Calvert, S.C.; Snelder, M.; Taale, H.; Wageningen-Kessels, F.L.M. van; Hoogendoorn, S.P.
2015-01-01
In this contribution a model-based analysis of the application of bounded acceleration in traffic flow is considered as a cause for the capacity drop. This is performed in a Lagrangian formulation of the kinematic wave model with general vehicle specific characteristics. Unconstrained overtaking is
Petrosian, Vahé; Chen, Qingrong
2010-04-01
The model of stochastic acceleration of particles by turbulence has been successful in explaining many observed features of solar flares. Here, we demonstrate a new method to obtain the accelerated electron spectrum and important acceleration model parameters from the high-resolution hard X-ray (HXR) observations provided by RHESSI. In our model, electrons accelerated at or very near the loop top (LT) produce thin target bremsstrahlung emission there and then escape downward producing thick target emission at the loop footpoints (FPs). Based on the electron flux spectral images obtained by the regularized spectral inversion of the RHESSI count visibilities, we derive several important parameters for the acceleration model. We apply this procedure to the 2003 November 3 solar flare, which shows an LT source up to 100-150 keV in HXR with a relatively flat spectrum in addition to two FP sources. The results imply the presence of strong scattering and a high density of turbulence energy with a steep spectrum in the acceleration region.
Accelerated shallow water modeling
Gandham, Rajesh; Medina, David; Warburton, Timothy
2015-04-01
ln this talk we will describe our ongoing developments in accelerated numerical methods for modeling tsunamis, and oceanic fluid flows using two dimensional shallow water model and/or three dimensional incompressible Navier Stokes model discretized with high order discontinuous Galerkin methods. High order discontinuous Galerkin methods can be computationally demanding, requiring extensive computational time to simulate real time events on traditional CPU architectures. However, recent advances in computing architectures and hardware aware algorithms make it possible to reduce simulation time and provide accurate predictions in a timely manner. Hence we tailor these algorithms to take advantage of single instruction multiple data (SIMD) architecture that is seen in modern many core compute devices such as GPUs. We will discuss our unified and extensive many-core programming library OCCA that alleviates the need to completely re-design the solvers to keep up with constantly evolving parallel programming models and hardware architectures. We will present performance results for the flow simulations demonstrating performance leveraging multiple different multi-threading APIs on GPU and CPU targets.
Accelerated life models modeling and statistical analysis
Bagdonavicius, Vilijandas
2001-01-01
Failure Time DistributionsIntroductionParametric Classes of Failure Time DistributionsAccelerated Life ModelsIntroductionGeneralized Sedyakin's ModelAccelerated Failure Time ModelProportional Hazards ModelGeneralized Proportional Hazards ModelsGeneralized Additive and Additive-Multiplicative Hazards ModelsChanging Shape and Scale ModelsGeneralizationsModels Including Switch-Up and Cycling EffectsHeredity HypothesisSummaryAccelerated Degradation ModelsIntroductionDegradation ModelsModeling the Influence of Explanatory Varia
Hoogeveen, Lianne; van Hell, Janet G.; Verhoeven, Ludo
2012-01-01
Background: In the studies of acceleration conducted so far a multidimensional perspective has largely been neglected. No attempt has been made to relate social-emotional characteristics of accelerated versus non-accelerated students in perspective of environmental factors. Aims: In this study, social-emotional characteristics of accelerated…
Hoogeveen, A.J.M.; Hell, J.G. van; Verhoeven, L.T.W.
2012-01-01
Background. In the studies of acceleration conducted so far a multidimensional perspective has largely been neglected. No attempt has been made to relate social-emotional characteristics of accelerated versus non-accelerated students in perspective of environmental factors. Aims. In this study, soci
Mai Tong; Vladimir Rzhevsky; Dai Junwu; George C Lee; Qi Jincheng; Qi Xiaozhai
2007-01-01
Major earthquakes of last 15 years (e.g., Northridge 1994, Kobe 1995 and Chi-Chi 1999) have shown that many near-fault ground motions possess prominent acceleration pulses. Some of the prominent ground acceleration pulses are related to large ground velocity pulses, others are caused by mechanisms that are totally different from those causing the velocity pulses or fling steps. Various efforts to model acceleration pulses have been reported in the literature. In this paper, research results from a recent study of acceleration pulse prominent ground motions and an analysis of structural damage induced by acceleration pulses are summarized. The main results of the study include: (1) temporal characteristics of acceleration pulses; (2) ductility demand spectrum of simple acceleration pulses with respect to equivalent classes of dynamic systems and pulse characteristic parameters; and (3) estimation of fundamental period change under the excitation of strong acceleration pulses. By using the acceleration pulse induced linear acceleration spectrum and the ductility demand spectrum,a simple procedure has been developed to estimate the ductility demand and the fundamental period change of a reinforced concrete (RC) structure under the impact of a strong acceleration pulse.
Accelerated life testing effects on CMOS microcircuit characteristics
1980-01-01
The 250 C, 200C and 125C accelerated tests are described. The wear-out distributions from the 250 and 200 C tests were used to estimate the activation energy between the two test temperatures. The duration of the 125 C test was not sufficient to bring the test devices into the wear-out region. It was estimated that, for the most complex of the three devices types, the activation energy between 200 C and 125 C should be at least as high as that between 250 C and 200 C. The practicality of the use of high temperature for the accelerated life tests from the point of view of durability of equipment is assessed. Guidlines for the development of accelerated life-test conditions are proposed. The use of the silicon nitride overcoat to improve the high temperature accelerated life-test characteristics of CMOS microcircuits is described.
Self-accelerating Massive Gravity: Hidden Constraints and Characteristics
Motloch, Pavel; Motohashi, Hayato
2016-01-01
Self-accelerating backgrounds in massive gravity provide an arena to explore the Cauchy problem for derivatively coupled fields that obey complex constraints which reduce the phase space degrees of freedom. We present here an algorithm based on the Kronecker form of a matrix pencil that finds all hidden constraints, for example those associated with derivatives of the equations of motion, and characteristic curves for any 1+1 dimensional system of linear partial differential equations. With the Regge-Wheeler-Zerilli decomposition of metric perturbations into angular momentum and parity states, this technique applies to fully 3+1 dimensional perturbations of massive gravity around any isotropic self-accelerating background. Five spin modes of the massive graviton propagate once the constraints are imposed: two spin-2 modes with luminal characteristics present in the massless theory as well as two spin-1 modes and one spin-0 mode. Although the new modes all possess the same - typically spacelike - characteristi...
Opportunity of characteristic's improvement for accelerator driven systems
Kiselev, G V
2001-01-01
Review of sentences on the investigation into different variations of electronuclear plants be directed to the improvement in characteristics of the plants in an effort to the efficient disposal of long-lived components of radioactive wastes is presented. Attention is drown to the fact that subcritical reactor with complicated neutron valve can be used. This permits for drop in demand to current of proton accelerator. Briefly description of the process scheme with the indication of problems is given
Normalization of Gravitational Acceleration Models
Eckman, Randy A.; Brown, Aaron J.; Adamo, Daniel R.
2011-01-01
Unlike the uniform density spherical shell approximations of Newton, the con- sequence of spaceflight in the real universe is that gravitational fields are sensitive to the nonsphericity of their generating central bodies. The gravitational potential of a nonspherical central body is typically resolved using spherical harmonic approximations. However, attempting to directly calculate the spherical harmonic approximations results in at least two singularities which must be removed in order to generalize the method and solve for any possible orbit, including polar orbits. Three unique algorithms have been developed to eliminate these singularities by Samuel Pines [1], Bill Lear [2], and Robert Gottlieb [3]. This paper documents the methodical normalization of two1 of the three known formulations for singularity-free gravitational acceleration (namely, the Lear [2] and Gottlieb [3] algorithms) and formulates a general method for defining normalization parameters used to generate normalized Legendre Polynomials and ALFs for any algorithm. A treatment of the conventional formulation of the gravitational potential and acceleration is also provided, in addition to a brief overview of the philosophical differences between the three known singularity-free algorithms.
Production of accelerating quad Airy beams and their optical characteristics.
Ren, Zhijun; Wu, Qiong; Shi, Yile; Chen, Chen; Wu, Jiangmiao; Wang, Hui
2014-06-16
Based on a geometric caustic argument and diffraction catastrophe theory, we generate a novel form of accelerating beams using a symmetric 3/2 phase-only pattern. Such beams can be called accelerating quad Airy beams (AQABs) because they look very much like four face-to-face combined Airy beams. Optical characteristics of AQABs are subsequently investigated. The research results show that the beams have axial-symmetrical and centrosymmetrical transverse intensity patterns and quasi-diffraction-free propagation features for their four main lobes while undergoing transverse shift along parabolic trajectories. Moreover, we also demonstrate that AQABs possess self-construction ability when local areas are blocked. The unique optical properties of these beams will make them useful tools for future scientific applications.
Self-accelerating massive gravity: Hidden constraints and characteristics
Motloch, Pavel; Hu, Wayne; Motohashi, Hayato
2016-05-01
Self-accelerating backgrounds in massive gravity provide an arena to explore the Cauchy problem for derivatively coupled fields that obey complex constraints which reduce the phase space degrees of freedom. We present here an algorithm based on the Kronecker form of a matrix pencil that finds all hidden constraints, for example those associated with derivatives of the equations of motion, and characteristic curves for any 1 +1 dimensional system of linear partial differential equations. With the Regge-Wheeler-Zerilli decomposition of metric perturbations into angular momentum and parity states, this technique applies to fully 3 +1 dimensional perturbations of massive gravity around any spherically symmetric self-accelerating background. Five spin modes of the massive graviton propagate once the constraints are imposed: two spin-2 modes with luminal characteristics present in the massless theory as well as two spin-1 modes and one spin-0 mode. Although the new modes all possess the same—typically spacelike—characteristic curves, the spin-1 modes are parabolic while the spin-0 modes are hyperbolic. The joint system, which remains coupled by nonderivative terms, cannot be solved as a simple Cauchy problem from a single noncharacteristic surface. We also illustrate the generality of the algorithm with other cases where derivative constraints reduce the number of propagating degrees of freedom or order of the equations.
Ram accelerator operating characteristics at elevated fill pressures
Bundy, C.; Knowlen, C.; Bruckner, A.P. [Washington Univ., Seattle, WA (United States). Aerospace and Energetics Research Program
2000-11-01
An experimental investigation of the starting and operational characteristics of a 38-mm bore ram accelerator with propellant fill pressures greater than 5 MPa is in progress. Successful starts with 60 - 124 gm projectiles have been achieved using methane/oxygen/nitrogen propellants at fill pressures ranging from 6 to 15 MPa. At fill pressures of 8.5 MPa and above, it was found that projectiles having the nominal throat diameter (29 mm) required a minimum entrance velocity of 1250 m/s, which is about 100 m/s faster than the minimum needed to successfully start the ram accelerator at fill pressures below 7.5 MPa. Projectiles with a reduced throat diameter (25 mm) and a solid magnesium nose cone were successfully started at fill pressures up to 15 MPa with entrance velocities around 1300 m/s. The average accelerations achieved using high pressure stages were in general less than predicted for thermally choked operation by the Boltzmann equation of state. (orig.)
Flexible boosting of accelerated failure time models
Hothorn Torsten
2008-06-01
Full Text Available Abstract Background When boosting algorithms are used for building survival models from high-dimensional data, it is common to fit a Cox proportional hazards model or to use least squares techniques for fitting semiparametric accelerated failure time models. There are cases, however, where fitting a fully parametric accelerated failure time model is a good alternative to these methods, especially when the proportional hazards assumption is not justified. Boosting algorithms for the estimation of parametric accelerated failure time models have not been developed so far, since these models require the estimation of a model-specific scale parameter which traditional boosting algorithms are not able to deal with. Results We introduce a new boosting algorithm for censored time-to-event data which is suitable for fitting parametric accelerated failure time models. Estimation of the predictor function is carried out simultaneously with the estimation of the scale parameter, so that the negative log likelihood of the survival distribution can be used as a loss function for the boosting algorithm. The estimation of the scale parameter does not affect the favorable properties of boosting with respect to variable selection. Conclusion The analysis of a high-dimensional set of microarray data demonstrates that the new algorithm is able to outperform boosting with the Cox partial likelihood when the proportional hazards assumption is questionable. In low-dimensional settings, i.e., when classical likelihood estimation of a parametric accelerated failure time model is possible, simulations show that the new boosting algorithm closely approximates the estimates obtained from the maximum likelihood method.
Transient accelerating scalar models with exponential potentials
Wen-Ping Cui; Yang Zhang; Zheng-Wen Fu
2013-01-01
We study a known class of scalar dark energy models in which the potential has an exponential term and the current accelerating era is transient.We find that,although a decelerating era will return in the future,when extrapolating the model back to earlier stages (z(≥) 4),scalar dark energy becomes dominant over matter.So these models do not have the desired tracking behavior,and the predicted transient period of acceleration cannot be adopted into the standard scenario of the Big Bang cosmology.When couplings between the scalar field and matter are introduced,the models still have the same problem; only the time when deceleration returns will be varied.To achieve re-deceleration,one has to turn to alternative models that are consistent with the standard Big Bang scenario.
A Qualitative Acceleration Model Based on Intervals
Ester MARTINEZ-MARTIN
2013-08-01
Full Text Available On the way to autonomous service robots, spatial reasoning plays a main role since it properly deals with problems involving uncertainty. In particular, we are interested in knowing people's pose to avoid collisions. With that aim, in this paper, we present a qualitative acceleration model for robotic applications including representation, reasoning and a practical application.
Jia, Mei-Hui; Wang, Cheng-Lin; Ren, Bin
2017-07-01
Stress, strain and vibration characteristics of rotor parts should be changed significantly under high acceleration, manufacturing error is one of the most important reason. However, current research on this problem has not been carried out. A rotor with an acceleration of 150,000 g is considered as the objective, the effects of manufacturing errors on rotor mechanical properties and dynamic characteristics are executed by the selection of the key affecting factors. Through the force balance equation of the rotor infinitesimal unit establishment, a theoretical model of stress calculation based on slice method is proposed and established, a formula for the rotor stress at any point derives. A finite element model (FEM) of rotor with holes is established with manufacturing errors. The changes of the stresses and strains of a rotor in parallelism and symmetry errors are analyzed, which verify the validity of the theoretical model. The pre-stressing modal analysis is performed based on the aforementioned static analysis. The key dynamic characteristics are analyzed. The results demonstrated that, as the parallelism and symmetry errors increase, the equivalent stresses and strains of the rotor slowly increase linearly, the highest growth rate does not exceed 4%, the maximum change rate of natural frequency is 0.1%. The rotor vibration mode is not significantly affected. The FEM construction method of the rotor with manufacturing errors can be utilized for the quantitative research on rotor characteristics, which will assist in the active control of rotor component reliability under high acceleration.
Computational modeling of high pressure combustion mechanism in scram accelerator
Choi, J.Y. [Pusan Nat. Univ. (Korea); Lee, B.J. [Pusan Nat. Univ. (Korea); Agency for Defense Development, Taejon (Korea); Jeung, I.S. [Pusan Nat. Univ. (Korea); Seoul National Univ. (Korea). Dept. of Aerospace Engineering
2000-11-01
A computational study was carried out to analyze a high-pressure combustion in scram accelerator. Fluid dynamic modeling was based on RANS equations for reactive flows, which were solved in a fully coupled manner using a fully implicit-upwind TVD scheme. For the accurate simulation of high-pressure combustion in ram accelerator, 9-species, 25-step fully detailed reaction mechanism was incorporated with the existing CFD code previously used for the ram accelerator studies. The mechanism is based on GRI-Mech. 2.11 that includes pressure-dependent reaction rate formulations indispensable for the correct prediction of induction time in high-pressure environment. A real gas equation of state was also included to account for molecular interactions and real gas effects of high-pressure gases. The present combustion modeling is compared with previous 8-step and 19-step mechanisms with ideal gas assumption. The result shows that mixture ignition characteristics are very sensitive to the combustion mechanisms, and different mechanism results in different reactive flow-field characteristics that have a significant relevance to the operation mode and the performance of scram accelerator. (orig.)
CMFD and GPU acceleration on method of characteristics for hexagonal cores
Han, Yu, E-mail: hanyu1203@gmail.com [School of Nuclear Science and Engineering, Shanghai Jiaotong University, Shanghai 200240 (China); Jiang, Xiaofeng [Shanghai NuStar Nuclear Power Technology Co., Ltd., No. 81 South Qinzhou Road, XuJiaHui District, Shanghai 200000 (China); Wang, Dezhong [School of Nuclear Science and Engineering, Shanghai Jiaotong University, Shanghai 200240 (China)
2014-12-15
Highlights: • A merged hex-mesh CMFD method solved via tri-diagonal matrix inversion. • Alternative hardware acceleration of using inexpensive GPU. • A hex-core benchmark with solution to confirm two acceleration methods. - Abstract: Coarse Mesh Finite Difference (CMFD) has been widely adopted as an effective way to accelerate the source iteration of transport calculation. However in a core with hexagonal assemblies there are non-hexagonal meshes around the edges of assemblies, causing a problem for CMFD if the CMFD equations are still to be solved via tri-diagonal matrix inversion by simply scanning the whole core meshes in different directions. To solve this problem, we propose an unequal mesh CMFD formulation that combines the non-hexagonal cells on the boundary of neighboring assemblies into non-regular hexagonal cells. We also investigated the alternative hardware acceleration of using graphics processing units (GPU) with graphics card in a personal computer. The tool CUDA is employed, which is a parallel computing platform and programming model invented by the company NVIDIA for harnessing the power of GPU. To investigate and implement these two acceleration methods, a 2-D hexagonal core transport code using the method of characteristics (MOC) is developed. A hexagonal mini-core benchmark problem is established to confirm the accuracy of the MOC code and to assess the effectiveness of CMFD and GPU parallel acceleration. For this benchmark problem, the CMFD acceleration increases the speed 16 times while the GPU acceleration speeds it up 25 times. When used simultaneously, they provide a speed gain of 292 times.
Mathematical model of two-phase flow in accelerator channel
О.Ф. Нікулін
2010-01-01
Full Text Available The problem of two-phase flow composed of energy-carrier phase (Newtonian liquid and solid fine-dispersed phase (particles in counter jet mill accelerator channel is considered. The mathematical model bases goes on the supposition that the phases interact with each other like independent substances by means of aerodynamics’ forces in conditions of adiabatic flow. The mathematical model in the form of system of differential equations of order 11 is represented. Derivations of equations by base physical principles for cross-section-averaged quantity are produced. The mathematical model can be used for estimation of any kinematic and thermodynamic flow characteristics for purposely parameters optimization problem solving and transfer functions determination, that take place in counter jet mill accelerator channel design.
Operational Characteristics of an Accelerator Driven Fissile Solution System
Kimpland, Robert Herbert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2016-11-28
Operational characteristics represent the set of responses that a nuclear system exhibits during normal operation. Operators rely on this behavior to assess the status of the system and to predict the consequences of off-normal events. These characteristics largely refer to the relationship between power and system operating conditions. The static and dynamic behavior of a chain-reacting system, operating at sufficient power, is primarily governed by reactivity effects. The science of reactor physics has identified and evaluated a number of such effects, including Doppler broadening and shifts in the thermal neutron spectrum. Often these reactivity effects are quantified in the form of feedback coefficients that serve as coupling coefficients relating the neutron population and the physical mechanisms that drive reactivity effects, such as fissile material temperature and density changes. The operational characteristics of such nuclear systems usually manifest themselves when perturbations between system power (neutron population) and system operating conditions arise. Successful operation of such systems require the establishment of steady equilibrium conditions. However, prior to obtaining the desired equilibrium (steady-state) conditions, an approach from zero-power (startup) must occur. This operational regime may possess certain limiting system conditions that must be maintained to achieve effective startup. Once steady-state is achieved, a key characteristic of this operational regime is the level of stability that the system possesses. Finally, a third operational regime, shutdown, may also possess limiting conditions of operation that must be maintained. This report documents the operational characteristics of a “generic” Accelerator Driven Fissile Solution (ADFS) system during the various operational regimes of startup, steady-state operation, and shutdown. Typical time-dependent behavior for each operational regime will be illustrated, and key system
Jet browser model accelerated by GPUs
Forster Richárd
2016-12-01
Full Text Available In the last centuries the experimental particle physics began to develop thank to growing capacity of computers among others. It is allowed to know the structure of the matter to level of quark gluon. Plasma in the strong interaction. Experimental evidences supported the theory to measure the predicted results. Since its inception the researchers are interested in the track reconstruction. We studied the jet browser model, which was developed for 4π calorimeter. This method works on the measurement data set, which contain the components of interaction points in the detector space and it allows to examine the trajectory reconstruction of the final state particles. We keep the total energy in constant values and it satisfies the Gauss law. Using GPUs the evaluation of the model can be drastically accelerated, as we were able to achieve up to 223 fold speedup compared to a CPU based parallel implementation.
Characteristics of induced activity from medical linear accelerators.
Wang, Yi Zhen; Evans, Michael D C; Podgorsak, Ervin B
2005-09-01
A study of the induced activity in a medical linear accelerator (linac) room was carried out on several linac installations. Higher beam energy, higher dose rate, and larger field size generally result in higher activation levels at a given point of interest, while the use of multileaf collimators (MLC) can also increase the activation level at the isocenter. Both theoretical and experimental studies reveal that the activation level in the morning before any clinical work increases from Monday to Saturday and then decreases during the weekend. This weekly activation picture keeps stable from one week to another during standard clinical operation of the linac. An effective half-life for a given point in the treatment room can be determined from the measured or calculated activity decay curves. The effective half-life for points inside the treatment field is longer than that for points outside of the field in the patient plane, while a larger field and longer irradiation time can also make the effective half-life longer. The activation level reaches its practical saturation value after a 30 min continuous irradiation, corresponding to 12 000 MU at a "dose rate" of 400 MU/min. A "dose" of 300 MU was given 20 times in 15 min intervals to determine the trends in the activation level in a typical clinical mode. As well, a long-term (85 h over a long weekend) decay curve was measured to evaluate the long-term decay of room activation after a typical day of clinical linac use. A mathematical model for the activation level at the isocenter has been established and shown to be useful in explaining and predicting the induced activity levels for typical clinical and experimental conditions. The activation level for a 22 MeV electron beam was also measured and the result shows it is essentially negligible.
A model of an accelerating Universe
Arbab, A I
1999-01-01
We have considered a cosmological model with a cosmological term proportional to the deceleration parameter. For age parameter consistent with observational data the Universe must be accelerating in the presence of a positive cosmological term. The minimum age of the Universe is $H_0^{-1}$, where $H_0$ is the present Hubble constant. The cosmological term decreases as $t^{-2}$. The rate of particle creation is very small compared with the Steady State prediction. Allowing the gravitational constant to change with time leads to an ever increasing gravitational constant at the present epoch. In the presence of a viscous fluid this decay law for $\\Lambda$ is equivalent to the one with the de-Sitter type.
Transforming a School of Education via the Accelerated Schools Model.
Mims, J. Sabrina; Slovacek, Simeon; Wong, Gay Yuen
This paper describes how the Accelerated Schools Model has served as a catalyst for transforming the Charter School of Education at California State University, Los Angeles. The Accelerated Schools Project has been one of the largest and most comprehensive school restructuring movements of the last decade. The focus of Accelerated Schools is…
A Simplified Model for the Acceleration of Cosmic Ray Particles
Gron, Oyvind
2010-01-01
Two important questions concerning cosmic rays are: Why are electrons in the cosmic rays less efficiently accelerated than nuclei? How are particles accelerated to great energies in ultra-high energy cosmic rays? In order to answer these questions we construct a simple model of the acceleration of a charged particle in the cosmic ray. It is not…
Beam-commissioning study of high-intensity accelerators using virtual accelerator model
Harada, H.; Shigaki, K.; Irie, Y.; Noda, F.; Hotchi, H.; Saha, P. K.; Shobuda, Y.; Sako, H.; Furukawa, K.; Machida, S.
2009-04-01
In order to control large-scale accelerators efficiently, a control system with a virtual accelerator model was constructed. The virtual accelerator (VA) is an on-line beam simulator provided with a beam monitor scheme. The VA is based upon the Experimental Physics and Industrial Control System (EPICS) and is configured under the EPICS input/output controller (IOC) in parallel with a real accelerator (RA). Thus, the machine operator can access the parameters of the RA through the channel access client and then feed them to the VA, and vice versa. Such a control scheme facilitates developments of the commissioning tools, feasibility study of the proposed accelerator parameters and examination of the measured accelerator data. This paper describes the beam commissioning results and activities by using the VA at the J-PARC 3-GeV rapid-cycling synchrotron (RCS).
Beam-commissioning study of high-intensity accelerators using virtual accelerator model
Harada, H. [Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima-shi, Hiroshima 739-8526 (Japan)], E-mail: harada@hepl.hiroshima-u.ac.jp; Shigaki, K. [Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima-shi, Hiroshima 739-8526 (Japan); Irie, Y. [Accelerator Laboratory, High Energy Accelerator Research Organization (KEK), Tsukuba-shi, Ibaraki 305-0801 (Japan); Noda, F. [Energy and Environmental Systems Laboratory, Hitachi, Ltd, 7-2-1 Omika-cho, Hitachi-shi, Ibaraki 319-1221 (Japan); Hotchi, H.; Saha, P.K.; Shobuda, Y.; Sako, H. [Japan Proton Accelerator Research Complex, 2-4 Shirane Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1195 (Japan); Furukawa, K. [Accelerator Laboratory, High Energy Accelerator Research Organization (KEK), Tsukuba-shi, Ibaraki 305-0801 (Japan); Machida, S. [Science and Technology Facilities Council, Rutherford Appleton Laboratory, Chilton, Didcot, Oxon OX11, 0QX (United Kingdom)
2009-04-21
In order to control large-scale accelerators efficiently, a control system with a virtual accelerator model was constructed. The virtual accelerator (VA) is an on-line beam simulator provided with a beam monitor scheme. The VA is based upon the Experimental Physics and Industrial Control System (EPICS) and is configured under the EPICS input/output controller (IOC) in parallel with a real accelerator (RA). Thus, the machine operator can access the parameters of the RA through the channel access client and then feed them to the VA, and vice versa. Such a control scheme facilitates developments of the commissioning tools, feasibility study of the proposed accelerator parameters and examination of the measured accelerator data. This paper describes the beam commissioning results and activities by using the VA at the J-PARC 3-GeV rapid-cycling synchrotron (RCS)
Suslov, I.R. [Institute for Physics and Power Engineering, Obninsk (Russian Federation)
2003-07-01
An acceleration technique for long characteristics discrete ordinates method is presented. The technique is based on the developed representation of the transport sweep finite-difference operator as an sparse matrix operator in the space of the track averaged symmetrized angular fluxes. The collapsing technique is used for the constructing of the reduced sparse matrix with structure similar to block-diffusion in general case. That reduced matrix is applied for the acceleration of the scattering iterations. For slab geometry case it is shown that the simplest (one box collapsing) method is equivalent to consistent diffusion acceleration method. Numerical results for the two-dimensional C5G7MOX OECD benchmark display high efficiency of the developed method. (author)
Busurin, V. I.; Korobkov, V. V.; Htoo Lwin, Naing; Tuan, Phan Anh
2016-08-01
Theoretical and experimental analysis of quasi-linear conversion function of angular velocity and acceleration microoptoelectromechnical (MOEM) transducers based on optical tunneling effect (OTE) are conducted. Equivalent oscillating circuit is developed and dynamic characteristics of angular velocity and acceleration MOEM-transducers are investigated.
Accelerated life testing effects on CMOS microcircuit characteristics, phase 1
Maximow, B.
1976-01-01
An accelerated life test of sufficient duration to generate a minimum of 50% cumulative failures in lots of CMOS devices was conducted to provide a basis for determining the consistency of activation energy at 250 C. An investigation was made to determine whether any thresholds were exceeded during the high temperature testing, which could trigger failure mechanisms unique to that temperature. The usefulness of the 250 C temperature test as a predictor of long term reliability was evaluated.
Accelerated life testing and temperature dependence of device characteristics in GaAs CHFET devices
Gallegos, M.; Leon, R.; Vu, D. T.; Okuno, J.; Johnson, A. S.
2002-01-01
Accelerated life testing of GaAs complementary heterojunction field effect transistors (CHFET) was carried out. Temperature dependence of single and synchronous rectifier CHFET device characteristics were also obtained.
White Paper on DOE-HEP Accelerator Modeling Science Activities
Vay, Jean-Luc; Koniges, Alice; Friedman, Alex; Grote, David P; Bruhwiler, David L
2013-01-01
Toward the goal of maximizing the impact of computer modeling on the design of future particle accelerators and the development of new accelerator techniques & technologies, this white paper presents the rationale for: (a) strengthening and expanding programmatic activities in accelerator modeling science within the Department of Energy (DOE) Office of High Energy Physics (HEP) and (b) increasing the community-wide coordination and integration of code development.
Accelerated propor tional degradation hazards-odds model in accelerated degradation test
Tingting Huang; Zhizhong Li
2015-01-01
An accelerated proportional degradation hazards-odds model is proposed. It is a non-parametric model and thus has path-free and distribution-free properties, avoiding the errors caused by faulty assumptions of degradation paths or distribution of degra-dation measurements. It is established based on a link function which combines the degradation cumulative hazard rate function and the degradation odds function through a transformation pa-rameter, and this makes the accelerated proportional degradation hazards model and the accelerated proportional degradation odds model special cases of it. Hypothesis tests are discussed, and the proposed model is applicable when some model assumptions are satisfied. This model is utilized to estimate the reliability of minia-ture bulbs under low stress levels based on the degradation data obtained under high stress levels to validate the effectiveness of this model.
Universe acceleration in brane world models
Chiou-Lahanas, C.; Diamandis, G. A.; Georgalas, B. C.
2014-05-01
We examine the cosmology induced on a brane moving in the background of a five-dimensional black hole, solution of the string effective action. The evolution, determined by the Israel junction conditions is found to be compatible with an accelerating universe with the present day acceleration coming after a decelerating phase. The possible species of the energy-momentum tensor, localized on the brane, for these solutions to be valid are discussed.
Universe Acceleration in Brane World Models
Chiou-Lahanas, C; Georgalas, B C
2013-01-01
We examine the cosmology induced on a brane moving in the background of a five-dimensional black hole, solution of the string effective action. The evolution determined by the Israel junction conditions is found to be compatible with an accelerating universe with the present day acceleration coming after a decelerating phase. The conditions imposed on the energy-momentum tensor, localized on the brane, for these solutions to be valid are discussed.
The charged particle accelerators subsystems modeling
Averyanov, G. P.; Kobylyatskiy, A. V.
2017-01-01
Presented web-based resource for information support the engineering, science and education in Electrophysics, containing web-based tools for simulation subsystems charged particle accelerators. Formulated the development motivation of Web-Environment for Virtual Electrophysical Laboratories. Analyzes the trends of designs the dynamic web-environments for supporting of scientific research and E-learning, within the framework of Open Education concept.
Symmetry breaking and cosmic acceleration in scalar field models
Sadjadi, M Mohseni; Sepangi, H R
2015-01-01
We study the possible role of symmetry breaking in the onset of the acceleration of the Universe in a scalar field dark energy model. We propose a new scenario in which acceleration of the Universe is driven by a positive potential produced by means of symmetry breaking.
Vatnitskiĭ, S M; Ermakov, I A; Puzanov, V P; Sinitsyn, R V; Cherviakov, A M
1983-10-01
The paper presents methods and results of a study of radiation-physical characteristics of inhibitory radiation beam with the Grenz energy of 15MeV generated by an electron linear accelerator LUE-15M. Special emphasis is laid on primary dosimetric information used for the planning of radiotherapy: depth doses, beam profiles, dose functions of a collimated beam. It has been shown that in general the accelerator meets the requirements of the International Electrotechnical Commission. General error in the focal absorbed dose at the expense of variable parameters of the accelerator was evaluated. It does not exceed +/- 3.5%.
Community College Model Characteristics.
Raby, Rosalind Latiner
This paper argues that community college models, especially in developing countries, can be victims of the vocational school fallacy, which holds that that two-year vocational/technical schools that ignore a general education foundation may not be an optimal means for solving worker needs. In addition, globalization has hastened a mirroring of the…
Time-Dependent Stochastic Acceleration Model for the Fermi Bubbles
Sasaki, Kento; Terasawa, Toshio
2015-01-01
We study stochastic acceleration models for the Fermi bubbles. Turbulence is excited just behind the shock front via Kelvin-Helmholtz, Rayleigh-Taylor or Richtmyer-Meshkov instabilities, and plasma particles are continuously accelerated by the interaction with the turbulence. The turbulence gradually decays as it goes away from the shock fronts. Adopting a phenomenological model for the stochastic acceleration, we explicitly solve the temporal evolution of the particle energy distribution in the turbulence. Our results show that the spatial distribution of high-energy particles is different from those for a steady solution. We also show that the contribution of electrons escaped from the acceleration regions significantly softens the photon spectrum. The photon spectrum and surface brightness profile are reproduced by our models. If the escape efficiency is very high, the radio flux from the escaped low-energy electrons can be comparable to that of the WMAP haze. We also demonstrate hadronic models with the s...
Dynamic Characteristics and Models
Pedersen, Lars
2007-01-01
Vibration levels of flooring-systems are generally difficult to predict. Nevertheless an estimate may be needed for flooring-systems that are prone to vibrate to actions of humans in motion (e.g. grandstands, footbridges or long-span office floors). One reason for the difficulties...... and the paper therefore looks into this mechanism which is done by carrying out controlled modal identification tests on a test floor. The paper describes the experimental investigations and the basic principles adopted for modal identification. Since there is an interest in being able to model the scenario...
Accelerate Climate Models with the IBM Cell Processor
Zhou, S.; Duffy, D.; Clune, T.; Williams, S.; Suarez, M.; Halem, M.
2008-12-01
Ever increasing model resolutions and physical processes in climate models demand continual computing power increases. The IBM Cell processor's order-of- magnitude peak performance increase over conventional processors makes it very attractive for fulfilling this requirement. However, the Cell's characteristics: 256KB local memory per SPE and the new low-level communication mechanism, make it very challenging to port an application. We selected the solar radiation component of the NASA GEOS-5 climate model, which: (1) is representative of column physics components (~50% total computation time), (2) has a high computational load relative to data traffic to/from main memory, and (3) performs independent calculations across multiple columns. We converted the baseline code (single-precision, Fortran code) to C and ported it to an IBM BladeCenter QS20, manually SIMDizing 4 independent columns, and found that a Cell with 8 SPEs can process more than 3000 columns per second. Compared with the baseline results, the Cell is ~6.76x, ~8.91x, ~9.85x faster than a core on Intel's Xeon Woodcrest, Dempsey, and Itanium2 respectively. Our analysis shows that the Cell could also speed up the dynamics component (~25% total computation time). We believe this dramatic performance improvement makes the Cell processor very competitive, at least as an accelerator. We will report our experience in porting both the C and Fortran codes and will discuss our work in porting other climate model components.
Viscous cosmological models and accelerated Universes
Kremer, G M
2003-01-01
It is shown that a present acceleration with a past deceleration is a possible solution of the Friedmann equation by considering the Universe as a mixture of a scalar with a matter field and by including a non-equilibrium pressure term in the energy-momentum tensor. The dark energy density decays more slowly with respect to the time than the matter energy density does. The inclusion of the non-equilibrium pressure leads to a less pronounced decay of the matter field with a shorter period of past deceleration.
Theoretical and experimental modeling of a rail gun accelerator
Zheleznyj, V. B.; Zagorskij, A. V.; Katsnel'Son, S. S.; Kudryavtsev, A. V.; Plekhanov, A. V.
1993-04-01
Results of a series of experiments in the acceleration of macrobodies are analyzed using an integral model of a current arc and a quasi-1D magnetic gasdynamic model. The integral model uses gasdynamic equations averaged by the size of a plasma pump and equations based on the second Kirchhoff's law for electrical current. The quasi-1D model is based on 1D magnetic gasdynamic equations for mean values of density, pressure, velocity, and internal power. Electromagnetic parameters are determined from Maxwell integral equations. It is concluded that the proposed models take into account the major mechanisms of momentum loss and are capable of adequately describing electromagnetic rail accelerators.
Computer modeling of test particle acceleration at oblique shocks
Decker, Robert B.
1988-01-01
The present evaluation of the basic techniques and illustrative results of charged particle-modeling numerical codes suitable for particle acceleration at oblique, fast-mode collisionless shocks emphasizes the treatment of ions as test particles, calculating particle dynamics through numerical integration along exact phase-space orbits. Attention is given to the acceleration of particles at planar, infinitessimally thin shocks, as well as to plasma simulations in which low-energy ions are injected and accelerated at quasi-perpendicular shocks with internal structure.
Friedman-Robertson-Walker Models with Late-Time Acceleration
Abdussattar; S. R. Prajapati2
2011-01-01
@@ In order to account for the observed cosmic acceleration, a modiGcation of the ansatz for the variation of density in Friedman-Robertson-Walker (FRW) FRW models given by Islam is proposed.The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that of a modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.%In order to account for the observed cosmic acceleration, a modification of the ansatz for the variation of density in Friedman-Robertson-Walker (FRW) FRW models given by Islam is proposed. The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that ora modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.
Mero, Antti
1988-01-01
Investigation of the force-time characteristics of eight male sprinters during the acceleration phase of the sprint start suggested that the braking and propulsion phases occur immediately after the block phase and that muscle strength strongly affects running velocity in the sprint start. (Author/CB)
You, Bong; Lee, Jae Han; Ku, Kyung Hoi [Korea Atomic Energy Research Institute, Daeduk (Korea, Republic of)
1996-05-01
The evaluation of acceleration responses of isolated and nonisolated structures according to mechanical features of soils is important. The kinds of soils taken in analyses are soft, medium and hard rocks, and a fixed base condition is also taken for the comparison. The horizontal isolation frequency used is 0.5 Hz. The time history analyses of reference power plant using 1940 El Centro horizontal (NS) and vertical earthquakes are performed to investigate the seismic responses varying with soil characteristics for isolated and nonisolated structures. The horizontal acceleration responses of the horizontal isolated-structures show almost similar values irrespective of the various kinds of soils and are largely decreased in the frequency ranges above 2 hz. The vertical natural frequency, 21Hz of high damping rubber bearing does not affect the vertical acceleration responses in case of soft rock, but largely affects in hard rock condition. For nonisolated structures, the acceleration responses are decreased in both horizontal and vertical directions by taking into account the soils in the analysis model. The extent of reduction of acceleration responses is larger in vertical direction than in horizontal one, as the stiffness of rock becomes softer. 8 tabs., 21 figs., 8 refs. (Author) .new.
Vibration acceleration promotes bone formation in rodent models
Uchida, Ryohei; Nakata, Ken; Kawano, Fuminori; Yonetani, Yasukazu; Ogasawara, Issei; Nakai, Naoya; Mae, Tatsuo; Matsuo, Tomohiko; Tachibana, Yuta; Yokoi, Hiroyuki; Yoshikawa, Hideki
2017-01-01
All living tissues and cells on Earth are subject to gravitational acceleration, but no reports have verified whether acceleration mode influences bone formation and healing. Therefore, this study was to compare the effects of two acceleration modes, vibration and constant (centrifugal) accelerations, on bone formation and healing in the trunk using BMP 2-induced ectopic bone formation (EBF) mouse model and a rib fracture healing (RFH) rat model. Additionally, we tried to verify the difference in mechanism of effect on bone formation by accelerations between these two models. Three groups (low- and high-magnitude vibration and control-VA groups) were evaluated in the vibration acceleration study, and two groups (centrifuge acceleration and control-CA groups) were used in the constant acceleration study. In each model, the intervention was applied for ten minutes per day from three days after surgery for eleven days (EBF model) or nine days (RFH model). All animals were sacrificed the day after the intervention ended. In the EBF model, ectopic bone was evaluated by macroscopic and histological observations, wet weight, radiography and microfocus computed tomography (micro-CT). In the RFH model, whole fracture-repaired ribs were excised with removal of soft tissue, and evaluated radiologically and histologically. Ectopic bones in the low-magnitude group (EBF model) had significantly greater wet weight and were significantly larger (macroscopically and radiographically) than those in the other two groups, whereas the size and wet weight of ectopic bones in the centrifuge acceleration group showed no significant difference compared those in control-CA group. All ectopic bones showed calcified trabeculae and maturated bone marrow. Micro-CT showed that bone volume (BV) in the low-magnitude group of EBF model was significantly higher than those in the other two groups (3.1±1.2mm3 v.s. 1.8±1.2mm3 in high-magnitude group and 1.3±0.9mm3 in control-VA group), but BV in the
Friedman—Robertson—Walker Models with Late-Time Acceleration
Abdussattar; Prajapati, S. R.
2011-02-01
In order to account for the observed cosmic acceleration, a modification of the ansatz for the variation of density in Friedman—Robertson—Walker (FRW) FRW models given by Islam is proposed. The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that of a modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.
Friedmann-Robertson-Walker Models with Late-Time Acceleration
Abdussattar,
2016-01-01
In order to account for the observed cosmic acceleration, a modification of the ansatz for the variation of density in Friedman-Robertson-Walker (FRW) models given by Islam is proposed. The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that of a modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.
Research on cubic polynomial acceleration and deceleration control model for high speed NC machining
Hong-bin LENG; Yi-jie WU; Xiao-hong PAN
2008-01-01
To satisfy the need of high speed NC (numerical control) machining, an acceleration and deceleration (aec/dec) control model is proposed, and the speed curve is also constructed by the cubic polynomial. The proposed control model provides continuity of acceleration, which avoids the intense vibration in high speed NC machining. Based on the discrete characteristic of the data sampling interpolation, the acc/dec control discrete mathematical model is also set up and the discrete expression of the theoretical deceleration length is obtained furthermore. Aiming at the question of hardly predetermining the deceleration point in acc/dec control before interpolation, the adaptive acc/dec control algorithm is deduced from the expressions of the theoretical deceleration length. The experimental result proves that the acc/dec control model has the characteristic of easy implementation, stable movement and low impact. The model has been applied in multi-axes high speed micro fabrication machining successfully.
A Phenomenological Cost Model for High Energy Particle Accelerators
Shiltsev, Vladimir
2014-01-01
Accelerator-based high-energy physics have been in the forefront of scientific discoveries for more than half a century. The accelerator technology of the colliders has progressed immensely, while the beam energy, luminosity, facility size, and cost have grown by several orders of magnitude. The method of colliding beams has not fully exhausted its potential but has slowed down considerably in its progress. In this paper we derive a simple scaling model for the cost of large accelerators and colliding beam facilities based on costs of 17 big facilities which have been either built or carefully estimated. Although this approach cannot replace an actual cost estimate based on an engineering design, this parameterization is to indicate a somewhat realistic cost range for consideration of what future frontier accelerator facilities might be fiscally realizable.
Hallock, Ashley K.; Polzin, Kurt A.; Kimberlin, Adam C.
2012-01-01
Operational characteristics of two separate inductive thrusters with coils of different cone angles are explored through thrust stand measurements and time-integrated, un- filtered photography. Trends in impulse bit measurements indicate that, in the present experimental configuration, the thruster with the inductive coil possessing a smaller cone angle produced larger values of thrust, in apparent contradiction to results of a previous thruster acceleration model. Areas of greater light intensity in photographs of thruster operation are assumed to qualitatively represent locations of increased current density. Light intensity is generally greater in images of the thruster with the smaller cone angle when compared to those of the thruster with the larger half cone angle for the same operating conditions. The intensity generally decreases in both thrusters for decreasing mass ow rate and capacitor voltage. The location of brightest light intensity shifts upstream for decreasing mass ow rate of propellant and downstream for decreasing applied voltage. Recognizing that there typically exists an optimum ratio of applied electric field to gas pressure with respect to breakdown efficiency, this result may indicate that the optimum ratio was not achieved uniformly over the coil face, leading to non-uniform and incomplete current sheet formation in violation of the model assumption of immediate formation where all the injected propellant is contained in a magnetically-impermeable current sheet.
Modelling the non-gravitational acceleration during Cassini's gravitation experiments
Bertolami, O; Gil, P J S; Páramos, J
2014-01-01
In this work we present a computation of the thermally generated acceleration on the Cassini probe during its solar conjunction experiment, obtained from a model of the spacecraft. We use a point-like source method to build a thermal model of the vehicle and find that the results are in close agreement with the estimates of this effect performed through Doppler data analysis.
Pathology of Mouse Models of Accelerated Aging
Harkema, L.; Youssef, S. A.; de Bruin, A.
2016-01-01
Progeroid mouse models display phenotypes in multiple organ systems that suggest premature aging and resemble features of natural aging of both mice and humans. The prospect of a significant increase in the global elderly population within the next decades has led to the emergence of geroscience, wh
Pathology of Mouse Models of Accelerated Aging
Harkema, L; Youssef, S A; de Bruin, A|info:eu-repo/dai/nl/304837261
2016-01-01
Progeroid mouse models display phenotypes in multiple organ systems that suggest premature aging and resemble features of natural aging of both mice and humans. The prospect of a significant increase in the global elderly population within the next decades has led to the emergence of "geroscience,"
Pathology of Mouse Models of Accelerated Aging
Harkema, L; Youssef, S A; de Bruin, A
2016-01-01
Progeroid mouse models display phenotypes in multiple organ systems that suggest premature aging and resemble features of natural aging of both mice and humans. The prospect of a significant increase in the global elderly population within the next decades has led to the emergence of "geroscience,"
Cosmic Acceleration in a Model of Fourth Order Gravity
Banerjee, Shreya; Singh, Tejinder P
2015-01-01
We investigate a fourth order model of gravity, having a free length parameter, and no cosmological constant or dark energy. We consider cosmological evolution of a flat Friedmann universe in this model for the case that the length parameter is of the order of present Hubble radius. By making a suitable choice for the present value of the Hubble parameter, and value of third derivative of the scale factor (the jerk) we find that the model can explain cosmic acceleration to the same degree of accuracy as the standard concordance model. If the free length parameter is assumed to be time-dependent, and of the order of the Hubble parameter of the corresponding epoch, the model can still explain cosmic acceleration, and provides a possible resolution of the cosmic coincidence problem. We also compare redshift drift in this model, with that in the standard model.
Modeling Reliability Growth in Accelerated Stress Testing
2013-12-01
projection models for both continuous use and discrete use systems found anywhere in the literature. The review comprises a synopsis of over 80...pertaining to the research that may have been unfamiliar to the reader. The Chapter has provided a synopsis of the research accomplished in the fields of...Cox, "Analysis of the probability and risk of cause specific failure," International Journal of Radiology Oncology, Biology, Physics, vol. 29, no. 5
Hydraulic characteristics of sedimentary deposits at the J-PARC proton-accelerator, Japan
Marui Atsunao
2007-12-01
Full Text Available Hydraulic characteristics of sediments were investigated at J-PARC for the purpose of site characterization in relation with the construction of Japan's largest proton-accelerator. A total of 340 samples extracted from 9 exploratory wells were examined by standard laboratory tests and complemented with statistical analyses to quantitatively determine the main terrain attributes. Two main hydro-geological units were recognized, although a number of embedded layers defined a
multilevel aquifer. Grain-size distribution derived from sieve analysis and the coefficient of uniformity showed that soils are poorly sorted. On the other hand, hydraulic conductivity was measured by a
number of parameters such as a log-normal distribution. Conductivity was also predicted by empirical formulas, yielding values up to three orders of magnitude higher. Discrepancies were explained in
terms of soil anisotropy and intrinsic differences in the calculation methods. Based on the Shepherd's approach, a power relationship between permeability and grain size was found at 2 wells. Hydraulic
conductivity was also correlated to porosity. However, this nterdependence was not systematic and therefore, properties at many parts of the profile were considered to be randomly distributed. Finally,
logs of electrical conductivity suggested that variations of soil hydraulic properties can be associated to changes in water quality. In spite of the remaining uncertainties, results yielded from the study are useful to better understand the numerical modelling of the subsurface system in the site.
Kluchevskaya, Y. D.; Polozov, S. M.
2016-07-01
It was proposed to develop the biperiodical accelerating structure with operating frequency of 27 GHz to assess the possibility of design a compact accelerating structure for medical application. It is necessary to do the more careful simulation of variation characteristics this case because of decrease of wavelength 3-10 times in comparison with conventional structures 10 and 3 cm ranges. Results of such study are presented in the article. Also a combination of high electromagnetic fields and long pulses at a high operating frequency leads to the temperature increase in the structure, thermal deformation and significant change of the resonator characteristics, including the frequency of the RF pulse. Development results of three versions of system of temperature stabilization also discuses.
Shock Acceleration Model for the Toothbrush Radio Relic
Kang, Hyesung; Ryu, Dongsu; Jones, T. W.
2017-05-01
Although many of the observed properties of giant radio relics detected in the outskirts of galaxy clusters can be explained by relativistic electrons accelerated at merger-driven shocks, significant puzzles remain. In the case of the so-called Toothbrush relic, the shock Mach number estimated from X-ray observations ({M}{{X}}≈ 1.2{--}1.5) is substantially weaker than that inferred from the radio spectral index ({M}{rad}≈ 2.8). Toward understanding such a discrepancy, we here consider the following diffusive shock acceleration (DSA) models: (1) weak-shock models with {M}{{s}}≲ 2 and a preexisting population of cosmic-ray electrons (CRe) with a flat energy spectrum, and (2) strong-shock models with {M}{{s}}≈ 3 and either shock-generated suprathermal electrons or preexisting fossil CRe. We calculate the synchrotron emission from the accelerated CRe, following the time evolution of the electron DSA, and the subsequent radiative cooling and postshock turbulent acceleration (TA). We find that both models could reproduce reasonably well the observed integrated radio spectrum of the Toothbrush relic, but the observed broad transverse profile requires the stochastic acceleration by downstream turbulence, which we label “turbulent acceleration” or TA to distinguish it from DSA. Moreover, to account for the almost uniform radio spectral index profile along the length of the relic, the weak-shock models require a preshock region over 400 kpc with a uniform population of preexisting CRe with a high cutoff energy (≳ 40 {GeV}). Due to the short cooling time, it is challenging to explain the origin of such energetic electrons. Therefore, we suggest the strong-shock models with low-energy seed CRe (≲ 150 {MeV}) are preferred for the radio observations of this relic.
Theoretical temperature model with experimental validation for CLIC Accelerating Structures
AUTHOR|(CDS)2126138; Vamvakas, Alex; Alme, Johan
Micron level stability of the Compact Linear Collider (CLIC) components is one of the main requirements to meet the luminosity goal for the future $48 \\,km$ long underground linear accelerator. The radio frequency (RF) power used for beam acceleration causes heat generation within the aligned structures, resulting in mechanical movements and structural deformations. A dedicated control of the air- and water- cooling system in the tunnel is therefore crucial to improve alignment accuracy. This thesis investigates the thermo-mechanical behavior of the CLIC Accelerating Structure (AS). In CLIC, the AS must be aligned to a precision of $10\\,\\mu m$. The thesis shows that a relatively simple theoretical model can be used within reasonable accuracy to predict the temperature response of an AS as a function of the applied RF power. During failure scenarios or maintenance interventions, the RF power is turned off resulting in no heat dissipation and decrease in the overall temperature of the components. The theoretica...
Logic Model Checking of Unintended Acceleration Claims in Toyota Vehicles
Gamble, Ed
2012-01-01
Part of the US Department of Transportation investigation of Toyota sudden unintended acceleration (SUA) involved analysis of the throttle control software, JPL Laboratory for Reliable Software applied several techniques including static analysis and logic model checking, to the software; A handful of logic models were build, Some weaknesses were identified; however, no cause for SUA was found; The full NASA report includes numerous other analyses
Accelerating Atmospheric Modeling Through Emerging Multi-core Technologies
Linford, John Christian
2010-01-01
The new generations of multi-core chipset architectures achieve unprecedented levels of computational power while respecting physical and economical constraints. The cost of this power is bewildering program complexity. Atmospheric modeling is a grand-challenge problem that could make good use of these architectures if they were more accessible to the average programmer. To that end, software tools and programming methodologies that greatly simplify the acceleration of atmospheric modeling...
Logic Model Checking of Unintended Acceleration Claims in Toyota Vehicles
Gamble, Ed
2012-01-01
Part of the US Department of Transportation investigation of Toyota sudden unintended acceleration (SUA) involved analysis of the throttle control software, JPL Laboratory for Reliable Software applied several techniques including static analysis and logic model checking, to the software; A handful of logic models were build, Some weaknesses were identified; however, no cause for SUA was found; The full NASA report includes numerous other analyses
Ice-sheet modelling accelerated by graphics cards
Brædstrup, Christian Fredborg; Damsgaard, Anders; Egholm, David Lundbek
2014-11-01
Studies of glaciers and ice sheets have increased the demand for high performance numerical ice flow models over the past decades. When exploring the highly non-linear dynamics of fast flowing glaciers and ice streams, or when coupling multiple flow processes for ice, water, and sediment, researchers are often forced to use super-computing clusters. As an alternative to conventional high-performance computing hardware, the Graphical Processing Unit (GPU) is capable of massively parallel computing while retaining a compact design and low cost. In this study, we present a strategy for accelerating a higher-order ice flow model using a GPU. By applying the newest GPU hardware, we achieve up to 180× speedup compared to a similar but serial CPU implementation. Our results suggest that GPU acceleration is a competitive option for ice-flow modelling when compared to CPU-optimised algorithms parallelised by the OpenMP or Message Passing Interface (MPI) protocols.
Estimation of temporal gait parameters using Bayesian models on acceleration signals.
López-Nava, I H; Muñoz-Meléndez, A; Pérez Sanpablo, A I; Alessi Montero, A; Quiñones Urióstegui, I; Núñez Carrera, L
2016-01-01
The purpose of this study is to develop a system capable of performing calculation of temporal gait parameters using two low-cost wireless accelerometers and artificial intelligence-based techniques as part of a larger research project for conducting human gait analysis. Ten healthy subjects of different ages participated in this study and performed controlled walking tests. Two wireless accelerometers were placed on their ankles. Raw acceleration signals were processed in order to obtain gait patterns from characteristic peaks related to steps. A Bayesian model was implemented to classify the characteristic peaks into steps or nonsteps. The acceleration signals were segmented based on gait events, such as heel strike and toe-off, of actual steps. Temporal gait parameters, such as cadence, ambulation time, step time, gait cycle time, stance and swing phase time, simple and double support time, were estimated from segmented acceleration signals. Gait data-sets were divided into two groups of ages to test Bayesian models in order to classify the characteristic peaks. The mean error obtained from calculating the temporal gait parameters was 4.6%. Bayesian models are useful techniques that can be applied to classification of gait data of subjects at different ages with promising results.
An Accelerated Radioactive Decay (ARD) Model for Type Ia Supernovae
Rust, Bert W.; Leventhal, Marvin
2016-01-01
In 1975, Leventhal and McCall [Nature, 255, 690-692] presented a radioactive decay model 56N i --> 56Co --> 56Fe for the post-peak luminosity decay of Type I supernovae light curves, in which the two decay rates are both accelerated by a common factor. In 1976, Rust, Leventhal and McCall [Nature, 262, 118-120] used sums of exponentials fitting to confirm the acceleration hypothesis, but their result was nevertheless rejected by the astronomical community. Here, we model Type Ia light curves with a system of ODEs (describing the nuclear decays) forced by a Ni-deposition pulse modelled by a 3-parameter Weibull pdf, with all of this occuring in the center of a pre-existing, optically thick, spherical shell which thermalizes the emitted gamma rays. Fitting this model to observed light curves routinely gives fits which account for 99.9+% of the total variance in the observed record. The accelerated decay rates are so stable, for such a long time, that they must occur in an almost unchanging environment -- not it a turbulent expanding atmosphere. The amplitude of the Ni-deposition pulse indicates that its source is the fusion of hydrogen. Carbon and oxygen could not supply the large energy/nucleon that is observed. The secondary peak in the infrared light curve can be easily modelled as a light echo from dust in the back side of the pre-existing shell, and the separation between the peaks indicates a radius of ≈15 light days for the shell. The long-term stability of the acceleration suggests that it is a kinematic effect arising because the nuclear reactions occur either on the surface of a very rapidly rotating condensed object, or in a very tight orbit around such an object, like the fusion pulse in a tokomak reactor.
Computational model of sustained acceleration effects on human cognitive performance.
McKinlly, Richard A; Gallimore, Jennie J
2013-08-01
Extreme acceleration maneuvers encountered in modern agile fighter aircraft can wreak havoc on human physiology, thereby significantly influencing cognitive task performance. As oxygen content declines under acceleration stress, the activity of high order cortical tissue reduces to ensure sufficient metabolic resources are available for critical life-sustaining autonomic functions. Consequently, cognitive abilities reliant on these affected areas suffer significant performance degradations. The goal was to develop and validate a model capable of predicting human cognitive performance under acceleration stress. Development began with creation of a proportional control cardiovascular model that produced predictions of several hemodynamic parameters, including eye-level blood pressure and regional cerebral oxygen saturation (rSo2). An algorithm was derived to relate changes in rSo2 within specific brain structures to performance on cognitive tasks that require engagement of different brain areas. Data from the "precision timing" experiment were then used to validate the model predicting cognitive performance as a function of G(z) profile. The following are value ranges. Results showed high agreement between the measured and predicted values for the rSo2 (correlation coefficient: 0.7483-0.8687; linear best-fit slope: 0.5760-0.9484; mean percent error: 0.75-3.33) and cognitive performance models (motion inference task--correlation coefficient: 0.7103-0.9451; linear best-fit slope: 0.7416-0.9144; mean percent error: 6.35-38.21; precision timing task--correlation coefficient: 0.6856-0.9726; linear best-fit slope: 0.5795-1.027; mean percent error: 6.30-17.28). The evidence suggests that the model is capable of accurately predicting cognitive performance of simplistic tasks under high acceleration stress.
Model independent analysis on the slowing down of cosmic acceleration
Zhang, Ming-Jian
2016-01-01
Possible slowing down of cosmic acceleration has attracted more and more attention. However, most analysis in previous work were commonly imposed in some parametrization models. In the present paper, we investigate this subject using the the Gaussian processes (GP), providing a model-independent analysis. We carry out the reconstruction by abundant data including luminosity distance from Union2, Union2.1 compilation and gamma-ray burst, and Hubble parameter from cosmic chronometer and baryon acoustic oscillation peaks. The GP reconstructions suggest that no slowing down of cosmic acceleration is approved within 95\\% C.L. from current observational data. We also test the influence of spatial curvature and Hubble constant, finding that spatial curvature does not present significant impact on the reconstructions. However, Hubble constant strongly influence the reconstructions especially at low redshift. In order to reveal the reason of inconsistence between our reconstruction and previous parametrization constra...
Re-acceleration model for the "Toothbrush" Radio Relic
Kang, Hyesung
2016-01-01
The Toothbrush radio relic associated the merging cluster 1RXS J060303.3 is presumed to be produced by relativistic electrons accelerated at merger-driven shocks. Since the shock Mach number inferred from the observed radio spectral index, $M_{radio}\\approx 2.8$, is larger than that estimated from X-ray observations, $M_{X-ray}\\lesssim 1.5$, we consider the re-acceleration model in which a weak shock of $M_s\\approx 1.2-1.5$ sweeps through the intracluster plasma with a preshock population of relativistic electrons. We find the models with a power-law momentum spectrum with the slope, $s\\approx 4.6$, and the cutoff Lorentz factor, $\\gamma_{e,c}\\approx 7-8\\times 10^4$ can reproduce reasonably well the observed profiles of radio fluxes and integrated radio spectrum of the head portion of the Toothbrush relic. This study confirms the strong connection between the ubiquitous presence of fossil relativistic plasma originated from AGNs and the shock-acceleration model of radio relics in the intracluster medium.
Scale-free network models with accelerating growth
Huan LI
2009-01-01
Complex networks are everywhere. A typical ex-ample is software network. Basing on analyzing evolutive structure of the software networks, we consider accelerat-ing growth of network as power-law growth, which can be more easily generalized to real systems than linear growth. For accelerating growth via a power law and scale-free state with preferential linking, we focus on exploring the generic property of complex networks. Generally, two scenarios are possible. In one of them, the links are undirected. In the other scenario, the links are directed. We propose two mod-els that can predict the emergence of power-law growth and scale-free state in good agreement with these two scenar-ios and can simulate much more real systems than existing scale-free network models. Moreover, we use the obtained predictions to fit accelerating growth and the connectivity distribution of software networks describing scale-free struc-ture. The combined analytical and numerical results indicate the emergence of a novel set of models that considerably enhance our ability to understand and characterize complex networks, whose applicability reaches far beyond the quoted examples.
Re-Acceleration Model for the "Toothbrush" Radio Relic
Kang, Hyesung
2016-06-01
The Toothbrush radio relic associated with the merging cluster 1RXS J060303.3 is presumed to be produced by relativistic electrons accelerated at merger-driven shocks. Since the shock Mach number inferred from the observed radio spectral index, M_{radio}≈ 2.8, is larger than that estimated from X-ray observations, M_{X}≲ 1.5, we consider the re-acceleration model in which a weak shock of M_s≈ 1.2-1.5 sweeps through the intracluster plasma with a preshock population of relativistic electrons. We find the models with a power-law momentum spectrum with the slope, s≈ 4.6, and the cutoff Lorentz factor, γ_{e,c}≈ 7-8× 10^4 can reproduce reasonably well the observed profiles of radio fluxes and integrated radio spectrum of the head portion of the Toothbrush relic.This study confirms the strong connection between the ubiquitous presence of fossil relativistic plasma originated from AGNs and the shock-acceleration model of radio relics in the intracluster medium.
Re-Acceleration Model for the "Sausage" Radio Relic
Kang, Hyesung
2016-08-01
The Sausage radio relic is the arc-like radio structure in the cluster CIZA J2242.8+5301, whose observed properties can be best understood by synchrotron emission from relativistic electrons accelerated at a merger-driven shock.However, there remain a few puzzles that cannot be explained by the shock acceleration model with only in-situ injection. In particular, the Mach number inferred from the observed radio spectral index, M_{radio}≈ 4.6, while the Mach number estimated from X-ray observations, M_{X-ray}≈ 2.7. In an attempt to resolve such a discrepancy, here we consider the re-acceleration model in which a shock of M_s≈ 3 sweeps through the intracluster gas with a pre-existing population of relativistic electrons. We find that observed brightness profiles at multi frequencies provide strong constraints on the spectral shape of pre-existing electrons. The models with a power-law momentum spectrum with the slope, s≈ 4.1, and the cutoff Lorentz factor, γ_{e,c}≈ 3-5× 10^4, can reproduce reasonably well the observed spatial profiles of radio fluxes and integrated radio spectrum of the Sausage relic.The possible origins of such relativistic electrons in the intracluster medium remain to be investigated further.
Re-acceleration model for the `Sausage' Radio Relic
Kang, Hyesung
2016-01-01
The Sausage radio relic is the arc-like radio structure in the cluster CIZA J2242.8+5301, whose observed properties can be best understood by synchrotron emission from relativistic electrons accelerated at a merger-driven shock. However, there remain a few puzzles that cannot be explained by the shock acceleration model with only in-situ injection. In particular, the Mach number inferred from the observed radio spectral index, $M_{\\rm radio}\\approx 4.6$, while the Mach number estimated from X-ray observations, $M_{\\rm X-ray}\\approx 2.7$. In an attempt to resolve such a discrepancy, here we consider the re-acceleration model in which a shock of $M_s\\approx 3$ sweeps through the intracluster gas with a pre-existing population of relativistic electrons. We find that observed brightness profiles at multi frequencies provide strong constraints on the spectral shape of pre-existing electrons. The models with a power-law momentum spectrum with the slope, $s\\approx 4.1$, and the cutoff Lorentz factor, $\\gamma_{e,c}\\a...
石振明; 王友权; 彭铭; 刘珊
2014-01-01
distribution of landslide dams under aftershocks. The natural frequency,the damping ratio and the distribution of acceleration amplification factor of a model dam and their influencing factors are studied. The dynamic characteristic parameters of prototype landslide dams are calculated according to the similarity law. Two groups of shaking table tests are conducted to simulate the behaviors of two types of landslide dams:one with small particle size having the cohesive materials(dam I) and the other with large particle size not having the cohesive materials(dam II). The shaking table tests were conducted under different earthquake waves, different peak ground accelerations(PGA) and different water depths. The following conclusions are drawn:(1) The model dams have stable X-directional and Z-directional natural frequency and damping ratio. (2) Earlier shaking makes the natural frequency to decrease and the damping ratio to increase. The natural frequency of dam I is smaller than that of Dam II. The effects of water depth on the natural frequency of the two types of dams are different. (3) In vertical direction,acceleration amplification factor increases from the base to the top of the dam. The maximum accelerations occurred mainly on the top of the dams. In horizontal direction,the maximum accelerations occurred on the upstream and downstream surfaces of dam slopes,i.e. the surface amplification effect,which showed that the dam slope surfaces were prone to fail under earthquake action. (4) The earthquake waves with the predominant frequency close to the natural frequency of landslide dams induce the most prominent acceleration response. The earthquake in Z direction made the amplification factor of acceleration in X direction increase. The acceleration amplification factor decreases as PGA increases.
N. Harihara Krishnan
2013-05-01
Full Text Available This paper reports control of switching characteristics of silicon-based semiconductor diode using electron beam produced using linear accelerator. Conventionally, p-n junction chips of diode are exposed to gamma rays from a radioactive source or electron beam from a microtron, depending upon the required level of correction. High energy linear accelerators featuring simultaneous exposure of multiple chips are recent advancements in radiation technology. The paper presents the results of the radiation process using a 10 MeV linear accelerator as applied in industrial manufacturing of a high voltage diode (2600 V. The achieved values of reverse recovery time were found to be within the design limits. The suitability of the new process was verified by constructing the trade-off curve between the switching and conduction parameters of the diode for the complete range using large number of experimental samples. The paper summarizes the advantages of the new process over the conventional methods specifically with reference to industrial requirements. The developed process has been successfully implemented in semiconductor manufacturing.
Re-acceleration Model for Radio Relics with Spectral Curvature
Kang, Hyesung
2016-01-01
Most of the observed features of radio gischt relics such as spectral steepening across the relic width and power-law-like integrated spectrum can be adequately explained by diffusive shock acceleration (DSA) model, in which relativistic electrons are (re-)accelerated at shock waves induced in the intracluster medium. However, Kang & Ryu (2015) showed that the steep spectral curvature in the integrated spectrum above $\\sim 2$ GHz detected in the Sausage relic in cluster CIZA J2242.8+5301 may not be interpreted by simple radiative cooling of postshock electrons. In order to understand such steepening, we here consider a model in which a spherical shock sweeps through and then exits out of a finite-size cloud with fossil relativistic electrons. The ensuing integrated radio spectrum is expected to steepen much more than predicted for aging postshock electrons, since the re-acceleration stops after the cloud-crossing time. Using DSA simulations that are intended to reproduce radio observations of the Sausage ...
Wilson, Joshua Lee [Univ. of Tennessee, Knoxville, TN (United States)
2008-12-01
A new class of accelerating structures employing a uniformly twisted waveguide is investigated. Twisted waveguides of various cross-sectional geometries are considered and analyzed. It is shown that such a twisted waveguide can support waves that travel at a speed slower than the speed of light c. The slow-wave properties of twisted structures are of interest because these slow-wave electromagnetic fields can be used in applications such as electron traveling wave tubes and linear particle accelerators. Since there is no exact closed form solution for the electromagnetic fields within a twisted waveguide or cavity, several previously proposed approximate methods are examined, and more effcient approaches are developed. It is found that the existing perturbation theory methods yield adequate results for slowly twisted structures; however, our efforts here are geared toward analyzing rapidly twisted structures using modifed finite difference methods specially suited for twisted structures. Although the method can handle general twisted structures, three particular cross sections are selected as representative cases for careful analysis. First, a slowly twisted rectangular cavity is analyzed as a reference case. This is because its shape is simple and perturbation theory already gives a good approximate solution for such slow twists rates. Secondly, a symmetrically notched circular cross section is investigated, since its longitudinal cross section is comparable to the well known disk-loaded cavity (used in many practical accelerator designs, including SLAC). Finally, a "dumbbell" shaped cross section is analyzed because of its similarity to the well-known TESLA-type accelerating cavity, which is of great importance because of its wide acceptance as a superconducting cavity. To validate the results of the developed theory and our extensive simulations, the newly developed numerical models are compared to commercial codes. Also, several prototypes are developed
Papadopoulos, Agathoklis; Kostoglou, Kyriaki; Mitsis, Georgios D; Theocharides, Theocharis
2015-01-01
The use of a GPGPU programming paradigm (running CUDA-enabled algorithms on GPU cards) in biomedical engineering and biology-related applications have shown promising results. GPU acceleration can be used to speedup computation-intensive models, such as the mathematical modeling of biological systems, which often requires the use of nonlinear modeling approaches with a large number of free parameters. In this context, we developed a CUDA-enabled version of a model which implements a nonlinear identification approach that combines basis expansions and polynomial-type networks, termed Laguerre-Volterra networks and can be used in diverse biological applications. The proposed software implementation uses the GPGPU programming paradigm to take advantage of the inherent parallel characteristics of the aforementioned modeling approach to execute the calculations on the GPU card of the host computer system. The initial results of the GPU-based model presented in this work, show performance improvements over the original MATLAB model.
Theoretical analysis of acceleration measurements in a model of an operating wind turbine
White, Jonathan R.; Adams, Douglas E.; Rumsey, Mark A.
2010-04-01
Wind loading from turbulence and gusts can cause damage in horizontal axis wind turbines. These unsteady loads and the resulting damage initiation and propagation are difficult to predict. Unsteady loads enter at the rotor and are transmitted to the drivetrain. The current generation of wind turbine has drivetrain-mounted vibration and bearing temperature sensors, a nacelle-mounted inertial measurement unit, and a nacelle-mounted anemometer and wind vane. Some advanced wind turbines are also equipped with strain measurements at the root of the rotor. This paper analyzes additional measurements in a rotor blade to investigate the complexity of these unsteady loads. By identifying the spatial distribution, amplitude, and frequency bandwidth of these loads, design improvements could be facilitated to reduce uncertainties in reliability predictions. In addition, dynamic load estimates could be used in the future to control high-bandwidth aerodynamic actuators distributed along the rotor blade to reduce the saturation of slower pitch actuators currently used for wind turbine blades. Local acceleration measurements are made along a rotor blade to infer operational rotor states including deflection and dynamic modal contributions. Previous work has demonstrated that acceleration measurements can be experimentally acquired on an operating wind turbine. Simulations on simplified rotor blades have also been used to demonstrate that mean blade loading can be estimated based on deflection estimates. To successfully apply accelerometers in wind turbine applications for load identification, the spectral and spatial characteristics of each excitation source must be understood so that the total acceleration measurement can be decomposed into contributions from each source. To demonstrate the decomposition of acceleration measurements in conjunction with load estimation methods, a flexible body model has been created with MSC.ADAMSThe benefit of using a simulation model as opposed
Comparison of measured Varian Clinac 21EX and TrueBeam accelerator electron field characteristics.
Lloyd, Samantha A M; Zavgorodni, Sergei; Gagne, Isabelle M
2015-07-08
Dosimetric comparisons of radiation fields produced by Varian's newest linear accelerator, the TrueBeam, with those produced by older Varian accelerators are of interest from both practical and research standpoints. While photon fields have been compared in the literature, similar comparisons of electron fields have not yet been reported. In this work, electron fields produced by the TrueBeam are compared with those produced by Varian's Clinac 21EX accelerator. Diode measurements were taken of fields shaped with electron applicators and delivered at 100 cm SSD, as well as those shaped with photon MLCs without applicators and delivered at 70 cm SSD for field sizes ranging from 5 × 5 to 25 × 25 cm² at energies between 6 and 20 MeV. Additionally, EBT2 and EBT3 radio-chromic film measurements were taken of an MLC-shaped aperture with closed leaf pairs delivered at 70 cm SSD using 6 and 20 MeV electrons. The 6 MeV fields produced by the TrueBeam and Clinac 21EX were found to be almost indistinguishable. At higher energies, TrueBeam fields shaped by electron applicators were generally flatter and had less photon contamination compared to the Clinac 21EX. Differences in PDDs and profiles fell within 3% and 3 mm for the majority of measurements. The most notable differences for open fields occurred in the profile shoulders for the largest applicator field sizes. In these cases, the TrueBeam and Clinac 21EX data differed by as much as 8%. Our data indicate that an accurate electron beam model of the Clinac 21EX could be used as a starting point to simulate electron fields that are dosimetrically equivalent to those produced by the TrueBeam. Given that the Clinac 21EX shares head geometry with Varian's iX, Trilogy, and Novalis TX accelerators, our findings should also be applicable to these machines.
Accelerating transient simulation of linear reduced order models.
Thornquist, Heidi K.; Mei, Ting; Keiter, Eric Richard; Bond, Brad
2011-10-01
Model order reduction (MOR) techniques have been used to facilitate the analysis of dynamical systems for many years. Although existing model reduction techniques are capable of providing huge speedups in the frequency domain analysis (i.e. AC response) of linear systems, such speedups are often not obtained when performing transient analysis on the systems, particularly when coupled with other circuit components. Reduced system size, which is the ostensible goal of MOR methods, is often insufficient to improve transient simulation speed on realistic circuit problems. It can be shown that making the correct reduced order model (ROM) implementation choices is crucial to the practical application of MOR methods. In this report we investigate methods for accelerating the simulation of circuits containing ROM blocks using the circuit simulator Xyce.
YAO Chun-de; ZHOU Hong-xiu
2006-01-01
The ES (electric supercharger) driven by a high-speed brushless motor was developed to solve the problem of smoke caused by the turbocharger's sluggish response during acceleration.Its rotation speed was from 6 000 r/min to 24 000 r/min,and the maximum flux was 0.1 kg/s.The structural design of the electric supercharger is novel,which makes it easier to set the lubricating installation and to assemble.The velocity distribution at the outlet of the electric supercharger is determined by hot-wire anemometry under various rotation speeds in steady state.Furthermore,the trends of the flux and charge rate with various speeds were analyzed.In addition,the transient response was detected from the motor setup to smooth running within 10 s,15 s,20 s and 25 s respectively,and the characteristic of the transient flux is under pilot study.Research results indicate that the electric supercharger can respond rapidly with the great flux,and it is independent of the operating conditions of a diesel engine.Therefore,it is a feasible way to reduce smoke emission and improve the acceleration performance.
Characteristics of a lead slowing-down spectrometer coupled to the LANSCE accelerator
Rochman, D. [LANSCE-3, Los Alamos National Laboratory, MS H855, Los Alamos, NM 87545 (United States)]. E-mail: drochman@bnl.gov; Haight, R.C. [LANSCE-3, Los Alamos National Laboratory, MS H855, Los Alamos, NM 87545 (United States)]. E-mail: haight@lanl.gov; O' Donnell, J.M. [LANSCE-3, Los Alamos National Laboratory, MS H855, Los Alamos, NM 87545 (United States)]. E-mail: odonnell@lanl.gov; Michaudon, A. [LANSCE-3, Los Alamos National Laboratory, MS H855, Los Alamos, NM 87545 (United States)]. E-mail: michaudon@lanl.gov; Wender, S.A. [LANSCE-3, Los Alamos National Laboratory, MS H855, Los Alamos, NM 87545 (United States)]. E-mail: wender@lanl.gov; Vieira, D.J. [C-INC, Los Alamos National Laboratory, MS J514, Los Alamos, NM 87545 (United States)]. E-mail: vieira@lanl.gov; Bond, E.M. [C-INC, Los Alamos National Laboratory, MS J514, Los Alamos, NM 87545 (United States)]. E-mail: bond@lanl.gov; Bredeweg, T.A. [C-INC, Los Alamos National Laboratory, MS J514, Los Alamos, NM 87545 (United States)]. E-mail: toddb@lanl.gov; Kronenberg, A. [C-INC, Los Alamos National Laboratory, MS J514, Los Alamos, NM 87545 (United States)]. E-mail: kronenberga@mail.phy.ornl.gov; Wilhelmy, J.B. [C-INC, Los Alamos National Laboratory, MS J514, Los Alamos, NM 87545 (United States)]. E-mail: j_wilhelmy@lanl.gov; Ethvignot, T. [Commissariat a l' Energie Atomique, DIF/DPTA/Service de Physique Nucleaire, BP 12, 91680 Bruyeres-le-Cha-hat tel (France)]. E-mail: thierry.ethvignot@cea.fr; Granier, T. [Commissariat a l' Energie Atomique, DIF/DPTA/Service de Physique Nucleaire, BP 12, 91680 Bruyeres-le-Cha-hat tel (France)]. E-mail: thierry.granier@cea.fr; Petit, M. [Commissariat a l' Energie Atomique, DIF/DPTA/Service de Physique Nucleaire, BP 12, 91680 Bruyeres-le-Chatel (France)]. E-mail: michael.petit@cea.fr; Danon, Y. [Rensselaer Polytechnic Institute, Troy, New York, NY 12180 (United States)]. E-mail: danony@rpi.edu
2005-09-11
A description is given of a lead slowing-down spectrometer (LSDS) installed at the 800-MeV proton accelerator of the Los Alamos Neutron Science Center (LANSCE). The LSDS is designed to study neutron-induced fission on actinides that can only be obtained or used in small quantities. The characteristics of this LSDS (energy-time relation, energy resolution, neutron flux) are presented through simulations with MCNPX and measurements with several different methods. Results on neutron-induced fission of {sup 235}U and {sup 239}Pu with tens of micrograms and tens of nanograms, respectively, are presented. Finally, additional MCNPX calculations have been performed to simulate the measurement of the cross-section for U235m(n,f) using different target quantities and different initial isomer-to-ground state compositions.
A stochastic model of randomly accelerated walkers for human mobility
Gallotti, Riccardo; Bazzani, Armando; Rambaldi, Sandro; Barthelemy, Marc
2016-08-01
Recent studies of human mobility largely focus on displacements patterns and power law fits of empirical long-tailed distributions of distances are usually associated to scale-free superdiffusive random walks called Lévy flights. However, drawing conclusions about a complex system from a fit, without any further knowledge of the underlying dynamics, might lead to erroneous interpretations. Here we show, on the basis of a data set describing the trajectories of 780,000 private vehicles in Italy, that the Lévy flight model cannot explain the behaviour of travel times and speeds. We therefore introduce a class of accelerated random walks, validated by empirical observations, where the velocity changes due to acceleration kicks at random times. Combining this mechanism with an exponentially decaying distribution of travel times leads to a short-tailed distribution of distances which could indeed be mistaken with a truncated power law. These results illustrate the limits of purely descriptive models and provide a mechanistic view of mobility.
Zamansky, Remi; Vinkovic, Ivana; Gorokhovski, Mikhael, E-mail: ivana.vinkovic@univ-lyonl.fr [Laboratoire de Mecanique des Fluides et d' Acoustique CNRS UMR 5509 Ecole Centrale de Lyon, 36, av. Guy de Collongue, 69134 Ecully Cedex (France)
2011-12-22
Inertial particle acceleration statistics are analyzed using DNS for turbulent channel flow. Along with effects recognized in homogeneous isotropic turbulence, an additional effect is observed due to high and low speed vortical structures aligned with the channel wall. In response to those structures, particles with moderate inertia experience strong longitudinal acceleration variations. DNS is also used in order to assess LES-SSAM (Subgrid Stochastic Acceleration Model), in which an approximation to the instantaneous non-filtered velocity field is given by simulation of both, filtered and residual, accelerations. This approach allow to have access to the intermittency of the flow at subgrid scale. Advantages of LES-SSAM in predicting particle dynamics in the channel flow at a high Reynolds number are shown.
What properties of numbers are needed to model accelerated observers in relativity?
Székely, Gergely
2012-01-01
We investigate the possible structures of numbers (as physical quantities) over which accelerated observers can be modeled in special relativity. We present a general axiomatic theory of accelerated observers which has a model over every real closed field. We also show that, if we would like to model certain accelerated observers, then not every real closed field is suitable, e.g., uniformly accelerated observers cannot be modeled over the field of real algebraic numbers. Consequently, the class of fields over which uniform acceleration can be investigated is not axiomatizable in the language of ordered fields.
The Fast Linear Accelerator Modeling Engine for FRIB Online Model Service
He, Z; Davidsaver, M; Fukushima, K; Shen, G; Ikegami, M
2016-01-01
Commissioning of a large accelerator facility like FRIB needs support from an online beam dynamics model. Considering the new physics challenges of FRIB such as modeling of non-axisymmetric superconducting RF cavities and multi-charge state acceleration, there is no readily available online beam tuning code. The design code of FRIB super-conducting linac, IMPACT-Z, is not suitable for online tuning because of its code design and running speed. Therefore, the Fast Linear Accelerator Modeling Engine (FLAME), specifically designed to fulfill FRIB's online modeling challenges, is proposed. The physics model of FLAME, especially its novel way of modeling non-axisymmetric superconducting RF cavities using a multipole expansion based thin-lens kick model, is discussed in detail, and the benchmark results against FRIB design code is presented, after which the software design strategy of FLAME and its execution speed is presented.
Acrylamide induces accelerated endothelial aging in a human cell model.
Sellier, Cyril; Boulanger, Eric; Maladry, François; Tessier, Frédéric J; Lorenzi, Rodrigo; Nevière, Rémi; Desreumaux, Pierre; Beuscart, Jean-Baptiste; Puisieux, François; Grossin, Nicolas
2015-09-01
Acrylamide (AAM) has been recently discovered in food as a Maillard reaction product. AAM and glycidamide (GA), its metabolite, have been described as probably carcinogenic to humans. It is widely established that senescence and carcinogenicity are closely related. In vitro, endothelial aging is characterized by replicative senescence in which primary cells in culture lose their ability to divide. Our objective was to assess the effects of AAM and GA on human endothelial cell senescence. Human umbilical vein endothelial cells (HUVECs) cultured in vitro were used as model. HUVECs were cultured over 3 months with AAM or GA (1, 10 or 100 μM) until growth arrest. To analyze senescence, β-galactosidase activity and telomere length of HUVECs were measured by cytometry and semi-quantitative PCR, respectively. At all tested concentrations, AAM or GA reduced cell population doubling compared to the control condition (p < 0.001). β-galactosidase activity in endothelial cells was increased when exposed to AAM (≥10 μM) or GA (≥1 μM) (p < 0.05). AAM (≥10 μM) or GA (100 μM) accelerated telomere shortening in HUVECs (p < 0.05). In conclusion, in vitro chronic exposure to AAM or GA at low concentrations induces accelerated senescence. This result suggests that an exposure to AAM might contribute to endothelial aging.
Modeling Characteristics Of Surfaces For Radar Polarimetry
Van Zyl, Jakob J.; Zebker, Howard A.; Durden, Stephen L.
1992-01-01
Paper reviews mathematical models of polarimetric radar backscattering characteristics of various types of terrain; forests, grasslands, and lava fields. Represents approach to imaging radar polarimetry in which one accumulates models predicting realistic polarization signatures and represent distinct scattering processes, without attempting full vector solutions of Maxwell's equations in all cases. Idea to develop ability to invert models to identify unknown terrain depicted in polarimetric radar images. Describes models, major scattering characteristics predicted by models, and interpretation of characteristics in terms of dominant scattering mechanisms. Models predict realistic polarization signatures.
Modelling CH$_3$OH masers: Sobolev approximation and accelerated lambda iteration method
Nesterenok, Aleksandr
2015-01-01
A simple one-dimensional model of CH$_3$OH maser is considered. Two techniques are used for the calculation of molecule level populations: the accelerated lambda iteration (ALI) method and the large velocity gradient (LVG), or Sobolev, approximation. The LVG approximation gives accurate results provided that the characteristic dimensions of the medium are larger than 5-10 lengths of the resonance region. We presume that this condition can be satisfied only for the largest observed maser spot distributions. Factors controlling the pumping of class I and class II methanol masers are considered.
Chaikovska, I.; Chehab, R.; Artru, X.; Shchagin, A. V.
2017-07-01
The applicability of X-ray radiation for the observation of accelerated particle beam profiles is studied. Three types of quasi-monochromatic X-ray radiation excited by the particles in crystals are considered: characteristic X-ray radiation, parametric X-ray radiation, diffracted transition X-ray radiation. Radiation is collected at the right angle to the particle beam direction. It is show that the most intensive differential yield of X-ray radiation from Si crystal can be provided by characteristic radiation at incident electron energies up to tens MeV, by parametric radiation at incident electron energies from tens to hundreds MeV, by diffracted transition X-ray radiation at GeV and multi-GeV electron energies. Therefore these kinds of radiation are proposed for application to beam profile observation in the corresponding energy ranges of incident electrons. Some elements of X-ray optics for observation of the beam profile are discussed. The application of the DTR as a source of powerful tunable monochromatic linearly polarized X-ray beam excited by a multi-GeV electron beam on the crystal surface is proposed.
Modeling laser wakefield accelerators in a Lorentz boosted frame
Vay, J.-L.; Geddes, C.G.R.; Cormier-Michel, E.; Grote, D.P.
2010-09-15
Modeling of laser-plasma wakefield accelerators in an optimal frame of reference [1] is shown to produce orders of magnitude speed-up of calculations from first principles. Obtaining these speedups requires mitigation of a high frequency instability that otherwise limits effectiveness in addition to solutions for handling data input and output in a relativistically boosted frame of reference. The observed high-frequency instability is mitigated using methods including an electromagnetic solver with tunable coefficients, its extension to accomodate Perfectly Matched Layers and Friedman's damping algorithms, as well as an efficient large bandwidth digital filter. It is shown that choosing theframe of the wake as the frame of reference allows for higher levels of filtering and damping than is possible in other frames for the same accuracy. Detailed testing also revealed serendipitously the existence of a singular time step at which the instability level is minimized, independently of numerical dispersion, thus indicating that the observed instability may not be due primarily to Numerical Cerenkov as has been conjectured. The techniques developed for Cerenkov mitigation prove nonetheless to be very efficient at controlling the instability. Using these techniques, agreement at the percentage level is demonstrated between simulations using different frames of reference, with speedups reaching two orders of magnitude for a 0.1 GeV class stages. The method then allows direct and efficient full-scale modeling of deeply depleted laser-plasma stages of 10 GeV-1 TeV for the first time, verifying the scaling of plasma accelerators to very high energies. Over 4, 5 and 6 orders of magnitude speedup is achieved for the modeling of 10 GeV, 100 GeV and 1 TeV class stages, respectively.
Modeling laser wakefield accelerators in a Lorentz boosted frame
Vay, J.-L.; Geddes, C.G.R.; Cormier-Michel, E.; Grotec, D. P.
2010-06-15
Modeling of laser-plasma wakefield accelerators in an optimal frame of reference is shown to produce orders of magnitude speed-up of calculations from first principles. Obtaining these speedups requires mitigation of a high-frequency instability that otherwise limits effectiveness in addition to solutions for handling data input and output in a relativistically boosted frame of reference. The observed high-frequency instability is mitigated using methods including an electromagnetic solver with tunable coefficients, its extension to accomodate Perfectly Matched Layers and Friedman's damping algorithms, as well as an efficient large bandwidth digital filter. It is shown that choosing the frame of the wake as the frame of reference allows for higher levels of filtering and damping than is possible in other frames for the same accuracy. Detailed testing also revealed serendipitously the existence of a singular time step at which the instability level is minimized, independently of numerical dispersion, thus indicating that the observed instability may not be due primarily to Numerical Cerenkov as has been conjectured. The techniques developed for Cerenkov mitigation prove nonetheless to be very efficient at controlling the instability. Using these techniques, agreement at the percentage level is demonstrated between simulations using different frames of reference, with speedups reaching two orders of magnitude for a 0.1 GeV class stages. The method then allows direct and efficient full-scale modeling of deeply depleted laser-plasma stages of 10 GeV-1 TeV for the first time, verifying the scaling of plasma accelerators to very high energies. Over 4, 5 and 6 orders of magnitude speedup is achieved for the modeling of 10 GeV, 100 GeV and 1 TeV class stages, respectively.
Accelerated failure time model under general biased sampling scheme.
Kim, Jane Paik; Sit, Tony; Ying, Zhiliang
2016-07-01
Right-censored time-to-event data are sometimes observed from a (sub)cohort of patients whose survival times can be subject to outcome-dependent sampling schemes. In this paper, we propose a unified estimation method for semiparametric accelerated failure time models under general biased estimating schemes. The proposed estimator of the regression covariates is developed upon a bias-offsetting weighting scheme and is proved to be consistent and asymptotically normally distributed. Large sample properties for the estimator are also derived. Using rank-based monotone estimating functions for the regression parameters, we find that the estimating equations can be easily solved via convex optimization. The methods are confirmed through simulations and illustrated by application to real datasets on various sampling schemes including length-bias sampling, the case-cohort design and its variants. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Image processing algorithm acceleration using reconfigurable macro processor model
孙广富; 陈华明; 卢焕章
2004-01-01
The concept and advantage of reconfigurable technology is introduced. A kind of processor architecture of reconfigurable macro processor (RMP) model based on FPGA array and DSP is put forward and has been implemented.Two image algorithms are developed: template-based automatic target recognition and zone labeling. One is estimating for motion direction in the infrared image background, another is line picking-up algorithm based on image zone labeling and phase grouping technique. It is a kind of "hardware" function that can be called by the DSP in high-level algorithm.It is also a kind of hardware algorithm of the DSP. The results of experiments show the reconfigurable computing technology based on RMP is an ideal accelerating means to deal with the high-speed image processing tasks. High real time performance is obtained in our two applications on RMP.
A GPGPU accelerated modeling environment for quantitatively characterizing karst systems
Myre, J. M.; Covington, M. D.; Luhmann, A. J.; Saar, M. O.
2011-12-01
The ability to derive quantitative information on the geometry of karst aquifer systems is highly desirable. Knowing the geometric makeup of a karst aquifer system enables quantitative characterization of the systems response to hydraulic events. However, the relationship between flow path geometry and karst aquifer response is not well understood. One method to improve this understanding is the use of high speed modeling environments. High speed modeling environments offer great potential in this regard as they allow researchers to improve their understanding of the modeled karst aquifer through fast quantitative characterization. To that end, we have implemented a finite difference model using General Purpose Graphics Processing Units (GPGPUs). GPGPUs are special purpose accelerators which are capable of high speed and highly parallel computation. The GPGPU architecture is a grid like structure, making it is a natural fit for structured systems like finite difference models. To characterize the highly complex nature of karst aquifer systems our modeling environment is designed to use an inverse method to conduct the parameter tuning. Using an inverse method reduces the total amount of parameter space needed to produce a set of parameters describing a system of good fit. Systems of good fit are determined with a comparison to reference storm responses. To obtain reference storm responses we have collected data from a series of data-loggers measuring water depth, temperature, and conductivity at locations along a cave stream with a known geometry in southeastern Minnesota. By comparing the modeled response to those of the reference responses the model parameters can be tuned to quantitatively characterize geometry, and thus, the response of the karst system.
A class of effective field theory models of cosmic acceleration
Bloomfield, Jolyon K.; Flanagan, Éanna É., E-mail: jkb84@cornell.edu, E-mail: eef3@cornell.edu [Center for Radiophysics and Space Research, Cornell University, Space Science Building, Ithaca, NY 14853 (United States)
2012-10-01
We explore a class of effective field theory models of cosmic acceleration involving a metric and a single scalar field. These models can be obtained by starting with a set of ultralight pseudo-Nambu-Goldstone bosons whose couplings to matter satisfy the weak equivalence principle, assuming that one boson is lighter than all the others, and integrating out the heavier fields. The result is a quintessence model with matter coupling, together with a series of correction terms in the action in a covariant derivative expansion, with specific scalings for the coefficients. After eliminating higher derivative terms and exploiting the field redefinition freedom, we show that the resulting theory contains nine independent free functions of the scalar field when truncated at four derivatives. This is in contrast to the four free functions found in similar theories of single-field inflation, where matter is not present. We discuss several different representations of the theory that can be obtained using the field redefinition freedom. For perturbations to the quintessence field today on subhorizon lengthscales larger than the Compton wavelength of the heavy fields, the theory is weakly coupled and natural in the sense of t'Hooft. The theory admits a regime where the perturbations become modestly nonlinear, but very strong nonlinearities lie outside its domain of validity.
Neural Networks for Modeling and Control of Particle Accelerators
Edelen, A.L.; Chase, B.E.; Edstrom, D.; Milton, S.V.; Stabile, P.
2016-01-01
We describe some of the challenges of particle accelerator control, highlight recent advances in neural network techniques, discuss some promising avenues for incorporating neural networks into particle accelerator control systems, and describe a neural network-based control system that is being developed for resonance control of an RF electron gun at the Fermilab Accelerator Science and Technology (FAST) facility, including initial experimental results from a benchmark controller.
Modelling supported driving as an optimal control cycle: Framework and model characteristics
Wang, Meng; Daamen, Winnie; Hoogendoorn, Serge P; van Arem, Bart
2014-01-01
Driver assistance systems support drivers in operating vehicles in a safe, comfortable and efficient way, and thus may induce changes in traffic flow characteristics. This paper puts forward a receding horizon control framework to model driver assistance and cooperative systems. The accelerations of automated vehicles are controlled to optimise a cost function, assuming other vehicles driving at stationary conditions over a prediction horizon. The flexibility of the framework is demonstrated with controller design of Adaptive Cruise Control (ACC) and Cooperative ACC (C-ACC) systems. The proposed ACC and C-ACC model characteristics are investigated analytically, with focus on equilibrium solutions and stability properties. The proposed ACC model produces plausible human car-following behaviour and is unconditionally locally stable. By careful tuning of parameters, the ACC model generates similar stability characteristics as human driver models. The proposed C-ACC model results in convective downstream and abso...
Huang Xian-Bin; Chen Guang-Hua; Zhang Zheng-Wei; Ouyang Kai; Li Jun; Zhang Zhao-Hui; Zhou Rong-Guo; Wang Gui-Lin; Yang Li-Bing; Li Jing; Zhou Shao-Tong; Ren Xiao-Dong; Zhang Si-Qun; Dan Jia-Kun; Cai Hong-Chun; Duan Shu-Chao
2012-01-01
We investigated the radiation characteristics and implosion dynamics of low-wire-number cylindrical tungsten wire array Z-pinches on the YANG accelerator with a peak current 0.8-1.1 M A and a rising time～90 ns.The arrays are made up of(8-32)x5 μm wires 6/10 mm in diameter and 15 mm in height.The highest X-ray power obtained in the experiments was about 0.37 TW with the total radiation energy～13 kJ and the energy conversion efficiency～9％(24x5 μm wires,6 mm in diameter).Most of the X-ray emissions from tungsten Z-pinch plasmas were distributed in the spectral band of 100-600 eV,peaked at 250 and 375 eV.The dominant wavelengths of the wire ablation and the magneto-Rayleigh-Taylor instability were found and analyzed through measuring the time-gated self-emission and laser interferometric images.Through analyzing the implosion trajectories obtained by an optical streak camera,the run-in velocities of the Z-pinch plasmas at the end of the implosion phase were determined to be about(1.3-2.1)x 107 cm/s.
Ureña-López, L. Arturo; Robles, Victor H.; Matos, T.
2017-08-01
Recent analysis of the rotation curves of a large sample of galaxies with very diverse stellar properties reveals a relation between the radial acceleration purely due to the baryonic matter and the one inferred directly from the observed rotation curves. Assuming the dark matter (DM) exists, this acceleration relation is tantamount to an acceleration relation between DM and baryons. This leads us to a universal maximum acceleration for all halos. Using the latter in DM profiles that predict inner cores implies that the central surface density μDM=ρsrs must be a universal constant, as suggested by previous studies of selected galaxies, revealing a strong correlation between the density ρs and scale rs parameters in each profile. We then explore the consequences of the constancy of μDM in the context of the ultralight scalar field dark matter model (SFDM). We find that for this model μDM=648 M⊙ pc-2 and that the so-called WaveDM soliton profile should be a universal feature of the DM halos. Comparing with the data from the Milky Way and Andromeda satellites, we find that they are all consistent with a boson mass of the scalar field particle of the order of 10-21 eV /c2, which puts the SFDM model in agreement with recent cosmological constraints.
Full velocity difference and acceleration model for a car-following theory
Yu, Shaowei; Liu, Qingling; Li, Xiuhai
2013-05-01
In order to describe the car-following behavior more actually in real traffic, a full velocity difference and acceleration model (for short, FVDAM) is proposed by synthetically taking into account headway, velocity difference and acceleration of the leading car on the basis of full velocity difference model. The analytical method and numerical simulation results show that the proposed model can describe the phase transition of traffic flow and estimate the evolution of traffic congestion, that incorporating the acceleration of the leading car into car-following model can stabilize traffic flow, suppress the traffic jam and increase capacity, and that the following car in FVDAM can accelerate more quickly than in FVDM.
Advanced Computing Tools and Models for Accelerator Physics
Ryne, Robert; Ryne, Robert D.
2008-06-11
This paper is based on a transcript of my EPAC'08 presentation on advanced computing tools for accelerator physics. Following an introduction I present several examples, provide a history of the development of beam dynamics capabilities, and conclude with thoughts on the future of large scale computing in accelerator physics.
Characteristic parameters of 6--21 MeV electron beams from a 21 MeV linear accelerator
Al-Ghazi, M.S.A.L. (Department of Medical Physics, Thunder Bay Regional Cancer Centre, Ontario Cancer Treatment and Research Foundation, Thunder Bay, Ontario P7A 7T1, (Canada) Department of Physics, Lakehead University, Thunder Bay, Ontario P7B 5E1, (Canada) Lingman, D. Department of Medical Physics, Thunder Bay Regional Cancer Centre, Ontario Cancer Treatment and Research Foundation, Thunder Bay, Ontario P7A 7T1, (Canada) Department of Computer Science, Lakehead University, Thunder Bay, Ontario P7B 5E1, (Canada)); Gilbert, L.D. (Thekkumthala, J. Department of Medical Physics, Thunder Bay Regional Cancer Centre, Ontario Cancer Treatment and Research Foundation, Thunder Bay, Ontario P7A 7T1, (Canada))
1991-07-01
Dosimetry measurements have been carried out for the electron beams produced by a linear accelerator at energies 6, 8, 10, 14, 18, and 21 MeV. Characteristic parameters of the central axis dose distributions were derived and compared to corresponding values of electron beams from other accelerators in clinical use where such a comparison is appropriate. A comprehensive set of dosimetric parameters is provided for electron beam treatment planning. The data include central axis depth dose, range--energy parameters, beam penumbra and uniformity.
Forecasting characteristic earthquakes in a minimalist model
Vázquez-Prada, M.; Pacheco, A.; González, Á.
2003-01-01
Using error diagrams, we quantify the forecasting of characteristic-earthquake occurence in a recently introduced minimalist model. Initially we connect the earthquake alarm at a fixed time after the occurence of a characteristic event. The evaluation of this strategy leads to a one-dimensional n...
Modeling classical and quantum radiation from laser-plasma accelerators
M. Chen
2013-03-01
Full Text Available The development of models and the “Virtual Detector for Synchrotron Radiation” (vdsr code that accurately describe the production of synchrotron radiation are described. These models and code are valid in the classical and linear (single-scattering quantum regimes and are capable of describing radiation produced from laser-plasma accelerators (LPAs through a variety of mechanisms including betatron radiation, undulator radiation, and Thomson/Compton scattering. Previous models of classical synchrotron radiation, such as those typically used for undulator radiation, are inadequate in describing the radiation spectra from electrons undergoing small numbers of oscillations. This is due to an improper treatment of a mathematical evaluation at the end points of an integration that leads to an unphysical plateau in the radiation spectrum at high frequencies, the magnitude of which increases as the number of oscillation periods decreases. This is important for betatron radiation from LPAs, in which the betatron strength parameter is large but the number of betatron periods is small. The code vdsr allows the radiation to be calculated in this regime by full integration over each electron trajectory, including end-point effects, and this code is used to calculate betatron radiation for cases of experimental interest. Radiation from Thomson scattering and Compton scattering is also studied with vdsr. For Thomson scattering, radiation reaction is included by using the Sokolov method for the calculation of the electron dynamics. For Compton scattering, quantum recoil effects are considered in vdsr by using Monte Carlo methods. The quantum calculation has been benchmarked with the classical calculation in a classical regime.
Acacia honey accelerates in vitro corneal ulcer wound healing model.
Abd Ghafar, Norzana; Ker-Woon, Choy; Hui, Chua Kien; Mohd Yusof, Yasmin Anum; Wan Ngah, Wan Zurinah
2016-07-29
The study aimed to evaluate the effects of Acacia honey (AH) on the migration, differentiation and healing properties of the cultured rabbit corneal fibroblasts. Stromal derived corneal fibroblasts from New Zealand White rabbit (n = 6) were isolated and cultured until passage 1. In vitro corneal ulcer was created using a 4 mm corneal trephine onto confluent cultures and treated with basal medium (FD), medium containing serum (FDS), with and without 0.025 % AH. Wound areas were recorded at day 0, 3 and 6 post wound creation. Genes and proteins associated with wound healing and differentiation such as aldehyde dehydrogenase (ALDH), vimentin, alpha-smooth muscle actin (α-SMA), collagen type I, lumican and matrix metalloproteinase 12 (MMP12) were evaluated using qRT-PCR and immunocytochemistry respectively. Cells cultured with AH-enriched FDS media achieved complete wound closure at day 6 post wound creation. The cells cultured in AH-enriched FDS media increased the expression of vimentin, collagen type I and lumican genes and decreased the ALDH, α-SMA and MMP12 gene expressions. Protein expression of ALDH, vimentin and α-SMA were in accordance with the gene expression analyses. These results demonstrated AH accelerate corneal fibroblasts migration and differentiation of the in vitro corneal ulcer model while increasing the genes and proteins associated with stromal wound healing.
Effect of Particle Acceleration Process on the Flare Characteristics of Blazars
S. Bhattacharyya; S. Sahayanathan; C. L. Kaul
2002-03-01
Following the kinetic equation approach, we study the flare processes in blazars in the optical-to-X-ray region, considering energy dependent acceleration time-scale of electrons and synchrotron and adiabatic cooling as their dominant energy loss processes.
Mashchenko, A. I.; Vintizenko, I. I.
2016-06-01
Various types of high-current nanosecond accelerators are simulated numerically using an equivalent circuit representation. The influence of pulse forming line switch inductance on the amplitude and waveform of output voltage and current pulses is analyzed.
A new PMHS model for lumbar spine injuries during vertical acceleration.
Stemper, Brian D; Storvik, Steven G; Yoganandan, Narayan; Baisden, Jamie L; Fijalkowski, Ronald J; Pintar, Frank A; Shender, Barry S; Paskoff, Glenn R
2011-08-01
Ejection from military aircraft exerts substantial loads on the lumbar spine. Fractures remain common, although the overall survivability of the event has considerably increased over recent decades. The present study was performed to develop and validate a biomechanically accurate experimental model for the high vertical acceleration loading to the lumbar spine that occurs during the catapult phase of aircraft ejection. The model consisted of a vertical drop tower with two horizontal platforms attached to a monorail using low friction linear bearings. A total of four human cadaveric spine specimens (T12-L5) were tested. Each lumbar column was attached to the lower platform through a load cell. Weights were added to the upper platform to match the thorax, head-neck, and upper extremity mass of a 50th percentile male. Both platforms were raised to the drop height and released in unison. Deceleration characteristics of the lower platform were modulated by foam at the bottom of the drop tower. The upper platform applied compressive inertial loads to the top of the specimen during deceleration. All specimens demonstrated complex bending during ejection simulations, with the pattern dependent upon the anterior-posterior location of load application. The model demonstrated adequate inter-specimen kinematic repeatability on a spinal level-by-level basis under different subfailure loading scenarios. One specimen was then exposed to additional tests of increasing acceleration to induce identifiable injury and validate the model as an injury-producing system. Multiple noncontiguous vertebral fractures were obtained at an acceleration of 21 g with 488 g/s rate of onset. This clinically relevant trauma consisted of burst fracture at L1 and wedge fracture at L4. Compression of the vertebral body approached 60% during the failure test, with -6,106 N axial force and 168 Nm flexion moment. Future applications of this model include developing a better understanding of the vertebral
Hu, Li; Wang, Juan; Zhou, Xin; Xiong, Zehuan; Zhao, Jiajia; Yu, Ran; Huang, Fang; Zhang, Handong; Chen, Lili
2016-09-12
Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we investigated the roles of ASCs-derived exosomes (ASCs-Exos) in cutaneous wound healing. We found that ASCs-Exos could be taken up and internalized by fibroblasts to stimulate cell migration, proliferation and collagen synthesis in a dose-dependent manner, with increased genes expression of N-cadherin, cyclin-1, PCNA and collagen I, III. In vivo tracing experiments demonstrated that ASCs-Exos can be recruited to soft tissue wound area in a mouse skin incision model and significantly accelerated cutaneous wound healing. Histological analysis showed increased collagen I and III production by systemic administration of exosomes in the early stage of wound healing, while in the late stage, exosomes might inhibit collagen expression to reduce scar formation. Collectively, our findings indicate that ASCs-Exos can facilitate cutaneous wound healing via optimizing the characteristics of fibroblasts. Our results provide a new perspective and therapeutic strategy for the use of ASCs-Exos in soft tissue repair.
Hu, Li; Wang, Juan; Zhou, Xin; Xiong, Zehuan; Zhao, Jiajia; Yu, Ran; Huang, Fang; Zhang, Handong; Chen, Lili
2016-01-01
Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we investigated the roles of ASCs-derived exosomes (ASCs-Exos) in cutaneous wound healing. We found that ASCs-Exos could be taken up and internalized by fibroblasts to stimulate cell migration, proliferation and collagen synthesis in a dose-dependent manner, with increased genes expression of N-cadherin, cyclin-1, PCNA and collagen I, III. In vivo tracing experiments demonstrated that ASCs-Exos can be recruited to soft tissue wound area in a mouse skin incision model and significantly accelerated cutaneous wound healing. Histological analysis showed increased collagen I and III production by systemic administration of exosomes in the early stage of wound healing, while in the late stage, exosomes might inhibit collagen expression to reduce scar formation. Collectively, our findings indicate that ASCs-Exos can facilitate cutaneous wound healing via optimizing the characteristics of fibroblasts. Our results provide a new perspective and therapeutic strategy for the use of ASCs-Exos in soft tissue repair. PMID:27615560
A class of additive-accelerated means regression models for recurrent event data
无
2010-01-01
In this article, we propose a class of additive-accelerated means regression models for analyzing recurrent event data. The class includes the proportional means model, the additive rates model, the accelerated failure time model, the accelerated rates model and the additive-accelerated rate model as special cases. The new model offers great flexibility in formulating the effects of covariates on the mean functions of counting processes while leaving the stochastic structure completely unspecified. For the inference on the model parameters, estimating equation approaches are derived and asymptotic properties of the proposed estimators are established. In addition, a technique is provided for model checking. The finite-sample behavior of the proposed methods is examined through Monte Carlo simulation studies, and an application to a bladder cancer study is illustrated.
Executable SysML Model Development Accelerator for the Constellation Program Project
National Aeronautics and Space Administration — The proposed project is aimed at investigating ways to accelerate the creation of SysML based models that can be used for model checking and more generally for...
Curriculum innovation in an accelerated BSN program: the ACE Model.
Suplee, Patricia D; Glasgow, Mary Ellen
2008-01-01
As the demand for registered nurses continues to rise, so too has the creation of accelerated baccalaureate nursing programs for second-degree students. This article describes an 11-month Accelerated Career Entry (ACE) Nursing Program's innovative curriculum design, which has a heavy emphasis on technology, professional socialization, and the use of a standardized patient experience as a form of summative evaluation. In addition, challenges of this program are presented. Since 2002, the ACE Program has graduated over 500 students with an average first-time NCLEX pass rate of 95-100%. Although the number of graduates from accelerated programs does not solve the severe nursing shortage, the contributions of these intelligent, assertive, pioneering graduates are important for health care.
HVDC System Characteristics and Simulation Models
Moon, S.I.; Han, B.M.; Jang, G.S. [Electric Enginnering and Science Research Institute, Seoul (Korea)
2001-07-01
This report deals with the AC-DC power system simulation method by PSS/E and EUROSTAG for the development of a strategy for the reliable operation of the Cheju-Haenam interconnected system. The simulation using both programs is performed to analyze HVDC simulation models. In addition, the control characteristics of the Cheju-Haenam HVDC system as well as Cheju AC system characteristics are described in this work. (author). 104 figs., 8 tabs.
WANG Ronghua; FEI Heliang
2004-01-01
In this note, the tampered failure rate model is generalized from the step-stress accelerated life testing setting to the progressive stress accelerated life testing for the first time. For the parametric setting where the scale parameter satisfying the equation of the inverse power law is Weibull, maximum likelihood estimation is investigated.
呼义翔; 雷天时; 吴撼宇; 郭宁; 韩娟娟; 邱爱慈; 王亮平; 黄涛; 丛培天; 张信军; 李岩; 曾正中; 孙铁平
2011-01-01
The transmission-line-circuit model of the Z accelerator, developed originally by W. A. STYGAR, P. A. CORCORAN, et al., is revised. The revised model uses different calculations for the electron loss and flow impedance in the magnetically insulated transmission line system of the Z accelerator before and after magnetic insulation is established. By including electron pressure and zero electric field at the cathode, a closed set of equations is obtained at each time step, and dynamic shunt resistance （used to represent any electron loss to the anode） and flow impedance are solved, which have been incorporated into the transmission line code for simulations of the vacuum section in the Z accelerator. Finally, the results are discussed in comparison with earlier findings to show the effectiveness and limitations of the model.
2016-09-28
Aviation accident investigators often conduct qualitative perceptual analyses of mishaps when spatial disorientation is inferred as a cause. We have...developed a quantitative perceptual model of human spatial orientation and have employed it to evaluate data from a variety of acceleration situations, in...Research and Material Command (USAMRMC; In-House Laboratory Independent Research), Small Business Innovative Research program (PEO Aviation), and the
Comparing acceleration and speed tuning in macaque MT: physiology and modeling.
Price, N S C; Ono, S; Mustari, M J; Ibbotson, M R
2005-11-01
Studies of individual neurons in area MT have traditionally investigated their sensitivity to constant speeds. We investigated acceleration sensitivity in MT neurons by comparing their responses to constant steps and linear ramps in stimulus speed. Speed ramps constituted constant accelerations and decelerations between 0 and 240 degrees /s. Our results suggest that MT neurons do not have explicit acceleration sensitivity, although speed changes affected their responses in three main ways. First, accelerations typically evoked higher responses than the corresponding deceleration rate at all rates tested. We show that this can be explained by adaptation mechanisms rather than differential processing of positive and negative speed gradients. Second, we inferred a cell's preferred speed from the responses to speed ramps by finding the stimulus speed at the latency-adjusted time when response amplitude peaked. In most cells, the preferred speeds inferred from deceleration were higher than those for accelerations of the same rate or from steps in stimulus speed. Third, neuron responses to speed ramps were not well predicted by the transient or sustained responses to steps in stimulus speed. Based on these findings, we developed a model incorporating adaptation and a neuron's speed tuning that predicted the higher inferred speeds and lower spike rates for deceleration responses compared with acceleration responses. This model did not predict acceleration-specific responses, in accordance with the lack of acceleration sensitivity in the neurons. The outputs of this single-cell model were passed to a population-vector-based model used to estimate stimulus speed and acceleration. We show that such a model can accurately estimate relative speed and acceleration using information from the population of neurons in area MT.
Modeling of Electromagnetic Heating in RF Copper Accelerating Cavities
Awida, M. H. [Fermilab; Gonin, I. [Fermilab; Romanov, Romanov [Fermilab; Khabiboulline, T. [Fermilab; Yakovlev, V. [Fermilab
2016-01-17
Electromagnetic heating is a critical issue in normal conducting copper RF cavities that are employed in particle accelerators. With several tens to hundreds of kilowatts dissipated RF power, there must be an effective cooling scheme whether it is water or air based or even a combination of both. In this paper we investigate the electromagnetic heating in multiple cavities that were designed at Fermilab exploring how the electromagnetic and thermal analyses are coupled together to properly design the cooling of such cavities.
Final Report for "Modeling Electron Cloud Diagnostics for High-Intensity Proton Accelerators"
Seth A Veitzer
2009-09-25
Electron clouds in accelerators such as the ILC degrade beam quality and limit operating efficiency. The need to mitigate electron clouds has a direct impact on the design and operation of these accelerators, translating into increased cost and reduced performance. Diagnostic techniques for measuring electron clouds in accelerating cavities are needed to provide an assessment of electron cloud evolution and mitigation. Accurate numerical modeling of these diagnostics is needed to validate the experimental techniques. In this Phase I, we developed detailed numerical models of microwave propagation through electron clouds in accelerating cavities with geometries relevant to existing and future high-intensity proton accelerators such as Project X and the ILC. Our numerical techniques and simulation results from the Phase I showed that there was a high probability of success in measuring both the evolution of electron clouds and the effects of non-uniform electron density distributions in Phase II.
kun, Chen; YanXiang, Yu
2016-04-01
Considering the geological context, focal mechanism solutions, aftershock distribution and attenuation characteristics of the ground motion in western China, shakemaps of PGA (Peak Ground Acceleration) for The Ludian Ms6.5 earthquake on 3 Aug 2014 was acquired, in which the Mothed of rapid generation ShakeMaps considering site effects was used, and the peak ground acceleration of 62 stations for this earthquake was used as interpolation. Then, distribution of PGA was amended by using PGA observations to correct system bias of theoretical estimates in the area without PGA observations. The results show that the attenuation of ground motion with distance for this earthquake was faster than that of Wang Su-Yun in 2000; the result of bias-corrected was more consistent with attenuation law of this earthquake. After adjusting, for the area with PGA greater than 40 cm / s2 was nearly 8000 km2, which was is reduced by about 40%.
Modelling of dc characteristics for granular semiconductors
Varpula, Aapo; Sinkkonen, Juha; Novikov, Sergey, E-mail: aapo.varpula@tkk.f [Department of Micro and Nanosciences, Aalto University, PO Box 13500, FI-00076 Aalto, Espoo (Finland)
2010-11-01
The dc characteristics of granular n-type semiconductors are calculated analytically with the drift-diffusion theory. Electronic trapping at the grain boundaries (GBs) is taken into account. The use of quadratic and linear GB potential profiles in the calculation is compared. The analytical model is verified with numerical simulation performed by SILVACO ATLAS. The agreement between the analytical and numerical results is excellent in a large voltage range. The results show that electronic trapping at the GBs has a remarkable effect on the highly nonlinear I-V characteristics of the material.
Abdulkerim Gok; David K Ngendahimana; Cara L Fagerholm; Roger H French; Jiayang Sun; Laura S Bruckman
2017-01-01
Accelerated weathering exposures were performed on poly(ethylene-terephthalate) (PET) films. Longitudinal multi-level predictive models as a function of PET grades and exposure types were developed for the change in yellowness index...
Accelerated testing statistical models, test plans, and data analysis
Nelson, Wayne B
2009-01-01
The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. "". . . a goldmine of knowledge on accelerated life testing principles and practices . . . one of the very few capable of advancing the science of reliability. It definitely belongs in every bookshelf on engineering.""-Dev G.
Common Mathematical Model of Fatigue Characteristics
Z. Maléř
2004-01-01
Full Text Available This paper presents a new common mathematical model which is able to describe fatigue characteristics in the whole necessary range by one equation only:log N = A(R + B(R ∙ log Sawhere A(R = AR2 + BR + C and B(R = DR2 + AR + F.This model was verified by five sets of fatigue data taken from the literature and by our own three additional original fatigue sets. The fatigue data usually described the region of N 104 to 3 x 106 and stress ratio of R = -2 to 0.5. In all these cases the proposed model described fatigue results with small scatter. Studying this model, following knowledge was obtained:– the parameter ”stress ratio R” was a good physical characteristic– the proposed model provided a good description of the eight collections of fatigue test results by one equation only– the scatter of the results through the whole scope is only a little greater than that round the individual S/N curve– using this model while testing may reduce the number of test samples and shorten the test time– as the proposed model represents a common form of the S/N curve, it may be used for processing uniform objective fatigue life results, which may enable mutual comparison of fatigue characteristics.
Normalization and Implementation of Three Gravitational Acceleration Models
Eckman, Randy A.; Brown, Aaron J.; Adamo, Daniel R.; Gottlieb, Robert G.
2016-01-01
Unlike the uniform density spherical shell approximations of Newton, the consequence of spaceflight in the real universe is that gravitational fields are sensitive to the asphericity of their generating central bodies. The gravitational potential of an aspherical central body is typically resolved using spherical harmonic approximations. However, attempting to directly calculate the spherical harmonic approximations results in at least two singularities that must be removed to generalize the method and solve for any possible orbit, including polar orbits. Samuel Pines, Bill Lear, and Robert Gottlieb developed three unique algorithms to eliminate these singularities. This paper documents the methodical normalization of two of the three known formulations for singularity-free gravitational acceleration (namely, the Lear and Gottlieb algorithms) and formulates a general method for defining normalization parameters used to generate normalized Legendre polynomials and Associated Legendre Functions (ALFs) for any algorithm. A treatment of the conventional formulation of the gravitational potential and acceleration is also provided, in addition to a brief overview of the philosophical differences between the three known singularity-free algorithms.
Towards Integrated Design and Modeling of High Field Accelerator Magnets
Caspi, S.; Ferracin, P.
2006-06-01
The next generation of superconducting accelerator magnets will most likely use a brittle conductor (such as Nb{sub 3}Sn), generate fields around 18 T, handle forces that are 3-4 times higher than in the present LHC dipoles, and store energy that starts to make accelerator magnets look like fusion magnets. To meet the challenge and reduce the complexity, magnet design will have to be more innovative and better integrated. The recent design of several high field superconducting magnets have now benefited from the integration between CAD (e.g. ProE), magnetic analysis tools (e.g. TOSCA) and structural analysis tools (e.g. ANSYS). Not only it is now possible to address complex issues such as stress in magnet ends, but the analysis can be better detailed an extended into new areas previously too difficult to address. Integrated thermal, electrical and structural analysis can be followed from assembly and cool-down through excitation and quench propagation. In this paper we report on the integrated design approach, discuss analysis results and point out areas of future interest.
Modeling Extreme Solar Energetic Particle Acceleration with Self-Consistent Wave Generation
Arthur, A. D.; le Roux, J. A.
2015-12-01
Observations of extreme solar energetic particle (SEP) events associated with coronal mass ejection driven shocks have detected particle energies up to a few GeV at 1 AU within the first ~10 minutes to 1 hour of shock acceleration. Whether or not acceleration by a single shock is sufficient in these events or if some combination of multiple shocks or solar flares is required is currently not well understood. Furthermore, the observed onset times of the extreme SEP events place the shock in the corona when the particles escape upstream. We have updated our focused transport theory model that has successfully been applied to the termination shock and traveling interplanetary shocks in the past to investigate extreme SEP acceleration in the solar corona. This model solves the time-dependent Focused Transport Equation including particle preheating due to the cross shock electric field and the divergence, adiabatic compression, and acceleration of the solar wind flow. Diffusive shock acceleration of SEPs is included via the first-order Fermi mechanism for parallel shocks. To investigate the effects of the solar corona on the acceleration of SEPs, we have included an empirical model for the plasma number density, temperature, and velocity. The shock acceleration process becomes highly time-dependent due to the rapid variation of these coronal properties with heliocentric distance. Additionally, particle interaction with MHD wave turbulence is modeled in terms of gyroresonant interactions with parallel propagating Alfven waves. However, previous modeling efforts suggest that the background amplitude of the solar wind turbulence is not sufficient to accelerate SEPs to extreme energies over the short time scales observed. To account for this, we have included the transport and self-consistent amplification of MHD waves by the SEPs through wave-particle gyroresonance. We will present the results of this extended model for a single fast quasi-parallel CME driven shock in the
Accelerated Aging of Intervertebral Discs in a Mouse Model of Progeria
Vo, Nam; Seo, Hyoung-Yeon; Robinson, Andria; Sowa, Gwendolyn; Bentley, Douglas; Taylor, Lauren; Studer, Rebecca; Usas, Arvydas; Huard, Johnny; Alber, Sean; Watkins, Simon C.; Lee, Joon; Coehlo, Paulo; Wang, Dong; Loppini, Mattia; Robbins, Paul D.; Niedernhofer, Laura J.; Kang, James
2012-01-01
Intervertebral disc degeneration (IDD) is a common and debilitating disorder that results in reduced flexibility of the spine, pain, and reduced mobility. Risk factors for IDD include age, genetic predisposition, injury, and other environmental factors such as smoking. Loss of proteoglycans (PGs) contributes to IDD with advancing age. Currently there is a lack of a model for rapid investigation of disc aging and evaluation of therapeutic interventions. Here we examined progression of disc aging in a murine model of a human progeroid syndrome caused by deficiency of the DNA repair endonuclease, ERCC1–XPF (Ercc1−/Δ mice). The ERCC1-deficient mice showed loss of disc height and degenerative structural changes in their vertebral bodies similar to those reported for old rodents. Compared to their wild-type littermates, Ercc1−/Δ mice also exhibit other age-related IDD characteristics, including premature loss of disc PG, reduced matrix PG synthesis, and enhanced apoptosis and cell senescence. Finally, the onset of age-associated disc pathologies was further accelerated in Ercc1−/Δ mice following chronic treatment with the chemotherapeutic agent mechlorethamine. These results demonstrate that Ercc1−/Δ mice represent an accurate and rapid model of disc aging and provide novel evidence that DNA damage negatively impacts PG synthesis. PMID:20973062
Modeling Pulse Characteristics in Xenon with NEST
Mock, Jeremy; Kazkaz, Kareem; Szydagis, Matthew; Tripathi, Mani; Uvarov, Sergey; Woods, Michael; Walsh, Nicholas
2013-01-01
A comprehensive model for describing the characteristics of pulsed signals, generated by particle interactions in xenon detectors, is presented. An emphasis is laid on two-phase time projection chambers, but the models presented are also applicable to single phase detectors. In order to simulate the pulse shape due to primary scintillation light, effects such as the ratio of singlet and triplet dimer state populations, as well as their corresponding decay times, and the recombination time are incorporated into the model. In a two phase time projection chamber, when simulating the pulse caused by electroluminescence light, parameters such as ionization electron mean free path in gas, the drift velocity, singlet and triplet decay times, diffusion constants, and the electron trapping time, have been implemented. This modeling has been incorporated into a complete software package, which realistically simulates the expected pulse shapes for these types of detectors.
A Stochastic Acceleration Model of Radio Emission from Pulsar Wind Nebulae
Tanaka, S.; Asano, K.
2016-06-01
The broadband emission of Pulsar Wind Nebulae (PWNe) is well described by non-thermal emissions from accelerated electrons and positrons. However, the difference of spectral indices at radio and X-rays are not reproduced by the standard shock particle acceleration and cooling processes, and then, for example, the broken power-law spectrum for the particle energy distribution at the injection has been groundlessly adopted. Here, we propose a possible resolution for the particle distribution; the radio emitting particles are not accelerated at the pulsar wind termination shock but are stochastically accelerated by turbulence inside the PWNe. The turbulence may be induced by the interaction of the pulsar wind with the supernova ejecta. We upgrade our one-zone spectral evolution model including the stochastic acceleration and apply it to the Crab Nebula. We consider both continuous and impulsive injections of particles to the stochastic acceleration process. The radio emission in the Crab Nebula is reproduced by our stochastic acceleration model. The required forms of the momentum diffusion coefficient will be discussed.
Considering Late-Time Acceleration in Some Cosmological Models
S. Davood Sadatian
2013-01-01
Full Text Available We study two cosmological models: a nonminimally coupled scalar field on brane world model and a minimally coupled scalar field on Lorentz invariance violation model. We compare some cosmological results in these scenarios. Also, we consider some types of Rip singularity solution in both models.
Nomura, M.; Shimada, T.; Tamura, F.; Yamamoto, M.; Hara, K.; Hasegawa, K.; Ohmori, C.; Takata, K.; Toda, M.; Yoshii, M.; Schnase, A.
2014-06-01
We employ Magnetic Alloy (MA) core loaded RF cavities for the J-PARC synchrotrons to achieve a high field gradient. The MA core has a laminated structure of 18 μm thick ribbon layers. We have been developing high shunt impedance MA cores to prepare for an increase of beam power. At low frequencies, it is well known that the eddy current loss in the ribbon is proportional to the square of the ribbon thickness. The MA core shunt impedance can be increased by using thinner ribbons. On the other hand, at high frequencies, the MA core magnetic characteristics are largely different from low frequencies. Using thinner ribbons might be effective to increase the MA core shunt impedance in the accelerating frequency region of the J-PARC synchrotrons. We reviewed the theoretical calculations of the ribbon thickness dependence of the MA core magnetic characteristics and we derived the ribbon thickness dependence from measured data. The measured data show that the MA core shunt impedance is inversely proportional to the ribbon thickness in the accelerating frequency region of the J-PARC synchrotrons, which is consistent with our calculations.
Numerical design and model measurements for a 1.3 GHz microtron accelerating cavity
Kleeven, W. J. G. M.; Theeuwen, M. E. H. J.; Knoben, M. H. M.; Moerdijk, A. J.; Botman, J. I. M.; van der Heide, J. A.; Timmermans, C. J.; Hagedoorn, H. L.
1992-05-01
As part of the free electron laser project TEUFEL, a 25 MeV racetrack microtron is under construction at the Eindhoven University. The accelerating cavity of this microtron is a standing wave on axis coupled structure. It consists of three accelerating cells and two coupling cells. Numerical field calculations for this cavity were done with the computer codes SUPERFISH, URMEL-T and MAFIA. Not only the accelerating modes but also the dangerous beam breakup modes were calculated with MAFIA. An aluminium, scale 1:1 model of the structure was made in order to measure various cavity properties. Field profiles were measured with the perturbation ball method. An equivalent LC-circuit simulation of the accelerating structure was made, which serves as a model for the interpretation of the results.
Righi, Sergio; Karaj, Evis; Felici, Giuseppe; Di Martino, Fabio
2013-01-07
The Novac7 and Liac are linear accelerators (linacs) dedicated to intraoperative radiation therapy (IORT), which produce high energy, very high dose-per-pulse electron beams. The characteristics of the accelerators heads of the Novac7 and Liac are different compared to conventional electron accelerators. The aim of this work was to investigate the specific characteristics of the Novac7 and Liac electron beams using the Monte Carlo method. The Monte Carlo code BEAMnrc has been employed to model the head and simulate the electron beams. The Monte Carlo simulation was preliminarily validated by comparing the simulated dose distributions with those measured by means of EBT radiochromic film. Then, the energy spectra, mean energy profiles, fluence profiles, photon contamination, and angular distributions were obtained from the Monte Carlo simulation. The Spencer-Attix water-to-air mass restricted collision stopping power ratios (sw,air) were also calculated. Moreover, the modifications of the percentage depth dose in water (backscatter effect) due to the presence of an attenuator plate composed of a sandwich of a 2 mm aluminum foil and a 4 mm lead foil, commonly used for breast treatments, were evaluated. The calculated sw,air values are in agreement with those tabulated in the IAEA TRS-398 dosimetric code of practice within 0.2% and 0.4% at zref (reference depth in water) for the Novac7 and Liac, respectively. These differences are negligible for practical dosimetry. The attenuator plate is sufficient to completely absorb the electron beam for each energy of the Novac7 and Liac; moreover, the shape of the dose distribution in water strongly changes with the introduction of the attenuator plate. This variation depends on the energy of the beam, and it can give rise to an increase in the maximum dose in the range of 3%-9%.
Smith, B.
2015-12-01
In 2014, eight Department of Energy (DOE) national laboratories, four academic institutions, one company, and the National Centre for Atmospheric Research combined forces in a project called Accelerated Climate Modeling for Energy (ACME) with the goal to speed Earth system model development for climate and energy. Over the planned 10-year span, the project will conduct simulations and modeling on DOE's most powerful high-performance computing systems at Oak Ridge, Argonne, and Lawrence Berkeley Leadership Compute Facilities. A key component of the ACME project is the development of an interactive test bed for the advanced Earth system model. Its execution infrastructure will accelerate model development and testing cycles. The ACME Workflow Group is leading the efforts to automate labor-intensive tasks, provide intelligent support for complex tasks and reduce duplication of effort through collaboration support. As part of this new workflow environment, we have created a diagnostic, metric, and intercomparison Python framework, called UVCMetrics, to aid in the testing-to-production execution of the ACME model. The framework exploits similarities among different diagnostics to compactly support diagnosis of new models. It presently focuses on atmosphere and land but is designed to support ocean and sea ice model components as well. This framework is built on top of the existing open-source software framework known as the Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT). Because of its flexible framework design, scientists and modelers now can generate thousands of possible diagnostic outputs. These diagnostics can compare model runs, compare model vs. observation, or simply verify a model is physically realistic. Additional diagnostics are easily integrated into the framework, and our users have already added several. Diagnostics can be generated, viewed, and manipulated from the UV-CDAT graphical user interface, Python command line scripts and programs
Characteristic Polynomials of Complex Random Matrix Models
Akemann, G
2003-01-01
We calculate the expectation value of an arbitrary product of characteristic polynomials of complex random matrices and their hermitian conjugates. Using the technique of orthogonal polynomials in the complex plane our result can be written in terms of a determinant containing these polynomials and their kernel. It generalizes the known expression for hermitian matrices and it also provides a generalization of the Christoffel formula to the complex plane. The derivation we present holds for complex matrix models with a general weight function at finite-N, where N is the size of the matrix. We give some explicit examples at finite-N for specific weight functions. The characteristic polynomials in the large-N limit at weak and strong non-hermiticity follow easily and they are universal in the weak limit. We also comment on the issue of the BMN large-N limit.
Shear creep characteristics and constitutive model of limestone
Yu Mei; Mao Xianbiao; Hu Xinyu
2016-01-01
The characters of limestone in weak interlayer of a high rocky slope in Xuzhou, China, are studied by shear static test and shear creep test. The results show that limestone specimens have attenuation creep properties and constant rate creep properties, almost have no accelerated creep properties. The exponen-tial type empirical formula is selected to fit creep grading curves by polynomial regression analysis method, and the square sums of the fitting results residual are in the order of 10-7. Then grade creep curves at every shear loads are set up. Combining creep rate-time curve, the creep properties of limestone are analyzed. As the physical meaning of component model is clearer, the Poytin–Thomson model is set up. Through the least square method, the optimal parameters of Poytin–Thomson model are obtained, and the sums of squared residuals belong to 10-3 order of magnitude, which can meet the accuracy requirements of engineering calculation. So the Poytin–Thomson model can reflect the shear creep char-acteristics of limestone very well.
Trait Characteristics of Diffusion Model Parameters
Anna-Lena Schubert
2016-07-01
Full Text Available Cognitive modeling of response time distributions has seen a huge rise in popularity in individual differences research. In particular, several studies have shown that individual differences in the drift rate parameter of the diffusion model, which reflects the speed of information uptake, are substantially related to individual differences in intelligence. However, if diffusion model parameters are to reflect trait-like properties of cognitive processes, they have to qualify as trait-like variables themselves, i.e., they have to be stable across time and consistent over different situations. To assess their trait characteristics, we conducted a latent state-trait analysis of diffusion model parameters estimated from three response time tasks that 114 participants completed at two laboratory sessions eight months apart. Drift rate, boundary separation, and non-decision time parameters showed a great temporal stability over a period of eight months. However, the coefficients of consistency and reliability were only low to moderate and highest for drift rate parameters. These results show that the consistent variance of diffusion model parameters across tasks can be regarded as temporally stable ability parameters. Moreover, they illustrate the need for using broader batteries of response time tasks in future studies on the relationship between diffusion model parameters and intelligence.
The stability analysis of the full velocity and acceleration velocity model
Xiaomei, Zhao; Ziyou, Gao
2007-03-01
The stability analysis is one of the important problems in the traffic flow theory, since the congestion phenomena can be regarded as the instability and the phase transition of a dynamical system. Theoretically, we analyze the stable conditions of the full velocity and acceleration difference model (FVADM), which is proposed by introducing the acceleration difference term based on the previous car-following models (the optimal velocity model and the full velocity difference model, OVM and FVDM). By numerical simulations, it is found that when the traffic flow is unstable, the traffic jam in the FVADM is weaker than that in the FVDM. Also it is observed that the spreading speed of the jam is slower in the FVADM than that in the FVDM and the fluctuations of vehicles in the FVADM are smaller than those in the FVDM. Therefore, the acceleration difference term has strong effects on traffic dynamics and plays an important role in stabilizing the traffic flow.
Accelerator simulation and theoretical modelling of radiation effects (SMoRE)
2018-01-01
This publication summarizes the findings and conclusions of the IAEA coordinated research project (CRP) on accelerator simulation and theoretical modelling of radiation effects, aimed at supporting Member States in the development of advanced radiation-resistant structural materials for implementation in innovative nuclear systems. This aim can be achieved through enhancement of both experimental neutron-emulation capabilities of ion accelerators and improvement of the predictive efficiency of theoretical models and computer codes. This dual approach is challenging but necessary, because outputs of accelerator simulation experiments need adequate theoretical interpretation, and theoretical models and codes need high dose experimental data for their verification. Both ion irradiation investigations and computer modelling have been the specific subjects of the CRP, and the results of these studies are presented in this publication which also includes state-ofthe- art reviews of four major aspects of the project...
Hossain, Murshed
2014-07-08
The purpose of this study is to characterize and understand the long-term behavior of the output from megavoltage radiotherapy linear accelerators. Output trends of nine beams from three linear accelerators over a period of more than three years are reported and analyzed. Output, taken during daily warm-up, forms the basis of this study. The output is measured using devices having ion chambers. These are not calibrated by accredited dosimetry laboratory, but are baseline-compared against monthly output which is measured using calibrated ion chambers. We consider the output from the daily check devices as it is, and sometimes normalized it by the actual output measured during the monthly calibration of the linacs. The data show noisy quasi-periodic behavior. The output variation, if normalized by monthly measured "real' output, is bounded between ± 3%. Beams of different energies from the same linac are correlated with a correlation coefficient as high as 0.97, for one particular linac, and as low as 0.44 for another. These maximum and minimum correlations drop to 0.78 and 0.25 when daily output is normalized by the monthly measurements. These results suggest that the origin of these correlations is both the linacs and the daily output check devices. Beams from different linacs, independent of their energies, have lower correlation coefficient, with a maximum of about 0.50 and a minimum of almost zero. The maximum correlation drops to almost zero if the output is normalized by the monthly measured output. Some scatter plots of pairs of beam output from the same linac show band-like structures. These structures are blurred when the output is normalized by the monthly calibrated output. Fourier decomposition of the quasi-periodic output is consistent with a 1/f power law. The output variation appears to come from a distorted normal distribution with a mean of slightly greater than unity. The quasi-periodic behavior is manifested in the seasonally averaged output
Accelerating Monte Carlo Markov chains with proxy and error models
Josset, Laureline; Demyanov, Vasily; Elsheikh, Ahmed H.; Lunati, Ivan
2015-12-01
In groundwater modeling, Monte Carlo Markov Chain (MCMC) simulations are often used to calibrate aquifer parameters and propagate the uncertainty to the quantity of interest (e.g., pollutant concentration). However, this approach requires a large number of flow simulations and incurs high computational cost, which prevents a systematic evaluation of the uncertainty in the presence of complex physical processes. To avoid this computational bottleneck, we propose to use an approximate model (proxy) to predict the response of the exact model. Here, we use a proxy that entails a very simplified description of the physics with respect to the detailed physics described by the "exact" model. The error model accounts for the simplification of the physical process; and it is trained on a learning set of realizations, for which both the proxy and exact responses are computed. First, the key features of the set of curves are extracted using functional principal component analysis; then, a regression model is built to characterize the relationship between the curves. The performance of the proposed approach is evaluated on the Imperial College Fault model. We show that the joint use of the proxy and the error model to infer the model parameters in a two-stage MCMC set-up allows longer chains at a comparable computational cost. Unnecessary evaluations of the exact responses are avoided through a preliminary evaluation of the proposal made on the basis of the corrected proxy response. The error model trained on the learning set is crucial to provide a sufficiently accurate prediction of the exact response and guide the chains to the low misfit regions. The proposed methodology can be extended to multiple-chain algorithms or other Bayesian inference methods. Moreover, FPCA is not limited to the specific presented application and offers a general framework to build error models.
Time and Space Dependent Stochastic Acceleration Model for the Fermi Bubbles
Sasaki, K; Terasawa, T
2015-01-01
Fermi-LAT reveals two huge gamma-ray bubbles existing in the Galactic Center, called 'Fermi Bubbles'. The existence of two microwave bubbles at the same region are also reported by the observation by WMAP, dubbed 'WMAP haze'. In order to explain these components, It has been argued that the gamma-rays arise from Inverse-Compton scattering of relativistic electrons accelerated by plasma turbulence, and the microwaves are radiated by synchrotron radiation. But no previous research reproduces both the Fermi Bubbles and WMAP haze under typical magnetic fields in the galaxy. We assume that shocks present in the bubbles and the efficiency of the acceleration by plasma turbulence, 'stochastic acceleration', changes with the distance from the shock front. The distance from the shock front increases with time, accordingly the efficiency of the acceleration changes with time. We also consider the time development of the electrons escape from the turbulence by diffusive loss. Our model succeed to reproduce both the obse...
An adaptive attitude algorithm based on a current statistical model for maneuvering acceleration
Menglong Wang
2017-02-01
Full Text Available A current statistical model for maneuvering acceleration using an adaptive extended Kalman filter (CS-MAEKF algorithm is proposed to solve problems existing in conventional extended Kalman filters such as large estimation error and divergent tendencies in the presence of continuous maneuvering acceleration. A membership function is introduced in this algorithm to adaptively modify the upper and lower limits of loitering vehicles’ maneuvering acceleration and for real-time adjustment of maneuvering acceleration variance. This allows the algorithm to have superior static and dynamic performance for loitering vehicles undergoing different maneuvers. Digital simulations and dynamic flight testing show that the yaw angle accuracy of the algorithm is 30% better than conventional algorithms, and pitch and roll angle calculation precision is improved by 60%. The mean square deviation of heading and attitude angle error during dynamic flight is less than 3.05°. Experimental results show that CS-MAEKF meets the application requirements of miniature loitering vehicles.
Particle-In-Cell Modeling of Plasma-Based Accelerators in Two and Three Dimensions
Hemker, Roy G
2015-01-01
In this dissertation, a fully object-oriented, fully relativistic, multi-dimensional Particle-In-Cell code was developed and applied to answer key questions in plasma-based accelerator research. The simulations increase the understanding of the processes in laser plasma and beam-plasma interaction, allow for comparison with experiments, and motivate the development of theoretical models. The simulations support the idea that the injection of electrons in a plasma wave by using a transversely propagating laser pulse is possible. The beam parameters of the injected electrons found in the simulations compare reasonably with beams produced by conventional methods and therefore laser injection is an interesting concept for future plasma-based accelerators. Simulations of the optical guiding of a laser wakefield driver in a parabolic plasma channel support the idea that electrons can be accelerated over distances much longer than the Rayleigh length in a channel. Simulations of plasma wakefield acceleration in the ...
Reproductive characteristics of Awassi ewes under Cornell alternate month accelerated lambing system
Sabri Gül
2010-04-01
Full Text Available We investigated the reproductive responses of Awassi ewes under Cornell alternate month accelerated lambing (CAMAL system. Ewes were randomly allocated to two experimental groups. The first group (control group consists of 20 ewes exposed to rams in September under conventional management system while the second group (CAMAL were divided into four sub-flocks contain 20 head of ewes each one were exposed to rams to obtain three lambing in two years with different breeding and lambing months. In CAMAL ewes, oestrus was synchronized using intra-vaginal sponges with progesterone and PMSG administration. Results revealed that within CAMAL group, the percentage of animals in heat, onset of oestrus, litter size, birth weight and weaning weight were affected by mating months. September and November were the most appropriate months for oestrus ratio (97.5 % and litter size (1.18 and 0.98, respectively. Lambs of control group were heavier at birth and weaning than those of CAMAL group. On the other hand lamb yield was not affected statistically by the CAMAL administration.
Attalla Ehab
2010-01-01
Full Text Available Dosimetric properties of virtual wedge (VW and physical wedge (PW in 6- and 10-MV photon beams from a Siemens ONCOR linear accelerator, including wedge factors, depth doses, dose profiles, peripheral doses, are compared. While there is a great difference in absolute values of wedge factors, VW factors (VWFs and PW factors (PWFs have a similar trend as a function of field size. PWFs have stronger depth dependence than VWF due to beam hardening in PW fields. VW dose profiles in the wedge direction, in general, match very well with those of PW, except in the toe area of large wedge angles with large field sizes. Dose profiles in the nonwedge direction show a significant reduction in PW fields due to off-axis beam softening and oblique filtration. PW fields have significantly higher peripheral doses than open and VW fields. VW fields have similar surface doses as the open fields, while PW fields have lower surface doses. Surface doses for both VW and PW increase with field size and slightly with wedge angle. For VW fields with wedge angles 45° and less, the initial gap up to 3 cm is dosimetrically acceptable when compared to dose profiles of PW. VW fields in general use less monitor units than PW fields.
Kinetic Modeling of Next-Generation High-Energy, High-Intensity Laser-Ion Accelerators
Albright, Brian James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Yin, Lin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stark, David James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2017-02-06
One of the long-standing problems in the community is the question of how we can model “next-generation” laser-ion acceleration in a computationally tractable way. A new particle tracking capability in the LANL VPIC kinetic plasma modeling code has enabled us to solve this long-standing problem
Lorenz, HW; Nusse, HE
Goodwin's nonlinear accelerator model with periodic investment outlays is reconsidered and used as an economic example of the emergence of complex motion in nonlinear dynamical systems. In addition to chaotic attractors, the model can possess coexisting attracting periodic orbits or simple
Tessera terrain: Characteristics and models of origin
Bindschadler, D. L.; Head, James W.
1989-01-01
Tessera terrain consists of complexly deformed regions characterized by sets of ridges and valleys that intersect at angles ranging from orthogonal to oblique, and were first viewed in Venera 15/16 SAR data. Tesserae cover more area (approx. 15 percent of the area north of 30 deg N) than any of the other tectonic units mapped from the Venera data and are strongly concentrated in the region between longitudes 0 deg E and 150 deg E. Tessera terrain is concentrated between a proposed center of crustal extension and divergence in Aphrodite and a region of intense deformation, crustal convergence, and orogenesis in western Ishtar Terra. Thus, the tectonic processes responsible for tesserae are an important part of Venus tectonics. As part of an effort to understand the formation and evolution of this unusual terrain type, the basic characteristics of the tesserae were compared to the predictions made by a number of tectonic models. The basic characteristics of tessera terrain are described and the models and some of their basic predictions are briefly discussed.
New, More Authentic Model for AIDS Will Accelerate Studies | Poster
By Frank Blanchard, Staff Writer, and Jeff Lifson, Guest Writer Researchers are working to develop a more authentic animal model of human immunodeficiency virus (HIV) infection and AIDS that is expected to speed up studies of experimental treatments and vaccines.
Tian, Zhen; Folkerts, Michael; Shi, Feng; Jiang, Steve B; Jia, Xun
2015-01-01
Monte Carlo (MC) simulation is considered as the most accurate method for radiation dose calculations. Accuracy of a source model for a linear accelerator is critical for the overall dose calculation accuracy. In this paper, we presented an analytical source model that we recently developed for GPU-based MC dose calculations. A key concept called phase-space-ring (PSR) was proposed. It contained a group of particles that are of the same type and close in energy and radial distance to the center of the phase-space plane. The model parameterized probability densities of particle location, direction and energy for each primary photon PSR, scattered photon PSR and electron PSR. For a primary photon PSRs, the particle direction is assumed to be from the beam spot. A finite spot size is modeled with a 2D Gaussian distribution. For a scattered photon PSR, multiple Gaussian components were used to model the particle direction. The direction distribution of an electron PSRs was also modeled as a 2D Gaussian distributi...
Eusebi, Anna Laura; Bellezze, Tiziano; Chiappini, Gianluca; Sasso, Marco; Battistoni, Paolo
2017-06-15
The paper deals with the evaluation of the effect of on/off switching of diffuser membranes, in the intermittent aeration process of the urban wastewater treatments. Accelerated tests were done using two types of commercial EPDM diffusers, which were submitted to several consecutive cycles up to the simulation of more than 8 years of real working conditions. The effect of this switching on the mechanical characteristics of the membranes was evaluated in terms of pressure increment of the air operating at different flow rates (2, 3.5 and 6 m(3)/h/diff): during accelerated tests, such increment ranged from 2% to 18%. The intermittent phases emphasized the loss both of the original mechanical proprieties of the diffusers and of the initial pore shapes. The main cause of pressure increment was attributed to the fouling of the internal channels of the pores. Further analyses performed by scanning electron microscopy and by mechanical tests on EPDM membrane, using a traditional tensile test and a non destructive optical method, from which the Young's Modulus was obtained, supported previous conclusions. Any changes in terms of oxygen transfer parameters (KLa and SOTE%) were specifically founded by causing to the repeated on/off switching. Copyright © 2017. Published by Elsevier Ltd.
Subsurface Gas Flow and Ice Grain Acceleration within Enceladus and Europa Fissures: 2D DSMC Models
Tucker, O. J.; Combi, M. R.; Tenishev, V.
2014-12-01
The ejection of material from geysers is a ubiquitous occurrence on outer solar system bodies. Water vapor plumes have been observed emanating from the southern hemispheres of Enceladus and Europa (Hansen et al. 2011, Roth et al. 2014), and N2plumes carrying ice and ark particles on Triton (Soderblom et al. 2009). The gas and ice grain distributions in the Enceladus plume depend on the subsurface gas properties and the geometry of the fissures e.g., (Schmidt et al. 2008, Ingersoll et al. 2010). Of course the fissures can have complex geometries due to tidal stresses, melting, freezing etc., but directly sampled and inferred gas and grain properties for the plume (source rate, bulk velocity, terminal grain velocity) can be used to provide a basis to constrain characteristic dimensions of vent width and depth. We used a 2-dimensional Direct Simulation Monte Carlo (DSMC) technique to model venting from both axi-symmetric canyons with widths ~2 km and narrow jets with widths ~15-40 m. For all of our vent geometries, considered the water vapor source rates (1027 - 1028 s-1) and bulk gas velocities (~330 - 670 m/s) obtained at the surface were consistent with inferred values obtained by fits of the data for the plume densities (1026 - 1028 s-1, 250 - 1000 m/s) respectively. However, when using the resulting DSMC gas distribution for the canyon geometries to integrate the trajectories of ice grains we found it insufficient to accelerate submicron ice grains to Enceladus' escape speed. On the other hand, the gas distributions in the jet like vents accelerated grains > 10 μm significantly above Enceladus' escape speed. It has been suggested that micron-sized grains are ejected from the vents with speeds comparable to the Enceladus escape speed. Here we report on these results including comparisons to results obtained from 1D models as well as discuss the implications of our plume model results. We also show preliminary results for similar considerations applied to Europa
Three-dimensional electromagnetic model of the pulsed-power Z-pinch accelerator
Rose, D. V.; Welch, D. R.; Madrid, E. A.; Miller, C. L.; Clark, R. E.; Stygar, W. A.; Savage, M. E.; Rochau, G. A.; Bailey, J. E.; Nash, T. J.; Sceiford, M. E.; Struve, K. W.; Corcoran, P. A.; Whitney, B. A.
2010-01-01
A three-dimensional, fully electromagnetic model of the principal pulsed-power components of the 26-MA ZR accelerator [D. H. McDaniel , in Proceedings of the 5th International Conference on Dense Z-Pinches (AIP, New York, 2002), p. 23] has been developed. This large-scale simulation model tracks the evolution of electromagnetic waves through the accelerator’s intermediate-storage capacitors, laser-triggered gas switches, pulse-forming lines, water switches, triplate transmission lines, and water convolute to the vacuum insulator stack. The insulator-stack electrodes are coupled to a transmission-line circuit model of the four-level magnetically insulated vacuum-transmission-line section and double-post-hole convolute. The vacuum-section circuit model is terminated by a one-dimensional self-consistent dynamic model of an imploding z-pinch load. The simulation results are compared with electrical measurements made throughout the ZR accelerator, and are in good agreement with the data, especially for times until peak load power. This modeling effort demonstrates that 3D electromagnetic models of large-scale, multiple-module, pulsed-power accelerators are now computationally tractable. This, in turn, presents new opportunities for simulating the operation of existing pulsed-power systems used in a variety of high-energy-density-physics and radiographic applications, as well as even higher-power next-generation accelerators before they are constructed.
GPU accelerated numerical simulations of viscoelastic phase separation model.
Yang, Keda; Su, Jiaye; Guo, Hongxia
2012-07-05
We introduce a complete implementation of viscoelastic model for numerical simulations of the phase separation kinetics in dynamic asymmetry systems such as polymer blends and polymer solutions on a graphics processing unit (GPU) by CUDA language and discuss algorithms and optimizations in details. From studies of a polymer solution, we show that the GPU-based implementation can predict correctly the accepted results and provide about 190 times speedup over a single central processing unit (CPU). Further accuracy analysis demonstrates that both the single and the double precision calculations on the GPU are sufficient to produce high-quality results in numerical simulations of viscoelastic model. Therefore, the GPU-based viscoelastic model is very promising for studying many phase separation processes of experimental and theoretical interests that often take place on the large length and time scales and are not easily addressed by a conventional implementation running on a single CPU.
Heterogeneity and aggregation in a financial accelerator model
Assenza, T.; Delli Gatti, D.; Gallegati, M.
2007-01-01
In this paper we present a macroeconomic model in which changes in the variance (and higher moments of the distribution) of firm's financial conditions - i.e. "distributive shocks" - are bound to play a crucial role in the determination of output fluctuations. Firms differ by degree of financial rob
Super-acceleration in non-minimal derivative coupling model
Sadjadi, H Mohseni
2010-01-01
A scalar field model with non-minimal derivative coupling to gravity is considered. It is shown that although in the absence of matter and potential the phantom divide line crossing is forbidden, but for the power law potential and in the presence of matter this crossing is, in principle, possible.
DiVinE-CUDA - A Tool for GPU Accelerated LTL Model Checking
Jiří Barnat
2009-12-01
Full Text Available In this paper we present a tool that performs CUDA accelerated LTL Model Checking. The tool exploits parallel algorithm MAP adjusted to the NVIDIA CUDA architecture in order to efficiently detect the presence of accepting cycles in a directed graph. Accepting cycle detection is the core algorithmic procedure in automata-based LTL Model Checking. We demonstrate that the tool outperforms non-accelerated version of the algorithm and we discuss where the limits of the tool are and what we intend to do in the future to avoid them.
Effects of energetic electrons on ion acceleration in a quasi-static model
Bahache, Abdelkadrer; Bennaceur-Doumaz, Djamila; Djebli, Mourad
2017-08-01
Based on the Passoni-Lontano model [M. Lontano and M. Passoni, Phys. Plasmas 13(4), 042102 (2006)], the expansion of an intense laser produced plasma into vacuum is analyzed, assuming that hot and energetic electrons responsible for ion acceleration, in the framework of a TNSA mechanism, are nonthermal and modelled by the Cairns distribution function. Due to the presence of energetic nonthermal electron population, the electric potential, electrical field, ion maximum energy, and ion spectrum energy are enhanced during the ion acceleration process.
In Defense of an Accelerating Universe: Model Insensitivity of the Hubble Diagram
Ringermacher, H I
2016-01-01
Nielsen, Guffanti and Sarkar, in their recent Nature article, present a detailed argument that the evidence for cosmic acceleraton is marginal and that a coasting universe model, namely that of the "Milne Universe", fits the same SNe Ia data set in a Hubble diagram (distance modulus vs. redshift) nearly as well. However, we find that when the SNe data, the LCDM model and Milne model are plotted as scale factor vs. linear cosmological time in a model-independent fashion the two resulting curves separate significantly above the noise making it exceptionally clear that the universe is accelerating and the Milne model cannot fit the time-data. In this plot, the Milne model generates a straight line, while LCDM continues to show an excellent fit to acceleration. The separation of these two models on this type of plot demonstrates the efficacy of this new plot procedure.
Test-particle acceleration in a hierarchical three-dimensional turbulence model
Dalena, S.; Rappazzo, A. F.; Matthaeus, W. H. [Bartol Research Institute, Department of Physics and Astronomy, University of Delaware, DE 19716 (United States); Dmitruk, P. [Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires (Argentina); Greco, A., E-mail: serena.dalena@fis.unical.it [Dipartimento di Fisica, Università della Calabria, I-87036 Cosenza (Italy)
2014-03-10
The acceleration of charged particles is relevant to the solar corona over a broad range of scales and energies. High-energy particles are usually detected in concomitance with large energy release events like solar eruptions and flares. Nevertheless, acceleration can occur at smaller scales, characterized by dynamical activity near current sheets. To gain insight into the complex scenario of coronal charged particle acceleration, we investigate the properties of acceleration with a test-particle approach using three-dimensional magnetohydrodynamic (MHD) models. These are obtained from direct solutions of the reduced MHD equations, well suited for a plasma embedded in a strong axial magnetic field, relevant to the inner heliosphere. A multi-box, multiscale technique is used to solve the equations of motion for protons. This method allows us to resolve an extended range of scales present in the system, namely, from the ion inertial scale of the order of a meter up to macroscopic scales of the order of 10 km (1/100th of the outer scale of the system). This new technique is useful to identify the mechanisms that, acting at different scales, are responsible for acceleration to high energies of a small fraction of the particles in the coronal plasma. We report results that describe acceleration at different stages over a broad range of time, length, and energy scales.
Modeling of cyclists acceleration behavior using naturalistic data
Luo, Ding
2014-01-01
Over the past few years, many cities have witnessed the increasing popularity of cycling, especially among ordinary commuters. Accordingly, there has also been a fast growing demand for the knowledge of cycling performance as well as cyclist behavior, which can be valuable for both traffic planners and policy makers when it comes to the bicycle-related issues. The aim of this study, hence, is to investigate the cycling performance in detail and to further develop proper models which can be im...
Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer
2015-12-01
receive salvage therapy that results in only a few weeks of disease stability. We have proposed to employ a team science , systems biology based approach...Pertea, G., Mortazavi, A., Kwan, G., van Baren, M.J., Salzberg, S.L., Wold , B.J., and Pachter, L. 2010. Transcript assembly and quantification by...tumor xenografts (PDTX) have been widely used in predictive biomarker development and pathway modeling in cancer research. However, it has not been
Accelerating thermal deposition modeling at terahertz frequencies using GPUs
Doroski, Michael; Knight, Michael; Payne, Jason; Grundt, Jessica E.; Ibey, Bennett L.; Thomas, Robert; Roach, William P.; Wilmink, Gerald J.
2011-03-01
Finite-difference time-domain (FDTD) methods are widely used to model the propagation of electromagnetic radiation in biological tissues. High-performance central processing units (CPUs) can execute FDTD simulations for complex problems using 3-D geometries and heterogeneous tissue material properties. However, when FDTD simulations are employed at terahertz (THz) frequencies excessively long processing times are required to account for finer resolution voxels and larger computational modeling domains. In this study, we developed and tested the performance of 2-D and 3-D FDTD thermal propagation code executed on a graphics processing unit (GPU) device, which was coded using an extension of the C language referred to as CUDA. In order to examine the speedup provided by GPUs, we compared the performance (speed, accuracy) for simulations executed on a GPU (Tesla C2050), a high-performance CPU (Intel Xeon 5504), and supercomputer. Simulations were conducted to model the propagation and thermal deposition of THz radiation in biological materials for several in vitro and in vivo THz exposure scenarios. For both the 2-D and 3-D in vitro simulations, we found that the GPU performed 100 times faster than runs executed on a CPU, and maintained comparable accuracy to that provided by the supercomputer. For the in vivo tissue damage studies, we found that the GPU executed simulations 87x times faster than the CPU. Interestingly, for all exposure duration tested, the CPU, GPU, and supercomputer provided comparable predictions for tissue damage thresholds (ED50). Overall, these results suggest that GPUs can provide performance comparable to a supercomputer and at speeds significantly faster than those possible with a CPU. Therefore, GPUs are an affordable tool for conducting accurate and fast simulations for computationally intensive modeling problems.
T. Kerh
2012-01-01
Full Text Available It may not be possible to collect adequate records of strong ground motions in a short period of time; hence microtremor survey is frequently conducted to reveal the stratum structure and earthquake characteristics at a specified construction site. This paper is therefore aimed at developing a neural network model, based on available microtremor measurement and on-site soil boring test data, for predicting peak ground acceleration at a site, in a science park of Taiwan. The four key parameters used as inputs for the model are soil values of the standard penetration test, the medium grain size, the safety factor against liquefaction, and the distance between soil depth and measuring station. The results show that a neural network model with four neurons in the hidden layer can achieve better performance than other models presently available. Also, a weight-based neural network model is developed to provide reliable prediction of peak ground acceleration at an unmeasured site based on data at three nearby measuring stations. The method employed in this paper provides a new way to treat this type of seismic-related problem, and it may be applicable to other areas of interest around the world.
Modelling of the North Atlantic eddy characteristics
Ushakov, Konstantin; Ibrayev, Rashit
2017-04-01
We investigate eddy characteristics of the Atlantic basin circulation and their impact on the ocean heat transport. A 15-year-long numerical experiment is performed with the global 3-dimensional z-coordinate INMIO ocean general circulation model of 0.1 deg., 49 levels resolution in conditions of the CORE-II protocol. The model is tuned to maximal intensity of eddies production by using only biharmonic filters instead of lateral viscous and diffusive terms in the model equations. Comparison with viscous and coarse-resolution simulations shows the increase of explicitly resolved heat transfer fraction and absolute values. Vertical turbulent mixing is parameterized by the Munk-Anderson scheme including convective adjustment. The sea ice is described by a simple thermodynamic submodel. The eddying velocity and temperature field components are defined as anomalies relative to the 3-month sliding mean. The regional distributions of hydrological parameters, eddy kinetic energy, heat convergence, meridional heat transport (MHT) and Atlantic meridional overturning circulation (AMOC) streamfunction, and their temporal variability are analyzed. In some parts of the basin the simulated eddy heat transport is opposite to the mean flow transport and may change direction with depth. The MHT intensity is slightly below observationally based assessments with notable influence of the East Greenland current simulation bias. The work is supported by the Russian Science Foundation (project N 14-27-00126) and performed in the Institute of Numerical Mathematics, Russian Academy of Sciences.
Neutronic characteristics of coupled moderator proposed in integrated model
Teshigawara, Makoto; Meigo, Shin-ichiro; Sakata, Hideaki; Kai, Tetsuya; Harada, Masahide; Ikeda, Yujiro; Watanabe, Noboru [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment
2001-05-01
A pulsed spallation source for the materials science and the life science is currently developing for its construction in the High Intensity Proton Accelerator Project proposed jointly by the Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK). This report presents the analytical results of the neutronic characteristics of the coupled moderator based on the analytical results obtained by using an integrated model which has established on the extensive neutronic and technical study. Total heat deposition in a hydrogen (H{sub 2}) moderator working as the main moderator was about 420 W/MW. Maximum nuclear heat density in the H{sub 2} moderator was about 1 W/cm{sup 3}/MW. Also total heat deposition in a premoderator was about 9.2 kW/MW. The heat density of the premoderator was comparable to that of the moderator vessel made of aluminum alloy. The heat density of the premoderator and the moderator vessel is about 1.2-2 times higher than that of the hydrogen moderator. The temperature from 300 K to 400 K of the premoderator did not affect on neutron intensity of the H{sub 2} moderator. This suggested an engineering advantage on the thermal and hydraulic design. 6000 or 7000 type of a aluminum alloy was considered from the viewpoint of the neutron beam transmission. The proton beams scattered by the proton beam window did not affect on the nuclear heating in the H{sub 2} moderator. The heat deposition in the H{sub 2} moderator and the neutron intensity of the H{sub 2} moderator did not depend on the proton beam profile but it did on the distance between the proton beam and the moderator. (author)
A simple model for cavity-enhanced laser-driven ion acceleration from thin foil targets
Rączka, Piotr
2012-01-01
A scenario for the laser-driven ion acceleration off a solid target is considered, where the reflected laser pulse is redirected towards the target by reflection at the inner cavity wall, thus recycling to some extent the incident laser energy. This scenario is discussed in the context of sub-wavelength foil acceleration in the radiation pressure regime, when plasma dynamics is known to be reasonably well described by the laser-sail model. A semi-analytic extension of the 1D laser-sail model is constructed, which takes into account the effect of reflections at the inner cavity wall. The effect of cavity reflections on sub-wavelength foil acceleration is then illustrated with two concrete examples of intense laser pulses of picosecond and femtosecond duration.
A Data-Driven Analytic Model for Proton Acceleration by Large-Scale Solar Coronal Shocks
Kozarev, Kamen A
2016-01-01
We have recently studied the development of an eruptive filament-driven, large-scale off-limb coronal bright front (OCBF) in the low solar corona (Kozarev et al. 2015), using remote observations from Solar Dynamics Observatory's Advanced Imaging Assembly EUV telescopes. In that study, we obtained high-temporal resolution estimates of the OCBF parameters regulating the efficiency of charged particle acceleration within the theoretical framework of diffusive shock acceleration (DSA). These parameters include the time-dependent front size, speed, and strength, as well as the upstream coronal magnetic field orientations with respect to the front's surface normal direction. Here we present an analytical particle acceleration model, specifically developed to incorporate the coronal shock/compressive front properties described above, derived from remote observations. We verify the model's performance through a grid of idealized case runs using input parameters typical for large-scale coronal shocks, and demonstrate ...
Model of Carbon Wire Heating in Accelerator Beam
Sapinski, M
2008-01-01
A heat flow equation with beam-induced heating and various cooling processes for a carbon wire passing through a particle beam is solved. Due to equation nonlinearity a numerical approach based on discretization of the wire movement is used. Heating of the wire due to the beam-induced electromagnetic field is taken into account. An estimation of the wire sublimation rate is made. The model is tested on SPS, LEP and Tevatron Main Injector data. Results are discussed and conclusions about limits of Wire Scanner operation on LHC beams are drawn.
A two-fluid model for black-hole accretion flows: particle acceleration and disc structure
Lee, Jason P.; Becker, Peter A.
2017-02-01
Hot, tenuous advection-dominated accretion flows around black holes are ideal sites for the Fermi acceleration of relativistic particles at standing shock waves in the accretion disc. Previous work has demonstrated that the shock-acceleration process can be efficient enough to power the observed, strong outflows in radio-loud active galaxies such as M87. However, the dynamical effect (back-reaction) on the flow, exerted by the pressure of the relativistic particles, has not been previously considered, and this effect can have a significant influence on the disc structure. We reexamine the problem by developing a new, two-fluid model for the structure of the accretion disc that includes the dynamical effect of the relativistic particle pressure, combined with the pressure of the background (thermal) gas. The new model is analogous to the two-fluid model of cosmic ray acceleration in supernova-driven shock waves. As part of the model, we also develop a new set of shock jump conditions, which are solved along with the hydrodynamic conservation equations to determine the structure of the accretion disc. The solutions include the formation of a mildly relativistic outflow (jet) at the shock radius, driven by the relativistic particles accelerated in the disc. One of our main conclusions is that in the context of the new two-fluid accretion model, global smooth (shock-free) solutions do not exist, and the disc must always contain a standing shock wave, at least in the inviscid case considered here.
Kim, K. W.; Hur, H. J.; Choi, J. H.; Kim, H. S. [Gyeongju Univ., Gyeongju (Korea, Republic of)
2007-04-15
The physico-chemical characteristics of the categorized aerosol with soil-related mineral species, anthropogenic-related heavy metal species, and aerosol-acidity-related element were analyzed based on the air-mass pathways. The lowest value of 0.6 {+-} 0.1 g m-3 was observed during the intensive fall period of 2005. The mass concentration of sulfur (S) was the highest in the intensive spring period and the lowest in the intensive summer period. The frequencies of the EM, the WC, the SC, and the NC events were 6, 17, 3, and 7, respectively. The continental air-mass-pathway categories were calculated consisting of 85% of the total 40 events whereas the marine air-mass-pathway categories were of 15%. The nanoparticles observed at the national park area of Gyeongju were estimated to be affected by soil-related elements when the air mass came from the western area of the Asian continent and to be predominantly affected by anthropogenic-related elements when air mass came from the northern area of the Asian continent through Korean peninsula. Soil-related elements were mainly observed in particles with sizes greater than 560 nm. The average mass fraction of anthropogenic-related elements was relatively much higher in the particle size range less than 320 nm.
Kim, K. W.; Hur, H. J.; Choi, J. H.; Kim, H. S. [Gyeongju Univ., Gyeongju (Korea, Republic of)
2007-04-15
The physico-chemical characteristics of the categorized aerosol with soil-related mineral species, anthropogenic-related heavy metal species, and aerosol-acidity-related element were analyzed based on the air-mass pathways. The lowest value of 0.6 {+-} 0.1 g m-3 was observed during the intensive fall period of 2005. The mass concentration of sulfur (S) was the highest in the intensive spring period and the lowest in the intensive summer period. The frequencies of the EM, the WC, the SC, and the NC events were 6, 17, 3, and 7, respectively. The continental air-mass-pathway categories were calculated consisting of 85% of the total 40 events whereas the marine air-mass-pathway categories were of 15%. The nanoparticles observed at the national park area of Gyeongju were estimated to be affected by soil-related elements when the air mass came from the western area of the Asian continent and to be predominantly affected by anthropogenic-related elements when air mass came from the northern area of the Asian continent through Korean peninsula. Soil-related elements were mainly observed in particles with sizes greater than 560 nm. The average mass fraction of anthropogenic-related elements was relatively much higher in the particle size range less than 320 nm.
H. F. Wang
2014-01-01
Full Text Available Support looseness fault is a type of common fault in aeroengine. Serious looseness fault would emerge under larger unbalanced force, which would cause excessive vibration and even lead to rubbing fault, so it is important to analyze and recognize looseness fault effectively. In this paper, based on certain type turbofan engine structural features, a rotor-support-casing whole model for certain type turbofan aeroengine is established. The rotor and casing systems are modeled by means of the finite element beam method; the support systems are modeled by lumped-mass model; the support looseness fault model is also introduced. The coupled system response is obtained by numerical integral method. In this paper, based on the casing acceleration signals, the impact characteristics of symmetrical stiffness and asymmetric stiffness models are analyzed, finding that the looseness fault would lead to the longitudinal asymmetrical characteristics of acceleration time domain wave and the multiple frequency characteristics, which is consistent with the real trial running vibration signals. Asymmetric stiffness looseness model is verified to be fit for aeroengine looseness fault model.
Accelerated gravitational wave parameter estimation with reduced order modeling.
Canizares, Priscilla; Field, Scott E; Gair, Jonathan; Raymond, Vivien; Smith, Rory; Tiglio, Manuel
2015-02-20
Inferring the astrophysical parameters of coalescing compact binaries is a key science goal of the upcoming advanced LIGO-Virgo gravitational-wave detector network and, more generally, gravitational-wave astronomy. However, current approaches to parameter estimation for these detectors require computationally expensive algorithms. Therefore, there is a pressing need for new, fast, and accurate Bayesian inference techniques. In this Letter, we demonstrate that a reduced order modeling approach enables rapid parameter estimation to be performed. By implementing a reduced order quadrature scheme within the LIGO Algorithm Library, we show that Bayesian inference on the 9-dimensional parameter space of nonspinning binary neutron star inspirals can be sped up by a factor of ∼30 for the early advanced detectors' configurations (with sensitivities down to around 40 Hz) and ∼70 for sensitivities down to around 20 Hz. This speedup will increase to about 150 as the detectors improve their low-frequency limit to 10 Hz, reducing to hours analyses which could otherwise take months to complete. Although these results focus on interferometric gravitational wave detectors, the techniques are broadly applicable to any experiment where fast Bayesian analysis is desirable.
A comprehensive study of back-reaction and effective acceleration in generic LTB dust models
Sussman, Roberto A
2011-01-01
We provide a thorough examination of the conditions for the existence of back-reaction and an "effective" acceleration (in the context of Buchert's averaging formalism) in regular generic spherically symmetric Lemaitre-Tolman-Bondi (LTB) dust models. By considering arbitrary spherical comoving domains, we verify rigorously the fulfillment of these conditions expressed in terms of suitable scalar variables that are evaluated at the domains' boundaries. Effective deceleration necessarily occurs in all domains in: (a) the asymptotic radial range of models converging to a FLRW background, (b) the asymptotic time range of non-vacuum hyperbolic models, (c) LTB self-similar solutions and (d) near a simultaneous big bang. Accelerating domains are proven to exist in the following scenarios: (i) central vacuum regions, (ii) central (non-vacuum) density voids, (iii) the intermediate radial range of models converging to a FLRW background, (iv) the asymptotic radial range of models converging to a Minkowski vacuum and (v)...
Modeling of a self-healing process in blast furnace slag cement exposed to accelerated carbonation
Zemskov, S.V.; Ahmad, B.; Copuroglu, O.; Vermolen, F.J.
2013-01-01
In the current research, a mathematical model for the post-damage improvement of the carbonated blast furnace slag cement (BFSC) exposed to accelerated carbonation is constructed. The study is embedded within the framework of investigating the effect of using lightweight expanded clay aggregate, whi
Development of an Efficient GPU-Accelerated Model for Fully Nonlinear Water Waves
of an optimized sequential single-CPU algorithm based on a flexible-order Finite Difference Method. High performance is pursued by utilizing many-core processing in the model focusing on GPUs for acceleration of code execution. This involves combining analytical methods with an algorithm redesign of the current...
Adaptive guidance law design based on characteristic model for reentry vehicles
YANG JunChun; HU Jun; NI MaoLin
2008-01-01
In this paper an adaptive guidance law based on the characteristic model is designed to track a reference drag acceleration for reentry vehicles like the Shuttle. The characteristic modeling method of linear constant systems is extended for single-input and single-output (SlSO) linear time-varying systems so that the characteristic model can be established for reentry vehicles. A new nonlinear differential golden-section adaptive control law is presented. When the coefficients belong to a bounded closed convex set and their rate of change meets some constraints, the uniformly asymptotic stability of the nonlinear differential golden-section adaptive control system is proved. The tracking control law, the nonlinear differential golden-section control law, and the revised logical integral control law are integrated to design an adaptive guidance law based on the characteristic model. This guidance law overcomes the disadvantage of the feedback linearization method which needs the precise model. Simulation results show that the proposed method has better performance of tracking the reference drag acceleration than the feedback linearization one.
Numerical modeling of gravitational wave sources accelerated by OpenCL
Khanna, Gaurav
2010-01-01
In this work, we make use of the OpenCL framework to accelerate an EMRI modeling application using the hardware accelerators -- Cell BE and Tesla CUDA GPU. We describe these compute technologies and our parallelization approach in detail, present our performance results, and then compare them with those from our previous implementations based on the native CUDA and Cell SDKs. The OpenCL framework allows us to execute identical source-code on both architectures and yet obtain strong performance gains that are comparable to what can be derived from the native SDKs.
Achievements in ISICs/SAPP collaborations for electromagnetic modeling of accelerators
Lee, Lie-Quan; Ge, Lixin; Li, Zenghai; Ng, Cho; Schussman, Greg; Ko, Kwok; Collaborators, ISICs/SAPP
2005-01-01
SciDAC provides the unique opportunity and the resources for the Electromagnetic System Simulations (ESS) component of High Energy Physics (HEP)'s Accelerator Science and Technology (AST) project to work with researchers in the Integrated Software Infrastructure Centres (ISICs) and Scientific Application Pilot Program (SAPP) to overcome challenging barriers in computer science and applied mathematics in order to perform the large-scale simulations required to support the ongoing R&D efforts on accelerators across the Office of Science. This paper presents the resultant achievements made under SciDAC in important areas of computational science relevant to electromagnetic modelling of accelerators which include nonlinear eigensolvers, shape optimization, adaptive mesh refinement, parallel meshing, and visualization.
Towards the final BSA modeling for the accelerator-driven BNCT facility at INFN LNL
Ceballos, C. [Centro de Aplicaciones Tecnlogicas y Desarrollo Nuclear, 5ta y30, Miramar, Playa, Ciudad Habana (Cuba); Esposito, J., E-mail: juan.esposito@lnl.infn.it [INFN, Laboratori Nazionali di Legnaro (LNL), via dell' Universita, 2, I-35020 Legnaro (PD) (Italy); Agosteo, S. [Politecnico di Milano, Dipartimento di Energia, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)] [INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy); Colautti, P.; Conte, V.; Moro, D. [INFN, Laboratori Nazionali di Legnaro (LNL), via dell' Universita, 2, I-35020 Legnaro (PD) (Italy); Pola, A. [Politecnico di Milano, Dipartimento di Energia, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)] [INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy)
2011-12-15
Some remarkable advances have been made in the last years on the SPES-BNCT project of the Istituto Nazionale di Fisica Nucleare (INFN) towards the development of the accelerator-driven thermal neutron beam facility at the Legnaro National Laboratories (LNL), aimed at the BNCT experimental treatment of extended skin melanoma. The compact neutron source will be produced via the {sup 9}Be(p,xn) reactions using the 5 MeV, 30 mA beam driven by the RFQ accelerator, whose modules construction has been recently completed, into a thick beryllium target prototype already available. The Beam Shaping Assembly (BSA) final modeling, using both neutron converter and the new, detailed, Be(p,xn) neutron yield spectra at 5 MeV energy recently measured at the CN Van de Graaff accelerator at LNL, is summarized here.
Towards the final BSA modeling for the accelerator-driven BNCT facility at INFN LNL.
Ceballos, C; Esposito, J; Agosteo, S; Colautti, P; Conte, V; Moro, D; Pola, A
2011-12-01
Some remarkable advances have been made in the last years on the SPES-BNCT project of the Istituto Nazionale di Fisica Nucleare (INFN) towards the development of the accelerator-driven thermal neutron beam facility at the Legnaro National Laboratories (LNL), aimed at the BNCT experimental treatment of extended skin melanoma. The compact neutron source will be produced via the (9)Be(p,xn) reactions using the 5 MeV, 30 mA beam driven by the RFQ accelerator, whose modules construction has been recently completed, into a thick beryllium target prototype already available. The Beam Shaping Assembly (BSA) final modeling, using both neutron converter and the new, detailed, Be(p,xn) neutron yield spectra at 5 MeV energy recently measured at the CN Van de Graaff accelerator at LNL, is summarized here. Copyright Â© 2011 Elsevier Ltd. All rights reserved.
An Annular Gap Acceleration Model for γ-ray Emission of Pulsars
无
2007-01-01
If the binding energy of the pulsar's surface is not so high (the case of a neutron star), both negative and positive charges will flow out freely from the surface of the star. An annular free flow model for γ-ray emission of pulsars is suggested. It is emphasized that:(1) Two kinds of acceleration regions (annular and core) need to be taken into account. The annular acceleration region is defined by the magnetic field lines that cross the null charge surface within the light cylinder. (2) If the potential drop in the annular region of a pulsar is high enough (normally the case for young pulsars), charges in both the annular and the core regions could be accelerated and produce primary gamma-rays. Secondary pairs are generated in both regions and stream outwards to power the broadband radiations. (3) The potential drop grows more rapidly in the annular region than in the core region. The annular acceleration process is a key process for producing the observed wide emission beams. (4)The advantages of both the polar cap and outer gap models are retained in this model. The geometric properties of the γ-ray emission from the annular flow are analogous to that presented in a previous work by Qiao et al., which match the observations well. (5) Since charges with different signs leave the pulsar through the annular and the core regions respectively, the current closure problem can be partially solved.
Accelerating PS model-based dynamic cardiac MRI using compressed sensing.
Zhang, Xiaoyong; Xie, Guoxi; Shi, Caiyun; Su, Shi; Zhang, Yongqin; Liu, Xin; Qiu, Bensheng
2016-02-01
High spatiotemporal resolution MRI is a challenging topic in dynamic MRI field. Partial separability (PS) model has been successfully applied to dynamic cardiac MRI by exploiting data redundancy. However, the model requires substantial preprocessing data to accurately estimate the model parameters before image reconstruction. Since compressed sensing (CS) is a potential technique to accelerate MRI by reducing the number of acquired data, the combination of PS and CS, named as Stepped-SparsePS, was introduced to accelerate the preprocessing data acquisition of PS in this work. The proposed Stepped-SparsePS method sequentially reconstructs a set of aliased dynamic images in each channel based on PS model and then the final dynamic images from the aliased images using CS. The results from numerical simulations and in vivo experiments demonstrate that Stepped-SparsePS could significantly reduce data acquisition time while preserving high spatiotemporal resolution. Copyright © 2015 Elsevier Inc. All rights reserved.
Li, Yan; Zhang, Liying; Kallakuri, Srinivasu; Zhou, Runzhou; Cavanaugh, John M
2011-09-01
A modified Marmarou impact acceleration model was developed to study the mechanical responses induced by this model and their correlation to traumatic axonal injury (TAI). Traumatic brain injury (TBI) was induced in 31 anesthetized male Sprague-Dawley rats (392±13 g) by a custom-made 450-g impactor from heights of 1.25 m or 2.25 m. An accelerometer and angular rate sensor measured the linear and angular responses of the head, while the impact event was captured by a high-speed video camera. TAI distribution along the rostro-caudal direction, as well as across the left and right hemispheres, was determined using β-amyloid precursor protein (β-APP) immunocytochemistry, and detailed TAI injury maps were constructed for the entire corpus callosum. Peak linear acceleration 1.25 m and 2.25 m impacts were 666±165 g and 907±501 g, respectively. Peak angular velocities were 95±24 rad/sec and 124±48 rad/sec, respectively. Compared to the 2.25-m group, the observed TAI counts in the 1.25-m impact group were significantly lower. Average linear acceleration, peak angular velocity, average angular acceleration, and surface righting time were also significantly different between the two groups. A positive correlation was observed between normalized total TAI counts and average linear acceleration (R(2)=0.612, plinear and angular acceleration response of the rat head during impact, not necessarily the drop height.
An OpenACC-Based Unified Programming Model for Multi-accelerator Systems
Kim, Jungwon [ORNL; Lee, Seyong [ORNL; Vetter, Jeffrey S [ORNL
2015-01-01
This paper proposes a novel SPMD programming model of OpenACC. Our model integrates the different granularities of parallelism from vector-level parallelism to node-level parallelism into a single, unified model based on OpenACC. It allows programmers to write programs for multiple accelerators using a uniform programming model whether they are in shared or distributed memory systems. We implement a prototype of our model and evaluate its performance with a GPU-based supercomputer using three benchmark applications.
An OpenACC-Based Unified Programming Model for Multi-accelerator Systems
Kim, Jungwon [ORNL; Lee, Seyong [ORNL; Vetter, Jeffrey S [ORNL
2015-01-01
This paper proposes a novel SPMD programming model of OpenACC. Our model integrates the different granularities of parallelism from vector-level parallelism to node-level parallelism into a single, unified model based on OpenACC. It allows programmers to write programs for multiple accelerators using a uniform programming model whether they are in shared or distributed memory systems. We implement a prototype of our model and evaluate its performance with a GPU-based supercomputer using three benchmark applications.
NONE
1993-07-01
The Accelerator System Model (ASM) is a computer program developed to model proton radiofrequency accelerators and to carry out system level trade studies. The ASM FORTRAN subroutines are incorporated into an intuitive graphical user interface which provides for the {open_quotes}construction{close_quotes} of the accelerator in a window on the computer screen. The interface is based on the Shell for Particle Accelerator Related Codes (SPARC) software technology written for the Macintosh operating system in the C programming language. This User Manual describes the operation and use of the ASM application within the SPARC interface. The Appendix provides a detailed description of the physics and engineering models used in ASM. ASM Version 1.0 is joint project of G. H. Gillespie Associates, Inc. and the Accelerator Technology (AT) Division of the Los Alamos National Laboratory. Neither the ASM Version 1.0 software nor this ASM Documentation may be reproduced without the expressed written consent of both the Los Alamos National Laboratory and G. H. Gillespie Associates, Inc.
Ellison, Donald C.; Warren, Donald C.; Bykov, Andrei M.
2016-03-01
We include a general form for the scattering mean free path, λmfp(p), in a nonlinear Monte Carlo model of relativistic shock formation and Fermi acceleration. Particle-in-cell simulations, as well as analytic work, suggest that relativistic shocks tend to produce short-scale, self-generated magnetic turbulence that leads to a scattering mean free path with a stronger momentum dependence than the λmfp ∝ p dependence for Bohm diffusion. In unmagnetized shocks, this turbulence is strong enough to dominate the background magnetic field so the shock can be treated as parallel regardless of the initial magnetic field orientation, making application to γ-ray bursts, pulsar winds, type Ibc supernovae, and extragalactic radio sources more straightforward and realistic. In addition to changing the scale of the shock precursor, we show that, when nonlinear effects from efficient Fermi acceleration are taken into account, the momentum dependence of λmfp(p) has an important influence on the efficiency of cosmic ray production as well as the accelerated particle spectral shape. These effects are absent in non-relativistic shocks and do not appear in relativistic shock models unless nonlinear effects are self-consistently described. We show, for limited examples, how the changes in Fermi acceleration translate to changes in the intensity and spectral shape of γ-ray emission from proton-proton interactions and pion-decay radiation.
Fonseca, Ricardo A; Fiúza, Frederico; Davidson, Asher; Tsung, Frank S; Mori, Warren B; Silva, Luís O
2013-01-01
A new generation of laser wakefield accelerators, supported by the extreme accelerating fields generated in the interaction of PW-Class lasers and underdense targets, promises the production of high quality electron beams in short distances for multiple applications. Achieving this goal will rely heavily on numerical modeling for further understanding of the underlying physics and identification of optimal regimes, but large scale modeling of these scenarios is computationally heavy and requires efficient use of state-of-the-art Petascale supercomputing systems. We discuss the main difficulties involved in running these simulations and the new developments implemented in the OSIRIS framework to address these issues, ranging from multi-dimensional dynamic load balancing and hybrid distributed / shared memory parallelism to the vectorization of the PIC algorithm. We present the results of the OASCR Joule Metric program on the issue of large scale modeling of LWFA, demonstrating speedups of over 1 order of magni...
Accelerated complete-linearization method for calculating NLTE model stellar atmospheres
Hubeny, I.; Lanz, T.
1992-01-01
Two approaches to accelerating the method of complete linearization for calculating NLTE model stellar atmospheres are suggested. The first one, the so-called Kantorovich variant of the Newton-Raphson method, consists of keeping the Jacobi matrix of the system fixed, which allows us to calculate the costly matrix inversions only a few times and then keep them fixed during the subsequent computations. The second method is an application of the Ng acceleration. Both methods are extremely easy to implement with any model atmosphere code based on complete linearization. It is demonstrated that both methods, and especially their combination, yield a rapidly and globally convergent algorithm, which takes 2 to 5 times less computer time, depending on the model at hand and the required accuracy, than the ordinary complete linearization. Generally, the time gain is more significant for more complicated models. The methods were tested for a broad range of atmospheric parameters, and in all cases they exhibited similar behavior. Ng acceleration applied on the Kantorovich variant thus offers a significant improvement of the standard complete-linearization method, and may now be used for calculating relatively involved NLTE model stellar atmospheres.
Clouds and Precipitation Simulated by the US DOE Accelerated Climate Modeling for Energy (ACME)
Xie, S.; Lin, W.; Yoon, J. H.; Ma, P. L.; Rasch, P. J.; Ghan, S.; Zhang, K.; Zhang, Y.; Zhang, C.; Bogenschutz, P.; Gettelman, A.; Larson, V. E.; Neale, R. B.; Park, S.; Zhang, G. J.
2015-12-01
A new US Department of Energy (DOE) climate modeling effort is to develop an Accelerated Climate Model for Energy (ACME) to accelerate the development and application of fully coupled, state-of-the-art Earth system models for scientific and energy application. ACME is a high-resolution climate model with a 0.25 degree in horizontal and more than 60 levels in the vertical. It starts from the Community Earth System Model (CESM) with notable changes to its physical parameterizations and other components. This presentation provides an overview on the ACME model's capability in simulating clouds and precipitation and its sensitivity to convection schemes. Results with using several state-of-the-art cumulus convection schemes, including those unified parameterizations that are being developed in the climate community, will be presented. These convection schemes are evaluated in a multi-scale framework including both short-range hindcasts and free-running climate simulations with both satellite data and ground-based measurements. Running climate model in short-range hindcasts has been proven to be an efficient way to understand model deficiencies. The analysis is focused on those systematic errors in clouds and precipitation simulations that are shared in many climate models. The goal is to understand what model deficiencies might be primarily responsible for these systematic errors.
Construct Method of Predicting Satisfaction Model Based on Technical Characteristics
YANG Xiao-an; DENG Qian; SUN Guan-long; ZHANG Wei-she
2011-01-01
In order to construct objective relatively mapping relationship model between customer requirements and product technical characteristics, a novel approach based on customer satisfactions information digging from case products and satisfaction information of expert technical characteristics was put forward in this paper. Technical characteristics evaluation values were expressed by rough number, and technical characteristics target sequence was determined on the basis of efficiency, cost type and middle type in this method. Use each calculated satisfactions of customers and technical characteristics as input and output elements to construct BP network model. And we use MATLAB software to simulate this BP network model based on the case of electric bicycles.
Richard, O; Richer, J; Turcotte, S; Turck-Chièze, S; Van den Berg, D A; Berg, Don A. Vanden
2002-01-01
Evolutionary models have been calculated for Pop II stars of 0.5 to 1.0$M_\\odot$ from the pre-main-sequence to the lower part of the giant branch. Rosseland opacities and radiative accelerations were calculated taking into account the concentration variations of 28 chemical species, including all species contributing to Rosseland opacities in the OPAL tables. The effects of radiative accelerations, thermal diffusion and gravitational settling are included. While models were calculated both for Z=0.00017 and 0.0017, we concentrate on models with Z=0.00017 in this paper. These are the first Pop II models calculated taking radiative acceleration into account. It is shown that, at least in a 0.8$M_\\odot$ star, it is a better approximation not to let Fe diffuse than to calculate its gravitational settling without including the effects of $g_{rad}(Fe)$. In the absence of any turbulence outside of convection zones, the effects of atomic diffusion are large mainly for stars more massive than 0.7$M_\\odot$. Overabundan...
Mereghetti, A; Cerutti, F; Versaci, R; Vlachoudis, V
2012-01-01
Extended FLUKA models of accelerator beam lines can be extremely complex: heavy to manipulate, poorly versatile and prone to mismatched positioning. We developed a framework capable of creating the FLUKA model of an arbitrary portion of a given accelerator, starting from the optics configuration and a few other information provided by the user. The framework includes a builder (LineBuilder), an element database and a series of configuration and analysis scripts. The LineBuilder is a Python program aimed at dynamically assembling complex FLUKA models of accelerator beam lines: positions, magnetic fields and scorings are automatically set up, and geometry details such as apertures of collimators, tilting and misalignment of elements, beam pipes and tunnel geometries can be entered at user’s will. The element database (FEDB) is a collection of detailed FLUKA geometry models of machine elements. This framework has been widely used for recent LHC and SPS beam-machine interaction studies at CERN, and led to a dra...
A transient MHD model applicable for the source of solar cosmic ray acceleration
Dryer, M.; Wu, S. T.
1981-01-01
A two-dimensional, time-dependent magnetohydrodynamic model is used to describe the possible mechanisms for the source of solar cosmic ray acceleration following a solar flare. The hypothesis is based on the propagation of fast mode MHD shocks following a sudden release of energy. In this presentation, the effects of initial magnetic topology and strength on the formation of MHD shocks have been studied. The plasma beta (thermal pressure/magnetic pressure) is considered as a measure of the initial, relative strength of the field. During dynamic mass motion, the Alfven Mach number is the more appropriate measure of the magnetic field's ability to control the outward motion. It is suggested that this model (computed self-consistently) provides the shock waves and the disturbed mass motion behind it as likely sources for solar cosmic ray acceleration.
Feng, J.; Padmore, H.; Wei, D. H.; Anders, S.; Wu, Y.; Scholl, A.; Robin, D.
2002-03-01
The modeling of the optical properties of the acceleration field and objective lens of a photoemission electron microscope (PEEM) is presented. Theory to calculate the aberrations of the extraction field was derived, and extended to include relativistic effects. An analysis of the microscope's electron optical performance and aberrations has been performed using an analytical model as well as a ray tracing method. Ray tracing has the flexibility needed for the assessment of aberrations where the geometry is too complex for analytical methods. This work shows that in the case of a simple PEEM front end of the acceleration gap and objective lens, the all orders ray tracing and full analytical treatments agree to very high precision. This allows us now to use the ray tracing method in situations where analytical methods are difficult, such as an aberration compensating electron mirror.
无
2009-01-01
The Tsallis distribution and the stretched exponential distribution were successfully used to fit the experimental data of turbulence particle acceleration published in Nature (2001), which manifested a clear departure from the normal distribution. These studies, however, fall short of a clear physical mechanism behind the statistical phenomenological description. In this study, we propose a multi- scale diffusion model which considers both normal diffusion in molecular-scale and anomalous diffu- sion in vortex-scale, and the latter is described by a novel fractal derivative modeling approach. This multi-scale model gives rise to a new probability density function which fits experimental data very well.
SUN HongGuang; CHEN Wen
2009-01-01
The Tsallis distribution and the stretched exponential distribution were successfully used to fit the experimental data of turbulence particle acceleration published in Nature (2001), which manifested a clear departure from the normal distribution. These studies, however, fall short of a clear physical mechanism behind the statistical phenomenological description. In this study, we propose a multi-scale diffusion model which considers both normal diffusion in molecular-scale and anomalous diffu-sion in vortex-scale, and the latter is described by a novel fractal derivative modeling approach. This multi-scale model gives rise to a new probability density function which fits experimental data very well.
Coupled Mechanical-Electrochemical-Thermal Modeling for Accelerated Design of EV Batteries
Santhanagopalan, Shriram; Zhang, Chao; Kim, Gi-Heon; Pesaran, Ahmad A.
2015-05-03
This presentation provides an overview of the mechanical electrochemical-thermal (M-ECT) modeling efforts. The physical phenomena occurring in a battery are many and complex and operate at different scales (particle, electrodes, cell, and pack). A better understanding of the interplay between different physics occurring at different scales through modeling could provide insight to design improved batteries for electric vehicles. Work funded by the U.S. DOE has resulted in development of computer-aided engineering (CAE) tools to accelerate electrochemical and thermal design of batteries; mechanical modeling is under way. Three competitive CAE tools are now commercially available.
Calibration of the Nonlinear Accelerator Model at the Diamond Storage Ring
Bartolini, Riccardo; Rowland, James; Martin, Ian; Schmidt, Frank
2010-01-01
The correct implementation of the nonlinear ring model is crucial to achieve the top performance of a synchrotron light source. Several dynamics quantities can be used to compare the real machine with the model and eventually to correct the accelerator. Most of these methods are based on the analysis of turn-by-turn data of excited betatron oscillations. We present the experimental results of the campaign of measurements carried out at the Diamond. A combination of Frequency Map Analysis (FMA) and detuning with momentum measurements has allowed a precise calibration of the nonlinear model capable of reproducing the nonlinear beam dynamics in the storage ring
Comparison of solar wind velocity measurements with a theoretical acceleration model
Coles, W.A. (Univ. of California, La Jolla (United States)); Esser, R. (Univ. of Tromsoe (Norway)); Loevhaug, U.P. (EISCAT, Ramfjordbotn (Norway)); Markkanen, J. (Geophysical Observatory, Sodankyla (Finland))
1991-08-01
Interplanetary radio scintillation (IPS) measurements of the solar wind velocity were made using the receiving antennas of the European Incoherent Scatter Facility (EISCAT) radar system in northern Scandinavia from June through October 1990. The observations, which cover the distance range from 11 to 90 R{sub s} from Sun center, were taken with sufficient density to measure the same stream at two (or more) different distances. The deduced velocities are in the range 100 {approx lt} U {approx lt} 540 km s{sup {minus}1}. The authors selected from 192 observations, 16 examples of streams observed with good radial alignment, of which 12 were observed unchanged for several days. The measured velocities are compared with calculations based on a two-fluid solar wind model with Alfven waves. In eight cases the measurements are in good agreement with the model when a moderate amount of wave energy is added to the flow. In four cases the observed streams show low or moderate velocities below, say, 20 R{sub s} but then accelerate fast at larger distances from the Sun. This delayed acceleration is much steeper than the acceleration in the model at these distances. In the remaining four cases the streams seem to reach their final velocities much closer to the base than in other cases, and they are not observed to accelerate much between 10 and 90 R{sub s}. At these distances all related solar wind models they have seen give the same results; they all fit half the data, and none can fit the other half.
Modelling of radiation losses for ion acceleration at ultra-high laser intensities
Capdessus Remi
2013-11-01
Full Text Available Radiation losses of charged particles can become important in ultra high intensity laser plasma interaction. This process is described by the radiation back reaction term in the electron equation of motion. This term is implemented in the relativistic particle-in-cell code by using a renormalized Lorentz-Abraham-Dirac model. In the hole boring regime case of laser ion acceleration it is shown that radiation losses results in a decrease of the piston velocity.
Hamdar, Samer H; Treiber, Martin
2014-01-01
We investigate a utility-based approach for driver car-following behavioral modeling while analyzing different aspects of the model characteristics especially in terms of capturing different fundamental diagram regions and safety proxy indices. The adopted model came from an elementary thought where drivers associate subjective utilities for accelerations (i.e. gain in travel times) and subjective dis-utilities for decelerations (i.e. loss in travel time) with a perceived probability of being involved in rear-end collision crashes. Following the testing of the model general structure, the authors translate the corresponding behavioral psychology theory - prospect theory - into an efficientmicroscopic traffic modeling with more elaborate stochastic characteristics considered in a risk-taking environment. The formulated model offers a better understanding of drivers behavior, particularly under extreme/incident conditions.
Poteshin, S. S.; Chernyshev, D. M.; Sysoev, Alexey A.; Sysoev, Alexander A.
Currently axially symmetric type of analyzer with an electrostatic sector fields (AESF) is rarely used to construct time-of-flight mass spectrometers. The main drawback, hindering the wider use of the analyzers of this type, is the lack of chromatic second-order focusing by energy. However, the configuration of AESF in combination with orthogonal accelerator (OA) allows to achieved it through compensation of energy aberrations of the analyzer in the system of orthogonal input of the ion beam. In the presented work the results of theoretical calculation, simulation and experimentally obtained data are compared. Characteristics of the analyzer with OA in a large extent depend on the parameters of the incoming ion beam. Data of modeling the 2nd stage of gas-dynamic interface, which have the greatest influence on the parameters of the ion beam, is provided.
Beyer, J C; Stotzer, E J; Hart, A; de Supinski, B R
2011-03-15
OpenMP [13] is the dominant programming model for shared-memory parallelism in C, C++ and Fortran due to its easy-to-use directive-based style, portability and broad support by compiler vendors. Similar characteristics are needed for a programming model for devices such as GPUs and DSPs that are gaining popularity to accelerate compute-intensive application regions. This paper presents extensions to OpenMP that provide that programming model. Our results demonstrate that a high-level programming model can provide accelerated performance comparable to hand-coded implementations in CUDA.
Guo, X.; Ditmar, P.; Zhao, Q.; Klees, R.; Farahani, H. H.
2017-09-01
GPS data collected by satellite gravity missions can be used for extracting the long-wavelength part of the Earth's gravity field. We propose a new data processing method which makes use of the `average acceleration' approach to gravity field modelling. In this method, satellite accelerations are directly derived from GPS carrier phase measurements with an epoch-differenced scheme. As a result, no ambiguity solutions are needed and the systematic errors that do not change much from epoch to epoch are largely eliminated. The GPS data collected by the Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) satellite mission are used to demonstrate the added value of the proposed method. An analysis of the residual accelerations shows that accelerations derived in this way are more precise, with noise being reduced by about 20 and 5% at the cross-track component and the other two components, respectively, as compared to those based on kinematic orbits. The accelerations obtained in this way allow the recovery of the gravity field to a slightly higher maximum degree compared to the solution based on kinematic orbits. Furthermore, the gravity field solution has an overall better performance. Errors in spherical harmonic coefficients are smaller, especially at low degrees. The cumulative geoid height error is reduced by about 15 and 5% up to degree 50 and 150, respectively. An analysis in the spatial domain shows that large errors along the geomagnetic equator, which are caused by a high electron density coupled with large short-term variations, are substantially reduced. Finally, the new method allows for a better observation of mass transport signals. In particular, sufficiently realistic signatures of regional mass anomalies in North America and south-west Africa are obtained.
Guo, X.; Ditmar, P.; Zhao, Q.; Klees, R.; Farahani, H. H.
2017-02-01
GPS data collected by satellite gravity missions can be used for extracting the long-wavelength part of the Earth's gravity field. We propose a new data processing method which makes use of the `average acceleration' approach to gravity field modelling. In this method, satellite accelerations are directly derived from GPS carrier phase measurements with an epoch-differenced scheme. As a result, no ambiguity solutions are needed and the systematic errors that do not change much from epoch to epoch are largely eliminated. The GPS data collected by the Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) satellite mission are used to demonstrate the added value of the proposed method. An analysis of the residual accelerations shows that accelerations derived in this way are more precise, with noise being reduced by about 20 and 5% at the cross-track component and the other two components, respectively, as compared to those based on kinematic orbits. The accelerations obtained in this way allow the recovery of the gravity field to a slightly higher maximum degree compared to the solution based on kinematic orbits. Furthermore, the gravity field solution has an overall better performance. Errors in spherical harmonic coefficients are smaller, especially at low degrees. The cumulative geoid height error is reduced by about 15 and 5% up to degree 50 and 150, respectively. An analysis in the spatial domain shows that large errors along the geomagnetic equator, which are caused by a high electron density coupled with large short-term variations, are substantially reduced. Finally, the new method allows for a better observation of mass transport signals. In particular, sufficiently realistic signatures of regional mass anomalies in North America and south-west Africa are obtained.
A Data-driven Analytic Model for Proton Acceleration by Large-scale Solar Coronal Shocks
Kozarev, Kamen A.; Schwadron, Nathan A.
2016-11-01
We have recently studied the development of an eruptive filament-driven, large-scale off-limb coronal bright front (OCBF) in the low solar corona, using remote observations from the Solar Dynamics Observatory’s Advanced Imaging Assembly EUV telescopes. In that study, we obtained high-temporal resolution estimates of the OCBF parameters regulating the efficiency of charged particle acceleration within the theoretical framework of diffusive shock acceleration (DSA). These parameters include the time-dependent front size, speed, and strength, as well as the upstream coronal magnetic field orientations with respect to the front’s surface normal direction. Here we present an analytical particle acceleration model, specifically developed to incorporate the coronal shock/compressive front properties described above, derived from remote observations. We verify the model’s performance through a grid of idealized case runs using input parameters typical for large-scale coronal shocks, and demonstrate that the results approach the expected DSA steady-state behavior. We then apply the model to the event of 2011 May 11 using the OCBF time-dependent parameters derived by Kozarev et al. We find that the compressive front likely produced energetic particles as low as 1.3 solar radii in the corona. Comparing the modeled and observed fluences near Earth, we also find that the bulk of the acceleration during this event must have occurred above 1.5 solar radii. With this study we have taken a first step in using direct observations of shocks and compressions in the innermost corona to predict the onsets and intensities of solar energetic particle events.
A model for emission from jets in X-ray binaries: consequences of a single acceleration episode
A. Pe'er; P. Casella
2009-01-01
There is strong evidence for powerful jets in the low/hard state of black hole X-ray binaries (BHXRBs). Here, we present a model in which electrons are accelerated once at the base of the jet, and are cooled by synchrotron emission and possible adiabatic energy losses. The accelerated electrons assu
Yared Abayneh Abebe
2016-11-01
Full Text Available Modelling floods and flood-related disasters has become priority for many researchers and practitioners. Currently, there are several options that can be used for modelling floods in urban areas and the present work attempts to investigate effectiveness of different model formulations in modelling supercritical and transcritical flow conditions. In our work, we use the following three methods for modelling one-dimensional (1D flows: the MIKE 11 flow model, Kutija’s method, and the Roe scheme. We use two methods for modelling two-dimensional (2D flows: the MIKE21 flow model and a non-inertia 2D model. Apart from the MIKE11 and MIKE21 models, the code for all other models was developed and used for the purposes of the present work. The performance of the models was evaluated using hypothetical case studies with the intention of representing some configurations that can be found in urban floodplains. The present work does not go into the assessment of these models in modelling various topographical features that may be found on urban floodplains, but rather focuses on how they perform in simulating supercritical and transcritical flows. The overall findings are that the simplified models which ignore convective acceleration terms (CATs in the momentum equations may be effectively used to model urban flood plains without a significant loss of accuracy.
Ribeiro, Candido M. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Fisica]. E-mail: candido_1998@yahoo.com; Patrao, Karla C.S.; Pereira, Walsan W.; Fonseca, Evaldo S.; Giannoni, Ricardo A. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Lab. de Neutrons]. E-mails: karla@ird.gov.br; walsan@ird.gov.br; Batista, Delano V.S. [Instituto Nacional do Cancer (INCa), Rio de Janeiro, RJ (Brazil). Setor de Fisica Medica]. E-mail: delano@inca.gov.br
2007-07-01
Currently, in Radiotherapy, the use of linear accelerators is becoming each time more common. From Radiation Protection point of view, these instruments represent an advance in relation to the cobalt and caesium irradiators, mainly due to absence of the radioactive material. On the other hand, accelerators with the energies superior to 10 MeV produce contamination of the therapeutic beam with the presence of neutrons generated in the interaction of high-energy photons with high atomic number materials from the own irradiator. The present work carries through measurements in a linear accelerator of 15 MeV using three neutron area monitors for a comparison of the response of these instruments, evaluating its adequacy to this measurement. Characteristics of use and operation associates to parameters such as: monitor dead time, monitor gamma rejection, and calibration results are also analyzed in this study. (author)
Acceleration of the solar wind in a spherical coordinate kinetic model
Dyadechkin, Sergey; Kallio, Esa; Alho, Markku; Semenov, Vladimir; Erkaev, Nikolay
2015-04-01
We have studied the acceleration of the solar wind protons by using a spherical coordinate kinetic hybrid model (HYBs). The model treats ions as particles while electrons form a massless, charge neutralizing fluid. The model includes the gravitation, the electron pressure and the jxB forces. We have studied a magnetized and a non-magnetized solar wind cases and performed simulations for different isothermal electron temperatures by using the same initial Maxwellian velocity distribution function for protons. We show in the presentation of how the bulk velocity, the plasma density, the electric potential and the velocity distribution function of protons depend on the radial distance from the Sun to several Astronomical Units. The derived velocity and density profiles are compared with those of the Parker's solar wind model. Finally, extensions of the model and its applicability for a space weather modelling are discussed.
Characteristic modeling and the control of flexible structure
吴宏鑫; 刘一武; 刘忠汉; 解永春
2001-01-01
Appropriate modeling for a controlled plant has been a remarkable problem in the control field. A new modeling theory, i.e. characteristic modeling, is roundly demonstrated. It is deduced in detail that a general linear constant high_order system can be equivalently described with a two_order time_varying difference equation. The application of the characteristic modeling method to the control of flexible structure is also introduced. Especially, as an example, the Hubble Space Telescope is used to illustrate the application of the characteristic modeling and adaptive control method proposed in this paper.
Seismicity acceleration model and its application to several earthquake regions in China
无
1999-01-01
With the theory of subcritical crack growth, we can deduce the fundamental equation of regional seismicity acceleration model. Applying this model to intraplate earthquake regions, we select three earthquake subplates: North China Subplate, Chuan-Dian Block and Xinjiang Subplate, and divide the three subplates into seven researched regions by the difference of seismicity and tectonic conditions. With the modified equation given by Sornette and Sammis (1995), we analysis the seismicity of each region. To those strong earthquakes already occurred in these region, the model can give close fitting of magnitude and occurrence time, and the result in this article indicates that the seismicity acceleration model can also be used for describing the seismicity of intraplate. In the article, we give the magnitude and occurrence time of possible strong earthquakes in Shanxi, Ordos, Bole-Tuokexun, Ayinke-Wuqia earthquake regions. In the same subplate or block, the earthquake periods for each earthquake region are similar in time interval. The constant αin model can be used to describe the intensity of regional seismicity, and for the Chinese Mainland, α is 0.4 generally. To the seismicity in Taiwan and other regions with complex tectonic conditions, the model does not fit well at present.
Aston, Graeme; Brophy, John R.
1987-01-01
Results from a series of experiments to determine the effect of accelerator grid mount geometry on the performance of the J-series ion optics assembly are described. Three mounting schemes, two flexible and one rigid, are compared for their relative ion extraction capability over a range of total accelerating voltages. The largest ion beam current, for the maximum total voltage investigated, is shown to occur using one of the flexible grid mounting geometries. However, at lower total voltages and reduced engine input power levels, the original rigid J-series ion optics accelerator grid mounts result in marginally better grid system performance at the same cold interelectrode gap.
Slow Solar Wind: Observable Characteristics for Constraining Modelling
Ofman, L.; Abbo, L.; Antiochos, S. K.; Hansteen, V. H.; Harra, L.; Ko, Y. K.; Lapenta, G.; Li, B.; Riley, P.; Strachan, L.; von Steiger, R.; Wang, Y. M.
2015-12-01
The Slow Solar Wind (SSW) origin is an open issue in the post SOHO era and forms a major objective for planned future missions such as the Solar Orbiter and Solar Probe Plus.Results from spacecraft data, combined with theoretical modeling, have helped to investigate many aspects of the SSW. Fundamental physical properties of the coronal plasma have been derived from spectroscopic and imaging remote-sensing data and in-situ data, and these results have provided crucial insights for a deeper understanding of the origin and acceleration of the SSW.Advances models of the SSW in coronal streamers and other structures have been developed using 3D MHD and multi-fluid equations.Nevertheless, there are still debated questions such as:What are the source regions of SSW? What are their contributions to the SSW?Which is the role of the magnetic topology in corona for the origin, acceleration and energy deposition of SSW?Which are the possible acceleration and heating mechanisms for the SSW?The aim of this study is to present the insights on the SSW origin and formationarisen during the discussions at the International Space Science Institute (ISSI) by the Team entitled ''Slowsolar wind sources and acceleration mechanisms in the corona'' held in Bern (Switzerland) in March2014--2015. The attached figure will be presented to summarize the different hypotheses of the SSW formation.
The impact of accelerator processors for high-throughput molecular modeling and simulation.
Giupponi, G; Harvey, M J; De Fabritiis, G
2008-12-01
The recent introduction of cost-effective accelerator processors (APs), such as the IBM Cell processor and Nvidia's graphics processing units (GPUs), represents an important technological innovation which promises to unleash the full potential of atomistic molecular modeling and simulation for the biotechnology industry. Present APs can deliver over an order of magnitude more floating-point operations per second (flops) than standard processors, broadly equivalent to a decade of Moore's law growth, and significantly reduce the cost of current atom-based molecular simulations. In conjunction with distributed and grid-computing solutions, accelerated molecular simulations may finally be used to extend current in silico protocols by the use of accurate thermodynamic calculations instead of approximate methods and simulate hundreds of protein-ligand complexes with full molecular specificity, a crucial requirement of in silico drug discovery workflows.
Accelerating 3D Visualization in Reservoir Modeling System with Programmable Hardware
Lin Liu
2013-05-01
Full Text Available This study presents a new method on 3D visualization in reservoir modeling system by using the computation power of modern programmable Graphics hardware (GPU. The proposed scheme is devised to achieve parallel processing of massive reservoir logging data. By taking advantage of the GPU's parallel processing capability, moreover, the performance of our scheme is discussed in comparison with that of the implementation entirely running on CPU. Experimental results clearly show that the proposed parallel processing can remarkably accelerate the data clustering task. Especially, although data-transferring from GPU to CPU is generally costly, acceleration by GPU is significant to save the total execution time of data-clustering and also significantly alleviates the computing load on CPU.
Kinetic modeling of particle acceleration in a solar null point reconnection region
Baumann, Gisela; Haugbølle, Troels; Nordlund, Åke
2013-01-01
The primary focus of this paper is on the particle acceleration mechanism in solar coronal 3D reconnection null-point regions. Starting from a potential field extrapolation of a SOHO magnetogram taken on 2002 November 16, we first performed MHD simulations with horizontal motions observed by SOHO...... applied to the photospheric boundary of the computational box. After a build-up of electric current in the fan-plane of the null-point, a sub-section of the evolved MHD data was used as initial and boundary conditions for a kinetic particle-in-cell model of the plasma. We find that sub......-relativistic electron acceleration is mainly driven by a systematic electric field in the current sheet. A non-thermal population of electrons with a power-law distribution in energy forms, featuring a power-law index of about -1.75. This work provides a first step towards bridging the gap between macroscopic scales...
Ellison, Donald C; Bykov, Andrei M
2015-01-01
We include a general form for the scattering mean free path in a nonlinear Monte Carlo model of relativistic shock formation and Fermi acceleration. Particle-in-cell (PIC) simulations, as well as analytic work, suggest that relativistic shocks tend to produce short-scale, self-generated magnetic turbulence that leads to a scattering mean free path (mfp) with a stronger momentum dependence than the mfp ~ p dependence for Bohm diffusion. In unmagnetized shocks, this turbulence is strong enough to dominate the background magnetic field so the shock can be treated as parallel regardless of the initial magnetic field orientation, making application to gamma-ray bursts (GRBs), pulsar winds, Type Ibc supernovae, and extra-galactic radio sources more straightforward and realistic. In addition to changing the scale of the shock precursor, we show that, when nonlinear effects from efficient Fermi acceleration are taken into account, the momentum dependence of the mfp has an important influence on the efficiency of cosm...
Modeling beam-driven and laser-driven plasma Wakefield accelerators with XOOPIC
Bruhwiler, David L.; Giacone, Rodolfo; Cary, John R.; Verboncoeur, John P.; Mardahl, Peter; Esarey, Eric; Leemans, Wim
2000-06-01
We present 2-D particle-in-cell simulations of both beam-driven and laser-driven plasma wakefield accelerators, using the object-oriented code XOOPIC, which is time explicit, fully electromagnetic, and capable of running on massively parallel supercomputers. Simulations of laser-driven wakefields with low ({approximately} 10{sup 16} W/cm{sup 2}) and high ({approximately} 10{sup 18} W/cm{sup 2}) peak intensity laser pulses are conducted in slab geometry, showing agreement with theory. Simulations of the E-157 beam wakefield experiment at the Stanford Linear Accelerator Center, in which a 30 GeV electron beam passes through 1 m of preionized lithium plasma, are conducted in cylindrical geometry, obtaining good agreement with previous work. We briefly describe some of the more significant modifications to XOOPIC required by this work, and summarize the issues relevant to modeling electron-neutral collisions in a particle-in-cell code.
Lee, Shiu-Hang; Ellison, Donald C
2008-01-01
We present a 3-dimensional model of supernova remnants (SNRs) where the hydrodynamical evolution of the remnant is modeled consistently with nonlinear diffusive shock acceleration occuring at the outer blast wave. The model includes particle escape and diffusion outside of the forward shock, and particle interactions with arbitrary distributions of external ambient material, such as molecular clouds. We include synchrotron emission and cooling, bremsstrahlung radiation, neutral pion production, inverse-Compton (IC), and Coulomb energy-loss. Boardband spectra have been calculated for typical parameters including dense regions of gas external to a 1000 year old SNR. In this paper, we describe the details of our model but do not attempt a detailed fit to any specific remnant. We also do not include magnetic field amplification (MFA), even though this effect may be important in some young remnants. In this first presentation of the model we don't attempt a detailed fit to any specific remnant. Our aim is to devel...
A Model for the Escape of Solar-Flare Accelerated Particles
Masson, Sophie; DeVore, C Rick
2013-01-01
Impulsive solar energetic particles (SEP) bursts are frequently observed in association with so-called eruptive flares consisting of a coronal mass ejection (CME) and a flare. These highly prompt SEPs are believed to be accelerated by the flare rather than by a CME shock, but in the standard flare model the accelerated particles should remain trapped in the corona or in the ejected plas- moid. In this case, however, the particles would reach the Earth only after a delay of many hours to a few days. We present a new model that can account for the prompt injection of energetic particles onto open interplanetary magnetic flux tubes. The basic idea underlying the model is that magnetic reconnection between the ejection and external open field allows for the release of the ener- getic particles. We demonstrate the model using 2.5D MHD simulations of a CME/flare event. The model system consists of a multipolar field with a coro- nal null point and with photospheric shear imposed at a polarity inversion line, as in ...
Zhang, G.; Lu, D.; Webster, C.
2014-12-01
The rational management of oil and gas reservoir requires an understanding of its response to existing and planned schemes of exploitation and operation. Such understanding requires analyzing and quantifying the influence of the subsurface uncertainties on predictions of oil and gas production. As the subsurface properties are typically heterogeneous causing a large number of model parameters, the dimension independent Monte Carlo (MC) method is usually used for uncertainty quantification (UQ). Recently, multilevel Monte Carlo (MLMC) methods were proposed, as a variance reduction technique, in order to improve computational efficiency of MC methods in UQ. In this effort, we propose a new acceleration approach for MLMC method to further reduce the total computational cost by exploiting model hierarchies. Specifically, for each model simulation on a new added level of MLMC, we take advantage of the approximation of the model outputs constructed based on simulations on previous levels to provide better initial states of new simulations, which will help improve efficiency by, e.g. reducing the number of iterations in linear system solving or the number of needed time-steps. This is achieved by using mesh-free interpolation methods, such as Shepard interpolation and radial basis approximation. Our approach is applied to a highly heterogeneous reservoir model from the tenth SPE project. The results indicate that the accelerated MLMC can achieve the same accuracy as standard MLMC with a significantly reduced cost.
Benson, A. J.; Barnes, G. R.
1973-01-01
Human subjects were exposed to a linear acceleration vector that rotated in the transverse plane of the skull without angular counterrotation. Lateral eye movements showed a sinusoidal change in slow phase velocity and an asymmetry or bias in the same direction as vector rotation. A model is developed that attributes the oculomotor response to otolithic mechanisms. It is suggested that the bias component is the manifestation of torsion of the statoconial plaque relative to the base of the utricular macula and that the sinusoidal component represents the translational oscillation of the statoconia. The model subsumes a hypothetical neural mechanism which allows x- and y-axis accelerations to be resolved. Derivation of equations of motion for the statoconial plaque in torsion and translation, which take into account forces acting in shear and normal to the macula, yield estimates of bias and sinusoidal components that are in qualitative agreement with the diverse experimental findings.
Suwada, Tsuyoshi; Satoh, Masanori; Telada, Souichi; Minoshima, Kaoru
2013-09-01
A laser-based alignment system with a He-Ne laser has been newly developed in order to precisely align accelerator units at the KEKB injector linac. The laser beam was first implemented as a 500-m-long fiducial straight line for alignment measurements. We experimentally investigated the propagation and stability characteristics of the laser beam passing through laser pipes in vacuum. The pointing stability at the last fiducial point was successfully obtained with the transverse displacements of ±40 μm level in one standard deviation by applying a feedback control. This pointing stability corresponds to an angle of ±0.08 μrad. This report contains a detailed description of the experimental investigation for the propagation and stability characteristics of the laser beam in the laser-based alignment system for long-distance linear accelerators.
Modeling of spectral characteristics of blue LEDs
Thorseth, Anders
2010-01-01
are expected to vary with current and junction temperature. Commercial high power blue LEDs were measured with respect to spectral distribution and chromaticity and the result was compared with the model predictions. We have found that the models predict significantly different results with respect...
Kerh, T; Lin, J. S; Gunaratnam, D
2012-01-01
.... This paper is therefore aimed at developing a neural network model, based on available microtremor measurement and on-site soil boring test data, for predicting peak ground acceleration at a site...
Gary, Dale E.; Chen, Bin; Bastian, Timothy S.; Shen, Chengcai; Krucker, Sam
2015-04-01
Solar eruptions and their associated solar flares are the most energetic particle accelerators in our solar system. Yet the acceleration mechanism remains uncertain. A possible candidate often invoked in the standard picture of solar eruptions is a termination shock, produced by fast reconnection outflows impinging upon dense, closed loops in a helmet-type geometry. However, the importance of termination shocks in solar particle acceleration remains controversial, mainly because there has been no direct detection of such shocks. Here we report direct imaging of the location and evolution of a termination shock during the rise phase of a solar eruption. The shock appears at radio wavelengths as a narrow surface sandwiched between multitudes of downward-moving plasma blobs and the underlying, newly-reconnected flaring loops, and evolves coherently with a loop-top hard X-ray source in the shock downstream region. The shock produces many short-lived, point-like radio sources, each interpreted as emission from a turbulence cell interacting with fast (nonthermal) electrons. These point-like radio sources clearly outline the termination shock front and their positions change in reaction to the arrival of the fast plasma blobs, which are well-reproduced by our numerical simulations based on a resistive magnetohydrodynamics reconnection model in a standard two-ribbon flare geometry. We further show that a temporary disruption of the shock coincides with a reduction of radio and hard X-ray emission associated with the energetic electron population. Our observations strongly favor a scenario in which the termination shock is responsible for accelerating electrons to high energies.
Acceleration of a Semi Implicit Non-hydrostatic Atmospheric Model on Many Core Architecture
Abdi, D. S.; Giraldo, F.; Wilcox, L.; Warburton, T.
2016-12-01
The Non-hydrostatic Unified Model of the Atmosphere (NUMA) uses high-order continuous and discontinuous Galerkin spatial discretization that result in high arithmetic intensity per-degree of freedom. Therefore, these methods are suitable for the future many-core and multi-core supercomputers with heterogeneous computing units. In our previous work, we have presented scalability of NUMA using explicit time integration that performed well on a GPU cluster. We achieved two orders of magnitude speedup over the CPU version of NUMA, while maintaining a 90% weak scaling efficiency using up to 16384 GPUs of the titan supercomputer. However, in operational numerical weather prediction, it is often necessary to use semi-implicit time integrators that allow for a much larger time step than explicit time integrators. A lot of machinery is required to enable semi-implcit time integration on the GPU and other accelerators. In this work, we will present the work on porting of the semi-implicit time integrators 1D and 3D IMEX, that require solving a system of linear equations at each time step. The scalability of the semi-implicit NUMA will be tested on supercomputers consisting of different accelerators such as CPUs, GPUs, KNL. The porting of NUMA to many-core architecture is done using a unified language called OCCA - that takes a `write once run everywhere' approach for different accelerators. To be able to scale well on future exa-scale supercomputers with heterogeneous accelerators, NUMA should be portable in-terms of both code and performance across different devices. The OCCA language's design is such that a node-per-thread approach is used on the GPU while an element-per-thread approach is used on the CPU. This makes OCCA highly performance portable and achieve results equalling that obtained with a native language (e.g. OpenMP or CUDA).
Accelerating dark energy models with anisotropic fluid in Bianchi type-$VI_{0}$ space-time
Pradhan, Anirudh
2012-01-01
Motivated by the increasing evidence for the need of a geometry that resembles Bianchi morphology to explain the observed anisotropy in the WMAP data, we have discussed some features of the Bianchi type-$VI_{0}$ universes in the presence of a fluid that wields an anisotropic equation of state (EoS) parameter in general relativity. We present two accelerating dark energy (DE) models with an anisotropic fluid in Bianchi type-$VI_{0}$ space-time. To prevail the deterministic solution we choose the scale factor $a(t) = \\sqrt{t^{n}e^{t}}$, which yields a time-dependent deceleration parameter (DP), representing a class of models which generate a transition of the universe from the early decelerating phase to the recent accelerating phase. Under the suitable condition, the anisotropic models approach to isotropic scenario. The EoS for dark energy $\\omega$ is found to be time-dependent and its existing range for derived models is in good agreement with the recent observations of SNe Ia data (Knop et al. 2003), SNe Ia...
Bilgili, D; Ryu, D; Ergönül, Ö; Ebrahimi, N
2016-03-01
Infectious diseases that can be spread directly or indirectly from one person to another are caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi. Infectious diseases remain one of the greatest threats to human health and the analysis of infectious disease data is among the most important application of statistics. In this article, we develop Bayesian methodology using parametric bivariate accelerated lifetime model to study dependency between the colonization and infection times for Acinetobacter baumannii bacteria which is leading cause of infection among the hospital infection agents. We also study their associations with covariates such as age, gender, apache score, antibiotics use 3 months before admission and invasive mechanical ventilation use. To account for singularity, we use Singular Bivariate Extreme Value distribution to model residuals in Bivariate Accelerated lifetime model under the fully Bayesian framework. We analyze a censored data related to the colonization and infection collected in five major hospitals in Turkey using our methodology. The data analysis done in this article is for illustration of our proposed method and can be applied to any situation that our model can be used.
Modelling perceptual characteristics of prototype headphones
Volk, Christer Peter; Pedersen, Torben Holm; Bech, Søren
2016-01-01
This study tested a framework for modelling of sensory descriptors (words) differentiating headphones. Six descriptors were included in a listening test with recordings of the sound reproductions of seven prototype headphones. A comprehensive data quality analysis investigated both the performanc...
2009-09-10
The Astrophysical Journal, 702:1553–1566, 2009 September 10 doi:10.1088/0004-637X/702/2/1553 C© 2009. The American Astronomical Society. All rights...to investigate a variety of high-energy processes in solar, space, and astrophysical plasmas. Key words: acceleration of particles – hydrodynamics...and can be viewed as an elementary process of sequential excitation of multiple loops. Evolution on longer timescales (say, !100 s) involves multiple
A single-source photon source model of a linear accelerator for Monte Carlo dose calculation.
Nwankwo, Obioma; Glatting, Gerhard; Wenz, Frederik; Fleckenstein, Jens
2017-01-01
To introduce a new method of deriving a virtual source model (VSM) of a linear accelerator photon beam from a phase space file (PSF) for Monte Carlo (MC) dose calculation. A PSF of a 6 MV photon beam was generated by simulating the interactions of primary electrons with the relevant geometries of a Synergy linear accelerator (Elekta AB, Stockholm, Sweden) and recording the particles that reach a plane 16 cm downstream the electron source. Probability distribution functions (PDFs) for particle positions and energies were derived from the analysis of the PSF. These PDFs were implemented in the VSM using inverse transform sampling. To model particle directions, the phase space plane was divided into a regular square grid. Each element of the grid corresponds to an area of 1 mm2 in the phase space plane. The average direction cosines, Pearson correlation coefficient (PCC) between photon energies and their direction cosines, as well as the PCC between the direction cosines were calculated for each grid element. Weighted polynomial surfaces were then fitted to these 2D data. The weights are used to correct for heteroscedasticity across the phase space bins. The directions of the particles created by the VSM were calculated from these fitted functions. The VSM was validated against the PSF by comparing the doses calculated by the two methods for different square field sizes. The comparisons were performed with profile and gamma analyses. The doses calculated with the PSF and VSM agree to within 3% /1 mm (>95% pixel pass rate) for the evaluated fields. A new method of deriving a virtual photon source model of a linear accelerator from a PSF file for MC dose calculation was developed. Validation results show that the doses calculated with the VSM and the PSF agree to within 3% /1 mm.
Rehydration characteristics and modeling of cassava chips
Ajala, A.S
2015-05-01
Full Text Available Cassava chips with dimension 4x2x0.2cm were re-hydrated in distilled water at 200C, 300C and 400C in a laboratory water bath. Kinetics of re-hydration was investigated using three different re-hydration models namely Peleg, exponential and Weibull. The pattern of water absorption was observed to be faster at the initial period of soaking. Higher temperature induces faster moisture absorption in the chips. Non linear regression analysis was used to fit in the experimental data and the coefficient of determination was found to be greater than 0.72 for all the models. The values of R2 , RMSE, MBE and reduced chi square showed that Weibull model best described the re-hydrating behaviour of the cassava chips.
Modeling laser-driven electron acceleration using WARP with Fourier decomposition
Lee, P., E-mail: patrick.lee@u-psud.fr [LPGP, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay (France); Audet, T.L. [LPGP, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay (France); Lehe, R.; Vay, J.-L. [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Maynard, G.; Cros, B. [LPGP, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay (France)
2016-09-01
WARP is used with the recent implementation of the Fourier decomposition algorithm to model laser-driven electron acceleration in plasmas. Simulations were carried out to analyze the experimental results obtained on ionization-induced injection in a gas cell. The simulated results are in good agreement with the experimental ones, confirming the ability of the code to take into account the physics of electron injection and reduce calculation time. We present a detailed analysis of the laser propagation, the plasma wave generation and the electron beam dynamics.
Matti, Afnan A; Mirzaei, Joseph; Rudolph, John; Smith, Stephen A; Newell, Jayme L; Patel, Sarjubhai A; Braden, Michael R; Bridges, Richard J; Natale, Nicholas R
2013-11-01
Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.
Characteristic Analysis of Fire Modeling Codes
Lee, Yoon Hwan; Yang, Joon Eon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Jong Hoon [Kyeongmin College, Ujeongbu (Korea, Republic of)
2004-04-15
This report documents and compares key features of four zone models: CFAST, COMPBRN IIIE, MAGIC and the Fire Induced Vulnerability Evaluation (FIVE) methodology. CFAST and MAGIC handle multi-compartment, multi-fire problems, using many equations; COMPBRN and FIVE handle single compartment, single fire source problems, using simpler equation. The increased rigor of the formulation of CFAST and MAGIC does not mean that these codes are more accurate in every domain; for instance, the FIVE methodology uses a single zone approximation with a plume/ceiling jet sublayer, while the other models use a two-zone treatment without a plume/ceiling jet sublayer. Comparisons with enclosure fire data indicate that inclusion of plume/ceiling jet sublayer temperatures is more conservative, and generally more accurate than neglecting them. Adding a plume/ceiling jet sublayer to the two-zone models should be relatively straightforward, but it has not been done yet for any of the two-zone models. Such an improvement is in progress for MAGIC.
FIRE CHARACTERISTICS FOR ADVANCED MODELLING OF FIRES
Otto Dvořák
2016-07-01
Full Text Available This paper summarizes the material and fire properties of solid flammable/combustible materials /substances /products, which are used as inputs for the computer numerical fire models. At the same time it gives the test standards for their determination.
A minimalist model of characteristic earthquakes
Vázquez-Prada, M.; González, Á.; Gómez, J.B.
2002-01-01
-earthquake behaviour of some seismic faults. This model, that has no parameter, is amenable to an algebraic description as a Markov Chain. This possibility illuminates some important results, obtained by Monte Carlo simulations, such as the earthquake size-frequency relation and the recurrence time...
Ren, Shijin
2004-01-01
Statistical models have long been used for reliability analysis and risk assessment. In the present study, an accelerated life-test model was used to analyze a set of dose-time-response data obtained with the terrestrial isopod Porcellio scaber. Survival data were experimentally obtained by exposing P. scaber to diazinon (a nonpersistent insecticide) at six concentrations between 2 and 11.31 microg/g (toxicant/soil). Survival data are presented on a weekly basis. The accelerated life-test model assumed a log-normal distribution and constant variance across all diazinon concentrations. Model parameters were obtained by maximum likelihood estimation. The accelerated life-test model was compared to a toxicokinetics-based model reported in the literature. Survival predictions made by both models were compared with the observed data. Both the accelerated life-test model and the toxicokinetics-based model underestimated toxicity at a diazinon concentration of 8 microg/g. Overall, however, the accelerated life-test model outperformed the toxicokinetics-based model, with survival predictions closer to the observed data in most cases and a stronger correlation between predicted and observed survivals. However, as a statistical model, the accelerated life-test model did not reveal mechanistic information, and only statistical and distributional interpretations of its model parameters could be made.
Jalas, S.; Dornmair, I.; Lehe, R.; Vincenti, H.; Vay, J.-L.; Kirchen, M.; Maier, A. R.
2017-03-01
Particle in Cell (PIC) simulations are a widely used tool for the investigation of both laser- and beam-driven plasma acceleration. It is a known issue that the beam quality can be artificially degraded by numerical Cherenkov radiation (NCR) resulting primarily from an incorrectly modeled dispersion relation. Pseudo-spectral solvers featuring infinite order stencils can strongly reduce NCR—or even suppress it—and are therefore well suited to correctly model the beam properties. For efficient parallelization of the PIC algorithm, however, localized solvers are inevitable. Arbitrary order pseudo-spectral methods provide this needed locality. Yet, these methods can again be prone to NCR. Here, we show that acceptably low solver orders are sufficient to correctly model the physics of interest, while allowing for parallel computation by domain decomposition.
Jalas, Sören; Lehe, Rémi; Vincenti, Henri; Vay, Jean-Luc; Kirchen, Manuel; Maier, Andreas R
2016-01-01
Particle in Cell (PIC) simulations are a widely used tool for the investigation of both laser- and beam-driven plasma acceleration. It is a known issue that the beam quality can be artificially degraded by numerical Cherenkov radiation (NCR) resulting primarily from an incorrectly modeled dispersion relation. Pseudo-spectral solvers featuring infinite order stencils can strongly reduce NCR -- or even suppress it -- and are therefore well suited to correctly model the beam properties. For efficient parallelization of the PIC algorithm, however, localized solvers are inevitable. Arbitrary order pseudo-spectral methods provide this needed locality. Yet, these methods can again be prone to NCR. Here, we show that acceptably low solver orders are sufficient to correctly model the physics of interest, while allowing for efficient parallelization.
Li, Qi-Lang; Wong, S. C.; Min, Jie; Tian, Shuo; Wang, Bing-Hong
2016-08-01
This study examines the cellular automata traffic flow model, which considers the heterogeneity of vehicle acceleration and the delay probability of vehicles. Computer simulations are used to identify three typical phases in the model: free-flow, synchronized flow, and wide moving traffic jam. In the synchronized flow region of the fundamental diagram, the low and high velocity vehicles compete with each other and play an important role in the evolution of the system. The analysis shows that there are two types of bistable phases. However, in the original Nagel and Schreckenberg cellular automata traffic model, there are only two kinds of traffic conditions, namely, free-flow and traffic jams. The synchronized flow phase and bistable phase have not been found.
Wake characteristics of a model ornithopter
Juarez, Alfredo; Harlow, Jacob; Allen, James; Ferreira de Sousa, Paulo
2006-03-01
This paper details unsteady wake measurements from a model Ornithopther flying in a wind tunnel at representative flight conditions. Testing over a range of Strouhal number, 0.1-0.3, shows that the unsteady wake is composed of coherent vortical structures that resemble vortex rings. A single ring is formed in the wake of each wing during one wing beat. Momentum balance from velocity field measurements are reconciled with unsteady lift and drag measurements from a drag balance.
Generalized accelerated failure time spatial frailty model for arbitrarily censored data.
Zhou, Haiming; Hanson, Timothy; Zhang, Jiajia
2016-03-18
Flexible incorporation of both geographical patterning and risk effects in cancer survival models is becoming increasingly important, due in part to the recent availability of large cancer registries. Most spatial survival models stochastically order survival curves from different subpopulations. However, it is common for survival curves from two subpopulations to cross in epidemiological cancer studies and thus interpretable standard survival models can not be used without some modification. Common fixes are the inclusion of time-varying regression effects in the proportional hazards model or fully nonparametric modeling, either of which destroys any easy interpretability from the fitted model. To address this issue, we develop a generalized accelerated failure time model which allows stratification on continuous or categorical covariates, as well as providing per-variable tests for whether stratification is necessary via novel approximate Bayes factors. The model is interpretable in terms of how median survival changes and is able to capture crossing survival curves in the presence of spatial correlation. A detailed Markov chain Monte Carlo algorithm is presented for posterior inference and a freely available function frailtyGAFT is provided to fit the model in the R package spBayesSurv. We apply our approach to a subset of the prostate cancer data gathered for Louisiana by the surveillance, epidemiology, and end results program of the National Cancer Institute.
Thin-Layer Drying Characteristics and Modeling of Chinese Jujubes
Xiao-Kang Yi
2012-01-01
Full Text Available A mathematical modeling of thin-layer drying of jujubes in a convective dryer was established under controlled conditions of temperature and velocity. The drying process took place both in the accelerating rate and falling rate period. We observed that higher temperature reduced the drying time, indicating higher drying rates of jujubes. The experimental drying data of jujubes were used to fit ten different thin-layer models, then drying rate constants and coefficients of models tested were determined by nonlinear regression analysis using the Statistical Computer Program. As for all the drying models, the Weibull distribution model was superior and best predicted the experimental values. Therefore, this model can be used to facilitate dryer design and promote efficient dryer operation by simulation and optimization of the drying processes. The volumetric shrinkable coefficient of jujubes decreased as the drying air temperature increased.
Accelerating dark energy models with anisotropic fluid in Bianchi type Ⅵ0 space-time
Anirudh Pradhan
2013-01-01
Motivated by the increasing evidence for the need of a geometry that resembles Bianchi morphology to explain the observed anisotropy in the WMAP data,we have discussed some features of Bianchi type Ⅵ0 universes in the presence of a fluid that has an anisotropic equation of state (EoS) parameter in general relativity.We present two accelerating dark energy (DE) models with an anisotropic fluid in Bianchi type Ⅵ0 space-time.To ensure a deterministic solution,we choose the scale factor a(t) =(√tnet),which yields a time-dependent deceleration parameter,representing a class of models which generate a transition of the universe from the early decelerating phase to the recent accelerating phase.Under suitable conditions,the anisotropic models approach an isotropic scenario.The EoS for DE ω is found to be time-dependent and its existing range for derived models is in good agreement with data from recent observations of type Ⅰa supernovae (SNe Ⅰa) (Knop et al.2003),SNe Ⅰa data combined with cosmic microwave background (CMB) anisotropy and galaxy clustering statistics (Tegmark et al.2004a),as well as the latest combination of cosmological datasets coming from CMB anisotropies,luminosity distances of high redshift SNe Ⅰa and galaxy clustering.For different values of n,we can generate a class of physically viable DE models.The cosmological constant Λ is found to be a positive decreasing function of time and it approaches a small positive value at late time (i.e.the present epoch),which is corroborated by results from recent SN Ⅰa observations.We also observe that our solutions are stable.The physical and geometric aspects of both models are also discussed in detail.
Lee, Shiu-Hang; Kamae, Tuneyoshi; Ellison, Donald C.
2008-07-02
We present a 3-dimensional model of supernova remnants (SNRs) where the hydrodynamical evolution of the remnant is modeled consistently with nonlinear diffusive shock acceleration occurring at the outer blast wave. The model includes particle escape and diffusion outside of the forward shock, and particle interactions with arbitrary distributions of external ambient material, such as molecular clouds. We include synchrotron emission and cooling, bremsstrahlung radiation, neutral pion production, inverse-Compton (IC), and Coulomb energy-loss. Boardband spectra have been calculated for typical parameters including dense regions of gas external to a 1000 year old SNR. In this paper, we describe the details of our model but do not attempt a detailed fit to any specific remnant. We also do not include magnetic field amplification (MFA), even though this effect may be important in some young remnants. In this first presentation of the model we don't attempt a detailed fit to any specific remnant. Our aim is to develop a flexible platform, which can be generalized to include effects such as MFA, and which can be easily adapted to various SNR environments, including Type Ia SNRs, which explode in a constant density medium, and Type II SNRs, which explode in a pre-supernova wind. When applied to a specific SNR, our model will predict cosmic-ray spectra and multi-wavelength morphology in projected images for instruments with varying spatial and spectral resolutions. We show examples of these spectra and images and emphasize the importance of measurements in the hard X-ray, GeV, and TeV gamma-ray bands for investigating key ingredients in the acceleration mechanism, and for deducing whether or not TeV emission is produced by IC from electrons or pion-decay from protons.
Model calibration criteria for estimating ecological flow characteristics
Vis, Marc; Knight, Rodney; Poole, Sandra; Wolfe, William; Seibert, Jan; Breuer, Lutz; Kraft, Philipp
2016-01-01
Quantification of streamflow characteristics in ungauged catchments remains a challenge. Hydrological modeling is often used to derive flow time series and to calculate streamflow characteristics for subsequent applications that may differ from those envisioned by the modelers. While the estimation of model parameters for ungauged catchments is a challenging research task in itself, it is important to evaluate whether simulated time series preserve critical aspects of the streamflow hydrograph. To address this question, seven calibration objective functions were evaluated for their ability to preserve ecologically relevant streamflow characteristics of the average annual hydrograph using a runoff model, HBV-light, at 27 catchments in the southeastern United States. Calibration trials were repeated 100 times to reduce parameter uncertainty effects on the results, and 12 ecological flow characteristics were computed for comparison. Our results showed that the most suitable calibration strategy varied according to streamflow characteristic. Combined objective functions generally gave the best results, though a clear underprediction bias was observed. The occurrence of low prediction errors for certain combinations of objective function and flow characteristic suggests that (1) incorporating multiple ecological flow characteristics into a single objective function would increase model accuracy, potentially benefitting decision-making processes; and (2) there may be a need to have different objective functions available to address specific applications of the predicted time series.
Advanced modelling of optoelectronic characteristics of OLEDs
Nitsche, Robert; Kurpiers-Guenther, Matthias [sim4tec GmbH, Schoenfelder Landstr. 8, 01328 Dresden (Germany); Thomschke, Michael; Schober, Matthias; Leo, Karl [Insitut fuer Angewandte Photophysik, TU Dresden, George-Baehr-Str. 1, 01069 Dresden (Germany)
2008-07-01
A rapid development of highly efficient OLED devices could be observed during the last years. The main work was carried out using experimental trial and error methods which are cost intensive and time consuming. A better approach is to conduct numerical simulations for device design and optimization beforehand, thus reducing the experimental work significantly and gaining a deep understanding of the underlying device physics. Here, we report on simulation results of multilayer single carrier devices and multilayer fluorescent and phosphorescent OLEDs including doped transport and emitter layers, using the integral OLED device simulator SimOLED. We first give an overview on optical and electrical modelling of OLEDs and discuss methodologies to obtain correct input parameters from fitting experimental results. Special focus is paid to the ambiguity of the extracted parameters to be used for further device modelling. The simulation results are compared to experimental data and conclusions are drawn concerning the distribution of electric field, recombination rates and exciton densities as well as charge carrier balance in the devices. Finally, we propose a generalized scheme for performing OLED simulations with predictive character.
Kim, Hyung Joon [School of Mechanical and Aerospace Engineering, Seoul National University, Gwanak-gu, Seoul 151-744 (Korea, Republic of); Kim, Kyung Hoon, E-mail: kimkh@khu.ac.kr [Department of Mechanical Engineering, Kyung Hee University, Seochun 1, Yongin, Gyeonggi 446-701 (Korea, Republic of)
2016-05-15
Highlights: • Wall-thinning erosion of pipelines in plants leads to fatal accidents unexpectedly. • Flow Acceleration Corrosion (FAC) is a main reason of wall-thinning. • For industrial safety, it is necessary to verify the tendency of FAC. • We focused on local wall thinning by FAC with intuitional visualization experiment and numerical analysis in elbow pipe.
A non-hydrodynamical model for acceleration of line-driven winds in Active Galactic Nuclei
Risaliti, G
2009-01-01
We present a study of the acceleration phase of line-driven winds in AGNs, in order to examine the physical conditions for the existence of such winds for a wide variety of initial conditions. We built a simple and fast non-hydrodynamic model, QWIND, where we assume that a wind is launched from the accretion disc at supersonic velocities of the order of a few 10^2 km/s and we concentrate on the subsequent supersonic phase. We show that this model can produce a wind with terminal velocities of the order of 10^4 km/s. There are three zones in the wind, only the middle one of which can launch a wind: in the inner zone the wind is too ionized and so experiences only the Compton radiation force which is not effective in accelerating gas. This inner failed wind however plays an important role in shielding the next zone, lowering the ionization parameter there. In the middle zone the lower ionization of the gas leads to a much larger radiation force and the gas achieves escape velocity This middle zone is quite thin...
Völlinger, C
2002-01-01
Superconducting magnets are obligatory today in order to provide the high magnetic fields that are needed for the acceleration of heavy particles in particle accelerators. The coils of such magnets are made of type II superconducting material and are exposed to a changing magnetic field which induces a so-called persistent current. Persistent currents are bipolar screening currents that do not decay, but persist due to the lack of resistivity in the superconductor. This way, they are the source of a superconductor magnetization in the coil which disturbs the field quality in the magnet aperture. In the framework of this thesis, a macroscopic superconductor model for the calculation of the magnetization of a thin superconducting cylinder of type II material has been developed. The model considers the dependency of the induced current density on the applied field as well as the local distribution of the magnetic induction within the superconductor. Both, the one-dimensional case of a homogeneous change of an ex...
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging.
Patterson, David; Cabelof, Diane C
2012-04-01
Down syndrome is a condition of intellectual disability characterized by accelerated aging. As with other aging syndromes, evidence accumulated over the past several decades points to a DNA repair defect inherent in Down syndrome. This evidence has led us to suggest that Down syndrome results in reduced DNA base excision repair (BER) capacity, and that this contributes to the genomic instability and the aging phenotype of Down syndrome. We propose important roles for microRNA and/or folate metabolism and oxidative stress in the dysregulation of BER in Down syndrome. Further, we suggest these pathways are involved in the leukemogenesis of Down syndrome. We have reviewed the role of BER in the processing of oxidative stress, and the impact of folate depletion on BER capacity. Further, we have reviewed the role that loss of BER, specifically DNA polymerase beta, plays in accelerating the rate of aging. Like that seen in the DNA polymerase beta heterozygous mouse, the aging phenotype of Down syndrome is subtle, unlike the aging phenotypes seen in the classical progeroid syndromes and mouse models of aging. As such, Down syndrome may provide a model for elucidating some of the basic mechanisms of aging.
High Tc Superconductor Theoretical Models and Electromagnetic Flux Characteristics
JIN Jian-xun
2006-01-01
High Tc Superconductors (HTS) have special electromagnetic characteristics and phenomena. Effort has been made in order to theoretically understand the applied HTS superconductivity and HTS behaviors for practical applications, various theoretical models related to the HTS electromagnetic properties have been developed. The theoretical models and analytic methods are summarized with regard to understanding the HTS magnetic flux characteristic which is one of the most critical issues related to HTS applications such as for HTS magnetic levitation application.
Dynamic inversion method based on the time-staggered stereo-modeling scheme and its acceleration
Jing, Hao; Yang, Dinghui; Wu, Hao
2016-12-01
A set of second-order differential equations describing the space-time behaviour of derivatives of displacement with respect to model parameters (i.e. waveform sensitivities) is obtained via taking the derivative of the original wave equations. The dynamic inversion method obtains sensitivities of the seismic displacement field with respect to earth properties directly by solving differential equations for them instead of constructing sensitivities from the displacement field itself. In this study, we have taken a new perspective on the dynamic inversion method and used acceleration approaches to reduce the computational time and memory usage to improve its ability of performing high-resolution imaging. The dynamic inversion method, which can simultaneously use different waves and multicomponent observation data, is appropriate for directly inverting elastic parameters, medium density or wave velocities. Full wavefield information is utilized as much as possible at the expense of a larger amount of calculations. To mitigate the computational burden, two ways are proposed to accelerate the method from a computer-implementation point of view. One is source encoding which uses a linear combination of all shots, and the other is to reduce the amount of calculations on forward modeling. We applied a new finite-difference (FD) method to the dynamic inversion to improve the computational accuracy and speed up the performance. Numerical experiments indicated that the new FD method can effectively suppress the numerical dispersion caused by the discretization of wave equations, resulting in enhanced computational efficiency with less memory cost for seismic modeling and inversion based on the full wave equations. We present some inversion results to demonstrate the validity of this method through both checkerboard and Marmousi models. It shows that this method is also convergent even with big deviations for the initial model. Besides, parallel calculations can be easily
Intelligent control based on intelligent characteristic model and its application
吴宏鑫; 王迎春; 邢琰
2003-01-01
This paper presents a new intelligent control method based on intelligent characteristic model for a kind of complicated plant with nonlinearities and uncertainties, whose controlled output variables cannot be measured on line continuously. The basic idea of this method is to utilize intelligent techniques to form the characteristic model of the controlled plant according to the principle of combining the char-acteristics of the plant with the control requirements, and then to present a new design method of intelli-gent controller based on this characteristic model. First, the modeling principles and expression of the intelligent characteristic model are presented. Then based on description of the intelligent characteristic model, the design principles and methods of the intelligent controller composed of several open-loops and closed-loops sub controllers with qualitative and quantitative information are given. Finally, the ap-plication of this method in alumina concentration control in the real aluminum electrolytic process is in-troduced. It is proved in practice that the above methods not only are easy to implement in engineering design but also avoid the trial-and-error of general intelligent controllers. It has taken better effect in the following application: achieving long-term stable control of low alumina concentration and increasing the controlled ratio of anode effect greatly from 60% to 80%.
Rate equation modelling and investigation of quantum cascade detector characteristics
Saha, Sumit; Kumar, Jitendra
2016-10-01
A simple precise transport model has been proposed using rate equation approach for the characterization of a quantum cascade detector. The resonant tunneling transport is incorporated in the rate equation model through a resonant tunneling current density term. All the major scattering processes are included in the rate equation model. The effect of temperature on the quantum cascade detector characteristics has been examined considering the temperature dependent band parameters and the carrier scattering processes. Incorporation of the resonant tunneling process in the rate equation model improves the detector performance appreciably and reproduces the detector characteristics within experimental accuracy.
Lyu, Jingyuan; Nakarmi, Ukash; Zhang, Chaoyi; Ying, Leslie
2016-05-01
This paper presents a new approach to highly accelerated dynamic parallel MRI using low rank matrix completion, partial separability (PS) model. In data acquisition, k-space data is moderately randomly undersampled at the center kspace navigator locations, but highly undersampled at the outer k-space for each temporal frame. In reconstruction, the navigator data is reconstructed from undersampled data using structured low-rank matrix completion. After all the unacquired navigator data is estimated, the partial separable model is used to obtain partial k-t data. Then the parallel imaging method is used to acquire the entire dynamic image series from highly undersampled data. The proposed method has shown to achieve high quality reconstructions with reduction factors up to 31, and temporal resolution of 29ms, when the conventional PS method fails.
Late time acceleration in a non-commutative model of modified cosmology
Malekolkalami, B., E-mail: b.malakolkalami@uok.ac.ir [Department of Physics, University of Kurdistan, Pasdaran St., Sanandaj (Iran, Islamic Republic of); Atazadeh, K., E-mail: atazadeh@azaruniv.ac.ir [Department of Physics, Azarbaijan Shahid Madani University, 53714-161, Tabriz (Iran, Islamic Republic of); Vakili, B., E-mail: b-vakili@iauc.ac.ir [Department of Physics, Central Tehran Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of)
2014-12-12
We investigate the effects of non-commutativity between the position–position, position–momentum and momentum–momentum of a phase space corresponding to a modified cosmological model. We show that the existence of such non-commutativity results in a Moyal Poisson algebra between the phase space variables in which the product law between the functions is of the kind of an α-deformed product. We then transform the variables in such a way that the Poisson brackets between the dynamical variables take the form of a usual Poisson bracket but this time with a noncommutative structure. For a power law expression for the function of the Ricci scalar with which the action of the gravity model is modified, the exact solutions in the commutative and noncommutative cases are presented and compared. In terms of these solutions we address the issue of the late time acceleration in cosmic evolution.
Lee, Shiu-Hang; Nagataki, Shigehiro
2012-01-01
To better model the efficient production of cosmic rays (CRs) in supernova remnants (SNRs) with the associated coupling between CR production and SNR dynamics, we have generalized an existing cr-hydro-NEI code (i.e., Ellison et al. 2012) to include the following processes: (1) an explicit calculation of the upstream precursor structure including the position dependent flow speed, density, temperature, and magnetic field strength; (2) a momentum and space dependent CR diffusion coefficient; (3) an explicit calculation of magnetic field amplification (MFA); (4) calculation of the maximum CR momentum using the amplified magnetic field; (5) a finite Alfven speed for the particle scattering centers; and (6) the ability to accelerate a superthermal seed population of CRs as well as the ambient thermal plasma. While a great deal of work has been done modeling SNRs, most work has concentrated on either the continuum emission from relativistic electrons or ions, or the thermal emission from the shock heated plasma. Ou...
Late time acceleration in a non-commutative model of modified cosmology
Malekolkalami, B.; Atazadeh, K.; Vakili, B.
2014-12-01
We investigate the effects of non-commutativity between the position-position, position-momentum and momentum-momentum of a phase space corresponding to a modified cosmological model. We show that the existence of such non-commutativity results in a Moyal Poisson algebra between the phase space variables in which the product law between the functions is of the kind of an α-deformed product. We then transform the variables in such a way that the Poisson brackets between the dynamical variables take the form of a usual Poisson bracket but this time with a noncommutative structure. For a power law expression for the function of the Ricci scalar with which the action of the gravity model is modified, the exact solutions in the commutative and noncommutative cases are presented and compared. In terms of these solutions we address the issue of the late time acceleration in cosmic evolution.
Late time acceleration in a non-commutative model of modified cosmology
Malekolkalami, B; Vakili, B
2014-01-01
We investigate the effects of noncommutativity between the position-position, position-momentum and momentum-momentum of a phase space corresponding to a modified cosmological model. We show that the existence of such noncommutativity results in a Moyal Poisson algebra between the phase space variables in which the product law between the functions is of the kind of a $\\alpha$-deformed product. We then transform the variables in such a way that the Poisson brackets between the dynamical variables takes the form of a usual Poisson bracket but this time with a noncommutative structure. For a power law expression for the function of the Ricci scalar with which the action of the gravity model is modified, the exact solutions in the commutative and noncommutative cases are presented and compared. In terms of these solutions we address the issue of the late time acceleration in cosmic evolution.
Late time acceleration in a non-commutative model of modified cosmology
B. Malekolkalami
2014-12-01
Full Text Available We investigate the effects of non-commutativity between the position–position, position–momentum and momentum–momentum of a phase space corresponding to a modified cosmological model. We show that the existence of such non-commutativity results in a Moyal Poisson algebra between the phase space variables in which the product law between the functions is of the kind of an α-deformed product. We then transform the variables in such a way that the Poisson brackets between the dynamical variables take the form of a usual Poisson bracket but this time with a noncommutative structure. For a power law expression for the function of the Ricci scalar with which the action of the gravity model is modified, the exact solutions in the commutative and noncommutative cases are presented and compared. In terms of these solutions we address the issue of the late time acceleration in cosmic evolution.
Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging.
Forman, Katherine; Vara, Elena; García, Cruz; Kireev, Roman; Cuesta, Sara; Acuña-Castroviejo, Darío; Tresguerres, J A F
2010-10-01
This study investigated the effect of aging-related parameters such as inflammation, oxidative stress and cell death in the heart in an animal model of accelerated senescence and analyzed the effects of chronic administration of melatonin on these markers. Thirty male mice of senescence-accelerated prone (SAMP8) and 30 senescence-accelerated-resistant mice (SAMR1) at 2 and 10 months of age were used. Animals were divided into eight experimental groups, four from each strain: two young control groups, two old untreated control groups, and four melatonin-treated groups. Melatonin was provided at two different dosages (1 and 10 mg/kg/day) in the drinking water. After 30 days of treatment, the expression of inflammatory mediators (tumor necrosis factor-alpha, interleukin 1 and 10, NFkBp50 and NFkBp52), apoptosis markers (BAD, BAX and Bcl2) and parameters related to oxidative stress (heme oxygenases 1 and 2, endothelial and inducible nitric oxide synthases) were determined in the heart by real-time reverse transcription polymerase chain reaction (RT-PCR). Inflammation, as well as, oxidative stress and apoptosis markers was increased in old SAMP8 males, when compared to its young controls. SAMR1 mice showed significantly lower basal levels of the measured parameters and smaller increases with age or no increases at all. After treatment with melatonin, these age-altered parameters were partially reversed, especially in SAMP8 mice. The results suggest that oxidative stress and inflammation increase with aging and that chronic treatment with melatonin, a potent antioxidant, reduces these parameters. The effects were more marked in the SAMP8 animals. © 2010 The Authors. Journal of Pineal Research © 2010 John Wiley & Sons A/S.
Tchabo, William; Ma, Yongkun; Kwaw, Emmanuel; Zhang, Haining; Xiao, Lulu; Tahir, Haroon Elrasheid
2017-10-01
The present study was undertaken to assess accelerating aging effects of high pressure, ultrasound and manosonication on the aromatic profile and sensorial attributes of aged mulberry wines (AMW). A total of 166 volatile compounds were found amongst the AMW. The outcomes of the investigation were presented by means of geometric mean (GM), cluster analysis (CA), principal component analysis (PCA), partial least squares regressions (PLSR) and principal component regression (PCR). GM highlighted 24 organoleptic attributes responsible for the sensorial profile of the AMW. Moreover, CA revealed that the volatile composition of the non-thermal accelerated aged wines differs from that of the conventional aged wines. Besides, PCA discriminated the AMW on the basis of their main sensorial characteristics. Furthermore, PLSR identified 75 aroma compounds which were mainly responsible for the olfactory notes of the AMW. Finally, the overall quality of the AMW was noted to be better predicted by PLSR than PCR. Copyright © 2017 Elsevier Ltd. All rights reserved.
da Costa, Fatima Rubio; Petrosian, Vahe'; Carlsson, Mats
2015-01-01
Solar flares involve complex processes that are coupled together and span a wide range of temporal, spatial, and energy scales. Modeling such processes self-consistently has been a challenge in the past. Here we present such a model to simulate the coupling of high-energy particle kinetics with hydrodynamics of the atmospheric plasma. We combine the Stanford unified Fokker-Planck code that models particle acceleration, transport, and bremsstrahlung radiation with the RADYN hydrodynamic code that models the atmospheric response to collisional heating by non-thermal electrons through detailed radiative transfer calculations. We perform simulations using different injection electron spectra, including an {\\it ad hoc} power law and more realistic spectra predicted by the stochastic acceleration model due to turbulence or plasma waves. Surprisingly, stochastically accelerated electrons, even with energy flux $\\ll 10^{10}$ erg s$^{-1}$ cm$^{-2}$, cause "explosive" chromospheric evaporation and drive stronger up- an...
MODELING OF FUEL SPRAY CHARACTERISTICS AND DIESEL COMBUSTION CHAMBER PARAMETERS
G. M. Kukharonak
2011-01-01
Full Text Available The computer model for coordination of fuel spray characteristics with diesel combustion chamber parameters has been created in the paper. The model allows to observe fuel sprays develоpment in diesel cylinder at any moment of injection, to calculate characteristics of fuel sprays with due account of a shape and dimensions of a combustion chamber, timely to change fuel injection characteristics and supercharging parameters, shape and dimensions of a combustion chamber. Moreover the computer model permits to determine parameters of holes in an injector nozzle that provides the required fuel sprays characteristics at the stage of designing a diesel engine. Combustion chamber parameters for 4ЧН11/12.5 diesel engine have been determined in the paper.
Georgiou, Marina; Daglis, Ioannis; Zesta, Eftyhia; Sibeck, David; Fok, Mei-ching; Balasis, Georgios; Mann, Ian; Tsinganos, Kanaris
2017-04-01
Periodic oscillations in the Earth's magnetic field with frequencies in the range of a few mHz (ULF waves) can influence radiation belt dynamics due to their potential for strong interactions with charged particles and in particular, relativistic electrons. We have explored possible relationships between the spatial and temporal profile of ULF wave power with relativistic electron fluxes as well as different solar wind parameters. We used data from multiple ground magnetometer arrays contributing to the worldwide SuperMAG collaboration to calculate the ULF wave power in the Pc5 frequency band (2 - 7 mHz) from for a total of 40 moderate and intense magnetic storms over the last solar cycle 23. During the main phase of both sets of storms, there is a marked penetration of Pc5 wave power to L-shells as low as 2-3. The penetration of ULF waves is deeper into the inner magnetosphere during intense magnetic storms characterised by enhanced post-storm electron fluxes. Furthermore, later in the recovery phase, enhanced Pc5 wave activity was found to persist longer for storms marked by electron-enhanced storms flux enhancement than for those that do not produce such electron flux enhancements. Growth and decay characteristics of Pc5 waves were explored in association with the plasmapause location, determined from IMAGE EUV observations. Pc5 wave power enhancements and relativistic electron acceleration were not only intimately linked, but also restricted beyond the plasmapause. These observations provided the basis for a superposed epoch analysis, the results of which are compared to predictions from the Comprehensive Inner Magnetosphere-Ionosphere (CIMI) model. These simulations are critical for understanding the extent to which ULF wave electric fields are responsible for the observed electron acceleration and for examining the nature of mechanisms responsible for driving such large-amplitude ULF waves in the magnetosphere. This work has been supported by the NOA
LIM; C.W.
2010-01-01
Nonlinear combination parametric resonance is investigated for an axially accelerating viscoelastic string.The governing equation of in-planar motion of the string is established by introducing a coordinate transform in the Eulerian equation of a string with moving boundaries.The string under investigation is constituted by the standard linear solid model in which the material,not partial,time derivative was used.The governing equation leads to the Mote model for transverse vibration by omitting the longitudinal component and higher order terms.The Kirchhoff model is derived from the Mote model by replacing the tension with the averaged tension over the string.The two models are respectively analyzed via the method of multiple scales for principal parametric resonance.The amplitudes and the existence conditions of steady-state response and its stability can be numerically determined.Numerical calculations demonstrate the effects of the string material parameters,the initial tension,and the axial speed fluctuation amplitude.The outcomes of the two models are qualitatively and quantitatively compared.
Accelerated Electromechanical Modeling of a Distributed Internal Combustion Engine Generator Unit
Serhiy V. Bozhko
2012-07-01
Full Text Available Distributed generation with a combustion engine prime mover is still widely used to supply electric power in a variety of applications. These applications range from backup power supply systems and combined wind-diesel generation to providing power in places where grid connection is either technically impractical or financially uneconomic. Modelling of such systems as a whole is extremely difficult due to the long-time load profiles needed and the computational difficulty of including small time-constant electrical dynamics with large time-constant mechanical dynamics. This paper presents the development of accelerated, reduced-order models of a distributed internal combustions engine generator unit. Overall these models are shown to achieve a massive improvement in the computational time required for long-time simulations while also achieving an extremely high level of dynamic accuracy. It is demonstrated how these models are derived, used and verified against benchmark models created using established techniques. Throughout the paper the modelling set as a whole, including multi level detail, is presented, detailed and finally summarised into a crucial tool for general system investigation and multiple target optimisation.
Graphics Processing Unit (GPU) Acceleration of the Goddard Earth Observing System Atmospheric Model
Putnam, Williama
2011-01-01
The Goddard Earth Observing System 5 (GEOS-5) is the atmospheric model used by the Global Modeling and Assimilation Office (GMAO) for a variety of applications, from long-term climate prediction at relatively coarse resolution, to data assimilation and numerical weather prediction, to very high-resolution cloud-resolving simulations. GEOS-5 is being ported to a graphics processing unit (GPU) cluster at the NASA Center for Climate Simulation (NCCS). By utilizing GPU co-processor technology, we expect to increase the throughput of GEOS-5 by at least an order of magnitude, and accelerate the process of scientific exploration across all scales of global modeling, including: The large-scale, high-end application of non-hydrostatic, global, cloud-resolving modeling at 10- to I-kilometer (km) global resolutions Intermediate-resolution seasonal climate and weather prediction at 50- to 25-km on small clusters of GPUs Long-range, coarse-resolution climate modeling, enabled on a small box of GPUs for the individual researcher After being ported to the GPU cluster, the primary physics components and the dynamical core of GEOS-5 have demonstrated a potential speedup of 15-40 times over conventional processor cores. Performance improvements of this magnitude reduce the required scalability of 1-km, global, cloud-resolving models from an unfathomable 6 million cores to an attainable 200,000 GPU-enabled cores.
Physics-Based Fragment Acceleration Modeling for Pressurized Tank Burst Risk Assessments
Manning, Ted A.; Lawrence, Scott L.
2014-01-01
As part of comprehensive efforts to develop physics-based risk assessment techniques for space systems at NASA, coupled computational fluid and rigid body dynamic simulations were carried out to investigate the flow mechanisms that accelerate tank fragments in bursting pressurized vessels. Simulations of several configurations were compared to analyses based on the industry-standard Baker explosion model, and were used to formulate an improved version of the model. The standard model, which neglects an external fluid, was found to agree best with simulation results only in configurations where the internal-to-external pressure ratio is very high and fragment curvature is small. The improved model introduces terms that accommodate an external fluid and better account for variations based on circumferential fragment count. Physics-based analysis was critical in increasing the model's range of applicability. The improved tank burst model can be used to produce more accurate risk assessments of space vehicle failure modes that involve high-speed debris, such as exploding propellant tanks and bursting rocket engines.
Modelling the effect of the radiation reaction force on the acceleration of ultra-thin foils
Duff, M. J.; Capdessus, R.; King, M.; Del Sorbo, D.; Ridgers, C. P.; McKenna, P.
2017-05-01
An investigation of the effects of the radiation reaction force on radiation pressure acceleration is presented. Through 1D(3V) PIC code simulations, it is found that radiation reaction causes a decrease in the target velocity during the interaction of an ultra-intense laser pulse with a solid density thin foil of varying thickness. This change in the target velocity can be related to the loss of backwards-directed electrons due to cooling and reflection in the laser field. The loss of this electron population changes the distribution of the emitted synchrotron radiation. We demonstrate that it is the emission of radiation which leads to the observed decrease in target velocity. Through a modification to the light sail equation of motion (which is used to describe radiation pressure acceleration in thin foils), which accounts for the conversion of laser energy to synchrotron radiation, we can describe this change in target velocity. This model can be tested in future experiments with ultra-high intensity lasers, and will lead to a better understanding of the process of relativistically induced transparency in the new intensity regime.
Neoadjuvant paradigm for accelerated drug development: an ideal model in bladder cancer.
Chism, David D; Woods, Michael E; Milowsky, Matthew I
2013-01-01
Neoadjuvant cisplatin-based combination chemotherapy for muscle-invasive bladder cancer (MIBC) has been shown to confer a survival advantage in two randomized clinical trials and a meta-analysis. Despite level 1 evidence supporting its benefit, utilization remains dismal with nearly one-half of patients ineligible for cisplatin-based therapy because of renal dysfunction, impaired performance status, and/or coexisting medical problems. This situation highlights the need for the development of novel therapies for the management of MIBC, a disease with a lethal phenotype. The neoadjuvant paradigm in bladder cancer offers many advantages for accelerated drug development. First, there is a greater likelihood of successful therapy at an earlier disease state that may be characterized by less genomic instability compared with the metastatic setting, with an early readout of activity with results determined in months rather than years. Second, pre- and post-treatment tumor tissue collection in patients with MIBC is performed as the standard of care without the need for research-directed biopsies, allowing for the ability to perform important correlative studies and to monitor tumor response to therapy in "real time." Third, pathological complete response (pT0) predicts for improved outcome in patients with MIBC. Fourth, there is a strong biological rationale with rapidly accumulating evidence for actionable targets in bladder cancer. This review focuses on the neoadjuvant paradigm for accelerated drug development using bladder cancer as the ideal model.
Dongha Lim
2014-01-01
Full Text Available Falls are a serious medical and social problem among the elderly. This has led to the development of automatic fall-detection systems. To detect falls, a fall-detection algorithm that combines a simple threshold method and hidden Markov model (HMM using 3-axis acceleration is proposed. To apply the proposed fall-detection algorithm and detect falls, a wearable fall-detection device has been designed and produced. Several fall-feature parameters of 3-axis acceleration are introduced and applied to a simple threshold method. Possible falls are chosen through the simple threshold and are applied to two types of HMM to distinguish between a fall and an activity of daily living (ADL. The results using the simple threshold, HMM, and combination of the simple method and HMM were compared and analyzed. The combination of the simple threshold method and HMM reduced the complexity of the hardware and the proposed algorithm exhibited higher accuracy than that of the simple threshold method.
Accelerated search for biomolecular network models to interpret high-throughput experimental data
Sokhansanj Bahrad A
2007-07-01
Full Text Available Abstract Background The functions of human cells are carried out by biomolecular networks, which include proteins, genes, and regulatory sites within DNA that encode and control protein expression. Models of biomolecular network structure and dynamics can be inferred from high-throughput measurements of gene and protein expression. We build on our previously developed fuzzy logic method for bridging quantitative and qualitative biological data to address the challenges of noisy, low resolution high-throughput measurements, i.e., from gene expression microarrays. We employ an evolutionary search algorithm to accelerate the search for hypothetical fuzzy biomolecular network models consistent with a biological data set. We also develop a method to estimate the probability of a potential network model fitting a set of data by chance. The resulting metric provides an estimate of both model quality and dataset quality, identifying data that are too noisy to identify meaningful correlations between the measured variables. Results Optimal parameters for the evolutionary search were identified based on artificial data, and the algorithm showed scalable and consistent performance for as many as 150 variables. The method was tested on previously published human cell cycle gene expression microarray data sets. The evolutionary search method was found to converge to the results of exhaustive search. The randomized evolutionary search was able to converge on a set of similar best-fitting network models on different training data sets after 30 generations running 30 models per generation. Consistent results were found regardless of which of the published data sets were used to train or verify the quantitative predictions of the best-fitting models for cell cycle gene dynamics. Conclusion Our results demonstrate the capability of scalable evolutionary search for fuzzy network models to address the problem of inferring models based on complex, noisy biomolecular
Martínez-García, Cristina; Izquierdo, Adriana; Velagapudi, Vidya; Vivas, Yurena; Velasco, Ismael; Campbell, Mark; Burling, Keith; Cava, Fernando; Ros, Manuel; Oresic, Matej; Vidal-Puig, Antonio; Medina-Gomez, Gema
2012-09-01
Individuals with metabolic syndrome are at high risk of developing chronic kidney disease (CKD) through unclear pathogenic mechanisms. Obesity and diabetes are known to induce glucolipotoxic effects in metabolically relevant organs. However, the pathogenic role of glucolipotoxicity in the aetiology of diabetic nephropathy is debated. We generated a murine model, the POKO mouse, obtained by crossing the peroxisome proliferator-activated receptor gamma 2 (PPARγ2) knockout (KO) mouse into a genetically obese ob/ob background. We have previously shown that the POKO mice showed: hyperphagia, insulin resistance, hyperglycaemia and dyslipidaemia as early as 4 weeks of age, and developed a complete loss of normal β-cell function by 16 weeks of age. Metabolic phenotyping of the POKO model has led to investigation of the structural and functional changes in the kidney and changes in blood pressure in these mice. Here we demonstrate that the POKO mouse is a model of renal disease that is accelerated by high levels of glucose and lipid accumulation. Similar to ob/ob mice, at 4 weeks of age these animals exhibited an increased urinary albumin:creatinine ratio and significantly increased blood pressure, but in contrast showed a significant increase in the renal hypertrophy index and an associated increase in p27(Kip1) expression compared with their obese littermates. Moreover, at 4 weeks of age POKO mice showed insulin resistance, an alteration of lipid metabolism and glomeruli damage associated with increased transforming growth factor beta (TGFβ) and parathyroid hormone-related protein (PTHrP) expression. At this age, levels of proinflammatory molecules, such as monocyte chemoattractant protein-1 (MCP-1), and fibrotic factors were also increased at the glomerular level compared with levels in ob/ob mice. At 12 weeks of age, renal damage was fully established. These data suggest an accelerated lesion through glucolipotoxic effects in the renal pathogenesis in POKO mice.
Cristina Martínez-García
2012-09-01
Individuals with metabolic syndrome are at high risk of developing chronic kidney disease (CKD through unclear pathogenic mechanisms. Obesity and diabetes are known to induce glucolipotoxic effects in metabolically relevant organs. However, the pathogenic role of glucolipotoxicity in the aetiology of diabetic nephropathy is debated. We generated a murine model, the POKO mouse, obtained by crossing the peroxisome proliferator-activated receptor gamma 2 (PPARγ2 knockout (KO mouse into a genetically obese ob/ob background. We have previously shown that the POKO mice showed: hyperphagia, insulin resistance, hyperglycaemia and dyslipidaemia as early as 4 weeks of age, and developed a complete loss of normal β-cell function by 16 weeks of age. Metabolic phenotyping of the POKO model has led to investigation of the structural and functional changes in the kidney and changes in blood pressure in these mice. Here we demonstrate that the POKO mouse is a model of renal disease that is accelerated by high levels of glucose and lipid accumulation. Similar to ob/ob mice, at 4 weeks of age these animals exhibited an increased urinary albumin:creatinine ratio and significantly increased blood pressure, but in contrast showed a significant increase in the renal hypertrophy index and an associated increase in p27Kip1 expression compared with their obese littermates. Moreover, at 4 weeks of age POKO mice showed insulin resistance, an alteration of lipid metabolism and glomeruli damage associated with increased transforming growth factor beta (TGFβ and parathyroid hormone-related protein (PTHrP expression. At this age, levels of proinflammatory molecules, such as monocyte chemoattractant protein-1 (MCP-1, and fibrotic factors were also increased at the glomerular level compared with levels in ob/ob mice. At 12 weeks of age, renal damage was fully established. These data suggest an accelerated lesion through glucolipotoxic effects in the renal pathogenesis in POKO mice.
Late cosmic acceleration in a vector-Gauss-Bonnet gravity model
Oliveros, A.; Solis, Enzo L.; Acero, Mario A.
2016-12-01
In this work, we study a general vector-tensor model of dark energy (DE) with a Gauss-Bonnet term coupled to a vector field and without explicit potential terms. Considering a spatially flat Friedmann-Robertson-Walker (FRW) type universe and a vector field without spatial components, the cosmological evolution is analyzed from the field equations of this model considering two sets of parameters. In this context, we have shown that it is possible to obtain an accelerated expansion phase of the universe since the equation state parameter w satisfies the restriction - 1 < w < -1/3 (for suitable values of model parameters). Further, analytical expressions for the Hubble parameter H, equation state parameter w and the invariant scalar ϕ are obtained. We also find that the square of the speed of sound is negative for all values of redshift, therefore, the model presented here shows a sign of instability under small perturbations. We finally perform an analysis using H(z) observational data and we find that for the free parameter ξ in the interval (-23.9,-3.46) × 10-5, at 99.73% C.L. (and fixing η = -1 and ω = 1/4), the model has a good fit to the data.
Bengtsson, Sara K; Johansson, Maja; Backstrom, Torbjorn; Nitsch, Roger M; Wang, Mingde
2013-01-01
Previously, we have shown that chronic treatment with allopregnanolone (ALLO) for three months impaired learning function in the Swe/PS1 mouse model. ALLO is a neurosteroid, produced in the CNS and a GABAA receptor agonist. ALLO modulates the general inhibitory system in the CNS by enhancing the effect of GABA. Chronic treatment with other GABAA receptor active compounds, such as benzodiazepines, ethanol and medroxy-progesterone acetate has been associated to cognitive decline and/or increased risk for dementia. In this study, we sufficed with a treatment period of one month for the Swe/PS1 mouse, and included another Alzheimer's disease mouse model; the Swe/Arc model. We found that one month of chronic treatment with elevated ALLO levels within physiological range impaired learning and memory function in the Swe/Arc female and male mice. Male Swe/PS1 mice also showed marginally impaired function, while the female mice did not. Furthermore, the chronic ALLO treatment caused increased levels of soluble Aβ in the Swe/PS1 mouse model while the levels were unchanged in the Swe/Arc model. Therefore, both Swe/Arc and Swe/PS1 mice showed signs of accelerated disease progression. Still, further studies are required to determine the mechanisms behind the cognitive impairment and the increased Aβ-levels caused by mildly elevated ALLO-levels.
Characteristic earthquake model, 1884 -- 2011, R.I.P
Kagan, Yan Y; Geller, Robert J
2012-01-01
Unfortunately, working scientists sometimes reflexively continue to use "buzz phrases" grounded in once prevalent paradigms that have been subsequently refuted. This can impede both earthquake research and hazard mitigation. Well-worn seismological buzz phrases include "earthquake cycle," "seismic cycle," "seismic gap," and "characteristic earthquake." They all assume that there are sequences of earthquakes that are nearly identical except for the times of their occurrence. If so, the complex process of earthquake occurrence could be reduced to a description of one "characteristic" earthquake plus the times of the others in the sequence. A common additional assumption is that characteristic earthquakes dominate the displacement on fault or plate boundary "segments." The "seismic gap" (or the effectively equivalent "seismic cycle") model depends entirely on the "characteristic" assumption, with the added assumption that characteristic earthquakes are quasi-periodic. However, since the 1990s numerous statistica...
De Martino, S; Illuminati, F; Martino, Salvatore De; Siena, Silvio De; Illuminati, Fabrizio
1999-01-01
A recent proposal (see quant-ph/9803068) to simulate semiclassical corrections to classical dynamics by suitable classical stochastic fluctuations is applied to the specific instance of charged beam dynamics in particle accelerators. The resulting picture is that the collective beam dynamics, at the leading semiclassical order in Planck constant can be described by a particular diffusion process, the Nelson process, which is time-reversal invariant. Its diffusion coefficient $\\sqrt{N}\\lambda_{c}$ represents a semiclassical unit of emittance (here $N$ is the number of particles in the beam, and $\\lambda_{c}$ is the Compton wavelength). The stochastic dynamics of the Nelson type can be easily recast in the form of a Schroedinger equation, with the semiclassical unit of emittance replacing Planck constant. Therefore we provide a physical foundation to the several quantum-like models of beam dynamics proposed in recent years. We also briefly touch upon applications of the Nelson and Schroedinger formalisms to inc...
Accelerated lattice Boltzmann model for colloidal suspensions rheology and interface morphology
Farhat, Hassan; Kondaraju, Sasidhar
2014-01-01
Colloids are ubiquitous in the food, medical, cosmetics, polymers, water purification, and pharmaceutical industries. The thermal, mechanical, and storage properties of colloids are highly dependent on their interface morphology and their rheological behavior. Numerical methods provide a convenient and reliable tool for the study of colloids. Accelerated Lattice Boltzmann Model for Colloidal Suspensions introduce the main building-blocks for an improved lattice Boltzmann–based numerical tool designed for the study of colloidal rheology and interface morphology. This book also covers the migrating multi-block used to simulate single component, multi-component, multiphase, and single component multiphase flows and their validation by experimental, numerical, and analytical solutions. Among other topics discussed are the hybrid lattice Boltzmann method (LBM) for surfactant-covered droplets; biological suspensions such as blood; used in conjunction with the suppression of coalescence for investigating the...
Johnson, Lynn M; Strawderman, Robert L
2012-09-20
This paper proposes an estimation procedure for the semiparametric accelerated failure time frailty model that combines smoothing with an Expectation and Maximization-like algorithm for estimating equations. The resulting algorithm permits simultaneous estimation of the regression parameter, the baseline cumulative hazard, and the parameter indexing a general frailty distribution. We develop novel moment-based estimators for the frailty parameter, including a generalized method of moments estimator. Standard error estimates for all parameters are easily obtained using a randomly weighted bootstrap procedure. For the commonly used gamma frailty distribution, the proposed algorithm is very easy to implement using widely available numerical methods. Simulation results demonstrate that the algorithm performs very well in this setting. We re-analyz several previously analyzed data sets for illustrative purposes.
An Instability of the Standard Model Creates the Anomalous Acceleration Without Dark Energy
Smoller, Joel; Vogler, Zeke
2014-01-01
We introduce a new asymptotic ansatz for spherical perturbations of the Standard Model of Cosmology (SM) which applies during the $p=0$ epoch, and prove that these perturbations trigger instabilities in the SM on the scale of the supernova data. These instabilities create a large, central region of uniform under-density which expands faster than the SM, and this central region of accelerated uniform expansion introduces into the SM {\\it precisely} the same range of corrections to redshift vs luminosity as are produced by the cosmological constant in the theory of Dark Energy. A universal behavior is exhibited because all sufficiently small perturbations evolve to a single stable rest point. Moreover, we prove that these perturbations are consistent with, and the instability is triggered by, the one parameter family of self-similar waves which the authors previously proposed as possible time-asymptotic wave patterns for perturbations of the SM at the end of the radiation epoch. Using numerical simulations, we ...
Computationally efficient methods for modelling laser wakefield acceleration in the blowout regime
Cowan, B M; Beck, A; Davoine, X; Bunkers, K; Lifschitz, A F; Lefebvre, E; Bruhwiler, D L; Shadwick, B A; Umstadter, D P
2012-01-01
Electron self-injection and acceleration until dephasing in the blowout regime is studied for a set of initial conditions typical of recent experiments with 100 terawatt-class lasers. Two different approaches to computationally efficient, fully explicit, three-dimensional particle-in-cell modelling are examined. First, the Cartesian code VORPAL using a perfect-dispersion electromagnetic solver precisely describes the laser pulse and bubble dynamics, taking advantage of coarser resolution in the propagation direction, with a proportionally larger time step. Using third-order splines for macroparticles helps suppress the sampling noise while keeping the usage of computational resources modest. The second way to reduce the simulation load is using reduced-geometry codes. In our case, the quasi-cylindrical code CALDER-CIRC uses decomposition of fields and currents into a set of poloidal modes, while the macroparticles move in the Cartesian 3D space. Cylindrical symmetry of the interaction allows using just two mo...
Sukarno; Haryati, Sri
2015-01-01
This article reports Year One of a two-year study to develop a model to accelerate compulsory basic education completion toward Millennium Development Goals (MDGs) in Magelang, Indonesia. The study focuses on five issues: (1) profile of MDGs in Magelang, (2) achievement of MDGs, (3) problems in MDGs implementation, (4) model of compulsary basic…
Hacke, Peter; Spataru, Sergiu; Terwilliger, Kent;
2015-01-01
An acceleration model based on the Peck equation was applied to power performance of crystalline silicon cell modules as a function of time and of temperature and humidity, which are the two main environmental stress factors that promote potential-induced degradation (PID). This model was derived...
Hacke, Peter; Spataru, Sergiu; Terwilliger, Kent;
2015-01-01
An acceleration model based on the Peck equation was applied to power performance of crystalline silicon cell modules as a function of time and of temperature and humidity, the two main environmental stress factors that promote potential-induced degradation. This model was derived from module pow...
Late cosmic acceleration in a vector--Gauss-Bonnet gravity model
Oliveros, A; Acero, Mario A
2016-01-01
In this work we study a general vector-tensor model of dark energy with a Gauss-Bonnet term coupled to a vector field and without explicit potential terms. Considering a spatially flat FRW type universe and a vector field without spatial components, the cosmological evolution is analysed from the field equations of this model, considering two sets of parameters. In this context, we have shown that it is possible to obtain an accelerated expansion phase of the universe, since the equation state parameter $w$ satisfies the restriction $-1
The accelerating universe and other cosmological aspects of modified gravity models
de Felice, Antonio
I give a short introduction to standard cosmology and a review of what it is meant by "the dark energy enigma" in chapter l. In chapter 2, I mention and describe some attempts found in the literature of the past few years to attack this problem. Dark energy candidates for which the equation-of-state parameter w is less than -1 violate the dominant energy condition. In scalar-tensor theories of gravity, however, the expansion of the universe can mimic the behavior of general relativity with w the universe in such models, examining the possibilities for cosmic acceleration and other ultimate destinies. The models generically possess de Sitter space as an unstable solution and exhibit an interesting set of attractor solutions which, in some cases, provide alternatives to dark energy models. In chapter 5, I study a baryogenesis mechanism operating in the context of hyperextended inflation and making use of a coupling between the scalar field and a standard model global current, such as B or B - L . The method is efficient at temperatures at which these currents are not conserved due to some higher dimensional operator. The particle physics and cosmological phenomenology are discussed. I consider constraints stemming from nucleosynthesis and solar system experiments.
A Feasibility Study on Porting the Community Land Model onto Accelerators Using Openacc
D. Wang
2014-12-01
Full Text Available As environmental models (such as Accelerated Climate Model for Energy (ACME, Parallel Reactive Flow and Transport Model (PFLOTRAN, Arctic Terrestrial Simulator (ATS, etc. became more and more complicated, we are facing enormous challenges regarding to porting those applications onto hybrid computing architecture. OpenACC emerges as a very promising technology, therefore, we have conducted a feasibility analysis on porting the Community Land Model (CLM, a terrestrial ecosystem model within the Community Earth System Models (CESM. Specifically, we used automatic function testing platform to extract a small computing kernel out of CLM, then we apply this kernel into the actually CLM dataflow procedure, and investigate the strategy of data parallelization and the benefit of data movement provided by current implementation of OpenACC. Even it is a non-intensive kernel, on a single 16-core computing node, the performance (based on the actual computation time using one GPU of OpenACC implementation is 2.3 time faster than that of OpenMP implementation using single OpenMP thread, but it is 2.8 times slower than the performance of OpenMP implementation using 16 threads. On multiple nodes, MPI_OpenACC implementation demonstrated very good scalability on up to 128 GPUs on 128 computing nodes. This study also provides useful information for us to look into the potential benefits of “deep copy” capability and “routine” feature of OpenACC standards. We believe that our experience on the environmental model, CLM, can be beneficial to many other scientific research programs who are interested to porting their large scale scientific code using OpenACC onto high-end computers, empowered by hybrid computing architecture.
Afanasiev, Alexandr; Battarbee, Markus; Vainio, Rami; Rouillard, Alexis; Aran, Angels; Sipola, Robert; Pomoell, Jens
2016-04-01
The EU/H2020 project "High Energy Solar Particle Events foRecastIng and Analysis" (HESPERIA) has an objective to gain improved understanding of solar energetic particle (SEP) acceleration, release and transport related to long-duration gamma-ray emissions recently observed by Fermi/LAT. We have performed simulation studies for particle acceleration and transport for the 17 May 2012 event, which is also a Ground Level Enhancement (GLE) of solar cosmic rays. The particle event is modeled assuming that it is accelerated by the shock wave driven by the erupting coronal mass ejection (CME). We first analyze the 3-dimensional propagation of the shock through the corona using imaging observations from SDO, SOHO and STEREO spacecraft. The derived kinematics of the shock is combined with magnetohydrodynamic and potential field modeling of the ambient corona to derive the evolution of the shock parameters on a large set of field lines. We then employ the self-consistent Coronal Shock Acceleration (CSA) simulation model of the University of Turku to study the acceleration process on selected field lines and combine it with a new model of downstream particle transport to assess the energy spectrum and time profile of accelerated particles precipitating in the dense surface regions below the corona. We also employ the Shock and Particle (SaP) simulation model of the University of Barcelona to analyze the interplanetary counterpart of the Fermi event. In this paper, we will present the observations of the event, our approach to the modeling and the first results of the analysis. The work has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 637324 (HESPERIA).
History, development and characteristics of lake ecological models
无
2002-01-01
This paper provides some introductory information on the history, development, and characteristics of various lake ecosystem models.The modeling of lake ecological processes began to gain importance in the early 1960s. There are a number of models available today, with varying levels of complexity to cope with the variety of environmental problems found in lake environments, e.g. eutrophication, acidification,oxygen depletion, wetland management, heavy metal and pesticide pollution, as well as hydrodynamic problems. In particular, this paper focuses on lake eutrophication and wetland models, as well as addressing strategies appropriate for the design and development of reliable lake ecological models.
Stochastic modeling of uncertain mass characteristics in rigid body dynamics
Richter, Lanae A.; Mignolet, Marc P.
2017-03-01
This paper focuses on the formulation, assessment, and application of a modeling strategy of uncertainty on the mass characteristics of rigid bodies, i.e. mass, position of center of mass, and inertia tensor. These characteristics are regrouped into a 4×4 matrix the elements of which are represented as random variables with joint probability density function derived following the maximum entropy framework. This stochastic model is first shown to satisfy all properties expected of the mass and tensor of inertia of rigid bodies. Its usefulness and computational efficiency are next demonstrated on the behavior of a rigid body in pure rotation exhibiting significant uncertainty in mass distribution.
Modelling of the water retention characteristic of deformable soils
Wang Yu
2016-01-01
Full Text Available A recently proposed water retention model has been further developed for the application on unsaturated deformable soils. The physical mechanisms underpinning the water retention characteristic of soils was at first described in terms of traditional theories of capillarity and interfacial physical chemistry at pore level. Then upscaling to macroscopic level of material scale in terms of average volume theorem produces an analytical formula for the water retention characteristic. The methodology produces an explicit form of the water retention curve as a function of three state parameters: the suction, the degree-of-water-saturation and the void-ratio. At last, the model has been tested using experimental measurements.
Chen, Shuang; Lee, Young Ho; Crother, Timothy R.; Fishbein, Michael; Zhang, Wenxuan; Yilmaz, Atilla; Shimada, Kenichi; Schulte, Danica J; Lehman, Thomas J.A.; Shah, Prediman K.; Arditi, Moshe
2012-01-01
Objective To investigate if Lactobacillus casei cell wall extract (LCWE)-induced Kawasaki Disease (KD) accelerates atherosclerosis in hypercholesterolemic mice. Method and Resuslts Apoe−/− or Ldlr−/− mice were injected with LCWE (KD mice) or PBS, fed high fat diet for 8 weeks, and atherosclerotic lesions in aortic sinuses (AS), arch (AC) and whole aorta were assessed. KD mice had larger, more complex aortic lesions with abundant collagen, and both extracellular and intracellular lipid and foam cells, compared to lesions in control mice despite similar cholesterol levels. Both Apoe−/− KD and Ldlr−/− KD mice showed dramatic acceleration in atherosclerosis vs. controls, with increases in en face aortic atherosclerosis and plaque size in both the AS and AC plaques. Accelerated atherosclerosis was associated with increased circulating IL-12p40, IFN-γ, TNF-α, and increased macrophage, DC, and T cell recruitment in lesions. Furthermore, daily injections of the IL-1Ra, which inhibits LCWE induced KD vasculitis, prevented the acceleration of atherosclerosis. Conclusions Our results suggest an important pathophysiologic link between coronary arteritis/vasculitis in the KD mouse model and subsequent atherosclerotic acceleration, supporting the concept that a similar relation may also be present in KD patients. These results also suggest that KD in childhood may predispose to accelerated and early atherosclerosis as adults. PMID:22628430
Kamhawi, Hani; Huang, Wensheng; Haag, Thomas; Spektor, Rostislav
2014-01-01
The National Aeronautics and Space Administration (NASA) Science Mission Directorate In-Space Propulsion Technology office is sponsoring NASA Glenn Research Center to develop a 4 kW-class Hall thruster propulsion system for implementation in NASA science missions. A study was conducted to assess the impact of varying the facility background pressure on the High Voltage Hall Accelerator (HiVHAc) thruster performance and voltage-current characteristics. This present study evaluated the HiVHAc thruster performance in the lowest attainable background pressure condition at NASA GRC Vacuum Facility 5 to best simulate space-like conditions. Additional tests were performed at selected thruster operating conditions to investigate and elucidate the underlying physics that change during thruster operation at elevated facility background pressure. Tests were performed at background pressure conditions that are three and ten times higher than the lowest realized background pressure. Results indicated that the thruster discharge specific impulse and efficiency increased with elevated facility background pressure. The voltage-current profiles indicated a narrower stable operating region with increased background pressure. Experimental observations of the thruster operation indicated that increasing the facility background pressure shifted the ionization and acceleration zones upstream towards the thruster's anode. Future tests of the HiVHAc thruster are planned at background pressure conditions that are expected to be two to three times lower than what was achieved during this test campaign. These tests will not only assess the impact of reduced facility background pressure on thruster performance, voltage-current characteristics, and plume properties; but will also attempt to quantify the magnitude of the ionization and acceleration zones upstream shifting as a function of increased background pressure.
Two-fluid Atmosphere from Decelerating to Accelerating FRW Dark Energy Models
Pradhan, Anirudh
2012-01-01
The evolution of the dark energy parameter within the scope of a spatially homogeneous and isotropic Friedmann-Robertson-Walker (FRW) model filled with perfect fluid and dark energy components is studied by revisiting the recent results (Amirhashchi et al. in Int. J. Theor. Phys. 50: 3529, 2011). The two sources are claimed to interact minimally so that their energy momentum tensors are conserved separately. To prevail the deterministic solution we consider a time dependent deceleration parameter (DP) i.e. $q = -\\frac{a\\ddot{a}}{\\dot{a}^{2}} = b(a(t))$, which yields a scale factor $a = [\\sinh (\\alpha t)]^{\\frac{1}{n}}$, where $\\alpha$ and $n$ are arbitrary constants. This provides for a model which generates a transition of the universe from the early decelerating phase to the recent accelerating phase. It is observed that the transition red shift ($z_{t}$) for our derived model with $q_{0} = -0.73$ is $\\cong 0.32$. This is in good agreement with the cosmological observations in the literature. The physical a...
The L(1/2) regularization approach for survival analysis in the accelerated failure time model.
Chai, Hua; Liang, Yong; Liu, Xiao-Ying
2015-09-01
The analysis of high-dimensional and low-sample size microarray data for survival analysis of cancer patients is an important problem. It is a huge challenge to select the significantly relevant bio-marks from microarray gene expression datasets, in which the number of genes is far more than the size of samples. In this article, we develop a robust prediction approach for survival time of patient by a L(1/2) regularization estimator with the accelerated failure time (AFT) model. The L(1/2) regularization could be seen as a typical delegate of L(q)(0regularization methods and it has shown many attractive features. In order to optimize the problem of the relevant gene selection in high-dimensional biological data, we implemented the L(1/2) regularized AFT model by the coordinate descent algorithm with a renewed half thresholding operator. The results of the simulation experiment showed that we could obtain more accurate and sparse predictor for survival analysis by the L(1/2) regularized AFT model compared with other L1 type regularization methods. The proposed procedures are applied to five real DNA microarray datasets to efficiently predict the survival time of patient based on a set of clinical prognostic factors and gene signatures.
A late time accelerated FRW model with scalar and vector fields via Noether symmetry
Vakili, Babak, E-mail: b-vakili@iauc.ac.ir
2014-11-10
We study the evolution of a three-dimensional minisuperspace cosmological model by the Noether symmetry approach. The phase space variables turn out to correspond to the scale factor of a flat Friedmann–Robertson–Walker (FRW) model, a scalar field with potential function V(ϕ) with which the gravity part of the action is minimally coupled and a vector field of its kinetic energy is coupled with the scalar field by a coupling function f(ϕ). Then, the Noether symmetry of such a cosmological model is investigated by utilizing the behavior of the corresponding Lagrangian under the infinitesimal generator of the desired symmetry. We explicitly calculate the form of the coupling function between the scalar and the vector fields and also the scalar field potential function for which such symmetry exists. Finally, by means of the corresponding Noether current, we integrate the equations of motion and obtain exact solutions for the scale factor, scalar and vector fields. It is shown that the resulting cosmology is an accelerated expansion universe for which its expansion is due to the presence of the vector field in the early times, while the scalar field is responsible of its late time expansion.
A late time accelerated FRW model with scalar and vector fields via Noether symmetry
Babak Vakili
2014-11-01
Full Text Available We study the evolution of a three-dimensional minisuperspace cosmological model by the Noether symmetry approach. The phase space variables turn out to correspond to the scale factor of a flat Friedmann–Robertson–Walker (FRW model, a scalar field with potential function V(ϕ with which the gravity part of the action is minimally coupled and a vector field of its kinetic energy is coupled with the scalar field by a coupling function f(ϕ. Then, the Noether symmetry of such a cosmological model is investigated by utilizing the behavior of the corresponding Lagrangian under the infinitesimal generator of the desired symmetry. We explicitly calculate the form of the coupling function between the scalar and the vector fields and also the scalar field potential function for which such symmetry exists. Finally, by means of the corresponding Noether current, we integrate the equations of motion and obtain exact solutions for the scale factor, scalar and vector fields. It is shown that the resulting cosmology is an accelerated expansion universe for which its expansion is due to the presence of the vector field in the early times, while the scalar field is responsible of its late time expansion.
Jian Liang
2012-03-01
Full Text Available A new method based on accelerated solvent extraction (ASE combined with response surface methodology (RSM modeling and optimization has been developed for the extraction of four lignans in Fructus Schisandrae (the fruits of Schisandra chinensis Baill. The RSM method, based on a three level and three variable Box-Behnken design (BBD, was employed to obtain the optimal combination of extraction condition. In brief, the lignans schizandrin, schisandrol B, deoxyschizandrin and schisandrin B were optimally extracted with 87% ethanol as extraction solvent, extraction temperature of 160 °C, static extraction time of 10 min, extraction pressure of 1,500 psi, flush volume of 60% and one extraction cycle. The 3D response surface plot and the contour plot derived from the mathematical models were applied to determine the optimal conditions. Under the above conditions, the experimental value of four lignans was 14.72 mg/g, which is in close agreement with the value predicted by the model.
A late time accelerated FRW model with scalar and vector fields via Noether symmetry
Vakili, Babak
2014-11-01
We study the evolution of a three-dimensional minisuperspace cosmological model by the Noether symmetry approach. The phase space variables turn out to correspond to the scale factor of a flat Friedmann-Robertson-Walker (FRW) model, a scalar field with potential function V (ϕ) with which the gravity part of the action is minimally coupled and a vector field of its kinetic energy is coupled with the scalar field by a coupling function f (ϕ). Then, the Noether symmetry of such a cosmological model is investigated by utilizing the behavior of the corresponding Lagrangian under the infinitesimal generator of the desired symmetry. We explicitly calculate the form of the coupling function between the scalar and the vector fields and also the scalar field potential function for which such symmetry exists. Finally, by means of the corresponding Noether current, we integrate the equations of motion and obtain exact solutions for the scale factor, scalar and vector fields. It is shown that the resulting cosmology is an accelerated expansion universe for which its expansion is due to the presence of the vector field in the early times, while the scalar field is responsible of its late time expansion.
Multi-core CPU or GPU-accelerated Multiscale Modeling for Biomolecular Complexes.
Liao, Tao; Zhang, Yongjie; Kekenes-Huskey, Peter M; Cheng, Yuhui; Michailova, Anushka; McCulloch, Andrew D; Holst, Michael; McCammon, J Andrew
2013-07-01
Multi-scale modeling plays an important role in understanding the structure and biological functionalities of large biomolecular complexes. In this paper, we present an efficient computational framework to construct multi-scale models from atomic resolution data in the Protein Data Bank (PDB), which is accelerated by multi-core CPU and programmable Graphics Processing Units (GPU). A multi-level summation of Gaus-sian kernel functions is employed to generate implicit models for biomolecules. The coefficients in the summation are designed as functions of the structure indices, which specify the structures at a certain level and enable a local resolution control on the biomolecular surface. A method called neighboring search is adopted to locate the grid points close to the expected biomolecular surface, and reduce the number of grids to be analyzed. For a specific grid point, a KD-tree or bounding volume hierarchy is applied to search for the atoms contributing to its density computation, and faraway atoms are ignored due to the decay of Gaussian kernel functions. In addition to density map construction, three modes are also employed and compared during mesh generation and quality improvement to generate high quality tetrahedral meshes: CPU sequential, multi-core CPU parallel and GPU parallel. We have applied our algorithm to several large proteins and obtained good results.
Lois A Gelfand
2016-03-01
Full Text Available Objective: Survival time is an important type of outcome variable in treatment research. Currently, limited guidance is available regarding performing mediation analyses with survival outcomes, which generally do not have normally distributed errors, and contain unobserved (censored events. We present considerations for choosing an approach, using a comparison of semi-parametric proportional hazards (PH and fully parametric accelerated failure time (AFT approaches for illustration.Method: We compare PH and AFT models and procedures in their integration into mediation models and review their ability to produce coefficients that estimate causal effects. Using simulation studies modeling Weibull-distributed survival times, we compare statistical properties of mediation analyses incorporating PH and AFT approaches (employing SAS procedures PHREG and LIFEREG, respectively under varied data conditions, some including censoring. A simulated data set illustrates the findings.Results: AFT models integrate more easily than PH models into mediation models. Furthermore, mediation analyses incorporating LIFEREG produce coefficients that can estimate causal effects, and demonstrate superior statistical properties. Censoring introduces bias in the coefficient estimate representing the treatment effect on outcome – underestimation in LIFEREG, and overestimation in PHREG. With LIFEREG, this bias can be addressed using an alternative estimate obtained from combining other coefficients, whereas this is not possible with PHREG.Conclusions: When Weibull assumptions are not violated, there are compelling advantages to using LIFEREG over PHREG for mediation analyses involving survival-time outcomes. Irrespective of the procedures used, the interpretation of coefficients, effects of censoring on coefficient estimates, and statistical properties should be taken into account when reporting results.
SHI Pan; SUN Zhongmiao; XIAO Yun
2004-01-01
On the basis of a sinusoidal model of the disturbed horizontal acceleration, the spectrum characteristics of misaligned angle and horizontal acceleration correction are analyzed. In an airborne gravimetry test, the misaligned angle of platform and horizontal acceleration correction are calculated. They are 5'and 3 mGal, respectively, when the flight is stable.
Analysis of low energy arc discharge characteristics based on dynamic V-A characteristics model
JING Li-nan; WANG Li-gong
2006-01-01
Low energy arc discharge characteristics was analyzed based on dynamic V-A characteristics model. It draws conclusions that discharge time relates to the source voltage and the product of inductance and stable current, discharge time will increase when the source voltage increases; current reduce rate is in inverse proportion to the value of inductance; arc resistance when the arc occurs is the ratio of minimum arcing voltage to stable current. It also gains the expressions of arc resistance and arc power, arc resistance and arc power both increase as the source voltage increases and decrease as the value of inductance increases. Conclusions above mentioned are helpful to design intrinsically safe circuits.
Hong, Chang-Ki; Park, Chi Ho; Han, Joong-hee; Kwon, Jay Hyoun
2015-07-13
In order to obtain precise kinematic global positioning systems (GPS) in medium to large scale networks, the atmospheric effects from tropospheric and ionospheric delays need to be properly modeled and estimated. It is also preferable to use multiple reference stations to improve the reliability of the solutions. In this study, GPS kinematic positioning algorithms are developed for the medium to large-scale network based on the position-velocity-acceleration model. Hence, the algorithm can perform even in cases where the near-constant velocity assumption does not hold. In addition, the estimated kinematic accelerations can be used for the airborne gravimetry. The proposed algorithms are implemented using Kalman filter and are applied to the in situ airborne GPS data. The performance of the proposed algorithms is validated by analyzing and comparing the results with those from reference values. The results show that reliable and comparable solutions in both position and kinematic acceleration levels can be obtained using the proposed algorithms.
Study of Electron Acceleration and Multiple Dipolarization Fronts in 3D kinetic models
Lapenta, Giovanni; Ashour-Abdalla, Maha; Walker, Raymond; El-Alaoui, Mostafa
2014-05-01
The THEMIS mission encountered a depolarization front (DF) during a magnetotail crossing in the interval 035600 - 035900 UT on February 15, 2008 [1]. We present the results of an innovative investigative approach: we combine a global MHD model of the full Earth environment with a local PIC simulation. The global MHD view is provided on the UCLA model applied to the conditions for the interval of interest on Feb 15, 2008. At the specific time of 034800UT, a reconnection site first appear at about x=-15RE, y=4RE. We then use this specific MHD state as the initial setup for a fully kinetic PIC simulation, performed with the iPic3D code [2]. We consider a one way coupling where the MHD state is used as initial state and boundary conditions for the kinetic study [3]. In the present case, the time span of the kinetic simulation is short form the perspective of the global MHD simulation and does not require a full coupling where the MHD then process the information received back from the kinetic run [4]. The fields and particles are advanced self-consistently from the MHD state using a completely kinetic treatment. Many features missed by the MHD model emerge. Most notably a fast reconnection pattern develops and an unsteady reconnection process develops. The typical signatures of fast kinetic reconnection (Hall field) are observed and particle acceleration is obtained self consistently in the fields generated by the PIC simulation. The focus of the presentation will be the mechanisms of unsteady reconnection leading to multiple DFs. We observe intense wave activity propagating off the separatrices. We conduct a spectral analysis to isolate the different wave components in the lower hybrid and whistler regime. The unsteady reconnection and multiple DFs are also analysed in their impact on the energy transfer. We track the conversion of magnetic energy to particle energy and Poynting flux. The processes observed in the simulation are then compared with in situ THEMIS data
The influences of model parameters on the characteristics of memristors
Zhou Jing; Huang Da
2012-01-01
As the fourth passive circuit component,a memristor is a nonlinear resistor that can "remember" the amount of charge passing through it.The characteristic of "remembering" the charge and non-volatility makes memristors great potential candidates in many fields.Nowadays,only a few groups have the ability to fabricate memristors,and most researchers study them by theoretic analysis and simulation.In this paper,we first analyse the theoretical base and characteristics of memristors,then use a simulation program with integrated circuit emphasis as our tool to simulate the theoretical model of memristors and change the parameters in the model to see the influence of each parameter on the characteristics.Our work supplies researchers engaged in memristor-based circuits with advice on how to choose the proper parameters.
Vincent, John J.
The delineation of analysis techniques for high power radio frequency resonators, used as a fundamental component of particle accelerators, receives little attention in the literature. This dissertation reviews, describes, and develops techniques for resolving a transmission line mode rf resonator into an approximate equivalent circuit. Specifically, it presents a toolbox of techniques used to model and represent rf structures. One technique develops models of transmission lines with varying characteristic impedance (referred to as non-uniform) using multiple series connected circuits consisting of lumped elements and constant impedance transmission lines based on a conserved energy approach. This technique is tested for exponentially tapered and linearly tapered quarter-wave resonators. Another technique developed, maps transmission lines with arbitrary cross-sections (referred to as nonstandard) to a standard structure that preserves the characteristic impedance and loss properties of the original line. The techniques developed are applied to the analysis of the complex K1200 Superconducting Cyclotron rf resonators at the National Superconducting Cyclotron Laboratory (NSCL). The results predicted from the model are compared to measurements. The K1200 rf resonators are tunable over the frequency range of 9.5 to 27 MHz with tuning stems that vary from 300 cm to 11 cm respectively. The resonators are operated in the continuos wave (cw) mode and sustain peak voltages of up to 180 kV requiring drive power of up to 250 kW. Using the techniques developed, the resonant frequency versus tuning stem position was predicted to within a positioning error that varied from 1 to 3.5 cm over the tuning range of 9.5 to 27 Mhz. The discrepancy between model predictions and the experimental data for the resonator power dissipation is postulated to be due to high surface resistance in regions where the rf surfaces were heavily worked or welded. After adjusting the surface resistance
Linear Characteristic Graphical Models: Representation, Inference and Applications
Bickson, Danny
2010-01-01
Heavy-tailed distributions naturally occur in many real life problems. Unfortunately, it is typically not possible to compute inference in closed-form in graphical models which involve such heavy-tailed distributions. In this work, we propose a novel simple linear graphical model for independent latent random variables, called linear characteristic model (LCM), defined in the characteristic function domain. Using stable distributions, a heavy-tailed family of distributions which is a generalization of Cauchy, L\\'evy and Gaussian distributions, we show for the first time, how to compute both exact and approximate inference in such a linear multivariate graphical model. LCMs are not limited to stable distributions, in fact LCMs are always defined for any random variables (discrete, continuous or a mixture of both). We provide a realistic problem from the field of computer networks to demonstrate the applicability of our construction. Other potential application is iterative decoding of linear channels with non-...
M. Alvanos
2017-10-01
Full Text Available This paper presents an application of GPU accelerators in Earth system modeling. We focus on atmospheric chemical kinetics, one of the most computationally intensive tasks in climate–chemistry model simulations. We developed a software package that automatically generates CUDA kernels to numerically integrate atmospheric chemical kinetics in the global climate model ECHAM/MESSy Atmospheric Chemistry (EMAC, used to study climate change and air quality scenarios. A source-to-source compiler outputs a CUDA-compatible kernel by parsing the FORTRAN code generated by the Kinetic PreProcessor (KPP general analysis tool. All Rosenbrock methods that are available in the KPP numerical library are supported.Performance evaluation, using Fermi and Pascal CUDA-enabled GPU accelerators, shows achieved speed-ups of 4. 5 × and 20. 4 × , respectively, of the kernel execution time. A node-to-node real-world production performance comparison shows a 1. 75 × speed-up over the non-accelerated application using the KPP three-stage Rosenbrock solver. We provide a detailed description of the code optimizations used to improve the performance including memory optimizations, control code simplification, and reduction of idle time. The accuracy and correctness of the accelerated implementation are evaluated by comparing to the CPU-only code of the application. The median relative difference is found to be less than 0.000000001 % when comparing the output of the accelerated kernel the CPU-only code.The approach followed, including the computational workload division, and the developed GPU solver code can potentially be used as the basis for hardware acceleration of numerous geoscientific models that rely on KPP for atmospheric chemical kinetics applications.
A model for voltage collapse study considering load characteristics
Aguiar, L.B. [Companhia de Energia Eletrica da Bahia (COELBA), Salvador, BA (Brazil)
1994-12-31
This paper presents a model for analysis of voltage collapse and instability problem considering the load characteristics. The model considers fundamentally the transmission lines represented by exact from through the generalized constants A, B, C, D and the loads as function of the voltage, emphasizing the cases of constant power, constant current and constant impedance. the study treats of the system behavior on steady state and presents illustrative graphics about the problem. (author) 12 refs., 4 figs.
Distributed Leadership as Work Redesign: Retrofitting the Job Characteristics Model
Mayrowetz, David; Murphy, Joseph; Louis, Karen Seashore; Smylie, Mark A.
2007-01-01
In this article, we revive work redesign theory, specifically Hackman and Oldham's Job Characteristics Model (JCM), to examine distributed leadership initiatives. Based on our early observations of six schools engaged in distributed leadership reform and a broad review of literature, including empirical tests of work redesign theory, we retrofit…
The method of characteristics applied to analyse 2DH models
Sloff, C.J.
1992-01-01
To gain insight into the physical behaviour of 2D hydraulic models (mathematically formulated as a system of partial differential equations), the method of characteristics is used to analyse the propagation of physical meaningful disturbances. These disturbances propagate as wave fronts along bichar
Kelvin wave packets and flow acceleration - A comparison of modeling and observations
Coy, L.; Hitchman, M.
1984-01-01
Atmospheric Kelvin waves, as revealed by temperatures obtained from the recent Limb Infrared Monitor of the Stratosphere (LIMS) experiment, commonly occur in packets. A simple two-dimensional gravity-wave model is used to study the upward propagation of these packets through different zonal mean wind profiles derived from the LIMS data. The observed prevalence of high frequency waves in the lower mesosphere and low frequency waves in the lower stratosphere can be exlained by dispersion of energy associated with the range of frequencies comprising a packet. Dominant wave frequencies at upper and lower levels are more distinctly separated if the packet propagates through a layer of westerly winds. Due to dispersion and shear effects, a packet of short temporal length at low levels will have a considerably extended impact on a layer of westerly winds at higher levels. Observed and modeled westerly accelerations resulting from packet absorption occur in the same layer, and are similar in magnitude and duration. These results support the theory that Kelvin waves are responsible for the westerly phase of the semiannual oscillation.
Accelerating a Network Model of Care: Taking a Social Innovation to Scale
Kerry Byrne
2012-07-01
Full Text Available Government-funded systems of health and social care are facing enormous fiscal and human-resource challenges. The space for innovation in care is wide open and new disruptive patterns are emerging. These include self-management and personal budgets, participatory and integrated care, supported decision making and a renewed focus on prevention. Taking these disruptive patterns to scale can be accelerated by a technologically enabled shift to a network model of care to co-create the best outcomes for individuals, family caregivers, and health and social care organizations. The connections, relationships, and activities within an individual’s personal network lay the foundation for care that health and social care systems/policy must simultaneously support and draw on for positive outcomes. Practical tools, adequate information, and tangible resources are required to coordinate and sustain care. Tyze Personal Networks is a social venture that uses technology to engage and inform the individual, their personal networks, and their care providers to co-create the best outcomes. In this article, we demonstrate how Tyze contributes to a shift to a network model of care by strengthening our networks and enhancing partnerships between care providers, individuals, and family and friends.
Accelerating Neuronal Aging in In Vitro Model Brain Disorders: a Focus on Reactive Oxygen Species
Priscila Britto Campos
2014-10-01
Full Text Available In this review, we discuss insights gained through the use of stem cell preparations regarding the modeling of neurological diseases, the need for aging neurons derived from pluripotent stem cells to further advance the study of late-onset adult neurological diseases, and the extent to which mechanisms linked to the mismanagement of ROS. The context of these issues can be revealed using the three disease states of Parkinson’s (PD, Alzheimer’s (AD, and schizophrenia, as considerable insights have been gained into these conditions through the use of stem cells in terms of disease etiologies and the role of oxidative stress. The latter subject is a primary area of interest of our group. After discussing the molecular models of accelerated aging, we highlight the role of ROS for the three diseases explored here. Importantly, we do not seek to provide an extensive account of all genetic mutations for each of the three disorders discussed in this review, but we aim instead to provide a conceptual framework that could maximize the gains from merging the approaches of stem cell microsystems and the study of oxidative stress in disease in order to optimize therapeutics and determine new molecular targets against oxidative stress that spare stem cell proliferation and development.
Multi-GPU Accelerated Multi-Spin Monte Carlo Simulations of the 2D Ising Model
Block, Benjamin; Preis, Tobias; 10.1016/j.cpc.2010.05.005
2010-01-01
A modern graphics processing unit (GPU) is able to perform massively parallel scientific computations at low cost. We extend our implementation of the checkerboard algorithm for the two dimensional Ising model [T. Preis et al., J. Comp. Phys. 228, 4468 (2009)] in order to overcome the memory limitations of a single GPU which enables us to simulate significantly larger systems. Using multi-spin coding techniques, we are able to accelerate simulations on a single GPU by factors up to 35 compared to an optimized single Central Processor Unit (CPU) core implementation which employs multi-spin coding. By combining the Compute Unified Device Architecture (CUDA) with the Message Parsing Interface (MPI) on the CPU level, a single Ising lattice can be updated by a cluster of GPUs in parallel. For large systems, the computation time scales nearly linearly with the number of GPUs used. As proof of concept we reproduce the critical temperature of the 2D Ising model using finite size scaling techniques.
Limited impairments of associative learning in a mouse model of accelerated senescence.
Yang, Yi; Wu, Guang-yan; Li, Xuan; Huang, He; Hu, Bo; Yao, Juan; Wu, Bing; Sui, Jian-feng
2013-11-15
Research concerning impairment of associative learning during aging remains limited. The senescence-accelerated mice (SAM) prone/8 (P8) has been proposed as a useful model for the study of aging, and SAM resistant/1(SAMR1) is its control as a normal aging strain. Classical eyeblink conditioning has long been served as a model of associative learning. In order to explore the effects of aging on associative learning in SAM, the present study successively tested three paradigms of eyeblink conditioning in SAMP8 and SAMR1: classical single cue trace eyeblink conditioning (TEC), discriminative trace eyeblink conditioning and reversal learning of TEC. Behavioral performance indicated that SAMP8 could acquire limited single-cue trace eyeblink conditioning task and two-tone discrimination trace eyeblink conditioning with a relative lower acquisition rate compared to SAMR1. Both SAMP8 and SAMR1 failed to acquire reversal learning of discriminative TEC, and SAMP8' startle reflex to tone CS was lower than SAMR1. These results indicated that the impairments of aging on associative learning were incomplete in SAMP8.
Model-based Acceleration of Parameter mapping (MAP) for saturation prepared radially acquired data.
Tran-Gia, Johannes; Stäb, Daniel; Wech, Tobias; Hahn, Dietbert; Köstler, Herbert
2013-12-01
A reconstruction technique called Model-based Acceleration of Parameter mapping (MAP) is presented allowing for quantification of longitudinal relaxation time and proton density from radial single-shot measurements after saturation recovery magnetization preparation. Using a mono-exponential model in image space, an iterative fitting algorithm is used to reconstruct one well resolved and consistent image for each of the projections acquired during the saturation recovery relaxation process. The functionality of the algorithm is examined in numerical simulations, phantom experiments, and in-vivo studies. MAP reconstructions of single-shot acquisitions feature the same image quality and resolution as fully sampled reference images in phantom and in-vivo studies. The longitudinal relaxation times obtained from the MAP reconstructions are in very good agreement with the reference values in numerical simulations as well as phantom and in-vivo measurements. Compared to available contrast manipulation techniques, no averaging of projections acquired at different time points of the relaxation process is required in MAP imaging. The proposed technique offers new ways of extracting quantitative information from single-shot measurements acquired after magnetization preparation. The reconstruction simultaneously yields images with high spatiotemporal resolution fully consistent with the acquired data as well as maps of the effective longitudinal relaxation parameter and the relative proton density. Copyright © 2013 Wiley Periodicals, Inc., a Wiley company.
Lü Jian-Bo; Xu Li-Xin; Liu Mo-Lin; Gui Yuan-Xing
2009-01-01
In the framework of a five-dimensional(5D)bounce cosmological model,a useful function f(z)is obtained by giving a concrete expression of deceleration parameter q(z)=q1+q2/1+1n(1+z).Then usng the obtained Hubble parameter H(z)according to the function f(z),we constrain the accelerating universe from recent cosmic observations:the 192 ESSENCE SNe Ia and the 9 observational H(z)data.The best fitting values of transition redshift zT and current deceleration parameter q0 are given as zT=o.65±0.25-0.12 and q0=-0.76+0.15-0.15(1σ).Furthermore,in the 5D bounce model it can be seen that the evolution of equation of state(EOS)for dark energy ωde can cross over-1 at about z=0.23 and the current value ω0de=1.15＜-1.On the other hand,by giving a concrete expression of model-independent EOS of dark energy ωde,in the 5D bounce model we obtain the best fitting values zT=0.66+0311-0.08 and q0=-0.69+0.10-0.10(1σ)from the recently observed data:the 192 ESSENCE SNe Ia,the observational H(z)data,the 3-year Wilkinson Microwave Anisotropy Probe(WMAP),the Sloan Digital Sky Survey(SDSS)baryon acoustic peak and the x-ray gas mass fraction in clusters.
Kernel based methods for accelerated failure time model with ultra-high dimensional data
Jiang Feng
2010-12-01
Full Text Available Abstract Background Most genomic data have ultra-high dimensions with more than 10,000 genes (probes. Regularization methods with L1 and Lp penalty have been extensively studied in survival analysis with high-dimensional genomic data. However, when the sample size n ≪ m (the number of genes, directly identifying a small subset of genes from ultra-high (m > 10, 000 dimensional data is time-consuming and not computationally efficient. In current microarray analysis, what people really do is select a couple of thousands (or hundreds of genes using univariate analysis or statistical tests, and then apply the LASSO-type penalty to further reduce the number of disease associated genes. This two-step procedure may introduce bias and inaccuracy and lead us to miss biologically important genes. Results The accelerated failure time (AFT model is a linear regression model and a useful alternative to the Cox model for survival analysis. In this paper, we propose a nonlinear kernel based AFT model and an efficient variable selection method with adaptive kernel ridge regression. Our proposed variable selection method is based on the kernel matrix and dual problem with a much smaller n × n matrix. It is very efficient when the number of unknown variables (genes is much larger than the number of samples. Moreover, the primal variables are explicitly updated and the sparsity in the solution is exploited. Conclusions Our proposed methods can simultaneously identify survival associated prognostic factors and predict survival outcomes with ultra-high dimensional genomic data. We have demonstrated the performance of our methods with both simulation and real data. The proposed method performs superbly with limited computational studies.
Hearing characteristics of cephalopods: modeling and environmental impact study.
Zhang, Yunfeng; Shi, Feng; Song, Jiakun; Zhang, Xugang; Yu, Shiliang
2015-01-01
Cephalopods (octopus, squid and cuttlefish) are some of the most intriguing molluscs, and they represent economically important commercial marine species for fisheries. Previous studies have shown that cephalopods are sensitive to underwater particle motion, especially at low frequencies in the order of 10 Hz. The present paper deals with quantitative modeling of the statocyst system in three cephalopod species: Octopus vulgaris, Sepia officinalis and Loligo vulgaris. The octopus's macula/statolith organ was modeled as a 2nd-order dynamic oscillator using parameter values estimated from scanning electron micrograph images. The modeling results agree reasonably well with experimental data (acceleration threshold) in the three cephalopod species. Insights made from quantitative modeling and simulating the particle motion sensing mechanism of cephalopods elucidated their underwater particle motion detection capabilities. Sensitivity to emerging environmental issues, such as low frequency noise caused by near-shore wind farms and increasing levels of carbon dioxide in the ocean, and sensitivity to sounds produced by impending landslides were investigated in octopus using the model.
Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8
Patricia Castano-Prat
2017-05-01
Full Text Available The senescence-accelerated mouse prone 8 (SAMP8 model is characterized by accelerated, progressive cognitive decline as well as Alzheimer’s disease (AD-like neurodegenerative changes, and resembles the etiology of multicausal, sporadic late-onset/age-related AD in humans. Our aim was to find whether these AD-like pathological features, together with the cognitive deficits present in the SAMP8 strain, are accompanied by disturbances in cortical network activity with respect to control mice (SAM resistance 1, SAMR1 and, if so, how the alterations in cortical activity progress with age. For this purpose, we characterized the extracellular spontaneous oscillatory activity in different regions of the cerebral cortex of SAMP8 and SAMR1 mice under ketamine anesthesia at 5 and 7 months of age. Under these conditions, slow oscillations and fast rhythms generated in the cortical network were recorded and different parameters of these oscillations were quantified and compared between SAMP8 and their control, SAMR1 mice. The average frequency of slow oscillations in SAMP8 mice was decreased with respect to the control mice at both studied ages. An elongation of the silent periods or Down states was behind the decreased slow oscillatory frequency while the duration of active or Up states remained stable. SAMP8 mice also presented increased cycle variability and reduced high frequency components during Down states. During Up states, the power peak in the gamma range was displaced towards lower frequencies in all the cortical areas of SAMP8 with respect to control mice suggesting that the spectral profile of SAMP8 animals is shifted towards lower frequencies. This shift is reminiscent to one of the principal hallmarks of electroencephalography (EEG abnormalities in patients with Alzheimer’s disease, and adds evidence in support of the suitability of the SAMP8 mouse as a model of this disease. Although some of the differences between SAMP8 and control mice
Rajaraman, V.; Hau, B.S.; Rocha, L.A.; French, P.J.; Makinwa, K.A.A.
2010-01-01
This work reports on the design and modeling of a new flexible contact-mode 1-DOF piezoresistive contact force and impacttime detector used for acceleration sensing in the time domain. The key advantages of the contact-mode detection mechanism are the use of simple readout circuitry, compactness,
Rajaraman, V.; Hau, B.S.; Rocha, L.A.; French, P.J.; Makinwa, K.A.A.
2010-01-01
This work reports on the design and modeling of a new flexible contact-mode 1-DOF piezoresistive contact force and impacttime detector used for acceleration sensing in the time domain. The key advantages of the contact-mode detection mechanism are the use of simple readout circuitry, compactness, go
Kroon, John J.; Becker, Peter A.; Justin, Finke; Dermer, Charles D.
2017-01-01
The Crab nebula is a persistent source of gamma-rays up to about 100 MeV due to synchrotron radiation from electrons/positrons emitting in an ambient magnetic field thought to be of magnitude B~200 μG. The radiating electrons are limited by radiation-reaction forces which place an upper limit of about 100 MeV on the gamma-ray photons it can produce. This normally quiescent nebula has been observed by AGILE and Fermi to undergo bright transients lasting about a week and characterized by a significant increase in gamma-ray flux far above the classical radiation-reaction limit, with energies often reaching 3 GeV. The flares imply a population of PeV electrons accelerated on sub-day timescales. The very short acceleration timescales and the observed emission above the radiation-reaction limit place severe constraints on contemporary shock acceleration models such as diffusive shock acceleration which cannot account for the temporal and energetic properties of the gamma-ray flares. In this component of my dissertation research, I revisit the problem and find an analytic solution to the Fokker-Planck equation which incorporates a variety of acceleration and loss terms. I find that the model can reproduce the various Fermi-LAT flare spectra well and that electrostatic acceleration is the most significant contributor to the underlying mechanisms responsible for the most energetic astrophysical particle population ever observed. I find that the spectra of all the Fermi-LAT flares from the Crab nebula can be reproduced with this model using magnetic fields that are in agreement with multi-wavelength observations.
Power Converters for Accelerators
Visintini, R
2015-01-01
Particle accelerators use a great variety of power converters for energizing their sub-systems; while the total number of power converters usually depends on the size of the accelerator or combination of accelerators (including the experimental setup), the characteristics of power converters depend on their loads and on the particle physics requirements: this paper aims to provide an overview of the magnet power converters in use in several facilities worldwide.
Physiotherapy practice in the private sector: organizational characteristics and models.
Perreault, Kadija; Dionne, Clermont E; Rossignol, Michel; Poitras, Stéphane; Morin, Diane
2014-08-29
Even if a large proportion of physiotherapists work in the private sector worldwide, very little is known of the organizations within which they practice. Such knowledge is important to help understand contexts of practice and how they influence the quality of services and patient outcomes. The purpose of this study was to: 1) describe characteristics of organizations where physiotherapists practice in the private sector, and 2) explore the existence of a taxonomy of organizational models. This was a cross-sectional quantitative survey of 236 randomly-selected physiotherapists. Participants completed a purpose-designed questionnaire online or by telephone, covering organizational vision, resources, structures and practices. Organizational characteristics were analyzed descriptively, while organizational models were identified by multiple correspondence analyses. Most organizations were for-profit (93.2%), located in urban areas (91.5%), and within buildings containing multiple businesses/organizations (76.7%). The majority included multiple providers (89.8%) from diverse professions, mainly physiotherapy assistants (68.7%), massage therapists (67.3%) and osteopaths (50.2%). Four organizational models were identified: 1) solo practice, 2) middle-scale multiprovider, 3) large-scale multiprovider and 4) mixed. The results of this study provide a detailed description of the organizations where physiotherapists practice, and highlight the importance of human resources in differentiating organizational models. Further research examining the influences of these organizational characteristics and models on outcomes such as physiotherapists' professional practices and patient outcomes are needed.
Cooling nozzles characteristics for numerical models of continuous casting
R. Pyszko
2013-10-01
Full Text Available Modelling the temperature field of a continuously cast strand is an important tool for the process diagnostics. The main preconditions for numerical simulation of the temperature field of the solidifying strand are correct boundary conditions, especially the surface condition in the secondary zone of the caster. The paper deals with techniques of determining the surface condition under cooling nozzles as well as their approximation and implementation into the model algorithm. Techniques used for laboratory measurements of both cold and hot spraying characteristics of water or water-air cooling nozzles are described. The relationship between the cold and hot characteristics was found. Implementation of such a dependence into the model algorithm reduces the duration and cost of laboratory measurements.
AN ITEM RESPONSE MODEL WITH SINGLE PEAKED ITEM CHARACTERISTIC CURVES - THE PARELLA MODEL
HOIJTINK, H; MOLENAAR, [No Value
In this paper an item response model (the PARELLA model) designed specifically for the measurement of attitudes and preferences will be introduced. In contrast with the item response models currently used (e.g. the Rasch model and, the two and three parameter logistic model) the item characteristic
Accelerating numerical modeling of wave propagation through 2-D anisotropic materials using OpenCL.
Molero, Miguel; Iturrarán-Viveros, Ursula
2013-03-01
We present an implementation of the numerical modeling of elastic waves propagation, in 2D anisotropic materials, using the new parallel computing devices (PCDs). Our study is aimed both to model laboratory experiments and explore the capabilities of the emerging PCDs by discussing performance issues. In the experiments a sample plate of an anisotropic material placed inside a water tank is rotated and, for every angle of rotation it is subjected to an ultrasonic wave (produced by a large source transducer) that propagates in the water and through the material producing some reflection and transmission signals that are recording by a "point-like" receiver. This experiment is numerically modeled by running a finite difference code covering a set of angles θ∈[-50°, 50°], and recorded the signals for the transmission and reflection results. Transversely anisotropic and weakly orthorhombic materials are considered. We accelerated the computation using an open-source toolkit called PyOpenCL, which lets one to easily access the OpenCL parallel computation API's from the high-level programming environment of Python. A speedup factor over 19 using the GPU is obtained when compared with the execution of the same program in parallel using a CPU multi-core (in this case we use the 4-cores that has the CPU). The performance for different graphic cards and operating systems is included together with the full 2-D finite difference code with PyOpenCL. Copyright © 2012 Elsevier B.V. All rights reserved.
Wilma A Stolk
Full Text Available The Global Program to Eliminate Lymphatic Filariasis (LF has a target date of 2020. This program is progressing well in many countries. However, progress has been slow in some countries, and others have not yet started their mass drug administration (MDA programs. Acceleration is needed. We studied how increasing MDA frequency from once to twice per year would affect program duration and costs by using computer simulation modeling and cost projections. We used the LYMFASIM simulation model to estimate how many annual or semiannual MDA rounds would be required to eliminate LF for Indian and West African scenarios with varied pre-control endemicity and coverage levels. Results were used to estimate total program costs assuming a target population of 100,000 eligibles, a 3% discount rate, and not counting the costs of donated drugs. A sensitivity analysis was done to investigate the robustness of these results with varied assumptions for key parameters. Model predictions suggested that semiannual MDA will require the same number of MDA rounds to achieve LF elimination as annual MDA in most scenarios. Thus semiannual MDA programs should achieve this goal in half of the time required for annual programs. Due to efficiency gains, total program costs for semiannual MDA programs are projected to be lower than those for annual MDA programs in most scenarios. A sensitivity analysis showed that this conclusion is robust. Semiannual MDA is likely to shorten the time and lower the cost required for LF elimination in countries where it can be implemented. This strategy may improve prospects for global elimination of LF by the target year 2020.
Evaluating the AS-level Internet models: beyond topological characteristics
Fan Zheng-Ping
2012-01-01
A surge number of models has been proposed to model the Internet in the past decades.However,the issue on which models are better to model the Internet has still remained a problem.By analysing the evolving dynamics of the Internet,we suggest that at the autonomous system (AS) level,a suitable Internet model,should at least be heterogeneous and have a linearly growing mechanism.More importantly,we show that the roles of topological characteristics in evaluating and differentiating Internet models are apparently over-estimated from an engineering perspective.Also,we find that an assortative network is not necessarily more robust than a disassortative network and that a smaller average shortest path length does not necessarily mean a higher robustness,which is different from the previous observations. Our analytic results are helpful not only for the Internet,but also for other general complex networks.
Characteristics of a Logistics-Based Business Model
Sandberg, Erik; Kihlén, Tobias; Abrahamsson, Mats
2011-01-01
In companies where excellence in logistics is decisive for the outperformance of competitors and logistics has an outspoken role for the strategy of the firm, there is present what we refer to here as a “logistics-based business model.” Based on a multiple case study of three Nordic retail companies, the purpose of this article is to explore the characteristics of such a logistics-based business model. As such, this research helps to provide structure to logistics-based business models and id...
Recent advances in high-performance modeling of plasma-based acceleration using the full PIC method
Vay, J.-L.; Lehe, R.; Vincenti, H.; Godfrey, B. B.; Haber, I.; Lee, P.
2016-09-01
Numerical simulations have been critical in the recent rapid developments of plasma-based acceleration concepts. Among the various available numerical techniques, the particle-in-cell (PIC) approach is the method of choice for self-consistent simulations from first principles. The fundamentals of the PIC method were established decades ago, but improvements or variations are continuously being proposed. We report on several recent advances in PIC-related algorithms that are of interest for application to plasma-based accelerators, including (a) detailed analysis of the numerical Cherenkov instability and its remediation for the modeling of plasma accelerators in laboratory and Lorentz boosted frames, (b) analytic pseudo-spectral electromagnetic solvers in Cartesian and cylindrical (with azimuthal modes decomposition) geometries, and (c) novel analysis of Maxwell's solvers' stencil variation and truncation, in application to domain decomposition strategies and implementation of perfectly matched layers in high-order and pseudo-spectral solvers.
Recent advances in high-performance modeling of plasma-based acceleration using the full PIC method
Vay, J.-L., E-mail: jlvay@lbl.gov [LBNL, Berkeley, CA 94720 (United States); Lehe, R. [LBNL, Berkeley, CA 94720 (United States); Vincenti, H. [CEA, Saclay (France); Godfrey, B.B. [LBNL, Berkeley, CA 94720 (United States); U. Maryland, College Park, MD 20742 (United States); Haber, I. [U. Maryland, College Park, MD 20742 (United States); Lee, P. [LPGP, CNRS, Université Paris-Saclay, 91405 Orsay (France)
2016-09-01
Numerical simulations have been critical in the recent rapid developments of plasma-based acceleration concepts. Among the various available numerical techniques, the particle-in-cell (PIC) approach is the method of choice for self-consistent simulations from first principles. The fundamentals of the PIC method were established decades ago, but improvements or variations are continuously being proposed. We report on several recent advances in PIC-related algorithms that are of interest for application to plasma-based accelerators, including (a) detailed analysis of the numerical Cherenkov instability and its remediation for the modeling of plasma accelerators in laboratory and Lorentz boosted frames, (b) analytic pseudo-spectral electromagnetic solvers in Cartesian and cylindrical (with azimuthal modes decomposition) geometries, and (c) novel analysis of Maxwell's solvers' stencil variation and truncation, in application to domain decomposition strategies and implementation of perfectly matched layers in high-order and pseudo-spectral solvers.
Optimization and Modeling of the Accelerator for the FERMI @ Elettra FEL
Di Mitri, S; Emma, P; Huang, Z; Wang, D; Wu, J; Zholents, A; Craievich, P
2005-01-01
Design studies are in progress to use the existing FERMI@Elettra linear accelerator for a seeded harmonic cascade FEL facility [1]. This accelerator will be upgraded to 1.2 GeV and equipped with a low-emittance RF photocathode gun, laser heater, two bunch compressors, and beam delivery system. We present an optimization study for all the components following the gun, with the aim of achieving high peak current, low energy spread and low emittance electron beam necessary for the FEL. Various operational scenarios are discussed. Results of accelerator simulations including effects of space charge, coherent synchrotron radiation, and wakefields are reported.
Darabi, F
2009-01-01
We study a $(4+D)$-dimensional Kaluza-Klein cosmology with a Robertson-Walker type metric having two scale factors $a$ and $R$, corresponding to $D$-dimensional internal space and 4-dimensional universe, respectively. By introducing an exotic matter in the form of perfect fluid with an special equation of state, as the space-time part of the higher dimensional energy-momentum tensor, a four dimensional effective decaying cosmological term appears as $\\lambda \\sim R^{-m}$ with $0 \\leq m\\leq 2$, playing the role of an evolving dark energy in the universe. By taking $m=2$, which has some interesting implications in reconciling observations with inflationary models and is consistent with quantum tunneling, the resulting Einstein's field equations yield the exponential solutions for the scale factors $a$ and $R$. These exponential behaviors may account for the dynamical compactification of extra dimensions and the accelerating expansion of the 4-dimensional universe in terms of Hubble parameter, $H$. The accelerat...
Modeling of Blood Lead Levels in Astronauts Exposed to Lead from Microgravity-Accelerated Bone Loss
Garcia, H.; James, J.; Tsuji, J.
2014-01-01
Human exposure to lead has been associated with toxicity to multiple organ systems. Studies of various population groups with relatively low blood lead concentrations (adults. Cognitive effects are considered by regulatory agencies to be the most sensitive endpoint at low doses. Although 95% of the body burden of lead is stored in the bones, the adverse effects of lead correlate with the concentration of lead in the blood better than with that in the bones. NASA has found that prolonged exposure to microgravity during spaceflight results in a significant loss of bone minerals, the extent of which varies from individual to individual and from bone to bone, but generally averages about 0.5% per month. During such bone loss, lead that had been stored in bones would be released along with calcium. The effects on the concentration of lead in the blood (PbB) of various concentrations of lead in drinking water (PbW) and of lead released from bones due to accelerated osteoporosis in microgravity, as well as changes in exposure to environmental lead before, during, and after spaceflight were evaluated using a physiologically based pharmacokinetic (PBPK) model that incorporated exposure to environmental lead both on earth and in flight and included temporarily increased rates of osteoporosis during spaceflight.
Cifuentes, Diana; Poittevin, Marine; Dere, Ekrem; Broquères-You, Dong; Bonnin, Philippe; Benessiano, Joëlle; Pocard, Marc; Mariani, Jean; Kubis, Nathalie; Merkulova-Rainon, Tatyana; Lévy, Bernard I
2015-01-01
Cerebrovascular impairment is frequent in patients with Alzheimer disease and is believed to influence clinical manifestation and severity of the disease. Cardiovascular risk factors, especially hypertension, have been associated with higher risk of developing Alzheimer disease. To investigate the mechanisms underlying the hypertension, Alzheimer disease cross talk, we established a mouse model of dual pathology by infusing hypertensive doses of angiotensin II into transgenic APPPS1 mice overexpressing mutated human amyloid precursor and presenilin 1 proteins. At 4.5 months, at the early stage of disease progression, only hypertensive APPPS1 mice presented impairment of temporal order memory performance in the episodic-like memory task. This cognitive deficit was associated with an increased number of cortical amyloid deposits (223±5 versus 207±5 plaques/mm(2); PHypertensive APPPS1 mice presented several cerebrovascular alterations, including a 25% reduction in cerebral microvessel density and a 30% to 40% increase in cerebral vascular amyloid deposits, as well as a decrease in vascular endothelial growth factor A expression in the brain, compared with normotensive APPPS1 mice. Moreover, the brain levels of nitric oxide synthase 1 and 3 and the nitrite/nitrate levels were reduced in hypertensive APPPS1 mice (by 49%, 34%, and 33%, respectively, compared with wild-type mice; Phypertension accelerates the development of Alzheimer disease-related structural and functional alterations, partially through cerebral vasculature impairment and reduced nitric oxide production.
Immune responses accelerate ageing: proof-of-principle in an insect model.
E Rhiannon Pursall
Full Text Available The pathology of many of the world's most important infectious diseases is caused by the immune response. Additionally age-related disease is often attributed to inflammatory responses. Consequently a reduction in infections and hence inflammation early in life has been hypothesized to explain the rise in lifespan in industrialized societies. Here we demonstrate experimentally for the first time that eliciting an immune response early in life accelerates ageing. We use the beetle Tenebrio molitor as an inflammation model. We provide a proof of principle for the effects of early infection on morbidity late in life and demonstrate a long-lasting cost of immunopathology. Along with presenting a proof-of-principle study, we discuss a mechanism for the apparently counter-adaptive persistence of immunopathology in natural populations. If immunopathology from early immune response only becomes costly later in life, natural selection on reducing self-harm would be relaxed, which could explain the presence of immune self-harm in nature.
Shiga, Yasuhiro; Orita, Sumihisa; Kubota, Go; Kamoda, Hiroto; Yamashita, Masaomi; Matsuura, Yusuke; Yamauchi, Kazuyo; Eguchi, Yawara; Suzuki, Miyako; Inage, Kazuhide; Sainoh, Takeshi; Sato, Jun; Fujimoto, Kazuki; Abe, Koki; Kanamoto, Hirohito; Inoue, Masahiro; Kinoshita, Hideyuki; Aoki, Yasuchika; Toyone, Tomoaki; Furuya, Takeo; Koda, Masao; Takahashi, Kazuhisa; Ohtori, Seiji
2016-11-01
Fresh platelet-rich plasma (PRP) accelerates bone union in rat model. However, fresh PRP has a short half-life. We suggested freeze-dried PRP (FD-PRP) prepared in advance and investigated its efficacy in vivo. Spinal posterolateral fusion was performed on 8-week-old male Sprague-Dawley rats divided into six groups based on the graft materials (n = 10 per group): sham control, artificial bone (A hydroxyapatite–collagen composite) –alone, autologous bone, artificial bone + fresh-PRP, artificial bone + FD-PRP preserved 8 weeks, and artificial bone + human recombinant bone morphogenetic protein 2 (BMP) as a positive control. At 4 and 8 weeks after the surgery, we investigated their bone union–related characteristics including amount of bone formation, histological characteristics of trabecular bone at remodeling site, and biomechanical strength on 3-point bending. Comparable radiological bone union was confirmed at 4 weeks after surgery in 80% of the FD-PRP groups, which was earlier than in other groups (p < 0.05). Histologically, the trabecular bone had thinner and more branches in the FD-PRP. Moreover, the biomechanical strength was comparable to that of autologous bone. FD-PRP accelerated bone union at a rate comparable to that of fresh PRP and BMP by remodeling the bone with thinner, more tangled, and rigid trabecular bone.
Electromagnetic Model Reliably Predicts Radar Scattering Characteristics of Airborne Organisms
Mirkovic, Djordje; Stepanian, Phillip M.; Kelly, Jeffrey F.; Chilson, Phillip B.
2016-10-01
The radar scattering characteristics of aerial animals are typically obtained from controlled laboratory measurements of a freshly harvested specimen. These measurements are tedious to perform, difficult to replicate, and typically yield only a small subset of the full azimuthal, elevational, and polarimetric radio scattering data. As an alternative, biological applications of radar often assume that the radar cross sections of flying animals are isotropic, since sophisticated computer models are required to estimate the 3D scattering properties of objects having complex shapes. Using the method of moments implemented in the WIPL-D software package, we show for the first time that such electromagnetic modeling techniques (typically applied to man-made objects) can accurately predict organismal radio scattering characteristics from an anatomical model: here the Brazilian free-tailed bat (Tadarida brasiliensis). The simulated scattering properties of the bat agree with controlled measurements and radar observations made during a field study of bats in flight. This numerical technique can produce the full angular set of quantitative polarimetric scattering characteristics, while eliminating many practical difficulties associated with physical measurements. Such a modeling framework can be applied for bird, bat, and insect species, and will help drive a shift in radar biology from a largely qualitative and phenomenological science toward quantitative estimation of animal densities and taxonomic identification.
Characteristics of the Receptor for the Biosphere Model
M. Wasiolek; K. Rautenstrauch
2004-09-09
This analysis report is one of a series of technical reports that document the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the geologic repository at Yucca Mountain. This report is one of the five biosphere reports that develop input parameter values for the biosphere model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes the conceptual model, as well as the mathematical model and its input parameters. Figure 1-1 is a graphical representation of the documentation hierarchy for the ERMYN. This figure shows relationships among the products (i.e., scientific analyses and model reports) developed for biosphere modeling and biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan: for Biosphere Modeling and Expert Support'' (BSC 2004 [DIRS 169573]). The purpose of this analysis report is to define values for biosphere model parameters that are related to the dietary, lifestyle, and dosimetric characteristics of the receptor. The biosphere model, consistent with the licensing rule at 10 CFR Part 63 [DIRS 156605], uses a hypothetical person called the reasonably maximally exposed individual (RMEI) to represent the potentially exposed population. The parameters that define the RMEI are based on the behaviors and characteristics of the residents of the unincorporated town of Amargosa Valley, consistent with the requirements of 10 CFR 63.312 [DIRS 156605]. The output of this report is used as direct input in the two analyses identified in Figure 1-1 that calculate the values of biosphere dose conversion factors (BDCFs) for the groundwater and volcanic ash exposure scenarios. The parameter values developed in this report are reflected in the TSPA through the BDCFs. The analysis was performed in accordance with AP-SIII.9Q, ''Scientific Analyses'', and the technical work
Collaborative Visualization for Large-Scale Accelerator Electromagnetic Modeling (Final Report)
William J. Schroeder
2011-11-13
This report contains the comprehensive summary of the work performed on the SBIR Phase II, Collaborative Visualization for Large-Scale Accelerator Electromagnetic Modeling at Kitware Inc. in collaboration with Stanford Linear Accelerator Center (SLAC). The goal of the work was to develop collaborative visualization tools for large-scale data as illustrated in the figure below. The solutions we proposed address the typical problems faced by geographicallyand organizationally-separated research and engineering teams, who produce large data (either through simulation or experimental measurement) and wish to work together to analyze and understand their data. Because the data is large, we expect that it cannot be easily transported to each team member's work site, and that the visualization server must reside near the data. Further, we also expect that each work site has heterogeneous resources: some with large computing clients, tiled (or large) displays and high bandwidth; others sites as simple as a team member on a laptop computer. Our solution is based on the open-source, widely used ParaView large-data visualization application. We extended this tool to support multiple collaborative clients who may locally visualize data, and then periodically rejoin and synchronize with the group to discuss their findings. Options for managing session control, adding annotation, and defining the visualization pipeline, among others, were incorporated. We also developed and deployed a Web visualization framework based on ParaView that enables the Web browser to act as a participating client in a collaborative session. The ParaView Web Visualization framework leverages various Web technologies including WebGL, JavaScript, Java and Flash to enable interactive 3D visualization over the web using ParaView as the visualization server. We steered the development of this technology by teaming with the SLAC National Accelerator Laboratory. SLAC has a computationally
Accelerated cognitive decline in a rodent model for temporal lobe epilepsy
Schipper, Sandra; Aalbers, Marlien W.; Rijkers, Kim; Lagiere, Melanie; Bogaarts, Jan G.; Blokland, Arjan; Klinkenberg, Sylvia; Hoogland, Govert; Vles, Johan S. H.
2016-01-01
Objective: Cognitive impairment is frequently observed in patients with temporal lobe epilepsy. It is hypothesized that cumulative seizure exposure causes accelerated cognitive decline in patients with epilepsy. We investigated the influence of seizure frequency on cognitive decline in a rodent
Buford, Thomas W; Anton, Stephen D; Judge, Andrew R; Marzetti, Emanuele; Wohlgemuth, Stephanie E; Carter, Christy S; Leeuwenburgh, Christiaan; Pahor, Marco; Manini, Todd M
2010-10-01
Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population ages. Certain conditions have the strong potential to coincide with sarcopenia to accelerate the progression of muscle atrophy in older adults. Among these conditions are co-morbid diseases common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease. Furthermore, behaviors such as poor nutrition and physical inactivity are well-known to contribute to sarcopenia development. However, we argue that these behaviors are not inherent to the development of sarcopenia but rather accelerate its progression. In the present review, we discuss how these factors affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy. In addition, we describe gaps in the literature concerning the role of these factors in accelerating sarcopenia progression. Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia.
Torque model of hydro turbine with inner energy loss characteristics
无
2010-01-01
This paper presents the result and analysis of the composition of energy loss occurring in the hydro turbine. Two new types of energy losses,namely the hydraulic loss in the flow channel and the impact loss,are defined. All losses within the hydro turbine are divided into four types and the loss coefficients are defined accordingly. Expressions or characteristic descriptions of these losses as well as the calibration method of the loss coefficients are presented. Furthermore,the torque model of the hydro turbine where the inner energy loss takes place is established. The developed model has been used to calculate the power loss due to the mechanical friction generated by the units’ rotation to solve the difficulty of measurements of the mechanical friction loss in the hydro turbine. The definition of the impact loss explains the phenomenon that the loss of no-load is greater than that of the rated operation. A set of conversion coefficients are defined using the characteristic parameters at the rated operation,which are used to transform the parameters in the torque model into those that are easily measured. Therefore,the expression of the hydro turbine power is converted into a function that has the main servomotor displacement as its single variable. This makes the proposed model be convenient to use. Finally,the proposed model and methods are calibrated and verified using the measured data of a hydropower plant. Good agreement between the modeled results and the measurements indicates that the proposed model can represent the inner energy loss characteristics of the hydro turbine.
Varady, M.; Karlický, M.; Moravec, Z.; Kašparová, J.
2014-03-01
Context. The collisional thick-target model (CTTM) of the impulsive phase of solar flares, together with the famous Carmichael, Sturrock, Hirayama, and Kopp-Pneuman (CSHKP) model, presented for many years a "standard" model, which straightforwardly explained many observational aspects of flares. On the other hand, many critical issues appear when the concept is scrutinised theoretically or with the new generation of hard X-ray (HXR) observations. The famous "electron number problem" or problems related to transport of enormous particle fluxes though the corona represent only two of them. To resolve the discrepancies, several modifications of the CTTM appeared. Aims: We study two of them based on the global and local re-acceleration of non-thermal electrons by static and stochastic electric fields during their transport from the coronal acceleration site to the thick-target region in the chromosphere. We concentrate on a comparison of the non-thermal electron distribution functions, chromospheric energy deposits, and HXR spectra obtained for both considered modifications with the CTTM itself. Methods: The results were obtained using a relativistic test-particle approach. We simulated the transport of non-thermal electrons with a power-law spectrum including the influence of scattering, energy losses, magnetic mirroring, and also the effects of the electric fields corresponding to both modifications of the CTTM. Results: We show that both modifications of the CTTM change the outcome of the chromospheric bombardment in several aspects. The modifications lead to an increase in chromospheric energy deposit, change of its spatial distribution, and a substantial increase in the corresponding HXR spectrum intensity. Conclusions: The re-acceleration in both models reduces the demands on the efficiency of the primary coronal accelerator, on the electron fluxes transported from the corona downwards, and on the total number of accelerated coronal electrons during flares.
Modeling relaxor characteristics in systems of interacting dipoles
Kliem, Herbert; Leschhorn, Andreas, E-mail: a.leschhorn@mx.uni-saarland.de
2016-12-15
We present a model which derives typical relaxor characteristics from simple and plausible microscopic assumptions. The model is based on charges which fluctuate thermally activated in double well potentials. The double well potentials are asymmetric due to disorder in the system. The electrostatic interaction between the charges is considered via a mean field approach. This model yields the typical relaxor features: we find high susceptibilities in a broad temperature range with dynamics following the Vogel–Fulcher law. In the framework of the model no spontaneous polarization arises at cooling without strong external field in accordance to experimental findings for relaxors. Furthermore the model yields hysteresis loops which depend on the amplitude of the external field and which become more and more thin and deformed above the maximum temperature of the susceptibility.
A microcosmic discrete occupant evacuation model based on individual characteristics
YANG Lizhong; LI Jian; ZHAO Daoliang; FANG Weifeng; FAN Weicheng
2004-01-01
The research of occupant evacuation in an emergency is of great benefit to building design and evacuation guidance. In this paper a microcosmic discrete evacuation model based on Cellular Automata (CA) is presented, in which the occupants' individual characteristics are considered. Thus, our model has given a description of evacuation route choice with influencing factors, including: individual knowledge of the building,individual realization of the emergency development, and the attractive and repulsive force between occupants. This model differs somewhat from other models in the attention to the associative and separate effect of influencing factors, based on occupant's behaviors. In addition, the model could reveal the phenomenon of escape in fire, as those simulations involving a fire condition have shown.
Mathematical Modeling of Flow Characteristics in the Embryonic Chick Heart
Heebøll-Christensen, Jesper
. Furthermore it is concluded that the observed Liebau effect does depend on the impedance of the tubes, the frequency and position of the compression pump, but above all the characterization of the pumping function. Different pumping functions are employed in the modeling but no defining characteristics...... modified inertia, and resistance due to friction and curvature of the multilayered tubular heart. Through the modeling, flow conditions in the embryonic heart are characterized. The models suggest that eccentric rather than concentric deformation of the beating heart is optimal for mean flows induced...... the models are not conclusive on this point. In addition the Liebau effect is investigated in a simpler system containing two elastic tubes joined to form a liquid filled ring, with a compression pump at an asymmetric location. Through comparison to other reports the system validates model construction...
Particle MCMC algorithms and architectures for accelerating inference in state-space models.
Mingas, Grigorios; Bottolo, Leonardo; Bouganis, Christos-Savvas
2017-04-01
Particle Markov Chain Monte Carlo (pMCMC) is a stochastic algorithm designed to generate samples from a probability distribution, when the density of the distribution does not admit a closed form expression. pMCMC is most commonly used to sample from the Bayesian posterior distribution in State-Space Models (SSMs), a class of probabilistic models used in numerous scientific applications. Nevertheless, this task is prohibitive when dealing with complex SSMs with massive data, due to the high computational cost of pMCMC and its poor performance when the posterior exhibits multi-modality. This paper aims to address both issues by: 1) Proposing a novel pMCMC algorithm (denoted ppMCMC), which uses multiple Markov chains (instead of the one used by pMCMC) to improve sampling efficiency for multi-modal posteriors, 2) Introducing custom, parallel hardware architectures, which are tailored for pMCMC and ppMCMC. The architectures are implemented on Field Programmable Gate Arrays (FPGAs), a type of hardware accelerator with massive parallelization capabilities. The new algorithm and the two FPGA architectures are evaluated using a large-scale case study from genetics. Results indicate that ppMCMC achieves 1.96x higher sampling efficiency than pMCMC when using sequential CPU implementations. The FPGA architecture of pMCMC is 12.1x and 10.1x faster than state-of-the-art, parallel CPU and GPU implementations of pMCMC and up to 53x more energy efficient; the FPGA architecture of ppMCMC increases these speedups to 34.9x and 41.8x respectively and is 173x more power efficient, bringing previously intractable SSM-based data analyses within reach.
Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model.
Agmon-Levin, Nancy; Arango, María-Teresa; Kivity, Shaye; Katzav, Aviva; Gilburd, Boris; Blank, Miri; Tomer, Nir; Volkov, Alex; Barshack, Iris; Chapman, Joab; Shoenfeld, Yehuda
2014-11-01
Hepatitis-B vaccine (HBVv) can prevent HBV-infection and associated liver diseases. However, concerns regarding its safety, particularly among patients with autoimmune diseases (i.e. SLE) were raised. Moreover, the aluminum adjuvant in HBVv was related to immune mediated adverse events. Therefore, we examined the effects of immunization with HBVv or alum on SLE-like disease in a murine model. NZBWF1 mice were immunized with HBVv (Engerix), or aluminum hydroxide (alum) or phosphate buffered saline (PBS) at 8 and 12 weeks of age. Mice were followed for weight, autoantibodies titers, blood counts, proteinuria, kidney histology, neurocognitive functions (novel object recognition, staircase, Y-maze and the forced swimming tests) and brain histology. Immunization with HBVv induced acceleration of kidney disease manifested by high anti-dsDNA antibodies (p < 0.01), early onset of proteinuria (p < 0.05), histological damage and deposition of HBs antigen in the kidney. Mice immunized with HBVv and/or alum had decreased cells counts mainly of the red cell lineage (p < 0.001), memory deficits (p < 0.01), and increased activated microglia in different areas of the brain compare with mice immunized with PBS. Anxiety-like behavior was more pronounced among mice immunized with alum. In conclusion, herein we report that immunization with the HBVv aggravated kidney disease in an animal model of SLE. Immunization with either HBVv or alum affected blood counts, neurocognitive functions and brain gliosis. Our data support the concept that different component of vaccines may be linked with immune and autoimmune mediated adverse events.
An object-oriented, coprocessor-accelerated model for ice sheet simulations
Seddik, H.; Greve, R.
2013-12-01
Recently, numerous models capable of modeling the thermo-dynamics of ice sheets have been developed within the ice sheet modeling community. Their capabilities have been characterized by a wide range of features with different numerical methods (finite difference or finite element), different implementations of the ice flow mechanics (shallow-ice, higher-order, full Stokes) and different treatments for the basal and coastal areas (basal hydrology, basal sliding, ice shelves). Shallow-ice models (SICOPOLIS, IcIES, PISM, etc) have been widely used for modeling whole ice sheets (Greenland and Antarctica) due to the relatively low computational cost of the shallow-ice approximation but higher order (ISSM, AIF) and full Stokes (Elmer/Ice) models have been recently used to model the Greenland ice sheet. The advance in processor speed and the decrease in cost for accessing large amount of memory and storage have undoubtedly been the driving force in the commoditization of models with higher capabilities, and the popularity of Elmer/Ice (http://elmerice.elmerfem.com) with an active user base is a notable representation of this trend. Elmer/Ice is a full Stokes model built on top of the multi-physics package Elmer (http://www.csc.fi/english/pages/elmer) which provides the full machinery for the complex finite element procedure and is fully parallel (mesh partitioning with OpenMPI communication). Elmer is mainly written in Fortran 90 and targets essentially traditional processors as the code base was not initially written to run on modern coprocessors (yet adding support for the recently introduced x86 based coprocessors is possible). Furthermore, a truly modular and object-oriented implementation is required for quick adaptation to fast evolving capabilities in hardware (Fortran 2003 provides an object-oriented programming model while not being clean and requiring a tricky refactoring of Elmer code). In this work, the object-oriented, coprocessor-accelerated finite element
Modelling the reflective thermal contribution to the acceleration of the Pioneer spacecraft
Francisco, F., E-mail: frederico.francisco@ist.utl.pt [Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Bertolami, O., E-mail: orfeu.bertolami@fc.up.pt [Departamento de Fisica e Astronomia, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto (Portugal); Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Gil, P.J.S., E-mail: p.gil@dem.ist.utl.pt [Departamento de Engenharia Mecanica and IDMEC - Instituto de Engenharia Mecanica, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Paramos, J., E-mail: paramos@ist.edu [Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal)
2012-05-23
We present an improved method to compute the radiative momentum transfer in the Pioneer 10 and 11 spacecraft that takes into account both diffusive and specular reflection. The method allows for more reliable results regarding the thermal acceleration of the deep-space probes, confirming previous findings. A parametric analysis is performed in order to set upper and lower bounds for the thermal acceleration and its evolution with time.
Compact model for switching characteristics of graphene field effect transistor
Sreenath, R.; Bala Tripura Sundari, B.
2016-04-01
The scaling of CMOS transistors has resulted in intensified short channel effects, indicating that CMOS has reached its physical limits. Alternate non silicon based materials namely carbon based graphene, carbon nanotubes are being explored for usability as channel and interconnect material due to their established higher mobility and robustness. This paper presents a drift-diffusion based circuit simulatable Verilog-A compact model of graphene field effect transistor (GFET) for channel length of 100nm.The focus is on the development of simulatable device model in Verilog A based on intrinsic parameters and obtain the current, high cutoff frequency and use the model into circuit level simulations to realize an inverter and a 3-stage ring oscillator using Synopsys HSPICE. The applications are so chosen that their switching characteristics enable the determination of the RF frequency ranges of operation that the model can achieve when used in digital applications and also to compare its performance with existing CMOS model. The GFET's switching characteristics and power consumption were found to be better than similarly sized CMOS operating at same range of voltages. The basic frequency of operation in the circuit is of significant importance so as to use the model in other applications at RF and in future for millimeter wave applications. The frequency of operation at circuit level is found to be 1.1GHz at 100nm which is far higher than the existing frequency of 245 MHz reported at 500nm using AlN.
Unified power flow controller: modeling and dynamic characteristic
Bach, D. H.; Loc, H. D.
2005-12-01
Unified power flow controller (UPFC) consists two converters. There are three purposes of this paper, firstly to illustrate the UPFC device based VSC designs, then to describe a decoupling method the UPFC's controller into two separate control systems of the shunt and the series converters respectively in realizing an appropriate coordination between them. Finally, using the Matlab tool to build a discrete simulator for the UPFC with 12 pulse converters. The simulation results show that the developed UPFC model is reflected the static and dynamic characteristics of the UPFC. The harmonics of the output of the model were analyzed. Using the simple power system with UPFC as an example, the dynamics characteristics were studied. The fault status of the system with UPFC was analyzed too.
Ditmar, P.G.; Kuznetsov, V.; Van Eck van der Sluis, A.A.; Schrama, E.; Klees, R.
2005-01-01
Performance of a recently proposed technique for gravity field modeling has been assessed with data from the CHAMP satellite. The modeling technique is a variant of the acceleration approach. It makes use of the satellite accelerations that are derived from the kinematic orbit with the 3-point
Characteristics of the Receptor for the Biosphere Model
M.A. Wasiolek; K.R. Rautenstrauch
2003-06-27
This analysis report is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain Nevada (ERMYN), a biosphere model supporting the Total System Performance Assessment (TSPA) for the geologic repository at Yucca Mountain. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1-1. This figure shows relationships among the products (i.e., analysis and model reports) developed for biosphere modeling and biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan: for Biosphere Modeling and Expert Support'' (TWP) (BSC 2003). Some documents identified in Figure 1-1 may be under development and not available at the time this report is issued. This figure is included to provide an understanding of how this analysis report contributes to biosphere modeling in support of the license application, and access to the listed documents is not required to understand the contents of this report. This report is one of the reports that develop input parameter values for the biosphere model. The ''Biosphere Model Report'' (BSC 2003), describes the conceptual model as well as the mathematical model and its input parameters. The purpose of this analysis report is to define values for biosphere model parameters that are related to the dietary, lifestyle, and dosimetric characteristics of the receptor. The biosphere model, consistent with the licensing rule at 10 CFR Part 63, uses a hypothetical person called the reasonably maximally exposed individual (RMEI) to represent the potentially exposed population. The parameters that define the RMEI are based on the behaviors and characteristics of the Amargosa Valley population, consistent with the requirements of 10 CFR 63.312. Amargosa Valley is the community, located in the direction of the projected groundwater flow path, where most of the farming in the area occurs. The parameter values
Modeling and Visualizing the Particle Beam in the Rare Isotope Accelerator
Rosenthal, Christopher [Argonne National Lab., IL (United States); Erdelyi, Bela [Argonne National Lab., IL (United States); Northern Illinois Univ. (United States)
2006-01-01
Argonne National Laboratory is actively pursuing research and design for a Rare Isotope Accelerator (RIA) facility that will aid basic research in nuclear physics by creating beams of unstable isotopes. Such a facility has been labeled as a high priority by the joint Department of Energy and National Science Foundation Nuclear Science Advisory Committee because it will allow more study on the nature of nucleonic matter, the origin of the elements, the Standard Model, and nuclear medicine. An important part of this research is computer simulations that model the behavior of the particle beam, specifically in the Fragment Separator. The Fragment Separator selects isotopes based on their trajectory in electromagnetic fields and then uses absorbers to separate particles with a certain mass and charge from the rest of the beam. This project focused on the development of a multivariate, correlated Gaussian distribution to model the distribution of particles in the beam as well as visualizations and analysis to view how this distribution changed when passing through an absorber. The distribution was developed in the COSY INFINITY programming language. The user inputs a covariance matrix and a vector of means for the six phase space variables, and the program outputs a vector of correlated, Gaussian random variables. A variety of random test cases were conducted in two, three and six variables. In each case, the expectation values, variances and covariances were calculated and they converged to the input values. The output of the absorber code is a large data set that stores all of the variables for each particle in the distribution. It is impossible to analyze such a large data set by hand, so visualizations and summary statistics had to be developed. The first visualization is a three-dimensional graph that shows the number of each isotope present after each slice of the absorber. A second graph plots any of the six phase space variables against any of the others to see
Modeling the Gamma-Ray Emission in the GALACTIC CENTER with a Fading Cosmic-ray Accelerator
Liu, Ruo-Yu; Wang, Xiang-Yu; Prosekin, Anton; Chang, Xiao-Chuan
2016-12-01
Recent HESS observations of the ∼200 pc scale diffuse gamma-ray emission from the central molecular zone (CMZ) suggest the presence of a PeV cosmic-ray accelerator (PeVatron) located in the inner 10 pc region of the Galactic center. Interestingly, the gamma-ray spectrum of the point-like source (HESS J1745-290) in the Galactic center shows a cutoff at ∼10 TeV, implying a cutoff around 100 TeV in the cosmic-ray proton spectrum. Here we propose that the gamma-ray emission from the inner and the outer regions may be explained self-consistently by run-away protons from a single yet fading accelerator. In this model, gamma-rays from the CMZ region are produced by protons injected in the past, while gamma-rays from the inner region are produced by protons injected more recently. We suggest that the blast wave formed in a tidal disruption event (TDE) caused by the supermassive black hole (Sgr A*) could serve as such a fading accelerator. With typical parameters of the TDE blast wave, gamma-ray spectra of both the CMZ region and HESS J1745-290 can be reproduced simultaneously. Meanwhile, we find that the cosmic-ray energy density profile in the CMZ region may also be reproduced in the fading accelerator model when appropriate combinations of the particle injection history and the diffusion coefficient of cosmic rays are adopted.
Mischna, Michael A
2016-01-01
We employ the MarsWRF general circulation model (GCM) to test the predictions of a new physical hypothesis: a weak coupling of the orbital and rotational angular momenta of extended bodies is predicted to give rise to cycles of intensification and relaxation of circulatory flows within atmospheres. The dynamical core of the GCM has been modified to include the orbit-spin coupling accelerations due to solar system dynamics for the years 1920-2030. The modified GCM is first subjected to extensive testing and validation. We compare forced and unforced model outcomes for large-scale zonal and meridional flows, and for near-surface wind velocities and surface wind stresses. The predicted cycles of circulatory intensification and relaxation within the modified GCM are observed. Most remarkably, the modified GCM reproduces conditions favorable for the occurrence of perihelion-season global-scale dust storms on Mars in years in which such storms were observed. A strengthening of the meridional overturning (Hadley) ci...
Shi, Yu; Liang, Long; Ge, Hai-Wen; Reitz, Rolf D.
2010-03-01
Acceleration of the chemistry solver for engine combustion is of much interest due to the fact that in practical engine simulations extensive computational time is spent solving the fuel oxidation and emission formation chemistry. A dynamic adaptive chemistry (DAC) scheme based on a directed relation graph error propagation (DRGEP) method has been applied to study homogeneous charge compression ignition (HCCI) engine combustion with detailed chemistry (over 500 species) previously using an R-value-based breadth-first search (RBFS) algorithm, which significantly reduced computational times (by as much as 30-fold). The present paper extends the use of this on-the-fly kinetic mechanism reduction scheme to model combustion in direct-injection (DI) engines. It was found that the DAC scheme becomes less efficient when applied to DI engine simulations using a kinetic mechanism of relatively small size and the accuracy of the original DAC scheme decreases for conventional non-premixed combustion engine. The present study also focuses on determination of search-initiating species, involvement of the NOx chemistry, selection of a proper error tolerance, as well as treatment of the interaction of chemical heat release and the fuel spray. Both the DAC schemes were integrated into the ERC KIVA-3v2 code, and simulations were conducted to compare the two schemes. In general, the present DAC scheme has better efficiency and similar accuracy compared to the previous DAC scheme. The efficiency depends on the size of the chemical kinetics mechanism used and the engine operating conditions. For cases using a small n-heptane kinetic mechanism of 34 species, 30% of the computational time is saved, and 50% for a larger n-heptane kinetic mechanism of 61 species. The paper also demonstrates that by combining the present DAC scheme with an adaptive multi-grid chemistry (AMC) solver, it is feasible to simulate a direct-injection engine using a detailed n-heptane mechanism with 543 species
Lee, Jae-Hwan; Lee, Myeongho; Ahn, Changhwan; Kang, Hee Young; Tran, Dinh Nam; Jeung, Eui-Bae
2017-02-08
Parabens are widely used preservatives in basic necessities such as cosmetic and pharmaceutical products. In previous studies, xenoestrogenic actions of parabens were reported in an immature rat model and a rat pituitary cell line (GH3 cells). The relationship between parabens and ovarian failure has not been described. In the present study, the influence of parabens on ovarian folliculogenesis and steroidogenesis was investigated. A disruptor of ovarian small pre-antral follicles, 4-vinylcyclohexene diepoxide (VCD, 40 mg/kg), was used to induce premature ovarian failure (POF). Methylparaben (MP, 100 mg/kg), propylparaben (PP, 100 mg/kg), and butylparaben (BP, 100 mg/kg) dissolved in corn oil were treated in female 8-week-old Sprague-Dawley rat for 5 weeks. Estrus cycle status was checked daily by vaginal smear test. Ovarian follicle development and steroid synthesis were investigated through real-time PCR and histological analyses. Diestrus phases in the VCD, PP, and BP groups were longer than that in the vehicle group. VCD significantly decreased mRNA level of folliculogenesis-related genes (Foxl2, Kitl and Amh). All parabens significantly increased the Amh mRNA level but unchanged Foxl2 and Kitlg acting in primordial follicles. VCD and MP slightly increased Star and Cyp11a1 levels, which are related to an initial step in steroidogenesis. VCD and parabens induced an increase in FSH levels in serum and significantly decreased the total number of follicles. Increased FSH implies impairment in ovarian function due to VCD or parabens. These results suggest that VCD may suppress both formation and development of follicles. In particular, combined administration of VCD and parabens accelerated inhibition of the follicle-developmental process through elevated AMH level in small antral follicles.
Werner, Liliana; Abdel-Aziz, Salwa; Peck, Carolee Cutler; Monson, Bryan; Espandar, Ladan; Zaugg, Brian; Stringham, Jack; Wilcox, Chris; Mamalis, Nick
2011-01-01
PURPOSE To assess the long-term biocompatibility and photochromic stability of a new photochromic hydrophobic acrylic intraocular lens (IOL) under extended ultraviolet (UV) light exposure. SETTING John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN Experimental study. METHODS A Matrix Aurium photochromic IOL was implanted in right eyes and a Matrix Acrylic IOL without photochromic properties (n = 6) or a single-piece AcrySof Natural SN60AT (N = 5) IOL in left eyes of 11 New Zealand rabbits. The rabbits were exposed to a UV light source of 5 mW/cm2 for 3 hours during every 8-hour period, equivalent to 9 hours a day, and followed for up to 12 months. The photochromic changes were evaluated during slitlamp examination by shining a penlight UV source in the right eye. After the rabbits were humanely killed and the eyes enucleated, study and control IOLs were explanted and evaluated in vitro on UV exposure and studied histopathologically. RESULTS The photochromic IOL was as biocompatible as the control IOLs after 12 months under conditions simulating at least 20 years of UV exposure. In vitro evaluation confirmed the retained optical properties, with photochromic changes observed within 7 seconds of UV exposure. The rabbit eyes had clinical and histopathological changes expected in this model with a 12-month follow-up. CONCLUSIONS The new photochromic IOL turned yellow only on exposure to UV light. The photochromic changes were reversible, reproducible, and stable over time. The IOL was biocompatible with up to 12 months of accelerated UV exposure simulation. PMID:21241924
Lee, Jae-Hwan; Lee, Myeongho; Ahn, Changhwan; Kang, Hee Young; Tran, Dinh Nam; Jeung, Eui-Bae
2017-01-01
Parabens are widely used preservatives in basic necessities such as cosmetic and pharmaceutical products. In previous studies, xenoestrogenic actions of parabens were reported in an immature rat model and a rat pituitary cell line (GH3 cells). The relationship between parabens and ovarian failure has not been described. In the present study, the influence of parabens on ovarian folliculogenesis and steroidogenesis was investigated. A disruptor of ovarian small pre-antral follicles, 4-vinylcyclohexene diepoxide (VCD, 40 mg/kg), was used to induce premature ovarian failure (POF). Methylparaben (MP, 100 mg/kg), propylparaben (PP, 100 mg/kg), and butylparaben (BP, 100 mg/kg) dissolved in corn oil were treated in female 8-week-old Sprague-Dawley rat for 5 weeks. Estrus cycle status was checked daily by vaginal smear test. Ovarian follicle development and steroid synthesis were investigated through real-time PCR and histological analyses. Diestrus phases in the VCD, PP, and BP groups were longer than that in the vehicle group. VCD significantly decreased mRNA level of folliculogenesis-related genes (Foxl2, Kitl and Amh). All parabens significantly increased the Amh mRNA level but unchanged Foxl2 and Kitlg acting in primordial follicles. VCD and MP slightly increased Star and Cyp11a1 levels, which are related to an initial step in steroidogenesis. VCD and parabens induced an increase in FSH levels in serum and significantly decreased the total number of follicles. Increased FSH implies impairment in ovarian function due to VCD or parabens. These results suggest that VCD may suppress both formation and development of follicles. In particular, combined administration of VCD and parabens accelerated inhibition of the follicle-developmental process through elevated AMH level in small antral follicles. PMID:28208728
Kawakami, Koji; Kawakami, Mariko; Puri, Raj K
2004-08-01
Receptors for interleukin-13 (IL-13R) are overexpressed on several types of solid cancers including gliobastoma, renal cell carcinoma, AIDS Kaposi's sarcoma, and head and neck cancer. Recombinant fusion proteins IL-13 cytotoxin (IL13-PE38QQR or IL13-PE38) have been developed to directly target IL-13R-expressing cancer cells. Although it has been found that IL-13 cytotoxin has a direct potent antitumor activity in vivo in nude mice models of human cancers, the involvement of indirect antitumor effecter molecules such as nitric oxide (NO) is unknown. To address this issue, we assessed the effect of NO inhibiter N(omega)-monomethyl-l-arginine on IL-13 cytotoxin-mediated cytotoxicity and NO2/NO3 production in HN12 head and neck cancer cells. In addition, antitumor effects and NO levels in HN12 and KCCT873 head and neck tumors xenografted s.c. in nude mice when treated with IL-13 cytotoxin were evaluated by tumor measurement, Western blot, and immunohistochemistry analyses. Pretreatment of animals with N(omega)-monomethyl-l-arginine significantly decreased the NO levels and IL-13 cytotoxin-mediated antitumor effects. In addition, depletion of macrophages, known to produce NO, also decreased antitumor activity of IL-13 cytotoxin. Based on these studies, we concluded that NO accelerates antitumor effect of IL-13 cytotoxin on head and neck tumor cells. Because IL-13 cytotoxin is currently being tested in the clinic for the treatment of patients with recurrent glioblastoma maltiforme, our current findings suggest maintaining macrophage and NO-producing cellular function for optimal therapeutic effect of this targeted agent.
Jae-Hwan Lee
2017-02-01
Full Text Available Parabens are widely used preservatives in basic necessities such as cosmetic and pharmaceutical products. In previous studies, xenoestrogenic actions of parabens were reported in an immature rat model and a rat pituitary cell line (GH3 cells. The relationship between parabens and ovarian failure has not been described. In the present study, the influence of parabens on ovarian folliculogenesis and steroidogenesis was investigated. A disruptor of ovarian small pre-antral follicles, 4-vinylcyclohexene diepoxide (VCD, 40 mg/kg, was used to induce premature ovarian failure (POF. Methylparaben (MP, 100 mg/kg, propylparaben (PP, 100 mg/kg, and butylparaben (BP, 100 mg/kg dissolved in corn oil were treated in female 8-week-old Sprague-Dawley rat for 5 weeks. Estrus cycle status was checked daily by vaginal smear test. Ovarian follicle development and steroid synthesis were investigated through real-time PCR and histological analyses. Diestrus phases in the VCD, PP, and BP groups were longer than that in the vehicle group. VCD significantly decreased mRNA level of folliculogenesis-related genes (Foxl2, Kitl and Amh. All parabens significantly increased the Amh mRNA level but unchanged Foxl2 and Kitlg acting in primordial follicles. VCD and MP slightly increased Star and Cyp11a1 levels, which are related to an initial step in steroidogenesis. VCD and parabens induced an increase in FSH levels in serum and significantly decreased the total number of follicles. Increased FSH implies impairment in ovarian function due to VCD or parabens. These results suggest that VCD may suppress both formation and development of follicles. In particular, combined administration of VCD and parabens accelerated inhibition of the follicle-developmental process through elevated AMH level in small antral follicles.
Classifying sows' activity types from acceleration patterns
Cornou, Cecile; Lundbye-Christensen, Søren
2008-01-01
-dimensional axes, plus the length of the acceleration vector) are selected for each activity. Each time series is modeled using a Dynamic Linear Model with cyclic components. The classification method, based on a Multi-Process Kalman Filter (MPKF), is applied to a total of 15 times series of 120 observations......An automated method of classifying sow activity using acceleration measurements would allow the individual sow's behavior to be monitored throughout the reproductive cycle; applications for detecting behaviors characteristic of estrus and farrowing or to monitor illness and welfare can be foreseen....... This article suggests a method of classifying five types of activity exhibited by group-housed sows. The method involves the measurement of acceleration in three dimensions. The five activities are: feeding, walking, rooting, lying laterally and lying sternally. Four time series of acceleration (the three...
Diffusive Acceleration of Ions at Interplanetary Shocks
Baring, M G; Baring, Matthew G.; Summerlin, Errol J.
2005-01-01
Heliospheric shocks are excellent systems for testing theories of particle acceleration in their environs. These generally fall into two classes: (1) interplanetary shocks that are linear in their ion acceleration characteristics, with the non-thermal ions serving as test particles, and (2) non-linear systems such as the Earth's bow shock and the solar wind termination shock, where the accelerated ions strongly influence the magnetohydrodynamic structure of the shock. This paper explores the modelling of diffusive acceleration at a particular interplanetary shock, with an emphasis on explaining in situ measurements of ion distribution functions. The observational data for this event was acquired on day 292 of 1991 by the Ulysses mission. The modeling is performed using a well-known kinetic Monte Carlo simulation, which has yielded good agreement with observations at several heliospheric shocks, as have other theoretical techniques, namely hybrid plasma simulations, and numerical solution of the diffusion-conv...
Casademunt, Jaume; Zhang, Wenbin; Vinals, Jorge; Sekerka, Robert F.
1993-01-01
We introduce a stochastic model to analyze in quantitative detail the effect of the high frequency components of the residual accelerations onboard spacecraft (often called g-jitter) on fluid motion. The residual acceleration field is modeled as a narrow band noise characterized by three independent parameters: its intensity G squared, a dominant frequency Omega, and a characteristic spectral width tau exp -1. The white noise limit corresponds to Omega tau goes to O, with G squared tau finite, and the limit of a periodic g-jitter (or deterministic limit) can be recovered for Omega tau goes to infinity, G squared finite. The analysis of the response of a fluid surface subjected to a fluctuating gravitational field leads to the stochastic Mathieu equation driven by both additive and multiplicative noise. We discuss the stability of the solutions of this equation in the two limits of white noise and deterministic forcing, and in the general case of narrow band noise. The results are then applied to typical microgravity conditions.
Mu, Bingnan; Xu, Helan; Yang, Yiqi
2015-11-01
In this work, kinetics of substitution accelerated cellulose hydrolysis with multiple reaction stages was investigated to lay foundation for mechanism study and molecular design of substituting compounds. High-efficiency hydrolysis of cellulose is critical for cellulose-based bioethanol production. It is known that, substitution could substantially decrease activation energy and increase reaction rate of acidic hydrolysis of glycosidic bonds in cellulose. However, reaction kinetics and mechanism of the accelerated hydrolysis were not fully revealed. In this research, it was proved that substitution therefore accelerated hydrolysis only occurred in amorphous regions of cellulose fibers, and was a process with multiple reaction stages. With molar ratio of substitution less than 1%, the overall hydrolysis rate could be increased for around 10 times. We also quantified the relationship between the hydrolysis rate of individual reaction stage and its major influences, including molar ratio of substitution, activation energy of acidic hydrolysis, pH and temperature. Copyright © 2015 Elsevier Ltd. All rights reserved.
Vlasov modelling of laser-driven collisionless shock acceleration of protons
Svedung Wettervik, B.; DuBois, T. C.; Fülöp, T. [Department of Applied Physics, Chalmers University of Technology, Gothenburg (Sweden)
2016-05-15
Ion acceleration due to the interaction between a short high-intensity laser pulse and a moderately overdense plasma target is studied using Eulerian Vlasov–Maxwell simulations. The effects of variations in the plasma density profile and laser pulse parameters are investigated, and the interplay of collisionless shock and target normal sheath acceleration is analyzed. It is shown that the use of a layered-target with a combination of light and heavy ions, on the front and rear side, respectively, yields a strong quasi-static sheath-field on the rear side of the heavy-ion part of the target. This sheath-field increases the energy of the shock-accelerated ions while preserving their mono-energeticity.
Characteristics of the Receptor for the Biosphere Model
M.A. Wasiolek
2005-04-05
This analysis report is one of a series of technical reports that document the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the geologic repository at Yucca Mountain. This report is one of the five biosphere reports that develop input parameter values for the biosphere model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes the conceptual model, as well as the mathematical model and its input parameters. Figure 1-1 is a graphical representation of the documentation hierarchy for the ERMYN. This figure shows relationships among the products (i.e., scientific analyses and model reports) developed for biosphere modeling and biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan for Biosphere Modeling and Expert Support'' (BSC 2005 [DIRS 172782]). The purpose of this analysis report is to define values for biosphere model parameters that are related to the dietary, lifestyle, and dosimetric characteristics of the receptor. The biosphere model, consistent with the licensing rule at 10 CFR Part 63 [DIRS 173164], uses a hypothetical person called the reasonably maximally exposed individual (RMEI) to represent the potentially exposed population. The parameters that define the RMEI are based on the behaviors and characteristics of the residents of the unincorporated town of Amargosa Valley, consistent with the requirements of 10 CFR 63.312 [DIRS 173164]. The output of this report is used as direct input in the two analyses identified in Figure 1-1 that calculate the values of biosphere dose conversion factors (BDCFs) for the groundwater and volcanic ash exposure scenarios. The parameter values developed in this report are reflected in the TSPA through the BDCFs. The analysis was performed in accordance with LP-SIII.9Q-BSC, ''Scientific Analyses'', and the technical work
Effenberger, F.; Petrosian, V.
2015-12-01
Stochastic acceleration scenarios are among the most promising candidates to explain the high energies attained by particles in solar flares. Recent progress in the determination of fundamental acceleration parameters using novel techniques for the inversion of high resolution RHESSI hard X-ray spectra allows to determine non-thermal electron spectra at the loop top and foot points of a flare loop (Chen & Petrosian 2014). One outcome of this work is that the trapping and escape of the electrons is governed by wave particle scatterings and convergence of magnetic lines of force. Here, we present a computational study of the transport and escape processes of particles in the acceleration region. We employ a Fokker-Planck model, which includes pitch-angle scattering and magnetic mirroring in a non-uniform magnetic field. This allows to test analytical approximations for the particle escape times in the loop top region, which are helpful to constrain the key particle acceleration parameters. New perspectives will be given on how the insights gained from the analysis of the particle confinement will enable subsequent studies of a broader class of solar flares.
Neveu, N.; Larson, J.; Power, J. G.; Spentzouris, L.
2017-07-01
Model-based, derivative-free, trust-region algorithms are increasingly popular for optimizing computationally expensive numerical simulations. A strength of such methods is their efficient use of function evaluations. In this paper, we use one such algorithm to optimize the beam dynamics in two cases of interest at the Argonne Wakefield Accelerator (AWA) facility. First, we minimize the emittance of a 1 nC electron bunch produced by the AWA rf photocathode gun by adjusting three parameters: rf gun phase, solenoid strength, and laser radius. The algorithm converges to a set of parameters that yield an emittance of 1.08 μm. Second, we expand the number of optimization parameters to model the complete AWA rf photoinjector (the gun and six accelerating cavities) at 40 nC. The optimization algorithm is used in a Pareto study that compares the trade-off between emittance and bunch length for the AWA 70MeV photoinjector.
Femi-type acceleration of electron in γ-ray burst fireball model
无
2001-01-01
We calculate numerically the hydrodynamic evolution of a γ-ray burst fireball. The results show that refluence will emerge during fireball expansion due to negative-pressure effect. The refluence will collide with outward fluid, then shock wave will form. Electrons moving between the inward and outward fluid shells can be accelerated to 104—105 MeV by one order Femi-type acceleration with high efficiency after several collisions. Radiation of electrons with such high energy may be the observed γ-ray bursts.
DEVELOPMENT OF POLITICAL PARTIES AND PARTY FUNDING: MODELS AND CHARACTERISTICS
Hrvoje MATAKOVIC
2015-03-01
Full Text Available The first modern political parties were formed at the end of the 18th century and have, from those times up to now, undergone 4 developing phases; each of the phases is bound to ideal-type political party model: cadre parties, mass parties, catch-all parties and cartel parties. Each of these party models differentiates in various characteristics: party foundation, number of members, and way of leading the election campaigns, but also in ways of financing. This paper describes the above mentioned 4 phases of political parties’ development and 4 phases of parties' finances development; it will be analysed in detail positive and negative sides of each of the models of party financing.
GPU-accelerated Modeling and Element-free Reverse-time Migration with Gauss Points Partition
Zhen, Z.; Jia, X.
2014-12-01
Element-free method (EFM) has been applied to seismic modeling and migration. Compared with finite element method (FEM) and finite difference method (FDM), it is much cheaper and more flexible because only the information of the nodes and the boundary of the study area are required in computation. In the EFM, the number of Gauss points should be consistent with the number of model nodes; otherwise the accuracy of the intermediate coefficient matrices would be harmed. Thus when we increase the nodes of velocity model in order to obtain higher resolution, we find that the size of the computer's memory will be a bottleneck. The original EFM can deal with at most 81×81 nodes in the case of 2G memory, as tested by Jia and Hu (2006). In order to solve the problem of storage and computation efficiency, we propose a concept of Gauss points partition (GPP), and utilize the GPUs to improve the computation efficiency. Considering the characteristics of the Gaussian points, the GPP method doesn't influence the propagation of seismic wave in the velocity model. To overcome the time-consuming computation of the stiffness matrix (K) and the mass matrix (M), we also use the GPUs in our computation program. We employ the compressed sparse row (CSR) format to compress the intermediate sparse matrices and try to simplify the operations by solving the linear equations with the CULA Sparse's Conjugate Gradient (CG) solver instead of the linear sparse solver 'PARDISO'. It is observed that our strategy can significantly reduce the computational time of K and Mcompared with the algorithm based on CPU. The model tested is Marmousi model. The length of the model is 7425m and the depth is 2990m. We discretize the model with 595x298 nodes, 300x300 Gauss cells and 3x3 Gauss points in each cell. In contrast to the computational time of the conventional EFM, the GPUs-GPP approach can substantially improve the efficiency. The speedup ratio of time consumption of computing K, M is 120 and the
Ji, Songbai; Zhao, Wei; Li, Zhigang; McAllister, Thomas W
2014-10-01
Both linear [Formula: see text] and rotational [Formula: see text] accelerations contribute to head impacts on the field in contact sports; however, they are often isolated in injury studies. It is critical to evaluate the feasibility of estimating brain responses using isolated instead of full degrees-of-freedom (DOFs) accelerations. In this study, we investigated the sensitivities of regional brain strain-related responses to resultant [Formula: see text] and [Formula: see text] as well as the relative contributions of these acceleration components to the responses via random sampling and linear regression using parameterized, triangulated head impacts with kinematic variable values based on on-field measurements. Two independently established and validated finite element models of the human head were employed to evaluate model-consistency and dependency in results: the Dartmouth Head Injury Model and Simulated Injury Monitor. For the majority of the brain, volume-weighted regional peak strain, strain rate, and von Mises stress accumulated from the simulation significantly correlated with the product of the magnitude and duration of [Formula: see text], or effectively, the rotational velocity, but not to [Formula: see text]. Responses from [Formula: see text]-only were comparable to the full-DOF counterparts especially when normalized by injury-causing thresholds (e.g., volume fractions of large differences virtually diminished (i.e., [Formula: see text]1 %) at typical difference percentage levels of 1-4 % on average). These model-consistent results support the inclusion of both rotational acceleration magnitude and duration into kinematics-based injury metrics and demonstrate the feasibility of estimating strain-related responses from isolated [Formula: see text] for analyses of strain-induced injury relevant to contact sports without significant loss of accuracy, especially for the cerebrum.
Model analysis for combustion characteristics of RDF pellet
无
2002-01-01
Fundamental studies of the combustion characteristics and the de-HCl behavior of a single refuse-derived fuel(RDF) pellet were carried out to explain the de-HCl phenomena of RDF during fluidized bed combustion and to provide data for the development of high efficiency power generation technology using RDF previously. For further interpreting the devolatilization and the char combustion processes of RDF quantitatively, an unsteady combustion model for single RDF pellet, involving reaction rates, heat transfer and oxygen diffusion in the RDF pellet, was developed. Comparisons of simulation results with experimental data for mass loss of the RDF samples made from municipal solid waste, wood chips and poly-propylene when they were heated at 10K/min or put into the furnace under 1073K show the verifiability of the model. Using this model, the distributions of the temperature and the reaction ratio along the radius of RDF pellet during the devolatilization process and the char combustion process were presented, and discussion about the inference of heating rate on the combustion characteristics were performed.
Gedeon, Patrick C; Thomas, James R; Madura, Jeffry D
2015-01-01
Molecular dynamics simulation provides a powerful and accurate method to model protein conformational change, yet timescale limitations often prevent direct assessment of the kinetic properties of interest. A large number of molecular dynamic steps are necessary for rare events to occur, which allow a system to overcome energy barriers and conformationally transition from one potential energy minimum to another. For many proteins, the energy landscape is further complicated by a multitude of potential energy wells, each separated by high free-energy barriers and each potentially representative of a functionally important protein conformation. To overcome these obstacles, accelerated molecular dynamics utilizes a robust bias potential function to simulate the transition between different potential energy minima. This straightforward approach more efficiently samples conformational space in comparison to classical molecular dynamics simulation, does not require advanced knowledge of the potential energy landscape and converges to the proper canonical distribution. Here, we review the theory behind accelerated molecular dynamics and discuss the approach in the context of modeling protein conformational change. As a practical example, we provide a detailed, step-by-step explanation of how to perform an accelerated molecular dynamics simulation using a model neurotransmitter transporter embedded in a lipid cell membrane. Changes in protein conformation of relevance to the substrate transport cycle are then examined using principle component analysis.
2013-07-29
stepping integrator for finite-Larmor radius particle trajectories, accelerated collisional-radiative non -equilibrium ionization kinetics through...Reproduces 3-4 Orders of Magnitude Random Merge -> Thermalization 3000 First Point, 1500 First Cross Bi- Maxwellian Specifically Difficult Octree Merge...Merge -> Thermalization 3000 First Point, 1500 First Cross Bi- Maxwellian Specifically Difficult Octree Merge Significantly Better Merge & Split Adapts
Buford, Thomas W.; Anton, Stephen D.; Judge, Andrew R.; Marzetti, Emanuele; Wohlgemuth, Stephanie E; Carter, Christy S.; Leeuwenburgh, Christiaan; Pahor, Marco; Manini, Todd M.
2013-01-01
Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population ages. Certain conditions have the strong potential to coincide with sarcopenia to accelerate the progression of muscle atrophy in older adults. Among these conditions are co-morbid diseases common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease. Furthermore, behaviors such as poor nutrition and physical inactivity are well-known to contribute to sarcopenia development. However, we argue that these behaviors are not inherent to the development of sarcopenia but rather accelerate its progression. In the present review, we discuss how these factors affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy. In addition, we describe gaps in the literature concerning the role of these factors in accelerating sarcopenia progression. Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia. PMID:20438881
Synaptic proteome changes in a DNA repair deficient Ercc1 mouse model of accelerated aging
M.J. Végh (Marlene); M.C. de Waard (Monique); I. van der Pluijm (Ingrid); Y. Ridwan (Yanto); M.J.M. Sassen (Marion J.); P. van Nierop (Pim); R.C. van der Schors (Roel); K.W. Li (Ka Wan); J.H.J. Hoeijmakers (Jan); A.B. Smit (August); R.E. van Kesteren (Ronald)
2012-01-01
textabstractCognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here we used Ercc1 mutant mice, which are impaired in multiple DNA repair systems and consequently show accelerated aging and progressive memory deficits, to identify changes in the levels of
Anandarajah Gabrial
2009-07-01
Full Text Available Abstract Background This work explores the potential contribution of bioenergy technologies to 60% and 80% carbon reductions in the UK energy system by 2050, by outlining the potential for accelerated technological development of bioenergy chains. The investigation was based on insights from MARKAL modelling, detailed literature reviews and expert consultations. Due to the number and complexity of bioenergy pathways and technologies in the model, three chains and two underpinning technologies were selected for detailed investigation: (1 lignocellulosic hydrolysis for the production of bioethanol, (2 gasification technologies for heat and power, (3 fast pyrolysis of biomass for bio-oil production, (4 biotechnological advances for second generation bioenergy crops, and (5 the development of agro-machinery for growing and harvesting bioenergy crops. Detailed literature searches and expert consultations (looking inter alia at research and development needs and economic projections led to the development of an 'accelerated' dataset of modelling parameters for each of the selected bioenergy pathways, which were included in five different scenario runs with UK-MARKAL (MED. The results of the 'accelerated runs' were compared with a low-carbon (LC-Core scenario, which assesses the cheapest way to decarbonise the energy sector. Results Bioenergy was deployed in larger quantities in the bioenergy accelerated technological development scenario compared with the LC-Core scenario. In the electricity sector, solid biomass was highly utilised for energy crop gasification, displacing some deployment of wind power, and nuclear and marine to a lesser extent. Solid biomass was also deployed for heat in the residential sector from 2040 in much higher quantities in the bioenergy accelerated technological development scenario compared with LC-Core. Although lignocellulosic ethanol increased, overall ethanol decreased in the transport sector in the bioenergy
Modelling Ecuador's rainfall distribution according to geographical characteristics.
Tobar, Vladimiro; Wyseure, Guido
2017-04-01
It is known that rainfall is affected by terrain characteristics and some studies had focussed on its distribution over complex terrain. Ecuador's temporal and spatial rainfall distribution is affected by its location on the ITCZ, the marine currents in the Pacific, the Amazon rainforest, and the Andes mountain range. Although all these factors are important, we think that the latter one may hold a key for modelling spatial and temporal distribution of rainfall. The study considered 30 years of monthly data from 319 rainfall stations having at least 10 years of data available. The relatively low density of stations and their location in accessible sites near to main roads or rivers, leave large and important areas ungauged, making it not appropriate to rely on traditional interpolation techniques to estimate regional rainfall for water balance. The aim of this research was to come up with a useful model for seasonal rainfall distribution in Ecuador based on geographical characteristics to allow its spatial generalization. The target for modelling was the seasonal rainfall, characterized by nine percentiles for each one of the 12 months of the year that results in 108 response variables, later on reduced to four principal components comprising 94% of the total variability. Predictor variables for the model were: geographic coordinates, elevation, main wind effects from the Amazon and Coast, Valley and Hill indexes, and average and maximum elevation above the selected rainfall station to the east and to the west, for each one of 18 directions (50-135°, by 5°) adding up to 79 predictors. A multiple linear regression model by the Elastic-net algorithm with cross-validation was applied for each one of the PC as response to select the most important ones from the 79 predictor variables. The Elastic-net algorithm deals well with collinearity problems, while allowing variable selection in a blended approach between the Ridge and Lasso regression. The model fitting
Hagiwara, T.; Funabashi, T.; Watanabe, H.; Takeuchi, N. [Meidensha Corporation, Tokyo (Japan); Ueda, T. [Chubu Electric Power Co. Inc., Nagoya (Japan)
1996-11-20
Generally a model of Metal Oxide Surge Arrester (MOSA) for numerical analysis uses a non-linear resistance. But actual Voltage-Current (V-I) characteristics of MOSA have hysteresis loop in time domain like i-{Phi} characteristic of a transformer and frequency dependency. The authors have investigated relation between the actual V-I hysteresis characteristics obtained by some current waveforms and static V-I characteristics. From the voltage difference between above two characteristics, an equation was derived and a new model of MOSA was developed. This model consists of a non-linear resistance representing fundamental V-I characteristic, a linear inductance and voltage source which depends on the absorbed energy. The calculated results by the proposed model are compared with measurement results by using the waveform of standard impulse current, steep front current and oscillated current. And the accuracy of the model has been confirmed to be satisfactory. The model is expected to be useful to investigate insulation coordination of power systems. 11 refs., 11 figs., 2 tabs.
Abe, Yota; Sugaya, Tomoaki; Sakamoto, Masaaki
2014-06-01
[Purpose] This study aimed to investigate the postural control characteristics of individuals with and without a history of ankle sprain during single-leg standing by examining the relationship between various parameters of center of pressure (COP) and head and foot acceleration. [Subjects] Twenty subjects with and 23 subjects without a history of ankle sprain (sprain and control groups, respectively) participated. [Methods] Mean and maximum COP velocity and maximum COP range in the anteroposterior and mediolateral components of movement were calculated using a gravicorder. The anteroposterior and mediolateral maximum accelerations of the head and foot, as well as the root mean square (RMS) of each acceleration parameter, were measured using accelerometers. [Results] In the mediolateral component, a significant positive correlation was found between maximum acceleration of the foot and all COP parameters in the sprain group. [Conclusion] Our findings suggest that mediolateral momentary motion of the foot in individuals with a history of ankle sprain has relevance to various parameters of COP.
Advanced 3D Poisson solvers and particle-in-cell methods for accelerator modeling
Serafini, David B; McCorquodale, Peter; Colella, Phillip [Lawrence Berkeley National Lab, Applied Numerical Algorithms Group, SciDAC Applied Differential Equations Center (United States)
2005-01-01
We seek to improve on the conventional FFT-based algorithms for solving the Poisson equation with infinite-domain (open) boundary conditions for large problems in accelerator modeling and related areas. In particular, improvements in both accuracy and performance are possible by combining several technologies: the method of local corrections (MLC); the James algorithm; and adaptive mesh refinement (AMR). The MLC enables the parallelization (by domain decomposition) of problems with large domains and many grid points. This improves on the FFT-based Poisson solvers typically used as it doesn't require the all-to-all communication pattern that parallel 3d FFT algorithms require, which tends to be a performance bottleneck on current (and foreseeable) parallel computers. In initial tests, good scalability up to 1000 processors has been demonstrated for our new MLC solver. An essential component of our approach is a new version of the James algorithm for infinite-domain boundary conditions for the case of three dimensions. By using a simplified version of the fast multipole method in the boundary-to-boundary potential calculation, we improve on the performance of the Hockney algorithm typically used by reducing the number of grid points by a factor of 8, and the CPU costs by a factor of 3. This is particularly important for large problems where computer memory limits are a consideration. The MLC allows for the use of adaptive mesh refinement, which reduces the number of grid points and increases the accuracy in the Poisson solution. This improves on the uniform grid methods typically used in PIC codes, particularly in beam problems where the halo is large. Also, the number of particles per cell can be controlled more closely with adaptivity than with a uniform grid. To use AMR with particles is more complicated than using uniform grids. It affects depositing particles on the non-uniform grid, reassigning particles when the adaptive grid changes and maintaining the
Characteristics of Behavior of Robots with Emotion Model
Sato, Shigehiko; Nozawa, Akio; Ide, Hideto
Cooperated multi robots system has much dominance in comparison with single robot system. It is able to adapt to various circumstances and has a flexibility for variation of tasks. However it has still problems to control each robot, though methods for control multi robots system have been studied. Recently, the robots have been coming into real scene. And emotion and sensitivity of the robots have been widely studied. In this study, human emotion model based on psychological interaction was adapt to multi robots system to achieve methods for organization of multi robots. The characteristics of behavior of multi robots system achieved through computer simulation were analyzed. As a result, very complexed and interesting behavior was emerged even though it has rather simple configuration. And it has flexiblity in various circumstances. Additional experiment with actual robots will be conducted based on the emotion model.
Zhang Chao
2015-12-01
Full Text Available Harmonic drives have various distinctive advantages and are widely used in space drive mechanisms. Accelerated life test (ALT is commonly conducted to shorten test time and reduce associated costs. An appropriate ALT model is needed to predict the lifetime of harmonic drives with ALT data. However, harmonic drives which are used in space usually work under a segmental stress history, and traditional ALT models can hardly be used in this situation. This paper proposes a dedicated ALT model for harmonic drives applied in space systems. A comprehensive ALT model is established and genetic algorithm (GA is adopted to obtain optimal parameters in the model using the Manson fatigue damage rule to describe the fatigue failure process and a cumulative damage method to calculate and accumulate the damage caused by each segment in the stress history. An ALT of harmonic drives was carried out and experimental results show that this model is acceptable and effective.
Zhang Chao; Wang Shaoping; Wang Zimeng; Wang Xingjian
2015-01-01
Harmonic drives have various distinctive advantages and are widely used in space drive mechanisms. Accelerated life test (ALT) is commonly conducted to shorten test time and reduce associated costs. An appropriate ALT model is needed to predict the lifetime of harmonic drives with ALT data. However, harmonic drives which are used in space usually work under a segmental stress history, and traditional ALT models can hardly be used in this situation. This paper proposes a dedicated ALT model for harmonic drives applied in space systems. A comprehensive ALT model is established and genetic algorithm (GA) is adopted to obtain optimal parameters in the model using the Manson fatigue damage rule to describe the fatigue failure process and a cumulative dam-age method to calculate and accumulate the damage caused by each segment in the stress history. An ALT of harmonic drives was carried out and experimental results show that this model is acceptable and effective.
John Womersley
2003-08-21
I describe the future accelerator facilities that are currently foreseen for electroweak scale physics, neutrino physics, and nuclear structure. I will explore the physics justification for these machines, and suggest how the case for future accelerators can be made.
Research on vibration characteristics of gun barrel based on contact model
Zhao, Yang; Zhou, Qizheng; Yue, Pengfei
2017-04-01
In order to study vibration characteristics of the gun barrel under the action of moving projectile, the gun barrel is simplified to cross sectional cantilever beam such as Euler. Considering contact conditions of inertia effect and projectile with the gun barrel, the equation of lateral vibration of the gun barrel is established under the projectile-gun coupling effect; the modal analysis method is used to give the analytic solutions of equation series. The effect of the motion parameters the projectile on the vibration of gun barrel is discussed, and characteristics of vibration of gun barrel are further studied under two conditions of repeating and projectile with mass eccentricity. The research results show that reasonable control of the acceleration of the projectile in the gun bore, and reduction of projectile mass eccentricity can help reduce the muzzle vibration at the gun firing. The research results can provide reference for overall design of the gun, and the modeling and analysis method used in the paper can be promoted for the solution of vibration of other related projects under the moving excitation.
Characteristics of successful opinion leaders in a bounded confidence model
Chen, Shuwei; Glass, David H.; McCartney, Mark
2016-05-01
This paper analyses the impact of competing opinion leaders on attracting followers in a social group based on a bounded confidence model in terms of four characteristics: reputation, stubbornness, appeal and extremeness. In the model, reputation differs among leaders and normal agents based on the weights assigned to them, stubbornness of leaders is reflected by their confidence towards normal agents, appeal of the leaders is represented by the confidence of followers towards them, and extremeness is captured by the opinion values of leaders. Simulations show that increasing reputation, stubbornness or extremeness makes it more difficult for the group to achieve consensus, but increasing the appeal will make it easier. The results demonstrate that successful opinion leaders should generally be less stubborn, have greater appeal and be less extreme in order to attract more followers in a competing environment. Furthermore, the number of followers can be very sensitive to small changes in these characteristics. On the other hand, reputation has a more complicated impact: higher reputation helps the leader to attract more followers when the group bound of confidence is high, but can hinder the leader from attracting followers when the group bound of confidence is low.
"Leading blob" model in a stochastic acceleration scenario: the case of the 2009 flare of Mkn~501
Lefa, E; Rieger, F M
2011-01-01
Evidence for very hard, intrinsic $\\gamma$-ray source spectra, as inferred after correction for absorption in the extragalactic background light (EBL), has interesting implications for the acceleration and radiation mechanisms acting in blazars. A key issue so far has been the dependance of the hardness of the $\\gamma$-ray spectrum on different existing EBL models. The recent {\\it Fermi} observations of Mkn~501 now provide additional evidence for the presence of hard intrinsic $\\gamma$-ray spectra independent of EBL uncertainties. Relativistic Maxwellian-type electron energy distributions that are formed in stochastic acceleration scenarios offer a plausible interpretation for such hard source spectra. Here we show that the combined emission from different components with Maxwellian-type distributions could in principle also account for more softer and broader, power law-like emission spectra. We introduce a "leading blob" scenario, applicable to active flaring episodes, when one (or few) of these components ...
Bochenkov, Vladimir; Suetin, Nikolay; Shankar, Sadasivan
2014-09-07
A new method, the Extended Temperature-Accelerated Dynamics (XTAD), is introduced for modeling long-timescale evolution of large rare-event systems. The method is based on the Temperature-Accelerated Dynamics approach [M. Sørensen and A. Voter, J. Chem. Phys. 112, 9599 (2000)], but uses full-scale parallel molecular dynamics simulations to probe a potential energy surface of an entire system, combined with the adaptive on-the-fly system decomposition for analyzing the energetics of rare events. The method removes limitations on a feasible system size and enables to handle simultaneous diffusion events, including both large-scale concerted and local transitions. Due to the intrinsically parallel algorithm, XTAD not only allows studies of various diffusion mechanisms in solid state physics, but also opens the avenue for atomistic simulations of a range of technologically relevant processes in material science, such as thin film growth on nano- and microstructured surfaces.
Louis Trudel
2016-06-01
Full Text Available This exploratory study intends to model kinematics learning of a pair of student teachers when exposed to prescribed teaching strategies in a video-based laboratory. Two student teachers were chosen from the Francophone B.Ed. program of the Faculty of Education of a Canadian university. The study method consisted of having the participants interact with a video-based laboratory to complete two activities for learning properties of acceleration in rectilinear motion. Time limits were placed on the learning activities during which the researcher collected detailed multimodal information from the student teachers' answers to questions, the graphs they produced from experimental data, and the videos taken during the learning sessions. As a result, we describe the learning approach each one followed, the evidence of conceptual change and the difficulties they face in tackling various aspects of the accelerated motion. We then specify advantages and limits of our research and propose recommendations for further study.
CFT Duals for Accelerating Black Holes
Astorino, Marco
2016-01-01
The near horizon geometry of the rotating C-metric, describing accelerating Kerr-Newman black holes, is analysed. It is shown that, at extremality, even though not it is isomorphic to the extremal Kerr-Newman, it remains a warped and twisted product of $AdS_2 \\times S^2$. Therefore the methods of the Kerr/CFT correspondence can successfully be applied to build a CFT dual model, whose entropy reproduce, through the Cardy formula, the Beckenstein-Hawking entropy of the accelerating black hole. The mass of accelerating Kerr-Newman black hole, which fulfil the first law of thermodynamics, is presented. Further generalisation in presence of an external Melvin-like magnetic field, used to regularise the conical singularity characteristic of the C-metrics, shows that the Kerr/CFT correspondence can be applied also for the accelerating and magnetised extremal black holes.
CFT duals for accelerating black holes
Astorino, Marco
2016-09-01
The near horizon geometry of the rotating C-metric, describing accelerating Kerr-Newman black holes, is analysed. It is shown that, at extremality, even though it is not isomorphic to the extremal Kerr-Newman, it remains a warped and twisted product of AdS2 ×S2. Therefore the methods of the Kerr/CFT correspondence can successfully be applied to build a CFT dual model, whose entropy reproduces, through the Cardy formula, the Bekenstein-Hawking entropy of the accelerating black hole. The mass of accelerating Kerr-Newman black hole, which fulfils the first law of thermodynamics, is presented. Further generalisation in presence of an external Melvin-like magnetic field, used to regularise the conical singularity characteristic of the C-metrics, shows that the Kerr/CFT correspondence can be applied also for the accelerating and magnetised extremal black holes.
Two-Step Acceleration Model of Cosmic Rays at Middle-Aged SNR
Inoue, Tsuyoshi; Inutsuka, Shu-ichiro
2010-01-01
Recent gamma-ray observations of middle-aged supernova remnants revealed a mysterious broken power-law spectrum. Using three-dimensional magnetohydrodynamics simulations, we show that the interaction between a supernova blast wave and interstellar clouds formed by thermal instability generates multiple reflected shocks. The typical Mach numbers of the reflected shocks are shown to be M ~ 2 depending on the density contrast between the diffuse intercloud gas and clouds. These secondary shocks can further energize cosmic-ray particles originally accelerated at the blast-wave shock. This "two-step" acceleration scenario reproduces the observed gamma-ray spectrum and predicts the high-energy spectral index ranging approximately from 3 to 4.
GPU-Accelerated Finite Element Method for Modelling Light Transport in Diffuse Optical Tomography
Martin Schweiger
2011-01-01
and frequency-domain problems. A comparison with a CPU-based implementation shows significant performance gains of the graphics accelerated solution, with improvements of approximately a factor of 10 for double-precision computations, and factors beyond 20 for single-precision computations. The gains are also shown to be dependent on the mesh complexity, where the largest gains are achieved for high mesh resolutions.
Modelling Beam Dynamics and RF Production in Two Beam Accelerators with a Hybrid Simulation Tool
Lidia, Steven
2000-04-01
A hybrid mapping and PIC code is described and applied to the study of transient-to-steady-state phenomena of beam dynamics and rf power production in relativistic-klystron two-beam accelerators. Beam and beamline parameters appropriate to a single device that produces 40-100 MW per meter over 10 meters with a 120 ns pulse length are described and used.
Experiments assigned to determine the acceleration of 8000kN shear laboratory model elements
Budiul Berghian, A.; Vasiu, T.; Abrudean, C.
2017-01-01
In this paper presents an experimental kinetics study by measuring accelerations using a bi-axial accelerometer constructed in the basis of a miniature integrated circuit, included in the class of micro-electrical and mechanical systems - MMA6261Q on the experimental installation reduced to the 1:5 dividing rule by comparison with the shear existent in exploitation, conceived and projected at the Faculty of Engineering in Hunedoara.
LIU Wen-lin; MU Zhi-tao; JIN Ping
2006-01-01
Based on corrosion damage data of 10 years for a type of aircraft aluminum alloy, the statistical analysis was conducted by Gumbel, Normal and two parameters Weibull distribution function. The results show that aluminum alloy structural member has the corrosion history of pitting corrosion-intergranular corrosion-exfoliation corrosion, and the maximum corrosion depth is in conformity to normal distribution. The accelerated corrosion test was carried out with the complied equivalent airport accelerated environment spectrum. The corrosion damage failure modes of aluminum alloy structural member indicate that the period of validity of the former protective coating is about 2.5 to 3 years, and that of the novel protective coating is about 4.0 to 4.5 years. The corrosion kinetics law of aluminum spar flange was established by fitting corrosion damage test data. The law indicates two apparent corrosion stages of high strength aluminum alloy section material: pitting corrosion and intergranular corrosion/exfoliation corrosion.The test results agree with the statistical fit result of corrosion data collected from corrosion member in service. The fractional error is 5.8% at the same calendar year. The accelerated corrosion test validates the corrosion kinetics law of aircraft aluminum alloy in service.
From tracking code to analysis generalised Courant-Snyder theory for any accelerator model
Forest, Etienne
2016-01-01
This book illustrates a theory well suited to tracking codes, which the author has developed over the years. Tracking codes now play a central role in the design and operation of particle accelerators. The theory is fully explained step by step with equations and actual codes that the reader can compile and run with freely available compilers. In this book, the author pursues a detailed approach based on finite “s”-maps, since this is more natural as long as tracking codes remain at the center of accelerator design. The hierarchical nature of software imposes a hierarchy that puts map-based perturbation theory above any other methods. This is not a personal choice: it follows logically from tracking codes overloaded with a truncated power series algebra package. After defining abstractly and briefly what a tracking code is, the author illustrates most of the accelerator perturbation theory using an actual code: PTC. This book may seem like a manual for PTC; however, the reader is encouraged to explore...
Analytic model and frequency characteristics of plasma synthetic jet actuator
Zong, Hao-hua; Wu, Yun; Li, Ying-hong; Song, Hui-min; Zhang, Zhi-bo; Jia, Min
2015-02-01
This paper reports a novel analytic model of a plasma synthetic jet actuator (PSJA), considering both the heat transfer effect and the inertia of the throat gas. Both the whole cycle characteristics and the repetitive working process of PSJA can be predicted with this model. The frequency characteristics of a PSJA with 87 mm3 volume and different orifice diameters are investigated based on the analytic model combined with experiments. In the repetitive working mode, the actuator works initially in the transitional stage with 20 cycles and then in the dynamic balanced stage. During the transitional stage, major performance parameters of PSJA experience stepped growth, while during the dynamic balanced stage, these parameters are characterized by periodic variation. With a constant discharge energy of 6.9 mJ, there exists a saturated frequency of 4 kHz/6 kHz for an orifice diameter of 1 mm/1.5 mm, at which the time-averaged total pressure of the pulsed jet reaches a maximum. Between 0.5 mm and 1.5 mm, a larger orifice diameter leads to a higher saturated frequency due to the reduced jet duration time. As the actuation frequency increases, both the time-averaged cavity temperature and the peak jet velocity initially increase and then remain almost unchanged at 1600 K and 280 m/s, respectively. Besides, with increasing frequency, the mechanical energy incorporated in single pulsed jet, the expelled mass per pulse, and the time-averaged density in the cavity, decline in a stair stepping way, which is caused by the intermittent decrease of refresh stage duration in one period.
Ishak, Mustapha; Troxel, M A
2013-01-01
Probes of cosmic expansion constitute the main basis for arguments to support or refute a possible apparent acceleration due to uneven dynamics in the universe as described by inhomogeneous cosmological models. We present in this Letter a separate argument based on results from the study of the growth rate of large-scale structure in the universe as modeled by the Szekeres inhomogeneous cosmological models. We use the models in all generality with no assumptions of spherical or axial symmetries. We find that Szekeres inhomogeneous models that fit well the observed expansion history fail to explain the observed late-time suppression of the growth of structure unless a cosmological constant is added to the dynamics.
Gait analysis using gravitational acceleration measured by wearable sensors.
Takeda, Ryo; Tadano, Shigeru; Todoh, Masahiro; Morikawa, Manabu; Nakayasu, Minoru; Yoshinari, Satoshi
2009-02-09
A novel method for measuring human gait posture using wearable sensor units is proposed. The sensor units consist of a tri-axial acceleration sensor and three gyro sensors aligned on three axes. The acceleration and angular velocity during walking were measured with seven sensor units worn on the abdomen and the lower limb segments (both thighs, shanks and feet). The three-dimensional positions of each joint are calculated from each segment length and joint angle. Joint angle can be estimated mechanically from the gravitational acceleration along the anterior axis of the segment. However, the acceleration data during walking includes three major components; translational acceleration, gravitational acceleration and external noise. Therefore, an optimization analysis was represented to separate only the gravitational acceleration from the acceleration data. Because the cyclic patterns of acceleration data can be found during constant walking, a FFT analysis was applied to obtain some characteristic frequencies in it. A pattern of gravitational acceleration was assumed using some parts of these characteristic frequencies. Every joint position was calculated from the pattern under the condition of physiological motion range of each joint. An optimized pattern of the gravitational acceleration was selected as a solution of an inverse problem. Gaits of three healthy volunteers were measured by walking for 20s on a flat floor. As a result, the acceleration data of every segment was measured simultaneously. The characteristic three-dimensional walking could be shown by the expression using a stick figure model. In addition, the trajectories of the knee joint in the horizontal plane could be checked by visual imaging on a PC. Therefore, this method provides important quantitive information for gait diagnosis.
Lee, Silvia Wen-Yu; Chang, Hsin-Yi; Wu, Hsin-Kai
2017-01-01
The aim of this study was to examine the potential impact of the representational characteristics of models and students' educational levels on students' views of scientific models and modeling (VSMM). An online multimedia questionnaire was designed to address three major aspects of VSMM, namely the "nature of models," the "nature…
Avelino, Arturo; Nucamendi, Ulises, E-mail: avelino@ifm.umich.mx, E-mail: ulises@ifm.umich.mx [Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio C-3, Ciudad Universitaria, CP. 58040, Morelia, Michoacán (Mexico)
2010-08-01
We explore the viability of a bulk viscous matter-dominated Universe to explain the present accelerated expansion of the Universe. The model is composed by a pressureless fluid with bulk viscosity of the form ζ = ζ{sub 0}+ζ{sub 1}H where ζ{sub 0} and ζ{sub 1} are constants and H is the Hubble parameter. The pressureless fluid characterizes both the baryon and dark matter components. We study the behavior of the Universe according to this model analyzing the scale factor as well as some curvature scalars and the matter density. On the other hand, we compute the best estimated values of ζ{sub 0} and ζ{sub 1} using the type Ia Supernovae (SNe Ia) probe. We find that from all the possible scenarios for the Universe, the preferred one by the best estimated values of (ζ{sub 0},ζ{sub 1}) is that of an expanding Universe beginning with a Big-Bang, followed by a decelerated expansion at early times, and with a smooth transition in recent times to an accelerated expansion epoch that is going to continue forever. The predicted age of the Universe is a little smaller than the mean value of the observational constraint coming from the oldest globular clusters but it is still inside of the confidence interval of this constraint. A drawback of the model is the violation of the local second law of thermodynamics in redshifts z∼>1. However, when we assume ζ{sub 1} = 0, the simple model ζ = ζ{sub 0} evaluated at the best estimated value for ζ{sub 0} satisfies the local second law of thermodynamics, the age of the Universe is in perfect agreement with the constraint of globular clusters, and it also has a Big-Bang, followed by a decelerated expansion with the smooth transition to an accelerated expansion epoch in late times, that is going to continue forever.
A MIXED LUBRICATION MODEL MODIFIED BY SURFACES' FRACTAL CHARACTERISTICS
孟凡明; 张有云
2003-01-01
Fractal characteristics are introduced into solving lubrication problems. Based on the analysis of the relationship between roughness and engineering surfaces' fractal characteristics and by introducing fractal parameters into the mixed lubrication equation, the relationship between flow factors and fractal dimensions is analyzed. The results show that the pressure flow factors' values increase, while the shear flow factor decreases, with the increasing length to width ratio of a representative asperity γ at the same fractal dimension. It can be also found that these factors experience more irregular and significant variations and show the higher resolution and the local optimal and the worst fractal dimensions, by a fractal dimension D, compared with the oil film thickness to roughness ratio h/Rq. As an example of application of the model to solve the lubrication of the piston skirt in an engine, the frictional force and the load capacity of the oil film in a cylinder were analyzed. The results reveal that the oil film frictional force and the load capacity fluctuate with increasing fractal dimension, showing big values at the small D and smaller ones and slightly variable in the range of bigger one, at the same crank angle.
The Model Characteristics of Physical Fitness in CrossFit
Vasilii V. Volkov
2014-06-01
Full Text Available The aim of the study is to work out the model characteristics of the physical fitness of CrossFit athletes based on laboratory functional testing (n=10. The analysis of the body composition was conducted using the dual-energy absorptiometry method. The morpho-functional characteristics of the heart were explored using a high-resolution ultrasound scanner. Oxygen consumption at the aerobic-anaerobic threshold and maximum oxygen consumption were determined in a step test on arm and leg cycle ergometers using a gas-analyzer. The level of the physical fitness of leg muscles in the males and females who took part in the study was satisfactory. However, it was considerably higher than the norm for untrained people. The level of the physical fitness of arm muscles was higher than the average and matched the Master of Sport of International Class standards. The productivity of the cardio-vascular system was much higher than in healthy males and females who do not work out and comparable to the standards for advanced soccer players.
Dynamic characteristics and mechatronics model for maglev blood pump
Sun, Kun; Chen, Chen
2017-01-01
Magnetic bearing system(MBs) has been developed in the new-generation blood pump due to its low power consumption, low blood trauma and high durability. However, MBs for a blood pump were almost influenced by a series of factors such as hemodynamics, rotation speeds and actuator response in working fluids, compared with those applied in other industrial fields. In this study, the dynamic characteristics of MBs in fluid environments, including the influence of the pumping fluid and rotation of the impeller on the radial dynamic model were investigated by measuring the frequency response to sinusoidal excitation upon coils, and the response of radial displacement during a raise in the speed. The excitation tests were conducted under conditions in which the blood pump was levitated in air and water and with or without rotation. The experimental and simulated results indicate that rotations of the impeller affected the characteristics of MBs in water apparently, and the vibration in water was decreased, compared with that in air due to the hydraulic force. During the start-up and rotation, the actuator failed to operate fully and timely, and the voltage supplied can be chosen under the consideration of the rotor displacement and consumption.
Modeling the gamma-ray emission in the Galactic Center with a fading cosmic-ray accelerator
Liu, Ruo-Yu; Prosekin, Anton; Chang, Xiao-Chuan
2016-01-01
Recent HESS observations of the ~200 pc scale diffuse gamma-ray emission from the central molecular zone (CMZ) suggest the presence of a PeV cosmic-ray accelerator (PeVatron) located in the inner 10 pc region of the Galactic Center. Interestingly, the gamma-ray spectrum of the point-like source (HESS J1745-290) in the Galactic Center shows a cutoff at ~10 TeV, implying a cutoff around 100 TeV in the cosmic-ray proton spectrum. Here we propose that the gamma-ray emission from the inner and the outer regions may be explained self-consistently by run-away protons from a single, yet fading accelerator. In this model, gamma rays from the CMZ region are produced by protons injected in the past, while gamma rays from the inner region are produced by protons injected more recently. We suggest that the blast wave formed in a tidal disruption event (TDE) caused by the supermassive black hole (Sgr A*) could serve as such a fading accelerator. With typical parameters of the TDE blast wave, gamma-ray spectra of both the C...
Burlon, A.A.; Girola, S. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina); Valda, A.A., E-mail: valda@tandar.cnea.gov.ar [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina); Minsky, D.M.; Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina)] [CONICET, Buenos Aires (Argentina); Sanchez, G. [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina)
2011-12-15
This work reports on the characterisation of a neutron beam shaping assembly (BSA) prototype and on the preliminary modelling of a treatment room for BNCT within the framework of a research programme for the development and construction of an accelerator-based BNCT irradiation facility in Buenos Aires, Argentina. The BSA prototype constructed has been characterised by means of MCNP simulations as well as a set of experimental measurements performed at the Tandar accelerator at the National Atomic Energy Commission of Argentina. - Highlights: Black-Right-Pointing-Pointer Characterisation of a neutron beam shaping assembly for accelerator-based BNCT. Black-Right-Pointing-Pointer Measurements: total and epi-cadmium neutron fluxes and beam homogeneity. Black-Right-Pointing-Pointer Calculations: Monte Carlo simulations with the MCNP code. Black-Right-Pointing-Pointer Measured and calculated figure-of-merit parameters in agreement with those of IAEA. Black-Right-Pointing-Pointer Initial MCNP dose calculations for a treatment room to define future design actions.
GPU加速三维特征线方法的研究%Study on Acceleration of Three-Dimensional Method of Characteristics by GPU
张知竹; 李庆; 王侃
2013-01-01
三维特征线方法可以精确求解任意几何堆芯的稳态多群中子输运方程,但同时也具有收敛慢、计算时间长的不足,需要研究相应的加速手段.图形处理器(GPU)计算由于具有速度快,能耗低的优点,被认为是未来高性能计算发展的方向之一.研究GPU计算加速三维特征线方法,并将其应用到三维特征线程序TCM中.借助统一计算设备架构(CUDA)的GPU计算,中央处理器(CPU)负责内存分配、有效增殖系数keff和源分布计算等逻辑性强或归约计算的处理,GPU执行特征线射线扫描细网求解细网通量.计算结果表明,经改写后的程序具有良好的加速效果.%The three-dimensional method of characteristics (MOC) can solve neutron transport equation for arbitrary geometry accurately.However,the MOC has some drawbacks:the convergence speed is slow and very time consuming.As a result,the research of acceleration of MOC is carried out.Compared with the CPU computing,the GPU computing,which is one of the most promising high performance computing,can achieve higher computing speed but with lower cost.And the development of general computing on GPU can be simplified with CUDA.To reduce the computing time and increase the computing efficiency,the study of three-dimensional MOC is performed and applied to the three-dimensional MOC code TCM.The computing results confirm the excellent acceleration of the code running on GPU.
Modeling the characteristics of wheel/rail rolling noise
Lui, Wai Keung; Li, Kai Ming; Frommer, Glenn H.
2005-04-01
To study the sound radiation characteristics of a passing train, four sets of noise measurements for different train operational conditions have been conducted at three different sites, including ballast tracks at grade and railway on a concrete viaduct. The time histories computed by the horizontal radiation models were compared with the measured noise profiles. The measured sound exposure levels are used to deduce the vertical directivity pattern for different railway systems. It is found that the vertical directivity of different railway systems shows a rather similar pattern. The vertical directivity of train noise is shown to increase up to about 30× before reducing to a minimum at 90×. A multipole expansion model is proposed to account for the vertical radiation directivity of the train noise. An empirical formula, which has been derived, compares well with the experimental data. The empirical model is found to be applicable to different train/rail systems at train speeds ranging up to 120 km/h in this study. [Work supported by MTR Corporation Ltd., Innovation Technology Commission of the HKSAR Government and The Hong Kong Polytechnic University.
Characteristics of the chiral phase transition in nonlocal quark models
Dumm, D G
2004-01-01
The characteristics of the chiral phase transition are analyzed within the framework of chiral quark models with nonlocal interactions in the mean field approximation (MFA). In the chiral limit, we show that there is a region of low values of the chemical potential in which the transition is a second order one. In that region, it is possible to perform a Landau expansion and determine the critical exponents which, as expected, turn out to be the MFA ones. Our analysis also allows to obtain semi-analytical expressions for the transition curve and the location of the tricritical point. For the case of finite current quark masses, we study the behavior of various thermodynamical and chiral response functions across the phase transition.
Accelerating Value Creation with Accelerators
Jonsson, Eythor Ivar
2015-01-01
accelerator programs. Microsoft runs accelerators in seven different countries. Accelerators have grown out of the infancy stage and are now an accepted approach to develop new ventures based on cutting-edge technology like the internet of things, mobile technology, big data and virtual reality. It is also...... with the traditional audit and legal universes and industries are examples of emerging potentials both from a research and business point of view to exploit and explore further. The accelerator approach may therefore be an Idea Watch to consider, no matter which industry you are in, because in essence accelerators...
Accelerating Value Creation with Accelerators
Jonsson, Eythor Ivar
2015-01-01
Accelerators can help to accelerate value creation. Accelerators are short-term programs that have the objective of creating innovative and fast growing ventures. They have gained attraction as larger corporations like Microsoft, Barclays bank and Nordea bank have initiated and sponsored accelera......Accelerators can help to accelerate value creation. Accelerators are short-term programs that have the objective of creating innovative and fast growing ventures. They have gained attraction as larger corporations like Microsoft, Barclays bank and Nordea bank have initiated and sponsored...... an approach to facilitate implementation and realization of business ideas and is a lucrative approach to transform research into ventures and to revitalize regions and industries in transition. Investors have noticed that the accelerator approach is a way to increase the possibility of success by funnelling...
Lee, Silvia Wen-Yu; Chang, Hsin-Yi; Wu, Hsin-Kai
2017-04-01
The aim of this study was to examine the potential impact of the representational characteristics of models and students' educational levels on students' views of scientific models and modeling (VSMM). An online multimedia questionnaire was designed to address three major aspects of VSMM, namely the nature of models, the nature of modeling, and the purpose of models. The three scales of representational characteristics included modality, dimensionality, and dynamics. A total of 102 eighth graders and 87 eleventh graders were surveyed. Both quantitative data and written responses were analyzed. The influence of the representational characteristics seemed to be more salient on the nature of models and the purpose of models. Some interactions between the educational levels and the representational characteristics showed that the high school students were more likely to recognize textual representations and pictorial representations as models, while also being more likely to appreciate the differences between 2D and 3D models. However, some other differences between educational levels did not necessarily suggest that the high school students attained more sophisticated VSMM. For instance, in considering what information should be included in a model, students' attention to particular affordances of the representation can lead to a more naive view of modeling. Implications for developing future questionnaires and for teaching modeling are suggested in this study.
Mehrling, T.J., E-mail: timon.mehrling@desy.de [Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg (Germany); Robson, R.E. [Centre for Quantum Dynamics, School of Natural Sciences, Griffith University, Brisbane (Australia); Erbe, J-H.; Osterhoff, J. [Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg (Germany)
2016-09-01
This paper introduces a semi-analytic numerical approach (SANA) for the rapid computation of the transverse emittance of beams with finite energy spread in plasma wakefield accelerators in the blowout regime. The SANA method is used to model the beam emittance evolution when injected into and extracted from realistic plasma profiles. Results are compared to particle-in-cell simulations, establishing the accuracy and efficiency of the procedure. In addition, it is demonstrated that the tapering of vacuum-to-plasma and plasma-to-vacuum transitions is a viable method for the mitigation of emittance growth of beams during their injection and extraction from and into plasma cells.
A model of the TeV flare of Cygnus X-1: electron acceleration and extended pair cascades
Zdziarski, A A; Bednarek, W
2008-01-01
We consider theoretical models of emission of TeV photons by Cyg X-1 during a flare discovered by the MAGIC detector. We study acceleration of electrons to energies sufficient for TeV emission, and find the emission site is allowed to be close to the black hole. We then consider pair absorption in the photon field of the central X-ray source and a surrounding accretion disc, and find its optical depth is 3 TeV, in which photons travel far away from the star, initiating a spatially extended pair cascade. This qualitatively explains the observed TeV spectrum, though still not its exact shape.
High-performance modeling of plasma-based acceleration and laser-plasma interactions
Vay, Jean-Luc; Blaclard, Guillaume; Godfrey, Brendan; Kirchen, Manuel; Lee, Patrick; Lehe, Remi; Lobet, Mathieu; Vincenti, Henri
2016-10-01
Large-scale numerical simulations are essential to the design of plasma-based accelerators and laser-plasma interations for ultra-high intensity (UHI) physics. The electromagnetic Particle-In-Cell (PIC) approach is the method of choice for self-consistent simulations, as it is based on first principles, and captures all kinetic effects, and also scale favorably to many cores on supercomputers. The standard PIC algorithm relies on second-order finite-difference discretization of the Maxwell and Newton-Lorentz equations. We present here novel formulations, based on very high-order pseudo-spectral Maxwell solvers, which enable near-total elimination of the numerical Cherenkov instability and increased accuracy over the standard PIC method for standard laboratory frame and Lorentz boosted frame simulations. We also present the latest implementations in the PIC modules Warp-PICSAR and FBPIC on the Intel Xeon Phi and GPU architectures. Examples of applications will be given on the simulation of laser-plasma accelerators and high-harmonic generation with plasma mirrors. Work supported by US-DOE Contracts DE-AC02-05CH11231 and by the European Commission through the Marie Slowdoska-Curie fellowship PICSSAR Grant Number 624543. Used resources of NERSC.
A Framework for 3D Model-Based Visual Tracking Using a GPU-Accelerated Particle Filter.
Brown, J A; Capson, D W
2012-01-01
A novel framework for acceleration of particle filtering approaches to 3D model-based, markerless visual tracking in monocular video is described. Specifically, we present a methodology for partitioning and mapping the computationally expensive weight-update stage of a particle filter to a graphics processing unit (GPU) to achieve particle- and pixel-level parallelism. Nvidia CUDA and Direct3D are employed to harness the massively parallel computational power of modern GPUs for simulation (3D model rendering) and evaluation (segmentation, feature extraction, and weight calculation) of hundreds of particles at high speeds. The proposed framework addresses the computational intensity that is intrinsic to all particle filter approaches, including those that have been modified to minimize the number of particles required for a particular task. Performance and tracking quality results for rigid object and articulated hand tracking experiments demonstrate markerless, model-based visual tracking on consumer-grade graphics hardware with pixel-level accuracy up to 95 percent at 60+ frames per second. The framework accelerates particle evaluation up to 49 times over a comparable CPU-only implementation, providing an increased particle count while maintaining real-time frame rates.
Temple, Blake; Smoller, Joel
2009-08-25
We derive a system of three coupled equations that implicitly defines a continuous one-parameter family of expanding wave solutions of the Einstein equations, such that the Friedmann universe associated with the pure radiation phase of the Standard Model of Cosmology is embedded as a single point in this family. By approximating solutions near the center to leading order in the Hubble length, the family reduces to an explicit one-parameter family of expanding spacetimes, given in closed form, that represents a perturbation of the Standard Model. By introducing a comoving coordinate system, we calculate the correction to the Hubble constant as well as the exact leading order quadratic correction to the redshift vs. luminosity relation for an observer at the center. The correction to redshift vs. luminosity entails an adjustable free parameter that introduces an anomalous acceleration. We conclude (by continuity) that corrections to the redshift vs. luminosity relation observed after the radiation phase of the Big Bang can be accounted for, at the leading order quadratic level, by adjustment of this free parameter. The next order correction is then a prediction. Since nonlinearities alone could actuate dissipation and decay in the conservation laws associated with the highly nonlinear radiation phase and since noninteracting expanding waves represent possible time-asymptotic wave patterns that could result, we propose to further investigate the possibility that these corrections to the Standard Model might be the source of the anomalous acceleration of the galaxies, an explanation not requiring the cosmological constant or dark energy.
Evaluating models for predicting hydraulic characteristics of layered soils
Mavimbela, S. S. W.; van Rensburg, L. D.
2012-01-01
Soil water characteristic curve (SWCC) and unsaturated hydraulic conductivity (K-coefficient) are critical hydraulic properties governing soil water activity on layered soils. Sustainable soil water conservation would not be possible without accurate knowledge of these hydraulic properties. Infield rainwater harvesting (IRWH) is one conservation technique adopted to improve the soil water regime of a number of clay soils found in the semi arid areas of Free State province of South Africa. Given that SWCC is much easier to measure, most soil water studies rely on SWCC information to predict in-situ K-coefficients. This work validated this practice on the Tukulu, Sepane and Swartland layered soil profiles. The measured SWCC was first described using Brooks and Corey (1964), van Genuchten (1980) and Kasugi (1996) parametric models. The conductivity functions of these models were then required to fit in-situ based K-coefficients derived from instantaneous profile method (IPM). The same K-coefficient was also fitted by HYDRUS 1-D using optimised SWCC parameters. Although all parametric models fitted the measured SWCC fairly well their corresponding conductivity functions could not do the same when fitting the in-situ based K-coefficients. Overestimates of more than 2 orders of magnitude especially at low soil water content (SWC) were observed. This phenomenon was pronounced among the upper horizons that overlaid a clayey horizon. However, optimized α and n parameters using HYDRUS 1-D showed remarkable agreement between fitted and in-situ K-coefficient with root sum of squares error (RMSE) recording values not exceeding unity. During this exercise the Brooks and Corey was replaced by modified van Genuchten model (Vogel and Cislerova, 1988) since it failed to produce unique inverse solutions. The models performance appeared to be soil specific with van Genuchten-Mualem (1980) performing fairly well on the Orthic and neucutanic horizons while its modified form fitted very
Evaluating models for predicting hydraulic characteristics of layered soils
S. S. W. Mavimbela
2012-01-01
Full Text Available Soil water characteristic curve (SWCC and unsaturated hydraulic conductivity (K-coefficient are critical hydraulic properties governing soil water activity on layered soils. Sustainable soil water conservation would not be possible without accurate knowledge of these hydraulic properties. Infield rainwater harvesting (IRWH is one conservation technique adopted to improve the soil water regime of a number of clay soils found in the semi arid areas of Free State province of South Africa. Given that SWCC is much easier to measure, most soil water studies rely on SWCC information to predict in-situ K-coefficients. This work validated this practice on the Tukulu, Sepane and Swartland layered soil profiles. The measured SWCC was first described using Brooks and Corey (1964, van Genuchten (1980 and Kasugi (1996 parametric models. The conductivity functions of these models were then required to fit in-situ based K-coefficients derived from instantaneous profile method (IPM. The same K-coefficient was also fitted by HYDRUS 1-D using optimised SWCC parameters. Although all parametric models fitted the measured SWCC fairly well their corresponding conductivity functions could not do the same when fitting the in-situ based K-coefficients. Overestimates of more than 2 orders of magnitude especially at low soil water content (SWC were observed. This phenomenon was pronounced among the upper horizons that overlaid a clayey horizon. However, optimized α and n parameters using HYDRUS 1-D showed remarkable agreement between fitted and in-situ K-coefficient with root sum of squares error (RMSE recording values not exceeding unity. During this exercise the Brooks and Corey was replaced by modified van Genuchten model (Vogel and Cislerova, 1988 since it failed to produce unique inverse solutions. The models performance appeared to be soil specific with van Genuchten-Mualem (1980 performing fairly well on the Orthic
Prafulla Kumar SWAIN
2016-04-01
Full Text Available Objective: The present paper demonstrates the applications of Accelerated Failure Time (AFT model with gamma and inverse Gaussian frailty distributions to estimate the effect of prognostic factors on the survival of HIV/AIDS patients undergoing Antiretroviral Therapy (ART in Delhi, India. Material and Methods: The results of both these models have been compared to without frailty model. Akaike Information Criterion (AIC and Bayesian Information criterion (BIC have been used to select best model for HIV/AIDS data. Results: The prognostic factors sex, mode of transmission, baseline hemoglobin and weight are found to be statistically significant (P-value <0.05 for HIV/AIDS patients on ART. Gamma shared frailty model with lognormal as baseline distribution is found to be the best model for HIV/AIDS patients. The model also reflected there is strong evidence of high degree of heterogeneity in the HIV/AIDS patients. Conclusion: Therefore shared frailty model is an appropriate approach for analyzing the HIV/AIDS data than without frailty model.
Hrbacek, Jan; Lang, Stephanie; Klöck, Stephan
2011-07-15
To investigate dosimetric characteristics of a new linear accelerator designed to deliver flattened, as well as flattening filter-free (FFF), beams. To evaluate the accuracy of beam modeling under physical conditions using an anisotropic analytical algorithm. Dosimetric data including depth dose curves, profiles, surface dose, penumbra, out-of-field dose, output, total and scatter factors were examined for four beams (X6, X6FFF, X10, and X10FFF) of Varian's TrueBeam machine. Beams modeled by anisotropic analytical algorithm were compared with measured dataset. FFF beams have lower mean energy (tissue-phantom ratio at the depths of 20 and 10 cm (TPR 20/10): X6, 0.667; X6FFF, 0.631; X10, 0.738; X10FFF, 0.692); maximum dose is located closer to the surface; and surface dose increases by 10%. FFF profiles have sharper but faster diverging penumbra. For small fields and shallow depths, dose outside a field is lower for FFF beams; however, the advantage fades with increasing phantom scatter. Output increases 2.26 times for X6FFF and 4.03 times for X10FFF and is less variable with field size; collimator exchange effect is reduced. A good agreement between modeled and measured data is observed. Criteria of 2% depth-dose and 2-mm distance-to-agreement are always met. Reference dosimetric characteristics of TrueBeam photon bundles were obtained, and successful modeling of the beams was achieved. Copyright © 2011 Elsevier Inc. All rights reserved.
Synchronized ion acceleration by ultraintense slow light
Brantov, A V; Kovalev, V F; Bychenkov, V Yu
2015-01-01
An effective scheme of synchronized laser-triggered ion acceleration and the corresponding theoretical model are proposed for a slow light pulse of relativistic intensity, which penetrates into a near-critical-density plasma, strongly slows, and then increases its group velocity during propagation within a target. The 3D PIC simulations confirm this concept for proton acceleration by a femtosecond petawatt-class laser pulse experiencing relativistic self-focusing, quantify the characteristics of the generated protons, and demonstrate a significant increase of their energy compared with the proton energy generated from optimized ultrathin solid dense foils.
Sayyar-Rodsari, Bijan; Schweiger, Carl; Hartman, Eric
2007-10-07
The difficult problems being tackled in the accelerator community are those that are nonlinear, substantially unmodeled, and vary over time. Such problems are ideal candidates for model-based optimization and control if representative models of the problem can be developed that capture the necessary mathematical relations and remain valid throughout the operation region of the system, and through variations in system dynamics. The goal of this proposal is to develop the methodology and the algorithms for building high-fidelity mathematical representations of complex nonlinear systems via constrained training of combined first-principles and neural network models.
Accelerated simulation of stochastic particle removal processes in particle-resolved aerosol models
Curtis, J. H.; Michelotti, M. D.; Riemer, N.; Heath, M. T.; West, M.
2016-10-01
Stochastic particle-resolved methods have proven useful for simulating multi-dimensional systems such as composition-resolved aerosol size distributions. While particle-resolved methods have substantial benefits for highly detailed simulations, these techniques suffer from high computational cost, motivating efforts to improve their algorithmic efficiency. Here we formulate an algorithm for accelerating particle removal processes by aggregating particles of similar size into bins. We present the Binned Algorithm for particle removal processes and analyze its performance with application to the atmospherically relevant process of aerosol dry deposition. We show that the Binned Algorithm can dramatically improve the efficiency of particle removals, particularly for low removal rates, and that computational cost is reduced without introducing additional error. In simulations of aerosol particle removal by dry deposition in atmospherically relevant conditions, we demonstrate about 50-times increase in algorithm efficiency.
Accelerated simulation of stochastic particle removal processes in particle-resolved aerosol models
Curtis, J.H. [Department of Atmospheric Sciences, University of Illinois at Urbana–Champaign, 105 S. Gregory St., Urbana, IL 61801 (United States); Michelotti, M.D. [Department of Computer Science, University of Illinois at Urbana–Champaign, 201 North Goodwin Avenue, Urbana, IL 61801 (United States); Riemer, N. [Department of Atmospheric Sciences, University of Illinois at Urbana–Champaign, 105 S. Gregory St., Urbana, IL 61801 (United States); Heath, M.T. [Department of Computer Science, University of Illinois at Urbana–Champaign, 201 North Goodwin Avenue, Urbana, IL 61801 (United States); West, M., E-mail: mwest@illinois.edu [Department of Mechanical Science and Engineering, University of Illinois at Urbana–Champaign, 1206 W. Green St., Urbana, IL 61801 (United States)
2016-10-01
Stochastic particle-resolved methods have proven useful for simulating multi-dimensional systems such as composition-resolved aerosol size distributions. While particle-resolved methods have substantial benefits for highly detailed simulations, these techniques suffer from high computational cost, motivating efforts to improve their algorithmic efficiency. Here we formulate an algorithm for accelerating particle removal processes by aggregating particles of similar size into bins. We present the Binned Algorithm for particle removal processes and analyze its performance with application to the atmospherically relevant process of aerosol dry deposition. We show that the Binned Algorithm can dramatically improve the efficiency of particle removals, particularly for low removal rates, and that computational cost is reduced without introducing additional error. In simulations of aerosol particle removal by dry deposition in atmospherically relevant conditions, we demonstrate about 50-times increase in algorithm efficiency.
A modeling GUI for accelerator physics of the storage ring at SSRF
CHEN Guangling; TIAN Shunqiang; LIU Guimin; JIANG Bocheng
2009-01-01
In this paper, we report a MATLAB-based GUI tool, bodgui, which integrates functions of lattice editor,linear match, and nonlinear optimization, and visualized tracking functions for beam optics design. A user can switch his/ber design procedures one to another. Flexibilities are provided for adjusting or optimizing the lattice settings in commissioning or operation of the accelerators. The algorithm of the linear match and nonlinear optimization, and the GUI windows including the main functions and running status, are presented. The SSRF storage ring was employed as a test lattice. Several optics modes designed and optimized by the GUI tools were used for commissioning the storage ring. Functions of bodgui tool are machine-independent, and it can be well applied to modern light sources being built in other parts of the world.
Celaya, Jose R.; Kulkarni, Chetan S.; Biswas, Gautam; Goebel, Kai
2012-01-01
A remaining useful life prediction methodology for electrolytic capacitors is presented. This methodology is based on the Kalman filter framework and an empirical degradation model. Electrolytic capacitors are used in several applications ranging from power supplies on critical avionics equipment to power drivers for electro-mechanical actuators. These devices are known for their comparatively low reliability and given their criticality in electronics subsystems they are a good candidate for component level prognostics and health management. Prognostics provides a way to assess remaining useful life of a capacitor based on its current state of health and its anticipated future usage and operational conditions. We present here also, experimental results of an accelerated aging test under electrical stresses. The data obtained in this test form the basis for a remaining life prediction algorithm where a model of the degradation process is suggested. This preliminary remaining life prediction algorithm serves as a demonstration of how prognostics methodologies could be used for electrolytic capacitors. In addition, the use degradation progression data from accelerated aging, provides an avenue for validation of applications of the Kalman filter based prognostics methods typically used for remaining useful life predictions in other applications.
Kanamaru, Takuya; Kamimura, Naomi; Yokota, Takashi; Iuchi, Katsuya; Nishimaki, Kiyomi; Takami, Shinya; Akashiba, Hiroki; Shitaka, Yoshitsugu; Katsura, Ken-Ichiro; Kimura, Kazumi; Ohta, Shigeo
2015-02-05
Oxidative stress is known to play a prominent role in the onset and early stage progression of Alzheimer's disease (AD). For example, protein oxidation and lipid peroxidation levels are increased in patients with mild cognitive impairment. Here, we created a double-transgenic mouse model of AD to explore the pathological and behavioral effects of oxidative stress. Double transgenic (APP/DAL) mice were constructed by crossing Tg2576 (APP) mice, which express a mutant form of human amyloid precursor protein (APP), with DAL mice expressing a dominant-negative mutant of mitochondrial aldehyde dehydrogenase 2 (ALDH2), in which oxidative stress is enhanced. Y-maze and object recognition tests were performed at 3 and 6 months of age to evaluate learning and memory. The accumulation of amyloid plaques, deposition of phosphorylated-tau protein, and number of astrocytes in the brain were assessed histopathologically at 3, 6, 9, and 12-15 months of age. The life span of APP/DAL mice was significantly shorter than that of APP or DAL mice. In addition, they showed accelerated amyloid deposition, tau phosphorylation, and gliosis. Furthermore, these mice showed impaired performance on Y-maze and object recognition tests at 3 months of age. These data suggest that oxidative stress accelerates cognitive dysfunction and pathological insults in the brain. APP/DAL mice could be a useful model for exploring new approaches to AD treatment. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
一种改进的岩石黏弹塑性加速蠕变力学模型%An improved accelerated creep mechanical model of viscoelasto-plastic rock
曹平; 刘业科; 蒲成志; 陈锐; 汪亦显
2011-01-01
为了全面描述岩石蠕变全过程,克服线性牛顿体不能准确描述加速蠕变的不足,在引入非线性蠕变体模型基础上,结合流变力学模型理论,定义应力与试件长期强度的比值为加速蠕变速率幂级数,n,模型发生加速蠕变时的总蠕变量为蠕变特征长度εc,进而得到一种改进的能够描述岩石黏弹塑性加速蠕变的力学模型.结合东乡铜矿砂质页岩单轴压缩下分级增量循环加卸载蠕变试验,对模型参数的辨识进行解释,并将该模型的蠕变拟合曲线与实验的蠕变曲线进行对比.研究结果表明:该模型能很好地描述了岩石的加速蠕变特性.%In order to depict the process of rock creep comprehensively, and overcome the deficiency of the linear Newton fluid which can not describe accelerated creep accurately, based on the mature rheological model, the nonlinear creep body model was introduced.In this model, the total creep strain before accelerated creep stage was defined as the characteristic length of creep, and the ratio of stress level and long-term strength of rock specimens was defined as accelerated creep rate.The improved rheological mechanics model was established that can describe the viscoelastic-plastic characteristics of accelerated creep.Combined with the uniaxial compression creep test under multi-step incremental cycling loading and unloading on the sandy shale from Dongxiang Copper Mine, the parameter identification of the mechanical model was explained, the experimental creep curve was compared with the creep fitted curve obtained by the model.The results show that the accelerate creep properties of rocks can be described effectively by this improved creep model.
Sayyar-Rodsari, Bijan; Schweiger, Carl; /SLAC /Pavilion Technologies, Inc., Austin, TX
2010-08-25
parameters of the beam lifetime model) are physically meaningful. (3) Numerical Efficiency of the Training - We investigated the numerical efficiency of the SVM training. More specifically, for the primal formulation of the training, we have developed a problem formulation that avoids the linear increase in the number of the constraints as a function of the number of data points. (4) Flexibility of Software Architecture - The software framework for the training of the support vector machines was designed to enable experimentation with different solvers. We experimented with two commonly used nonlinear solvers for our simulations. The primary application of interest for this project has been the sustained optimal operation of particle accelerators at the Stanford Linear Accelerator Center (SLAC). Particle storage rings are used for a variety of applications ranging from 'colliding beam' systems for high-energy physics research to highly collimated x-ray generators for synchrotron radiation science. Linear accelerators are also used for collider research such as International Linear Collider (ILC), as well as for free electron lasers, such as the Linear Coherent Light Source (LCLS) at SLAC. One common theme in the operation of storage rings and linear accelerators is the need to precisely control the particle beams over long periods of time with minimum beam loss and stable, yet challenging, beam parameters. We strongly believe that beyond applications in particle accelerators, the high fidelity and cost benefits of a combined model-based fault estimation/correction system will attract customers from a wide variety of commercial and scientific industries. Even though the acquisition of Pavilion Technologies, Inc. by Rockwell Automation Inc. in 2007 has altered the small business status of the Pavilion and it no longer qualifies for a Phase II funding, our findings in the course of the Phase I research have convinced us that further research will render a workable
Sayyar-Rodsari, Bijan; Schweiger, Carl; /SLAC /Pavilion Technologies, Inc., Austin, TX
2010-08-25
parameters of the beam lifetime model) are physically meaningful. (3) Numerical Efficiency of the Training - We investigated the numerical efficiency of the SVM training. More specifically, for the primal formulation of the training, we have developed a problem formulation that avoids the linear increase in the number of the constraints as a function of the number of data points. (4) Flexibility of Software Architecture - The software framework for the training of the support vector machines was designed to enable experimentation with different solvers. We experimented with two commonly used nonlinear solvers for our simulations. The primary application of interest for this project has been the sustained optimal operation of particle accelerators at the Stanford Linear Accelerator Center (SLAC). Particle storage rings are used for a variety of applications ranging from 'colliding beam' systems for high-energy physics research to highly collimated x-ray generators for synchrotron radiation science. Linear accelerators are also used for collider research such as International Linear Collider (ILC), as well as for free electron lasers, such as the Linear Coherent Light Source (LCLS) at SLAC. One common theme in the operation of storage rings and linear accelerators is the need to precisely control the particle beams over long periods of time with minimum beam loss and stable, yet challenging, beam parameters. We strongly believe that beyond applications in particle accelerators, the high fidelity and cost benefits of a combined model-based fault estimation/correction system will attract customers from a wide variety of commercial and scientific industries. Even though the acquisition of Pavilion Technologies, Inc. by Rockwell Automation Inc. in 2007 has altered the small business status of the Pavilion and it no longer qualifies for a Phase II funding, our findings in the course of the Phase I research have convinced us that further research will render a workable
Olive mill wastewater characteristics: modelling and statistical analysis
Martins-Dias, Susete
2004-09-01
Full Text Available A synthesis of the work carried out on Olive Mill Wastewater (OMW characterisation is given, covering articles published over the last 50 years. Data on OMW characterisation found in the literature are summarised and correlations between them and with phenolic compounds content are sought. This permits the characteristics of an OMW to be estimated from one simple measurement: the phenolic compounds concentration. A model based on OMW characterisations accounting 6 countries was developed along with a model for Portuguese OMW. The statistical analysis of the correlations obtained indicates that Chemical Oxygen Demand of a given OMW is a second-degree polynomial function of its phenolic compounds concentration. Tests to evaluate the regressions significance were carried out, based on multivariable ANOVA analysis, on visual standardised residuals distribution and their means for confidence levels of 95 and 99 %, validating clearly these models. This modelling work will help in the future planning, operation and monitoring of an OMW treatment plant.Presentamos una síntesis de los trabajos realizados en los últimos 50 años relacionados con la caracterización del alpechín. Realizamos una recopilación de los datos publicados, buscando correlaciones entre los datos relativos al alpechín y los compuestos fenólicos. Esto permite la determinación de las características del alpechín a partir de una sola medida: La concentración de compuestos fenólicos. Proponemos dos modelos, uno basado en datos relativos a seis países y un segundo aplicado únicamente a Portugal. El análisis estadístico de las correlaciones obtenidas indica que la demanda química de oxígeno de un determinado alpechín es una función polinómica de segundo grado de su concentración de compuestos fenólicos. Se comprobó la significancia de esta correlación mediante la aplicación del análisis multivariable ANOVA, y además se evaluó la distribución de residuos y sus
BERG,J.S.; GARREN,A.A.; JOHNSTONE,C.
2000-04-07
This paper compares various types of recirculating accelerators, outlining the advantages and disadvantages of various approaches. The accelerators are characterized according to the types of arcs they use: whether there is a single arc for the entire recirculator or there are multiple arcs, and whether the arc(s) are isochronous or non-isochronous.
2002-01-01
The prototype module of LIBO, a linear accelerator project designed for cancer therapy, has passed its first proton-beam acceleration test. In parallel a new version - LIBO-30 - is being developed, which promises to open up even more interesting avenues.
Damir Hamamdzic
2013-01-01
Full Text Available Animal models of atherosclerosis have proven to be an invaluable asset in understanding the pathogenesis of the disease. However, large animal models may be needed in order to assess novel therapeutic approaches to the treatment of atherosclerosis. Porcine models of coronary and peripheral atherosclerosis offer several advantages over rodent models, including similar anatomical size to humans, as well as genetic expression and development of high-risk atherosclerotic lesions which are similar to humans. Here we review the four models of porcine atherosclerosis, including the diabetic/hypercholesterolemic model, Rapacz-familial hypercholesterolemia pig, the (PCSK9 gain-of-function mutant pig model, and the Ossabaw miniature pig model of metabolic syndrome. All four models reliably represent features of human vascular disease.
AUTHOR|(CDS)2266999
2017-01-01
CERN has been involved in the dissemination of scientific results since its early days and has continuously updated the distribution channels. Currently, Inspire hosts catalogues of articles, authors, institutions, conferences, jobs, experiments, journals and more. Successful orientation among this amount of data requires comprehensive linking between the content. Inspire has lacked a system for linking experiments and articles together based on which accelerator they were conducted at. The purpose of this project has been to create such a system. Records for 156 accelerators were created and all 2913 experiments on Inspire were given corresponding MARC tags. Records of 18404 accelerator physics related bibliographic entries were also tagged with corresponding accelerator tags. Finally, as a part of the endeavour to broaden CERN's presence on Wikipedia, existing Wikipedia articles of accelerators were updated with short descriptions and links to Inspire. In total, 86 Wikipedia articles were updated. This repo...
Ecker, Madeleine; Gerschler, Jochen B.; Vogel, Jan; Käbitz, Stefan; Hust, Friedrich; Dechent, Philipp; Sauer, Dirk Uwe
2012-10-01
Battery lifetime prognosis is a key requirement for successful market introduction of electric and hybrid vehicles. This work aims at the development of a lifetime prediction approach based on an aging model for lithium-ion batteries. A multivariable analysis of a detailed series of accelerated lifetime experiments representing typical operating conditions in hybrid electric vehicle is presented. The impact of temperature and state of charge on impedance rise and capacity loss is quantified. The investigations are based on a high-power NMC/graphite lithium-ion battery with good cycle lifetime. The resulting mathematical functions are physically motivated by the occurring aging effects and are used for the parameterization of a semi-empirical aging model. An impedance-based electric-thermal model is coupled to the aging model to simulate the dynamic interaction between aging of the battery and the thermal as well as electric behavior. Based on these models different drive cycles and management strategies can be analyzed with regard to their impact on lifetime. It is an important tool for vehicle designers and for the implementation of business models. A key contribution of the paper is the parameterization of the aging model by experimental data, while aging simulation in the literature usually lacks a robust empirical foundation.
Gutt, F.; Silva, P.; Guerrero, R.; Diaz, J.; Colmenares, J. [Instituto Venezolano de Investigaciones Cientificas (IVIC), Laboratorio Secundario de Calibracion Dosimetrica (LSCD), Apartado 21827, Caracas 1020 A (Venezuela)
1998-12-31
The objective of the present work is to find a physical mathematical model based on the reason of the dose percentages at 10 and 20 cm depth, at 100 cm DFS and a 10 x 10 cm{sup 2} field. It was utilized literature data of new manufactured accelerators and those are in use in hospitals, which allow to prove the model under different conditions. Our objective consists only to obtain a model that verifies the nominal potential for a linear accelerator, but without pretending that such a model to be used to calculate any one factor to determination of absorbed dose. (Author)
Computer Modelling and Simulation of Solar PV Array Characteristics
Gautam, Nalin Kumar
2003-02-01
The main objective of my PhD research work was to study the behaviour of inter-connected solar photovoltaic (PV) arrays. The approach involved the construction of mathematical models to investigate different types of research problems related to the energy yield, fault tolerance, efficiency and optimal sizing of inter-connected solar PV array systems. My research work can be divided into four different types of research problems: 1. Modeling of inter-connected solar PV array systems to investigate their electrical behavior, 2. Modeling of different inter-connected solar PV array networks to predict their expected operational lifetimes, 3. Modeling solar radiation estimation and its variability, and 4. Modeling of a coupled system to estimate the size of PV array and battery-bank in the stand-alone inter-connected solar PV system where the solar PV system depends on a system providing solar radiant energy. The successful application of mathematics to the above-m entioned problems entailed three phases: 1. The formulation of the problem in a mathematical form using numerical, optimization, probabilistic and statistical methods / techniques, 2. The translation of mathematical models using C++ to simulate them on a computer, and 3. The interpretation of the results to see how closely they correlated with the real data. Array is the most cost-intensive component of the solar PV system. Since the electrical performances as well as life properties of an array are highly sensitive to field conditions, different characteristics of the arrays, such as energy yield, operational lifetime, collector orientation, and optimal sizing were investigated in order to improve their efficiency, fault-tolerance and reliability. Three solar cell interconnection configurations in the array - series-parallel, total-cross-tied, and bridge-linked, were considered. The electrical characteristics of these configurations were investigated to find out one that is comparatively less susceptible to
Phromwong, P.; Lister, D., E-mail: c7r13@unb.ca [Univ. of New Brunswick, Dept. of Chemical Engineering, Fredericton, New Brunswick (Canada); Uchida, S. [Japan Atomic Energy Agency, Tokai-mura, Ibaraki (Japan)
2012-07-01
The effects of chromium content on flow-accelerated corrosion (FAC) of carbon steel have been predicted very well by including a passivating layer, which is a chromium-dependent diffusion barrier at the metal-oxide interface. By adjusting the properties of the chromium-dependent layer, described with a Passivation Parameter (PP), we can predict the FAC of carbon steel of different chromium contents in typical reactor feed-water environments (140{sup o}C and neutral or ammoniated chemistry). The model and an appropriate PP are also applied to the environment typical of carbon-steel feeders in the primary coolant of a CANDU reactor (310{sup o}C and lithiated chemistry). The model predicts FAC rate very well (with a deviation of 10% or less) in both situations. (author)
Zhang, Yi; Gabr, Refaat E.; Zhou, Jinyuan; Weiss, Robert G.; Bottomley, Paul A.
2013-12-01
Noninvasive magnetic resonance spectroscopy (MRS) with chemical shift imaging (CSI) provides valuable metabolic information for research and clinical studies, but is often limited by long scan times. Recently, spectroscopy with linear algebraic modeling (SLAM) was shown to provide compartment-averaged spectra resolved in one spatial dimension with many-fold reductions in scan-time. This was achieved using a small subset of the CSI phase-encoding steps from central image k-space that maximized the signal-to-noise ratio. Here, SLAM is extended to two- and three-dimensions (2D, 3D). In addition, SLAM is combined with sensitivity-encoded (SENSE) parallel imaging techniques, enabling the replacement of even more CSI phase-encoding steps to further accelerate scan-speed. A modified SLAM reconstruction algorithm is introduced that significantly reduces the effects of signal nonuniformity within compartments. Finally, main-field inhomogeneity corrections are provided, analogous to CSI. These methods are all tested on brain proton MRS data from a total of 24 patients with brain tumors, and in a human cardiac phosphorus 3D SLAM study at 3T. Acceleration factors of up to 120-fold versus CSI are demonstrated, including speed-up factors of 5-fold relative to already-accelerated SENSE CSI. Brain metabolites are quantified in SLAM and SENSE SLAM spectra and found to be indistinguishable from CSI measures from the same compartments. The modified reconstruction algorithm demonstrated immunity to maladjusted segmentation and errors from signal heterogeneity in brain data. In conclusion, SLAM demonstrates the potential to supplant CSI in studies requiring compartment-average spectra or large volume coverage, by dramatically reducing scan-time while providing essentially the same quantitative results.
Sklenicka, V.; Kucharova, K.; Svoboda, M.; Kroupa, A.; Kloc, L. [Academy of Sciences of the Czech Republic, Brno (Czech Republic). Inst. of Physics of Materials; Cmakal, J. [UJP PRAHA a.s., Praha-Zbraslav (Czech Republic)
2010-07-01
Creep behaviour and degradation of creep properties of creep resistant materials are phenomena of major practical relevance, often limiting the lives of components and structures designed to operate for long periods under stress at elevated and/or high temperatures. Since life expectancy is, in reality, based on the ability of the material to retain its high-temperature creep strength for the projected designed life, methods of creep properties assessment based on microstructural evolution in the material during creep rather than simple parametric extrapolation of short-term creep tests are necessary. In this paper we will try to further clarify the creep-strength degradation of selected advanced creep resistant steels. In order to accelerate some microstructural changes and thus to simulate degradation processes in long-term service, isothermal ageing at 650 C for 10 000 h was applied to P91 and P23 steels in their as-received states. The accelerated tensile creep tests were performed at temperature 600 C in argon atmosphere on all steels both in the as-received state and after long-term isothermal ageing, in an effort to obtain a more complete description of the role of microstructural stability in high temperature creep of these steels. Creep tests were followed by microstructural investigations by means of both transmission and scanning electron microscopy and by the thermodynamic calculations. The applicability of the accelerated creep tests was verified by the theoretical modelling of the phase equilibria at different temperatures. It is suggested that under restructed oxidation due to argon atmosphere microstructural instability is the main detrimental process in the long-term degradation of the creep rupture strength of these steels. (orig.)
The Accelerated Kepler Problem
Namouni, Fathi
2007-01-01
The accelerated Kepler problem is obtained by adding a constant acceleration to the classical two-body Kepler problem. This setting models the dynamics of a jet-sustaining accretion disk and its content of forming planets as the disk loses linear momentum through the asymmetric jet-counterjet system it powers. The dynamics of the accelerated Kepler problem is analyzed using physical as well as parabolic coordinates. The latter naturally separate the problem's Hamiltonian into two unidimensional Hamiltonians. In particular, we identify the origin of the secular resonance in the accelerated Kepler problem and determine analytically the radius of stability boundary of initially circular orbits that are of particular interest to the problem of radial migration in binary systems as well as to the truncation of accretion disks through stellar jet acceleration.
The Characteristics of a Model Technology Education Teacher
Kaufman, Andrew R.; Warner, Scott A.; Buechele, Jessica R.
2011-01-01
The things that make the quality of a teacher stand out can cover a wide range of characteristics, actions, words, and experiences. The mark left on a student by a teacher, for good or bad, is written in an ink that will last a lifetime. This article describes a study that identifies the characteristics of exceptional technology education…
Neuroendocrine pathways mediating nutritional acceleration of puberty: insights from ruminant models
Marcel eAmstalden
2011-12-01
Full Text Available The pubertal process is characterized by an activation of physiological events within the hypothalamic-adenohypophyseal-gonadal axis which culminate in reproductive competence. Excessive weight gain and adiposity during the juvenile period is associated with accelerated onset of puberty in females. The mechanisms and pathways by which excess energy balance advances puberty are unclear, but appear to involve an early escape from estradiol negative feedback and early initiation of high frequency episodic gonadotropin-releasing hormone (GnRH secretion. Hypothalamic neurons, particularly neuropeptide Y and proopiomelanocortin neurons are likely important components of the pathway sensing and transmitting metabolic information to the control of GnRH secretion. Kisspeptin neurons may also have a role as effector neurons integrating metabolic and gonadal steroid feedback effects on GnRH secretion at the time of puberty. Recent studies indicate that leptin-responsive neurons within the ventral premammillary nucleus play a critical role in pubertal progression and challenge the relevance of kisspeptin neurons in this process. Nevertheless, the nutritional control of puberty is likely to involve an integration of major sensor and effector pathways that interact with modulatory circuitries for a fine control of GnRH neuron function. In this review, observations made in ruminant species are emphasized for a comparative perspective.
INFILTRATION KINETICS MODEL OF LIQUID METAL INTO A FIBROUS PREFORM IN CENTRIFUGAL ACCELERATING FIELD
无
2001-01-01
The infiltration kinetics of the metal melt into a fibrous preform in centrifugal accelerating field is analyzed on the basis of Da rcy's law and the assumption that the fibrous preform is treated as “bundle of capillaries”. The critical rotating speed is analyzed with the established mo del. The influences of the metal melt mass,the rotating speed of the equipmen t,the casting height, the original outer radius of the metal melt and the fibrou s volume fraction in fibrous preform on infilatration are studied. The results show that the critical rotating speed is dependent on critical pressure, castin g height, metal melt mass and the character of fibrous preform. With the incr ease in the metal melt mass, rotating speed of the equipment and original outer radius of the metal melt, or the decrease in casting height and fibrous volume f raction in fibrous of the metal melt,or the decrease in casting height and fibro us volume fraction in fibrous preform,infiltration of metal melt for fibrous pre form becomes easier.
Transcutaneous carbon dioxide application accelerates muscle injury repair in rat models.
Akahane, Shiho; Sakai, Yoshitada; Ueha, Takeshi; Nishimoto, Hanako; Inoue, Miho; Niikura, Takahiro; Kuroda, Ryosuke
2017-05-01
Skeletal muscle injuries are commonly observed in sports and traumatology medicine. Previously, we demonstrated that transcutaneous application of carbon dioxide (CO2) to lower limbs increased the number of muscle mitochondria and promoted muscle endurance. Therefore, we aimed to investigate whether transcutaneous CO2 application could enhance recovery from muscle injury. Tibialis anterior muscle damage was induced in 27 Sprague Dawley rats via intramuscular injection of bupivacaine. After muscle injury, rats were randomly assigned to transcutaneous CO2-treated or -untreated groups. From each group, three rats were sacrificed at weeks one, two, four and six. At each time point, histology and immunofluorescence analyses were performed, and changes in muscle weight, muscle weight/body weight ratio, muscle fibre circumference, gene expression levels and capillary density were measured. Injured muscle fibres were completely repaired at week six in the CO2-treated group but only partially repaired in the untreated group. The repair of basement and plasma membranes did not differ significantly between groups. However, expression levels of genes and proteins related to muscle protein synthesis were significantly higher in the CO2-treated group and significantly more capillaries four weeks after injury. Transcutaneous CO2 application can accelerate recovery after muscle injury in rats.
The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry
Kate Brody Nooner
2012-10-01
Full Text Available The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk and resilience across the lifespan. To attain these objectives, sufficiently powered datasets with broad and deep phenotypic characterization, state-of-the-art neuroimaging, and genetic samples must be generated and made openly available to the scientific community. The enhanced Nathan Kline Institute Rockland Sample (NKI-RS is a response to this need. NKI-RS is an ongoing, institutionally-centered endeavor aimed at creating a large-scale (N>1000, deeply phenotyped, community-ascertained, lifespan sample (ages 6-85 years old with advanced neuroimaging and genetics. These data will be publically shared, openly and prospectively (i.e., on a weekly basis. Herein, we describe the conceptual basis of the NKI-RS, including study design, sampling considerations, and steps to synchronize phenotypic and neuroimaging assessment. Additionally, we describe our process for sharing the data with the scientific community while protecting participant confidentiality, maintaining an adequate database, and certifying data integrity. The pilot phase of the NKI-RS, including challenges in recruiting, characterizing, imaging, and sharing data, is discussed while also explaining how this experience informed the final design of the enhanced NKI-RS. It is our hope that familiarity with the conceptual underpinnings of the enhanced NKI-RS will facilitate harmonization with future data collection efforts aimed at advancing psychiatric neuroscience and nosology.
De Souza, Raquel; Spence, Tara; Huang, Huang; Allen, Christine
2015-12-10
The majority of animal models of cancer have performed poorly in terms of predicting clinical performance of new therapeutics, which are most often first evaluated in patients with advanced, metastatic disease. The development and use of metastatic models of cancer may enhance clinical translatability of preclinical studies focused on the development of nanotechnology-based drug delivery systems and macromolecular therapeutics, potentially accelerating their clinical implementation. It is recognized that the development and use of such models are not without challenge. Preclinical imaging tools offer a solution by allowing temporal and spatial characterization of metastatic lesions. This paper provides a review of imaging methods applicable for evaluation of novel therapeutics in clinically relevant models of advanced cancer. An overview of currently utilized models of oncology in small animals is followed by image-based development and characterization of visceral metastatic cancer models. Examples of imaging tools employed for metastatic lesion detection, evaluation of anti-tumor and anti-metastatic potential and biodistribution of novel therapies, as well as the co-development and/or use of imageable surrogates of response, are also discussed. While the focus is on development of macromolecular and nanotechnology-based therapeutics, examples with small molecules are included in some cases to illustrate concepts and approaches that can be applied in the assessment of nanotechnologies or macromolecules.
Underbody Blast Models of TBI Caused by Hyper-Acceleration and Secondary Head Impact
2016-02-01
synaptophysin, and synaptophilin are three proteins crucial for maintaining functional synapses. Immunoblot measurements of these proteins revealed a...energy test- ing of small projectiles, ranging in shape and size, showed the steel sphere produced the highest impact energy and the most consistent...impact characteristics. Additional tests confirmed the steel sphere produced linear and rotational motions on the rat’s head while remaining within a
A cold plasma jet accelerates wound healing in a murine model of full-thickness skin wounds.
Schmidt, Anke; Bekeschus, Sander; Wende, Kristian; Vollmar, Brigitte; von Woedtke, Thomas
2017-02-01
Cold plasma has been successfully applied in several fields of medicine that require, for example, pathogen inactivation, implant functionalization or alteration of cellular activity. Previous studies have provided evidence that plasma supports the healing of wounds owing to its beneficial mixtures of reactive species and modulation of inflammation in cells and tissues. To investigate the wound healing activity of an atmospheric pressure plasma jet in vivo, we examined the cold plasma's efficacy on dermal regeneration in a murine model of dermal full-thickness ear wound. Over 14 days, female mice received daily plasma treatment. Quantitative analysis by transmitted light microscopy demonstrated a significantly accelerated wound re-epithelialization at days 3-9 in comparison with untreated controls. In vitro, cold plasma altered keratinocyte and fibroblast migration, while both cell types showed significant stimulation resulting in accelerated closure of gaps in scratch assays. This plasma effect correlated with the downregulation of the gap junctional protein connexin 43 which is thought to be important in the regulation of wound healing. In addition, plasma induced profound changes in adherence junctions and cytoskeletal dynamics as shown by downregulation of E-cadherin and several integrins as well as actin reorganization. Our results theorize cold plasma to be a beneficial treatment option supplementing existing wound therapies.
Introduction to Microwave Linear [Accelerators
Whittum, David H
1999-01-04
The elements of microwave linear accelerators are introduced starting with the principles of acceleration and accelerating structures. Considerations for microwave structure modeling and design are developed from an elementary point of view. Basic elements of microwave electronics are described for application to the accelerator circuit and instrumentation. Concepts of beam physics are explored together with examples of common beamline instruments. Charged particle optics and lattice diagnostics are introduced. Considerations for fixed-target and colliding-beam experimentation are summarized.
Wikramanayake, Tongyu Cao; Villasante, Alexandra C; Mauro, Lucia M; Nouri, Keyvan; Schachner, Lawrence A; Perez, Carmen I; Jimenez, Joaquin J
2013-05-01
Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects of antineoplastic chemotherapy for which there is no effective interventional approach. A low-level laser (LLL) device, the HairMax LaserComb®, has been cleared by the FDA to treat androgenetic alopecia. Its effects may be extended to other settings; we have demonstrated that LaserComb treatment induced hair regrowth in a mouse model for alopecia areata. In the current study, we tested whether LLL treatment could promote hair regrowth in a rat model for CIA. Chemotherapy agents cyclophosphamide, etoposide, or a combination of cyclophosphamide and doxorubicin were administered in young rats to induce alopecia, with or without LLL treatment. As expected, 7-10 days later, all the rats developed full body alopecia. However, rats receiving laser treatment regrew hair 5 days earlier than rats receiving chemotherapy alone or sham laser treatment (with the laser turned off). The accelerated hair regrowth in laser-treated rats was confirmed by histology. In addition, LLL treatment did not provide local protection to subcutaneously injected Shay chloroleukemic cells. Taken together, our results demonstrated that LLL treatment significantly accelerated hair regrowth after CIA without compromising the efficacy of chemotherapy in our rat model. Our results suggest that LLL should be explored for the treatment of CIA in clinical trials because LLL devices for home use (such as the HairMax LaserComb®) provide a user-friendly and noninvasive approach that could be translated to increased patient compliance and improved efficacy.
NIIEFA accelerators for applied purposes
Vorogushin, M. F.; Strokach, A. P.; Filatov, O. G.
2016-12-01
Since the foundation of the institute, we have designed and delivered more than three hundred different accelerators to Russia and abroad: cyclotrons, linear accelerators, and neutron generators. The technical characteristics of our equipment makes it competitive on the international market. Here we present the application, main parameters, and status of accelerators manufactured by NIIEFA, as well as prospects for the development of electrophysical systems for applied purposes.
Accelerating anisotropic cosmological model in f(R,T) theory of gravity
Santhi Kumar, R.; Satyannarayana, B.
2017-10-01
Field equations in a modified theory of gravitation proposed by Harko et al. (Phys Rev D 84:024020, 8) are obtained with the aid of a spatially homogeneous and anisotropic LRS Bianchi type-I metric. Cosmological models corresponding to false vacuum and dust universe are obtained. Some physical and kinematical properties of each of the models are discussed. These models may be physically significant for discussion at an early stage of evolution of the universe.
Pesaran, Ahmad; Zhang, Chao; Kim, Gi-heon; Santhanagopalan, Shriram
2015-06-10
The physical and chemical phenomena occurring in a battery are many and complex and in many different scales. Without a better knowledge of the interplay among the multi-physics occurring across the varied scales, it is very challenging and time consuming to design long-lasting, high-performing, safe, affordable large battery systems, enabling electrification of the vehicles and modernization of the grid. The National Renewable Energy Laboratory, a U.S. Department of Energy laboratory, has been developing thermal and electrochemical models for cells and battery packs. Working with software producers, carmakers, and battery developers, computer-aided engineering tools have been developed that can accelerate the electrochemical and thermal design of batteries, reducing time to develop and optimize them and thus reducing the cost of the system. In the past couple of years, we initiated a project to model the mechanical response of batteries to stress, strain, fracture, deformation, puncture, and crush and then link them to electrochemical and thermal models to predict the response of a battery. This modeling is particularly important for understanding the physics and processes that happen in a battery during a crush-inducing vehicle crash. In this paper, we provide an overview of electrochemical-thermal-mechanical models for battery system understanding and designing.
Gamble, Ed; Holzmann, Gerard
2011-01-01
Part of the US DOT investigation of Toyota SUA involved analysis of the throttle control software. JPL LaRS applied several techniques, including static analysis and logic model checking, to the software. A handful of logic models were built. Some weaknesses were identified; however, no cause for SUA was found. The full NASA report includes numerous other analyses
Self-consistent core-pedestal transport simulations with neural network accelerated models
Meneghini, O.; Smith, S. P.; Snyder, P. B.; Staebler, G. M.; Candy, J.; Belli, E.; Lao, L.; Kostuk, M.; Luce, T.; Luda, T.; Park, J. M.; Poli, F.
2017-08-01
Fusion whole device modeling simulations require comprehensive models that are simultaneously physically accurate, fast, robust, and predictive. In this paper we describe the development of two neural-network (NN) based models as a means to perform a snon-linear multivariate regression of theory-based models for the core turbulent transport fluxes, and the pedestal structure. Specifically, we find that a NN-based approach can be used to consistently reproduce the results of the TGLF and EPED1 theory-based models over a broad range of plasma regimes, and with a computational speedup of several orders of magnitudes. These models are then integrated into a predictive workflow that allows prediction with self-consistent core-pedestal coupling of the kinetic profiles within the last closed flux surface of the plasma. The NN paradigm is capable of breaking the speed-accuracy trade-off that is expected of traditional numerical physics models, and can provide the missing link towards self-consistent coupled core-pedestal whole device modeling simulations that are physically accurate and yet take only seconds to run.
Gamble, Ed; Holzmann, Gerard
2011-01-01
Part of the US DOT investigation of Toyota SUA involved analysis of the throttle control software. JPL LaRS applied several techniques, including static analysis and logic model checking, to the software. A handful of logic models were built. Some weaknesses were identified; however, no cause for SUA was found. The full NASA report includes numerous other analyses
Olcay Akman
2010-07-01
Full Text Available We implement genetic algorithm based predictive model building as an alternative to the traditional stepwise regression. We then employ the Information Complexity Measure (ICOMP as a measure of model fitness instead of the commonly used measure of R-square. Furthermore, we propose some modifications to the genetic algorithm to increase the overall efficiency.
$Om$ diagnostic applied to scalar field models and slowing down of cosmic acceleration
Shahalam, M; Agarwal, Abhineet
2015-01-01
We apply the $Om$ diagnostic to models for dark energy based on scalar fields. In case of the power law potentials, we demonstrate the possibility of slowing down the expansion of the Universe around the present epoch for a specific range in the parameter space. For these models, we also examine the issues concerning the age of Universe. We use the $Om$ diagnostic to distinguish the $\\Lambda$CDM model from non minimally coupled scalar field, phantom field and generic quintessence models. Our study shows that the $Om$ has zero, positive and negative curvatures for $\\Lambda$CDM, phantom and quintessence models respectively. We use an integrated data base (SN+Hubble+BAO+CMB) for bservational analysis and demonstrate that $Om$ is a useful diagnostic to apply to observational data.
Federal Laboratory Consortium — The Horizontal Accelerator (HA) Facility is a versatile research tool available for use on projects requiring simulation of the crash environment. The HA Facility is...
On characteristic modeling of a class of flight vehicles’attitude dynamics
无
2010-01-01
The characteristic modeling problem of flight vehicles’attitude dynamics is considered in this paper.In terms of the affine nonlinear system with triangle form of flight vehicles’attitude dynamics,a general method is presented to compress the dynamics into the characteristic model parameters,by introducing the time scale of nonlinear systems and a class of system states related compress functions.The parameter region and limit of the characteristic model are also given.From the given parameter region it is seen that the bound of the characteristic model parameters is dependent on the sampling period,the modeling error,the system order and the system change rate.The modeling error of the established characteristic model can be arbitrarily small according to the control precision,showing the difference between the characteristic model and other model reduction methods,that is,no system information is lost using this approach.On the basis of this modeling approach,the characteristic model of the flexible satellite attitude is established,as well as the bound and limit of the parameters,which sets a theoretical foundation for characteristic model based control design of flight vehicles.
Hübner, K
1999-01-01
An overview of the various schemes for electron-positron linear colliders is given and the status of the development of key components and the various test facilities is given. The present studies of muon-muon colliders and very large hadron colliders are summarized including the plans for component development and tests. Accelerator research and development to achieve highest gradients in linear accelerators is outlined. (44 refs).
Ceballos, C; Esposito, J
2009-07-01
The SPES-BNCT ongoing project of the Istituto Nazionale di Fisica Nucleare (INFN) is aimed at the construction at the Laboratori Nazionali di Legnaro (LNL) of an accelerator-based (AB), high-flux thermal neutron beam facility devoted to boron neutron capture therapy (BNCT) experimental treatment of extended skin melanoma, in the framework of SPES (selective production of exotic species) project. The neutron source will be produced via the (9)Be(p,xn) reactions by a 5 MeV, 30 mA proton beam into a thick beryllium target. The resulting neutron spectrum is slowed down using a beam shaping assembly (BSA), for which modeling is in an advanced neutronic design stage. An overview on the BSA current status, based on the Be neutron converter prototype designed and already constructed, is reported.
Smoller, Joel
2012-01-01
We prove that the Einstein equations in Standard Schwarzschild Coordinates close to form a system of three ordinary differential equations for a family of spherically symmetric, self-similar expansion waves, and the critical ($k=0$) Friedmann universe associated with the pure radiation phase of the Standard Model of Cosmology (FRW), is embedded as a single point in this family. Removing a scaling law and imposing regularity at the center, we prove that the family reduces to an implicitly defined one parameter family of distinct spacetimes determined by the value of a new {\\it acceleration parameter} $a$, such that $a=1$ corresponds to FRW. We prove that all self-similar spacetimes in the family are distinct from the non-critical $k\
Badal Soler, Andreu
2008-01-01
Els programes de simulació Monte Carlo de caràcter general s'utilitzen actualment en una gran varietat d'aplicacions.Tot i això, els models geomètrics implementats en la majoria de programes imposen certes limitacions a la forma dels objectes que es poden definir. Aquests models no són adequats per descriure les superfícies arbitràries que es troben en estructures anatòmiques o en certs aparells mèdics i, conseqüentment, algunes aplicacions que requereixen l'ús de models geomètrics molt detal...
Avelino, Arturo; Nucamendi, Ulises, E-mail: avelino@ifm.umich.mx, E-mail: ulises@ifm.umich.mx [Instituto de Fisica y Matematicas, Universidad Michoacana de San Nicolas de Hidalgo, Edificio C-3, Ciudad Universitaria, CP. 58040 Morelia, Michoacan (Mexico)
2009-04-15
We test a cosmological model which the only component is a pressureless fluid with a constant bulk viscosity as an explanation for the present accelerated expansion of the universe. We classify all the possible scenarios for the universe predicted by the model according to their past, present and future evolution and we test its viability performing a Bayesian statistical analysis using the SCP ''Union'' data set (307 SNe Ia), imposing the second law of thermodynamics on the dimensionless constant bulk viscous coefficient {zeta}-tilde and comparing the predicted age of the universe by the model with the constraints coming from the oldest globular clusters. The best estimated values found for {zeta}-tilde and the Hubble constant H{sub 0} are: {zeta}-tilde = 1.922{+-}0.089 and H{sub 0} = 69.62{+-}0.59 (km/s)Mpc{sup -1} with a {chi}{sup 2}{sub min} = 314 ({chi}{sup 2}{sub d.o.f} = 1.031). The age of the universe is found to be 14.95{+-}0.42 Gyr. We see that the estimated value of H{sub 0} as well as of {chi}{sup 2}{sub d.o.f} are very similar to those obtained from {Lambda}CDM model using the same SNe Ia data set. The estimated age of the universe is in agreement with the constraints coming from the oldest globular clusters. Moreover, the estimated value of {zeta}-tilde is positive in agreement with the second law of thermodynamics (SLT). On the other hand, we perform different forms of marginalization over the parameter H{sub 0} in order to study the sensibility of the results to the way how H{sub 0} is marginalized. We found that it is almost negligible the dependence between the best estimated values of the free parameters of this model and the way how H{sub 0} is marginalized in the present work. Therefore, this simple model might be a viable candidate to explain the present acceleration in the expansion of the universe.
Dzyuba, A.; /Fermilab /Novosibirsk State U.; Romanenko, A.; /Fermilab; Cooley, L.D.; /Fermilab
2010-07-13
A model for the onset of the reduction in SRF cavity quality factor, the so-called Q-drop, at high accelerating electric fields is presented. Since magnetic fields at the cavity equator are tied to accelerating electric fields by a simple geometric factor, the onset of magnetic flux penetration determines the onset of Q-drop. We consider breakdown of the surface barrier at triangular grooves to predict the magnetic field of first flux penetration H{sub pen}. Such defects were argued to be the worst case by Buzdin and Daumens, [1998 Physica C 294 257], whose approach, moreover, incorporates both the geometry of the groove and local contamination via the Ginzburg-Landau parameter {kappa}. Since previous Q-drop models focused on either topography or contamination alone, the proposed model allows new comparisons of one effect in relation to the other. The model predicts equivalent reduction of H{sub pen} when either roughness or contamination were varied alone, so smooth but dirty surfaces limit cavity performance about as much as rough but clean surfaces do. Still lower H{sub pen} was predicted when both effects were combined, i.e. contamination should exacerbate the negative effects of roughness and vice-versa. To test the model with actual data, coupons were prepared by buffered chemical polishing and electropolishing, and stylus profilometry was used to obtain distributions of angles. From these data, curves for surface resistance generated by simple flux flow as a function of magnetic field were generated by integrating over the distribution of angles for reasonable values of {kappa}. This showed that combined effects of roughness and contamination indeed reduce the Q-drop onset field by {approx}20%, and that that contamination contributes to Q-drop as much as roughness. The latter point may be overlooked by SRF cavity research, since access to the cavity interior by spectroscopy tools is very difficult, whereas optical images have become commonplace. The model