WorldWideScience

Sample records for acceptance model tam

  1. APLIKASI TECHNOLOGY ACCEPTANCE MODEL (TAM) PADA KOMPUTERISASI KEGIATAN PERTANAHAN

    OpenAIRE

    Wahyu Prabawati Putri Handayani; Mugi Harsono

    2016-01-01

    Abstrak: Aplikasi Technology Acceptance Model (TAM) Pada Komputerisasi Kegiatan Pertanahan. Tujuan penelitian ini adalah untuk menguji dan menganalisis pengaruh Technology Acceptance Model (TAM) Pada Komputerisasi Kegiatan Pertanahan. Sebuah metodologi survey digunakan untuk mengumpulkan data 100 karyawan. Path analysis menunjukkan bahwa (1) Computer self-efficacy berpengaruh pada persepsi kemudahan penggunaan dan persepsi manfaat teknologi, (2) Persepsi kemudahan penggunaan teknologi berpeng...

  2. Technology Acceptance Model (TAM) untuk Menganalisis Penerimaan terhadap Sistem Informasi di PerpustakaanM INFORMASI PERPUSTAKAAN

    OpenAIRE

    Fatmawati, Endang

    2015-01-01

    Technology acceptance can be defined as a user's willingness to employ technology for the tasks it is designed to support. Technology Acceptance Model (TAM) introduced by Davis in 1986. TAM is considers user perceptions of ease of use and usefulness as the main factors affecting the acceptance level of any technology. TAM is model for explaining and predicting information system use in library. TAM model to determine the attitude of users towards a technology acceptance.

  3. Kajian Online Sistem Informasi BRI (BRINETS: Pendekatan Technology Acceptance Model (TAM

    Directory of Open Access Journals (Sweden)

    Wahyu Meiranto

    2011-04-01

    Full Text Available Study of BRI Online Information System (BRINETS: Technology Acceptance Model (TAM Approach. The purpose of this research is to analyze factors that effecting acceptance and actual use of BRI technology information system (BRINETS using TAM (Technology Acceptance Model. Two variables of TAM used in this research are perceived ease of use and perceived of usefullness. Samples of the research were BRINETS users at BRI Semarang. There were 70 respondents involved. The data was analyzed by using PLS. The results indicate that experience and complexity have significant effect to perceived ease of use. Furthermore, perceived ease of use significantly affected the attitude toward using technology. Finally, behaviour intention significantly influence the actual use of technology

  4. Application of the Technology Acceptance Model (TAM) in electronic ...

    African Journals Online (AJOL)

    Application of the Technology Acceptance Model (TAM) in electronic ticket purchase for ... current study examined the perceived usefulness and ease of use of online technology ... The findings are discussed in the light of these perspectives.

  5. MODEL PERILAKU PENGGUNAAN TIK “NR2007” PENGEMBANGAN DARI TECHNOLOGY ACCEPTANCE MODEL (TAM

    Directory of Open Access Journals (Sweden)

    Neila Ramdhani

    2016-06-01

    Full Text Available This paper discusses and criticizes a Technology Acceptance Model which was developed by Fred D. Davis in 1986. TAM was built to predict the way people accept and adopt the technology. TAM was inspired by theory of reasoned action (TRA formulated by Martin Fishbein & Icek Ajzen in 1975, although the model does not completely adopt the TRA model. TAM does not include Subjective Norm as a factor in predicting the use of technology. As a theory, TAM has been used by many researchers to investigate the adoption of information technology. This model has a significant contribution in predicting the use of information communication technology (ICT in many areas. Since ICT users have various motivational backgrounds, some of them have a positive attitude toward ICT, but they do not use ICT. It seems the TAM model need to be improved by including Subjective Norms and Perceived Behavior Control as suggested by Ajzen in the theory of planned behavior (TPB as antecedents of intention to use ICT. Since the personality background of ICT users may also influence the use of ICT, the author proposes TAM‐NR‐2007 model that include personality traits as a background factor of attitude toward the behavior and subjective norms.

  6. Modeling the acceptance of clinical information systems among hospital medical staff: an extended TAM model.

    Science.gov (United States)

    Melas, Christos D; Zampetakis, Leonidas A; Dimopoulou, Anastasia; Moustakis, Vassilis

    2011-08-01

    Recent empirical research has utilized the Technology Acceptance Model (TAM) to advance the understanding of doctors' and nurses' technology acceptance in the workplace. However, the majority of the reported studies are either qualitative in nature or use small convenience samples of medical staff. Additionally, in very few studies moderators are either used or assessed despite their importance in TAM based research. The present study focuses on the application of TAM in order to explain the intention to use clinical information systems, in a random sample of 604 medical staff (534 physicians) working in 14 hospitals in Greece. We introduce physicians' specialty as a moderator in TAM and test medical staff's information and communication technology (ICT) knowledge and ICT feature demands, as external variables. The results show that TAM predicts a substantial proportion of the intention to use clinical information systems. Findings make a contribution to the literature by replicating, explaining and advancing the TAM, whereas theory is benefited by the addition of external variables and medical specialty as a moderator. Recommendations for further research are discussed. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Utilization of Multimedia Laboratory: An Acceptance Analysis using TAM

    Science.gov (United States)

    Modeong, M.; Palilingan, V. R.

    2018-02-01

    Multimedia is often utilized by teachers to present a learning materials. Learning that delivered by multimedia enables people to understand the information of up to 60% of the learning in general. To applying the creative learning to the classroom, multimedia presentation needs a laboratory as a space that provides multimedia needs. This study aims to reveal the level of student acceptance on the multimedia laboratories, by explaining the direct and indirect effect of internal support and technology infrastructure. Technology Acceptance Model (TAM) is used as the basis of measurement on this research, through the perception of usefulness, ease of use, and the intention, it’s recognized capable of predicting user acceptance about technology. This study used the quantitative method. The data analysis using path analysis that focuses on trimming models, it’s performed to improve the model of path analysis structure by removing exogenous variables that have insignificant path coefficients. The result stated that Internal Support and Technology Infrastructure are well mediated by TAM variables to measure the level of technology acceptance. The implications suggest that TAM can measure the success of multimedia laboratory utilization in Faculty of Engineering UNIMA.

  8. Understanding Student Teachers' Behavioural Intention to Use Technology: Technology Acceptance Model (TAM) Validation and Testing

    Science.gov (United States)

    Wong, Kung-Teck; Osman, Rosma bt; Goh, Pauline Swee Choo; Rahmat, Mohd Khairezan

    2013-01-01

    This study sets out to validate and test the Technology Acceptance Model (TAM) in the context of Malaysian student teachers' integration of their technology in teaching and learning. To establish factorial validity, data collected from 302 respondents were tested against the TAM using confirmatory factor analysis (CFA), and structural equation…

  9. Understanding Student Teachers’ Behavioural Intention to Use Technology: Technology Acceptance Model (TAM Validation and Testing

    Directory of Open Access Journals (Sweden)

    Kung-Teck, Wong

    2013-01-01

    Full Text Available This study sets out to validate and test the Technology Acceptance Model (TAM in the context of Malaysian student teachers’ integration of their technology in teaching and learning. To establish factorial validity, data collected from 302 respondents were tested against the TAM using confirmatory factor analysis (CFA, and structural equation modelling (SEM was used for model comparison and hypotheses testing. The goodness-of-fit test of the analysis shows partial support of the applicability of the TAM in a Malaysian context. Overall, the TAM accounted for 37.3% of the variance in intention to use technology among student teachers and of the five hypotheses formulated, four are supported. Perceived usefulness is a significant influence on attitude towards computer use and behavioural intention. Perceived ease of use significantly influences perceived usefulness, and finally, behavioural intention is found to be influenced by attitude towards computer use. The findings of this research contribute to the literature by validating the TAM in the Malaysian context and provide several prominent implications for the research and practice of technology integration development.

  10. Extended TAM Model: Impacts of Convenience on Acceptance and Use of Moodle

    Science.gov (United States)

    Hsu, Hsiao-hui; Chang, Yu-ying

    2013-01-01

    The increasing online access to courses, programs, and information has shifted the control and responsibility of learning process from instructors to learners. Learners' perceptions of and attitudes toward e-learning constitute a critical factor to the success of such system. The purpose of this study is to take TAM (technology acceptance model)…

  11. Understanding intention to use electronic information resources: A theoretical extension of the technology acceptance model (TAM).

    Science.gov (United States)

    Tao, Donghua

    2008-11-06

    This study extended the Technology Acceptance Model (TAM) by examining the roles of two aspects of e-resource characteristics, namely, information quality and system quality, in predicting public health students' intention to use e-resources for completing research paper assignments. Both focus groups and a questionnaire were used to collect data. Descriptive analysis, data screening, and Structural Equation Modeling (SEM) techniques were used for data analysis. The study found that perceived usefulness played a major role in determining students' intention to use e-resources. Perceived usefulness and perceived ease of use fully mediated the impact that information quality and system quality had on behavior intention. The research model enriches the existing technology acceptance literature by extending TAM. Representing two aspects of e-resource characteristics provides greater explanatory information for diagnosing problems of system design, development, and implementation.

  12. Examining the Antecedents of ICT Adoption in Education Using an Extended Technology Acceptance Model (TAM)

    Science.gov (United States)

    Teeroovengadum, Viraiyan; Heeraman, Nabeel; Jugurnath, Bhavish

    2017-01-01

    This study assesses the determinants of ICT adoption by educators in the teaching and learning process in the context of a developing country, Mauritius. A hierarchical regression analysis is used, to firstly determine the incremental effects of factors from the technology acceptance model (TAM) while controlling for demographic variables such as…

  13. TAM-based external factors related to ERP solutions acceptance in organizations

    Directory of Open Access Journals (Sweden)

    Simona Zabukovsek

    2013-01-01

    Full Text Available To improve the efficiency and effectiveness of ERP solutions use, understanding of critical success factors of ERP solutions assimilation in organizations is crucial. The technology acceptance model (TAM proposed by Davis (1989 has been the most widely used model for researching user acceptance and usage of IT/IS. The purpose of this paper is to extend the original TAM with groups of external factors which impact actual ERP system use. First, we focus on ERP system use in companies’ maturity phase. Second, we expose and examine three groups of external factors which influence ERP usage. The model was empirically tested using data collected from a survey of ERP users in 44 organizations. Survey data have been collected from ERP users who have been exposed to an ERP system which has operated for more than one year. The proposed research model was analyzed using the PLS approach.

  14. The Influence On Factors In Attitudes Toward Acceptance Of The Information System Using Technology Acceptance Model TAM Case Study SPAN System In Indonesia

    Directory of Open Access Journals (Sweden)

    Donny Maha Putra

    2015-08-01

    Full Text Available Theoretically and practically Technology Acceptance Model TAM is a model that is considered most appropriate in explaining how the user receives a system. This study aimed to analyze the factors that influence the attitudes towards the acceptance of Sistem Perbendaharaan Anggaran Negara SPAN using TAM approach. The problems raised in this research aims to determine the attitude of the use of the transition process lagecy system to the new system which for many users create conflict in the process of adaptation. On the basis of this proposed theoretical models to test hypotheses using Structural Equation Model SEM and analysis tool using lisrel. This research was conducted in all offices DG of Treasury of Ministry of Finance with 210 respondents were chosen at random to represent each office. The results of this study prove 4 hypothesis is accepted from 8 hypothesis namely a a negative affect with the results demonstrabilty b computer self-efficacy with the output quality c computer self-efficacy with the perceived ease of use d perceived ease of use with the perceived of usefulness. Overall indicates that the application of the SPAN system in the Ministry of Finance of In Indonesia can be accepted by users.

  15. Penelitian Perilaku Pengguna Internet Pada Desa Pinter Hasil Pembangunan USO dengan Pendekatan Technology Acceptance Model (TAM di Provinsi Jawa Tengah

    Directory of Open Access Journals (Sweden)

    Lasni Julita Siahaan

    2011-03-01

    Full Text Available Fasilitas internet yang dibangun dengan proyek USO adalah suatu teknologi baru yang dapat menimbulkan reaksi pada penggunanya, baik reaksi menerima maupun reaksi menolak. Oleh karena itu, perlu diketahui model penerimaan teknologi tersebut serta factor-faktor yang berpengaruh terhadap penerimaanya. Salah satu model penerimaan pemakai terhadap teknologi yang paling sesuai sampai sekarang adalah technology acceptance model (TAM yang dikemukakan oleh Davis dan Khosrow-Pour (2006: 209. Bagaimana kecocokan model TAM dalam menilai penerimaan pengguna terhadap fasilitas internet tersebut dianalisis dengan structural equation modeling (SEM. Pendekatan dalam penelitian ini adalan kuantitatif dengan melakukan survey kepada masyarakat di sekitar lokasi pembangunan proyek USO di Propinsi Jawa Tengah. Hasil penelitian menunjukkan bahwa model TAM dapat digunakan menilai perilaku masyarakat di sekitar lokasi pembangunan proyek USO dalam menerima dan memanfaatkan fasilitas Internet.

  16. A Qualitative Case Study to Investigate the Technology Acceptance Experience Outlined in the TAM Using the Kubler-Ross Stages of Grieving and Acceptance

    Science.gov (United States)

    Sotelo, Benjamin Eladio

    2015-01-01

    The Technology Acceptance Model (TAM) has been an important model for the understanding of end user acceptance regarding technology and a framework used in thousands of researched scenarios since publication in 1986. Similarly, the Kubler-Ross model of death and dying has also been used as a model for the study of acceptance within the medical…

  17. The Influence of Technology Acceptance Model (TAM on The Users’ Behavior of Sikesya Application in IAIN Surakarta

    Directory of Open Access Journals (Sweden)

    Tri Wahyuni

    2016-04-01

    Full Text Available This study aims to evaluate the student acceptance of SIKESYA  (Sharia Financial System/Sikesya application as the users by using the framework of Technology Acceptance Model (TAM and its development. The constructs being tested in this research are perceived usefulness, perceived ease of use, experience, social influence, attitute toward behavior, behavioral intention, facilitating condition, and user behaviors. As much as 80 students has been chosen as sample which were determined using purposive sampling method. The data gathered was then analyzed using partial least square (PLS. The result showed that experience did not influence the perceived ease of use, on the other hand perceived usefulness has a positif influence toward users attitude and behavior in using Sikesya, while the perceived ease of use did not influence the users atttitude and  behavior at all, since the students would still use it as it is an application used as part of university services. The attitude and behavior did not influence the behavioral intention, whereas the social influence has a positif effect on behavioral intention, yet the behavioral intention gave positif impact to user’s behavior. On the other hand, facilitating condition has no effect toward users’ behavior.   Keywords: Sharia Financial System (SIKESYA, Technology Acceptance Model (TAM, IAIN Surakarta

  18. Consumers' acceptance of medicinal herbs: An application of the technology acceptance model (TAM).

    Science.gov (United States)

    Jokar, Nargesh Khatun; Noorhosseini, Seyyed Ali; Allahyari, Mohammad Sadegh; Damalas, Christos A

    2017-07-31

    The shift in consumers' preferences from synthetic to 'natural' products has led to a resurgence of interest in medicinal plants, particularly in developing countries. However, research data about consumers' preferences for particular products is hard to find. The main objective of this study was to contribute to the general understanding of consumers' intention for selecting medicinal herbs for consumption. Factors underpinning consumers' acceptance of medicinal herbs were studied with the technology acceptance model (TAM) in Rasht City of Iran using a structured questionnaire. Most respondents had low to moderate familiarity with consumption of medicinal herbs. However, about half of the respondents (47.5%) showed a high level of acceptance of medicinal herbs. Herbs like spearmint (Mentha spicata L.), spinach (Spinacia oleracea L.), basil (Ocimum basilicum L.), Damask rose (Rosa × damascena Herrm.), saffron (Crocus sativus L.), cinnamon (Cinnamomum verum J.Presl), flixweed [Descurainia sophia (L.) Webb ex Prantl], red feathers (Echium amoenum Fisch. & C.A.Mey.), and green tea [Camellia sinensis (L.) Kuntze] had the highest consumption rate among the majority (over 75%) of citizens of Rasht. The highest rate of perceived usefulness of medicinal herbs was related to their perceived role in healing diseases. The variable of importance of use of medicinal herbs had the strongest direct effect and the variables of perceived usefulness and attitude towards use had the second and third strongest direct effect on the acceptance of medicinal herbs' use at p acceptance of medicinal herbs and may serve as a benchmark for future research and evaluation concerning the use of medicinal herbs over time. For plant producers, more effective and targeted crop development should be encouraged, whereas for retailers better marketing and delivery strategies should be sought. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  19. Studying RFID Consumer Acceptance Using TAM: the Case of IUST Students

    Directory of Open Access Journals (Sweden)

    Ahad Zare Ravasan

    2012-02-01

    Full Text Available Radio frequency identification (RFID technology is used in numerous applications and offers a plethora of interesting potential new applications. However, this potential raises issues that require addressing to achieve its widespread acceptance by consumers. This paper investigated the factors that affect consumer acceptance of RFID technology using the technology acceptance model (TAM. To this end, a questionnaire was prepared and distributed among Iran University of Science and Technology (IUST students and gathered data were analyzed using multivariable linear regression method. The results proposed that convenience, culture, and regulation were the principal factors influencing the consumers’ acceptance of RFID. The results of the paper can provide insight to organizations in providing RFID enabled products to their customers and also facilitated its development in the society.

  20. Exploring the Intrinsic Motivation of Hedonic Information Systems Acceptance: Integrating Hedonic Theory and Flow with TAM

    Science.gov (United States)

    Wang, Zhihuan

    Research on Information Systems (IS) acceptance is substantially focused on extrinsic motivation in workplaces, little is known about the underlying intrinsic motivations of Hedonic IS (HIS) acceptance. This paper proposes a hybrid HIS acceptance model which takes the unique characteristics of HIS and multiple identities of a HIS user into consideration by interacting Hedonic theory, Flow theory with Technology Acceptance Model (TAM). The model was empirically tested by a field survey. The result indicates that emotional responses, imaginal responses, and flow experience are three main contributions of HIS acceptance.

  1. Investigating the Effect of Learning Styles in a Blended E-Learning System: An Extension of the Technology Acceptance Model (TAM)

    Science.gov (United States)

    Al-Azawei, Ahmed; Parslow, Patrick; Lundqvist, Karsten

    2017-01-01

    This study assesses learner perceptions of a blended e-learning system (BELS) and the feasibility of accommodating educational hypermedia systems (EHSs) according to learning styles using a modified version of the technology acceptance model (TAM). Recently, Moodle has been adopted by an Iraqi university alongside face-to-face (F2F) classrooms to…

  2. ANALISIS PENERIMAAN E-LEARNING MENGGUNAKAN TECHNOLOGY ACCEPTANCE MODEL (TAM (STUDI KASUS: UNIVERSITAS ATMA JAYA YOGYAKARTA

    Directory of Open Access Journals (Sweden)

    Flourensia Sapty Rahayu

    2017-11-01

    Full Text Available Dalam implementasi sebuah sistem informasi di suatu institusi, perlu dipertimbangkan  bagaimana penerimaan pengguna terhadap sistem informasi tersebut. Penerapan sistem informasi dapat dikatakan gagal jika pengguna ternyata tidak dapat menerima atau tidak mau menggunakan sistem informasi tersebut. Sebagai sebuah institusi pendidikan, Universitas Atma Jaya Yogyakarta (UAJY juga mengimplementasikan sistem e-learning untuk mendukung proses belajar mengajar. Pengguna wajib dari e-learning ini adalah dosen dan mahasiwa. Sejak diterapkan belum pernah diadakan evaluasi mengenai penerimaan pengguna terhdap sistem e-learning ini. Penelitian ini dilakukan untuk melakukan pengujian terhadap penerimaan pengguna (mahasiswa terhadap e-learning dengan menggunakan Technology Acceptance Model (TAM. Pengujian dilakukan dengan mengukur pengaruh antar variabel dalam model TAM yang meliputi variabel Perceived Ease of Use, Perceived Usefulness, Attitude Toward Using, Behavioral Intention dan Actual Usage. Metode pengujian statistik yang dilakukan yaitu uji statistik validitas, reliabilitas, normalitas, dan menguji pengaruh faktor menggunakan Structural Equation Model (SEM. Sumber data didapatkan dengan metode kuesioner yang dibagikan kepada responden mahasiswa UAJY dari seluruh fakultas. Dari enam hipotesis yang diajukan satu hipotesis dinyatakan tidak diterima, yaitu hipotesis yang menyatakan Perceived Usefulnes berpengaruh terhadap Behavioral Intention. Kelima hipotesis yang lain yaitu Perceived Ease of Use berpengaruh terhadap Perceived Usefulnes, Perceived Usefulnes berpengaruh terhadap Attitude Toward Using, Perceived Ease of Use berpengaruh terhadap Attitude Toward Using, Attitude Toward Using berpengaruh terhadap Behavioral Intention, Behavioral Intention berpengaruh terhadap Actual Usage dinyatakan dapat diterima.

  3. PENERAPAN MODIFIKASI TECHNOLOGY ACCEPTANCE MODEL (TAM) DALAM E-BUSINESS

    OpenAIRE

    Adi Setiawan; Lisa Harry Sulistiowati

    2018-01-01

    This study analyzed SMEs batik entrepreneurs in Cirebon to apply e-business. The TAM3 theory is used to create an analytical model in understanding the desires of the entrepreneur. The desire to use technology is due to the perception of the level of ease of use. The easier the user perception, the higher the ability to see the usefulness of technology, and the easier the perception of usage, the higher desire to utilize technology. The analysis result shows that perceived ease of use is in m...

  4. The Technology Acceptance Model for Resource-Limited Settings (TAM-RLS): A Novel Framework for Mobile Health Interventions Targeted to Low-Literacy End-Users in Resource-Limited Settings.

    Science.gov (United States)

    Campbell, Jeffrey I; Aturinda, Isaac; Mwesigwa, Evans; Burns, Bridget; Santorino, Data; Haberer, Jessica E; Bangsberg, David R; Holden, Richard J; Ware, Norma C; Siedner, Mark J

    2017-11-01

    Although mobile health (mHealth) technologies have shown promise in improving clinical care in resource-limited settings (RLS), they are infrequently brought to scale. One limitation to the success of many mHealth interventions is inattention to end-user acceptability, which is an important predictor of technology adoption. We conducted in-depth interviews with 43 people living with HIV in rural Uganda who had participated in a clinical trial of a short messaging system (SMS)-based intervention designed to prompt return to clinic after an abnormal laboratory test. Interviews focused on established features of technology acceptance models, including perceived ease of use and perceived usefulness, and included open-ended questions to gain insight into unexplored issues related to the intervention's acceptability. We used conventional (inductive) and direct content analysis to derive categories describing use behaviors and acceptability. Interviews guided development of a proposed conceptual framework, the technology acceptance model for resource-limited settings (TAM-RLS). This framework incorporates both classic technology acceptance model categories as well as novel factors affecting use in this setting. Participants described how SMS message language, phone characteristics, and experience with similar technologies contributed to the system's ease of use. Perceived usefulness was shaped by the perception that the system led to augmented HIV care services and improved access to social support from family and colleagues. Emergent themes specifically related to mHealth acceptance among PLWH in Uganda included (1) the importance of confidentiality, disclosure, and stigma, and (2) the barriers and facilitators downstream from the intervention that impacted achievement of the system's target outcome. The TAM-RLS is a proposed model of mHealth technology acceptance based upon end-user experiences in rural Uganda. Although the proposed model requires validation, the TAM

  5. Technology, Demographic Characteristics and E-Learning Acceptance: A Conceptual Model Based on Extended Technology Acceptance Model

    Science.gov (United States)

    Tarhini, Ali; Elyas, Tariq; Akour, Mohammad Ali; Al-Salti, Zahran

    2016-01-01

    The main aim of this paper is to develop an amalgamated conceptual model of technology acceptance that explains how individual, social, cultural and organizational factors affect the students' acceptance and usage behaviour of the Web-based learning systems. More specifically, the proposed model extends the Technology Acceptance Model (TAM) to…

  6. SMS Advertising in India: Is TAM a Robust Model for Explaining Intention?

    Directory of Open Access Journals (Sweden)

    Hemant Bamoriya

    2012-06-01

    Full Text Available This study examined mobile users’ intentions to receive SMS advertising in India using Technology Acceptance Model (TAM as research framework. 242 respondents completed a structured questionnaire; measuring their responses for the TAM’s five constructs viz. perceived utility, perceived ease of use, perceived trust, attitude and intention. Using Structural Equation Modeling (SEM both measurement model and structural model testing was done to analyze the data. Findings indicated that specified TAM model contributed to 81.8% of variance in the intention to receive SMS advertising and was a valid model in explaining the intention to receive SMS advertising. Study further indicated that perceived utility was much better predictor of attitude towards SMS advertising than perceived ease of use and perceived trust. Study suggested marketers that to increase acceptance of SMS advertising they should focus more on increasing utility of SMS ads, so that users would develop positive attitudes towards SMS advertising.

  7. Examining the Moderating Effect of Individual-Level Cultural Values on Users' Acceptance of E-Learning in Developing Countries: A Structural Equation Modeling of an Extended Technology Acceptance Model

    Science.gov (United States)

    Tarhini, Ali; Hone, Kate; Liu, Xiaohui; Tarhini, Takwa

    2017-01-01

    In this study, we examine the effects of individual-level culture on the adoption and acceptance of e-learning tools by students in Lebanon using a theoretical framework based on the Technology Acceptance Model (TAM). To overcome possible limitations of using TAM in developing countries, we extend TAM to include "subjective norms" (SN)…

  8. Evaluation of the Acceptance of Audience Response System by Corporations Using the Technology Acceptance Model

    Science.gov (United States)

    Chu, Hsing-Hui; Lu, Ta-Jung; Wann, Jong-Wen

    The purpose of this research is to explore enterprises' acceptance of Audience Response System (ARS) using Technology Acceptance Model (TAM). The findings show that (1) IT characteristics and facilitating conditions could be external variables of TAM. (2) The degree of E-business has positive significant correlation with behavioral intention of employees. (3) TAM is a good model to predict and explain IT acceptance. (4) Demographic variables, industry and firm characteristics have no significant correlation with ARS acceptance. The results provide useful information to managers and ARS providers that (1) ARS providers should focus more on creating different usages to enhance interactivity and employees' using intention. (2) Managers should pay attention to build sound internal facilitating conditions for introducing IT. (3) According to the degree of E-business, managers should set up strategic stages of introducing IT. (4) Providers should increase product promotion and also leverage academic and government to promote ARS.

  9. User Acceptance of Social Learning Systems in Higher Education: An Application of the Extended Technology Acceptance Model

    Science.gov (United States)

    Akman, Ibrahim; Turhan, Cigdem

    2017-01-01

    This study aims to explore the users' behaviour and acceptance of social media for learning in higher educational institutions with the help of the extended Technology Acceptance Model (TAM). TAM has been extended to investigate how ethical and security awareness of users affect the actual usage of social learning applications. For this purpose, a…

  10. An Exploration of Social Networking Sites (SNS) Adoption in Malaysia Using Technology Acceptance Model (TAM), Theory of Planned Behavior (TPB) And Intrinsic Motivation

    OpenAIRE

    Goh Say Leng; Suddin Lada; Mohd Zulkifli Muhammad; Ag Asri Hj Ag Ibrahim; Tamrin Amboala

    2011-01-01

    The objective of the paper is to explore the factors that encourage students to adopt social network sites (SNS) in Malaysia and to use the study’s findings to develop guidelines for SNS providers on how to maximize the rate of adoption. A conceptual model of Technology Acceptance Model (TAM), Theory of Planned Behaviour (TPB) and intrinsic motivation is proposed and empirically tested in the context of SNS usage. Structural Equation modelling was used on the survey data from 283 university s...

  11. The technology acceptance model: its past and its future in health care.

    Science.gov (United States)

    Holden, Richard J; Karsh, Ben-Tzion

    2010-02-01

    Increasing interest in end users' reactions to health information technology (IT) has elevated the importance of theories that predict and explain health IT acceptance and use. This paper reviews the application of one such theory, the Technology Acceptance Model (TAM), to health care. We reviewed 16 data sets analyzed in over 20 studies of clinicians using health IT for patient care. Studies differed greatly in samples and settings, health ITs studied, research models, relationships tested, and construct operationalization. Certain TAM relationships were consistently found to be significant, whereas others were inconsistent. Several key relationships were infrequently assessed. Findings show that TAM predicts a substantial portion of the use or acceptance of health IT, but that the theory may benefit from several additions and modifications. Aside from improved study quality, standardization, and theoretically motivated additions to the model, an important future direction for TAM is to adapt the model specifically to the health care context, using beliefs elicitation methods.

  12. PENERAPAN MODIFIKASI TECHNOLOGY ACCEPTANCE MODEL (TAM DALAM E-BUSINESS

    Directory of Open Access Journals (Sweden)

    Adi Setiawan

    2018-03-01

    Full Text Available This study analyzed SMEs batik entrepreneurs in Cirebon to apply e-business. The TAM3 theory is used to create an analytical model in understanding the desires of the entrepreneur. The desire to use technology is due to the perception of the level of ease of use. The easier the user perception, the higher the ability to see the usefulness of technology, and the easier the perception of usage, the higher desire to utilize technology. The analysis result shows that perceived ease of use is in medium and low category. Perceived usefulness is in the high and medium category. The desire to behavioral intention to use is in the medium and low category. The result of hypothesis testing shows the perception of ease of influence perception of usefulness. Furthermore, perceptions of usefulness affect the desire to use technology in business activities. The test result shows the perception of ease that doesn’t give a direct significant influence to the desire to use technology.

  13. FAKTOR PENENTU MINAT PENGGUNAAN INSTAGRAM UNTUK PEMBELIAN ONLINE MENGGUNAKAN TECHNOLOGY ACCEPTANCE MODEL (TAM DAN THEORY OF PLANNED BEHAVIOR (TPB

    Directory of Open Access Journals (Sweden)

    Bayu Indrayana

    2016-05-01

    Full Text Available The objective of this research is to examine the factors that determine the interest in using Instagram in making online purchases. This study also analyzes the pattern of attitude relationship, subjective norms, behavioral control, and uses on interest in using Instagram for online purchases. In addition, the purpose of the research is to analyze whether there are contributions of usability and convenience toward the attitudes and easiness in using the Instagram toward the usage. Data analysis tool used is the structural equation modeling (SEM which is based technology acceptance model (TAM and theory of planned behavior (TPB. The results showed that subjective norms significantly influence the interest in using Instagram for online purchases; however, behavior control factors, usability and attitude are not significantly influential. Attitude is a factor that has the greatest influence among other factors. Instagram users from companies/businesses that intend to make use of Instagram as their digital marketing media need to pay attention to aspects of attitudes, subjective norms, behavioral control and usability.Key words: model of technology acceptance, consumer behavior, Structural Equation Modelling (SEM, social media

  14. Applying the Technology Acceptance Model and flow theory to Cyworld user behavior: implication of the Web2.0 user acceptance.

    Science.gov (United States)

    Shin, Dong-Hee; Kim, Won-Yong; Kim, Won-Young

    2008-06-01

    This study explores attitudinal and behavioral patterns when using Cyworld by adopting an expanded Technology Acceptance Model (TAM). A model for Cyworld acceptance is used to examine how various factors modified from the TAM influence acceptance and its antecedents. This model is examined through an empirical study involving Cyworld users using structural equation modeling techniques. The model shows reasonably good measurement properties and the constructs are validated. The results not only confirm the model but also reveal general factors applicable to Web2.0. A set of constructs in the model can be the Web2.0-specific factors, playing as enhancing factor to attitudes and intention.

  15. ANALISIS PENERIMAAN PENGGUNAAN OTOMASI PERPUSTAKAAN UNNES BERDASARKAN PENDEKATAN TECHNOLOGY ACCEPTANCE MODEL (TAM

    Directory of Open Access Journals (Sweden)

    Mia Winda Anzaeni

    2017-06-01

    Full Text Available Otomasi Perpustakaan merupakan sistem informasi perpustakaan berbasis web di Universitas Negeri Semarang. Penelitian ini bertujuan untuk mengetahui pengaruh dan menganalisis faktor-faktor yang mempengaruhi penerimaan penggunaan Otomasi Perpustakaan. Pendekatan yang digunakan adalah Technology Acceotance Model (TAM. Populasi dalam penelitian ini adalah mahasiswa pendidikan akuntansi di Universitas Negeri Semarang. Jumlah sampel sebanyak 127 responden. Teknik pengambilan sampel menggunakan non probablity sampling dengan sampling kuota. Metode pengumpulan data menggunakan kuesiioner. Data dianalisis menggunakan teknik path analysis. Hasil penelitian menunjukkan bahwa ada pengaruh positif dan signifikan manfaat (PU terhadap penerimaan (ACC sebesar 24,5%, kemudahan (PEOU terhadap ACC sebesar 24,8%, ATU terhadap ACC sebesar 40,7%, PU terhadap ATU sebesar 25,1%, PEOU terhadap ATU sebesar 24,5%, PU melalui ATU terhadap ACC sebesar 10,2% dan PEOU melalui ATU terhadap ACC sebesar 10%. Berdasarkan penelitian, dapat disimpulkan bahwa terdapat pengaruh perceived usefulness dan perceived ease of use terhadap acceptance baik secara langsung maupun tidak langsung dan pengarung langsung attitude terhadap acceptance. Disarankan kepada pengelola website Otomasi Perpustakaan agar dapat meningkatkan fungsi dari web sehingga pengguna dapat merasakan manfaat dan kemudahan web. Disarankan juga kepada peneliti selanjutnya untuk meneliti dengan objek yang berbeda, serta menambahkan variabel eksternal yang sesuai dengan penelitiannya. Library Automation is a web-based library information systems at the State University of Semarang. This study aims to determine the effect and analyze the factors that affect the acceptance of the use of Library Automation. The population in this research were students of accounting education at State University of Semarang. The total sample of 127 respondents. The sampling technique used is non-probability sampling with quota sampling

  16. Measuring Technology Acceptance Level of Turkish Pre-Service English Teachers by Using Technology Acceptance Model

    Science.gov (United States)

    Kirmizi, Özkan

    2014-01-01

    The aim of this study is to investigate technology acceptance of prospective English teachers by using Technology Acceptance Model (TAM) in Turkish context. The study is based on Structural Equation Model (SEM). The participants of the study from English Language Teaching Departments of Hacettepe, Gazi and Baskent Universities. The participants…

  17. Consumer acceptance of a quick response (QR) code for the food traceability system: Application of an extended technology acceptance model (TAM).

    Science.gov (United States)

    Kim, Yeong Gug; Woo, Eunju

    2016-07-01

    The objectives of this study are to apply the TAM using the addition of perceived information to individuals' behavioral intention to use the QR code for the food traceability system; and to determine the moderating effects of food involvement on the relationship between perceived information and perceived usefulness. Results from a survey of 420 respondents are analyzed using structural equation modeling. The study findings reveal that the extended TAM has a satisfactory fit to the data and that the underlying dimensions have a significant effect on consumers' intention to use the QR code for the food traceability system. In addition, food involvement plays a significant moderating function in the relationship between perceived information and perceived usefulness. The implications of this study for future research are discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Explaining the Discrepancy in the Mediating Role of Attitude in the TAM

    Science.gov (United States)

    López-Bonilla, Luis Miguel; López-Bonilla, Jesús Manuel

    2017-01-01

    The debate about the role of attitude in the technology acceptance model (TAM) seems to have re-emerged in two prestigious journals in the field of educational technology. Among the publications on this debate, there are authors in favour of excluding the attitude of TAM, whereas others are in favour of including it. These opinions are derived…

  19. User Acceptance of the Intranet in Restaurant Franchise Systems: An Empirical Study

    OpenAIRE

    Park, Kunsoon

    2006-01-01

    This research study examined the acceptance of the intranet in restaurant franchise systems. The widely accepted Technology Acceptance Model (TAM) developed by Davis (1986, 1989) was the basis for this study. TAM is an excellent model to predict information technology (IT) usage and is based on the Theory of Reasoned Action (TRA). Therefore, TAM was adopted in this study of intranet acceptance. Furthermore, this study attempted to see if the earlier results of TAM are still valid. The origina...

  20. Applying the Extended Technology Acceptance Model to the Use of Clickers in Student Learning: Some Evidence from Macroeconomics Classes

    Science.gov (United States)

    Wu, Xiaoyu; Gao, Yuan

    2011-01-01

    This paper applies the extended technology acceptance model (exTAM) in information systems research to the use of clickers in student learning. The technology acceptance model (TAM) posits that perceived ease of use and perceived usefulness of technology influence users' attitudes toward using and intention to use technology. Research subsequent…

  1. Chinese Nurses' Acceptance of PDA: A Cross-Sectional Survey Using a Technology Acceptance Model.

    Science.gov (United States)

    Wang, Yanling; Xiao, Qian; Sun, Liu; Wu, Ying

    2016-01-01

    This study explores Chinese nurses' acceptance of PDA, using a questionnaire based on the framework of Technology Acceptance Model (TAM). 357 nurses were involved in the study. The results reveal the scores of the nurses' acceptance of PDA were means 3.18~3.36 in four dimensions. The younger of nurses, the higher nurses' title, the longer previous usage time, the more experienced using PDA, and the more acceptance of PDA. Therefore, the hospital administrators may change strategies to enhance nurses' acceptance of PDA, and promote the wide application of PDA.

  2. Uno strumento di misurazione delle abilita metalinguistiche: il T.A.M. (An Instrument to Measure Metalinguistic Abilities: The T.A.M.).

    Science.gov (United States)

    Pinto, Maria Antonietta; Titone, Renzo

    1989-01-01

    Discusses the development, administration, and evaluation of the Test of Metalinguistic Ability (TAM). Developed at the University of Rome, the TAM consists of 96 items divided into 6 parts: comprehension, synonyms, acceptability, ambiguity, grammatical function, and phonemic segmentation. (CFM)

  3. Assessing the utility of TAM, TPB, and UTAUT for advanced driver assistance systems.

    Science.gov (United States)

    Rahman, Md Mahmudur; Lesch, Mary F; Horrey, William J; Strawderman, Lesley

    2017-11-01

    Advanced Driver Assistance Systems (ADAS) are intended to enhance driver performance and improve transportation safety. The potential benefits of these technologies, such as reduction in number of crashes, enhancing driver comfort or convenience, decreasing environmental impact, etc., have been acknowledged by transportation safety researchers and federal transportation agencies. Although these systems afford safety advantages, they may also challenge the traditional role of drivers in operating vehicles. Driver acceptance, therefore, is essential for the implementation of these systems into the transportation system. Recognizing the need for research into the factors affecting driver acceptance, this study assessed the utility of the Technology Acceptance Model (TAM), the Theory of Planned Behavior (TPB), and the Unified Theory of Acceptance and Use of Technology (UTAUT) for modelling driver acceptance in terms of Behavioral Intention to use an ADAS. Each of these models propose a set of factors that influence acceptance of a technology. Data collection was done using two approaches: a driving simulator approach and an online survey approach. In both approaches, participants interacted with either a fatigue monitoring system or an adaptive cruise control system combined with a lane-keeping system. Based on their experience, participants responded to several survey questions to indicate their attitude toward using the ADAS and their perception of its usefulness, usability, etc. A sample of 430 surveys were collected for this study. Results found that all the models (TAM, TPB, and UTAUT) can explain driver acceptance with their proposed sets of factors, each explaining 71% or more of the variability in Behavioral Intention. Among the models, TAM was found to perform the best in modelling driver acceptance followed by TPB. The findings of this study confirm that these models can be applied to ADAS technologies and that they provide a basis for understanding driver

  4. A meta-analysis of the technology acceptance model : investigating subjective norm and moderation effects

    NARCIS (Netherlands)

    Schepers, J.J.L.; Wetzels, M.G.M.

    2007-01-01

    We conducted a quantitative meta-analysis of previous research on the technology acceptance model (TAM) in an attempt to make well-grounded statements on the role of subjective norm. Furthermore, we compared TAM results by taking into account moderating effects of one individual-related factor (type

  5. Dialectic Antidotes to Critics of the Technology Acceptance Model: Conceptual, Methodological, and Replication Treatments for Behavioural Modelling in Technology-Mediated Environments

    Directory of Open Access Journals (Sweden)

    Weng Marc Lim

    2018-01-01

    Full Text Available The technology acceptance model (TAM is a prominent and parsimonious conceptual lens that is often applied for behavioural modelling in technology-mediated environments. However, TAM has received a great deal of criticism in recent years. This article aims to address some of the most pertinent issues confronting TAM through a rejoinder that offers dialectic antidotes—in the form of conceptual, methodological, and replication treatments—to support the continued use of TAM to understand the peculiarities of user interactions with technology in technology-mediated environments. In doing so, this article offers a useful response to a common but often inadequately answered question about how TAM can continue to be relevant for behavioural modelling in contemporary technology-mediated environments.

  6. Online Marketing Enterprise of Jombang Culinary from TAM and VEM Perspective on Social Media

    Directory of Open Access Journals (Sweden)

    nuri purwanto

    2017-11-01

    Full Text Available The purpose of this research was to develop, evaluate, and test antecedent model with trust as an intermediary variable of Technology Acceptances Model (TAM and Virtual Experiential Marketing (VEM for buying intention. It used purposive sampling technique with 300 respondents. The questionnaire results were evaluated and analyzed using Structural Equation Model (SEM method with the analysis tools (the third version of SmartPLS. The research result shows that there is no effect between TAM and trust. In addition, there is a direct and positive influence of VEM on trust. The trust and TAM have a positive effect on buying intention. However, VEM does not affect buying intention. The results indicate that the trust cannot mediate TAM and buying intention. Meanwhile, trust can mediate between VEM and buying intention.

  7. THE USE OF INFORMATION COMMUNICATION TECHNOLOGY (ICT AS THE TECHNOLOGY ACCEPTANCE MODEL (TAM OF MOBILE BANKING

    Directory of Open Access Journals (Sweden)

    Paulus Yokie Radnan

    2018-01-01

    Full Text Available Information Technology services in banking business which is very dynamic and advanced makes the bankers must adjust to the presence of this technology. In this paper, the authors will explain the role of Mobile banking technology which is provided by CIMB Niaga in servicing its customers for banking transactions. The methodology used in this paper is quantitative with the purposive sampling one. Instrument used the Technology Acceptance Model (TAM as developed by Parasuraman and Davis by modifying them to fit the state of the research object. This research was conducted in Jakarta and several other places. Research and data collection took 6 months from November 2015 to April 2016. The variables included trust, perceived use (PU, perceived ease of use (PEU, attitude toward use (ATU, Intent to use (ITU, and actual use (AU. After the data were collected, the regression analysis was performed. From the analysis result it was found that trust and perceived use (PU variables did not positively and significantly influence the intent to use (ITU variable, as well as the perceived use variables (PU and perceived ease of use (PEU which have no significant and positive effect on attitude variable on usage (ATU. For that case, the authors propose an improvement strategy to maintain and grow this business forward.

  8. Identifying Ghanaian Pre-Service Teachers' Readiness for Computer Use: A Technology Acceptance Model Approach

    Science.gov (United States)

    Gyamfi, Stephen Adu

    2016-01-01

    This study extends the technology acceptance model to identify factors that influence technology acceptance among pre-service teachers in Ghana. Data from 380 usable questionnaires were tested against the research model. Utilising the extended technology acceptance model (TAM) as a research framework, the study found that: pre-service teachers'…

  9. Validating the Technology Acceptance Model in the Context of the Laboratory Information System-Electronic Health Record Interface System

    Science.gov (United States)

    Aquino, Cesar A.

    2014-01-01

    This study represents a research validating the efficacy of Davis' Technology Acceptance Model (TAM) by pairing it with the Organizational Change Readiness Theory (OCRT) to develop another extension to the TAM, using the medical Laboratory Information Systems (LIS)--Electronic Health Records (EHR) interface as the medium. The TAM posits that it is…

  10. Examining Engineering & Technology Students' Acceptance of Network Virtualization Technology Using the Technology Acceptance Model

    Science.gov (United States)

    Yousif, Wael K.

    2010-01-01

    This causal and correlational study was designed to extend the Technology Acceptance Model (TAM) and to test its applicability to Valencia Community College (VCC) Engineering and Technology students as the target user group when investigating the factors influencing their decision to adopt and to utilize VMware as the target technology. In…

  11. The acceptance and use of a virtual learning environment in China

    NARCIS (Netherlands)

    Raaij, van E.M.; Schepers, J.J.L.

    2008-01-01

    The success of a virtual learning environment (VLE) depends to a considerable extent on student acceptance and use of such an e-learning system. After critically assessing models of technology adoption, including the Technology Acceptance Model (TAM), TAM2, and the Unified Theory of Acceptance and

  12. Kajian Penerimaan Pengguna Terhadap Sistem CRM di Perusahaan X Menggunakan Model TAM

    Directory of Open Access Journals (Sweden)

    Muhammad Malik Hakim

    2018-03-01

    Full Text Available Pelayanan kepada pelanggan adalah salah satu tujuan bisnis setiap perusahaan dalam upayanya memberikan kepuasan kepada para pelanggannya. Untuk mengintegrasikan seluruh kegiatan pelayanan kepada pelanggan dari semua divisi yang terkait baik langsung maupun tidak langsung, Perusahaan X sebagai perusahaan yang bergerak dalam bidang TI telah mengimplementasikan sistem CRM (Customer Relationship Management. Implementasi CRM tersebut bertujuan untuk mensinergikan kegiatan pelayanan kepada pelanggan agar tidak saling tumpang tindih dan dapat terkoordinasi dengan baik. Untuk mendukung kesuksesan dan keberlanjutan penggunaan sistem CRM, penelitian ini mengkaji penerimaan pengguna sistem CRM di antara semua karyawan dalam divisi terkait di dalam perusahaan yang berjumlah 141 orang, menggunakan Model TAM (Technology Acceptance Model yang dimodifikasi, yaitu tanpa melibatkan variabel eksternal. Penelitian ini mengkaji penerimaan pengguna berdasarkan empat variabel penyusun Model TAM, yaitu Perceived Ease Of Use (PEOU, Perceived Usefulness (PU, Behavioral Intention (BI, dan Actual Use (AU. Studi membuktikan bahwa diperoleh pengaruh yang positif dan signifikan antara variabel – variabel penyusunnya, yaitu PEOU terhadap PU dan BI, PU terhadap BI, serta BI terhadap AU dengan nilai pengaruh masing – masing adalah 0,43; 0,67; 0,58; dan 0,77. Penelitian ini membuktikan bahwa penerimaan pengguna CRM sangat dipengaruhi oleh faktor manfaat, kemudahan, serta perilaku karyawan dalam menggunakannya.

  13. [The Technology Acceptance Model and Its Application in a Telehealth Program for the Elderly With Chronic Illnesses].

    Science.gov (United States)

    Chang, Chi-Ping

    2015-06-01

    Many technology developments hold the potential to improve the quality of life of people and make life easier and more comfortable. New technologies have been well accepted by most people. Information sharing in particular is a major catalyst of change in our current technology-based society. Technology has widely innovated life and drastically changed lifestyles. The Technology Acceptance Model (TAM), a model developed to address the rapid advances in computer technology, is used to explain and predict user acceptance of new information technology. In the past, businesses have used the TAM as an assessment tool to predict user acceptance when introducing new technology products. They have also used external factors in the model to influence user perceptions and beliefs and to ensure the successful spread of new technologies. Informatization plays a critical role in healthcare services. Due to the rapid aging of populations and upward trends in the incidence of chronic illness, requirements for long-term care have increased in both quality and quantity. Therefore, there has been an increased emphasis on integrating healthcare and information technology. However, most elderly are significantly less adept at technology use than the general population. Therefore, we reexamined the effect that the essential concepts in a TAM exerted on technology acceptance. In the present study, the technology acceptance experience with regard to telehealth of the elderly was used as an example to explain how the revised technology acceptance model (TAM 2) may be effectively applied to enhance the understanding of technology care among nurses. The results may serve as a reference for future research on healthcare-technology use in long-term care or in elderly populations.

  14. The Development of a Competency Testing Systems: Adopting TAM to Explore User’s Acceptance

    Directory of Open Access Journals (Sweden)

    Ibrahim Wahyu Saputra

    2017-12-01

    Full Text Available The main problems of learning evaluation using paper based-test are inefficient time and cost. Technology can be used as a system to evaluate the learning process. Using technology can save time and cost of implementing learning evaluations. The aims of this study are to create a software product that can be used to evaluate the learning process. This software product is designed to be used by the test organizer or test committee, the teachers and the students (test takers. This software product was developed using Waterfall Model with five stages of development; communication, planning, modeling, construction, and deployment. The testing was conducted by using Blackbox Method and TAM Theory by considering the aspect of usefulness and the aspect ease of use. The analysis was based on the flow of the current test system. The web-based platform enables ease of access for conducting work in various places. According to the result, the Developed Skills Competency Test System is accepted and can be used by the user as an evaluation system.

  15. Acceptance of health information technology in health professionals: an application of the revised technology acceptance model.

    Science.gov (United States)

    Ketikidis, Panayiotis; Dimitrovski, Tomislav; Lazuras, Lambros; Bath, Peter A

    2012-06-01

    The response of health professionals to the use of health information technology (HIT) is an important research topic that can partly explain the success or failure of any HIT application. The present study applied a modified version of the revised technology acceptance model (TAM) to assess the relevant beliefs and acceptance of HIT systems in a sample of health professionals (n = 133). Structured anonymous questionnaires were used and a cross-sectional design was employed. The main outcome measure was the intention to use HIT systems. ANOVA was employed to examine differences in TAM-related variables between nurses and medical doctors, and no significant differences were found. Multiple linear regression analysis was used to assess the predictors of HIT usage intentions. The findings showed that perceived ease of use, but not usefulness, relevance and subjective norms directly predicted HIT usage intentions. The present findings suggest that a modification of the original TAM approach is needed to better understand health professionals' support and endorsement of HIT. Perceived ease of use, relevance of HIT to the medical and nursing professions, as well as social influences, should be tapped by information campaigns aiming to enhance support for HIT in healthcare settings.

  16. User Acceptance of YouTube for Procedural Learning: An Extension of the Technology Acceptance Model

    Science.gov (United States)

    Lee, Doo Young; Lehto, Mark R.

    2013-01-01

    The present study was framed using the Technology Acceptance Model (TAM) to identify determinants affecting behavioral intention to use YouTube. Most importantly, this research emphasizes the motives for using YouTube, which is notable given its extrinsic task goal of being used for procedural learning tasks. Our conceptual framework included two…

  17. Evaluation of teledermatology adoption by health-care professionals using a modified Technology Acceptance Model.

    Science.gov (United States)

    Orruño, Estibalitz; Gagnon, Marie Pierre; Asua, José; Ben Abdeljelil, Anis

    2011-01-01

    We examined the main factors affecting the intention of physicians to use teledermatology using a modified Technology Acceptance Model (TAM). The investigation was carried out during a teledermatology pilot study conducted in Spain. A total of 276 questionnaires were sent to physicians by email and 171 responded (62%). Cronbach's alpha was acceptably high for all constructs. Theoretical variables were well correlated with each other and with the dependent variable (Intention to Use). Logistic regression indicated that the original TAM model was good at predicting physicians' intention to use teledermatology and that the variables Perceived Usefulness and Perceived Ease of Use were both significant (odds ratios of 8.4 and 7.4, respectively). When other theoretical variables were added, the model was still significant and it also became more powerful. However, the only significant predictor in the modified model was Facilitators with an odds ratio of 9.9. Thus the TAM was good at predicting physicians' intention to use teledermatology. However, the most important variable was the perception of Facilitators to using the technology (e.g. infrastructure, training and support).

  18. Perceived Convenience in an Extended Technology Acceptance Model: Mobile Technology and English Learning for College Students

    Science.gov (United States)

    Chang, Chi-Cheng; Yan, Chi-Fang; Tseng, Ju-Shih

    2012-01-01

    Since convenience is one of the features for mobile learning, does it affect attitude and intention of using mobile technology? The technology acceptance model (TAM), proposed by David (1989), was extended with perceived convenience in the present study. With regard to English language mobile learning, the variables in the extended TAM and its…

  19. Development of Test-Analysis Models (TAM) for correlation of dynamic test and analysis results

    Science.gov (United States)

    Angelucci, Filippo; Javeed, Mehzad; Mcgowan, Paul

    1992-01-01

    The primary objective of structural analysis of aerospace applications is to obtain a verified finite element model (FEM). The verified FEM can be used for loads analysis, evaluate structural modifications, or design control systems. Verification of the FEM is generally obtained as the result of correlating test and FEM models. A test analysis model (TAM) is very useful in the correlation process. A TAM is essentially a FEM reduced to the size of the test model, which attempts to preserve the dynamic characteristics of the original FEM in the analysis range of interest. Numerous methods for generating TAMs have been developed in the literature. The major emphasis of this paper is a description of the procedures necessary for creation of the TAM and the correlation of the reduced models with the FEM or the test results. Herein, three methods are discussed, namely Guyan, Improved Reduced System (IRS), and Hybrid. Also included are the procedures for performing these analyses using MSC/NASTRAN. Finally, application of the TAM process is demonstrated with an experimental test configuration of a ten bay cantilevered truss structure.

  20. Development of a health information technology acceptance model using consumers' health behavior intention.

    Science.gov (United States)

    Kim, Jeongeun; Park, Hyeoun-Ae

    2012-10-01

    For effective health promotion using health information technology (HIT), it is mandatory that health consumers have the behavioral intention to measure, store, and manage their own health data. Understanding health consumers' intention and behavior is needed to develop and implement effective and efficient strategies. To develop and verify the extended Technology Acceptance Model (TAM) in health care by describing health consumers' behavioral intention of using HIT. This study used a cross-sectional descriptive correlational design. We extended TAM by adding more antecedents and mediating variables to enhance the model's explanatory power and to make it more applicable to health consumers' behavioral intention. Additional antecedents and mediating variables were added to the hypothetical model, based on their theoretical relevance, from the Health Belief Model and theory of planned behavior, along with the TAM. We undertook structural equation analysis to examine the specific nature of the relationship involved in understanding consumers' use of HIT. Study participants were 728 members recruited from three Internet health portals in Korea. Data were collected by a Web-based survey using a structured self-administered questionnaire. The overall fitness indices for the model developed in this study indicated an acceptable fit of the model. All path coefficients were statistically significant. This study showed that perceived threat, perceived usefulness, and perceived ease of use significantly affected health consumers' attitude and behavioral intention. Health consumers' health status, health belief and concerns, subjective norm, HIT characteristics, and HIT self-efficacy had a strong indirect impact on attitude and behavioral intention through the mediators of perceived threat, perceived usefulness, and perceived ease of use. An extended TAM in the HIT arena was found to be valid to describe health consumers' behavioral intention. We categorized the concepts in

  1. Acceptance of health information technology in health professionals: An application of the revised technology acceptance model

    OpenAIRE

    Ketikidis, P.; Dimitrovski, T.; Lazuras, L.; Bath, P.A.

    2012-01-01

    The response of health professionals to the use of health information technology (HIT) is an important research topic that can partly explain the success or failure of any HIT application. The present study applied a modified version of the revised technology acceptance model (TAM) to assess the relevant beliefs and acceptance of HIT systems in a sample of health professionals (n = 133). Structured anonymous questionnaires were used and a cross-sectional design was employed. The main outcome ...

  2. Analisis Sikap Pengguna Paytren Menggunakan Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Moh Siri

    2017-04-01

    Full Text Available Abstrak Semakin pesatnya aplikasi berbasis android mendorong masyarakat beralih dan menggunakan. Melakukan transaksi dan pembayaran ke loket-loket Paymen Point Online Bank (BPOB yang dirasa kurang membantu masyarakat dalam kegiatan transkasi. Oleh karenanya hadir sebuah layanan terknologi dibidang micropayment dengan perangkat lunak bernama PayTren yang dapat digunakan untuk pembayaran transaksi dalam jumlah kecil  (micropayment berbasis android yang merupakan salah satu alternatif tepat dan bermanfaat untuk sarana mempermudah pengguna dalam melakukan transaksi atau pembayaran serta mampu menggeser jenis pembayaran pada loket-loket pembayaran pada umumnya. Tujuan dalam penelitian ini adalah untuk menganalisis sikap pengguna aplikasi PayTren berbasis android dengan menggunakan metode Technology Acceptance Model (TAM, serta pengujian menggunakan analisis regresi. Manfaat penelitian ini adalah sebagai referensi untuk penelitian selanjutnya dengan menggunakan metode TAM dan ditambahkan variabel yang lain. Hasil dari penelitian ini persepsi kegunaan (perceived usefullness dan persepi kemudahan (perceived easy of use memiliki pengaruh yang dikategorikan kuat dan lemah terhadap (attitude toward using sikap pengguna. Kata Kunci: Aplikasi, Android, PayTren, Technology Acceptance Model.                                                                                                                             Abstract The more rapid the android-based applications are pushing the community move on and use. Transaction and payment to the counter-the counter of Paymen Point Online Bank (BPOB where less help the community in dealings. Therefore present a terknologi service in the field of micropayment with software called PayTren that can be used for payment transactions in small amounts (micropayment android-based which is one of the alternatives is right and beneficial for the means of

  3. Examining the antecedents of Facebook acceptance via structural equation modeling: A case of CEGEP students

    Directory of Open Access Journals (Sweden)

    Tenzin Doleck

    2017-03-01

    Full Text Available Although the last decade has witnessed social networking sites of varied flavors, Facebook’s user growth continues to balloon, and relatedly, Facebook remains popular among the college populace. While there has been a growing body of work on ascertaining antecedents of Facebook use among college students, Collège d'enseignement général et professionnel (CEGEP students’ acceptance of Facebook remains underexplored. The purpose of this study was to analyze CEGEP students’ acceptance of Facebook using the technology acceptance model (TAM. Structural equation modeling was conducted on data from a survey of 214 CEGEP students. We find that Facebook use is motivated by the core TAM constructs as well as the added factors of peer influence, perceived enjoyment, perceived self-efficacy, relative advantage, risk, and trust.

  4. Determinasi Faktor-Faktor Keamanan E-Banking Terhadap Kepercayaan dengan Pendekatan Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    M. Haris Qamaruzzaman

    2014-01-01

    Full Text Available Safety  and  convenience  factor  is  important  for  confidence  in  the  use  of  e-banking.  This  study  aimed  to  investigate  the  factors determination  using  e-banking  approach  to  technology  acceptance  model,  and  analyze  the  determination  of  the  factors  the  use  of  ebanking  with  the  Technology  Acceptance  Model  approach.  Technology  Acceptance  Model  (TAM  is  a  model  used  to  explain  the acceptance of the technology to be used by users of the technology. In the context of this study, TAM raises the safety factor and the factor of ease of use of e-banking to e-banking trust uses. This research is a field research (field research with a quantitative approach that examines the issues being studied. Sampling method using random sampling technique as much as 100 respondents. Data collection techniques are the primary data by distributing questionnaires to the users e-banking. While the secondary data that other reports related to research. The data analysis techniques used include descriptive statistics and analysis phases of statistical regression analysis. These results prove that the safety factor has a significant and positive effect on user confidence in e-banking proven Ho is rejected and Ha accepted  with  a  significance  level  of  0.001  (<0.05,  while  the  convenience  factor  also  has  a  positive  and  significant  impact  on  user confidence in e-banking proven Ho is rejected and Ha accepted with a significance level of 0.000 (<0.05.Keywords: Factor Security; Ease; Confidence Use of e-banking; Technology Acceptance Model (TAM

  5. Adding Innovation Diffusion Theory to the Technology Acceptance Model: Supporting Employees' Intentions to Use E-Learning Systems

    Science.gov (United States)

    Lee, Yi-Hsuan; Hsieh, Yi-Chuan; Hsu, Chia-Ning

    2011-01-01

    This study intends to investigate factors affecting business employees' behavioral intentions to use the e-learning system. Combining the innovation diffusion theory (IDT) with the technology acceptance model (TAM), the present study proposes an extended technology acceptance model. The proposed model was tested with data collected from 552…

  6. Examining Information Technology Acceptance by Individual Professionals

    Directory of Open Access Journals (Sweden)

    Licen Indahwati Darsono

    2005-06-01

    Full Text Available The mixed results of information technology (IT investment have made the investigation of user acceptance of IT increasingly challenging. A growing body of research in user acceptance of IT literature has limited focus on individual professionals as target users. Therefore, this research investigates how external variables, namely individual differences and system characteristics influence lecturers as individual professionals to accept the internet technology. Technology Acceptance Model (TAM and Theory of Planned Behavior (TPB are used as the main reference in this research. Findings of this research indicate that individual differences (computer self-efficacy, knowledge of search domain and system characteristics (terminology, screen design, relevance have indirect impact through perceived ease of use, perceived usefulness, and attitude on lecturers’ intention to use the internet. Specifically, computer self-efficacy and screen design have direct and indirect impact on intention. One issue concerning with the explanatory power of the proposed research model, which is based on TAM and TPB, compared to the rival model, which is called extended TAM, is also analyzed.

  7. Empirical investigation of e-learning acceptance and assimilation: A structural equation model

    Directory of Open Access Journals (Sweden)

    Said S. Al-Gahtani

    2016-01-01

    Full Text Available E-learning has become progressively more vital for academia and corporate training and has potentially become one of the most significant developments and applications in Information Technologies (ITs. This study used a quantitative approach seeking a causative explanation of the decision behavior of individuals toward the acceptance and assimilation of e-learning in academic settings. A survey of 286 participants (students was conducted to collect the research data. Our study framework was based on the third version of the Technology Acceptance Model (i.e., TAM3 and the data were analyzed using structural equation modeling in order to determine the factors that influence the learners’ intention to use e-learning. Results show the predicting (promoting/inhibiting factors of e-learning technology acceptance, while also examining some related post-implementation interventions expected to contribute to the acceptance and assimilation of e-learning systems. Our results also indicate that TAM3 holds well in the Arabian culture and also outline valuable outcomes such as: managerial interventions and controls for better organizational e-learning management that can lead to greater acceptance and effective utilization. Hopefully, this study provides a roadmap to more understanding of the success factors and post-implementation interventions contributing to the acceptance and assimilation of e-learning systems in developing countries.

  8. An Evaluation of GeoBEST Contingency Beddown Planning Software Using the Technology Acceptance Model

    National Research Council Canada - National Science Library

    Jensen, Shawn

    2002-01-01

    .... The Technology Acceptance Model (TAM) was applied, which measures a prospective user's perceptions of the technology's usefulness and ease-of-use and predicts their intentions to use the software in the future...

  9. Acceptance of Internet Banking Systems among Young Managers

    International Nuclear Information System (INIS)

    Ariff, Mohd Shoki Md; Yeow S M; Zakuan, Norhayati; Bahari, Ahamad Zaidi

    2013-01-01

    The aim of this paper is to determine acceptance of internet banking system among potential young users, specifically future young managers. The relationships and the effects of computer self-efficacy (CSE) and extended technology acceptance model (TAM) on the behavioural intention (BI) to use internet banking system were examined. Measurement of CSE, TAM and BI were adapted from previous studies. However construct for TAM has been extended by adding a new variable which is perceived credibility (PC). A survey through questionnaire was conducted to determine the acceptance level of CSE, TAM and BI. Data were obtained from 275 Technology Management students, who are pursuing their undergraduate studies in a Malaysia's public university. The confirmatory factor analysis performed has identified four variables as determinant factors of internet banking acceptance. The first variable is computer self-efficacy (CSE), and another three variables from TAM constructs which are perceived usefulness (PU), perceived ease of use (PE) and perceived credibility (PC). The finding of this study indicated that CSE has a positive effect on PU and PE of the Internet banking systems. Respondents' CSE was positively affecting their PC of the systems, indicating that the higher the ability of one in computer skills, the higher the security and privacy issues of PC will be concerned. The multiple regression analysis indicated that only two construct of TAM; PU and PC were significantly associated with BI. It was found that the future managers' CSE indirectly affects their BI to use the internet banking systems through PU and PC of TAM. TAM was found to have direct effects on respondents' BI to use the systems. Both CSE and the PU and PC of TAM were good predictors in understanding individual responses to information technology. The role of PE of the original TAM to predict the attitude of users towards the use of information technology systems was surprisingly insignificant.

  10. Acceptance of Internet Banking Systems among Young Managers

    Science.gov (United States)

    Ariff, Mohd Shoki Md; M, Yeow S.; Zakuan, Norhayati; Zaidi Bahari, Ahamad

    2013-06-01

    The aim of this paper is to determine acceptance of internet banking system among potential young users, specifically future young managers. The relationships and the effects of computer self-efficacy (CSE) and extended technology acceptance model (TAM) on the behavioural intention (BI) to use internet banking system were examined. Measurement of CSE, TAM and BI were adapted from previous studies. However construct for TAM has been extended by adding a new variable which is perceived credibility (PC). A survey through questionnaire was conducted to determine the acceptance level of CSE, TAM and BI. Data were obtained from 275 Technology Management students, who are pursuing their undergraduate studies in a Malaysia's public university. The confirmatory factor analysis performed has identified four variables as determinant factors of internet banking acceptance. The first variable is computer self-efficacy (CSE), and another three variables from TAM constructs which are perceived usefulness (PU), perceived ease of use (PE) and perceived credibility (PC). The finding of this study indicated that CSE has a positive effect on PU and PE of the Internet banking systems. Respondents' CSE was positively affecting their PC of the systems, indicating that the higher the ability of one in computer skills, the higher the security and privacy issues of PC will be concerned. The multiple regression analysis indicated that only two construct of TAM; PU and PC were significantly associated with BI. It was found that the future managers' CSE indirectly affects their BI to use the internet banking systems through PU and PC of TAM. TAM was found to have direct effects on respondents' BI to use the systems. Both CSE and the PU and PC of TAM were good predictors in understanding individual responses to information technology. The role of PE of the original TAM to predict the attitude of users towards the use of information technology systems was surprisingly insignificant.

  11. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.

    Science.gov (United States)

    Lew, Erin D; Oh, Jennifer; Burrola, Patrick G; Lax, Irit; Zagórska, Anna; Través, Paqui G; Schlessinger, Joseph; Lemke, Greg

    2014-09-29

    The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineate the rules for TAM receptor-ligand engagement and find that the TAMs segregate into two groups based on ligand specificity, regulation by phosphatidylserine, and function. Tyro3 and Mer are activated by both ligands but only Gas6 activates Axl. Optimal TAM signaling requires coincident TAM ligand engagement of both its receptor and the phospholipid phosphatidylserine (PtdSer): Gas6 lacking its PtdSer-binding 'Gla domain' is significantly weakened as a Tyro3/Mer agonist and is inert as an Axl agonist, even though it binds to Axl with wild-type affinity. In two settings of TAM-dependent homeostatic phagocytosis, Mer plays a predominant role while Axl is dispensable, and activation of Mer by Protein S is sufficient to drive phagocytosis.

  12. An Analysis of Technology Acceptance in Turkey using Fuzzy Logic and Structural Equation Modelling

    Directory of Open Access Journals (Sweden)

    Bilgin Şenel

    2011-12-01

    Full Text Available Technology is in a constant progress in the way of satisfying increasing human needs. This fact will hold true for the years to come. However, the level of adaptation to technological advancements varies greatly across countries. The pace of adjustment is directly proportional to the importance attached to and the funds allocated for this purpose. Despite the abundance of technological investments in Turkey in recent years, there are only a few studies analyzing the current level of individual interest in technology. This study therefore aims to determine the technology acceptance of Turkish people by using the Technology Acceptance Model (TAM developed by Davis (1989 and to demonstrate the reasons to accept or not accept technology departing from the links between dimensions. While accomplishing this aim, Structural Equation Model (SEM that is a highly strong multivariable analysis technique that makes possible the evaluation of latent structures like psychosocial needs, and the Fuzzy Logic Theorem that provides strong and significant instruments for the measurement of ambiguities and provides the opportunity to meaningfully represent ambiguous concepts expressed in the natural language were used. According to the findings of this study, it was determined that the perceived ease of use is more influential in people’s acceptance of technology than the perceived usefulness is. It was also found that technology acceptance does not differ significantly at the statistical significance level of 0.05 with respect to the participants’ demographic characteristics (age, gender, education level, hometown etc.. In addition, analyses performed to define the relationships between the dimensions of the TAM yielded results that highly supported the TAM. In other words, the dimensions affect technology acceptance to positive and significant degrees

  13. Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

    Science.gov (United States)

    Lew, Erin D; Oh, Jennifer; Burrola, Patrick G; Lax, Irit; Zagórska, Anna; Través, Paqui G; Schlessinger, Joseph; Lemke, Greg

    2014-01-01

    The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineate the rules for TAM receptor–ligand engagement and find that the TAMs segregate into two groups based on ligand specificity, regulation by phosphatidylserine, and function. Tyro3 and Mer are activated by both ligands but only Gas6 activates Axl. Optimal TAM signaling requires coincident TAM ligand engagement of both its receptor and the phospholipid phosphatidylserine (PtdSer): Gas6 lacking its PtdSer-binding ‘Gla domain’ is significantly weakened as a Tyro3/Mer agonist and is inert as an Axl agonist, even though it binds to Axl with wild-type affinity. In two settings of TAM-dependent homeostatic phagocytosis, Mer plays a predominant role while Axl is dispensable, and activation of Mer by Protein S is sufficient to drive phagocytosis. DOI: http://dx.doi.org/10.7554/eLife.03385.001 PMID:25265470

  14. The limitations of using the existing TAM in adoption of clinical decision support system in hospitals: An empirical study in Malaysia

    Directory of Open Access Journals (Sweden)

    Pouyan Esmaeilzadeh

    2014-04-01

    Full Text Available The technology acceptance model (TAM has been widely used to study user acceptance of new computer technologies. Previous studies claimed that future technology acceptance research should explore other additional explanatory variables, which may affect the originally proposed constructs of the TAM. The use of information technology in the health care sector and especially in hospitals offers great potential for improving the performance of physicians, increasing the quality of services and also reducing the organizational expenses. However, the main challenge that arises according to the literature is whether healthcare professionals are willing to adopt and use clinical information technology while performing their tasks. Although adoption of various information technologies has been studied using the technology acceptance model (TAM, the study of technology acceptance for professional groups (such as physicians has been limited. Physician adoption of clinical information technology is important for its successful implementation. Therefore, the purpose of this study is to gain a better insight about factors affecting physicians’ acceptance of clinical decision support systems (CDSS in a hospital setting. The results reflect the importance of perceived threat to professional autonomy, perceived interactivity with clinical IT, perceived usefulness and perceived ease of use in determining physicians’ intention to use CDSS.

  15. Facile and High-Yielding Synthesis of TAM Biradicals and Monofunctional TAM Radicals.

    Science.gov (United States)

    Trukhin, Dmitry V; Rogozhnikova, Olga Yu; Troitskaya, Tatiana I; Vasiliev, Vladimir G; Bowman, Michael K; Tormyshev, Victor M

    2016-04-01

    Facile and high-yielding procedures for synthesis of monocarboxylic acid derivatives of triarylmethyl radicals (TAMs) were developed. Reaction of methyl thioglycolate with tris(2,3,5,6-tetrathiaaryl)methyl cation smoothly afforded the monosubstituted TAM derivative, which was hydrolyzed to a monocarboxylic acid, with the TAM moiety attached to thioglycolic acid via the sulfur atom. Alternatively, the diamagnetic tricarboxylic acid precursor of Finland trityl was transformed to a trimethyl ester and partially hydrolyzed under controlled conditions. The diester product was isolated and the remaining fractions were converted back to the trimethyl ester for production of more diester. The first representatives of TAM biradicals with different TAM cores and interspin distances were obtained by reaction of these new TAM monocaboxylic acids with N,N'-dimethylethylenediamine.

  16. Evaluation of Online Video Usage and Learning Satisfaction: An Extension of the Technology Acceptance Model

    Science.gov (United States)

    Nagy, Judit T.

    2018-01-01

    The aim of the study was to examine the determining factors of students' video usage and their learning satisfaction relating to the supplementary application of educational videos, accessible in a Moodle environment in a Business Mathematics Course. The research model is based on the extension of "Technology Acceptance Model" (TAM), in…

  17. An Exploration of Student Internet Use in India: The Technology Acceptance Model and the Theory of Planned Behaviour

    Science.gov (United States)

    Fusilier, Marcelline; Durlabhji, Subhash

    2005-01-01

    Purpose: The purpose of this paper is to explore behavioral processes involved in internet technology acceptance and use with a sample in India, a developing country that can potentially benefit from greater participation in the web economy. Design/methodology/approach - User experience was incorporated into the technology acceptance model (TAM)…

  18. An extension of the technology acceptance model for business intelligence systems: project management maturity perspective

    Directory of Open Access Journals (Sweden)

    Mirjana Pejić Bach

    2017-01-01

    Full Text Available Business intelligence systems (BISs refer to wide range of technologies and applications useful for retrieving and analyzing the large amount of information with the goal to generate knowledge useful for making effective business decision. In order to investigate adoption of BISs in companies, we propose a model based on the technology acceptance model (TAM that is expanded by variables representing the concept of a project management maturity (PMM. The survey on the sample of USA companies has been conducted with the chief information officer (CIO as the main informant. Structural equations model has been developed in order to test the research model. Results indicate that TAM expanded with the notion of PMM is useful in increasing understanding of BISs adoption in companies.

  19. Examining the Factors Affecting PDA Acceptance among Physicians: An Extended Technology Acceptance Model.

    Science.gov (United States)

    Basak, Ecem; Gumussoy, Cigdem Altin; Calisir, Fethi

    2015-01-01

    This study aims at identifying the factors affecting the intention to use personal digital assistant (PDA) technology among physicians in Turkey using an extended Technology Acceptance Model (TAM). A structural equation-modeling approach was used to identify the variables that significantly affect the intention to use PDA technology. The data were collected from 339 physicians in Turkey. Results indicated that 71% of the physicians' intention to use PDA technology is explained by perceived usefulness and perceived ease of use. On comparing both, the perceived ease of use has the strongest effect, whereas the effect of perceived enjoyment on behavioral intention to use is found to be insignificant. This study concludes with the recommendations for managers and possible future research.

  20. Validating the Satisfaction and Continuance Intention of E-Learning Systems: Combining TAM and IS Success Models

    Science.gov (United States)

    Lin, Tung-Cheng; Chen, Ching-Jen

    2012-01-01

    Many e-learning studies have evaluated learning attitudes and behaviors, based on TAM. However, a successful e-learning system (ELS) should take both system and information quality into account by applying ISM developed by Delone and McLean. In addition, the acceptance for information system depends on the perceived usefulness and ease of use…

  1. Blog acceptance model: An empirical study on exploring users’ acceptance and continual usage of blogs

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Yuxiang; ZHU; Qinghua

    2009-01-01

    Blogs have permeated into our daily lives at a fast speed,and various kinds of blog spaces have attracted our attention.However,little effort has been made on studying the users’motivation to participate in blog activities.This paper aims to construct a theoretical model about the blog adoption based on technology acceptance model(TAM theory),social capital theory and social exchange theory,and put forward 18 related hypotheses.Then the survey method is adopted to analyze the data from 208 questionnaires using the SPSS and LISREL tools,and to examine the theoretical model and hypotheses.Finally,the paper makes a discussion from five aspects due to the results of data analysis,including individual driving factors,group driving factors,community driving factors,technology acceptance factors and moderating variables.The results show that curiosity/enjoyment,user’s experience,social interaction and social identification will greatly affect users’motivation to accept a blog;meanwhile,perceived ease of use,exchange cost and trust will partially influence users’intention to participate in blog activities.The results also suggest that age and education degrees have significant moderating effects on users’acceptance and updating of blogs.

  2. Technology acceptance model and the paths to online customer loyalty in an emerging market

    Directory of Open Access Journals (Sweden)

    Nguyen Thi Tuyet Mai

    2013-12-01

    Full Text Available The technology acceptance model (TAM has been well-known for decades. However, the global adoption of the Internet creates new interests in utilizing TAM in e-commerce and the post-consumption intention, especially in emerging markets. Data was collected from 758 online customers via a web-based survey in Vietnam. Particular contribution of the results is that perceived usefulness, perceived ease of use, fairness, trust and the quality of the customer interface have direct or indirect impacts on customer satisfaction and customer loyalty. Moreover, in emerging markets, trust was outlined as the strongest factor contributing to customer satisfaction and leading to customer loyalty.

  3. Physiology and transcriptomics of water-deficit stress responses in wheat cultivars TAM 111 and TAM 112.

    Science.gov (United States)

    Reddy, Srirama Krishna; Liu, Shuyu; Rudd, Jackie C; Xue, Qingwu; Payton, Paxton; Finlayson, Scott A; Mahan, James; Akhunova, Alina; Holalu, Srinidhi V; Lu, Nanyan

    2014-09-01

    Hard red winter wheat crops on the U.S. Southern Great Plains often experience moderate to severe drought stress, especially during the grain filling stage, resulting in significant yield losses. Cultivars TAM 111 and TAM 112 are widely cultivated in the region, share parentage and showed superior but distinct adaption mechanisms under water-deficit (WD) conditions. Nevertheless, the physiological and molecular basis of their adaptation remains unknown. A greenhouse study was conducted to understand the differences in the physiological and transcriptomic responses of TAM 111 and TAM 112 to WD stress. Whole-plant data indicated that TAM 112 used more water, produced more biomass and grain yield under WD compared to TAM 111. Leaf-level data at the grain filling stage indicated that TAM 112 had elevated abscisic acid (ABA) content and reduced stomatal conductance and photosynthesis as compared to TAM 111. Sustained WD during the grain filling stage also resulted in greater flag leaf transcriptome changes in TAM 112 than TAM 111. Transcripts associated with photosynthesis, carbohydrate metabolism, phytohormone metabolism, and other dehydration responses were uniquely regulated between cultivars. These results suggested a differential role for ABA in regulating physiological and transcriptomic changes associated with WD stress and potential involvement in the superior adaptation and yield of TAM 112. Copyright © 2014 Elsevier GmbH. All rights reserved.

  4. Modelling Facebook Usage among University Students in Thailand: The Role of Emotional Attachment in an Extended Technology Acceptance Model

    Science.gov (United States)

    Teo, Timothy

    2016-01-01

    The aim of this study is to examine the factors that influenced the use of Facebook among university students. Using an extended technology acceptance model (TAM) with emotional attachment (EA) as an external variable, a sample of 498 students from a public-funded Thailand university were surveyed on their responses to five variables hypothesized…

  5. Learning Computerese: The Role of Second Language Learning Aptitude in Technology Acceptance

    Science.gov (United States)

    Warner, Janis A.; Koufteros, Xenophon; Verghese, Anto

    2014-01-01

    This article introduces a new construct coined as Computer User Learning Aptitude (CULA). To establish construct validity, CULA is embedded in a nomological network that extends the technology acceptance model (TAM). Specifically, CULA is posited to affect perceived usefulness and perceived ease of use, the two underlying TAM constructs.…

  6. Assessing user acceptance towards automated and conventional sink use for hand decontamination using the technology acceptance model.

    Science.gov (United States)

    Dawson, Carolyn H; Mackrill, Jamie B; Cain, Rebecca

    2017-12-01

    Hand hygiene (HH) prevents harmful contaminants spreading in settings including domestic, health care and food handling. Strategies to improve HH range from behavioural techniques through to automated sinks that ensure hand surface cleaning. This study aimed to assess user experience and acceptance towards a new automated sink, compared to a normal sink. An adapted version of the technology acceptance model (TAM) assessed each mode of handwashing. A within-subjects design enabled N = 46 participants to evaluate both sinks. Perceived Ease of Use and Satisfaction of Use were significantly lower for the automated sink, compared to the conventional sink (p technology. We provide recommendations for future HH technology development to contribute a positive user experience, relevant to technology developers, ergonomists and those involved in HH across all sectors. Practitioner Summary: The need to facilitate timely, effective hand hygiene to prevent illness has led to a rise in automated handwashing systems across different contexts. User acceptance is a key factor in system uptake. This paper applies the technology acceptance model as a means to explore and optimise the design of such systems.

  7. Factors Affecting Acceptance of Hospital Information Systems Based on Extended Technology Acceptance Model: A Case Study in Three Paraclinical Departments.

    Science.gov (United States)

    Nadri, Hamed; Rahimi, Bahlol; Lotfnezhad Afshar, Hadi; Samadbeik, Mahnaz; Garavand, Ali

    2018-04-01

     Regardless of the acceptance of users, information and communication systems can be considered as a health intervention designed to improve the care delivered to patients. This study aimed to determine the adoption and use of the extended Technology Acceptance Model (TAM2) by the users of hospital information system (HIS) in paraclinical departments including laboratory, radiology, and nutrition and to investigate the key factors of adoption and use of these systems.  A standard questionnaire was used to collect the data from nearly 253 users of these systems in paraclinical departments of eight university hospitals in two different cities of Iran. A total of 202 questionnaires including valid responses were used in this study (105 in Urmia and 97 in Khorramabad). The data were processed using LISREL and SPSS software and statistical analysis technique was based on the structural equation modeling (SEM).  It was found that the original TAM constructs had a significant impact on the staffs' behavioral intention to adopt HIS in paraclinical departments. The results of this study indicated that cognitive instrumental processes (job relevance, output quality, result demonstrability, and perceived ease of use), except for result demonstrability, were significant predictors of intention to use, whereas the result revealed no significant relationship between social influence processes (subjective norm, voluntariness, and image) and the users' behavioral intention to use the system.  The results confirmed that several factors in the TAM2 that were important in previous studies were not significant in paraclinical departments and in government-owned hospitals. The users' behavior factors are essential for successful usage of the system and should be considered. It provides valuable information for hospital system providers and policy makers in understanding the adoption challenges as well as practical guidance for the successful implementation of information

  8. Using a modified technology acceptance model to evaluate healthcare professionals' adoption of a new telemonitoring system.

    Science.gov (United States)

    Gagnon, Marie Pierre; Orruño, Estibalitz; Asua, José; Abdeljelil, Anis Ben; Emparanza, José

    2012-01-01

    To examine the factors that could influence the decision of healthcare professionals to use a telemonitoring system. A questionnaire, based on the Technology Acceptance Model (TAM), was developed. A panel of experts in technology assessment evaluated the face and content validity of the instrument. Two hundred and thirty-four questionnaires were distributed among nurses and doctors of the cardiology, pulmonology, and internal medicine departments of a tertiary hospital. Cronbach alpha was calculated to measure the internal consistency of the questionnaire items. Construct validity was evaluated using interitem correlation analysis. Logistic regression analysis was performed to test the theoretical model. Adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were computed. A response rate of 39.7% was achieved. With the exception of one theoretical construct (Habit) that corresponds to behaviors that become automatized, Cronbach alpha values were acceptably high for the remaining constructs. Theoretical variables were well correlated with each other and with the dependent variable. The original TAM was good at predicting telemonitoring usage intention, Perceived Usefulness being the only significant predictor (OR: 5.28, 95% CI: 2.12-13.11). The model was still significant and more powerful when the other theoretical variables were added. However, the only significant predictor in the modified model was Facilitators (OR: 4.96, 95% CI: 1.59-15.55). The TAM is a good predictive model of healthcare professionals' intention to use telemonitoring. However, the perception of facilitators is the most important variable to consider for increasing doctors' and nurses' intention to use the new technology.

  9. TAM receptors regulate multiple features of microglial physiology.

    Science.gov (United States)

    Fourgeaud, Lawrence; Través, Paqui G; Tufail, Yusuf; Leal-Bailey, Humberto; Lew, Erin D; Burrola, Patrick G; Callaway, Perri; Zagórska, Anna; Rothlin, Carla V; Nimmerjahn, Axel; Lemke, Greg

    2016-04-14

    Microglia are damage sensors for the central nervous system (CNS), and the phagocytes responsible for routine non-inflammatory clearance of dead brain cells. Here we show that the TAM receptor tyrosine kinases Mer and Axl regulate these microglial functions. We find that adult mice deficient in microglial Mer and Axl exhibit a marked accumulation of apoptotic cells specifically in neurogenic regions of the CNS, and that microglial phagocytosis of the apoptotic cells generated during adult neurogenesis is normally driven by both TAM receptor ligands Gas6 and protein S. Using live two-photon imaging, we demonstrate that the microglial response to brain damage is also TAM-regulated, as TAM-deficient microglia display reduced process motility and delayed convergence to sites of injury. Finally, we show that microglial expression of Axl is prominently upregulated in the inflammatory environment that develops in a mouse model of Parkinson's disease. Together, these results establish TAM receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in CNS disease.

  10. Faculty Perceptions about Teaching Online: Exploring the Literature Using the Technology Acceptance Model as an Organizing Framework

    Science.gov (United States)

    Wingo, Nancy Pope; Ivankova, Nataliya V.; Moss, Jacqueline A.

    2017-01-01

    Academic leaders can better implement institutional strategic plans to promote online programs if they understand faculty perceptions about teaching online. An extended version of a model for technology acceptance, or TAM2 (Venkatesh & Davis, 2000), provided a framework for surveying and organizing the research literature about factors that…

  11. Targeting the TAM Receptors in Leukemia.

    Science.gov (United States)

    Huey, Madeline G; Minson, Katherine A; Earp, H Shelton; DeRyckere, Deborah; Graham, Douglas K

    2016-11-08

    Targeted inhibition of members of the TAM (TYRO-3, AXL, MERTK) family of receptor tyrosine kinases has recently been investigated as a novel strategy for treatment of hematologic malignancies. The physiologic functions of the TAM receptors in innate immune control, natural killer (NK) cell differentiation, efferocytosis, clearance of apoptotic debris, and hemostasis have previously been described and more recent data implicate TAM kinases as important regulators of erythropoiesis and megakaryopoiesis. The TAM receptors are aberrantly or ectopically expressed in many hematologic malignancies including acute myeloid leukemia, B- and T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma. TAM receptors contribute to leukemic phenotypes through activation of pro-survival signaling pathways and interplay with other oncogenic proteins such as FLT3, LYN, and FGFR3. The TAM receptors also contribute to resistance to both cytotoxic chemotherapeutics and targeted agents, making them attractive therapeutic targets. A number of translational strategies for TAM inhibition are in development, including small molecule inhibitors, ligand traps, and monoclonal antibodies. Emerging areas of research include modulation of TAM receptors to enhance anti-tumor immunity, potential roles for TYRO-3 in leukemogenesis, and the function of the bone marrow microenvironment in mediating resistance to TAM inhibition.

  12. Targeting the TAM Receptors in Leukemia

    Directory of Open Access Journals (Sweden)

    Madeline G. Huey

    2016-11-01

    Full Text Available Targeted inhibition of members of the TAM (TYRO-3, AXL, MERTK family of receptor tyrosine kinases has recently been investigated as a novel strategy for treatment of hematologic malignancies. The physiologic functions of the TAM receptors in innate immune control, natural killer (NK cell differentiation, efferocytosis, clearance of apoptotic debris, and hemostasis have previously been described and more recent data implicate TAM kinases as important regulators of erythropoiesis and megakaryopoiesis. The TAM receptors are aberrantly or ectopically expressed in many hematologic malignancies including acute myeloid leukemia, B- and T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma. TAM receptors contribute to leukemic phenotypes through activation of pro-survival signaling pathways and interplay with other oncogenic proteins such as FLT3, LYN, and FGFR3. The TAM receptors also contribute to resistance to both cytotoxic chemotherapeutics and targeted agents, making them attractive therapeutic targets. A number of translational strategies for TAM inhibition are in development, including small molecule inhibitors, ligand traps, and monoclonal antibodies. Emerging areas of research include modulation of TAM receptors to enhance anti-tumor immunity, potential roles for TYRO-3 in leukemogenesis, and the function of the bone marrow microenvironment in mediating resistance to TAM inhibition.

  13. The acceptance of microblogging in the learning process: The µBAM model

    Directory of Open Access Journals (Sweden)

    Francisco Rejón-Guardia

    2013-03-01

    Full Text Available Microblogging social networks (µBSNs provide the opportunity to communicate worldwide making use of a small number of characters; an apparent limitation that forces users to share only essential information when linking to the world with which they interact. These platforms can serve to motivate students by narrowing the physical and psychological distances separating teachers and students, thus increasing their confidence and engagement in the learning process. The main thrust of this paper is based on the notion that µBSN opens a window on informal knowledge, self-directed learning and the creation of knowledge-based networks for use in the classroom setting. To examine this issue in greater depth, an experiment was carried out using a µBSN before, during and after face-to-face class sessions. In this study we used the Technology Acceptance Model (TAM, incorporating some of the constructs commonly found in the scientific literature. These constructs refer to the effect of subjective norms and social images on the use of web-based social networks. The analysis gave rise to a robust and parsimonious model of social network usage behavior that confirmed the proposed research hypotheses. The findings demonstrated that he extended TAM model is suitable for explaining the acceptance of web-based teaching tools as well as the validity of microblogging networks in combination with traditional classes.

  14. A Quantitative Study of Faculty Perceptions and Attitudes on Asynchronous Virtual Teamwork Using the Technology Acceptance Model

    Science.gov (United States)

    Wolusky, G. Anthony

    2016-01-01

    This quantitative study used a web-based questionnaire to assess the attitudes and perceptions of online and hybrid faculty towards student-centered asynchronous virtual teamwork (AVT) using the technology acceptance model (TAM) of Davis (1989). AVT is online student participation in a team approach to problem-solving culminating in a written…

  15. A Study of Using Technology Acceptance Model and Its Effect on Improving Road Pavement Smoothness in Taiwan

    Science.gov (United States)

    Huang, Long-Sheng; Huang, Chung-Fah

    2017-01-01

    Using the technology acceptance model (TAM) as its theoretical foundation, this study intends to explore the use of Travelling Beam devices in road engineerings in Taiwan and offer suggestions based on its findings to encourage industry willingness for device deployment resulting in improving road pavement smoothness in Taiwan. The study subjects…

  16. Technology Acceptance of Electronic Medical Records by Nurses

    Science.gov (United States)

    Stocker, Gary

    2010-01-01

    The purpose of this study was to evaluate the Technology Acceptance Model's (TAM) relevance of the intention of nurses to use electronic medical records in acute health care settings. The basic technology acceptance research of Davis (1989) was applied to the specific technology tool of electronic medical records (EMR) in a specific setting…

  17. Technology Acceptance among Pre-Service Teachers: Does Gender Matter?

    Science.gov (United States)

    Teo, Timothy; Fan, Xitao; Du, Jianxia

    2015-01-01

    This study examined possible gender differences in pre-service teachers' perceived acceptance of technology in their professional work under the framework of the technology acceptance model (TAM). Based on a sample of pre-service teachers, a series of progressively more stringent measurement invariance tests (configural, metric, and scalar…

  18. Information technology acceptance in health information management.

    Science.gov (United States)

    Abdekhoda, M; Ahmadi, M; Dehnad, A; Hosseini, A F

    2014-01-01

    User acceptance of information technology has been a significant area of research for more than two decades in the field of information technology. This study assessed the acceptance of information technology in the context of Health Information Management (HIM) by utilizing Technology Acceptance Model (TAM) which was modified and applied to assess user acceptance of health information technology as well as viability of TAM as a research construct in the context of HIM. This was a descriptive- analytical study in which a sample of 187 personnel from a population of 363 personnel, working in medical records departments of hospitals affiliated to Tehran University of Medical Sciences, was selected. Users' perception of applying information technology was studied by a researcher-developed questionnaire. Collected data were analyzed by SPSS software (version16) using descriptive statistics and regression analysis. The results suggest that TAM is a useful construct to assess user acceptance of information technology in the context of HIM. The findings also evidenced the perceived ease of use (PEOU) and perceived usefulness (PE) were positively associated with favorable users' attitudes towards HIM. PU was relatively more associated (r= 0.22, p = 0.05) than PEOU (r = 0.014, p = 0.05) with favorable user attitudes towards HIM. Users' perception of usefulness and ease of use are important determinants providing the incentive for users to accept information technologies when the application of a successful HIM system is attempted. The findings of the present study suggest that user acceptance is a key element and should subsequently be the major concern of health organizations and health policy makers.

  19. Students’ Perceptions About Learning Environment of a Distance Course Based on Technology Acceptance Model: A Descriptive Study

    Directory of Open Access Journals (Sweden)

    Erman UZUN

    2013-03-01

    Full Text Available Technology Acceptance Model (TAM is a measure to assess the underlying reasons about the use of a technology. In this study an extended version of TAM were used. This extended version composed of three factors. These are “perceived motivation towards learning environment”, “perceived usefulness” and “perceived ease of use”. In this study, the learning environment of a distance course was investigated to see students’ perceptions. This distance course was delivered from one university to the other university via video-conferencing with ITL Learning Gateway content management system during the whole semester. The participants were the 32 first year vocational higher education institution students. The descriptive findings revealed that each factor of TAM perceived by students as having moderate advantages. It is believed that the underlying reason of this situation was based on the students’ low computer competency and e-learning experiences.

  20. Examining the Intention to Use Technology among Pre-Service Teachers: An Integration of the Technology Acceptance Model and Theory of Planned Behavior

    Science.gov (United States)

    Teo, Timothy

    2012-01-01

    This study examined pre-service teachers' self-reported intention to use technology. One hundred fifty-seven participants completed a survey questionnaire measuring their responses to six constructs from a research model that integrated the Technology Acceptance Model (TAM) and Theory of Planned Behavior (TPB). Structural equation modeling was…

  1. TAM receptor signaling in development.

    Science.gov (United States)

    Burstyn-Cohen, Tal

    2017-01-01

    TYRO3, AXL and MERTK comprise the TAM family of receptor protein tyrosine kinases. Activated by their ligands, protein S (PROS1) and growth-arrest-specific 6 (GAS6), they mediate numerous cellular functions throughout development and adulthood. Expressed by a myriad of cell types and tissues, they have been implicated in homeostatic regulation of the immune, nervous, vascular, bone and reproductive systems. The loss-of-function of TAM signaling in adult tissues culminates in the destruction of tissue homeostasis and diseased states, while TAM gain-of-function in various tumors promotes cancer phenotypes. Combinatorial ligand-receptor interactions may elicit different molecular and cellular responses. Many of the TAM regulatory functions are essentially developmental, taking place both during embryogenesis and postnatally. This review highlights current knowledge on the role of TAM receptors and their ligands during these developmental processes in the immune, nervous, vascular and reproductive systems.

  2. Factors of Online Learning Adoption: A Comparative Juxtaposition of the Theory of Planned Behaviour and the Technology Acceptance Model

    Science.gov (United States)

    Ndubisi, Nelson

    2006-01-01

    Organisational investments in information technologies have increased significantly in the past few decades. All around the globe and in Malaysia particularly, a number of educational institutions are experimenting with e-learning. Adopting the theory of planned behaviour (TPB) and the technology acceptance model (TAM) this article tries to…

  3. E-learning acceptance based on technology acceptance model (TAM)

    African Journals Online (AJOL)

    Data were collected with 95 undergraduate students at Tunku Abdul Rahman University College (TARUC), Johor. Structural Equation Modeling (SEM) was used to analyze the data. Results shown that computer self-efficacyhas significantly effects ease of use, while perceived ease of use significantly affectsintention to use ...

  4. Assessing the Acceptance of a Blended Learning University Course

    Science.gov (United States)

    Tselios, Nikolaos; Daskalakis, Stelios; Papadopoulou, Maria

    2011-01-01

    Usefulness and ease of use proved to be key determinants of the acceptance and usage of e-learning. On the contrary, little is known about students' perceptions in a blended learning setting. In this paper, the Technology Acceptance Model (TAM) was utilised, in order to investigate Greek university students' attitudes toward blended learning. The…

  5. Thioredoxin 80-Activated-Monocytes (TAMs) Inhibit the Replication of Intracellular Pathogens

    DEFF Research Database (Denmark)

    Cortes-Bratti, Ximena; Brasseres, Eugenie; Herrera-Rodriquez, Fabiola

    2011-01-01

    Background: Thioredoxin 80 (Trx80) is an 80 amino acid natural cleavage product of Trx, produced primarily by monocytes. Trx80 induces differentiation of human monocytes into a novel cell type, named Trx80-activated-monocytes (TAMs). Principal Findings: In this investigation we present evidence...... for a role of TAMs in the control of intracellular bacterial infections. As model pathogens we have chosen Listeria monocytogenes and Brucella abortus which replicate in the cytosol and the endoplasmic reticulum respectively. Our data indicate that TAMs efficiently inhibit intracellular growth of both L...... in TAMs compared to that observed in control cells 24 h post-infection, indicating that TAMs kill bacteria by preventing their escape from the endosomal compartments, which progress into a highly degradative phagolysosome. Significance: Our results show that Trx80 potentiates the bactericidal activities...

  6. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity.

    Science.gov (United States)

    Kimani, Stanley G; Kumar, Sushil; Bansal, Nitu; Singh, Kamalendra; Kholodovych, Vladyslav; Comollo, Thomas; Peng, Youyi; Kotenko, Sergei V; Sarafianos, Stefan G; Bertino, Joseph R; Welsh, William J; Birge, Raymond B

    2017-03-08

    TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous type I receptor tyrosine kinases that are implicated in several human malignancies. Overexpression of TAMs and their major ligand Growth arrest-specific factor 6 (Gas6) is associated with more aggressive staging of cancers, poorer predicted patient survival, acquired drug resistance and metastasis. Here we describe small molecule inhibitors (RU-301 and RU-302) that target the extracellular domain of Axl at the interface of the Ig-1 ectodomain of Axl and the Lg-1 of Gas6. These inhibitors effectively block Gas6-inducible Axl receptor activation with low micromolar IC 50s in cell-based reporter assays, inhibit Gas6-inducible motility in Axl-expressing cell lines, and suppress H1299 lung cancer tumor growth in a mouse xenograft NOD-SCIDγ model. Furthermore, using homology models and biochemical verifications, we show that RU301 and 302 also inhibit Gas6 inducible activation of Mertk and Tyro3 suggesting they can act as pan-TAM inhibitors that block the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. Together, these observations establish that small molecules that bind to the interface between TAM Ig1 domain and Gas6 Lg1 domain can inhibit TAM activation, and support the further development of small molecule Gas6-TAM interaction inhibitors as a novel class of cancer therapeutics.

  7. An Extended Technology Acceptance Model for Mobile Social Gaming Service Popularity Analysis

    Directory of Open Access Journals (Sweden)

    Hui Chen

    2017-01-01

    Full Text Available The games industry has been growing prosperously with the development of information technology. Recently, with further advances in social networks and mobile services, playing mobile social gaming has gradually changed our daily life in terms of social connection and leisure time spending. What are the determinant factors which affect users intention to play such games? Therefore in this research we present an empirical study on WeChat, China’s most popular mobile social network, and apply a technology acceptance model (TAM to study the reasons beneath the popularity of games in mobile social networks. Furthermore, factors from social and mobile perspective are incorporated into the conventional TAM and their influence and relationships are studied. Experimental study on accumulated online survey data reveals several interesting findings and it is believed that this research offers the researchers in the community further insight in analysing the current popularity and future potential of mobile social games.

  8. Acceptance of Swedish e-health services

    Directory of Open Access Journals (Sweden)

    Mary-Louise Jung

    2010-11-01

    Full Text Available Mary-Louise Jung1, Karla Loria11Division of Industrial Marketing, e-Commerce and Logistics, Lulea University of Technology, SwedenObjective: To investigate older people’s acceptance of e-health services, in order to identify determinants of, and barriers to, their intention to use e-health.Method: Based on one of the best-established models of technology acceptance, Technology Acceptance Model (TAM, in-depth exploratory interviews with twelve individuals over 45 years of age and of varying backgrounds are conducted.Results: This investigation could find support for the importance of usefulness and perceived ease of use of the e-health service offered as the main determinants of people’s intention to use the service. Additional factors critical to the acceptance of e-health are identified, such as the importance of the compatibility of the services with citizens’ needs and trust in the service provider. Most interviewees expressed positive attitudes towards using e-health and find these services useful, convenient, and easy to use.Conclusion: E-health services are perceived as a good complement to traditional health care service delivery, even among older people. These people, however, need to become aware of the e-health alternatives that are offered to them and the benefits they provide.Keywords: health services, elderly, technology, Internet, TAM, patient acceptance, health-seeking behavior

  9. Technology Acceptance and User Experience: A Review of the Experiential Component in HCI

    DEFF Research Database (Denmark)

    Hornbæk, Kasper; Hertzum, Morten

    2017-01-01

    Understanding the mechanisms that shape the adoption and use of information technology is central to human-computer interaction. Two accounts are particularly vocal about these mechanisms, namely the technology acceptance model (TAM) and work on user experience (UX) models. In this study we review...... 37 papers in the overlap between TAM and UX models to explore the experiential component of human-computer interactions. The models provide rich insights about what constructs influence the experiential component of human-computer interactions and about how these constructs are related. For example...

  10. Integrating health belief model and technology acceptance model: an investigation of health-related internet use.

    Science.gov (United States)

    Ahadzadeh, Ashraf Sadat; Pahlevan Sharif, Saeed; Ong, Fon Sim; Khong, Kok Wei

    2015-02-19

    Today, people use the Internet to satisfy health-related information and communication needs. In Malaysia, Internet use for health management has become increasingly significant due to the increase in the incidence of chronic diseases, in particular among urban women and their desire to stay healthy. Past studies adopted the Technology Acceptance Model (TAM) and Health Belief Model (HBM) independently to explain Internet use for health-related purposes. Although both the TAM and HBM have their own merits, independently they lack the ability to explain the cognition and the related mechanism in which individuals use the Internet for health purposes. This study aimed to examine the influence of perceived health risk and health consciousness on health-related Internet use based on the HBM. Drawing on the TAM, it also tested the mediating effects of perceived usefulness of the Internet for health information and attitude toward Internet use for health purposes for the relationship between health-related factors, namely perceived health risk and health consciousness on health-related Internet use. Data obtained for the current study were collected using purposive sampling; the sample consisted of women in Malaysia who had Internet access. The partial least squares structural equation modeling method was used to test the research hypotheses developed. Perceived health risk (β=.135, t1999=2.676) and health consciousness (β=.447, t1999=9.168) had a positive influence on health-related Internet use. Moreover, perceived usefulness of the Internet and attitude toward Internet use for health-related purposes partially mediated the influence of health consciousness on health-related Internet use (β=.025, t1999=3.234), whereas the effect of perceived health risk on health-related Internet use was fully mediated by perceived usefulness of the Internet and attitude (β=.029, t1999=3.609). These results suggest the central role of perceived usefulness of the Internet and

  11. The Role of Peer Influence and Perceived Quality of Teaching in Faculty Acceptance of Web-Based Learning Management Systems

    Science.gov (United States)

    Salajan, Florin D.; Welch, Anita G.; Ray, Chris M.; Peterson, Claudette

    2015-01-01

    This study's primary investigation is the impact of "peer influence" and "perceived quality of teaching" on faculty members' usage of web-based learning management systems within the Technology Acceptance Model (TAM) framework. These factors are entered into an extended TAM as external variables impacting on the core constructs…

  12. Pengaruh Gadget Terhadap Prestasi Siswa SMK Yayasan Islam Tasikmalaya Dengan Metode TAM

    Directory of Open Access Journals (Sweden)

    Arif Rifan Hidayat

    2017-09-01

    Full Text Available Abstrak Gadget merupakan suatu barang dengan berbagai aplikasi yang dapat menyajikan berbagai media berita, jejaring sosial, hobi, bahkan hiburan. Prestasi belajar adalah hasil atau taraf kemampuan yang telah dicapai siswa setelah mengikuti proses belajar mengajar dalam waktu tertentu, baik berupa perubahan tingkah laku, keterampilan, dan pengetahuan. Kemudian akan diukur dan dinilai dalam angka atau pernyataan. Tujuan penelitian ini untuk mengetahui pengaruh gadget terhadap prestasi siswa di SMK Yayasan Islam Tasikmalaya. Metode penelitian yang digunakan yaitu dengan metode Technology Acceptance Model (TAM dengan 3 konstruk, yaitu persepsi pengguna terhadap manfaat (perceived usefulness, persepsi pengguna terhadap penggunaan (perceived ease of use dan persepsi sikap terhadap penggunaan (attitude toward using. Populasi penelitian ini adalah Siswa kelas X dan XI  SMK Yayasan Islam Tasikmalaya sebanyak 100 orang. Instrumen yang digunakan dalam penelitian ini adalah kuesioner. Berdasarkan hasil penelitian dan pengujian hipotesis didapatkan hasil pengujian fhitung adalah 1,157. Persamaan hipotesis menyatakan bahwa nilai signifikasinya sebesar 0,319 > α 0,05 lebih besar dari ftabel. Dengan demikian dikatakan bahwa H0 diterima dan Ha ditolak, sehingga hipotesis berbunyi terdapat pengaruh yang signifikan antara variabel perceived usefulness (X1, dan perceived ease of use (X2 terhadap Attitude Toward Using (Y secara simultan. Pengaruh Perceived Usefulness (X1 dan Perceived Ease Of Use (X2 secara bersama-sama terhadap Attitude Toward Using (Y adalah sebesar 2,3%, dan sisanya sebesar 97,7% merupakan pengaruh yang diberikan oleh variabel lain diluar model atau penelitian ini.   Kata Kunci: TAM , Gadget, Prestasi. Abstract Gadgets are an item with various applications that can present various news media, social networking, hobbies, even entertainment. Learning achievement is the result or level of ability that has been achieved by students after

  13. Development of a tripolar model of technology acceptance: Hospital-based physicians' perspective on EHR.

    Science.gov (United States)

    Beglaryan, Mher; Petrosyan, Varduhi; Bunker, Edward

    2017-06-01

    In health care, information technologies (IT) hold a promise to harness an ever-increasing flow of health related information and bring significant benefits including improved quality of care, efficiency, and cost containment. One of the main tools for collecting and utilizing health data is the Electronic Health Record (EHR). EHRs implementation can face numerous barriers to acceptance including attitudes and perceptions of potential users, required effort attributed to their implementation and usage, and resistance to change. Various theories explicate different aspects of technology deployment, implementation, and acceptance. One of the common theories is the Technology Acceptance Model (TAM), which helps to study the implementation of different healthcare IT applications. The objectives of this study are: to understand the barriers of EHR implementation from the perspective of physicians; to identify major determinants of physicians' acceptance of technology; and develop a model that explains better how EHRs (and technologies in general) are accepted by physicians. The proposed model derives from a cross-sectional survey of physicians selected through multi-stage cluster sampling from the hospitals of Yerevan, Armenia. The study team designed the survey instrument based on a literature review on barriers of EHR implementation. The analysis employed exploratory structural equation modeling (ESEM) with a robust weighted least squares (WLSMV) estimator for categorical indicators. The analysis progressed in two steps: appraisal of the measurement model and testing of the structural model. The derived model identifies the following factors as direct determinants of behavioral intention to use a novel technology: projected collective usefulness; personal innovativeness; patient influence; and resistance to change. Other factors (e.g., organizational change, professional relationships, administrative monitoring, organizational support and computer anxiety) exert their

  14. Using a modified technology acceptance model in hospitals.

    Science.gov (United States)

    Aggelidis, Vassilios P; Chatzoglou, Prodromos D

    2009-02-01

    The use of information technology in the health care sector and especially in hospitals offers great potential for improving the quality of services provided and the efficiency and effectiveness of the personnel, but also for reducing the organizational expenses. However, the main question that arises according to the literature is whether hospital personnel are willing to use state of the art information technology while performing their tasks. This study attempts to address this issue by developing and testing a modified technology acceptance model taking into consideration other relevant models found in the literature. The original TAM has been extended to include some exogenous variables in order to examine HIS acceptance by Greek hospital personnel. Correlation, explanatory and confirmation factor analysis was performed to test the reliability and validity of the measurement model. The structural equation modeling technique has also been used to evaluate the causal model. The results indicate that perceived usefulness, ease of use, social influence, attitude, facilitating conditions and self-efficacy significantly affect hospital personnel behavioral intention. Training has a strong indirect impact on behavioral intention through the mediators of facilitating condition and ease of use. Furthermore, the existence of significant positive effects between self-efficacy and social influence, perceived usefulness and anxiety, and facilitating conditions and social influence is also supported. The proposed model can explain 87% of the variance of behavioral intention indicating that the core constructs of the technology acceptance models have a strong and statistically significant influence on hospital personnel usage intention.

  15. TAM Receptor Signaling in Immune Homeostasis

    Science.gov (United States)

    Rothlin, Carla V.; Carrera-Silva, Eugenio A.; Bosurgi, Lidia; Ghosh, Sourav

    2015-01-01

    The TAM receptor tyrosine kinases (RTKs)—TYRO3, AXL, and MERTK—together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease. PMID:25594431

  16. Impact of Collaborative Work on Technology Acceptance: A Case Study from Virtual Computing

    Science.gov (United States)

    Konak, Abdullah; Kulturel-Konak, Sadan; Nasereddin, Mahdi; Bartolacci, Michael R.

    2017-01-01

    Aim/Purpose: This paper utilizes the Technology Acceptance Model (TAM) to examine the extent to which acceptance of Remote Virtual Computer Laboratories (RVCLs) is affected by students' technological backgrounds and the role of collaborative work. Background: RVCLs are widely used in information technology and cyber security education to provide…

  17. Using Innovation Diffusion Theory and the Technolgy Acceptance Model to Evaluate the Security of Wireless Mobile Devices at a Post Secondary Institution

    Science.gov (United States)

    Feliciano-Torres, Hector L.

    2017-01-01

    The purpose of this quantitative, descriptive non experimental study was to investigate the use of wireless mobile network devices at a post-secondary institution using the innovation diffusion theory (IDT) and technology acceptance model (TAM) as background theories. The researcher intended to explore how students and personnel of the institution…

  18. An extended technology acceptance model for detecting influencing factors: An empirical investigation

    Directory of Open Access Journals (Sweden)

    Mohamd Hakkak

    2013-11-01

    Full Text Available The rapid diffusion of the Internet has radically changed the delivery channels applied by the financial services industry. The aim of this study is to identify the influencing factors that encourage customers to adopt online banking in Khorramabad. The research constructs are developed based on the technology acceptance model (TAM and incorporates some extra important control variables. The model is empirically verified to study the factors influencing the online banking adoption behavior of 210 customers of Tejarat Banks in Khorramabad. The findings of the study suggest that the quality of the internet connection, the awareness of online banking and its benefits, the social influence and computer self-efficacy have significant impacts on the perceived usefulness (PU and perceived ease of use (PEOU of online banking acceptance. Trust and resistance to change also have significant impact on the attitude towards the likelihood of adopting online banking.

  19. An Empirical Assessment of a Technology Acceptance Model for Apps in Medical Education.

    Science.gov (United States)

    Briz-Ponce, Laura; García-Peñalvo, Francisco José

    2015-11-01

    The evolution and the growth of mobile applications ("apps") in our society is a reality. This general trend is still upward and the app use has also penetrated the medical education community. However, there is a lot of unawareness of the students' and professionals' point of view about introducing "apps" within Medical School curriculum. The aim of this research is to design, implement and verify that the Technology Acceptance Model (TAM) can be employed to measure and explain the acceptance of mobile technology and "apps" within Medical Education. The methodology was based on a survey distributed to students and medical professionals from University of Salamanca. This model explains 46.7% of behavioral intention to use mobile devise or "apps" for learning and will help us to justify and understand the current situation of introducing "apps" into the Medical School curriculum.

  20. A Behavioral Model of Managerial Perspectives Regarding Technology Acceptance in Building Energy Management Systems

    Directory of Open Access Journals (Sweden)

    Jacky Chin

    2016-07-01

    Full Text Available The Building Energy Management System (BEMS, a well-known system that has been implemented in some energy corporations, has become attractive to many companies seeking to better monitor their energy consumption efficiency. This study investigated the external factors that influence acceptance of the BEMS from managerial perspectives. An extended model based on the Technology Acceptance Model (TAM was created to evaluate the implementation of the BEMS in the manufacturing industries. A structural equation modeling (SEM approach was used to analyze the model by adopting compatibility, features, technology complexity, and perceived risk as the external variables, and integrating the five dimensions of perceived ease of use, perceived usefulness, attitude, user satisfaction, and behavioral intention. The analysis results indicated that the external factors positively influenced users’ behavioral intention to use the BEMS through expected satisfaction, perceived ease of use, and perceived usefulness. Suggestions for BEMS developers are provided as well.

  1. User acceptance of E-Government Services Based on TRAM model

    Science.gov (United States)

    Adiyarta, K.; Napitupulu, D.; Nurdianto, H.; Rahim, R.; Ahmar, A.

    2018-05-01

    Developing country mostly left behind in adopting e-Government system. Miss-interpretation is assuming e-Government only about the application of technology made fail implementation. It is a whole philosophy that explores a human-citizen centered aspect in organized societies. Further, successful information system determined by user acceptance. Therefore, the evaluation of the performance of e-Government is one of the basic objectives of current government reformation. The research focus is to identify and explore the extent of user acceptance toward e-Government system. The research methodology used in this research is survey based on a questionnaire with TRAM approach and distributed to 230 respondents as customers that had been using e-Government services provided by X institution. The result of the study showed that the personality traits of TR significantly influenced cognitive dimensions of TAM. Through empirical demonstrations indicated that the TRI was said to be antecedents to TAM. The optimism dimension had higher coefficient among others, exhibit the technology users convince that the new technology will improve their productivity, while discomfort had no impact since the users have no doubt or hesitate to use technology.

  2. Determinants of the Acceptance of Sustainable Production Strategies among Dairy Farmers: Development and Testing of a Modified Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Simona Naspetti

    2017-10-01

    Full Text Available An extended version of the Technology Acceptance Model (TAM was applied by means of Structural Equation Modelling to testing various hypotheses on attitudes and intentions of dairy farmers towards three novel sustainable production strategies, as well as the influence of organic practices and collaborative behaviours, such as information sharing with supply-chain partners. Data on the acceptance of three sustainable production strategies, namely ‘Agro-forestry’, ‘Alternative protein source’, and ‘Prolonged maternal feeding’ were collected by a survey of dairy farmers in six European Union (EU countries (Austria, Belgium, Denmark, Finland, Italy, United Kingdom. We found that perceived usefulness is the key determinant of acceptance, while the intention to adopt a sustainable production strategy may derive from the influence of opinions (and behaviours of relevant others (e.g., leading dairy farmers, family members, advisors showing the role of interactions among farmers and other stakeholders in the adoption of innovations. Finally, the perceived usefulness of all of the investigated strategies is higher for organic farmers, while collaborative patterns reduce the impact of subjective norm on usefulness and overall acceptance. Our findings should encourage policy makers to consider the important role of supply chain management practices, including collaboration, to enhance the sustainability of dairy farming systems.

  3. Integrating social capital theory, social cognitive theory, and the technology acceptance model to explore a behavioral model of telehealth systems.

    Science.gov (United States)

    Tsai, Chung-Hung

    2014-05-07

    Telehealth has become an increasingly applied solution to delivering health care to rural and underserved areas by remote health care professionals. This study integrated social capital theory, social cognitive theory, and the technology acceptance model (TAM) to develop a comprehensive behavioral model for analyzing the relationships among social capital factors (social capital theory), technological factors (TAM), and system self-efficacy (social cognitive theory) in telehealth. The proposed framework was validated with 365 respondents from Nantou County, located in Central Taiwan. Structural equation modeling (SEM) was used to assess the causal relationships that were hypothesized in the proposed model. The finding indicates that elderly residents generally reported positive perceptions toward the telehealth system. Generally, the findings show that social capital factors (social trust, institutional trust, and social participation) significantly positively affect the technological factors (perceived ease of use and perceived usefulness respectively), which influenced usage intention. This study also confirmed that system self-efficacy was the salient antecedent of perceived ease of use. In addition, regarding the samples, the proposed model fitted considerably well. The proposed integrative psychosocial-technological model may serve as a theoretical basis for future research and can also offer empirical foresight to practitioners and researchers in the health departments of governments, hospitals, and rural communities.

  4. Integrating Social Capital Theory, Social Cognitive Theory, and the Technology Acceptance Model to Explore a Behavioral Model of Telehealth Systems

    Directory of Open Access Journals (Sweden)

    Chung-Hung Tsai

    2014-05-01

    Full Text Available Telehealth has become an increasingly applied solution to delivering health care to rural and underserved areas by remote health care professionals. This study integrated social capital theory, social cognitive theory, and the technology acceptance model (TAM to develop a comprehensive behavioral model for analyzing the relationships among social capital factors (social capital theory, technological factors (TAM, and system self-efficacy (social cognitive theory in telehealth. The proposed framework was validated with 365 respondents from Nantou County, located in Central Taiwan. Structural equation modeling (SEM was used to assess the causal relationships that were hypothesized in the proposed model. The finding indicates that elderly residents generally reported positive perceptions toward the telehealth system. Generally, the findings show that social capital factors (social trust, institutional trust, and social participation significantly positively affect the technological factors (perceived ease of use and perceived usefulness respectively, which influenced usage intention. This study also confirmed that system self-efficacy was the salient antecedent of perceived ease of use. In addition, regarding the samples, the proposed model fitted considerably well. The proposed integrative psychosocial-technological model may serve as a theoretical basis for future research and can also offer empirical foresight to practitioners and researchers in the health departments of governments, hospitals, and rural communities.

  5. The Effects of Technology Innovativeness and System Exposure on Student Acceptance of E-textbooks

    Directory of Open Access Journals (Sweden)

    Madison N. Ngafeeson

    2015-01-01

    Full Text Available The efforts of educators in the last three decades have, among other things, focused on the use of information technology (IT in education. It has become commonplace to view information systems both as an effective carrier of course content as well as a cost-effective tool to improve student learning outcomes. One of such technologies is the e-book. Decision-makers in the education field need make sense of this technological transformation. However, despite the growing popularity of e-books in higher education, its adoption by students is yet to be crystalized. This study exploits the technology acceptance model (TAM framework to examine student acceptance of e-textbooks as “internally” impacted by technology innovativeness and “externally” influenced by system exposure. The results showed that students’ technology innovativeness is associated with student acceptance of e-textbooks and that system exposure was a strong moderator of the TAM relationships. The findings suggest that students’ openness to new technology, in general, is likely to positively affect the adoption of a specific new instructional technology. Additionally, system exposure was found to be a significant moderator of the TAM relationships. It is concluded that students’ technology innovativeness and system exposure must therefore be factored into instructional technology usage decision-making models.

  6. Students' Acceptance of an Educational Videos Platform: A Study in A Portuguese University

    Science.gov (United States)

    Costa, Carolina; Alvelos, Helena; Teixeira, Leonor

    2018-01-01

    The Educast is an educational videos' platform that captures simultaneously video and digital support materials. This paper presents a study on the acceptance of Educast, by students, using the Technology Acceptance Model--TAM. The data was collected through a questionnaire applied to 54 students which results were analyzed using descriptive…

  7. User adoption of mobile commerce in Bangladesh: Integrating perceived risk, perceived cost and personal awareness with TAM

    Directory of Open Access Journals (Sweden)

    Mohammed Mizanur Rahman

    2017-04-01

    Full Text Available This paper develops and tests a model for predicting user adoption of mobile commerce (i.e. e-commerce using mobile phones in developing countries. The model takes up the Technology Acceptance Model (TAM determinants of perceived usefulness and perceived ease of use, and extends these through the inclusion of three further determinants: perceived risk, perceived cost and personal awareness to enable prediction of the likelihood of mobile commerce adoption by users in the developing world. 575 usable surveys were gathered from the urban, semi-urban and rural areas of Bangladesh. Perceived risk and perceived usefulness were found to be the most influential factors effecting mobile commerce adoption, while the effect of perceived ease of use and personal awareness was found to be low although significant. The study reconfirmed the need of extending TAM model, in the context of mobile commerce, to address both itrs transactional and non-transactional components. Service providers need to ensure high levels of security and privacy to reduce userrs perceptions of risk. Mobile commerce services and technologies should be upgraded to world standard to make them more useful to users.

  8. TAM receptors in apoptotic cell clearance, autoimmunity, and cancer.

    Science.gov (United States)

    Nguyen, Khanh-Quynh; Tsou, Wen-I; Kotenko, Sergei; Birge, Raymond B

    2013-08-01

    Receptor tyrosine kinases, Tyro-3, Axl and Mer, collectively designated as TAM, are involved in the clearance of apoptotic cells. TAM ligands, Gas6 and Protein S, bind to the surfaces of apoptotic cells, and at the same time, interact directly with TAM expressed on phagocytes, impacting the engulfment and clearance of apoptotic cells and debris. The well-tuned and balanced actions of TAM may affect a variety of human pathologies including autoimmunity, retinal degeneration, and cancer. This article emphasizes some of the emerging findings and mechanistic insights into TAM functions that are clinically relevant and possibly therapeutically targeted.

  9. 76 FR 47296 - Transit Asset Management (TAM) Pilot Program Funds

    Science.gov (United States)

    2011-08-04

    ... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Transit Asset Management (TAM) Pilot... supplemented by Bus Discretionary funds in support of the Transit Asset Management (TAM) Pilot Program, which was announced in the TAM Program Notice of Funding Availability on November 19, 2010. The TAM program...

  10. A Conceptual Model of eLearning Adoption

    Directory of Open Access Journals (Sweden)

    Muneer Abbad

    2011-05-01

    Full Text Available Internet-based learning systems are being used in many universities and firms but their adoption requires a solid understanding of the user acceptance processes. The technology acceptance model (TAM has been used to test the acceptance of various technologies and software within an e-learning context. This research aims to discuss the main factors of a successful e-learning adoption by students. A conceptual research framework of e-learning adoption is proposed based on the TAM model.

  11. OTM Machine Acceptance: In the Arab Culture

    Science.gov (United States)

    Rashed, Abdullah; Santos, Henrique

    Basically, neglecting the human factor is one of the main reasons for system failures or for technology rejection, even when important technologies are considered. Biometrics mostly have the characteristics needed for effortless acceptance, such as easiness and usefulness, that are essential pillars of acceptance models such as TAM (technology acceptance model). However, it should be investigated. Many studies have been carried out to research the issues of technology acceptance in different cultures, especially the western culture. Arabic culture lacks these types of studies with few publications in this field. This paper introduces a new biometric interface for ATM machines. This interface depends on a promising biometrics which is odour. To discover the acceptance of this biometrics, we distributed a questionnaire via a web site and called for participation in the Arab Area and found that most respondents would accept to use odour.

  12. TAM receptor knockout mice are susceptible to retinal autoimmune induction.

    Science.gov (United States)

    Ye, Fei; Li, Qiutang; Ke, Yan; Lu, Qingjun; Han, Lixia; Kaplan, Henry J; Shao, Hui; Lu, Qingxian

    2011-06-16

    TAM receptors are expressed mainly by dendritic cells and macrophages in the immune system, and mice lacking TAM receptors develop systemic autoimmune diseases because of inefficient negative control of the cytokine signaling in those cells. This study aims to test the susceptibility of the TAM triple knockout (tko) mice to the retina-specific autoantigen to develop experimental autoimmune uveoretinitis (EAU). TAM tko mice that were or were not immunized with interphotoreceptor retinoid-binding protein (IRBP) peptides were evaluated for retinal infiltration of the macrophages and CD3(+) T cells by immunohistochemistry, spontaneous activation of CD4(+) T cells, and memory T cells by flow cytometry and proliferation of IRBP-specific CD4(+) T cells by [(3)H]thymidine incorporation assay. Ocular inflammation induced by IRBP peptide immunization and specific T cell transfer were observed clinically by funduscopy and confirmed by histology. Tko mice were found to have less naive, but more activated, memory T cells, among which were exhibited high sensitivity to ocular IRBP autoantigens. Immunization with a low dose of IRBP and adoptive transfer of small numbers of IRBP-specific T cells from immunized tko mice caused the infiltration of lymphocytes, including CD3(+) T cells, into the tko retina. Mice without TAM receptor spontaneously develop IRBP-specific CD4(+) T cells and are more susceptible to retinal autoantigen immunization. This TAM knockout mouse line provides an animal model with which to study the role of antigen-presenting cells in the development of T cell-mediated uveitis.

  13. TAM 2.0: tool for MicroRNA set analysis.

    Science.gov (United States)

    Li, Jianwei; Han, Xiaofen; Wan, Yanping; Zhang, Shan; Zhao, Yingshu; Fan, Rui; Cui, Qinghua; Zhou, Yuan

    2018-06-06

    With the rapid accumulation of high-throughput microRNA (miRNA) expression profile, the up-to-date resource for analyzing the functional and disease associations of miRNAs is increasingly demanded. We here describe the updated server TAM 2.0 for miRNA set enrichment analysis. Through manual curation of over 9000 papers, a more than two-fold growth of reference miRNA sets has been achieved in comparison with previous TAM, which covers 9945 and 1584 newly collected miRNA-disease and miRNA-function associations, respectively. Moreover, TAM 2.0 allows users not only to test the functional and disease annotations of miRNAs by overrepresentation analysis, but also to compare the input de-regulated miRNAs with those de-regulated in other disease conditions via correlation analysis. Finally, the functions for miRNA set query and result visualization are also enabled in the TAM 2.0 server to facilitate the community. The TAM 2.0 web server is freely accessible at http://www.scse.hebut.edu.cn/tam/ or http://www.lirmed.com/tam2/.

  14. Discussions about acceptance of the free software for management and creation of referencial database for papers

    Directory of Open Access Journals (Sweden)

    Flavio Ribeiro Córdula

    2016-03-01

    Full Text Available Objective. This research aimed to determine the degree of acceptance, by the use of the Technology Acceptance Model - TAM, of the developed software, which allows the construction and database management of scientific articles aimed at assisting in the dissemination and retrieval of stored scientific production in digital media. Method. The research is characterized as quantitative, since the TAM, which guided this study is essentially quantitative. A questionnaire developed according to TAM guidelines was used as a tool for data collection. Results. It was possible to verify that this software, despite the need of fixes and improvements inherent to this type of tool, obtained a relevant degree of acceptance by the sample studied. Conciderations. It also should be noted that although this research has been directed to scholars in the field of information science, the idea that justified the creation of the software used in this study might contribute to the development of science in any field of knowledge, aiming at the optimization results of a search conducted in a specialized database can provide.

  15. 75 FR 70966 - Transit Asset Management (TAM) Pilot Program

    Science.gov (United States)

    2010-11-19

    ... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Transit Asset Management (TAM) Pilot... Management (TAM) systems and ``best practices'', which can be replicated to improve transportation asset... with asset management system suppliers; however the official proposer must be a public agency. The TAM...

  16. A Technology Acceptance Model for Inter-Organisational Electronic Medical Records Systems

    Directory of Open Access Journals (Sweden)

    Jocelyn Handy

    2001-11-01

    Full Text Available This article reports the findings of the first stage of an ongoing, longitudinal study into the implementation of an interorganisational electronic medical records (EMR system. The study adapted and expanded Davis' (1993 technology acceptance model (TAM to investigate the attitudes of primary care practitioners towards a proposed system for maternity patients. All doctors and midwives holding maternity care contracts with a large urban hospital in New Zealand were sent a questionnaire soliciting their views on a planned EMR system linking the hospital and the primary care sectors. The results showed that whilst Davis' two key factors of perceived ease of use and perceived usefulness were important to medical professionals, another key factor, perceived system acceptability, which concerns control and management of information is vitally important to the acceptance of the system. The study also showed that the two groups of professionals had differing requirements due to different levels of experience and practice computerisation. Finally, the research highlights a number of wider organisational issues particularly relevant to the use of inter organisational systems in general and healthcare systems in particular.

  17. TAM Receptors Are Not Required for Zika Virus Infection in Mice

    Directory of Open Access Journals (Sweden)

    Andrew K. Hastings

    2017-04-01

    Full Text Available Summary: Tyro3, Axl, and Mertk (TAM receptors are candidate entry receptors for infection with the Zika virus (ZIKV, an emerging flavivirus of global public health concern. To investigate the requirement of TAM receptors for ZIKV infection, we used several routes of viral inoculation and compared viral replication in wild-type versus Axl−/−, Mertk−/−, Axl−/−Mertk−/−, and Axl−/−Tyro3−/− mice in various organs. Pregnant and non-pregnant mice treated with interferon-α-receptor (IFNAR-blocking (MAR1-5A3 antibody and infected subcutaneously with ZIKV showed no reliance on TAMs for infection. In the absence of IFNAR-blocking antibody, adult female mice challenged intravaginally with ZIKV showed no difference in mucosal viral titers. Similarly, in young mice that were infected with ZIKV intracranially or intraperitoneally, ZIKV replication occurred in the absence of TAM receptors, and no differences in cell tropism were observed. These findings indicate that, in mice, TAM receptors are not required for ZIKV entry and infection. : TAM receptors have been implicated as entry receptors for the Zika virus. In this study, Hastings et al. used genetic knockout mouse models to demonstrate that they are not necessary for the infection of mice via multiple routes of viral challenge. These results suggest the existence of redundant entry receptors for ZIKV in mice. Keywords: viral entry, flavivirus, neurotropic virus, CNS, pregnancy, congenital infection

  18. Synthesis of a radioiodinated antiestrogen glucuronide compound (TAM-G)

    International Nuclear Information System (INIS)

    Fazilet Zumrut Biber Muftuler; Perihan Unak; Cigdem Ichedef; Ilknur Demir

    2011-01-01

    Tamoxifen [TAM; ([Z]-2-[4-(1,2-diphenyl-1-di-butenyl)-phenoxy]-N,N-dimethylethanamine) has been used as an antiestrogen drug for treatment and prevention of human breast cancer. The aim of this study is conjugation of hydrophilic glucuronic acid to the starting substance TAM and labeling with 131 I using iodogen as oxidizing agent. The reactions are completed in three steps, including enzymatic reaction, with the following sub-steps; preparation of microsomal fraction from rat liver and subsequent purification of UDP-glucuronyl transferase (UDPGT), estimation of protein amount in microsomal samples and glucuronidation reaction. Synthesized glucuronide derivative (TAM-G) was purified using high performance liquid chromatography (HPLC). Mass spectroscopy of cold standard showed that the labeling most probably occurs in ortho position to the aromatic ring containing the ether group of TAM-G as expected. Radiochemical yield of the 131 I labeled TAM-G ([ 131 I]TAM-G) is determined by using Thin Layer Radio Chromatography (TLRC). The radiopharmaceutical potential of [ 131 I]TAM-G is examined by biodistribution studies that is run on normal female Albino Wistar rats. According to biodistribution results 131 I labeled TAM-G may be proposed as a new antiestrogen glucuronide imaging agent for breast and uterus. Electronic supplementary material. The online version of this article (doi:10.1007/s10967-010-0932-7) contains supplementary material, which is available to authorized users. (author)

  19. Testing the Technology Acceptance Model: HIV case managers' intention to use a continuity of care record with context-specific links.

    Science.gov (United States)

    Schnall, Rebecca; Bakken, Suzanne

    2011-09-01

    To assess the applicability of the Technology Acceptance Model (TAM) constructs in explaining HIV case managers' behavioural intention to use a continuity of care record (CCR) with context-specific links designed to meet their information needs. Data were collected from 94 case managers who provide care to persons living with HIV (PLWH) using an online survey comprising three components: (1) demographic information: age, gender, ethnicity, race, Internet usage and computer experience; (2) mock-up of CCR with context-specific links; and items related to TAM constructs. Data analysis included: principal components factor analysis (PCA), assessment of internal consistency reliability and univariate and multivariate analysis. PCA extracted three factors (Perceived Ease of Use, Perceived Usefulness and Perceived Barriers to Use), explained variance = 84.9%, Cronbach's ά = 0.69-0.91. In a linear regression model, Perceived Ease of Use, Perceived Usefulness and Perceived Barriers to Use explained 43.6% (p Technology assessed.

  20. Which User of technology? Perspectivising the UTAUT model by application of the SFL language Pronoun System towards a systems perspective of technology acceptance and use

    Directory of Open Access Journals (Sweden)

    Cheryl Marie Cordeiro

    2018-04-01

    Full Text Available This study applies systemic functional linguistics (SFL as complementary framework of analysis of technology acceptance models (TAMs. The purpose is to bridge research methodology language in international business (IB studies and engineering management science. Currently TAMs and its consolidated version, the Unified Theory of Acceptance and Use of Technology (UTAUT provides for a typology of one user in one context scenario. The need for the UTAUT model to account for multiple users in multiple work contexts in a single framework of analysis was foregrounded in the study of the workflow processes of a remote services business model of a European founded multinational business enterprise (MBE with regards to its (i intra-firm improvements in managing remote services cases, and its (ii extra-firm selling of life cycle management remote services contracts. The Enterprise has global operations in over 100 countries, of which this study focused on its European operations of improving the quality of remote services for the marine industry. Through an application of SFL unto UTAUT, this study illustrates how multiple users in multiple contexts can be analysed simultaneously, and whose behaviours can be accounted for in a single framework of analysis. The combined SFL UTAUT model addresses the initial statisticity of the UTAUT model, whilst at the same time, expands upon current theoretical perspectives of technology use and acceptance that can be applied in practice.

  1. The User Characteristics Effects to Smart Board Usage on Technology Acceptance Model Variables: The Sample of Bartin Highschool Teachers

    Directory of Open Access Journals (Sweden)

    Yaşar Akça

    2017-02-01

    Full Text Available A new technology’s acceptance also gets shaped according to users’ features, expectations and perceptions. Technology Acceptance Model (TAM that developed by Davis (1989, defends that there are perceived usefulness and perceived ease of use variables to determinants of a new technology’s usage by user. These perceptions predict the user’s behavior and explain it. The smart board that has common usage in modern classrooms provides effectiveness at education and learning activities. Teachers who use smart boards can present more effectively. This situation increases the teacher’s productivity and student’s learning success and improvement the class’s education quality. Existence of the smart board in the classroom motivates all by self. Thanks to this technological device, it is easy to access internet based study materials. This study’s purpose is testing the user features explanation power effects to usage of smart board, which is a new education tool, based on TAM variables. For performing of the research, surveys have actualized with 24 teachers at Bartin High School with smart boards. Survey data have been interpreted based on correlation, factor and regression analyses in WarpPLS 5.0. Results have been concluded from analyse strongly supports research model.

  2. Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome.

    Science.gov (United States)

    Saida, Satoshi; Watanabe, Ken-ichiro; Sato-Otsubo, Aiko; Terui, Kiminori; Yoshida, Kenichi; Okuno, Yusuke; Toki, Tsutomu; Wang, RuNan; Shiraishi, Yuichi; Miyano, Satoru; Kato, Itaru; Morishima, Tatsuya; Fujino, Hisanori; Umeda, Katsutsugu; Hiramatsu, Hidefumi; Adachi, Souichi; Ito, Etsuro; Ogawa, Seishi; Ito, Mamoru; Nakahata, Tatsutoshi; Heike, Toshio

    2013-05-23

    Transient abnormal myelopoiesis (TAM) is a clonal preleukemic disorder that progresses to myeloid leukemia of Down syndrome (ML-DS) through the accumulation of genetic alterations. To investigate the mechanism of leukemogenesis in this disorder, a xenograft model of TAM was established using NOD/Shi-scid, interleukin (IL)-2Rγ(null) mice. Serial engraftment after transplantation of cells from a TAM patient who developed ML-DS a year later demonstrated their self-renewal capacity. A GATA1 mutation and no copy number alterations (CNAs) were detected in the primary patient sample by conventional genomic sequencing and CNA profiling. However, in serial transplantations, engrafted TAM-derived cells showed the emergence of divergent subclones with another GATA1 mutation and various CNAs, including a 16q deletion and 1q gain, which are clinically associated with ML-DS. Detailed genomic analysis identified minor subclones with a 16q deletion or this distinct GATA1 mutation in the primary patient sample. These results suggest that genetically heterogeneous subclones with varying leukemia-initiating potential already exist in the neonatal TAM phase, and ML-DS may develop from a pool of such minor clones through clonal selection. Our xenograft model of TAM may provide unique insight into the evolutionary process of leukemia.

  3. Empirical Examination of Users’ Adoption of the Sharing Economy in China Using an Expanded Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Yupeng Liu

    2018-04-01

    Full Text Available With the popularity of sharing-based applications such as bicycle and car sharing, the sharing economy has attracted considerable global attention. The factors that affect users’ adoption of the sharing economy must be identified to facilitate the promotion of low-carbon lifestyles and help enterprises attract more active users. By employing the technology acceptance model (TAM and herd behavior, this study implemented an expanded TAM and identified several factors affecting behavioral intention (BI toward the sharing economy. A questionnaire was used to obtain the data, which were analyzed through structural equation modeling. The results revealed that perceived usefulness (PU and perceived ease of use (PEOU are the main factors affecting BI. Moreover, trust (TRU was identified as a mediator of subjective norm (SN and PEOU. Imitating others (IMI affects BI, and SN affects TRU, PU, and PEOU. Gender moderates SN and IMI. This paper indicates that to improve users’ BI, enterprises should enhance PU, PEOU, and TRU; cooperate with organizations to enhance SN; and guide potential users to imitate others.

  4. The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.

    Science.gov (United States)

    Shafit-Zagardo, Bridget; Gruber, Ross C; DuBois, Juwen C

    2018-03-04

    Tyro3, Axl, and Mertk, referred to as the TAM family of receptor tyrosine kinases, are instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors interact with multiple signaling molecules to regulate cell migration, survival, phagocytosis and clearance of metabolic products and cell debris called efferocytosis. The TAMs also function as rheostats to reduce the expression of proinflammatory molecules and prevent autoimmunity. All three TAM receptors are activated in a concentration-dependent manner by the vitamin K-dependent growth arrest-specific protein 6 (Gas6). Gas6 and the TAMs are abundantly expressed in the nervous system. Gas6, secreted by neurons and endothelial cells, is the sole ligand for Axl. ProteinS1 (ProS1), another vitamin K-dependent protein functions mainly as an anti-coagulant, and independent of this function can activate Tyro3 and Mertk, but not Axl. This review will focus on the role of the TAM receptors and their ligands in the nervous system. We highlight studies that explore the function of TAM signaling in myelination, the visual cortex, neural cancers, and multiple sclerosis (MS) using Gas6 -/- and TAM mutant mice models. Copyright © 2018. Published by Elsevier Inc.

  5. Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice.

    Science.gov (United States)

    Chen, Yongmei; Wang, Huizhen; Qi, Nan; Wu, Hui; Xiong, Weipeng; Ma, Jing; Lu, Qingxian; Han, Daishu

    2009-10-01

    Mice lacking TYRO3, AXL and MER (TAM) receptor tyrosine kinases (RTKs) are male sterile. The mechanism of TAM RTKs in regulating male fertility remains unknown. In this study, we analyzed in more detail the testicular phenotype of TAM triple mutant (TAM(-/-)) mice with an effort to understand the mechanism. We demonstrate that the three TAM RTKs cooperatively regulate male fertility, and MER appears to be more important than AXL and TYRO3. TAM(-/-) testes showed a progressive loss of germ cells from elongated spermatids to spermatogonia. Young adult TAM(-/-) mice exhibited oligo-astheno-teratozoospermia and various morphological malformations of sperm cells. As the mice aged, the germ cells were eventually depleted from the seminiferous tubules. Furthermore, we found that TAM(-/-) Sertoli cells have an impaired phagocytic activity and a large number of differentially expressed genes compared to wild-type controls. By contrast, the function of Leydig cells was not apparently affected by the mutation of TAM RTKs. Therefore, we conclude that the suboptimal function of Sertoli cells leads to the impaired spermatogenesis in TAM(-/-) mice. The results provide novel insight into the mechanism of TAM RTKs in regulating male fertility.

  6. Pengaruh Internet Banking Terhadap Minat Nasabah Dalam Bertransaksi Dengan Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Evi Yani

    2018-04-01

    Full Text Available Abstrak Internet banking merupakan salah satu teknologi transaksi perbankan yang ditawarkan oleh bank-bank komersial di Indonesia untuk para nasabah dalam melakukan transaksi seperti transfer, pembayaran, dan sebagainya dengan mudah dan cepat. Sebagian besar nasabah lebih memilih melakukan transaksi dengan internet banking dibandingkan harus mendatangi ke bank, hal ini berdasarkan OJK (Otoritas Jasa Keuangan mencatat bahwa jumlah pengguna e-banking meningkat sebesar 270 % dari 13,6 juta nasabah pada tahun 2012 menjadi 50,4 juta nasabah pada tahun 2016. Peningkatan terjadi dikarenakan adanya kebutuhan masyarakat dalam memanfaatkan teknologi. Penelitian ini bertujuan untuk mengetahui pengaruh internet banking terhadap minat nasabah dengan TAM (Technology Acceptance Modelyaitu persepsi kemudahan dan persepsi kegunaan. Metode pengumpulan data dengan kuesioner secara random sampling sebanyak 104 responden nasabah BRI dengan menggunakan skala Likert, pengujian data melalui uji validitas, reabilitas, normalitas, linearitas, uji regresi dan koefisien determinasi dan pengolahan kuesioner dengan SPSS. Hasil penelitian menunjukkan bahwa persepsi kemanfaatan penggunaan internet banking terhadap persepsi kemudahan dalam bertransaksi bagi nasabah Bank BRI.Semakin banyak manfaat yang dirasakan para nasabah,maka akan mempengaruhi kemudahan bagi nasabah setiap bertransaksi menggunakan internet banking. Kata Kunci: Internet banking, Technology Acceptance Model, persepsi kemudahan, persepsi kegunaan. Abstract Internet banking is one of the banking transaction technology offered by commercial banks in Indonesia for customers in transactions such as transfers, payments, and so on easily and quickly. Most customers prefer to make transactions with internet banking rather than go to banks, according to OJK (Financial Services Authority noting that the number of e-banking users increased by 270% from 13.6 million customers in 2012 to 50.4 million customers in the year

  7. Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy.

    Science.gov (United States)

    Ochodnicky, Peter; Lattenist, Lionel; Ahdi, Mohamed; Kers, Jesper; Uil, Melissa; Claessen, Nike; Leemans, Jaklien C; Florquin, Sandrine; Meijers, Joost C M; Gerdes, Victor E A; Roelofs, Joris J T H

    2017-09-01

    TAM receptors (Tyro3, Axl, and Mer) have been implicated in innate immunity. Circulating TAM receptor soluble forms (sTyro3, sAxl, sMer) are related to autoimmune disorders. We investigated TAM and their ligand protein S in patients with diabetes. Urinary and plasma levels of protein S, sTyro3, sAxl, and sMer were determined in 126 patients with diabetes assigned to a normoalbuminuric or macroalbuminuric (urinary albumin excretion 300 mg/24 hours, respectively) study group and 18 healthy volunteers. TAM and protein S immunostaining was performed on kidney biopsy specimens from patients with diabetic nephropathy (n = 9) and controls (n = 6). TAM expression and shedding by tubular epithelial cells were investigated by PCR and enzyme-linked immunosorbent assay in an in vitro diabetes model. Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary sTyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer expression in diabetic nephropathy tissue and glomerular depositions of protein S. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer mRNA and increased shedding of sTyro3 and sMer. Renal injury in diabetes is associated with elevated systemic and urine levels of sMer and sTyro3. This is the first study reporting excretion of sTAM receptors in urine, identifying the kidney as a source of sTAM. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  8. Exploring Electronic Communication Modes Between Iraqi Faculty and Students of Pharmacy Schools Using the Technology Acceptance Model.

    Science.gov (United States)

    Al-Jumaili, Ali Azeez; Al-Rekabi, Mohammed D; Alsawad, Oday S; Allela, Omer Q B; Carnahan, Ryan; Saaed, Hiwa; Naqishbandi, Alaadin; Kadhim, Dheyaa J; Sorofman, Bernard

    2017-06-01

    Objective. To explore for the first time the extent to which Iraqi pharmacy students and faculty use Facebook and university email for academic communications, and to examine factors influencing utilization within the framework of the Technology Acceptance Model (TAM). Methods. An electronic survey was administered to convenience samples of students and faculty of six Iraqi public schools and colleges of pharmacy in 2015. Results. Responses included 489 student and 128 faculty usable surveys. Both students and faculty use Facebook more than university email for academic communications. Less than a third of the faculty used university email. Students used Facebook for academic purposes twice as much as faculty. Conclusion. Absence of university email in Iraqi schools and colleges of pharmacy makes Facebook essential for faculty-student communications. The majority (71.1% to 82%) of respondents perceived that Facebook was easy to use. Three TAM variables (intention to use, attitude toward use and perceived usefulness) had significant positive associations with actual use of both Facebook messaging and university email.

  9. An extension of technology acceptance model to determine factors that influence the intention to use electronic collection system in Nigerian federal hospitals

    Science.gov (United States)

    Kabir, Muhammad Auwal; Saidin, Siti Zabedah; Ahmi, Aidi

    2017-10-01

    The aim of this paper is to develop a conceptual framework that would be used in determining the factors that influence the behavioral intention to use electronic collection system in federal government owned hospitals in Nigeria. The framework is supported by Technology Acceptance Model (TAM) as the underlying theory of the study. Past literature on individual user intention were thoroughly reviewed and found that TAM is fit appropriate in explaining the phenomenon under study. Based on the reviewed literature, it is expected that perceived usefulness and perceived ease of use will influence the intention of users (employees) to use e-collection system in the performance of their job tasks in Nigerian federal hospitals. In other words, users with higher perception on the system's usefulness and its ease of use are more likely to express their interest and willingness to use the system. In addition, the study has extended TAM with facilitating conditions construct and the research is expected to discover the level of its influence on behavioral intention to use e-collection system.

  10. Factors Affecting M-commerce Adoption in Oman using Technology Acceptance Modeling Approach

    Directory of Open Access Journals (Sweden)

    Syed Jafar Naqvi

    2014-11-01

    Full Text Available The advancement in mobile technologies has influenced many countries to adopt mobile services in their private and public organizations including Oman. M-commerce services are growing rapidly with the exponential growth of mobile devices, technologies and networks. Hence, many business organizations private or public use them to improve revenue, reduce costs, maintain their competitive edge and achieve a level of high efficiency. Although there were many M-commerce services introduced, it was hard to find evidence of any study conducted to determine their successes or failures. This study is an attempt to explore the factors affecting the adoption of M-commerce services in Oman using the Technology Acceptance Model (TAM approach.

  11. APLIKASI TECHNOLOGY ACCEPTANCE MODEL PADA SISTEM INFORMASI MANAJEMEN RUMAH SAKIT DI RUMAH SAKIT ORTOPEDI PROF. DR. R. SOEHARSO SURAKARTA

    OpenAIRE

    Supriyanti Supriyanti; Muhammad Cholil

    2017-01-01

    The purpose of this study to apply the Technology Acceptance Model (TAM) on the Hospital Management Information System. This research is important because changes in hospital management information system (SIMRS) of the old system in collaboration with third parties to the new system is a standalone system that was developed by the IT team RSO Prof. dr. R. Soeharso requires a process of transition, which for some employees lead to conflict in the process of adaptation. This stu...

  12. Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression.

    Science.gov (United States)

    Kasikara, Canan; Kumar, Sushil; Kimani, Stanley; Tsou, Wen-I; Geng, Ke; Davra, Viralkumar; Sriram, Ganapathy; Devoe, Connor; Nguyen, Khanh-Quynh N; Antes, Anita; Krantz, Allen; Rymarczyk, Grzegorz; Wilczynski, Andrzej; Empig, Cyril; Freimark, Bruce; Gray, Michael; Schlunegger, Kyle; Hutchins, Jeff; Kotenko, Sergei V; Birge, Raymond B

    2017-06-01

    Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis). TAM receptors are overexpressed in a vast array of tumor types, whereby the level of expression correlates with the tumor grade and the emergence of chemo- and radioresistance to targeted therapeutics, but also have been implicated as inhibitory receptors on infiltrating myeloid-derived cells in the tumor microenvironment that can suppress host antitumor immunity. In the present study, we utilized TAM-IFNγR1 reporter lines and expressed TAM receptors in a variety of epithelial cell model systems to show that each TAM receptor has a unique pattern of activation by Gas6 or ProS, as well as unique dependency for PS on apoptotic cells and PS liposomes for activity. In addition, we leveraged this system to engineer epithelial cells that express wild-type TAM receptors and show that although each receptor can promote PS-mediated efferocytosis, AKT-mediated chemoresistance, as well as upregulate the immune checkpoint molecule PD-L1 on tumor cells, Mertk is most dominant in the aforementioned pathways. Functionally, TAM receptor-mediated efferocytosis could be partially blocked by PS-targeting antibody 11.31 and Annexin V, demonstrating the existence of a PS/PS receptor (i.e., TAM receptor)/PD-L1 axis that operates in epithelial cells to foster immune escape. These data provide a rationale that PS-targeting, anti-TAM receptor, and anti-PD-L1-based therapeutics will have merit as combinatorial checkpoint inhibitors. Implications: Many tumor cells are known to upregulate the immune checkpoint inhibitor PD-L1. This study demonstrates a role for PS and TAM receptors in the regulation of PD-L1 on cancer cells. Mol Cancer Res; 15(6); 753-64. ©2017 AACR

  13. Extending TAM and IDT to Predict the Adoption of the Internet for B-to-B Marketing Activities: An Empirical Study of UK Companies

    OpenAIRE

    Riyad Eid

    2009-01-01

    There has been considerable Research into the usage of the Internet for Business-to-Business (B-to-B) marketing activities in recent years. The need to understand how and why B-to-B companies utilize the Internet is important for researchers and practitioners alike. This study combines Davis’ model-the Technology Acceptance Model (TAM)- and Roger’s Theory- the Innovation diffusion Theory (IDT) to understand the process of Internet adoption for marketing purposes. It makes a comprehensive ...

  14. Public acceptance of residential solar photovoltaic technology in Malaysia

    Directory of Open Access Journals (Sweden)

    Salman Ahmad

    2017-11-01

    Full Text Available Purpose – Gaining independence from fossil fuels and combating climate change are the main factors to increase the generation of electricity from renewable fuels. Amongst the renewable technologies, solar photovoltaic (PV is believed to have the largest potential. However, the number of people adopting solar PV technologies is still relatively low. Therefore, the purpose of this paper is to examine the household consumers’ acceptance of solar PV technology being installed on their premises. Design/methodology/approach – To examine the solar PV technology acceptance, this study uses technology acceptance model (TAM as a reference framework. A survey was conducted to gather data and to validate the research model. Out of 780 questionnaires distributed across Malaysia, 663 were returned and validated. Findings – The analysis revealed that perceived ease of use, perceived usefulness and attitude to use significantly influenced behavioural intention to use solar PV technology. Research limitations/implications – This study contributes by extending the understanding of public inclination towards the adoption of solar PV technology. Also, this study contributes in identifying the areas which need to be examined further. However, collecting data from urban peninsular Malaysian respondents only limits the generalization of the results. Practical implications – On the policy front, this study reveals that governmental support is needed to trigger PV acceptance. Originality/value – This paper uses TAM to analyse the uptake of solar PV technology in Malaysian context.

  15. Heategevuslik oksjon TAM-galeriis

    Index Scriptorium Estoniae

    2009-01-01

    Tallinnas TAM Galeriis 9. oktoobril koostöös Jõhvi laste ja noorukite rehabilitatsiooni keskusega toimuval heategevuslikul kunstioksjonil tulevad enampakkumisele Endel Saarepuu tööd. Oksjoni tuludest toetatakse HIV-positiivseid lapsi

  16. Evaluating outcomes of computer-based classroom testing: Student acceptance and impact on learning and exam performance.

    Science.gov (United States)

    Zheng, Meixun; Bender, Daniel

    2018-03-13

    Computer-based testing (CBT) has made progress in health sciences education. In 2015, the authors led implementation of a CBT system (ExamSoft) at a dental school in the U.S. Guided by the Technology Acceptance Model (TAM), the purposes of this study were to (a) examine dental students' acceptance of ExamSoft; (b) understand factors impacting acceptance; and (c) evaluate the impact of ExamSoft on students' learning and exam performance. Survey and focus group data revealed that ExamSoft was well accepted by students as a testing tool and acknowledged by most for its potential to support learning. Regression analyses showed that perceived ease of use and perceived usefulness of ExamSoft significantly predicted student acceptance. Prior CBT experience and computer skills did not significantly predict acceptance of ExamSoft. Students reported that ExamSoft promoted learning in the first program year, primarily through timely and rich feedback on examination performance. t-Tests yielded mixed results on whether students performed better on computerized or paper examinations. The study contributes to the literature on CBT and the application of the TAM model in health sciences education. Findings also suggest ways in which health sciences institutions can implement CBT to maximize its potential as an assessment and learning tool.

  17. EVALUATION OF E-MAIL USAGE BY EXTENDED TECHNOLOGY ACCEPTANCE MODEL

    Directory of Open Access Journals (Sweden)

    Savaş Mutlu

    2013-01-01

    Full Text Available This study is performed to evaluate E-mail usage by Extended Technology Acceptance Model (TAM2 and to test the moderation effects of Espoused National Cultural Values between Subjective Norm (SN and E-mail usage Behavioral Intention (BI/Perceived Usefulness (PU. Survey was conducted in Adana Branches of an important Turkish State-Run Bank including 151 participants who have E-mail access for work purposes. As the results of the study; PU and Perceived Ease Of Use (PEOU have positive effects on BI, PEOU and SN both effect PU, Femininity (F shows positive moderating effect on the relationship between SN and PU as well as the relation between SN and BI, Collectivism (C shows positive moderation effect between SN and PU, moderation effect of SN on PU is higher for people who have higher tolerance to uncertainty.

  18. Mechanics IUTAM USNC/TAM a history of people, events, and communities

    CERN Document Server

    Herakovich, Carl T

    2016-01-01

    This book provides a detailed history of the United States National Committee on Theoretical and Applied Mechanics (USNC/TAM) of the US National Academies, the relationship between the USNC/TAM and IUTAM, and a review of the many mechanicians who developed the field over time. It emphasizes the birth and growth of USNC/TAM, the birth and growth of the larger International Union of Theoretical and Applied Mechanics (IUTAM), and explores the work of mechanics from Aristotle to the present. Written by the former Secretary of USNC/TAM, Dr. Carl T. Herakovich of the University of Virginia, the book profiles luminaries of mechanics including Galileo, Newton, Bernoulli, Euler, Cauchy, Prandtl, Einstein, von Kármán, Timoshenko, and in so doing provides insight into centuries of scientific and technologic advance. Profiles the applied mathematicians and engineers who developed the field of mechanics in the context of the establishment of the USNC/TAM and the IUTAM Details the relationship between USNC/TAM and IUTAM ...

  19. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

    Science.gov (United States)

    Meertens, Laurent; Carnec, Xavier; Lecoin, Manuel Perera; Ramdasi, Rasika; Guivel-Benhassine, Florence; Lew, Erin; Lemke, Greg; Schwartz, Olivier; Amara, Ali

    2012-10-18

    Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine (PtdSer)-dependent phagocytic removal of apoptotic cells, serve as DV entry factors. Cells poorly susceptible to DV are robustly infected after ectopic expression of TIM or TAM receptors. Conversely, DV infection of susceptible cells is inhibited by anti-TIM or anti-TAM antibodies or knockdown of TIM and TAM expression. TIM receptors facilitate DV entry by directly interacting with virion-associated PtdSer. TAM-mediated infection relies on indirect DV recognition, in which the TAM ligand Gas6 acts as a bridging molecule by binding to PtdSer within the virion. This dual mode of virus recognition by TIM and TAM receptors reveals how DVs usurp the apoptotic cell clearance pathway for infectious entry. Copyright © 2012 Elsevier Inc. All rights reserved.

  20. Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndrome.

    Science.gov (United States)

    Roy, Anindita; Roberts, Irene; Vyas, Paresh

    2012-08-01

    Children with Down syndrome (DS) have an increased risk of Acute Myeloid Leukaemia (ML-DS), particularly megakaryoblastic leukaemia, which is clonally -related to the neonatal myeloproliferative syndrome, Transient Abnormal Myelopoiesis (TAM) unique to infants with DS. Molecular, biological, and clinical data indicate that TAM is initiated before birth when fetal liver haematopoietic cells trisomic for chromosome 21 acquire mutations in GATA1. TAM usually resolves spontaneously by 6 months; however 20-30% subsequently develop ML-DS harbouring the same GATA1 mutation(s). This review focuses on recent studies describing haematological, clinical and biological features of TAM and discusses approaches to diagnose, treat and monitor minimal residual disease in TAM. An important unanswered question is whether ML-DS is always preceded by TAM as it may be clinically and possibly haematologically 'silent'. We have briefly discussed the role of population-based screening for TAM and development of treatment strategies to eliminate the preleukaemic TAM clone, thereby preventing ML-DS. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis.

    Science.gov (United States)

    Law, Luke A; Graham, Douglas K; Di Paola, Jorge; Branchford, Brian R

    2018-01-01

    The GAS6/TYRO3-AXL-MERTK (TAM) signaling pathway is essential for full and sustained platelet activation, as well as thrombus stabilization. Inhibition of this pathway decreases platelet aggregation, shape change, clot retraction, aggregate formation under flow conditions, and surface expression of activation markers. Transgenic mice deficient in GAS6, or any of the TAM family of receptors that engage this ligand, exhibit in vivo protection against arterial and venous thrombosis but do not demonstrate either spontaneous or prolonged bleeding compared to their wild-type counterparts. Comparable results are observed in wild-type mice treated with pharmacological inhibitors of the GAS6-TAM pathway. Thus, GAS6/TAM inhibition offers an attractive novel therapeutic option that may allow for a moderate reduction in platelet activation and decreased thrombosis while still permitting the primary hemostatic function of platelet plug formation.

  2. The lack of cross-national equivalence of a therapist adherence measure (TAM-R) in multisystemic therapy (MST)

    NARCIS (Netherlands)

    Lange, A.M.C.; Scholte, R.H.J.; Geffen, W. van; Timman, R.; Busschbach, J.J.V. van; Rijken, R.E.A. van der

    2016-01-01

    This two-study report investigates the equivalence of the Dutch Therapist Adherence Measure Revised (TAM-R) to the US original. The TAM-R is a questionnaire measuring therapist adherence to the treatment model of Multisystemic Therapy (MST). Monitoring of therapist adherence is essential for

  3. The Structure of a Conserved Domain of TamB Reveals a Hydrophobic β Taco Fold.

    Science.gov (United States)

    Josts, Inokentijs; Stubenrauch, Christopher James; Vadlamani, Grishma; Mosbahi, Khedidja; Walker, Daniel; Lithgow, Trevor; Grinter, Rhys

    2017-12-05

    The translocation and assembly module (TAM) plays a role in the transport and insertion of proteins into the bacterial outer membrane. TamB, a component of this system spans the periplasmic space to engage with its partner protein TamA. Despite efforts to characterize the TAM, the structure and mechanism of action of TamB remained enigmatic. Here we present the crystal structure of TamB amino acids 963-1,138. This region represents half of the conserved DUF490 domain, the defining feature of TamB. TamB 963-1138 consists of a concave, taco-shaped β sheet with a hydrophobic interior. This β taco structure is of dimensions capable of accommodating and shielding the hydrophobic side of an amphipathic β strand, potentially allowing TamB to chaperone nascent membrane proteins from the aqueous environment. In addition, sequence analysis suggests that the structure of TamB 963-1138 is shared by a large portion of TamB. This architecture could allow TamB to act as a conduit for membrane proteins. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  4. An Exploratory Study of the Critical Factors Affecting the Acceptability of Automated Teller Machine (ATM) in Nigeria

    OpenAIRE

    Olusegun Folorunso; Oluwafunmilayo Ayobami Ateji; Gabriel Oludare Awe

    2010-01-01

    This paper uses the Technology Acceptance Model (TAM) as a basis for studying critical factors that affects the acceptability of Automated Teller Machine (ATM) in Nigeria. Questionnaire approach was used with the respondents predominantly between 20-29 years old. Factor analysis was used to test which of the factors are the main factors affecting the adoption of the technology in Nigeria. It was discovered that the major factors affecting people’s intention to accept ATM are the security issu...

  5. Does Usability Matter? An Analysis of the Impact of Usability on Technology Acceptance in ERP Settings

    Directory of Open Access Journals (Sweden)

    Brenda M Scholtz

    2016-11-01

    Full Text Available Though the field of management information systems, as a sector and a discipline, is the inventor of many guidelines and models, it appears to be a slow runner on practical implications of interface usability. This usability can influence end users’ attitude and behavior to use IT. The purpose of this paper was to examine the interface usability of a popular Enterprise Resource Planning (ERP software system, SAP, and to identify related issues and implications to the Technology Acceptance Model (TAM. A survey was conducted of 112 SAP ERP users from an organization in the heavy metal industry in Bangladesh. The partial least squares technique was used to analyze the survey data. The survey findings empirically confirmed that interface usability has a significant impact on users’ perceptions of usefulness and ease of use which ultimately affects attitudes and intention to use the ERP software. The research model extends the TAM by incorporating three criteria of interface usability. It is the first known study to investigate usability criteria as an extension of TAM.

  6. Information Communication Technologies in the Classroom: Expanding TAM to Examine Instructor Acceptance and Use

    Science.gov (United States)

    Huntington, Heidi; Worrell, Tracy

    2013-01-01

    Studies show that use of computer-based information communication technologies (ICTs) can have positive impacts on student motivation and learning. The present study examines the issue of ICT adoption in the classroom by expanding the Technology Acceptance Model to identify factors that contribute to teacher acceptance and use of these…

  7. The Gas6/TAM System and Multiple Sclerosis.

    Science.gov (United States)

    Bellan, Mattia; Pirisi, Mario; Sainaghi, Pier Paolo

    2016-10-28

    Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS.

  8. Factors Influencing Acceptance of Electronic Health Records in Hospitals

    OpenAIRE

    Wilkins, Melinda A

    2009-01-01

    The study's aim was to examine factors that may influence health information managers in the adoption of electronic health records. The Technology Acceptance Model (TAM) served as theoretical foundation for this quantitative study. Hospital health information managers in Arkansas were queried as to the constructs of perceived usefulness, perceived ease of use, and behavior intention. The study population comprised 94 health information managers with a return rate of 74.5 percent. One manager ...

  9. Investigating IT Faculty Resistance to Learning Management System Adoption Using Latent Variables in an Acceptance Technology Model.

    Science.gov (United States)

    Bousbahi, Fatiha; Alrazgan, Muna Saleh

    2015-01-01

    To enhance instruction in higher education, many universities in the Middle East have chosen to introduce learning management systems (LMS) to their institutions. However, this new educational technology is not being used at its full potential and faces resistance from faculty members. To investigate this phenomenon, we conducted an empirical research study to uncover factors influencing faculty members' acceptance of LMS. Thus, in the Fall semester of 2014, Information Technology faculty members were surveyed to better understand their perceptions of the incorporation of LMS into their courses. The results showed that personal factors such as motivation, load anxiety, and organizational support play important roles in the perception of the usefulness of LMS among IT faculty members. These findings suggest adding these constructs in order to extend the Technology acceptance model (TAM) for LMS acceptance, which can help stakeholders of the university to implement the use of this system. This may assist in planning and evaluating the use of e-learning.

  10. Clinical application and prognostic assessment of serum Tumor Associated Material (TAM) from esophageal cancer patients.

    Science.gov (United States)

    Zhou, K; Yan, Y; Zhao, S; Li, B

    2014-01-01

    To explore the correlation between serum levels of Tumor Associated Materials (TAM) and clinicopathological parameters and prognosis in patients with esophageal cancer (EC). The levels of TAM were determined by chemical colorimetry in 100 EC patients and 100 healthy controls. Serum TAM levels were significantly higher in patients with esophageal carcinoma than in the control group (p TAM were associated with tumor size (p = 0.004), tumor depth (p TAM (p = 0.001). Kaplan-Meier analysis showed patients with increased levels of TAM after operation had an lower overall survival (p TAM may be an independent factor affecting the overall survival and disease-free survival (p TAM could be used to screen for tumor and assess unfavorable prognosis in patients with EC.

  11. Modelling the Intention to Use Technology for Teaching Mathematics among Pre-Service Teachers in Serbia

    Science.gov (United States)

    Teo, Timothy; Milutinovic, Verica

    2015-01-01

    This study aims to examine the variables that influence Serbian pre-service teachers' intention to use technology to teach mathematics. Using the technology acceptance model (TAM) as the framework, we developed a research model to include subjective norm, knowledge of mathematics, and facilitating conditions as external variables to the TAM. In…

  12. An Empirical Study Of User Acceptance Of Online Social Networks Marketing

    Directory of Open Access Journals (Sweden)

    Olumayowa Mulero

    2013-07-01

    Full Text Available The explosion of Internet usage has drawn the attention of researchers towards online Social Networks Marketing (SNM. Research has shown that a number of the Internet users are distrustful and indecisive, when it comes to the use of social networks marketing system. Therefore, there is a need for researchers to identify some of the factors that determine users’ acceptance of social networks marketing using Technology Acceptance Model (TAM. This study extended the Technology Acceptance Model theoretical framework to predict consumer acceptance of social networks marketing within Western Cape Province of South Africa. The research model was tested using data collected from 470 questionnaires and analysed using linear regression. The results showed that user intentions to use SNM are strongly and positively correlated with user acceptance of using SNM systems. Empirical results confirmed that perceived credibility and perceived usefulness are the strongest determinant in predicting user intentions to use SNM system.

  13. Dynamic Simulation of 1D Cellular Automata in the Active aTAM.

    Science.gov (United States)

    Jonoska, Nataša; Karpenko, Daria; Seki, Shinnosuke

    2015-07-01

    The Active aTAM is a tile based model for self-assembly where tiles are able to transfer signals and change identities according to the signals received. We extend Active aTAM to include deactivation signals and thereby allow detachment of tiles. We show that the model allows a dynamic simulation of cellular automata with assemblies that do not record the entire computational history but only the current updates of the states, and thus provide a way for (a) algorithmic dynamical structural changes in the assembly and (b) reusable space in self-assembly. The simulation is such that at a given location the sequence of tiles that attach and detach corresponds precisely to the sequence of states the synchronous cellular automaton generates at that location.

  14. TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis.

    Science.gov (United States)

    van der Meer, Jonathan H M; van der Poll, Tom; van 't Veer, Cornelis

    2014-04-17

    TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. Also, they affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S. Protein S is more commonly known as an important cofactor for protein C as well as a direct inhibitor of multiple coagulation factors. To our knowledge, the functions of Gas6 are limited to TAM receptor activation. When activated, the TAM receptors have effects on primary hemostasis and coagulation and display an anti-inflammatory or a proinflammatory effect, depending on cell type. To comprehend the effects that the TAM receptors and their ligands have on hemostasis and inflammation, we compare studies that report the different phenotypes displayed by mice with deficiencies in the genes of this receptor family and its ligands (protein S(+/-), Gas6(-/-), TAM(-/-), and variations of these). In this manner, we aim to display which features are attributable to the different ligands. Because of the effects TAM receptors have on hemostasis, inflammation, and cancer growth, their modulation could make interesting therapeutic targets in thromboembolic disease, atherosclerosis, sepsis, autoimmune disease, and cancer.

  15. Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy

    NARCIS (Netherlands)

    Ochodnicky, Peter; Lattenist, Lionel; Ahdi, Mohamed; Kers, Jesper; Uil, Melissa; Claessen, Nike; Leemans, Jaklien C.; Florquin, Sandrine; Meijers, Joost C. M.; Gerdes, Victor E. A.; Roelofs, Joris J. T. H.

    2017-01-01

    TAM receptors (Tyro3, Axl, and Mer) have been implicated in innate immunity. Circulating TAM receptor soluble forms (sTyro3, sAxl, sMer) are related to autoimmune disorders. We investigated TAM and their ligand protein S in patients with diabetes. Urinary and plasma levels of protein S, sTyro3,

  16. User Acceptance of Mobile Technology: A Campus-Wide Implementation of Blackboard's Mobile™ Learn Application

    Science.gov (United States)

    Chen, Baiyun; Sivo, Stephen; Seilhamer, Ryan; Sugar, Amy; Mao, Jin

    2013-01-01

    Mobile learning is a fast growing trend in higher education. This study examined how an extended technology acceptance model (TAM) could evaluate and predict the use of a mobile application in learning. A path analysis design was used to measure the mediating effects on the use of Blackboard's Mobile™ Learn application in coursework (N = 77). The…

  17. Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response.

    Science.gov (United States)

    Davra, Viralkumar; Kimani, Stanley G; Calianese, David; Birge, Raymond B

    2016-11-29

    The TAM family of receptors (i.e., Tyro3, Axl, and Mertk), and their ligands Growth arrest specific factor 6 (Gas6) and Protein S (Pros1) contribute to several oncogenic processes, such as cell survival, invasion, migration, chemo-resistance, and metastasis, whereby expression often correlates with poor clinical outcomes. In recent years, there has been great interest in the study of TAM receptors in cancer, stemming both from their roles as oncogenic signaling receptors, as well as their roles in tumor immunology. As a result, several classes of TAM inhibitors that include small molecule tyrosine kinase inhibitors, monoclonal antibodies, decoy receptors, as well as novel strategies to target TAM ligands are being developed. This paper will review the biology of TAM receptors and their ligands with a focus on cancer, as well as evidence-based data for the continued pursuit of TAM/Gas6 inhibitors in clinical practice.

  18. Barcode Technology Acceptance and Utilization in Health Information Management Department at Academic Hospitals According to Technology Acceptance Model.

    Science.gov (United States)

    Ehteshami, Asghar

    2017-03-01

    Nowdays, due to the increasing importance of quality care, organizations focuse on the improving provision, management and distribution of health. On one hand, incremental costs of the new technologies and on the other hand, increased knowledge of health care recipients and their expectations for high quality services have doubled the need to make changes in order to respond to resource constraints (financial, human, material). For this purpose, several technologies, such as barcode, have been used in hospitals to improve services and staff productivity; but various factors effect on the adoption of new technologies and despite good implementation of a technology and its benefits, sometimes personnel don't accept and don't use it. This is an applied descriptive cross-sectional study in which all the barcode users in health information management department of the three academic hospitals (Feiz, Al-Zahra, Ayatollah Kashani) affiliated to Isfahan University of Medical Sciences were surveyed by the barcode technology acceptance questionnaire, in six areas as following: barcode ease of learning, capabilities, perception of its usefulness and its ease of use, users attitudes towards its using, and users intention. The finding showed that barcode technology total acceptance was relatively desirable (%76.9); the most compliance with TAM model was related to the user perceptions about the ease of use of barcode technology and the least compliance was related to the ease of learning barcode technology (respectively %83.7 and %71.5). Ease of learning and barcode capability effect of usefulness and perceived ease of barcode technology. Users perceptions effect their attitudes toward greater use of technology and their attitudes have an effect on their intention to use the technology and finally, their intention makes actual use of the technology (acceptance). Therefore, considering the six elements related to technology implementation can be important in the barcode

  19. The roles of TAM receptor tyrosine kinases in the mammalian testis and immunoprivileged sites.

    Science.gov (United States)

    Deng, Tingting; Chen, Qiaoyuan; Han, Daishu

    2016-01-01

    Three members of a receptor tyrosine kinase family, including Tyro3, Axl, and Mer, are collectively called as TAM receptors. TAM receptors have two common ligands, namely, growth arrest specific gene 6 (Gas6) and protein S (ProS). The TAM-Gas6/ProS system is essential for phagocytic removal of apoptotic cells, and plays critical roles in regulating immune response. Genetic studies have shown that TAM receptors are essential regulators of the tissue homeostasis in immunoprivileged sites, including the testis, retina and brain. The mechanisms by which the TAM-Gas6/ProS system regulates the tissue homeostasis in immunoprivileged sites are emerging. The roles of the TAM-Gas6/ProS system in regulating the immune privilege were intensively investigated in the mouse testis, and several studies were performed in the eye and brain. This review summarizes our current understanding of TAM signaling in the testis and other immunoprivileged tissues, as well as highlights topics that are worthy of further investigation.

  20. TAM Receptors Are Not Required for Zika Virus Infection in Mice.

    Science.gov (United States)

    Hastings, Andrew K; Yockey, Laura J; Jagger, Brett W; Hwang, Jesse; Uraki, Ryuta; Gaitsch, Hallie F; Parnell, Lindsay A; Cao, Bin; Mysorekar, Indira U; Rothlin, Carla V; Fikrig, Erol; Diamond, Michael S; Iwasaki, Akiko

    2017-04-18

    Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health concern. To investigate the requirement of TAM receptors for ZIKV infection, we used several routes of viral inoculation and compared viral replication in wild-type versus Axl -/- , Mertk -/- , Axl -/- Mertk -/- , and Axl -/- Tyro3 -/- mice in various organs. Pregnant and non-pregnant mice treated with interferon-α-receptor (IFNAR)-blocking (MAR1-5A3) antibody and infected subcutaneously with ZIKV showed no reliance on TAMs for infection. In the absence of IFNAR-blocking antibody, adult female mice challenged intravaginally with ZIKV showed no difference in mucosal viral titers. Similarly, in young mice that were infected with ZIKV intracranially or intraperitoneally, ZIKV replication occurred in the absence of TAM receptors, and no differences in cell tropism were observed. These findings indicate that, in mice, TAM receptors are not required for ZIKV entry and infection. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  1. An Exploratory Study of the Critical Factors Affecting the Acceptability of Automated Teller Machine (ATM in Nigeria

    Directory of Open Access Journals (Sweden)

    Olusegun Folorunso

    2010-01-01

    Full Text Available This paper uses the Technology Acceptance Model (TAM as a basis for studying critical factors that affects the acceptability of Automated Teller Machine (ATM in Nigeria. Questionnaire approach was used with the respondents predominantly between 20-29 years old. Factor analysis was used to test which of the factors are the main factors affecting the adoption of the technology in Nigeria. It was discovered that the major factors affecting people’s intention to accept ATM are the security issues and poor internet connectivity.

  2. Study on Influencing Factor Analysis and Application of Consumer Mobile Commerce Acceptance

    Science.gov (United States)

    Li, Gaoguang; Lv, Tingjie

    Mobile commerce (MC) refers to e-commerce activities carried out using a mobile device such as a phone or PDA. With new technology, MC will be rapidly growing in the near future. At the present time, what factors making consumer accept MC and what MC applications are acceptable by consumers are two of hot issues both for MC providers and f or MC researchers. This study presents a proposed MC acceptance model that integrates perceived playfulness, perceived risk and cost into the TAM to study which factors affect consumer MC acceptance. The proposed model includes five variables, namely perceived risk, cost, perceived usefulness, perceived playfulness, perceived ease of use, perceived playfulness. Then, using analytic hierarchy process (AHP) to calculate weight of criteria involved in proposed model. Finally, the study utilizes fuzzy comprehensive evaluation method to evaluate MC applications accepted possibility, and then a MC application is empirically tested using data collected from a survey of MC consumers.

  3. Esterified dendritic TAM radicals with very high stability and enhanced oxygen sensitivity.

    Science.gov (United States)

    Song, Yuguang; Liu, Yangping; Hemann, Craig; Villamena, Frederick A; Zweier, Jay L

    2013-02-15

    In this work, we have developed a new class of dendritic TAM radicals (TG, TdG, and dTdG) through a convergent method based on the TAM core CT-03 or its deuterated analogue dCT-03 and trifurcated Newkome-type monomer. Among these radicals, dTdG exhibits the best EPR properties with sharpest EPR singlet and highest O(2) sensitivity due to deuteration of both the ester linker groups and the TAM core CT-03. Like the previous dendritic TAM radicals, these new compounds also show extremely high stability toward various reactive species owing to the dendritic encapsulation. The highly charged nature of these molecules resulting from nine carboxylate groups prevents concentration-dependent EPR line broadening at physiological pH. Furthermore, we demonstrate that these TAM radicals can be easily derivatized (e.g., PEGylation) at the nine carboxylate groups and the resulting PEGylated analogue dTdG-PEG completely inhibits the albumin binding, thereby enhancing suitability for in vivo applications. These new dendritic TAM radicals show great potential for in vivo EPR oximetric applications and provide insights on approaches to develop improved and targeted EPR oximetric probes for biomedical applications.

  4. Functional analysis of TamA, a coactivator of nitrogen-regulated gene expression in Aspergillus nidulans.

    Science.gov (United States)

    Small, A J; Todd, R B; Zanker, M C; Delimitrou, S; Hynes, M J; Davis, M A

    2001-06-01

    The tam A gene of Aspergillus nidulans encodes a 739-amino acid protein with similarity to Uga35p/Dal81p/DurLp of Saccharomyces cerevisiae. It has been proposed that TamA functions as a co-activator of AreA, the major nitrogen regulatory protein in A. nidulans. Because AreA functions as a transcriptional activator under nitrogen-limiting conditions, we investigated whether TamA was also present in the nucleus. We found that a GFP-TamA fusion protein was predominantly localised to the nucleus in the presence and absence of ammonium, and that AreA was not required for this distribution. As the predicted DNA-binding domain of TamA is not essential for function, we have used a number of approaches to further define functionally important regions. We have cloned the tamA gene of A. oryzae and compared its functional and sequence characteristics with those of A. nidulans tamA and S. cerevisiae UGA35/DAL81/DURL. The Aspergillus homologues are highly conserved and functionally interchangeable, whereas the S. cerevisiae gene does not complement a tamA mutant when expressed in A. nidulans. Uga35p/Dal81p/DurLp was also found to be unable to recruit AreA. The sequence changes in a number of tamA mutant alleles were determined, and altered versions of TamA were tested for tamA complementation and interaction with AreA. Changes in most regions of TamA appeared to destroy its function, suggesting that the overall conformation of the protein may be critical for its activity.

  5. Acceptance of Swedish e-health services

    Science.gov (United States)

    Jung, Mary-Louise; Loria, Karla

    2010-01-01

    Objective: To investigate older people’s acceptance of e-health services, in order to identify determinants of, and barriers to, their intention to use e-health. Method: Based on one of the best-established models of technology acceptance, Technology Acceptance Model (TAM), in-depth exploratory interviews with twelve individuals over 45 years of age and of varying backgrounds are conducted. Results: This investigation could find support for the importance of usefulness and perceived ease of use of the e-health service offered as the main determinants of people’s intention to use the service. Additional factors critical to the acceptance of e-health are identified, such as the importance of the compatibility of the services with citizens’ needs and trust in the service provider. Most interviewees expressed positive attitudes towards using e-health and find these services useful, convenient, and easy to use. Conclusion: E-health services are perceived as a good complement to traditional health care service delivery, even among older people. These people, however, need to become aware of the e-health alternatives that are offered to them and the benefits they provide. PMID:21289860

  6. Possibilities for Using TAM and Technology Frames Models to Assess the Acceptance of New Technologies in the Chilean Higher Education Quality Assurance

    Directory of Open Access Journals (Sweden)

    Luis González-Bravo

    2015-05-01

    Full Text Available This essay reviews the importance of assessing the degree of acceptance of new technologies in the Chilean higher education institutions, as an input for managing quality assurance. Technology Acceptance and Technology Frames models are described, emphasizing their benefits in this field. Understanding and facilitating the process of new technologies acceptance in the organizations, by identifying those elements which hinder it, allows improving the implementation of quality assurance mechanisms in order to make the educational process more efficient and effective.

  7. Cytoplasmic PELP1 and ERRgamma protect human mammary epithelial cells from Tam-induced cell death.

    Science.gov (United States)

    Girard, Brian J; Regan Anderson, Tarah M; Welch, Siya Lem; Nicely, Julie; Seewaldt, Victoria L; Ostrander, Julie H

    2015-01-01

    Tamoxifen (Tam) is the only FDA-approved chemoprevention agent for pre-menopausal women at high risk for developing breast cancer. While Tam reduces a woman's risk of developing estrogen receptor positive (ER+) breast cancer, the molecular mechanisms associated with risk reduction are poorly understood. Prior studies have shown that cytoplasmic proline, glutamic acid and leucine rich protein 1 (PELP1) promotes Tam resistance in breast cancer cell lines. Herein, we tested for PELP1 localization in breast epithelial cells from women at high risk for developing breast cancer and found that PELP1 was localized to the cytoplasm in 36% of samples. In vitro, immortalized HMECs expressing a nuclear localization signal (NLS) mutant of PELP1 (PELP1-cyto) were resistant to Tam-induced death. Furthermore, PELP1-cyto signaling through estrogen-related receptor gamma (ERRγ) promoted cell survival in the presence of Tam. Overexpression of ERRγ in immortalized HMECs protected cells from Tam-induced death, while knockdown of ERRγ sensitized PELP1-cyto expressing HMECs to Tam. Moreover, Tam-induced HMEC cell death was independent of apoptosis and involved accumulation of the autophagy marker LC3-II. Expression of PELP1-cyto and ERRγ reduced Tam-induced LC3-II accumulation, and knockdown of ERRγ increased LC3-II levels in response to Tam. Additionally, PELP1-cyto expression led to the upregulation of MMP-3 and MAOB, known PELP1 and ERRγ target genes, respectively. Our data indicate that cytoplasmic PELP1 induces signaling pathways that converge on ERRγ to promote cell survival in the presence of Tam. These data suggest that PELP1 localization and/or ERRγ activation could be developed as tissue biomarkers for Tam responsiveness.

  8. Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase.

    Science.gov (United States)

    Kimani, Stanley G; Kumar, Sushil; Davra, Viralkumar; Chang, Yun-Juan; Kasikara, Canan; Geng, Ke; Tsou, Wen-I; Wang, Shenyan; Hoque, Mainul; Boháč, Andrej; Lewis-Antes, Anita; De Lorenzo, Mariana S; Kotenko, Sergei V; Birge, Raymond B

    2016-09-06

    Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigenesis. In the present study, we engineered EGFR/TAM chimeric receptors (EGFR/Tyro3, EGFR/Axl, and EGF/Mertk) with the goals to interrogate post-receptor functions of TAMs, and query whether TAMs have unique or overlapping post-receptor activation profiles. Stable expression of EGFR/TAMs in EGFR-deficient CHO cells afforded robust EGF inducible TAM receptor phosphorylation and activation of downstream signaling. Using a series of unbiased screening approaches, that include kinome-view analysis, phosphor-arrays, RNAseq/GSEA analysis, as well as cell biological and in vivo readouts, we provide evidence that each TAM has unique post-receptor signaling platforms and identify an intrinsic role for Axl that impinges on cell motility and invasion compared to Tyro3 and Mertk. These studies demonstrate that TAM show unique post-receptor signatures that impinge on distinct gene expression profiles and tumorigenic outcomes.

  9. An Analysis of ODL Student Perception and Adoption Behavior using the Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Khor Ean Teng

    2014-12-01

    Full Text Available This paper presents an empirical study aiming on investigating ODL students’ perception and adoption of SCORM Compliant Learning Object (SCLO. With the increasing use of SCLO in recent years, a better understanding and implementation of effective instructional resources is necessary to meet the diverse needs of ODL students and enhance their learning performance. The eventual usage of relevant stakeholders determines the success of a system. The system is useless if it is not used in the expected way by the potential users even though it is a good system. Therefore, the aim of this research is to examine if ODL students will eventually use SCLO for their learning. The study used TAM as a basis to investigate the relationship of external and internal variables. A survey instrument eliciting responses on a series of Likert-type questions was given to selected ODL undergraduate students. The results of this study confirm that users’ perception has significant effect on the acceptance and adoption of SCLO. The study provides a better understanding of students’ behavior on SCLO and the acceptance model.

  10. Understanding Consumer’s Acceptance of Technology-Based Innovations in Retailing

    Directory of Open Access Journals (Sweden)

    Eleonora Pantano

    2012-12-01

    Full Text Available The availability of a huge number of studies about the Technology Acceptance Model (TAM for predicting consumer’s acceptance and usage of innovations in points of sale motivates writing of the present. Review, with emphasis on the new variables integrated in the traditional model. This is concerned with a synthesis of the current progresses in the field, thus offering a unified view of consumers’ behaviour towards new technical solutions. Such  synthesis is achieved from an extensive literature analysis, including computer science, innovation, human-computer interaction, and technology management perspectives. For each case, both opportunities and issues are outlined in order to advance the current knowledge and highlight what practitioners and scholars should take into account for developing new and efficient corporate strategies.

  11. Antecedents of Behavioral Intention to Use Mobile Telecommunication Services: Effects of Corporate Social Responsibility and Technology Acceptance

    Directory of Open Access Journals (Sweden)

    Sanghoon Lee

    2015-08-01

    Full Text Available The concepts of corporate social responsibility (CSR and user experience have been identified as core determinants of the success of service providers. Accordingly, practitioners and researchers have investigated the effects of service providers’ CSR and user experience on behavioral intention to use a particular service. Based on the importance of these concepts, the current study integrates subjective dimensions of CSR with the technology acceptance model (TAM to explore whether the CSR efforts of mobile telecommunication services providers and the service acceptance of their customers have significant effects on behavioral intention to use a service. We apply structural equation modeling and find that two factors from the TAM (i.e., usefulness and ease of use as well as economic, social, and environmental responsibility are significantly related to customer attitude and satisfaction. Moreover, our results show that there are significantly positive relationships between customer attitude and behavioral intention to use a service, as well as between customer satisfaction and intention. Practical and theoretical implications along with notable limitations of the current study are presented.

  12. Targeting Gas6/TAM in cancer cells and tumor microenvironment.

    Science.gov (United States)

    Wu, Guiling; Ma, Zhiqiang; Cheng, Yicheng; Hu, Wei; Deng, Chao; Jiang, Shuai; Li, Tian; Chen, Fulin; Yang, Yang

    2018-01-31

    Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM). In recent years, the roles of Gas6/TAM signalling in cancer cells and the tumour microenvironment have been studied, and some progress has made in targeted therapy, providing new potential directions for future investigations of cancer treatment. In this review, we introduce the Gas6 and TAM receptors and describe their involvement in different cancers and discuss the roles of Gas6 in cancer cells, the tumour microenvironment and metastasis. Finally, we introduce recent studies on Gas6/TAM targeting in cancer therapy, which will assist in the experimental design of future analyses and increase the potential use of Gas6 as a therapeutic target for cancer.

  13. The Concept Framework of Structural Equation model of Mobile Cloud Learning Acceptance for Higher Education Students in the 21st Century

    Directory of Open Access Journals (Sweden)

    Thanyatorn Amornkitpinyo

    2017-08-01

    Full Text Available This research’s part is in the structural equation model of mobile cloud learning acceptance for higher education students in the 21st century as its objective is to synthesize and design the framework of this model. The methods of this research are divided into 2 parts which are synthesis, combining it to process the mode and designing framework concept. The findings of this research are as the following: 1. Basic digital literacy, Information Quality and Social Cloud are included in the model as the exogenous latent variables. 2. Satisfaction and TAM model (perceived usefulness and perceived ease of use are included as the mediating latent variables. 3. Actual Use is the outcome of the model’s latent variable.

  14. TAM receptors support neural stem cell survival, proliferation and neuronal differentiation.

    Science.gov (United States)

    Ji, Rui; Meng, Lingbin; Jiang, Xin; Cvm, Naresh Kumar; Ding, Jixiang; Li, Qiutang; Lu, Qingxian

    2014-01-01

    Tyro3, Axl and Mertk (TAM) receptor tyrosine kinases play multiple functional roles by either providing intrinsic trophic support for cell growth or regulating the expression of target genes that are important in the homeostatic regulation of immune responses. TAM receptors have been shown to regulate adult hippocampal neurogenesis by negatively regulation of glial cell activation in central nervous system (CNS). In the present study, we further demonstrated that all three TAM receptors were expressed by cultured primary neural stem cells (NSCs) and played a direct growth trophic role in NSCs proliferation, neuronal differentiation and survival. The cultured primary NSCs lacking TAM receptors exhibited slower growth, reduced proliferation and increased apoptosis as shown by decreased BrdU incorporation and increased TUNEL labeling, than those from the WT NSCs. In addition, the neuronal differentiation and maturation of the mutant NSCs were impeded, as characterized by less neuronal differentiation (β-tubulin III+) and neurite outgrowth than their WT counterparts. To elucidate the underlying mechanism that the TAM receptors play on the differentiating NSCs, we examined the expression profile of neurotrophins and their receptors by real-time qPCR on the total RNAs from hippocampus and primary NSCs; and found that the TKO NSC showed a significant reduction in the expression of both nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), but accompanied by compensational increases in the expression of the TrkA, TrkB, TrkC and p75 receptors. These results suggest that TAM receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the NGF.

  15. Exploring Students’ Intention to Use LINE for Academic Purposes Based on Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Willard Van De Bogart

    2015-06-01

    Full Text Available The LINE application is often conceived as purely social space; however, the authors of this paper wanted to determine if it could be used for academic purposes. In this study, we examined how undergraduate students accepted LINE in terms of using it for classroom-related activities (e.g., submit homework, follow up course information queries, download materials and explored the factors that might affect their intention to use it. Data were collected from 144 undergraduate students enrolled in an English course that utilized some activities based on LINE app using a questionnaire developed from TAM. Data were analyzed to see if relationships existed among factors when LINE was used to organize classroom experiences. The findings revealed that perceived usefulness and attitude toward usage had positive relationships with intention to use while perceived ease of use was positively related to perceived usefulness. In contrast with TAM assertions, this study did not find any relationship between perceived ease of use and attitude toward usage. Also, the number of social networking sites that students are using had no relationship with intention to use. The study also suggested some kinds of LINE-based learning activities preferred by students, which would be proposed for future courses. This study revealed several useful implications that TAM can be employed as a useful theoretical framework to predict and understand users’ intention to use new technologies in education.

  16. Development of a new monitor for tritium in air model TAM-II

    International Nuclear Information System (INIS)

    Wu Bin; Yang Hailan; Wen Xuelian; Zhao Yi; Yang Huaiyuan

    2001-01-01

    The author introduces development of a real-time continuous tritium monitor model TAM-II. The detector of the instrument is comprised of four geometric-symmetry open wall ionization chamber with the effective volume of 2 L, which enables to minimize the remember effect of the ionization chamber due to contamination by the monitored tritium. It is γ background compensation rate is better than 97% in almost all direction. The detector is equipped with a FET static electrometer working in micro-current integration mode. The measurement process of the tritium monitor can be controlled automatically by a micro-processor sheet, such as automatic range changing, data displaying and storing, and data processing. The measuring range is 6 - 10 6 Bq/L. It is especially application for monitoring tritium in off-gas effluence from glove-box or stack of tritium facility and laboratory

  17. Causal Relationship Model of the Information and Communication Technology Skill Affect the Technology Acceptance Process in the 21ST Century for Undergraduate Students

    Directory of Open Access Journals (Sweden)

    Thanyatorn Amornkitpinyo

    2015-02-01

    Full Text Available The objective of this study is to design a framework for a causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process (TAP for undergraduate students in the 21ST Century. This research uses correlational analysis. A consideration of the research methodology is divided into two sections. The first section involves a synthesis concept framework for process acceptance of the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century. The second section proposes the design concept framework of the model. The research findings are as follows: 1 The exogenous latent variables included in the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century are basic ICT skills and self-efficacy. 2 The mediating latent variables of the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century are from the TAM Model, these includes three components: 1 perceived usefulness, 2 perceived ease of use and 3 attitudes. 3 The outcome latent variable of the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century is behavioural intention.

  18. Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.

    Science.gov (United States)

    Bhattacharyya, Suchita; Zagórska, Anna; Lew, Erin D; Shrestha, Bimmi; Rothlin, Carla V; Naughton, John; Diamond, Michael S; Lemke, Greg; Young, John A T

    2013-08-14

    Upon activation by the ligands Gas6 and Protein S, Tyro3/Axl/Mer (TAM) receptor tyrosine kinases promote phagocytic clearance of apoptotic cells and downregulate immune responses initiated by Toll-like receptors and type I interferons (IFNs). Many enveloped viruses display the phospholipid phosphatidylserine on their membranes, through which they bind Gas6 and Protein S and engage TAM receptors. We find that ligand-coated viruses activate TAM receptors on dendritic cells (DCs), dampen type I IFN signaling, and thereby evade host immunity and promote infection. Upon virus challenge, TAM-deficient DCs display type I IFN responses that are elevated in comparison to wild-type cells. As a consequence, TAM-deficient DCs are relatively resistant to infection by flaviviruses and pseudotyped retroviruses, but infection can be restored with neutralizing type I IFN antibodies. Correspondingly, a TAM kinase inhibitor antagonizes the infection of wild-type DCs. Thus, TAM receptors are engaged by viruses in order to attenuate type I IFN signaling and represent potential therapeutic targets. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. University staff adoption of iPads: An empirical study using an extended TAM model

    Directory of Open Access Journals (Sweden)

    Michael Steven Lane

    2014-11-01

    Full Text Available This research examined key factors influencing adoption of iPads by university staff. An online survey collected quantitative data to test hypothesised relationships in an extended TAM model. The findings show that university staff consider iPads easy to use and useful, with a high level of compatibility with their work. Social status had no influence on their attitude to using an iPad. However older university staff and university staff with no previous experience in using a similar technology such as an iPhone or smartphone found iPads less easy to use. Furthermore, a lack of formal end user ICT support impacted negatively on the use of iPads.

  20. Studi Mengenai Peneriamaan system ERP: EnhancementTerhadap Model Penerimaan Sistem ERP Berbasis Technoloy Acceptance Model

    OpenAIRE

    Govindaraju, Rajesri; de Bruijn, E.J.; Govindaraju, R.; Indriany, Nenny

    2007-01-01

    Dalam penelitian dibangun model yang menjelaskan penerimaan user terhadap sistem ERP yang diimplementasikan, serta melakukan survey untuk menguji hipotesis. Dengan model yang dibangun dikaji pengaruh attitude toward ERP system use dan ERP symbolic adoption yang mengacu pada penerimaan mental secara sukarela terhadap sistem ERP. Model yang digunakan dalam penelitian ini adalah adaptasi dari model TAM yang dikembangkan oleh Nah et al (2004) dan menambahkan lima konstruk baru yang berkaitan deng...

  1. Structural elucidation of the DFG-Asp in and DFG-Asp out states of TAM kinases and insight into the selectivity of their inhibitors.

    Science.gov (United States)

    Messoussi, Abdellah; Peyronnet, Lucile; Feneyrolles, Clémence; Chevé, Gwénaël; Bougrin, Khalid; Yasri, Aziz

    2014-10-10

    Structural elucidation of the active (DFG-Asp in) and inactive (DFG-Asp out) states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the three TAM members Tyro-3, Axl and Mer. DFG-Asp in and DFG-Asp out homology models of each one were built based on the X-ray structure of c-Met kinase, an enzyme with a closely related sequence. Structural validation and in silico screening enabled identification of critical amino acids for ligand binding within the active site of each DFG-Asp in and DFG-Asp out model. The position and nature of amino acids that differ among Tyro-3, Axl and Mer, and the potential role of these residues in the design of selective TAM ligands, are discussed.

  2. Subcellular compartmentalization of Cd and Zn in two bivalves. II. Significance of trophically available metal (TAM)

    Science.gov (United States)

    Wallace, W.G.; Luoma, S.N.

    2003-01-01

    This paper examines how the subcellular partitioning of Cd and Zn in the bivalves Macoma balthica and Potamocorbula amurensis may affect the trophic transfer of metal to predators. Results show that the partitioning of metals to organelles, 'enzymes' and metallothioneins (MT) comprise a subcellular compartment containing trophically available metal (TAM; i.e. metal trophically available to predators), and that because this partitioning varies with species, animal size and metal, TAM is similarly influenced. Clams from San Francisco Bay, California, were exposed for 14 d to 3.5 ??g 1-1 Cd and 20.5 ??g 1-1 Zn, including 109Cd and 65Zn as radiotracers, and were used in feeding experiments with grass shrimp Palaemon macrodatylus, or used to investigate the subcellular partitioning of metal. Grass shrimp fed Cd-contaminated P. amurensis absorbed ???60% of ingested Cd, which was in accordance with the partitioning of Cd to the bivalve's TAM compartment (i.e. Cd associated with organelles, 'enzymes' and MT); a similar relationship was found in previous studies with grass shrimp fed Cd-contaminated oligochaetes. Thus, TAM may be used as a tool to predict the trophic transfer of at least Cd. Subcellular fractionation revealed that ???34% of both the Cd and Zn accumulated by M. balthica was associated with TAM, while partitioning to TAM in P. amurensis was metal-dependent (???60% for TAM-Cd%, ???73% for TAM-Zn%). The greater TAM-Cd% of P. amurensis than M. balthica is due to preferential binding of Cd to MT and 'enzymes', while enhanced TAM-Zn% of P. amurensis results from a greater binding of Zn to organelles. TAM for most species-metal combinations was size-dependent, decreasing with increased clam size. Based on field data, it is estimated that of the 2 bivalves, P. amurensis poses the greater threat of Cd exposure to predators because of higher tissue concentrations and greater partitioning as TAM; exposure of Zn to predators would be similar between these species.

  3. Evaluation Study of the Tactical Atmospheric Modeling System/Real-Time (TAMS-RT) at NPMOC San Diego

    National Research Council Canada - National Science Library

    Reiss, Arthur

    1999-01-01

    ...) has been developed by the Naval Research Lab in Monterey, California to meet this task. A forecast system employing COAMPS, called the Tactical Atmospheric Mesoscale System- Real Time (TAMS-RT...

  4. The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy.

    Science.gov (United States)

    Paolino, Magdalena; Penninger, Josef M

    2016-10-21

    The TAM receptor protein tyrosine kinases-Tyro3, Axl, and Mer-are essential regulators of immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) and Protein S (Pros1), these receptors ensure the resolution of inflammation by dampening the activation of innate cells as well as by restoring tissue function through promotion of tissue repair and clearance of apoptotic cells. Their central role as negative immune regulators is highlighted by the fact that deregulation of TAM signaling has been linked to the pathogenesis of autoimmune, inflammatory, and infectious diseases. Importantly, TAM receptors have also been associated with cancer development and progression. In a cancer setting, TAM receptors have a dual regulatory role, controlling the initiation and progression of tumor development and, at the same time, the associated anti-tumor responses of diverse immune cells. Thus, modulation of TAM receptors has emerged as a potential novel strategy for cancer treatment. In this review, we discuss our current understanding of how TAM receptors control immunity, with a particular focus on the regulation of anti-tumor responses and its implications for cancer immunotherapy.

  5. An Examination of Individual’s Perceived Security and Privacy of the Internet in Malaysia and the Influence of This on Their Intention to Use E-Commerce: Using An Extension of the Technology Acceptance Model

    OpenAIRE

    Muniruddeen Lallmahamood

    2007-01-01

    This study explores the impact of perceived security and privacy on the intention to use Internet banking. An extended version of the technology acceptance model (TAM) is used to examine the above perception. A survey was distributed, the 187 responses mainly from the urban cities in Malaysia, hav e generally agreed that security and privacy are still the main concerns while using Internet banking. The research model explains over half of the variance of the intenti...

  6. IL6 induces TAM resistance via kinase-specific phosphorylation of ERα in OVCA cells.

    Science.gov (United States)

    Wang, Yue; Niu, Xiu Long; Guo, Xiao Qin; Yang, Jing; Li, Ling; Qu, Ye; Xiu Hu, Cun; Mao, Li Qun; Wang, Dan

    2015-06-01

    About 40-60% of ovarian cancer (OVCA) cases express ERα, but only a small proportion of patients respond clinically to anti-estrogen treatment with estrogen receptor (ER) antagonist tamoxifen (TAM). The mechanism of TAM resistance in the course of OVCA progression remains unclear. However, IL6 plays a critical role in the development and progression of OVCA. Our recent results indicated that IL6 secreted by OVCA cells may promote the resistance of these cells to TAM via ER isoforms and steroid hormone receptor coactivator-1. Here we demonstrate that both exogenous (a relatively short period of treatment with recombinant IL6) and endogenous IL6 (generated as a result of transfection with a plasmid encoding sense IL6) increases expression of pERα-Ser118 and pERα-Ser167 in non-IL6-expressing A2780 cells, while deleting endogenous IL6 expression in IL6-overexpressing CAOV-3 cells (by transfection with a plasmid encoding antisense IL6) reduces expression of pERα-Ser118 and pERα-Ser167, indicating that IL6-induced TAM resistance may also be associated with increased expression of pERα-Ser118 and pERα-Ser167 in OVCA cells. Results of further investigation indicate that IL6 phosphorylates ERα at Ser118 and Ser167 by triggering activation of MEK/ERK and phosphotidylinositol 3 kinase/Akt signaling, respectively, to activate the ER pathway and thereby induce OVCA cells resistance to TAM. These results indicate that IL6 secreted by OVCA cells may also contribute to the refractoriness of these cells to TAM via the crosstalk between ER and IL6-mediated intracellular signal transduction cascades. Overexpression of IL6 not only plays an important role in OVCA progression but also promotes TAM resistance. Our results indicate that TAM-IL6-targeted adjunctive therapy may lead to a more effective intervention than TAM alone. © 2015 Society for Endocrinology.

  7. Structural Elucidation of the DFG-Asp in and DFG-Asp out States of TAM Kinases and Insight into the Selectivity of Their Inhibitors

    Directory of Open Access Journals (Sweden)

    Abdellah Messoussi

    2014-10-01

    Full Text Available Structural elucidation of the active (DFG-Asp in and inactive (DFG-Asp out states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the three TAM members Tyro-3, Axl and Mer. DFG-Asp in and DFG-Asp out homology models of each one were built based on the X-ray structure of c-Met kinase, an enzyme with a closely related sequence. Structural validation and in silico screening enabled identification of critical amino acids for ligand binding within the active site of each DFG-Asp in and DFG-Asp out model. The position and nature of amino acids that differ among Tyro-3, Axl and Mer, and the potential role of these residues in the design of selective TAM ligands, are discussed.

  8. Molecular insights of Gas6/TAM in cancer development and therapy.

    Science.gov (United States)

    Wu, Guiling; Ma, Zhiqiang; Hu, Wei; Wang, Dongjin; Gong, Bing; Fan, Chongxi; Jiang, Shuai; Li, Tian; Gao, Jianyuan; Yang, Yang

    2017-03-23

    Since growth arrest-specific gene 6 (Gas6) was discovered in 1988, numerous studies have highlighted the role of the Gas6 protein and its receptors Tyro3, Axl and Mer (collectively referred to as TAM), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic leukaemia (AML) is a Gas6-dependent cancer, and Gas6 expression predicts poor prognosis in AML. Interestingly, Gas6 also has a role in establishing tumour dormancy in the bone marrow microenvironment and in suppressing intestinal tumorigenesis. Numerous studies regarding cancer therapy have targeted Gas6 and TAM receptors with good results. However, some findings have suggested that Gas6 is associated with the development of resistance to cancer therapies. Concerning these significant effects of Gas6 in numerous cancers, we discuss the roles of Gas6 in cancer development in this review. First, we introduce basic knowledge on Gas6 and TAM receptors. Next, we describe and discuss the involvement of Gas6 and TAM receptors in cancers from different organ systems. Finally, we highlight the progress in therapies targeting Gas6 and TAM receptors. This review presents the significant roles of Gas6 in cancers from different systems and may contribute to the continued promotion of Gas6 as a therapeutic target.

  9. TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

    NARCIS (Netherlands)

    van der Meer, Jonathan H. M.; van der Poll, Tom; van 't Veer, Cornelis

    2014-01-01

    TAM receptors (Tyro3, Axl, andMer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. Also, they affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein

  10. Measuring the moderating influence of gender on the acceptance of e-book amongst mathematics and statistics students at universities in Libya

    Directory of Open Access Journals (Sweden)

    Asma Mohmead Smeda

    2017-06-01

    Full Text Available The success of using any types of technology in education depends on a large extent of the acceptance of information technology (IT by students. Therefore, understanding the factors influencing the acceptance of electronic book (e-book is essential for decision-makers and those interested in the e-book industry. Based on an extended technology acceptance model (TAM, this paper examines the impact of some factors on the students’ behavioural intention (BI toward adoption of the e-book in mathematics and statistics. This paper also investigates the effect of gender differences on the relationship between the factors affecting the acceptance of e-book. A self-administered survey was used to collect data from 392 mathematics and statistics undergraduate students. The research model has shown that the factors related to the social factor and users’ characteristics are the critical factors that affect the acceptance of the e-book. The results also indicated that perceived usefulness (PU, perceived ease of use (PEOU and students’ attitude (AU have strongly affected students’ BI. Self-efficacy (SE has a significant impact on PEOU while social influence (SI has a significant influence on students’ AU. Moreover, the results confirmed that most of the TAM constructs were significant in both models (males and females, where there are no differences between males and females; however, only PEOU has been affected by the gender moderator. The results showed that the impact of the factor of SI on females was more than males. On the other hand, female students were more confident in the use of the e-book than males. In general, the female students’ model was more powerful in explaining the variance than males’ model.

  11. Exploring Lecturers' Perceptions of Learning Management System: An Empirical Study Based on TAM

    Directory of Open Access Journals (Sweden)

    Wei Wei Goh

    2014-06-01

    Full Text Available With the pervasive take-up and presence of digital technologies, learning management system (LMS is popular for its open accessibility and its interactive nature. Implementation of LMS has become part of the strategic plan in higher education institution to enhance the flexibility in teaching and learning. It is essential to explore the perceptions of users in using the LMS in order to inform stakeholders the positive influencing aspects and improve the negative factors in the future. This study investigates the perception of lecturers in using LMS in term of perceived usefulness and perceived ease of use for teaching purposes. Technology Acceptance Model (TAM is used as the research framework to design the questionnaire. An online questionnaire was created to address the research questions. The results reveal that lecturers do not react positively towards perceived ease of use of Moodle for teaching. Lecturers treat Moodle as content repository and do not fully utilize the interactive features in Moodle. It was found that usability issues, interaction and communication issues had a negative impact on the lecturers' perception.

  12. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation.

    Science.gov (United States)

    Ji, Rui; Tian, Shifu; Lu, Helen J; Lu, Qingjun; Zheng, Yan; Wang, Xiaomin; Ding, Jixiang; Li, Qiutang; Lu, Qingxian

    2013-12-15

    TAM tyrosine kinases play multiple functional roles, including regulation of the target genes important in homeostatic regulation of cytokine receptors or TLR-mediated signal transduction pathways. In this study, we show that TAM receptors affect adult hippocampal neurogenesis and loss of TAM receptors impairs hippocampal neurogenesis, largely attributed to exaggerated inflammatory responses by microglia characterized by increased MAPK and NF-κB activation and elevated production of proinflammatory cytokines that are detrimental to neuron stem cell proliferation and neuronal differentiation. Injection of LPS causes even more severe inhibition of BrdU incorporation in the Tyro3(-/-)Axl(-/-)Mertk(-/-) triple-knockout (TKO) brains, consistent with the LPS-elicited enhanced expression of proinflammatory mediators, for example, IL-1β, IL-6, TNF-α, and inducible NO synthase, and this effect is antagonized by coinjection of the anti-inflammatory drug indomethacin in wild-type but not TKO brains. Conditioned medium from TKO microglia cultures inhibits neuron stem cell proliferation and neuronal differentiation. IL-6 knockout in Axl(-/-)Mertk(-/-) double-knockout mice overcomes the inflammatory inhibition of neurogenesis, suggesting that IL-6 is a major downstream neurotoxic mediator under homeostatic regulation by TAM receptors in microglia. Additionally, autonomous trophic function of the TAM receptors on the proliferating neuronal progenitors may also promote progenitor differentiation into immature neurons.

  13. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.

    Science.gov (United States)

    Miner, Jonathan J; Daniels, Brian P; Shrestha, Bimmi; Proenca-Modena, Jose L; Lew, Erin D; Lazear, Helen M; Gorman, Matthew J; Lemke, Greg; Klein, Robyn S; Diamond, Michael S

    2015-12-01

    The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer leaflet of their membranes, enabling TAM receptor activation and downregulation of antiviral responses. Accordingly, we hypothesized that a deficiency of TAM receptors would enhance antiviral responses and protect against viral infection. Unexpectedly, mice lacking Mertk and/or Axl, but not Tyro3, exhibited greater vulnerability to infection with neuroinvasive West Nile and La Crosse encephalitis viruses. This phenotype was associated with increased blood-brain barrier permeability, which enhanced virus entry into and infection of the brain. Activation of Mertk synergized with interferon-β to tighten cell junctions and prevent virus transit across brain microvascular endothelial cells. Because TAM receptors restrict pathogenesis of neuroinvasive viruses, these findings have implications for TAM antagonists that are currently in clinical development.

  14. Acceptance of Health Information Technologies, Acceptance of Mobile Health: A Review Article.

    Science.gov (United States)

    Garavand, A; Samadbeik, M; Kafashi, M; Abhari, Sh

    2017-12-01

    Mobile health is one of the new technologies for the utilization of health information. For its successful implementation as well as any other system, we must primarily measure the adoption and use of its factors. The purpose of this study was to systematically investigate published articles about the factors affecting the adoption of mobile health and categorizing the factors affecting the adoption of this system. This study is a comprehensive review done by searching major databases such as Google Scholar, Emerald, Science Direct, Iran Medex, SID, Magiran, Pub med, etc. In addition, we use Mobile, mobile Health + adoption, mobile Health + TAM, Health + TAM keywords in the range of 2004 to 2015. Among the studies that use information technology theories to survey the factors affecting the adoption of mobile health, TAM model was used more than other models. Factors such as perceived ease of use, perceived usefulness and facilitating condition form TUATU are the most effective in the adoption of mobile health. Results showed that by considering factors such as perceived ease of use, perceived usefulness and facilitating condition can increase the adoption of mobile health system. Consequently, these factors are recommended to be considered in planning to run systems.

  15. INFORMATION SYSTEM QUALITY INFLUENCE ON ORGANIZATION PERFORMANCE: A MODIFICATION OF TECHNOLOGY-BASED INFORMATION SYSTEM ACCEPTANCE AND SUCCESS MODEL

    Directory of Open Access Journals (Sweden)

    Trisnawati N.

    2017-12-01

    Full Text Available This study aims to examine the effect of information system quality on technology-based accounting information systems usage and their impact on organizational performance on local government. This study is based on Technology Acceptance Model (TAM, IS Success Model, and the success of technology-based information systems. This study is a combination of previous studies conducted by Seddon and Kiew (1997, Saeed and Helm (2008, and DeLone and McLean (1992. This study used survey method and took 101 respondents from accounting staff working in Malang and Mojokerto regencies. This study uses Partial Least Square to examine research data. Research result exhibits information system qualities affecting benefit perception and user satisfaction. Technology-based accounting information systems usage in local government is influenced by benefits perception and user satisfaction. Research result concluded that technology-based accounting information systems usage will affect the performance of local government organizations.

  16. Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis.

    Science.gov (United States)

    Espindola, Milena S; Habiel, David M; Narayanan, Rohan; Jones, Isabelle; Coelho, Ana L; Murray, Lynne A; Jiang, Dianhua; Noble, Paul W; Hogaboam, Cory M

    2018-06-01

    Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling, which progressively abolishes lung function in an RTK (receptor tyrosine kinase)-dependent manner. Gas6 (growth arrest-specific 6) ligand, Tyro3 (TYRO3 protein tyrosine kinase 3), and Axl (anexelekto) RTK expression and activity are increased in IPF. To determine if targeting these RTK pathways would inhibit fibroblast activation and the development of pulmonary fibrosis. Quantitative genomic, proteomic, and functional analyses were used to determine Gas6/TAM (Tyro3, Axl, and Mertk [MER proto-oncogene, tyrosine kinase]) RTK expression and activation in tissues and fibroblasts from normal and IPF lungs. The profibrotic impact of these RTK pathways were also examined in bleomycin-induced pulmonary fibrosis and in SCID/Bg mice that developed pulmonary fibrosis after the intravenous administration of primary IPF fibroblasts. Gas6, Axl, and Tyro3 were increased in both rapidly and slowly progressive IPF compared with normal lung samples and fibroblasts. Targeting these pathways with either specific antibodies directed at Gas6 or Axl, or with small-molecule TAM inhibitors indicated that the small molecule-mediated targeting approach was more efficacious in both in vitro and in vivo studies. Specifically, the TAM receptor inhibitor R428 (also known as BGB324) significantly inhibited the synthetic, migratory, and proliferative properties of IPF fibroblasts compared with the other Gas6/TAM receptor targeting agents. Finally, loss of Gas6 expression decreased lung fibrotic responses to bleomycin and treatment with R428 inhibited pulmonary fibrosis in humanized SCID/Bg mice. Gas6/TAM receptor activity contributes to the activation of pulmonary fibroblasts in IPF, suggesting that targeting this RTK pathway might be an effective antifibrotic strategy in this disease.

  17. Acceptance of Smartphone in Enhancing Patient-Caregivers Relationship

    Directory of Open Access Journals (Sweden)

    Wan Khairuzzaman Wan Ismail

    2012-09-01

    Full Text Available Patients may take more initiative to give more attention to their health as well as foster closer relationship with the caregivers and this has been made possible through smartphone. This paper investigates the perceived usefulness of smartphone among healthcare personnel in a private hospital setting. The study has identified elements which have had impact on individual decision to use smartphones using Technology Acceptance Model (TAM. Questionnaires were distributed to 57 respondents including medical doctors, nurses and head of department of a hospital. The analysis shows that the younger generations were more ‘trendy’ in owning a Smartphone. The study indicates that females reported better acceptance of smartphone use in their works. Healthcare industry will be more patient-centric instead of doctor-centric, hence, it is important for healthcare providers to provide services in line with the customers’ requirement without jeopardizing patient safety and lives.

  18. Porphyromonas gingivalis Promotes Unrestrained Type I Interferon Production by Dysregulating TAM Signaling via MYD88 Degradation.

    Science.gov (United States)

    Mizraji, Gabriel; Nassar, Maria; Segev, Hadas; Sharawi, Hafiz; Eli-Berchoer, Luba; Capucha, Tal; Nir, Tsipora; Tabib, Yaara; Maimon, Avraham; Dishon, Shira; Shapira, Lior; Nussbaum, Gabriel; Wilensky, Asaf; Hovav, Avi-Hai

    2017-01-10

    Whereas type I interferons (IFNs-I) were proposed to be elevated in human periodontitis, their role in the disease remains elusive. Using a bacterial-induced model of murine periodontitis, we revealed a prolonged elevation in IFN-I expression. This was due to the downregulation of TAM signaling, a major negative regulator of IFN-I. Further examination revealed that the expression of certain TAM components was reduced as a result of prolonged degradation of MYD88 by the infection. As a result of such prolonged IFN-I production, innate immunological functions of the gingiva were disrupted, and CD4 + T cells were constitutively primed by dendritic cells, leading to elevated RANKL expression and, subsequently, alveolar bone loss (ABL). Blocking IFN-I signaling restored proper immunological function and prevented ABL. Importantly, a loss of negative regulation on IFN-I expression by TAM signaling was also evident in periodontitis patients. These findings thus suggest a role for IFN-I in the pathogenesis of periodontitis. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Analyzing the effect of customer loyalty on virtual marketing adoption based on theory of technology acceptance model

    Directory of Open Access Journals (Sweden)

    Peyman Ghafari Ashtiani

    2016-08-01

    Full Text Available One of the most advantages of the internet and its expansion is probably due to its easy and low cost access to unlimited information and easy and fast information exchange. The accession of communication technology for marketing area and emergence of the Internet leads to creation and development of new marketing models such as viral marketing. In fact, unlike other marketing methods, the most powerful tool for selling products and ideas are not done by a marketer to a customer but from a customer to another one. The purpose of this research is to analyze the relationship between customers' loyalty and the acceptance of viral marketing based on the theory of technology acceptance model (TAM model among the civil engineers and architects who are the members of Engineering Council in Isfahan (ECI. The research method is descriptive–survey and it is applicable in target. The statistical population includes civil engineers and architects who are the members of Engineering Council in Isfahan including 14400 members. The sample size was determined 762 members based on Cochran sampling formula, the sample was selected as accessible. The data was collected by field method. Analyzing the data and recent research hypothesis, the data was extracted from the questionnaires. Then, all the data was analyzed by computer and SPSS and LISREL software. According to the results of the data, the loyalty of the civil engineers and architects members of ECI was associated with the acceptance and practical involvement of viral marketing.

  20. The relationship between the expression of TAM, survivin and the degree of necrosis of the tumor after cisplatin treatment in osteosarcoma.

    Science.gov (United States)

    Chen, G

    2017-02-01

    To explore the relationship between the expression of TAM, survivin and the degree of necrosis of the tumor after cisplatin treatment in osteosarcoma. The mice model of osteosarcoma S180 were injected with 6 mg/kg/day of cisplatin (observation group) or the same amount of normal saline (control group) for 4 weeks. Mice were sacrificed at days 1, 4, 9, 14, 18, 22 and 28, respectively, 24 h before administration of the drug or saline, and tumor tissues were collected. The size of the tumor samples was measured and the correlation of TAM, survivin expression in osteosarcoma and necrosis degree of tumor tissue after cisplatin treatment was studied using various methods including fluorescence quantitative PCR, enzyme linked immunosorbent assay (ELISA), Western blotting and immunohistochemistry. Fluorescence quantitative PCR showed that the expression of TAM, survivin mRNA in the control group was significantly higher than that in the observation group. Also, the ELISA monitoring showed that the expression of mice TAM, survivin protein in vivo was significantly lower than TAM, survivin protein expression of mice in vivo in the observation group (2.3 µg/l, 1.6 µg/l) relatively to the control group (9.7 mg/l, 10.3 µg/l). Consistent with the Western blot data, ELISA results showed that the expression of survivin and TAM protein decreased gradually with the prolongation of drug treatment along the time in the observation group. The volume and weight of the tumor in the observation group were significantly less than that of the control group. Additionally, the tumor necrosis of mice in the observation group was more significant, suggesting that the meant of the size of tumor tissue decreased significantly with the extension of the time of drug treatment. Immunohistochemical results showed that the rate of the positive cell of TAM and survivin in the observation group (82.3%) was significantly higher (pTAM gradually declined at the level of the trend with the extension of

  1. Introducing the Clean-Tech Adoption Model: A California Case Study

    NARCIS (Netherlands)

    Bijlveld, P.C. (Paul); Riezebos, P. (Peter); Wierstra, E. (Erik)

    2012-01-01

    Abstract. The Clean-Tech Adoption Model (C-TAM) explains the adoption process of clean technology. Based on the Unified Theory of Acceptance and Usage of Technology (UTAUT) combined with qualitative research and empirical data gathering, the model predicts adoption based on the perceived quality,

  2. INTENTION TO PURCHASE VIA THE INTERNET: A COMPARISON OF TWO THEORETICAL MODELS

    Directory of Open Access Journals (Sweden)

    Jasman J. Ma'ruf

    2005-01-01

    Full Text Available This study compares two models for predicting intention to purchase via the Internet. The behavioral intention to purchase via the Internet was examined as a function of attitude towards purchase, perceived usefulness, and perceived ease of use Technology Acceptance Model (TAM, or attitude towards purchase, subjective norm, and perceived risk (Theory of Planned Behavior [TPB]. Results indicate that both models significantly influenced behavioral intention to purchase. We compared both models, and found that TPB (adjusted R2 = 0.55 is better than TAM (0.44 in explaining behavioral intention to purchase (BI. After we integrated TAM and TPB, we found that perceived risk (β = –0.332 is the primary determinant of BI, with subjective norm (SN (β = 0.210 as the significant secondary determinant, followed by attitude (A towards purchase (β = 0.175, perceived usefulness (β = 0.159, and perceived ease of use (β = 0.069.

  3. End-user satisfaction analysis on library management system unnes using technology acceptance model towards national standard of integrated library

    Science.gov (United States)

    Hardyanto, W.; Purwinarko, A.; Adhi, M. A.

    2018-03-01

    The library which is the gate of the University should be supported by the existence of an adequate information system, to provide excellent service and optimal to every user. Library management system that has been in existence since 2009 needs to be re-evaluated so that the system can meet the needs of both operator and Unnes user in particular, and users from outside Unnes in general. This study aims to evaluate and improve the existing library management system to produce a system that is accountable and able to meet the needs of end users, as well as produce a library management system that is integrated Unnes. Research is directed to produce evaluation report with Technology Acceptance Model (TAM) approach and library management system integrated with the national standard.

  4. EVALUASI PENERIMAAN PENGGUNA COMPUTER BASED TEST DENGAN PENDEKATAN TAM DI KULON PROGO

    Directory of Open Access Journals (Sweden)

    Sukasna .

    2017-02-01

    Implementation of national examinations in junior high, high school / vocational equivalent is implemented by the Ministry ofEducation and Culture of the Republic of Indonesia is always changing, both in terms of benefits, technical implementation, thenumber of package models matter up with ways of correcting the results of the exam. Along with the technological development ofnational examinations now begin to be implemented by means of a computer on-line or better known as Computer Based Test (CBT.The purpose of this study was to examine the effect: the experience of the perception of usefulness and ease; complexity to theperception of usefulness and ease; the suitability of tasks to perception of usefulness and ease; perceived ease the perception ofusefulness; perceptions of the usefulness of the attitude of users; perceived ease of the attitude of users; perceptions of the usefulnessof the behavior of interest; user attitude towards the behavior of interest; behavior towards the use of real interest in the use of CBT.The approach used in this study is the Technology Acceptance Model (TAM I think Davis (1989 with SEM method PLS program totest the hypothesis in this study using SEM Based Component Analysis or Partial Least Square (PLS. The results obtained from thisstudy finding significant influence and no significant external variables as well as some of the perceptions that influence theimplementation of CBT in Kulon Progo.

  5. The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans.

    Science.gov (United States)

    Tseng, Rong-Jeng; Armstrong, Kristin R; Wang, Xiaodong; Chamberlin, Helen M

    2007-11-01

    In many organisms, repetitive DNA serves as a trigger for gene silencing. However, some gene expression is observed from repetitive genomic regions such as heterochromatin, suggesting mechanisms exist to modulate the silencing effects. From a genetic screen in C. elegans, we have identified mutations in two genes important for expression of repetitive sequences: lex-1 and tam-1. Here we show that lex-1 encodes a protein containing an ATPase domain and a bromodomain. LEX-1 is similar to the yeast Yta7 protein, which maintains boundaries between silenced and active chromatin. tam-1 has previously been shown to encode a RING finger/B-box protein that modulates gene expression from repetitive DNA. We find that lex-1, like tam-1, acts as a class B synthetic multivulva (synMuv) gene. However, since lex-1 and tam-1 mutants have normal P granule localization, it suggests they act through a mechanism distinct from other class B synMuvs. We observe intragenic (interallelic) complementation with lex-1 and a genetic interaction between lex-1 and tam-1, data consistent with the idea that the gene products function in the same biological process, perhaps as part of a protein complex. We propose that LEX-1 and TAM-1 function together to influence chromatin structure and to promote expression from repetitive sequences.

  6. A Conceptual Model of Technology and E-services Acceptance among Universities\\\\\\' Students (Case Study: Ferdowsi University of Mashhad

    Directory of Open Access Journals (Sweden)

    Shamsodin Nazemi

    2012-12-01

    Full Text Available : In spite of increasing interests and trends among Iranian organizations to incorporate information and communication technology (ICT into service provision to their customers, there is still considerable gap between existing and expected diffusion. The aim of this study was to identify and evaluate main determinants of technology adoption and use on the basis of modified TAM model. The developed model was validated through survey research and data collected from a randomly selected sample of 263 students at Ferdowsi University of Mashhad. Data analysis was conducted using appropriate statistical techniques including regression, and Chaves analysis. The findings of research confirmed the validity of principle model , confirming ease of use and perceived usefulness as main determinants of technology acceptance as suggested by Davis. This study also suggested that the quality of system and personal ability to use technology were good predictors of ease of use, while social interaction and images appeared to be good predictors of perceived usefulness of technology. Furthermore, personal innovativeness proved to have significant effect on intention to use among potential ICT users.

  7. The Use of a Mobile Learning Management System at an Online University and Its Effect on Learning Satisfaction and Achievement

    OpenAIRE

    Won Sug Shin; Minseok Kang

    2015-01-01

    This study investigates online students’ acceptance of mobile learning and its influence on learning achievement using an information system success and extended technology acceptance model (TAM). Structural equation modeling was used to test the structure of individual, social, and systemic factors influencing mobile learning’s acceptance, and how said acceptance influences learning satisfaction and achievement. Unlike earlier TAM-related research that did not provide a broad view of technol...

  8. TAM: a method for enrichment and depletion analysis of a microRNA category in a list of microRNAs.

    Science.gov (United States)

    Lu, Ming; Shi, Bing; Wang, Juan; Cao, Qun; Cui, Qinghua

    2010-08-09

    MicroRNAs (miRNAs) are a class of important gene regulators. The number of identified miRNAs has been increasing dramatically in recent years. An emerging major challenge is the interpretation of the genome-scale miRNA datasets, including those derived from microarray and deep-sequencing. It is interesting and important to know the common rules or patterns behind a list of miRNAs, (i.e. the deregulated miRNAs resulted from an experiment of miRNA microarray or deep-sequencing). For the above purpose, this study presents a method and develops a tool (TAM) for annotations of meaningful human miRNAs categories. We first integrated miRNAs into various meaningful categories according to prior knowledge, such as miRNA family, miRNA cluster, miRNA function, miRNA associated diseases, and tissue specificity. Using TAM, given lists of miRNAs can be rapidly annotated and summarized according to the integrated miRNA categorical data. Moreover, given a list of miRNAs, TAM can be used to predict novel related miRNAs. Finally, we confirmed the usefulness and reliability of TAM by applying it to deregulated miRNAs in acute myocardial infarction (AMI) from two independent experiments. TAM can efficiently identify meaningful categories for given miRNAs. In addition, TAM can be used to identify novel miRNA biomarkers. TAM tool, source codes, and miRNA category data are freely available at http://cmbi.bjmu.edu.cn/tam.

  9. Technology acceptance and purchase intention towards 3G technology among millennial smart phone users: A case of Pakistan

    Directory of Open Access Journals (Sweden)

    Muhammad Jasim

    2016-11-01

    Full Text Available This study aims to investigate the technology acceptance and purchase intention for Third Generation (3G technology in Pakistan’s telecom sector. In such respect, Technology Acceptance Model (TAM has been used to find the effects of the independent variables (Perceived Usefulness, Perceived Ease of Use, Perceived Value, Perceived Enjoyment, Personal Innovativeness and Price on dependent variable (purchase intention. The study population consisted of smartphone users among Millennials in district Haripur-a region in transition towards urbanization. 200 respondents provided the useable data. The results of the study show that perceived usefulness, perceived ease of use, perceived value, perceived enjoyment, personal innovativeness, and price have a significant and positive relationship with purchase intention which validates the growing acceptance of advanced technologies in such regions.

  10. An interview with Patrick Tam by Kathryn Senior.

    Science.gov (United States)

    Tam, Patrick

    2010-12-01

    Patrick Tam's research is focused on the cellular and molecular mechanisms of body patterning during mouse development. He agreed to be interviewed by Development to talk about his interest in mouse development, new concepts in gastrulation, X-linked diseases and his dream of an African safari.

  11. Baby-Crying Acceptance

    Science.gov (United States)

    Martins, Tiago; de Magalhães, Sérgio Tenreiro

    The baby's crying is his most important mean of communication. The crying monitoring performed by devices that have been developed doesn't ensure the complete safety of the child. It is necessary to join, to these technological resources, means of communicating the results to the responsible, which would involve the digital processing of information available from crying. The survey carried out, enabled to understand the level of adoption, in the continental territory of Portugal, of a technology that will be able to do such a digital processing. It was used the TAM as the theoretical referential. The statistical analysis showed that there is a good probability of acceptance of such a system.

  12. Growth Arrest-Specific 6 (Gas6) and TAM Receptors in Mouse Platelets.

    Science.gov (United States)

    Uras, Fikriye; Küçük, Burhanettin; Bingöl Özakpınar, Özlem; Demir, Ahmet Muzaffer

    2015-03-05

    Growth arrest-specific 6 (Gas6) is a newly discovered vitamin K-dependent protein, which is a ligand for TAM receptors [Tyro3 (Sky), Axl, and Mer] from the tyrosine kinase family. Gas6 knockout mice were resistant to venous and arterial thrombosis. There are contradictory reports on the presence of Gas6 and its receptors in mouse platelets. The objective of this study was to investigate whether Gas6 and its receptors were present in mouse platelets or not. Specific pathogen-free BALB/c male and female mice of 8-10 weeks old and 25-30 g in weight were anesthetized under light ether anesthesia and blood samples were taken from their hearts. RNAs were isolated from isolated platelets, and then mRNAs encoding Gas6 and TAM receptors were detected by reverse transcription-polymerase chain reaction (RT-PCR). Protein concentrations of Gas6 and TAM receptors in platelets were measured by ELISA, but not those of Mer, because of the absence of any commercial ELISA kit for mouse specimens. RT-PCR results indicated the presence of mRNAs encoding Gas6 and Mer in mouse platelets. However, although RT-PCR reactions were performed at various temperatures and cycles, we could not detect the presence of mRNAs encoding Axl and Tyro3 (Sky). Receptor protein levels of Axl and Tyro3 were below the detection limits of the ELISA method. We found the presence of mRNAs encoding Gas6 and the receptor Mer in mouse platelets, but not Axl and Tyro3. Gas6, Axl, and Tyro3 protein levels were below the detection limits of the ELISA. The presence of mRNA is not obvious evidence of protein expression in platelets that have no nucleus or DNA. Further studies are required to clarify the presence of Gas6/TAM receptors in platelets using real-time PCR and more sensitive immunological methods, and future studies on mechanisms will indicate whether the Gas6/TAM pathway is a strategy for treatment of disorders.

  13. TAM receptor tyrosine kinase function and the immunopathology of liver disease.

    Science.gov (United States)

    Mukherjee, S K; Wilhelm, A; Antoniades, C G

    2016-06-01

    Tyro3, Axl, MERTK (TAM) receptor tyrosine kinases are implicated in the regulation of the innate immune response through clearance of apoptotic cellular debris and control of cytokine signaling cascades. As a result they are pivotal in regulating the inflammatory response to tissue injury. Within the liver, immune regulatory signaling is employed to prevent the overactivation of innate immunity in response to continual antigenic challenge from the gastrointestinal tract. In this review we appraise current understanding of the role of TAM receptor function in the regulation of both innate and adaptive immunity, with a focus on its impact upon hepatic inflammatory pathology. Copyright © 2016 the American Physiological Society.

  14. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

    Science.gov (United States)

    Paolino, Magdalena; Choidas, Axel; Wallner, Stephanie; Pranjic, Blanka; Uribesalgo, Iris; Loeser, Stefanie; Jamieson, Amanda M; Langdon, Wallace Y; Ikeda, Fumiyo; Fededa, Juan Pablo; Cronin, Shane J; Nitsch, Roberto; Schultz-Fademrecht, Carsten; Eickhoff, Jan; Menninger, Sascha; Unger, Anke; Torka, Robert; Gruber, Thomas; Hinterleitner, Reinhard; Baier, Gottfried; Wolf, Dominik; Ullrich, Axel; Klebl, Bert M; Penninger, Josef M

    2014-03-27

    Tumour metastasis is the primary cause of mortality in cancer patients and remains the key challenge for cancer therapy. New therapeutic approaches to block inhibitory pathways of the immune system have renewed hopes for the utility of such therapies. Here we show that genetic deletion of the E3 ubiquitin ligase Cbl-b (casitas B-lineage lymphoma-b) or targeted inactivation of its E3 ligase activity licenses natural killer (NK) cells to spontaneously reject metastatic tumours. The TAM tyrosine kinase receptors Tyro3, Axl and Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl-b. Treatment of wild-type NK cells with a newly developed small molecule TAM kinase inhibitor conferred therapeutic potential, efficiently enhancing anti-metastatic NK cell activity in vivo. Oral or intraperitoneal administration using this TAM inhibitor markedly reduced murine mammary cancer and melanoma metastases dependent on NK cells. We further report that the anticoagulant warfarin exerts anti-metastatic activity in mice via Cbl-b/TAM receptors in NK cells, providing a molecular explanation for a 50-year-old puzzle in cancer biology. This novel TAM/Cbl-b inhibitory pathway shows that it might be possible to develop a 'pill' that awakens the innate immune system to kill cancer metastases.

  15. MicroRNA‑663b mediates TAM resistance in breast cancer by modulating TP73 expression.

    Science.gov (United States)

    Jiang, Hua; Cheng, Lin; Hu, Pan; Liu, Renbin

    2018-05-23

    Breast cancer is the second leading cause of cancer‑associated mortalities in women. Tamoxifen (TAM) is an endocrine therapy commonly used in the treatment of patients with breast cancer expressing estrogen receptor α. However, treatment often ends in failure due to the emergence of drug resistance. MicroRNAs (miRNAs), a family of small non‑coding RNAs, serve critical roles in the regulation of gene expression and cell events. To date, whether miRNA‑663b could mediate TAM resistance in breast cancer remains unknown. Therefore, the aim of the present study was to investigate the role of miRNA‑663b in TAM resistance in breast cancer. The results demonstrated that miRNA‑663b was upregulated in breast cancer with TAM resistance. Tumor protein 73 (TP73) was a direct target of miRNA‑663b, and was negatively regulated by miRNA‑663b in MCF‑7 cells. Furthermore, it was identified that downregulation of miRNA‑663b inhibited cell proliferation ability and promoted cell apoptosis, resulting in enhanced TAM sensitivity. In addition, these findings suggested that TP73 silencing may have eliminated the effects of miRNA‑663b inhibitor on breast cancer cells. In conclusion, the present study verified a novel molecular link between miRNA‑663b and TP73, and indicated that miRNA‑663b may be a critical therapeutic target in breast cancer.

  16. Genetic diversity and phylogenetic analysis of Tams1 of Theileria annulata isolates from three continents between 2000 and 2012.

    Science.gov (United States)

    Wang, Jiay; Yang, Xianyong; Wang, Yuge; Jing, Zhihong; Meng, Kai; Liu, Jianzhu; Guo, Huijun; Xu, Ruixue; Cheng, Ziqiang

    2014-01-01

    Theileria annulata, which is part of the Theileria sergenti/Theileria buffeli/Theileria orientalis group, preferentially infects cattle and results in high mortality and morbidity in the Mediterranean, Middle East, and Central Asia. The polypeptide Tams1 is an immunodominant major merozoite piroplasm surface antigen of T. annulata that could be used as a marker for epidemiological studies and phylogenetic analysis. In the present study, a total of 155 Tams1 sequences were investigated for genetic diversity and phylogenetic relationships through phylogenetic analysis. Results showed that the Tams1 sequences were divided into two major groups and that distribution for some isolates also exhibited geographic specificity. As targeting polymorphic genes for parasite detection may result in underestimation of infection, polymerase chain reaction (PCR) assay using two different probes targeting tams-1 genes of these two groups can be more credible. In addition, the direction of the spread of the disease was discovered to be from the Mediterranean or the tropical zone to the Eurasian peninsula, Middle East, Southern Asia, and Africa, particularly for Group 2. A similar occurrence was also found between the Ms1 gene of Theileria lestoquardi and the Tams1 gene of T. annulata, which explains cross-immunogenicity to a certain extent. However, no potential glycosylation site in the Tams1 of T. annulata was found in this study, which illustrated that instead of N-glycosylation, other modifications have more significant effects on the immunogenicity of the Tams1 protein.

  17. The Analysis of Electronic Journal Utilization In Learning Process: Technology Acceptance Model And Information System Success

    Directory of Open Access Journals (Sweden)

    Achmad Zaky

    2017-12-01

    Full Text Available This study aims to observe the behavior of electronic journal (e-journal among bachelor students of the Universitas Brawijaya by Technology Acceptance Model (TAM and Information System Success (ISS as theoretical framework. The research samples are all bachelor students who have used e-journal in their learning process. The respondents are selected by convenience sampling method. The data are collected through survey and analyzed by Partial Least Square (PLS with SmartPLS 3. The result of the study reveals that user satisfaction and intention to use have significant effect on actual use of e-journal among bachelor students at the Universitas Brawijaya. Those variables affect the actual use because they have been formed by other variables such as information quality, perceived easiness, perceived usefulness, and attitude towards behavior. Furthermore, information quality has significant influence on user satisfaction, while perceived usefulness and perceived usefulness do not have direct effect on the intention to use. The implication of this study is relevant for educators to recognize the reason factors to use e-journal in the learning process.

  18. Personal and other factors affecting acceptance of smartphone technology by older Chinese adults.

    Science.gov (United States)

    Ma, Qi; Chan, Alan H S; Chen, Ke

    2016-05-01

    It has been well documented that in the 21st century, there will be relatively more older people around the world than in the past. Also, it seems that technology will expand in this era at an unprecedented rate. Therefore, it is of critical importance to understand the factors that influence the acceptance of technology by older people. The positive impact that the use of mobile applications can have for older people was confirmed by a previous study (Plaza et al., 2011). The study reported here aimed to explore and confirm, for older adults in China, the key influential factors of smartphone acceptance, and to describe the personal circumstances of Chinese older adults who use smartphone. A structured questionnaire and face to face individual interviews were used with 120 Chinese older adults (over 55). Structural Equation Modeling was used to confirm a proposed smartphone acceptance model based on Technology Acceptance Model (TAM), and the Unified Theory of Acceptance and Use of Technology (UTAUT). The results showed that those who were younger, with higher education, non-widowed, with better economic condition related to salary or family support were more likely to use smartphone. Also, cost was found to be a critical factor influencing behavior intention. Self-satisfaction and facilitating conditions were proved to be important factors influencing perceived usefulness and perceived ease of use. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  19. TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.

    Science.gov (United States)

    Zheng, Shasha; Hedl, Matija; Abraham, Clara

    2015-02-15

    Microbial-induced cytokine regulation is critical to intestinal immune homeostasis. Acute stimulation of nucleotide-binding oligomerization domain 2 (NOD2), the Crohn's disease-associated sensor of bacterial peptidoglycan, induces cytokines. However, cytokines are attenuated after chronic NOD2 and pattern recognition receptor stimulation of macrophages; similar attenuation is observed in intestinal macrophages. The role of Tyro3, Axl, and Mer (TAM) receptors in regulating chronic pattern recognition receptor stimulation and NOD2-induced outcomes has not been examined. Moreover, TAM receptors have been relatively less investigated in human macrophages. Whereas TAM receptors did not downregulate acute NOD2-induced cytokines in primary human macrophages, they were essential for downregulating signaling and proinflammatory cytokine secretion after chronic NOD2 and TLR4 stimulation. Axl and Mer were similarly required in mice for cytokine downregulation after chronic NOD2 stimulation in vivo and in intestinal tissues. Consistently, TAM expression was increased in human intestinal myeloid-derived cells. Chronic NOD2 stimulation led to IL-10- and TGF-β-dependent TAM upregulation in human macrophages, which, in turn, upregulated suppressor of cytokine signaling 3 expression. Restoring suppressor of cytokine signaling 3 expression under TAM knockdown conditions restored chronic NOD2-mediated proinflammatory cytokine downregulation. In contrast to the upregulated proinflammatory cytokines, attenuated IL-10 secretion was maintained in TAM-deficient macrophages upon chronic NOD2 stimulation. The level of MAPK activation in TAM-deficient macrophages after chronic NOD2 stimulation was insufficient to upregulate IL-10 secretion; however, full restoration of MAPK activation under these conditions restored c-Fos, c-Jun, musculoaponeurotic fibrosarcoma oncogene homolog K, and PU.1 binding to the IL-10 promoter and IL-10 secretion. Therefore, TAM receptors are critical for

  20. Monocyte and plasma expression of TAM ligand and receptor in renal failure: Links to unregulated immunity and chronic inflammation.

    Science.gov (United States)

    Lee, Iris J; Hilliard, Brendan A; Ulas, Mehriban; Yu, Daohai; Vangala, Chandan; Rao, Swati; Lee, Jean; Gadegbeku, Crystal A; Cohen, Philip L

    2015-06-01

    Chronic inflammation is increased in patients with chronic kidney disease (CKD) and contributes to cardiovascular morbidity and mortality. Specific immune mechanisms and pathways that drive and maintain chronic inflammation in CKD are not well described. The TAM ligands (Gas6 and protein S) and receptors (Axl and Mer) have been recently recognized as playing a prominent role in immune regulation. The receptors exist in both soluble and cell-bound forms; the soluble receptors (sAxl and sMer) are believed to compete with the bound receptors and thus inhibit their function. In this study, we determined the expression of cell-bound and soluble TAM proteins in patients with CKD. CKD patients had significantly lower expression of Mer in monocytes, yet increased expression of soluble TAM receptors sAxl and sMer in plasma compared to controls. The metalloproteinase ADAM 17, responsible for cleavage of Mer to its soluble form, was increased in patient monocytes. Elevated levels of soluble TAM receptors were more evident in patients with progressive renal failure. These observations suggest that functional deficiency of TAM receptor-mediated regulation of inflammation may contribute to chronic inflammation in patients with CKD. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. TAM AIRLINES ON TWITTER: COMMUNICATION CHANNEL OR SOCIAL NETWORK?

    Directory of Open Access Journals (Sweden)

    Cynthia Harumy Watanabe Corrêa

    2010-12-01

    Full Text Available The research emphasizes the social appropriation of Information and Communication Technologies by the Brazilian aviation industry, through a case study of communication strategies of TAM on the social networking site Twitter. TAM is a leader in the Brazilian domestic market and gradually conquering its space in Mercosul. This is an exploratory research, based on content analysis of messages sent to the company profile on Twitter, in order to check whether indeed the consolidation of a social network between TAM and its followers. We analyzed all messages posted since July 3, 2009, the date of the first post in the company profile, until the day January 31, 2010. Among the subjects discussed, there was the predominance of information and promotions. The study concludes that, under Twitter, TAM has yet reached a high degree of social interaction with his followers, because the major number of messages is directed to promotional marketing.

  2. [Effect of Evn-50 on cell growth and apoptosis in tamoxifen-resistance human breast cancer cell line MCF-7/TAM-R].

    Science.gov (United States)

    Hu, Hui-yong; Zhou, Jun; Wan, Fang; Dong, Li-feng; Zhang, Feng; Wang, Yi-ke; Chen, Fang-fang; Chen, Yi-ding

    2012-09-01

    To investigate the effect of Evn-50 extracted from Vitex negundo on human breast cancer cell line MCF-7 and MCF-7/TAM-R cells in vitro. MCF-7 and tamoxifen-resistant MCF-7/TAM-R cells were treated with Evn-50,tamoxifen or combination of Evn-50 and tamoxifen. Cell proliferation inhibition rates were determined by MTT assay. The apoptosis rate and the change of cell cycle were detected by PI staining flow cytometry. Protein expression of phospho-MAPK 44/42 (Thr202/Tyr204),MAPK P44/42, phospho-AKT (Ser473) and AKT were detected with Western blotting. The viability of MCF-7 cells was decreased in combination group [(28.65 ±11.43)%] and Evn-50 group [(53.02 ±15.14)%] compared with TAM group (PTAM-R in combination group [(42.11 ±14.30)%] was significantly lower than that in TAM group [(92.18 ±13.16)%] (PTAM-R cells,the expression of phosphorylation of AKT and MAPK44/42 protein was not changed in Evn-50 or TAM alone group,but significantly inhibited in the combination group at 72 h. Evn-50 can inhibit cell growth and induce apoptosis in MCF-7 and MCF-7/TAM-R cells,it can reverse tamoxifen-resistance of MCF-7/TAM-R cells.The mechanisms may be related to the down-regulation of phosphorylated ERK1/2 in MAPK signal pathway and phosphorylated AKT in AKT signal pathway.

  3. Tyura Tam Space Launch Facility, Kazakhstan, CIS

    Science.gov (United States)

    1992-01-01

    Located in Kazakhstan on the Syr Darya River, the Tyura Tam Cosmodrome has been the launch site for 72 cosmonaut crews. The landing runway of the Buran space shuttle can be seen in the left center. Further to the right, near the center is the launch site for the Soyuz. The mission control center is located 1,300 miles away near Moscow. In the lower right, is the city of Leninsk, seen as a dark region next to the river.

  4. Technology acceptance for an Intelligent Comprehensive Interactive Care (ICIC system for care of the elderly: a survey-questionnaire study.

    Directory of Open Access Journals (Sweden)

    Alice M K Wong

    Full Text Available The key components of caring for the elderly are diet, living, transportation, education, and safety issues, and telemedical systems can offer great assistance. Through the integration of personal to community information technology platforms, we have developed a new Intelligent Comprehensive Interactive Care (ICIC system to provide comprehensive services for elderly care. The ICIC system consists of six items, including medical care (physiological measuring system, Medication Reminder, and Dr. Ubiquitous, diet, living, transportation, education (Intelligent Watch, entertainment (Sharetouch, and safety (Fall Detection. In this study, we specifically evaluated the users' intention of using the Medication Reminder, Dr. Ubiquitous, Sharetouch, and Intelligent Watch using a modified technological acceptance model (TAM. A total of 121 elderly subjects (48 males and 73 females were recruited. The modified TAM questionnaires were collected after they had used these products. For most of the ICIC units, the elderly subjects revealed great willingness and/or satisfaction in using this system. The elderly users of the Intelligent Watch showed the greatest willingness and satisfaction, while the elderly users of Dr. Ubiquitous revealed fair willingness in the dimension of perceived ease of use. The old-old age group revealed greater satisfaction in the dimension of result demonstrability for the users of the Medication Reminder as compared to the young-old and oldest-old age groups. The women revealed greater satisfaction in the dimension of perceived ease of use for the users of Dr. Ubiquitous as compared to the men. There were no statistically significant differences in terms of gender, age, and education level in the other dimensions. The modified TAM showed its effectiveness in evaluating the acceptance and characteristics of technologic products for the elderly user. The ICIC system offers a user-friendly solution in telemedical care and improves the

  5. Technology acceptance for an Intelligent Comprehensive Interactive Care (ICIC) system for care of the elderly: a survey-questionnaire study.

    Science.gov (United States)

    Wong, Alice M K; Chang, Wei-Han; Ke, Pei-Chih; Huang, Chun-Kai; Tsai, Tsai-Hsuan; Chang, Hsien-Tsung; Shieh, Wann-Yun; Chan, Hsiao-Lung; Chen, Chih-Kuang; Pei, Yu-Cheng

    2012-01-01

    The key components of caring for the elderly are diet, living, transportation, education, and safety issues, and telemedical systems can offer great assistance. Through the integration of personal to community information technology platforms, we have developed a new Intelligent Comprehensive Interactive Care (ICIC) system to provide comprehensive services for elderly care. The ICIC system consists of six items, including medical care (physiological measuring system, Medication Reminder, and Dr. Ubiquitous), diet, living, transportation, education (Intelligent Watch), entertainment (Sharetouch), and safety (Fall Detection). In this study, we specifically evaluated the users' intention of using the Medication Reminder, Dr. Ubiquitous, Sharetouch, and Intelligent Watch using a modified technological acceptance model (TAM). A total of 121 elderly subjects (48 males and 73 females) were recruited. The modified TAM questionnaires were collected after they had used these products. For most of the ICIC units, the elderly subjects revealed great willingness and/or satisfaction in using this system. The elderly users of the Intelligent Watch showed the greatest willingness and satisfaction, while the elderly users of Dr. Ubiquitous revealed fair willingness in the dimension of perceived ease of use. The old-old age group revealed greater satisfaction in the dimension of result demonstrability for the users of the Medication Reminder as compared to the young-old and oldest-old age groups. The women revealed greater satisfaction in the dimension of perceived ease of use for the users of Dr. Ubiquitous as compared to the men. There were no statistically significant differences in terms of gender, age, and education level in the other dimensions. The modified TAM showed its effectiveness in evaluating the acceptance and characteristics of technologic products for the elderly user. The ICIC system offers a user-friendly solution in telemedical care and improves the quality of

  6. An Exploration of the Factors Influencing the Adoption of an IS Governance Framework

    Science.gov (United States)

    Parker, Sharon L.

    2013-01-01

    This research explored IT governance framework adoption, leveraging established IS theories. It applied both the technology acceptance model (TAM) and the technology, organization, environment (TOE) models. The study consisted of developing a model utilizing TOE and TAM, deriving relevant hypotheses. Interviews with a group of practitioners…

  7. MODELS OF TECHNOLOGY ADOPTION: AN INTEGRATIVE APPROACH

    Directory of Open Access Journals (Sweden)

    Andrei OGREZEANU

    2015-06-01

    Full Text Available The interdisciplinary study of information technology adoption has developed rapidly over the last 30 years. Various theoretical models have been developed and applied such as: the Technology Acceptance Model (TAM, Innovation Diffusion Theory (IDT, Theory of Planned Behavior (TPB, etc. The result of these many years of research is thousands of contributions to the field, which, however, remain highly fragmented. This paper develops a theoretical model of technology adoption by integrating major theories in the field: primarily IDT, TAM, and TPB. To do so while avoiding mess, an approach that goes back to basics in independent variable type’s development is proposed; emphasizing: 1 the logic of classification, and 2 psychological mechanisms behind variable types. Once developed these types are then populated with variables originating in empirical research. Conclusions are developed on which types are underpopulated and present potential for future research. I end with a set of methodological recommendations for future application of the model.

  8. The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.

    Science.gov (United States)

    Gajiwala, Ketan S; Grodsky, Neil; Bolaños, Ben; Feng, Junli; Ferre, RoseAnn; Timofeevski, Sergei; Xu, Meirong; Murray, Brion W; Johnson, Ted W; Stewart, Al

    2017-09-22

    The receptor tyrosine kinase family consisting of Tyro3, Axl, and Mer (TAM) is one of the most recently identified receptor tyrosine kinase families. TAM receptors are up-regulated postnatally and maintained at high levels in adults. They all play an important role in immunity, but Axl has also been implicated in cancer and therefore is a target in the discovery and development of novel therapeutics. However, of the three members of the TAM family, the Axl kinase domain is the only one that has so far eluded structure determination. To this end, using differential scanning fluorimetry and hydrogen-deuterium exchange mass spectrometry, we show here that a lower stability and greater dynamic nature of the Axl kinase domain may account for its poor crystallizability. We present the first structural characterization of the Axl kinase domain in complex with a small-molecule macrocyclic inhibitor. The Axl crystal structure revealed two distinct conformational states of the enzyme, providing a first glimpse of what an active TAM receptor kinase may look like and suggesting a potential role for the juxtamembrane region in enzyme activity. We noted that the ATP/inhibitor-binding sites of the TAM members closely resemble each other, posing a challenge for the design of a selective inhibitor. We propose that the differences in the conformational dynamics among the TAM family members could potentially be exploited to achieve inhibitor selectivity for targeted receptors. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. A study on acceptance of mobileschool at secondary schools in Malaysia: Urban vs rural

    Science.gov (United States)

    Hashim, Ahmad Sobri; Ahmad, Wan Fatimah Wan; Sarlan, Aliza

    2017-10-01

    Developing countries are in dilemma where sophisticated technologies are more advance as compared to the way their people think. In education, there have been many novel approaches and technologies were introduced. However, very minimal efforts were put to apply in our education. MobileSchool is a mobile learning (m-learning) management system, developed for administrative, teaching and learning processes at secondary schools in Malaysia. The paper presents the acceptance of MobileSchool between urban and rural secondary schools in Malaysia. Research framework was designed based on Technology Acceptance Model (TAM). The constructs of the framework include computer anxiety, self-efficacy, facilitating condition, technological complexity, perceived behavioral control, perceive ease of use, perceive usefulness, attitude and behavioral intention. Questionnaire was applied as research instrument which involved 373 students from four secondary schools (two schools in urban category and another two in rural category) in Perak. Inferential analyses using hypothesis and t-test, and descriptive analyses using mean and percentage were used to analyze the data. Results showed that there were no big difference (acceptance constructs between urban and rural secondary schools except computer anxiety.

  10. The Tyrosine Aminomutase TAM1 Is Required for β-Tyrosine Biosynthesis in Rice

    Science.gov (United States)

    Yan, Jian; Aboshi, Takako; Teraishi, Masayoshi; Strickler, Susan R.; Spindel, Jennifer E.; Tung, Chih-Wei; Takata, Ryo; Matsumoto, Fuka; Maesaka, Yoshihiro; McCouch, Susan R.; Okumoto, Yutaka; Mori, Naoki; Jander, Georg

    2015-01-01

    Non-protein amino acids, often isomers of the standard 20 protein amino acids, have defense-related functions in many plant species. A targeted search for jasmonate-induced metabolites in cultivated rice (Oryza sativa) identified (R)-β-tyrosine, an isomer of the common amino acid (S)-α-tyrosine in the seeds, leaves, roots, and root exudates of the Nipponbare cultivar. Assays with 119 diverse cultivars showed a distinct presence/absence polymorphism, with β-tyrosine being most prevalent in temperate japonica cultivars. Genetic mapping identified a candidate gene on chromosome 12, which was confirmed to encode a tyrosine aminomutase (TAM1) by transient expression in Nicotiana benthamiana and in vitro enzyme assays. A point mutation in TAM1 eliminated β-tyrosine production in Nipponbare. Rice cultivars that do not produce β-tyrosine have a chromosome 12 deletion that encompasses TAM1. Although β-tyrosine accumulation was induced by the plant defense signaling molecule jasmonic acid, bioassays with hemipteran and lepidopteran herbivores showed no negative effects at physiologically relevant β-tyrosine concentrations. In contrast, root growth of Arabidopsis thaliana and other tested dicot plants was inhibited by concentrations as low as 1 μM. As β-tyrosine is exuded into hydroponic medium at higher concentrations, it may contribute to the allelopathic potential of rice. PMID:25901084

  11. Impact of Collaborative Work on Technology Acceptance: A Case Study from Virtual Computing

    Directory of Open Access Journals (Sweden)

    Abdullah Konak

    2016-12-01

    Findings\tThe findings of the study supported that collaborative work could improve non-technology students’ acceptance of RVCLs. However, no significant effect of collaborative work on technology acceptance was observed in the case of technology students. Recommendations for Practitioners\tEducators should consider the benefits of collaborative work while introducing a new technology to students who may not have background in the technology introduced. Recommendation for Researchers In this study, student technological background was found to be a significant factor for technology acceptance; hence, it is recommended that technological background is included in TAM studies as an external factor. Future Research\tRepeating similar studies with multiple exercises with varying degrees of challenge is required for a better understanding of how collaborative work and student technological background affect technology acceptance.

  12. Integrated Model for E-Learning Acceptance

    Science.gov (United States)

    Ramadiani; Rodziah, A.; Hasan, S. M.; Rusli, A.; Noraini, C.

    2016-01-01

    E-learning is not going to work if the system is not used in accordance with user needs. User Interface is very important to encourage using the application. Many theories had discuss about user interface usability evaluation and technology acceptance separately, actually why we do not make it correlation between interface usability evaluation and user acceptance to enhance e-learning process. Therefore, the evaluation model for e-learning interface acceptance is considered important to investigate. The aim of this study is to propose the integrated e-learning user interface acceptance evaluation model. This model was combined some theories of e-learning interface measurement such as, user learning style, usability evaluation, and the user benefit. We formulated in constructive questionnaires which were shared at 125 English Language School (ELS) students. This research statistics used Structural Equation Model using LISREL v8.80 and MANOVA analysis.

  13. TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.

    Science.gov (United States)

    Akalu, Yemsratch T; Rothlin, Carla V; Ghosh, Sourav

    2017-03-01

    Cancer immunotherapy utilizing T-cell checkpoint inhibitors has shown tremendous clinical success. Yet, this mode of treatment is effective in only a subset of patients. Unresponsive patients tend to have non-T-cell-inflamed tumors that lack markers associated with the activation of adaptive anti-tumor immune responses. Notably, elimination of cancer cells by T cells is critically dependent on the optimal activity of innate immune cells. Therefore, identifying new targets that regulate innate immune cell function and promote the engagement of adaptive tumoricidal responses is likely to lead to the development of improved therapies against cancer. Here, we review the TAM receptor tyrosine kinases-TYRO3, AXL, and MERTK-as an emerging class of innate immune checkpoints that participate in key steps of anti-tumoral immunity. Namely, TAM-mediated efferocytosis, negative regulation of dendritic cell activity, and dysregulated production of chemokines collectively favor the escape of malignant cells. Hence, disabling TAM signaling may promote engagement of adaptive immunity and complement T-cell checkpoint blockade. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. State-of-the-art of small molecule inhibitors of the TAM family: the point of view of the chemist.

    Science.gov (United States)

    Baladi, Tom; Abet, Valentina; Piguel, Sandrine

    2015-11-13

    The TAM family of tyrosine kinases receptors (Tyro3, Axl and Mer) is implicated in cancer development, autoimmune reactions and viral infection and is therefore emerging as an effective and attractive therapeutic target. To date, only a few small molecules have been intentionally designed to block the TAM kinases, while most of the inhibitors were developed for blocking different protein kinases and then identified through selectivity profile studies. This minireview will examine in terms of chemical structure the different compounds able to act on either one, two or three TAM kinases with details about structure-activity relationships, drug-metabolism and pharmacokinetics properties where they exist. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  15. Factors Influencing E-district Adoption: An Empirical Assessment in Indian Context

    OpenAIRE

    Baishya, Kuldeep; Samalia, Harsh Vardhan; Joshi, Rohit

    2017-01-01

    The purpose of this confirmatory study is to explore the factors influencing the acceptance of e-district services by the citizens inAssam, a North-East state of India. Taking unified theory of acceptance and use of technology (UTAUT), technology acceptance model (TAM) and TAM 3 as the basis, a conceptual framework is developed. The study uses semi-structured interviews, focus groups, and a questionnaire based survey through 166 valid data points to validate the conceptual framework. Moreover...

  16. Technology Acceptance Model: A Survey of Literature

    Directory of Open Access Journals (Sweden)

    Priyanka Surendran

    2013-07-01

    Full Text Available The technology acceptance model has been a theory that is most widely used to explain an individual’s acceptance of an information system. This study has reviewed numerous literatures available in this area. The different studies in this area were evaluated to understand the modifications that were done on this model. The paper then tries to provide an insight on future trends in the technology acceptance model.

  17. Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes.

    Science.gov (United States)

    Wang, Xiaomei; Malawista, Anna; Qian, Feng; Ramsey, Christine; Allore, Heather G; Montgomery, Ruth R

    2018-02-09

    The multifactorial immune deterioration in aging--termed "inflamm-aging"--is comprised of a state of low-grade, chronic inflammation and complex dysregulation of responses to immune stimulation. The TAM family (Tyro 3, Axl, and Mer) of receptor tyrosine kinases are negative regulators of Toll like receptor-mediated immune responses that broadly inhibit cytokine receptor cascades to inhibit inflammation. Here we demonstrate elevated expression of TAM receptors in monocytes of older adults, and an age-dependent difference in signaling mediator AKT resulting in dysregulated responses to signaling though Mer. Our results may be especially significant in tissue, where levels of Mer are highest, and may present avenues for modulation of chronic tissue inflammation noted in aging.

  18. MEASUREMENT FOR ACCEPTANCE OF SUPPLY CHAIN SIMULATOR APPLICATION USING TECHNOLOGY ACCEPTANCE MODEL

    Directory of Open Access Journals (Sweden)

    Mulyati E.

    2018-03-01

    Full Text Available The aim of this research for was to measure the user acceptance of simulator application which was built as a tool for student in learning of supply chain, particularly in bullwhip effect problem. The measurements used for the acceptance of supply chain simulator application in this research was the Technology Acceptance Model from 162 samples which were analyzed with Confirmatory Factor Analysis and Structural Equation Modelling. The result of this research indicated that the user acceptance (shown by customer participation of supply chain simulator was directly influence by perceived usefulness of supply chain simulator application used (positive and significant; the user acceptance of supply chain simulator was indirectly influenced by perceived ease of use in using supply chain simulator application (positive but not significant; the user acceptance of supply chain simulator was indirectly influenced by perceived enjoyment when the supply chain simulator application was used. The research would give a better understanding about a bullwhip effect and better experience for students, which would not be obtained through conventional learning, when the tools were not used.

  19. ANALISIS TEKNIK RAGAM DIALOG DIAGNOSIS PENYAKIT BERBASIS SPK DENGAN SEMPLS

    Directory of Open Access Journals (Sweden)

    Jihadil Qudsi

    2018-04-01

    Full Text Available Decision support systems, commonly called DSS (or SPK in Bahasa, in medical used to diagnose illness. But within its implementation these systems are not used optimally. The main cause is the interface of the systems that is not accordance with the user wants. Three interface designs layouts were proposed for the phase of history and physical examination and two interface designs layouts for investigations to be assessed by the respondents. Based on the results of the questionnaires selected by respondents, statistical tests were performed to determine the value of the use of interface design based on the Technology Acceptance Model (TAM and modified TAM. The statistical methods used to examine the effect of variables on TAM and modified TAM i.e. the Structural Equation Modeling Partial Least Square (SEM PLS method. The results of this study indicate that the respondents’ choice in the TAM and modified TAM model for the history and physical examination is the same as the based filling system. While for the supporting stage there are differences of respondent choice on TAM model with choice of graphical interaction system and on modified TAM model with windowing system option.

  20. Perspectives of Students on Acceptance of Tablets and Self-directed Learning with Technology

    OpenAIRE

    Gokcearslan, Sahin

    2017-01-01

    Recent mobile learning technologies offer the opportunity for students to take charge ofthe learning process both inside and outside the classroom. One of these tools is the tabletPC (hereafter ‘tablet’). In parallel with increased access to e-content, the role of tablets inlearning has recently begun to be examined. This study aims to reveal the relationshipbetween the level of acceptance of tablets (TAM) and the level of selfdirectedlearning with technology (SDLT) of students and to differe...

  1. Modeling patients' acceptance of provider-delivered e-health.

    Science.gov (United States)

    Wilson, E Vance; Lankton, Nancy K

    2004-01-01

    Health care providers are beginning to deliver a range of Internet-based services to patients; however, it is not clear which of these e-health services patients need or desire. The authors propose that patients' acceptance of provider-delivered e-health can be modeled in advance of application development by measuring the effects of several key antecedents to e-health use and applying models of acceptance developed in the information technology (IT) field. This study tested three theoretical models of IT acceptance among patients who had recently registered for access to provider-delivered e-health. An online questionnaire administered items measuring perceptual constructs from the IT acceptance models (intrinsic motivation, perceived ease of use, perceived usefulness/extrinsic motivation, and behavioral intention to use e-health) and five hypothesized antecedents (satisfaction with medical care, health care knowledge, Internet dependence, information-seeking preference, and health care need). Responses were collected and stored in a central database. All tested IT acceptance models performed well in predicting patients' behavioral intention to use e-health. Antecedent factors of satisfaction with provider, information-seeking preference, and Internet dependence uniquely predicted constructs in the models. Information technology acceptance models provide a means to understand which aspects of e-health are valued by patients and how this may affect future use. In addition, antecedents to the models can be used to predict e-health acceptance in advance of system development.

  2. Social Media Usage: Examination of Influencers and Effects

    Science.gov (United States)

    Brooks, Stoney L.

    2013-01-01

    This dissertation is concerned with investigating topics surrounding the phenomenon of social media usage. Essay One draws from the technology acceptance literature by utilizing concepts from the Technology Acceptance Model (TAM), the Unified Theory of Acceptance and Use of Technology (UTAUT), and the model of hedonic technology acceptance. The…

  3. Video Game Acceptance: A Meta-Analysis of the Extended Technology Acceptance Model.

    Science.gov (United States)

    Wang, Xiaohui; Goh, Dion Hoe-Lian

    2017-11-01

    The current study systematically reviews and summarizes the existing literature of game acceptance, identifies the core determinants, and evaluates the strength of the relationships in the extended technology acceptance model. Moreover, this study segments video games into two categories: hedonic and utilitarian and examines player acceptance of these two types separately. Through a meta-analysis of 50 articles, we find that perceived ease of use (PEOU), perceived usefulness (PU), and perceived enjoyment (PE) significantly associate with attitude and behavioral intention. PE is the dominant predictor of hedonic game acceptance, while PEOU and PU are the main determinants of utilitarian game acceptance. Furthermore, we find that respondent type and game platform are significant moderators. Findings of this study provide critical insights into the phenomenon of game acceptance and suggest directions for future research.

  4. A study on Singaporean women's acceptance of using mobile phones to seek health information.

    Science.gov (United States)

    Lim, Sherwin; Xue, Lishan; Yen, Ching Chiuan; Chang, Leanne; Chan, Hock Chuan; Tai, Bee Choo; Duh, Henry Been Lirn; Choolani, Mahesh

    2011-12-01

    This paper is an exploratory study that investigates Singaporean women's acceptance of using mobile phones to seek health information. A mobile web containing health topics was developed to track Singaporean women's actual use of their mobile phones to seek health information. A survey questionnaire measured variables hypothesized to predict Behavioural Intention. The survey responses were then matched to the data collected on actual use. Correlation analysis and hierarchical regression were used to analyze the data collected. Findings revealed that Perceived Usefulness and Self-efficacy positively predicted the intention to use mobile phones to seek health information. The study also confirmed the presence of an intention-behaviour gap among participants. The conversion of intention to actual behaviour hinges on technical concerns and design factors. Prior experiences with health information seeking reinforced women's evaluations of the usefulness of the mobile web application and helped them to feel more self-efficacious about using their mobile phones to seek health information. Using mobile phones to seek health information was found to be complementary to online health information seeking and can be regarded as an alternative source to the internet for seeking health information. This study contributes to the existing literature by applying the Technology Acceptance Model (TAM) in the context of mobile health information seeking, for which there has been a lack of studies, and demonstrated that the inclusion of additional variables can enhance TAM's predictive power. The empirical presence of an intention-behaviour gap calls for future research to investigate the reasons behind the gap. Finally, the findings from this study can serve as input to promote women's use of mobile phones for better self-management of health. 2011 Elsevier Ireland Ltd. All rights reserved.

  5. Pre-Service Teachers' Attitude towards Information and Communication Technology Usage: A Ghanaian Survey

    Science.gov (United States)

    Gyamfi, Stephen Adu

    2017-01-01

    This study employed the Technology Acceptance Model (TAM) to empirically investigate factors that influence Ghanaian pre-service teachers' attitudes towards Information and Communication Technology (ICT) usage. To achieve this aim, the study extended the TAM framework by adding leadership support and job relevance as exogenous variables. Data were…

  6. A Distributive Model of Treatment Acceptability

    Science.gov (United States)

    Carter, Stacy L.

    2008-01-01

    A model of treatment acceptability is proposed that distributes overall treatment acceptability into three separate categories of influence. The categories are comprised of societal influences, consultant influences, and influences associated with consumers of treatments. Each of these categories are defined and their inter-relationships within…

  7. Late Quaternary extinctions: The promise of TAMS 14C dating

    International Nuclear Information System (INIS)

    Martin, P.S.

    1987-01-01

    In the last 30 000 years late Quaternary extinctions eliminated over two-thirds of the large land mammals of America and Australia and most of the endemic land vertebrates on oceanic islands. Specimens of extinct animals yielding too little organic material for measurement in decay counters are suitable for TAMS dating. Initial results support older evidence of an extinction chronology that was catastrophic regionally, transgressive globally, and linked to the spread of prehistoric people. (orig.)

  8. The Use of a Mobile Learning Management System at an Online University and Its Effect on Learning Satisfaction and Achievement

    Science.gov (United States)

    Shin, Won Sug; Kang, Minseok

    2015-01-01

    This study investigates online students' acceptance of mobile learning and its influence on learning achievement using an information system success and extended technology acceptance model (TAM). Structural equation modeling was used to test the structure of individual, social, and systemic factors influencing mobile learning's acceptance, and…

  9. A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.

    Science.gov (United States)

    Anosova, Irina; Melnik, Svitlana; Tripsianes, Konstantinos; Kateb, Fatiha; Grummt, Ingrid; Sattler, Michael

    2015-05-26

    The chromatin remodeling complex NoRC, comprising the subunits SNF2h and TIP5/BAZ2A, mediates heterochromatin formation at major clusters of repetitive elements, including rRNA genes, centromeres and telomeres. Association with chromatin requires the interaction of the TAM (TIP5/ARBP/MBD) domain of TIP5 with noncoding RNA, which targets NoRC to specific genomic loci. Here, we show that the NMR structure of the TAM domain of TIP5 resembles the fold of the MBD domain, found in methyl-CpG binding proteins. However, the TAM domain exhibits an extended MBD fold with unique C-terminal extensions that constitute a novel surface for RNA binding. Mutation of critical amino acids within this surface abolishes RNA binding in vitro and in vivo. Our results explain the distinct binding specificities of TAM and MBD domains to RNA and methylated DNA, respectively, and reveal structural features for the interaction of NoRC with non-coding RNA. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  10. DOE Project 353: TAMS Prototype and production coupling alignment units

    Energy Technology Data Exchange (ETDEWEB)

    Field, K.V.

    1996-02-01

    TAMS is an electronic measurement system used to determine the alignment of turbine-generator shafts at the coupling interface. The displacement transducer is a strain gage based sensor mounted in a portable probe. The measurement system was experiencing zero input drift and temperature induced drift. This project endeavored to determine the source of these problems and to revise a unit to be returned to a customer, Baltimore Gas and Electric (BGE), within a period of five weeks.

  11. OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM.

    Science.gov (United States)

    Cromer, Laurence; Heyman, Jefri; Touati, Sandra; Harashima, Hirofumi; Araou, Emilie; Girard, Chloe; Horlow, Christine; Wassmann, Katja; Schnittger, Arp; De Veylder, Lieven; Mercier, Raphael

    2012-01-01

    Cell cycle control is modified at meiosis compared to mitosis, because two divisions follow a single DNA replication event. Cyclin-dependent kinases (CDKs) promote progression through both meiosis and mitosis, and a central regulator of their activity is the APC/C (Anaphase Promoting Complex/Cyclosome) that is especially required for exit from mitosis. We have shown previously that OSD1 is involved in entry into both meiosis I and meiosis II in Arabidopsis thaliana; however, the molecular mechanism by which OSD1 controls these transitions has remained unclear. Here we show that OSD1 promotes meiotic progression through APC/C inhibition. Next, we explored the functional relationships between OSD1 and the genes known to control meiotic cell cycle transitions in Arabidopsis. Like osd1, cyca1;2/tam mutation leads to a premature exit from meiosis after the first division, while tdm mutants perform an aberrant third meiotic division after normal meiosis I and II. Remarkably, while tdm is epistatic to tam, osd1 is epistatic to tdm. We further show that the expression of a non-destructible CYCA1;2/TAM provokes, like tdm, the entry into a third meiotic division. Finally, we show that CYCA1;2/TAM forms an active complex with CDKA;1 that can phosphorylate OSD1 in vitro. We thus propose that a functional network composed of OSD1, CYCA1;2/TAM, and TDM controls three key steps of meiotic progression, in which OSD1 is a meiotic APC/C inhibitor.

  12. The Role of Voluntariness in Distance Education Students' Usage of a Course Website

    Science.gov (United States)

    Ramayah, T.

    2010-01-01

    This study looks at the usage of a course website among distance learning business management students in a public institution of higher learning in Malaysia. The Technology Acceptance Model (TAM) was used as the basis of the research framework but voluntariness was added as a possible moderating factor. TAM postulates that perceived usefulness…

  13. Gerontechnology acceptance by elderly Hong Kong Chinese: a senior technology acceptance model (STAM).

    Science.gov (United States)

    Chen, Ke; Chan, Alan Hoi Shou

    2014-01-01

    The purpose of this study was to develop and test a senior technology acceptance model (STAM) aimed at understanding the acceptance of gerontechnology by older Hong Kong Chinese people. The proposed STAM extended previous technology acceptance models and theories by adding age-related health and ability characteristics of older people. The proposed STAM was empirically tested using a cross-sectional questionnaire survey with a sample of 1012 seniors aged 55 and over in Hong Kong. The result showed that STAM was strongly supported and could explain 68% of the variance in the use of gerontechnology. For older Hong Kong Chinese, individual attributes, which include age, gender, education, gerontechnology self-efficacy and anxiety, and health and ability characteristics, as well as facilitating conditions explicitly and directly affected technology acceptance. These were better predictors of gerontechnology usage behaviour (UB) than the conventionally used attitudinal factors (usefulness and ease of use).

  14. Exploring the roles of interaction and flow in explaining nurses' e-learning acceptance.

    Science.gov (United States)

    Cheng, Yung-Ming

    2013-01-01

    To provide safe and competent patient care, it is very important that medical institutions should provide nurses with continuing education by using appropriate learning methods. As compared to traditional learning, electronic learning (e-learning) is a more flexible method for nurses' in-service learning. Hence, e-learning is expected to play a pivotal role in providing continuing education for nurses. This study's purpose was to explore the role and relevance of interaction factors, intrinsic motivator (i.e., flow), and extrinsic motivators (i.e., perceived usefulness (PU) and perceived ease of use (PEOU)) in explaining nurses' intention to use the e-learning system. Based on the technology acceptance model (TAM) with the flow theory, this study's research model presents three types of interaction factors, learner-system interaction, instructor-learner interaction, and learner-learner interaction to construct an extended TAM to explore nurses' intention to use the e-learning system. Sample data were gathered from nurses at two regional hospitals in Taiwan. A total of 320 questionnaires were distributed, 254 (79.375%) questionnaires were returned. Consequently, 218 usable questionnaires were analyzed in this study, with a usable response rate of 68.125%. First, confirmatory factor analysis was used to develop the measurement model. Second, to explore the causal relationships among all constructs, the structural model for the research model was tested by using structural equation modeling. First, learner-system interaction, instructor-learner interaction, and learner-learner interaction respectively had significant effects on PU, PEOU, and flow. Next, flow had significant effects on PU and PEOU, and PEOU had a significant effect on PU. Finally, the effects of flow, PU, and PEOU on intention to use were significant. Synthetically speaking, learner-system interaction, instructor-learner interaction, and learner-learner interaction can indirectly make significant

  15. Gap Acceptance Behavior Model for Non-signalized

    OpenAIRE

    Fajaruddin Bin Mustakim

    2015-01-01

    The paper proposes field studies that were performed to determine the critical gap on the multiple rural roadways Malaysia, at non-signalized T-intersection by using The Raff and Logic Method. Critical gap between passenger car and motorcycle have been determined.   There are quite number of studied doing gap acceptance behavior model for passenger car however still few research on gap acceptance behavior model for motorcycle. Thus in this paper, logistic regression models were developed to p...

  16. Development of CANDLES low background HPGe detector and half-life measurement of 180Tam

    Science.gov (United States)

    Chan, W. M.; Kishimoto, T.; Umehara, S.; Matsuoka, K.; Suzuki, K.; Yoshida, S.; Nakajima, K.; Iida, T.; Fushimi, K.; Nomachi, M.; Ogawa, I.; Tamagawa, Y.; Hazama, R.; Takemoto, Y.; Nakatani, N.; Takihira, Y.; Tozawa, M.; Kakubata, H.; Trang, V. T. T.; Ohata, T.; Tetsuno, K.; Maeda, T.; Khai, B. T.; Li, X. L.; Batpurev, T.

    2018-01-01

    A low background HPGe detector system was developed at CANDLES Experimental Hall for multipurpose use. Various low background techniques were employed, including hermatic shield design, radon gas suppression, and background reduction analysis. A new pulse shape discrimination (PSD) method was specially created for coaxial Ge detector. Using this PSD method, microphonics noise and background event at low energy region less than 200 keV can be rejected effectively. Monte Carlo simulation by GEANT4 was performed to acquire the detection efficiency and study the interaction of gamma-rays with detector system. For rare decay measurement, the detector was utilized to detect the nature's most stable isomer tantalum-180m (180Tam) decay. Two phases of tantalum physics run were completed with total livetime of 358.2 days, which Phase II has upgraded shield configuration. The world most stringent half-life limit of 180Tam has been successfully achieved.

  17. Investigating Students' Acceptance of a Statistics Learning Platform Using Technology Acceptance Model

    Science.gov (United States)

    Song, Yanjie; Kong, Siu-Cheung

    2017-01-01

    The study aims at investigating university students' acceptance of a statistics learning platform to support the learning of statistics in a blended learning context. Three kinds of digital resources, which are simulations, online videos, and online quizzes, were provided on the platform. Premised on the technology acceptance model, we adopted a…

  18. An Empirical Study of Online Discussion Forums by Library and Information Science Postgraduate Students using Technology Acceptance Model 3

    Directory of Open Access Journals (Sweden)

    Airen Adetimirin

    2015-06-01

    Full Text Available E-learning is an important trend globally that is believed to enhance the acquisition of knowledge by students within and outside the classroom to improve their academic pursuit. The Online Discussion Forum (ODF is one of the tools that are used for e-learning in Nigerian universities. It facilitates interaction among postgraduate students as they can communicate and share information sources with one another to promote learning. However, the optimum use of this forum is determined by anchor factors in TAM 3 such as computer self-efficacy, perceptions of external control, computer anxiety and computer playfulness. A conceptual model based on TAM 3 was proposed and empirically tested. Using a survey research design and an online questionnaire for 121 Library and Information Science (LIS postgraduate students, the paper demonstrated that computer self-efficacy, perceptions of external control, computer anxiety and computer playfulness have significant influence on the use of ODF. The paper therefore proposes that Online Discussion Forums should be encouraged for learning in postgraduate education.

  19. The Use of a Mobile Learning Management System at an Online University and Its Effect on Learning Satisfaction and Achievement

    Directory of Open Access Journals (Sweden)

    Won Sug Shin

    2015-06-01

    Full Text Available This study investigates online students’ acceptance of mobile learning and its influence on learning achievement using an information system success and extended technology acceptance model (TAM. Structural equation modeling was used to test the structure of individual, social, and systemic factors influencing mobile learning’s acceptance, and how said acceptance influences learning satisfaction and achievement. Unlike earlier TAM-related research that did not provide a broad view of technological acceptance and its impact on learning activities, the present study’s results highlight the relationship between behavioral intention/learning satisfaction and learning achievement. Additionally, this study tests the theoretical model of successful mobile learning by empirically accepting mobile learning management systems. The findings further imply that students at online universities have started to accept mobile technology as a new learning tool; consequently, its acceptance has influenced their learning achievement both directly and indirectly. These discoveries should facilitate a better understanding of students’ usage of mobile learning systems in higher education, and provide timely guidance for its development and implementation.

  20. Structural Equation Modelling in Behavioral Intention to Use Safety Helmet Reminder System

    Directory of Open Access Journals (Sweden)

    Rosli Naida

    2016-01-01

    Full Text Available Motorcycle is one of private transportation which has been widely used in many countries including Malaysia. However, motorcycles are the most dangerous form of motorized transport. Royal Malaysian Police (PDRM statistics recorded that motorcycle is the highest vehicle (45.9% involved in traffic accident compared to other vehicles. The potential cause of the death to the motorcyclist was due to the head injury. One of strategy to mitigate this problem is through proper usage of safety helmet. Therefore, this paper was introduce a new approach on motorcyclist safety by using the Technology Acceptance Model (TAM with additional determinants that contribute to behavioral intention and to increase the proper usage of safety helmets among Malaysian motorcyclists. The Structural Equation Modelling (SEM was used to test the structural TAM proposed. The evaluation for structural model showed the goodness of fit indices are excellent fit. This study found that perceived ease of use, perceived usefulness and social norm are significant towards behavioral intention to use Safety Helmet Reminder System (SHR.

  1. A model for the Acceptance of emerging technology “Pacs” in Iran’s hospitals

    Directory of Open Access Journals (Sweden)

    Fatemeh Saghafi

    2017-03-01

    Full Text Available Development of Pacs is new opportunity for changing in the health system. Pacs including emerging technologies that provide accessibility to medical images via the network. Patient health records will be available through detailed video and film in everywhere and any time and with minimal cost. There is no trustee Pacs now in Iran and officials are looking to set up a center for the development Pacs. Under these conditions, identifying factors affecting the adoption of this technology will be very necessary and useful. This study is a correlation –descriptive research that was conducted in 1393. In this research TAM model is used for technology adoption. Variables affecting the technology extracted from the literature and these variables have been prioritized by the Delphi method and expert’s opinion. The model is analyzed by the structural equation method. Data’s was collected by a questionnaire including 16 items of the questionnaire that in this area was mined and were localized for Pacs technology. The target population was 130 of professionals. results of this study at medical centers using of Pacs technology confirmed, the effect of perceived financial costs on behavioral intention of Pacs (t-value = 12/31, the effect of compatibility on perceived usefulness by users (t-value = 8/74, the effect of image on perceived usefulness by users (t-value = 5/69, the effect of the image on the perceived ease of use (t-value = 12/74. According to the findings of this study, the factors affecting the acceptance Pacs were identified from the perspective of users' behavior. The results can be useful in planning of health system for the fair use of health cares and development and equipping of health centers.

  2. The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells.

    Science.gov (United States)

    Park, Hyun-Jung; Baen, Ji-Yeon; Lee, Ye-Ji; Choi, Youn-Hee; Kang, Jihee Lee

    2012-08-01

    The TAM receptor protein tyrosine kinases Tyro3, Axl, and Mer play important roles in macrophage function. We investigated the roles of the TAM receptors in mediating the induction of hepatocyte growth factor (HGF) during the interaction of macrophages with apoptotic cells. Mer-specific neutralizing antibody, small interfering RNA (siRNA), and a recombinant Mer protein (Mer/Fc) inhibited HGF mRNA and protein expression, as well as activation of RhoA, Akt, and specific mitogen-activated protein (MAP) kinases in response to apoptotic cells. Inhibition of Axl or Tyro3 with specific antibodies, siRNA, or Fc-fusion proteins did not prevent apoptotic cell-induced HGF mRNA and protein expression and did not inhibit activation of the postreceptor signaling molecules RhoA and certain MAP kinases, including extracellular signal-regulated protein kinase and c-Jun NH(2)-terminal kinase. However, Axl- and Tyro3-specific blockers did inhibit the activation of Akt and p38 MAP kinase in response to apoptotic cells. In addition, none of the TAM receptors mediated the effects of apoptotic cells on transforming growth factor-β or epidermal growth factor mRNA expression. However, they were involved in the induction of vascular endothelial growth factor mRNA expression. Our data provide evidence that when macrophages interact with apoptotic cells, only Mer of the TAM-family receptors is responsible for mediating transcriptional HGF production through a RhoA-dependent pathway.

  3. 77 FR 65888 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2012-10-31

    ... requires one hour. Those same individuals will also be asked to complete Technology Acceptance Model....80 $1,044 Staff Semi-Structured Interviews 36 84 32.03 2,691 Technology Acceptance Model Survey 36 42... Technology Assessment Model (TAM) survey. The interview will address up to five key topic areas: Demographics...

  4. 78 FR 942 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2013-01-07

    ... Technology Acceptance Model surveys; each survey response is estimated to take 30 minutes. Clinic staff... Technology Acceptance Model Survey 36 \\a\\ 2.33 30/60 42 Patient Semi-Structured Interviews 64 1 1 64 Patient... the Technology Assessment Model (TAM) survey. The interview will address up to five key topic areas...

  5. Predicting User Acceptance of Collaborative Technologies: An Extension of the Technology Acceptance Model for E-Learning

    Science.gov (United States)

    Cheung, Ronnie; Vogel, Doug

    2013-01-01

    Collaborative technologies support group work in project-based environments. In this study, we enhance the technology acceptance model to explain the factors that influence the acceptance of Google Applications for collaborative learning. The enhanced model was empirically evaluated using survey data collected from 136 students enrolled in a…

  6. Towards controlled mutagenesis with transposons Ac and Tam3

    Energy Technology Data Exchange (ETDEWEB)

    Haring, M; Veken, J; Windrich, R; Kneppers, T; Rommens, C; Nijkamp, H J.J.; Hille, J [Department of Genetics, Free University, Amsterdam (Netherlands)

    1990-01-01

    Full text: The discovery of mobile genetic elements in plants has permitted the use of these transposons for insertional mutagenesis. This applies so far only to Zea mays and Antirrhinum majus, because other plant transposable elements have not been characterised so thoroughly at the genetic and the molecular level. To establish whether transposons (Ac from maize and Tam3 from Antirrhinum) remain mobile in heterologous hosts, either in somatic tissue or after meiosis, a phenotypic assay system for transposition was developed. The separation of the two transposition functions will allow controlled mutagenesis of plant genes. Our results indicate that both transposable elements remain active in heterologous hosts. (author)

  7. A structural model of technology acceptance

    Directory of Open Access Journals (Sweden)

    Etienne Erasmus

    2015-04-01

    Research purpose: The aim of this study was to test the technology acceptance model within a South African SAP® Enterprise Resource Planning user environment. Motivation for the study: No study could be traced in which the technology acceptance model has been evaluated in the South African context. Research approach, design and method: A cross-sectional survey design was used. The 23-item Technology Acceptance Model Questionnaire was deployed amongst SAP® Enterprise Resource Planning users (N = 241. Main findings: The results confirmed significant paths from perceived usefulness of the information system to attitudes towards and behavioural intentions to use it. Furthermore, behavioural intention to use the system predicted actual use thereof. Perceived ease of use indirectly affected attitudes towards and behavioural intentions to use via perceived usefulness of the information system. Practical/managerial implications: Practitioners should build user confidence by ensuring the ease of use of a new system, providing relevant education, training and guidance and reiterating its usefulness and future added value to the user’s job and career. Contribution/value-add: This study contributes to scientific knowledge regarding the influence of individuals’ perceptions of information system usage on their attitudes, behavioural intentions and actual use of such a system.

  8. Electronic medical record in central polyclinic of isfahan oil industry: a case study based on technology acceptance model.

    Science.gov (United States)

    Tavakoli, Nahid; Jahanbakhsh, Maryam; Shahin, Arash; Mokhtari, Habibollah; Rafiei, Maryam

    2013-03-01

    Today, health information technologies are base of health services and Electronic Medical Record is one of them. The purpose of this paper is to investigate the Technology Acceptance Model (TAM) on EMR at Central Polyclinic Oil Industry that is a pioneer in implementation of EMR in Isfahan. This study was an applied and analytical survey that it was done at the Central Polyclinic Oil Industry. Because statistical population were limited, sampling bas been done by conducting the census and the sample was according to the population. The data was collected by a researcher-made questionnaire that it was validated by experts and its reliability was confirmed by test retest. The questionnaire was developed in 5 scopes including external factors (data quality and user interface), perceived usefulness, perceived ease of usefulness, attitude toward using, and behavioral intention to use. The Results analyzed by SPSS. There was a significant relationship between data quality with PU(r=/295, p/005). The survey of the scopes in the polyclinic showed that there is relationship among user interface, perceived usefulness, perceived ease of usefulness, attitude toward using, and behavioral intention to use, but data quality has no relationship with attitude. It seems the system designers didn't consider to data quality characteristics. It is proposed that they consult with health information management professionals for improvement the existing system.

  9. The effect of institutional trust on internet banking acceptance: Perspectives of South African banking retail customers

    Directory of Open Access Journals (Sweden)

    Daniel Maduku

    2016-11-01

    Full Text Available Transactions carried out in the uncertain and impersonal conditions of the Internet require substantial levels of trust. Obtaining customers’ trust is therefore imperative to cultivating and nurturing long-lasting and profitable customer-firm relationships in online environments. Surprisingly however, there is currently a dearth of research on the effects of trust on customers’ acceptance of e-commerce in Africa. This paper investigates the effects of the components of institutional trust on perceptions of ease of use and usefulness, as well as attitudes towards use on customers’ intentions to use Internet banking services. An integrated research model based on the Technology Acceptance Model (TAM was built and empirically tested using data obtained from 390 retail banking customers in South Africa. The results show that the proposed model possesses high explanatory capabilities as it could explain 61 per cent of the variance in Internet banking use intentions. The study results further show that situational normality is neither a salient determinant of customers’ attitudes towards use of internet banking nor their use intention, whereas structural assurance is. By examining the effects of institutional trust on the TAM’s variables, especially in a developing African country, this study does not only provide insights for managers in their efforts to achieve rapid adoption of Internet banking, but also contributes to the literature on the topic.

  10. Forecasting Areas Vulnerable to Forest Conversion in the Tam Dao National Park Region, Vietnam

    Directory of Open Access Journals (Sweden)

    Duong Dang Khoi

    2010-04-01

    Full Text Available Tam Dao National Park (TDNP is a remaining primary forest that supports some of the highest levels of biodiversity in Vietnam. Forest conversion due to illegal logging and agricultural expansion is a major problem that is hampering biodiversity conservation efforts in the TDNP region. Yet, areas vulnerable to forest conversion are unknown. In this paper, we predicted areas vulnerable to forest changes in the TDNP region using multi-temporal remote sensing data and a multi-layer perceptron neural network (MLPNN with a Markov chain model (MLPNN-M. The MLPNN-M model predicted increasing pressure in the remaining primary forest within the park as well as on the secondary forest in the surrounding areas. The primary forest is predicted to decrease from 18.03% in 2007 to 15.10% in 2014 and 12.66% in 2021. Our results can be used to prioritize locations for future biodiversity conservation and forest management efforts. The combined use of remote sensing and spatial modeling techniques provides an effective tool for monitoring the remaining forests in the TDNP region.

  11. APLIKASI MODEL PENERIMAAN TEKNOLOGI DALAM PENGGUNAAN SOFTWARE AUDIT OLEH AUDITOR

    Directory of Open Access Journals (Sweden)

    Dhini Suryandini

    2012-03-01

    Full Text Available Tujuan penelitian ini adalah untuk menguji faktor yang mempengaruhi penerimaan auditor dari perangkat lunak audit dengan menggunakan Model Penerimaan Teknologi (TAM. Data dikumpulkan dengan menggunakan metode survei melalui surat dan email yang dikirim ke auditor di 4 perusahaan-perusahaan CPA di Indonesia. Data dianalisis dengan menggunakan Partial Least Square (PLS. Metode tersebut merupakan metode alternatif Pemodelan Persamaan Struktur dengan menggunakan program aplikasi Smart PLS. Hasil penelitian ini menunjukkan bahwa ada hubungan positif antara perceived usefulness (PU dan attitude terhadap penggunaan audit software (ATT, antara perceived usefulness (PU dan actual use (AU, experience (EXP dan perceived usefulness (PU, dan computer-self-efficacy (CSE dan perceived ease of use (PEOU. Ada 2 faktor yang memiliki pengaruh signifikan baik secara langsung dan tidak langsung pada penerimaan auditor dari perangkat lunak audit. Perceived usefulnes mempunyai pengaruh positif secara langsung terhadap actual use (AU. The aim of this research is to test the factors, influencing the auditor acceptance of audit software by using Technology Acceptance Model (TAM. The data were collected by using survey method through mail and email delivered to the auditors in big 4 CPA’s firms in Indonesia. The data were analyzed by using Partial Least Square (PLS method. It is the alternative method of Structural Equation Modeling (SEM in which Smart PLS application program is applied. The results of this research indicate that there are positive relationship between perceived usefulness (PU and attitude to the use of the audit software (ATT, between perceived usefulness (PU and actual use (AU, between experience (EXP and perceived usefulness (PU, and between computer-self-efficacy (CSE and perceived ease of use (PEOU.  There are 2 factors that have significant influence on the auditor acceptance of audit software directly and indirectly. Perceived

  12. Perceived Usefulness as Key Stimulus to the Behavioral Intention to Use 3G Technology

    Directory of Open Access Journals (Sweden)

    Andy Susilo Lukito Budi

    2011-12-01

    Full Text Available A new technology usually faces the challenge to be accepted by consumers. Because of the unique features of new technology, it needs certain approaches to enhance its acceptance. Technology Acceptance Model (TAM is widely used to study the behavior of organizations and consumers in ac-cepting a new technology. A modified TAM model is applied in the current study to test the impact of advertising appeals of perceived usefulness, perceived ease of use, and social factors on behavioral intention to use 3G technology. Experimental method is utilized on four groups (30 people each of undergraduate students of Atma Jaya Catholic Univesity. The result shows significant impact of the advertising multimedia exposed to the subjects, specifically perceived usefulness. It is concluded that perceived usefulness is the most salient reason among Atma Jaya Catholic University’s students in consuming 3G technology.

  13. Soluble TAM receptor tyrosine kinases in rheumatoid arthritis: correlation with disease activity and bone destruction.

    Science.gov (United States)

    Xu, L; Hu, F; Zhu, H; Liu, X; Shi, L; Li, Y; Zhong, H; Su, Y

    2018-04-01

    The TAM receptor tyrosine kinases (TAM RTK) are a subfamily of receptor tyrosine kinases, the role of which in autoimmune diseases such as systemic lupus erythematosus has been well explored, while their functions in rheumatoid arthritis (RA) remain largely unknown. In this study, we investigated the role of soluble TAM receptor tyrosine kinases (sAxl/sMer/sTyro3) in patients with RA. A total of 306 RA patients, 100 osteoarthritis (OA) patients and 120 healthy controls (HCs) were enrolled into this study. The serum concentrations of sAxl/sMer/sTyro3 were measured by enzyme-linked immunosorbent assay (ELISA), then the associations between sAxl/sMer/sTyro3 levels and clinical features of RA patients were analysed. We also investigated whether sTyro3 could promote osteoclast differentiation in vitro in RA patients. The results showed that compared with healthy controls (HCs), sTyro3 levels in the serum of RA patients were elevated remarkably and sMer levels were decreased significantly, whereas there was no difference between HCs and RA patients on sAxl levels. The sTyro3 levels were correlated weakly but positively with white blood cells (WBC), immunoglobulin (Ig)M, rheumatoid factor (RF), swollen joint counts, tender joint counts, total sharp scores and joint erosion scores. Conversely, there were no significant correlations between sMer levels and the above indices. Moreover, RA patients with high disease activity also showed higher sTyro3 levels. In-vitro osteoclast differentiation assay showed further that tartrate-resistant acid phosphatase (TRAP) + osteoclasts were increased significantly in the presence of sTyro3. Collectively, our study indicated that serum sTyro3 levels were elevated in RA patients and correlated positively with disease activity and bone destruction, which may serve as an important participant in RA pathogenesis. © 2017 British Society for Immunology.

  14. Integration of ICT in teaching and learning: a review of theories ...

    African Journals Online (AJOL)

    In deriving these factors, several theories can be considered. This paper reviews six of these theories, namely, Theory of Reasoned Action (TRA), the Technology Acceptance Model (TAM), the Technology-Organisation-Environment (TOE) framework, the Theory of Planned Behaviour (TPB), the Unified Theory of Acceptance ...

  15. Axelrod model: accepting or discussing

    Science.gov (United States)

    Dybiec, Bartlomiej; Mitarai, Namiko; Sneppen, Kim

    2012-10-01

    Agents building social systems are characterized by complex states, and interactions among individuals can align their opinions. The Axelrod model describes how local interactions can result in emergence of cultural domains. We propose two variants of the Axelrod model where local consensus is reached either by listening and accepting one of neighbors' opinion or two agents discuss their opinion and achieve an agreement with mixed opinions. We show that the local agreement rule affects the character of the transition between the single culture and the multiculture regimes.

  16. Predicting User Acceptance and Continuance Behaviour Towards Location-based Services: The Moderating Effect of Facilitating Conditions on Behavioural Intention and Actual Use

    Directory of Open Access Journals (Sweden)

    Mohamamd Alamgir Hossain

    2017-06-01

    Full Text Available The purpose of this study is to establish and examine the significance of a consumer acceptance and continuance model for location-based services (LBSs through the integration of perceived entertainment gratification (PEG and perceived application quality (PAQ with the technology acceptance model (TAM. By arguing that behavioural intention (BI does not automatically lead to actual use (AU, we investigated the moderating effect of facilitating conditions (FC on the relationship between BI and AU. A quantitative study was conducted in Australia and Bangladesh; data were obtained from multiple sources by systematic sampling of the distribution of questionnaires. For data analysis we applied the partial least square (PLS method. The results indicate that, in both Australia and Bangladesh, perceived usefulness (PU, PEG and PAQ have significant influence on user attitude (UA, which has a subsequent effect on BI. Interestingly, perceived ease of use (PEoU does not have a direct effect on UA but indirectly influences it through PU—confirming the mediating effect of PU. Further, FC has a moderating effect between BI and AU. The implications of these findings and directions for future research directions are also discussed.

  17. The Influence of E-learning Characteristics and Basic Ict Competencies to Actual USAge of E-learning: a Path Diagram Model

    OpenAIRE

    Suarta, I Made; Suwintana, I Ketut

    2015-01-01

    In this paper, the Technology Acceptance Model (TAM) is extent with two external stimulus namely e-learning characteristics and basic ICT (Information and Communication Technology) competencies. The purpose of this study are (1) finding relationship between e-learning characteristics and lecturers' basic ICT competencies with the perceived ease of use and perceived usefulness of e-learning; and (2) determining the effect of e-learning characteristics and lecturer basic ICT competencies to the...

  18. Predictive factors of user acceptance on the primary educational mathematics aids product

    Science.gov (United States)

    Hidayah, I.; Margunani; Dwijanto

    2018-03-01

    Mathematics learning in primary schools requires instructional media. According to Piaget's theory, students are still in the concrete operational stage. For this reason, the development of the primary level mathematics aids is needed to support the development of successful mathematics learning. The stages of this research are the stages of commercialization with preparatory, marketing, and measurement analysis procedures. Promotion as part of marketing is done by doing a demonstration to the teacher. Measurements were performed to explore the predictive factors of user feasibility in adopting the product. Measurements were conducted using the concept of Technology Acceptance Model (TAM). Measurement variables include external variables, perceived usefulness, perceived ease of use, attitude, intention to use, and actual use. The result of this research shows that the contribution of predictive factors of mathematics teachers on the teaching aids product as follows: the external variable and perceived ease of use at 74%, perceived usefulness at 72%, intention to use (behavioral) at 58%, attitude at 52%, and the consequence factor (actual use) at 42%.

  19. PENGARUH TECHNOLOGY ACCEPTANCE MODEL DAN PENGEMBANGANNYA DALAM PERILAKU MENGGUNAKAN CORE BANKING SYSTEM

    Directory of Open Access Journals (Sweden)

    Dessanti Putri Sekti Ari

    2017-03-01

    Full Text Available The purpose of this study was to examine the antecedents that affected the acceptance of individuals in using theCore Banking System through the constructs Technology Acceptance Model and its development. Constructsused in this study were perceived usefulness, perceived ease of use, attitude, social influences, behavioral inten-tion, facilitating conditions, and behavior. Data were collected through survey methods. The samples of thisstudy were employees working in commercial banks in Malang Raya. This study used 136 respondents and wasanalyzed by smart PLS. The result of this study was that the construct of perceived usefulness and perceived easeof use in the Technology Acceptance Model affected attitude and behavior. Attitude and behavior in the Technol-ogy Acceptance Model and social influence which was the development of the Technology Acceptance Modelaffected behavioral intention to use the Core Banking System, as well as the construct of behavioral intention inTechnology Acceptance Model affected behavior, whereas construct of facilitating conditions which was thedevelopment of the Technology Acceptance Model did not affect the behavior on using the Core Banking System.

  20. Perceptions of a Specific Family Communication Application among Grandparents and Grandchildren: An Extension of the Technology Acceptance Model.

    Science.gov (United States)

    Tsai, Tsai-Hsuan; Chang, Hsien-Tsung; Ho, Yi-Lun

    2016-01-01

    Many studies have noted that the use of social networks sites (SNSs) can enhance social interaction among the elderly and that the motivation for the elderly to use SNSs is to keep in contact with remote friends and family or the younger generation. Memotree is designed to promote intergenerational family communication. The system incorporates the Family Tree design concept and provides family communication mechanisms based on the Family Communication Scale. In addition, the system optimizes hardware and interface use to conform to the specific needs of older and substantially younger individuals. Regarding the impact of variables on SNS with respect to the interaction of usability variables in the construction of a cross-generational communication platform, we adopted the TAM model and Chung et al.'s suggestions to promote user acceptance of the proposed Memotree system. A total of 39 grandchildren and 39 grandparents met the criteria and were included in the study. The elderly and young respondents revealed substantial willingness to use and/or satisfaction with using the Memotree system. Empirical results indicate that technology affordances and perceived ease of use have a positive impact on perceived usefulness, while perceived ease of use is affected by technology affordances. Internet self-efficacy and perceived usefulness have a positive impact on the user's behavioral intention toward the system. In addition, this study investigated age as a moderating variable in the model. The results indicate that grandchildren have a larger significant effect on the path between perceived usefulness and behavioral intention than grandparents. This study proposes a more complete framework for investigating the user's behavioral intention and provides a more appropriate explanation of related services for cross-generational interaction with SNS services.

  1. Factors that influence acceptance of web-based e-learning systems for the in-service education of junior high school teachers in Taiwan.

    Science.gov (United States)

    Chen, Hong-Ren; Tseng, Hsiao-Fen

    2012-08-01

    Web-based e-learning is not restricted by time or place and can provide teachers with a learning environment that is flexible and convenient, enabling them to efficiently learn, quickly develop their professional expertise, and advance professionally. Many research reports on web-based e-learning have neglected the role of the teacher's perspective in the acceptance of using web-based e-learning systems for in-service education. We distributed questionnaires to 402 junior high school teachers in central Taiwan. This study used the Technology Acceptance Model (TAM) as our theoretical foundation and employed the Structure Equation Model (SEM) to examine factors that influenced intentions to use in-service training conducted through web-based e-learning. The results showed that motivation to use and Internet self-efficacy were significantly positively associated with behavioral intentions regarding the use of web-based e-learning for in-service training through the factors of perceived usefulness and perceived ease of use. The factor of computer anxiety had a significantly negative effect on behavioral intentions toward web-based e-learning in-service training through the factor of perceived ease of use. Perceived usefulness and motivation to use were the primary reasons for the acceptance by junior high school teachers of web-based e-learning systems for in-service training. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Les gens, et non les choses, calment les eaux de la lagune de Tam ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cathy Egan

    La lagune de Tam Giang au Viet Nam est un habitat naturel presque parfait pour la pêche et l'aquaculture. Longue de plus de 70 km et d'une profondeur moyenne d'à peine deux mètres, la lagune est un milieu des plus productifs, tant pour les espèces d'eau douce que pour les espèces marines. Au cours des dernières ...

  3. What influences patients’ acceptance of a blood pressure telemonitoring service in primary care? A qualitative study

    Directory of Open Access Journals (Sweden)

    Abdullah A

    2016-01-01

    Full Text Available Adina Abdullah,1 Su May Liew,1 Nik Sherina Hanafi,1 Chirk Jenn Ng,1 Pauline Siew Mei Lai,1 Yook Chin Chia,1 Chu Kiong Loo2 1Department of Primary Care Medicine, Faculty of Medicine, University Malaya Primary Care Research Group, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Artificial Intelligence, Faculty of Computer Science and Information Technology, University of Malaya, Kuala Lumpur, Malaysia Background: Telemonitoring of home blood pressure (BP is found to have a positive effect on BP control. Delivering a BP telemonitoring service in primary care offers primary care physicians an innovative approach toward management of their patients with hypertension. However, little is known about patients’ acceptance of such service in routine clinical care.Objective: This study aimed to explore patients’ acceptance of a BP telemonitoring service delivered in primary care based on the technology acceptance model (TAM.Methods: A qualitative study design was used. Primary care patients with uncontrolled office BP who fulfilled the inclusion criteria were enrolled into a BP telemonitoring service offered between the period August 2012 and September 2012. This service was delivered at an urban primary care clinic in Kuala Lumpur, Malaysia. Twenty patients used the BP telemonitoring service. Of these, 17 patients consented to share their views and experiences through five in-depth interviews and two focus group discussions. An interview guide was developed based on the TAM. The interviews were audio-recorded and transcribed verbatim. Thematic analysis was used for analysis.Results: Patients found the BP telemonitoring service easy to use but struggled with the perceived usefulness of doing so. They expressed confusion in making sense of the monitored home BP readings. They often thought about the implications of these readings to their hypertension management and overall health. Patients wanted more feedback from their doctors and

  4. General Attitude and Acceptance of Holography in Teaching Among Lecturers in Nigerian Colleges of Education

    Directory of Open Access Journals (Sweden)

    Suleiman A. Ahmad

    2015-08-01

    Full Text Available E-learning is a byproduct of instructional design. Thus online learning designers, in their approaches are expected to be familiar with the epistemological underpinnings of several theories and their consequences on the process of instruction. In the same vein constructivism holds assumptions, that learning is an active process whereby the learner constructs knowledge base on experience. Secondly, learning occurs when there is disequilibrium. It therefore takes place in a social context. Recently, technological developments are playing an important role in improving the educational process especially the integration of holographic presentation in the area. A hologram is a three-dimensional record of the positive interference of laser light waves. Teacher training in virtual holographic classrooms could help the new teachers adapt to a real problematic classroom with such tools. Nigeria being one of the moderately growing economy and a successful and relatively stable democracy, educational development is always on the increase due to commitment of government in the area. Holography is a virgin area in the Nigerian educational mindset. Colleges of education in Nigeria are basically teacher training institutions. Teachers are the backbone of education every development. This brought about the need of this study to investigate on the perception, appreciation attitude as well as acceptance of holography in teaching among the academicians in colleges of education in the Nigerian context. This study therefore in a small sample of 100 teachers survey opinions and reported the results in a descriptive statistics as well as variance (t-test and ANOVA with regards to gender and designation. On the scale of structural equation modeling (SEM tool and SPSS regression analysis as well, it presents the actual model of the modified technology acceptance model TAM. The finding indicates less positive attitude and less general acceptance of the holographic system

  5. Bomb conversion of CO2 to graphite for radiocarbon measurement by tandem accelerator mass spectrometry (TAMS)

    International Nuclear Information System (INIS)

    Lowe, D.C.; Judd, W.J.

    1985-01-01

    TAMS has extended the scope of radiocarbon dating but improved sample target preparation techniques are still required. In this paper a quick and reliable method for the conversion of CO 2 into graphite targets suitable for radiocarbon dating is presented. In the outlined procedure a single operator can produce 20 graphite targets a day. (author)

  6. Preparation of graphite targets for radiocarbon dating by tandem accelerator mass spectrometer (TAMS)

    International Nuclear Information System (INIS)

    Lowe, D.C.

    1984-01-01

    The introduction of TAMS has exciting implications for radiocarbon dating but improved sample preparation methods are needed. This paper describes a promising method for the conversion of a few milligrams of wood or charcoal into graphite targets for use in a caesium sputter ion source. Targets containing a large proportion of G-type graphite produced large C - currents, but those containing a high proportion of turbostatic Tn graphite were unsatisfactory; the type of graphite in the target is clearly of significance. (author)

  7. INTEGRASI-INTERKONEKSI ILMU PERSPEKTIF TAFSIR SOSIAL TAM (TUHAN ALAM DAN MANUSIA

    Directory of Open Access Journals (Sweden)

    Imron Muttaqin

    2014-12-01

    Full Text Available As a great project, the integration and the inter-connection knowledge need a complex system include philosophy that combine the substantive and position of God (meta-cosmos, macro-cosmos (Nature, and micro-cosmos (The human. The knowledge dichotomy in Islam must be reunited by integration and inter-connection, but that efforts need setting of the mindset to avoid an error logical thinking of understanding about substantive, position and goal. The Social Tafseer TAM (God, Nature and Human is one of alternative way to build the Islamic true logical thinking because it has many purposes in finding Allah`s blessing and also a systematic characteristic in the processes.

  8. Anticancer effect of luteolin is mediated by downregulation of TAM receptor tyrosine kinases, but not interleukin-8, in non-small cell lung cancer cells.

    Science.gov (United States)

    Lee, Youn Ju; Lim, Taeho; Han, Min Su; Lee, Sun-Hwa; Baek, Suk-Hwan; Nan, Hong-Yan; Lee, Chuhee

    2017-02-01

    TAM receptor tyrosine kinases (RTKs), Tyro3, Axl and MerTK, transduce diverse signals responsible for cell survival, growth, proliferation and anti-apoptosis. In the present study, we demonstrated the effect of luteolin, a flavonoid with antioxidant, anti-inflammatory and anticancer activities, on the expression and activation of TAM RTKs and the association with its cytotoxicity in non-small cell lung cancer (NSCLC) cells. We observed the cytotoxic effect of luteolin in parental A549 and H460 cells as well as in cisplatin-resistant A549/CisR and H460/CisR cells. Exposure of these cells to luteolin also resulted in a dose‑dependent decrease in clonogenic ability. Next, luteolin was found to decrease the protein levels of all three TAM RTKs in the A549 and A549/CisR cells in a dose‑dependent manner. In a similar manner, in H460 and H460/CisR cells, the protein levels of Axl and Tyro3 were decreased following luteolin treatment. In addition, Axl promoter activity was decreased by luteolin, indicating that luteolin suppresses Axl expression at the transcriptional level. We next found that luteolin abrogated Axl phosphorylation in response to growth arrest-specific 6 (Gas6), its ligand, implying the inhibitory effect of luteolin on Gas6-induced Axl activation. Ectopic expression of Axl was observed to attenuate the antiproliferative effect of luteolin, while knockdown of the Axl protein level using a gold nanoparticle-assisted gene delivery system increased its cytotoxicity. In contrast to the inhibitory effect of luteolin on the expression of TAM RTKs, interleukin-8 (IL-8) production was not decreased by luteolin in H460 and H460/CisR cells, while IL-8 production/cell was increased. Collectively, our data suggest that TAM RTKs, but not IL-8, are promising therapeutic targets of luteolin to abrogate cell proliferation and to overcome chemoresistance in NSCLC cells.

  9. Informal Tools in Formal Context: Adoption of Web 2.0 Technologies among Geography Student Teachers in Ghana

    Science.gov (United States)

    Gyamfi, Stephen Adu

    2017-01-01

    Despite the popularity of Web 2.0 technologies and their educational benefits in the 21st century classroom environment, their use for teaching and learning purposes is still very limited. This study extended the technology acceptance model (TAM) to empirically examine factors that determine Ghanaian geography student teachers' acceptance of Web…

  10. External Variables as Antecedents of Users Perception in Virtual Library Usage

    Directory of Open Access Journals (Sweden)

    Olusola I. Akinbobola

    2016-05-01

    Full Text Available Several studies extended the Technology Acceptance Model (TAM by examining the antecedents of perceived usefulness and perceived ease of use; the present study looks at demographic aspect of external variables in virtual library use among undergraduate students. The purpose of this study is to identify the demographic factors sex, level of study, cumulative grade point average, and computer knowledge that act as external factors that are antecedents of perceived usefulness and perceived ease of use. The university management makes a large investment in the provision of a virtual library; investigation of the virtual library acceptance by students is important. TAM and theory of reasoned action (TRA are utilised to theoretically test a model for the extension and to predict virtual library acceptance and usage. In a survey study, data was collected by using a structured questionnaire given to 394 randomly selected participants in a private university. Data were analysed by Pearson product moment correlation, multiple and hierarchical regression. The result of the study is consistent with TAM factors examined for explaining virtual library usage. The extension model accounts for 2.5% variance in perceived usefulness, 2.1% in perceived ease of use, 11.7% - 15.2% on intention to use and 7.2% on actual use of virtual library. Implications of the findings of the study on user’s virtual library training are discussed.

  11. Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity.

    Science.gov (United States)

    Recarte-Pelz, Pedro; Tàssies, Dolors; Espinosa, Gerard; Hurtado, Begoña; Sala, Núria; Cervera, Ricard; Reverter, Joan Carles; de Frutos, Pablo García

    2013-03-12

    Growth arrest-specific gene 6 protein (GAS6) and protein S (ProS) are vitamin K-dependent proteins present in plasma with important regulatory functions in systems of response and repair to damage. They interact with receptor tyrosine kinases of the Tyro3, Axl and MerTK receptor tyrosine kinase (TAM) family, involved in apoptotic cell clearance (efferocytosis) and regulation of the innate immunity. TAM-deficient mice show spontaneous lupus-like symptoms. Here we tested the genetic profile and plasma levels of components of the system in patients with systemic lupus erythematosus (SLE), and compare them with a control healthy population. Fifty SLE patients and 50 healthy controls with matched age, gender and from the same geographic area were compared. Genetic analysis was performed in GAS6 and the TAM receptor genes on SNPs previously identified. The concentrations of GAS6, total and free ProS, and the soluble forms of the three TAM receptors (sAxl, sMerTK and sTyro3) were measured in plasma from these samples. Plasma concentrations of GAS6 were higher and, total and free ProS were lower in the SLE patients compared to controls, even when patients on oral anticoagulant treatment were discarded. Those parameters correlated with SLE disease activity index (SLEDAI) score, GAS6 being higher in the most severe cases, while free and total ProS were lower. All 3 soluble receptors increased its concentration in plasma of lupus patients. The present study highlights that the GAS6/ProS-TAM system correlates in several ways with disease activity in SLE. We show here that this correlation is affected by common polymorphisms in the genes of the system. These findings underscore the importance of mechanism of regulatory control of innate immunity in the pathology of SLE.

  12. Factors shaping the user experience on utiliterian websites

    NARCIS (Netherlands)

    Hompe, T.; Leker, J.; Mast, C. van der; Neerincx, M.A.

    2007-01-01

    This paper explores factors that influence the user experience when using utilitarian websites. A theoretical model for the user experience of utilitarian websites is proposed and investigated. This model is an extension of the Technology Acceptance Model (TAM). The effects of perceived ease of use,

  13. Acceptance model of a Hospital Information System.

    Science.gov (United States)

    Handayani, P W; Hidayanto, A N; Pinem, A A; Hapsari, I C; Sandhyaduhita, P I; Budi, I

    2017-03-01

    The purpose of this study is to develop a model of Hospital Information System (HIS) user acceptance focusing on human, technological, and organizational characteristics for supporting government eHealth programs. This model was then tested to see which hospital type in Indonesia would benefit from the model to resolve problems related to HIS user acceptance. This study used qualitative and quantitative approaches with case studies at four privately owned hospitals and three government-owned hospitals, which are general hospitals in Indonesia. The respondents involved in this study are low-level and mid-level hospital management officers, doctors, nurses, and administrative staff who work at medical record, inpatient, outpatient, emergency, pharmacy, and information technology units. Data was processed using Structural Equation Modeling (SEM) and AMOS 21.0. The study concludes that non-technological factors, such as human characteristics (i.e. compatibility, information security expectancy, and self-efficacy), and organizational characteristics (i.e. management support, facilitating conditions, and user involvement) which have level of significance of p<0.05, significantly influenced users' opinions of both the ease of use and the benefits of the HIS. This study found that different factors may affect the acceptance of each user in each type of hospital regarding the use of HIS. Finally, this model is best suited for government-owned hospitals. Based on the results of this study, hospital management and IT developers should have more understanding on the non-technological factors to better plan for HIS implementation. Support from management is critical to the sustainability of HIS implementation to ensure HIS is easy to use and provides benefits to the users as well as hospitals. Finally, this study could assist hospital management and IT developers, as well as researchers, to understand the obstacles faced by hospitals in implementing HIS. Copyright © 2016

  14. Examining the Antecedents of Social Networking Sites Use among CEGEP Students

    Science.gov (United States)

    Doleck, Tenzin; Bazelais, Paul; Lemay, David John

    2017-01-01

    Investigations in technology acceptance in education has largely overlooked certain unique populations like students from the "Collège d'enseignement général et professionnel" (CEGEP) system. In studies examining CEGEP students' use of technology, the Technology Acceptance Model (TAM) perspective has not been taken into account, nor have…

  15. Cross Cultural Analysis of the Use and Perceptions of Web-Based Learning Systems

    Science.gov (United States)

    Arenas-Gaitan, Jorge; Ramirez-Correa, Patricio E.; Rondan-Cataluna, F. Javier

    2011-01-01

    The main objective of this paper is to examine cultural differences and technology acceptances from students of two universities, one is from a European country: Spain, and the other is in Latin America: Chile. Both of them provide their students with e-learning platforms. The technology acceptance model (TAM) and Hofstede's cultural dimensions…

  16. EPR Oximetry Sensor-Developing a TAM Derivative for In Vivo Studies.

    Science.gov (United States)

    Boś-Liedke, Agnieszka; Walawender, Magdalena; Woźniak, Anna; Flak, Dorota; Gapiński, Jacek; Jurga, Stefan; Kucińska, Małgorzata; Plewiński, Adam; Murias, Marek; Elewa, Marwa; Lampp, Lisa; Imming, Peter; Tadyszak, Krzysztof

    2018-06-01

    Oxygenation is one of the most important physiological parameters of biological systems. Low oxygen concentration (hypoxia) is associated with various pathophysiological processes in different organs. Hypoxia is of special importance in tumor therapy, causing poor response to treatment. Triaryl methyl (TAM) derivative radicals are commonly used in electron paramagnetic resonance (EPR) as sensors for quantitative spatial tissue oxygen mapping. They are also known as magnetic resonance imaging (MRI) contrast agents and fluorescence imaging compounds. We report the properties of the TAM radical tris(2,3,5,6-tetrachloro-4-carboxy-phenyl)methyl, (PTMTC), a potential multimodal (EPR/fluorescence) marker. PTMTC was spectrally analyzed using EPR and characterized by estimation of its sensitivity to the oxygen in liquid environment suitable for intravenous injection (1 mM PBS, pH = 7.4). Further, fluorescent emission of the radical was measured using the same solvent and its quantum yield was estimated. An in vitro cytotoxicity examination was conducted in two cancer cell lines, HT-29 (colorectal adenocarcinoma) and FaDu (squamous cell carcinoma) and followed by uptake studies. The stability of the radical in different solutions (PBS pH = 7.4, cell media used for HT-29 and FaDu cells culturing and cytotoxicity procedure, full rat blood and blood plasma) was determined. Finally, a primary toxicity test of PTMTC was carried out in mice. Results of spectral studies confirmed the multimodal properties of PTMTC. PTMTC was demonstrated to be not absorbed by cancer cells and did not interfere with luciferin-luciferase based assays. Also in vitro and in vivo tests showed that it was non-toxic and can be freely administrated till doses of 250 mg/kg BW via both i.v. and i.p. injections. This work illustrated that PTMTC is a perfect candidate for multimodal (EPR/fluorescence) contrast agent in preclinical studies.

  17. Pedagogical Beliefs and Attitudes toward Information and Communication Technology: A Survey of Teachers of English as a Foreign Language in China

    Science.gov (United States)

    Liu, Haixia; Lin, Chin-Hsi; Zhang, Dongbo

    2017-01-01

    Though pedagogical beliefs have been identified as critical factors in the success of technology integration, very few studies have included them in technology-adoption models. The present study revises the Technology Acceptance Model (TAM) by adding teachers' pedagogical beliefs, and tests the revised model among university-level…

  18. A model for the adoption of ICT by health workers in Africa.

    Science.gov (United States)

    Jimoh, Lanrewaju; Pate, Muhammad A; Lin, Li; Schulman, Kevin A

    2012-11-01

    To investigate the potential of information and communication technology (ICT) adoption among maternal and child health workers in rural Nigeria. A prospective, quantitative survey design was used to collect data from quasi-randomly selected clusters of 25 rural health facilities in 5 of the 36 states in Nigeria over a 2-month period from June to July 2010. A total of 200 maternal and child health workers were included in the survey, and the data were analyzed using a modified theory of acceptance model (TAM). There was no significant difference between ICT knowledge and attitude scores across states. There were significant differences in perceived ease of use (PICT application in health varied across worker groups and conflicted with government/employer priorities. Although the objective of this study was exploratory, the results provide insight into the intricacies involved in the deployment of ICT in low-resource settings. Use of an expanded TAM should be considered as a mandatory part of any pre-implementation study of ICT among health workers in sub-Saharan Africa. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  19. Acceptance and Commitment Therapy as a Unified Model of Behavior Change

    Science.gov (United States)

    Hayes, Steven C.; Pistorello, Jacqueline; Levin, Michael E.

    2012-01-01

    The present article summarizes the assumptions, model, techniques, evidence, and diversity/social justice commitments of Acceptance and Commitment Therapy (ACT). ACT focused on six processes (acceptance, defusion, self, now, values, and action) that bear on a single overall target (psychological flexibility). The ACT model of behavior change has…

  20. A Mutual Acculturation Model of Multicultural Campus Climate and Acceptance of Diversity

    Science.gov (United States)

    Simmons, Samantha; Wittig, Michele A.; Grant, Sheila K.

    2010-01-01

    This study examines the relationship between college students’ perceptions of their campus’ multicultural climate and their acceptance of racial/ethnic diversity. A two-mediator model, based on acculturation principles, was successfully fit to survey data from 434 college students of diverse racial/ethnic heritage. Results showed that valuing positive interactions with members of ethnocultural groups other than one’s own is a positive mediator and strength of ethnocultural identity is a (much less important) negative mediator of the relationship between student perceptions of multicultural campus programming and personal acceptance of diverse racial/ethnic groups. Furthermore, each mediator independently contributed to the prediction of such acceptance. Overall, the model accounts for about 25% of the variance in acceptance of diversity and was a better fit to the data than a reverse path model. Follow-up analyses, separately by ethnic group, showed that perceptions of campus programming predicted acceptance of diversity for the White subsample, but not for the Latino subsample. Nevertheless, the two acculturation-related constructs were important for both groups, with the model accounting for 28% and 24% of their respective variances in acceptance of diversity. Practical implications are drawn. PMID:21058809

  1. Yüksek Öğrenimde Öğretim Elemanlarının Teknoloji Kabulü ve Kullanımı: Adnan Menderes Üniversitesinde Ampirik Bir Değerlendirme = Faculty's Acceptance and Use of Technology in Higher Education: An Empirical Assessment at Adnan Menderes University

    Directory of Open Access Journals (Sweden)

    Aykut Hamit TURAN, Bengü Emine ÇOLAKOĞLU

    2008-01-01

    Full Text Available For more than 20 years, Information Technologies, especially personal computer and Internet have been employed in all phases of our lives, especially in education. In today's globalizing world, borders among countries have been dissolved as qualified workforce would easily travel from one country to another. These developments required higher education institutions to provide education by using the latest techniques and technologies and educate highly qualified individuals with worldwide accredited diplomas and certificates at an increasing pace. In order to have such graduates, first instructors and academicians at higher institutions should use new Information and Communication Technologies effectively and efficiently and to do that, we need to know why these faculty members would use or prefer not to use such technologies as a personal choice. In this study, Davis' (1989 Technology Acceptance Model (TAM, which has strong socio-psychological theoretical foundations, has been empirically tested with the help of data collected at one of the newly established universities in Turkey. The study is among the first that tests the TAM, and the results generally support the theory empirically.

  2. The Influence of Framing Effects on Perceived Ease of Use, Perceived Usefulness, and Behavioral Intention in Information Technology Systems

    National Research Council Canada - National Science Library

    Autrey, Jon

    2001-01-01

    .... There is some question as to the necessity of the amount of this spending. This thesis looks at the use of information framing to influence users' perceptions of information technology using the Technology Acceptance Model (TAM...

  3. Customers' Beliefs Behind Business-to-Consumer Electronic Commerce

    OpenAIRE

    Nena Lim

    2001-01-01

    With the rising importance of electronic commerce, it is important for researchers and company executives to understand customers' beliefs behind online shopping behaviour. This proposed study extends the technology acceptance model (TAM) to test the influence of experience, self-efficacy, perceived risk, and social influence on customers' acceptance of the business-to consumer (b2c) e-commerce.

  4. Theory development in health care informatics: Information and communication technology acceptance model (ICTAM) improves the explanatory and predictive power of technology acceptance models.

    Science.gov (United States)

    An, Ji-Young

    2006-01-01

    The purpose of this web-based study was to explain and predict consumers' acceptance and usage behavior of Internet health information and services. Toward this goal, the Information and Communication Technology Acceptance Model (ICTAM) was developed and tested. Individuals who received a flyer through the LISTSERV of HealthGuide were eligible to participate. The study population was eighteen years old and older who had used Internet health information and services for a minimum of 6 months. For the analyses, SPSS (version 13.0) and AMOS (version 5.0) were employed. More than half of the respondents were women (n = 110, 55%). The average age of the respondents was 35.16 years (S.D. = 10.07). A majority reported at least some college education (n = 126, 63%). All of the observed factors accounted for 75.53% of the total variance explained. The fit indices of the structural model were within an acceptable range: chi2/df = 2.38 (chi2 = 1786.31, df = 752); GFI = .71; RMSEA = .08; CFI = .86; NFI = .78. The results of this study provide empirical support for the continued development of ICTAM in the area of health consumers' information and communication technology acceptance.

  5. Plans for modeling rational acceptance of technology

    NARCIS (Netherlands)

    Houkes, W.N.; Pols, A.J.K.; Michelfelder, D.P.; McCarthy, N.; Goldberg, D.E.

    2013-01-01

    We argue that the use-plan analysis of artefact use and design can be combined with the Unified Theory of Acceptance and Use of Technology (UTAUT), a well-tested model for predicting the adoption of information systems in organizational contexts. After presenting the outlines of the use-plan

  6. Towards a Model of Technology Adoption: A Conceptual Model Proposition

    Science.gov (United States)

    Costello, Pat; Moreton, Rob

    A conceptual model for Information Communication Technology (ICT) adoption by Small Medium Enterprises (SMEs) is proposed. The research uses several ICT adoption models as its basis with theoretical underpinning provided by the Diffusion of Innovation theory and the Technology Acceptance Model (TAM). Taking an exploratory research approach the model was investigated amongst 200 SMEs whose core business is ICT. Evidence from this study demonstrates that these SMEs face the same issues as all other industry sectors. This work points out weaknesses in SMEs environments regarding ICT adoption and suggests what they may need to do to increase the success rate of any proposed adoption. The methodology for development of the framework is described and recommendations made for improved Government-led ICT adoption initiatives. Application of the general methodology has resulted in new opportunities to embed the ethos and culture surrounding the issues into the framework of new projects developed as a result of Government intervention. A conceptual model is proposed that may lead to a deeper understanding of the issues under consideration.

  7. Predicting nurses' use of healthcare technology using the technology acceptance model: an integrative review.

    Science.gov (United States)

    Strudwick, Gillian

    2015-05-01

    The benefits of healthcare technologies can only be attained if nurses accept and intend to fully use them. One of the most common models utilized to understand user acceptance of technology is the Technology Acceptance Model. This model and modified versions of it have only recently been applied in the healthcare literature among nurse participants. An integrative literature review was conducted on this topic. Ovid/MEDLINE, PubMed, Google Scholar, and CINAHL were searched yielding a total of 982 references. Upon eliminating duplicates and applying the inclusion and exclusion criteria, the review included a total of four dissertations, three symposium proceedings, and 13 peer-reviewed journal articles. These documents were appraised and reviewed. The results show that a modified Technology Acceptance Model with added variables could provide a better explanation of nurses' acceptance of healthcare technology. These added variables to modified versions of the Technology Acceptance Model are discussed, and the studies' methodologies are critiqued. Limitations of the studies included in the integrative review are also examined.

  8. A proposed model of factors influencing hydrogen fuel cell vehicle acceptance

    Science.gov (United States)

    Imanina, N. H. Noor; Kwe Lu, Tan; Fadhilah, A. R.

    2016-03-01

    Issues such as environmental problem and energy insecurity keep worsening as a result of energy use from household to huge industries including automotive industry. Recently, a new type of zero emission vehicle, hydrogen fuel cell vehicle (HFCV) has received attention. Although there are argues on the feasibility of hydrogen as the future fuel, there is another important issue, which is the acceptance of HFCV. The study of technology acceptance in the early stage is a vital key for a successful introduction and penetration of a technology. This paper proposes a model of factors influencing green vehicle acceptance, specifically HFCV. This model is built base on two technology acceptance theories and other empirical studies of vehicle acceptance. It aims to provide a base for finding the key factors influencing new sustainable energy fuelled vehicle, HFCV acceptance which is achieved by explaining intention to accept HFCV. Intention is influenced by attitude, subjective norm and perceived behavioural control from Theory of Planned Behaviour and personal norm from Norm Activation Theory. In the framework, attitude is influenced by perceptions of benefits and risks, and social trust. Perceived behavioural control is influenced by government interventions. Personal norm is influenced by outcome efficacy and problem awareness.

  9. An extension of trust and TAM model with IDT in the adoption of the electronic logistics information system in HIS in the medical industry.

    Science.gov (United States)

    Tung, Feng-Cheng; Chang, Su-Chao; Chou, Chi-Min

    2008-05-01

    Ever since National Health Insurance was introduced in 1995, the number of insurants increased to over 96% from 50 to 60%, with a continuous satisfaction rating of about 70%. However, the premium accounted for 5.77% of GDP in 2001 and the Bureau of National Health Insurance had pressing financial difficulties, so it reformed its expenditure systems, such as fee for service, capitation, case payment and the global budget system in order to control the rising medical costs. Since the change in health insurance policy, most hospitals attempted to reduce their operating expenses and improve efficiency. Introducing the electronic logistics information system is one way of reducing the cost of the department of central warehouse and the nursing stations. Hence, the study proposes a technology acceptance research model and examines how nurses' acceptance of the e-logistics information system has been affected in the medical industry. This research combines innovation diffusion theory, technology acceptance model and added two research parameters, trust and perceived financial cost to propose a new hybrid technology acceptance model. Taking Taiwan's medical industry as an experimental example, this paper studies nurses' acceptance of the electronic logistics information system. The structural equation modeling technique was used to evaluate the causal model and confirmatory factor analysis was performed to examine the reliability and validity of the measurement model. The results of the survey strongly support the new hybrid technology acceptance model in predicting nurses' intention to use the electronic logistics information system. The study shows that 'compatibility', 'perceived usefulness', 'perceived ease of use', and 'trust' all have great positive influence on 'behavioral intention to use'. On the other hand 'perceived financial cost' has great negative influence on behavioral intention to use.

  10. Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.

    Directory of Open Access Journals (Sweden)

    Katharina Galmbacher

    Full Text Available A tumor promoting role of macrophages has been described for a transgenic murine breast cancer model. In this model tumor-associated macrophages (TAMs represent a major component of the leukocytic infiltrate and are associated with tumor progression. Shigella flexneri is a bacterial pathogen known to specificly induce apotosis in macrophages. To evaluate whether Shigella-induced removal of macrophages may be sufficient for achieving tumor regression we have developed an attenuated strain of S. flexneri (M90TDeltaaroA and infected tumor bearing mice. Two mouse models were employed, xenotransplantation of a murine breast cancer cell line and spontanous breast cancer development in MMTV-HER2 transgenic mice. Quantitative analysis of bacterial tumor targeting demonstrated that attenuated, invasive Shigella flexneri primarily infected TAMs after systemic administration. A single i.v. injection of invasive M90TDeltaaroA resulted in caspase-1 dependent apoptosis of TAMs followed by a 74% reduction in tumors of transgenic MMTV-HER-2 mice 7 days post infection. TAM depletion was sustained and associated with complete tumor regression.These data support TAMs as useful targets for antitumor therapy and highlight attenuated bacterial pathogens as potential tools.

  11. Customers' Beliefs Behind Business-to-Consumer Electronic Commerce

    Directory of Open Access Journals (Sweden)

    Nena Lim

    2001-11-01

    Full Text Available With the rising importance of electronic commerce, it is important for researchers and company executives to understand customers' beliefs behind online shopping behaviour. This proposed study extends the technology acceptance model (TAM to test the influence of experience, self-efficacy, perceived risk, and social influence on customers' acceptance of the business-to consumer (b2c e-commerce.

  12. The History of UTAUT Model and Its Impact on ICT Acceptance and Usage by Academicians

    Science.gov (United States)

    Oye, N. D.; Iahad, N. A.; Rahim, N. Ab.

    2014-01-01

    This paper started with the review of the history of technology acceptance model from TRA to UTAUT. The expected contribution is to bring to lime light the current development stage of the technology acceptance model. Based on this, the paper examined the impact of UTAUT model on ICT acceptance and usage in HEIs. The UTAUT model theory was…

  13. User acceptance of a picture archiving and communication system (PACS in a Saudi Arabian hospital radiology department

    Directory of Open Access Journals (Sweden)

    Aldosari Bakheet

    2012-05-01

    Full Text Available Abstract Background Compared with the increasingly widespread use of picture archiving and communication systems (PACSs, knowledge concerning users’ acceptance of such systems is limited. Knowledge of acceptance is needed given the large (and growing financial investment associated with the implementation of PACSs, and because the level of user acceptance influences the degree to which the benefits of the systems for healthcare can be realized. Methods A Technology Acceptance Model (TAM was used to assess the level of acceptance of the host PACS by staff in the radiology department at King Abdulaziz Medical City (KAMC, Riyadh, Saudi Arabia. A questionnaire survey of 89 PACS users was employed to obtain data regarding user characteristics, perceived usefulness (PU (6 items, perceived ease of use (PEU (4 items, a change construct (4 items, and a behavior (acceptance construct (9 items. Respondents graded each item in each construct using five-point likert scales. Results Surveyed users reported high levels of PU (4.33/5, PEU (4.15/5, change (4.26/5, and acceptance (3.86/5. The three constructs of PU, PEU, and change explained 41 % of the variation in PACS user acceptance. PU was the most important predictor, explaining 38 % of the variation on its own. The most important single item in the explanatory constructs was that users found PACS to have improved the quality of their work in providing better patient care. Technologists had lower acceptance ratings than did clinicians/radiologists, but no influence on acceptance level was found due to gender, age, or length of experience using the PACS. Although not directly measured, there appeared to be no cultural influence on either the level of acceptance or its determinants. Conclusions User acceptance must be considered when an organization implements a PACS, in order to enhance its successful adoption. Health organizations should adopt a PACS that offers all required functions and which is

  14. Acceptance of Addiction Prevention Exiting Methods and Presentation of Appropriate Model

    Directory of Open Access Journals (Sweden)

    Ali Asghar Savad-Kouhi

    2006-10-01

    Full Text Available Objective: The aim of this study is assessment of acceptance of addiction prevention existing methods and design and present of appropriate model. Materials & Methods: This research has done by survey and desariptive method by using questionnaire we assessed knowledge and belief of people about suggesting and existing methods of addiction prevention and their acceptence and finally design new and appropriate model of addiction prevention. For designing questionnaire, first exports and professors were openly interviewed and according their views final questionnaire was planned. We used questionnaire with 2 open ended and 61 close-ended tests for gathering data. The subjects of research were 2500 persons 13-35 years old that were selected by randomized sampling from 15 provinces. Results: The findings showed that according to people who were studied, they have positive beliefs about prevention methods and their effectiveness. According to findings a good model is inclusive model that able to do in four level: knowledge, change believe and attitude, control and change behavior. Conclusion: The people of study belive that acceptance of suggesting and existing methods of addiction prevention are effective direct and indirect to others, and appropriate model is inclusive model.

  15. Research Article Special Issue

    African Journals Online (AJOL)

    pc

    2018-05-16

    May 16, 2018 ... 1Faculty of Business Management, Universiti Technologi MARA, 23000 ... adopted from the Technology Acceptance Model (TAM). ..... [2] Graupner E, Melcher F, Demers D, and Maedche, A. Customers' intention to use digital ... International Journal of Innovation, Management and Technology, 2012,.

  16. TAM MALİYET VE NORMAL MALİYET YÖNTEMLERİNİN UFRS (TFRS) VE BOBİ FRS’DEKİ DÜZENLEMELER ÇERÇEVESİNDE İNCELENMESİ

    OpenAIRE

    Gökçen, Gürbüz; ÖZTÜRK, Erkan

    2018-01-01

    Tam maliyet yöntemi güvenilir bir ölçümlemearacı olarak kabul edilmesi nedeniyle uzun yıllar boyunca birçok işletmetarafından kullanılmıştır. Bununla birlikte, maliyet ölçümlemesinde yöntemineksik yanları zaman içerisinde tespit edilmiş ve alternatif yöntemlergeliştirilmiştir. Günümüzde Uluslararası Finansal Raporlama Standartları (UFRS)setinde ve bu setin Türkçe tercümesi olan Türkiye Finansal RaporlamaStandartları (TFRS) setinde maliyet ölçümlemesinin tam maliyet yöntemi yerinenormal maliye...

  17. An acceptance model for smart glasses based tourism augmented reality

    Science.gov (United States)

    Obeidy, Waqas Khalid; Arshad, Haslina; Huang, Jiung Yao

    2017-10-01

    Recent mobile technologies have revolutionized the way people experience their environment. Although, there is only limited research on users' acceptance of AR in the cultural tourism context, previous researchers have explored the opportunities of using augmented reality (AR) in order to enhance user experience. Recent AR research lack works that integrates dimensions which are specific to cultural tourism and smart glass specific context. Hence, this work proposes an AR acceptance model in the context of cultural heritage tourism and smart glasses capable of performing augmented reality. Therefore, in this paper we aim to present an AR acceptance model to understand the AR usage behavior and visiting intention for tourists who use Smart Glass based AR at UNESCO cultural heritage destinations in Malaysia. Furthermore, this paper identifies information quality, technology readiness, visual appeal, and facilitating conditions as external variables and key factors influencing visitors' beliefs, attitudes and usage intention.

  18. Responsible technology acceptance

    DEFF Research Database (Denmark)

    Toft, Madeleine Broman; Schuitema, Geertje; Thøgersen, John

    2014-01-01

    As a response to climate change and the desire to gain independence from imported fossil fuels, there is a pressure to increase the proportion of electricity from renewable sources which is one of the reasons why electricity grids are currently being turned into Smart Grids. In this paper, we focus...... on private consumers’ acceptance of having Smart Grid technology installed in their home. We analyse acceptance in a combined framework of the Technology Acceptance Model and the Norm Activation Model. We propose that individuals are only likely to accept Smart Grid technology if they assess usefulness...... in terms of a positive impact for society and the environment. Therefore, we expect that Smart Grid technology acceptance can be better explained when the well-known technology acceptance parameters included in the Technology Acceptance Model are supplemented by moral norms as suggested by the Norm...

  19. Assessing the Adoption of e-Government Services by Teachers in Greece

    Directory of Open Access Journals (Sweden)

    Vasiliki Vrana

    2012-05-01

    Full Text Available Technological developments and governments’ understanding of what citizens need usually determine the design of public online services. For successful implementation of e-Government services, governments have to place the user in the center of future developments, understand what citizens need and measure what increases citizens’ willingness to adopt e-government services. The paper uses the Technology Acceptance Model (TAM, the extended TAM, the Diffusion of Innovations (DOI theory and the important determinants of user acceptance perceived risk and trust, in order to describe teachers’ behavioral intensions to adopt e-Government services. A model containing trust and risk, along with cognitive, social and intrinsic factors is used to study the intentions of e-Government use by Greek primary and secondary education teachers. Two hundred and thirty teachers responded to an online survey. Findings reveal that cognitive and intrinsic factors have significant effects on intentions to use e-Government websites.

  20. Bayesian methodology for reliability model acceptance

    International Nuclear Information System (INIS)

    Zhang Ruoxue; Mahadevan, Sankaran

    2003-01-01

    This paper develops a methodology to assess the reliability computation model validity using the concept of Bayesian hypothesis testing, by comparing the model prediction and experimental observation, when there is only one computational model available to evaluate system behavior. Time-independent and time-dependent problems are investigated, with consideration of both cases: with and without statistical uncertainty in the model. The case of time-independent failure probability prediction with no statistical uncertainty is a straightforward application of Bayesian hypothesis testing. However, for the life prediction (time-dependent reliability) problem, a new methodology is developed in this paper to make the same Bayesian hypothesis testing concept applicable. With the existence of statistical uncertainty in the model, in addition to the application of a predictor estimator of the Bayes factor, the uncertainty in the Bayes factor is explicitly quantified through treating it as a random variable and calculating the probability that it exceeds a specified value. The developed method provides a rational criterion to decision-makers for the acceptance or rejection of the computational model

  1. Polychlorinated biphenyls in sediments of the Tam Giang-Cau Hai Lagoon (Central Vietnam). First results

    Energy Technology Data Exchange (ETDEWEB)

    Frignani, M.; Bellucci, L.G.; Albertazzi, S. [Istituto di Scienze Marine, Sezione di Geologia Marina, CNR, Bologna (Italy); Piazza, R.; Moret, I. [Univ. Ca Foscari, Venezia (Italy). Dip. Scienze Ambientali; Huu, Cu Nguyen [Haiphong Institute of Oceanology, Haiphong City (Viet Nam); Zangrando, R. [Istituto per la Dinamica dei Processi Ambientali, CNR, Venezia (Italy)

    2004-09-15

    The Tam Giang-Cau Hai (TG-CH) Lagoon, a typical tropical coastal wetland, is the largest in southeast Asia, being 70 km long with a surface of 216 km{sup 2}. This system is quite complex because it is composed of four parts with different shapes and extension called Pha Tam Giang (27 km long, 0.6-3.5 km wide, up to 2m deep), Dam Sam-An Truyen (5x5.5 km, 2 m deep), Dam Thuy Tu (24.5 km long, 0.8-2.6 km wide, up to 4 m deep) and Dam Cau Hai (a southernmost, semi circular basin 17 km wide and 1-1.5 m deep). Characteristics and problems of the TG-CH lagoon were extensively described by Frignani et al. In particular, this environment is now facing many critical problems such as oil pollution, coliform contamination, eutrophication and presence of anthropogenic chemicals. This situation requires a management, capable to reverse the negative trend, that should be based on a sound scientific background. However, so far, the research-based knowledge on the key environmental processes and the levels, sources and trends of contamination is rather poor, especially regarding the most dangerous organic species. The purpose of this work was to provide a first insight on the presence of PCBs in lagoon sediments with a particular attention to the history and trends of the inputs.

  2. INTENSI MAHASISWA YOGYAKARTA BERWIRAUSAHA BERBASIS TEKNOLOGI INFORMASI (TI

    Directory of Open Access Journals (Sweden)

    Heru Kurnianto Tjahjono

    2015-11-01

    Full Text Available AbstractThe purpose of this study is to investigate intention to be entrepreneur among university students in Yogyakarta. Based on modification of TPB (theory of planned behavior and TAM (technology acceptance model, this research specifically examined whether entrepreneur’s personality is an important antecedent to explain attitude, risk perception and subjective norm of entrepreneur based on information technology (IT. This research tested whether attitude, risk perception and subjective norm of entrepreneur based on IT are important predictors to explain students’ intention to become entrepreneur based on IT. This research is a replication model proposed by Tjahjono and Palupi (2014. The samples in this research were 300 students from four large universities in Yogyakarta with purposive technique and were analyzed using structural equation modeling (SEM. The results of this research showed that attitude, risk perception, and subjective norm are consequences of entrepreneur’s personality and at the same time as antecedents to explain students’ intentions to be entrepreneur based on IT.Keywords: TPB, TAM and students intention to be entrepreneur.AbstrakPenelitian ini bertujuan untuk menginvestigasi intensi mahasiswa di Yogyakarta berwirausaha. Berbasis pada modifikasi TPB (theory of planned behavior dan TAM (technology acceptance model, penelitian ini secara spesifik menguji apakah kepribadian berwirausaha merupakan anteseden penting dalam menjelaskan sikap, persepsi resiko dan norma subjektif berwirausaha yang berbasis TI. Selanjutnya apakah sikap, persepsi resiko dan norma subjektif berwirausaha berbasis TI adalah prediktor penting dalam menjelaskan intensi mahasiswa berwirausaha yang berbasis TI. Penelitian ini merupakan replikasi model yang diajukan Tjahjono dan Palupi (2014. Sampel dalam penelitian ini adalah 300 mahasiswa 4 perguruan tinggi besar di Yogyakarta dengan teknik penyampelan secara purposive. Penelitian ini dianalisis

  3. Factors Affecting Adoption of Facebook: An Exploratory Study of the LIS Community Perspective

    Science.gov (United States)

    Aharony, Noa

    2014-01-01

    This study seeks to investigate whether information professionals, as well as LIS students, are ready to assimilate Facebook in their work and educational environments. The study uses the Technology Acceptance Model (TAM) as well as some characteristics of the "Big Five" model of personality as a theoretical base from which to predict…

  4. Blended learning in a first-year language class: Evaluating the acceptance of an interactive learning environment

    Directory of Open Access Journals (Sweden)

    Jako Olivier

    2016-10-01

    Full Text Available Increasingly blended learning, as a combination of face-to-face and online instruction is applied in university classrooms. In this study the use of an interactive learning environment (ILE, within a Sakai-based learning management system, as well as face-to-face teaching and learning in a first-year Afrikaans language class is explored. The Technology Acceptance Model (TAM was employed by means of a survey and the Structure Equation Model was used to explore factors relevant to this first-year class. In addition, qualitative research was conducted through an open questionnaire in order to determine the perceptions regarding the blended learning context and the ILE. It was found that students are generally able to function within the ILE and they are quite positive towards the use of the learning environment for learning and teaching. However, it is clear that some students still prefer printed study material. Despite the fact that students indicated that they use the ILE daily, actual usage statistics did not always correspond. Finally, this paper makes suggestions with regard to adapting teaching in terms of students’ behaviour based on their computer anxiety and Internet self-efficacy as well as the perceived usefulness and ease of use of the ILE.

  5. Author Details

    African Journals Online (AJOL)

    Legalising sex workers during the 2010 FIFA Soccer World CupTM in South ... Application of the Technology Acceptance Model (TAM) in electronic ticket purchase for the 2010 ... Relationship between Social Contract, Anxiety, Performance, Workload and Intention to Quit Among Professional ... AJOL African Journals Online.

  6. Assessing acceptance of assistive social agent technology by older adults: the Almere model

    NARCIS (Netherlands)

    Heerink, M.; Kröse, B.; Evers, V.; Wielinga, B.

    2010-01-01

    This paper proposes a model of technology acceptance that is specifically developed to test the acceptance of assistive social agents by elderly users. The research in this paper develops and tests an adaptation and theoretical extension of the Unified Theory of Acceptance and Use of Technology

  7. Acceptance and Utilization of Technology (UTAUT) as a Method of Technology Acceptance Model of Mitigation Disaster Website

    Science.gov (United States)

    Siswanto, T.; Shofiati, R.; Hartini, H.

    2018-01-01

    www.mitigasi-bencana.com as a knowledge management website created based on survey results in April-July 2014 in East Java and Central Java provinces, indicates a gap between the expectations and reality that exist in the services provided by the regional disaster management agency. Based on condition analysis, the gaps that occur can be reduced if the community has the understanding and knowledge of adequate disaster mitigation. The problem that arises later is whether the chosen technology solution is appropriate and acceptable to the public? The methodology used in this study using the Technology Acceptance Model development is the Unified Theory of Acceptance and Utilization of Technology (UTAUT). Feedback obtained from respondents KarangTaruna youth SelogedongBantul, www.mitigasi-bencana.com can be accepted by the respondents, but from processed data is obtained only UTAUT hypotheses on the relationship dimension eligible for Social Expectancy on the Attitude toward technology, which means the higher the perception of the Social Expectancy, the higher the perception of the Attitude toward technology. Because www.mitigasi-bencana.com is new socialized so that society still need time to explore content information and knowledge contained therein. To be accepted by user, a knowledge management application must prepare various aspects of Performance Expectancy, Effort Expectancy, Social Factors, Facilitating Conditions and Attitude.

  8. The Analysis of the Relationship Between IT and the organizational Agility of Bojnourd Social Security Hospital

    OpenAIRE

    Saeed Bahramzadeh; Hossein Ali Bahramzadeh; Gorji Mohammad Bagher

    2014-01-01

    In the current research the relationship between the acceptance of IT and organizational agility of Bojnourd Social Security Hospital is analyzed. In this regard, Davis's technology acceptance model (TAM) and organizational agility, based on the model of London Institute study, has been examined. The statistical population is the entire hospital staff of 360. The sample size was determined 186 by using Krejcie and Morgan table. This research is practical in terms of purpose, and in terms of m...

  9. User Acceptance of Long-Term Evolution (LTE) Services: An Application of Extended Technology Acceptance Model

    Science.gov (United States)

    Park, Eunil; Kim, Ki Joon

    2013-01-01

    Purpose: The aim of this paper is to propose an integrated path model in order to explore user acceptance of long-term evolution (LTE) services by examining potential causal relationships between key psychological factors and user intention to use the services. Design/methodology/approach: Online survey data collected from 1,344 users are analysed…

  10. Factors Influencing Adoption of Information Technology Infrastructure Library: Utilizing the Technology Acceptance Model (TAM)

    Science.gov (United States)

    Cox, Din S. Z.

    2013-01-01

    There is a shortage of evidence based research that provides organizations with the necessary information in support of their technology adoption decisions in relation to ITSM technologies. As such, this research study attempted to bridge the gap by offering insight on possible factors that could influence such decisions. An examination of…

  11. Traditional vs. Innovative Uses of Computers among Mathematics Pre-Service Teachers in Serbia

    Science.gov (United States)

    Teo, Timothy; Milutinovic, Verica; Zhou, Mingming; Bankovic, Dragic

    2017-01-01

    This study examined pre-service teachers' intentions to use computers in traditional and innovative teaching practices in primary mathematics classrooms. It extended the technology acceptance model (TAM) by adding as external variables pre-service teachers' experience with computers and their technological pedagogical content knowledge (TPCK).…

  12. Estudio exploratorio del impacto de la red social en el nivel individual de aceptación de sistemas empresariales Exploratory study of the impact of the social network at the individual level of acceptance of enterprise systems

    Directory of Open Access Journals (Sweden)

    Patricio Ramírez Correa

    2012-04-01

    Full Text Available El presente trabajo tiene por propósito explorar el impacto de la red social en el uso de sistemas empresariales. Utilizando un modelo de aceptación de tecnologías de información con base en TAM, se explora la red de relaciones sociales asociadas al uso efectivo del sistema empresarial. El modelo de investigación incorporó las siguientes variables: normas sociales, ansiedad computacional, demostrabilidad de los resultados, relevancia para el trabajo, percepción de utilidad, percepción de facilidad de uso, intención de uso y uso del sistema. En una muestra de 90 individuos se realizó un análisis SEM-PLS del modelo que incluyó los valores asociados a medidas de centralidad y densidad de la red. El modelo de investigación y los resultados iniciales de este análisis se exponen en este artículo.The purpose of this paper is to explore the impact of the social network in using enterprise systems. Using a model of information technology acceptance based on TAM, this paper explores the social network associated with the effective use of the enterprise system. The research model incorporated the following variables: social norms, computer anxiety, results demonstrability, job relevance, perceived usefulness, perceived ease of use, behavior intention to use and use of the system. In a sample of 90 individuals, the SEM-PLS analysis of the model included the values associated with measures of centrality and network density. The research model and initial results of this analysis are presented in this article.

  13. Análisis del efecto moderador de la edad en la aceptación de sistemas e-learning LMS / An analysis of the moderating effects of age in the acceptance of Learning Management Systems

    Directory of Open Access Journals (Sweden)

    Óscar Lorenzo DUEÑAS-RUGNON

    2012-03-01

    Full Text Available El presente estudio analiza las intenciones de los usuarios acerca del uso de sistemas de tele-enseñanza LMS (Learning Management Systems, basándose en un modelo que integra el Modelo de Aceptación Tecnológica (TAM, Technology Acceptance Model, la Teoría del Comportamiento Percibido (TPB, Theory of Planned Behavior y la Teoría Unificada de la Aceptación y Uso de la Tecnología (UTAUT, Unified Theory of Acceptance and Use of Technology, tomando la edad como variable moderadora.Así, este artículo estudia la influencia de la intención conductual, la actitud hacia el uso, la facilidad de uso percibida, la utilidad percibida, la norma subjetiva y la influencia social en la intención de utilizar sistemas e-learning LMS. Como antecedentes de estos factores de influencia se plantean las características del sistema y del usuario.El resultado de la revisión teórica es un modelo unificado que ha sido validado con datos recogidos de 94 estudiantes a través de un cuestionario en línea. Estos datos han sido analizados utilizando la técnica de mínimos cuadrados parciales, y los principales resultados confirman la relevancia predictiva del modelo para usuarios de entre 26 y 35 años y de entre 36 y 45 años.   This study analyses students’ intentions to use e-learning management systems based on an inventory which integrates the Technology Adoption Model (TAM, the Theory of Planned Behavior (TPB and the Unified Theory of Acceptance and Use of Technology (UTAUT, with the difference of age as moderating variable. In particular, the most relevant learning management systems (LMS adoption models have been reviewed from literature.Thus, this paper studies the influence of behavioral intention, attitude toward use, perceived usefulness, perceived ease of use, subjective norms and social influence in the intention to use e-learning management systems. User and system characteristics have been proposed as antecedents of the former factors

  14. Family support and acceptance, gay male identity formation, and psychological adjustment: a path model.

    Science.gov (United States)

    Elizur, Y; Ziv, M

    2001-01-01

    While heterosexist family undermining has been demonstrated to be a developmental risk factor in the life of persons with same-gender orientation, the issue of protective family factors is both controversial and relatively neglected. In this study of Israeli gay males (N = 114), we focused on the interrelations of family support, family acceptance and family knowledge of gay orientation, and gay male identity formation, and their effects on mental health and self-esteem. A path model was proposed based on the hypotheses that family support, family acceptance, family knowledge, and gay identity formation have an impact on psychological adjustment, and that family support has an effect on gay identity formation that is mediated by family acceptance. The assessment of gay identity formation was based on an established stage model that was streamlined for cross-cultural practice by defining three basic processes of same-gender identity formation: self-definition, self-acceptance, and disclosure (Elizur & Mintzer, 2001). The testing of our conceptual path model demonstrated an excellent fit with the data. An alternative model that hypothesized effects of gay male identity on family acceptance and family knowledge did not fit the data. Interpreting these results, we propose that the main effect of family support/acceptance on gay identity is related to the process of disclosure, and that both general family support and family acceptance of same-gender orientation play a significant role in the psychological adjustment of gay men.

  15. FACTORS INFLUENCING MOBILE-LEARNING ADOPTION INTENTION: AN EMPIRICAL INVESTIGATION IN HIGH EDUCATION

    OpenAIRE

    Ngo Tan Vu Khanh; Gwangyong Gim

    2014-01-01

    This study investigates the use of mobile phones and tablets for learning purposes among university students in Vietnam. For this purpose, the research is based on relevant technology acceptance literature and the Technology Acceptance Model (TAM) is proposed to analyze the adoption of mobile devices and smart phones by Vietnam students for accessing course materials, searching the web for information related to their discipline, sharing knowledge, conducting assignments etc. Employing struct...

  16. Understanding technology adoption through individual and context characteristics: the case of HDTV

    NARCIS (Netherlands)

    Baaren, Eva; van de Wijngaert, Lidwien; Huizer, E.

    2011-01-01

    Technology adoption research has a tradition of using and improving Davis' (1989) “Technology Acceptance Model” (TAM) and extended versions of it. This article suggests a break with this tradition by showing that the TAM is limited in its understanding of technology adoption. Two alternative

  17. Predicting customer’s intentions to use internet banking: the role of technology acceptance model (TAM in e-banking

    Directory of Open Access Journals (Sweden)

    Samar Rahi

    2017-11-01

    Full Text Available Information and communication technology (ICT developments and trends in recent years have had great impacts on banking sector worldwide. Therefore, the disruptive innovative technology has accelerated changes in the way of banking business. The purpose of this paper is to explore the factors that influence on Pakistani customer’s intentions to adopt internet banking. The sample used in this empirical study includes 265 responses of internet banking users collected through structured questionnaire. For statistical analysis, structural equation model (SEM approach was used. The present study suggests that internet banking use increases as long as customer perceives it as useful tool. Findings confirmed that perceived usefulness, perceived ease of use and attitude were the key constructs for promoting internet banking usage in Pakistan. Furthermore, the importance performance matrix analysis has shown that attitude was the most important factor. Thus, banks can focus on cultivation of positive attitudinal beliefs about internet banking among prospect cus-tomers.

  18. A PC microsimulation of a gap acceptance model for turning left at a T-junction

    NARCIS (Netherlands)

    Schaap, Nina; Dijck, T.; van Arem, Bart; Morsink, Peter L.J.

    2009-01-01

    Vehicles are controlled by sub-behavioral models in a microsimulation model, this includes the gap acceptance model where the decision about how to cross a junction is made. The critical gap in these models must serve as a threshold value to accept or reject the space between two successive vehicles

  19. Post Advanced Technology Implementation Effects on School Psychologist Job Performance

    Science.gov (United States)

    Hobson, Rana Dirice

    2017-01-01

    The technology acceptance model (TAM) has been widely used to assess technology adoption in business, education, and health care. The New York City Department of Education (NYCDOE) launched a web-based Individualized Educational Program (IEP) system for school psychologists to use in conducting evaluations and reviews. This quantitative study…

  20. An Assessment of E-Training Effectiveness in Multinational Companies in Malaysia

    Science.gov (United States)

    Ramayah, Thurasamy; Ahmad, Noor Hazlina; Hong, Tan Say

    2012-01-01

    E-training has developed into a revolutionary way of learning in Malaysian organizations due to rapid growth in information technology infrastructure. The present study endeavors to determine the critical factors that influence e-training effectiveness in multinational companies (MNCs) in Malaysia. By integrating Technology Acceptance Model (TAM),…

  1. The technology acceptance model: predicting nurses' intention to use telemedicine technology (eICU).

    Science.gov (United States)

    Kowitlawakul, Yanika

    2011-07-01

    The purposes of this study were to determine factors and predictors that influence nurses' intention to use the eICU technology, to examine the applicability of the Technology Acceptance Model in explaining nurses' intention to use the eICU technology in healthcare settings, and to provide psychometric evidence of the measurement scales used in the study. The study involved 117 participants from two healthcare systems. The Telemedicine Technology Acceptance Model was developed based on the original Technology Acceptance Model that was initially developed by Fred Davis in 1986. The eICU Acceptance Survey was used as an instrument for the study. Content validity was examined, and the reliability of the instrument was tested. The results show that perceived usefulness is the most influential factor that influences nurses' intention to use the eICU technology. The principal factors that influence perceived usefulness are perceived ease of use, support from physicians, and years working in the hospital. The model fit was reasonably adequate and able to explain 58% of the variance (R = 0.58) in intention to use the eICU technology with the nursing sample.

  2. An evaluation model for indoor environmental quality (IEQ) acceptance in residential buildings

    International Nuclear Information System (INIS)

    Lai, A.C.K.; Mui, K.W.; Wong, L.T.; Law, L.Y.

    2009-01-01

    The indoor environmental quality (IEQ) in residential buildings is examined from the prospect of an occupant's acceptance in four aspects: thermal comfort, indoor air quality, noise level and illumination level. Based on the evaluations by 125 occupants living in 32 typical residential apartments in Hong Kong, this study proposes empirical expressions to approximate the overall IEQ acceptance with respect to four contributors, namely operative temperature, carbon dioxide concentration, equivalent noise level and illumination level, via a multivariate logistic regression model. A range of IEQ acceptances for regular residential conditions is determined and the dependence of the predicted overall IEQ acceptance on the variations of the contributors is discussed. The proposed overall IEQ acceptance can be used as a quantitative assessment criterion for similar residential environments where an occupant's evaluation is expected. (author)

  3. Individual acceptance of the biogas innovation: A structural equation model

    International Nuclear Information System (INIS)

    Emmann, Carsten H.; Arens, Ludwig; Theuvsen, Ludwig

    2013-01-01

    The rapid spread of biogas production in Germany has resulted in an increased public debate over this new business branch. Today the production of biogas is much more controversially debated than several years ago. At the same time it could be proven that even among farmers themselves the acceptance of biogas production in some regions is somewhat dampened due to accompanying “collateral damages”. Therefore, the goal of this paper is to identify relevant influencing factors that determine the acceptance of the innovation “biogas” among farmers by applying a causal analysis. Initial results among the five investigated determinants show that not only an individual attitude toward biogas but also the farmers' personal innovativeness strongly and significantly influences an individual's acceptance of the innovation “biogas”. -- Highlights: •Strong expansion of biogas production based on renewable resources in Germany since 2004. •Low acceptance of biogas production in some regions. •Identification of influencing factors that determine the individual acceptance of the biogas innovation among German farmers. •Compared to existing studies, personal innovativeness was taken into account in the causal model. •Results are important for the further expansion of biogas production in Germany as well as in other countries

  4. Investigating the potential of e-Learning in healthcare postgraduate curricula: a structural equation model.

    Science.gov (United States)

    Katharaki, Maria; Daskalakis, Stelios; Mantas, John

    2010-01-01

    The objective of this paper is to assess the future adaptability of e-Learning platforms within postgraduate modules. An ongoing empirical assessment was conducted amongst postgraduate students, based on the Technology Acceptance Model (TAM). The current paper presents the outcomes from the second phase of a survey, involving fifty six participants. Data analysis was performed using a structural equation model, based on partial least squares. Results highlighted the very strong effect of perceived usefulness and perceived ease of use to attitude towards using e-Learning platforms. Consequently, attitude towards use proved to be a very strong predictor of behavioral intention. Perceived usefulness, on the contrary, did not prove to have an effect to behavioral intention. Implications on the potential of using e-Learning platforms are discussed along with limitations and future directions of the study.

  5. Applying the technology acceptance model to explore public health nurses' intentions towards web-based learning: a cross-sectional questionnaire survey.

    Science.gov (United States)

    Chen, I Ju; Yang, Kuei-Feng; Tang, Fu-In; Huang, Chun-Hsia; Yu, Shu

    2008-06-01

    In the era of the knowledge economy, public health nurses (PHNs) need to update their knowledge to ensure quality of care. In pre-implementation stage, policy makers and educators should understand PHNs' behavioural intentions (BI) toward web-based learning because it is the most important determinant of actual behaviour. To understand PHNs' BI toward web-based learning and further to identify the factors influencing PHNs' BI based on the technology acceptance model (TAM) in pre-implementation stage. A nationwide-based cross-sectional research design was used in this study. Three hundred and sixty-nine health centres in Taiwan. A randomly selected sample, 202 PHNs participated in this study. Data were collected by mailing in a questionnaire. The majority of PHNs (91.6%, n=185) showed an affirmative BI toward web-based learning. PHNs rated moderate values of perceived usefulness (U), perceived ease of use (EOU) and attitude toward web-based learning (A). Multiple regression analyses indicated that only U revealed a significantly direct influence on BI. U and EOU had significantly direct relationships with A; however, no significant relationship existed between A and BI. Additionally, EOU and an individual's computer competence revealed significant relationships with U; Internet access at the workplace revealed a significant relationship with EOU. In the pre-implementation stage, PHNs perceived a high likelihood of adopting web-based learning as their way of continuing education. In pre-implementation stage, perceived usefulness is the most important factor for BI instead of the attitude. Perceived EOU, an individual's computer competency, and Internet access at workplaces revealed indirect effects on BI. Therefore, increasing U, EOU, computer competence, and Internet access at workplace will be helpful in increasing PHNs' BI. Moreover, we suggest that future studies should focus on clarifying problems in different stages of implementation to build a more complete

  6. Applying the Technology Acceptance Model (TAM) to Explore the Effects of a Course Management System (CMS)-Assisted EFL Writing Instruction

    Science.gov (United States)

    Tsai, Yea-Ru

    2015-01-01

    This study illustrates a teaching model that utilizes a Blackboard (Bb) course management system (CMS) to support English writing instruction. It was implemented in a blended English research paper (RP) writing course, with specific learning resources and activities offered inside and outside the Bb CMS. A quasi-experimental study in which the…

  7. Modeling of a Parabolic Trough Solar Field for Acceptance Testing: A Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, M. J.; Mehos, M. S.; Kearney, D. W.; McMahan, A. C.

    2011-01-01

    As deployment of parabolic trough concentrating solar power (CSP) systems ramps up, the need for reliable and robust performance acceptance test guidelines for the solar field is also amplified. Project owners and/or EPC contractors often require extensive solar field performance testing as part of the plant commissioning process in order to ensure that actual solar field performance satisfies both technical specifications and performance guaranties between the involved parties. Performance test code work is currently underway at the National Renewable Energy Laboratory (NREL) in collaboration with the SolarPACES Task-I activity, and within the ASME PTC-52 committee. One important aspect of acceptance testing is the selection of a robust technology performance model. NREL1 has developed a detailed parabolic trough performance model within the SAM software tool. This model is capable of predicting solar field, sub-system, and component performance. It has further been modified for this work to support calculation at subhourly time steps. This paper presents the methodology and results of a case study comparing actual performance data for a parabolic trough solar field to the predicted results using the modified SAM trough model. Due to data limitations, the methodology is applied to a single collector loop, though it applies to larger subfields and entire solar fields. Special consideration is provided for the model formulation, improvements to the model formulation based on comparison with the collected data, and uncertainty associated with the measured data. Additionally, this paper identifies modeling considerations that are of particular importance in the solar field acceptance testing process and uses the model to provide preliminary recommendations regarding acceptable steady-state testing conditions at the single-loop level.

  8. A Preliminary Introduction to the OTAM: Exploring Users’ Perceptions of their on-going Interaction with Adopted Technologies

    Directory of Open Access Journals (Sweden)

    Shirlee-ann Knight

    2011-03-01

    Full Text Available ABSTRACT A common criticism directed at Davis’ (1986; 1989 Technology Acceptance Model relates to its failure to adequately frame the “experienced” user’s ongoing adoption and exploitation of information technologies. Given the pervasive nature of technology into individual users’ ongoing, everyday communication and information interactions, along with the “new adopter” becoming an increasingly rare entity, the TAM is in danger of becoming a somewhat obsolete framework for investigating user-technology interaction. Presented is a critical analysis of the development and current state of the TAM, followed by a proposed addition to the existing Perceived Usefulness (PU and Perceived Ease of Use (PEoU TAM constructs. The paper contends that the inclusion of a Perception of Interaction (PoI construct allows researchers to develop an investigative framework which facilitates an exploration of users’ ongoing perceptions of the predictability of their technology interaction processes.

  9. Using the Web as a Strategic Resource: An Applied Classroom Exercise.

    Science.gov (United States)

    Wright, Kathleen M.; Granger, Mary J.

    This paper reports the findings of an experiment designed to test extensions of the Technology Acceptance Model (TAM) within the context of using the World Wide Web to gather and analyze financial information. The proposed extensions are three-fold. Based on prior research, cognitive absorption variables are posited as predeterminants of ease of…

  10. Understanding E-Learning Adoption in Brazil: Major Determinants and Gender Effects

    Science.gov (United States)

    Okazaki, Shintaro; dos Santos, Luiz Miguel Renda

    2012-01-01

    The objective of this study is to examine factors influencing e-learning adoption and the moderating role of gender. This study extends the technology acceptance model (TAM) by adding attitude and social interaction. The new construct of social interaction is applied to the South American context. Gender effects on e-learning adoption from…

  11. Why Don't All Maths Teachers Use Dynamic Geometry Software in Their Classrooms?

    Science.gov (United States)

    Stols, Gerrit; Kriek, Jeanne

    2011-01-01

    In this exploratory study, we sought to examine the influence of mathematics teachers' beliefs on their intended and actual usage of dynamic mathematics software in their classrooms. The theory of planned behaviour (TPB), the technology acceptance model (TAM) and the innovation diffusion theory (IDT) were used to examine the influence of teachers'…

  12. Research Article Special Issue

    African Journals Online (AJOL)

    pc

    2018-05-01

    May 1, 2018 ... rldwide age, web based learning has turned out to be one of the princ ... research the path analysis of the model of technology acceptance (TAM), while the second ... gain MOOC certificate [16], the effect of learning style at individual level on the .... However, the completed returns were 200 questionnaires.

  13. Diversity of Andean amphibians of the Tamá National Natural Park in Colombia: a survey for the presence of Batrachochytrium dendrobatidis

    Energy Technology Data Exchange (ETDEWEB)

    Acevedo, A.A.; Franco, R.; Carrero, D.A.

    2016-07-01

    Changes in diversity and possible decreases in populations of amphibians have not yet been determined in many areas in the Andes. This study aimed to develop an inventory of the biodiversity of amphibians in the Andean areas of the Tamá National Natural Park (Tamá NNP) and to evaluate the patterns of infection by Batrachochytrium dendrobatidis (Bd) in preserved and degraded areas. We performed samplings focused on three habitats (forest, open areas and streams) in four localities from 2,000 to 3,200 m in altitude. Fourteen species were recorded, 12 of which were positive for Bd. A total of 541 individuals were diagnosed and 100 were positive. Our analyses showed that preserved areas play an important role in keeping many individuals Bd–free as compared to those in degraded areas. This was the first study to evaluate diversity and infection by Bd in the northeast region of Colombia. Our findings may help improve our knowledge of the diversity of amphibian species in the area and facilitate the implementation of action plans to mitigate the causes associated with the decrease in amphibian populations. (Author)

  14. Patients’ Acceptance of Smartphone Health Technology for Chronic Disease Management: A Theoretical Model and Empirical Test

    Science.gov (United States)

    Dou, Kaili; Yu, Ping; Liu, Fang; Guan, YingPing; Li, Zhenye; Ji, Yumeng; Du, Ningkai; Lu, Xudong; Duan, Huilong

    2017-01-01

    Background Chronic disease patients often face multiple challenges from difficult comorbidities. Smartphone health technology can be used to help them manage their conditions only if they accept and use the technology. Objective The aim of this study was to develop and test a theoretical model to predict and explain the factors influencing patients’ acceptance of smartphone health technology for chronic disease management. Methods Multiple theories and factors that may influence patients’ acceptance of smartphone health technology have been reviewed. A hybrid theoretical model was built based on the technology acceptance model, dual-factor model, health belief model, and the factors identified from interviews that might influence patients’ acceptance of smartphone health technology for chronic disease management. Data were collected from patient questionnaire surveys and computer log records about 157 hypertensive patients’ actual use of a smartphone health app. The partial least square method was used to test the theoretical model. Results The model accounted for .412 of the variance in patients’ intention to adopt the smartphone health technology. Intention to use accounted for .111 of the variance in actual use and had a significant weak relationship with the latter. Perceived ease of use was affected by patients’ smartphone usage experience, relationship with doctor, and self-efficacy. Although without a significant effect on intention to use, perceived ease of use had a significant positive influence on perceived usefulness. Relationship with doctor and perceived health threat had significant positive effects on perceived usefulness, countering the negative influence of resistance to change. Perceived usefulness, perceived health threat, and resistance to change significantly predicted patients’ intentions to use the technology. Age and gender had no significant influence on patients’ acceptance of smartphone technology. The study also

  15. ICT and OTs: a model of information and communication technology acceptance and utilisation by occupational therapists.

    Science.gov (United States)

    Schaper, Louise K; Pervan, Graham P

    2007-06-01

    There is evidence to suggest that health professionals are reluctant to accept and utilise information and communication technologies (ICT) and concern is growing within health informatics research that this is contributing to the lag in adoption and utilisation of ICT across the health sector. Technology acceptance research within the field of information systems has been limited in its application to health and there is a concurrent need to develop and gain empirical support for models of technology acceptance within health and to examine acceptance and utilisation issues amongst health professionals to improve the success of information system implementation in this arena. This paper outlines a project that examines ICT acceptance and utilisation by Australian occupational therapists. It describes the theoretical basis behind the development of a research model and the methodology being employed to empirically validate the model using substantial quantitative, qualitative and longitudinal data. Preliminary results from Phase II of the study are presented. The theoretical significance of this work is that it uses a thoroughly constructed research model, with potentially the largest sample size ever tested, to extend technology acceptance research into the health sector.

  16. Capacity Prediction Model Based on Limited Priority Gap-Acceptance Theory at Multilane Roundabouts

    Directory of Open Access Journals (Sweden)

    Zhaowei Qu

    2014-01-01

    Full Text Available Capacity is an important design parameter for roundabouts, and it is the premise of computing their delay and queue. Roundabout capacity has been studied for decades, and empirical regression model and gap-acceptance model are the two main methods to predict it. Based on gap-acceptance theory, by considering the effect of limited priority, especially the relationship between limited priority factor and critical gap, a modified model was built to predict the roundabout capacity. We then compare the results between Raff’s method and maximum likelihood estimation (MLE method, and the MLE method was used to predict the critical gaps. Finally, the predicted capacities from different models were compared, with the observed capacity by field surveys, which verifies the performance of the proposed model.

  17. Pedagogical Factors Affecting Integration of Computers in Mathematics Instruction in Secondary Schools in Kenya

    Science.gov (United States)

    Wanjala, Martin M. S.; Aurah, Catherine M.; Symon, Koros C.

    2015-01-01

    The paper reports findings of a study which sought to examine the pedagogical factors that affect the integration of computers in mathematics instruction as perceived by teachers in secondary schools in Kenya. This study was based on the Technology Acceptance Model (TAM). A descriptive survey design was used for this study. Stratified and simple…

  18. Technological Development and Its Impact on Student Reception of a Campus Radio

    Science.gov (United States)

    Mohamed, Shafizan; Wok, Saodah; Lahabou, Mahaman

    2018-01-01

    In 2011, a study was conducted to look at students' reception of IIUM.FM, a newly launched online campus radio. Using the Technological Acceptance Model (TAM), the study found that factors such as perceived ease of use, perceived usefulness, and attitude highly influenced audience reception of the online radio. In 2016, a corresponding study,…

  19. Acceptance on Mobile Learning via SMS: A Rasch Model Analysis

    Directory of Open Access Journals (Sweden)

    Issham Ismail

    2010-04-01

    Full Text Available This study investigated whether mobile learning via Short Message Service (SMS-learning is accepted by the students enrolled in the distance learning academic programme in the Universiti Sains Malaysia. This study explored the impact of perceived usefulness, perceived ease of use and usability of the system to their acceptability. The survey was constructed using a questionnaire consisting of statements regarding the participants’ demographics, experiences in and perception of using mobile learning via SMS, involving 105 students from management and sciences disciplines. The Rasch Model Analysis was used for measurement correspond to a 5 point Likert. Results indicated that the usability of the system contributed to be effectiveness in assisting the students with their study. Respondents agree that SMS-learning is easy, effective and useful to help them study. However, the results found that there has been a problem in mobile learning that less interaction with lecturers. It implies that the acceptability of students to this mode on communication and interaction is highly endorsed.

  20. Patients' Acceptance of Smartphone Health Technology for Chronic Disease Management: A Theoretical Model and Empirical Test.

    Science.gov (United States)

    Dou, Kaili; Yu, Ping; Deng, Ning; Liu, Fang; Guan, YingPing; Li, Zhenye; Ji, Yumeng; Du, Ningkai; Lu, Xudong; Duan, Huilong

    2017-12-06

    Chronic disease patients often face multiple challenges from difficult comorbidities. Smartphone health technology can be used to help them manage their conditions only if they accept and use the technology. The aim of this study was to develop and test a theoretical model to predict and explain the factors influencing patients' acceptance of smartphone health technology for chronic disease management. Multiple theories and factors that may influence patients' acceptance of smartphone health technology have been reviewed. A hybrid theoretical model was built based on the technology acceptance model, dual-factor model, health belief model, and the factors identified from interviews that might influence patients' acceptance of smartphone health technology for chronic disease management. Data were collected from patient questionnaire surveys and computer log records about 157 hypertensive patients' actual use of a smartphone health app. The partial least square method was used to test the theoretical model. The model accounted for .412 of the variance in patients' intention to adopt the smartphone health technology. Intention to use accounted for .111 of the variance in actual use and had a significant weak relationship with the latter. Perceived ease of use was affected by patients' smartphone usage experience, relationship with doctor, and self-efficacy. Although without a significant effect on intention to use, perceived ease of use had a significant positive influence on perceived usefulness. Relationship with doctor and perceived health threat had significant positive effects on perceived usefulness, countering the negative influence of resistance to change. Perceived usefulness, perceived health threat, and resistance to change significantly predicted patients' intentions to use the technology. Age and gender had no significant influence on patients' acceptance of smartphone technology. The study also confirmed the positive relationship between intention to use

  1. Exploring the role of ethnic media and the community readiness to combat stigma attached to mental illness among Vietnamese immigrants: the pilot project Tam An (Inner Peace in Vietnamese).

    Science.gov (United States)

    Han, Meekyung; Cao, Lien; Anton, Karen

    2015-01-01

    Vietnamese Americans are at high risk for developing mental health disorders due to multiple risk factors such as trauma and acculturative stress. However, the utilization of mental health services has been low. The pilot project Tam An was implemented to raise mental health awareness by engaging community resources in the Vietnamese population. Informed by the Community Readiness Model and through local ethnic media sources, messages to destigmatize mental health and promote the willingness to initiate mental health treatment were presented. Using an exploratory perspective, findings from focus group data suggest that the project improved the community's stage of readiness.

  2. Understanding consumers’ acceptance of mobile payments : a theoretical model and empirical validation

    OpenAIRE

    Chen, Jiajun

    2007-01-01

    This research investigates consumer acceptance of mobile payments. Mobile payments offer an alternative payment method for consumers, and allow consumers to make point-of-sales payments through mobile devices, such as mobile phones and Personal Digital Assistants (PDAs). It aims to present a better understanding of mobile payments, developing a consumer acceptance model for mobile payments. Moreover, it offers a reference and a source of literature for the industry and academic researchers in...

  3. Cross-national comparisons of college students' attitudes toward diet/fitness apps on smartphones.

    Science.gov (United States)

    Cho, Jaehee; Lee, H Erin; Quinlan, Margaret

    2017-10-01

    Based on the technology acceptance model (TAM), we explored the nationally-bounded roles of four predictors (subjective norms, entertainment, recordability, and networkability) in determining the TAM variables of perceived usefulness (PU), perceived ease of use (PEOU), and behavioral intention (BI) to use diet/fitness apps on smartphones. College students in the US and South Korea were invited to participate in a survey. We obtained 508 questionnaires (304 from the US and 204 from Korea). Data were analyzed mainly through path analysis. The four factors positively predicted the PU and PEOU of diet/fitness apps. While the effects of the predictors on the three TAM components were generally stronger among the US students than Korean students, the effect of subjective norms on the BI of diet/fitness apps was weaker among Korean students. Findings from the cross-national comparisons were helpful for thoroughly understanding the contextualized mechanisms involved in the adoption of diet/fitness apps.

  4. Factors Influencing the Use of Mobile Technologies in a University Environment: A Case from Latin America

    Science.gov (United States)

    Yamakawa, Peter; Delgado, Carlos; Díaz, Esperanza; Garayar, Erik; Laguna, Hedda

    2013-01-01

    The use of mobile technologies in higher education seem to be lagging those in other service sectors, which have been quick to utilize the advantages that mobile communications have to offer. Based on the Technology Acceptance Model (TAM), this study analyzes the range factors and the level of influence on undergraduate intention to use a proposed…

  5. The Effect of a Learning Environment Using an Electronic Health Record (EHR) on Undergraduate Nursing Students' Behaviorial Intention to Use an EHR

    Science.gov (United States)

    Foley, Shawn

    2011-01-01

    The purpose of this study was to explore the effect of a learning environment using an Electronic Health Record (EHR) on undergraduate nursing students' behavioral intention (BI) to use an EHR. BI is defined by Davis (1989) in the Technology Acceptance Model (TAM) as the degree to which a person has formulated conscious plans to perform or not…

  6. Modeling the impact of a carbon tax: A trial analysis for Washington State

    International Nuclear Information System (INIS)

    Mori, Keibun

    2012-01-01

    In recent years, energy policy makers have proposed a carbon tax as an economy-wide policy tool to curb greenhouse gas (GHG) emissions. The quantification of its impact on GHG emissions has relied on an energy-economy model, whose complexity often makes it difficult to comprehend how it simulates the interaction of a carbon tax and energy demand. This study therefore aims at developing an alternative model called the Carbon Tax Analysis Model (C-TAM). The elasticity-based approach used in C-TAM is less sophisticated than an equilibrium-based approach used in an energy-economy model, but C-TAM is designed to maximize its predictive capabilities by using a wide range of elasticities for each sector and fuel use, accounting for likely changes in fuel mix for electricity generation, and addressing the model's sensitivity to elasticity estimates with Monte Carlo simulation. The trial analysis in this study evaluates a potential carbon tax in Washington State, suggesting a carbon tax at US$30 per metric ton of CO 2 (tCO 2 ) lowers GHG emissions by 8.4% from the business-as-usual (BAU) scenario in 2035. The study concludes that C-TAM can provide meaningful policy implications by forecasting detailed impact on revenues and energy demand for each sector and fuel use. - Highlights: ► An elasticity-based model is developed to forecast the impact of a carbon tax. ► This model can show detailed impacts on each sector and fuel use. ► Extensive literature review and sensitivity analyses cover the model's weakness. ► A carbon tax is effective in curbing greenhouse gas emissions in Washington State. ► A carbon tax is however more effective if implemented nationwide.

  7. An Investigation of Employees' Use of E-Learning Systems: Applying the Technology Acceptance Model

    Science.gov (United States)

    Lee, Yi-Hsuan; Hsieh, Yi-Chuan; Chen, Yen-Hsun

    2013-01-01

    The purpose of this study is to apply the technology acceptance model to examine the employees' attitudes and acceptance of electronic learning (e-learning) systems in organisations. This study examines four factors (organisational support, computer self-efficacy, prior experience and task equivocality) that are believed to influence employees'…

  8. Model of acceptance of a new type of beverage: application to natural sparkling red wine

    OpenAIRE

    Cristina Olarte; Jorge Pelegrín; Eva Reinares

    2017-01-01

    Wine is a traditional beverage with a saturated market, in which consumers are open to innovation. In this context, an innovative experience was launched to create a new natural sparkling red wine with a view to diversifying production and studying its acceptance. This paper uses an original acceptance model for new foods called the Cognitive-Affective-Normative (CAN) model. The model was tested on a sample of 500 Spanish consumers in a real-world test context and explains 64.1% of the intent...

  9. Nature preservation acceptance model applied to tanker oil spill simulations

    DEFF Research Database (Denmark)

    Friis-Hansen, Peter; Ditlevsen, Ove Dalager

    2003-01-01

    is exemplified by a study of oil spills due to simulated tanker collisions in the Danish straits. It is found that the distribution of the oil spill volume per spill is well represented by an exponential distribution both in Oeresund and in Great Belt. When applied in the Poisson model, a risk profile reasonably...... acceptance criterion for the pollution of the environment. This NPWI acceptance criterion is applied to the oil spill example....... be defined in a similar way as the so-called Life Quality Index defined by Nathwani et al [Nathwani JS, Lind NC, Padey MD. Affordable safety by choice: the life quality method. Institute for Risk Research, University of Waterloo; Waterloo (Ontario, Canada):1997], and can be used to quantify the risk...

  10. Nurses' perceptions, acceptance, and use of a novel in-room pediatric ICU technology: testing an expanded technology acceptance model.

    Science.gov (United States)

    Holden, Richard J; Asan, Onur; Wozniak, Erica M; Flynn, Kathryn E; Scanlon, Matthew C

    2016-11-15

    The value of health information technology (IT) ultimately depends on end users accepting and appropriately using it for patient care. This study examined pediatric intensive care unit nurses' perceptions, acceptance, and use of a novel health IT, the Large Customizable Interactive Monitor. An expanded technology acceptance model was tested by applying stepwise linear regression to data from a standardized survey of 167 nurses. Nurses reported low-moderate ratings of the novel IT's ease of use and low to very low ratings of usefulness, social influence, and training. Perceived ease of use, usefulness for patient/family involvement, and usefulness for care delivery were associated with system satisfaction (R 2  = 70%). Perceived usefulness for care delivery and patient/family social influence were associated with intention to use the system (R 2  = 65%). Satisfaction and intention were associated with actual system use (R 2  = 51%). The findings have implications for research, design, implementation, and policies for nursing informatics, particularly novel nursing IT. Several changes are recommended to improve the design and implementation of the studied IT.

  11. Diversity of resource use and property rights in Tam Giang Lagoon, Vietnam

    Directory of Open Access Journals (Sweden)

    Ta Thi Thanh Huong

    2011-02-01

    Full Text Available Since the early 1990s, aquaculture has become the most important livelihood activity in Tam Giang Lagoon, Vietnam. The aquaculture boom has reduced the available water area for mobile gear fishers, polarized different user-groups, created resource conflicts, and increased pressures on the lagoon systems. Aquaculture in the lagoon is governed by both customary and legal rights. The objective of this paper is to explore the diversity of resource use and the complexity of property rights in one of the villages located in the lagoon. The paper emphasizes the linkages between changes in commons institutions and changes in resource use and property rights. First, the political and socio-economic changes in Vietnam are examined as well as how they have influenced traditional commons institutions and lagoon resource management in the village. Second, the linkages between common institutions and the diversity of property rights are analyzed. Particular attention is given to the analysis of different types of resource use associated with "bundle of rights" and the diversity of property rights regimes in the village.

  12. Factors affecting smartphone adoption for accessing information in medical settings.

    Science.gov (United States)

    Tahamtan, Iman; Pajouhanfar, Sara; Sedghi, Shahram; Azad, Mohsen; Roudbari, Masoud

    2017-06-01

    This study aimed to acquire knowledge about the factors affecting smartphone adoption for accessing information in medical settings in Iranian Hospitals. A qualitative and quantitative approach was used to conduct this study. Semi-structured interviews were conducted with 21 medical residents and interns in 2013 to identify determinant factors for smartphone adoption. Afterwards, nine relationships were hypothesised. We developed a questionnaire to test these hypotheses and to evaluate the importance of each factor. Structural equation modelling was used to analyse the causal relations between model parameters and to accurately identify determinant factors. Eight factors were identified in the qualitative phase of the study, including perceived usefulness, perceived ease of use, training, internal environment, personal experience, social impacts, observability and job related characteristics. Among the studied factors, perceived usefulness, personal experience and job related characteristics were significantly associated with attitude to use a smartphone which accounted for 64% of the variance in attitude. Perceived usefulness had the strongest impact on attitude to use a smartphone. The factors that emerged from interviews were consistent with the Technology Acceptance Model (TAM) and some previous studies. TAM is a reliable model for understanding the factors of smartphone acceptance in medical settings. © 2017 Health Libraries Group.

  13. Looking under the Bonnet: Factors Affecting Student Adoption of E-Learning Systems in Jordan

    Directory of Open Access Journals (Sweden)

    Muneer Mahmood Abbad, David Morris, Carmel de Nahlik

    2009-04-01

    Full Text Available The primary questions addressed in this paper are the following: what are the factors that affect students’ adoption of an e-learning system and what are the relationships among these factors?This paper investigates and identifies some of the major factors affecting students’ adoption of an e-learning system in a university in Jordan. E-learning adoption is approached from the information systems acceptance point of view. This suggests that a prior condition for learning effectively using e-learning systems is that students must actually use them. Thus, a greater knowledge of the factors that affect IT adoption and their interrelationships is a pre-cursor to a better understanding of student acceptance of e-learning systems. In turn, this will help and guide those who develop, implement, and deliver e-learning systems.In this study, an extended version of the Technology Acceptance Model (TAM was developed to investigate the underlying factors that influence students’ decisions to use an e-learning system. The TAM was populated using data gathered from a survey of 486 undergraduate students using the Moodle based e-learning system at the Arab Open University. The model was estimated using Structural Equation Modelling (SEM. A path model was developed to analyze the relationships between the factors to explain students’ adoption of the e-learning system. Whilst findings support existing literature about prior experience affecting perceptions, they also point to surprising group effects, which may merit future exploration.

  14. Does screen size matter for smartphones? Utilitarian and hedonic effects of screen size on smartphone adoption.

    Science.gov (United States)

    Kim, Ki Joon; Sundar, S Shyam

    2014-07-01

    This study explores the psychological effects of screen size on smartphone adoption by proposing an extended Technology Acceptance Model (TAM) that integrates an empirical comparison between large and small screens with perceived control, affective quality, and the original TAM constructs. A structural equation modeling analysis was conducted on data collected from a between-subjects experiment (N=130) in which users performed a web-based task on a smartphone with either a large (5.3 inches) or a small (3.7 inches) screen. Results show that a large screen, compared to a small screen, is likely to lead to higher smartphone adoption by simultaneously promoting both the utilitarian and hedonic qualities of smartphones, which in turn positively influence perceived ease of use of-and attitude toward-the device respectively. Implications and directions for future research are discussed.

  15. The Feasibility and Acceptability of a Web-Based Alcohol Management Intervention in Community Sports Clubs: A Cross-Sectional Study.

    Science.gov (United States)

    McFadyen, Tameka; Wolfenden, Luke; Wiggers, John; Tindall, Jenny; Yoong, Sze Lin; Lecathelinais, Christophe; Gillham, Karen; Sherker, Shauna; Rowland, Bosco; McLaren, Nicola; Kingsland, Melanie

    2017-06-30

    The implementation of comprehensive alcohol management strategies can reduce excessive alcohol use and reduce the risk of alcohol-related harm at sporting venues. Supporting sports venues to implement alcohol management strategies via the Web may represent an effective and efficient means of reducing harm caused by alcohol in this setting. However, the feasibility and acceptability of such an approach is unknown. This study aimed to identify (1) the current access to and use of the Web and electronic devices by sports clubs; (2) the perceived usefulness, ease of use, and intention to use a Web-based program to support implementation of alcohol management policies in sports clubs; (3) the factors associated with intention to use such a Web-based support program; and (4) the specific features of such a program that sports clubs would find useful. A cross-sectional survey was conducted with club administrators of community football clubs in the state of New South Wales, Australia. Perceived usefulness, ease of use and intention to use a hypothetical Web-based alcohol management support program was assessed using the validated Technology Acceptance Model (TAM) instrument. Associations between intention to use a Web-based program and club characteristics as well as perceived ease of use and usefulness was tested using Fisher's exact test and represented using relative risk (RR) for high intention to use the program. Of the 73 football clubs that were approached to participate in the study, 63 consented to participate and 46 were eligible and completed the survey. All participants reported having access to the Web and 98% reported current use of electronic devices (eg, computers, iPads/tablets, smartphones, laptops, televisions, and smartboards). Mean scores (out of a possible 7) for the TAM constructs were high for intention to use (mean 6.25, SD 0.87), perceived ease of use (mean 6.00, SD 0.99), and perceived usefulness (mean 6.17, SD 0.85). Intention to use the Web

  16. Evaluation of management information systems: a study at a further education and training college

    CSIR Research Space (South Africa)

    Visser, M

    2013-03-01

    Full Text Available Lean IS success model (D&M IS Success Model) • the Technology Acceptance Model (TAM) • the Task-Technology Fit model (TTF) • the End User Computing Satisfaction model (EUCS). Many researchers in the field of IS evaluation have conducted empirical studies... • the Updated DeLone and McLean (D&M) IS Success model • the Model of User Satisfaction • the Re-specified Model of IS success • the End-user Computing Satisfaction model (EUCS). Three models, namely, the Original D&M IS Success model, the Updated D...

  17. Exploring gender differences on general and specific computer self-efficacy in mobile learning adoption

    OpenAIRE

    Bao, Yukun; Xiong, Tao; Hu, Zhongyi; Kibelloh, Mboni

    2014-01-01

    Reasons for contradictory findings regarding the gender moderate effect on computer self-efficacy in the adoption of e-learning/mobile learning are limited. Recognizing the multilevel nature of the computer self-efficacy (CSE), this study attempts to explore gender differences in the adoption of mobile learning, by extending the Technology Acceptance Model (TAM) with general and specific CSE. Data collected from 137 university students were tested against the research model using the structur...

  18. Antecedents and Consequences of Social Media Adoption in Travel and Tourism: Evidence from Customers and Industry

    OpenAIRE

    Mohamed A. Abou-Shouk; Mahamoud M. Hewedi

    2016-01-01

    This study extends technology acceptance model (TAM) to investigate the antecedents and consequences of social media adoption by tourists and travel agents. It compares their perceptions on social media adoption and its consequences. Online survey was addressed to tourists and travel agents for data collection purposes. Structural equation modelling was employed for analysis purposes. The findings revealed that the majority of tourists and travel agents involved in the study believe in the us...

  19. South African physicians’ acceptance of e-prescribing technology: an empirical test of a modified UTAUT model

    Directory of Open Access Journals (Sweden)

    Jason Cohen

    2013-07-01

    Full Text Available E-prescribing systems hold promise for improving the quality and efficiency of the scripting process. Yet, the use of the technology has been associated with a number of challenges. The diffusion of e-prescribing into physician practices and the consequent realisation of its potential benefits will depend on whether physicians are willing to accept and engage with the technology. This study draws on the Unified Theory of Acceptance and Use of Technology (UTAUT and recent literature on user trust in technology to develop and test a model of the factors influencing South African physicians’ acceptance of e-prescribing. Data was collected from a sample of 72 physicians. Results indicate a general acceptance of e-prescribing amongst physicians who on average reported strong intentions to use e-prescribing technologies if given the opportunity. PLS analysis revealed that physicians’ performance expectancies and perceptions of facilitating conditions had significant direct effects on acceptance whilst trust and effort expectancy had important indirect effects. Social influence and price value perceptions did not add additional explanatory power. The model explained 63% of the variation in physician acceptance.

  20. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.

    Science.gov (United States)

    Shchors, Ksenya; Persson, Anders I; Rostker, Fanya; Tihan, Tarik; Lyubynska, Natalya; Li, Nan; Swigart, Lamorna Brown; Berger, Mitchel S; Hanahan, Douglas; Weiss, William A; Evan, Gerard I

    2013-04-16

    Based on clinical presentation, glioblastoma (GBM) is stratified into primary and secondary types. The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific mechanisms. To model human gliomagenesis, we used a GFAP-HRas(V12) mouse model crossed into the p53ER(TAM) background, such that either one or both copies of endogenous p53 is replaced by a conditional p53ER(TAM) allele. The p53ER(TAM) protein can be toggled reversibly in vivo between wild-type and inactive conformations by administration or withdrawal of 4-hydroxytamoxifen (4-OHT), respectively. Surprisingly, gliomas that develop in GFAP-HRas(V12);p53(+/KI) mice abrogate the p53 pathway by mutating p19(ARF)/MDM2 while retaining wild-type p53 allele. Consequently, such tumors are unaffected by restoration of their p53ER(TAM) allele. By contrast, gliomas arising in GFAP-HRas(V12);p53(KI/KI) mice develop in the absence of functional p53. Such tumors retain a functional p19(ARF)/MDM2-signaling pathway, and restoration of p53ER(TAM) allele triggers p53-tumor-suppressor activity. Congruently, growth inhibition upon normalization of mutant p53 by a small molecule, Prima-1, in human GBM cultures also requires p14(ARF)/MDM2 functionality. Notably, the antitumoral efficacy of p53 restoration in tumor-bearing GFAP-HRas(V12);p53(KI/KI) animals depends on the duration and frequency of p53 restoration. Thus, intermittent exposure to p53ER(TAM) activity mitigated the selective pressure to inactivate the p19(ARF)/MDM2/p53 pathway as a means of resistance, extending progression-free survival. Our results suggest that intermittent dosing regimes of drugs that restore wild-type tumor-suppressor function onto mutant, inactive p53 proteins will prove to be more efficacious than traditional chronic dosing by similarly reducing adaptive resistance.

  1. Análisis de cocitación de autor en el modelo de aceptación tecnológico, 2005-2010

    Directory of Open Access Journals (Sweden)

    Córdoba-Cely, Carlos

    2012-06-01

    Full Text Available This paper explores the research trends of the Technology Acceptance Model (TAM using Author co-citation analysis (ACA methods, from January 2005 to June 2010. Through the ISI Web of Knowledge (WoK 38 key authors were selected: a Factor Analysis was performed and different techniques of information visualization, such as Multidimensional Scaling (MDS and Pathfinder Network (PFNET, were applied. The goal of this article is to identify the most popular research topics of TAM over the five years studied. The results obtained reveal two new research themes, as well as the existence of three constructs highlighted by researchers of TAM. The results are discussed.

    Este artículo explora las tendencias de investigación en el Modelo de Aceptación Tecnológico (TAM a través del método de Análisis de Cocitación de Autor (ACA entre los anos 2005 y 2010. Por medio de la ISI Web of Knowledge (WoK se identificaron 38 autores claves sobre los cuales se realizó un Análisis Factorial y un análisis de redes Pathfinder. El objetivo de este documento es complementar estas técnicas de visualización de conocimiento para identificar los tópicos de investigación más populares en los últimos cinco años del TAM. Los resultados muestran la existencia de dos nuevos tópicos de investigación así como la existencia de tres constructos destacados por los investigadores del TAM. Se discuten los resultados obtenidos.

  2. Dynamic Support of Government in Online Shopping

    OpenAIRE

    Hai, Le Chi; Alam Kazmi, Syed Hasnain

    2015-01-01

    Advancements in online shopping for consumers requires consistent government support policies and the introduction of substantial government laws and regulations. In order to establish innovative developments in online shopping market environment that makes online shopping faster and stable, the government perspective is vital with the Technology Acceptance Model (TAM) for research and development in online shopping behavior for consumer’s confidence and their purchase intention. The proposed...

  3. 456 Hours to Train the Reserve Component: Analysis of the Impact of Increased Annual Training Requirements on 4th Assault Amphibian Battalion

    Science.gov (United States)

    2016-12-01

    blended learning format” (p. 92). Online training can be used in the following ways: a sole source of learning , supplemental traditional, follow-up to... Learned MCI Marine Corps Institute MCO Marine Corps Order MCR Marine Corps Reserve MCTIMS Marine Corps Training Information Management System MCTL...Reserve SMCR Selected Marine Corps Reserve SNCO Staff Noncommissioned Officer SUL Small Unit Leader TAM Technology Acceptance Model TEEP Training

  4. ICT & OTs: a model of information and communications technology acceptance and utilisation by occupational therapists (part 2).

    Science.gov (United States)

    Schaper, Louise; Pervan, Graham

    2007-01-01

    The research reported in this paper describes the development, empirical validation and analysis of a model of technology acceptance by Australian occupational therapists. The study described involved the collection of quantitative data through a national survey. The theoretical significance of this work is that it uses a thoroughly constructed research model, with one of the largest sample sizes ever tested (n=1605), to extend technology acceptance research into the health sector. Results provide strong support for the model. This work reveals the complexity of the constructs and relationships that influence technology acceptance and highlights the need to include sociotechnical and system issues in studies of technology acceptance in healthcare to improve information system implementation success in this arena. The results of this study have practical and theoretical implications for health informaticians and researchers in the field of health informatics and information systems, tertiary educators, Commonwealth and State Governments and the allied health professions.

  5. A trap activation model for hydrogen retention and isotope exchange in some refractory materials

    International Nuclear Information System (INIS)

    Brice, D.K.; Doyle, B.L.

    1982-01-01

    Our recently-developed Local Mixing Model (LMM) has been successful in describing and predicting the properties of hydrogen retention and isotope exchange for a variety of refractory materials. For some materials, however, the detailed predictions of the LMM are not observed. A Trap Activation Model (TAM) is proposed here to account for the observed departures from the LMM. Comparison of experimental room temperature saturation depth profiles for H + →Si with the predictions of TAM suggests that the hydrogen traps are multiple-vacancy complexes in this system. The observed profiles result from a beam-induced competition between trap creation/annihilation and H-trapping/detrapping. (orig.)

  6. Acceptability and Feasibility of a Shared Decision-Making Model in Work Rehabilitation: A Mixed-Methods Study of Stakeholders' Perspectives.

    Science.gov (United States)

    Coutu, Marie-France; Légaré, France; Durand, Marie-José; Stacey, Dawn; Labrecque, Marie-Elise; Corbière, Marc; Bainbridge, Lesley

    2018-04-16

    Purpose To establish the acceptability and feasibility of implementing a shared decision-making (SDM) model in work rehabilitation. Methods We used a sequential mixed-methods design with diverse stakeholder groups (representatives of private and public employers, insurers, and unions, as well as workers having participated in a work rehabilitation program). First, a survey using a self-administered questionnaire enabled stakeholders to rate their level of agreement with the model's acceptability and feasibility and propose modifications, if necessary. Second, eight focus groups representing key stakeholders (n = 34) and four one-on-one interviews with workers were conducted, based on the questionnaire results. For each stakeholder group, we computed the percentage of agreement with the model's acceptability and feasibility and performed thematic analyses of the transcripts. Results Less than 50% of each stakeholder group initially agreed with the overall acceptability and feasibility of the model. Stakeholders proposed 37 modifications to the objectives, 17 to the activities, and 39 to improve the model's feasibility. Based on in-depth analysis of the transcripts, indicators were added to one objective, an interview guide was added as proposed by insurers to ensure compliance of the SDM process with insurance contract requirements, and one objective was reformulated. Conclusion Despite initially low agreement with the model's acceptability on the survey, subsequent discussions led to three minor changes and contributed to the model's ultimate acceptability and feasibility. Later steps will involve assessing the extent of implementation of the model in real rehabilitation settings to see if other modifications are necessary before assessing its impact.

  7. Anti-cancer Effect of Xao Tam Phan Paramignya trimera Methanol Root Extract on Human Breast Cancer Cell Line MCF-7 in 3D Model.

    Science.gov (United States)

    Nguyen-Thi, Lam-Huyen; Nguyen, Sinh Truong; Tran, Thao Phuong; Phan-Lu, Chinh-Nhan; The Van, Trung; Van Pham, Phuc

    2018-04-24

    Cancer is one of the leading causes of death in the world. A great deal of effort has been made to discover new agents for cancer treatment. Xao tam phan (Paramignya trimera) is a traditional medicine of Vietnam used in cancer treatment for a long time, yet there is not much scientific evidence proving its anticancer potency. The study aimed to evaluate the toxicity of Paramignya trimera extract (PTE) on multicellular tumor spheres (MCTS) of MCF-7 cells using hanging drop technique. Firstly, MCF-7 cells were seeded on hanging drop plates, spheroid size was tracked, and growth curve was measured by MTT assay and AlamarBlue ® assay. The necrotic core of MCTS was evaluated by propidium iodide (PI) staining. Toxicity of doxorubicin (DOX) and tirapazamine (TPZ) was then tested on 3D model compared to 2D culture condition. The results showed that the IC50 of DOX on 3D MCF-7 cells was nearly 50 times greater than monolayer MCF-7 cells. In contrast, TPZ (an agent which is specifically toxic under hypoxic conditions) had significantly lower IC50 in 3D condition than in 2D. The toxicity tests for PTE showed that PTE strongly inhibited MCF-7 cells in both 2D and 3D conditions. Interestingly, the IC50 of PTE in 3D model was remarkably lower than in 2D (IC50 value was 168.9 ± 11.65 μg/ml compared to 260.8 ± 16.54 μg/ml, respectively). The invasion assay showed that PTE completely inhibited invasion of MCF-7 cells at 250 μg/mL concentration. Also, flow cytometry results indicated that PTE effectively induced apoptosis in MCF-7 spheroids in 3D condition at 250 μg/mL concentration. The results from this study emphasize the promise of PTE in cancer therapy.

  8. The Acceptance Model of Intuitive Eating: A Comparison of Women in Emerging Adulthood, Early Adulthood, and Middle Adulthood

    Science.gov (United States)

    Augustus-Horvath, Casey L.; Tylka, Tracy L.

    2011-01-01

    The acceptance model of intuitive eating (Avalos & Tylka, 2006) posits that body acceptance by others helps women appreciate their body and resist adopting an observer's perspective of their body, which contribute to their eating intuitively/adaptively. We extended this model by integrating body mass index (BMI) into its structure and…

  9. Consumers’ Acceptance and Use of Information and Communications Technology: A UTAUT and Flow Based Theoretical Model

    Directory of Open Access Journals (Sweden)

    Saleh Alwahaishi

    2013-03-01

    Full Text Available The world has changed a lot in the past years. The rapid advances in technology and the changing of the communication channels have changed the way people work and, for many, where do they work from. The Internet and mobile technology, the two most dynamic technological forces in modern information and communications technology (ICT are converging into one ubiquitous mobile Internet service, which will change our way of both doing business and dealing with our daily routine activities. As the use of ICT expands globally, there is need for further research into cultural aspects and implications of ICT. The acceptance of Information Technology (IT has become a fundamental part of the research plan for most organizations (Igbaria 1993. In IT research, numerous theories are used to understand users’ adoption of new technologies. Various models were developed including the Technology Acceptance Model, Theory of Reasoned Action, Theory of Planned Behavior, and recently, the Unified Theory of Acceptance and Use of Technology. Each of these models has sought to identify the factors which influence a citizen’s intention or actual use of information technology. Drawing on the UTAUT model and Flow Theory, this research composes a new hybrid theoretical framework to identify the factors affecting the acceptance and use of Mobile Internet -as an ICT application- in a consumer context. The proposed model incorporates eight constructs: Performance Expectancy, Effort Expectancy, Facilitating Conditions, Social Influences, Perceived Value, Perceived Playfulness, Attention Focus, and Behavioral intention. Data collected online from 238 respondents in Saudi Arabia were tested against the research model, using the structural equation modeling approach. The proposed model was mostly supported by the empirical data. The findings of this study provide several crucial implications for ICT and, in particular, mobile Internet service practitioners and researchers

  10. A Comparison of Competing Models for Understanding Industrial Organization’s Acceptance of Cloud Services

    Directory of Open Access Journals (Sweden)

    Shui-Lien Chen

    2018-03-01

    Full Text Available Cloud computing is the next generation in computing, and the next natural step in the evolution of on-demand information technology services and products. However, only a few studies have addressed the adoption of cloud computing from an organizational perspective, which have not proven whether the research model is the best-fitting model. The purpose of this paper is to construct research competing models (RCMs and determine the best-fitting model for understanding industrial organization’s acceptance of cloud services. This research integrated the technology acceptance model and the principle of model parsimony to develop four cloud service adoption RCMs with enterprise usage intention being used as a proxy for actual behavior, and then compared the RCMs using structural equation modeling (SEM. Data derived from a questionnaire-based survey of 227 firms in Taiwan were tested against the relationships through SEM. Based on the empirical study, the results indicated that, although all four RCMs had a high goodness of fit, in both nested and non-nested structure comparisons, research competing model A (Model A demonstrated superior performance and was the best-fitting model. This study introduced a model development strategy that can most accurately explain and predict the behavioral intention of organizations to adopt cloud services.

  11. Climate change benefits and energy supply benefits as determinants of acceptance of nuclear power stations: Investigating an explanatory model

    International Nuclear Information System (INIS)

    Visschers, Vivianne H.M.; Keller, Carmen; Siegrist, Michael

    2011-01-01

    Several countries are currently discussing whether they will rebuild their nuclear power stations in order to continue this type of energy production in the future. The public, with its own opinion about nuclear power stations, has an influential voice in this discussion. As a result, policy makers and nuclear scientists are interested in the public's perception of nuclear power and in what determines this perception. We therefore examined an explanatory model of the public's acceptance of nuclear power based on a telephone survey among a representative sample in Switzerland. The model included such factors as risk perception, benefit perception, affective feelings, and social trust. Moreover, we distinguished between two types of benefit perception: benefit for the climate and a secure energy supply. The model fitted very well to our data and explained acceptance very well. Acceptance was mainly influenced by perceived benefits for a secure energy supply and, to a lesser extent, both by perceived benefits for the climate and by risk perception. Affective feelings about nuclear power appeared to be a central factor in the model. Implications for communication about nuclear power stations and for further research are discussed. - Highlights: → Explanatory model of determinants of nuclear power acceptance was studied in the representative survey. → Perceived benefits for a secure energy supply had the largest influence on acceptance. → Perceived benefits for the climate seemed less influential on acceptance. → Affect had a central role in the explanatory model. → Implications for communication about nuclear power plants are discussed.

  12. Climate change benefits and energy supply benefits as determinants of acceptance of nuclear power stations: Investigating an explanatory model

    Energy Technology Data Exchange (ETDEWEB)

    Visschers, Vivianne H.M., E-mail: vvisschers@ethz.ch [ETH Zurich, Institute for Environmental Decisions (IED), Consumer Behavior, Universitaetsstrasse 22 CHN J 75.2, 8092 Zurich (Switzerland); Keller, Carmen; Siegrist, Michael [ETH Zurich, Institute for Environmental Decisions (IED), Consumer Behavior, Universitaetsstrasse 22 CHN J 75.2, 8092 Zurich (Switzerland)

    2011-06-15

    Several countries are currently discussing whether they will rebuild their nuclear power stations in order to continue this type of energy production in the future. The public, with its own opinion about nuclear power stations, has an influential voice in this discussion. As a result, policy makers and nuclear scientists are interested in the public's perception of nuclear power and in what determines this perception. We therefore examined an explanatory model of the public's acceptance of nuclear power based on a telephone survey among a representative sample in Switzerland. The model included such factors as risk perception, benefit perception, affective feelings, and social trust. Moreover, we distinguished between two types of benefit perception: benefit for the climate and a secure energy supply. The model fitted very well to our data and explained acceptance very well. Acceptance was mainly influenced by perceived benefits for a secure energy supply and, to a lesser extent, both by perceived benefits for the climate and by risk perception. Affective feelings about nuclear power appeared to be a central factor in the model. Implications for communication about nuclear power stations and for further research are discussed. - Highlights: > Explanatory model of determinants of nuclear power acceptance was studied in the representative survey. > Perceived benefits for a secure energy supply had the largest influence on acceptance. > Perceived benefits for the climate seemed less influential on acceptance. > Affect had a central role in the explanatory model. > Implications for communication about nuclear power plants are discussed.

  13. The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: a novel insight into chronic wound immunity.

    Science.gov (United States)

    Filkor, Kata; Németh, Tibor; Nagy, István; Kondorosi, Éva; Urbán, Edit; Kemény, Lajos; Szolnoky, Győző

    2016-08-01

    The systemic host defence mechanisms, especially innate immunity, in venous leg ulcer patients are poorly investigated. The aim of the current study was to measure Candida albicans killing activity and gene expressions of pro- and anti-inflammatory cytokines and innate immune response regulators, TAM receptors and ligands of peripheral blood mononuclear cells separated from 69 venous leg ulcer patients and 42 control probands. Leg ulcer patients were stratified into responder and non-responder groups on the basis of wound healing properties. No statistical differences were found in Candida killing among controls, responders and non-responders. Circulating blood mononuclear cells of patients overexpress pro-inflammatory (IL-1α, TNFα, CXCL-8) and anti-inflammatory (IL-10) cytokines as well as TAM receptors (Tyro, Axl, MerTK) and their ligands Gas6 and Protein S compared with those of control individuals. IL-1α is notably overexpressed in venous leg ulcer treatment non-responders; in contrast, Axl gene expression is robustly stronger among responders. These markers may be considered as candidates for the prediction of treatment response among venous leg ulcer patients. © 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  14. Modeling canopy-level productivity: is the "big-leaf" simplification acceptable?

    Science.gov (United States)

    Sprintsin, M.; Chen, J. M.

    2009-05-01

    The "big-leaf" approach to calculating the carbon balance of plant canopies assumes that canopy carbon fluxes have the same relative responses to the environment as any single unshaded leaf in the upper canopy. Widely used light use efficiency models are essentially simplified versions of the big-leaf model. Despite its wide acceptance, subsequent developments in the modeling of leaf photosynthesis and measurements of canopy physiology have brought into question the assumptions behind this approach showing that big leaf approximation is inadequate for simulating canopy photosynthesis because of the additional leaf internal control on carbon assimilation and because of the non-linear response of photosynthesis on leaf nitrogen and absorbed light, and changes in leaf microenvironment with canopy depth. To avoid this problem a sunlit/shaded leaf separation approach, within which the vegetation is treated as two big leaves under different illumination conditions, is gradually replacing the "big-leaf" strategy, for applications at local and regional scales. Such separation is now widely accepted as a more accurate and physiologically based approach for modeling canopy photosynthesis. Here we compare both strategies for Gross Primary Production (GPP) modeling using the Boreal Ecosystem Productivity Simulator (BEPS) at local (tower footprint) scale for different land cover types spread over North America: two broadleaf forests (Harvard, Massachusetts and Missouri Ozark, Missouri); two coniferous forests (Howland, Maine and Old Black Spruce, Saskatchewan); Lost Creek shrubland site (Wisconsin) and Mer Bleue petland (Ontario). BEPS calculates carbon fixation by scaling Farquhar's leaf biochemical model up to canopy level with stomatal conductance estimated by a modified version of the Ball-Woodrow-Berry model. The "big-leaf" approach was parameterized using derived leaf level parameters scaled up to canopy level by means of Leaf Area Index. The influence of sunlit

  15. INTENSI MAHASISWA YOGYAKARTA BERWIRAUSAHA BERBASIS TEKNOLOGI INFORMASI (TI)

    OpenAIRE

    Tjahjono, Heru Kurnianto; Maryati, Tri; Fauziyah, Fauziyah

    2015-01-01

    AbstractThe purpose of this study is to investigate intention to be entrepreneur among university students in Yogyakarta. Based on modification of TPB (theory of planned behavior) and TAM (technology acceptance model), this research specifically examined whether entrepreneur’s personality is an important antecedent to explain attitude, risk perception and subjective norm of entrepreneur based on information technology (IT). This research tested whether attitude, risk perception and subjective...

  16. Implementing EHR in a developing country: potential challenges and benefits

    OpenAIRE

    Tanko, Abdulai

    2009-01-01

    Developing countries are slow adopters of new technologies, particularly with regards to the health services of these countries. This study explores the data collection and management challenges in a Ghanaian hospital using an interpretative case study approach and proposes implementing an Electronic Health Record (EHR) system as a solution to these challenges. The Technology Acceptance Model (TAM), Actor Network Theory (ANT) and Computer Supported Cooperative Work (CSCW) are used in discussi...

  17. Invariance of an Extended Technology Acceptance Model Across Gender and Age Group

    Science.gov (United States)

    Ahmad, Tunku Badariah Tunku; Madarsha, Kamal Basha; Zainuddin, Ahmad Marzuki; Ismail, Nik Ahmad Hisham; Khairani, Ahmad Zamri; Nordin, Mohamad Sahari

    2011-01-01

    In this study, we examined the likelihood of a TAME (extended technology acceptance model), in which the interrelationships among computer self-efficacy, perceived usefulness, intention to use and self-reported use of computer-mediated technology were tested. In addition, the gender- and age-invariant of its causal structure were evaluated. The…

  18. A model based estimate of the geometrical acceptance of the e+e- experiment on the HYPERON spectrometer

    International Nuclear Information System (INIS)

    Cerny, V.

    1983-01-01

    A model based estimate is presented of the geometrical acceptance of the HYPERON spectrometer for the detection of the e + e - pairs in the proposed lepton experiment. The results of the Monte Carlo calculation show that the expected acceptance is fairly high. (author)

  19. Numerical modelling study on the flexural uplift of the Transantarctic Mountains

    NARCIS (Netherlands)

    Yamasaki, T.; Miura, H.; Nogi, Y.

    2008-01-01

    In this study, based on a 2-D thermomechanical finite element model, the uplift of the Transantarctic Mountains (TAM) is discussed in relation to the flexural uplift of a rheologically layered lithosphere, which is described by Vening-Meinesz's cantilever kinematics. The general model behaviour

  20. Understanding social acceptance of electricity generation sources

    International Nuclear Information System (INIS)

    Bronfman, Nicolás C.; Jiménez, Raquel B.; Arévalo, Pilar C.; Cifuentes, Luis A.

    2012-01-01

    Social acceptability is a determinant factor in the failure or success of the government's decisions about which electricity generation sources will satisfy the growing demand for energy. The main goal of this study was to validate a causal trust-acceptability model for electricity generation sources. In the model, social acceptance of an energy source is directly caused by perceived risk and benefit and also by social trust in regulatory agencies (both directly and indirectly, through perceived risk and benefit). Results from a web-based survey of Chilean university students demonstrated that data for energy sources that are controversial in Chilean society (fossil fuels, hydro, and nuclear power) fit the hypothesized model, whereas data for non conventional renewable energy sources (solar, wind, geothermal and tidal) did not. Perceived benefit had the greatest total effect on acceptability, thus emerging as a key predictive factor of social acceptability of controversial electricity generation sources. Further implications for regulatory agencies are discussed. - Highlights: ► We tested a causal trust-acceptability model for electricity generation sources in Chile. ► Data for controversial energy sources in the Chilean society (fossil fuels, hydro and nuclear power) fit the hypothesized model. ► Data for non conventional renewable energy sources did not fit the data. ► Perceived benefit showed the greatest total effect on acceptability.

  1. Perspective of trust towards e-government initiatives in Sri Lanka.

    Science.gov (United States)

    Ranaweera, H M B P

    2016-01-01

    In this article, the author focuses on understanding the antecedent conditions of trustworthiness of the users towards the use of e-government services and attempt to propose a model to assess the influences of the trustworthiness for the use of e-government services in Sri Lanka. Trustworthiness was considered as an additional construct along with the technology acceptance model (TAM) constructs. Structural equation modeling (SEM) approach was used to test the proposed model by utilizing the responses of 898 citizens. SEM results reveal that the proposed model is acceptable showing goodness of fit. The proposed model tested by SEM is appropriate to assess what extend trustworthiness of the users influence for the use of e-government services and this would be worth to pay more attention on trust when develop and implement e-government initiatives.

  2. Predicting Public Bicycle Adoption Using the Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Benjamin T. Hazen

    2015-10-01

    Full Text Available Bicycle sharing programs provide a sustainable mode of urban transportation. Although cities across the globe have developed these systems for their citizens and visitors, usage rates are not as high as anticipated. This research uses the technology acceptance model as the basis to understand one’s intention to adopt bicycle sharing programs. Using survey data derived from 421 participants in Beijing, China, the proposed covariance-based structural equation model consisting of perceived quality, perceived convenience, and perceived value is found to predict 50.5% of the variance in adoption intention. The findings of this research contribute to theory and practice in the burgeoning literature on public bicycle systems and sustainable urban transportation by offering a theoretical lens through which to consider system adoption, and providing information to practitioners as to what factors might contribute most to adoption.

  3. Social trust, risk perceptions and public acceptance of recycled water: testing a social-psychological model.

    Science.gov (United States)

    Ross, Victoria L; Fielding, Kelly S; Louis, Winnifred R

    2014-05-01

    Faced with a severe drought, the residents of the regional city of Toowoomba, in South East Queensland, Australia were asked to consider a potable wastewater reuse scheme to supplement drinking water supplies. As public risk perceptions and trust have been shown to be key factors in acceptance of potable reuse projects, this research developed and tested a social-psychological model of trust, risk perceptions and acceptance. Participants (N = 380) were surveyed a few weeks before a referendum was held in which residents voted against the controversial scheme. Analysis using structural equation modelling showed that the more community members perceived that the water authority used fair procedures (e.g., consulting with the community and providing accurate information), the greater their sense of shared identity with the water authority. Shared social identity in turn influenced trust via increased source credibility, that is, perceptions that the water authority is competent and has the community's interest at heart. The findings also support past research showing that higher levels of trust in the water authority were associated with lower perceptions of risk, which in turn were associated with higher levels of acceptance, and vice versa. The findings have a practical application for improving public acceptance of potable recycled water schemes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Parental modelling and prompting effects on acceptance of a novel fruit in 2-4-year-old children are dependent on children's food responsiveness.

    Science.gov (United States)

    Blissett, Jackie; Bennett, Carmel; Fogel, Anna; Harris, Gillian; Higgs, Suzanne

    2016-02-14

    Few children consume the recommended portions of fruit or vegetables. This study examined the effects of parental physical prompting and parental modelling in children's acceptance of a novel fruit (NF) and examined the role of children's food-approach and food-avoidance traits on NF engagement and consumption. A total of 120 caregiver-child dyads (fifty-four girls, sixty-six boys) participated in this study. Dyads were allocated to one of the following three conditions: physical prompting but no modelling, physical prompting and modelling or a modelling only control condition. Dyads ate a standardised meal containing a portion of a fruit new to the child. Parents completed measures of children's food approach and avoidance. Willingness to try the NF was observed, and the amount of the NF consumed was measured. Physical prompting but no modelling resulted in greater physical refusal of the NF. There were main effects of enjoyment of food and food fussiness on acceptance. Food responsiveness interacted with condition such that children who were more food responsive had greater NF acceptance in the prompting and modelling conditions in comparison with the modelling only condition. In contrast, children with low food responsiveness had greater acceptance in the modelling control condition than in the prompting but no modelling condition. Physical prompting in the absence of modelling is likely to be detrimental to NF acceptance. Parental use of physical prompting strategies, in combination with modelling of NF intake, may facilitate acceptance of NF, but only in food-responsive children. Modelling consumption best promotes acceptance in children with low food responsiveness.

  5. Model of acceptance of a new type of beverage: application to natural sparkling red wine

    Directory of Open Access Journals (Sweden)

    Cristina Olarte

    2017-04-01

    Full Text Available Wine is a traditional beverage with a saturated market, in which consumers are open to innovation. In this context, an innovative experience was launched to create a new natural sparkling red wine with a view to diversifying production and studying its acceptance. This paper uses an original acceptance model for new foods called the Cognitive-Affective-Normative (CAN model. The model was tested on a sample of 500 Spanish consumers in a real-world test context and explains 64.1% of the intention to consume the new wine.  The results showed the importance of the cognitive factor in consumer intention. In particular, sensory and price benefits were found to be the key criteria explaining the intention to consume (41.34%. The results also confirmed the usefulness of expanding the factors that determine new food acceptance to include the emotional and normative dimensions of consumer behaviour. The social norm (18.54% and affective factors (4.2% contributed to the explanation of the underlying reasons influencing consumers’ assessments of the product. It is proposed that efforts focus on new visual, olfactory and taste-related sensations with a view to producing an appetising product that offers good value for money. Research and development institutes should innovate towards products that highlight these sensations. Therefore, attention should be drawn to the importance of acting on potential consumers’ reference groups and membership groups, with a view to involving them in recommending the product. Managers should focus on measuring and influencing social opinion, working on marketing communication to achieve acceptance.

  6. Model of acceptance of a new type of beverage: application to natural sparkling red wine

    International Nuclear Information System (INIS)

    Olarte, C.; Pelegrín, J.; Reinares, E.

    2017-01-01

    Wine is a traditional beverage with a saturated market, in which consumers are open to innovation. In this context, an innovative experience was launched to create a new natural sparkling red wine with a view to diversifying production and studying its acceptance. This paper uses an original acceptance model for new foods called the Cognitive-Affective-Normative (CAN) model. The model was tested on a sample of 500 Spanish consumers in a real-world test context and explains 64.1% of the intention to consume the new wine. The results showed the importance of the cognitive factor in consumer intention. In particular, sensory and price benefits were found to be the key criteria explaining the intention to consume (41.34%). The results also confirmed the usefulness of expanding the factors that determine new food acceptance to include the emotional and normative dimensions of consumer behaviour. The social norm (18.54%) and affective factors (4.2%) contributed to the explanation of the underlying reasons influencing consumers’ assessments of the product. It is proposed that efforts focus on new visual, olfactory and taste-related sensations with a view to producing an appetising product that offers good value for money. Research and development institutes should innovate towards products that highlight these sensations. Therefore, attention should be drawn to the importance of acting on potential consumers’ reference groups and membership groups, with a view to involving them in recommending the product. Managers should focus on measuring and influencing social opinion, working on marketing communication to achieve acceptance.

  7. Model of acceptance of a new type of beverage: application to natural sparkling red wine

    Energy Technology Data Exchange (ETDEWEB)

    Olarte, C.; Pelegrín, J.; Reinares, E.

    2017-09-01

    Wine is a traditional beverage with a saturated market, in which consumers are open to innovation. In this context, an innovative experience was launched to create a new natural sparkling red wine with a view to diversifying production and studying its acceptance. This paper uses an original acceptance model for new foods called the Cognitive-Affective-Normative (CAN) model. The model was tested on a sample of 500 Spanish consumers in a real-world test context and explains 64.1% of the intention to consume the new wine. The results showed the importance of the cognitive factor in consumer intention. In particular, sensory and price benefits were found to be the key criteria explaining the intention to consume (41.34%). The results also confirmed the usefulness of expanding the factors that determine new food acceptance to include the emotional and normative dimensions of consumer behaviour. The social norm (18.54%) and affective factors (4.2%) contributed to the explanation of the underlying reasons influencing consumers’ assessments of the product. It is proposed that efforts focus on new visual, olfactory and taste-related sensations with a view to producing an appetising product that offers good value for money. Research and development institutes should innovate towards products that highlight these sensations. Therefore, attention should be drawn to the importance of acting on potential consumers’ reference groups and membership groups, with a view to involving them in recommending the product. Managers should focus on measuring and influencing social opinion, working on marketing communication to achieve acceptance.

  8. Adoption of Social Networking Sites among Pakistani University Students: A Case of Face-Book

    OpenAIRE

    Raja Irfan Sabir; Wasim Ahmad; Nabila Noor; Asad-ur-Rehman

    2013-01-01

    Since birth of Social Networking Sites (SNSs), these attracted millions of users from all around the world. The SNSs have changed the communication ways of people from more traditional to modern approaches. This study aims to examine diffusion and adoption of Facebook.com among Pakistani university students using Technology Acceptance Model (TAM) and Theory of Reasoned Action (TRA) with an extension of Theory of Planned Behavior (TPB). The study used stratified random & pre-tested questionnai...

  9. Mobile Tourism Guide in the Context of Thai National Parks: The Effects of Mobile Design Qualities in TAM2

    Directory of Open Access Journals (Sweden)

    Trakulmaykee Numtip

    2014-01-01

    Full Text Available This study aims to predict the level of international tourists’ intention to use MTG in the context of Thai national parks, and investigates the roles of mobile design qualities (content quality, appearance quality, and interaction quality through perceived usefulness and perceived ease-of-use on intention. The mixed-method via exploratory sequential design is conducted this study. The qualitative approach is started in the first stage then quantitative approach is employed to analyze the large sample size. This study extends the TAM2 with mobile design qualities. The results shows the high level of international tourist’ intention to use MTG. It indicates that the international tourists will intent to the mobile tourism guide (MTG, if the MTG is provided for them. The direct factors of tourists’ intention are perceived usefulness, perceived ease-of-use, mobile content quality and mobile appearance quality. The most direct effect is mobile content quality. The qualities of content and appearance have the positive roles on perceived usefulness, while the qualities of appearance and interaction have the indirect effects through perceived ease-of-use on tourists’ intention. The proposed model provides the body of knowledge in the context of MTG, especially the factors of international tourists’ intention to use MTG.

  10. Acceptance and Usability of OER in India: An Investigation Using UTAUT Model

    Directory of Open Access Journals (Sweden)

    Nayantara Padhi

    2018-02-01

    Full Text Available In the global movement towards open knowledge society, open educational resources (OER have become a prominent contributor as a medium of education, research and training. In India, the phenomenon of OER is still in nascent stage. Although the country has been massively investing on growth and usage of ICT, it still requires acceptance of OER as a medium of education, research or training. Particularly, adoption and usage of OER posses several challenges such as accessibility, reliability, copy right etc. There is plethora of research studies on the ICT usage in education in India, but there is hardly any empirical research evidence on OER in India. With this backdrop, at the first instance it is very much essential to investigate the acceptance and usability of OER in India. This paper focuses on faculty perception by applying Unified Theory of Acceptance and Use of Technology (UTAUT model. Apart from this, the study also identifies the challenges associated with OER. For the purpose of this survey data is collected from 22 Indian universities located pan India. The outcome of this empirical research shall certainly useful and provide guidelines for the policy makers and users of OER in India.

  11. A revised oceanographic model to calculate the limiting capacity of the ocean to accept radioactive waste

    International Nuclear Information System (INIS)

    Webb, G.A.M.; Grimwood, P.D.

    1976-12-01

    This report describes an oceanographic model which has been developed for the use in calculating the capacity of the oceans to accept radioactive wastes. One component is a relatively short-term diffusion model which is based on that described in an earlier report (Webb et al., NRPB-R14(1973)), but which has been generalised to some extent. Another component is a compartment model which is used to calculate long-term widespread water concentrations. This addition overcomes some of the short comings of the earlier diffusion model. Incorporation of radioactivity into deep ocean sediments is included in this long-term model as a removal mechanism. The combined model is used to provide a conservative (safe) estimate of the maximum concentrations of radioactivity in water as a function of time after the start of a continuous disposal operation. These results can then be used to assess the limiting capacity of an ocean to accept radioactive waste. (author)

  12. Offer acceptance practices and geographic variability in allocation model for end-stage liver disease at transplant.

    Science.gov (United States)

    Wey, Andrew; Pyke, Joshua; Schladt, David P; Gentry, Sommer E; Weaver, Tim; Salkowski, Nicholas; Kasiske, Bertram L; Israni, Ajay K; Snyder, Jon J

    2018-04-01

    Offer acceptance practices may cause geographic variability in allocation Model for End-Stage Liver Disease (aMELD) score at transplant and could magnify the effect of donor supply and demand on aMELD variability. To evaluate these issues, offer acceptance practices of liver transplant programs and donation service areas (DSAs) were estimated using offers of livers from donors recovered between January 1, 2016, and December 31, 2016. Offer acceptance practices were compared with liver yield, local placement of transplanted livers, donor supply and demand, and aMELD at transplant. Offer acceptance was associated with liver yield (odds ratio, 1.32; P offer acceptance (r = 0.09; P = 0.50). Additionally, the association between DSA-level donor-to-candidate ratios and aMELD at transplant did not change after adjustment for offer acceptance. The average squared difference in median aMELD at transplant across DSAs was 24.6; removing the effect of donor-to-candidate ratios reduced the average squared differences more than removing the effect of program-level offer acceptance (33% and 15% reduction, respectively). Offer acceptance practices and donor-to-candidate ratios independently contributed to geographic variability in aMELD at transplant. Thus, neither offer acceptance nor donor-to-candidate ratios can explain all of the geographic variability in aMELD at transplant. Liver Transplantation 24 478-487 2018 AASLD. © 2018 by the American Association for the Study of Liver Diseases.

  13. Acceptability of GM foods among Pakistani consumers

    Science.gov (United States)

    Ali, Akhter; Rahut, Dil Bahadur; Imtiaz, Muhammad

    2016-01-01

    ABSTRACT In Pakistan majority of the consumers do not have information about genetically modified (GM) foods. In developing countries particularly in Pakistan few studies have focused on consumers' acceptability about GM foods. Using comprehensive primary dataset collected from 320 consumers in 2013 from Pakistan, this study analyzes the determinants of consumers' acceptability of GM foods. The data was analyzed by employing the bivariate probit model and censored least absolute deviation (CLAD) models. The empirical results indicated that urban consumers are more aware of GM foods compared to rural consumers. The acceptance of GM foods was more among females' consumers as compared to male consumers. In addition, the older consumers were more willing to accept GM food compared to young consumers. The acceptability of GM foods was also higher among wealthier households. Low price is the key factor leading to the acceptability of GM foods. The acceptability of the GM foods also reduces the risks among Pakistani consumers. PMID:27494790

  14. Acceptability of GM foods among Pakistani consumers.

    Science.gov (United States)

    Ali, Akhter; Rahut, Dil Bahadur; Imtiaz, Muhammad

    2016-04-02

    In Pakistan majority of the consumers do not have information about genetically modified (GM) foods. In developing countries particularly in Pakistan few studies have focused on consumers' acceptability about GM foods. Using comprehensive primary dataset collected from 320 consumers in 2013 from Pakistan, this study analyzes the determinants of consumers' acceptability of GM foods. The data was analyzed by employing the bivariate probit model and censored least absolute deviation (CLAD) models. The empirical results indicated that urban consumers are more aware of GM foods compared to rural consumers. The acceptance of GM foods was more among females' consumers as compared to male consumers. In addition, the older consumers were more willing to accept GM food compared to young consumers. The acceptability of GM foods was also higher among wealthier households. Low price is the key factor leading to the acceptability of GM foods. The acceptability of the GM foods also reduces the risks among Pakistani consumers.

  15. Hierarchical Self Assembly of Patterns from the Robinson Tilings: DNA Tile Design in an Enhanced Tile Assembly Model.

    Science.gov (United States)

    Padilla, Jennifer E; Liu, Wenyan; Seeman, Nadrian C

    2012-06-01

    We introduce a hierarchical self assembly algorithm that produces the quasiperiodic patterns found in the Robinson tilings and suggest a practical implementation of this algorithm using DNA origami tiles. We modify the abstract Tile Assembly Model, (aTAM), to include active signaling and glue activation in response to signals to coordinate the hierarchical assembly of Robinson patterns of arbitrary size from a small set of tiles according to the tile substitution algorithm that generates them. Enabling coordinated hierarchical assembly in the aTAM makes possible the efficient encoding of the recursive process of tile substitution.

  16. Stress exposure and generation: A conjoint longitudinal model of body dysmorphic symptoms, peer acceptance, popularity, and victimization.

    Science.gov (United States)

    Webb, Haley J; Zimmer-Gembeck, Melanie J; Mastro, Shawna

    2016-09-01

    This study examined the bidirectional (conjoint) longitudinal pathways linking adolescents' body dysmorphic disorder (BDD) symptoms with self- and peer-reported social functioning. Participants were 367 Australian students (45.5% boys, mean age=12.01 years) who participated in two waves of a longitudinal study with a 12-month lag between assessments. Participants self-reported their symptoms characteristic of BDD, and perception of peer acceptance. Classmates reported who was popular and victimized in their grade, and rated their liking (acceptance) of their classmates. In support of both stress exposure and stress generation models, T1 victimization was significantly associated with more symptoms characteristic of BDD at T2 relative to T1, and higher symptom level at T1 was associated with lower perceptions of peer acceptance at T2 relative to T1. These results support the hypothesized bidirectional model, whereby adverse social experiences negatively impact symptoms characteristic of BDD over time, and symptoms also exacerbate low perceptions of peer-acceptance. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Modeling nurses' attitude toward using automated unit-based medication storage and distribution systems: an extension of the technology acceptance model.

    Science.gov (United States)

    Escobar-Rodríguez, Tomás; Romero-Alonso, María Mercedes

    2013-05-01

    This article analyzes the attitude of nurses toward the use of automated unit-based medication storage and distribution systems and identifies influencing factors. Understanding these factors provides an opportunity to explore actions that might be taken to boost adoption by potential users. The theoretical grounding for this research is the Technology Acceptance Model. The Technology Acceptance Model specifies the causal relationships between perceived usefulness, perceived ease of use, attitude toward using, and actual usage behavior. The research model has six constructs, and nine hypotheses were generated from connections between these six constructs. These constructs include perceived risks, experience level, and training. The findings indicate that these three external variables are related to the perceived ease of use and perceived usefulness of automated unit-based medication storage and distribution systems, and therefore, they have a significant influence on attitude toward the use of these systems.

  18. Evaluation model for safety capacity of chemical industrial park based on acceptable regional risk

    Institute of Scientific and Technical Information of China (English)

    Guohua Chen; Shukun Wang; Xiaoqun Tan

    2015-01-01

    The paper defines the Safety Capacity of Chemical Industrial Park (SCCIP) from the perspective of acceptable regional risk. For the purpose of exploring the evaluation model for the SCCIP, a method based on quantitative risk assessment was adopted for evaluating transport risk and to confirm reasonable safety transport capacity of chemical industrial park, and then by combining with the safety storage capacity, a SCCIP evaluation model was put forward. The SCCIP was decided by the smaller one between the largest safety storage capacity and the maximum safety transport capacity, or else, the regional risk of the park will exceed the acceptable level. The developed method was applied to a chemical industrial park in Guangdong province to obtain the maximum safety transport capacity and the SCCIP. The results can be realized in the regional risk control of the park effectively.

  19. A fuzzy inventory model with acceptable shortage using graded mean integration value method

    Science.gov (United States)

    Saranya, R.; Varadarajan, R.

    2018-04-01

    In many inventory models uncertainty is due to fuzziness and fuzziness is the closed possible approach to reality. In this paper, we proposed a fuzzy inventory model with acceptable shortage which is completely backlogged. We fuzzily the carrying cost, backorder cost and ordering cost using Triangular and Trapezoidal fuzzy numbers to obtain the fuzzy total cost. The purpose of our study is to defuzzify the total profit function by Graded Mean Integration Value Method. Further a numerical example is also given to demonstrate the developed crisp and fuzzy models.

  20. Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts.

    Directory of Open Access Journals (Sweden)

    Laetitia Fend

    Full Text Available Tumor progression is promoted by Tumor-Associated Macrophages (TAMs and metastasis-induced bone destruction by osteoclasts. Both myeloid cell types depend on the CD115-CSF-1 pathway for their differentiation and function. We used 3 different mouse cancer models to study the effects of targeting cancer host myeloid cells with a monoclonal antibody (mAb capable of blocking CSF-1 binding to murine CD115. In mice bearing sub-cutaneous EL4 tumors, which are CD115-negative, the anti-CD115 mAb depleted F4/80(+ CD163(+ M2-type TAMs and reduced tumor growth, resulting in prolonged survival. In the MMTV-PyMT mouse model, the spontaneous appearance of palpable mammary tumors was delayed when the anti-CD115 mAb was administered before malignant transition and tumors became palpable only after termination of the immunotherapy. When administered to mice already bearing established PyMT tumors, anti-CD115 treatment prolonged their survival and potentiated the effect of chemotherapy with Paclitaxel. As shown by immunohistochemistry, this therapeutic effect correlated with the depletion of F4/80(+CD163(+ M2-polarized TAMs. In a breast cancer model of bone metastasis, the anti-CD115 mAb potently blocked the differentiation of osteoclasts and their bone destruction activity. This resulted in the inhibition of cancer-induced weight loss. CD115 thus represents a promising target for cancer immunotherapy, since a specific blocking antibody may not only inhibit the growth of a primary tumor through TAM depletion, but also metastasis-induced bone destruction through osteoclast inhibition.

  1. Establishment of a Model of Microencapsulated SGC7901 Human Gastric Carcinoma Cells Cocultured with Tumor-Associated Macrophages

    Directory of Open Access Journals (Sweden)

    Jin-Ming Zhu

    2018-01-01

    Full Text Available The important factors of poor survival of gastric cancer (GC are relapse and metastasis. For further elucidation of the mechanism, a culture system mimicking the microenvironment of the tumor in humans was needed. We established a model of microencapsulated SGC7901 human GC cells and evaluated the effects of coculturing spheres with tumor-associated macrophages (TAMs. SGC7901 cells were encapsulated in alginate-polylysine-sodium alginate (APA microcapsules using an electrostatic droplet generator. MTT assays showed that the numbers of microencapsulated cells were the highest after culturing for 14 days. Metabolic curves showed consumption of glucose and production of lactic acid by day 20. Immunocytochemistry confirmed that Proliferating Cell Nuclear Antigen (PCNA and Vascular Endothelial Growth Factor (VEGF were expressed in microencapsulated SGC7901 cells on days 7 and 14. The expression of PCNA was observed outside spheroids; however, VEGF was found in the entire spheroids. PCNA and VEGF were increased after being cocultured with TAMs. Matrix metalloproteinase-2 (MMP-2 and matrix metalloproteinase-9 (MMP-9 expressions were detected in the supernatant of microencapsulated cells cocultured with TAMs but not in microencapsulated cells. Our study confirms the successful establishment of the microencapsulated GC cells. TAMs can promote PCNA, VEGF, MMP-2, and MMP-9 expressions of the GC cells.

  2. Motivation and innovation: Mobile technology acceptance among student teachers

    Directory of Open Access Journals (Sweden)

    José Carlos Sánchez-Prieto

    2017-05-01

    Full Text Available Mobile technologies constitute a didactic resource with great potential. However, their incorporation process to the classroom is not being implemented in a satisfying way. The future teachers will play a key role in the integration process of these technologies’ integration process in formal education contexts and, therefore, it is essential to know the factors that condition their decision-making process.This article presents the results of a research which analyzes the influence of motivational factors on the behavioral intention to use mobile technologies in the future teaching practice of the students from the Pre-primary Education Degree from the University of Salamanca. With this purpose, we have developed a TAM-based technology adoption model including the following constructs: perceived usefulness, perceived ease of use, perceived enjoyment, resistance to change and behavioral intention. The employed PLS-SEM analysis confirms the validity and reliability of the model. The results of the analysis of the structural model reflect the importance of perceived enjoyment and perceived usefulness in the adoption process, as well as the low relevance of perceived ease of use. In total, the motivational factors enable the prediction of a high percentage of the variance of behavioral intention, which reveals the need to design educational programmes that emphasize on these elements.

  3. The challenges of modelling phosphorus in a headwater catchment: Applying a 'limits of acceptability' uncertainty framework to a water quality model

    Science.gov (United States)

    Hollaway, M. J.; Beven, K. J.; Benskin, C. McW. H.; Collins, A. L.; Evans, R.; Falloon, P. D.; Forber, K. J.; Hiscock, K. M.; Kahana, R.; Macleod, C. J. A.; Ockenden, M. C.; Villamizar, M. L.; Wearing, C.; Withers, P. J. A.; Zhou, J. G.; Barber, N. J.; Haygarth, P. M.

    2018-03-01

    There is a need to model and predict the transfer of phosphorus (P) from land to water, but this is challenging because of the large number of complex physical and biogeochemical processes involved. This study presents, for the first time, a 'limits of acceptability' approach of the Generalized Likelihood Uncertainty Estimation (GLUE) framework to the Soil and Water Assessment Tool (SWAT), in an application to a water quality problem in the Newby Beck catchment (12.5 km2), Cumbria, United Kingdom (UK). Using high frequency outlet data (discharge and P), individual evaluation criteria (limits of acceptability) were assigned to observed discharge and P loads for all evaluation time steps, identifying where the model was performing well/poorly and to infer which processes required improvement in the model structure. Initial limits of acceptability were required to be relaxed by a substantial amount (by factors of between 5.3 and 6.7 on a normalized scale depending on the evaluation criteria used) in order to gain a set of behavioral simulations (1001 and 1016, respectively out of 5,000,000). Of the 39 model parameters tested, the representation of subsurface processes and associated parameters, were consistently shown as critical to the model not meeting the evaluation criteria, irrespective of the chosen evaluation metric. It is therefore concluded that SWAT is not an appropriate model to guide P management in this catchment. This approach highlights the importance of high frequency monitoring data for setting robust model evaluation criteria. It also raises the question as to whether it is possible to have sufficient input data available to drive such models so that we can have confidence in their predictions and their ability to inform catchment management strategies to tackle the problem of diffuse pollution from agriculture.

  4. Do we have an acceptable model of power-law creep?

    CSIR Research Space (South Africa)

    Nabarro, FRN

    2004-12-15

    Full Text Available 387–389 (2004) 659–664 Do we have an acceptable model of power-law creep? F.R.N. Nabarro a,b,∗ a Condensed Matter Physics Research Group, School of Physics, University of the Witwatersrand, Private Bag 3, Johannesburg WITS 2050, South Africa b... an exponential function 0921-5093/$ – see front matter © 2004 Published by Elsevier B.V. doi:10.1016/j.msea.2003.09.118 660 F.R.N. Nabarro / Materials Science and Engineering A 387–389 (2004) 659–664 of the stress. There is little evidence whether the physical...

  5. Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: expert opinions on the state of affairs and the way forward.

    Science.gov (United States)

    Schiffelers, Marie-Jeanne W A; Blaauboer, Bas J; Bakker, Wieger E; Beken, Sonja; Hendriksen, Coenraad F M; Koëter, Herman B W M; Krul, Cyrille

    2014-06-01

    Pharmaceuticals and chemicals are subjected to regulatory safety testing accounting for approximately 25% of laboratory animal use in Europe. This testing meets various objections and has led to the development of a range of 3R models to Replace, Reduce or Refine the animal models. However, these models must overcome many barriers before being accepted for regulatory risk management purposes. This paper describes the barriers and drivers and options to optimize this acceptance process as identified by two expert panels, one on pharmaceuticals and one on chemicals. To untangle the complex acceptance process, the multilevel perspective on technology transitions is applied. This perspective defines influences at the micro-, meso- and macro level which need alignment to induce regulatory acceptance of a 3R model. This paper displays that there are many similar mechanisms within both sectors that prevent 3R models from becoming accepted for regulatory risk assessment and management. Shared barriers include the uncertainty about the value of the new 3R models (micro level), the lack of harmonization of regulatory requirements and acceptance criteria (meso level) and the high levels of risk aversion (macro level). In optimizing the process commitment, communication, cooperation and coordination are identified as critical drivers. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Analysis on the public acceptance of nuclear energy using structural equation model with latent variables

    International Nuclear Information System (INIS)

    Lee, Young Eal

    1996-02-01

    Comparison of the effect of education and public information on the public acceptance of nuclear energy is carried out. For the increase of public acceptance, the correct understanding on the nuclear energy via proper regular school education would be the first basis and the appropriate public information services by utility and unbiased mass media would be the second basis. Subjects that which is more effect in education or information and how much effective quantitatively to improve the public acceptance are derived. Structural Equation Model (SEM) with Latent Variables (LVs) in social science to public attitudes towards nuclear energy is developed. Questionnaire is conducted to respondents who took part in the program of visiting the nuclear power plant opened by OKAEA in 1995. As a result of the analysis, effect of education for correct awareness of nuclear energy is more sensitive to public acceptance than that of information. It is shown that the susceptibility in education factor in influence of radiation on human body and that in information factor persons consider nuclear power plant as an environmental polluter. It is concluded that radiation treatment should be a 'Hand on Experience' and general principle of nuclear power generation should be contained in the educational text book. Education and information should not been independently performed but been carried out simultaneously and mutually aided. It is shown that this modeling approach is useful to make the decision for the long-term nuclear energy policy transparent and successful

  7. Implementation, availability and regulatory status of an OECD accepted Reconstructed Human Epidermis model in Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo De Vecchi

    2018-02-01

    Full Text Available Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019. As a result, the interest for validated alternative testing methods for safety assessment has been increasing in academia, industry and associations. However, the lack of specific legislation on the use of biological material of human origin for toxicological tests makes the access to alternative in vitro models difficult. Furthermore, importation to Brazil is not possible on timely manner. Method: In this article, we report the implementation process of a Reconstructed Human Epidermis (SkinEthic™ RHE, an alternative model internationally accepted by OECD, through a technology transfer from EPISKIN® Lyon to Brazil. Regulatory evolution has been motivating the implementation and wide use of alternative methods to animal testing in several industry segments including cosmetic and pharmaceutical. Results: Protocol has been shown to be robust and highly reproducible. Quality control parameters (histological analysis, barrier function test and tissue viability were performed on 24 batches assembled in Brazil. SkinEthic™ RHE model use allows the full replacement of animal test methods for skin hazards identification. It has regulatory acceptance for several toxicological endpoints, such as the Draize test for skin irritation and corrosion. It allows the reduction and refining of pre-clinical protocols through tiered strategies. Implementation of SkinEthic™ RHE protocol is just a first and important step towards a new approach of toxicological safety testing in Brazil. Conclusion: The implementation was successfully done and reported here. However, in order to follow completely the new legislation up to 2019, the availability of validated models is essential. Quality control tests done on RHE batches produced in Brazil demonstrate that the model met OECD acceptance

  8. Penerimaan Sistem Informasi Akuntansi pada Pusat Kesehatan Masyarakat yang Baru Menjadi Badan Layanan Umum Daerah (BLUD)

    OpenAIRE

    Suryanto, Rudy; Latif, Mohamad Abdul; Sofyani, Hafiez

    2017-01-01

    This study aims to analyze the acceptance of public service agency (BLUD) accounting information system at BLUD health center in Boyolali, Center Java. TAM model is used in this study with behavioral theory perspective that used to for examine information technology adopted process. The samples used in this research is accounting and financial staffs at BLUD health center in Java that using BLUD accounting information system that developed by PT. Syncore Indonesia. Data obtained from question...

  9. Understanding the determinants of hotel booking intentions and moderating role of habit

    OpenAIRE

    El-Masry, AA; Agag, G

    2016-01-01

    When there are more and more online hotel consumers, it is important for industry players to know why consumers prefer one online booking channel among others. Grounded in the commitment–trust theory (KMV) and the Technology Acceptance Model (TAM), this paper seeks to develop and empirically test a comprehensive framework to examine which factors influence consumer intentions to book hotel online. Using SEM to analyse the data collected from a sample of 1431 Internet users, the results indica...

  10. VIRTUAL PURCHASE INTENTION: INFLUENCE OF SECURITY AND TRUST

    OpenAIRE

    Asma javed*, Dr Wasif Ali Waseer, Dr Babak Mehmood

    2018-01-01

    The fast growth of online transaction and e-commerce inspired many companies to setup their business on web pages. It is fact that online purchasing is still poor as compared to other online activities. Research study will explore factors that affect consumer’s virtual purchase intention. Theory of Planned Behavior (TPB), Theory of Reasoned Action (TRA), and Theory Acceptance Model (TAM) are the groundwork theories that are used in research to investigate those factors that affect the virtual...

  11. Diffusion and Large-Scale Adoption of Computer-Supported Training Simulations in the Military Domain

    Science.gov (United States)

    2013-09-01

    SVET Submerged Vehicle Egress Trainer SWET Shallow Water Egress Trainer TAM Technology Acceptance Model TCP Transmission Control Protocol TEEP...metaphor for food and water , firearms and training, and medical supplies and first aid knowledge), logistical costs (transportation, fuel, and...too long to build new scenarios # 6 3 4 0 % 2.00 4.35 8.70 0.00 Lack of availabilit y when needed # 0 4 0 0 % 0.00 5.80 0.00 0.00 No

  12. Csapody, Tamás. 2014. Bortól Szombathelyig - Tanulmányok a bori munkaszolgálatról és a bori munkaszolgálatosok részleges névlistája ('From Bor to Szombathely- Studies on the Forced Labor Service at Bor Camp and the Partial List of the Forced Laborers in Bor'. Budapest: Zrinyi Kadó. 254 pp. ; Csapody, Tamás. 2015. A Cservenkai tömeggyilkosság ('The Mass Murder at Cservenka'. Budapest: Zsidó Tudományok Szabadegyeteme Alapítvány. 150 pp.

    Directory of Open Access Journals (Sweden)

    Julia Bock

    2016-10-01

    Full Text Available Csapody, Tamás. 2014. Bortól Szombathelyig - Tanulmányok a bori munkaszolgálatról és a bori munkaszolgálatosok részleges névlistája ('From Bor to Szombathely- Studies on the Forced Labor Service at Bor Camp and the Partial List of the Forced Laborers in Bor'. Budapest: Zrinyi Kadó. 254 pp. ; Csapody, Tamás. 2015. A Cservenkai tömeggyilkosság ('The Mass Murder at Cservenka'. Budapest: Zsidó Tudományok Szabadegyeteme Alapítvány. 150 pp. (e-book; a shorter version is accessible at: http://zsido.com/konyvek/a-cservenkai-tomeggyilkossag/.

  13. Risk Acceptance Criteria and/or Decision optimization

    DEFF Research Database (Denmark)

    Ditlevsen, Ove Dalager

    1996-01-01

    Acceptance criteria applied in practical risk analysis are recapitulated including the concept of rist profile. Modelling of risk profiles is illustrated on the basis of compound Poisson process models. The current practice of authoritative acceptance criteria formulation is discussed from...... a decision theoretical point of view. It is argued that the phenomenon of risk aversion rather than being of concern to the authority should be of concern to the owner. Finally it is discussed whether there is an ethical problem when formally capitalising human lives with a positive interest rate. Keywords......: Risk acceptance, Risk profile, Compound Poisson model for risk profile, Capitalization of human life, Risk aversion....

  14. A Proposed Framework to Understand the Intrinsic Motivation Factors on University Students’ Behavioral Intention to Use a Mobile Application for Learning

    Directory of Open Access Journals (Sweden)

    Ronnie H. Shroff

    2017-04-01

    Full Text Available Aim/Purpose: By integrating a motivational perspective into the Technology Acceptance Model, the goal of this study is to empirically test the causal relationship of intrinsic motivational factors on students’ behavioral intention to use (BIU a mobile application for learning. Background:\tAlthough the Technology Acceptance Model is a significant model, it largely remains incomplete as it does not take into consideration the motivation factors and/or outside influences in the adoption of new technology. Methodology: A Mobile Application Motivation Instrument (MAMI was developed from a comprehensive review of literature on intrinsic motivation and verified using a formalized card sorting procedure. Four intrinsic motivation scales were developed: perceived competence (COM, perceived challenge (CHA, perceived choice (CHO, and perceived interest (INT. Consequently, a scale to assess students’ behavioral intention (BIU to use mobile applications was developed using existing scales from prior TAM instruments. Contribution: Incorporating the motivational factors into TAM may provide better explanation and prediction of student acceptance and usage of mobile applications. A potential contribution of this study is the development of a reliable and valid instrument that could be further used by a growing community of researchers, instructional designers, and instructors. Findings: Data were collected from 193 participants to test the causal relationship of perceived competence (COM, perceived challenge (CHA, perceived choice (CHO, and perceived interest (INT on students’ behavioral intention to use (BIU a mobile application, using a structural equation modeling approach. The structural path model indicated that perceived competence (COM, perceived challenge (CHA, perceived choice (CHO, and perceived interest (INT had a significant influence on students’ behavioral intention to use (BIU a mobile application for learning. Implications of this study

  15. Public Claims about Automatic External Defibrillators: An Online Consumer Opinions Study

    Directory of Open Access Journals (Sweden)

    Barnett Julie

    2011-05-01

    Full Text Available Abstract Background Patients are no longer passive recipients of health care, and increasingly engage in health communications outside of the traditional patient and health care professional relationship. As a result, patient opinions and health related judgements are now being informed by a wide range of social, media, and online information sources. Government initiatives recognise self-delivery of health care as a valuable means of responding to the anticipated increased global demand for health resources. Automated External Defibrillators (AEDs, designed for the treatment of Sudden Cardiac Arrest (SCA, have recently become available for 'over the counter' purchase with no need for a prescription. This paper explores the claims and argumentation of lay persons and health care practitioners and professionals relating to these, and how these may impact on the acceptance, adoption and use of these devices within the home context. Methods We carry out a thematic content analysis of a novel form of Internet-based data: online consumer opinions of AED devices posted on Amazon.com, the world's largest online retailer. A total of #83 online consumer reviews of home AEDs are analysed. The analysis is both inductive, identifying themes that emerged from the data, exploring the parameters of public debate relating to these devices, and also driven by theory, centring around the parameters that may impact upon the acceptance, adoption and use of these devices within the home as indicated by the Technology Acceptance Model (TAM. Results Five high-level themes around which arguments for and against the adoption of home AEDs are identified and considered in the context of TAM. These include opinions relating to device usability, usefulness, cost, emotional implications of device ownership, and individual patient risk status. Emotional implications associated with AED acceptance, adoption and use emerged as a notable factor that is not currently reflected

  16. Public claims about automatic external defibrillators: an online consumer opinions study.

    Science.gov (United States)

    Money, Arthur G; Barnett, Julie; Kuljis, Jasna

    2011-05-18

    Patients are no longer passive recipients of health care, and increasingly engage in health communications outside of the traditional patient and health care professional relationship. As a result, patient opinions and health related judgements are now being informed by a wide range of social, media, and online information sources. Government initiatives recognise self-delivery of health care as a valuable means of responding to the anticipated increased global demand for health resources. Automated External Defibrillators (AEDs), designed for the treatment of Sudden Cardiac Arrest (SCA), have recently become available for 'over the counter' purchase with no need for a prescription. This paper explores the claims and argumentation of lay persons and health care practitioners and professionals relating to these, and how these may impact on the acceptance, adoption and use of these devices within the home context. We carry out a thematic content analysis of a novel form of Internet-based data: online consumer opinions of AED devices posted on Amazon.com, the world's largest online retailer. A total of #83 online consumer reviews of home AEDs are analysed. The analysis is both inductive, identifying themes that emerged from the data, exploring the parameters of public debate relating to these devices, and also driven by theory, centring around the parameters that may impact upon the acceptance, adoption and use of these devices within the home as indicated by the Technology Acceptance Model (TAM). Five high-level themes around which arguments for and against the adoption of home AEDs are identified and considered in the context of TAM. These include opinions relating to device usability, usefulness, cost, emotional implications of device ownership, and individual patient risk status. Emotional implications associated with AED acceptance, adoption and use emerged as a notable factor that is not currently reflected within the existing TAM. The value, credibility and

  17. Integrating User Interface and Personal Innovativeness into the TAM for Mobile Learning in Cyber University

    Science.gov (United States)

    Joo, Young Ju; Lee, Hyeon Woo; Ham, Yookyoung

    2014-01-01

    This study aims to add new variables, namely user interface, personal innovativeness, and satisfaction in learning, to Davis's technology acceptance model and also examine whether learners are willing to adopt mobile learning. Thus, this study attempted to explain the structural causal relationships among user interface, personal…

  18. Degenerative Disease in an Aging Population Models and Conjectures

    NARCIS (Netherlands)

    J.J.M. Barendregt (Jan); L.G.A. Bonneux (Luc)

    1998-01-01

    textabstractThis PhD thesis is rootcd in a mnltidisciplinary project, ca lied Technology Assessment lvlethods (TAM). The (ambitious) aim of the TAM project was to develop a comprehcllsive method of evalnating medical tcchnology in the perspective of multiple risk factors, multiple diseascs and

  19. A Rentabilidade da TAM no Contexto de Elevação do Preço do Barril de Petróleo

    Directory of Open Access Journals (Sweden)

    Antônio Nunes Pereira

    2008-01-01

    Full Text Available The present study aims at evaluating the extent to which the international increase in petroleum price per barrel impacted the profitability of the Transportes Aéreos Marília S.A. (TAM airlines. The context of civil aviation is explored in the case study methodology, including DuPont Method and simple linear regression for the 2001-2006 period. The study attempts to falsify the hypothesis of no relationship between the increase in petroleum price per barrel and profitability. Apparently, the price of a barrel of petroleum influences TAM¿s ROA, ROE, Cost of Assets and Services, Operational Budget, and Net Profit, especially on quarterly bases (significance level: p < .05.

  20. Testing the Electronic Personal Health Record Acceptance Model by Nurses for Managing Their Own Health

    Science.gov (United States)

    Trinkoff, A.M.; Storr, C.L.; Wilson, M.L.; Gurses, A.P.

    2015-01-01

    Summary Background To our knowledge, no evidence is available on health care professionals’ use of electronic personal health records (ePHRs) for their health management. We therefore focused on nurses’ personal use of ePHRs using a modified technology acceptance model. Objectives To examine (1) the psychometric properties of the ePHR acceptance model, (2) the associations of perceived usefulness, ease of use, data privacy and security protection, and perception of self as health-promoting role models to nurses’ own ePHR use, and (3) the moderating influences of age, chronic illness and medication use, and providers’ use of electronic health record (EHRs) on the associations between the ePHR acceptance constructs and ePHR use. Methods A convenience sample of registered nurses, those working in one of 12 hospitals in the Maryland and Washington, DC areas and members of the nursing informatics community (AMIA and HIMSS), were invited to respond to an anonymous online survey; 847 responded. Multiple logistic regression identified associations between the model constructs and ePHR use, and the moderating effect. Results Overall, ePHRs were used by 47%. Sufficient reliability for all scales was found. Three constructs were significantly related to nurses’ own ePHR use after adjusting for covariates: usefulness, data privacy and security protection, and health-promoting role model. Nurses with providers that used EHRs who perceived a higher level of data privacy and security protection had greater odds of ePHR use than those whose providers did not use EHRs. Older nurses with a higher self-perception as health-promoting role models had greater odds of ePHR use than younger nurses. Conclusions Nurses who use ePHRs for their personal health might promote adoption by the general public by serving as health-promoting role models. They can contribute to improvements in patient education and ePHR design, and serve as crucial resources when working with their

  1. Modeling eBook acceptance: A study on mathematics teachers

    Science.gov (United States)

    Jalal, Azlin Abd; Ayub, Ahmad Fauzi Mohd; Tarmizi, Rohani Ahmad

    2014-12-01

    The integration and effectiveness of eBook utilization in Mathematics teaching and learning greatly relied upon the teachers, hence the need to understand their perceptions and beliefs. The eBook, an individual laptop completed with digitized textbook sofwares, were provided for each students in line with the concept of 1 student:1 laptop. This study focuses on predicting a model on the acceptance of the eBook among Mathematics teachers. Data was collected from 304 mathematics teachers in selected schools using a survey questionnaire. The selection were based on the proportionate stratified sampling. Structural Equation Modeling (SEM) were employed where the model was tested and evaluated and was found to have a good fit. The variance explained for the teachers' attitude towards eBook is approximately 69.1% where perceived usefulness appeared to be a stronger determinant compared to perceived ease of use. This study concluded that the attitude of mathematics teachers towards eBook depends largely on the perception of how useful the eBook is on improving their teaching performance, implying that teachers should be kept updated with the latest mathematical application and sofwares to use with the eBook to ensure positive attitude towards using it in class.

  2. "Like Holding an Umbrella Before It Rains": Acceptability of Future Rectal Microbicides Among Men Who Have Sex With Men in India-A Modified Technology Acceptance Model.

    Science.gov (United States)

    Chakrapani, Venkatesan; Newman, Peter A; Shunmugam, Murali; Mengle, Shruta; Nelson, Ruban; Rubincam, Clara; Kumar, Pushpesh

    2017-07-01

    Topical rectal microbicides (RMs) are a new prevention technology in development that aims to reduce the risk of HIV acquisition from anal sex. We examined RM acceptability among men who have sex with men (MSM) in India. We conducted a qualitative exploratory study guided by a modified Technology Acceptance Model, with 10 focus groups ( n = 61) of MSM and 10 key informant interviews. Data were explored using framework analysis. RM acceptability was influenced by technological contexts: perceived usefulness of RMs, perceived ease of use of RM and applicator, and habits around condom and lubricant use; individual and interpersonal contexts: perceived relevance and preferences for product formulation and dosing frequency; and MSM community/social contexts: perceived social approval, RM-related stigma, social support. Implementation of RMs for MSM in India may be supported by multi-level interventions that engage community-based organizations in destigmatizing and distributing RMs, ideally gel-based products that enable on-demand use before sex.

  3. Coppers context, and conjoints: a reassessment of TAM

    NARCIS (Netherlands)

    Bouwman, Harry; van de Wijngaert, Lidwien

    2009-01-01

    This study examines the role and explanatory value of context-, task- and information-related characteristics vis-a-vis individual characteristics in relation with respect to the adoption of mobile technologies and applications. We combine insights from adoption and acceptance literature with media

  4. Flood Prediction for the Tam Nong District in Mekong Delta Using Hydrological Modelling and Hydrologic Remote Sensing Technique

    Science.gov (United States)

    Kappas, Martin; Nguyen Hong, Quang; Thanh, Nga Pham Thi; Thu, Hang Le Thi; Nguyen Vu, Giang; Degener, Jan; Rafiei Emam, Ammar

    2017-04-01

    There has been an increasing attention to the large trans-boundary Mekong river basin due to various problems related to water management and flood control, for instance. Vietnam Mekong delta is located at the downstream of the river basin where is affected most by this human-induced reduction in flows from the upstream. On the other hand, the flood plain of nine anastomosing channels is increasingly effected by the seawater intrusion due to sea level rising of climate change. This results in negative impacts of salinization, drought, and floods, while formerly flooding had frequently brought positive natural gain of irrigation water and alluvial aggradation. In this research, our aim is to predict flooding for the better water management adaptation and control. We applied the model HEC-SSP 2.1 to analyze flood flow frequency, two-dimensional unsteady flow calculations in HEC-RAS 5.0 for simulating a floodplain inundation. Remote sensing-based water level (Jason-2) and inundation map were used for validation and comparison with the model simulations. The results revealed a reduction of water level at all the monitoring stations, particularly in the last decade. In addition, a trend of the inundation extension gradually declined, but in some periods it remained severe due to water release from upstream reservoirs during the rainy season (October-November). We found an acceptable agreement between the HEC-RAS and remote sensing flooding maps (around 70%). Based on the flood routine analysis, we could conclude that the water level will continue lower and lead to a trend of drought and salinization harsher in the near future. Keywords: Mekong delta, flood control, inundation, water management, hydrological modelling, remote sensing

  5. DAİRESEL DALGA KILAVUZLARININ OPTİMİZE EDİLMİŞ İLETİM HATTI MATRİS MODELİ İLE TAM DALGA ANALİZİ

    Directory of Open Access Journals (Sweden)

    Ayhan AKBAL

    2013-05-01

    Full Text Available Düşük firekaslarda kullanılan yaklaşımlar yüksek frekanslarda geçerli olmadığında analizde tam-dalga yöntemlerinin kullanılması bir zorunluluktur. İletim Hattı Matrisi Modeli (TLM bir tam-dalga analiz yöntemi olup literatürde elektromanyetik olayların analizinde sıklıkla kullanılmaktadır. Ancak bu modelde sınır şartlarından kaynaklanan yansıma, aşma, üst üste binme, bozulma, sinyal bütünlüğünün bozulması gibi çeşitli problemler ile karşılaşılmaktadır. Bu çalışmada TLM yönteminde sınır şartlarının kolay uygulanabilmesi için optimizasyon yapılmıştır. Optimizasyonun başarısını göstermek içinde örnek olarak analizi daha komplex olan dairesel dalga klavusu kullanılmıştır. Bu yayında X bandında (8-12 GHz kullanılan WC-94 adlı dairesel dalga kılavuzu TE ve TM modu için ayrı ayrı, optimize edilmiş TLM yöntemi ile analiz edilmiştir. Sonuçların doğrulugu ve sunulan optimizasyon yönteminin başarısı ayrıntıları ile sunulmuştur.

  6. Predicting the Use of Instructional Technology among Community College Instructors: An Extension of the Technology Acceptance Model (TAM)

    Science.gov (United States)

    Miller, Emma Rebecca

    2017-01-01

    The purpose of this study was to determine what variables predict the use of instructional technology among community college instructors. Legislators, community college administrators, and students expect innovative lessons from instructors that use technology. This study addresses the problem of not knowing what predicts instructional technology…

  7. Antecedents to Consumers' Acceptance of Mobile Advertisements

    DEFF Research Database (Denmark)

    Rajala, Risto; Westerlund, Mika

    2010-01-01

    The paper presents a hierarchical construct PLS structural equation model to analyze mobile advertisement acceptance. Hypotheses are established and tested about the hierarchical structure and the effects of the factors that precede consumers' behavioral intention to accept mobile advertisement....... The results suggest that valuable content and trust in advertisers are key predictors of mobile device users' acceptance of mobile advertising. In addition, subjective value of the ads and subjective norms mediate these antecedent-acceptance relationships. The results are invaluable to both scholars...

  8. Analisi terminologica dei siti web delle Compagnie Aeree British Airways, Alitalia, Tam e LAN

    Directory of Open Access Journals (Sweden)

    Claudia Maria Astorino

    2012-02-01

    Full Text Available This study is part of a research about the terminology found in the language of tourism, defined as an area of ??knowledge. It has been conducted a study based upon the terms used by four major international airlines - two from Europe: British Airways (United Kingdom and Alitalia (Italy, and two from Latin America: TAM (Brazil and Lan (Chile - in their websites, designed for the final consumer (passenger, since each of them has a different official language (English, Italian, Portuguese and Spanish, respectively. The specific objectives were: i to reflect about the differences among the terms used by each airline, ii to analyze whether there is a substantial presence of acronyms, iii to identify how each of these airlines use English, considering that only the first one has it as its official language. The hypothesis that have guided the research are: i there are no significant changes among the terminology used by the airlines which are the object of the present research, ii, there is a fair use of synonyms for the same concepts, iii there is an extensive use of acronyms, iv there is a considerable influence of English, that may be seen in language borrowings and in some hybrid formations.

  9. An Elaboration Likelihood Model Based Longitudinal Analysis of Attitude Change during the Process of IT Acceptance via Education Program

    Science.gov (United States)

    Lee, Woong-Kyu

    2012-01-01

    The principal objective of this study was to gain insight into attitude changes occurring during IT acceptance from the perspective of elaboration likelihood model (ELM). In particular, the primary target of this study was the process of IT acceptance through an education program. Although the Internet and computers are now quite ubiquitous, and…

  10. Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells.

    Science.gov (United States)

    Kim, Sangmin; Lee, Jeongmin; Oh, Soo Jin; Nam, Seok Jin; Lee, Jeong Eon

    2015-09-01

    Although tamoxifen is the most common and effective therapy for treatment of estrogen receptor-α (ER-α) breast cancer patients, resistance of endocrine therapy occurs, either de novo or acquired during therapy. Here, we investigated the clinical value of epidermal growth factor receptor (EGFR) in tamoxifen-resistant (TamR) patients and the differential effect of EGFR inhibitors, neratinib and gefitinib, on TamR breast cancer cell model. The morphology of TamR MCF7 cells showed mesenchymal phenotypes and did not induce cell death by tamoxifen treatment compared with tamoxifen‑sensitive (TamS) MCF7 cells. In addition, mesenchymal marker proteins, including N-cadherin (N-cad), fibronectin (FN), and Slug, significantly increased in TamR cells. In contrast, ER-α and E-cadherin (E-cad) were greatly decreased. We also found that the levels of EGFR and HER2 expression were increased in TamR cells. Furthermore, we observed that EGFR expression was directly involved with poor prognosis of tamoxifen-treated breast cancer patients using the GSE1378 date set. Thus, we treated TamR and TamS cells with EGFR inhibitors, neratinib and gefitinib, respectively. Interestingly, neratinib induced apoptotic cell death of TamR but not gefitinib. Cleaved PARP-1 expression was also increased by neratinib treatment in TamR cells. Therefore, we suggest that neratinib may be a potential therapeutic drug for treating TamR breast cancer.

  11. User acceptance of mobile health services from users' perspectives: The role of self-efficacy and response-efficacy in technology acceptance.

    Science.gov (United States)

    Zhang, Xiaofei; Han, Xiaocui; Dang, Yuanyuan; Meng, Fanbo; Guo, Xitong; Lin, Jiayue

    2017-03-01

    With the swift emergence of electronic medical information, the global popularity of mobile health (mHealth) services continues to increase steadily. This study aims to investigate the efficacy factors that directly or indirectly influence individuals' acceptance of mHealth services. Based on the technology acceptance model, this research incorporates efficacy factors into the acceptance decision process. A research model was proposed involving the direct and indirect effects of self-efficacy and response-efficacy on acceptance intention, along with their moderating effects. The model and hypotheses were validated using data collected from a field survey of 650 potential service users. The results reveal that: (1) self-efficacy and response-efficacy are both positively associated with perceived ease of use; and (2) self-efficacy and response-efficacy moderate the impact of perceived usefulness toward adoption intention. Self-efficacy and response-efficacy both play an important role in individuals' acceptance of mHealth services, which not only affect their perceived ease of use of mHealth services, but also positively moderate the effects of perceived usefulness on adoption intention. Our findings serve to provide recommendations that are specifically customized for mHealth service providers and their marketers.

  12. Measuring the Moderating Effect of Gender and Age on E-Learning Acceptance in England: A Structural Equation Modeling Approach for an Extended Technology Acceptance Model

    Science.gov (United States)

    Tarhini, Ali; Hone, Kate; Liu, Xiaohui

    2014-01-01

    The success of an e-learning intervention depends to a considerable extent on student acceptance and use of the technology. Therefore, it has become imperative for practitioners and policymakers to understand the factors affecting the user acceptance of e-learning systems in order to enhance the students' learning experience. Based on an extended…

  13. Key factors of teenagers' mobile advertising acceptance

    OpenAIRE

    Martí Parreño, José; Sanz Blas, Silvia; Ruiz Mafé, Carla; Aldás Manzano, Joaquín

    2013-01-01

    Purpose – The purpose of this paper is to analyse key drivers of teenagers’ attitude toward mobile advertising and its effects on teenagers’ mobile advertising acceptance. Design/methodology/approach – A proposed model of affective (irritation and entertainment) and cognitive (perceived usefulness) antecedents of attitude toward mobile advertising and its effects on mobile advertising acceptance is analysed. The sample consisted of 355 Spanish teenagers. The model was tested us...

  14. A novel framework for analysing stakeholder interest in healthy foods: A case study on iodine biofortification.

    Science.gov (United States)

    Mogendi, Joseph Birundu; De Steur, Hans; Gellynck, Xavier; Makokha, Anselimo

    2016-01-01

    Despite the availability of novel strategies to prevent micronutrient malnutrition, such as biofortification, limited understanding of stakeholders often hampers their success. We build upon the existing literature on protection motivations (PMT) and technology acceptance (TAM) to develop an integrated PMTAM model for analyzing stakeholders' reactions, on both the supply and demand sides. Regarding the latter, the case of the iodine biofortified food chain is used to evaluate African households' interest. All model constructs, and threat appraisal in particular, are decisive in determining the uptake of biofortification, while also social demographics and own nutrition status play an important role.

  15. Empirical Testing of a Theoretical Extension of the Technology Acceptance Model: An Exploratory Study of Educational Wikis

    Science.gov (United States)

    Liu, Xun

    2010-01-01

    This study extended the technology acceptance model and empirically tested the new model with wikis, a new type of educational technology. Based on social cognitive theory and the theory of planned behavior, three new variables, wiki self-efficacy, online posting anxiety, and perceived behavioral control, were added to the original technology…

  16. Learning with Interactive Whiteboards: Determining the Factors on Promoting Interactive Whiteboards to Students by Technology Acceptance Model

    Science.gov (United States)

    Kilic, Eylem; Güler, Çetin; Çelik, H. Eray; Tatli, Cemal

    2015-01-01

    Purpose: The purpose of this study is to investigate the factors which might affect the intention to use interactive whiteboards (IWBs) by university students, using Technology Acceptance Model by the structural equation modeling approach. The following hypothesis guided the current study: H1. There is a positive relationship between IWB…

  17. Factors Affecting Intention to Use in Social Networking Sites: An Empirical Study on Thai Society

    Science.gov (United States)

    Jairak, Rath; Sahakhunchai, Napath; Jairak, Kallaya; Praneetpolgrang, Prasong

    This research aims to explore the factors that affect the intention to use in Social Networking Sites (SNS). We apply the theory of Technology Acceptance Model (TAM), intrinsic motivation, and trust properties to develop the theoretical framework for SNS users' intention. The results show that the important factors influencing SNS users' intention for general purpose and collaborative learning are task-oriented, pleasure-oriented, and familiarity-based trust. In marketing usage, dispositional trust and pleasure-oriented are two main factors that reflect intention to use in SNS.

  18. Understanding Retailers’ Acceptance of Virtual Stores

    Directory of Open Access Journals (Sweden)

    Irene Y.L. Chen

    2010-09-01

    Full Text Available The acceptance of e-commerce among consumers has stimulated the rise of virtual stores. Increasing traditional retailers or people who do not have sufficient capital for maintaining a brick-and-mortar store have considered using virtual stores to reach global market. In the e-commerce literature, there has been rich research evidence concerning consumers’ acceptance of virtual stores. However, rigorous academic research on retailers’ acceptance of virtual stores is relatively scarce today. This study draws upon the theory of planned behavior and information richness theory to propose an integrated theoretical model. A field survey is used to collect data from e-tailers. The data are analyzed to examine the six relationships posited in the research model. Findings of this study provide a further research avenue for e-commerce, and implications for those who are managing or considering using virtual stores.

  19. EVALUATION OF THE INTENTION OF USING PRODUCTS WITH INTERNET OF THINGS WITHIN THE CONTEXT OF TECHNOLOGY ACCEPTANCE MODEL

    OpenAIRE

    Pazvant, Ece; Faiz, Emel

    2018-01-01

    Purpose-  Developments in information technology anddigital arena have opened the way for many new applications that willfacilitate everyday life. It is important for producers to know the reasonsbehind acceptance, use and rejection of these new applications. The purpose ofthis study is to examine the basic factors behind the intention of usingproducts with internet of things technology that are new to our life within thetechnology acceptance model.   Methodology- TheMultiple Regression Analy...

  20. Acceptance sampling using judgmental and randomly selected samples

    Energy Technology Data Exchange (ETDEWEB)

    Sego, Landon H.; Shulman, Stanley A.; Anderson, Kevin K.; Wilson, John E.; Pulsipher, Brent A.; Sieber, W. Karl

    2010-09-01

    We present a Bayesian model for acceptance sampling where the population consists of two groups, each with different levels of risk of containing unacceptable items. Expert opinion, or judgment, may be required to distinguish between the high and low-risk groups. Hence, high-risk items are likely to be identifed (and sampled) using expert judgment, while the remaining low-risk items are sampled randomly. We focus on the situation where all observed samples must be acceptable. Consequently, the objective of the statistical inference is to quantify the probability that a large percentage of the unsampled items in the population are also acceptable. We demonstrate that traditional (frequentist) acceptance sampling and simpler Bayesian formulations of the problem are essentially special cases of the proposed model. We explore the properties of the model in detail, and discuss the conditions necessary to ensure that required samples sizes are non-decreasing function of the population size. The method is applicable to a variety of acceptance sampling problems, and, in particular, to environmental sampling where the objective is to demonstrate the safety of reoccupying a remediated facility that has been contaminated with a lethal agent.

  1. Grammaticality, Acceptability, and Probability: A Probabilistic View of Linguistic Knowledge.

    Science.gov (United States)

    Lau, Jey Han; Clark, Alexander; Lappin, Shalom

    2017-07-01

    The question of whether humans represent grammatical knowledge as a binary condition on membership in a set of well-formed sentences, or as a probabilistic property has been the subject of debate among linguists, psychologists, and cognitive scientists for many decades. Acceptability judgments present a serious problem for both classical binary and probabilistic theories of grammaticality. These judgements are gradient in nature, and so cannot be directly accommodated in a binary formal grammar. However, it is also not possible to simply reduce acceptability to probability. The acceptability of a sentence is not the same as the likelihood of its occurrence, which is, in part, determined by factors like sentence length and lexical frequency. In this paper, we present the results of a set of large-scale experiments using crowd-sourced acceptability judgments that demonstrate gradience to be a pervasive feature in acceptability judgments. We then show how one can predict acceptability judgments on the basis of probability by augmenting probabilistic language models with an acceptability measure. This is a function that normalizes probability values to eliminate the confounding factors of length and lexical frequency. We describe a sequence of modeling experiments with unsupervised language models drawn from state-of-the-art machine learning methods in natural language processing. Several of these models achieve very encouraging levels of accuracy in the acceptability prediction task, as measured by the correlation between the acceptability measure scores and mean human acceptability values. We consider the relevance of these results to the debate on the nature of grammatical competence, and we argue that they support the view that linguistic knowledge can be intrinsically probabilistic. Copyright © 2016 Cognitive Science Society, Inc.

  2. Influence Processes for Information Technology Acceptance

    DEFF Research Database (Denmark)

    Bhattacherjee, Anol; Sanford, Clive Carlton

    2006-01-01

    This study examines how processes of external influence shape information technology acceptance among potential users, how such influence effects vary across a user population, and whether these effects are persistent over time. Drawing on the elaboration-likelihood model (ELM), we compared two...... alternative influence processes, the central and peripheral routes, in motivating IT acceptance. These processes were respectively operationalized using the argument quality and source credibility constructs, and linked to perceived usefulness and attitude, the core perceptual drivers of IT acceptance. We...... further examined how these influence processes were moderated by users' IT expertise and perceived job relevance and the temporal stability of such influence effects. Nine hypotheses thus developed were empirically validated using a field survey of document management system acceptance at an eastern...

  3. Fast Acceptance by Common Experience

    Directory of Open Access Journals (Sweden)

    Nathan Berg

    2010-08-01

    Full Text Available Schelling (1969, 1971a,b, 1978 observed that macro-level patterns do not necessarily reflect micro-level intentions, desires or goals. In his classic model on neighborhood segregation which initiated a large and influential literature, individuals with no desire to be segregated from those who belong to other social groups nevertheless wind up clustering with their own type. Most extensions of Schelling's model have replicated this result. There is an important mismatch, however, between theory and observation, which has received relatively little attention. Whereas Schelling-inspired models typically predict large degrees of segregation starting from virtually any initial condition, the empirical literature documents considerable heterogeneity in measured levels of segregation. This paper introduces a mechanism that can produce significantly higher levels of integration and, therefore, brings predicted distributions of segregation more in line with real-world observation. As in the classic Schelling model, agents in a simulated world want to stay or move to a new location depending on the proportion of neighbors they judge to be acceptable. In contrast to the classic model, agents' classifications of their neighbors as acceptable or not depend lexicographically on recognition first and group type (e.g., ethnic stereotyping second. The FACE-recognition model nests classic Schelling: When agents have no recognition memory, judgments about the acceptability of a prospective neighbor rely solely on his or her group type (as in the Schelling model. A very small amount of recognition memory, however, eventually leads to different classifications that, in turn, produce dramatic macro-level effects resulting in significantly higher levels of integration. A novel implication of the FACE-recognition model concerns the large potential impact of policy interventions that generate modest numbers of face-to-face encounters with members of other social groups.

  4. 40 CFR 600.007-80 - Vehicle acceptability.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Vehicle acceptability. 600.007-80... FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year Automobiles-General Provisions § 600.007-80 Vehicle acceptability. (a) All...

  5. 40 CFR 600.007-08 - Vehicle acceptability.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Vehicle acceptability. 600.007-08... FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year Automobiles-General Provisions § 600.007-08 Vehicle acceptability. (a) All...

  6. Juros sobre capital próprio: um estudo da economia tributária nas empresas Gol e Tam

    Directory of Open Access Journals (Sweden)

    Sérgio Murilo Petri

    2013-11-01

    Full Text Available Esta pesquisa tem como objetivo evidenciar a economia tributária obtida pelas empresas de transporte aéreo GOL e TAM por meio da utilização dos juros sobre capital próprio como remuneração ao acionista. Para isso, foi realizada uma pesquisa descritiva das empresas de transporte aéreo listadas na BM&FBOVESPA. Para a condução do estudo, foi realizada uma pesquisa documental de caráter quantitativo e qualitativo. Pelos resultados obtidos, pôde-se perceber que a remuneração aos acionistas por meio dos juros sobre capital próprio resultou em uma economia tributária de aproximadamente R$ 112,7 milhões nas duas empresas analisadas entre 2006 e 2010. Além disso, ficou evidenciado que as empresas de transporte aéreo analisadas têm adotado a prática de remuneração utilizando os juros sobre capital próprio, havendo a GOL, em 2009 e 2010, e a TAM, em 2010, optado por remunerar seus acionistas apenas por meio de dividendos obrigatórios, não ficando evidenciado em notas explicativas o motivo da decisão. Então, analisando o quadro societário e utilizando a distribuição dos JSCPs somente para as pessoas jurídicas, as empresas teriam economizado ainda R$ 56,906 milhões; distribuindo para as pessoas físicas sobre forma de dividendos por ser mais viável ao acionista, uma vez que não teriam o desconto de 15% do IR retido na fonte (pagando imposto de renda na pessoa física. Conclui-se, então, que o benefício fiscal dos JSCPs é relevante para as empresas, tendo em vista a economia tributária auferida com a utilização de tal benefício Fiscal do ente tributante. Entretanto, a empresa deve levar em consideração se o acionista é pessoa física (PF ou jurídica (PJ, pois para as PFs não é interessante a distribuição mediante os JSCPs uma vez que estes têm retenção de 15% de IR e com os dividendos não teriam de pagar imposto de renda na pessoa física.  

  7. Juros sobre capital próprio: um estudo da economia tributária nas empresas Gol e Tam

    Directory of Open Access Journals (Sweden)

    Sérgio Murilo Petri

    2013-07-01

    Full Text Available Esta pesquisa tem como objetivo evidenciar a economia tributária obtida pelas empresas de transporte aéreo GOL e TAM por meio da utilização dos juros sobre capital próprio como remuneração ao acionista. Para isso, foi realizada uma pesquisa descritiva das empresas de transporte aéreo listadas na BM&FBOVESPA. Para a condução do estudo, foi realizada uma pesquisa documental de caráter quantitativo e qualitativo. Pelos resultados obtidos, pôde-se perceber que a remuneração aos acionistas por meio dos juros sobre capital próprio resultou em uma economia tributária de aproximadamente R$ 112,7 milhões nas duas empresas analisadas entre 2006 e 2010. Além disso, ficou evidenciado que as empresas de transporte aéreo analisadas têm adotado a prática de remuneração utilizando os juros sobre capital próprio, havendo a GOL, em 2009 e 2010, e a TAM, em 2010, optado por remunerar seus acionistas apenas por meio de dividendos obrigatórios, não ficando evidenciado em notas explicativas o motivo da decisão. Então, analisando o quadro societário e utilizando a distribuição dos JSCPs somente para as pessoas jurídicas, as empresas teriam economizado ainda R$ 56,906 milhões; distribuindo para as pessoas físicas sobre forma de dividendos por ser mais viável ao acionista, uma vez que não teriam o desconto de 15% do IR retido na fonte (pagando imposto de renda na pessoa física. Conclui-se, então, que o benefício fiscal dos JSCPs é relevante para as empresas, tendo em vista a economia tributária auferida com a utilização de tal benefício Fiscal do ente tributante. Entretanto, a empresa deve levar em consideração se o acionista é pessoa física (PF ou jurídica (PJ, pois para as PFs não é interessante a distribuição mediante os JSCPs uma vez que estes têm retenção de 15% de IR e com os dividendos não teriam de pagar imposto de renda na pessoa física.

  8. Promiscuity and selectivity of small-molecule inhibitors across TAM receptor tyrosine kinases in pediatric leukemia.

    Science.gov (United States)

    Liu, Mao-Hua; Chen, Shi-Bing; Yu, Juan; Liu, Cheng-Jun; Zhang, Xiao-Jing

    2017-08-01

    The TAM receptor tyrosine kinase family member Mer has been recognized as an attractive therapeutic target for pediatric leukemia. Beside Mer the family contains other two kinases, namely, Tyro3 and Axl, which are highly homologues with Mer and thus most existing small-molecule inhibitors show moderate or high promiscuity across the three kinases. Here, the structural basis and energetic property of selective binding of small-molecule inhibitors to the three kinases were investigated at molecular level. It is found that the selectivity is primarily determined by the size, shape and configuration of kinase's ATP-binding site; the Mer and Axl possess a small, closed active pocket as compared to the bulky, open pocket of Tyro3. The location and conformation of active-site residues of Mer and Axl are highly consistent, suggesting that small-molecule inhibitors generally have a low Mer-over-Axl selectivity and a high Mer-over-Tyro3 selectivity. We demonstrated that the difference in ATP binding potency to the three kinases is also responsible for inhibitor selectivity. We also found that the long-range interactions and allosteric effect arising from rest of the kinase's active site can indirectly influence inhibitor binding and selectivity. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. User acceptance of mobile commerce: an empirical study in Macau

    Science.gov (United States)

    Lai, Ivan K. W.; Lai, Donny C. F.

    2014-06-01

    This study aims to examine the positive and negative factors that can significantly explain user acceptance of mobile commerce (m-commerce) in Macau. A technology acceptance model for m-commerce with five factors is constructed. The proposed model is tested using data collected from 219 respondents. Confirmatory factor analysis is performed to examine the reliability and validity of the model, and structural equation modelling is performed to access the relationship between behaviour intention and each factor. The acceptance of m-commerce is influenced by factors including performance expectancy, social influence, facilitating conditions and privacy concern; while effort expectancy is insignificant in this case. The results of the study are useful for m-commerce service providers to adjust their strategies for promoting m-commerce services. This study contributes to the practice by providing a user technology acceptance model for m-commerce that can be used as a foundation for future research.

  10. A Study of The Factors That Influence The Level of Consumer Satisfaction Towards The Use of Internet Banking

    Directory of Open Access Journals (Sweden)

    Vivi Vivi

    2017-10-01

    Full Text Available The development of Information and Communication Technology (ICT has become an integral part of people’s life today. Various kinds of business and trade transactions have changed along with the advancement of ICT. One of the sectors that are influenced by the development in information and communication technology is banking. The presence of internet banking has brought more conveniences to the customers in conducting banking transactions anytime and anywhere. However, one of the challenges faced by banks in implementing online banking is the security factor. In addition, consumer satisfaction in conducting internet transactions can be influenced by factors of Technology Acceptance Model (TAM. Technology Acceptance Model (TAM consists of perceived usefulness and perceived ease of use and excellent service from the provider. The purpose of this study is to determine whether security, perceived usefulness, perceived ease of use, and service quality havepositive influence on internet banking consumer satisfaction. Thetype of research is explanatory research type. The research variables consisting of independent variables are security factor, perceived usefulness, perceived ease of use, and service quality; meanwhile dependent variable is internet banking consumer satisfaction. The sampling technique used is accidental sampling method combined with snowball sampling method. Datais collected through questionnaires and interviews. Methods of data analysis used is Multiple Regression Analysis. The result shows that variables of  security, perceived usefulness, perceived ease of use, and service qualitysimultaneously influence internet banking consumer satisfaction. It shows that the four variables positively affect internet banking consumer satisfaction.

  11. Up-regulation of HOXB cluster genes are epigenetically regulated in tamoxifen-resistant MCF7 breast cancer cells.

    Science.gov (United States)

    Yang, Seoyeon; Lee, Ji-Yeon; Hur, Ho; Oh, Ji Hoon; Kim, Myoung Hee

    2018-05-28

    Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.

  12. Interactivity and Trust as Antecedents of E-Training Use Intention in Nigeria: A Structural Equation Modelling Approach.

    Science.gov (United States)

    Alkali, A U; Abu Mansor, Nur Naha

    2017-07-18

    The last few decades saw an intense development in information technology (IT) and it has affected the ways organisations achieve their goals. Training, in every organisation is an ongoing process that aims to update employees' knowledge and skills towards goals attainment. Through adequate deployment of IT, organisations can effectively meet their training needs. However, for successful IT integration in training, the employees who will use the system should be positively disposed towards it. This study predicts employees' intention to use the e-training system by extending the technology acceptance model (TAM) using interactivity and trust. Two hundred and fourteen employees participated in the study and structural equation modelling was used in the analysis. The findings of the structural equation modelling reveal that interactivity, trust, perceived usefulness and perceived ease of use have direct and positive effects on employees' intention to use e-training. It was also shown that perceived ease of use had no effects on perceived usefulness, while trust has the strongest indirect effects on employees' intention. In addition, the results of Importance-Performance Map Analysis (IPMA), which compares the contributions of each construct to the importance and performance of the model, indicate that to predict intention to use e-training, priorities should be accorded to trust and perceived usefulness.

  13. Perceived usefulness and perceived ease of use of electronic health records among nurses: Application of Technology Acceptance Model.

    Science.gov (United States)

    Tubaishat, Ahmad

    2017-09-18

    Electronic health records (EHRs) are increasingly being implemented in healthcare organizations but little attention has been paid to the degree to which nurses as end-users will accept these systems and subsequently use them. To explore nurses' perceptions of usefulness and ease-of-use of EHRs. The relationship between these constructs was examined, and its predictors were studied. A national exploratory study was conducted with 1539 nurses from 15 randomly selected hospitals, representative of different regions and healthcare sectors in Jordan. Data were collected using a self-administered questionnaire, which was based on the Technology Acceptance Model. Correlations and linear multiple regression were utilized to analyze the data. Jordanian nurses demonstrated a positive perception of the usefulness and ease-of-use of EHRs, and subsequently accepted the technology. Significant positive correlations were found between these two constructs. The variables that predict usefulness were the gender, professional rank, EHR experience, and computer skills of the nurses. The perceived ease-of-use was affected by nursing and EHR experience, and computers skills. This study adds to the growing body of knowledge on issues related to the acceptance of technology in the health informatics field, focusing on nurses' acceptance of EHRs.

  14. Minat Keperilakuan Individu Menggunakan Piranti Lunak sebagai Penunjang Pelaporan Keuangan

    Directory of Open Access Journals (Sweden)

    Narulita Rahmi Azriani

    2013-12-01

    Full Text Available This study examines determinant of behaviour intention using financial reporting software. The research combined Technology Acceptance Model (TAM and Theory of Planned Behaviour (TPB construct. Survey method was used to collect data and 141 questionnaires were distributed to the Bank Perkreditan Rakyat’s staff (BPR who operated financial reporting software. The results shows that intention to use software is positively affected by Perceived Ease of Use (PEU, Attitude, and Perceived Behaviour Control (PBC. While perceived usefulness and subjective norms do not influence individual behaviour intention.

  15. Preventing repetition of attempted suicide--I. Feasibility (acceptability, adherence, and effectiveness) of a Baerum-model like aftercare

    DEFF Research Database (Denmark)

    Hvid, Marianne; Wang, August G

    2009-01-01

    Repetition after attempted suicide is high with only limited research been put into effect studies. The Baerum-model from Norway offers a practical and affordable intervention. Our aim was to study the acceptability and effectiveness of a Baerum-model like intervention after attempted suicide using...... a quasi-experimental design. During a period in 2004, attempted suicide patients were offered follow-up care by a rapid-response outreach programme, an intervention lasting 6 months; a control group was established prospectively from a similar period in 2002. The design was an intent-to-treat analysis....... The outcome was measured by: 1) participation by acceptance and adherence, 2) repetition of suicide attempt and suicide, and 3) including the number of repetitive acts in 1 year after the attempted suicide episode. Follow-up period was 1 year. Participation was 70%. There was a significant lower repetition...

  16. Preventing repetition of attempted suicide-I. Feasibility (acceptability, adherence, and effectiveness) of a Baerum-model like aftercare

    DEFF Research Database (Denmark)

    Hvid, M.; Wang, August Gabriel

    2008-01-01

    Repetition after attempted suicide is high with only limited research been put into effect studies. The Baerum-model from Norway offers a practical and affordable intervention. Our aim was to study the acceptability and effectiveness of a Baerum-model like intervention after attempted suicide using...... a quasi-experimental design. During a period in 2004, attempted suicide patients were offered follow-up care by a rapid-response outreach programme, an intervention lasting 6 months; a control group was established prospectively from a similar period in 2002. The design was an intent-to-treat analysis....... The outcome was measured by: 1) participation by acceptance and adherence, 2) repetition of suicide attempt and suicide, and 3) including the number of repetitive acts in 1 year after the attempted suicide episode. Follow-up period was 1 year. Participation was 70%. There was a significant lower repetition...

  17. Factors of adoption of mobile information technology by homecare nurses: a technology acceptance model 2 approach.

    Science.gov (United States)

    Zhang, Huiying; Cocosila, Mihail; Archer, Norm

    2010-01-01

    Pervasive healthcare support through mobile information technology solutions is playing an increasing role in the attempt to improve healthcare and reduce costs. Despite the apparent attractiveness, many mobile applications have failed or have not been implemented as predicted. Among factors possibly leading to such outcomes, technology adoption is a key problem. This must be investigated early in the development process because healthcare is a particularly sensitive area with vital social implications. Moreover, it is important to investigate technology acceptance using the support of scientific tools validated for relevant information systems research. This article presents an empirical study based on the Technology Acceptance Model 2 in mobile homecare nursing. The study elicited the perceptions of 91 Canadian nurses who used personal digital assistants for 1 month in their daily activities. A partial least squares modeling data analysis revealed that nurse's perception of usefulness is the main factor in the adoption of mobile technology, having subjective norm and image within the organization as significant antecedents. Overall, this study was the first attempt at investigating scientifically, through a pertinent information systems research model, user adoption of mobile systems by homecare nursing personnel.

  18. Bridging the Gap between Social Acceptance and Ethical Acceptability.

    Science.gov (United States)

    Taebi, Behnam

    2017-10-01

    New technology brings great benefits, but it can also create new and significant risks. When evaluating those risks in policymaking, there is a tendency to focus on social acceptance. By solely focusing on social acceptance, we could, however, overlook important ethical aspects of technological risk, particularly when we evaluate technologies with transnational and intergenerational risks. I argue that good governance of risky technology requires analyzing both social acceptance and ethical acceptability. Conceptually, these two notions are mostly complementary. Social acceptance studies are not capable of sufficiently capturing all the morally relevant features of risky technologies; ethical analyses do not typically include stakeholders' opinions, and they therefore lack the relevant empirical input for a thorough ethical evaluation. Only when carried out in conjunction are these two types of analysis relevant to national and international governance of risky technology. I discuss the Rawlsian wide reflective equilibrium as a method for marrying social acceptance and ethical acceptability. Although the rationale of my argument is broadly applicable, I will examine the case of multinational nuclear waste repositories in particular. This example will show how ethical issues may be overlooked if we focus only on social acceptance, and will provide a test case for demonstrating how the wide reflective equilibrium can help to bridge the proverbial acceptance-acceptability gap. © 2016 The Authors Risk Analysis published by Wiley Periodicals, Inc. on behalf of Society for Risk Analysis.

  19. Model of Information and Communication Technology (ICT) Acceptance and Use for Teaching Staff in Sub-Saharan Africa Public Higher Education Institutions

    Science.gov (United States)

    Ouedraogo, Boukary

    2017-01-01

    This article uses data survey on 82 teachers from the University of Ouagadougou and the model of unified theory of acceptance and use of technology (UTAUT) to assess the determinants of acceptance and educational use of ICT by teachers. The paper's outcomes show that the construct "performance expectancy" of ICT (expected utility and…

  20. ANALISIS MINTA PENGGUNAAN LAYANAN E-FILING OLEH WAJIB PAJAK MELALUI PENDEKATAN TECHNOLOGY ACCEPTANCE MODEL (TAM DI KPP PRATAMA PURWAKARTA

    Directory of Open Access Journals (Sweden)

    Sri Widiyanesti

    2017-04-01

    Full Text Available Kepatuhan wajib pajak dalam melaporkan Surat Pemberitahuan (SPT merupakan syarat utama bagi penerimaan pajak yang optimal. Sejak tanggal 1 Februari 2012, Direktorat Jenderal Pajak (DJP telah menyediakan layanan yang dapat memudahkan wajib pajak dalam melaporkan SPT, yaitu melalui layanan e-Filing. Tingkat penerimaan user terhadap suatu teknologi baru merupakan hal yang perlu diperhatikan Teknologi yang memiliki kegunaan (perceived of usefulness dan kemudahan pengoperasian (perceived ease of use akan mempengaruhi sikap (attitude toward us user yang kemudian akan mempengaruhi minat (intention to use user dalam menggunakan teknologi tersebut. Penelitian ini bertujuan untuk mengetahui bagaimana perceived of uselness (PU dan perceived ease of use (PEOU dapat mempengaruhi attitude towards use (ATU yang kemudian akan mempengaruhi intention to use (ITUlayanan e-Filing oleh wajib pajak di KPP Pratama Purwakarta.