps in the future in a spatially-indexed database. Finally, in the data access step, a client application makes a request for an interpolated value, which triggers a data fetch from the Knowledge Base through the libKBI interface, a walking triangle search for the containing triangle, and finally the NNI interpolation.

  1. Disciplinary knowledge production and interdisciplinary humanities

    DEFF Research Database (Denmark)

    Pedersen, David Budtz; Stjernfelt, Frederik; Emmeche, Claus

    2016-01-01

    to include the social sciences and humanities research in interdisciplinary collaboration. In European research and innovation initiatives, science, technology and innovation can no longer be seen in isolation from wider cultural, societal and ethical aspects. For instance, the shift to a green sustainable...... economy needs to include combined efforts in developing new technologies and at the same time creating new models of democracy, engagement, and sustainable behaviour, which draw on a range of interdisciplinary competences. Special challenges such as the role reserved for humanities and how to integrate...

  2. EVALUATING HUMAN CAPITAL IN A KNOWLEDGE – BASED APPROACH

    Directory of Open Access Journals (Sweden)

    Emanoil MUSCALU

    2014-04-01

    Full Text Available The widespread enthusiasm for a knowledge-based approach to understanding the nature of a business and the possible basis for sustained competitive advantage have renewed interest in human capital evaluation or measurement. While many attempts have been made to develop methods for measuring intellectual capital, none have been widely adopted in the business world. In the knowledge-based organizations, and generally, in the information society, human capital is recognized as the fundamental factor of overall progress, and experts agree that long-term investment in human capital has strong drive-propagation effects at the individual, organizational, national and global level. In this paper, we consider that a knowledge-based approach can offer new possibilities and answers to illustrate the importance of evaluation the human capital and knowledge assets by consistently generating added value in the business world.

  3. BioSYNTHESIS: access to a knowledge network of health sciences databases.

    Science.gov (United States)

    Broering, N C; Hylton, J S; Guttmann, R; Eskridge, D

    1991-04-01

    Users of the IAIMS Knowledge Network at the Georgetown University Medical Center have access to multiple in-house and external databases from a single point of entry through BioSYNTHESIS. The IAIMS project has developed a rich environment of biomedical information resources that represent a medical decision support system for campus physicians and students. The BioSYNTHESIS system is an information navigator that provides transparent access to a Knowledge Network of over a dozen databases. These multiple health sciences databases consist of bibliographic, informational, diagnostic, and research systems which reside on diverse computers such as DEC VAXs, SUN 490, AT&T 3B2s, Macintoshes, IBM PC/PS2s and the AT&T ISN and SYTEK network systems. Ethernet and TCP/IP protocols are used in the network architecture. BioSYNTHESIS also provides network links to the other campus libraries and to external institutions. As additional knowledge resources and technological advances have become available. BioSYNTHESIS has evolved from a two phase to a three phase program. Major components of the system including recent achievements and future plans are described.

  4. Retrospective of Open Access Repositories and Trends in the Socialization of Knowledge

    Directory of Open Access Journals (Sweden)

    Silvia Irene Adame Rodríguez

    2013-08-01

    Full Text Available While searching for information on the Web is an everyday activity, finding free, reliable and quality information is a challenge, hence the interest in sharing part of a research project about repositories. The aim of this documentary research study is to present an overview of open access digital repositories and some trends in the socialization of knowledge produced by institutions of higher education, which in some way already mark a path toward a culture of sharing and reusing scientific, academic and cultural information for the benefit of the academic community and the general public.

  5. Open access to large scale datasets is needed to translate knowledge of cancer heterogeneity into better patient outcomes.

    Directory of Open Access Journals (Sweden)

    Andrew H Beck

    2015-02-01

    Full Text Available In this guest editorial, Andrew Beck discusses the importance of open access to big data for translating knowledge of cancer heterogeneity into better outcomes for cancer patients.

  6. The accessible chromatin landscape of the human genome.

    Science.gov (United States)

    Thurman, Robert E; Rynes, Eric; Humbert, Richard; Vierstra, Jeff; Maurano, Matthew T; Haugen, Eric; Sheffield, Nathan C; Stergachis, Andrew B; Wang, Hao; Vernot, Benjamin; Garg, Kavita; John, Sam; Sandstrom, Richard; Bates, Daniel; Boatman, Lisa; Canfield, Theresa K; Diegel, Morgan; Dunn, Douglas; Ebersol, Abigail K; Frum, Tristan; Giste, Erika; Johnson, Audra K; Johnson, Ericka M; Kutyavin, Tanya; Lajoie, Bryan; Lee, Bum-Kyu; Lee, Kristen; London, Darin; Lotakis, Dimitra; Neph, Shane; Neri, Fidencio; Nguyen, Eric D; Qu, Hongzhu; Reynolds, Alex P; Roach, Vaughn; Safi, Alexias; Sanchez, Minerva E; Sanyal, Amartya; Shafer, Anthony; Simon, Jeremy M; Song, Lingyun; Vong, Shinny; Weaver, Molly; Yan, Yongqi; Zhang, Zhancheng; Zhang, Zhuzhu; Lenhard, Boris; Tewari, Muneesh; Dorschner, Michael O; Hansen, R Scott; Navas, Patrick A; Stamatoyannopoulos, George; Iyer, Vishwanath R; Lieb, Jason D; Sunyaev, Shamil R; Akey, Joshua M; Sabo, Peter J; Kaul, Rajinder; Furey, Terrence S; Dekker, Job; Crawford, Gregory E; Stamatoyannopoulos, John A

    2012-09-06

    DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions. Here we present the first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types. We identify ∼2.9 million DHSs that encompass virtually all known experimentally validated cis-regulatory sequences and expose a vast trove of novel elements, most with highly cell-selective regulation. Annotating these elements using ENCODE data reveals novel relationships between chromatin accessibility, transcription, DNA methylation and regulatory factor occupancy patterns. We connect ∼580,000 distal DHSs with their target promoters, revealing systematic pairing of different classes of distal DHSs and specific promoter types. Patterning of chromatin accessibility at many regulatory regions is organized with dozens to hundreds of co-activated elements, and the transcellular DNase I sensitivity pattern at a given region can predict cell-type-specific functional behaviours. The DHS landscape shows signatures of recent functional evolutionary constraint. However, the DHS compartment in pluripotent and immortalized cells exhibits higher mutation rates than that in highly differentiated cells, exposing an unexpected link between chromatin accessibility, proliferative potential and patterns of human variation.

  7. The challenges for human factors in knowledge work

    DEFF Research Database (Denmark)

    Ipsen, Christine; Møller, Niels; Jensen, Per Langaa

    2011-01-01

    The development towards a service and knowledge intensive economy arise new challenges for ergonomics and human factors. Knowledge on work within mass service production exists, but the challenges within knowledge work have still to be addressed. The focus of this paper is on some of the challeng...... with the demands of the knowledge intensive work when KPI’s are central management tools. Especially handling the balance between high motivation and enthusiasm and burn out will be addressed.......The development towards a service and knowledge intensive economy arise new challenges for ergonomics and human factors. Knowledge on work within mass service production exists, but the challenges within knowledge work have still to be addressed. The focus of this paper is on some of the challenges...... in knowledge intensive work to establish productive and satisfying jobs by a case study of our own place of work: a university department. Testimonials from a young associate professor, a first line manager and the department manager lead us to identify some of the major challenges for ergonomics to comply...

  8. Role of Human Knowledge and Communication on Operational Benefits Gained from Six Sigma

    Directory of Open Access Journals (Sweden)

    Jorge L. García-Alcaraz

    2017-09-01

    Full Text Available Six Sigma (SS is a production philosophy focused on human experiences and knowledge, aimed to minimize defects of products and services. The appropriate implementation of SS requires an education process, reliable data analysis, efficient didactic material, statistical techniques and human knowledge to improve communication and operational benefits. In this article, we present a structural equation model integrating those aspects as latent variables and relating them with ten hypotheses. Data for hypothesis validation were gathered among 301 manufacturing companies, and assessed using partial least squares (PLS to estimate direct, indirect, and total effects. As results, we found that access to reliable information, trusted analysis and knowledgeable management are crucial for SS implementation at the problem definition stage. Likewise, to execute and control SS projects, it is important to be trained in statistical techniques through clear didactic materials.

  9. Knowledge environments representing molecular entities for the virtual physiological human.

    Science.gov (United States)

    Hofmann-Apitius, Martin; Fluck, Juliane; Furlong, Laura; Fornes, Oriol; Kolárik, Corinna; Hanser, Susanne; Boeker, Martin; Schulz, Stefan; Sanz, Ferran; Klinger, Roman; Mevissen, Theo; Gattermayer, Tobias; Oliva, Baldo; Friedrich, Christoph M

    2008-09-13

    In essence, the virtual physiological human (VPH) is a multiscale representation of human physiology spanning from the molecular level via cellular processes and multicellular organization of tissues to complex organ function. The different scales of the VPH deal with different entities, relationships and processes, and in consequence the models used to describe and simulate biological functions vary significantly. Here, we describe methods and strategies to generate knowledge environments representing molecular entities that can be used for modelling the molecular scale of the VPH. Our strategy to generate knowledge environments representing molecular entities is based on the combination of information extraction from scientific text and the integration of information from biomolecular databases. We introduce @neuLink, a first prototype of an automatically generated, disease-specific knowledge environment combining biomolecular, chemical, genetic and medical information. Finally, we provide a perspective for the future implementation and use of knowledge environments representing molecular entities for the VPH.

  10. Knowledge machines digital transformations of the sciences and humanities

    CERN Document Server

    Meyer, Eric T

    2015-01-01

    In Knowledge Machines, Eric Meyer and Ralph Schroeder argue that digital technologies have fundamentally changed research practices in the sciences, social sciences, and humanities. Meyer and Schroeder show that digital tools and data, used collectively and in distributed mode -- which they term e-research -- have transformed not just the consumption of knowledge but also the production of knowledge. Digital technologies for research are reshaping how knowledge advances in disciplines that range from physics to literary analysis. Meyer and Schroeder map the rise of digital research and offer case studies from many fields, including biomedicine, social science uses of the Web, astronomy, and large-scale textual analysis in the humanities. They consider such topics as the challenges of sharing research data and of big data approaches, disciplinary differences and new forms of interdisciplinary collaboration, the shifting boundaries between researchers and their publics, and the ways that digital tools promote o...

  11. The impact of mobile phones on knowledge access and transfer of small-scale horticultural farmers in Tanzania

    Directory of Open Access Journals (Sweden)

    Krone, Madlen

    2014-09-01

    Full Text Available Agriculture is the main economic activity in Tanzania and the country´s largest employer, providing livelihood for at least 80 % of the economically active population. Many studies have identified key challenges facing the sector for Africa in general – among these lack of access to knowledge. For agricultural producers, access to knowledge is important for an improved productivity and competitiveness. The fast diffusion of information and communication technologies (ICT such as mobile phones across Africa in the last years has resulted in an improved access and transfer of agricultural knowledge. Studies have shown that rural actors like farmers in remote areas even use mobile phones for their farming business. Based on qualitative interviews in the Mwanza Region in northwestern Tanzania, this study aims to identify and categorise the different types of knowledge which are transferred via mobile phones. Our results show that mobile phones enlarge the ability of farmers to access business-relevant knowledge at an increasing spatial scale. However, the effects of the use depend on the type of knowledge and other factors. The results add to existing studies by deepening the understanding of the benefits of ICT on knowledge access and transfer for the context of rural small-scale framers in Tanzania.

  12. Planetary Protection Knowledge Gaps for Human Extraterrestrial Missions: Workshop Report

    Science.gov (United States)

    Race, Margaret S. (Editor); Johnson, James E. (Editor); Spry, James A. (Editor); Siegel, Bette; Conley, Catharine A.

    2015-01-01

    This report on Planetary Protection Knowledge Gaps for Human Extraterrestrial Missions summarizes the presentations, deliberations and findings of a workshop at NASA Ames Research Center, March 24-26, 2015, which was attended by more than 100 participants representing a diverse mix of science, engineering, technology, and policy areas. The main objective of the three-day workshop was to identify specific knowledge gaps that need to be addressed to make incremental progress towards the development of NASA Procedural Requirements (NPRs) for Planetary Protection during human missions to Mars.

  13. Knowledge exchange:A strategy for open access success at The University of Hong Kong

    Institute of Scientific and Technical Information of China (English)

    David; T; PALMER

    2011-01-01

    The University of Hong Kong’s statement on vision now has three themes:1) Research, 2) teaching & learning, and 3) knowledge exchange(KE). KE emphasizes HKU’s desire to interact with its community for a mutual benefit. A new five-year strategic plan(2009-2014) sets out operational priorities and key indicators to enable knowledge exchange at HKU. Chief among these is the establishment of an exchange hub to make HKU researchers and their research products highly visible. The institutional repository of HKU, the HKU Scholars Hub, developed by its University Libraries, has become this KE exchange hub. Now the Hub includes HKU ResearcherPages, featuring the accomplishments of each HKU professoriate staff. HKU’s policy on knowledge exchange and the HKU ResearcherPages have increased the incentive for faculties, departments, and authors to place more items in open access(OA). This paper will discuss what KE is, the benefits it can bring to the university and its reputation, and how it can increase OA deposit.

  14. Knowledge of HIV-related disabilities and challenges in accessing care: Qualitative research from Zimbabwe

    Science.gov (United States)

    Zuurmond, Maria; Ferrand, Rashida; Kuper, Hannah

    2017-01-01

    Introduction While the rapid expansion in antiretroviral therapy access in low and middle income countries has resulted in dramatic declines in mortality rates, many people living with HIV face new or worsening experiences of disability. As nearly 1 in 20 adults are living with HIV in sub-Saharan Africa–many of whom are likely to develop disabling sequelae from long-term infection, co-morbidities and side effects of their treatment–understanding the availability and accessibility of services to address HIV-related disabilities is of vital importance. The aim of this study thus is to explore knowledge of HIV-related disabilities amongst stakeholders working in the fields of HIV and disability and factors impacting uptake and provision of interventions for preventing, treating or managing HIV-related disabilities. Methods In-depth, semi-structured interviews were conducted with ten stakeholders based in Harare, Zimbabwe, who were working in the fields of either disability or HIV. Stakeholders were identified through a priori stakeholder analysis. Thematic Analysis, complemented by constant comparison as described in Grounded Theory, was used to analyse findings. Results All key informants reported some level of knowledge of HIV-related disability, mostly from observations made in their line of work. However, they reported no interventions or policies were in place specifically to address HIV-related disability. While referrals between HIV and rehabilitation providers were not uncommon, no formal mechanisms had been established for collaborating on prevention, identification and management. Additional barriers to accessing and providing services to address HIV-related disabilities included: the availability of resources, including trained professionals, supplies and equipment in both the HIV and rehabilitation sectors; lack of disability-inclusive adaptations, particularly in HIV services; heavy centralization of available services in urban areas, without

  15. Access to pain treatment as a human right

    Directory of Open Access Journals (Sweden)

    Amon Joseph J

    2010-01-01

    Full Text Available Abstract Background Almost five decades ago, governments around the world adopted the 1961 Single Convention on Narcotic Drugs which, in addition to addressing the control of illicit narcotics, obligated countries to work towards universal access to the narcotic drugs necessary to alleviate pain and suffering. Yet, despite the existence of inexpensive and effective pain relief medicines, tens of millions of people around the world continue to suffer from moderate to severe pain each year without treatment. Discussion Significant barriers to effective pain treatment include: the failure of many governments to put in place functioning drug supply systems; the failure to enact policies on pain treatment and palliative care; poor training of healthcare workers; the existence of unnecessarily restrictive drug control regulations and practices; fear among healthcare workers of legal sanctions for legitimate medical practice; and the inflated cost of pain treatment. These barriers can be understood not only as a failure to provide essential medicines and relieve suffering but also as human rights abuses. Summary According to international human rights law, countries have to provide pain treatment medications as part of their core obligations under the right to health; failure to take reasonable steps to ensure that people who suffer pain have access to adequate pain treatment may result in the violation of the obligation to protect against cruel, inhuman and degrading treatment.

  16. Modular knowledge systems accelerate human migration in asymmetric random environments.

    Science.gov (United States)

    Wang, Dong; Deem, Michael W

    2016-12-01

    Migration is a key mechanism for expansion of communities. In spatially heterogeneous environments, rapidly gaining knowledge about the local environment is key to the evolutionary success of a migrating population. For historical human migration, environmental heterogeneity was naturally asymmetric in the north-south (NS) and east-west (EW) directions. We here consider the human migration process in the Americas, modelled as random, asymmetric, modularly correlated environments. Knowledge about the environments determines the fitness of each individual. We present a phase diagram for asymmetry of migration as a function of carrying capacity and fitness threshold. We find that the speed of migration is proportional to the inverse complement of the spatial environmental gradient, and in particular, we find that NS migration rates are lower than EW migration rates when the environmental gradient is higher in the NS direction. Communication of knowledge between individuals can help to spread beneficial knowledge within the population. The speed of migration increases when communication transmits pieces of knowledge that contribute in a modular way to the fitness of individuals. The results for the dependence of migration rate on asymmetry and modularity are consistent with existing archaeological observations. The results for asymmetry of genetic divergence are consistent with patterns of human gene flow. © 2016 The Author(s).

  17. Network Based Educational Environment How Libraries and Librarians Become Organizers of Knowledge Access and Resources

    CERN Document Server

    Pettenati, M C; Pettenati, Corrado

    2000-01-01

    In this paper we will highlight some important issues which will influence the redefinition of roles and duties of libraries and librarians in a networked based educational environment. Although librarians will also keep their traditional roles of faculty support services as well as reference service and research assistance, we identify the participation in the instructional design process, the support in the evaluation, development and use of a proper authoring system and the customization of information access, as being the domains where libraries and librarians should mainly involve themselves in the next future and make profit of their expertise in information and knowledge organization in order to properly and effectively support the institutions in the use of Information Technology in education.

  18. Increasing Parental Knowledge Related to the Human Papillomavirus (HPV) Vaccine.

    Science.gov (United States)

    Cipriano, Joseph J; Scoloveno, Robert; Kelly, Angela

    2017-08-16

    The purposes of this study were to evaluate parental attitudes toward general vaccination protocols and increase parental knowledge of the human papilloma virus (HPV) vaccine. A nonprobability convenience sample (N = 75) using a pre-/postintervention study design was conducted in a pediatric office in southern New Jersey. The Parental Attitudes Module measured the general disposition toward having children receive any type of vaccine. The HPV Knowledge Survey was a second tool used to specifically measures knowledge of the HPV vaccine. A self-directed computer-based learning was part of the educational intervention. A paired t test showed that HPV Knowledge Survey postintervention scores were significantly higher than HPV Knowledge Survey preintervention scores (t = -10.585, p < .001). The Parental Attitudes Module and the HPV Knowledge Survey pretest showed a positive moderate relationship (rs = .552, p < .001). In the 10 years since the HPV vaccine has been on the market, there is a continued need to increase parental knowledge about the HPV vaccine to close the gap on vaccine nonadherence. A self-directed, computer-based learning tablet appears to be an effective tool to educate parents or legal guardians about the purpose, efficacy, and safety of the HPV vaccine. Copyright © 2017 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

  19. Reducing health disparities by removing cost, access, and knowledge barriers.

    Science.gov (United States)

    Goodman, Melody; Onwumere, Ojiugo; Milam, Laurel; Peipert, Jeffrey F

    2017-04-01

    While the rate of unintended pregnancy has declined in the United States in recent years, unintended pregnancy among teens in the United States is the highest among industrialized nations, and disproportionately affects minority teens. Our objective of this secondary analysis was to estimate the risk of unintended pregnancy for both Black and White teens age 15-19 years when barriers to access, cost, and knowledge are removed. Our hypothesis was that the Black-White disparities would be reduced when access, education, and cost barriers are removed. We performed an analysis of the Contraceptive CHOICE Project database. CHOICE is a longitudinal cohort study of 9256 sexually active girls and women ages 14-45 years in the St Louis, MO, region from 2007 through 2013. Two measures of disparities were used to analyze teenage pregnancy rates and pregnancy risk from 2008 through 2013 among teens ages 15-19 years. These rates were then compared to the rates of pregnancy among all sexually active teens in the United States during the years 2008, 2009, 2010, and 2011. We estimated an absolute measure (rate difference) and a relative measure (rate ratio) to examine Black-White disparities in the rates of unintended pregnancy. While national rates of unintended pregnancy are decreasing, racial disparities in these rates persist. The Black-White rate difference dropped from 158.5 per 1000 in 2008 to 120.1 per 1000 in 2011; however, the relative ratio disparity decreased only from 2.6-2.5, suggesting that Black sexually active teens in the United States have 2.5 times the rate of unintended pregnancy as White teenagers. In the CHOICE Project, there was a decreasing trend in racial disparities in unintended pregnancy rates among sexually active teens (age 15-19 years): 2008 through 2009 (rate difference, 18.2; rate ratio, 3.7), 2010 through 2011 (rate difference, 4.3; rate ratio, 1.2), and 2012 through 2013 (rate difference, -1.5; rate ratio, 1.0). When barriers to cost, access

  20. Access to human, animal, and environmental journals is still limited for the One Health community*

    Science.gov (United States)

    Vreeland, Carol E.; Alpi, Kristine M.; Pike, Caitlin A.; Whitman, Elisabeth E.; Kennedy-Stoskopf, Suzanne

    2016-01-01

    Objective “One Health” is an interdisciplinary approach to evaluating and managing the health and well-being of humans, animals, and the environments they share that relies on knowledge from the domains of human health, animal health, and the environmental sciences. The authors' objective was to evaluate the extent of open access (OA) to journal articles in a sample of literature from these domains. We hypothesized that OA to articles in human health or environmental journals was greater than access to animal health literature. Methods A One Health seminar series provided fifteen topics. One librarian translated each topic into a search strategy and searched four databases for articles from 2011 to 2012. Two independent investigators assigned each article to human health, the environment, animal health, all, other, or combined categories. Article and journal-level OA were determined. Each journal was also assigned a subject category and its indexing evaluated. Results Searches retrieved 2,651 unique articles from 1,138 journals; 1,919 (72%) articles came from 406 journals that contributed more than 1 article. Seventy-seven (7%) journals dealt with all 3 One Health domains; the remaining journals represented human health 487 (43%), environment 172 (15%), animal health 141 (12%), and other/combined categories 261 (23%). The proportion of OA journals in animal health (40%) differed significantly from journals categorized as human (28%), environment (28%), and more than 1 category (29%). The proportion of OA for articles by subject categories ranged from 25%–34%; only the difference between human (34%) and environment (25%) was significant. Conclusions OA to human health literature is more comparable to animal health than hypothesized. Environmental journals had less OA than anticipated. PMID:27076796

  1. A Matter of Discipline: Open Access, the Humanities, and Art History

    Science.gov (United States)

    Tomlin, Patrick

    2009-01-01

    Recent events suggest that open access has gained new momentum in the humanities, but the slow and uneven development of open-access initiatives in humanist fields continues to hinder the consolidation of efforts across the university. Although various studies have traced the general origins of the humanities' reticence to embrace open access, few…

  2. Human Disease Insight: An integrated knowledge-based platform for disease-gene-drug information.

    Science.gov (United States)

    Tasleem, Munazzah; Ishrat, Romana; Islam, Asimul; Ahmad, Faizan; Hassan, Md Imtaiyaz

    2016-01-01

    The scope of the Human Disease Insight (HDI) database is not limited to researchers or physicians as it also provides basic information to non-professionals and creates disease awareness, thereby reducing the chances of patient suffering due to ignorance. HDI is a knowledge-based resource providing information on human diseases to both scientists and the general public. Here, our mission is to provide a comprehensive human disease database containing most of the available useful information, with extensive cross-referencing. HDI is a knowledge management system that acts as a central hub to access information about human diseases and associated drugs and genes. In addition, HDI contains well-classified bioinformatics tools with helpful descriptions. These integrated bioinformatics tools enable researchers to annotate disease-specific genes and perform protein analysis, search for biomarkers and identify potential vaccine candidates. Eventually, these tools will facilitate the analysis of disease-associated data. The HDI provides two types of search capabilities and includes provisions for downloading, uploading and searching disease/gene/drug-related information. The logistical design of the HDI allows for regular updating. The database is designed to work best with Mozilla Firefox and Google Chrome and is freely accessible at http://humandiseaseinsight.com.

  3. HUMAN CAPITAL THEORY AND HUMAN RESOURCE MANAGEMENT. IMPLICATIONS IN DEVELEOPMENT OF KNOWLEDGE MANAGEMENT STRATEGIES

    Directory of Open Access Journals (Sweden)

    Simona Buta

    2015-02-01

    Full Text Available In terms of the organization, the human capital theory and human resource management raises a number of issues, namely: human capital issues (they relate to attracting, maintaining, developing and rewarding human resources in order to create and maintain a skilled, dedicated and motivated personnel; issues related to the structural capital (with reference to the size and development of organizational structures that stimulate the processes of creating, capturing and sizing of knowledge; issues of organizational capital( those related to knowledge management. Therefore, organizational context, several questions arise: What knowledge do we have? What knowledge do we need now and in the future? How can we create an environment and a culture that encourages individual and organizational learning? How can we do so that both explicit and tacit knowledge to be captured stored and used judiciously? This paper focuses on human capital theory, but there will also be raised concepts associated to the human resources and knowledge management. Therefore, in this paper we try to identify ways in which human resources (HR specialists can support the KM strategy to drive value within organisation, by revising the practices in order to ensure the knowledge focus.

  4. Human-centered design of a distributed knowledge management system.

    Science.gov (United States)

    Rinkus, Susan; Walji, Muhammad; Johnson-Throop, Kathy A; Malin, Jane T; Turley, James P; Smith, Jack W; Zhang, Jiajie

    2005-02-01

    Many healthcare technology projects fail due to the lack of consideration of human issues, such as workflow, organizational change, and usability, during the design and implementation stages of a project's development process. Even when human issues are considered, the consideration is typically on designing better user interfaces. We argue that human-centered computing goes beyond a better user interface: it should include considerations of users, functions and tasks that are fundamental to human-centered computing. From this perspective, we integrated a previously developed human-centered methodology with a Project Design Lifecycle, and we applied this integration in the design of a complex distributed knowledge management system for the Biomedical Engineer (BME) domain in the Mission Control Center at NASA Johnson Space Center. We analyzed this complex system, identified its problems, generated systems requirements, and provided specifications of a replacement prototype for effective organizational memory and knowledge management. We demonstrated the value provided by our human-centered approach and described the unique properties, structures, and processes discovered using this methodology and how they contributed in the design of the prototype.

  5. HUMAN RESOURCE MANAGEMENT AND KNOWLEDGE ORGANIZATION IN ESTONIA AND SLOVENIA

    Directory of Open Access Journals (Sweden)

    Dana Mesner Andolšek

    2015-01-01

    Full Text Available The purpose of the analysis is to make a comparison of HRM practices among New Member States (especially Estonia and Slovenia and how these practices help to create the conditions to develop a knowledge organization. In the paper, the systemic and logical analysis of knowledge management concept and its relations with HRM was used. For empirical research a simple exploratory analysis statistical technique was used on Cranet (the Cranfield Network on Comparative Human Resource Management data on HRM practices across countries was used. Major findings allow stating that two important prerequisites for knowledge organization are met and they are successfully implemented through HRM practices especially in organizations in one country. The empirical research findings showed the trends in global economy and the ability of organizations in the New Member States to adapt through institutionally developed HRM practices.

  6. Open Access to Knowledge Resources in Science and Technology : The Role of Digital Reference Service to Facilitate Accessing Scholarly Information

    OpenAIRE

    2005-01-01

    The present paper discusses the importance, objectives and major developments in open access initiatives. It further examines the specific use of digital information services including the digital reference service. The paper also highlights the various steps taken in this direction at the Central Library of IIT Madras.

  7. Semi-automated knowledge discovery: identifying and profiling human trafficking

    Science.gov (United States)

    Poelmans, Jonas; Elzinga, Paul; Ignatov, Dmitry I.; Kuznetsov, Sergei O.

    2012-11-01

    We propose an iterative and human-centred knowledge discovery methodology based on formal concept analysis. The proposed approach recognizes the important role of the domain expert in mining real-world enterprise applications and makes use of specific domain knowledge, including human intelligence and domain-specific constraints. Our approach was empirically validated at the Amsterdam-Amstelland police to identify suspects and victims of human trafficking in 266,157 suspicious activity reports. Based on guidelines of the Attorney Generals of the Netherlands, we first defined multiple early warning indicators that were used to index the police reports. Using concept lattices, we revealed numerous unknown human trafficking and loverboy suspects. In-depth investigation by the police resulted in a confirmation of their involvement in illegal activities resulting in actual arrestments been made. Our human-centred approach was embedded into operational policing practice and is now successfully used on a daily basis to cope with the vastly growing amount of unstructured information.

  8. Digital Accessible Knowledge and well-inventoried sites for birds in Mexico: baseline sites for measuring faunistic change

    OpenAIRE

    A. Townsend PETERSON; Adolfo G. Navarro-Sigüenza; Enrique Martínez-Meyer

    2016-01-01

    Background Faunal change is a basic and fundamental element in ecology, biogeography, and conservation biology, yet vanishingly few detailed studies have documented such changes rigorously over decadal time scales. This study responds to that gap in knowledge, providing a detailed analysis of Digital Accessible Knowledge of the birds of Mexico, designed to marshal DAK to identify sites that were sampled and inventoried rigorously prior to the beginning of major global climate change (1980). M...

  9. From AIDS to Free Trade Agreements: Knowledge Activism in Thailand’s Movement for Access to Medicines

    Directory of Open Access Journals (Sweden)

    Gaelle Pascale Krikorian

    2017-04-01

    Full Text Available This article examines the movement for access to medicines in Thailand, a country that is a privileged site of observation of the new world order of pharmaceuticals and has been at the forefront in many international negotiations on intellectual property. The movement relies on the appropriation of knowledge and expertise about intellectual property laws, which developed in the context of the fight against HIV/AIDS. Treatment activism in Thailand is particularly vigorous and studying it allows us to grasp both the national and transnational dimension of this type of collective action: a global movement that is structured around the notion of "access to medicines," and is in close but rather orthodox relation to medical knowledge. The relations that one can draw between AIDS activism and the movement for access-to-medicines allows one to trace the origins of the latter and helps us understand key features at the core of this movement. But the analysis also shows that, from the outset, the access to medicines movement in Thailand developed through a new form of activism. The notion of knowledge activism is developed in this paper to seize the particularities of the activism at play in Thailand as compared with other forms of collective action relying on the use of knowledge. Knowledge activism is defined not only by the activists’ relation to knowledge–– authoritative and institutionalized knowledge, or lay expertise––but also by the inclusion in the movement of “expert activists” such as doctors, lawyers, or academics, together with “grassroots activists.” Knowledge activism also implies a permanent circulation of knowledge and information between the various categories of actors involved inside, outside and on the fringes of the movement, and results in a hybrid form of collective action that develops beyond the movement and is constantly reconfigured, according to opportunities or pressures.

  10. Co-Producing Accessible Climate Knowledge: Case Study of a Scientific Challenge

    Science.gov (United States)

    Bourqui, M.; Charriere, M. K. M.; Bolduc, C.

    2016-12-01

    This talk presents the process of and the lessons learned from a scientific challenge where climate scientists re-framed their research for the general public in interaction with members of the general public. This challenge was organized by Climanosco in the context of its launch in the fall 2015 and is due to end in September 2016. It led to the publication of 11 articles from scientific authors spanning 7 countries and engaged the participation of 24 members of the general public. The process of interaction between scientists and members of the general public took place along an extended peer-review process which included on-line community discussions and non-scientific review reports. Details of this interaction, as perceived by the participants and evaluated by a survey, will be discussed in this talk. On the longer term this co-production of accessible climate knowledge, which represents the main goal of the non-profit association Climanosco, is meant to serve as a reliable, research-based source, the decision makers but also the journalists, teachers and communities around the world.

  11. The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse.

    Science.gov (United States)

    Blake, Judith A; Bult, Carol J; Eppig, Janan T; Kadin, James A; Richardson, Joel E

    2014-01-01

    The Mouse Genome Database (MGD) (http://www.informatics.jax.org) is the community model organism database resource for the laboratory mouse, a premier animal model for the study of genetic and genomic systems relevant to human biology and disease. MGD maintains a comprehensive catalog of genes, functional RNAs and other genome features as well as heritable phenotypes and quantitative trait loci. The genome feature catalog is generated by the integration of computational and manual genome annotations generated by NCBI, Ensembl and Vega/HAVANA. MGD curates and maintains the comprehensive listing of functional annotations for mouse genes using the Gene Ontology, and MGD curates and integrates comprehensive phenotype annotations including associations of mouse models with human diseases. Recent improvements include integration of the latest mouse genome build (GRCm38), improved access to comparative and functional annotations for mouse genes with expanded representation of comparative vertebrate genomes and new loads of phenotype data from high-throughput phenotyping projects. All MGD resources are freely available to the research community.

  12. Deconstructing Human Papillomavirus (HPV) Knowledge: Objective and Perceived Knowledge in Males' Intentions to Receive the HPV Vaccine

    Science.gov (United States)

    Krawczyk, Andrea; Stephenson, Ellen; Perez, Samara; Lau, Elsa; Rosberger, Zeev

    2013-01-01

    Background: The human papillomavirus (HPV) vaccine was recently approved for men. To effectively tailor HPV education efforts toward men, it is important to understand what men know about HPV and how this knowledge relates to their decision to receive the vaccine. This study examines how objective HPV knowledge, objective HPV vaccine knowledge,…

  13. Deconstructing Human Papillomavirus (HPV) Knowledge: Objective and Perceived Knowledge in Males' Intentions to Receive the HPV Vaccine

    Science.gov (United States)

    Krawczyk, Andrea; Stephenson, Ellen; Perez, Samara; Lau, Elsa; Rosberger, Zeev

    2013-01-01

    Background: The human papillomavirus (HPV) vaccine was recently approved for men. To effectively tailor HPV education efforts toward men, it is important to understand what men know about HPV and how this knowledge relates to their decision to receive the vaccine. This study examines how objective HPV knowledge, objective HPV vaccine knowledge,…

  14. Assessing the Unseen: Using Music and Literature to Access and Develop First Graders' Knowledge of Sound Waves

    Science.gov (United States)

    McCourt, Susan; Kelley, Sybil S.

    2016-01-01

    Most young children love a good song and dance, an enticing story, and gorgeous illustrations. How could this staple of the early childhood classroom--music and literature--access children's ideas about physical science? How can young children communicate their knowledge of unseen science concepts that are not easily represented in pictures? These…

  15. Access to justice: evaluating law, health and human rights programmes in Kenya.

    Science.gov (United States)

    Gruskin, Sofia; Safreed-Harmon, Kelly; Ezer, Tamar; Gathumbi, Anne; Cohen, Jonathan; Kameri-Mbote, Patricia

    2013-11-13

    In Kenya, human rights violations have a marked impact on the health of people living with HIV. Integrating legal literacy and legal services into healthcare appears to be an effective strategy to empower vulnerable groups and address underlying determinants of health. We carried out an evaluation to collect evidence about the impact of legal empowerment programmes on health and human rights. The evaluation focused on Open Society Foundation-supported legal integration activities at four sites: the Academic Model of Providing Access to Healthcare (AMPATH) facility, where the Legal Aid Centre of Eldoret (LACE) operates, in Eldoret; Kenyatta National Hospital's Gender-based Violence Recovery Centre, which hosts the COVAW legal integration program; and Christian Health Association of Kenya (CHAK) facilities in Mombasa and Naivasha. In consultation with the organizations implementing the programs, we designed a conceptual logic model grounded in human rights principles, identified relevant indicators and then coded structure, process and outcome indicators for the rights-related principles they reflect. The evaluation included a resource assessment questionnaire, a review of program records and routine data, and semi-structured interviews and focus group discussions with clients and service providers. Data were collected in May-August 2010 and April-June 2011. Clients showed a notable increase in practical knowledge and awareness about how to access legal aid and claim their rights, as well as an enhanced ability to communicate with healthcare providers and to improve their access to healthcare and justice. In turn, providers became more adept at identifying human rights violations and other legal difficulties, which enabled them to give clients basic information about their rights, refer them to legal aid and assist them in accessing needed support. Methodological challenges in evaluating such activities point to the need to strengthen rights-oriented evaluation

  16. Access to justice: evaluating law, health and human rights programmes in Kenya

    Directory of Open Access Journals (Sweden)

    Sofia Gruskin

    2013-11-01

    Full Text Available Introduction: In Kenya, human rights violations have a marked impact on the health of people living with HIV. Integrating legal literacy and legal services into healthcare appears to be an effective strategy to empower vulnerable groups and address underlying determinants of health. Methods: We carried out an evaluation to collect evidence about the impact of legal empowerment programmes on health and human rights. The evaluation focused on Open Society Foundation-supported legal integration activities at four sites: the Academic Model of Providing Access to Healthcare (AMPATH facility, where the Legal Aid Centre of Eldoret (LACE operates, in Eldoret; Kenyatta National Hospital's Gender-based Violence Recovery Centre, which hosts the COVAW legal integration program; and Christian Health Association of Kenya (CHAK facilities in Mombasa and Naivasha. In consultation with the organizations implementing the programs, we designed a conceptual logic model grounded in human rights principles, identified relevant indicators and then coded structure, process and outcome indicators for the rights-related principles they reflect. The evaluation included a resource assessment questionnaire, a review of program records and routine data, and semi-structured interviews and focus group discussions with clients and service providers. Data were collected in May–August 2010 and April–June 2011. Results: Clients showed a notable increase in practical knowledge and awareness about how to access legal aid and claim their rights, as well as an enhanced ability to communicate with healthcare providers and to improve their access to healthcare and justice. In turn, providers became more adept at identifying human rights violations and other legal difficulties, which enabled them to give clients basic information about their rights, refer them to legal aid and assist them in accessing needed support. Methodological challenges in evaluating such activities point to

  17. Organizing conceptual knowledge in humans with a gridlike code.

    Science.gov (United States)

    Constantinescu, Alexandra O; O'Reilly, Jill X; Behrens, Timothy E J

    2016-06-17

    It has been hypothesized that the brain organizes concepts into a mental map, allowing conceptual relationships to be navigated in a manner similar to that of space. Grid cells use a hexagonally symmetric code to organize spatial representations and are the likely source of a precise hexagonal symmetry in the functional magnetic resonance imaging signal. Humans navigating conceptual two-dimensional knowledge showed the same hexagonal signal in a set of brain regions markedly similar to those activated during spatial navigation. This gridlike signal is consistent across sessions acquired within an hour and more than a week apart. Our findings suggest that global relational codes may be used to organize nonspatial conceptual representations and that these codes may have a hexagonal gridlike pattern when conceptual knowledge is laid out in two continuous dimensions.

  18. Can free open access resources strengthen knowledge-based emerging public health priorities, policies and programs in Africa?

    Science.gov (United States)

    Tambo, Ernest; Madjou, Ghislaine; Khayeka-Wandabwa, Christopher; Tekwu, Emmanuel N.; Olalubi, Oluwasogo A.; Midzi, Nicolas; Bengyella, Louis; Adedeji, Ahmed A.; Ngogang, Jeanne Y.

    2016-01-01

    Tackling emerging epidemics and infectious diseases burden in Africa requires increasing unrestricted open access and free use or reuse of regional and global policies reforms as well as timely communication capabilities and strategies. Promoting, scaling up data and information sharing between African researchers and international partners are of vital importance in accelerating open access at no cost. Free Open Access (FOA) health data and information acceptability, uptake tactics and sustainable mechanisms are urgently needed. These are critical in establishing real time and effective knowledge or evidence-based translation, proven and validated approaches, strategies and tools to strengthen and revamp health systems.  As such, early and timely access to needed emerging public health information is meant to be instrumental and valuable for policy-makers, implementers, care providers, researchers, health-related institutions and stakeholders including populations when guiding health financing, and planning contextual programs. PMID:27508058

  19. Can free open access resources strengthen knowledge-based emerging public health priorities, policies and programs in Africa?

    Science.gov (United States)

    Tambo, Ernest; Madjou, Ghislaine; Khayeka-Wandabwa, Christopher; Tekwu, Emmanuel N; Olalubi, Oluwasogo A; Midzi, Nicolas; Bengyella, Louis; Adedeji, Ahmed A; Ngogang, Jeanne Y

    2016-01-01

    Tackling emerging epidemics and infectious diseases burden in Africa requires increasing unrestricted open access and free use or reuse of regional and global policies reforms as well as timely communication capabilities and strategies. Promoting, scaling up data and information sharing between African researchers and international partners are of vital importance in accelerating open access at no cost. Free Open Access (FOA) health data and information acceptability, uptake tactics and sustainable mechanisms are urgently needed. These are critical in establishing real time and effective knowledge or evidence-based translation, proven and validated approaches, strategies and tools to strengthen and revamp health systems.  As such, early and timely access to needed emerging public health information is meant to be instrumental and valuable for policy-makers, implementers, care providers, researchers, health-related institutions and stakeholders including populations when guiding health financing, and planning contextual programs.

  20. Impact of Gender Binarism on Hijras' Life Course and Their Access to Fundamental Human Rights in Pakistan.

    Science.gov (United States)

    Alizai, Aurangzaib; Doneys, Philippe; Doane, Donna L

    2017-01-01

    This study adds to the growing body of knowledge on gender nonconformity aspects of heteronormativity by examining its impact on the life course of hijras and their access to fundamental human rights in Pakistan. Drawing on 50 semistructured interviews conducted in two sites, the findings suggest that the participants' lived experiences associated with gender nonconformity significantly influenced the direction of their life course and their ability to have access to human rights. These experiences spanned from childhood to elderhood across a wide range of settings, such as family, school, guru dera (residence headed by a hijra guru), workplace, and interactions with authorities. The participants' human rights were not recognized, resulting in abuse, social stigma, discrimination against them, and their exclusion from mainstream society. Finally, implications are drawn for public policy and future research on third gender concerns in Pakistan and elsewhere.

  1. Human Capital and Knowledge Emergence. Induced Effects of the Global Crisis on Human capital and Innovation

    Directory of Open Access Journals (Sweden)

    Simona Buta

    2014-12-01

    Full Text Available In the global crisis context crossed by organizations and countries in the past six years we assist also at conflicting measures in which regards knowledge, innovation and human capital; for example, countries such as England and France have reduced their costs for education, while Germany and other countries (Australia, Austria, Canada and Norway maintained the same allocations for education. What will be the effects of such measures on human capital in the near future? What are the best human resources policies in companies in the crisis context? Given that the subject of the research is "knowledge and human capital", in this paper we refer to the induced effects of the crisis on human capital and innovation. We will also identify the key steps that can be taken during crisis, and not only, to stimulate human capital.

  2. Human membrane transporter database: a Web-accessible relational database for drug transport studies and pharmacogenomics.

    Science.gov (United States)

    Yan, Q; Sadée, W

    2000-01-01

    The human genome contains numerous genes that encode membrane transporters and related proteins. For drug discovery, development, and targeting, one needs to know which transporters play a role in drug disposition and effects. Moreover, genetic polymorphisms in human membrane transporters may contribute to interindividual differences in the response to drugs. Pharmacogenetics, and, on a genome-wide basis, pharmacogenomics, address the effect of genetic variants on an individual's response to drugs and xenobiotics. However, our knowledge of the relevant transporters is limited at present. To facilitate the study of drug transporters on a broad scale, including the use of microarray technology, we have constructed a human membrane transporter database (HMTD). Even though it is still largely incomplete, the database contains information on more than 250 human membrane transporters, such as sequence, gene family, structure, function, substrate, tissue distribution, and genetic disorders associated with transporter polymorphisms. Readers are invited to submit additional data. Implemented as a relational database, HMTD supports complex biological queries. Accessible through a Web browser user interface via Common Gateway Interface (CGI) and Java Database Connection (JDBC), HMTD also provides useful links and references, allowing interactive searching and downloading of data. Taking advantage of the features of an electronic journal, this paper serves as an interactive tutorial for using the database, which we expect to develop into a research tool.

  3. HINT-KB: The human interactome knowledge base

    KAUST Repository

    Theofilatos, Konstantinos A.

    2012-01-01

    Proteins and their interactions are considered to play a significant role in many cellular processes. The identification of Protein-Protein interactions (PPIs) in human is an open research area. Many Databases, which contain information about experimentally and computationally detected human PPIs as well as their corresponding annotation data, have been developed. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://150.140.142.24:84/Default.aspx) which is a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, estimates a set of features of interest and computes a confidence score for every candidate protein interaction using a modern computational hybrid methodology. © 2012 IFIP International Federation for Information Processing.

  4. Snag density varies with intensity of timber harvest and human access

    Science.gov (United States)

    Michael J. Wisdom; Lisa J. Bate

    2008-01-01

    Many species of vertebrates depend on snags (standing dead trees) for persistence, and limited research suggests that snag density is lower in areas of intensive timber harvest and increased human access. While intensive timber harvest is one source of potential snag loss, ease of human access to forest stands may also facilitate loss via firewood cutting of snags....

  5. Access to health care for undocumented migrants from a human rights perspective:

    DEFF Research Database (Denmark)

    Biswas, Dan; Toebes, Brigit; Hjern, Anders

    2012-01-01

    Undocumented migrants' access to health care varies across Europe, and entitlements on national levels are often at odds with the rights stated in international human rights law. The aim of this study is to address undocumented migrants' access to health care in Denmark, Sweden, and the Netherlands...... from a human rights perspective....

  6. Linking person perception and person knowledge in the human brain.

    Science.gov (United States)

    Greven, Inez M; Downing, Paul E; Ramsey, Richard

    2016-04-01

    Neuroscience research has examined separately how we detect human agents on the basis of their face and body (person perception) and how we reason about their thoughts, traits or intentions (person knowledge). Neuroanatomically distinct networks have been associated with person perception and person knowledge, but it remains unknown how multiple features of a person (e.g. thin and kind) are linked to form a holistic identity representation. In this fMRI experiment, we investigated the hypothesis that when encountering another person specialised person perception circuits would be functionally coupled with circuits involved in person knowledge. In a factorial design, we paired bodies or names with trait-based or neutral statements, and independent localiser scans identified body-selective and mentalising networks. When observing a body paired with a trait-implying statement, functional connectivity analyses demonstrated that body-selective patches in bilateral fusiform gyri were functionally coupled with nodes of the mentalising network. We demonstrate that when forming a representation of a person circuits for representing another person's physical appearance are linked to circuits that are engaged when reasoning about trait-based character. These data support the view that a 'who' system for social cognition involves communication between perceptual and inferential mechanisms when forming a representation of another's identity.

  7. Access to electronic health knowledge in five countries in Africa: a descriptive study

    Directory of Open Access Journals (Sweden)

    Honorati Masanja

    2007-05-01

    Full Text Available Abstract Background Access to medical literature in developing countries is helped by open access publishing and initiatives to allow free access to subscription only journals. The effectiveness of these initiatives in Africa has not been assessed. This study describes awareness, reported use and factors influencing use of on-line medical literature via free access initiatives. Methods Descriptive study in four teaching hospitals in Cameroon, Nigeria, Tanzania and Uganda plus one externally funded research institution in The Gambia. Survey with postgraduate doctors and research scientists to determine Internet access patterns, reported awareness of on-line medical information and free access initiatives; semi structured interviews with a sub-sample of survey participants to explore factors influencing use. Results In the four African teaching hospitals, 70% of the 305 postgraduate doctors reported textbooks as their main source of information; 66% had used the Internet for health information in the last week. In two hospitals, Internet cafés were the main Internet access point. For researchers at the externally-funded research institution, electronic resources were their main source, and almost all had used the Internet in the last week. Across all 333 respondents, 90% had heard of PubMed, 78% of BMJ on line, 49% the Cochrane Library, 47% HINARI, and 19% BioMedCentral. HINARI use correlates with accessing the Internet on computers located in institutions. Qualitative data suggested there are difficulties logging into HINARI and that sometimes it is librarians that limit access to passwords. Conclusion Text books remain an important resource for postgraduate doctors in training. Internet use is common, but awareness of free-access initiatives is limited. HINARI and other initiatives could be more effective with strong institutional endorsement and management to promote and ensure access.

  8. Web Accessibility Knowledge and Skills for Non-Web Library Staff

    Science.gov (United States)

    McHale, Nina

    2012-01-01

    Why do librarians and library staff other than Web librarians and developers need to know about accessibility? Web services staff do not--or should not--operate in isolation from the rest of the library staff. It is important to consider what areas of online accessibility are applicable to other areas of library work and to colleagues' regular job…

  9. Efficacy of Video-Assisted Instruction on Knowledge and Performance of Dental Students in Access Cavity Preparation

    OpenAIRE

    Naseri, Mandana; Shantiaee, Yazdan; Rasekhi, Javid; Zadsirjan, Saeede; Mojtahed Bidabadi, Maryam; Khayat, Akbar

    2016-01-01

    Introduction: The conventional method of teaching endodontics has some drawbacks. Due to the small size of the oral cavity, students cannot closely observe the clinical procedure. Use of new teaching modalities such as the intraoral camera may obviate this problem. This study assessed the effect of video-assisted clinical instruction in dentistry (VACID) on dental student’s knowledge and performance in access cavity preparation during endodontic treatment. Methods and Materials: In this inter...

  10. Open access: academic publishing and its implications for knowledge equity in Kenya.

    Science.gov (United States)

    Matheka, Duncan Mwangangi; Nderitu, Joseph; Mutonga, Daniel; Otiti, Mary Iwaret; Siegel, Karen; Demaio, Alessandro Rhyll

    2014-04-09

    Traditional, subscription-based scientific publishing has its limitations: often, articles are inaccessible to the majority of researchers in low- and middle-income countries (LMICs), where journal subscriptions or one-time access fees are cost-prohibitive. Open access (OA) publishing, in which journals provide online access to articles free of charge, breaks this barrier and allows unrestricted access to scientific and scholarly information to researchers all over the globe. At the same time, one major limitation to OA is a high publishing cost that is placed on authors. Following recent developments to OA publishing policies in the UK and even LMICs, this article highlights the current status and future challenges of OA in Africa. We place particular emphasis on Kenya, where multidisciplinary efforts to improve access have been established. We note that these efforts in Kenya can be further strengthened and potentially replicated in other African countries, with the goal of elevating the visibility of African research and improving access for African researchers to global research, and, ultimately, bring social and economic benefits to the region. We (1) offer recommendations for overcoming the challenges of implementing OA in Africa and (2) call for urgent action by African governments to follow the suit of high-income countries like the UK and Australia, mandating OA for publicly-funded research in their region and supporting future research into how OA might bring social and economic benefits to Africa.

  11. Open-Access Textbooks and Financial Sustainability: A Case Study on Flat World Knowledge

    Directory of Open Access Journals (Sweden)

    John Hilton III

    2011-06-01

    Full Text Available Many college students and their families are concerned about the high costs of textbooks. A company called Flat World Knowledge both gives away and sells open-source textbooks in a way it believes to be financially sustainable. This article reports on the financial sustainability of the Flat World Knowledge open-source textbook model after one year of operation.

  12. Open-Access Textbooks and Financial Sustainability: A Case Study on Flat World Knowledge

    Science.gov (United States)

    Hilton, John, III; Wiley, David

    2011-01-01

    Many college students and their families are concerned about the high costs of textbooks. A company called Flat World Knowledge both gives away and sells open-source textbooks in a way it believes to be financially sustainable. This article reports on the financial sustainability of the Flat World Knowledge open-source textbook model after one…

  13. University Students' Knowledge and Attitudes Regarding Cervical Cancer, Human Papillomavirus, and Human Papillomavirus Vaccines in Turkey

    Science.gov (United States)

    Koç, Zeliha

    2015-01-01

    Objectives: The current descriptive study aimed to determine university students' knowledge and attitudes regarding cervical cancer, human papillomavirus (HPV), and HPV vaccines in Turkey. Participants: A total of 800 students participated. Methods: This study was carried out between September 1, 2012, and October 30, 2012, in 8 female…

  14. University Students' Knowledge and Attitudes Regarding Cervical Cancer, Human Papillomavirus, and Human Papillomavirus Vaccines in Turkey

    Science.gov (United States)

    Koç, Zeliha

    2015-01-01

    Objectives: The current descriptive study aimed to determine university students' knowledge and attitudes regarding cervical cancer, human papillomavirus (HPV), and HPV vaccines in Turkey. Participants: A total of 800 students participated. Methods: This study was carried out between September 1, 2012, and October 30, 2012, in 8 female…

  15. Human rights responsibilities of pharmaceutical companies in relation to access to medicines.

    Science.gov (United States)

    Lee, Joo-Young; Hunt, Paul

    2012-01-01

    Although access to medicines is a vital feature of the right to the highest attainable standard of health ("right to health"), almost two billion people lack access to essential medicines, leading to immense avoidable suffering. While the human rights responsibility to provide access to medicines lies mainly with States, pharmaceutical companies also have human rights responsibilities in relation to access to medicines. This article provides an introduction to these responsibilities. It briefly outlines the new UN Guiding Principles on Business and Human Rights and places the human rights responsibilities of pharmaceutical companies in this context. The authors draw from the work of the first UN Special Rapporteur on the right to the highest attainable standard of health, in particular the Human Rights Guidelines for Pharmaceutical Companies in Relation to Access to Medicines that he presented to the UN General Assembly in 2008, and his UN report on GlaxoSmithKline (GSK). While the Guiding Principles on Business and Human Rights are general human rights standards applicable to all business entities, the Human Rights Guidelines for Pharmaceutical Companies consider the specific human rights responsibilities of one sector (pharmaceutical companies) in relation to one area of activity (access to medicines). The article signals the human rights responsibilities of all pharmaceutical companies, with particular attention to patent-holding pharmaceutical companies. Adopting a right-to-health "lens," the article discusses GSK and accountability. The authors argue that human rights should shape pharmaceutical companies' policies, and provide standards in relation to which pharmaceutical companies could, and should, be held accountable. They conclude that it is now crucial to devise independent, accessible, transparent, and effective mechanisms to monitor pharmaceutical companies and hold them publicly accountable for their human rights responsibilities.

  16. Teenagers’ knowledge of human sexuality and their views on teenage pregnancies

    OpenAIRE

    P J Kunene

    1995-01-01

    There is concern about poor knowledge of human sexuality and a high rate of teenage pregnancies among Blacks. The primary aim of the study was to measure the knowledge that teenagers have on human sexuality and to identify the sources from which they obtain such knowledge. The secondary aim was to detect how teenagers perceive the teenage pregnancy problem and its consequences,

  17. Knowledge Management, Human Resource Management, and Higher Education: A Theoretical Model

    Science.gov (United States)

    Brewer, Peggy D.; Brewer, Kristen L.

    2010-01-01

    Much has been written on the importance of knowledge management, the challenges facing organizations, and the important human resource management activities involved in assuring the acquisition and transfer of knowledge. Higher business education plays an important role in preparing students to assume the knowledge management and human resource…

  18. Knowledge Management, Human Resource Management, and Higher Education: A Theoretical Model

    Science.gov (United States)

    Brewer, Peggy D.; Brewer, Kristen L.

    2010-01-01

    Much has been written on the importance of knowledge management, the challenges facing organizations, and the important human resource management activities involved in assuring the acquisition and transfer of knowledge. Higher business education plays an important role in preparing students to assume the knowledge management and human resource…

  19. Access to health care for undocumented migrants from a human rights perspective:

    DEFF Research Database (Denmark)

    Biswas, Dan; Toebes, Brigit; Hjern, Anders

    2012-01-01

    Undocumented migrants' access to health care varies across Europe, and entitlements on national levels are often at odds with the rights stated in international human rights law. The aim of this study is to address undocumented migrants' access to health care in Denmark, Sweden, and the Netherlands...

  20. Knowledge-Based Multiple Access Protocol in Broadband Wireless ATM Networks

    DEFF Research Database (Denmark)

    Liu, Hong; Gliese, Ulrik Bo; Dittmann, Lars

    1999-01-01

    characteristics of the traffic for allocating bandwidth effeciently to CBR, VBR and ABR/UBR connections by a compromise of assignment, contetion, reservation and polling access techniques. Simulation results show that the proposed protocol can achieve a very high channel utilization of 90 % while providing...... guaranteed QoS requirements to a variety of ATM applications....

  1. The Potential of ICT for a New Educational Paradigm: Toward Generalizing Access to Knowledge

    Science.gov (United States)

    Trebbi, Turid

    2011-01-01

    This article both analyzes and synthesizes eleven articles from four volumes (eight issues) of the journal "Distances et Savoirs" published between 2003 and 2008. The authors of these articles present their research on several topics related to learners, learning, and tutoring in distance education while also working on innovation and access to…

  2. Electricity access for human development in the Brazilian Amazon

    Energy Technology Data Exchange (ETDEWEB)

    Gomez Galindo, Maria Fernanda

    2012-07-01

    Electricity access is widely recognized as a driver of development. The Brazilian government has incorporated this principle into its national rural electrification program, Luz Para Todos (LPT - Light for all), which has already benefited more than 14 million people in the country since its inception in 2003. But a different electrification model is required if remote areas in the Amazon region are to fully benefit from the program. In general, LPT has been implemented through a grid-based technology. However, the program has been less successful in providing electricity access in the Amazon region. In this region, about 24 % of the rural population has no access to electricity. Key challenges are related to the exhaustion of the grid-extension model in isolated areas. Extending the grid in these areas is neither realistic because of the local topography and natural conditions, nor cost-effective because expensive investments would be required to benefit a small number of citizens with low income and consumption rates. This study suggests an adapted LPT model for delivering electricity access in isolated areas of the Amazon region. In particular, the study offers a policy maker perspective and details the specific needs of isolated communities. It was developed in the form of a case study and included a variety of data sources, gathering techniques and analysis approaches, including an extensive literature review, the collection of in-situ evidence through direct observations and semi-structured interviews. Conclusions draw attention to the need for more local and site-specific solutions. Three issues will be decisive in achieving universal, reliable and affordable access to electricity in the Amazon region. Firstly, harmonization with the regional context is essential as the Amazon is a vast and unique environment. Secondly, there is need for adapting the existing institutional structures to appreciate the conditions and specific needs of rural populations in the

  3. Efficacy of Video-Assisted Instruction on Knowledge and Performance of Dental Students in Access Cavity Preparation

    Science.gov (United States)

    Naseri, Mandana; Shantiaee, Yazdan; Rasekhi, Javid; Zadsirjan, Saeede; Mojtahed Bidabadi, Maryam; Khayat, Akbar

    2016-01-01

    Introduction: The conventional method of teaching endodontics has some drawbacks. Due to the small size of the oral cavity, students cannot closely observe the clinical procedure. Use of new teaching modalities such as the intraoral camera may obviate this problem. This study assessed the effect of video-assisted clinical instruction in dentistry (VACID) on dental student’s knowledge and performance in access cavity preparation during endodontic treatment. Methods and Materials: In this interventional study, twenty six undergraduate students were equally divided into two groups and received instructions on access cavity preparation via conventional demonstration (CD) or VACID using intraoral camera plus conventional demonstration. Students’ knowledge was assessed before and after the demonstration. The scores obtained by students were compared between the two groups. Data were analyzed using the Mann Whitney U test. Results: No significant difference was found between the two groups in knowledge and performance scores of students about pulp chamber removal, under-extension, over-extension, gouging, perforation or finding the main and extra canals. However, use of intraoral camera significantly reduced the number of student visits to instructors for problem solving (P=0.001). Conclusion: VACID is an effective educational method and as efficient as conventional demonstration in endodontics; as a result it can be used in combination with conventional teaching. PMID:27790265

  4. Psychological Basis of the Relationship Between the Rorschach Texture Response and Adult Attachment: The Mediational Role of the Accessibility of Tactile Knowledge.

    Science.gov (United States)

    Iwasa, Kazunori; Ogawa, Toshiki

    2016-01-01

    This study clarifies the psychological basis for the linkage between adult attachment and the texture response on the Rorschach by examining the mediational role of the accessibility of tactile knowledge. Japanese undergraduate students (n = 35) completed the Rorschach Inkblot Method, the Experiences in Close Relationship Scale for General Objects (Nakao & Kato, 2004) and a lexical decision task designed to measure the accessibility of tactile knowledge. A mediation analysis revealed that the accessibility of tactile knowledge partially mediates the association between attachment anxiety and the texture response. These results suggest that our hypothetical model focusing on the response process provides a possible explanation of the relationship between the texture response and adult attachment.

  5. Reviews and Practice of College Students Regarding Access to Scientific Knowledge: A Case Study in Two Spanish Universities

    Directory of Open Access Journals (Sweden)

    José Manuel Sáez López

    2013-09-01

    Full Text Available This study analyzes the concepts, attitudes, and practices of 327 pedagogy students from two major Spanish universities related to the process of finding academic information utilizing open access. A training program has been developed through an innovation project (PIMCD to address the problem of the lack of university training designed to enable students to access reliable sources of scientific knowledge. A mixed questionnaire with a pretest-posttest design, applying a descriptive analysis, a factor analysis, and a Wilcoxon test was administered to students. The results show that it is essential to provide information and training to encourage university students to learn how to find and manage rigorous and reliable sources of information. While searching for academic information, Spanish students tend to focus on the use of Google and, to a lesser extent, Google Scholar. Although there are no significant limitations of access to Spanish language articles, students’ attitudes remain very positive towards the concept of open access. In short, in accordance with the study results, the promotion of educational activities relating to the search for and selection of information and the use of reliable and rigorous academic content is highly recommended in the university context.

  6. Massive Access Control Aided by Knowledge-Extraction for Co-Existing Periodic and Random Services over Wireless Clinical Networks.

    Science.gov (United States)

    Du, Qinghe; Zhao, Weidong; Li, Weimin; Zhang, Xuelin; Sun, Bo; Song, Houbing; Ren, Pinyi; Sun, Li; Wang, Yichen

    2016-07-01

    The prosperity of e-health is boosted by fast development of medical devices with wireless communications capability such as wearable devices, tiny sensors, monitoring equipments, etc., which are randomly distributed in clinic environments. The drastically-increasing population of such devices imposes new challenges on the limited wireless resources. To relieve this problem, key knowledge needs to be extracted from massive connection attempts dispersed in the air towards efficient access control. In this paper, a hybrid periodic-random massive access (HPRMA) scheme for wireless clinical networks employing ultra-narrow band (UNB) techniques is proposed. In particular, the proposed scheme towards accommodating a large population of devices include the following new features. On one hand, it can dynamically adjust the resource allocated for coexisting periodic and random services based on the traffic load learned from signal collision status. On the other hand, the resource allocation within periodic services is thoroughly designed to simultaneously align with the timing requests of differentiated services. Abundant simulation results are also presented to demonstrate the superiority of the proposed HPRMA scheme over baseline schemes including time-division multiple access (TDMA) and random access approach, in terms of channel utilization efficiency, packet drop ratio, etc., for the support of massive devices' services.

  7. Adult age differences in memory in relation to availability and accessibility of knowledge-based schemas.

    Science.gov (United States)

    Arbuckle, T Y; Vanderleck, V F; Harsany, M; Lapidus, S

    1990-03-01

    Three experiments investigated whether, over adulthood, the use of schemas to process and remember new information increases (developmental shift hypothesis), decreases (production deficiency hypothesis) or remains constant (age-invariance hypothesis). Effects of schema access were studied by having young, middle-aged, and old music experts and nonexperts recall information that was relevant or irrelevant to music (Experiment 1) and by comparing young and old participants' memory for prose passages when they knew or did not know the subject of the passage (Experiments 2 and 3). In each case, schema access facilitated memory equally across age levels, supporting the age-invariance hypothesis and implying that the basic structures and operations of memory do not necessarily change with age. Possible limits on the independence of age and schema utilization were considered in relation to the conditions under which each of the two alternative hypotheses might hold.

  8. The Encyclopedia of Life v2: Providing Global Access to Knowledge About Life on Earth.

    Science.gov (United States)

    Parr, Cynthia S; Wilson, Nathan; Leary, Patrick; Schulz, Katja S; Lans, Kristen; Walley, Lisa; Hammock, Jennifer A; Goddard, Anthony; Rice, Jeremy; Studer, Marie; Holmes, Jeffrey T G; Corrigan, Robert J

    2014-01-01

    The Encyclopedia of Life (EOL, http://eol.org) aims to provide unprecedented global access to a broad range of information about life on Earth. It currently contains 3.5 million distinct pages for taxa and provides content for 1.3 million of those pages. The content is primarily contributed by EOL content partners (providers) that have a more limited geographic, taxonomic or topical scope. EOL aggregates these data and automatically integrates them based on associated scientific names and other classification information. EOL also provides interfaces for curation and direct content addition. All materials in EOL are either in the public domain or licensed under a Creative Commons license. In addition to the web interface, EOL is also accessible through an Application Programming Interface. In this paper, we review recent developments added for Version 2 of the web site and subsequent releases through Version 2.2, which have made EOL more engaging, personal, accessible and internationalizable. We outline the core features and technical architecture of the system. We summarize milestones achieved so far by EOL to present results of the current system implementation and establish benchmarks upon which to judge future improvements. We have shown that it is possible to successfully integrate large amounts of descriptive biodiversity data from diverse sources into a robust, standards-based, dynamic, and scalable infrastructure. Increasing global participation and the emergence of EOL-powered applications demonstrate that EOL is becoming a significant resource for anyone interested in biological diversity.

  9. Access to healthcare services as a human right.

    Science.gov (United States)

    Kirby, N

    2010-12-01

    The existence of a right to healthcare or, at least, access to healthcare services, is a right that exists in terms of the Bill of Rights in the Constitution of the Republic of South Africa, 1996. This article explores the scope and ambit of the right and its meaning within the context of both of constitutional directives, the duties imposed upon the State to progressively realise the right for its citizens and the practical implications of the right with reference to existing healthcare infrastructure in the Republic of South Africa.

  10. Unspoken knowledge: implicit learning of structured human dance movement.

    Science.gov (United States)

    Opacic, Tajana; Stevens, Catherine; Tillmann, Barbara

    2009-11-01

    The sequencing of dance movements may be thought of as a grammar. We investigate implicit learning of regularities that govern sequences of unfamiliar, discrete dance movements. It was hypothesized that observers without prior experience with contemporary dance would be able to learn regularities that underpin structured human movement. Thirty-one adults were assigned to either an exposure or a control group. Exposure consisted of 22 grammatical 3-, 4-, and 5-movement sequences presented twice in random order; sequence duration ranged from 9 to 19 s. In a test phase, exposure and control groups identified previously unseen sequences as grammatical or ungrammatical, and rated confidence of judgment. The exposure group selected significantly more new grammatical sequences in the test phase than the control group. In addition, for the exposure group, the zero correlation criterion, wherein no relation between confidence and accuracy indicates unconscious knowledge, was satisfied. Through exposure, novice observers can learn a grammar that governs the sequencing of dance movements. This has implications for implicit learning of long sequences, working memory, and the development of expectations through exposure to contemporary dance.

  11. Multiple choice exams of medical knowledge with open books and web access? A validity study

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Simonsen, Eivind Ortind; Knudsen, Ulla Breth

    2015-01-01

    Background: Open book tests have been suggested to lower test anxiety and promote deeper learning strategies. In the Aarhus University medical program, ¼ of the curriculum assess students’ medical knowledge with ‘open book, open web’ (OBOW) multiple choice examinations. We found little existing...

  12. An Investigation of Graduate Student Knowledge and Usage of Open-Access Journals

    Science.gov (United States)

    Beard, Regina M.

    2016-01-01

    Graduate students lament the need to achieve the proficiency necessary to competently search multiple databases for their research assignments, regularly eschewing these sources in favor of Google Scholar or some other search engine. The author conducted an anonymous survey investigating graduate student knowledge or awareness of the open-access…

  13. Accessing stored knowledge of familiar people from faces, names and voices: a review.

    Science.gov (United States)

    Hanley, John Richard

    2014-01-01

    Recent findings from neuropsychology and experimental psychology appear incompatible with the claim that feelings of familiarity about known people require activation of amodal person identity nodes. Evidence suggests that there are modality-specific effects after the point at which faces, names and voices have been found familiar. It therefore appears that activation of distinct modality-specific face, name and voice processing systems can signal that a known person is familiar. There is no convincing evidence, however, of modular effects on the way that information about familiar people is represented in semantic memory. Instead, semantic information about people appears to be stored separately from other forms of knowledge such as knowledge of objects. Anatomical evidence suggests that amodal person-specific semantic knowledge is stored in the right anterior temporal lobe where it has close connections with modality specific recognition systems. Failures to retrieve names in proper name anomia may be caused by impairments to the links between semantic knowledge in the right anterior temporal lobe and lexical representations in the left temporal pole.

  14. Developing Accessible Cyberinfrastructure-Enabled Knowledge Communities in the National Disability Community: Theory, Practice, and Policy

    Science.gov (United States)

    Myhill, William N.; Cogburn, Derrick L.; Samant, Deepti

    2008-01-01

    Since publication of the Atkins Commission report 2003, the national scientific community has placed significant emphasis on developing cyberinfrastructure-enabled knowledge communities, which are designed to facilitate enhanced efficiency and collaboration in geographically distributed networks of researchers. This article suggests that the new…

  15. Epistemology – the Theory of Knowledge or Knowing? Appreciating Gregory Bateson’s Contribution to the Cartography of Human Cognition

    Directory of Open Access Journals (Sweden)

    Zdzislaw Wasik

    2017-01-01

    Full Text Available This article aims at a confrontation of two approaches to epistemology in order to answer the question posed in its title whether the theory of knowledge should focus on static or dynamic aspects of human cognition. In the first part, the author presents a metascientific understanding of epistemology defined in his own works as an ordered set of investigative perspectives, which practicing researchers have at their disposal when they are interested to attain a specific state of knowledge, or to support their beliefs about the nature of investigative domains with regard to the existence forms and accessibility of investigated objects. And, in the second, the subject matter of a more detailed presentation constitutes a psychophysiological approach to epistemology pertaining to the human organism preoccupied with sensorial and mental activities as a cognizing subject who aims at achieving a certain kind of information about reality. Common for both approaches to epistemology is the attainment of experiential knowledge. However, when the metascientific epistemology refers to a dispositional-perspectivistic state of knowledge acquired in cognition, the attention of the psychophysiological epistemology is paid to cognitive-constructivists activities of human organisms as subject acquiring their knowledge through personal experiences.

  16. Localized Knowledge based System for Human Disease Diagnosis

    Directory of Open Access Journals (Sweden)

    Adane Nega Tarekegn

    2016-03-01

    Full Text Available —Knowledge based system can be designed to solve complex medical problems. It incorporates the expert‟s knowledge that has been coded into facts, rules, heuristics and procedures. Incorporation of local languages with the knowledge based system allows endusers communicate with the system in a simpler and easier way. In this study a localized knowledge based system is developed for TB disease diagnosis using Ethiopian national language. To develop the localized knowledge based system, tacit knowledge is acquired from domain experts using interviewing techniques and explicit knowledge is captured from documented sources using relevant documents analysis method. Then the acquired knowledge is modeled using decision tree structure that represents concepts and procedures involved in diagnosis of disease. Production rules are used to represent domain knowledge. The localized knowledge based system is developed using SWI Prolog version 6.4.1 programming language. Prolog supports natural language processing feature to localize the system. As a result, the system is implemented using Amharic language (the national language of Ethiopia user interface. With Localization, users at remote areas and users who are not good in foreign languages are benefited enormously. The system is tested and evaluated to ensure that whether the performance of the system is accurate and the system is usable by physicians and patients. The average performance of the localized knowledge based system has registered 81.5%.

  17. Considerations on private human access to space from an institutional point of view

    Science.gov (United States)

    Hufenbach, Bernhard

    2013-12-01

    Private human access to space as discussed in this article addresses two market segments: suborbital flight and crew flights to Low Earth Orbit. The role of entrepreneurs, the technical complexity, the customers, the market conditions as well as the time to market in these two segments differ significantly. Space agencies take currently a very different approach towards private human access to space in both segments. Analysing the outcome of broader inter-agency deliberations on the future of human spaceflight and exploration, performed e.g. in the framework of the International Space Exploration Coordination Group, enables to derive some common general views on this topic. Various documents developed by inter-agency working groups recognise the general strategic importance for enabling private human access to space for ensuring a sustainable future of human spaceflight, although the specific definition of private human access and approaches vary. ESA has performed some reflections on this subject throughout the last 5 years. While it gained through these reflections a good understanding on the opportunities and implications resulting from the development of capabilities and markets for Private Human Access, limited concrete activities have been initiated in relation to this topic as of today.

  18. Mothers' human papilloma virus knowledge and willingness to vaccinate their adolescent daughters in Lagos, Nigeria

    Directory of Open Access Journals (Sweden)

    Ezenwa BN

    2013-07-01

    Full Text Available Beatrice N Ezenwa,1 Mobolanle R Balogun,2 Ifeoma P Okafor2 1Department of Pediatrics, 68 Nigerian Army Reference Hospital, Lagos State, Nigeria; 2Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos State, Nigeria Introduction: Human papillomavirus (HPV is one of the most common sexually transmitted infections in sexually active adolescents and young women and has been implicated as a cause of the majority of cases of cervical cancer, which is the second most common cancer in women in Nigeria. HPV is preventable with the use of HPV vaccines. Objectives: The objective of this study was to assess mothers' HPV knowledge and their willingness to vaccinate their adolescent daughters in Lagos, Nigeria. Materials and methods: This study was a community-based, descriptive cross-sectional study carried out in July, 2012 in Shomolu Local Government Area (LGA of Lagos State, Nigeria. Multistage sampling method was employed to select the 290 respondents who participated in the study. Structured, pretested, interviewer-administered questionnaires were used for data collection. Data was analyzed with Epi-Info™ version 7. Results: The study revealed low awareness of HPV (27.9% and HPV vaccines (19.7% among the mothers that participated. There was a high awareness for cervical cancer but little knowledge of its link to HPV. Awareness and utilization of HPV vaccines increased with increasing educational level (P<0.05. There was a high willingness and intention among the mothers to vaccinate their girls (88.9% and to recommend the vaccine to others (91.0%. Accessibility and affordability of the HPV vaccines were found to be possible barriers to future utilization of the vaccines. Conclusion: Despite low knowledge about HPV and HPV vaccines, mothers were willing to vaccinate their daughters. We recommend improving mothers' knowledge by education and the possible inclusion of the vaccine in the national immunization

  19. Genome-wide genetic interaction analysis of glaucoma using expert knowledge derived from human phenotype networks.

    Science.gov (United States)

    Hu, Ting; Darabos, Christian; Cricco, Maria E; Kong, Emily; Moore, Jason H

    2015-01-01

    The large volume of GWAS data poses great computational challenges for analyzing genetic interactions associated with common human diseases. We propose a computational framework for characterizing epistatic interactions among large sets of genetic attributes in GWAS data. We build the human phenotype network (HPN) and focus around a disease of interest. In this study, we use the GLAUGEN glaucoma GWAS dataset and apply the HPN as a biological knowledge-based filter to prioritize genetic variants. Then, we use the statistical epistasis network (SEN) to identify a significant connected network of pairwise epistatic interactions among the prioritized SNPs. These clearly highlight the complex genetic basis of glaucoma. Furthermore, we identify key SNPs by quantifying structural network characteristics. Through functional annotation of these key SNPs using Biofilter, a software accessing multiple publicly available human genetic data sources, we find supporting biomedical evidences linking glaucoma to an array of genetic diseases, proving our concept. We conclude by suggesting hypotheses for a better understanding of the disease.

  20. Multiple choice exams of medical knowledge with open books and web access? A validity study

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Simonsen, Eivind Ortind; Knudsen, Ulla Breth

    2015-01-01

    Background: Open book tests have been suggested to lower test anxiety and promote deeper learning strategies. In the Aarhus University medical program, ¼ of the curriculum assess students’ medical knowledge with ‘open book, open web’ (OBOW) multiple choice examinations. We found little existing...... evidence about the validity of OBOW multiple choice exams of medical knowledge. Based on modern validity theory, we find the most problematic validity assumptions in this setting to be related to ‘extrapolation’ and ‘decision’, i.e.: to the assumptions that: 1) the test tasks require the competencies...... developed in the course, and 2) there are no skill-irrelevant sources of variability (e.g. information seeking skills) which bias the interpretation of test scores as measures of level of subject expertise), and 3) students with no/very low levels of subject expertise will not pass this test and progress...

  1. Making Gazes Explicit: Facilitating Epistemic Access in the Humanities

    Science.gov (United States)

    Luckett, Kathy; Hunma, Aditi

    2014-01-01

    This paper addresses the problem of curriculum design in the Humanities and Social Sciences, and more specifically the challenge of designing foundation courses for first-generation or "disadvantaged" learners. Located in the social realist school of the sociology of education studies that builds on the legacy of Basil Bernstein, we…

  2. Human Right and Internet Access : A philosophical investigation

    NARCIS (Netherlands)

    Wang, Xiaowei

    2016-01-01

    As of December 2014, there are three billion Internet users worldwide, of which 649 million are Chinese. This number will grow in the years to come. This technology, of course, possesses immense significance in our everyday life. What is currently new in international human rights practice is the tr

  3. Human rights & intellectual property for universal access to new essential medicines

    NARCIS (Netherlands)

    Perehudoff, Katrina; 't Hoen, Elisabeth; Babar, Zaheer

    2018-01-01

    This chapter illustrates how human rights principles can help governments, even those with the most modest budgets, scale-up universal access to expensive essential medicines. The key message is that governments have legally binding human rights obligations to immediately take steps to provide

  4. DOCUMENTING OF THE PROCESS OF ACCUMULATION OF KNOWLEDGE AND DEVELOPMENT OF THE INTELLECTUAL HUMAN CAPITAL

    Directory of Open Access Journals (Sweden)

    Yermolenko V. V.

    2015-06-01

    Full Text Available The problem of documenting of process of accumulation of knowledge and development of the intellectual human capital is considered in this article. The purpose of the article is the research of theoretical approaches of documenting of process of accumulation of knowledge, development of the intellectual human capital and the analysis of domestic public corporations on documenting of process of accumulation of knowledge. The solution of research tasks in article is proposed: the analysis of the contents of theories of development of the human capital in the conditions of economy of knowledge is carried out; domestic practice of public corporations on documenting of process of accumulation of knowledge is studied; features of documenting of knowledge as maintenance of development of the human capital are marked out. The particular emphasis in the article is placed on disclosure of such problems, as: methodological and theoretical aspects of development of the intellectual human capital; formation of mechanisms and ways of documenting of knowledge in the conditions of knowledge economy; formation of corporate institutes of formation and the development of the intellectual human capital, realizing reproduction of the intellectual capital and engineering of knowledge; formation of organizational innovations and dumping of old organizational routines. Documenting of knowledge is presented as maintenance of development of the human capital, the project of introduction of knowledge management and its documentary maintenance in corporations, and also ways of network documenting of knowledge of the human capital in the process of joint design activity is offered. Development of a special control system and its organizational and methodical providing which will allow to increase efficiency of work with documents during projects of development of the intellectual human capital is necessary for management of the documentary massif of knowledge of the

  5. Cyberscience and the Knowledge-Based Economy. Open Access and Trade Publishing: From Contradiction to Compatibility with Non-Exclusive Copyright Licensing

    Science.gov (United States)

    Armbruster, Chris

    2008-01-01

    Open source, open content and open access are set to fundamentally alter the conditions of knowledge production and distribution. Open source, open content and open access are also the most tangible result of the shift towards e-science and digital networking. Yet, widespread misperceptions exist about the impact of this shift on knowledge…

  6. Knowledge sharing in global health research - the impact, uptake and cost of open access to scholarly literature.

    Science.gov (United States)

    Smith, Elise; Haustein, Stefanie; Mongeon, Philippe; Shu, Fei; Ridde, Valéry; Larivière, Vincent

    2017-08-29

    In 1982, the Annals of Virology published a paper showing how Liberia has a highly endemic potential of Ebola warning health authorities of the risk for potential outbreaks; this journal is only available by subscription. Limiting the accessibility of such knowledge may have reduced information propagation toward public health actors who were indeed surprised by and unprepared for the 2014 epidemic. Open access (OA) publication can allow for increased access to global health research (GHR). Our study aims to assess the use, cost and impact of OA diffusion in the context of GHR. A total of 3366 research articles indexed under the Medical Heading Subject Heading "Global Health" published between 2010 and 2014 were retrieved using PubMed to (1) quantify the uptake of various types of OA, (2) estimate the article processing charges (APCs) of OA, and (3) analyse the relationship between different types of OA, their scholarly impact and gross national income per capita of citing countries. Most GHR publications are not available directly on the journal's website (69%). Further, 60.8% of researchers do not self-archive their work even when it is free and in keeping with journal policy. The total amount paid for APCs was estimated at US$1.7 million for 627 papers, with authors paying on average US$2732 per publication; 94% of APCs were paid to journals owned by the ten most prominent publication houses from high-income countries. Researchers from low- and middle-income countries are generally citing less expensive types of OA, while researchers in high-income countries are citing the most expensive OA. Although OA may help in building global research capacity in GHR, the majority of publications remain subscription only. It is logical and cost-efficient for institutions and researchers to promote OA by self-archiving publications of restricted access, as it not only allows research to be cited by a broader audience, it also augments citation rates. Although OA does not

  7. Evaluation of endoscopy in localizing transgastric access for natural orifice transluminal endoscopic surgery in humans.

    Science.gov (United States)

    Linke, Georg R; Zerz, Andreas; Kapitza, Florian; Warschkow, Rene; Lange, Jochen; Meyenberger, Christa M; Binek, Janek

    2010-05-01

    To date, transgastric access in humans for natural orifice transluminal endoscopic surgery (NOTES) has been poorly evaluated. To compare endoscopic visualization of the transgastric access point with the laparoscopically defined ideal entrance to the peritoneal cavity. Prospective pilot study in humans. Single tertiary-care center. This study involved 31 patients referred for laparoscopic cholecystectomy. Access points were marked by endoscopy alone, endoscopy combined with diaphanoscopy, and endoscopy after pneumoperitoneum. Points were correlated with a laparoscopically visualized, previously defined ideal access area. To choose the appropriate access point within the laparoscopically defined ideal access area to the peritoneal cavity away from major vessels and adjacent organs, by using endoscopy and to establish landmarks for the endoscopist, look for a learning curve, and identify potential problems. The percentage of access points within the laparoscopically defined ideal area was 35.5% with endoscopy alone, 13.8% using the diaphanoscopy method, and 45.2% after transcutaneous pneumoperitoneum. A safe access point (> or = 3 cm from major gastric vessels) could be achieved with the 3 techniques in 83.9%, 65.5%, and 87.1% of patients, respectively. A positive learning curve for endoscopic localization was identified before (P = .008) and after (P = .014) pneumoperitoneum. Virtual complications were greater in obese patients. This was a small pilot study with hypothetical complications and problems, because actual transgastric access was not performed. The criteria for an ideal access area were very strict. Endoscopy, especially with the use of pneumoperitoneum, can reliably locate a safe transgastric entrance point. However, the endoscopically chosen site correlates poorly with the ideal laparoscopically determined site for transgastric access. 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  8. Semi-Automatically Extracting FAQs to Improve Accessibility of Software Development Knowledge

    CERN Document Server

    Henß, Stefan; Mezini, Mira

    2012-01-01

    Frequently asked questions (FAQs) are a popular way to document software development knowledge. As creating such documents is expensive, this paper presents an approach for automatically extracting FAQs from sources of software development discussion, such as mailing lists and Internet forums, by combining techniques of text mining and natural language processing. We apply the approach to popular mailing lists and carry out a survey among software developers to show that it is able to extract high-quality FAQs that may be further improved by experts.

  9. Knowledge and acceptability of human papillomavirus vaccination and cervical cancer screening among women in Karnataka, India.

    Science.gov (United States)

    Montgomery, Martha P; Dune, Tanaka; Shetty, Prasanna K; Shetty, Avinash K

    2015-03-01

    Cervical cancer is the leading cause of cancer-related mortality among women in India; however, participation in prevention and screening is low and the reasons for this are not well understood. In a cross-sectional survey in August 2008, 202 healthy women in Karnataka, India completed a questionnaire regarding knowledge, attitudes, and practices related to human papillomavirus (HPV) and cervical cancer. Factors associated with vaccination and Papanicolau (Pap) smear screening acceptance were explored. Thirty-six percent of women had heard of HPV while 15% had heard of cervical cancer. Five percent of women reported ever having a Pap smear, and 4% of women felt at risk of HPV infection. Forty-six percent of women were accepting of vaccination, but fewer (21%) were willing to have a Pap smear. Overall, knowledge related to HPV and cervical cancer topics was low. Women with negative attitudes toward HPV infection were 5.3 (95% confidence interval (CI) 2.8-10) times more likely to accept vaccination but were not significantly more likely to accept Pap smear (odds ratio 1.5, 95% CI 0.7-3.0). Cost and a low level of perceived risk were the most frequent factors cited as potential barriers. Improving awareness of HPV and cervical cancer through health care providers in addition to increasing access to vaccination and screening through government-sponsored programs may be feasible and effective methods to reduce cervical cancer burden in India.

  10. Organizing conceptual knowledge in humans with a gridlike code

    NARCIS (Netherlands)

    Constantinescu, A.O.; O'Reilly, J.X.; Behrens, T.E.J.

    2016-01-01

    Grid cells are thought to provide the neuronal code that underlies spatial knowledge in the brain. Grid cells have mostly been studied in the context of path integration. However, recent theoretical studies have suggested that they may have a broader role in the organization of general knowledge. Co

  11. Organizing conceptual knowledge in humans with a gridlike code

    NARCIS (Netherlands)

    Constantinescu, A.O.; O'Reilly, J.X.; Behrens, T.E.J.

    2016-01-01

    Grid cells are thought to provide the neuronal code that underlies spatial knowledge in the brain. Grid cells have mostly been studied in the context of path integration. However, recent theoretical studies have suggested that they may have a broader role in the organization of general knowledge.

  12. Consumers’ perception and knowledge of food safety: results of questionnaires accessible on IZSalimenTO website

    Directory of Open Access Journals (Sweden)

    Amaranta Traversa

    2015-04-01

    Full Text Available The present survey was undertaken to investigate consumers’ knowledge of the main foodborne agents and dietary regimen during pregnancy. Data were collected using monthly questionnaires available on IZSalimenTO website between March 2013 and January 2014. Hepatitis A virus questionnaire: 20 respondents (77% recognized berries as foodstuff linked to the outbreak of hepatitis A. The majority correctly indicated as precautionary advice to boil berries before consumption. Botulism questionnaire: 29 respondents (62% indicated pesto as food involved in botulism alert in July 2013. The risk of infant botulism in infant less than 1 year old due to honey consumption is known by 24 respondents (51%. Main foodborne disease questionnaire: the risk of infection by Salmonella after the consumption of foods made with raw eggs is known by the majority (94%; N=17 as well as the treatments to be applied in order to make fresh fish safe from parasites (76%. Pregnancy questionnaire: 20 respondents (74% believed that washing vegetables and fruits with sodium bicarbonate or chlorate solution is able to inactivate Toxoplasma; only 4 (15% reported both raw meat and vegetables washed with sodium bicarbonate as food at risk. Results indicate that all consumers should be trained on behaviour and dietary regimen to be adopted in pregnancy and in infant <1 year old. The website may be considered as a useful tool to assess consumers’ knowledge: both the news section and the contents published may be a source of information and education for consumers on food safety.

  13. Accessing Local Knowledge to Identify Where Species of Conservation Concern Occur in a Tropical Forest Landscape

    Science.gov (United States)

    Padmanaba, Michael; Sheil, Douglas; Basuki, Imam; Liswanti, Nining

    2013-08-01

    Conventional biodiversity surveys play an important role in ensuring good conservation friendly management in tropical forest regions but are demanding in terms of expertise, time, and budget. Can local people help? Here, we illustrate how local knowledge can support low cost conservation surveys. We worked in the Malinau watershed, East Kalimantan, Indonesia, an area currently at risk of extensive forest loss. We selected eight species of regional conservation interest: rafflesia ( Rafflesia spp.), black orchid ( Coelogyne pandurata), sun bear ( Helarctos malayanus), tarsier ( Tarsius bancanus), slow loris ( Nycticebus coucang), proboscis monkey ( Nasalis larvatus), clouded leopard ( Neofelis diardi/N. nebulosa), and orang-utan ( Pongo pygmaeus). We asked 52 informants in seven villages if, where and when they had observed these species. We used maps, based on both geo-referenced and sketched features, to record these observations. Verification concerns and related issues are discussed. Evaluations suggest our local information is reliable. Our study took 6 weeks and cost about USD 5000. Extensive expert based field surveys across the same region would cost one or two orders of magnitude more. The records extend the known distribution for sun bear, tarsier, slow loris, and clouded leopard. Reports of rafflesia, proboscis monkey, and orang-utan are of immediate conservation significance. While quality concerns should never be abandoned, we conclude that local people can help expand our knowledge of large areas in an effective, reliable, and low cost manner and thus contribute to improved management.

  14. Accessing local knowledge to identify where species of conservation concern occur in a tropical forest landscape.

    Science.gov (United States)

    Padmanaba, Michael; Sheil, Douglas; Basuki, Imam; Liswanti, Nining

    2013-08-01

    Conventional biodiversity surveys play an important role in ensuring good conservation friendly management in tropical forest regions but are demanding in terms of expertise, time, and budget. Can local people help? Here, we illustrate how local knowledge can support low cost conservation surveys. We worked in the Malinau watershed, East Kalimantan, Indonesia, an area currently at risk of extensive forest loss. We selected eight species of regional conservation interest: rafflesia (Rafflesia spp.), black orchid (Coelogyne pandurata), sun bear (Helarctos malayanus), tarsier (Tarsius bancanus), slow loris (Nycticebus coucang), proboscis monkey (Nasalis larvatus), clouded leopard (Neofelis diardi/N. nebulosa), and orang-utan (Pongo pygmaeus). We asked 52 informants in seven villages if, where and when they had observed these species. We used maps, based on both geo-referenced and sketched features, to record these observations. Verification concerns and related issues are discussed. Evaluations suggest our local information is reliable. Our study took 6 weeks and cost about USD 5000. Extensive expert based field surveys across the same region would cost one or two orders of magnitude more. The records extend the known distribution for sun bear, tarsier, slow loris, and clouded leopard. Reports of rafflesia, proboscis monkey, and orang-utan are of immediate conservation significance. While quality concerns should never be abandoned, we conclude that local people can help expand our knowledge of large areas in an effective, reliable, and low cost manner and thus contribute to improved management.

  15. Employing human rights frameworks to realize access to an HIV cure.

    Science.gov (United States)

    Meier, Benjamin Mason; Gelpi, Adriane; Kavanagh, Matthew M; Forman, Lisa; Amon, Joseph J

    2015-01-01

    The scale of the HIV pandemic - and the stigma, discrimination and violence that surrounded its sudden emergence - catalyzed a public health response that expanded human rights in principle and practice. In the absence of effective treatment, human rights activists initially sought to protect individuals at high risk of HIV infection. With advances in antiretroviral therapy, activists expanded their efforts under international law, advocating under the human right to health for individual access to treatment. As a clinical cure comes within reach, human rights obligations will continue to play a key role in political and programmatic decision-making. Building upon the evolving development and implementation of the human right to health in the global response to HIV, we outline a human rights research agenda to prepare for HIV cure access, investigating the role of human rights law in framing 1) resource allocation, 2) international obligations, 3) intellectual property and 4) freedom from coercion. The right to health is widely recognized as central to governmental, intergovernmental and non-governmental responses to the pandemic and critical both to addressing vulnerability to infection and to ensuring universal access to HIV prevention, treatment, care and support. While the advent of an HIV cure will raise new obligations for policymakers in implementing the right to health, the resolution of past debates surrounding HIV prevention and treatment may inform claims for universal access.

  16. Employing human rights frameworks to realize access to an HIV cure

    Directory of Open Access Journals (Sweden)

    Benjamin Mason Meier

    2015-11-01

    Full Text Available Introduction: The scale of the HIV pandemic – and the stigma, discrimination and violence that surrounded its sudden emergence – catalyzed a public health response that expanded human rights in principle and practice. In the absence of effective treatment, human rights activists initially sought to protect individuals at high risk of HIV infection. With advances in antiretroviral therapy, activists expanded their efforts under international law, advocating under the human right to health for individual access to treatment. Discussion: As a clinical cure comes within reach, human rights obligations will continue to play a key role in political and programmatic decision-making. Building upon the evolving development and implementation of the human right to health in the global response to HIV, we outline a human rights research agenda to prepare for HIV cure access, investigating the role of human rights law in framing 1 resource allocation, 2 international obligations, 3 intellectual property and 4 freedom from coercion. Conclusions: The right to health is widely recognized as central to governmental, intergovernmental and non-governmental responses to the pandemic and critical both to addressing vulnerability to infection and to ensuring universal access to HIV prevention, treatment, care and support. While the advent of an HIV cure will raise new obligations for policymakers in implementing the right to health, the resolution of past debates surrounding HIV prevention and treatment may inform claims for universal access.

  17. Implications of Human Pattern Processing for the Design of Artificial Knowledge Systems.

    Science.gov (United States)

    Hayes-Roth, Barbara

    This paper presents evidence that four design principles commonly embodied in artificial knowledge systems are inconsistent with human cognitive capabilities. Because these principles are widely accepted as characteristics of human knowledge processing, common theoretical properties related to cognitive psychology and artificial intelligence which…

  18. Teenagers’ knowledge of human sexuality and their views on teenage pregnancies

    Directory of Open Access Journals (Sweden)

    P. J. Kunene

    1995-05-01

    Full Text Available There is concern about poor knowledge of human sexuality and a high rate of teenage pregnancies among Blacks. The primary aim of the study was to measure the knowledge that teenagers have on human sexuality and to identify the sources from which they obtain such knowledge. The secondary aim was to detect how teenagers perceive the teenage pregnancy problem and its consequences,

  19. Human transporter database: comprehensive knowledge and discovery tools in the human transporter genes.

    Directory of Open Access Journals (Sweden)

    Adam Y Ye

    Full Text Available Transporters are essential in homeostatic exchange of endogenous and exogenous substances at the systematic, organic, cellular, and subcellular levels. Gene mutations of transporters are often related to pharmacogenetics traits. Recent developments in high throughput technologies on genomics, transcriptomics and proteomics allow in depth studies of transporter genes in normal cellular processes and diverse disease conditions. The flood of high throughput data have resulted in urgent need for an updated knowledgebase with curated, organized, and annotated human transporters in an easily accessible way. Using a pipeline with the combination of automated keywords query, sequence similarity search and manual curation on transporters, we collected 1,555 human non-redundant transporter genes to develop the Human Transporter Database (HTD (http://htd.cbi.pku.edu.cn. Based on the extensive annotations, global properties of the transporter genes were illustrated, such as expression patterns and polymorphisms in relationships with their ligands. We noted that the human transporters were enriched in many fundamental biological processes such as oxidative phosphorylation and cardiac muscle contraction, and significantly associated with Mendelian and complex diseases such as epilepsy and sudden infant death syndrome. Overall, HTD provides a well-organized interface to facilitate research communities to search detailed molecular and genetic information of transporters for development of personalized medicine.

  20. Human transporter database: comprehensive knowledge and discovery tools in the human transporter genes.

    Science.gov (United States)

    Ye, Adam Y; Liu, Qing-Rong; Li, Chuan-Yun; Zhao, Min; Qu, Hong

    2014-01-01

    Transporters are essential in homeostatic exchange of endogenous and exogenous substances at the systematic, organic, cellular, and subcellular levels. Gene mutations of transporters are often related to pharmacogenetics traits. Recent developments in high throughput technologies on genomics, transcriptomics and proteomics allow in depth studies of transporter genes in normal cellular processes and diverse disease conditions. The flood of high throughput data have resulted in urgent need for an updated knowledgebase with curated, organized, and annotated human transporters in an easily accessible way. Using a pipeline with the combination of automated keywords query, sequence similarity search and manual curation on transporters, we collected 1,555 human non-redundant transporter genes to develop the Human Transporter Database (HTD) (http://htd.cbi.pku.edu.cn). Based on the extensive annotations, global properties of the transporter genes were illustrated, such as expression patterns and polymorphisms in relationships with their ligands. We noted that the human transporters were enriched in many fundamental biological processes such as oxidative phosphorylation and cardiac muscle contraction, and significantly associated with Mendelian and complex diseases such as epilepsy and sudden infant death syndrome. Overall, HTD provides a well-organized interface to facilitate research communities to search detailed molecular and genetic information of transporters for development of personalized medicine.

  1. The Relationship between Humanness and Knowledge Sharing in Malaysia Empirical Evidence from Malaysian Managers

    Directory of Open Access Journals (Sweden)

    Ilona H. Boom

    2012-05-01

    Full Text Available This paper explores whether there is a relationship between humanness and the willingness to share knowledge in Malaysia. Furthermore, the differences between the Malay, Chinese and Indian ethnicities are researched for the presence of humanness and the willingness to share knowledge. Two hundred and fourteen respondents from privately owned companies participated in this research showing that there is a strong relationship between humanness and knowledge sharing. However, the differences between the three ethnicities are small, which is a surprising finding. It can be concluded that people-oriented managers (one of the ways to express humanness are more willing to share knowledge, and differences between ethnicities have no influence in this matter. From these results, it can be recommended to managers and organizations in Malaysia that they pay more attention and be aware of their management style.Stressing the humanness aspects more as they are described could improve the knowledge transfer within companies.

  2. Novel and direct access to the human locomotor spinal circuitry.

    Science.gov (United States)

    Gerasimenko, Yury; Gorodnichev, Ruslan; Machueva, Ekaterina; Pivovarova, Elena; Semyenov, Denis; Savochin, Alexandr; Roy, Roland R; Edgerton, V Reggie

    2010-03-10

    The degree of automaticity of locomotion in primates compared with other mammals remains unclear. Here, we examine the possibility for activation of the spinal locomotor circuitry in noninjured humans by spinal electromagnetic stimulation (SEMS). SEMS (3 Hz and 1.3-1.82 tesla) at the T11-T12 vertebrae induced involuntary bilateral locomotor-like movements in the legs of individuals placed in a gravity-neutral position. The formation of locomotor-like activity during SEMS started with a latency of 0.68 +/- 0.1 s after delivering the first stimulus, unlike continuous vibration of muscles, which requires several seconds. The first EMG burst in response to SEMS was observed most often in a proximal flexor muscle. We speculate that SEMS directly activates the circuitry intrinsic to the spinal cord, as suggested by the immediate response and the electrophysiological observations demonstrating an absence of strictly time-linked responses within the EMG burst associated with individual stimuli during SEMS. SEMS in the presence of vibration of the leg muscles was more effective in facilitating locomotor-like activity than SEMS alone. The present results suggest that SEMS could be an effective noninvasive clinical tool to determine the potential of an individual to recover locomotion after a spinal cord injury, as well as being an effective rehabilitation tool itself.

  3. Human Instruments: Accessible Musical Instruments for People with Varied Physical Ability.

    Science.gov (United States)

    Matossian, Vahakn; Gehlhaar, Rolf

    2015-01-01

    There are few ways in which persons, who do not have the use of their hands or arms, are able make music or control complex computer systems. Music as an expressive output is key to the full development of the human mind. Human Instruments is dedicated to the development and production of accessible musical instruments playable at a professional level, as well as computer control interfaces. We are currently user-testing three new, uniquely accessible devices, for their effectiveness in expressive music creation. Preliminary results are compelling.

  4. Addressing the concerns of rural communities about access to plants and knowledge in a sui generis legislation in Cameroon

    Indian Academy of Sciences (India)

    Marcelin Tonye Mahop

    2004-12-01

    This article assesses the traditional systems of accessing and using plant genetic resources as well as the benefit sharing and systems of sanctioning infringement in the context of biodiversity related activities in specific areas in the Northwest province of Cameroon. The article also addresses the type research and development activities using plant genetic resources and associated traditional knowledge in the context of Cameroon, the current laws regulating such activities and the extent to which these activities and laws affect and/or protect the customary biodiversity rights of rural communities. The article uses these assessments to suggest the context under which a sui generis legislation for the protection of the biodiversity rights of rural communities can be established in Cameroon.

  5. Traditional Knowledge in the Time of Neo-Liberalism: Access and Benefit-Sharing Regimes in India and Bhutan

    Directory of Open Access Journals (Sweden)

    Indrani Barpujari

    2017-03-01

    Full Text Available In a neoliberal world, traditional knowledge (TK of biodiversity possessed by Indigenous and Local Communities (ILCs in the global South has become a valuable "commodity" or "bio-resource," necessitating the setting up of harmonized ground rules (international and national in the form of an access and benefitsharing regime to facilitate its exchange in the world market. Despite criticisms that a regime with a neo-liberal orientation is antithetical to the normative ethos of ILCs, it could also offer a chance for developing countries and ILCs to generate revenue for socioeconomic development—to which they are gradually becoming open, but only under fair and equitable terms. Based on this context, this article proposes to look into the legal and policy frameworks and institutional regimes governing access and benefit sharing of TK associated with biological resources in two countries of South Asia: India and Bhutan. The article seeks to examine how such regimes are reconciling the imperatives of a neo-liberal economy with providing a just and equitable framework for ILCs and TK holders, which is truly participatory and not top-down.

  6. Reconstructing Sessions from Data Discovery and Access Logs to Build a Semantic Knowledge Base for Improving Data Discovery

    Directory of Open Access Journals (Sweden)

    Yongyao Jiang

    2016-04-01

    Full Text Available Big geospatial data are archived and made available through online web discovery and access. However, finding the right data for scientific research and application development is still a challenge. This paper aims to improve the data discovery by mining the user knowledge from log files. Specifically, user web session reconstruction is focused upon in this paper as a critical step for extracting usage patterns. However, reconstructing user sessions from raw web logs has always been difficult, as a session identifier tends to be missing in most data portals. To address this problem, we propose two session identification methods, including time-clustering-based and time-referrer-based methods. We also present the workflow of session reconstruction and discuss the approach of selecting appropriate thresholds for relevant steps in the workflow. The proposed session identification methods and workflow are proven to be able to extract data access patterns for further pattern analyses of user behavior and improvement of data discovery for more relevancy data ranking, suggestion, and navigation.

  7. Digital Accessible Knowledge and well-inventoried sites for birds in Mexico: baseline sites for measuring faunistic change

    Directory of Open Access Journals (Sweden)

    A. Townsend Peterson

    2016-09-01

    Full Text Available Background Faunal change is a basic and fundamental element in ecology, biogeography, and conservation biology, yet vanishingly few detailed studies have documented such changes rigorously over decadal time scales. This study responds to that gap in knowledge, providing a detailed analysis of Digital Accessible Knowledge of the birds of Mexico, designed to marshal DAK to identify sites that were sampled and inventoried rigorously prior to the beginning of major global climate change (1980. Methods We accumulated DAK records for Mexican birds from all relevant online biodiversity data portals. After extensive cleaning steps, we calculated completeness indices for each 0.05° pixel across the country; we also detected ‘hotspots’ of sampling, and calculated completeness indices for these broader areas as well. Sites were designated as well-sampled if they had completeness indices above 80% and >200 associated DAK records. Results We identified 100 individual pixels and 20 broader ‘hotspots’ of sampling that were demonstrably well-inventoried prior to 1980. These sites are catalogued and documented to promote and enable resurvey efforts that can document events of avifaunal change (and non-change across the country on decadal time scales. Conclusions Development of repeated surveys for many sites across Mexico, and particularly for sites for which historical surveys document their avifaunas prior to major climate change processes, would pay rich rewards in information about distributional dynamics of Mexican birds.

  8. Cervical Cancer and Human Papilloma Virus Knowledge and ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    is a global public health issue as it is the second most common ... HPV infection and its relation to cervical cancer. Some previous ..... obtained their knowledge mostly from the media ... findings from a study carried out in India where. 82% of ...

  9. Book review: Pragmatic humanism: on the nature and value of sociological knowledge by Marcus Morgan

    OpenAIRE

    2016-01-01

    In Pragmatic Humanism: On the Nature and Value of Sociological Knowledge, Marcus Morgan positions sociology not as a science of society, but as a discipline of humanity. Rather than resurrect a problematic, classical conception of humanism, Morgan instead engages with past and contemporary critiques of humanist thought to position humanism as a pragmatic approach to sociology that draws on human action as a tool for progressive social change. Adam Carter heartily recommends this invigorating ...

  10. Knowledges

    DEFF Research Database (Denmark)

    Berling, Trine Villumsen

    2012-01-01

    and reflectivism. Bourdieu, on the contrary, lets the challenge to the theory/reality distinction spill over into a challenge to the theory/practice distinction by thrusting the scientist in the foreground as not just a factor (discourse/genre) but as an actor. In this way, studies of IR need to include a focus......Scientific knowledge in international relations has generally focused on an epistemological distinction between rationalism and reflectivism over the last 25 years. This chapter argues that this distinction has created a double distinction between theory/reality and theory/practice, which works...... as a ghost distinction structuring IR research. While reflectivist studies have emphasised the impossibility of detached, objective knowledge production through a dissolution of the theory/reality distinction, the theory/practice distinction has been left largely untouched by both rationalism...

  11. Human security and access to water, sanitation, and hygiene: exploring the drivers and nexus

    NARCIS (Netherlands)

    P. Obani; J. Gupta

    2016-01-01

    Water security challenges are mostly covered in the literature on the food and energy nexus. This chapter however adopts a broader conception of water security in relation to lack of access to water, sanitation, and hygiene (WASH), and argues that the human rights approach could be instrumental in a

  12. Snag distributions in relation to human access in ponderosa pine forests

    Science.gov (United States)

    Jeff P. Hollenbeck; Lisa J. Bate; Victoria A. Saab; John F. Lehmkuhl

    2013-01-01

    Ponderosa pine (Pinus ponderosa) forests in western North America provide habitat for numerous cavity-using wildlife species that often select large-diameter snags for nesting and roosting. Yet large snags are often removed for their commercial and firewood values. Consequently we evaluated effects of human access on snag densities and diameter-class distributions at...

  13. Capital-centric versus knowledge-centric paradigms of human resource management: A historical perspective

    Directory of Open Access Journals (Sweden)

    Chris W. Callaghan

    2016-03-01

    Full Text Available Orientation: Central to understanding the contemporary state of the human resource management (HRM field is knowledge of its history, and the underlying rationales as to why it has changed over time. This research attempts to identify one such important ‘rationale’.Research purpose: This article relates certain changes in HRM over time to the argument that there has been a shift from an industrial paradigm (on which many human resource [HR] systems, practices and theoretical frameworks are still based to a knowledge paradigm (of knowledge work, in which employee knowledge and skills offer compound advantages that are not substitutable which explains a great deal of the variance in changes of the field over time.Motivation for the study: It is argued that in order for the field to move forward, it may needto bring to the surface certain assumptions and differentiate between theoretical frameworkswhen dealing with knowledge work versus non-knowledge work.Research design, approach and method: This article offers a perspective of HR theory development over time. It is a conceptual/perspectives article and is not qualitative nor quantitative in nature. Further research will be able to test the ideas presented here.Practical/managerial implications: Managers and human resources managers need to differentiate between knowledge and non-knowledge work. The latter is associated with increased heterogeneity and complexity, and differences in power relationships, as knowledge work shifts power away from capital into the hands of skilled knowledge labour.

  14. Knowledge-Intensive Entrepreneurship and the Impact of Human Capital

    DEFF Research Database (Denmark)

    Madsen, Henning; Neergaard, Helle; Ulhøi, John Parm

    2002-01-01

    The purpose of this paper is to address selected aspects of human capital in association with the entrepreneurial process in technology-based new ventures. Until recently, research investigating the founding of new businesses has mainly focused on the personal characteristics of entrepreneurs...... of a newly founded venture. Furthermore, the dimensions of human capital, experience and previous employment, seem to be essential in building the networks that help secure both the early as well as a continuous pool of finance for the ventures....

  15. Knowledge-based personalized search engine for the Web-based Human Musculoskeletal System Resources (HMSR) in biomechanics.

    Science.gov (United States)

    Dao, Tien Tuan; Hoang, Tuan Nha; Ta, Xuan Hien; Tho, Marie Christine Ho Ba

    2013-02-01

    Human musculoskeletal system resources of the human body are valuable for the learning and medical purposes. Internet-based information from conventional search engines such as Google or Yahoo cannot response to the need of useful, accurate, reliable and good-quality human musculoskeletal resources related to medical processes, pathological knowledge and practical expertise. In this present work, an advanced knowledge-based personalized search engine was developed. Our search engine was based on a client-server multi-layer multi-agent architecture and the principle of semantic web services to acquire dynamically accurate and reliable HMSR information by a semantic processing and visualization approach. A security-enhanced mechanism was applied to protect the medical information. A multi-agent crawler was implemented to develop a content-based database of HMSR information. A new semantic-based PageRank score with related mathematical formulas were also defined and implemented. As the results, semantic web service descriptions were presented in OWL, WSDL and OWL-S formats. Operational scenarios with related web-based interfaces for personal computers and mobile devices were presented and analyzed. Functional comparison between our knowledge-based search engine, a conventional search engine and a semantic search engine showed the originality and the robustness of our knowledge-based personalized search engine. In fact, our knowledge-based personalized search engine allows different users such as orthopedic patient and experts or healthcare system managers or medical students to access remotely into useful, accurate, reliable and good-quality HMSR information for their learning and medical purposes.

  16. Retaking Responsibility for How We Communicate. A Review of Open Access and the Humanities: Contexts, Controversies and the Future

    Directory of Open Access Journals (Sweden)

    James Baker

    2015-06-01

    Full Text Available Since the publication of the Budapest Open Access Initiative statement in 2002, Open Access has grown from an ideal to a reality. Open Access and the Humanities explores scholarly practices, communications, and cultures in light of this change and argues that humanists can and should retake responsibility for how they chose to publish.

  17. Knowledge assessment of Cienfuegos´ health workers on human toxocariasis.

    Directory of Open Access Journals (Sweden)

    Martina S. Jiménez Suárez

    2008-08-01

    Full Text Available Background: Human toxocariasis is one of the most worldwide extended zoonosis. It mainly affects children and it is not always well known by medical staff. Objective: To assess knowledge of Cienfuegos´s health workers on human toxocariasis. Method: A descriptive cross-sectional study was developed from May to September 2005 and a survey was applied to a total sample of 51 doctors through a randomized, stratified sampling. In addition to consider professional category, years of experience and knowledge on zoonosis, we analyzed different aspects the form the variable general knowledge on human toxocariasis. Findings: We could develop a knowledge assessment on toxocariasis in Cienfuegos´ doctors. These findings were compared with surveys in other countries. There is not history of this kind of research in Cuba. Conclusions: Cienfuegos´ doctors knowledge on toxocariasis diagnosis, transmission, and prevention and not satisfactory except for clinic and treatment.

  18. Classifying a Person's Degree of Accessibility From Natural Body Language During Social Human-Robot Interactions.

    Science.gov (United States)

    McColl, Derek; Jiang, Chuan; Nejat, Goldie

    2017-02-01

    For social robots to be successfully integrated and accepted within society, they need to be able to interpret human social cues that are displayed through natural modes of communication. In particular, a key challenge in the design of social robots is developing the robot's ability to recognize a person's affective states (emotions, moods, and attitudes) in order to respond appropriately during social human-robot interactions (HRIs). In this paper, we present and discuss social HRI experiments we have conducted to investigate the development of an accessibility-aware social robot able to autonomously determine a person's degree of accessibility (rapport, openness) toward the robot based on the person's natural static body language. In particular, we present two one-on-one HRI experiments to: 1) determine the performance of our automated system in being able to recognize and classify a person's accessibility levels and 2) investigate how people interact with an accessibility-aware robot which determines its own behaviors based on a person's speech and accessibility levels.

  19. The Human Genome Project: Information access, management, and regulation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    McInerney, J.D.; Micikas, L.B.

    1996-08-31

    The Human Genome Project is a large, internationally coordinated effort in biological research directed at creating a detailed map of human DNA. This report describes the access of information, management, and regulation of the project. The project led to the development of an instructional module titled The Human Genome Project: Biology, Computers, and Privacy, designed for use in high school biology classes. The module consists of print materials and both Macintosh and Windows versions of related computer software-Appendix A contains a copy of the print materials and discs containing the two versions of the software.

  20. Men's Perceptions and Knowledge of Human Papillomavirus (HPV) Infection and Cervical Cancer

    Science.gov (United States)

    McPartland, Tara S.; Weaver, Bethany A.; Lee, Shu-Kuang; Koutsky, Laura A.

    2005-01-01

    The authors assessed young men's knowledge and perceptions of genital human papillomavirus (HPV) infection to identify factors that predict intention to make positive behavioral changes. Male university students aged 18 to 25 years completed a self-report instrument to assess knowledge and perceptions of genital HPV infection. If diagnosed with…

  1. Knowledge of Acute Human Immnuodeficiency Virus Infection among Gay and Bisexual Male College Students

    Science.gov (United States)

    Grin, Benjamin; Chan, Philip A.; Operario, Don

    2013-01-01

    Objective: To examine human immunodeficiency virus (HIV)-related knowledge, attitudes, and behaviors in at-risk college men who have sex with men (MSM), focusing on knowledge about acute HIV infection (AHI). Participants and Methods: A one-time anonymous survey was administered to college students attending a lesbian, gay, bisexual, transgender,…

  2. Knowledge, Attitudes, and Informational Behaviors of College Students in Regard to the Human Papillomavirus

    Science.gov (United States)

    Sandfort, Jessica R.; Pleasant, Andrew

    2009-01-01

    Objective: To assess students' human papillomavirus (HPV) knowledge, attitudes, and behaviors. Participants/ Methods: Students (N = 1,282) at a large, public university in the Northeast United States completed a questionnaire during February 2008 assessing HPV knowledge, prevalence, transmission, cervical cancer risk and stigma; sexual behavior,…

  3. Men's Perceptions and Knowledge of Human Papillomavirus (HPV) Infection and Cervical Cancer

    Science.gov (United States)

    McPartland, Tara S.; Weaver, Bethany A.; Lee, Shu-Kuang; Koutsky, Laura A.

    2005-01-01

    The authors assessed young men's knowledge and perceptions of genital human papillomavirus (HPV) infection to identify factors that predict intention to make positive behavioral changes. Male university students aged 18 to 25 years completed a self-report instrument to assess knowledge and perceptions of genital HPV infection. If diagnosed with…

  4. The shaping of social perception by stimulus and knowledge cues to human animacy.

    Science.gov (United States)

    Cross, Emily S; Ramsey, Richard; Liepelt, Roman; Prinz, Wolfgang; de C Hamilton, Antonia F

    2016-01-19

    Although robots are becoming an ever-growing presence in society, we do not hold the same expectations for robots as we do for humans, nor do we treat them the same. As such, the ability to recognize cues to human animacy is fundamental for guiding social interactions. We review literature that demonstrates cortical networks associated with person perception, action observation and mentalizing are sensitive to human animacy information. In addition, we show that most prior research has explored stimulus properties of artificial agents (humanness of appearance or motion), with less investigation into knowledge cues (whether an agent is believed to have human or artificial origins). Therefore, currently little is known about the relationship between stimulus and knowledge cues to human animacy in terms of cognitive and brain mechanisms. Using fMRI, an elaborate belief manipulation, and human and robot avatars, we found that knowledge cues to human animacy modulate engagement of person perception and mentalizing networks, while stimulus cues to human animacy had less impact on social brain networks. These findings demonstrate that self-other similarities are not only grounded in physical features but are also shaped by prior knowledge. More broadly, as artificial agents fulfil increasingly social roles, a challenge for roboticists will be to manage the impact of pre-conceived beliefs while optimizing human-like design.

  5. Unspoken Knowledge: Implicit Learning of Structured Human Dance Movement

    Science.gov (United States)

    Opacic, Tajana; Stevens, Catherine; Tillmann, Barbara

    2009-01-01

    The sequencing of dance movements may be thought of as a grammar. We investigate implicit learning of regularities that govern sequences of unfamiliar, discrete dance movements. It was hypothesized that observers without prior experience with contemporary dance would be able to learn regularities that underpin structured human movement. Thirty-one…

  6. Unspoken Knowledge: Implicit Learning of Structured Human Dance Movement

    Science.gov (United States)

    Opacic, Tajana; Stevens, Catherine; Tillmann, Barbara

    2009-01-01

    The sequencing of dance movements may be thought of as a grammar. We investigate implicit learning of regularities that govern sequences of unfamiliar, discrete dance movements. It was hypothesized that observers without prior experience with contemporary dance would be able to learn regularities that underpin structured human movement. Thirty-one…

  7. Impact of human resources' knowledge and skills on SMEs' in Medan City, Indonesia

    OpenAIRE

    Sembiring, Rasmulia

    2016-01-01

    The purpose of this research article was to explore the influence of knowledge and skills of human resource on the performance of culinary Small and Medium Enterprises (SMEs) in Medan City, Indonesia. Using quantitative research design, data were collected from 120 culinary SMEs located in Medan City. Multiple regression, t-test and f-ratio were used to estimate the significant effect of human knowledge and skills partially or not, whereas F test was applied to test whether the effect will be...

  8. Access to state-held information as a fundamental right under the European Convention on Human Rights

    NARCIS (Netherlands)

    Hins, W.; Voorhoof, D.

    2007-01-01

    Access to state-held information essential in a democratic society - Traditional reluctance of the European Court of Human Rights to apply Article 10 European Convention on Human Rights in access to information cases - Positive obligations and new perspectives: initiatives within the Council of Euro

  9. Drawing on student knowledge in human anatomy and physiology

    Science.gov (United States)

    Slominski, Tara Nicole

    Prior to instruction, students may have developed alternative conceptions about the mechanics behind human physiology. To help students re-shape these ideas into correct reasoning, the faulty characteristics reinforcing the alternative conceptions need to made explicit. This study used student-generated drawings to expose alternative conceptions Human Anatomy and Physiology students had prior to instruction on neuron physiology. Specifically, we investigated how students thought about neuron communication across a synapse (n=355) and how neuron activity can be modified (n=311). When asked to depict basic communication between two neurons, at least 80% of students demonstrated incorrect ideas about synaptic transmission. When targeting spatial and temporal summation, only eleven students (3.5%) were able to accurately depict at least one form of summation. In response to both drawing questions, student drawings revealed multiple alternative conceptions that resulted in a deeper analysis and characterization of the wide variation of student ideas.

  10. Stabilizing knowledge through standards - A perspective for the humanities

    CERN Document Server

    Romary, Laurent

    2010-01-01

    It is usual to consider that standards generate mixed feelings among scientists. They are often seen as not really reflecting the state of the art in a given domain and a hindrance to scientific creativity. Still, scientists should theoretically be at the best place to bring their expertise into standard developments, being even more neutral on issues that may typically be related to competing industrial interests. Even if it could be thought of as even more complex to think about developping standards in the humanities, we will show how this can be made feasible through the experience gained both within the Text Encoding Initiative consortium and the International Organisation for Standardisation. By taking the specific case of lexical resources, we will try to show how this brings about new ideas for designing future research infrastructures in the human and social sciences.

  11. Using a knowledge elicitation method to specify the business model of a human factors organization

    NARCIS (Netherlands)

    Schraagen, J.M.C.; Ven, J. van de; Hoffman, R.R.; Moon, B.M.

    2009-01-01

    Concept Mapping was used to structure knowledge elicitation interviews with a group of human factors specialists whose goal was to describe the business model of their Department. This novel use of cognitive task analysis to describe the business model of a human factors organization resulted in a n

  12. Using a knowledge elicitation method to specify the business model of a human factors organization

    NARCIS (Netherlands)

    Schraagen, J.M.C.; Ven, J. van de; Hoffman, R.R.; Moon, B.M.

    2009-01-01

    Concept Mapping was used to structure knowledge elicitation interviews with a group of human factors specialists whose goal was to describe the business model of their Department. This novel use of cognitive task analysis to describe the business model of a human factors organization resulted in a n

  13. Using a knowledge elicitation method to specify the business model of a human factors organization.

    NARCIS (Netherlands)

    Schraagen, Johannes Martinus Cornelis; van de Ven, Josine; Hoffman, Robert R.; Moon, Brian M.

    2009-01-01

    Concept Mapping was used to structure knowledge elicitation interviews with a group of human factors specialists whose goal was to describe the business model of their Department. This novel use of cognitive task analysis to describe the business model of a human factors organization resulted in a n

  14. A virtual curtain for the detection of humans and access control

    OpenAIRE

    2010-01-01

    Biometrics has become a popular field for the development of techniques that aim at recognizing humans based upon one or more intrinsic physical or behavioral traits. In particular, many solutions dedicated to access control integrate biometric features like fingerprinting or face recognition. This paper describes a new method designed to interpret what happens when crossing an invisible vertical plane, called virtual curtain hereafter, at the footstep of a door frame. It relies on the use...

  15. Knowledge-Intensive Entrepreneurship and the Impact of Human Capital

    DEFF Research Database (Denmark)

    Madsen, Henning; Neergaard, Helle; Ulhøi, John Parm

    2002-01-01

    The purpose of this paper is to address selected aspects of human capital in association with the entrepreneurial process in technology-based new ventures. Until recently, research investigating the founding of new businesses has mainly focused on the personal characteristics of entrepreneurs......, but this trait approach tends to underestimate the extent to which crucial skills may be acquired. The preliminary findings presented in this paper indicate that it is not so much the inherent personality that is instrumental in founding and growing a new venture. Previous employments as well as entrepreneurial...... experiences are both considered to be critical to the entrepreneurial process, as they both seem to impact on new venture establishment. The longer the career path before venture founding, the more experience an entrepreneur has gathered. Therefore, age seems to have a positive influence on the success...

  16. HUMAN CAPITAL’S IMPACT ON THE PERFORMANCE OF ROMANIAN KNOWLEDGE BASED COMPANIES

    Directory of Open Access Journals (Sweden)

    Burja Camelia

    2012-12-01

    Full Text Available To meet the desiderata expressed by the implementation of knowledge-based economy, companies must reconsider development strategies and must facilitate the shift from a management largely based on resource consumption to knowledge-based management. In this view, the importance of the human factor increases, becoming a precious resource that creates value and competitiveness. This paper shows the interaction between company performance and human capital, exemplifying this aspect through a case study based on a regression model in Romanian software companies. The obtained results show the strong connection between company performance, expressed by net income, and the quality of the human capital, synthesized by labour productivity.

  17. Posture-Dependent Human 3He Lung Imaging in an Open Access MRI System: Initial Results

    CERN Document Server

    Tsai, L L; Li, C -H; Rosen, M S; Patz, S; Walsworth, R L

    2007-01-01

    The human lung and its functions are extremely sensitive to orientation and posture, and debate continues as to the role of gravity and the surrounding anatomy in determining lung function and heterogeneity of perfusion and ventilation. However, study of these effects is difficult. The conventional high-field magnets used for most hyperpolarized 3He MRI of the human lung, and most other common radiological imaging modalities including PET and CT, restrict subjects to lying horizontally, minimizing most gravitational effects. In this paper, we briefly review the motivation for posture-dependent studies of human lung function, and present initial imaging results of human lungs in the supine and vertical body orientations using inhaled hyperpolarized 3He gas and an open-access MRI instrument. The open geometry of this MRI system features a "walk-in" capability that permits subjects to be imaged in vertical and horizontal positions, and potentially allows for complete rotation of the orientation of the imaging su...

  18. The lawful uses of knowledge from the Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Grad, F.P.

    1994-04-15

    Part I of this study deals with the right to know or not to know personal genetic information, and examines available legal protections of the right of privacy and the adverse effect of the disclosure of genetic information both on employment and insurance interests and on self esteem and protection of personal integrity. The study examines the rationale for the legal protection of privacy as the protection of a public interest. It examines the very limited protections currently available for privacy interests, including genetic privacy interests, and concludes that there is a need for broader, more far-reaching legal protections. The second part of the study is based on the assumption that as major a project as the Human Genome Project, spending billions of dollars on science which is health related, will indeed be applied for preventive and therapeutic public health purposes, as it has been in the past. It also addresses the recurring fear that public health initiatives in the genetic area must evolve a new eugenic agenda, that we must not repeat the miserable discriminatory experiences of the past.

  19. Can free open access resources strengthen knowledge-based emerging public health priorities, policies and programs in Africa? [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Ernest Tambo

    2016-05-01

    Full Text Available Tackling emerging epidemics and infectious diseases burden in Africa requires increasing unrestricted open access and free use or reuse of regional and global policies reforms as well as timely communication capabilities and strategies. Promoting, scaling up data and information sharing between African researchers and international partners are of vital importance in accelerating open access at no cost. Free Open Access (FOA health data and information acceptability, uptake tactics and sustainable mechanisms are urgently needed. These are critical in establishing real time and effective knowledge or evidence-based translation, proven and validated approaches, strategies and tools to strengthen and revamp health systems.  As such, early and timely access to needed emerging public health information is meant to be instrumental and valuable for policy-makers, implementers, care providers, researchers, health-related institutions and stakeholders including populations when guiding health financing, and planning contextual programs.

  20. Access to essential maternal health interventions and human rights violations among vulnerable communities in eastern Burma.

    Directory of Open Access Journals (Sweden)

    Luke C Mullany

    2008-12-01

    Full Text Available BACKGROUND: Health indicators are poor and human rights violations are widespread in eastern Burma. Reproductive and maternal health indicators have not been measured in this setting but are necessary as part of an evaluation of a multi-ethnic pilot project exploring strategies to increase access to essential maternal health interventions. The goal of this study is to estimate coverage of maternal health services prior to this project and associations between exposure to human rights violations and access to such services. METHODS AND FINDINGS: Selected communities in the Shan, Mon, Karen, and Karenni regions of eastern Burma that were accessible to community-based organizations operating from Thailand were surveyed to estimate coverage of reproductive, maternal, and family planning services, and to assess exposure to household-level human rights violations within the pilot-project target population. Two-stage cluster sampling surveys among ever-married women of reproductive age (15-45 y documented access to essential antenatal care interventions, skilled attendance at birth, postnatal care, and family planning services. Mid-upper arm circumference, hemoglobin by color scale, and Plasmodium falciparum parasitemia by rapid diagnostic dipstick were measured. Exposure to human rights violations in the prior 12 mo was recorded. Between September 2006 and January 2007, 2,914 surveys were conducted. Eighty-eight percent of women reported a home delivery for their last pregnancy (within previous 5 y. Skilled attendance at birth (5.1%, any (39.3% or > or = 4 (16.7% antenatal visits, use of an insecticide-treated bed net (21.6%, and receipt of iron supplements (11.8% were low. At the time of the survey, more than 60% of women had hemoglobin level estimates < or = 11.0 g/dl and 7.2% were Pf positive. Unmet need for contraceptives exceeded 60%. Violations of rights were widely reported: 32.1% of Karenni households reported forced labor and 10% of Karen

  1. Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control

    Directory of Open Access Journals (Sweden)

    Taylor MJ

    2014-08-01

    Full Text Available Michael J Taylor, Tara A Garrard, Francis J O'Donahoo, Kirstin E Ross Health and Environment, School of the Environment, Flinders University, Adelaide, SA, Australia Abstract: Strongyloides is a human parasitic nematode that is poorly understood outside a clinical context. This article identifies gaps within the literature, with particular emphasis on gaps that are hindering environmental control of Strongyloides. The prevalence and distribution of Strongyloides is unclear. An estimate of 100–370 million people infected worldwide has been proposed; however, inaccuracy of diagnosis, unreliability of prevalence mapping, and the fact that strongyloidiasis remains a neglected disease suggest that the higher figure of more than 300 million cases is likely to be a more accurate estimate. The complexity of Strongyloides life cycle means that laboratory cultures cannot be maintained outside of a host. This currently limits the range of laboratory-based research, which is vital to controlling Strongyloides through environmental alteration or treatment. Successful clinical treatment with antihelminthic drugs has meant that controlling Strongyloides through environmental control, rather than clinical intervention, has been largely overlooked. These control measures may encompass alteration of the soil environment through physical means, such as desiccation or removal of nutrients, or through chemical or biological agents. Repeated antihelminthic treatment of individuals with recurrent strongyloidiasis has not been observed to result in the selection of resistant strains; however, this has not been explicitly demonstrated, and relying on such assumptions in the long-term may prove to be shortsighted. It is ultimately naive to assume that continued administration of antihelminthics will be without any negative long-term effects. In Australia, strongyloidiasis primarily affects Indigenous communities, including communities from arid central Australia. This

  2. The Construction and Globalization of the Knowledge Base in Inter-human Communication Systems

    CERN Document Server

    Leydesdorff, Loet

    2009-01-01

    The relationship between the "knowledge base" and the "globalization" of communication systems is discussed from the perspective of communication theory. I argue that inter-human communication takes place at two levels. At the first level information is exchanged and provided with meaning and at the second level meaning can reflexively be communicated. Human language can be considered as the evolutionary achievement which enables us to use these two channels of communication simultaneously. Providing meaning from the perspective of hindsight is a recursive operation: a meaning that makes a difference can be considered as knowledge. If the production of knowledge is socially organized, the perspective of hindsight can further be codified. This adds globalization to the historically stabilized patterns of communications. Globalization can be expected to transform the communications in an evolutionary mode. However, the self-organization of a knowledge-based society remains an expectation with the status of a hy...

  3. Generalization of category knowledge and dimensional categorization in humans (Homo sapiens) and nonhuman primates (Macaca mulatta).

    Science.gov (United States)

    Smith, J David; Zakrzewski, Alexandria C; Johnston, Jennifer J R; Roeder, Jessica L; Boomer, Joseph; Ashby, F Gregory; Church, Barbara A

    2015-10-01

    A theoretical framework within neuroscience distinguishes humans' implicit and explicit systems for category learning. We used a perceptual-categorization paradigm to ask whether nonhumans share elements of these systems. Participants learned categories that foster implicit or explicit categorization in humans, because they had a multidimensional, information-integration (II) solution or a unidimensional, rule-based (RB) solution. Then humans and macaques generalized their category knowledge to new, untested regions of the stimulus space. II generalization was impaired, suggesting that II category learning is conditioned and constrained by stimulus generalization to its original, trained stimulus contexts. RB generalization was nearly seamless, suggesting that RB category knowledge in humans and monkeys has properties that grant it some independence from the original, trained stimulus contexts. These findings raise the questions of (a) how closely macaques' dimensional categorization verges on humans' explicit/declarative categorization, and (b) how far macaques' dimensional categorization has advanced beyond that in other vertebrate species.

  4. Linking Human Resource Management and Knowledge Management via Commitment to Safety

    Directory of Open Access Journals (Sweden)

    Kuimet Karin

    2015-11-01

    Full Text Available This paper contributes to the development of the human resource management (HRM, organisational (safety culture and knowledge management literature through developing the linkage and relationship among them. The article suggests that the HRM concepts and frameworks could play an important role in the safety knowledge exchange within the organisation. The research method includes exploratory case studies, interviews and evaluation questionnaires in order to clarify how HRM practices are adopted for safety management systems.

  5. German medical students' interest in and knowledge about human sexuality in 1972 and 2012.

    Science.gov (United States)

    Turner, Daniel; Jopt, Konstantin; Nieder, Timo O; Briken, Peer

    2014-08-01

    During the 1970s, a growing number of medical schools began to recognize the importance of medical education concerning human sexuality. Currently, most medical schools provide at least some instruction in human sexuality. In light of this development, the present study aimed to compare the interest in and knowledge about human sexuality of medical students from two different time periods. The answers to a self-constructed questionnaire of 236 students in 1972 were compared with those of 259 students in 2012. Students were asked whether they were interested in education regarding human sexuality and which specific topics they felt should be included in the medical curriculum. The students' knowledge in the following domains was assessed: sexual development, sexual behavior, sexual physiology and psychology, and sexual medicine. The two cohorts were compared with regard to those specific sexuality-related topics in which the students were most and least interested in. Furthermore, the number of correct responses to the knowledge questions was compared. While in 1972, 99.2% of the students were interested in medical education about human sexuality, in 2012, 80.3% showed an interest. The connection of disorders from different medical disciplines with sexuality was rated as most interesting by both the students from 1972 and 2012. Medical students from 2012 gave 50.3% correct answers to the knowledge questions, whereas students from 1972 correctly answered 46.3% of the questions. Although interest in education concerning human sexuality has decreased, the majority of students view it as an important topic. Nevertheless, medical students still lack knowledge about important aspects of human sexuality (e.g., psychosexual development and relative safety of different contraceptives). Therefore, more time should be dedicated to education concerning human sexuality and its cultural, societal, and health aspects in particular. © 2014 International Society for Sexual Medicine.

  6. Enhancing Access to Knowledge Management Literature — A Proposal for Domain-Based Classification Scheme and Thesaurus

    OpenAIRE

    Denise A. D. Bedford

    2015-01-01

    Knowledge organisation systems (KOS) include a variety of tools and methods for organising information and knowledge 'things'. When we refer to KOS we generally mean classification schemes, thesauri, semantic networks, and authority control systems. Most academic disciplines are supported by professionally developed and maintained KOS. This is not the case for knowledge management. Knowledge management is insufficiently treated in existing KOS. The research is exploratory in its approach to d...

  7. Strategies for transforming human service organizations into learning organizations: knowledge management and the transfer of learning.

    Science.gov (United States)

    Austin, Michael J

    2008-01-01

    This analysis describes the nature of a learning organization, defines the boundaries of evidence-informed practice, identifies the elements of knowledge management, and specifies the elements of the transfer of learning. A set of principles are presented to guide managers in transforming human service organizations into learning organizations along with a set of implementation strategies that can inform participants of the values and benefits of knowledge management. This analysis features concepts and principles adapted and synthesized from research in diverse fields, such as evidence-based health care and the for-profit sector related to learning organizations, knowledge management, and the transfer of learning.

  8. Management of Indigenous Knowledge as a Catalyst towards Improved Information Accessibility to Local Communities: A Literature R

    Directory of Open Access Journals (Sweden)

    Iyoro Abiodun Olaide

    2013-06-01

    Full Text Available This paper reviews the existing literature on how the management of indigenous knowledge could lead to its effective utilization. Indigenous knowledge is different from other types of knowledge. It could be an important tool to ensure the sustainability of societal development of local communities.

  9. Human rights and access to healthcare services for indigenous peoples in Africa.

    Science.gov (United States)

    Durojaye, Ebenezer

    2017-09-20

    In September 2015, the United Nations adopted the sustainable development goals (SDGs) to address among others poverty and inequality within and among countries of the world. In particular, the SDGs aim at ameliorating the position of disadvantaged and vulnerable groups in societies. One of the over-arching goals of the SDGs is to ensure that no one is left behind in the realisation of their access to health care. African governments are obligated under international and regional human rights law to ensure access to healthcare services for everyone, including indigenous populations, on a non-discriminatory basis. This requires the governments to adopt appropriate measures that will remove barriers to healthcare services for disadvantaged and marginalised groups such as indigenous peoples.

  10. Cultivating Humanity or Educating the Human? Two Options for Education in the Knowledge Age

    Science.gov (United States)

    Biesta, Gert

    2014-01-01

    Ever since the idea of the "knowledge society" came into circulation, there have been discussions about what the term empirically "might" mean and normatively "should" mean. In the literature we can find a rather wide spectrum, ranging from a "utilitarian" interpretation of the knowledge society as a…

  11. Free Open Access Medical Education resource knowledge and utilisation amongst Emergency Medicine trainees: A survey in four countries

    Directory of Open Access Journals (Sweden)

    Natalie Thurtle

    2016-03-01

    The Emergency Medicine trainees in both developed and low resource settings studied were aware that Free Open Access Medical Education resources exist, but trainees in lower income settings were generally less aware of specific resources. Lack of internet and device access was not a barrier to use in this group.

  12. University Students' Knowledge and Attitudes Regarding Cervical Cancer, Human Papillomavirus, and Human Papillomavirus Vaccines in Turkey

    Science.gov (United States)

    Koç, Zeliha

    2015-01-01

    Objectives: The current descriptive study aimed to determine university students' knowledge and attitudes regarding cervical cancer, human papillomavirus (HPV), and HPV vaccines in Turkey. Participants: A total of 800 students participated. Methods: This study was carried out between September 1, 2012, and October 30, 2012, in 8 female…

  13. LINKING HUMAN RESOURCES STRATEGY WITH KNOWLEDGE MANAGEMENT STRATEGY TO DRIVE MEASURABLE RESULTS

    Directory of Open Access Journals (Sweden)

    Otilia‐Maria\tBORDEIANU

    2015-06-01

    Full Text Available Today the human resources are seen as a very valuable asset to achieve long-term performance. Today we understand that every employee is required to learn throughout life, so to acquire new knowledge, to process such knowledge and possibly disseminate expertise with other members of the organization. The theory on human resources in various organizations has changed over time; recommendations have become more numerous, but there is no consensus on the subject. In other words, the permanent change which defines the competitive environment of business remains a type of constant when analysing the efficiency of human resources within companies; inter-individual relations (formal and informal and the values to which each employee relates remains crucial for any theoretical construction in this area. Principles and strategies applied by organizations yesterday could prove their inefficiency today; human resource strategies in organizations today should include a separate subcomponent, we believe, i.e. knowledge management (KM strategy. This is because the competitive advantage obtained or maintained by the company depends today, in large proportion, on the type, quality and value of knowledge possessed by the organization. Therefore, organizational strategy and thus the strategy of acquisition, developing and rewarding of human resources (HR should take into account this reality from the global environment. Moreover, in the current knowledge-driven economy, organizations must know how to develop and implement knowledge-based strategies to drive measurable business results. The goal of this paper is to describe a potential relation between the overall company strategy, HR strategy and KM strategy.

  14. Human papillomavirus (HPV) knowledge and prevention practices among Sierra Sur, Oaxaca college students

    OpenAIRE

    Bustamante Ramos, Gisela Mayra; Instituto de Investigación sobre la Salud Pública (IISSP), Universidad de la Sierra Sur, Oaxaca, México; Martínez-Sánchez, Abisai; Instituto de Investigación sobre la Salud Pública (IISSP), Universidad de la Sierra Sur, Oaxaca, México; Tenahua-Quitl, Inés; Facultad de Enfermería, Benemérita Universidad Autónoma de Puebla, México; Jiménez, Concepción; Estudiante de la licenciatura en Enfermería, Instituto de Investigación sobre la Salud Pública (IISSP), Universidad de la Sierra Sur, Oaxaca, México; López Mendoza, Yarely; Estudiante de la licenciatura en Enfermería, Instituto de Investigación sobre la Salud Pública (IISSP), Universidad de la Sierra Sur, Oaxaca, México

    2016-01-01

    Introduction. Human papillomavirus (HPV) causes the world’s most important sexually transmitted infection and is considered the main agent for cervical cancer. Youngsters are most vulnerable as they usually begin sexual relations without protection. Objectives. To describe students’ knowledge of human papillomavirus infection prevention at Sierra Sur, Oaxaca University. Design. Quantitative, descriptive cross-sectional study. Place. Sierra Sur, Oaxaca, Mexico. Participants. University student...

  15. HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.

    Science.gov (United States)

    Zhang, Guang Lan; Riemer, Angelika B; Keskin, Derin B; Chitkushev, Lou; Reinherz, Ellis L; Brusic, Vladimir

    2014-01-01

    High-risk human papillomaviruses (HPVs) are the causes of many cancers, including cervical, anal, vulvar, vaginal, penile and oropharyngeal. To facilitate diagnosis, prognosis and characterization of these cancers, it is necessary to make full use of the immunological data on HPV available through publications, technical reports and databases. These data vary in granularity, quality and complexity. The extraction of knowledge from the vast amount of immunological data using data mining techniques remains a challenging task. To support integration of data and knowledge in virology and vaccinology, we developed a framework called KB-builder to streamline the development and deployment of web-accessible immunological knowledge systems. The framework consists of seven major functional modules, each facilitating a specific aspect of the knowledgebase construction process. Using KB-builder, we constructed the Human Papillomavirus T cell Antigen Database (HPVdb). It contains 2781 curated antigen entries of antigenic proteins derived from 18 genotypes of high-risk HPV and 18 genotypes of low-risk HPV. The HPVdb also catalogs 191 verified T cell epitopes and 45 verified human leukocyte antigen (HLA) ligands. Primary amino acid sequences of HPV antigens were collected and annotated from the UniProtKB. T cell epitopes and HLA ligands were collected from data mining of scientific literature and databases. The data were subject to extensive quality control (redundancy elimination, error detection and vocabulary consolidation). A set of computational tools for an in-depth analysis, such as sequence comparison using BLAST search, multiple alignments of antigens, classification of HPV types based on cancer risk, T cell epitope/HLA ligand visualization, T cell epitope/HLA ligand conservation analysis and sequence variability analysis, has been integrated within the HPVdb. Predicted Class I and Class II HLA binding peptides for 15 common HLA alleles are included in this database as

  16. Health, healthcare access, and use of traditional versus modern medicine in remote Peruvian Amazon communities: a descriptive study of knowledge, attitudes, and practices.

    Science.gov (United States)

    Williamson, Jonathan; Ramirez, Ronald; Wingfield, Tom

    2015-04-01

    There is an urgent need for healthcare research, funding, and infrastructure in the Peruvian Amazon. We performed a descriptive study of health, health knowledge and practice, and healthcare access of 13 remote communities of the Manatí and Amazon Rivers in northeastern Peru. Eighty-five adults attending a medical boat service were interviewed to collect data on socioeconomic position, health, diagnosed illnesses, pain, healthcare access, and traditional versus modern medicine use. In this setting, poverty and gender inequality were prevalent, and healthcare access was limited by long distances to the health post and long waiting times. There was a high burden of reported pain (mainly head and musculoskeletal) and chronic non-communicable diseases, such as hypertension (19%). Nearly all participants felt that they did not completely understand their diagnosed illnesses and wanted to know more. Participants preferred modern over traditional medicine, predominantly because of mistrust or lack of belief in traditional medicine. Our findings provide novel evidence concerning transitional health beliefs, hidden pain, and chronic non-communicable disease prevalence in marginalized communities of the Peruvian Amazon. Healthcare provision was limited by a breach between health education, knowledge, and access. Additional participatory research with similar rural populations is required to inform regional healthcare policy and decision-making.

  17. A Novel Method for Intraoral Access to the Superior Head of the Human Lateral Pterygoid Muscle

    Directory of Open Access Journals (Sweden)

    Aleli Tôrres Oliveira

    2014-01-01

    Full Text Available Background. The uncoordinated activity of the superior and inferior parts of the lateral pterygoid muscle (LPM has been suggested to be one of the causes of temporomandibular joint (TMJ disc displacement. A therapy for this muscle disorder is the injection of botulinum toxin (BTX, of the LPM. However, there is a potential risk of side effects with the injection guide methods currently available. In addition, they do not permit appropriate differentiation between the two bellies of the muscle. Herein, a novel method is presented to provide intraoral access to the superior head of the human LPM with maximal control and minimal hazards. Methods. Computational tomography along with digital imaging software programs and rapid prototyping techniques were used to create a rapid prototyped guide to orient BTX injections in the superior LPM. Results. The method proved to be feasible and reliable. Furthermore, when tested in one volunteer it allowed precise access to the upper head of LPM, without producing side effects. Conclusions. The prototyped guide presented in this paper is a novel tool that provides intraoral access to the superior head of the LPM. Further studies will be necessary to test the efficacy and validate this method in a larger cohort of subjects.

  18. Accessing key steps of human tumor progression in vivo by using an avian embryo model

    Science.gov (United States)

    Hagedorn, Martin; Javerzat, Sophie; Gilges, Delphine; Meyre, Aurélie; de Lafarge, Benjamin; Eichmann, Anne; Bikfalvi, Andreas

    2005-02-01

    Experimental in vivo tumor models are essential for comprehending the dynamic process of human cancer progression, identifying therapeutic targets, and evaluating antitumor drugs. However, current rodent models are limited by high costs, long experimental duration, variability, restricted accessibility to the tumor, and major ethical concerns. To avoid these shortcomings, we investigated whether tumor growth on the chick chorio-allantoic membrane after human glioblastoma cell grafting would replicate characteristics of the human disease. Avascular tumors consistently formed within 2 days, then progressed through vascular endothelial growth factor receptor 2-dependent angiogenesis, associated with hemorrhage, necrosis, and peritumoral edema. Blocking of vascular endothelial growth factor receptor 2 and platelet-derived growth factor receptor signaling pathways by using small-molecule receptor tyrosine kinase inhibitors abrogated tumor development. Gene regulation during the angiogenic switch was analyzed by oligonucleotide microarrays. Defined sample selection for gene profiling permitted identification of regulated genes whose functions are associated mainly with tumor vascularization and growth. Furthermore, expression of known tumor progression genes identified in the screen (IL-6 and cysteine-rich angiogenic inducer 61) as well as potential regulators (lumican and F-box-only 6) follow similar patterns in patient glioma. The model reliably simulates key features of human glioma growth in a few days and thus could considerably increase the speed and efficacy of research on human tumor progression and preclinical drug screening. angiogenesis | animal model alternatives | glioblastoma

  19. Dichotomous Identification Keys: A Ladder to Higher Order Knowledge about the Human Body

    Science.gov (United States)

    Sorgo, Andrej

    2006-01-01

    We tried to enrich teaching human anatomy in high school biology lessons. Students construct dichotomous identification keys to the cells, tissues, organs, or body parts. By doing this, students have achieved higher-order cognitive levels of knowledge because construction of such keys is based on analysis, synthesis, and evaluation. Students found…

  20. Information about Human Sexuality: Sources, Satisfaction, and Perceived Knowledge among College Students

    Science.gov (United States)

    Rutledge, Scott Edward; Siebert, Darcy Clay; Chonody, Jill; Killian, Michael

    2011-01-01

    This study explored how 333 undergraduate and graduate students attending a large university in the southeastern USA learned about sex, their satisfaction with how they learned about sex, and their self-perceived knowledge before and after taking a human sexuality course. An anonymous, voluntary survey was administered to students in the first and…

  1. Digital Conservation and Access: Saving Humanity's History in the Petabyte Age

    Directory of Open Access Journals (Sweden)

    Michael Ashley

    2010-04-01

    Full Text Available We are at a unique point in history, the cusp of a Digital Dark Age, where cultural heritage professionals must work to care for the physical past while assuring that there will be a digital Rosetta Stone for future generations. This contribution describes the state-of-the-field in digital preservation and access, and is a call to action for individuals and institutions alike to work beyond our comfort zones and competitive boundaries in order to help define a sustainable digital future. Defined as an “hourglass of participation”, I describe a method where knowledge producers, curators and consumers interact and actively work to make content born-archival and long-term viable, semantically managed and ready for reuse and public dissemination

  2. Human papillomavirus and anorectal carcinoma knowledge in men who have sex with men.

    Science.gov (United States)

    Blackwell, Christopher W; Eden, Candace

    2011-01-01

    Human papillomavirus (HPV) infection is a precursor to the development of anorectal carcinoma. Studies have indicated that men who have sex with men (MSM) have significantly higher rates of HPV and HIV than their heterosexual counterparts and are at greater risk for anorectal carcinoma. This article presents findings from a descriptive study to assess knowledge of HPV, anorectal carcinoma, and anorectal screening in a sample of MSM in Orlando, FL. The 89 participants demonstrated knowledge deficits. The average score on knowledge items was only 38% correct. Of the 49 participants who had heard of anal Papanicolau (Pap) smears, only 5 (10.2%) discussed screening with a physician, while 8 (16.3%) had discussed it with a nurse, and 16 (32.7%) with another health care professional. Findings support the need for community outreach efforts to promote knowledge and the need for discussion with providers regarding HPV and anorectal carcinoma in this vulnerable population.

  3. An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development.

    Science.gov (United States)

    Koh, Pang Wei; Sinha, Rahul; Barkal, Amira A; Morganti, Rachel M; Chen, Angela; Weissman, Irving L; Ang, Lay Teng; Kundaje, Anshul; Loh, Kyle M

    2016-12-20

    Mesoderm is the developmental precursor to myriad human tissues including bone, heart, and skeletal muscle. Unravelling the molecular events through which these lineages become diversified from one another is integral to developmental biology and understanding changes in cellular fate. To this end, we developed an in vitro system to differentiate human pluripotent stem cells through primitive streak intermediates into paraxial mesoderm and its derivatives (somites, sclerotome, dermomyotome) and separately, into lateral mesoderm and its derivatives (cardiac mesoderm). Whole-population and single-cell analyses of these purified populations of human mesoderm lineages through RNA-seq, ATAC-seq, and high-throughput surface marker screens illustrated how transcriptional changes co-occur with changes in open chromatin and surface marker landscapes throughout human mesoderm development. This molecular atlas will facilitate study of human mesoderm development (which cannot be interrogated in vivo due to restrictions on human embryo studies) and provides a broad resource for the study of gene regulation in development at the single-cell level, knowledge that might one day be exploited for regenerative medicine.

  4. A Human Rights Approach for Access to Clean Drinking Water: A Case Study.

    Science.gov (United States)

    Kanaaneh; McKay; Sims

    1995-01-01

    In northern and central Israel are some 70 villages that are not recognized by the state of Israel. At least half of these villages are not connected to the national drinking water networks and lack sufficient quality and quantity of water. Outbreaks of diseases associated with contaminated water supply have occurred, as well as substantial environmental distress. An outbreak of hepatitis A led to the cooperation of a public health physician, a nurse, an environmental engineer, and a human rights lawyer in successfully taking a case to the International Water Tribunal to get access to safe drinking water for these communities. This case study provides a model for cooperation between proponents and practitioners of health and human rights.

  5. Accessing word meaning: Semantic word knowledge and reading comprehension in Dutch monolingual and bilingual fifth-graders

    NARCIS (Netherlands)

    Cremer, M.

    2013-01-01

    Word knowledge is one of the key elements in reading comprehension and by extension in school success. At the same time, it is not quite clear which components of lexical knowledge play a role in reading. Is it enough to recognize the words we read? Do we need an in-depth understanding of their mean

  6. Innovations in Measuring Peer Conflict Resolution Knowledge in Children with LI: Exploring the Accessibility of a Visual Analogue Rating Scale

    Science.gov (United States)

    Campbell, Wenonah N.; Skarakis-Doyle, Elizabeth

    2011-01-01

    This preliminary study explored peer conflict resolution knowledge in children with and without language impairment (LI). Specifically, it evaluated the utility of a visual analogue scale (VAS) for measuring nuances in such knowledge. Children aged 9-12 years, 26 with typically developing language (TLD) and 6 with LI, completed a training protocol…

  7. The Role of Human Resource Management Practice Mediated by Knowledge Management (Study on companies from ICT sector, Croatia

    Directory of Open Access Journals (Sweden)

    Marina Klacmer Calopa

    2015-05-01

    Full Text Available This paper integrates theories and findings of the role of human resources management (HRM in the process of knowledge management (KM in the information and communication technologies (ICT sector in Croatia.In order to succeed, companies must prevent the loss of knowledge. Therefore, they must recognize the importance of human resources as the main factor of business. Only knowledge management enables knowledge sharing.Furthermore, applications of information technology (IT in the field of HRM can prevent the loss of knowledge and arise the transfer of knowledge among employees.For the purpose of this paper, a survey regarding human resource and knowledge management in IT companies is conducted in order to analyze the structure of HR and the importance of knowledge sharing in an organization.

  8. Survey of knowledge and perception on the access to evidence-based practice and clinical practice change among maternal and infant health practitioners in South East Asia

    Directory of Open Access Journals (Sweden)

    Crowther Caroline A

    2008-08-01

    Full Text Available Abstract Background Evidence-based practice (EBP can provide appropriate care for women and their babies; however implementation of EBP requires health professionals to have access to knowledge, the ability to interpret health care information and then strategies to apply care. The aim of this survey was to assess current knowledge of evidence-based practice, information seeking practices, perceptions and potential enablers and barriers to clinical practice change among maternal and infant health practitioners in South East Asia. Methods Questionnaires about IT access for health information and evidence-based practice were administered during August to December 2005 to health care professionals working at the nine hospitals participating in the South East Asia Optimising Reproductive and Child Health in Developing countries (SEA-ORCHID project in Indonesia, Malaysia, Thailand and The Philippines. Results The survey was completed by 660 staff from six health professional groups. Overall, easy IT access for health care information was available to 46% of participants. However, over a fifth reported no IT access was available and over half of nurses and midwives never used IT health information. Evidence-based practice had been heard of by 58% but the majority did not understand the concept. The most frequent sites accessed were Google and PubMed. The Cochrane Library had been heard of by 47% of whom 51% had access although the majority did not use it or used it less than monthly. Only 27% had heard of the WHO Reproductive Health Library and 35% had been involved in a clinical practice change and were able to identify enablers and barriers to change. Only a third of participants had been actively involved in practice change with wide variation between the countries. Willingness to participate in professional development workshops on evidence-based practice was high. Conclusion This survey has identified the need to improve IT access to health care

  9. Innovations in workplace accessibility and accommodation for persons with hearing loss: using social networking and community of practice theory to promote knowledge exchange and change.

    Science.gov (United States)

    Shaw, Lynn; Jennings, Mary Beth; Poost-Foroosh, Laya; Hodgins, Heather; Kuchar, Ashley

    2013-01-01

    Despite widespread availability of assistive technology and the role of occupational therapists and audiologists in workplace health, little is known about how these groups influence the health of workers with hearing loss. Based on a previously conducted study, this paper explores the need for networking and community of practice theory to promote knowledge sharing and use between occupational therapists, audiologists, educators, regulators, workers, and employers. Five occupational therapists and five audiologists participated in in-depth interviews. Grounded theory was used to investigate the processes that hinder or support these professionals in addressing the accommodation needs of and workplace accessibility for workers with hearing loss. Constraints to addressing the needs of workers with hearing loss included: lack of knowledge about professional practice processes, lack of networking, lack of knowledge on current research, and lack of knowledge on the realm of expertise of audiologists by occupational therapists and of occupational therapists by audiologists. Innovations in workplace practice in hearing loss require engagement of occupational therapists, audiologists, and employers in knowledge transfer, networking, and learning. This column introduces two theories that may guide the use and development of evidence, knowledge, and expertise toward innovations in hearing work practice.

  10. KNOWLEDGE MANAGEMENT UNTUK CUSTOMER SERVICE

    Directory of Open Access Journals (Sweden)

    Lianna Sugandi

    2010-10-01

    Full Text Available Knowledge is a success key in every field aspects. Along with the development in the world nowadays, where globalization is a challenge in every Indonesian human resource to face global competition. In this case, education has important part as media in developing qualified human resources and also as the place where they can be educated in their field. In the development of information technology, it came new systems in several fields including what educational field known as e-learning. Knowledge management (KM is one implementation of e-learning. There is a concept that gathers all knowledge aspects in easily accessed file or document, and also in hardly accessed as knowledge and experience.Keywords: knowledge management, human resource, education

  11. The influence of lexical-access ability and vocabulary knowledge on measures of speech recognition in noise.

    Science.gov (United States)

    Kaandorp, Marre W; De Groot, Annette M B; Festen, Joost M; Smits, Cas; Goverts, S Theo

    2016-01-01

    The main objective was to investigate the effect of linguistic abilities (lexical-access ability and vocabulary size) on different measures of speech-in-noise recognition in normal-hearing listeners with various levels of language proficiency. Speech reception thresholds (SRTs) were measured for sentences in steady-state (SRTstat) and fluctuating noise (SRTfluc), and for digit-triplets in steady-state noise (DIN). Lexical-access ability was measured with a lexical-decision test and a word-naming test. Vocabulary size was also measured. For the SRT, keyword scoring and sentence scoring were compared. To introduce variation in linguistic abilities, three groups of 24 young normal-hearing listeners were included: higher-educated native, lower-educated native, and higher-educated non-native listeners. Lexical-access ability was most accurately measured with combined results of lexical decision and word naming. Lexical-access ability explained 60% of the variance in SRT. The effect of linguistic abilities on SRTs was up to 5.6 dB for SRTstat and 8 dB for SRTfluc. Using keyword scoring reduced this effect by approximately 1.5 dB. For DIN the effect of linguistic ability was less than 1 dB. Lexical-access ability is an important predictor of SRTs in normal-hearing listeners. These results are important to consider in the interpretation of speech-in-noise scores of hearing-impaired listeners.

  12. The Visible Heart® project and free-access website 'Atlas of Human Cardiac Anatomy'.

    Science.gov (United States)

    Iaizzo, Paul A

    2016-12-01

    Pre- and post-evaluations of implantable cardiac devices require innovative and critical testing in all phases of the design process. The Visible Heart(®) Project was successfully launched in 1997 and 3 years later the Atlas of Human Cardiac Anatomy website was online. The Visible Heart(®) methodologies and Atlas website can be used to better understand human cardiac anatomy, disease states and/or to improve cardiac device design throughout the development process. To date, Visible(®) Heart methodologies have been used to reanimate 75 human hearts, all considered non-viable for transplantation. The Atlas is a unique free-access website featuring novel images of functional and fixed human cardiac anatomies from >400 human heart specimens. Furthermore, this website includes education tutorials on anatomy, physiology, congenital heart disease and various imaging modalities. For instance, the Device Tutorial provides examples of commonly deployed devices that were present at the time of in vitro reanimation or were subsequently delivered, including: leads, catheters, valves, annuloplasty rings, leadless pacemakers and stents. Another section of the website displays 3D models of vasculature, blood volumes, and/or tissue volumes reconstructed from computed tomography (CT) and magnetic resonance images (MRI) of various heart specimens. A new section allows the user to interact with various heart models. Visible Heart(®) methodologies have enabled our laboratory to reanimate 75 human hearts and visualize functional cardiac anatomies and device/tissue interfaces. The website freely shares all images, video clips and CT/MRI DICOM files in honour of the generous gifts received from donors and their families. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For Permissions, please email: journals.permissions@oup.com.

  13. Omissions in managing knowledge in innovation processes or how to handle knowledge, humans and tasks : A semio-cognitive approach

    NARCIS (Netherlands)

    Cijsouw, R. S.; Jorna, R. J.; Rakhorst, G.; Verkerke, G. J.; Charrel, PJ; Galarreta, D

    2007-01-01

    In organizations, innovation is a long-lasting process that is difficult to manage. Innovation is characterized by the use of new (combinations of) knowledge. Innovation, as knowledge creation, is also an activity of individuals. However, neither the individual nor knowledge is studied as appropriat

  14. United States Human Access to Space, Exploration of the Moon and Preparation for Mars Exploration

    Science.gov (United States)

    Rhatigan, Jennifer L.

    2009-01-01

    In the past, men like Leonardo da Vinci and Jules Verne imagined the future and envisioned fantastic inventions such as winged flying machines, submarines, and parachutes, and posited human adventures like transoceanic flight and journeys to the Moon. Today, many of their ideas are reality and form the basis for our modern world. While individual visionaries like da Vinci and Verne are remembered for the accuracy of their predictions, today entire nations are involved in the process of envisioning and defining the future development of mankind, both on and beyond the Earth itself. Recently, Russian, European, and Chinese teams have all announced plans for developing their own next generation human space vehicles. The Chinese have announced their intention to conduct human lunar exploration, and have flown three crewed space missions since 2003, including a flight with three crew members to test their extravehicular (spacewalking) capabilities in September 2008. Very soon, the prestige, economic development, scientific discovery, and strategic security advantage historically associated with leadership in space exploration and exploitation may no longer be the undisputed province of the United States. Much like the sponsors of the seafaring explorers of da Vinci's age, we are motivated by the opportunity to obtain new knowledge and new resources for the growth and development of our own civilization. NASA's new Constellation Program, established in 2005, is tasked with maintaining the United States leadership in space, exploring the Moon, creating a sustained human lunar presence, and eventually extending human operations to Mars and beyond. Through 2008, the Constellation Program developed a full set of detailed program requirements and is now completing the preliminary design phase for the new Orion Crew Exploration Vehicle (CEV), the Ares I Crew Launch Vehicle, and the associated infrastructure necessary for humans to explore the Moon. Component testing is well

  15. Review of Cold war social science: Knowledge production, liberal democracy, and human nature, and Working knowledge: Making the human sciences from Parsons to Kuhn.

    Science.gov (United States)

    Erickson, Paul

    2013-11-01

    Reviews the books, Cold War Social Science: Knowledge Production, Liberal Democracy, and Human Nature by Mark Solovey and Hamilton Cravens (2012) and Working Knowledge: Making the Human Sciences From Parsons to Kuhn by Joel Isaac (see record 2012-13212-000). Taken together, these two important books make intriguing statements about the way to write the histories of fields like psychology, sociology, anthropology, and economics in the Anglo American world during the 20th century. To date, histories of these fields have drawn on a number of fairly well-established punctuation marks to assist in periodization: the shift from interwar institutionalism in economics to postwar neoclassicism, with its physics-like emphasis on mathematical theory-building; the transition from the regnant prewar behaviorism through a postwar "cognitive revolution" in American psychology; and the move in fields like sociology and anthropology away from positivism and the pursuit of what has sometimes been called "grand theory" in the early postwar era toward a period defined by intellectual and political fragmentation, the reemergence of interpretive approaches and a reaction to the scientistic pretensions of the earlier period. These books, by contrast, provide perspectives orthogonal to such existing narrative frameworks by adopting cross-cutting lenses like the "Cold War" and the working practices of researchers in the social and behavioral sciences. As a result, they do much to indicate the value of casting a historiographical net beyond individual disciplines, or even beyond the "social sciences" or the "human sciences" sensu stricto, in the search for deeper patterns of historical development in these fields. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  16. LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs

    KAUST Repository

    Ma, L.

    2014-11-15

    Long non-coding RNAs (lncRNAs) perform a diversity of functions in numerous important biological processes and are implicated in many human diseases. In this report we present lncRNAWiki (http://lncrna.big.ac.cn), a wiki-based platform that is open-content and publicly editable and aimed at community-based curation and collection of information on human lncRNAs. Current related databases are dependent primarily on curation by experts, making it laborious to annotate the exponentially accumulated information on lncRNAs, which inevitably requires collective efforts in community-based curation of lncRNAs. Unlike existing databases, lncRNAWiki features comprehensive integration of information on human lncRNAs obtained from multiple different resources and allows not only existing lncRNAs to be edited, updated and curated by different users but also the addition of newly identified lncRNAs by any user. It harnesses community collective knowledge in collecting, editing and annotating human lncRNAs and rewards community-curated efforts by providing explicit authorship based on quantified contributions. LncRNAWiki relies on the underling knowledge of scientific community for collective and collaborative curation of human lncRNAs and thus has the potential to serve as an up-to-date and comprehensive knowledgebase for human lncRNAs.

  17. Human papillomavirus knowledge and vaccine acceptability among adolescents in a Greek region.

    Science.gov (United States)

    Anagnostou, P A; Aletras, V H; Niakas, D A

    2017-09-08

    The aim of this research was twofold: (1) develop an instrument to assess knowledge regarding human papillomavirus (HPV) and its vaccine and utilize this instrument to measure knowledge levels of Greek adolescents in Lyceum schools of Western Thessaloniki; and (2) examine the associations of the resultant knowledge measure scores with sociodemographic characteristics. Cross-sectional survey with complex sampling design. A total of 268 students of three Lyceum schools in Western Thessaloniki responded anonymously to a questionnaire during February-March 2013. The instrument was developed by literature review. Answers of respondents to individual questions were initially presented in terms of absolute and relative frequencies. Knowledge items were presented by gender along with appropriate chi-squared tests. Next, the development and validation of a knowledge score was pursued with Rasch analysis. Raw scores of dichotomous true/false items were converted to interval-level adjusted student scores, and the reliability and validity of the model were assessed. Finally, the effect of sociodemographic variables on the knowledge measure was explored by multivariate linear regression. Analysis of individual items documented low knowledge for both female and male students along with a limited role of doctors as information agents and little associated encouragement toward vaccination. Vaccine uptake was low with many young girls being largely unwilling to vaccinate in the future primarily due to the fear of side-effects and lack of information. Person location parameters (knowledge scores) were derived from a Rasch model with satisfactory reliability and validity. The resultant validated measure confirmed the low knowledge levels of Greek students. Nationality and birthplace seemed to affect knowledge level. Further improvement and validation of the knowledge measure used in this study can assist nationwide surveys in order to examine student knowledge regarding HPV and its

  18. Access to a syllabus of human hemoglobin variants (1996) via the World Wide Web.

    Science.gov (United States)

    Hardison, R C; Chui, D H; Riemer, C R; Miller, W; Carver, M F; Molchanova, T P; Efremov, G D; Huisman, T H

    1998-03-01

    Information on mutations in human hemoglobin is important in many efforts, including understanding the pathophysiology of hemoglobin diseases, developing therapies, elucidating the dynamics of sequence alterations inhuman populations, and dissecting the details of protein structure/function relationships. Currently, information is available on a large number of mutations and variants, but is distributed among thousands of papers. In an effort to organize this voluminous data set, two Syllabi have been prepared compiling succinct information on human hemoglobin abnormalities. In both of these, each entry provides amino acid and/or DNA sequence alterations, hematological and clinical data, methodology used for characterization, ethnic distribution, and functional properties and stability of the hemoglobin, together with appropriate literature references. A Syllabus of Human Hemoglobin Variants (1996) describes 693 abnormal hemoglobins resulting from alterations in the alpha-, beta-, gamma-, and delta-globin chains, including special abnormalities such as double mutations, hybrid chains, elongated chains, deletions, and insertions. We have converted this resource to an electronic form that is accessible via the World Wide Web at the Globin Gene Server (http://globin.cse.psu.edu). Hyperlinks are provided from each entry in the tables of variants to the corresponding full description. In addition, a simple query interface allows the user to find all entries containing a designated word or phrase. We are in the process of converting A Syllabus of Thalassemia Mutations (1997) to a similar electronic format.

  19. Testing the importance of family solidarity, community structure, information access, and social capital in predicting nutrition health knowledge and food choices in the Philippines.

    Science.gov (United States)

    Moxley, Robert L; Jicha, Karl A; Thompson, Gretchen H

    2011-01-01

    This study investigates the influence of family solidarity, community structure, information access, social capital, and socioeconomic status on the extent of nutrition and health knowledge (NHK) among primary household meal planners. In turn, we pose the question: does this knowledge influence dietary decision making? Data are taken from a survey determining socioeconomic impacts of vitamin A fortified peanut butter on Philippine households. Questions on the relationships of nutrition to health were selected to construct a knowledge index on which household respondents could be ranked. We then tested hypotheses regarding what types of individual, family-level, and community structural characteristics would predict performance on this index. The results indicate that the strongest predictors of NHK come from sociological theory related to family solidarity and community centrality, in addition to information accessibility and household income. Our findings also indicate that NHK influences dietary choices with regard to the purchase of a vitamin fortified staple food product, which is essential when addressing nutritional deficiency problems in developing countries.

  20. Achieving human and machine accessibility of cited data in scholarly publications

    Science.gov (United States)

    Starr, Joan; Castro, Eleni; Crosas, Mercè; Dumontier, Michel; Downs, Robert R.; Duerr, Ruth; Haak, Laurel L.; Haendel, Melissa; Herman, Ivan; Hodson, Simon; Hourclé, Joe; Kratz, John Ernest; Lin, Jennifer; Nielsen, Lars Holm; Nurnberger, Amy; Proell, Stefan; Rauber, Andreas; Sacchi, Simone; Smith, Arthur; Taylor, Mike; Clark, Tim

    2015-01-01

    Reproducibility and reusability of research results is an important concern in scientific communication and science policy. A foundational element of reproducibility and reusability is the open and persistently available presentation of research data. However, many common approaches for primary data publication in use today do not achieve sufficient long-term robustness, openness, accessibility or uniformity. Nor do they permit comprehensive exploitation by modern Web technologies. This has led to several authoritative studies recommending uniform direct citation of data archived in persistent repositories. Data are to be considered as first-class scholarly objects, and treated similarly in many ways to cited and archived scientific and scholarly literature. Here we briefly review the most current and widely agreed set of principle-based recommendations for scholarly data citation, the Joint Declaration of Data Citation Principles (JDDCP). We then present a framework for operationalizing the JDDCP; and a set of initial recommendations on identifier schemes, identifier resolution behavior, required metadata elements, and best practices for realizing programmatic machine actionability of cited data. The main target audience for the common implementation guidelines in this article consists of publishers, scholarly organizations, and persistent data repositories, including technical staff members in these organizations. But ordinary researchers can also benefit from these recommendations. The guidance provided here is intended to help achieve widespread, uniform human and machine accessibility of deposited data, in support of significantly improved verification, validation, reproducibility and re-use of scholarly/scientific data. PMID:26167542

  1. Achieving human and machine accessibility of cited data in scholarly publications

    Directory of Open Access Journals (Sweden)

    Joan Starr

    2015-05-01

    Full Text Available Reproducibility and reusability of research results is an important concern in scientific communication and science policy. A foundational element of reproducibility and reusability is the open and persistently available presentation of research data. However, many common approaches for primary data publication in use today do not achieve sufficient long-term robustness, openness, accessibility or uniformity. Nor do they permit comprehensive exploitation by modern Web technologies. This has led to several authoritative studies recommending uniform direct citation of data archived in persistent repositories. Data are to be considered as first-class scholarly objects, and treated similarly in many ways to cited and archived scientific and scholarly literature. Here we briefly review the most current and widely agreed set of principle-based recommendations for scholarly data citation, the Joint Declaration of Data Citation Principles (JDDCP. We then present a framework for operationalizing the JDDCP; and a set of initial recommendations on identifier schemes, identifier resolution behavior, required metadata elements, and best practices for realizing programmatic machine actionability of cited data. The main target audience for the common implementation guidelines in this article consists of publishers, scholarly organizations, and persistent data repositories, including technical staff members in these organizations. But ordinary researchers can also benefit from these recommendations. The guidance provided here is intended to help achieve widespread, uniform human and machine accessibility of deposited data, in support of significantly improved verification, validation, reproducibility and re-use of scholarly/scientific data.

  2. Achieving human and machine accessibility of cited data in scholarly publications.

    Science.gov (United States)

    Starr, Joan; Castro, Eleni; Crosas, Mercè; Dumontier, Michel; Downs, Robert R; Duerr, Ruth; Haak, Laurel L; Haendel, Melissa; Herman, Ivan; Hodson, Simon; Hourclé, Joe; Kratz, John Ernest; Lin, Jennifer; Nielsen, Lars Holm; Nurnberger, Amy; Proell, Stefan; Rauber, Andreas; Sacchi, Simone; Smith, Arthur; Taylor, Mike; Clark, Tim

    Reproducibility and reusability of research results is an important concern in scientific communication and science policy. A foundational element of reproducibility and reusability is the open and persistently available presentation of research data. However, many common approaches for primary data publication in use today do not achieve sufficient long-term robustness, openness, accessibility or uniformity. Nor do they permit comprehensive exploitation by modern Web technologies. This has led to several authoritative studies recommending uniform direct citation of data archived in persistent repositories. Data are to be considered as first-class scholarly objects, and treated similarly in many ways to cited and archived scientific and scholarly literature. Here we briefly review the most current and widely agreed set of principle-based recommendations for scholarly data citation, the Joint Declaration of Data Citation Principles (JDDCP). We then present a framework for operationalizing the JDDCP; and a set of initial recommendations on identifier schemes, identifier resolution behavior, required metadata elements, and best practices for realizing programmatic machine actionability of cited data. The main target audience for the common implementation guidelines in this article consists of publishers, scholarly organizations, and persistent data repositories, including technical staff members in these organizations. But ordinary researchers can also benefit from these recommendations. The guidance provided here is intended to help achieve widespread, uniform human and machine accessibility of deposited data, in support of significantly improved verification, validation, reproducibility and re-use of scholarly/scientific data.

  3. Human nicotine conditioning requires explicit contingency knowledge: is addictive behaviour cognitively mediated?

    Science.gov (United States)

    Hogarth, Lee; Duka, Theodora

    2006-03-01

    Two seemingly contrary theories describe the learning mechanisms that mediate human addictive behaviour. According to the classical incentive theories of addiction, addictive behaviour is motivated by a Pavlovian conditioned appetitive emotional response elicited by drug-paired stimuli. Expectancy theory, on the other hand, argues that addictive behaviour is mediated by an expectancy of the drug imparted by cognitive knowledge of the Pavlovian (predictive) contingency between stimuli (S+) and the drug and of the instrumental (causal) contingency between instrumental behaviour and the drug. The present paper reviewed human-nicotine-conditioning studies to assess the role of appetitive emotional conditioning and explicit contingency knowledge in mediating addictive behaviour. The studies reviewed here provided evidence for both the emotional conditioning and the expectancy accounts. The first source of evidence is that nicotine-paired S+ elicit an appetitive emotional conditioned response (CR), albeit only in participants who expect nicotine. Furthermore, the magnitude of this emotional state is modulated by nicotine deprivation/satiation. However, the causal status of the emotional response in driving other forms of conditioned behaviour remains undemonstrated. The second source of evidence is that other nicotine CRs, including physiological responses, self-administration, attentional bias and subjective craving, are also dependent on participants possessing explicit knowledge of the Pavlovian contingencies arranged in the experiment. In addition, several of the nicotine CRs can be brought about or modified by instructed contingency knowledge, demonstrating the causal status of this knowledge. Collectively, these data suggest that human nicotine conditioned effects are mediated by an explicit expectancy of the drug coupled with an appetitive emotional response that reflects the positive biological value of the drug. The implication of this conclusion is that

  4. Aviation or space policy: New challenges for the insurance sector to private human access to space

    Science.gov (United States)

    van Oijhuizen Galhego Rosa, Ana Cristina

    2013-12-01

    The phenomenon of private human access to space has introduced a new set of problems in the insurance sector. Orbital and suborbital space transportation will surely be unique commercial services for this new market. Discussions are under way regarding space insurance, in order to establish whether this new market ought to be regulated by aviation or space law. Alongside new definitions, infrastructures, legal frameworks and liability insurances, the insurance sector has also been introducing a new approach. In this paper, I aim to analyse some of the possibilities of new premiums, capacities, and policies (under aviation or space insurance rules), as well as the new insurance products related to vehicles, passengers and third party liability. This paper claims that a change toward new insurance regimes is crucial, due to the current stage in development of space tourism and the urgency to adapt insurance rules to support future development in this area.

  5. IMPORTANCE OF THE HUMAN FACTOR IN THE KNOWLEDGE-BASED SOCIETY

    Directory of Open Access Journals (Sweden)

    Angela BRETCU

    2016-02-01

    Full Text Available The paper approaches the paradigmatic changes of the current economic situation, in the context of post-modernism and its challenges, which reconsiders human society according to new criteria. One of the characteristics of post-modernism is the development of information and communication techniques, which allowed the occurrence of the „knowledge-based society” whose consequence is the effervescence of fast barrier-free knowledge, absolute freedom of debates, equality of opportunities before the virtual space, but also the relativisation of information, the increases of the danger of manipulation, misleading, or even falsification of the truth. New challenges occur thus in social life, and especially in the economic one, where the human factor becomes increasingly important for the evolution of society. In this context, education seems to play the decisive part, but an education focused on real values, where the truth and the ethics prevail before efficiency and performance.  

  6. Evaluating Effect of Knowledge Management Strategy on Human Resource Management Performance Using BSC Approach

    Directory of Open Access Journals (Sweden)

    Hossein Mansoori

    2012-02-01

    Full Text Available This research provided a model for evaluating the effect of knowledge management strategy on human resource management performance in higher education institutes and academic libraries. This research was a descriptive survey. According to the research literature and expert opinions, in human resource level, 38 indicators were produced for evaluating KM, then these indicators were classified in 10 total factors in terms of balanced scorecard approach. The results of evaluating knowledge management in Yazd academic libraries showed that, this strategy on customer perspectives, internal processes, learning and growth perspective had a good performance. But in terms of financial and Labor productivity indicators and training programs it did not have a good outcome for Yazd academic libraries.

  7. Designing a knowledge management system for distributed activities: a human centered approach.

    Science.gov (United States)

    Rinkus, Susan; Johnson-Throop, Kathy A; Zhang, Jiajie

    2003-01-01

    In this study we use the principles of distributed cognition and the methodology of human-centered distributed information design to analyze a complex distributed human-computer system, identify its problems, and generate design requirements and implementation specifications of a replacement prototype for effective organizational memory and knowledge management. We argue that a distributed human-computer information system has unique properties, structures and processes that are best described in the language of distributed cognition. Distributed cognition provides researchers a richer theoretical understanding of human-computer interactions and enables re-searchers to capture the phenomenon that emerges in social interactions as well as the interactions between people and structures in their environment.

  8. The arhitecture of the human resources in management based on knowledge and the impact on reduncing unemployment

    Directory of Open Access Journals (Sweden)

    Amalia Venera Todoruţ

    2011-03-01

    Full Text Available In this working paper I proposed to address/aproach issues of relationship and interdependence of human resources and management based on knowledges. I presented during the paper the new type of human resource management and new challenges which are noted in the current economic conjuncture and their influences on human resource management. We have also shown which is the new type of organizational culture and its impact on management based on knowledge. I focused also on the modalities how influence the management of human resources the management based on knowledge materialized in: the organization employee involvement, strong motivation and retention of employees in the firm based on knowledge, connection of management based on knowledges and the human resource management on the firm strategy, development of employees capacity and the intellectual capital, the creation and maintenance of learning practices widely used in business.

  9. Fostering students' knowledge and argumentation skills through dilemmas in human genetics

    Science.gov (United States)

    Zohar, Anat; Nemet, Flora

    2002-01-01

    This study examined the outcomes of a unit that integrates explicit teaching of general reasoning patterns into the teaching of a specific science content. Specifically, this article examined the teaching of argumentation skills in the context of dilemmas in human genetics. Before instruction only a minority (16.2%) of the students referred to correct, specific biological knowledge in constructing arguments in the context of dilemmas in genetics. Approximately 90% of the students were successful in formulating simple arguments. An assessment that took place following instruction supported the conclusion that integrating explicit teaching of argumentation into the teaching of dilemmas in human genetics enhances performance in both biological knowledge and argumentation. An increase was found in the frequency of students who referred to correct, specific biological knowledge in constructing arguments. Students in the experimental group scored significantly higher than students in the comparison group in a test of genetics knowledge. An increase was also found in the quality of students' argumentation. Students were able to transfer the reasoning abilities taught in the context of genetics to the context of dilemmas taken from everyday life. The effects of metacognitive thinking and of changing students' thinking dispositions by modifying what is considered valuable in the class culture are discussed.

  10. Knowledge about Human Papilloma Virus (HPV and HPV Vaccine at Reproductive Age in Primary Care

    Directory of Open Access Journals (Sweden)

    Ozde Onder

    2015-09-01

    Full Text Available Purpose: The aim of this study was to identify the knowledge and awareness about human papilloma virus (HPV and human papilloma virus (HPV vaccine of women in reproductive age. Material and Methods: The study covered 294 women aged between 15 and 49. A questionnaire was prepared by the researchers based on the literature review. Results: The mean age of the participants was 30.5+/-8.9 years. Only 24.5% had heard about HPV infection and 28.2% had heard HPV vaccine. Of the participants, 188 (63.9% got zero point from the knowledge questions. Conclusion: This study indicates that the women who apply primary care units have low knowledge levels; it is apperent that personal and social education is needed. Paying importance to patient education on HPV and cervical cancer in primary care health politics will increase knowledge and awareness for HPV infection and HPV vaccination. [Cukurova Med J 2015; 40(3.000: 517-524

  11. Knowledge Assessment of the Dental Community in Texas on the Role of Human Papilloma Virus in Oropharyngeal Cancer.

    Science.gov (United States)

    Rowan, Stephanie D; Hu, Shirley L; Brotzman, Jacob S; Redding, Spencer W; Rankin, K Vendrell; Vigneswaran, Nadarajah

    2015-08-01

    The epidemiology of oral cancer is changing. From 1988 to 2004, there has been a dramatic increase in Human Papilloma virus (HPV) positive oropharyngeal squamous cell carcinoma (OPC) in the U.S. At the same time there have been decreasing rates of OPC associated with the traditional risk factors of smoking and alcohol consumption. The epidemiology of oral cancer is changing. As the epidemiology changes, it is important that the dental community recognize these factors. The goal of this study was to assess the baseline level of knowledge about HPV and OPC within the Texas dental community. Practicing dentists and dental hygienists from Texas dental professional networks and dental students from the three Texas schools of dentistry were recruited to participate in the study. Participants were requested to access and complete a 7-item online survey. To ensure anonymity, a third party practice facilitator or department administrator disseminated the survey link to participants. Of the 457 surveys completed, 100% of respondents reported conducting oral soft tissue examinations at least annually. However, only 73% included the oropharynx in their exam. Less than 50% of dental professionals selected the correct location of the greatest increase in oral cancer incidence during the last 10 years. Less than 30% of each of the groups answered correctly in indicating the age group with the most rapidly increasing incidence of oral cancer. Approximately 40% of all groups indicated that a biopsy from the posterior oropharynx should be tested for HPV. Survey results across Texas dentists, dental hygienists, and Texas dental students demonstrated a lack of knowledge of the changing profile of oral cancer regarding HPV-associated OPC. This aim of this initial phase was to determine the baseline level of knowledge surrounding the risks associated with oropharyngeal cancer in the survey population. Our goal is to utilize these findings to develop educational interventions that will

  12. An Approach to "Knowledge,Thinking,Humanities" Reading Teaching%“知识·思维·人文”教学法初探

    Institute of Scientific and Technical Information of China (English)

    汪文新

    2012-01-01

    知识和思维能力体现的是工具特征,而人文素养体现的是对"人"的关怀。教学不仅要关注知识获得和思维训练,还应关注学生发展与人沟通和合作的能力,树立正确的人生观、世界观和价值观,增强社会责任感等人文素养。以提高人文素养为目标,以知识的输入和输出为基础,以思维能力的训练为核心的阅读教学就是"知识.思维.人文"教学法。%Knowledge and thinking skills are embodied as the teaching tool.Humanities are embodied in the form of "Human" care.Teaching should not only concern the access to knowledge and mental training,but also is concerned about the ability of students to develop communication and cooperation;establish a correct outlook on life,world outlook and values;enhance the sense of social responsibility and other humanities.Aim to enhancing the humanities,base on the input and output of knowledge and thinking skills training is used for the core teaching of reading.

  13. Biological knowledge-driven analysis of epistasis in human GWAS with application to lipid traits.

    Science.gov (United States)

    Ma, Li; Keinan, Alon; Clark, Andrew G

    2015-01-01

    While the importance of epistasis is well established, specific gene-gene interactions have rarely been identified in human genome-wide association studies (GWAS), mainly due to low power associated with such interaction tests. In this chapter, we integrate biological knowledge and human GWAS data to reveal epistatic interactions underlying quantitative lipid traits, which are major risk factors for coronary artery disease. To increase power to detect interactions, we only tested pairs of SNPs filtered by prior biological knowledge, including GWAS results, protein-protein interactions (PPIs), and pathway information. Using published GWAS and 9,713 European Americans (EA) from the Atherosclerosis Risk in Communities (ARIC) study, we identified an interaction between HMGCR and LIPC affecting high-density lipoprotein cholesterol (HDL-C) levels. We then validated this interaction in additional multiethnic cohorts from ARIC, the Framingham Heart Study, and the Multi-Ethnic Study of Atherosclerosis. Both HMGCR and LIPC are involved in the metabolism of lipids and lipoproteins, and LIPC itself has been marginally associated with HDL-C. Furthermore, no significant interaction was detected using PPI and pathway information, mainly due to the stringent significance level required after correcting for the large number of tests conducted. These results suggest the potential of biological knowledge-driven approaches to detect epistatic interactions in human GWAS, which may hold the key to exploring the role gene-gene interactions play in connecting genotypes and complex phenotypes in future GWAS.

  14. Factors Influencing Access to Integrated Soil Fertility Management Information and Knowledge and Its Uptake among Smallholder Farmers in Zimbabwe

    Science.gov (United States)

    Gwandu, T.; Mtambanengwe, F.; Mapfumo, P.; Mashavave, T. C.; Chikowo, R.; Nezomba, H.

    2014-01-01

    Purpose: The study evaluated how farmer acquisition, sharing and use patterns of information and knowledge interact with different socioeconomic factors to influence integrated soil fertility management (ISFM) technology uptake. Design/methodology/approach: The study was conducted as part of an evaluation of field-based farmer learning approaches…

  15. How Bioethics is Complementing Human Rights in Realizing Health Access for Clinical Trial Participants: The Case of Formative PrEP Access in South Africa.

    Science.gov (United States)

    Singh, Jerome

    2015-06-11

    Following the demise of apartheid, human rights in South Africa are now constitutionally enshrined.The right to health in South Africa's Constitution has been credited with transforming the lives of millions of people by triggering programmatic reforms in HIV treatment and the prevention of mother to child transmission (MTCT) of HIV.However, a constitutionally enshrined right to health offers no guarantee that clinical trial participants will enjoy post-trial access to beneficial interventions. Using access to HIV pre-exposure prophylaxis (PrEP) in South Africa as an example, this paper argues that adherence to bioethics norms could realize the right to health for trial participants following the end of a clinical trial.

  16. Multicenter Study of Human Papillomavirus and the Human Papillomavirus Vaccine: Knowledge and Attitudes among People of African Descent

    Directory of Open Access Journals (Sweden)

    Elizabeth Blackman

    2013-01-01

    Full Text Available Objective. To compare knowledge and attitudes of human papillomavirus (HPV and the vaccine between different cultures of African descent. Methods. A cross-sectional survey of 555 African-Americans and Afro-Caribbeans residing in the US and the Bahamas (BHM was conducted. Results. General knowledge about HPV and the HPV vaccine differed between the two countries significantly. Bahamian respondents were less likely to have higher numbers of correct knowledge answers when compared to Americans (Adjusted Odds Ratio [Adj. OR] 0.47, 95% Confidence Interval [CI] 0.30–0.75. Older age, regardless of location, was also associated with answering fewer questions correctly (Adj. OR 0.61, 95% CI 0.40–0.92. Attitudes related to HPV vaccination were similar between the US and BHM, but nearly 80% of BHM respondents felt that children should not be able to receive the vaccine without parental consent compared to 57% of American respondents. Conclusions. Grave lack of knowledge, safety and cost concerns, and influence of parental restrictions may negatively impact vaccine uptake among African-American and Afro-Caribbean persons. Interventions to increase the vaccine uptake in the Caribbean must include medical provider and parental involvement. Effective strategies for education and increasing vaccine uptake in BHM are crucial for decreasing cervical cancer burden in the Caribbean.

  17. Knowledge and Attitudes About Human Papilloma Virus (HPV) Vaccination and Cervical Cancer Screening Among Women in Rural Uganda

    Science.gov (United States)

    2016-06-15

    is unlimited. UNCLASSIFIED -13- 17. Asiimwe, s. Predictors of high - risk human papillomavirus infection, a Population based study in rural, Uganda...1- Knowledge and attitudes about Human Papilloma Virus (HPV) vaccination and cervical cancer screening among women in rural Uganda Authors...Oncogenic Human Papilloma virus (HPV) strains 16 and 18. While cervical cancer is widely understood as a fatal disease, knowledge and awareness of

  18. Access to abortion services: the impact of the European convention on human rights in Ireland.

    Science.gov (United States)

    Daly, Brenda

    2011-06-01

    Abortion is unlawful in Ireland except where it is necessary to save the life of the mother. The right to life of the unborn child is safeguarded under Article 40.3.3 degrees of Bunreacht na hEireann (the Irish Constitution). In 2003 the European Convention on Human Rights was incorporated into Irish domestic legislation, subject to the provisions of the Irish Constitution. The aim of this paper is to consider the potential impact of the ECHR on access to abortion services within the State. This paper commences with discussion of the statutory prohibition on abortion and the Constitutional provisions concerning the protection afforded to the unborn child. It will then be necessary to examine the implications for Ireland of recent European Court of Human Rights' decisions, in particular the recent judgment in A, B & C v Ireland, regarding the right to legal abortions given the unique nature of the legal status of the ECHR and its relationship with the Irish Constitution.

  19. The development of human behavior analysis techniques - A study on knowledge representation methods for operator cognitive model

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Woon; Park, Young Tack [Soongsil University, Seoul (Korea, Republic of)

    1996-07-01

    The main objective of this project is modeling of human operator in a main control room of Nuclear Power Plant. For this purpose, we carried out research on knowledge representation and inference method based on Rasmussen`s decision ladder structure. And we have developed SACOM(Simulation= Analyzer with a Cognitive Operator Model) using G2 shell on Sun workstations. SACOM consists of Operator Model, Interaction Analyzer, Situation Generator. Cognitive model aims to build a more detailed model of human operators in an effective way. SACOM is designed to model knowledge-based behavior of human operators more easily. The followings are main research topics carried out this year. First, in order to model knowledge-based behavior of human operators, more detailed scenarios are constructed. And, knowledge representation and inference methods are developed to support the scenarios. Second, meta knowledge structures are studied to support human operators 4 types of diagnoses. This work includes a study on meta and scheduler knowledge structures for generate-and-test, topographic, decision tree and case-based approaches. Third, domain knowledge structure are improved to support meta knowledge. Especially, domain knowledge structures are developed to model topographic diagnosis model. Fourth, more applicable interaction analyzer and situation generator are designed and implemented. The new version is implemented in G2 on Sun workstations. 35 refs., 49 figs. (author)

  20. The impact of Body Worlds on adult visitors' knowledge on human anatomy: A preliminary study.

    Science.gov (United States)

    Fonseca, Guilherme R B C; Finn, Gabrielle M

    2016-05-01

    Body Worlds is an anatomical exhibition that shows human remains to the public. It has been considered controversial since it raises ethical tensions and issues. However, organizers and supporters of Body Worlds have claimed the exhibition is intended to promote visitors' understanding over the human body. Despite these claims, no studies were found that support or refute the hypothesis that a visit to Body Worlds increases the public's objective knowledge on human anatomy. Consequently, the objective of this study was to determine the impact of Body Worlds on anatomical knowledge. We constructed and delivered a questionnaire to both a previsit random sample and a postvisit random sample of visitors of Body Worlds' event Facets of Life, in Berlin. The questionnaire was available in both English and German languages and contained (a) basic sociodemographic questions and (b) a valid and reliable anatomy quiz. The quiz consisted of 16 multiple-choice questions that assessed the ability to identify the location of major anatomical structures on the human body. Average scores achieved on the quiz by the postvisit sample (X¯= 9.08, s = 2.48, n = 164) were significantly higher (unpaired t = 3.3957, P = 0.0008) than those achieved by the previsit sample (X¯= 8.11, s = 2.69, n = 167). Our results suggest that a visit to Body Worlds' event Facets of Life may have a beneficial effect in anatomical knowledge. However, further studies with better empirical designs and fewer limitations are needed to confirm our results.

  1. Innovative Knowledge Management At Disney: Human Capital And Queuing Solutions For Services

    Directory of Open Access Journals (Sweden)

    Rachelle F. Cope

    2011-04-01

    Full Text Available It is well known that most activities in which a service is provided require customers to wait in a queue during the experience. One thing that is inherent in waiting lines is the universal dislike for the process. In fact, the feelings and opinions developed in waiting lines influence the customer’s perception of the awaited experience. In this paper, Disney is used as a case study for queuing solutions. In particular, we examine their implementation of Knowledge Management (KM solutions to improve the waiting line process. The use of Disney cast members as human capital combined with the knowledge of customer preferences has made the FASTPASS an innovative solution to enhance queuing in the Disney theme parks. In the past, KM has been thought of as the collection of technological assets and managerial policies that compensate for information failures. In fact, the individual’s need for human interaction provides the richest opportunity for knowledge acquisition. Disney’s ability to capture customers in virtual queues while giving them a pleasurable waiting experience has made them a leader in KM initiatives in the service industry.

  2. Extraction of the human cerebral ventricular system from MRI: inclusion of anatomical knowledge and clinical perspective

    Science.gov (United States)

    Aziz, Aamer; Hu, Qingmao; Nowinski, Wieslaw L.

    2004-04-01

    The human cerebral ventricular system is a complex structure that is essential for the well being and changes in which reflect disease. It is clinically imperative that the ventricular system be studied in details. For this reason computer assisted algorithms are essential to be developed. We have developed a novel (patent pending) and robust anatomical knowledge-driven algorithm for automatic extraction of the cerebral ventricular system from MRI. The algorithm is not only unique in its image processing aspect but also incorporates knowledge of neuroanatomy, radiological properties, and variability of the ventricular system. The ventricular system is divided into six 3D regions based on the anatomy and its variability. Within each ventricular region a 2D region of interest (ROI) is defined and is then further subdivided into sub-regions. Various strict conditions that detect and prevent leakage into the extra-ventricular space are specified for each sub-region based on anatomical knowledge. Each ROI is processed to calculate its local statistics, local intensity ranges of cerebrospinal fluid and grey and white matters, set a seed point within the ROI, grow region directionally in 3D, check anti-leakage conditions and correct growing if leakage occurs and connects all unconnected regions grown by relaxing growing conditions. The algorithm was tested qualitatively and quantitatively on normal and pathological MRI cases and worked well. In this paper we discuss in more detail inclusion of anatomical knowledge in the algorithm and usefulness of our approach from clinical perspective.

  3. Knowledge, attitude, and beliefs of young, college student blood donors about Human immunodeficiency virus

    Directory of Open Access Journals (Sweden)

    Anju Dubey

    2014-01-01

    Full Text Available Introduction: Young people, who tend to be healthy, idealistic, and motivated, are an excellent pool of potential voluntary unpaid blood donors. Recruiting and retaining young blood donors improves the long term safety and sufficiency of a country′s blood supply. Knowledge, attitude, and beliefs about Human immunodeficiency virus (HIV should play an important role in prevention of disease transmission. Materials and Methods: This study was a questionnaire based survey, conducted to explore the levels of knowledge, attitude, and beliefs about HIV in young college student blood donors. Results: The results showed that the proportion of participants with comprehensive knowledge of HIV prevention and transmission was lesser than expected. Increase in education level and male gender was found to be significantly associated with high HIV-related knowledge. The responses on the different aspects of HIV-related attitude were also varied and there is still stigma associated with Acquired Immunodeficiency Syndrome (AIDS even in the educated groups. Discussion: There was a spectrum of myths and misperceptions emphasizing the need of education that recognizes the social context of attitude towards HIV. Results from this study may contribute to the development of appropriate educational and training material for this group of donors which in turn, may assist in achieving the elusive goal of safe blood supply in future.

  4. Setting health research priorities using the CHNRI method: V. Quantitative properties of human collective knowledge.

    Science.gov (United States)

    Rudan, Igor; Yoshida, Sachiyo; Wazny, Kerri; Chan, Kit Yee; Cousens, Simon

    2016-06-01

    The CHNRI method for setting health research priorities has crowdsourcing as the major component. It uses the collective opinion of a group of experts to generate, assess and prioritize between many competing health research ideas. It is difficult to compare the accuracy of human individual and collective opinions in predicting uncertain future outcomes before the outcomes are known. However, this limitation does not apply to existing knowledge, which is an important component underlying opinion. In this paper, we report several experiments to explore the quantitative properties of human collective knowledge and discuss their relevance to the CHNRI method. We conducted a series of experiments in groups of about 160 (range: 122-175) undergraduate Year 2 medical students to compare their collective knowledge to their individual knowledge. We asked them to answer 10 questions on each of the following: (i) an area in which they have a degree of expertise (undergraduate Year 1 medical curriculum); (ii) an area in which they likely have some knowledge (general knowledge); and (iii) an area in which they are not expected to have any knowledge (astronomy). We also presented them with 20 pairs of well-known celebrities and asked them to identify the older person of the pair. In all these experiments our goal was to examine how the collective answer compares to the distribution of students' individual answers. When answering the questions in their own area of expertise, the collective answer (the median) was in the top 20.83% of the most accurate individual responses; in general knowledge, it was in the top 11.93%; and in an area with no expertise, the group answer was in the top 7.02%. However, the collective answer based on mean values fared much worse, ranging from top 75.60% to top 95.91%. Also, when confronted with guessing the older of the two celebrities, the collective response was correct in 18/20 cases (90%), while the 8 most successful individuals among the

  5. [The global and national context regarding the challenges involved in ensuring adequate access to water for human consumption].

    Science.gov (United States)

    Augusto, Lia Giraldo da Silva; Gurgel, Idê Gomes Dantas; Câmara Neto, Henrique Fernandes; de Melo, Carlos Henrique; Costa, André Monteiro

    2012-06-01

    The scope of this article is to analyze the challenges involved in ensuring access to water for human consumption taking the international and national context into consideration. Based on the UN declaration that access to safe and clean drinking water is a fundamental human right, vulnerabilities are identified that can consist in restrictions to access to adequate supplies. The distribution of water and the population across the planet, pollution, inadequate policies and management lead to environmental injustice. The iniquity of access to water constitutes the contemporary water crisis. From the 1980s onwards, the transnational water market emerged for private control that occurs at three main levels: surface and underground water sources; bottled water; and public water supply services. The conflicts of the multiple uses of water resources, the market and environmental problems have contributed to rendering the health of the population and ecosystems vulnerable. Adequate public policies are essential to ensure the basic human right to access to safe and clean drinking water.

  6. Young Australian adults with NF1 have poor access to health care, high complication rates, and limited disease knowledge.

    Science.gov (United States)

    Oates, Emily C; Payne, Jonathan M; Foster, Sheryl L; Clarke, Nigel F; North, Kathryn N

    2013-04-01

    Neurofibromatosis type 1 (NF1) is a multisystem disease associated with a lifelong risk of debilitating and potentially life-limiting complications, however many adults with NF1 have no regular health surveillance. We interviewed and examined 17 young adults with NF1 between the ages of 25 and 33. Most had not been assessed for NF1-related complications within the previous 8 years, including patients with known serious vascular complications, for example, renal artery stenosis. Acute and/or chronic pain, particularly back and plexiform-related pain were common symptoms, and despite a significant impact on quality of life, was untreated in most instances. Symptom and examination-directed imaging revealed serious complications in 41% of the cohort. These included severe spinal cord compression (two cases), a highly SUV avid lesion suggestive of malignancy (one case), and a Juvenile Pilocytic Astrocytoma in a patient without any previous NF1-related complications. Few study participants had a good understanding of NF1, its associated risks and complications, and many had not sought appropriate medical advice as questions or problems arose. NF1-related cognitive deficits in some participants, and the lack of a clear source of expert medical advice for adults with NF1 likely contributed to poor health surveillance and management in this population. Overall, these findings suggest that many Australian adults with NF1 are at risk of serious and life-threatening medical complications, but are not accessing and receiving adequate health care. Access to multidisciplinary adult clinics that specialize in NF1 may address many of the unmet health needs of young adults with NF1.

  7. Assessment of entrepreneurship pedagogy on entrepreneurship knowledge and entrepreneurial human capital asset: A conceptual model

    Directory of Open Access Journals (Sweden)

    Chidimma Odira Okeke

    2016-06-01

    Full Text Available This study is an effort to propose a conceptual model to measure the impact assessment of entrepreneurship pedagogic. It delineates entrepreneurship education pedagogic into four dimensions and opined specific level for each dimension. Reviewing the entrepreneurship education programme, assessment of entrepreneurship pedagogic evaluates the structure that influence growth mindset development through embedded heuristic strategies, thus, the impact on entrepreneurship knowledge and entrepreneurial capital asset context is proposed. Affirming Fayolle, Gailly, and Lassa-Clerc conceptual affinity that entrepreneurship education share with learning theories and entrepreneurship pedagogical content knowledge were conceptualized to suggest some practical realism guidelines of what insightful philosophy of teaching entrepreneurship need to achieve. With direct synthesis of relevant literature, propositions relating to entrepreneurship pedagogic structure along with the institutional connectedness and associated dimensions of entrepreneurship pedagogic assessment outcome were postulated. Also, the paper proposes the need for further assessment of specific forms of pedagogic impact on entrepreneurial human capital asset.

  8. Organizing Conceptual Knowledge in Humans with a Grid-like Code

    Science.gov (United States)

    Behrens, Timothy E. J.

    2017-01-01

    It has been hypothesized that the brain organizes concepts into a mental map, allowing conceptual relationships to be navigated in a similar fashion to space. Grid cells use a hexagonally-symmetric code to organize spatial representations and are the likely source of a precise hexagonal symmetry in the functional magnetic resonance imaging signal. Humans navigating conceptual two-dimensional knowledge showed the same hexagonal signal in a strikingly similar set of brain regions to those activated during spatial navigation. This grid-like signal is consistent across sessions acquired within an hour and more than a week apart. Our findings suggest that global relational codes may be used to organize non-spatial conceptual representations and that these codes may have hexagonal grid-like pattern when conceptual knowledge is laid out in two continuous dimensions. PMID:27313047

  9. Controlled human malaria infection trials: How tandems of trust and control construct scientific knowledge.

    Science.gov (United States)

    Bijker, Else M; Sauerwein, Robert W; Bijker, Wiebe E

    2016-02-01

    Controlled human malaria infections are clinical trials in which healthy volunteers are deliberately infected with malaria under controlled conditions. Controlled human malaria infections are complex clinical trials: many different groups and institutions are involved, and several complex technologies are required to function together. This functioning together of technologies, people, and institutions is under special pressure because of potential risks to the volunteers. In this article, the authors use controlled human malaria infections as a strategic research site to study the use of control, the role of trust, and the interactions between trust and control in the construction of scientific knowledge. The authors argue that tandems of trust and control play a central role in the successful execution of clinical trials and the construction of scientific knowledge. More specifically, two aspects of tandems of trust and control will be highlighted: tandems are sites where trust and control coproduce each other, and tandems link the personal, the technical, and the institutional domains. Understanding tandems of trust and control results in setting some agendas for both clinical trial research and science and technology studies.

  10. Knowledge, attitude, and uptake related to human papillomavirus vaccination among young women in Germany recruited via a social media site.

    Science.gov (United States)

    Remschmidt, Cornelius; Walter, Dietmar; Schmich, Patrick; Wetzstein, Matthias; Deleré, Yvonne; Wichmann, Ole

    2014-01-01

    Many industrialized countries have introduced human papillomavirus (HPV) vaccination of young women, but vaccine uptake often remains suboptimal. This study aimed to investigate whether a social media site like Facebook is an appropriate tool to assess knowledge, attitude and uptake related to HPV vaccination in young women in Germany. Between December 2012 and January 2013 two different targeting strategies were implemented on Facebook, providing a link to an online questionnaire. Advertisements were displayed to female Facebook users aged 18-25 years living in Germany. During the simple targeting strategy, advertisements comprised health-related images along with various short titles and text messages. During the focused strategy, advertisements were targeted to users who in addition had certain fashion brands or pop stars listed on their profiles. The targeting strategies were compared with respect to participant characteristics. Univariate and multivariate analyses were used to identify factors associated with HPV vaccine uptake. A total of 1161 women participated. The two targeting strategies resulted in significant differences regarding educational status and migrant background. Overall, awareness of HPV was high, but only 53% received at least one vaccine dose. In multivariate analysis, HPV vaccine uptake was independently associated with a physician's recommendation and trust in vaccine effectiveness. Concerns of adverse effects were negatively associated with vaccine uptake. Social network recruitment permits fast and convenient access to young people. Sample characteristics can be manipulated by adjusting targeting strategies. There is further need for promoting knowledge of HPV vaccination among young women. Physicians have a major role in the vaccination decision-making process of young women.

  11. Integration of preclinical and clinical knowledge to predict intravenous PK in human: bilastine case study.

    Science.gov (United States)

    Vozmediano, Valvanera; Ortega, Ignacio; Lukas, John C; Gonzalo, Ana; Rodriguez, Monica; Lucero, Maria Luisa

    2014-03-01

    Modern pharmacometrics can integrate and leverage all prior proprietary and public knowledge. Such methods can be used to scale across species or comparators, perform clinical trial simulation across alternative designs, confirm hypothesis and potentially reduce development burden, time and costs. Crucial yet typically lacking in integration is the pre-clinical stage. Prediction of PK in man, using in vitro and in vivo studies in different animal species, is increasingly well theorized but could still find wider application in drug development. The aim of the present work was to explore methods for bridging pharmacokinetic knowledge from animal species (i.v. and p.o.) and man (p.o.) into i.v. in man using the antihistamine drug bilastine as example. A model, predictive of i.v. PK in man, was developed on data from two pre-clinical species (rat and dog) and p.o. in man bilastine trials performed earlier. In the knowledge application stage, two different approaches were used to predict human plasma concentration after i.v. of bilastine: allometry (several scaling methods) and a semi-physiological method. Both approaches led to successful predictions of key i.v. PK parameters of bilastine in man. The predictive i.v. PK model was validated using later data from a clinical study of i.v. bilastine. Introduction of such knowledge in development permits proper leveraging of all emergent knowledge as well as quantification-based exploration of PK scenario, e.g. in special populations (pediatrics, renal insufficiency, comedication). In addition, the methods permit reduction or elimination and certainly optimization of learning trials, particularly those concerning alternative off-label administration routes.

  12. What impact has England's Teenage Pregnancy Strategy had on young people's knowledge of and access to contraceptive services?

    Science.gov (United States)

    French, Rebecca S; Mercer, Catherine H; Kane, Roslyn; Kingori, Patricia; Stephenson, Judith M; Wilkinson, Paul; Grundy, Chris; Lachowycz, Kate; Jacklin, Paul; Stevens, Maryjane; Brooker, Sue; Wellings, Kaye

    2007-12-01

    To describe young people's knowledge and use of contraceptive services over initial stages of England's Teenage Pregnancy Strategy, and to investigate factors associated with use of different services. A random location sample of young people aged 13-21 years (n = 8879) was interviewed in 12 waves over 2000-2004. Individual data were analysed to investigate factors associated with knowledge and use of contraceptive services and to observe trends over time. Area-level data were analyzed to explore differences in key variables. In all, 77% of young women and 65% of young men surveyed knew a service they could use to obtain information about sex. Amongst those who had had vaginal sexual intercourse, the most common source of contraceptive supplies was general practice for young women (54%) and commercial venues for young men (54%). Young women's use of school-based services to obtain supplies increased significantly from 15.4% in Year 1 to 24.4% in Year 4, p < .001. Young men's use of the commercial sector declined significantly over the same time period (60.3% to 50.6%, p = .002), while their use of general practice and family planning clinics increased (from 8.9% to 12.4%, p = .008, and 21.2% to 29.1%, p = .054, respectively). Use of family planning clinics and designated young people's clinics was associated with first vaginal intercourse before the 16th birthday and living in a deprived area. Young people's patterns of contraceptive service use have changed since implementation of the Strategy; although no increase in overall service use was observed. The contribution of school-based services needs further exploration.

  13. A survey to access knowledge and practice among dentists regarding local anesthetic dosage in three cities of Uttarakhand

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    Laxman Singh Kaira

    2014-01-01

    Full Text Available Objective: Local anesthetics are the most commonly used drugs in routine dentistry. Although they are considered effective and safe in controlling pain during dental procedures, complications related to their use appear inevitable. Many dentists use these drugs routinely but are unaware of the dose calculations required and the maximum safe and effective dose of the drug. Materials and Methods: This study was aimed to determine the knowledge that general dental practitioners and dental specialists, in three different cities in India, have regarding dose calculations and the maximum-dose required of the most commonly used local anesthetics. A one page survey questionnaire was used in this study and data were analyzed using standard SPSS statistical program version 11, software (SPSS Inc. Chicago, Illinois, USA. Results: The respondents comprised 71.4% general dental practitioners and 28.5% dental specialists, with ages ranging from 26 to 50 years; Nearly 75% of the total respondent was males and 25% females. Nearly 69% of the respondents were unaware of the maximum recommended dose for use on adult, healthy patients and 81% were still confused about the maximum numbers of syringes containing 2% lignocaine with adrenaline that can be given to a patient. A total of 49% of general dental practitioners and specialists do not perform aspiration when injecting local anesthetics, whereas only 38% performed the aspiration in inferior nerve block technique, while only 12% performed aspiration in all types of injection techniques. A high percentage of the dentists (84% who responded are unaware of how to calculate the local anesthetic dose and 31% of them encountered complications during, or after, local anesthetic administration. Conclusion: General practitioners and dental specialists appear to have an inadequate knowledge about local anesthetics maximum-dose and dose calculations; further educational courses are recommended to update them regarding such

  14. Relationship between Fidelity and Dose of Human Patient Simulation, Critical Thinking Skills, and Knowledge in an Associate Degree Nursing Program

    Science.gov (United States)

    Beebe, Rosella I.

    2012-01-01

    This study examined the relationship between human patient simulation (HPS), critical thinking skills, and knowledge acquisition after HPS was integrated across the curriculum of an associate degree nursing program to determine if differences existed in critical thinking and knowledge of students based on the fidelity of HPS used and amount of…

  15. Association of Cervical Cancer Screening with Knowledge of Risk Factors, Access to Health Related Information, Health Profiles, and Health Competence Beliefs among Community-Dwelling Women in Japan

    Science.gov (United States)

    Oba, Shino; Toyoshima, Masato; Ogata, Hiromitsu

    2017-08-27

    Objective: The aim of this study was to evaluate the past attendance for cervical cancer screening with knowledge of risk factors, access to health-related information, health profiles and health competence beliefs among Japanese women. Methods: Women ages 25, 30, 35, 40, 45, 50, 55, and 60 were contacted cross-sectionally as part of a project for the Japanese Ministry of Health, Labour and Welfare in Nikaho, Akita prefecture Japan between June 2010 and March 2011, and 249 women were analyzed for the current study. The questionnaire asked about past cervical cancer screening. Knowledge of each cervical cancer risk factor was determined on a four-point scale. A barriers to information access scale was utilized to assess the degree of difficulty in accessing health-related information. Health profiles were measured using the EuroQOL EQ-5D. Perceived health competence was measured using a scale (PHCS). The association was evaluated with odds ratios with 95% confidence interval were calculated from a logistic regression analysis after adjustment for age and potential confounders. The trend across the level was also assessed. Results: Women who knew that sexual intercourse at young age was a risk factor were significantly more likely to have participated in cervical cancer screening sometime in their lives (p for trend =0.02). Women who had pain/discomfort and those who had anxiety/depression were significantly more likely to have participated in cervical screening within the past two years (odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.04–3.94; OR: 2.32, 95% CI: 1.05–5.16, respectively). Women with higher PHCS were significantly more likely to have attended for cervical screened at some point in their lives (p=0.04). Conclusion: This study observed that specific knowledge of cervical cancer risk factors, health profiles and PHCS were associated with the past attendance for cervical cancer screening among women in a community. Further researches are

  16. A knowledge based approach to matching human neurodegenerative disease and animal models

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    Maryann E Martone

    2013-05-01

    Full Text Available Neurodegenerative diseases present a wide and complex range of biological and clinical features. Animal models are key to translational research, yet typically only exhibit a subset of disease features rather than being precise replicas of the disease. Consequently, connecting animal to human conditions using direct data-mining strategies has proven challenging, particularly for diseases of the nervous system, with its complicated anatomy and physiology. To address this challenge we have explored the use of ontologies to create formal descriptions of structural phenotypes across scales that are machine processable and amenable to logical inference. As proof of concept, we built a Neurodegenerative Disease Phenotype Ontology and an associated Phenotype Knowledge Base using an entity-quality model that incorporates descriptions for both human disease phenotypes and those of animal models. Entities are drawn from community ontologies made available through the Neuroscience Information Framework and qualities are drawn from the Phenotype and Trait Ontology. We generated ~1200 structured phenotype statements describing structural alterations at the subcellular, cellular and gross anatomical levels observed in 11 human neurodegenerative conditions and associated animal models. PhenoSim, an open source tool for comparing phenotypes, was used to issue a series of competency questions to compare individual phenotypes among organisms and to determine which animal models recapitulate phenotypic aspects of the human disease in aggregate. Overall, the system was able to use relationships within the ontology to bridge phenotypes across scales, returning non-trivial matches based on common subsumers that were meaningful to a neuroscientist with an advanced knowledge of neuroanatomy. The system can be used both to compare individual phenotypes and also phenotypes in aggregate. This proof of concept suggests that expressing complex phenotypes using formal

  17. A knowledge based approach to matching human neurodegenerative disease and animal models

    Science.gov (United States)

    Maynard, Sarah M.; Mungall, Christopher J.; Lewis, Suzanna E.; Imam, Fahim T.; Martone, Maryann E.

    2013-01-01

    Neurodegenerative diseases present a wide and complex range of biological and clinical features. Animal models are key to translational research, yet typically only exhibit a subset of disease features rather than being precise replicas of the disease. Consequently, connecting animal to human conditions using direct data-mining strategies has proven challenging, particularly for diseases of the nervous system, with its complicated anatomy and physiology. To address this challenge we have explored the use of ontologies to create formal descriptions of structural phenotypes across scales that are machine processable and amenable to logical inference. As proof of concept, we built a Neurodegenerative Disease Phenotype Ontology (NDPO) and an associated Phenotype Knowledge Base (PKB) using an entity-quality model that incorporates descriptions for both human disease phenotypes and those of animal models. Entities are drawn from community ontologies made available through the Neuroscience Information Framework (NIF) and qualities are drawn from the Phenotype and Trait Ontology (PATO). We generated ~1200 structured phenotype statements describing structural alterations at the subcellular, cellular and gross anatomical levels observed in 11 human neurodegenerative conditions and associated animal models. PhenoSim, an open source tool for comparing phenotypes, was used to issue a series of competency questions to compare individual phenotypes among organisms and to determine which animal models recapitulate phenotypic aspects of the human disease in aggregate. Overall, the system was able to use relationships within the ontology to bridge phenotypes across scales, returning non-trivial matches based on common subsumers that were meaningful to a neuroscientist with an advanced knowledge of neuroanatomy. The system can be used both to compare individual phenotypes and also phenotypes in aggregate. This proof of concept suggests that expressing complex phenotypes using formal

  18. Representing Human Expertise by the OWL Web Ontology Language to Support Knowledge Engineering in Decision Support Systems.

    Science.gov (United States)

    Ramzan, Asia; Wang, Hai; Buckingham, Christopher

    2014-01-01

    Clinical decision support systems (CDSSs) often base their knowledge and advice on human expertise. Knowledge representation needs to be in a format that can be easily understood by human users as well as supporting ongoing knowledge engineering, including evolution and consistency of knowledge. This paper reports on the development of an ontology specification for managing knowledge engineering in a CDSS for assessing and managing risks associated with mental-health problems. The Galatean Risk and Safety Tool, GRiST, represents mental-health expertise in the form of a psychological model of classification. The hierarchical structure was directly represented in the machine using an XML document. Functionality of the model and knowledge management were controlled using attributes in the XML nodes, with an accompanying paper manual for specifying how end-user tools should behave when interfacing with the XML. This paper explains the advantages of using the web-ontology language, OWL, as the specification, details some of the issues and problems encountered in translating the psychological model to OWL, and shows how OWL benefits knowledge engineering. The conclusions are that OWL can have an important role in managing complex knowledge domains for systems based on human expertise without impeding the end-users' understanding of the knowledge base. The generic classification model underpinning GRiST makes it applicable to many decision domains and the accompanying OWL specification facilitates its implementation.

  19. Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer

    OpenAIRE

    Nicholas C. Gomez; Austin J. Hepperla; Raluca Dumitru; Jeremy M. Simon; Fang Fang; Ian J. Davis

    2016-01-01

    Chromatin regulation is critical for differentiation and disease. However, features linking the chromatin environment of stem cells with disease remain largely unknown. We explored chromatin accessibility in embryonic and multipotent stem cells and unexpectedly identified widespread chromatin accessibility at repetitive elements. Integrating genomic and biochemical approaches, we demonstrate that these sites of increased accessibility are associated with well-positioned nucleosomes marked by ...

  20. Knowledge and beliefs regarding human papillomavirus among college nursing students at a minority-serving institution.

    Science.gov (United States)

    Schmotzer, Geri L; Reding, Kerryn W

    2013-12-01

    Cervical cancer is a leading cause of death in US women, with Hispanic women at higher risk of mortality than non-Hispanic white women. While the human papillomavirus (HPV) vaccine represents substantial progress towards cervical cancer prevention, little is currently known about Hispanic student's beliefs regarding the HPV vaccine. To assess the knowledge, attitudes, behaviors, and beliefs of college students in the US-Mexico border region following the release of the HPV vaccine for both males and females. This survey was conducted using a convenience sample were participants were recruited from pre-nursing and nursing courses. The self-administered questionnaire ascertained HPV vaccination status, and knowledge and beliefs regarding the HPV vaccine. 202 male and female students responded. 28.9% of respondents reported having received the HPV vaccine. Of the non-vaccinated students under age 27, 27.3% Hispanic students reported an intention to receive the vaccine. Misinformation about HPV was common and was associated with intention to get vaccinated among non-Hispanic white students. We found a relatively small proportion of unvaccinated Hispanic and non-Hispanic nursing students intend to be vaccinated for HPV. Findings indicate an intervention to increase vaccination rates among college-aged students may not be as straightforward as increasing knowledge of HPV. Nurses are in a unique position to educate and recommend HPV to underserved patients. Thus, educating nursing students regarding HPV and the associated cancers is paramount if we are to encourage ethnic minorities to receive the HPV vaccine.

  1. Pediatricians' intention to administer human papillomavirus vaccine: the role of practice characteristics, knowledge, and attitudes.

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    Kahn, Jessica A; Zimet, Gregory D; Bernstein, David I; Riedesel, Jeremy M; Lan, Dongmei; Huang, Bin; Rosenthal, Susan L

    2005-12-01

    The objective of this study was to examine pediatrician characteristics and attitudes associated with intention to recommend two hypothetical human papillomavirus (HPV) vaccines. A survey instrument mailed to a random sample of 1000 pediatricians assessed provider characteristics, HPV knowledge, and attitudes about HPV vaccination. Intention to administer each of two HPV vaccines types (a cervical cancer/genital wart vaccine and a cervical cancer vaccine) to girls and boys of three different ages (11, 14, and 17 years) was assessed. Linear mixed modeling for repeated measures and multivariable linear regression models were performed to identify variables associated with intention to recommend vaccination. The mean age of participants (n = 513) was 42 years and 57% were female. Participants were more likely to recommend vaccination to girls vs. boys and older vs. younger children, and were more likely to recommend a cervical cancer/genital wart vaccine than a cervical cancer vaccine (p HPV knowledge (beta 1.079, p = .015), likelihood of following the recommendations of important individuals and organizations regarding immunization (beta .834, p = .001), and fewer perceived barriers to immunization (beta -.203, p = .001). Vaccination initiatives directed toward pediatricians that focus on modifiable predictors of intention to vaccinate, such as HPV knowledge and attitudes about vaccination, may facilitate adherence to emerging national immunization guidelines.

  2. SymbioGenomesDB: a database for the integration and access to knowledge on host-symbiont relationships.

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    Reyes-Prieto, Mariana; Vargas-Chávez, Carlos; Latorre, Amparo; Moya, Andrés

    2015-01-01

    Symbiotic relationships occur naturally throughout the tree of life, either in a commensal, mutualistic or pathogenic manner. The genomes of multiple organisms involved in symbiosis are rapidly being sequenced and becoming available, especially those from the microbial world. Currently, there are numerous databases that offer information on specific organisms or models, but none offer a global understanding on relationships between organisms, their interactions and capabilities within their niche, as well as their role as part of a system, in this case, their role in symbiosis. We have developed the SymbioGenomesDB as a community database resource for laboratories which intend to investigate and use information on the genetics and the genomics of organisms involved in these relationships. The ultimate goal of SymbioGenomesDB is to host and support the growing and vast symbiotic-host relationship information, to uncover the genetic basis of such associations. SymbioGenomesDB maintains a comprehensive organization of information on genomes of symbionts from diverse hosts throughout the Tree of Life, including their sequences, their metadata and their genomic features. This catalog of relationships was generated using computational tools, custom R scripts and manual integration of data available in public literature. As a highly curated and comprehensive systems database, SymbioGenomesDB provides web access to all the information of symbiotic organisms, their features and links to the central database NCBI. Three different tools can be found within the database to explore symbiosis-related organisms, their genes and their genomes. Also, we offer an orthology search for one or multiple genes in one or multiple organisms within symbiotic relationships, and every table, graph and output file is downloadable and easy to parse for further analysis. The robust SymbioGenomesDB will be constantly updated to cope with all the data being generated and included in major

  3. Human resources needs for universal access to antiretroviral therapy in South Africa: a time and motion study

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    Hontelez Jan AC

    2012-10-01

    Full Text Available Abstract Background Although access to life-saving treatment for patients infected with HIV in South Africa has improved substantially since 2004, treating all eligible patients (universal access remains elusive. As the prices of antiretroviral drugs have dropped over the past years, availability of human resources may now be the most important barrier to achieving universal access to HIV treatment in Africa. We quantify the number of HIV health workers (HHWs required to be added to the current HIV workforce to achieve universal access to HIV treatment in South Africa, under different eligibility criteria. Methods We performed a time and motion study in three HIV clinics in a rural, primary care-based HIV treatment program in KwaZulu-Natal, South Africa, to estimate the average time per patient visit for doctors, nurses, and counselors. We estimated the additional number of HHWs needed to achieve universal access to HIV treatment within one year. Results For universal access to HIV treatment for all patients with a CD4 cell count of ≤350 cells/μl, an additional 2,200 nurses, 3,800 counselors, and 300 doctors would be required, at additional annual salary cost of 929 million South African rand (ZAR, equivalent to US$ 141 million. For universal treatment (‘treatment as prevention’, an additional 6,000 nurses, 11,000 counselors, and 800 doctors would be required, at an additional annual salary cost of ZAR 2.6 billion (US$ 400 million. Conclusions Universal access to HIV treatment for patients with a CD4 cell count of ≤350 cells/μl in South Africa may be affordable, but the number of HHWs available for HIV treatment will need to be substantially increased. Treatment as prevention strategies will require considerable additional financial and human resources commitments.

  4. Using imagery perspective to access two distinct forms of self-knowledge: associative evaluations versus propositional self-beliefs.

    Science.gov (United States)

    Libby, Lisa K; Valenti, Greta; Hines, Karen A; Eibach, Richard P

    2014-04-01

    When mentally simulating life events, people may visualize them from either an actor's 1st-person or observer's 3rd-person visual perspective. Two experiments demonstrated that visual perspective differentially determines reliance on 2 distinct forms of self-knowledge: associative evaluations of the simulated environment and propositional self-beliefs about relevant values and preferences. Implicit measures indexed associative evaluations of environmental stimuli (political candidates, outgroups); explicit measures indexed propositional self-beliefs about relevant personal values or preferences. A separate session manipulated participants' visual perspective for mentally simulating a pertinent event (voting, interracial interaction) as they forecasted their behavior or feelings if that event occurred. Forecasts corresponded more closely with associative evaluations from the 1st-person than 3rd-person perspective but more closely with propositional self-beliefs from the 3rd-person than 1st-person. Results have practical implications for channeling the power of mental simulation to desired ends and theoretical implications for understanding the pathways by which imagery and mental simulation shape cognition.

  5. A decade of human genome project conclusion: Scientific diffusion about our genome knowledge.

    Science.gov (United States)

    Moraes, Fernanda; Góes, Andréa

    2016-05-06

    The Human Genome Project (HGP) was initiated in 1990 and completed in 2003. It aimed to sequence the whole human genome. Although it represented an advance in understanding the human genome and its complexity, many questions remained unanswered. Other projects were launched in order to unravel the mysteries of our genome, including the ENCyclopedia of DNA Elements (ENCODE). This review aims to analyze the evolution of scientific knowledge related to both the HGP and ENCODE projects. Data were retrieved from scientific articles published in 1990-2014, a period comprising the development and the 10 years following the HGP completion. The fact that only 20,000 genes are protein and RNA-coding is one of the most striking HGP results. A new concept about the organization of genome arose. The ENCODE project was initiated in 2003 and targeted to map the functional elements of the human genome. This project revealed that the human genome is pervasively transcribed. Therefore, it was determined that a large part of the non-protein coding regions are functional. Finally, a more sophisticated view of chromatin structure emerged. The mechanistic functioning of the genome has been redrafted, revealing a much more complex picture. Besides, a gene-centric conception of the organism has to be reviewed. A number of criticisms have emerged against the ENCODE project approaches, raising the question of whether non-conserved but biochemically active regions are truly functional. Thus, HGP and ENCODE projects accomplished a great map of the human genome, but the data generated still requires further in depth analysis. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:215-223, 2016.

  6. Human papillomavirus infection: knowledge, attitudes, and behaviors among lesbian, gay men, and bisexual in Italy.

    Directory of Open Access Journals (Sweden)

    Concetta P Pelullo

    Full Text Available BACKGROUND: This cross-sectional study assess knowledge, attitudes, and behavior towards the human papillomavirus (HPV and the vaccination among a random sample of 1000 lesbian, gay men, and bisexual women and men. METHODS: A face-to-face interview sought information about: socio-demographic characteristics, knowledge about HPV infection, perception of risk towards HPV infection and/or cervical, anal, and oropharyngeal cancers, perception of the benefits of a vaccination to prevent cervical, anal, and oropharyngeal cancers, sexual behaviors, health-promoting behaviors, and willingness to receive the HPV vaccine. RESULTS: Only 60.6% had heard about the HPV infection and this knowledge was significantly higher in female, in those being a member of a homosexual association, in those having had the first sexual experience at a younger age, in those having received information about the HPV infection from physicians, and in those having no need of information about HPV infection. A higher perceived risk of contracting HPV infection has been observed in those younger, lesbian and gay men, who have heard of HPV infection and knew the risk factors and its related diseases, who have received information about HPV infection from physicians, and who need information about HPV infection. Only 1.7% have undergone HPV immunization and 73.3% professed intent to obtain it in the future. The significant predictors of the willingness to receive this vaccine were belief that the vaccination is useful, perception to be at higher risk of contracting HPV infection, and perception to be at higher risk of developing cervical, anal, and oropharyngeal cancers. CONCLUSIONS: Information and interventions are strongly needed in order to overcome the lack of knowledge about HPV infection and its vaccination. Inclusion of boys in the national vaccination program and initiate a catch-up program for men who have sex with men up to 26 years may reduce their burden of HPV

  7. Human papillomavirus vaccines and cervical cancer: awareness, knowledge, and risk perception among Turkish undergraduate students.

    Science.gov (United States)

    Rathfisch, Gülay; Güngör, İlkay; Uzun, Ece; Keskin, Özlem; Tencere, Zeliha

    2015-03-01

    The aim of this study was to evaluate awareness, knowledge, and risk perception about human papillomavirus (HPV), cervical cancer, and HPV vaccines among undergraduate students in Turkey. The convenience sample of this descriptive cross-sectional study consisted of 605 undergraduate students in Istanbul University during a semester. Demographic characteristics of students, their reproductive health and lifestyle behaviors, and knowledge of HPV and HPV vaccine were questioned using self-administered forms. The overall proportion of students who had heard about HPV infection was 48.8%, while the proportion of students who had heard of the HPV vaccine was 44.5%. Forty eight percent of females and 60% of males reported never having heard of the HPV. Only 45.7% of females had knowledge about HPV as a cause of genital warts, and 58.1% correctly indicated that HPV caused cervical cancer. The majority of students in both genders (>80%) knew that the infection is primarily transmitted through sexual intercourse. Females were more concerned than males about having cervical/penile cancer associated with HPV in the future. Only 46.4% of females and 39% of males reported having heard of the HPV vaccine. The majority of the female and male students did not know who should get the HPV vaccine and when to get vaccinated. Among males, 25.8% reported that they would consider getting vaccinated (if available) and 38.4% intended to vaccinate their children. Turkish undergraduate students had a low to moderate level of knowledge regarding HPV infection and HPV vaccine. In order to increase awareness about HPV and develop positive behaviors, young people should be provided with accurate information through educational activities in the community and health care services.

  8. Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer

    Directory of Open Access Journals (Sweden)

    Nicholas C. Gomez

    2016-11-01

    Full Text Available Chromatin regulation is critical for differentiation and disease. However, features linking the chromatin environment of stem cells with disease remain largely unknown. We explored chromatin accessibility in embryonic and multipotent stem cells and unexpectedly identified widespread chromatin accessibility at repetitive elements. Integrating genomic and biochemical approaches, we demonstrate that these sites of increased accessibility are associated with well-positioned nucleosomes marked by distinct histone modifications. Differentiation is accompanied by chromatin remodeling at repetitive elements associated with altered expression of genes in relevant developmental pathways. Remarkably, we found that the chromatin environment of Ewing sarcoma, a mesenchymally derived tumor, is shared with primary mesenchymal stem cells (MSCs. Accessibility at repetitive elements in MSCs offers a permissive environment that is exploited by the critical oncogene responsible for this cancer. Our data demonstrate that stem cells harbor a unique chromatin landscape characterized by accessibility at repetitive elements, a feature associated with differentiation and oncogenesis.

  9. Consolidation effect of repeated processing of declarative knowledge in mental experiences during human sleep.

    Science.gov (United States)

    Cipolli, Carlo; Fagioli, Igino; Mazzetti, Michela; Tuozzi, Giovanni

    2006-05-15

    Sleep may positively influence declarative memory through the processing, which transforms items of declarative knowledge into contents of mental sleep experience (MSE). A prediction from this general hypothesis is that the consolidation level should be higher for the output of items repeatedly processed and transformed into identical or very similar (so-called interrelated) contents of distinct MSEs of the same night rather than for the output of items presumably processed once (that is, all other, non-interrelated contents). Two experiments examined whether and how far the frequency and long-term retention of interrelated contents depend on the repeated processing of given items rather than on the experimental procedure applied for detection of interrelated contents. This procedure entails both multiple awakenings and a verbal report of MSE after awakening. Multiple awakenings could facilitate the re-access and elaboration of some contents into the subsequent (i.e. contiguous) MSE rather than non-contiguous MSEs; verbal reports could enhance the delayed recall of interrelated contents in as much as repeatedly encoded. The first experiment showed that interrelated contents were more frequent and better retained than both non-interrelated and pseudo-interrelated (i.e. by-chance similar or identical) contents, and even more in pairs of contiguous than non-contiguous MSEs collected from the first four periods of REM sleep on each experimental night. The second experiment showed that the frequency and retention rate of interrelated contents, while higher than those of non-interrelated and pseudo-interrelated contents, were not significantly different in pairs of MSEs which were verbally or mentally recalled after awakening provoked during the first four periods of REM sleep in each experimental night. Taken together, these findings indicate that the advantage provided by repeated processing during REM sleep for the consolidation of the output of items of declarative

  10. Beyond the Letter of the Law: Accessibility, Universal Design, and Human-Centered Design in Video Tutorials

    Directory of Open Access Journals (Sweden)

    Amanda S. Clossen

    2014-05-01

    Full Text Available This article demonstrates how Universal and Human-Centered Design approaches can be applied to the process of library video tutorial creation in order to enhance accessibility. A series of questions that creators should consider in order to focus their design process is discussed. These questions break down various physical and cognitive limitations that users encounter, providing a framework for future video creation that is not dependent on specific software. By approaching accommodations more holistically, videos are created with accessibility in mind from their conception. Working toward the ideal of a video tutorial that is accessible to every user leads to the creation of more clearly worded, effective learning objects that are much more inclusive, making instructional concepts available to users of all abilities.

  11. Symbiotic intelligence: Self-organizing knowledge on distributed networks, driven by human interaction

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, N.; Joslyn, C.; Rocha, L.; Smith, S.; Kantor, M. [Los Alamos National Lab., NM (United States); Rasmussen, S. [Los Alamos National Lab., NM (United States)]|[Santa Fe Inst., NM (United States)

    1998-07-01

    This work addresses how human societies, and other diverse and distributed systems, solve collective challenges that are not approachable from the level of the individual, and how the Internet will change the way societies and organizations view problem solving. The authors apply the ideas developed in self-organizing systems to understand self-organization in informational systems. The simplest explanation as to why animals (for example, ants, wolves, and humans) are organized into societies is that these societies enhance the survival of the individuals which make up the populations. Individuals contribute to, as well as adapt to, these societies because they make life easier in one way or another, even though they may not always understand the process, either individually or collectively. Despite the lack of understanding of the how of the process, society during its existence as a species has changed significantly, from separate, small hunting tribes to a highly technological, globally integrated society. The authors combine this understanding of societal dynamics with self-organization on the Internet (the Net). The unique capability of the Net is that it combines, in a common medium, the entire human-technological system in both breadth and depth: breadth in the integration of heterogeneous systems of machines, information and people; and depth in the detailed capturing of the entire complexity of human use and creation of information. When the full diversity of societal dynamics is combined with the accuracy of communication on the Net, a phase transition is argued to occur in problem solving capability. Through conceptual examples, an experiment of collective decision making on the Net and a simulation showing the effect of noise and loss on collective decision making, the authors argue that the resulting symbiotic structure of humans and the Net will evolve as an alternative problem solving approach for groups, organizations and society. Self

  12. Symbiotic intelligence: Self-organizing knowledge on distributed networks, driven by human interaction

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, N.; Joslyn, C.; Rocha, L.; Smith, S.; Kantor, M. [Los Alamos National Lab., NM (United States); Rasmussen, S. [Los Alamos National Lab., NM (United States)]|[Santa Fe Inst., NM (United States)

    1998-07-01

    This work addresses how human societies, and other diverse and distributed systems, solve collective challenges that are not approachable from the level of the individual, and how the Internet will change the way societies and organizations view problem solving. The authors apply the ideas developed in self-organizing systems to understand self-organization in informational systems. The simplest explanation as to why animals (for example, ants, wolves, and humans) are organized into societies is that these societies enhance the survival of the individuals which make up the populations. Individuals contribute to, as well as adapt to, these societies because they make life easier in one way or another, even though they may not always understand the process, either individually or collectively. Despite the lack of understanding of the how of the process, society during its existence as a species has changed significantly, from separate, small hunting tribes to a highly technological, globally integrated society. The authors combine this understanding of societal dynamics with self-organization on the Internet (the Net). The unique capability of the Net is that it combines, in a common medium, the entire human-technological system in both breadth and depth: breadth in the integration of heterogeneous systems of machines, information and people; and depth in the detailed capturing of the entire complexity of human use and creation of information. When the full diversity of societal dynamics is combined with the accuracy of communication on the Net, a phase transition is argued to occur in problem solving capability. Through conceptual examples, an experiment of collective decision making on the Net and a simulation showing the effect of noise and loss on collective decision making, the authors argue that the resulting symbiotic structure of humans and the Net will evolve as an alternative problem solving approach for groups, organizations and society. Self

  13. Multi-Disciplinary Knowledge Synthesis for Human Health Assessment on Earth and in Space

    Science.gov (United States)

    Christakos, G.

    We discuss methodological developments in multi-disciplinary knowledge synthesis (KS) of human health assessment. A theoretical KS framework can provide the rational means for the assimilation of various information bases (general, site-specific etc.) that are relevant to the life system of interest. KS-based techniques produce a realistic representation of the system, provide a rigorous assessment of the uncertainty sources, and generate informative health state predictions across space-time. The underlying epistemic cognition methodology is based on teleologic criteria and stochastic logic principles. The mathematics of KS involves a powerful and versatile spatiotemporal random field model that accounts rigorously for the uncertainty features of the life system and imposes no restriction on the shape of the probability distributions or the form of the predictors. KS theory is instrumental in understanding natural heterogeneities, assessing crucial human exposure correlations and laws of physical change, and explaining toxicokinetic mechanisms and dependencies in a spatiotemporal life system domain. It is hoped that a better understanding of KS fundamentals would generate multi-disciplinary models that are useful for the maintenance of human health on Earth and in Space.

  14. Human-Nature Relationship in Mediterranean Streams: Integrating Different Types of Knowledge to Improve Water Management

    Directory of Open Access Journals (Sweden)

    Carla Gonzalez

    2009-12-01

    Full Text Available The social and ecological systems of Mediterranean streams are intrinsically linked as a result of long human occupation. In this region, these links vary greatly across small distances due to geomorphology, resulting in great diversity across space, which poses particular challenges for understanding and managing these systems. This demands (i interdisciplinary integration of knowledge that focuses on the social-ecological interactions, while according due consideration to the whole; and also (ii transdisciplinary integration, integrating lay and expert knowledge to understand local specificities. To address these needs - a focus on interactions and local knowledge - the research presented here studies the human-nature relationship in Mediterranean streams. Its main objective is to improve understanding of Mediterranean streams, but it also provides practical inputs to enhance local-level management. The study adopts an applied approach from the perspective of natural resources management. A case study was developed conducting field work on streams within the Natura 2000 site of Monfurado, Portugal - a mainly privately owned area with conflicting land uses between conservation and farming. Rivers and streams in Portugal are considered to be in very bad condition, particularly with regard to water quality. The experimental design was based, from a critical realism perspective of inter- and trans-disciplinarity, on the complementarities between methodologies from (i the social sciences: value survey and analysis of discourse; and (ii the natural sciences: biomonitoring and integrity biotic indexes. Results characterized the connected systems from both ecological and social points of view. They also characterized the relationship between both dimensions. We concluded that well-established riparian vegetation cover of streams is a key structural element of the human-nature relationship in the Mediterranean streams of Monfurado at several levels

  15. The Role of a Human Factor and Psychological Contract in Managing the Knowledge in Conditions of Globalization

    Directory of Open Access Journals (Sweden)

    Joanna Rębisz

    2008-07-01

    Full Text Available The modern business world is characterized by dynamic, changing markets and continuous technological advance. This article focuses on an issue related to a definition of the meaning of a man and his location in an organization that works in conditions of globalization. Certainly, the meaning of human as the source of knowledge in the development of organization is not a new subject. Knowledge is intrinsically linked to people and enables them to act. Modern organizations base their theory on the knowledge they can exploit to improve the competence of the employee, his loyalty and commitment to the company which aims at the competitive predominance. The identification of knowledge is necessary for the effective implementation of knowledge management system. Above all, presented theoretical analysis pinpoints mainly on discussing a mans role and psychological contract in managing the knowledge.

  16. The Hybrid Design: Integrating the Human and Technical Components of Just-In-Time Knowledge Management Systems

    Directory of Open Access Journals (Sweden)

    Nabie Y. Conteh

    2011-06-01

    Full Text Available This paper explores the right balance of human and technical resources in the design of Just-in-Time knowledge delivery. It also examines and analyzes the case study: “Teltech: The business of Knowledge Management” by Davenport. It further attempts to depict the characteristics of the hybrid. The paper describes how the hybrid can be applied to Just-In-Time knowledge delivery. It also seeks to analyze and explore its interplay with knowledge splits with a view to designing Just-In- Time Knowledge Management. These include: “tacit versus explicit knowledge”, “in-process” versus “after action” documentation, “process-centered versus product-centered approach”, “knowledge versus information” and the “culture of sharing versus hoarding.”

  17. An Empirical Research on the Correlation between Human Capital and Career Success of Knowledge Workers in Enterprise

    Science.gov (United States)

    Guo, Wenchen; Xiao, Hongjun; Yang, Xi

    Human capital plays an important part in employability of knowledge workers, also it is the important intangible assets of company. This paper explores the correlation between human capital and career success of knowledge workers. Based on literature retrieval, we identified measuring tool of career success and modified further; measuring human capital with self-developed scale of high reliability and validity. After exploratory factor analysis, we suggest that human capital contents four dimensions, including education, work experience, learning ability and training; career success contents three dimensions, including perceived internal competitiveness of organization, perceived external competitiveness of organization and career satisfaction. The result of empirical analysis indicates that there is a positive correlation between human capital and career success, and human capital is an excellent predictor of career success beyond demographics variables.

  18. Access to treatment in developing countries: a global issue of equity and human rights.

    Science.gov (United States)

    Thomas, J

    1998-04-01

    People are highly optimistic about the possibility of recent developments in combination antiretroviral therapy for HIV/AIDS to effectively treat people with HIV/AIDS, thereby prolonging their survival and improving the quality of life. Access to advanced retroviral therapy for HIV/AIDS in developing countries, however, is rarely discussed as feasible. Many people even believe that access for all to optimum AIDS care is an utopian ideal not worth pursuing. Imaginative, radical steps together with political will could, however, help to broaden access to advanced therapy for people with HIV/AIDS. A global AIDS-related biomedical technology transfer initiative is needed. Such an initiative should foster a partnership between governments, industry, and international organizations based upon a maximalist perspective of the ethics of access to treatment, global equity considerations, and a global perspective upon individual and community rights. Challenges, a global AIDS trade protocol, and political will are discussed.

  19. Knowledge and Beliefs Regarding Human Papillomavirus Among College Students at a Minority-Serving Institution

    Science.gov (United States)

    Schmotzer, Geri; Reding, Kerryn

    2017-01-01

    Background Cervical cancer is a leading cause of death in U.S. women, with Hispanic women at higher risk of mortality than non-Hispanic white women. While the human papillomavirus (HPV) vaccine represents substantial progress towards cervical cancer prevention, little is currently known about Hispanic student’s beliefs regarding the HPV vaccine. Objective To assess the knowledge, attitudes, behaviors, and beliefs of college students in the U.S.-Mexico border region following the release of the HPV vaccine for both males and females. Methods This survey was conducted using a convenience sample where participants were recruited from pre-nursing and nursing courses. The self-administered questionnaire ascertained HPV vaccination status, and knowledge and beliefs regarding the HPV vaccine. Results 202 male and female students responded. 28.9% of respondents reported having received the HPV vaccine. Of the non-vaccinated students under age 27, 27.3% Hispanic students reported an intention to receive the vaccine. Misinformation about HPV was common and among non-Hispanic white students was associated with intention to get vaccinated. Conclusions We found a relatively small proportion of unvaccinated Hispanic and non-Hispanic nursing students intending to be vaccinated for HPV. Findings indicate an intervention to increase vaccination rates among college-aged students may not be as straightforward as increasing knowledge of HPV. Implications for Practice Nurses are in a unique position to educate and recommend HPV to underserved patients. Thus, educating nursing students regarding HPV and the associated cancers is paramount if we are to encourage ethnic minorities to receive the HPV vaccine. PMID:23813323

  20. Human Papilloma Virus and HPV vaccine knowledge among Mustafa Kemal University Medical Students

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    Raziye Keskin Kurt

    2014-02-01

    Full Text Available Background: Human papilloma virus (HPV is regarded as the main cause in the etiology of cervical cancer. The purpose of our study is to assess the knowledge of medical students about HPV vaccine and to evaluate their opinion on this subject.   Material and Method: The study population consisted of 488 medical students. The survey was composed of questions intended   to obtain information about transmission route of HPV, types of HPV, role of HPV in cervical cancer, whether HPV is treatable or not, which types of HPV the HPV vaccine prevents, the age groups HPV vaccine is administered, the opinions on HPV vaccine and sufficiency of public health, whether female students have underwent vaccination and if not what their drawbacks are.   Results: Mean age of the students participating in the study was 21±4 and 58 % of the patients were female. Out of 448 medical students, 60% of them did not know that HPV was a sexually transmitted disease. Only 55% students knew about the association of HPV with cervical cancer and 52% participants stated that HPV vaccine could not be preventive against cervical cancer. None of female students had been immunized and 67% of female students did not consider getting immunized. Among those who did not consider getting immunized, 70% said they had worries about the safety of the vaccine. Conclusion: Our study results revealed that the knowledge of medical students about HPV is satisfactory, however their knowledge about HPV vaccine, immunization status and desire to be immunized were little.

  1. Limits of responsiveness concerning human-readable knowledge bases: an operational analysis

    CERN Document Server

    Pentzaropoulos, G C

    2010-01-01

    Introduction. The purpose of this work is the evaluation of responsiveness when remote users communicate with a human-readable knowledge base (KB). Responsiveness [R(s)] is considered here as a measure of service quality. Method. The preferred method is operational analysis, a variation of classical stochastic theory, which allows for the study of user-system interaction with minimal computational effort. Analysis. The analysis is based on well-known performance metrics, such as service ability, elapsed time, and throughput: from these metrics estimates of R(s) are derived analytically. Results. Critical points indicating congestion are obtained: these are limits on the number of admissible requests and the number of connected users. Also obtained is a sufficient condition for achieving flow balance between the KB host and the request-relaying servers. Conclusions. When R(s) is within normal limits, users should appreciate the benefits from using the services offered by their KB host. When bottlenecks are for...

  2. Linking an agency strategic review to increase knowledge management: San Francisco County Human Service Agency.

    Science.gov (United States)

    Harrison, Lindsay

    2012-01-01

    Led by the agency director, the agency engaged in a Strategic Review, based on a comprehensive assessment of agency performance that identified strategies to improve organizational effectiveness through increased data-informed practice and knowledge management. The Strategic Review gathered information on staff perceptions, perceptions of external stakeholders, changing citywide and neighborhood demographics, policy mandates, and budget and workload issues. The need for the review was based upon multiple, substantial changes not addressed in the 2000 Strategic Plan, including the 2004 merger of the Department of Human Services and the Department of Aging and Adult Services, changes among the executive management team, transitions among key political entities, new policy mandates and changing budget allocations. This case study describes the Strategic Review process and content, summarizing key challenges and lessons related to addressing workload demands, fostering positive staff attitudes, balancing internal and external information needs, and integrating data use and planning processes across the agency. Copyright © Taylor & Francis Group, LLC

  3. Knowledge and attitudes about Human Papilloma Virus (HPV) vaccination and cervical cancer screening among women in rural Uganda (POSTPRINT)

    Science.gov (United States)

    2016-01-01

    about Human Papilloma Virus (HPV) vaccination and cervical cancer screening among women in rural Uganda NKONWA INNOCENT H 1,2,3* , MICHAEL J...Human Papilloma virus (HPV) strains 16 and 18. While cervical cancer is widely understood as a fatal disease, knowledge and awareness of cervical...capture assay of self – collected virginal swabs in rural Uganda for detection of human papilloma virus . J Infect Disease, 1999 1999.180; p. 1316.1319. 19

  4. Human papillomavirus and cancer prevention: gaps in knowledge and prospects for research, policy, and advocacy.

    Science.gov (United States)

    Franco, Eduardo L; de Sanjosé, Silvia; Broker, Thomas R; Stanley, Margaret A; Chevarie-Davis, Myriam; Isidean, Sandra D; Schiffman, Mark

    2012-11-20

    The recognition that human papillomavirus (HPV) infection is the central, necessary cause of cervical cancer paved the way to new fronts of prevention via improved screening methods and HPV vaccination. Much has been learned in all fronts, from the molecular basis of our understanding of how HPV causes disease to the health economics of preventive strategies at the individual and population levels. Progress in other areas of cancer control has yet to show the same multi- and trans-disciplinary gains seen in research on HPV-associated malignancies, which is one of the unequivocal success stories in disease prevention. Yet, as an embarrassment of riches, much more research is needed to fill the gaps in knowledge that remain before we are able to reap the benefits from the knowledge translation from all fronts. Public health research on setting-specific implementation of HPV-based preventive strategies and more concerted advocacy to counter barriers facing the adoption of these strategies are likely to yield major dividends in reducing the burden of HPV-associated diseases. This article forms part of a special supplement entitled "Comprehensive Control of HPV Infections and Related Diseases" Vaccine Volume 30, Supplement 5, 2012.

  5. Knowledge of Greek adolescents on human papilloma virus (HPV) and vaccination

    Science.gov (United States)

    Vaidakis, Dennis; Moustaki, Irini; Zervas, Ioannis; Barbouni, Anastasia; Merakou, Kyriaki; Chrysi, Maria S.; Creatsa, George; Panoskaltsis, Theodoros

    2017-01-01

    Abstract The aim of the present study was to identify the sexual behavior, attitudes, beliefs, and knowledge on sexually transmitted infections (STIs) focused on human papilloma virus (HPV) in the Greek adolescent population. The participants were 4547 adolescents, a representative sample for Greek territory with a mean age of 17 years. After written permission from Greek ministry of education each student completed a questionnaire with 36 questions. The fields covered were demographic characteristics, sexual life data, and basic knowledge on HPV. In the present study, 43% and 75% of the participants knew about HPV or cervical cancer, while more than 6 out of 10 did not know the association between the 2. More than 60% of the participants could not answer correctly neither about HPV infection and cervical cancer frequency in sexually active women, nor about protection methods against HPV and cervical cancer. This study shows that the low vaccination coverage of the Greek population may be due to lack of information and awareness of the adolescents and their parents. It is our duty to increase our efforts in order to better educate the population and vaccinate the population as early as possible in their reproductive years. PMID:28072683

  6. Human resources management and organizational development as a basis for the knowledge management

    Directory of Open Access Journals (Sweden)

    Mária Antošová

    2010-02-01

    Full Text Available Effective usage of people’s knowledge, abilities and creativity of people is becoming the key for successful performancein competitive environment of the global economy. Creation of a new discipline – the knowledge management is a reaction to this trend.It includes all progress trends of the recent years and furthermore, it tries to develop a systematic method how to identify, obtain,maintain, and use the intellectual capital. Nowadays, nobody doubts that success of every company on the global market in great extent,depends on how fast it can adjust to quick changes of the business environment. This is also one of the reasons why human capitalis becoming a crucial and more valuable factor. Currently, during the era of globalization, the changes are extremely fast thereforeit is necessary that companies to reassess instruments and procedures that have been used so far. A proper way is to activate the wholesystem, think about organizational development and through that change acquire such a system that will be suitable for rapid changein business.

  7. Access to physical health care for people with serious mental illness: a nursing perspective and a human rights perspective-common ground?

    Science.gov (United States)

    Nankivell, Janette; Platania-Phung, Chris; Happell, Brenda; Scott, David

    2013-06-01

    Relative to the general population, people with serious mental illness (SMI) experience elevated risks of physical disease and illness and live shorter lives. A human rights perspective argues that people with serious mental illness have a right to equal access to physical health care. Nurses in mental health services can contribute to improving the availability and accessibility of physical health care. This study, involving focus group interviews with nurses in a large regional and rural mental health care district of Queensland, Australia, revealed significant problems in access to physical health care for service users. The current article reports on our exploratory analysis of nurses' views and perceptions to identify (1) orientation of nurses to human rights, and (2) access of consumers with SMI to general practitioner services. It was rare for nurses to raise the topic of human rights, and when raised, it was not as a strategy for improving access to physical health care services that they felt consumers with SMI greatly needed. Two main themes were identified as causes of poor access: clinical barriers to physical care and attitudinal barriers to physical care. In light of these results, the authors explore a human rights perspective on access and how this provides an inclusive lobbying umbrella under which nurses and other groups can pursue access to physical health services that are adequate, accessible, and non-discriminatory. The article then discusses the implications for these findings for the value of human rights as a perspective and means of increasing physical health of people with SMI.

  8. Hepatitis C Virus Treatment Access Among Human Immunodeficiency Virus and Hepatitis C Virus (HCV)-Coinfected People Who Inject Drugs in Guangzhou, China: Implications for HCV Treatment Expansion.

    Science.gov (United States)

    Chu, Carissa E; Wu, Feng; He, Xi; Zhou, Kali; Cheng, Yu; Cai, Weiping; Geng, Elvin; Volberding, Paul; Tucker, Joseph D

    2016-04-01

    Background.  Hepatitis C virus (HCV) treatment access among human immunodeficiency virus (HIV)/HCV-coinfected people who inject drugs is poor, despite a high burden of disease in this population. Understanding barriers and facilitators to HCV treatment uptake is critical to the implementation of new direct-acting antivirals. Methods.  We conducted in-depth interviews with patients, physicians, and social workers at an HIV treatment facility and methadone maintenance treatment centers in Guangzhou, China to identify barriers and facilitators to HCV treatment. We included patients who were in various stages of HCV treatment and those who were not treated. We used standard qualitative methods and organized data into themes. Results.  Interview data from 29 patients, 8 physicians, and 3 social workers were analyzed. Facilitators and barriers were organized according to a modified Consolidated Framework for Implementation Research schematic. Facilitators included patient trust in physicians, hope for a cure, peer networks, and social support. Barriers included ongoing drug use, low HCV disease knowledge, fragmented reimbursement systems, HIV exceptionalism, and stigma. Conclusions.  Expanding existing harm reduction programs, HIV treatment programs, and social services may facilitate scale-up of direct-acting antivirals globally. Improving integration of ancillary social and mental health services within existing HIV care systems may facilitate HCV treatment access.

  9. Hepatitis C Virus Treatment Access Among Human Immunodeficiency Virus and Hepatitis C Virus (HCV)-Coinfected People Who Inject Drugs in Guangzhou, China: Implications for HCV Treatment Expansion

    Science.gov (United States)

    Chu, Carissa E.; Wu, Feng; He, Xi; Zhou, Kali; Cheng, Yu; Cai, Weiping; Geng, Elvin; Volberding, Paul; Tucker, Joseph D.

    2016-01-01

    Background. Hepatitis C virus (HCV) treatment access among human immunodeficiency virus (HIV)/HCV-coinfected people who inject drugs is poor, despite a high burden of disease in this population. Understanding barriers and facilitators to HCV treatment uptake is critical to the implementation of new direct-acting antivirals. Methods. We conducted in-depth interviews with patients, physicians, and social workers at an HIV treatment facility and methadone maintenance treatment centers in Guangzhou, China to identify barriers and facilitators to HCV treatment. We included patients who were in various stages of HCV treatment and those who were not treated. We used standard qualitative methods and organized data into themes. Results. Interview data from 29 patients, 8 physicians, and 3 social workers were analyzed. Facilitators and barriers were organized according to a modified Consolidated Framework for Implementation Research schematic. Facilitators included patient trust in physicians, hope for a cure, peer networks, and social support. Barriers included ongoing drug use, low HCV disease knowledge, fragmented reimbursement systems, HIV exceptionalism, and stigma. Conclusions. Expanding existing harm reduction programs, HIV treatment programs, and social services may facilitate scale-up of direct-acting antivirals globally. Improving integration of ancillary social and mental health services within existing HIV care systems may facilitate HCV treatment access. PMID:27419150

  10. An approach to integrate the human vision psychology and perception knowledge into image enhancement

    Science.gov (United States)

    Wang, Hui; Huang, Xifeng; Ping, Jiang

    2009-07-01

    Image enhancement is very important image preprocessing technology especially when the image is captured in the poor imaging condition or dealing with the high bits image. The benefactor of image enhancement either may be a human observer or a computer vision process performing some kind of higher-level image analysis, such as target detection or scene understanding. One of the main objects of the image enhancement is getting a high dynamic range image and a high contrast degree image for human perception or interpretation. So, it is very necessary to integrate either empirical or statistical human vision psychology and perception knowledge into image enhancement. The human vision psychology and perception claims that humans' perception and response to the intensity fluctuation δu of visual signals are weighted by the background stimulus u, instead of being plainly uniform. There are three main laws: Weber's law, Weber- Fechner's law and Stevens's Law that describe this phenomenon in the psychology and psychophysics. This paper will integrate these three laws of the human vision psychology and perception into a very popular image enhancement algorithm named Adaptive Plateau Equalization (APE). The experiments were done on the high bits star image captured in night scene and the infrared-red image both the static image and the video stream. For the jitter problem in the video stream, this algorithm reduces this problem using the difference between the current frame's plateau value and the previous frame's plateau value to correct the current frame's plateau value. Considering the random noise impacts, the pixel value mapping process is not only depending on the current pixel but the pixels in the window surround the current pixel. The window size is usually 3×3. The process results of this improved algorithms is evaluated by the entropy analysis and visual perception analysis. The experiments' result showed the improved APE algorithms improved the quality of the

  11. Racial and Ethnic Group Knowledge, Perceptions and Behaviors about Human Papillomavirus, Human Papillomavirus Vaccination, and Cervical Cancer among Adolescent Females.

    Science.gov (United States)

    Bond, Sharon M; Cartmell, Kathleen B; Lopez, Cristina M; Ford, Marvella E; Brandt, Heather M; Gore, Elena I; Zapka, Jane G; Alberg, Anthony J

    2016-10-01

    Human papillomavirus (HPV) vaccines provide an opportunity to greatly reduce the burden of cervical cancer. Although there has been improvement in uptake, there are notable ethnic/racial disparities. This qualitative study was conducted to better understand factors related to vaccine uptake among female adolescents from 3 racial/ethnic groups: African American (AA), Hispanic, and Caucasian. Findings can inform the development of optimal messages and strategies for clinical and population-based interventions. This mixed-methods descriptive study included completion of a brief structured survey and focus group discussion. Six focus groups were conducted with female adolescents, 2 each in the AA, Hispanic, and Caucasian groups. Brief structured survey questions and the focus group protocol addressed knowledge, perceptions, and behaviors related to HPV, HPV vaccination, and cervical cancer. Participants were 60 female adolescents (ages 13-19, mean age = 16.6 years) recruited from high schools, public health clinics, and churches. Themes across questions were remarkably similar among AA, Hispanic, and Caucasian participants. Each group had high awareness of the terms HPV, HPV vaccination, and cervical cancer, but with little in-depth knowledge about these topics. There was a high acceptance of HPV vaccination. Misperceptions about optimal cervical cancer prevention strategies such as simply knowing one's partner and good hygiene were most common among Hispanic adolescents. Awareness about Pap testing was most common among Caucasian adolescents. Predominantly uniform perceptions of HPV vaccines across racial/ethnic groups suggest a "one size fits all" approach will likely have greater reach with cervical cancer prevention messaging than culturally tailored interventions. Copyright © 2016 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  12. "The Human Condition" as social ontology: Hannah Arendt on society, action and knowledge.

    Science.gov (United States)

    Walsh, Philip

    2011-01-01

    Hannah Arendt is widely regarded as a political theorist who sought to rescue politics from "society," and political theory from the social sciences. This conventional view has had the effect of distracting attention from many of Arendt's most important insights concerning the constitution of "society" and the significance of the social sciences. In this article, I argue that Hannah Arendt's distinctions between labor, work, and action, as these are discussed in "The Human Condition" and elsewhere, are best understood as a set of claims about the fundamental structures of human societies. Understanding Arendt in this way introduces interesting parallels between Arendt's work and both classical and contemporary sociology. From this I draw a number of conclusions concerning Arendt's conception of "society," and extend these insights into two contemporary debates within contemporary theoretical sociology: the need for a differentiated ontology of the social world, and the changing role that novel forms of knowledge play in contemporary society as major sources of social change and order.

  13. Knowledge and attitudes of university students and their mothers regarding the Human Papilloma Virus

    Directory of Open Access Journals (Sweden)

    Evangelia Tsipra

    2015-04-01

    Full Text Available Introduction: Human Papilloma Virus (HPV is one of the most common causes of sexually transmitted diseases in both men and women worldwide. Aim: The investigation of the knowledge of university students and their mothers about the HPV, the ways of transmission, prevention and vaccination. Material and Method: The studied population consisted of 605 students from Technological Educational Institute of Athens and 50 mothers which filled two different questionnaires with closed-ended questions. Data was statistically processed with Microsoft Excel and SPSS ver.20. Results: Although, a large percentage (84.5% of the questioned students were sexually active, the majority of them (67.7% had never done the human papilloma virus vaccine and they didn’t intended to do it (87.9%. Although questioned mothers were aware that both girls and boys should be vaccinated against HPV infection (83.7%, only 71.4% of them had vaccinated their children, because of their fear of possible side effects (p0.05. Conclusion: Although students and mothers were aware of the HPV and its prevention, they were not familiar with the safety and the effectiveness of the vaccine, maybe because more students had been informed about the HPV from their family mostly than their gynecologist.

  14. The Knowledge Society: A Sustainability Paradigm

    Directory of Open Access Journals (Sweden)

    Naim Hamdija Afgan

    2010-10-01

    Full Text Available This paper defines the knowledge society as a human structured organisation based on contemporary developed knowledge and representing new quality of life support systems. It implies the need for a full understanding of distribution of knowledge, access to information and the capability to transfer information into a knowledge. The understanding of knowledge is the central challenge when defining a knowledge society. From our present perception of knowledge society, it is of interest to emphasize the role of the knowledge society in future development of human society. The life support systems are essential pillars of human society development. In this respect knowledge society represents a new paradigm for future development and it is strongly correlated to sustainable development. For this reason the sustainability paradigm of knowledge society is a potential frame for human society development leading to social cohesion, economic competitiveness and stability, use of resources and economic development, safeguarding biodiversity and the ecosystem.In order to verify the mutual relation between knowledge society and sustainability, we have to introduce the difference between these two terms. The knowledge society is based on the agglomeration of eco-knowledge, env-knowledge and soc-knowledge, it may be evaluated as the complex knowledge of quality of life support systems. We have to introduce metrics which will allow us to present knowledge as the paradigm of the number of indicators for verifying progress made.Sustainability metrics are designed to consolidate measures of economic, environmental and social performance of any system. It can be understood as a pattern for evaluation of the available knowledge about systems and their performance. In particular the decision-making process for the selection of the system under consideration must be based on the available knowledge. The link between knowledge and sustainability makes it possible for

  15. Italian women and HPV prevention. Knowledge, fears, uncertainty on Human Papillomavirus and the relative vaccination: dual research approach

    Directory of Open Access Journals (Sweden)

    Concetta M. Vaccaro

    2012-03-01

    Full Text Available

    Abstract:
    Background: the main purpose of this study was to identify and describe knowledge, beliefs and atti- tudes towards Human Papillomavirus (HPV infection and HPV vaccination among Italian women aged between 18 and 55. MeTHods: 6 Focus groups, in each of which 8 women took part, held in 6 different locations and a survey on a representative sample of 3 500 Italian women aged between 18 and 55, with oversizing for three regions (Lombardy, Latium, sicily. The survey was conducted by telephone using the caTI (computer assisted Telephone Interview technique, in september 2011, adopting a structured questionnaire. data were codified and statistical analysis was computed using sPss software.
    Results: italian women have only a partial, even superficial, knowledge of pathologies associated with HPV, and also their information on the purpose of prevention activity, in which they choose to partici- pate, is more generic than one might expect. The weakness of the information framework is partly due to the fact that the main source of information is the mass media, mainly the press and television, and to a lesser extent the Internet, and that information is random and fragmented.
    Information about HPV and the possibility of vaccination often overlap, and it is the specific occasion of contact with the asL (local health authority vaccine services, providing information to youngsters that are the target of the free campaign, that is central in gaining access to information about the virus and vaccination, especially for the mothers of adolescent daughters. The vaccine campaign not only plays a key role in providing information about HPV and about the vaccination, but also ends up by influencing the notions and beliefs that Italian women hold about this vaccination.
    Conslusions: only a small portion of the female population, directly involved in the free

  16. Parallel retrieval and application to conceptual knowledge

    Energy Technology Data Exchange (ETDEWEB)

    Dolan, C.P.; Dyer, M.

    1987-01-01

    Humans have the ability to recognize and reason about a wide variety of social behaviors in their fellows: deception, professional relationships, goal seeking, argumentation, etc. Much of this ability is centered around our ability to manipulate conceptual knowledge. There have been a number of computer programs which have demonstrated the capability to use conceptual knowledge as modeled by data structures in symbolic languages. Three fundamental problems are knowledge representation, knowledge access (i.e. which knowledge structures to activate) and knowledge application to specific instances (i.e. which symbols or roles in the knowledge structures are bound to which objects in the current situation). Although results have been enlightening as to processes underlying the use of conceptual knowledge, they have all been based on serial examination of symbolic data structures. This serial approach is unacceptable as a complete model of human performance. This paper presents a distributed connectionist model which retrieves and applies conceptual structures in parallel.

  17. Double-edged sword of interdisciplinary knowledge flow from hard sciences to humanities and social sciences: Evidence from China.

    Science.gov (United States)

    Liu, Meijun; Shi, Dongbo; Li, Jiang

    2017-01-01

    Humanities and Social Sciences (HSS) increasingly absorb knowledge from Hard Sciences, i.e., Science, Technology, Agriculture and Medicine (STAM), as testified by a growing number of citations. However, whether citing more Hard Sciences brings more citations to HSS remains to be investigated. Based on China's HSS articles indexed by the Web of Science during 1998-2014, this paper estimated two-way fixed effects negative binomial models, with journal effects and year effects. Findings include: (1) An inverse U-shaped curve was observed between the percentage of STAM references to the HSS articles and the number of citations they received; (2) STAM contributed increasing knowledge to China's HSS, while Science and Technology knowledge contributed more citations to HSS articles. It is recommended that research policy should be adjusted to encourage HSS researchers to adequately integrate STAM knowledge when conducting interdisciplinary research, as over-cited STAM knowledge may jeopardize the readability of HSS articles.

  18. Eye Care Quality and Accessibility Improvement in the Community (EQUALITY: impact of an eye health education program on patient knowledge about glaucoma and attitudes about eye care

    Directory of Open Access Journals (Sweden)

    Rhodes LA

    2016-05-01

    Full Text Available Lindsay A Rhodes,1 Carrie E Huisingh,1 Gerald McGwin Jr,1,2 Stephen T Mennemeyer,3 Mary Bregantini,4 Nita Patel,4 Jinan Saaddine,5 John E Crews,5 Christopher A Girkin,1 Cynthia Owsley11Department of Ophthalmology, School of Medicine, 2Department of Epidemiology, 3Department of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 4Prevent Blindness, Chicago, IL, USA; 5Vision Health Initiative, Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USAPurpose: To assess the impact of the education program of the Eye Care Quality and Accessibility Improvement in the Community (EQUALITY telemedicine program on at-risk patients’ knowledge about glaucoma and attitudes about eye care as well as to assess patient satisfaction with EQUALITY.Patients and methods: New or existing patients presenting for a comprehensive eye exam (CEE at one of two retail-based primary eye clinics were enrolled based on ≥1 of the following at-risk criteria for glaucoma: African Americans ≥40 years of age, Whites ≥50 years of age, diabetes, family history of glaucoma, and/or preexisting diagnosis of glaucoma. A total of 651 patients were enrolled. A questionnaire was administered prior to the patients’ CEE and prior to the patients receiving any of the evidence-based eye health education program; a follow-up questionnaire was administered 2–4 weeks later by phone. Baseline and follow-up patient responses regarding knowledge about glaucoma and attitudes about eye care were compared using McNemar’s test. Logistic regression models were used to assess the association of patient-level characteristics with improvement in knowledge and attitudes. Overall patient satisfaction was summarized.Results: At follow-up, all patient responses in the knowledge and attitude domains significantly improved from baseline (P≤0.01 for all questions. Those who were unemployed (odds

  19. A human rights view on access to controlled substances for medical purposes under the international drug control framework.

    Science.gov (United States)

    Gispen, Marie Elske C

    2013-11-05

    The world is confronted with a major public health deficit caused by poor access to controlled essential medicines under the international drug control framework. This is affecting millions of patients on a daily basis and resulting in numerous human rights violations. The present review contextualises this deficit from a human rights perspective. Drug control efforts are informed by a twofold objective stemming from the double nature of scheduled substances: free access for medical purposes should be ensured, though non-medical use of substances such as opium should be restricted. The international drug control framework is, in theory, based on this twofold notion, however at the level of interpretation, monitoring, and implementation, a one-sided emphasis is demonstrated. By tracing a parallel between the obligations of states under the international drug control framework and those that derive from human rights law, the review shows that the two systems seem incoherent and conflicting in nature and flags the importance of cross-disciplinary research into drug control and human rights.

  20. Ontological modelling of knowledge management for human-machine integrated design of ultra-precision grinding machine

    Science.gov (United States)

    Hong, Haibo; Yin, Yuehong; Chen, Xing

    2016-11-01

    Despite the rapid development of computer science and information technology, an efficient human-machine integrated enterprise information system for designing complex mechatronic products is still not fully accomplished, partly because of the inharmonious communication among collaborators. Therefore, one challenge in human-machine integration is how to establish an appropriate knowledge management (KM) model to support integration and sharing of heterogeneous product knowledge. Aiming at the diversity of design knowledge, this article proposes an ontology-based model to reach an unambiguous and normative representation of knowledge. First, an ontology-based human-machine integrated design framework is described, then corresponding ontologies and sub-ontologies are established according to different purposes and scopes. Second, a similarity calculation-based ontology integration method composed of ontology mapping and ontology merging is introduced. The ontology searching-based knowledge sharing method is then developed. Finally, a case of human-machine integrated design of a large ultra-precision grinding machine is used to demonstrate the effectiveness of the method.

  1. Human papillomavirus infection and vaccination: Knowledge and attitudes among young males in Italy

    Science.gov (United States)

    Napolitano, Francesco; Napolitano, Paola; Liguori, Giorgio; Angelillo, Italo Francesco

    2016-01-01

    ABSTRACT This study assessed knowledge and attitudes about Human papillomavirus (HPV) and the relative vaccination and their determinants in a sample of young males. The survey was conducted between January and April 2015 among a sample of 1000 males aged between 14–24 y in the geographic area of Naples and Caserta, Italy. The 54.9% of the participants reported of having heard about the HPV infection. Those who were aware about the availability of the vaccine, who reported the first vaginal sexual encounter before the 18 y and at least at 18 y compared to those who had not had a complete sexual intercourse, who had undergone a health checkup in the last year, and who had received information about the HPV vaccine by physicians had a significant higher knowledge about the HPV infection. The 58.2% reported that they would be willing to receive the HPV vaccine. Those younger, who reported the first vaginal sexual encounter at least at 18 y, who agreed that male should receive the vaccine, who knew that both males and females can acquire the infection, and who agreed that the vaccine is an important preventive intervention, expressed more positive attitude toward willingness to receive the vaccine. More information about the HPV vaccine were required by those who agreed that the vaccine is an important preventive intervention, who reported the first vaginal sexual encounter at least at 18 y, who have had only one partner in the last year compared to students who had no partner, and who had received information about the vaccine by physicians. This study highlights a need for improved education of young males of the HPV infection and the associated diseases and about the benefit of the vaccination. PMID:27070042

  2. Simplified data access on human skeletal muscle transcriptome responses to differentiated exercise

    DEFF Research Database (Denmark)

    Vissing, Kristian; Schjerling, Peter

    2014-01-01

    to allow for easy access and interpretation of our data. We provide a simple-to-use spread sheet containing transcriptome data allowing other investigators to easily see how mRNA of their gene(s) of interest behave in skeletal muscle following exercise, both endurance, resistance and non...

  3. Human Services for Low-Income and At-Risk LGBT Populations: The Knowledge Base and Research Needs (Brief)

    OpenAIRE

    Andrew Burwick; Gary Gates; Scott Baumgartner; Daniel Friend

    2014-01-01

    This brief summarizes the current knowledge base and identifies key areas for future research related to human services for lesbian, gay, bisexual, and transgender (LGBT) populations. It focuses on three types of services funded by the Administration for Children and Families in the U.S. Department of Health and Human Services: (1) income support and self-sufficiency programs; (2) child welfare programs; and (3) programs for youth, especially services for runaway and homeless youth and sexual...

  4. Methodology and Results of the Near-Earth Object (NEO) Human Space Flight (HSF) Accessible Targets Study (NHATS)

    Science.gov (United States)

    Barbee, Brent; Mink, Ronald; Adamo, Daniel

    2011-01-01

    Near-Earth Asteroids (NEAs) have been identified by the current administration as potential destinations for human explorers during the mid-2020s. While the close proximity of these objects' orbits to Earth's orbit creates a risk of highly damaging or catastrophic impacts, it also makes some of these objects particularly accessible to spacecraft departing Earth, and this presents unique opportunities for solar system science and humanity's first ventures beyond cislunar space. Planning such ambitious missions first requires the selection of potentially accessible targets from the growing population of nearly 7,800 NEAs. To accomplish this, NASA is conducting the Near-Earth Object (NEO) Human Space Flight (HSF) Accessible Targets Study (NHATS). Phase I of the NHATS was executed during September of 2010, and Phase II was completed by early March of 2011. The study is ongoing because previously undetected NEAs are being discovered constantly, which has motivated an effort to automate the analysis algorithms in order to provide continuous monitoring of NEA accessibility. The NHATS analysis process consists of a trajectory filter and a minimum maximum estimated size criterion. The trajectory filter employs the method of embedded trajectory grids to compute all possible ballistic round-trip mission trajectories to every NEA in the Jet Propulsion Laboratory (JPL) Small-Body Database (SBDB) and stores all solutions that satisfy the trajectory filter criteria. An NEA must offer at least one qualifying trajectory solution to pass the trajectory filter. The Phase II NHATS filter criteria were purposely chosen to be highly inclusive, requiring Earth departure date between January 1st, 2015 and December 31st, 2040, total round-trip flight time = 8 days, Earth departure C(sub 3) energy = 30 m. This corresponds to an absolute magnitude H = 30 m. The distributions of osculating heliocentric orbital semi-major axis (a), eccentricity (e), and inclination (i), for those 590 NEAs are

  5. Access and use of human tissues from the developing world: ethical challenges and a way forward using a tissue trust.

    Science.gov (United States)

    Emerson, Claudia I; Singer, Peter A; Upshur, Ross E G

    2011-01-25

    Scientists engaged in global health research are increasingly faced with barriers to access and use of human tissues from the developing world communities where much of their research is targeted. In part, the problem can be traced to distrust of researchers from affluent countries, given the history of 'scientific-imperialism' and 'biocolonialism' reflected in past well publicized cases of exploitation of research participants from low to middle income countries. To a considerable extent, the failure to adequately engage host communities, the opacity of informed consent, and the lack of fair benefit-sharing have played a significant role in eroding trust. These ethical considerations are central to biomedical research in low to middle income countries and failure to attend to them can inadvertently contribute to exploitation and erode trust. A 'tissue trust' may be a plausible means for enabling access to human tissues for research in a manner that is responsive to the ethical challenges considered. Preventing exploitation and restoring trust while simultaneously promoting global health research calls for innovative approaches to human tissues research. A tissue trust can reduce the risk of exploitation and promote host capacity as a key benefit.

  6. Access and use of human tissues from the developing world: ethical challenges and a way forward using a tissue trust

    Directory of Open Access Journals (Sweden)

    Upshur Ross EG

    2011-01-01

    Full Text Available Abstract Background Scientists engaged in global health research are increasingly faced with barriers to access and use of human tissues from the developing world communities where much of their research is targeted. In part, the problem can be traced to distrust of researchers from affluent countries, given the history of 'scientific-imperialism' and 'biocolonialism' reflected in past well publicized cases of exploitation of research participants from low to middle income countries. Discussion To a considerable extent, the failure to adequately engage host communities, the opacity of informed consent, and the lack of fair benefit-sharing have played a significant role in eroding trust. These ethical considerations are central to biomedical research in low to middle income countries and failure to attend to them can inadvertently contribute to exploitation and erode trust. A 'tissue trust' may be a plausible means for enabling access to human tissues for research in a manner that is responsive to the ethical challenges considered. Summary Preventing exploitation and restoring trust while simultaneously promoting global health research calls for innovative approaches to human tissues research. A tissue trust can reduce the risk of exploitation and promote host capacity as a key benefit.

  7. Gregory Bateson’s Ecology of Mind and the Understanding of Human Knowledge

    Directory of Open Access Journals (Sweden)

    Elzbieta Magdalena Wasik

    2017-01-01

    Full Text Available Departing from the biological notion of ecology that pertains to mutual relationships between organisms and their environments, this paper discusses theoretical foundations of research on the nature of human mind in relation to knowledge, cognition and communication conducted in a broader context of social sciences. It exposes the view, explicitly formulated by Gregory Bateson, that the mind is the way in which ideas are created, or just the systemic device for transmitting information in the world of all living species. In consequence, some crucial points of Bateson’s reasoning are accentuated, such as the recognition of the biological unity of organism and environment, the conviction of the necessity to study the ecology in terms of the economics of energy and material and/or the economy of information, the belief that consciousness distorts information coming to the organism from the inside and outside, which is the cause of its functional disadaptation, and the like. The conception of the ecology of an overall mind, as the sets of ideas, notions or thoughts in the whole world, is presented against the background of theoretical and empirical achievements of botany and zoology, anthropology, ethology and psychiatry, sociology and communication studies in connection with the development of cybernetics, systems theory and information theory.

  8. Human Resource Development for Knowledge-based Society and Challenges of Nagoya University

    Science.gov (United States)

    Miyata, Takashi

    Innovation in the previous century resulted in development of useful products ranging from automobiles and aircraft to cellular phones. However, the innovation and development of science and technology have changed the society and brought about negative issues. The issues emerged in the previous century remain in the excessive forms in the 21st century. The 21st century is seeing the rise of knowledge-based society, and paradigm shift is now going on. Human resources of university for creation of innovation are being called on to contribute to solving issues. Young people who pass through a doctor program must play a role as an innovator who can promote the paradigm shift. However, the higher education system of the universities in Japan is now required to be changed to dissolve the mismatch on the doctor program with industries, government and students. The discussion in the Business-University Forum of Japan for innovation of education system and a few challenges of the Nagoya University are introduced in this paper.

  9. Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

    Science.gov (United States)

    Sánchez-Martín, David; Martínez-Torrecuadrada, Jorge; Teesalu, Tambet; Sugahara, Kazuki N.; Alvarez-Cienfuegos, Ana; Ximénez-Embún, Pilar; Fernández-Periáñez, Rodrigo; Martín, M. Teresa; Molina-Privado, Irene; Ruppen-Cañás, Isabel; Blanco-Toribio, Ana; Cañamero, Marta; Cuesta, Ángel M.; Compte, Marta; Kremer, Leonor; Bellas, Carmen; Alonso-Camino, Vanesa; Guijarro-Muñoz, Irene; Sanz, Laura; Ruoslahti, Erkki; Alvarez-Vallina, Luis

    2013-01-01

    Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific antibody able to deliver a payload and unveils the target antigen. By using an ex vivo enrichment process against freshly disaggregated tumors to purge the repertoire, in combination with in vivo biopanning at optimized phage circulation time, we have identified a human domain antibody capable of mediating selective localization of phage to human prostate cancer xenografts. Affinity chromatography followed by mass spectrometry analysis showed that the antibody recognizes the proteasome activator complex PA28. The specificity of soluble antibody was confirmed by demonstrating its binding to the active human PA28αβ complex. Whereas systemically administered control phage was confined in the lumen of blood vessels of both normal tissues and tumors, the selected phage spread from tumor vessels into the perivascular tumor parenchyma. In these areas, the selected phage partially colocalized with PA28 complex. Furthermore, we found that the expression of the α subunit of PA28 [proteasome activator complex subunit 1 (PSME1)] is elevated in primary and metastatic human prostate cancer and used anti-PSME1 antibodies to show that PSME1 is an accessible marker in mouse xenograft tumors. These results support the use of PA28 as a tumor marker and a potential target for therapeutic intervention in prostate cancer. PMID:23918357

  10. How to Inform: Comparing Written and Video Education Interventions to Increase Human Papillomavirus Knowledge and Vaccination Intentions in Young Adults

    Science.gov (United States)

    Krawczyk, Andrea; Lau, Elsa; Perez, Samara; Delisle, Vanessa; Amsel, Rhonda; Rosberger, Zeev

    2012-01-01

    Objective: To compare the efficacy of 2 human papillomavirus (HPV) educational interventions on increasing HPV knowledge and vaccination intentions in college students. Participants: Male (n = 60) and female (n = 140) undergraduates (M[subscript age] = 20.4, SD = 2.3) recruited from a university in Montreal, Quebec, Canada, from October 2009 to…

  11. A Randomized Intervention Study to Evaluate Whether Electronic Messaging Can Increase Human Papillomavirus Vaccine Completion and Knowledge among College Students

    Science.gov (United States)

    Richman, Alice R.; Maddy, LaDonna; Torres, Essie; Goldberg, Ellen J.

    2016-01-01

    Objective: To evaluate an intervention aimed at increasing human papillomavirus (HPV) vaccine completion of the 3-dose series and knowledge. Participants: Two hundred sixty-four male and female US college students 18-26 years old who were receiving HPV vaccine dose 1. Methods: Students were randomly assigned to the intervention or control group.…

  12. Kinome Render: a stand-alone and web-accessible tool to annotate the human protein kinome tree.

    Science.gov (United States)

    Chartier, Matthieu; Chénard, Thierry; Barker, Jonathan; Najmanovich, Rafael

    2013-01-01

    Human protein kinases play fundamental roles mediating the majority of signal transduction pathways in eukaryotic cells as well as a multitude of other processes involved in metabolism, cell-cycle regulation, cellular shape, motility, differentiation and apoptosis. The human protein kinome contains 518 members. Most studies that focus on the human kinome require, at some point, the visualization of large amounts of data. The visualization of such data within the framework of a phylogenetic tree may help identify key relationships between different protein kinases in view of their evolutionary distance and the information used to annotate the kinome tree. For example, studies that focus on the promiscuity of kinase inhibitors can benefit from the annotations to depict binding affinities across kinase groups. Images involving the mapping of information into the kinome tree are common. However, producing such figures manually can be a long arduous process prone to errors. To circumvent this issue, we have developed a web-based tool called Kinome Render (KR) that produces customized annotations on the human kinome tree. KR allows the creation and automatic overlay of customizable text or shape-based annotations of different sizes and colors on the human kinome tree. The web interface can be accessed at: http://bcb.med.usherbrooke.ca/kinomerender. A stand-alone version is also available and can be run locally.

  13. Harnessing the Risk-Related Data Supply Chain: An Information Architecture Approach to Enriching Human System Research and Operations Knowledge

    Science.gov (United States)

    Buquo, Lynn E.; Johnson-Throop, Kathy A.

    2011-01-01

    An Information Architecture facilitates the understanding and, hence, harnessing of the human system risk-related data supply chain which enhances the ability to securely collect, integrate, and share data assets that improve human system research and operations. By mapping the risk-related data flow from raw data to useable information and knowledge (think of it as a data supply chain), the Human Research Program (HRP) and Space Life Science Directorate (SLSD) are building an information architecture plan to leverage their existing, and often shared, IT infrastructure.

  14. Linking departmental priorities to knowledge management: the experiences of Santa Cruz County's Human Services Department.

    Science.gov (United States)

    Lindberg, Arley

    2012-01-01

    Federal welfare reform, local service collaborations, and the evolution of statewide information systems inspired agency interest in evidence-informed practice and knowledge sharing systems. Four agency leaders, including the Director, Deputy Director, Director of Planning and Evaluation, and Staff Development Program Manager championed the development of a learning organization based on knowledge management throughout the agency. Internal department restructuring helped to strengthen the Planning and Evaluation, Staff Development, and Personnel units, which have become central to supporting knowledge sharing activities. The Four Pillars of Knowledge framework was designed to capture agency directions in relationship to future knowledge management goals. Featuring People, Practice, Technology and Budget, the framework links the agency's services, mission and goals to the process of becoming a learning organization. Built through an iterative process, the framework was created by observing existing activities in each department rather than being designed from the top down. Knowledge management can help the department to fulfill its mission despite reduced resources.

  15. An urgent need to restrict access to pesticides based on human lethality.

    OpenAIRE

    Matthew Miller; Kavi Bhalla

    2010-01-01

    Matthew Miller and Kavi Bhalla discuss new research findings from Andrew Dawson and colleagues on the human toxicity of pesticides in Sri Lanka, and call for urgent reclassification of agricultural pesticides to help reduce suicides by poisonings.

  16. Near-Earth Object Human Space Flight Accessible Targets Study (NHATS)

    Data.gov (United States)

    National Aeronautics and Space Administration — This list of potential mission targets should not be interpreted as a complete list of viable NEAs for an actual human exploration mission. As the NEA orbits are...

  17. Level of Knowledge about Human Papillomavirus Infection among Women of Kashan City, Iran

    OpenAIRE

    Nekooi M.S. BSc; Ayazi Sh. BSc,; Gandomi M. BSc,; Moosavi S.Gh. MSc,; Fakhri A.* PhD

    2016-01-01

    Aims A few studies concentrate on the level of knowledge of HPV. This study was conducted to evaluate the level of knowledge about HPV, its risk factors, and its relation with cervical cancer in women of Kashan City, Iran. Instrument & Methods This descriptive cross-sectional study was conducted in January 2015 in the population of the women of Kashan City, Iran, and 200 persons were selected by simple sampling method. The level of knowledge about HPV and cervical cancer were ...

  18. The state of human dimensions capacity for natural resource management: needs, knowledge, and resources

    Science.gov (United States)

    Sexton, Natalie R.; Leong, Kirsten M.; Milley, Brad J.; Clarke, Melinda M.; Teel, Tara L.; Chase, Mark A.; Dietsch, Alia M.

    2013-01-01

    The social sciences have become increasingly important in understanding natural resource management contexts and audiences, and are essential in design and delivery of effective and durable management strategies. Yet many agencies and organizations do not have the necessary resource management. We draw on the textbook definition of HD: how and why people value natural resources, what benefits people seek and derive from those resources, and how people affect and are affected by those resources and their management (Decker, Brown, and Seimer 2001). Clearly articulating how HD information can be used and integrated into natural resource management planning and decision-making is an important challenge faced by the HD field. To address this challenge, we formed a collaborative team to explore the issue of HD capacity-building for natural resource organizations and to advance the HD field. We define HD capacity as activities, efforts, and resources that enhance the ability of HD researchers and practitioners and natural managers and decision-makers to understand and address the social aspects of conservation. Specifically, we sought to examine current barriers to integration of HD into natural resource management, knowledge needed to improve HD capacity, and existing HD tools, resources, and training opportunities. We conducted a needs assessment of HD experts and practitioners, developed a framework for considering HD activities that can contribute both directly and indirectly throughout any phase of an adaptive management cycle, and held a workshop to review preliminary findings and gather additional input through breakout group discussions. This paper provides highlights from our collaborative initiative to help frame and inform future HD capacity-building efforts and natural resource organizations and also provides a list of existing human dimensions tools and resources.

  19. Rebooting the human mitochondrial phylogeny: an automated and scalable methodology with expert knowledge

    Directory of Open Access Journals (Sweden)

    Mayordomo Elvira

    2011-05-01

    Full Text Available Abstract Background Mitochondrial DNA is an ideal source of information to conduct evolutionary and phylogenetic studies due to its extraordinary properties and abundance. Many insights can be gained from these, including but not limited to screening genetic variation to identify potentially deleterious mutations. However, such advances require efficient solutions to very difficult computational problems, a need that is hampered by the very plenty of data that confers strength to the analysis. Results We develop a systematic, automated methodology to overcome these difficulties, building from readily available, public sequence databases to high-quality alignments and phylogenetic trees. Within each stage in an autonomous workflow, outputs are carefully evaluated and outlier detection rules defined to integrate expert knowledge and automated curation, hence avoiding the manual bottleneck found in past approaches to the problem. Using these techniques, we have performed exhaustive updates to the human mitochondrial phylogeny, illustrating the power and computational scalability of our approach, and we have conducted some initial analyses on the resulting phylogenies. Conclusions The problem at hand demands careful definition of inputs and adequate algorithmic treatment for its solutions to be realistic and useful. It is possible to define formal rules to address the former requirement by refining inputs directly and through their combination as outputs, and the latter are also of help to ascertain the performance of chosen algorithms. Rules can exploit known or inferred properties of datasets to simplify inputs through partitioning, therefore cutting computational costs and affording work on rapidly growing, otherwise intractable datasets. Although expert guidance may be necessary to assist the learning process, low-risk results can be fully automated and have proved themselves convenient and valuable.

  20. A SEMI-AUTOMATIC RULE SET BUILDING METHOD FOR URBAN LAND COVER CLASSIFICATION BASED ON MACHINE LEARNING AND HUMAN KNOWLEDGE

    Directory of Open Access Journals (Sweden)

    H. Y. Gu

    2017-09-01

    Full Text Available Classification rule set is important for Land Cover classification, which refers to features and decision rules. The selection of features and decision are based on an iterative trial-and-error approach that is often utilized in GEOBIA, however, it is time-consuming and has a poor versatility. This study has put forward a rule set building method for Land cover classification based on human knowledge and machine learning. The use of machine learning is to build rule sets effectively which will overcome the iterative trial-and-error approach. The use of human knowledge is to solve the shortcomings of existing machine learning method on insufficient usage of prior knowledge, and improve the versatility of rule sets. A two-step workflow has been introduced, firstly, an initial rule is built based on Random Forest and CART decision tree. Secondly, the initial rule is analyzed and validated based on human knowledge, where we use statistical confidence interval to determine its threshold. The test site is located in Potsdam City. We utilised the TOP, DSM and ground truth data. The results show that the method could determine rule set for Land Cover classification semi-automatically, and there are static features for different land cover classes.

  1. Level of Knowledge about Human Papillomavirus Infection among Women of Kashan City, Iran

    Directory of Open Access Journals (Sweden)

    Nekooi M.S. BSc

    2016-03-01

    Full Text Available Aims A few studies concentrate on the level of knowledge of HPV. This study was conducted to evaluate the level of knowledge about HPV, its risk factors, and its relation with cervical cancer in women of Kashan City, Iran. Instrument & Methods This descriptive cross-sectional study was conducted in January 2015 in the population of the women of Kashan City, Iran, and 200 persons were selected by simple sampling method. The level of knowledge about HPV and cervical cancer were measured using a questionnaire with 10 questions about knowledge. The data was analyzed in SPSS 16 software by Chi-square, Exact Fisher and Kruskal-Wallis tests. Findings Most of the participants (152 persons; 76% had “weak, 26 participants (13% had “moderate” and only 22 participants (11% had “strong” level of knowledge about HPV. There were significant differences between the level of knowledge according to educational level (p=0.014 and professional status (p0.05. In all the questions, the most frequent answer was “don’t know”. The participants had some knowledge about “HPV causing cervical cancer” (34.5%, “HPV causing genital warts” (38%, “sexually transmission of HPV” (37.5% and “increased risk of getting HPV by extramarital sexual affairs” (43.5% Conclusion The level of knowledge about HPV, genital warts, and ways of infection transmission and its preventions in women of Kashan City, Iran, is insufficient.

  2. Maglev Launch: Ultra-low Cost, Ultra-high Volume Access to Space for Cargo and Humans

    Science.gov (United States)

    Powell, James; Maise, George; Rather, John

    2010-01-01

    Despite decades of efforts to reduce rocket launch costs, improvements are marginal. Launch cost to LEO for cargo is ~$10,000 per kg of payload, and to higher orbit and beyond much greater. Human access to the ISS costs $20 million for a single passenger. Unless launch costs are greatly reduced, large scale commercial use and human exploration of the solar system will not occur. A new approach for ultra low cost access to space-Maglev Launch-magnetically accelerates levitated spacecraft to orbital speeds, 8 km/sec or more, in evacuated tunnels on the surface, using Maglev technology like that operating in Japan for high speed passenger transport. The cost of electric energy to reach orbital speed is less than $1 per kilogram of payload. Two Maglev launch systems are described, the Gen-1System for unmanned cargo craft to orbit and Gen-2, for large-scale access of human to space. Magnetically levitated and propelled Gen-1 cargo craft accelerate in a 100 kilometer long evacuated tunnel, entering the atmosphere at the tunnel exit, which is located in high altitude terrain (~5000 meters) through an electrically powered ``MHD Window'' that prevents outside air from flowing into the tunnel. The Gen-1 cargo craft then coasts upwards to space where a small rocket burn, ~0.5 km/sec establishes, the final orbit. The Gen-1 reference design launches a 40 ton, 2 meter diameter spacecraft with 35 tons of payload. At 12 launches per day, a single Gen-1 facility could launch 150,000 tons annually. Using present costs for tunneling, superconductors, cryogenic equipment, materials, etc., the projected construction cost for the Gen-1 facility is 20 billion dollars. Amortization cost, plus Spacecraft and O&M costs, total $43 per kg of payload. For polar orbit launches, sites exist in Alaska, Russia, and China. For equatorial orbit launches, sites exist in the Andes and Africa. With funding, the Gen-1 system could operate by 2020 AD. The Gen-2 system requires more advanced technology

  3. Human Papillomavirus (HPV Vaccination and Adolescent Girls' Knowledge and Sexuality in Western Uganda: A Comparative Cross-Sectional Study.

    Directory of Open Access Journals (Sweden)

    Andrew Kampikaho Turiho

    Full Text Available The purpose of the study was to investigate the influence of human papillomavirus (HPV vaccination on adolescent girls' knowledge of HPV and HPV vaccine, perception of sexual risk and intentions for sexual debut. This cross-sectional comparative study was conducted in Ibanda and Mbarara districts. Data was collected using a standardized self-administered questionnaire and analyzed using the Statistical Package for the Social Sciences computer software. Univariate, bivariate, and logistic regression analyses were conducted with significance level set at p < .05. Results showed that HPV vaccination was associated with being knowledgeable (Crude OR: 5.26, CI: 2.32-11.93; p = 0.000. Vaccination against HPV did not predict perception of sexual risk. Knowledge was low (only 87/385 or 22.6% of vaccinated girls were knowledgeable, but predicted perception of a high sexual risk (Adjusted OR: 3.12, CI: 1.37-3.63; p = 0.008. HPV vaccination, knowledge and perceived sexual risk did not predict sexual behaviour intentions. High parental communication was associated with adolescent attitudes that support postponement of sexual debut in both bivariate and multiple regression analyses. In conclusion, findings of this study suggest that HPV vaccination is not likely to encourage adolescent sexual activity. Influence of knowledge on sexual behaviour intentions was not definitively explained. Prospective cohort studies were proposed to address the emerging questions.

  4. Agent based simulation on the process of human flesh search-From perspective of knowledge and emotion

    Science.gov (United States)

    Zhu, Hou; Hu, Bin

    2017-03-01

    Human flesh search as a new net crowed behavior, on the one hand can help us to find some special information, on the other hand may lead to privacy leaking and offending human right. In order to study the mechanism of human flesh search, this paper proposes a simulation model based on agent-based model and complex networks. The computational experiments show some useful results. Discovered information quantity and involved personal ratio are highly correlated, and most of net citizens will take part in the human flesh search or will not take part in the human flesh search. Knowledge quantity does not influence involved personal ratio, but influences whether HFS can find out the target human. When the knowledge concentrates on hub nodes, the discovered information quantity is either perfect or almost zero. Emotion of net citizens influences both discovered information quantity and involved personal ratio. Concretely, when net citizens are calm to face the search topic, it will be hardly to find out the target; But when net citizens are agitated, the target will be found out easily.

  5. Ontology Based Access Control

    Directory of Open Access Journals (Sweden)

    Özgü CAN

    2010-02-01

    Full Text Available As computer technologies become pervasive, the need for access control mechanisms grow. The purpose of an access control is to limit the operations that a computer system user can perform. Thus, access control ensures to prevent an activity which can lead to a security breach. For the success of Semantic Web, that allows machines to share and reuse the information by using formal semantics for machines to communicate with other machines, access control mechanisms are needed. Access control mechanism indicates certain constraints which must be achieved by the user before performing an operation to provide a secure Semantic Web. In this work, unlike traditional access control mechanisms, an "Ontology Based Access Control" mechanism has been developed by using Semantic Web based policies. In this mechanism, ontologies are used to model the access control knowledge and domain knowledge is used to create policy ontologies.

  6. A HUMAN RIGHTS-BASED APPROACH TO POVERTY REDUCTION: THE ROLE OF THE RIGHT OF ACCESS TO MEDICINE AS AN ELEMENT OF THE RIGHT OF ACCESS TO HEALTH CARE

    Directory of Open Access Journals (Sweden)

    Zannelize Strauss

    2013-08-01

    Full Text Available The prevention and treatment of infectious diseases remain among the greatest challenges faced by today's developing countries. The World Health Organisation estimates that about one-third of the world's population lacks access to essential medicine, a fact which, according to the United Nations, directly contradicts the fundamental principle of health as a human right. According to the World Summit for Social Development, poor health and illness are factors that contribute to poverty, while the adverse effects of illness ensure that the poor become poorer. A lack of access to health care, amongst other rights, (including access to medicines as an element thereof aggravates poverty. The most important provision in international law relating to the right to health is article 12 of the United Nations International Covenant on Economic, Social and Cultural Rights. Article 12(1 of this Covenant provides a broad formulation of the right to health in international law, while article 12(2 prescribes a non-exhaustive list of steps to be taken in pursuit of the highest attainable standard of health. Article 12(2, in particular, illustrates the role that adequate access to medication plays in the right of access to health care. The United Nations Committee on Economic, Social and Cultural Rights has explicitly included the provision of essential drugs as a component of the right to health care, thereby emphasising the causal link between the lack of access to essential medicines and the non-fulfilment of the right of access to health care. As with all socio-economic rights, the resource implications of the realisation of the right to health has the result that states cannot be expected to immediately comply with its obligations in respect thereof. Instead, article 2(1 of the International Covenant on Economic, Social and Cultural Rights and the General Comments of the Committee on Economic, Social and Cultural Rights place obligations on states to take

  7. Development and Validation of an Instrument to Assess Social Work Students' Perceptions, Knowledge, and Attitudes about Human Trafficking Questionnaire (PKA-HTQ): An Exploratory Study

    Science.gov (United States)

    Nsonwu, Maura Busch; Welch-Brewer, Chiquitia; Heffron, Laurie Cook; Lemke, Melinda A.; Busch-Armendariz, Noel; Sulley, Caitlin; Cook, Sharon Warren; Lewis, Mary; Watson, Elizabeth; Moore, Wayne; Li, Jilan

    2017-01-01

    Objective: This study sought to develop and evaluate the psychometric properties of a tool designed to assess social work students' knowledge of and perceptions and attitudes toward human trafficking. To achieve this aim, the Perceptions, Knowledge, and Attitudes toward Human Trafficking Questionnaire (PKA-HTQ) was developed and its psychometric…

  8. Human papillomavirus (HPV) vaccine knowledge, attitudes, and uptake in college students: Implications from the Precaution Adoption Process Model.

    Science.gov (United States)

    Barnard, Marie; George, Phillis; Perryman, Mandy L; Wolff, Lori A

    2017-01-01

    The purpose of this study was to examine human papillomavirus (HPV) and HPV vaccine knowledge, attitudes, and uptake in college students and to identify factors associated with vaccination status utilizing the Precaution Adoption Process Model (PAPM). The sample included 383 undergraduates from a public university who participated in February and March 2015. Students were emailed an anonymous online survey assessing knowledge, attitudes, and perceptions related to HPV and HPV vaccination, as well as their stage in the PAPM regarding vaccination completion. Significantly more females (47.3%) than males (15.8%) were vaccinated. While most students had basic knowledge of HPV, they had low perceptions of their susceptibility to contract HPV. Most unvaccinated students were in the early stages of decision-making related to vaccination. Campus health centers have an opportunity to increase HPV vaccination rates. This study indicates that students need prompts from providers, as well as education regarding susceptibility to HPV.

  9. Free Access to Running Wheels Abolishes Hyperphagia in Human Growth Hormone Transgenic Rats

    OpenAIRE

    KOMATSUDA, Mugiko; Yamanouchi, Keitaro; Matsuwaki, Takashi; Nishihara, Masugi

    2014-01-01

    ABSTRACT Obesity is a major health problem, and increased food intake and decreased physical activity are considered as two major factors causing obesity. Previous studies show that voluntary exercise in a running wheel decreases not only body weight but also food intake of rats. We previously produced human growth hormone transgenic (TG) rats, which are characterized by severe hyperphagia and obesity. To gain more insight into the effects on physical activity to food consumption and obesity,...

  10. Comparing humans and nonhuman great apes in the broken cloth problem: Is their knowledge causal or perceptual?

    Science.gov (United States)

    Albiach-Serrano, Anna; Sebastián-Enesco, Carla; Seed, Amanda; Colmenares, Fernando; Call, Josep

    2015-11-01

    When presented with the broken cloth problem, both human children and nonhuman great apes prefer to pull a continuous cloth over a discontinuous cloth in order to obtain a desired object resting on top. This has been interpreted as evidence that they preferentially attend to the functionally relevant cues of the task (e.g., presence or absence of a gap along the cloth). However, there is controversy regarding whether great apes' behavior is underpinned by causal knowledge, involving abstract concepts (e.g., support, connection), or by perceptual knowledge, based on percepts (e.g., contact, continuity). We presented chimpanzees, orangutans, and 2-, 3-, and 4-year-old children with two versions of the broken cloth problem. The Real condition, made with paper strips, could be solved based on either perceptual cues or causal knowledge. The Painted condition, which looked very similar, could be solved only by attending to perceptual cues. All groups mastered the Real condition, in line with previous results. Older children (3- and 4-year-olds) performed significantly better in this condition than all other groups, but the performance of apes and children did not differ sharply, with 2-year-olds and apes obtaining similar results. In contrast, only 4-year-olds solved the Painted condition. We propose causal knowledge to explain the general good performance of apes and humans in the Real condition compared with the Painted condition. In addition, we suggest that symbolic knowledge might account for 4-year-olds' performance in the Painted condition. Our findings add to the growing literature supporting the idea that learning from arbitrary cues is not a good explanation for the performance of apes and humans on some kinds of physical task.

  11. Knowledge and perception of human papilloma virus vaccine among the antenatal women in a Nigerian tertiary hospital

    Directory of Open Access Journals (Sweden)

    Teddy E Agida

    2015-01-01

    Full Text Available Background: Cervical cancer is a major health problem globally, especially in sub-Saharan Africa, Nigeria inclusive. One of the preventive measures is the vaccination of teenagers against oncogenic human papilloma virus. The aim of this study was to find out the level of knowledge mothers possess about these vaccines and their willingness to administer vaccination to their teenage girls. Materials and Methods: This was a cross-sectional descriptive study of 255 consecutive women attending antenatal clinic at the University of Abuja Teaching Hospital, Abuja. They were given either a self-administered questionnaire or interviewer-administered questionnaire containing both closed and open-ended questions. Information recorded includes socio-demographic variables, knowledge of cervical cancer, knowledge of HPV/HPV vaccines and acceptance of these vaccines for their adolescent girls. The data was analysed using descriptive statistics. Results: The mean age of the respondents was 26.9 years. Over 90% had at least secondary education. A total of 102 (40% had the knowledge of cancer of the cervix while 153 (60% had never heard about it. Overall, 236 (92.5% of them had no idea about the predisposing factors. The study showed that only 23 (9.0% out of the total respondents had heard about human papilloma virus (HPV infection. In the same vein, 20 (7.8% had knowledge about HPV vaccine. Among the respondents, who had the knowledge of HPV and vaccination, 18.2% and 23.4% of them had secondary and tertiary levels of education respectively. Overall, 160 (62.8% accepted that the vaccines could be administered to their teenage girls. Conclusions: Awareness of cervical cancer, HPV infections, and HPV vaccines is low among antenatal clinic attendees in Gwagwalada, Abuja. However, majority of them would want their girls vaccinated against HPV infections. There is a need for all stakeholders to step up awareness creation for improved HPV vaccination project in

  12. Health care access for refugees and immigrants with precarious status: public health and human right challenges.

    Science.gov (United States)

    Rousseau, Cécile; ter Kuile, Sonia; Munoz, Marie; Nadeau, Lucie; Ouimet, Marie-Jo; Kirmayer, Laurence; Crépeau, François

    2008-01-01

    Migration flux is being transformed by globalization, and the number of people with either undocumented or with a precarious status is growing in Canada. There are no epidemiological data on the health and social consequences of this situation, but clinicians working in primary care with migrants and refugees are increasingly worried about the associated morbidity. This commentary summarizes findings from a pilot study with health professionals in the Montreal area and suggests that the uninsured population predicament is a national problem. Although ethical and legal issues associated with data collection by clinicians, institutions and governments need to be examined, estimating the public health consequences and long-term cost associated with problems in access to health care due to migratory status should be a priority. Current regulations and administrative policies appear to be at odds with the principles of equal rights set out by the Canadian Charter of Rights and Freedoms and the UN Convention on the Rights of the Child. Beyond the commitment of individual clinicians, Canadian medical associations should take an advocacy role and scrutinize the ethical and medical implications of the present system.

  13. Temporal dynamics of the knowledge-mediated visual disambiguation process in humans: a magnetoencephalography study.

    Science.gov (United States)

    Urakawa, Tomokazu; Ogata, Katsuya; Kimura, Takahiro; Kume, Yuko; Tobimatsu, Shozo

    2015-01-01

    Disambiguation of a noisy visual scene with prior knowledge is an indispensable task of the visual system. To adequately adapt to a dynamically changing visual environment full of noisy visual scenes, the implementation of knowledge-mediated disambiguation in the brain is imperative and essential for proceeding as fast as possible under the limited capacity of visual image processing. However, the temporal profile of the disambiguation process has not yet been fully elucidated in the brain. The present study attempted to determine how quickly knowledge-mediated disambiguation began to proceed along visual areas after the onset of a two-tone ambiguous image using magnetoencephalography with high temporal resolution. Using the predictive coding framework, we focused on activity reduction for the two-tone ambiguous image as an index of the implementation of disambiguation. Source analysis revealed that a significant activity reduction was observed in the lateral occipital area at approximately 120 ms after the onset of the ambiguous image, but not in preceding activity (about 115 ms) in the cuneus when participants perceptually disambiguated the ambiguous image with prior knowledge. These results suggested that knowledge-mediated disambiguation may be implemented as early as approximately 120 ms following an ambiguous visual scene, at least in the lateral occipital area, and provided an insight into the temporal profile of the disambiguation process of a noisy visual scene with prior knowledge.

  14. Open Access: (Social Sciences as Public Good

    Directory of Open Access Journals (Sweden)

    Katja Mruck

    2004-05-01

    Full Text Available The need to provide open access to articles published in peer-reviewed scholarly journals is becoming apparent to researchers as well as the non-scientific public as a result of "Budapest Open Access Initiative," the "Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities" and other initiatives. The core question that concerns open access is the following: since scientific information is usually financed by public funding, and therefore a public good, shouldn't the access be free of cost to all interested parties. Currently the open access movement is encountering the movement against the "Digital Divide," and therefore it is not surprising that the demand for open access has extended to a political level as reflected in the "WSIS Declaration of Principles" and the "WSIS Plan of Action." This article begins by providing a brief summary of the historical background of the open access movement and its major aims (Section 2. It then lists examples that explain possible links between the open access movement and the initiatives against the "Digital Divide" (Section 3. Section 4 considers some important barriers responsible for the fact that open access publishing is still not part of the everyday scientific publishing practices. This has various consequences. Selected consequences concerning the recent debate on redistribution processes between "information poor" and "information rich" are summarized in Section 5. URN: urn:nbn:de:0114-fqs0402141

  15. Globalisation of innovation in knowledge intensive industries

    DEFF Research Database (Denmark)

    Chen, Yun-Chung; Vang, Jan; Chaminade, Cristina

    2012-01-01

    in developing countries: reduce research costs, access large markets, tap into a large pool of qualified human resources or benefit from knowledge spillovers available in the local/regional system of innovation. The empirical research presented in this paper reveals that none of these arguments can fully...

  16. Equity in human papilloma virus vaccination uptake? : sexual behaviour, knowledge and demographics in a cross-sectional study in (un)vaccinated girls in the Netherlands

    NARCIS (Netherlands)

    Mollers, Madelief; Lubbers, Karin; Spoelstra, Symen K; Weijmar Schultz, Willibrordus; Daemen, Toos; Westra, Tjalke A; van der Sande, Marianne A B; Nijman, Hans W; de Melker, Hester E; Tami, Adriana

    2014-01-01

    Background: In the Netherlands, human papillomavirus (HPV) vaccination is part of a national program equally accessible for all girls invited for vaccination. To assess possible inequalities in vaccine uptake, we investigated differences between vaccinated and unvaccinated girls with regard to

  17. Human Papillomavirus (HPV) Vaccination and Adolescent Girls' Knowledge and Sexuality in Western Uganda: A Comparative Cross-Sectional Study.

    Science.gov (United States)

    Turiho, Andrew Kampikaho; Muhwezi, Wilson Winston; Okello, Elialilia Sarikiaeli; Tumwesigye, Nazarius Mbona; Banura, Cecil; Katahoire, Anne Ruhweza

    2015-01-01

    The purpose of the study was to investigate the influence of human papillomavirus (HPV) vaccination on adolescent girls' knowledge of HPV and HPV vaccine, perception of sexual risk and intentions for sexual debut. This cross-sectional comparative study was conducted in Ibanda and Mbarara districts. Data was collected using a standardized self-administered questionnaire and analyzed using the Statistical Package for the Social Sciences computer software. Univariate, bivariate, and logistic regression analyses were conducted with significance level set at p sexual risk. Knowledge was low (only 87/385 or 22.6% of vaccinated girls were knowledgeable), but predicted perception of a high sexual risk (Adjusted OR: 3.12, CI: 1.37-3.63; p = 0.008). HPV vaccination, knowledge and perceived sexual risk did not predict sexual behaviour intentions. High parental communication was associated with adolescent attitudes that support postponement of sexual debut in both bivariate and multiple regression analyses. In conclusion, findings of this study suggest that HPV vaccination is not likely to encourage adolescent sexual activity. Influence of knowledge on sexual behaviour intentions was not definitively explained. Prospective cohort studies were proposed to address the emerging questions.

  18. Knowledge Development in Internship

    DEFF Research Database (Denmark)

    Dau, Susanne

    2015-01-01

    The purpose of the chapter is to shed light on how these challenges and tendencies affect students’´ access to tacit and explicit knowledge and the professions’ knowledge development. To address these challenges, the chapter examines the question: How might periods of internship, offering different...... kinds of access to tacit and explicit knowledge by apprenticeship and reflection, have consequences for both students’ learning and the professions’ knowledge development?...

  19. Access to bacteriophage therapy: discouraging experiences from the human cell and tissue legal framework.

    Science.gov (United States)

    Verbeken, G; Huys, I; De Vos, D; De Coninck, A; Roseeuw, D; Kets, E; Vanderkelen, A; Draye, J P; Rose, T; Jennes, S; Ceulemans, C; Pirnay, J P

    2016-02-01

    Cultures of human epithelial cells (keratinocytes) are used as an additional surgical tool to treat critically burnt patients. Initially, the production environment of keratinocyte grafts was regulated exclusively by national regulations. In 2004, the European Tissues and Cells Directive 2004/23/EC (transposed into Belgian Law) imposed requirements that resulted in increased production costs and no significant increase in quality and/or safety. In 2007, Europe published Regulation (EC) No. 1394/2007 on Advanced Therapy Medicinal Products. Overnight, cultured keratinocytes became (arguably) 'Advanced' Therapy Medicinal Products to be produced as human medicinal products. The practical impact of these amendments was (and still is) considerable. A similar development appears imminent in bacteriophage therapy. Bacteriophages are bacterial viruses that can be used for tackling the problem of bacterial resistance development to antibiotics. Therapeutic natural bacteriophages have been in clinical use for almost 100 years. Regulators today are framing the (re-)introduction of (natural) bacteriophage therapy into 'modern western' medicine as biological medicinal products, also subject to stringent regulatory medicinal products requirements. In this paper, we look back on a century of bacteriophage therapy to make the case that therapeutic natural bacteriophages should not be classified under the medicinal product regulatory frames as they exist today. It is our call to authorities to not repeat the mistake of the past.

  20. Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own Hands.

    Science.gov (United States)

    Santosa, Munirah Mohamad; Low, Blaise Su Jun; Pek, Nicole Min Qian; Teo, Adrian Kee Keong

    2015-01-01

    In the field of stem cell biology and diabetes, we and others seek to derive mature and functional human pancreatic β cells for disease modeling and cell replacement therapy. Traditionally, knowledge gathered from rodents is extended to human pancreas developmental biology research involving human pluripotent stem cells (hPSCs). While much has been learnt from rodent pancreas biology in the early steps toward Pdx1(+) pancreatic progenitors, much less is known about the transition toward Ngn3(+) pancreatic endocrine progenitors. Essentially, the later steps of pancreatic β cell development and maturation remain elusive to date. As a result, the most recent advances in the stem cell and diabetes field have relied upon combinatorial testing of numerous growth factors and chemical compounds in an arbitrary trial-and-error fashion to derive mature and functional human pancreatic β cells from hPSCs. Although this hit-or-miss approach appears to have made some headway in maturing human pancreatic β cells in vitro, its underlying biology is vaguely understood. Therefore, in this mini-review, we discuss some of these late-stage signaling pathways that are involved in human pancreatic β cell differentiation and highlight our current understanding of their relevance in rodent pancreas biology. Our efforts here unravel several novel signaling pathways that can be further studied to shed light on unexplored aspects of rodent pancreas biology. New investigations into these signaling pathways are expected to advance our knowledge in human pancreas developmental biology and to aid in the translation of stem cell biology in the context of diabetes treatments.

  1. Impact of health education on knowledge regarding human immunodeficiency virus/acquired immunodeficiency syndrome.

    Science.gov (United States)

    Angadi, M M; Sorganvi, V S; Algur, V S

    2013-01-01

    The aims of the study were to determine the knowledge of HIV/AIDS among college girl students, to expose the college girl students to targeted HIV/AIDS education and to assess the impact of HIV/ AIDS health education on college girl students. A cross-sectional study was designed over the period September 2009 to February 2010. Study participants included 139 students of BLDEA's Arts and Commerce College for Women, Bijapur, Karnataka. Results indicated knowledge regarding HIV/ AIDS improved substantially, especially, with relation to various modes of transmission viz unsterilised syringes (41% to 72%), pregnant mother to child (23% to 66%) blood transfusion (20% to71%) and regarding preventive measures namely adherence to single partner (68% to 95%), use of condom (18% to 68%/), use of tested blood for transfusion (21% to 55%). The study showed significant difference between pre and post-test knowledge regarding HIV/AIDS

  2. Improving Human-Computer Interaction by Developing Culture-sensitive Applications based on Common Sense Knowledge

    CERN Document Server

    Anacleto, Junia Coutinho

    2010-01-01

    The advent of Web 3.0, claiming for personalization in interactive systems (Lassila & Hendler, 2007), and the need for systems capable of interacting in a more natural way in the future society flooded with computer systems and devices (Harper et al., 2008) show that great advances in HCI should be done. This chapter presents some contributions of LIA for the future of HCI, defending that using common sense knowledge is a possibility for improving HCI, especially because people assign meaning to their messages based on their common sense and, therefore, the use of this knowledge in developing user interfaces can make them more intuitive to the end-user. Moreover, as common sense knowledge varies from group to group of people, it can be used for developing applications capable of giving different feedback for different target groups, as the applications presented along this chapter illustrate, allowing, in this way, interface personalization taking into account cultural issues. For the purpose of using com...

  3. Hubungan antara Knowledge-Technology-Innovation (KTI, Commitment, Competence, Leadership, Government Policy, Human Capital, dan Competitive Advantage

    Directory of Open Access Journals (Sweden)

    Darjat Sudrajat

    2014-05-01

    Full Text Available In current tight competitive situation, companies always try to create differentiation anytime to achieve better and sustainable performance. Rapid and unpredictable changes insist the companies should always be innovative, so that aspects of globalization, e-business, technology innovation, creativity, global competition, knowledge creation, diffusion of new technologies and knowledge revolution should be sources of performance and competitiveness improvement. Therefore, tomaintain core competencies and competitive advantage, the companies should develop continuous innovation, technologylearning, and knowledge management. Knowledge-Technology-Innovation (KTI can be a driver for country’s development and growth. Japan, South Korea, and Singapore are the countries that have limited natural and human resources, but able to achieve sustainable economic development. KTI is not only to be practiced at individual and organizational level, but also can be implemented at the community, national, or state level. KTI, therefore, can encourage expected competitive advantage creation and become a decisive factor for a country to achieve stable and sustainable economic growth. This research intends to analyze relationships of KTI, competitive advantage, commitment, leadership, human capital, government policy,and competence. This research used correlational method and literature study approach. The result of this research is a relationship model of each of these aspects that can be used as a framework for further research. The relationships model isas follows: Leadership, competence, and human capital (as independent variables have direct relationship (influence oncompetitive advantage (dependent variable or indirectly (through KTI as an intervening variable; KTI has direct relationship (effect on competitive advantage; Government policy and commitment are moderator variables for relationshipof KTI and competitive advantage.

  4. HUBUNGAN ANTARA KNOWLEDGE-TECHNOLOGY-INNOVATION (KTI, COMMITMENT, COMPETENCE, LEADERSHIP, GOVERNMENT POLICY, HUMAN CAPITAL, DAN COMPETITIVE ADVANTAGE

    Directory of Open Access Journals (Sweden)

    Darjat Sudrajat

    2014-07-01

    Full Text Available In current tight competitive situation, companies always try to create differentiation anytime to achieve better and sustainable performance. Rapid and unpredictable changes insist the companies should always be innovative, so that aspects of globalization, e-business, technology innovation, creativity, global competition, knowledge creation, diffusion of new technologies and knowledge revolution should be sources of performance and competitiveness improvement. Therefore, to maintain core competencies and competitive advantage, the companies should develop continuous innovation, technology learning, and knowledge management. Knowledge-Technology-Innovation (KTI can be a driver for countrys development and growth. Japan, South Korea, and Singapore are the countries that have limited natural and human resources, but able to achieve sustainable economic development. KTI is not only to be practiced at individual and organizational level, but also can be implemented at the community, national, or state level. KTI, therefore, can encourage expected competitive advantage creation and become a decisive factor for a country to achieve stable and sustainable economic growth. This research intends to analyze relationships of KTI, competitive advantage, commitment, leadership, human capital, government policy, and competence. This research used correlational method and literature study approach. The result of this research is a relationship model of each of these aspects that can be used as a framework for further research. The relationships model is as follows: Leadership, competence, and human capital (as independent variables have direct relationship (influence on competitive advantage (dependent variable or indirectly (through KTI as an intervening variable; KTI has direct relationship (effect on competitive advantage; Government policy and commitment are moderator variables for relationship of KTI and competitive advantage.

  5. The human capital in the knowledge society. Theoretical and empirical approach

    Directory of Open Access Journals (Sweden)

    Elena Pelinescu

    2014-12-01

    Full Text Available We live today in a changing society based on the globalization and better valorisation of the human capital. The human capital is the central driver force for competitiveness and development of the new technology and patent and a necessary factor for their efficient use in the new society. In order to reach the competitiveness objective, the European Union member countries seek to develop their human capital value by increasing investment in education, science and technology development. Based on the panel econometrics techniques, this paper explores the statistical correlations between human capital components and national competitiveness within the EU economic context.

  6. Accessible chromatin structure permits factors Sp1 and Sp3 to regulate human TGFBI gene expression.

    Science.gov (United States)

    Lee, Jong-Joo; Park, Keunhee; Shin, Myeong Heon; Yang, Wook-Jin; Song, Min-Ji; Park, Joo-Hong; Yong, Tai-Soon; Kim, Eung Kweon; Kim, Hyoung-Pyo

    2011-06-03

    Transforming growth factor beta 1-induced (TGFBI) protein is an extracellular matrix (ECM) protein that is associated with other ECM proteins and functions as a ligand for various types of integrins. In this study, we investigated how human TGFBI expression is regulated in lung and breast cancer cells. We observed that the TGFBI promoter in A549 and MBA-MD-231 cells, which constitutively express TGFBI, existed in an open chromatin conformation associated with transcriptionally permissive histone modifications. Moreover, we found that TGFBI expression required Sp1 transcription elements that can bind transcription factors Sp1 and Sp3 in vitro. Occupancy of the TGFBI promoter by Sp1 and Sp3 in vivo was only observed in TGFBI-expressing cells, indicating that open chromatin conformation might facilitate the binding of Sp1 and Sp3 to the TGFBI promoter region. TGFBI promoter activity was impaired when Sp1 elements were mutated, but was increased when Sp1 or Sp3 factors was overexpressed. Furthermore, Sp1 inhibition in vivo by mithramycin A, as well as knockdown of Sp1 and/or Sp3 expression by short interfering RNA, significantly reduced TGFBI mRNA and protein levels. Thus, our data demonstrated that the expression of TGFBI is well correlated with chromatin conformation at the TGFBI promoter, and that factors Sp1 and Sp3 are the primary determinants for the control of constitutive expression of TGFBI gene. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Can International Human Rights Law Help Restore Access to Justice for Disabled Workers?

    Directory of Open Access Journals (Sweden)

    Rupert Harwood

    2016-04-01

    Full Text Available The research literature indicates that legislative changes in recent years, including the introduction of tribunal fees, have made it harder for workers in general to enforce their rights under UK employment laws. Drawing on the author’s qualitative study, conducted in 2015 and with information from 265 participants, this paper finds that these legislative changes could be having disproportionate adverse impacts on disabled workers. Of particular note, fees had deterred substantial numbers from submitting discrimination claims; and it appeared that this reluctance to take legal action had in turn emboldened some employers to commit what might have been found to constitute unlawful acts if taken to tribunal. The paper goes onto consider whether these adverse impacts on disabled workers could render fees unlawful under UK and European equality and human rights law and/or could entail violations of rights under the United Nations Convention on the Rights of Persons with Disabilities. The paper concludes that the intent behind UK laws might (in relation to the lawfulness of fees have been frustrated in the domestic courts and that the impact of any future successes in the domestic courts, or under international law, might be dependent upon public opinion and political expediency. The paper also briefly compares developments in Britain with developments in neighbouring and other comparable jurisdictions.

  8. Changes in knowledge of cervical cancer following introduction of human papillomavirus vaccine among women at high risk for cervical cancer

    Science.gov (United States)

    Stewart Massad, L.; Evans, Charlesnika T.; Weber, Kathleen M.; D'Souza, Gypsyamber; Hessol, Nancy A.; Wright, Rodney L.; Colie, Christine; Strickler, Howard D.; Wilson, Tracey E.

    2015-01-01

    Purpose To describe changes in knowledge of cervical cancer prevention, human papillomavirus (HPV), and HPV vaccination among women at high risk for cervical cancer in the first five years after introduction of HPV vaccination. Methods In 2007, 2008–9, and 2011, women in a multicenter U.S. cohort study completed 44-item self-report questionnaires assessing knowledge of cervical cancer prevention, HPV, and HPV vaccination. Results across time were assessed for individuals, and three study enrollment cohorts were compared. Knowledge scores were correlated with demographic variables, measures of education and attention, and medical factors. Associations were assessed in multivariable models. Results In all, 974 women completed three serial questionnaires; most were minority, low income, and current or former smokers. The group included 652 (67%) HIV infected and 322 (33%) uninfected. Summary knowledge scores (possible range 0–24) increased from 2007 (12.8, S.D. 5.8) to 2008–9 (13.9, S.D. 5.3, P < 0.001) and to 2011 (14.3, S.D. 5.2, P < 0.0001 vs 2007 and < 0.04 vs 2008–9). Higher knowledge scores at first and follow-up administration of questionnaires, higher income, and higher education level were associated with improved knowledge score at third administration. Women not previously surveyed had scores similar to those of the longitudinal group at baseline. Conclusion Substantial gaps in understanding of HPV and cervical cancer prevention exist despite years of health education. While more effective educational interventions may help, optimal cancer prevention may require opt-out vaccination programs that do not require nuanced understanding. PMID:25870859

  9. Knowledge of the human immunodeficiency virus among final year dental students.

    Science.gov (United States)

    Gilbert, A D; Nuttall, N M

    1994-08-01

    A sound basis of knowledge about HIV infection and AIDS is essential to allow students to develop as dentists who undertake appropriate measures during clinical practice. In addition, it is also likely that possessing appropriate information may instil confidence in their own ability to diagnose and then manage patients infected by HIV. A questionnaire designed to test the knowledge of final year dental students in the UK was completed by 60.5% of students in 15 out of the 16 dental schools in the UK. Generally, the students rated the teaching they had received about cross-infection precautions, virology, sterilization practice and procedures and recognition of blood-borne virus risk groups as adequate or more than adequate. However, there was a lower degree of satisfaction expressed for instruction in the management of blood-borne virus carriers and the performance of barrier dentistry. Most dental students were aware of the association of hairy leukoplakia, oral Kaposi's sarcoma, oral candidiasis as a whole, and thrush as one clinical variant, with HIV infection but there was a much lower level of knowledge of erythematous candidiasis, HIV-associated salivary gland disease, oral melanotic hyperpigmentation and idiopathic thrombocytopenic purpura. This study highlights some important gaps in the knowledge of final year dental students about HIV and AIDS.

  10. Knowledge Management of Web Financial Reporting in Human-Computer Interactive Perspective

    Science.gov (United States)

    Wang, Dong; Chen, Yujing; Xu, Jing

    2017-01-01

    Handling and analyzing to web financial data is becoming a challenge issue in knowledge management and education to accounting practitioners. eXtensible Business Reporting Language (XBRL), which is a type of web financial reporting, describes and recognizes financial items by tagging metadata. The goal is to make it possible for financial reports…

  11. Emergency Contraception Education for Health and Human Service Professionals: An Evaluation of Knowledge and Attitudes

    Science.gov (United States)

    Colarossi, Lisa; Billowitz, Marissa; Breitbart, Vicki

    2010-01-01

    Objective: To assess the knowledge and attitudes of health care providers, health educators, and social service providers before and after a training session on emergency contraceptive pills. Design: A survey study using pre-post training measurements. Setting: Two hundred and twenty-three medical, social service, and health education providers in…

  12. Assessment of entrepreneurship pedagogy on entrepreneurship knowledge and entrepreneurial human capital asset: A conceptual model

    OpenAIRE

    Chidimma Odira Okeke; David Gun Fie Yong

    2016-01-01

    This study is an effort to propose a conceptual model to measure the impact assessment of entrepreneurship pedagogic. It delineates entrepreneurship education pedagogic into four dimensions and opined specific level for each dimension. Reviewing the entrepreneurship education programme, assessment of entrepreneurship pedagogic evaluates the structure that influence growth mindset development through embedded heuristic strategies, thus, the impact on entrepreneurship knowledge and entrepreneur...

  13. Prior knowledge about objects determines neural color representation in human visual cortex

    NARCIS (Netherlands)

    Vandenbroucke, A.R.E.; Fahrenfort, J.J.; Meuwese, J.D.I.; Scholte, H.S.; Lamme, V.A.F.

    2016-01-01

    To create subjective experience, our brain must translate physical stimulus input by incorporating prior knowledge and expectations. For example, we perceive color and not wavelength information, and this in part depends on our past experience with colored objects ( Hansen et al. 2006; Mitterer and

  14. A Lovely Building for Difficult Knowledge: The Architecture of the Canadian Museum for Human Rights

    Science.gov (United States)

    Wodtke, Larissa

    2015-01-01

    One only needs to look at the Canadian Museum for Human Rights (CMHR) logo, with its abstract outline of the CMHR building, to see the way in which the museum's architecture has come to stand for the CMHR's immaterial meanings and content. The CMHR's architecture becomes a material intersection of discourses of cosmopolitanism, human rights, and…

  15. An Examination of the Human Factors Attitudes and Knowledge of Surface Warfare Officers

    Science.gov (United States)

    2009-12-01

    result from a single error. This idea is captured by the most widely known model of accident causation of human error—the “Swiss Cheese ” model (Reason...London: Lloyds List Events. Booher, H. (2003). Handbook of human systems integration. New Jersey: John Wiley & Sons. Canadian Transportation

  16. A Lovely Building for Difficult Knowledge: The Architecture of the Canadian Museum for Human Rights

    Science.gov (United States)

    Wodtke, Larissa

    2015-01-01

    One only needs to look at the Canadian Museum for Human Rights (CMHR) logo, with its abstract outline of the CMHR building, to see the way in which the museum's architecture has come to stand for the CMHR's immaterial meanings and content. The CMHR's architecture becomes a material intersection of discourses of cosmopolitanism, human rights, and…

  17. Knowledge Creation and Human Capital for Development: The Role of Graduate Entrepreneurship

    Science.gov (United States)

    Mitra, Jay; Abubakar, Y. A.; Sagagi, M.

    2011-01-01

    Purpose: Tackling structural and emergent problems in the labour market, valorising skilled human capital (HC) for opportunity creation, economic development and growth, are some of the key drivers for graduate entrepreneurship. This paper aims to examine developments in Africa, focusing on the significance of improving human capital through…

  18. Building organizational supports for knowledge sharing in county human service organizations: a cross-case analysis of works-in-progress.

    Science.gov (United States)

    Lee, Chris; Austin, Michael J

    2012-01-01

    Building on the literature related to evidence-based practice, knowledge management, and learning organizations, this cross-case analysis presents twelve works-in-progress in ten local public human service organizations seeking to develop their own knowledge sharing systems. The data for this cross-case analysis can be found in the various contributions to this Special Issue. The findings feature the developmental aspects of building a learning organization that include knowledge sharing systems featuring transparency, self-assessment, and dissemination and utilization. Implications for practice focus on the structure and processes involved in building knowledge sharing teams inside public human service organizations. Copyright © Taylor & Francis Group, LLC

  19. Knowledge on the subject of human physiology among Polish high school students--a cross-sectional study.

    Science.gov (United States)

    Zwinczewska, Helena; Rozwadowska, Joanna; Traczyk, Anna; Majda, Szymon; Wysocki, Michał; Grabowski, Kamil; Kopeć, Sylwia; Głowacki, Roman; Węgrzyn, Katarzyna; Tomaszewski, Krzysztof A; Walocha, Jerzy A

    2014-01-01

    In most cases the only knowledge an individual will receive with regards to their own body and its proper functioning is during their high school education. The aim of this study was to evaluate high school students' knowledge about basic physiology. The research was carried out in five, randomly chosen high schools in Krakow, Poland. Young people in the age of 17-19 years were asked to fill in the questionnaire designed by the authors. The first part of the survey included personal data. The second part contained 20 close-ended questions assessing students' knowledge about the basics of human physiology. Question difficulty varied from easy through average, and up to difficult. The maximum number of points to achieve was 20. One-thousand-and eighty-three (out of 1179 invited--91.86%) Polish high school students (63.25% female) filled in a 20-item questionnaire constructed by the authors regarding basic human physiology. The mean age of the group was 17.66 ± 0.80 years. The mean score among the surveyed was 10.15 ± 3.48 (range 0-20). Only 26.04% of students achieved a grade of 60% or more, and only one person obtained the highest possible score. Females achieved significantly better scores than males (10.49 ± 3.38 vs. 9.56 ± 3.56; p students did not know that mature red blood cells do not have cell nuclei and a similar number of them answered that humans have 500,000 erythrocytes in 1 mm3 of blood. Over 32% believed that plasma does not participate in the transport of respiratory gases, and 31% believed that endocrine glands secrete hormones within their immediate vicinity and into the blood. Our research has shown that young people, especially men, often lack basic physiological knowledge needed to make conscious and responsible decisions regarding their health. Our results suggest that more emphasis should be put on properly teaching human physiology in high school, especially to those students who do not plan a career in medicine-related fields. This study

  20. Quality of life, socioeconomic profile, knowledge and attitude toward sexuality from the perspectives of individuals living with Human Immunodeficiency Virus

    Directory of Open Access Journals (Sweden)

    Meiry Fernanda Pinto Okuno

    2015-04-01

    Full Text Available Objectives: to analyze the quality of life of "patients" with Human Immunodeficiency Virus and relate it to their socioeconomic profile, knowledge and attitudes toward sexuality. Method: crosssectional and analytical study with 201 individuals who are 50 years old or older. The Targeted Quality of Life and Aging Sexual Knowledge and Attitudes Scales were applied during interviews. Multiple Linear Regression was used in data analysis. Results: dimensions of quality of life more strongly compromised were disclosure worries (39.0, sexual function (45.9, and financial worries (55.6. Scores concerning knowledge and attitudes toward sexuality were 31.7 and 14.8, respectively. There was significant correlation between attitudes and the domains of overall function, health worries, medication worries, and HIV mastery. Conclusion: guidance concerning how the disease is transmitted, treated and how it progresses, in addition to providing social and psychological support, could minimize the negative effects of the disease on the quality of life of patients living with the Human Immunodeficiency Virus.

  1. Digital Scholarship and Open Access

    Science.gov (United States)

    Losoff, Barbara; Pence, Harry E.

    2010-01-01

    Open access publications provide scholars with unrestricted access to the "conversation" that is the basis for the advancement of knowledge. The large number of open access journals, archives, and depositories already in existence demonstrates the technical and economic viability of providing unrestricted access to the literature that is the…

  2. Digital Scholarship and Open Access

    Science.gov (United States)

    Losoff, Barbara; Pence, Harry E.

    2010-01-01

    Open access publications provide scholars with unrestricted access to the "conversation" that is the basis for the advancement of knowledge. The large number of open access journals, archives, and depositories already in existence demonstrates the technical and economic viability of providing unrestricted access to the literature that is the…

  3. Assessing knowledge of human papillomavirus and collecting data on sexual behavior: computer assisted telephone versus face to face interviews

    Directory of Open Access Journals (Sweden)

    Garland Suzanne

    2009-11-01

    Full Text Available Abstract Background Education campaigns seeking to raise awareness of human papillomavirus (HPV and promoting HPV vaccination depend on accurate surveys of public awareness and knowledge of HPV and related sexual behavior. However, the most recent population-based studies have relied largely on computer-assisted telephone interviews (CATI as opposed to face to face interviews (FTFI. It is currently unknown how these survey modes differ, and in particular whether they attract similar demographics and therefore lead to similar overall findings. Methods A comprehensive survey of HPV awareness and knowledge, including sexual behavior, was conducted among 3,045 Singaporean men and women, half of whom participated via CATI, the other half via FTFI. Results Overall levels of awareness and knowledge of HPV differed between CATI and FTFI, attributable in part to demographic variations between these survey modes. Although disclosure of sexual behavior was greater when using CATI, few differences between survey modes were found in the actual information disclosed. Conclusion Although CATI is a cheaper, faster alternative to FTFI and people appear more willing to provide information about sexual behavior when surveyed using CATI, thorough assessments of HPV awareness and knowledge depend on multiple survey modes.

  4. Romanian adolescents' knowledge and attitudes towards human papillomavirus infection and prophylactic vaccination.

    Science.gov (United States)

    Maier, Călina; Maier, Traian; Neagu, Cristina E; Vlădăreanu, Radu

    2015-12-01

    Since licensure of HPV vaccine in 2006, HPV vaccine coverage among Romanian adolescents remains worryingly low. The objectives of the study were to assess the knowledge and attitudes towards HPV infection and vaccination among Romanian adolescents and to explore the barriers to HPV vaccination with a view to developing strategies for expanding primary HPV infection prevention. This study was conducted in Bucharest between April and June 2015. A total of 524 adolescents aged 16-18 years old were recruited from the first two general highschools in Bucharest (according to the admission grade) and completed a self-administered questionnaire including demographics, HPV related and Papanicolau smear test knowledge. Odds ratio and 95% confidence intervals were used to identify the strength of association. Logistic regression analysis was used to identify the effect of demographic characteristics on the level of knowledge and HPV vaccination rate. Associations were considered statistically significant at pPapanicolau smear test, that is, 20.22%, 67.92% and 22.9%, respectively. The overall vaccination rate for this group was 2.3%. The most common reason for not receiving the HPV vaccine was the lack of information (80.6%) followed by parents' concerns regarding safety (11%), fear of pain (5.59%) and not being sexually active (2.7%). However, 97.7% of the respondents declared interest in receiving more information about HPV. According to demographic characteristics, age at first sexual intercourse over 16 years old, monthly household income over one thousand euros and self-perceived good relationship with family members were statistically associated on a multivariate logistic regression analysis with a high HPV knowledge score and rate of vaccination. This study shows a low level of knowledge about HPV infection and prophylactic vaccination among Romanian adolescents which may be one of the most important factors for the alarmingly low HPV vaccination rate. We specifically

  5. Evaluation of the Effect of a Promotora-led Educational Intervention on Cervical Cancer and Human Papillomavirus Knowledge Among Predominantly Hispanic Primary Care Patients on the US-Mexico Border.

    Science.gov (United States)

    Molokwu, Jennifer; Penaranda, Eribeth; Flores, Silvia; Shokar, Navkiran K

    2016-12-01

    Despite declining cervical cancer rates, ethnic minorities continue to bear an unequal burden in morbidity and mortality. While access to screening is a major barrier, low levels of knowledge and cultural influences have been found to play a part in underutilization of preventive services. The aim of our study was to evaluate the effect of a promontora-led educational intervention on cervical cancer and human papillomavirus knowledge in mainly Hispanic females attending a primary care clinic. One hundred ten females were recruited from the waiting room of a busy primary care clinic and invited to attend individual or small group educational sessions. Participants completed knowledge surveys pre- and post-intervention. An overall evaluation of the educational session was also completed. Following the educational intervention, participants showed an improvement in knowledge scores from a mean score of 10.8 (SD 3.43) out of a possible score of 18 to a mean score of 16.0 (SD1.51) (p cervical cancer. An educational intervention delivered by well-trained Promotora/Lay health care worker significantly improves patient's cervical cancer and HPV knowledge and can be a useful tool in patient education in the clinical setting especially with high risk populations.

  6. Imprisoned and imperiled: access to HIV and TB prevention and treatment, and denial of human rights, in Zambian prisons

    Directory of Open Access Journals (Sweden)

    Todrys Katherine W

    2011-02-01

    Full Text Available Abstract Background Although HIV and tuberculosis (TB prevalence are high in prisons throughout sub-Saharan Africa, little research has been conducted on factors related to prevention, testing and treatment services. Methods To better understand the relationship between prison conditions, the criminal justice system, and HIV and TB in Zambian prisons, we conducted a mixed-method study, including: facility assessments and in-depth interviews with 246 prisoners and 30 prison officers at six Zambian prisons; a review of Zambian legislation and policy governing prisons and the criminal justice system; and 46 key informant interviews with government and non-governmental organization officials and representatives of international agencies and donors. Results The facility assessments, in-depth interviews and key informant interviews found serious barriers to HIV and TB prevention and treatment, and extended pre-trial detention that contributed to overcrowded conditions. Disparities both between prisons and among different categories of prisoners within prisons were noted, with juveniles, women, pre-trial detainees and immigration detainees significantly less likely to access health services. Conclusions Current conditions and the lack of available medical care in Zambia's prisons violate human rights protections and threaten prisoners' health. In order to protect the health of prisoners, prison-based health services, linkages to community-based health care, general prison conditions and failures of the criminal justice system that exacerbate overcrowding must be immediately improved. International donors should work with the Zambian government to support prison and justice system reform and ensure that their provision of funding in such areas as health services respect human rights standards, including non-discrimination. Human rights protections against torture and cruel, inhuman or degrading treatment, and criminal justice system rights, are

  7. Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans

    DEFF Research Database (Denmark)

    Maiani, Giuseppe; Castón, María Jesús Periago; Catasta, Giovina

    2009-01-01

    Carotenoids are one of the major food micronutrients in human diets and the overall objective of this review is to re-examine the role of carotenoids in human nutrition. We have emphasized the attention on the following carotenoids present in food and human tissues: -carotene, -cryptoxanthin......, -carotene, lycopene, lutein and zeaxanthin; we have reported the major food sources and dietary intake of these compounds. We have tried to summarize positive and negative effects of food processing, storage, cooking on carotenoid content and carotenoid bioavailability. In particular, we have evidenced...... the possibility to improve carotenoids bioavailability in accordance with changes and variations of technology procedures....

  8. Respecting the right to access to medicines: Implications of the UN Guiding Principles on Business and Human Rights for the pharmaceutical industry.

    Science.gov (United States)

    Moon, Suerie

    2013-06-14

    What are the human rights responsibilities of pharmaceutical companies with regard to access to medicines? The state-based international human rights framework has long struggled with the issue of the human rights obligations of non-state actors, a question sharpened by economic globalization and the concomitant growing power of private for-profit actors ("business"). In 2011, after a six-year development process, the UN Human Rights Council unanimously endorsed the Guiding Principles advanced by the UN Secretary General's Special Representative on Business and Human Rights, John Ruggie. The Ruggie Principles sought to clarify and differentiate the responsibilities of states and non-state actors-in this case, "business" -with respect to human rights. The framework centered on "three core principles: the state duty to protect against human rights abuses by third parties, including business; the corporate responsibility to respect human rights; and the need for more effective access to remedies." The "Protect, Respect, and Remedy" Framework emerged from a review of many industrial sectors operating from local to global scales, in many regions of the world, and involving multiple stakeholder consultations. However, their implications for the pharmaceutical industry regarding access to medicines remain unclear. This article analyzes the 2008 Human Rights Guidelines for Pharmaceutical Companies in relation to Access to Medicines advanced by then-UN Special Rapporteur on the Right to Health, Paul Hunt, in light of the Ruggie Principles. It concludes that some guidelines relate directly to the industry's responsibility to respect the right to access to medicines, and form a normative baseline to which firms should be held accountable. It also finds that responsibility for other guidelines may better be ascribed to states than to private actors, based on conceptual and practical considerations. While not discouraging the pharmaceutical industry from making additional

  9. Knowledge grows when shared

    DEFF Research Database (Denmark)

    Elbæk, Mikael Karstensen

    2010-01-01

    Knowledge is one of the few commodities that don’t devalue when used. Actually knowledge grows when shared and the free online access to peer-reviewed scientific publications is a potent ingredient the process of sharing. The sharing of knowledge is facilitated by the Open Access Movement. However...... infrastructure for Open Access was launched in Ghent, Belgium. This project and initiative is facilitating the success of the Open Access Pilot in FP7 as presented earlier in this journal. In this brief article I will present some of the most interesting issues that were discussed during the first session...

  10. Knowledge and Awareness of Cervical Cancer, Human Papillomavirus (HPV), and HPV Vaccine Among HPV-Infected Chinese Women.

    Science.gov (United States)

    Baloch, Zulqarnain; Yasmeen, Nafeesa; Li, Yuanyue; Zhang, Wenhui; Lu, Hongyu; Wu, Xiaomei; Xia, Xueshan; Yang, Shihua

    2017-09-04

    BACKGROUND It is important to understand the knowledge that various groups of a population have about cervical cancer and human papillomavirus (HPV) and their attitudes toward HPV vaccination, as it will ultimately influence their decision-making for or against the acceptability of vaccines and other preventive methods. This study was designed to determine the level of knowledge and awareness about cervical cancer, HPV, and the HPV vaccine among Chinese women in Yunnan province. MATERIAL AND METHODS A survey was conducted in Yunnan province by the Laboratory of Molecular Virology in collaboration with the Yunnan First People's Hospital in Feb 2015. A total of 388 women were recruited and asked to participate in a questionnaire-based interview that collected information related to their awareness and knowledge about: (1) cervical cancer, (2) HPV and HPV vaccine and willingness to have their children receive vaccination, and (3) demographic characteristics. RESULTS A total of 388 HPV-positive women were included; 300/388 (73.3%) were Han, and 88/388 (22.7%) were other ethnicities. Overall, 204/388 (52.6%) of the women were aware of cervical cancer, with a significant difference between Han women and women of other ethnic groups (168/388, 56.0% and 36/88, 40.9%; P=0.015). Overall, 26.5% of the women were aware of the role of HPV in cervical cancer; 29.0% of the Han women and 18.2% of women of other ethnic groups were aware of this role of HPV (P=0.05). The knowledge that HPV infection leads to cervical cancer was higher among Han women (29.0%) compared to women of other ethnicities (18.2%). Knowledge about the HPV vaccine was very low in all ethnic groups, but the Han women were more willing to allow their children to be vaccinated before they become sexually active. A similar difference has also been found in women from various regions. CONCLUSIONS Although level of awareness and knowledge about cervical cancer was moderate, knowledge and awareness of HPV and the HPV

  11. Costing Human Rights and Community Support Interventions as a Part of Universal Access to HIV Treatment and Care in a Southern African Setting

    Science.gov (United States)

    Jones, Louisa; Akugizibwe, Paula; Clayton, Michaela; Amon, Joseph J; Sabin, Miriam Lewis; Bennett, Rod; Stegling, Christine; Baggaley, Rachel; Kahn, James G; Holmes, Charles B; Garg, Navneet; Obermeyer, Carla Makhlouf; Mack, Christina DeFilippo; Williams, Phoebe; Smyth, Caoimhe; Vitoria, Marco; Crowley, Siobhan; Williams, Brian; McClure, Craig; Granich, Reuben; Hirnschall, Gottfried

    2011-01-01

    Expanding access to antiretroviral therapy (ART) has both individual health benefits and potential to decrease HIV incidence. Ensuring access to HIV services is a significant human rights issue and successful programmes require adequate human rights protections and community support. However, the cost of specific human rights and community support interventions for equitable, sustainable and non-discriminatory access to ART are not well described. Human rights and community support interventions were identified using the literature and through consultations with experts. Specific costs were then determined for these health sector interventions. Population and epidemic data were provided through the Statistics South Africa 2009 national mid-year estimates. Costs of scale up of HIV prevention and treatment were taken from recently published estimates. Interventions addressed access to services, minimising stigma and discrimination against people living with HIV, confidentiality, informed consent and counselling quality. Integrated HIV programme interventions included training for counsellors, ‘Know Your Rights’ information desks, outreach campaigns for most at risk populations, and adherence support. Complementary measures included post-service interviews, human rights abuse monitoring, transportation costs, legal assistance, and funding for human rights and community support organisations. Other essential non-health sector interventions were identified but not included in the costing framework. The annual costs for the human rights and community support interventions are United States (US) $63.8 million (US $1.22 per capita), representing 1.5% of total health sector HIV programme costs. Respect for human rights and community engagement can be understood both as an obligation of expanded ART programmes and as a critically important factor in their success. Basic rights-based and community support interventions constitute only a small percentage of overall

  12. Costing human rights and community support interventions as a part of universal access to HIV treatment and care in a Southern African setting.

    Science.gov (United States)

    Jones, Louisa; Akugizibwe, Paula; Clayton, Michaela; Amon, Joseph J; Sabin, Miriam Lewis; Bennett, Rod; Stegling, Christine; Baggaley, Rachel; Kahn, James G; Holmes, Charles B; Garg, Navneet; Obermeyer, Carla Makhlouf; Mack, Christina DeFilippo; Williams, Phoebe; Smyth, Caoimhe; Vitoria, Marco; Crowley, Siobhan; Williams, Brian; McClure, Craig; Granich, Reuben; Hirnschall, Gottfried

    2011-09-01

    Expanding access to antiretroviral therapy (ART) has both individual health benefits and potential to decrease HIV incidence. Ensuring access to HIV services is a significant human rights issue and successful programmes require adequate human rights protections and community support. However, the cost of specific human rights and community support interventions for equitable, sustainable and non-discriminatory access to ART are not well described. Human rights and community support interventions were identified using the literature and through consultations with experts. Specific costs were then determined for these health sector interventions. Population and epidemic data were provided through the Statistics South Africa 2009 national mid-year estimates. Costs of scale up of HIV prevention and treatment were taken from recently published estimates. Interventions addressed access to services, minimising stigma and discrimination against people living with HIV, confidentiality, informed consent and counselling quality. Integrated HIV programme interventions included training for counsellors, 'Know Your Rights' information desks, outreach campaigns for most at risk populations, and adherence support. Complementary measures included post-service interviews, human rights abuse monitoring, transportation costs, legal assistance, and funding for human rights and community support organisations. Other essential non-health sector interventions were identified but not included in the costing framework. The annual costs for the human rights and community support interventions are United States (US) $63.8 million (US $1.22 per capita), representing 1.5% of total health sector HIV programme costs. Respect for human rights and community engagement can be understood both as an obligation of expanded ART programmes and as a critically important factor in their success. Basic rights-based and community support interventions constitute only a small percentage of overall programmes

  13. Planetary Protection Knowledge Gaps for Human Extraterrestrial Missions Workshop Booklet - 2015

    Science.gov (United States)

    Fonda, Mark L.

    2015-01-01

    Although NASA's preparations for the Apollo lunar missions had only a limited time to consider issues associated with the protection of the Moon from biological contamination and the quarantine of the astronauts returning to Earth, they learned many valuable lessons (both positive and negative) in the process. As such, those efforts represent the baseline of planetary protection preparations for sending humans to Mars. Neither the post-Apollo experience or the Shuttle and other follow-on missions of either the US or Russian human spaceflight programs could add many additional insights to that baseline. Current mission designers have had the intervening four decades for their consideration, and in that time there has been much learned about human-associated microbes, about Mars, and about humans in space that has helped prepare us for a broad spectrum of considerations regarding potential biological contamination in human Mars missions and how to control it. This paper will review the approaches used in getting this far, and highlight some implications of this history for the future development of planetary protection provisions for human missions to Mars. The role of NASA and ESA's planetary protection offices, and the aegis of COSPAR have been particularly important in the ongoing process.

  14. Human Rights and/or Market Logic: Neoliberalism, Difficult Knowledge, and the Canadian Museum for Human Rights

    Science.gov (United States)

    Milne, Heather

    2015-01-01

    The Canadian Museum for Human Rights (CMHR) has been plagued by controversy since before its construction even began. Outcries regarding perceived oversights in the museum's programming and objections to the cost of construction, curatorial development, and staffing have erupted frequently in local media. Critical analyses of public responses to…

  15. Human Rights and/or Market Logic: Neoliberalism, Difficult Knowledge, and the Canadian Museum for Human Rights

    Science.gov (United States)

    Milne, Heather

    2015-01-01

    The Canadian Museum for Human Rights (CMHR) has been plagued by controversy since before its construction even began. Outcries regarding perceived oversights in the museum's programming and objections to the cost of construction, curatorial development, and staffing have erupted frequently in local media. Critical analyses of public responses to…

  16. Human papillomavirus (HPV) infection and vaccines: knowledge, attitude and perception among female students at the University of Lagos, Lagos, Nigeria.

    Science.gov (United States)

    Makwe, Christian Chigozie; Anorlu, Rose Ihuoma; Odeyemi, Kofoworola Abimbola

    2012-12-01

    This study sought to determine knowledge of and attitude towards human papillomavirus (HPV) infection, HPV-related diseases and HPV vaccines among female undergraduate students at the University of Lagos. A self-administered questionnaire was administered between May and July 2010, to 368 female students aged 16-29years, who were selected from two faculties of the University of Lagos using two-stage sampling method. Data collected included: socio-demographic characteristics, sexual history, awareness and knowledge of HPV infection, cervical cancer and genital warts, and HPV vaccine; the perceived risk of acquiring genital HPV infection and developing cervical cancer or genital warts, and the willingness to receive an HPV vaccine. Only 64 (17.7%) and 52 (14.4%) of the students had ever heard of HPV infection and HPV vaccines respectively. The median HPV knowledge on a 15-item score was 2. Overall, only 11.1% knew that genital HPV infection can cause cervical cancer. Fourteen (6.9%) of those who were aware of cervical cancer agreed they were at risk of developing the disease. Of the 52 students who had heard of the HPV vaccine, 24 (46.2%) knew it was given for cervical cancer prevention and 30 (57.7%) expressed their willingness to receive the vaccine. The knowledge of and the perceived susceptibility to HPV infection and HPV-related diseases among female students in the University of Lagos were generally low. The need for a well-designed HPV-educational program to bridge the knowledge gap cannot be overemphasized. Copyright © 2012 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

  17. Novel joint TOA/RSSI-based WCE location tracking method without prior knowledge of biological human body tissues.

    Science.gov (United States)

    Ito, Takahiro; Anzai, Daisuke; Jianqing Wang

    2014-01-01

    This paper proposes a novel joint time of arrival (TOA)/received signal strength indicator (RSSI)-based wireless capsule endoscope (WCE) location tracking method without prior knowledge of biological human tissues. Generally, TOA-based localization can achieve much higher localization accuracy than other radio frequency-based localization techniques, whereas wireless signals transmitted from a WCE pass through various kinds of human body tissues, as a result, the propagation velocity inside a human body should be different from one in free space. Because the variation of propagation velocity is mainly affected by the relative permittivity of human body tissues, instead of pre-measurement for the relative permittivity in advance, we simultaneously estimate not only the WCE location but also the relative permittivity information. For this purpose, this paper first derives the relative permittivity estimation model with measured RSSI information. Then, we pay attention to a particle filter algorithm with the TOA-based localization and the RSSI-based relative permittivity estimation. Our computer simulation results demonstrates that the proposed tracking methods with the particle filter can accomplish an excellent localization accuracy of around 2 mm without prior information of the relative permittivity of the human body tissues.

  18. Progressing the state of knowledge on the human influence on hydrological droughts through case studies

    Science.gov (United States)

    Rangecroft, Sally; Van Loon, Anne; Bosman, Marianne; Wanders, Niko; Di Baldassarre, Giuliano; AghaKouchak, Amir

    2017-04-01

    Human activities can have a large influence on changes in the hydrological system and hydrological extremes, more than climate variability and climate change in some cases. However, there are currently only a limited number of studies which aim to quantify the human impact on hydrological droughts. Here we present a synthesis study of existing and new results that aims to summarize and quantify the anthropogenic impact on hydrological drought from case studies and observations. By combining a large number of case studies, we allow conclusions to be drawn about the effects of different human activities. This work suggests ways forward to increase our understanding on how human activities are influencing drought characteristics; invaluable information for water resource management and adaptation. During this project, the impact of different human activities (e.g. water abstraction, reservoir building, urbanisation, etc) on drought frequency, duration and deficit has been calculated in a consistent manner, allowing for an improved understanding to how they have impacted droughts. This consistent methodology is a necessary element for this comparative hydrology exercise, yet we use one which is flexible and applicable to different case study set ups and data availability. The methodology used here depends on available observation data, with three possible approaches: i) paired catchment approach; ii) upstream-downstream comparison; iii) observation modelling framework. The synthesised results of the existing and new case studies cover a number of human activities, hydro-climatic and socio-economic contexts. In particular, we remove the climate dependency in the results by using case studies from multiple climatic regions, including UK, Italy, US, Australia, Mexico and Chile. For groundwater abstraction, it is clear across all the relevant case studies that abstraction activities worsen drought events. This is especially prominent in the deficit volumes, with nearly all

  19. The Knowledge Explosion

    Science.gov (United States)

    Boulding, Kenneth E.

    1970-01-01

    Although human knowledge has expanded rapidly, especially during the scientific era, man is far from the limits of knowledge about the human learning process itself. Greatly increased effort in this area of inquiry is required for survival. (JH)

  20. Can Alice and Bob be random: a study on human playing zero knowledge protocols

    CERN Document Server

    Kulesza, Kamil

    2007-01-01

    The research described in this abstract was initiated by discussions between the author and Giovanni Di Crescenzo in Barcelona in early 2004. It was during Advanced Course on Contemporary Cryptology that Di Crescenzo gave a course on zero knowledge protocols (ZKP), see [1]. After that course we started to play with unorthodox ideas for breaking ZKP, especially one based on graph 3-coloring. It was chosen for investigation because it is being considered as a "benchmark" ZKP, see [2], [3]. At this point we briefly recall such a protocol's description.

  1. A Political Decision Disguised as Legal Argument? Opinion 2/13 and European Union Accession to the European Convention on Human Rights

    DEFF Research Database (Denmark)

    Butler, Graham

    2015-01-01

    of Copenhagen, Denmark. In this interview, carried out in June 2015 for the Utrecht Journal of International and European Law, David Thór Björgvinsson outlined his views to Graham Butler on Opinion 2/13 from the Court of Justice of the European Union on the Union’s accession to the European Convention on Human...

  2. A Political Decision Disguised as Legal Argument? Opinion 2/13 and European Union Accession to the European Convention on Human Rights

    DEFF Research Database (Denmark)

    Butler, Graham

    2015-01-01

    of Copenhagen, Denmark. In this interview, carried out in June 2015 for the Utrecht Journal of International and European Law, David Thór Björgvinsson outlined his views to Graham Butler on Opinion 2/13 from the Court of Justice of the European Union on the Union’s accession to the European Convention on Human...

  3. School Nurses' Knowledge, Attitudes, Perceptions of Role as Opinion Leader, and Professional Practice Regarding Human Papillomavirus Vaccine for Youth

    Science.gov (United States)

    Rosen, Brittany L.; Goodson, Patricia; Thompson, Bruce; Wilson, Kelly L.

    2015-01-01

    Background: Because human papillomavirus (HPV) vaccine rates remain low, we evaluated US school nurses' knowledge, attitudes, perceptions of their role as opinion leaders, and professional practice regarding HPV vaccine, and assessed whether knowledge, attitudes, and perceptions of being an opinion leader influenced their professional…

  4. Development of knowledge based operation system for making product matching with requirement by human sense; Kansei tekigo seihinseizo wo mezashita chiteki opereshon shisumtemu ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Honda, Hiroyuki [Nagoya University, Aichi (Japan). Dept. of Biotechnology

    1999-12-16

    Knowledge based operation system was developed in order to apply the human sense to process operation. Since beverages such as coffee, beer and sake, are seriously evaluated by human sense, those sensory evaluations or data on those chemical composition were subjected to this research. Fuzzy neural network (FNN) ro its hierarchical structure (HFNN) was superior tool for modeling of human sense. With respect to the determination of the chemical composition from desired sensory evaluation, an innovative tool, CF-GA, was newly developed. Using these tools, construction of knowledge based operation system for making the product matching with requirement by human sense became promising. (author)

  5. 科学信息的开放存取与知识的“公有性”信念%The open access of science information and the communism faith of knowledge

    Institute of Scientific and Technical Information of China (English)

    丁大尉; 李正风

    2011-01-01

    “公有性”是科学知识生产的重要制度设计。在知识经济时代,知识的“私有性”和“保密性”在新的知识生产结构中获得了一定的合理性。网络数据库等知识出版模式在加速了知识扩散的同时,带来了科学信息的商业垄断,但这种垄断在本质上不同于对知识合理的“保密”行为,也加剧了数字资源中的“数字鸿沟”。开放存取运动即是科学共同体对于科学信息商业垄断的集体抗争,是对科学知识“公有性”精神气质的认识论回归。%Communism is the important institution design of science knowledge production. In the Knowledge Economy times the privacy and secrecy of knowledge have got some rationality in the new knowledge production structure. The new knowledge publication mode, for example network database, has brought commercial monopoly of scientific informaiton along with rapid scientific diffusion. But this kind of monopoly is different from reasonable secrecy behaviour of knowledge in fact. And it has deepened " digital divide" of digital resource. Open Access is the collective fighting to commercial molopoly of scientific information of scientific community. And it is the epistemic return of communism of scientific knowledge.

  6. Communication and knowledge sharing in human-robot interaction and learning from demonstration.

    Science.gov (United States)

    Koenig, Nathan; Takayama, Leila; Matarić, Maja

    2010-01-01

    Inexpensive personal robots will soon become available to a large portion of the population. Currently, most consumer robots are relatively simple single-purpose machines or toys. In order to be cost effective and thus widely accepted, robots will need to be able to accomplish a wide range of tasks in diverse conditions. Learning these tasks from demonstrations offers a convenient mechanism to customize and train a robot by transferring task related knowledge from a user to a robot. This avoids the time-consuming and complex process of manual programming. The way in which the user interacts with a robot during a demonstration plays a vital role in terms of how effectively and accurately the user is able to provide a demonstration. Teaching through demonstrations is a social activity, one that requires bidirectional communication between a teacher and a student. The work described in this paper studies how the user's visual observation of the robot and the robot's auditory cues affect the user's ability to teach the robot in a social setting. Results show that auditory cues provide important knowledge about the robot's internal state, while visual observation of a robot can hinder an instructor due to incorrect mental models of the robot and distractions from the robot's movements.

  7. The effects of type of knowledge upon human problem solving in a process control task

    Science.gov (United States)

    Morris, N. M.; Rouse, W. B.

    1985-01-01

    The question of what the operator of a dynamic system needs to know was investigated in an experiment using PLANT, a simulation of a generic dynamic production process. Knowledge of PLANT was manipulated via different types of instruction, so that four different groups were created: (1) minimal instructions only; (2) minimal instructions and guidelines for operation (procedures); (3) minimal instructions and dynamic relationships (principles); and (4) minimal instructions, and procedures, and principles. Subjects controlled PLANT in a variety of situations which required maintaining production while also diagnosing familiar and unfamiliar failures. Despite the fact that these manipulations resulted in differences in subjects' Knowledge, as assessed via a written test at the end of the experiment, instructions had no effect upon achievement of the primary goal of production, or upon subjects' ability to diagnose unfamiliar failures. However, those groups receiving procedures controlled the system in a more stable manner. Possible reasons for the failure to find an effect of principles are presented, and the implications of these results for operator training and aiding are discussed.

  8. Knowledge of young Polish women of human papillomavirus (HPV infection and cervical cancer prevention

    Directory of Open Access Journals (Sweden)

    Martyna Biała

    2015-03-01

    Full Text Available Introduction. HPV infection is the most frequent sexually transmitted disease and a major epidemiological problem in the world. HPV 16 and HPV 18 are responsible for over 70.0% cases of cervical cancer. The aim of this study was to evaluate the knowledge of young women concerning HPV infection as well as possibilities of cervical cancer prevention. Moreover, the study had to determine which groups of young women especially required educational campaigns. Material and methods. The questionnaire survey was carried out among 126 young Polish women aged 18–35. The results were statistically analyzed. Results. The survey found that 41.3% women had heard about HPV before interview. Nearly 38.5% of women correctly indicated the occurrence of cancer which is associated with HPV infection. About 23.0% of women received a vaccination against HPV, only 19.2% of women correctly identified who should be subjected to vaccination. The best knowledge about cervical cancer and disease prevention was manifested among female university graduates and groups living in urban areas. Those women also more often underwent cytological screening. Conclusions. Educational campaigns should particularly include group of women living in the rural areas and women with primary and secondary education.

  9. Harnessing the Risk-Related Data Supply Chain: An Information Architecture Approach to Enriching Human System Research and Operations Knowledge

    Science.gov (United States)

    Buquo, Lynn; Johnson-Throop, Kathy

    2010-01-01

    NASA's Human Research Program (HRP) and Space Life Sciences Directorate (SLSD), not unlike many NASA organizations today, struggle with the inherent inefficiencies caused by dependencies on heterogeneous data systems and silos of data and information spread across decentralized discipline domains. The capture of operational and research-based data/information (both in-flight and ground-based) in disparate IT systems impedes the extent to which that data/information can be efficiently and securely shared, analyzed, and enriched into knowledge that directly and more rapidly supports HRP's research-focused human system risk mitigation efforts and SLSD s operationally oriented risk management efforts. As a result, an integrated effort is underway to more fully understand and document how specific sets of risk-related data/information are generated and used and in what IT systems that data/information currently resides. By mapping the risk-related data flow from raw data to useable information and knowledge (think of it as the data supply chain), HRP and SLSD are building an information architecture plan to leverage their existing, shared IT infrastructure. In addition, it is important to create a centralized structured tool to represent risks including attributes such as likelihood, consequence, contributing factors, and the evidence supporting the information in all these fields. Representing the risks in this way enables reasoning about the risks, e.g. revisiting a risk assessment when a mitigation strategy is unavailable, updating a risk assessment when new information becomes available, etc. Such a system also provides a concise way to communicate the risks both within the organization as well as with collaborators. Understanding and, hence, harnessing the human system risk-related data supply chain enhances both organizations' abilities to securely collect, integrate, and share data assets that improve human system research and operations.

  10. Cervical Cancer Prevention in Malaysia: Knowledge and Attitude of Undergraduate Pharmacy Students Towards Human Papillomavirus Infection, Screening and Vaccination in Malaysia.

    Science.gov (United States)

    Maharajan, Mari Kannan; Rajiah, Kingston; Sze Fang, Kelly Num; Lui, Lai Yun

    2017-03-01

    This study was conducted to evaluate knowledge of undergraduate pharmacy students about human papillomavirus infection and their attitude towards its prevention. A cross-sectional survey was conducted in 270 undergraduate pharmacy students using a validated questionnaire to assess knowledge about human papillomavirus infection and cervical cancer and their attitudes towards human papillomavirus vaccines. Eighty-one percent of the respondents knew that human papillomavirus is a cause of cervical cancer, and 87.8 % knew that this infection is preventable. The gender of the respondents showed the strongest correlations with human papillomavirus knowledge. There were no significant correlations between the ethnic group of the respondents and their human papillomavirus-related knowledge. Higher perceptions of risk were associated with relationship status, and respondents who were in a relationship showed greater interest in vaccinating themselves; relationship status emerged as a unique predictor. The results indicated a moderately high level of knowledge and positive attitude towards human papillomavirus vaccination with few disagreements. The results of this study will help to develop and plan appropriate education campaigns for pharmacy students that aim to reduce human papillomavirus infection and, consequently, the incidence of and mortality caused by cervical cancer in Malaysia.

  11. Quality and Knowledge Content in Music Activities in Preschool: The Impact of Human Materiality Combinations

    Science.gov (United States)

    Zimmerman Nilsson, Marie-Helene; Holmberg, Kristina

    2017-01-01

    Traditionally, pedagogical research has been child centered, where materialities often have been considered as objects and tools. However, in recent posthuman research, attempts have been made to consider human materiality combinations to have impact on pedagogical activities in preschool, but to a large extent music as an issue has been…

  12. Human vs. Computer Diagnosis of Students' Natural Selection Knowledge: Testing the Efficacy of Text Analytic Software

    Science.gov (United States)

    Nehm, Ross H.; Haertig, Hendrik

    2012-01-01

    Our study examines the efficacy of Computer Assisted Scoring (CAS) of open-response text relative to expert human scoring within the complex domain of evolutionary biology. Specifically, we explored whether CAS can diagnose the explanatory elements (or Key Concepts) that comprise undergraduate students' explanatory models of natural selection with…

  13. An Analysis of Knowledge Production and Organizational Change within Four Approaches to Human Resource Development.

    Science.gov (United States)

    Vincere, Thomas J.

    1994-01-01

    Analyzes four models for work place learning, focusing on their respective learning design models. Shows how work place education affects issues of deskilling, the objectification of the worker as human capital, and the reproduction of capitalist ideology and inequalities of gender, race, ethnicity, and class. Calls for new directions for adult…

  14. Quality and Knowledge Content in Music Activities in Preschool: The Impact of Human Materiality Combinations

    Science.gov (United States)

    Zimmerman Nilsson, Marie-Helene; Holmberg, Kristina

    2017-01-01

    Traditionally, pedagogical research has been child centered, where materialities often have been considered as objects and tools. However, in recent posthuman research, attempts have been made to consider human materiality combinations to have impact on pedagogical activities in preschool, but to a large extent music as an issue has been…

  15. Governing Difficult Knowledge: The Canadian Museum for Human Rights and Its Publics

    Science.gov (United States)

    Sharma, Karen

    2015-01-01

    This article examines how the Canadian Museum for Human Rights (CMHR) comes to invoke, realize, and mediate museum publics. The author writes that she is interested in how the museum's architecture, rhetoric, and governance framings imagine, and engage with the public. As Canada's newest national museum and the first to be built outside of the…

  16. Mapping of suitable zones for manual drilling as a possible solution to increase access to drinking water in Africa through integration of systematized GIS data and local knowledge

    Science.gov (United States)

    Fussi, Fabio; Alvino, Roberta; Caruba, Massimo; Galimberti, Luca; Marzan, Ignacio; Tarrason y Cerda', David; Sabatini, Daniela

    2013-04-01

    In several African countries water supply is still largely a huge problem. In order to achieve MDG for water supply, UNICEF is promoting manual drilling in Africa. Manual drilling refers to those techniques of drilling boreholes for groundwater exploitation using human or animal power (not mechanized equipment). These techniques are well known in countries with large alluvial deposits (India, Nepal, Bangladesh, etc). They are cheaper than mechanized boreholes, easy to implement as the equipment is locally done, able to provide clean water if correctly applied. But manual drilling is feasible only where suitable hydrogeological conditions are met: - the shallow geological layers are not too hard (soft sediments or rocks having limited resistance) and have good permeability; - the depth where it is possible to find exploitable water is limited (in this study we assumed no deeper than 25 m). For this reason mapping of suitable zone for manual drilling has been the first step in UNICEF program already completed in 15 countries. this paper explains the general methodology for the identification of suitable zones at country level The methodology is based in the integration of different information (maps, reports, database) already existing in each country, together with interview of local technicians with direct experience in various regions and limited direct field data collection. General suitability for manual drilling (although adapted to specific condition in each country) is based on the combination of three main parameters: the geological suitability, the suitability according to water depth and the morphological suitability: - Geological suitability is related to the hardness and permeability of the shallow layers of rock formations. It has been obtained through a GIS procedure of simplification and reclassification of geological maps, estimating hardness and permeability of main rock and overlaying weathered layer on the basis of stratigraphic borehole logs

  17. Echinococcus granulosus sensu lato genotypes infecting humans--review of current knowledge.

    Science.gov (United States)

    Alvarez Rojas, Cristian A; Romig, Thomas; Lightowlers, Marshall W

    2014-01-01

    Genetic variability in the species group Echinococcus granulosus sensu lato is well recognised as affecting intermediate host susceptibility and other biological features of the parasites. Molecular methods have allowed discrimination of different genotypes (G1-10 and the 'lion strain'), some of which are now considered separate species. An accumulation of genotypic analyses undertaken on parasite isolates from human cases of cystic echinococcosis provides the basis upon which an assessment is made here of the relative contribution of the different genotypes to human disease. The allocation of samples to G-numbers becomes increasingly difficult, because much more variability than previously recognised exists in the genotypic clusters G1-3 (=E. granulosus sensu stricto) and G6-10 (Echinococcus canadensis). To accommodate the heterogeneous criteria used for genotyping in the literature, we restrict ourselves to differentiate between E. granulosus sensu stricto (G1-3), Echinococcus equinus (G4), Echinococcus ortleppi (G5) and E. canadensis (G6-7, G8, G10). The genotype G1 is responsible for the great majority of human cystic echinococcosis worldwide (88.44%), has the most cosmopolitan distribution and is often associated with transmission via sheep as intermediate hosts. The closely related genotypes G6 and G7 cause a significant number of human infections (11.07%). The genotype G6 was found to be responsible for 7.34% of infections worldwide. This strain is known from Africa and Asia, where it is transmitted mainly by camels (and goats), and South America, where it appears to be mainly transmitted by goats. The G7 genotype has been responsible for 3.73% of human cases of cystic echinococcosis in eastern European countries, where the parasite is transmitted by pigs. Some of the samples (11) could not be identified with a single specific genotype belonging to E. canadensis (G6/10). Rare cases of human cystic echinococcosis have been identified as having been caused by

  18. Patient Knowledge on Malaria Symptoms Is a Key to Promoting Universal Access of Patients to Effective Malaria Treatment in Palawan, the Philippines

    OpenAIRE

    Emilie Louise Akiko Matsumoto-Takahashi; Pilarita Tongol-Rivera; Villacorte, Elena A; Ray U Angluben; Masamine Jimba; Shigeyuki Kano

    2015-01-01

    Introduction Palawan, where health care facilities are still limited, is one of the most malaria endemic provinces in the Philippines. Since 1999, microscopists (community health workers) have been trained in malaria diagnosis and feasibility of early diagnosis and treatments have been enhanced throughout the province. To accelerate the universal access of malaria patients to diagnostic testing in Palawan, positive health seeking behavior should be encouraged when malaria infection is suspect...

  19. An evaluation of EMBASE within the NHS: findings of the Database Access Project working partnership to extend the knowledge base of healthcare.

    Science.gov (United States)

    Hallam, E; Plaice, C

    1999-09-01

    An earlier article in the Innovations on the Internet Series introduced the Database Access Project (DAPs) at Southmead Health Services NHS Trust, which piloted the introduction and use of EMBASE via the Internet and NHSnet. This follow-up article assesses the results of the Project, and reports on its findings. In particular, it considers the usefulness of EMBASE in terms of coverage and content for different groups of NHS users and aspects of take-up in terms of access arrangements and patterns of usage. It also considers the likely impact on the library and information service in terms of providing training and user support and meeting related demands, for example the acquisition of full-text articles as a result of increased levels of searching. The value of retaining access to EMBASE was recognized by the majority of those who participated in the Project, despite its acknowledged overlap with other databases. The coverage of the database was identified as being relevant by a majority of users; both its expanded European coverage and its coverage of drug-related and mental health literature were identified as important aspects. The project identified a clear preference for remote access to the database, although there was still a need to visit the library for retrieval of full text. Lack of time both for training and for actual database use, and lack of confidence in applying search skills and in appraising research were identified as key challenges to database searching. The authors highlight the special role of information professionals in providing training and support for NHS professionals in the acquisition of search skills and critical appraisal skills in order to encourage effective database use.

  20. How concepts are encoded in the human brain: A modality independent, category-based cortical organization of semantic knowledge.

    Science.gov (United States)

    Handjaras, Giacomo; Ricciardi, Emiliano; Leo, Andrea; Lenci, Alessandro; Cecchetti, Luca; Cosottini, Mirco; Marotta, Giovanna; Pietrini, Pietro

    2016-07-15

    How conceptual knowledge is represented in the human brain remains to be determined. To address the differential role of low-level sensory-based and high-level abstract features in semantic processing, we combined behavioral studies of linguistic production and brain activity measures by functional magnetic resonance imaging in sighted and congenitally blind individuals while they performed a property-generation task with concrete nouns from eight categories, presented through visual and/or auditory modalities. Patterns of neural activity within a large semantic cortical network that comprised parahippocampal, lateral occipital, temporo-parieto-occipital and inferior parietal cortices correlated with linguistic production and were independent both from the modality of stimulus presentation (either visual or auditory) and the (lack of) visual experience. In contrast, selected modality-dependent differences were observed only when the analysis was limited to the individual regions within the semantic cortical network. We conclude that conceptual knowledge in the human brain relies on a distributed, modality-independent cortical representation that integrates the partial category and modality specific information retained at a regional level.

  1. Latest research results on the effects of nanomaterials on humans and the environment: DaNa - Knowledge Base Nanomaterials

    Science.gov (United States)

    Marquardt, C.; Kühnel, D.; Richter, V.; Krug, H. F.; Mathes, B.; Steinbach, C.; Nau, K.

    2013-04-01

    Nanotechnology is considered one of the key technologies of the 21st century. The success of this fascinating technology is based on its versatility. It will bring about fundamental changes of basic research as well as of many sectors of industry and also of daily life from electronics to the health care system. However, consumers often miss reliable and understandable information on nanomaterials and all aspects of this versatile technology. A huge body of data on the potential hazards of nanoobjects towards human and environmental health already exists, but is either not easily accessible for a broad audience or presented unprocessable for nonexperts. But risk communication is an essential and thus integral component of risk management. For that purpose, the DaNa-Project aims at filling this gap by collecting and evaluating scientific results in an interdisciplinary approach with scientists from different research areas, such as human and environmental toxicology, biology, physics, chemistry, and sociology. Research findings from the field of human and environmental nanotoxicology are being prepared and presented together with material properties and possible applications for interested laymen and stakeholders. For the evaluation of literature a "Literature Criteria Checklist" has been developed as well as a Standard Operation Procedure template (SOP) based on careful scientific practice.

  2. Bromo volcano area as human-environment system: interaction of volcanic eruption, local knowledge, risk perception and adaptation strategy

    Science.gov (United States)

    Bachri, Syamsul; Stötter, Johann; Sartohadi, Junun

    2013-04-01

    People in the Bromo area (located within Tengger Caldera) have learn to live with the threat of volcanic hazard since this volcano is categorized as an active volcano in Indonesia. During 2010, the eruption intensity increased yielding heavy ash fall and glowing rock fragments. A significant risk is also presented by mass movement which reaches areas up to 25 km from the crater. As a result of the 2010 eruption, 12 houses were destroyed, 25 houses collapsed and there were severe also effects on agriculture and the livestock sector. This paper focuses on understanding the interaction of Bromo volcanic eruption processes and their social responses. The specific aims are to 1) identify the 2010 eruption of Bromo 2) examine the human-volcano relationship within Bromo area in general, and 3) investigate the local knowledge related to hazard, risk perception and their adaptation strategies in specific. In-depth interviews with 33 informants from four districts nearest to the crater included local people and authorities were carried out. The survey focused on farmers, key persons (dukun), students and teachers in order to understand how people respond to Bromo eruption. The results show that the eruption in 2010 was unusual as it took continued for nine months, the longest period in Bromo history. The type of eruption was phreatomagmatic producing material dominated by ash to fine sand. This kind of sediment typically belongs to Tengger mountain eruptions which had produced vast explosions in the past. Furthermore, two years after the eruption, the interviewed people explained that local knowledge and their experiences with volcanic activity do not influence their risk perception. Dealing with this eruption, people in the Bromo area applied 'lumbung desa' (traditional saving systems) and mutual aid activity for surviving the volcanic eruption. Keywords: Human-environment system, local knowledge, risk perception, adaptation strategies, Bromo Volcano Indonesia

  3. Parasites of importance for human health in Nigerian dogs: high prevalence and limited knowledge of pet owners

    Directory of Open Access Journals (Sweden)

    Heukelbach Jorg

    2008-12-01

    Full Text Available Abstract Background Dogs are the most common pet animals worldwide. They may harbour a wide range of parasites with zoonotic potential, thus causing a health risk to humans. In Nigeria, epidemiological knowledge on these parasites is limited. Methods In a community-based study, we examined 396 dogs in urban and rural areas of Ilorin (Kwara State, Central Nigeria for ectoparasites and intestinal helminths. In addition, a questionnaire regarding knowledge and practices was applied to pet owners. Results Nine ectoparasite species belonging to four taxa and six intestinal helminth species were identified: fleas (Ctenocephalides canis, Pulex irritans, Tunga penetrans, mites (Demodex canis, Otodectes sp., Sarcoptes scabiei var. canis, ticks (Rhipicephalus sanguineus, Ixodes sp., and lice (Trichodectes canis; and Toxocara canis, Ancylostoma sp., Trichuris vulpis, Dipylidium caninum, Taenidae and Strongyloides sp. Overall prevalence of ectoparasites was 60.4% and of intestinal helminths 68.4%. The occurrence of C. canis, R. sanguineus, T. canis, Ancylostoma sp. and T. vulpis was most common (prevalence 14.4% to 41.7%. Prevalence patterns in helminths were age-dependent, with T. canis showing a decreasing prevalence with age of host, and a reverse trend in other parasite species. Knowledge regarding zoonoses was very limited and the diseases not considered a major health problem. Treatment with antiparasitic drugs was more frequent in urban areas. Conclusion Parasites of importance for human health were highly prevalent in Nigerian dogs. Interventions should include health education provided to dog owners and the establishment of a program focusing on zoonotic diseases.

  4. Physiological Reactivity to Psychological Stress in Human Pregnancy: Current Knowledge and Future Directions

    Science.gov (United States)

    Christian, Lisa M.

    2012-01-01

    Cardiovascular and neuroendocrine reactivity to acute stress are important predictors of health outcomes in non-pregnant populations. Greater magnitude and duration of physiological responses have been associated with increased risk of hypertensive disorders and diabetes, greater susceptibility to infectious illnesses, suppression of cell-mediated immunity as well as risk for depression and anxiety disorders. Stress reactivity during pregnancy has unique implications for maternal health, birth outcomes, and fetal development. However, as compared to the larger literature, our understanding of the predictors and consequences of exaggerated stress reactivity in pregnancy is limited. This paper reviews the current state of this literature with an emphasis on gaps in knowledge and future directions. PMID:22800930

  5. Quality management as knowledge sharing: experiences of the Napa County Health and Human Services Agency.

    Science.gov (United States)

    Harrison, Lindsay

    2012-01-01

    Lacking a coordinated effort in utilizing data and tracking program outcomes, one agency developed a Quality Management (QM) division to facilitate and manage more effective data use. To support this process, the agency sought to develop a collective, agency-wide understanding and investment in improving and measuring client outcomes. Similarly, the agency also focused efforts on creating a culture of transparency and accountability, with goals of improving service, increasing agency integrity, meeting regulatory compliance, and engaging in effective risk management. Operationalizing the QM initiative involved developing procedures, systems, and guidelines that would facilitate the generation of reliable and accurate data that could be used to inform program change and decision-making. This case study describes this agency's experience in successfully creating and implementing a QM initiative aimed at engaging in greater knowledge sharing.

  6. The effects of level of knowledge upon human problem solving in a process control task

    Science.gov (United States)

    Morris, N. M.; Rouse, W. B.

    1983-01-01

    The effect of knowledge of a system on the performance of the operator has been investigated using PLANT, a generic simulation of a process. Four sets of written instructions representing the what, how, and why of system control were utilized by groups of subjects who controlled PLANT in a variety of familiar and unfamiliar situations. Written test results at the end of the experiments showed that the instructions had no effect on the primary goal of production, but those groups receiving guidelines for operation (the how) controlled the system in a more stable manner. Principles (the why) had no apparent effect on the subjects' performance. There was no difference between groups in diagnosing unfamiliar events.

  7. Knowledge, Ethics and Choices: Theorizing the Functional Matrix of Literature as a Humanities Discipline

    OpenAIRE

    2016-01-01

    One may inaugurate the contemporary post-theory era with thinking beyond the theoretical aspects of literature. Or, in other words, it may facilitate a revision of literary theories in terms of exploring their functionality. But, a complex question involved here is, what may be its implications. How may it affect various disciplines especially the Humanities which are, unlike Sciences, deal with the abstract issues like truth, reality, ethicality, justice and many more like that? With these q...

  8. Knowledge and awareness of human papillomavirus (HPV), cervical cancer and HPV vaccine among women in two distinct Nepali communities.

    Science.gov (United States)

    Johnson, Derek Christopher; Bhatta, Madhav Prasad; Gurung, Santosh; Aryal, Shilu; Lhaki, Pema; Shrestha, Sadeep

    2014-01-01

    This study assessed human papillomavirus (HPV), cervical cancer, and HPV vaccine knowledge and awareness among women in two sub-populations in Nepal - Khokana, a traditional Newari village in the Lalitpur District about eight kilometers south of Kathmandu, and Sanphebagar, a village development committee within Achham District in rural Far-Western Nepal. Study participants were recruited during health camps conducted by Nepal Fertility Care Center, a Nepali non-governmental organization. Experienced staff administered a Nepali language survey instrument that included questions on socio-demographics, reproductive health and knowledge on HPV, cervical cancer, and the HPV vaccine. Of the 749 participants, 387 (51.7%) were from Khokana and 362 (48.3%) were from Sanphebagar. Overall, 53.3% (n=372) of women were aware of cervical cancer with a significant difference between Khokana and Sanphebagar (63.3% vs 43.0%; p=0.001). Overall, 15.4% (n=107) of women had heard of HPV and 32% (n=34) of these women reported having heard of the HPV vaccine. If freely available, 77.5% of the women reported willingness to have their children vaccinated against HPV. Factors associated with cervical cancer awareness included knowledge of HPV (Khokana: Odds Ratio (OR)=24.5; (95% Confidence Interval (CI): 3.1-190.2, Sanphebagar: OR=14.8; 95% CI: 3.7-58.4)) and sexually transmitted infections (Khokana: OR=6.18; 95% CI: 3.1-12.4; Sanphebagar: OR=17.0; 95% CI: 7.3- 39.7) among other risk factors. Knowledge and awareness of HPV, cervical cancer, and the HPV vaccine remains low among women in Khokana and Sanphebagar. Acceptance of a freely available HPV vaccine for children was high, indicating potentially high uptake rates in these communities.

  9. Recent advances and remaining gaps in our knowledge of associations between gut microbiota and human health

    Institute of Scientific and Technical Information of China (English)

    Volker Mai; Peter V Draganov

    2009-01-01

    The complex gut microbial flora harbored by individuals (microbiota) has long been proposed to contribute to intestinal health as well as disease. Pre- and probiotic products aimed at improving health by modifying microbiota composition have already become widely available and acceptance of these products appears to be on the rise. However, although required for the development of effective microbiota based interventions, our basic understanding of microbiota variation on a population level and its dynamics within individuals is still rudimentary. Powerful new parallel sequence technologies combined with other efficient molecular microbiota analysis methods now allow for comprehensive analysis of microbiota composition in large human populations. Recent findings in the field strongly suggest that microbiota contributes to the development of obesity, atopic diseases, inflammatory bowel diseases and intestinal cancers. Through the ongoing National Institutes of Health Roadmap 'Human of the world, a large coordinated effort is currently underway to study how microbiota can impact human health. Translating findings from these studies into effective interventions that can improve health,possibly personalized based on an individuals existing microbiota, will be the task for the next decade(s).

  10. 荆门市城市居民精神卫生知识掌握及获取途径的调查分析%Investigation and analysis in urban residents' mental health knowledge and access to it

    Institute of Scientific and Technical Information of China (English)

    齐玉梅; 王生锋; 王桂华

    2010-01-01

    Objective To probe into urban residents' mental health knowledge awareness in Jingmen city. Methods By means of self-compiled questionnaires, 563 community residents were surveyed about their mental health knowledge and access to it. Results For mental health- care knowledge, community residents scored a total of (42.52±8.79), among which, (15.34±3.25) points for relevant causes,(12.23±4.89) points for corresponding symptoms, and (14.92±4.26) for health behavior. Such aspects would affect a resident's awareness of mental health knowledge as the resident's education background,marriage and chronic diseases. Radio and television (48.3%), newspapers and magazines (41.4%), hospital expert advice (39.8%), and community medical services (36.1% ) were considered the better access to mental health knowledge. Conclusions Residents had considerably inadequate knowledge of mental health. Therefore, a variety of health- care education activities should be carried out to improve residents'mental health knowledge.%目的 了解荆门市城市居民精神卫生保健知识认知现状.方法 自编调查问卷对荆门市563名社区居民进行问卷调查,以了解其精神卫生知识认知状况及获取途径.结果 荆门市社区居民精神卫生保健知识总分为(42.52±8.79)分,其中相关病因(15.34±3.25)分,相应症状(12.23±4.89)分,保健行为(14.92±4.26)分,文化程度、婚姻状况和慢性病是荆门市社区居民精神卫生保健知识认知的影响因素.社区居民认为较好的健康教育途径是广播电视(48.3%)、报刊杂志(41.4%)、医院专家咨询(39.8%)和社区卫生服务机构(36.1%).结论 社区居民精神卫生保健知识认知率较低,应开展多种形式的健康教育,提高社区居民的精神卫生知识.

  11. Evaluating a Human Rights-Based Advocacy Approach to Expanding Access to Pain Medicines and Palliative Care: Global Advocacy and Case Studies from India, Kenya, and Ukraine.

    Science.gov (United States)

    Lohman, Diederik; Amon, Joseph J

    2015-12-10

    Palliative care has been defined as care that is person-centered and attentive to physical symptoms and psychological, social, and existential distress in patients with severe or life-threatening illness. The identification of access to palliative care and pain treatment as a human rights issue first emerged among palliative care advocates, physicians, and lawyers in the 1990s, with a basis in the right to health and the right to be free from cruel, inhuman, and degrading treatment. Using a case study approach, we evaluate the results of a human rights-based advocacy approach on access to pain medicine and palliative care in India, Kenya, and Ukraine. In each country, human rights advocacy helped raise awareness of the issue, identify structural barriers to care, define government obligations, and contribute to the reform of laws, policies, and practices impeding the availability of palliative care services. In addition, advocacy efforts stimulated civil society engagement and high-level political leadership that fostered the implementation of human rights-based palliative care programs. Globally, access to palliative care was increasingly recognized by human rights bodies and within global health and drug policy organizations as a government obligation central to the right to health.

  12. Contextual Uncertainties, Human Mobility, and Perceived Food Environment: The Uncertain Geographic Context Problem in Food Access Research.

    Science.gov (United States)

    Chen, Xiang; Kwan, Mei-Po

    2015-09-01

    We examined the uncertainty of the contextual influences on food access through an analytic framework of the uncertain geographic context problem (UGCoP). We first examined the compounding effects of two kinds of spatiotemporal uncertainties on people's everyday efforts to procure food and then outlined three key dimensions (food access in real time, temporality of the food environment, and perceived nutrition environment) in which research on food access must improve to better represent the contributing environmental influences that operate at the individual level. Guidelines to address the UGCoP in future food access research are provided to account for the multidimensional influences of the food environment on dietary behaviors.

  13. Efficacy of constitutional support to enhance access to essential medicines as a human right to health in the Eastern Mediterranean region.

    Science.gov (United States)

    Elsayed, L M

    2012-01-01

    Access to essential medicines is an element of the international agreements on the human right to health. This review summarizes the current situation concerning access to medicines in the Eastern Mediterranean Region (EMR) by examining the policies, constitutional provisions and other legal instruments of the Member States. The constitutions of 18 out of 22 EMR countries enshrine health as a human right (8 countries have a duty statement, 5 have a programmatic statement and 5 specify entitlement); only 4 EMR countries do not enshrine health as a human right in a clause in their constitution. More than half the countries (i.e. 12) have an official national medicines policy, 4 have a draft policy and 6 have no national medicines policy. A total of 11 countries operate an essential medicines list. Realization of this right to health necessitates that duty bearers take all necessary legislative measures to respect, protect and fulfil this right.

  14. Are Clark's Nutcrackers (Nucifraga Columbiana Able to Discriminate Knowledge States of Human Experimenters during an Object-Choice Task?

    Directory of Open Access Journals (Sweden)

    Dawson Clary

    2013-07-01

    Full Text Available Corvids and primates have been shown to possess similar cognitive adaptations, yet these animals are seldom tested using similar procedures. Object-choice tasks, which have commonly been used to test whether an animal is able to infer the mental state of a human experimenter based on a gestural cue, provide one potential means of testing these animals using a similar paradigm. The current study used an object-choice task to examine whether the corvid, Clark's nutcracker (Nucifraga columbiana, is able to use a cognitive strategy to discriminate between the knowledge states of two human experimenters. One experimenter was informed, and the other uninformed, as to the location of a food reward hidden inside one of two opaque containers. During the Uninformed Gesture condition, the nutcrackers were given probe tests during which only the person performing as the uninformed experimenter provided a gesture. Thus, the nutcrackers could not use the experimenter's gesture to reliably find the food. During the Gesture Conflict condition, the nutcrackers were presented with a cue conflict. During probe tests, both the informed and the uninformed experimenter gestured to separate containers. Thus, to find the food the nutcrackers had to use the gesture from the informed experimenter and refrain from using the gesture of the uninformed experimenter. Our results showed that when the uninformed experimenter's gesture was presented alone, the birds continued to follow the gesture even though it was not consistently predictive of the food's location. However, when provided with two conflicting gestures, as a group the nutcrackers responded to the gesture of the informed experimenter at above chance levels. These results suggest that the birds had learned that the gesture was informative, perhaps by associative learning, yet when this mechanism was not reliable the nutcrackers were able to use either the human experimenters' presence/absence during the baiting

  15. Access Nets: Modeling Access to Physical Spaces

    Science.gov (United States)

    Frohardt, Robert; Chang, Bor-Yuh Evan; Sankaranarayanan, Sriram

    Electronic, software-managed mechanisms using, for example, radio-frequency identification (RFID) cards, enable great flexibility in specifying access control policies to physical spaces. For example, access rights may vary based on time of day or could differ in normal versus emergency situations. With such fine-grained control, understanding and reasoning about what a policy permits becomes surprisingly difficult requiring knowledge of permission levels, spatial layout, and time. In this paper, we present a formal modeling framework, called AccessNets, suitable for describing a combination of access permissions, physical spaces, and temporal constraints. Furthermore, we provide evidence that model checking techniques are effective in reasoning about physical access control policies. We describe our results from a tool that uses reachability analysis to validate security policies.

  16. Scientific publishing online,and the question of open access. Why such a long delay?

    Directory of Open Access Journals (Sweden)

    Christine Kosmopoulos

    2005-05-01

    Full Text Available In October of 2003 in Berlin, twenty directors of European research institutes (the CNRS, INSERM, the Max Plank Institute, ratified a Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities, in which they committed themselves to supporting all initiatives based on the paradigm of free access on the Internet. In February 2005, the Berlin 3 Conference, held in Southampton, encouraged researchers to publish in journals offering free access. But while this model is being in...

  17. On the trails of markers and proxies: the socio-cognitive technologies of human movement, knowledge assemblage, and their relevance to the etiology of nasopharyngeal carcinoma

    Institute of Scientific and Technical Information of China (English)

    David Turnbull

    2011-01-01

    Bacteria, pigs, rats, pots, plants, words, bones, stones, earrings, diseases, and genetic indicators of all varieties are markers and proxies for the complexity of interweaving trails and stories integral to understanding human movement and knowledge assemblage in Southeast Asia and around the world.Understanding human movement and knowledge assemblage is central to comprehending the genetic basis of disease, especially of a cancer like nasopharyngeal carcinoma. The problem is that the markers and trails, taken in isolation, do not all tell the same story. Human movement and knowledge assemblage are in constant interaction in an adaptive process of co-production with genes, terrain, climate, sea level changes, kinship relations, diet, materials, food and transport technologies, social and cognitive technologies, and knowledge strategies and transmission. Nasopharyngeal carcinoma is the outcome of an adaptive process involving physical, social, and genetic components.

  18. Traditional treatment of human and animal salmonelloses in Southern Benin: Knowledge of farmers and traditherapists

    Directory of Open Access Journals (Sweden)

    T. V. Dougnon

    2017-06-01

    Full Text Available Aim: This study aimed to report medicinal plants that are likely to be used in the control of salmonellosis. Materials and Methods: A cross-sectional study was conducted in Southern Benin. Semi-structured questionnaires were administered to 150 farmers and 100 traditional therapists in seven high municipalities. This step helped to collect plants that are used in the treatment of animal salmonellosis and typhoid fever in human. Results: The results revealed a low level of use of medicinal plants among breeders who prefer antibiotics such as oxytetracycline (53.55%, tylosine + sulfadimerazine (15.30%, and alphaceryl (19.13%. However, plants such as Moringa oleifera (leaves, Carica papaya (leaves and seeds, and Vernonia amygdalina (leaves were mostly used by some farmers. From traditional therapists, 57 plant species of 32 families were identified as typhoid fever cures; among which Leguminosae, Asteraceae, and Euphorbiaceae were predominant. Persea americana (22.72%, V. amygdalina (7.57%, and Corchorus olitorius (7.57% were the most cited by traditherapists for the treatment of typhoid fever in human. Conclusion: This study provides a database for further studies on the in vitro and in vivo efficacy of Benin plant species on Salmonella spp. These evaluations will guarantee the availability of new therapeutic solutions for populations.

  19. Human resources needs for universal access to antiretroviral therapy in South Africa: a time and motion study

    NARCIS (Netherlands)

    Hontelez, J.A.C.; Newell, M.L.; Bland, R.M.; Munnelly, K.; Lessells, R.J.; Barnighausen, T.

    2012-01-01

    ABSTRACT: BACKGROUND: Although access to life-saving treatment for patients infected with HIV patients in South Africa has improved substantially since 2004, treating all eligible patients (universal access) remains elusive. As the prices of antiretroviral drugs have dropped over the past years, ava

  20. Human resources needs for universal access to antiretroviral therapy in South Africa: A time and motion study

    NARCIS (Netherlands)

    J.A.C. Hontelez (Jan A.C.); M.L. Newell (Marie Louise); R.M. Bland (Ruth); K. Munnelly (Kristen); R.J. Lessells (Richard ); T. Bärnighausen (Till)

    2012-01-01

    textabstractBackground: Although access to life-saving treatment for patients infected with HIV in South Africa has improved substantially since 2004, treating all eligible patients (universal access) remains elusive. As the prices of antiretroviral drugs have dropped over the past years, availabili

  1. Human resource management in post-conflict health systems: review of research and knowledge gaps.

    Science.gov (United States)

    Roome, Edward; Raven, Joanna; Martineau, Tim

    2014-01-01

    In post-conflict settings, severe disruption to health systems invariably leaves populations at high risk of disease and in greater need of health provision than more stable resource-poor countries. The health workforce is often a direct victim of conflict. Effective human resource management (HRM) strategies and policies are critical to addressing the systemic effects of conflict on the health workforce such as flight of human capital, mismatches between skills and service needs, breakdown of pre-service training, and lack of human resource data. This paper reviews published literatures across three functional areas of HRM in post-conflict settings: workforce supply, workforce distribution, and workforce performance. We searched published literatures for articles published in English between 2003 and 2013. The search used context-specific keywords (e.g. post-conflict, reconstruction) in combination with topic-related keywords based on an analytical framework containing the three functional areas of HRM (supply, distribution, and performance) and several corresponding HRM topic areas under these. In addition, the framework includes a number of cross-cutting topics such as leadership and governance, finance, and gender. The literature is growing but still limited. Many publications have focused on health workforce supply issues, including pre-service education and training, pay, and recruitment. Less is known about workforce distribution, especially governance and administrative systems for deployment and incentive policies to redress geographical workforce imbalances. Apart from in-service training, workforce performance is particularly under-researched in the areas of performance-based incentives, management and supervision, work organisation and job design, and performance appraisal. Research is largely on HRM in the early post-conflict period and has relied on secondary data. More primary research is needed across the areas of workforce supply, workforce

  2. An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells

    Directory of Open Access Journals (Sweden)

    Grazia Marano

    2012-05-01

    Full Text Available Oligosaccharides aberrantly expressed on tumor cells influence processes such as cell adhesion and modulation of the cell’s microenvironment resulting in an increased malignancy. Schmidt’s imidate strategy offers an effective method to synthesize libraries of various oligosaccharide mimetics. With the aim to perturb interactions of tumor cells with extracellular matrix proteins and host cells, molecules with 3,4-bis(hydroxymethylfuran as core structure were synthesized and screened in biological assays for their abilities to interfere in cell adhesion and other steps of the metastatic cascade, such as tumor-induced angiogenesis.The most active compound, (4-{[(β-D-galactopyranosyloxy]methyl}furan-3-ylmethyl hydrogen sulfate (GSF, inhibited the activation of matrix-metalloproteinase-2 (MMP-2 as well as migration of the human melanoma cells of the lines WM-115 and WM-266-4 in a two-dimensional migration assay. GSF inhibited completely the adhesion of WM-115 cells to the extracellular matrix (ECM proteins, fibrinogen and fibronectin.In an in vitro angiogenesis assay with human endothelial cells, GSF very effectively inhibited endothelial tubule formation and sprouting of blood vessels, as well as the adhesion of endothelial cells to ECM proteins. GSF was not cytotoxic at biologically active concentrations; neither were 3,4-bis{[(β-D-galactopyranosyloxy]methyl}furan (BGF nor methyl β-D-galactopyranoside nor 3,4-bis(hydroxymethylfuran, which were used as controls, eliciting comparable biological activity. In silico modeling experiments, in which binding of GSF to the extracellular domain of the integrin αvβ3 was determined, revealed specific docking of GSF to the same binding site as the natural peptidic ligands of this integrin. The sulfate in the molecule coordinated with one manganese ion in the binding site.These studies show that this chemically easily accessible molecule GSF, synthesized in three steps from 3,4-bis

  3. Human papillomavirus vaccination: assessing knowledge, attitudes, and intentions of college female students in Lebanon, a developing country.

    Science.gov (United States)

    Dany, Mohammed; Chidiac, Alissar; Nassar, Anwar H

    2015-02-18

    Human papillomavirus (HPV) infection is a common cause for genital warts and cervical cancer. Developing countries in the Middle East such as Lebanon are traditionally considered to be conservative societies with low incidence of sexually transmitted infections. However, nowadays, there is an unexpected increase in the incidence of HPV infections among Middle Eastern females. Thus, the objective of this study is to assess the behavioral perceptions of HPV vaccination among female students attending an academic institution in Lebanon. This cross-sectional study invited 512 students to complete a self-administered questionnaire that assessed the knowledge, attitudes, and intentions towards HPV vaccination. Data analysis included the calculation of knowledge scores ranging from 0 to 100, attitude scores ranging from most positive (1) to most negative (5), and intention scores ranging from lowest intention (0) to highest intention (10). With a response rate of n=215 (42%), 36.5% never heard of the vaccine before, and only 16.5% were already HPV vaccinated. The median knowledge score of 52.7% ± 1.71 reflects poor to moderate knowledge. Still, the median attitude score of 2.47 ± 0.05 shows a general positive attitude towards HPV vaccination where most of the participants agreed that female college students in Lebanon have a good chance of contracting HPV (62.1%) and that all gynecologists should recommend the vaccine (76.0%). Students in graduate programs, health related majors, and those who are vaccinated had significantly higher knowledge scores compared with students in undergraduate programs, non-health related majors, and HPV non-vaccinated students, respectively. Finally, the survey helped in increasing the intention to obtain HPV vaccine as the intention score increased significantly from 5.24 ± 0.27 before the students went through the survey to 6.98 ± 0.22 after the students completed the survey. Our study highlights the importance of offering guidance to

  4. [Recent knowledge on the linkage of strain specific genotypes with clinical manifestations of human citomegalovirus disease].

    Science.gov (United States)

    Pignatelli, Sara

    2011-01-01

    Human citomegalovirus (CMV) is a beta-herpesvirus able to establish lifelong persistent infections which usually remain asymptomatic. However, severe diseases may develop in immunocompromised subjects (e.g., AIDS patients and transplant recipients) and if acquired in utero. Circulating CMV clinical strains display genetic polymorphisms in multiple genes, which may be implicated in CMV-induced immunopathogenesis, as well as strain-specific tissue-tropism, viral spread in the host cells and virulence, finally determining the wide spectrum of clinical manifestations of CMV disease. Current literature report a number of studies regarding the main CMV polymorphic genes (UL55-gB, UL144, UL73-gN, UL74-gO), their diagnostic and therapeutic impact, their potential clinical relevance as prognostic markers. This paper aims to critically analyse the results of these studies and evaluate the linkage of strain-specific genotypes with clinical manifestations of CMV disease and their perspective implications.

  5. Filling knowledge gaps in radiation protection methodologies for non-human biota. Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, J.; Gjelsvik, R. (Norwegian Radiation Protection Authority (Norway)); Holm, E. (Univ. of Lund (Sweden)); Roos, P. (Technical Univ. of Denmark, Risoe National Lab. for Sustainable Energy, Roskilde (Denmark)); Saxen, R.; Outola, I. (Radiation and Nuclear Safety Authority (Finland))

    2009-03-15

    The activities of the GAPRAD project are summarised in this report. The background and rationale to GAPRAD are presented and explained. Most notably this relates to a lack of information on naturally occuring radionuclides in terrestrial and aquatic systems that have direct applicability for use in environmental impact assessments. Results from field activities are presented from the Dovrefjell area in Norway (terrestrial study) and selected lake and brackish water systems in Finland. The data mainly concern activity concentrations of Po-210 in environmental media and selected biota allowing concentration ratios to be derived where appropriate. Furthermore, details in relation to Po-210 uptake and biokinetics in humans based on experimental work conducted within the project are presented. (au)

  6. Electronic tracking of human resource skills and knowledge, just in time training, manageable due diligence

    Energy Technology Data Exchange (ETDEWEB)

    Kolodziej, M.A. [Quick Test International Inc., (Canada). Canadian Technology Human Resource Board; Baker, O. [KeySpan Energy Canada, Calgary, AB (Canada)

    2001-06-01

    KeySpan Energy Canada is in the process of obtaining recognition of various occupational profiles including pipeline operators, inspectors, and field and plant operators from various certifying organizations. The process of allowing individuals to obtain certification is recognized by Canadian Technology Human Resources Board as a step towards national standards for technologists and technicians. Proven competency is a must for workers in todays oil industry in response to increasingly stringent government safety regulations, environmental concerns and high public scrutiny. Quick Test international Inc. has developed a management tool in collaboration with end users at KeySpan Energy Canada. It is an electronic, Internet based competency tool for tracking personal competencies and maintaining continued competency. Response to the tool has been favourable. 2 refs., 4 figs.

  7. The i5K Initiative: advancing arthropod genomics for knowledge, human health, agriculture, and the environment.

    Science.gov (United States)

    2013-01-01

    Insects and their arthropod relatives including mites, spiders, and crustaceans play major roles in the world's terrestrial, aquatic, and marine ecosystems. Arthropods compete with humans for food and transmit devastating diseases. They also comprise the most diverse and successful branch of metazoan evolution, with millions of extant species. Here, we describe an international effort to guide arthropod genomic efforts, from species prioritization to methodology and informatics. The 5000 arthropod genomes initiative (i5K) community met formally in 2012 to discuss a roadmap for sequencing and analyzing 5000 high-priority arthropods and is continuing this effort via pilot projects, the development of standard operating procedures, and training of students and career scientists. With university, governmental, and industry support, the i5K Consortium aspires to deliver sequences and analytical tools for each of the arthropod branches and each of the species having beneficial and negative effects on humankind.

  8. Motion-capture-based walking simulation of digital human adapted to laser-scanned 3D as-is environments for accessibility evaluation

    Directory of Open Access Journals (Sweden)

    Tsubasa Maruyama

    2016-07-01

    Full Text Available Owing to our rapidly aging society, accessibility evaluation to enhance the ease and safety of access to indoor and outdoor environments for the elderly and disabled is increasing in importance. Accessibility must be assessed not only from the general standard aspect but also in terms of physical and cognitive friendliness for users of different ages, genders, and abilities. Meanwhile, human behavior simulation has been progressing in the areas of crowd behavior analysis and emergency evacuation planning. However, in human behavior simulation, environment models represent only “as-planned” situations. In addition, a pedestrian model cannot generate the detailed articulated movements of various people of different ages and genders in the simulation. Therefore, the final goal of this research was to develop a virtual accessibility evaluation by combining realistic human behavior simulation using a digital human model (DHM with “as-is” environment models. To achieve this goal, we developed an algorithm for generating human-like DHM walking motions, adapting its strides, turning angles, and footprints to laser-scanned 3D as-is environments including slopes and stairs. The DHM motion was generated based only on a motion-capture (MoCap data for flat walking. Our implementation constructed as-is 3D environment models from laser-scanned point clouds of real environments and enabled a DHM to walk autonomously in various environment models. The difference in joint angles between the DHM and MoCap data was evaluated. Demonstrations of our environment modeling and walking simulation in indoor and outdoor environments including corridors, slopes, and stairs are illustrated in this study.

  9. Human Library——The Innovation of the Mining and Sharing of Library Tacit Knowledge%Human Library——图书馆隐性知识挖掘和共享的创新

    Institute of Scientific and Technical Information of China (English)

    宋鸾姣

    2012-01-01

    This paper briefly introduces the origination and development status of Human Library.By analyzing the existing problems of the excavation and sharing of library tacit knowledge,it discusses that Human Library is the realization approach for the innovation of the excavation and sharing of library tacit knowledge from four perspectives,and suggests some trategies to carry out the excavation and sharing of library tacit knowledge by Human Library.%简单介绍Human Library的起源和发展现状。通过分析图书馆隐性知识挖掘和共享的现存问题,从四个方面论述Human Library是实现图书馆隐性知识挖掘和共享创新的途径,提出通过Human Library开展图书馆隐性知识挖掘和共享的策略。

  10. Knowledge, attitudes, and acceptability of a human papilloma virus vaccine among students, parents and teachers in Thailand.

    Science.gov (United States)

    Songthap, Archin; Pitisuttithum, Punnee; Kaewkungwal, Jaranit; Fungladda, Wijitr; Bussaratid, Valai

    2012-03-01

    The purpose of this study was to assess the knowledge and attitudes about human papilloma virus (HPV) and cervical cancer, and the acceptability of HPV vaccine among students, parents and teachers in secondary schools in Bangkok, Thailand. We conducted a school-based cross-sectional study at four public secondary schools in Bangkok. A total of 644 students aged 12-15 years, 664 parents and 304 teachers were recruited into the study. Data were collected by self-administered questionnaires. The percentages of students, parents and teachers who were willing to be vaccinated were 26, 49 and 43%, respectively. Forty-one percent of parents wanted their children to be vaccinated. Students, parents and teachers had a moderate knowledge of HPV, cervical cancer and the HPV vaccine with mean scores of 6.91 (SD = 1.75), 6.82 (SD = 1.88), and 6.70 (SD = 1.89), respectively. The attitudes of students, parents, and teachers were fair with scores of 3.46 (SD = 0.41), 3.52 (SD = 0.43), and 3.46 (SD = 0.47) out of 5, respectively. Twenty-nine percent of students and 36% of parents were willing to pay USD 14.3-28.5 per dose for the quadrivalent vaccine; 33% of teachers were willing to pay Thailand. The findings suggest the willingness to pay was relatively low and related to the price, while knowledge and attitudes regarding the importance of the HPV vaccine were fair particularly among parents and teachers. Greater effort may be needed to educate people regarding the cost and benefits of HPV vaccination before it would be more acceptable to parents, teachers and students in Thailand.

  11. Knowledge, attitude and performance of wood painter about harmful effects of solvents and dyes on human health

    Directory of Open Access Journals (Sweden)

    Mohammad Miri

    2014-11-01

    Full Text Available Background: Solvents, which are widely used in industry, are able to dissolve another substance for creating a solution. Solvents have various effects on human health based on their type and chemical composition. Methods: This was a cross-sectional study to investigate the harmful effects of solvents on wood painters in Yazd city. To achieve information, a census questionnaire was prepared and distributed among wood painters. The studied parameters include the mean score of knowledge, attitude, and practice of wood painters about harmful effects of dyes and solvents on body according to age, work experience, education, hours worked per day, and smoking. The data of survey were analyzed by Chi-square test and T-test in SPSS. Results: The average age and work experience of wood painters were 29 and 7.5 years, and the age of 25 years and work experience of 5 years had the highest frequency among them. Analysis of data indicated that 71.8% of people had middle school and lower education level, 68.3% was married, 31.7% was single, and 37.5% was smoking. Average working hours were 8 hours in day. Conclusion: Results show that attitudes had significant correlation with education level and different age groups. None of the studied parameters were not significant correlation with performance. Also, there was significant correlation between knowledge with experience.

  12. A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2

    Directory of Open Access Journals (Sweden)

    Shin Sook-Il

    2011-01-01

    Full Text Available Abstract Background Metabolic reconstructions (MRs are common denominators in systems biology and represent biochemical, genetic, and genomic (BiGG knowledge-bases for target organisms by capturing currently available information in a consistent, structured manner. Salmonella enterica subspecies I serovar Typhimurium is a human pathogen, causes various diseases and its increasing antibiotic resistance poses a public health problem. Results Here, we describe a community-driven effort, in which more than 20 experts in S. Typhimurium biology and systems biology collaborated to reconcile and expand the S. Typhimurium BiGG knowledge-base. The consensus MR was obtained starting from two independently developed MRs for S. Typhimurium. Key results of this reconstruction jamboree include i development and implementation of a community-based workflow for MR annotation and reconciliation; ii incorporation of thermodynamic information; and iii use of the consensus MR to identify potential multi-target drug therapy approaches. Conclusion Taken together, with the growing number of parallel MRs a structured, community-driven approach will be necessary to maximize quality while increasing adoption of MRs in experimental design and interpretation.

  13. Knowledge of human papillomavirus infection and its prevention among adolescents and parents in the greater Milan area, Northern Italy

    Directory of Open Access Journals (Sweden)

    Consolo Silvia

    2010-06-01

    Full Text Available Abstract Background In order to be widely accepted by users, the implementation of a new health intervention requires them to be adequately informed about its clinical importance, benefits and risks. The aim of this study was to provide data on the knowledge of Italian adolescents and parents concerning human papillomavirus (HPV infection and its prevention in order to allow the development of adequate training programmes. Methods Between 2 May and 15 June 2008, we made a cross-sectional survey of 863 high school students and 2,331 parents of middle and high school students using two anonymously completed questionnaires covering the knowledge of HPV infection and related diseases, and attitudes to vaccinations. The approached schools were a convenience sample of the schools of the greater Milan area, Northern Italy. Results More mothers than fathers were aware that HPV infection could concern their children (58% vs 53%; p = 0.004 and were favourable towards vaccinating their children against HPV (68% vs 65%; p = 0.03; among the students, more females than males were aware that HPV infection could concern themselves (45% vs 26%; p vs 40%; p Conclusions Both students and parents seem to underestimate the likelihood of HPV infection, and this is associated with a lower propensity for vaccination. This is an important indication for future training programmes concerning HPV prevention designed to increase the acceptance of HPV vaccine in families.

  14. [Knowledge and preventive behaviors related to cervical cancer and human papiloma virus in a group of Chilean adolescents].

    Science.gov (United States)

    Urrutia, M Teresa; Concha, Ximena; Riquelme, Giselle; Padilla, Oslando

    2012-12-01

    The human papilloma virus (HPV) is a common sexually transmitted infection in young people and recognized as the most important risk factor for cervical cancer (CC). To describe the degree of knowledge that a group of Chilean teenagers have of HPV infection, CC, and its relationship with preventive behavior. This is an analytical study, with a random sample of 226 adolescents from three public schools of the Metropolitan Region in Santiago. A fifth of the interviewed students did not know there was a HPV vaccine. Multiple sexual partners was indicated as a risk factor of CC by 70.8% and of HPV infection by 78.3% of them; while 60.3% identified inheritance as a risk factor. HPV transmission through unprotected sexual relations was identified by 68.2% of the sample. Of sexually active adolescents, condom use during sexual relations was reported by 31.1%. The adolescents who use condoms significantly have more knowledge regarding the number of sexual partners and age of first sexual intercourse as a risk factor for CC. adolescents know about HPV transmission, however, the preventing conducts are not related to this information.

  15. Tuberculosis in the era of infection with the human immunodeficiency virus: assessment and comparison of community knowledge of both infections in rural Uganda

    Directory of Open Access Journals (Sweden)

    Wynne Ashley

    2012-12-01

    Full Text Available Abstract Background In Uganda, despite a significant public health burden of tuberculosis (TB in the context of high human immunodeficiency virus (HIV prevalence, little is known about community knowledge of TB. The purpose of this study was to assess and compare knowledge about TB and HIV in the general population of western Uganda and to examine common knowledge gaps and misconceptions. Methods We implemented a multi-stage survey design to randomly survey 360 participants from one district in western Uganda. Weighted summary knowledge scores for TB and HIV were calculated and multiple linear regression (with knowledge score as the dependant variable was used to determine significant predictors. Six focus group discussions were conducted to supplement survey findings. Results Mean (SD HIV knowledge score was 58 (12 and TB knowledge score was 33 (15, both scores out of 100. The TB knowledge score was statistically significantly (p  Conclusion TB knowledge is low and many misconceptions about TB exist: these should be targeted through health education programs. Both TB and HIV-infection knowledge gaps could be better addressed through an integrated health education program on both infections, whereby TB program managers include HIV information and vice versa.

  16. Reviewing the environmental and human health knowledge base of carbon nanotubes.

    Science.gov (United States)

    Helland, Aasgeir; Wick, Peter; Koehler, Andreas; Schmid, Kaspar; Som, Claudia

    2007-08-01

    Carbon nanotubes (CNTs) are considered one of the most promising materials in nanotechnology, with attractive properties for many technologic applications. The different synthesis, purification, and postprocessing methods produce CNTs with different physical characteristics, which can be applied in different fields ranging from composite materials, medical applications, and electronics to energy storage. The widespread projected use of CNTs makes it important to understand their potential harmful effects. In this environmental health review we observed a remarkable range of results of some of the toxicology studies. The comparability should be improved by further standardization and introduction of reference materials. However, at present the findings of this review suggest several key points: a) there are different types of CNTs, and therefore they cannot be considered a uniform group of substances; and b) in environmental compartments, CNTs can be bioavailable to organisms. The properties of CNTs suggest a possible accumulation along the food chain and high persistence. In organisms the absorption, distribution, metabolism, excretion, and toxicity of CNTs depend on the inherent physical and chemical characteristics such as CNT functionalization, coating, length, and agglomeration state that are influenced by the external environmental conditions during CNT production, use, and disposal stages. Characterized exposure scenarios could therefore be useful when conducting toxicologic studies. However, CNTs produce a toxic response upon reaching the lungs in sufficient quantity; this reaction is produced in a time-and dose-dependent manner. The identification of possible risks to human health and environment is a prerequisite for a successful introduction of CNTs in future applications.

  17. Solid knowledge

    DEFF Research Database (Denmark)

    Brix, Anders

    2008-01-01

    The great icons of industrial and architectural design are cornerstones of our material culture. They are referred to again and again in education, research and cultural debate, and as such they have become nodal points of human discourse. The knowledge embedded in such artefacts has often been...... referred to as ‘silent knowledge’....

  18. Knowledge of Human Papillomavirus Infection, Cervical Cancer and Willingness to pay for Cervical Cancer Vaccination among Ethnically Diverse Medical Students in Malaysia.

    Science.gov (United States)

    Maharajan, Mari Kannan; Rajiah, Kingston; Num, Kelly Sze Fang; Yong, Ng Jin

    2015-01-01

    The primary objective of this study was to assess the knowledge of medical students and determine variation between different cultural groups. A secondary aim was to find out the willingness to pay for cervical cancer vaccination and the relationships between knowledge and attitudes towards Human Papillomavirus vaccination. A cross-sectional survey was conducted in a private medical university between June 2014 and November 2014 using a convenient sampling method. A total of 305 respondents were recruited and interviewed with standard questionnaires for assessment of knowledge, attitudes and practice towards human papilloma virus and their willingness to pay for HPV vaccination. Knowledge regarding human papilloma virus, human papilloma virus vaccination, cervical cancer screening and cervical cancer risk factors was good. Across the sample, a majority (90%) of the pupils demonstrated a high degree of knowledge about cervical cancer and its vaccination. There were no significant differences between ethnicity and the participants' overall knowledge of HPV infection, Pap smear and cervical cancer vaccination. Some 88% of participants answered that HPV vaccine can prevent cervical cancer, while 81.5% of medical students said they would recommend HPV vaccination to the public although fewer expressed an intention to receive vaccination for themselves.

  19. Why the Current Insistence on Open Access to Scientific Data? Big Data, Knowledge Production, and the Political Economy of Contemporary Biology

    Science.gov (United States)

    Leonelli, Sabina

    2013-01-01

    The collection and dissemination of data on human and nonhuman organisms has become a central feature of 21st-century biology and has been endorsed by funding agencies in the United States and Europe as crucial to translating biological research into therapeutic and agricultural innovation. Large molecular data sets, often referred to as "big…

  20. How does your own knowledge influence the perception of another person's action in the human brain?

    Science.gov (United States)

    Ramsey, Richard; Hamilton, Antonia F de C

    2012-02-01

    When you see someone reach into a cookie jar, their goal remains obvious even if you know that the last cookie has already been eaten. Thus, it is possible to infer the goal of an action even if you know that the goal cannot be achieved. Previous research has identified distinct brain networks for processing information about object locations, actions and mental-state inferences. However, the relationship between brain networks for action understanding in social contexts remains unclear. Using functional magnetic resonance imaging, this study assesses the role of these networks in understanding another person searching for hidden objects. Participants watched movie clips depicting a toy animal hiding and an actor, who was ignorant of the hiding place, searching in the filled or empty location. When the toy animal hid in the same location repeatedly, the blood oxygen level-dependent (BOLD) response was suppressed in occipital, posterior temporal and posterior parietal brain regions, consistent with processing object properties and spatial attention. When the actor searched in the same location repeatedly, the BOLD signal was suppressed in the inferior frontal gyrus, consistent with the observation of hand actions. In contrast, searches towards the filled location compared to the empty location were associated with a greater response in the medial prefrontal cortex and right temporal pole, which are both associated with mental state inference. These findings show that when observing another person search for a hidden object, brain networks for processing information about object properties, actions and mental state inferences work together in a complementary fashion. This supports the hypothesis that brain regions within and beyond the putative human mirror neuron system are involved in action comprehension within social contexts.

  1. Clinical evidence continuous medical education: a randomised educational trial of an open access e-learning program for transferring evidence-based information - ICEKUBE (Italian Clinical Evidence Knowledge Utilization Behaviour Evaluation) - study protocol.

    Science.gov (United States)

    Moja, Lorenzo; Moschetti, Ivan; Cinquini, Michela; Sala, Valeria; Compagnoni, Anna; Duca, Piergiorgio; Deligant, Christian; Manfrini, Roberto; Clivio, Luca; Satolli, Roberto; Addis, Antonio; Grimshaw, Jeremy M; Dri, Pietro; Liberati, Alessandro

    2008-07-17

    In an effort to ensure that all physicians have access to valid and reliable evidence on drug effectiveness, the Italian Drug Agency sponsored a free-access e-learning system, based on Clinical Evidence, called ECCE. Doctors have access to an electronic version and related clinical vignettes. Correct answers to the interactive vignettes provide Continuing Medical Education credits. The aims of this trial are to establish whether the e-learning program (ECCE) increases physicians' basic knowledge about common clinical scenarios, and whether ECCE is superior to the passive diffusion of information through the printed version of Clinical Evidence. All Italian doctors naïve to ECCE will be randomised to three groups. Group one will have access to ECCE for Clinical Evidence chapters and vignettes lot A and will provide control data for Clinical Evidence chapters and vignettes lot B; group two vice versa; group three will receive the concise printed version of Clinical Evidence. There are in fact two designs: a before and after pragmatic trial utilising a two by two incomplete block design (group one versus group two) and a classical design (group one and two versus group three). The primary outcome will be the retention of Clinical Evidence contents assessed from the scores for clinical vignettes selected from ECCE at least six months after the intervention. To avoid test-retest effects, we will randomly select vignettes out of lot A and lot B, avoiding repetitions. In order to preserve the comparability of lots, we will select vignettes with similar, optimal psychometric characteristics.

  2. Clinical evidence continuous medical education: a randomised educational trial of an open access e-learning program for transferring evidence-based information – ICEKUBE (Italian Clinical Evidence Knowledge Utilization Behaviour Evaluation) – study protocol

    Science.gov (United States)

    Moja, Lorenzo; Moschetti, Ivan; Cinquini, Michela; Sala, Valeria; Compagnoni, Anna; Duca, Piergiorgio; Deligant, Christian; Manfrini, Roberto; Clivio, Luca; Satolli, Roberto; Addis, Antonio; Grimshaw, Jeremy M; Dri, Pietro; Liberati, Alessandro

    2008-01-01

    Background In an effort to ensure that all physicians have access to valid and reliable evidence on drug effectiveness, the Italian Drug Agency sponsored a free-access e-learning system, based on Clinical Evidence, called ECCE. Doctors have access to an electronic version and related clinical vignettes. Correct answers to the interactive vignettes provide Continuing Medical Education credits. The aims of this trial are to establish whether the e-learning program (ECCE) increases physicians' basic knowledge about common clinical scenarios, and whether ECCE is superior to the passive diffusion of information through the printed version of Clinical Evidence. Design All Italian doctors naïve to ECCE will be randomised to three groups. Group one will have access to ECCE for Clinical Evidence chapters and vignettes lot A and will provide control data for Clinical Evidence chapters and vignettes lot B; group two vice versa; group three will receive the concise printed version of Clinical Evidence. There are in fact two designs: a before and after pragmatic trial utilising a two by two incomplete block design (group one versus group two) and a classical design (group one and two versus group three). The primary outcome will be the retention of Clinical Evidence contents assessed from the scores for clinical vignettes selected from ECCE at least six months after the intervention. To avoid test-retest effects, we will randomly select vignettes out of lot A and lot B, avoiding repetitions. In order to preserve the comparability of lots, we will select vignettes with similar, optimal psychometric characteristics. Trial registration ISRCTN27453314 PMID:18637189

  3. Progress in the Development of National Knowledge Infrastructure

    Institute of Scientific and Technical Information of China (English)

    曹存根; 曾庆田; 张春霞; 郑宇飞; 周肖彬; 丰强泽; 高颖; 顾芳; 司晋新; 眭跃飞; 田雯; 王海涛; 王丽丽

    2002-01-01

    This paper presents the recent process in a long-term research project, calledNational Knowledge Infrastructure (or NKI). Initiated in the early 2000, the project aims todevelop a multi-domain shareable knowledge base for knowledge-intensive applications. Todevelop NKI, we have used domain-specific ontologies as a solid basis, and have built morethan 600 ontologies. Using these ontologies and our knowledge acquisition methods, we haveextracted about 1.1 millions of domain assertions. For users to access our NKI knowledge,we have developed a uniform multi-modal human-knowledge interface. We have also imple-mented a knowledge application programming interface for various applications to share theNKI knowledge.

  4. Human Right in Perspective: Inequalities in Access to Water in a Rural Community of the Brazilian Northeast

    OpenAIRE

    Aleixo, Bernardo; Rezende,Sonaly; Pena,João Luiz; Zapata,Gisela; Léo HELLER

    2016-01-01

    Abstract This paper aims to contribute to the debate on the increasing inequalities in access to water and the concentration of the deficit among certain population groups. In particular, it seeks a better understanding of the multiple inequalities of access to water that can exist within a community that lacks a water supply system. Data collection took place in the community of Cristais (Ceará) and included the application of 232 questionnaires to all of the community's heads of household b...

  5. Knowledge and perception of Prevention of Mother to Child services amongst pregnant women accessing antenatal clinic in a Primary Health Care centre in Nigeria

    Directory of Open Access Journals (Sweden)

    Eme T. Owoaje

    2012-10-01

    Full Text Available Background: Few studies have assessed pregnant women’s perceptions regarding prevention of mother to child of HIV and the available services at the primary health care level in Nigeria.Objective: Assessment of knowledge and perception of antenatal clinic (ANC attendees regarding Prevention of Mother to Child Transmission (PMTCT of HIV at primary health care facilities in south-west Nigeria.Method: A cross-sectional survey was conducted amongst 400 antenatal attendees in a Primary Health Care centre in Ibadan, Nigeria.Results: Known methods of PMTCT were: use of anti-retroviral treatment (ART during pregnancy (75.0%, ART at birth (65.8% and not breastfeeding (61.8%. Previous HIV Counselling and Testing (HCT was reported by 71%, significantly higher proportions of thosewho were married, in the third trimester of pregnancy or engaged in professional and/or skilled occupations had been tested. Regarding the HCT services provided, 92.2% understood the HIV-related health education provided, 89.7.2% reported that the timing was appropriate, 92.6% assessed the nurses’ approach as acceptable but 34.0% felt the test was forced upon them. Majority (79.6% were aware of non-breastfeeding options of infant feeding, but only 3.5% were aware of exclusive breastfeeding for a stipulated period as an infant feeding option. Nevertheless, the majority of the women found the non-breast feeding option culturally unacceptable.Conclusion: Women in this survey were knowledgeable about the methods of PMTCT, but had negative perceptions regarding certain aspects of the HCT services and the recommended non-breastfeeding infant feeding option. Health workers should provide client friendly services and infant feeding counselling that is based on current WHO recommendations and culturally acceptable.

  6. Equity in human papilloma virus vaccination uptake? : sexual behaviour, knowledge and demographics in a cross-sectional study in (un)vaccinated girls in the Netherlands

    NARCIS (Netherlands)

    Mollers, Madelief; Lubbers, Karin; Spoelstra, Symen K; Weijmar Schultz, Willibrordus; Daemen, Toos; Westra, Tjalke A; van der Sande, Marianne A B; Nijman, Hans W; de Melker, Hester E; Tami, Adriana

    2014-01-01

    Background: In the Netherlands, human papillomavirus (HPV) vaccination is part of a national program equally accessible for all girls invited for vaccination. To assess possible inequalities in vaccine uptake, we investigated differences between vaccinated and unvaccinated girls with regard to vario

  7. Equity in human papilloma virus vaccination uptake? : sexual behaviour, knowledge and demographics in a cross-sectional study in (un)vaccinated girls in the Netherlands

    NARCIS (Netherlands)

    Mollers, Madelief; Lubbers, Karin; Spoelstra, Symen K; Weijmar Schultz, Willibrordus; Daemen, Toos; Westra, Tjalke A; van der Sande, Marianne A B; Nijman, Hans W; de Melker, Hester E; Tami, Adriana

    2014-01-01

    Background: In the Netherlands, human papillomavirus (HPV) vaccination is part of a national program equally accessible for all girls invited for vaccination. To assess possible inequalities in vaccine uptake, we investigated differences between vaccinated and unvaccinated girls with regard to vario

  8. Scientific controversies on biological knowledge construction: investigating a continued formation course for teachers with respect for human biological evolution

    Directory of Open Access Journals (Sweden)

    Marcelo Erdmann Bulla

    2016-08-01

    Full Text Available The research here presented has as central theme the human biological evolution, its scientific controversies and the continued formation of science and biology teachers. We evaluate the development of a teaching sequence on the topic, emphasizing the scientific controversy regarding the supposed fossil hominid Ardipithecus ramidus (“Ardi” in a continued formation course for teachers of science and biology of basic public network Cascavel-PR and region. The empirical work involved collecting data from the responses provided by teachers to an initial questionnaire and a final. The analysis and data discussion has highlighted the importance of scientific controversy for the development of scientific knowledge and the urgency to insert the contents of human evolution in subjects on the initial formation of courses in licentiate of Biological Sciences. It is necessary also to offer continued formation courses to include such content for teachers already inserted in schools. We conclude that teaching biology and science using scientific controversies may be in satisfactory teaching tool to introduce the history and nature of science, since scientific activity is permeated by conflicts.

  9. The Genexpress IMAGE knowledge base of the human brain transcriptome: a prototype integrated resource for functional and computational genomics.

    Science.gov (United States)

    Piétu, G; Mariage-Samson, R; Fayein, N A; Matingou, C; Eveno, E; Houlgatte, R; Decraene, C; Vandenbrouck, Y; Tahi, F; Devignes, M D; Wirkner, U; Ansorge, W; Cox, D; Nagase, T; Nomura, N; Auffray, C

    1999-02-01

    Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative hybridization of the array with complex probes derived by reverse transcription of mRNA from brain and five other human tissues. Twenty-one percent of the clones corresponded to transcripts that could be classified in general categories of low, moderate, or high abundance. These expression profiles were integrated with cDNA clone and sequence clustering and gene mapping information from an upgraded version of the Genexpress Index. For seven gene transcripts found to be transcribed preferentially or specifically in brain, the expression profiles were confirmed by Northern blot analyses of mRNA from eight adult and four fetal tissues, and 15 distinct regions of brain. In four instances, further documentation of the sites of expression was obtained by in situ hybridization of rat-brain tissue sections. A systematic effort was undertaken to further integrate available cytogenetic, genetic, physical, and genic map informations through radiation-hybrid mapping to provide a unique validated map location for each of these genes in relation to the disease map. The resulting Genexpress IMAGE Knowledge Base is illustrated by five examples presented in the printed article with additional data available on a dedicated Web site at the address http://idefix.upr420.vjf.cnrs.fr/EXPR++ +/ welcome.html.

  10. Demographic, knowledge, attitudinal, and accessibility factors associated with uptake of cervical cancer screening among women in a rural district of Tanzania: Three public policy implications

    Directory of Open Access Journals (Sweden)

    Lyimo Frida S

    2012-01-01

    Full Text Available Abstract Background Cervical cancer is an important public health problem worldwide, which comprises approximately 12% of all cancers in women. In Tanzania, the estimated incidence rate is 30 to 40 per 100,000 women, indicating a high disease burden. Cervical cancer screening is acknowledged as currently the most effective approach for cervical cancer control, and it is associated with reduced incidence and mortality from the disease. The aim of the study was to identify the most important factors related to the uptake of cervical cancer screening among women in a rural district of Tanzania. Methods A cross sectional study was conducted with a sample of 354 women aged 18 to 69 years residing in Moshi Rural District. A multistage sampling technique was used to randomly select eligible women. A one-hour interview was conducted with each woman in her home. The 17 questions were modified from similar questions used in previous research. Results Less than one quarter (22.6% of the participants had obtained cervical cancer screening. The following characteristics, when examined separately in relation to the uptake of cervical cancer screening service, were significant: husband approval of cervical cancer screening, women's level of education, women's knowledge of cervical cancer and its prevention, women's concerns about embarrassment and pain of screening, women's preference for the sex of health provider, and women's awareness of and distance to cervical cancer screening services. When examined simultaneously in a logistic regression, we found that only knowledge of cervical cancer and its prevention (OR = 8.90, 95%CI = 2.14-16.03 and distance to the facility which provides cervical cancer screening (OR = 3.98, 95%CI = 0.18-5.10 were significantly associated with screening uptake. Conclusions Based on the study findings, three recommendations are made. First, information about cervical cancer must be presented to women. Second, public education of

  11. Bilingual lexical access during L1 sentence reading: The effects of L2 knowledge, semantic constraint, and L1-L2 intermixing.

    Science.gov (United States)

    Titone, Debra; Libben, Maya; Mercier, Julie; Whitford, Veronica; Pivneva, Irina

    2011-11-01

    Libben and Titone (2009) recently observed that cognate facilitation and interlingual homograph interference were attenuated by increased semantic constraint during bilingual second language (L2) reading, using eye movement measures. We now investigate whether cross-language activation also occurs during first language (L1) reading as a function of age of L2 acquisition and task demands (i.e., inclusion of L2 sentences). In Experiment 1, participants read high and low constraint English (L1) sentences containing interlingual homographs, cognates, or control words. In Experiment 2, we included French (L2) filler sentences to increase salience of the L2 during L1 reading. The results suggest that bilinguals reading in their L1 show nonselective activation to the extent that they acquired their L2 early in life. Similar to our previous work on L2 reading, high contextual constraint attenuated cross-language activation for cognates. The inclusion of French filler items promoted greater cross-language activation, especially for late stage reading measures. Thus, L1 bilingual reading is modulated by L2 knowledge, semantic constraint, and task demands.

  12. A qualitative study investigating knowledge and attitudes regarding human papillomavirus (HPV) and the HPV vaccine among parents of immunosuppressed children.

    Science.gov (United States)

    Seale, Holly; Trung, Linda; Mackie, Fiona E; Kennedy, Sean E; Boros, Christina; Marshall, Helen; Tidswell, Jane; Shaw, Peter J; Montgomery, Kay; MacIntyre, C Raina

    2012-11-19

    Barriers influencing the willingness of parents to vaccinate immunocompetent children include a lack of knowledge about human papillomavirus (HPV) and low perception of risk regarding their child's acquisition of HPV infection. However, it cannot be assumed that the facilitators and barriers of HPV vaccination are the same for parents/guardians of children who are immunocompromised, or who have chronic medical conditions. This study aimed to document the knowledge and attitudes of parents/guardians of immunosuppressed children and adolescents towards HPV infection and the vaccine. A study using qualitative methods which incorporated 27 semi-structured interviews was undertaken with parents/guardians of immunosuppressed children vaccinated against HPV at three hospitals in two states of Australia. Thematic analysis revealed that while participants acknowledged that they had heard of HPV, they did not have a strong sense of what it actually was. The level of concern held about their child acquiring an HPV infection (prior to vaccination) ranged from 'not at all' to 'extremely'. Some believed that their child was at increased risk of developing a severe HPV-related illness because of their underlying condition. The participants supported their child receiving the HPV vaccine, as they did not want to take a risk with a disease that may cause their child to return to hospital for treatment. The majority had little apprehension about the use of the HPV vaccine but expressed some concern that potential adverse effects would be more severe for immunosuppressed children. However, they stressed their belief in the safety of the vaccine and their trust in the child's health team. Our study results show that parents of children with impaired immunity would benefit from further information about the safety of the vaccine and about the important role of the vaccine for boys as well as girls.

  13. Open Access Publishing

    Directory of Open Access Journals (Sweden)

    Amelia Hadfield

    2013-07-01

    Full Text Available The rise of open source online journals, free online courses, and other changes in the research and education environment, coined the "academic spring" by some commentators, represents an increasing trend in opening up the rules of access for research. Universities, libraries, publishers and even govern­ments are paying attention to this new movement often referred to with the acronym A2K (access to knowledge.

  14. Knowledge Repository for Fmea Related Knowledge

    Science.gov (United States)

    Cândea, Gabriela Simona; Kifor, Claudiu Vasile; Cândea, Ciprian

    2014-11-01

    This paper presents innovative usage of knowledge system into Failure Mode and Effects Analysis (FMEA) process using the ontology to represent the knowledge. Knowledge system is built to serve multi-projects work that nowadays are in place in any manufacturing or services provider, and knowledge must be retained and reused at the company level and not only at project level. The system is following the FMEA methodology and the validation of the concept is compliant with the automotive industry standards published by Automotive Industry Action Group, and not only. Collaboration is assured trough web-based GUI that supports multiple users access at any time

  15. Investigating the Knowledge Management Culture

    Science.gov (United States)

    Stylianou, Vasso; Savva, Andreas

    2016-01-01

    Knowledge Management (KM) efforts aim at leveraging an organization into a knowledge organization thereby presenting knowledge employees with a very powerful tool; organized valuable knowledge accessible when and where needed in flexible, technologically-enhanced modes. The attainment of this aim, i.e., the transformation into a knowledge…

  16. A study of knowledge beliefs and attitudes regarding aids and human sexuality among medical college, engineering college and university Undergraduates of gorakhpur.

    Directory of Open Access Journals (Sweden)

    Puneet Misra

    1997-08-01

    Full Text Available Research Problem: i What is the level of knowledge and altitude of undergraduates about AIDS and human sexuality? ii What arc the preferred modes of obtaining such knowledge?.Objectives: To assess the knowledge, beliefs and attitudes of undergraduate students regarding AIDS and human sexuality.Study Design: Self administered questionnaire.Setting and Participants: 1289 undergraduates from B.R.D. Medical College., M. M. M. Engineering College and University of Gorakhpur.                                                                  .Study Variables: Knowledge, beliefs and attitudes regarding AIDS and sexuality.Outcome Variables: Proportion of students having correct knowledge and positive attitudes.Statistical Analysis: By proportions.Result: l.evcl of knowledge about AIDS was generally high. Most of the students obtained knowledge about it through mass media. Few students had misconceptions about transmission of 1IIV infection. Knowledge about sex was obtained mainly from friends (36% and books (31.31%. Most of the students preferred doctors (44.15% and friends (43.66% for asking something about sex. and not their parents (4.37% or teachers (4.61%. 59.13% of boys and 34.49% of girls thought that students of their age had sex.Conclusion and Recommendations: The most peculiar fact in (his study is that students have no reliable means of obtaining correct information about subjects related to sex. Medical profession contributed very little in providing such knowledge. Most of them relied on their friends for such information. So. emphasis is to be given on recommending proper education material for the youth.

  17. A Political Decision Disguised as Legal Argument? Opinion 2/13 and European Union Accession to the European Convention on Human Rights

    DEFF Research Database (Denmark)

    Butler, Graham

    2015-01-01

    of Copenhagen, Denmark. In this interview, carried out in June 2015 for the Utrecht Journal of International and European Law, David Thór Björgvinsson outlined his views to Graham Butler on Opinion 2/13 from the Court of Justice of the European Union on the Union’s accession to the European Convention on Human...... Rights, the workings of the European Court of Human Rights, and what the future may have in store for this Court.......David Thór Björgvinsson was a judge of the European Court of Human Rights between 2004 and 2013. During this period, he was involved in many important judgments, including Scoppola v Italy (No. 3), Eweida and others v United Kingdom, and Al-Jedda v the United Kingdom, amongst others, and went...

  18. Knowledge Development in Internship

    DEFF Research Database (Denmark)

    Dau, Susanne

    2015-01-01

    The purpose of the chapter is to shed light on how these challenges and tendencies affect students’´ access to tacit and explicit knowledge and the professions’ knowledge development. To address these challenges, the chapter examines the question: How might periods of internship, offering different...

  19. Knowledge Development in Internship

    DEFF Research Database (Denmark)

    Dau, Susanne

    2015-01-01

    The purpose of the chapter is to shed light on how these challenges and tendencies affect students’´ access to tacit and explicit knowledge and the professions’ knowledge development. To address these challenges, the chapter examines the question: How might periods of internship, offering different...

  20. Human Library开创图书馆个体隐性知识管理新模式%Human Library Creates a New Mode to Libraries on Personal Tacit Knowledge Management

    Institute of Scientific and Technical Information of China (English)

    吴云珊

    2011-01-01

    针对图书馆个体隐性知识管理问题,引入国外“真人图书馆”理念,从深度会谈、真人书筛选、非正式学习、借阅制度等方面阐述真人图书馆在个体隐性知识转移上的优势,同时结合其在隐性知识价值凸显和创新上的优势,探讨真人图书馆在图书馆个体隐性知识管理中的价值,得出真人图书馆开创图书馆个体隐性知识管理新模式的结论,以期达到推广真人图书馆、创新图书馆知识服务模式、提高图书馆知识服务水平的目的。%According to the problem of personal tacit knowledge management in libraries, the idea of human library is introduced. Through deep conversation, human book selection, informal learning, rules of loan, certain advantages of human library on personal tacit knowledge transition are expounded. By combining with the advantages on transition, value highlighting anti innovation of personal tacit knowledge, the value of human library in personal tacit knowledge management is discussed. In the hope of spreading human library, making innovations in the library knowledge service mode and improving the knowledge service level of library, it is concluded that human library creates a new mode to libraries on personal tacit knowledge management.

  1. Knowledge Management at CNAT

    Energy Technology Data Exchange (ETDEWEB)

    Callosada, C. de la

    2016-07-01

    Knowledge management at CNAT (Almaraz & Trillo NPPs) representsa significant part of our safety-oriented management system. The purpose is to generate for the stations useful knowledge, which should be then preserved and made easily accessible for everyone in the organization. The aim is to promote knowledge usage for ensuring safe plant operation and facilitating the required generational change-over. In fact, knowledge management is considered one of the main policies at CNAT, with everyone in the organization being expected to collaborate in it. Similarly, some general behavioral expectations at CNAT are directly or indirectly related to knowledge management (i.e. qualification, teamwork, learning and continuous improvement). (Author)

  2. Knowledge, Beliefs and Attitudes of Somali Men in Olmsted County, Minnesota, U.S., on the Human Papillomavirus Vaccine and Cervical Cancer Screening: January 17, 2015.

    Science.gov (United States)

    Abakporo, Uzoma; Hussein, Abdirahman; Begun, James W; Shippee, Tetyana

    2017-08-16

    This study explores the general knowledge of Human Papillomavirus vaccine (HPV) and cervical cancer screening (CCS) among Somali men in the U.S., who are major decision-makers in Somali households. HPV infects both men and women, and causes genital warts and cervical cancer (CC). High mortality from CC persists among minorities due to low uptake of preventive tools. Eleven questions assessed general knowledge of HPV and CCS among 30 Somali male respondents. The knowledge of HPV and CCS by education level, age, and years lived in the U.S., was assessed using the health belief model. Most respondents had no knowledge of HPV vaccine and CCS, and low perceived susceptibility to HPV infection. There is need for more research on Somali men's attitude to HPV vaccine and CCS uptake among Somali adolescents and women.

  3. Global access to infertility care in developing countries: a case of human rights, equity and social justice.

    Science.gov (United States)

    Ombelet, W

    2011-01-01

    According to WHO data more than 180 million couples in developing countries suffer from primary or secondary infertility. The social stigma of childlessness still leads to isolation and abandonment in many developing countries. Differences between the developed and developing world are emerging because of the different availability in infertility care and different socio-cultural value surrounding procreation and childlessness. Although reproductive health education and prevention of infertility are number one priorities, the need for accessible diagnostic procedures and new reproductive technologies (ART) is very high. The success and sustainability of ART in resource-poor settings will depend to a large extend on our ability to optimise these techniques in terms of availability, affordability and effectiveness. Accessible infertility treatment can only be successfully introduced in developing countries if socio-cultural and economic prerequisites are fulfilled and governments can be persuaded to support their introduction. We have to liaise with the relevant authorities to discuss the strengthening of infertility services, at the core of which lies the integration of infertility, contraceptive and maternal health services within public health care structures. After a fascinating period of more than 30 years of IVF, only a small part of the world population benefits from these new technologies. Time has come to give equitable access to effective and safe infertility care in resource-poor countries as well.

  4. Global access to infertility care in developing countries: a case of human rights, equity and social justice

    Science.gov (United States)

    Ombelet, W.

    2011-01-01

    According to WHO data more than 180 million couples in developing countries suffer from primary or secondary infertility. The social stigma of childlessness still leads to isolation and abandonment in many developing countries. Differences between the developed and developing world are emerging because of the different availability in infertility care and different socio-cultural value surrounding procreation and childlessness. Although reproductive health education and prevention of infertility are number one priorities, the need for accessible diagnostic procedures and new reproductive technologies (ART) is very high. The success and sustainability of ART in resource-poor settings will depend to a large extend on our ability to optimise these techniques in terms of availability, affordability and effectiveness. Accessible infertility treatment can only be successfully introduced in developing countries if socio-cultural and economic prerequisites are fulfilled and governments can be persuaded to support their introduction. We have to liaise with the relevant authorities to discuss the strengthening of infertility services, at the core of which lies the integration of infertility, contraceptive and maternal health services within public health care structures. After a fascinating period of more than 30 years of IVF, only a small part of the world population benefits from these new technologies. Time has come to give equitable access to effective and safe infertility care in resource-poor countries as well. PMID:24753875

  5. Attitudes, Knowledge and Factors Associated with Human Papillomavirus (HPV) Vaccine Uptake in Adolescent Girls and Young Women in Victoria, Australia

    Science.gov (United States)

    Tung, Iris L. Y.; Machalek, Dorothy A.; Garland, Suzanne M.

    2016-01-01

    Background Human papillomavirus (HPV) vaccination targets high-risk HPV16/18 that cause 70% of all cancers of the cervix. In Australia there is a fully-funded, school-based National HPV Vaccination Program which has achieved vaccine initiation rate of 82% among age-eligible females. Improving HPV vaccination rates is important in the prevention of morbidity and mortality associated with HPV-related disease. This study aimed to identify factors and barriers associated with uptake of the HPV vaccine in the Australian Program. Methods Between 2011 and 2014, females aged 18–25 years, living in Victoria, Australia who were offered HPV vaccination between 2007 and 2009 as part of the National HPV Vaccination Program, living in Victoria, Australia were recruited into a a young women’s study examining effectiveness of the Australian National HPV Vaccination Program. Overall, 668 participants completed the recruitment survey, which collected data of participants’ demographics and HPV knowledge. In 2015 these participants were invited to complete an additional supplementary survey on parental demographics and attitudes towards vaccinations. Results In 2015, 417 participants completed the supplementary survey (62% response rate). Overall, 19% of participants were unvaccinated. In multivariate analyses, HPV vaccination was significantly associated with their being born in Australia (pparents being main decision-makers for participants’ HPV vaccination (pparental concern about vaccine safety (43%). Compared with HPV-vaccinated participants, those unvaccinated were significantly more likely to be opposed to all vaccines, including HPV vaccines (p<0.001) and were less likely to consider vaccinating their own children with all vaccines (p = 0.033), including HPV vaccines (p<0.001). Overall, 61% of unvaccinated participants reported that a recommendation from GPs would increase HPV vaccine acceptance. Conclusions Attitudes towards general health, vaccinations in general, as

  6. The human interactome knowledge base (hint-kb): An integrative human protein interaction database enriched with predicted protein–protein interaction scores using a novel hybrid technique

    KAUST Repository

    Theofilatos, Konstantinos A.

    2013-07-12

    Proteins are the functional components of many cellular processes and the identification of their physical protein–protein interactions (PPIs) is an area of mature academic research. Various databases have been developed containing information about experimentally and computationally detected human PPIs as well as their corresponding annotation data. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://biotools.ceid.upatras.gr/hint-kb/), a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, cal-culatesasetoffeaturesofinterest and computesaconfidence score for every candidate protein interaction. This confidence score is essential for filtering the false positive interactions which are present in existing databases, predicting new protein interactions and measuring the frequency of each true protein interaction. For this reason, a novel machine learning hybrid methodology, called (Evolutionary Kalman Mathematical Modelling—EvoKalMaModel), was used to achieve an accurate and interpretable scoring methodology. The experimental results indicated that the proposed scoring scheme outperforms existing computational methods for the prediction of PPIs.

  7. Open access

    NARCIS (Netherlands)

    Valkenburg, P.M.

    2015-01-01

    Open access week Van 19 tot en met 25 oktober 2015 vond wereldwijd de Open Access Week plaats. Tijdens deze week werden er over de hele wereld evenementen georganiseerd waar open access een rol speelt. Ook in Nederland zijn er diverse symposia, workshops en debatten georganiseerd zoals het debat in

  8. The Research on"Human Library"and Library's Knowledge Service Strategies%"Human Library"与图书馆知识服务的策略研究

    Institute of Scientific and Technical Information of China (English)

    舒文刚

    2015-01-01

    "Human Library"作为一种全新的知识服务理念与服务模式,在图书馆知识服务方面具有鲜活、独特的优势.阐述了"Human Library"与图书馆知识服务的概念,提出了"Human Library"与图书馆知识服务的策略,包括加强宣传以提高社会认可、增进共识以促进合作共赢、完善制度以推进规范管理.%"Human Library", being as a new idea and pattern of knowledge service, has fresh and unique advantages in library's knowledge service. This paper expounds the concepts of"human library"and library's knowledge service, and puts forward the strategies for "human library"and library's knowledge service, which include strengthening the propaganda to improve the social acceptance, broadening the mutual understanding to promote the win-win cooperation, and perfecting the system to to promote standard management.

  9. Knowledge management

    OpenAIRE

    Jarošová, Milena

    2008-01-01

    Theoretical part: Basic terms of knowledge management, knowledge worker, knowledge creation and conversion process, prerequisites and benefits of knowledge management. Knowledge management and it's connection to organizational culture and structure, result measurements of knowledge management, learning organization and it's connection to knowledge management. Tacit knowledge management tools -- stories -- types, how to create, practical use, communities, coaching. Value Based Organization. Pr...

  10. Knowledge and awareness of human papillomavirus (HPV), cervical cancer and HPV vaccine among women in two distinct Nepali communities

    National Research Council Canada - National Science Library

    Johnson, Derek Christopher; Bhatta, Madhav Prasad; Gurung, Santosh; Aryal, Shilu; Lhaki, Pema; Shrestha, Sadeep

    2014-01-01

    .... Experienced staff administered a Nepali language survey instrument that included questions on socio-demographics, reproductive health and knowledge on HPV, cervical cancer, and the HPV vaccine...

  11. Open access, readership, citations: a randomized controlled trial of scientific journal publishing.

    Science.gov (United States)

    Davis, Philip M

    2011-07-01

    Does free access to journal articles result in greater diffusion of scientific knowledge? Using a randomized controlled trial of open access publishing, involving 36 participating journals in the sciences, social sciences, and humanities, we report on the effects of free access on article downloads and citations. Articles placed in the open access condition (n=712) received significantly more downloads and reached a broader audience within the first year, yet were cited no more frequently, nor earlier, than subscription-access control articles (n=2533) within 3 yr. These results may be explained by social stratification, a process that concentrates scientific authors at a small number of elite research universities with excellent access to the scientific literature. The real beneficiaries of open access publishing may not be the research community but communities of practice that consume, but rarely contribute to, the corpus of literature.

  12. Access, ethics and piracy

    Directory of Open Access Journals (Sweden)

    Stuart Lawson

    2017-03-01

    Full Text Available Ownership of intellectual property rights for a large proportion of the scholarly record is held by publishers, so a majority of journal articles are behind paywalls and unavailable to most people. As a result some readers are encouraged to use pirate websites such as Sci-Hub to access them, a practice that is alternately regarded as criminal and unethical or as a justified act of civil disobedience. This article considers both the efficacy and ethics of piracy, placing ‘guerrilla open access’ within a longer history of piracy and access to knowledge. By doing so, it is shown that piracy is an inevitable part of the intellectual landscape that can render the current intellectual property regime irrelevant. If we wish to actively construct a true scholarly commons, open access emerges as a contender for moving beyond proprietary forms of commodifying scholarly knowledge towards the creation of an open scholarly communication system that is fit for purpose.

  13. The Prevalence of Different Human Immunodeficiency Virus Transmission Routes and Knowledge about AIDS in Infected People with HIV in Sirjan

    Directory of Open Access Journals (Sweden)

    Mahin Behzadpour

    2012-06-01

    Full Text Available Background & Objective: The immune system of Patients with Acquired Immune Deficiency Syndrome (AIDS is weekend because of Human immunodeficiency virus (HIV infection, and they become vulnerable to several opportunistic and non-opportunistic pathogens and different carcinomas. IV drug abuse, sexual contact, occupational transmission, blood transfusion and maternal-fetal transmission are well known transmission routes for HIV infection. This study was under taken to investigate the prevalence of HIV transmission routs in the HIV infected population of Sirjan, and their knowledge about the disease, in order to plan better preventive strategies. Materials & Methods: A cross sectional study was planned. During a 6-month period in 2010, all of the HIV infected people in Sirjan (old and new cases who had a file at the consultation center for high risk behavior, completed a valid and reliable questionnaire. Results: The definite route of transmission was not clear in any of the patients because they had more than one suspicious route. Injected drug abusers were the most common (88.4% followed by those who got tattoos (79.1%, invasive therapeutic procedures, dentistry, surgery and endoscopy (56.1%, high risk sexual behavior (62.8%, bloodletting (9.3%, injuries in the barbershop (9.3% and blood transfusion (2.3%. Conclusion: All of the HIV infected cases in Sirjan were involved with several high risk behaviors, but the major route of transmission, similar to other parts of the country was injected drug abuse. Educational programs for prevention of AIDS should be followed seriously and special attention should be paid to groups with multiple high risk behaviors.

  14. Metacognitive Model of Tacit Knowledge Transfer in Human Library%真人图书馆隐性知识转移的元认知模式

    Institute of Scientific and Technical Information of China (English)

    王培林

    2016-01-01

    To find a solution for“how to transfer tacit knowledge in human library”,this article combines Flavell’ s metacognitive theory with Dr. Dong’s metacognitive ideas to explore the metacognitive model of tacit knowledge transfer in human library and its operating mechanism based on the analysis of metacognitive dimensions of tacit knowledge. The results show that it need to establish a “3+1” metacognition mechanism for tacit knowledge transfer in human library in order to achieve the transfer successfully.%文章针对真人图书馆中隐性知识如何转移,引入Flavell的元认知理论及董奇的元认知观点,在分析隐性知识元认知维度的基础上,探索真人图书馆隐性知识转移的元认知模式,据此提出推动真人图书馆隐性知识转移的运行机制。研究结果显示,要成功实现真人图书馆隐性知识转移,需要建立“3+1”真人图书馆隐性知识转移元认知机制。

  15. Moving forward on human resources for health: next steps for scaling up toward universal access to HIV/AIDS prevention, treatment, and care.

    Science.gov (United States)

    Gormley, Wilma; McCaffery, James; Quain, Estelle E

    2011-08-01

    In 2008, the Global Health Workforce Alliance commissioned a technical working group to examine the human resources for health implications of scaling up to reach the Millennium Development Goal 6 of universal access to HIV/AIDS prevention, treatment, care, and support by 2010. The analysis and interventions recommended in the working group report, which was launched at the Second Global Forum on Human Resources for Health in Bangkok, Thailand, in January 2011, are based on two research methods: literature reviews covering the period from 2000 to 2008 and a rapid situational analysis produced by teams working in 5 countries (Côte d'Ivoire, Ethiopia, Mozambique, Thailand, and Zambia). The authors' intent in this article is to assist the Alliance in maintaining the momentum of the forum and the enthusiasm generated by the working group's report to make a difference at the country level by moving from recommendation to action.

  16. The human genome project: Information management, access, and regulation. Technical progress report, 1 April--31 August 1993

    Energy Technology Data Exchange (ETDEWEB)

    McInerney, J.D.; Micikas, L.B.

    1993-09-10

    Efforts are described to prepare educational materials including computer based as well as conventional type teaching materials for training interested high school and elementary students in aspects of Human Genome Project.

  17. Research on Economics and Management%The Relationship Between Organizational Trust and Knowledge Sharing-Roles of Organizational Identification and High Commitment Human Resource Practices

    Institute of Scientific and Technical Information of China (English)

    刘宗华; 李燕萍; 郭昱琅; 郑馨怡

    2016-01-01

    From the perspective of self-concept,this study explores the effects of organizational trust on employees'knowledge sharing behavior,and examines the relationship between organizational trust and knowledge sharing based on multiple regression analysis of 288 subordinate-supervisors from 7 companies.The results indicate that organizational trust has significantly positive effect on knowledge sharing and organizational identification;organizational identification has significantly positive effect on knowledge sharing;organizational identification partially plays a mediating role in the relationship between organizational trust and knowledge sharing;high commitment human resource practices(HCHRPs) play a positive moderating role in the relationship between organizational identification and knowledge sharing;and high commitment human resource practices(HCHRPs)also moderate the indirect relationship between organizational trust and knowledge sharing via organizational identification.%本文基于自我概念的视角引入组织信任探讨员工的知识分享行为。以来自7家企业的288份直接主管-下属配对样本,探讨组织信任与知识分享的关系。研究发现,组织信任对知识分享、组织认同有显著正向影响,组织认同对知识分享有显著正向影响,组织认同部分中介组织信任对知识分享的作用;高承诺人力资源实践在组织认同与知识分享的关系中起正向调节作用;高承诺人力资源实践调节组织信任对知识分享影响的间接效应。

  18. The Effects of Learning Organization Culture on the Practices of Human Knowledge-Creation: An Empirical Research Study in Korea

    Science.gov (United States)

    Song, Ji Hoon

    2008-01-01

    This research aims to identify the influence of learning organization culture on the practices of organizational knowledge-creation. Actionable knowledge-creation practices are put forward as a variable in preference to the learning process itself because they may be more closely related to the achievement of individual and/or organizational…

  19. Landscape-scale accessibility of livestock to tigers: implications of spatial grain for modeling predation risk to mitigate human-carnivore conflict.

    Science.gov (United States)

    Miller, Jennifer R B; Jhala, Yadvendradev V; Jena, Jyotirmay; Schmitz, Oswald J

    2015-03-01

    Innovative conservation tools are greatly needed to reduce livelihood losses and wildlife declines resulting from human-carnivore conflict. Spatial risk modeling is an emerging method for assessing the spatial patterns of predator-prey interactions, with applications for mitigating carnivore attacks on livestock. Large carnivores that ambush prey attack and kill over small areas, requiring models at fine spatial grains to predict livestock depredation hot spots. To detect the best resolution for predicting where carnivores access livestock, we examined the spatial attributes associated with livestock killed by tigers in Kanha Tiger Reserve, India, using risk models generated at 20, 100, and 200-m spatial grains. We analyzed land-use, human presence, and vegetation structure variables at 138 kill sites and 439 random sites to identify key landscape attributes where livestock were vulnerable to tigers. Land-use and human presence variables contributed strongly to predation risk models, with most variables showing high relative importance (≥0.85) at all spatial grains. The risk of a tiger killing livestock increased near dense forests and near the boundary of the park core zone where human presence is restricted. Risk was nonlinearly related to human infrastructure and open vegetation, with the greatest risk occurring 1.2 km from roads, 1.1 km from villages, and 8.0 km from scrubland. Kill sites were characterized by denser, patchier, and more complex vegetation with lower visibility than random sites. Risk maps revealed high-risk hot spots inside of the core zone boundary and in several patches in the human-dominated buffer zone. Validation against known kills revealed predictive accuracy for only the 20 m model, the resolution best representing the kill stage of hunting for large carnivores that ambush prey, like the tiger. Results demonstrate that risk models developed at fine spatial grains can offer accurate guidance on landscape attributes livestock should

  20. Knowledge Yearning for Freedom

    Directory of Open Access Journals (Sweden)

    Ljiljana Gavrilović

    2016-02-01

    Full Text Available The paper is concerned with the restriction of access to knowledge/books in the contemporary digitalized global world, in which the access to knowledge has to be paid for, and wherein definitions of modes of payment control who has or doesn’t have the right to knowledge. The second part of the article deals with the struggle for the freedom of words/knowledge, and actions through which the authors/producers of knowledge and art fight the restrictions not only to the freedom of speech, but also creativity and innovation, which should be the aim of all copyright and intellectual right laws, the contemporary application of which has become its own opposite.