WorldWideScience

Sample records for accelerated titration designs

  1. Designing reliability into accelerators

    International Nuclear Information System (INIS)

    Future accelerators will have to provide a high degree of reliability. Quality must be designed in right from the beginning and must remain a central theme throughout the project. The problem is similar to the problems facing US industry today, and examples of the successful application of quality engineering will be given. Different aspects of an accelerator project will be addressed: Concept, Design, Motivation, Management Techniques, and Fault Diagnosis. The importance of creating and maintaining a coherent team will be stressed

  2. Superconducting accelerator magnet design

    International Nuclear Information System (INIS)

    Superconducting dipoles, quadrupoles and correction magnets are necessary to achieve the high magnetic fields required for big accelerators presently in construction or in the design phase. Different designs of superconducting accelerator magnets are described and the designs chosen at the big accelerator laboratories are presented. The most frequently used cosθ coil configuration is discussed in detail. Approaches for calculating the magnetic field quality including coil end fields are presented. Design details of the cables, coils, mechanical structures, yokes, helium vessels and cryostats including thermal radiation shields and support structures used in superconducting magnets are given. Necessary material properties are mentioned. Finally, the main results of magnetic field measurements and quench statistics are presented. (orig.)

  3. Project X: Accelerator Reference Design

    CERN Document Server

    Holmes, S D; Chase, B; Gollwitzer, K; Johnson, D; Kaducak, M; Klebaner, A; Kourbanis, I; Lebedev, V; Leveling, A; Li, D; Nagaitsev, S; Ostroumov, P; Pasquinelli, R; Patrick, J; Prost, L; Scarpine, V; Shemyakin, A; Solyak, N; Steimel, J; Yakovlev, V; Zwaska, R

    2013-01-01

    Part 1 of "Project X: Accelerator Reference Design, Physics Opportunities, Broader Impacts". Part 1 contains the volume Preface and a description of the conceptual design for a high-intensity proton accelerator facility being developed to support a world-leading program of Intensity Frontier physics over the next two decades at Fermilab. Subjects covered include performance goals, the accelerator physics design, and the technological basis for such a facility.

  4. Software for virtual accelerator designing

    International Nuclear Information System (INIS)

    The article discusses appropriate technologies for software implementation of the Virtual Accelerator. The Virtual Accelerator is considered as a set of services and tools enabling transparent execution of computational software for modeling beam dynamics in accelerators on distributed computing resources. Distributed storage and information processing facilities utilized by the Virtual Accelerator make use of the Service-Oriented Architecture (SOA) according to a cloud computing paradigm. Control system tool-kits (such as EPICS, TANGO), computing modules (including high-performance computing), realization of the GUI with existing frameworks and visualization of the data are discussed in the paper. The presented research consists of software analysis for realization of interaction between all levels of the Virtual Accelerator and some samples of middle-ware implementation. A set of the servers and clusters at St.-Petersburg State University form the infrastructure of the computing environment for Virtual Accelerator design. Usage of component-oriented technology for realization of Virtual Accelerator levels interaction is proposed. The article concludes with an overview and substantiation of a choice of technologies that will be used for design and implementation of the Virtual Accelerator. (authors)

  5. Designing reliability into accelerators

    International Nuclear Information System (INIS)

    For the next generation of high performance, high average luminosity colliders, the ''factories,'' reliability engineering must be introduced right at the inception of the project and maintained as a central theme throughout the project. There are several aspects which will be addressed separately: Concept; design; motivation; management techniques; and fault diagnosis

  6. Rational Catalyst Design of Titanium-Silica Materials Aided by Site-Specific Titration Tools

    Science.gov (United States)

    Eaton, Todd Robert

    between particle and crystal size, as obtained from XRD. In the course of establishing these relationships we've gained the knowledge of how to control TiO x structure, which enables the design of new and better catalysts. Understanding the synthesis-structure-function relationships allow for the design of a tandem photo/thermocatalytic reaction system for producing and consuming H2O2. By partially overcoating a TiO 2 photocatalyst with a ˜2 nm silica layer we observe a 56-fold rate improvement compared to bare-TiO2 for H2O2 synthesis from the proton-assisted reduction of O2. Addition of metal-SiO2 thermocatalysts (metal=Ti, Nb, or Ta) with sites needed for H2O2 activation creates a tandem system wherein the H2O2 produced in situ is utilized for alkene epoxidation. Compared to a thermocatalytic-only system, the tandem system accelerates epoxidation for cis-cyclooctene(11x faster), styrene(20x) and 1-octene(30x). This approach demonstrates a means for epoxidation with O2 that avoids H2O2 purification and transport, simplifies the total process, provides new opportunities for control by independent H2O2 production and consumption in the same reactor, and enhances rates relative to thermocatalytic-only epoxidation by intimately coupling H2O2 generation and consumption. Critically, establishment of titanium-silica synthesis-structure-function relationships enables the design of new catalysts and systems that are less energy- and material-intensive, leading towards more sustainable chemistry.

  7. Injector Design for Advanced Accelerators

    Science.gov (United States)

    Henestroza, Enrique; Faltens, A.

    1996-11-01

    Accelerator designs intended to provide acceleration at a much lower cost per Joule than the ILSE or ELISE designs are under study. For these designs, which typically have many beams, an injector of significantly lower cost is needed. A goal, which from our design appears to be achievable, is to reduce the transverse dimension to half that of the 2 MeV, 800 mA ILSE injector(E. Henestroza, ``Injectors for Heavy Ion Fusion", Proc. of the 11th International Wkshp. on Laser Interaction and Related Plasma Phenomena, 1993.) while generating about the same current. A single channel of a lower cost injector includes an 800 kV column, accelerating a 700 mA beam extracted from a potassium source of 4 cm radius by a 120 kV electrode. The beam passes into a superconducting 7 T solenoid of 15 cm aperture and 15 cm length. This high-field solenoid provides the focusing needed for a small beam without increasing the electric field gradient. The injector and its matching section, also designed, fit within a 12 cm radius, which is small enough to allow construction of attractive multi-beam injectors. We will present solutions for the generation and transport of 700 mA potassium beams of up to 1.6 MeV within the same transverse constraint.

  8. Development of Karl Fischer titration method using quality by design concept

    Directory of Open Access Journals (Sweden)

    Kostić Nađa M.

    2012-01-01

    Full Text Available Modern trends in drug quality control are moving toward incorporating quality into the method during its development. That course is in accordance with Quality by Design (QbD concept defined by ICH Q 8 (R2 guideline. This implies that the method development begins by defining the method goals and collecting the relevant data, i.e. analyzing the properties of a given active pharmaceutical ingredient and evaluating the optimal experimental conditions. It is followed by a risk assessment defined by systematic robustness testing with the application of experimental design, while the final confirmation of the method reliability is done through the complete validation tests. In this paper, development of Karl Fischer titration for water determination in active pharmaceutical substance clindamycin phosphate is presented. Karl Fischer titration (KFT is a widely used method in the pharmaceutical industry for determination of water content. For the analyzed substance, the European Pharmacopoeia suggests a relatively large amount of samples for the determination of water, so the objective of this study is to confirm the applicability of the developed method for the determination of water in small amount of samples applying QbD approach. According to QbD rules, detail development of coulometric Karl Fischer titration for water determination in clindamycin phosphate was done. For robustness testing fractional factorial design 24-1 was successful applied and confirmed that method was robust. Robustness was evaluated using statistical and graphical methods. Also, design space was defined so the region, in which factors could be changed without significant changes in water content, was defined. At the end, other validation parameters were determined and it was proved that analytical test system was capable of providing useful and valid analytical data.

  9. COMPASS Accelerator Design Technical Overview

    Energy Technology Data Exchange (ETDEWEB)

    Nanni, Emilio; Dolgashev, Valery; Tantawi, Sami; Neilson, Jeff; /SLAC

    2016-03-14

    This report is a survey of technical options for generating a MeV-class accelerator for space based science applications. The survey was performed focusing on the primary technical requirements of the accelerator in the context of a satellite environment with its unique challenges of limited electrical power (PE), thermal isolation, dimensions, payload requirement and electrical isolation.

  10. The Spallation Neutron Source accelerator system design

    Science.gov (United States)

    Henderson, S.; Abraham, W.; Aleksandrov, A.; Allen, C.; Alonso, J.; Anderson, D.; Arenius, D.; Arthur, T.; Assadi, S.; Ayers, J.; Bach, P.; Badea, V.; Battle, R.; Beebe-Wang, J.; Bergmann, B.; Bernardin, J.; Bhatia, T.; Billen, J.; Birke, T.; Bjorklund, E.; Blaskiewicz, M.; Blind, B.; Blokland, W.; Bookwalter, V.; Borovina, D.; Bowling, S.; Bradley, J.; Brantley, C.; Brennan, J.; Brodowski, J.; Brown, S.; Brown, R.; Bruce, D.; Bultman, N.; Cameron, P.; Campisi, I.; Casagrande, F.; Catalan-Lasheras, N.; Champion, M.; Champion, M.; Chen, Z.; Cheng, D.; Cho, Y.; Christensen, K.; Chu, C.; Cleaves, J.; Connolly, R.; Cote, T.; Cousineau, S.; Crandall, K.; Creel, J.; Crofford, M.; Cull, P.; Cutler, R.; Dabney, R.; Dalesio, L.; Daly, E.; Damm, R.; Danilov, V.; Davino, D.; Davis, K.; Dawson, C.; Day, L.; Deibele, C.; Delayen, J.; DeLong, J.; Demello, A.; DeVan, W.; Digennaro, R.; Dixon, K.; Dodson, G.; Doleans, M.; Doolittle, L.; Doss, J.; Drury, M.; Elliot, T.; Ellis, S.; Error, J.; Fazekas, J.; Fedotov, A.; Feng, P.; Fischer, J.; Fox, W.; Fuja, R.; Funk, W.; Galambos, J.; Ganni, V.; Garnett, R.; Geng, X.; Gentzlinger, R.; Giannella, M.; Gibson, P.; Gillis, R.; Gioia, J.; Gordon, J.; Gough, R.; Greer, J.; Gregory, W.; Gribble, R.; Grice, W.; Gurd, D.; Gurd, P.; Guthrie, A.; Hahn, H.; Hardek, T.; Hardekopf, R.; Harrison, J.; Hatfield, D.; He, P.; Hechler, M.; Heistermann, F.; Helus, S.; Hiatt, T.; Hicks, S.; Hill, J.; Hill, J.; Hoff, L.; Hoff, M.; Hogan, J.; Holding, M.; Holik, P.; Holmes, J.; Holtkamp, N.; Hovater, C.; Howell, M.; Hseuh, H.; Huhn, A.; Hunter, T.; Ilg, T.; Jackson, J.; Jain, A.; Jason, A.; Jeon, D.; Johnson, G.; Jones, A.; Joseph, S.; Justice, A.; Kang, Y.; Kasemir, K.; Keller, R.; Kersevan, R.; Kerstiens, D.; Kesselman, M.; Kim, S.; Kneisel, P.; Kravchuk, L.; Kuneli, T.; Kurennoy, S.; Kustom, R.; Kwon, S.; Ladd, P.; Lambiase, R.; Lee, Y. Y.; Leitner, M.; Leung, K.-N.; Lewis, S.; Liaw, C.; Lionberger, C.; Lo, C. C.; Long, C.; Ludewig, H.; Ludvig, J.; Luft, P.; Lynch, M.; Ma, H.; MacGill, R.; Macha, K.; Madre, B.; Mahler, G.; Mahoney, K.; Maines, J.; Mammosser, J.; Mann, T.; Marneris, I.; Marroquin, P.; Martineau, R.; Matsumoto, K.; McCarthy, M.; McChesney, C.; McGahern, W.; McGehee, P.; Meng, W.; Merz, B.; Meyer, R.; Meyer, R.; Miller, B.; Mitchell, R.; Mize, J.; Monroy, M.; Munro, J.; Murdoch, G.; Musson, J.; Nath, S.; Nelson, R.; Nelson, R.; O`Hara, J.; Olsen, D.; Oren, W.; Oshatz, D.; Owens, T.; Pai, C.; Papaphilippou, I.; Patterson, N.; Patterson, J.; Pearson, C.; Pelaia, T.; Pieck, M.; Piller, C.; Plawski, T.; Plum, M.; Pogge, J.; Power, J.; Powers, T.; Preble, J.; Prokop, M.; Pruyn, J.; Purcell, D.; Rank, J.; Raparia, D.; Ratti, A.; Reass, W.; Reece, K.; Rees, D.; Regan, A.; Regis, M.; Reijonen, J.; Rej, D.; Richards, D.; Richied, D.; Rode, C.; Rodriguez, W.; Rodriguez, M.; Rohlev, A.; Rose, C.; Roseberry, T.; Rowton, L.; Roybal, W.; Rust, K.; Salazer, G.; Sandberg, J.; Saunders, J.; Schenkel, T.; Schneider, W.; Schrage, D.; Schubert, J.; Severino, F.; Shafer, R.; Shea, T.; Shishlo, A.; Shoaee, H.; Sibley, C.; Sims, J.; Smee, S.; Smith, J.; Smith, K.; Spitz, R.; Staples, J.; Stein, P.; Stettler, M.; Stirbet, M.; Stockli, M.; Stone, W.; Stout, D.; Stovall, J.; Strelo, W.; Strong, H.; Sundelin, R.; Syversrud, D.; Szajbler, M.; Takeda, H.; Tallerico, P.; Tang, J.; Tanke, E.; Tepikian, S.; Thomae, R.; Thompson, D.; Thomson, D.; Thuot, M.; Treml, C.; Tsoupas, N.; Tuozzolo, J.; Tuzel, W.; Vassioutchenko, A.; Virostek, S.; Wallig, J.; Wanderer, P.; Wang, Y.; Wang, J. G.; Wangler, T.; Warren, D.; Wei, J.; Weiss, D.; Welton, R.; Weng, J.; Weng, W.-T.; Wezensky, M.; White, M.; Whitlatch, T.; Williams, D.; Williams, E.; Wilson, K.; Wiseman, M.; Wood, R.; Wright, P.; Wu, A.; Ybarrolaza, N.; Young, K.; Young, L.; Yourd, R.; Zachoszcz, A.; Zaltsman, A.; Zhang, S.; Zhang, W.; Zhang, Y.; Zhukov, A.

    2014-11-01

    The Spallation Neutron Source (SNS) was designed and constructed by a collaboration of six U.S. Department of Energy national laboratories. The SNS accelerator system consists of a 1 GeV linear accelerator and an accumulator ring providing 1.4 MW of proton beam power in microsecond-long beam pulses to a liquid mercury target for neutron production. The accelerator complex consists of a front-end negative hydrogen-ion injector system, an 87 MeV drift tube linear accelerator, a 186 MeV side-coupled linear accelerator, a 1 GeV superconducting linear accelerator, a 248-m circumference accumulator ring and associated beam transport lines. The accelerator complex is supported by ~100 high-power RF power systems, a 2 K cryogenic plant, ~400 DC and pulsed power supply systems, ~400 beam diagnostic devices and a distributed control system handling ~100,000 I/O signals. The beam dynamics design of the SNS accelerator is presented, as is the engineering design of the major accelerator subsystems.

  11. The Spallation Neutron Source accelerator system design

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, S., E-mail: stuarth@fnal.gov [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States); Abraham, W. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Aleksandrov, A. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States); Allen, C. [Techsource, Inc., 1475 Central Avenue, Suite 250, Los Alamos, NM 87544-3291 (United States); Alonso, J. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Anderson, D. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States); Arenius, D. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Arthur, T. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States); Assadi, S. [Techsource, Inc., 1475 Central Avenue, Suite 250, Los Alamos, NM 87544-3291 (United States); Ayers, J.; Bach, P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Badea, V. [Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000 (United States); Battle, R. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States); Beebe-Wang, J. [Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000 (United States); Bergmann, B.; Bernardin, J.; Bhatia, T.; Billen, J.; Birke, T.; Bjorklund, E. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States); and others

    2014-11-01

    The Spallation Neutron Source (SNS) was designed and constructed by a collaboration of six U.S. Department of Energy national laboratories. The SNS accelerator system consists of a 1 GeV linear accelerator and an accumulator ring providing 1.4 MW of proton beam power in microsecond-long beam pulses to a liquid mercury target for neutron production. The accelerator complex consists of a front-end negative hydrogen-ion injector system, an 87 MeV drift tube linear accelerator, a 186 MeV side-coupled linear accelerator, a 1 GeV superconducting linear accelerator, a 248-m circumference accumulator ring and associated beam transport lines. The accelerator complex is supported by ∼100 high-power RF power systems, a 2 K cryogenic plant, ∼400 DC and pulsed power supply systems, ∼400 beam diagnostic devices and a distributed control system handling ∼100,000 I/O signals. The beam dynamics design of the SNS accelerator is presented, as is the engineering design of the major accelerator subsystems.

  12. Mechanical Design of Superconducting Accelerator Magnets

    OpenAIRE

    Toral, Fernando

    2015-01-01

    This paper is about the mechanical design of superconducting accelerator magnets. First, we give a brief review of the basic concepts and terms. In the following sections, we describe the particularities of the mechanical design of different types of superconducting accelerator magnets: solenoids, cos-theta, superferric, and toroids. Special attention is given to the pre-stress principle, which aims to avoid the appearance of tensile stresses in the superconducting coils. A case study on a co...

  13. DESIGN CRITERIA OF A PROTON FFAG ACCELERATOR.

    Energy Technology Data Exchange (ETDEWEB)

    RUGGIERO, A.G.

    2004-10-13

    There are two major issues that are to be confronted in the design of a Fixed-Field Alternating-Gradient (FFAG) accelerator, namely: (1) the stability of motion over the large momentum range needed for the beam acceleration, and (2) the compactness of the trajectories over the same momentum range to limit the dimensions of the magnets. There are a numbers of rules that need to be followed to resolve these issues. In particular, the magnet arrangement in the accelerator lattice and the distribution of the bending and focusing fields are to be set properly in accordance with these rules. In this report they describe four of these rules that ought to be applied for the optimum design of a FFAG accelerator, especially in the case of proton beams.

  14. The deuteron accelerator preliminary design for BISOL

    Science.gov (United States)

    Peng, S. X.; Zhu, F.; Wang, Z.; Gao, Y.; Guo, Z. Y.

    2016-06-01

    BISOL, which was named as Beijing_ISOL before (Cui et al., 2013), is the abbreviation of Beijing Isotope-Separation-On-Line neutron beam facility. It is proposed jointly by Peking University (PKU) and China Institute of Atomic Energy (CIAE) for basic science study and application. It is a double driven facility that can be driven by a reactor or a deuteron accelerator. The deuteron driver accelerator should accelerate the deuteron beam up to 40 MeV with maximum beam current of 10 mA. Proton beams up to 33 MeV and He2+ beams up to 81.2 MeV can also be accelerated in this accelerator. The accelerator can be operated on either CW (continuous waveform) or pulsed mode, and the ion energy can be adjusted in a wide range. The accelerator will also allow independent operation of the RIB (Radioactive Ion Beams) system. It will be mainly charged by PKU group. Details of the deuteron accelerator preliminary design for BISOL will be given in this paper.

  15. Mechanical Design of Superconducting Accelerator Magnets

    CERN Document Server

    Toral, F

    2014-01-01

    This paper is about the mechanical design of superconducting accelerator magnets. First, we give a brief review of the basic concepts and terms. In the following sections, we describe the particularities of the mechanical design of different types of superconducting accelerator magnets: solenoids, costheta, superferric, and toroids. Special attention is given to the pre-stress principle, which aims to avoid the appearance of tensile stresses in the superconducting coils. A case study on a compact superconducting cyclotron summarizes the main steps and the guidelines that should be followed for a proper mechanical design. Finally, we present some remarks on the measurement techniques.

  16. Nuclear data for designing the IFMIF accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Sugimoto, Masayoshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    The objective of the International Fusion Materials Irradiation Facility (IFMIF) and the design concept of the IFMIF accelerator system are described. The status of the nuclear data, especially for the deuteron-induced reactions, to qualify the system design is reviewed. The requests for the nuclear data compilation and/or evaluation are summarized. (author)

  17. Computing tools for accelerator design calculations

    Energy Technology Data Exchange (ETDEWEB)

    Fischler, M.; Nash, T.

    1984-01-01

    This note is intended as a brief, summary guide for accelerator designers to the new generation of commercial and special processors that allow great increases in computing cost effectiveness. New thinking is required to take best advantage of these computing opportunities, in particular, when moving from analytical approaches to tracking simulations. In this paper, we outline the relevant considerations.

  18. Design of a Compact Pulsed Power Accelerator

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A 100 kA/60 ns compact pulsed power accelerator was designed to study the influence to the X-pinch by the load. It is composed of a Marx generator, a combined pulse forming (PFL), a gas-filled V/N field distortion switch, a transfer line,

  19. FFAG Designs for Muon Collider Acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J. Scott [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.

    2014-01-13

    I estimate FFAG parameters for a muon collider with a 70mm longitudinal emittance. I do not discuss the lower emittance beam for a Higgs factory. I produce some example designs, giving only parameters relevant to estimating cost and performance. The designs would not track well, but the parameters of a good design will be close to those described. I compare these cost estimates to those for a fast-ramping synchrotron and a recirculating linear accelerator. I conclude that FFAGs do not appear to be cost-effective for the large longitudinal emittance in a high-energy muon collider.

  20. Design Concepts for Muon-Based Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Ryne, R. D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kirk, H. G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Palmer, R. B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Stratkis, D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Alexahin, Y. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Bross, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Gollwitzer, K. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Mokhov, N. V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Neuffer, D. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Palmer, M. A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Yonehara, K. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Snopok, P. [IIT, Chicago, IL (United States); Bogacz, A. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Roberts, T. J. [Muons Inc., Batavia, IL (United States); Delahaye, J. -P. [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-05-01

    Muon-based accelerators have the potential to enable facilities at both the Intensity and the Energy Frontiers. Muon storage rings can serve as high precision neutrino sources, and a muon collider is an ideal technology for a TeV or multi-TeV collider. Progress in muon accelerator designs has advanced steadily in recent years. In regard to 6D muon cooling, detailed and realistic designs now exist that provide more than 5 order-of-magnitude emittance reduction. Furthermore, detector performance studies indicate that with suitable pixelation and timing resolution, backgrounds in the collider detectors can be significantly reduced, thus enabling high-quality physics results. Thanks to these and other advances in design & simulation of muon systems, technology development, and systems demonstrations, muon storage-ring-based neutrino sources and a muon collider appear more feasible than ever before. A muon collider is now arguably among the most compelling approaches to a multi-TeV lepton collider. This paper summarizes the current status of design concepts for muon-based accelerators for neutrino factories and a muon collider.

  1. Design Concepts for Muon-Based Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Ryne, R. D.; et al.

    2015-05-01

    Muon-based accelerators have the potential to enable facilities at both the Intensity and the Energy Frontiers. Muon storage rings can serve as high precision neutrino sources, and a muon collider is an ideal technology for a TeV or multi-TeV collider. Progress in muon accelerator designs has advanced steadily in recent years. In regard to 6D muon cooling, detailed and realistic designs now exist that provide more than 5 order-of-magnitude emittance reduction. Furthermore, detector performance studies indicate that with suitable pixelation and timing resolution, backgrounds in the collider detectors can be significantly reduced thus enabling high quality physics results. Thanks to these and other advances in design & simulation of muon systems, technology development, and systems demonstrations, muon storage-ring-based neutrino sources and a muon collider appear more feasible than ever before. A muon collider is now arguably among the most compelling approaches to a multi-TeV lepton collider. This paper summarizes the current status of design concepts for muon-based accelerators for neutrino factories and a muon collider.

  2. Accelerating Science Driven System Design With RAMP

    Energy Technology Data Exchange (ETDEWEB)

    Wawrzynek, John [Univ. of California, Berkeley, CA (United States)

    2015-05-01

    Researchers from UC Berkeley, in collaboration with the Lawrence Berkeley National Lab, are engaged in developing an Infrastructure for Synthesis with Integrated Simulation (ISIS). The ISIS Project was a cooperative effort for “application-driven hardware design” that engages application scientists in the early parts of the hardware design process for future generation supercomputing systems. This project served to foster development of computing systems that are better tuned to the application requirements of demanding scientific applications and result in more cost-effective and efficient HPC system designs. In order to overcome long conventional design-cycle times, we leveraged reconfigurable devices to aid in the design of high-efficiency systems, including conventional multi- and many-core systems. The resulting system emulation/prototyping environment, in conjunction with the appropriate intermediate abstractions, provided both a convenient user programming experience and retained flexibility, and thus efficiency, of a reconfigurable platform. We initially targeted the Berkeley RAMP system (Research Accelerator for Multiple Processors) as that hardware emulation environment to facilitate and ultimately accelerate the iterative process of science-driven system design. Our goal was to develop and demonstrate a design methodology for domain-optimized computer system architectures. The tangible outcome is a methodology and tools for rapid prototyping and design-space exploration, leading to highly optimized and efficient HPC systems.

  3. Design, construction, and calibration of an isothermal titration calorimeter and its application in the study of the adsorption of phenolic compounds

    Science.gov (United States)

    Moreno-Piraján, Juan Carlos; Giraldo, Liliana

    2012-01-01

    An isothermal calorimetric titration was designed and built, and some of the results obtained are presented here. For this purpose, a Calvet heat-conducting microcalorimeter was developed and connected to a titration unit built for this experiment to record titration thermograms. The microcalorimeter was electrically calibrated to establish its sensitivity and reproducibility, obtaining K = 13.56 ± 0.21 W V-1. Additionally, the equipment was tested using the heat of neutralisation for the tris-hydroxymethyl-aminomethane-HCl (THAM-HCl) system, obtaining ΔH = -30.92 ± 0.03 kJ mol-1. The unit was assembled to obtain titration heats and the corresponding thermodynamic variables (ΔH, ΔG, ΔS, and Ke) with a system of phenolic derivatives-activated carbon (synthesised from potato peel).

  4. Accelerator Design Concept for Future Neutrino Facilities

    Energy Technology Data Exchange (ETDEWEB)

    ISS Accelerator Working Group; Zisman, Michael S; Berg, J. S.; Blondel, A.; Brooks, S.; Campagne, J.-E.; Caspar, D.; Cevata, C.; Chimenti, P.; Cobb, J.; Dracos, M.; Edgecock, R.; Efthymiopoulos, I.; Fabich, A.; Fernow, R.; Filthaut, F.; Gallardo, J.; Garoby, R.; Geer, S.; Gerigk, F.; Hanson, G.; Johnson, R.; Johnstone, C.; Kaplan, D.; Keil, E.; Kirk, H.; Klier, A.; Kurup, A.; Lettry, J.; Long, K.; Machida, S.; McDonald, K.; Meot, F.; Mori, Y.; Neuffer, D.; Palladino, V.; Palmer, R.; Paul, K.; Poklonskiy, A.; Popovic, M.; Prior, C.; Rees, G.; Rossi, C.; Rovelli, T.; Sandstrom, R.; Sevior, R.; Sievers, P.; Simos, N.; Torun, Y.; Vretenar, M.; Yoshimura, K.; Zisman, Michael S

    2008-02-03

    This document summarizes the findings of the Accelerator Working Group (AWG) of the International Scoping Study (ISS) of a Future Neutrino Factory and Superbeam Facility. The work of the group took place at three plenary meetings along with three workshops, and an oral summary report was presented at the NuFact06 workshop held at UC-Irvine in August, 2006. The goal was to reach consensus on a baseline design for a Neutrino Factory complex. One aspect of this endeavor was to examine critically the advantages and disadvantages of the various Neutrino Factory schemes that have been proposed in recent years.

  5. Accelerator design concept for future neutrino facilities

    CERN Document Server

    Apollonio, M; Blondel, A; Bogacz, A; Brooks, S; Campagne, Jean-Eric; Caspar, D; Cavata, C; Chimenti, P; Cobb, J; Dracos, M; Edgecock, R; Efthymiopoulos, I; Fabich, A; Fernow, R; Filthaut, F; Gallardo, J; Garoby, R; Geer, S; Gerigk, F; Hanson, G; Johnson, R; Johnstone, C; Kaplan, D; Keil, E; Kirk, H; Klier, A; Kurup, A; Lettry, J; Long, K; Machida, S; McDonald, K; Méot, F; Mori, Y; Neuffer, D; Palladino, V; Palmer, R; Paul, K; Poklonskiy, A; Popovic, M; Prior, C; Rees, G; Rossi, C; Rovelli, T; Sandström, R; Sevior, R; Sievers, P; Simos, N; Torun, Y; Vretenar, M; Yoshimura, K; Zisman, M S

    2009-01-01

    This document summarizes the findings of the Accelerator Working Group (AWG) of the International Scoping Study (ISS) of a Future Neutrino Factory and super-beam Facility. The work of the group took place at three plenary meetings along with three workshops, and an oral summary report was presented at the NuFact06 workshop held at UC-Irvine in August, 2006. The goal was to reach consensus on a baseline design for a Neutrino Factory complex. One aspect of this endeavor was to examine critically the advantages and disadvantages of the various Neutrino Factory schemes that have been proposed in recent years.

  6. Introduction to the overall physics design of CSNS accelerators

    Institute of Scientific and Technical Information of China (English)

    WANG Sheng; FANG Shou-Xian; FU Shi-Nian; LIU Wei-Bin; OUYANG Hua-Fu; QIN Qing; TANG Jing-Yu; WEI Jie

    2009-01-01

    The China Spallation Neutron Source(CSNS)is an accelerator-based facility.The accelerator of CSNS consists of a low energy linac,a Rapid Cycling Synchrotron(RCS)and two beam transport lines.The overall physits design of CSNS accelerator is described,including the design principle,the choice of the main parameters and design of each part of accelerators.The key problems of the physics design,such as beam loss and control,are also discussed.The interface between the different parts of accelerator,as well as between accelerator and target,are introduced.

  7. Conception design of helium ion FFAG accelerator with induction accelerating cavity

    CERN Document Server

    Huan-li, Luo; Xiang-qi, Wang; Hong-Liang, Xu

    2013-01-01

    In the recent decades of particle accelerator R&D area, fixed field alternating gradient (FFAG) accelerator has become a highlight for some advantages of its higher beam intensity and lower cost, although there are still some technical challenges. In this paper, FFAG accelerator is adopted to accelerate helium ion beam on the one hand for the study of helium embrittlement on fusion reactor envelope material and on the other hand for promoting the conception research and design of FFAG accelerator and exploring the possibility of developing high power FFAG accelerators. The conventional period focusing unit of helium ion FFAG accelerator and three-dimensional model of the large aperture combinatorial magnet by OPERA-TOSCA are given. For low energy and low revolution frequency, induction acceleration is proposed to replace conventional radio frequency(RF) acceleration for helium ion FFAG accelerator, which avoids the potential breakdown of acceleration field caused by wake field and improves the acceleratio...

  8. ILC Reference Design Report: Accelerator Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Phinney, Nan; /SLAC

    2007-12-14

    The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radiofrequency (SCRF) accelerating cavities. The use of the SCRF technology was recommended by the International Technology Recommendation Panel (ITRP) in August 2004 [1], and shortly thereafter endorsed by the International Committee for Future Accelerators (ICFA). In an unprecedented milestone in high-energy physics, the many institutes around the world involved in linear collider R&D united in a common effort to produce a global design for the ILC. In November 2004, the 1st International Linear Collider Workshop was held at KEK, Tsukuba, Japan. The workshop was attended by some 200 accelerator physicists from around the world, and paved the way for the 2nd ILC Workshop in August 2005, held at Snowmass, Colorado, USA, where the ILC Global Design Effort (GDE) was officially formed. The GDE membership reflects the global nature of the collaboration, with accelerator experts from all three regions (Americas, Asia and Europe). The first major goal of the GDE was to define the basic parameters and layout of the machine--the Baseline Configuration. This was achieved at the first GDE meeting held at INFN, Frascati, Italy in December 2005 with the creation of the Baseline Configuration Document (BCD). During the next 14 months, the BCD was used as the basis for the detailed design work and value estimate (as described in section 1.6) culminating in the completion of the second major milestone, the publication of the draft ILC Reference Design Report (RDR). The technical design and cost estimate for the ILC is based on two decades of world-wide Linear Collider R&D, beginning with the construction and operation of the SLAC Linear Collider (SLC). The SLC is acknowledged as a proof-of-principle machine for the linear collider concept. The ILC SCRF linac technology was pioneered by the TESLA collaboration*, culminating in

  9. ILC Reference Design Report: Accelerator Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Phinney, Nan; /SLAC

    2007-12-14

    The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radiofrequency (SCRF) accelerating cavities. The use of the SCRF technology was recommended by the International Technology Recommendation Panel (ITRP) in August 2004 [1], and shortly thereafter endorsed by the International Committee for Future Accelerators (ICFA). In an unprecedented milestone in high-energy physics, the many institutes around the world involved in linear collider R&D united in a common effort to produce a global design for the ILC. In November 2004, the 1st International Linear Collider Workshop was held at KEK, Tsukuba, Japan. The workshop was attended by some 200 accelerator physicists from around the world, and paved the way for the 2nd ILC Workshop in August 2005, held at Snowmass, Colorado, USA, where the ILC Global Design Effort (GDE) was officially formed. The GDE membership reflects the global nature of the collaboration, with accelerator experts from all three regions (Americas, Asia and Europe). The first major goal of the GDE was to define the basic parameters and layout of the machine--the Baseline Configuration. This was achieved at the first GDE meeting held at INFN, Frascati, Italy in December 2005 with the creation of the Baseline Configuration Document (BCD). During the next 14 months, the BCD was used as the basis for the detailed design work and value estimate (as described in section 1.6) culminating in the completion of the second major milestone, the publication of the draft ILC Reference Design Report (RDR). The technical design and cost estimate for the ILC is based on two decades of world-wide Linear Collider R&D, beginning with the construction and operation of the SLAC Linear Collider (SLC). The SLC is acknowledged as a proof-of-principle machine for the linear collider concept. The ILC SCRF linac technology was pioneered by the TESLA collaboration*, culminating in

  10. Code comparison for accelerator design and analysis

    International Nuclear Information System (INIS)

    This paper presents a comparison between results obtained from standard accelerator physics codes used for the design and analysis of sychrotrons and storage rings, with programs SYNCH, MAD, HARMON, PATRICIA, PATPET, BETA, DIMAD, MARYLIE and RACETRACK. In the analysis the authors have considered 5 (various size) lattices with large and small bend angles including AGS Booster (10 degrees bend) RHIC (2.24 degrees), SXLS, XLS (XUV ring with 45 degrees bend) and X-RAY rings. The differences in the integration methods used and the treatment of the fringe fields in these codes could lead to different results. The inclusion of nonlinear (e.g. dipole) terms may be necessary in these calculations specially for a small ring

  11. Code comparison for accelerator design and analysis

    International Nuclear Information System (INIS)

    We present a comparison between results obtained from standard accelerator physics codes used for the design and analysis of synchrotrons and storage rings, with programs SYNCH, MAD, HARMON, PATRICIA, PATPET, BETA, DIMAD, MARYLIE and RACE-TRACK. In our analysis we have considered 5 (various size) lattices with large and small angles including AGS Booster (10/degree/ bend), RHIC (2.24/degree/), SXLS, XLS (XUV ring with 45/degree/ bend) and X-RAY rings. The differences in the integration methods used and the treatment of the fringe fields in these codes could lead to different results. The inclusion of nonlinear (e.g., dipole) terms may be necessary in these calculations specially for a small ring. 12 refs., 6 figs., 10 tabs

  12. Design and fabrication of a miniaturization micro volume auto titrator coupled with electrochemical end-point detector for the determination of acidity of some fruit juice

    Directory of Open Access Journals (Sweden)

    Prinya Masawat

    2008-06-01

    Full Text Available A miniaturization micro volume auto titrator coupled with electrochemical end-point detector was designed and fabricated for the determination of acidity of some Thai citrus fruit juices collected in the northern area of Thailand. The method was based on on-line potentiometric titration of the acid contents with sodium hydroxide. Conditions such as volume of fruit juice sample, volume and concentration of potassium chloride used as supporting electrolyte and flow rate of titrant were optimized by using univariate optimization. A sample throughput of 83 samples h-1 at 0.28 mL/min was achieved with satisfactory results. The results obtained by the proposed method agreed with those obtained by using the standard classical titration method.

  13. Conception design of helium ion FFAG accelerator with induction accelerating cavity

    Institute of Scientific and Technical Information of China (English)

    LUO Huan-Li; XU Yu-Cun; WANG Xiang-Qi; XU Hong-Liang

    2013-01-01

    In the recent decades of particle accelerator R&D area,the fixed field alternating gradient (FFAG) accelerator has become a highlight for some advantages of its higher beam intensity and lower cost,although there are still some technical challenges.In this paper,the FFAG accelerator is adopted to accelerate a helium ion beam on the one hand for the study of helium embrittlement on fusion reactor envelope material and on the other hand for promoting the conception research and design of the FFAG accelerator and exploring the possibility of developing high power FFAG accelerators.The conventional period focusing unit of the helium ion FFAG accelerator and threedimensional model of the large aperture combinatorial magnet by OPERA-TOSCA are given.For low energy and low revolution frequency,induction acceleration is proposed to replace conventional radio frequency (RF) acceleration for the helium ion FFAG accelerator,which avoids the potential breakdown of the acceleration field caused by the wake field and improves the acceleration repetition frequency to gain higher beam intensity.The main parameters and three-dimensional model of induction cavity are given.Two special constraint waveforms are proposed to refrain from particle accelerating time slip (AT) caused by accelerating voltage drop of flat top and energy deviation.The particle longitudinal motion in two waveforms is simulated.

  14. Self-shielded electron linear accelerators designed for radiation technologies

    Science.gov (United States)

    Belugin, V. M.; Rozanov, N. E.; Pirozhenko, V. M.

    2009-09-01

    This paper describes self-shielded high-intensity electron linear accelerators designed for radiation technologies. The specific property of the accelerators is that they do not apply an external magnetic field; acceleration and focusing of electron beams are performed by radio-frequency fields in the accelerating structures. The main characteristics of the accelerators are high current and beam power, but also reliable operation and a long service life. To obtain these characteristics, a number of problems have been solved, including a particular optimization of the accelerator components and the application of a variety of specific means. The paper describes features of the electron beam dynamics, accelerating structure, and radio-frequency power supply. Several compact self-shielded accelerators for radiation sterilization and x-ray cargo inspection have been created. The introduced methods made it possible to obtain a high intensity of the electron beam and good performance of the accelerators.

  15. Design and status of the AGS booster accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Forsyth, E.B.; Lee, Y.Y.

    1987-01-01

    Comments are given on some areas of the design considered for the AGS Booster Accelerator, including lattice design, energy and repetition rate, injection, radio frequency system, and the vacuum system. The current status is then briefly described. (LEW)

  16. Design of an electromagnetic accelerator for turbulent hydrodynamic mix studies

    Energy Technology Data Exchange (ETDEWEB)

    Susoeff, A.R.; Hawke, R.S.; Morrison, J.J.; Dimonte, G.; Remington, B.A.

    1993-12-08

    An electromagnetic accelerator in the form of a linear electric motor (LEM) has been designed to achieve controlled acceleration profiles of a carriage containing hydrodynamically unstable fluids for the investigation of the development of turbulent mix. The Rayleigh- Taylor instability is investigated by accelerating two dissimilar density fluids using the LEM to achieve a wide variety of acceleration and deceleration profiles. The acceleration profiles are achieved by independent control of rail and augmentation currents. A variety of acceleration-time profiles are possible including: (1) constant, (2) impulsive and (3) shaped. The LEM and support structure are a robust design in order to withstand high loads with deflections and to mitigate operational vibration. Vibration of the carriage during acceleration could create artifacts in the data which would interfere with the intended study of the Rayleigh-Taylor instability. The design allows clear access for diagnostic techniques such as laser induced fluorescence radiography, shadowgraphs and particle imaging velocimetry. Electromagnetic modeling codes were used to optimize the rail and augmentation coil positions within the support structure framework. Results of contemporary studies for non-arcing sliding contact of solid armatures are used for the design of the driving armature and the dynamic electromagnetic braking system. A 0. 6MJ electrolytic capacitor bank is used for energy storage to drive the LEM. This report will discuss a LEM design which will accelerate masses of up to 3kg to a maximum of about 3000g{sub o}, where g{sub o} is accelerated due to gravity.

  17. Third order TRANSPORT with MAD (Methodical Accelerator Design) input

    Energy Technology Data Exchange (ETDEWEB)

    Carey, D.C.

    1988-09-20

    This paper describes computer-aided design codes for particle accelerators. Among the topics discussed are: input beam description; parameters and algebraic expressions; the physical elements; beam lines; operations; and third-order transfer matrix. (LSP)

  18. Accelerated Life Test Design for Tractor Powertrain Front Axle

    Directory of Open Access Journals (Sweden)

    Ismail Azianti

    2016-01-01

    Full Text Available Accelerated Life Test (ALT has been applied in the manufacturing for many years due to rapid changing technologies, more complex products, speedier product development, and more demanding customer requirements. These reasons have pushed the manufacturers to acquire reliability information faster. ALT allows reducing the time needed to show the reliability of the product. The purpose of this study is to design accelerated life testing which involved determination of normal test time, acceleration factor, acceleration test time, and finally experimental setup. This case study provides the basis for ALT designs for the tractor front axle based on customer usage and field failure analysis, which were conducted to estimate the current reliability, especially on the B10 life during the operational stage of the product. The accelerated life test conducted has guaranteed the B10 life of 4,000 hours with 90% confidence level for lesser time needed for testing to show the reliability of the front axle assembly.

  19. Design of a dedicated heavy ion accelerator for radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Gough, R.; Alonso, J.; Elioff, T.

    1983-03-01

    A new heavy-ion accelerator facility for radiotherapy is being designed at the Lawrence Berkeley Laboratory. Performance requirements have been established. Ions from helium to argon can be accelerated to a maximum energy of 800 MeV/nucleon with intensities in the range 10/sup 8/ to 10/sup 9/ particles per second. The accelerator subsystems consist of a linac injector, a synchrotron, and a beam-delivery system. Specifications have been developed for many of the technical components, and some details of the technical design are presented.

  20. Travelling wave accelerating structure design for TESLA positron injector linac

    CERN Document Server

    Jin, K; Zhou, F; Flöttmann, K

    2000-01-01

    A modified cup-like TW accelerating structure for TESLA Positron Pre-Accelerator (PPA) is designed by optimizing the structure geometry and by changing the iris thickness cell by cell in a section . This structure has high shunt-impedance and a large iris radius to meet with the requirements of high gradient and large transverse acceptance. The beam dynamics in the structure with the optimum solenoid focus field are studied. A satisfactory positron beam transmission and the beam performance at the PPA output have been obtained. In this paper the accelerating structure design is described in detail and the results are presented.

  1. The impact of acceleration on barrel/launch package design

    International Nuclear Information System (INIS)

    This paper discusses the impact of launch acceleration on the design of electromagnetic launcher barrels and on the design of associated launch packages. This is of particular interest because launch package size and mass directly affect the overall armament system size and mass. A common design approach is to use as the peak launch acceleration, the maximum acceleration which the projectile can be designed to withstand. While this approach will minimize barrel length, it may also yield an excessively large overall system size and mass, especially for the long, slender projectile configurations which are desired for high aero-thermal and terminal ballistics performance. An alternate design approach is described which balances the goals of reducing barrel length with reducing launch package mass. Results illustrate the benefits of this balanced design approach on overall armament system size and mass

  2. A Components Database Design and Implementation for Accelerators and Detectors.

    Science.gov (United States)

    Chan, A.; Meyer, S.

    1997-05-01

    Many accelerator and detector systems being fabricated for the PEP-II Accelerator and BaBar Detector needed configuration control and calibration measurements tracked for their components. Instead of building a database for each distinct system, a Components Database was designed and implemented that can encompass any type of component and any type of measurement. In this paper we describe this database design which is especially suited for the engineering and fabrication processes of the accelerator and detector environments where there are thousands of unique component types. We give examples of information stored in the Components Database, which includes accelerator configuration, calibration measurements, fabrication history, design specifications, inventory, etc. The World Wide Web interface is used to access the data, and templates are available for international collaborations to collect data off-line.

  3. Integrated design of superconducting accelerator magnets

    CERN Document Server

    Russenschuck, Stephan; Ramberger, S; Rodríguez-Mateos, F; Wolf, R

    1999-01-01

    This chapter introduces the main features of the ROXIE program which has been developed for the design of the superconducting magnets for the Large Hadron Collider (LHC) at CERN. The program combines numerical field calculation with a reduced vector-potential formulation, the application of vector-optimization methods, and the use of genetic as well as deterministic minimization algorithms. Together with the applied concept of features, the software is used as an approach towards integrated design of superconducting magnets. The main quadrupole magnet for the LHC, was chosen as an example for the integrated design process. (17 refs).

  4. Design of MEMS accelerometer based acceleration measurement system for automobiles

    Science.gov (United States)

    Venkatesh, K. Arun; Mathivanan, N.

    2012-10-01

    Design of an acceleration measurement system using a MEMS accelerometer to measure acceleration of automobiles in all the three axes is presented. Electronic stability control and anti-lock breaking systems in automobiles use the acceleration measurements to offer safety in driving. The system uses an ARM microcontroller to quantize the outputs of accelerometer and save the measurement data on a microSD card. A LabVIEW program has been developed to analyze the longitudinal acceleration measurement data and test the measurement system. Random noises generated and added with measurement data during measurement are filtered by a Kalman filter implemented in LabVIEW. Longitudinal velocity of the vehicle is computed from the measurement data and displayed on a graphical chart. Typical measurement of velocity of a vehicle at different accelerations and decelerations is presented.

  5. EDGOM – Game Design Accelerates Students’ Performance

    OpenAIRE

    Nur Hazwani Mohamad Roseli; Nurul Nadwan Aziz; Nurul Ulfa Abdul Aziz; Hasiah Mohamed Omar

    2011-01-01

    Educational computer game is one of the potential applications that is being researched to replace traditional method of teaching and learning.   It is believed that with the use of computer games in education, it is able to make learning process easier and student can grasp knowledge efficiently.   The way the game is designed is very crucial to ensure it can be adapted in the learning environment.  The purpose of this paper is to identify factors regarding game design that can enhance learn...

  6. EDGOM – Game Design Accelerates Students’ Performance

    Directory of Open Access Journals (Sweden)

    Nur Hazwani Mohamad Roseli

    2011-01-01

    Full Text Available Educational computer game is one of the potential applications that is being researched to replace traditional method of teaching and learning.   It is believed that with the use of computer games in education, it is able to make learning process easier and student can grasp knowledge efficiently.   The way the game is designed is very crucial to ensure it can be adapted in the learning environment.  The purpose of this paper is to identify factors regarding game design that can enhance learning process.  This paper also highlights problems that lead to the development of EDGOM and the way EDGOM will be developed.

  7. CEBAF [Continuous Electron Beam Accelerator Facility] design report

    International Nuclear Information System (INIS)

    This book describes the conceptual design of, and the planning for, the Continuous Electron Beam Accelerator Facility (CEBAF), which will be a high-intensity, continuous-wave electron linear accelerator (linac) for nuclear physics. Its principal scientific goal is to understand the quark structure, behavior, and clustering of individual nucleons in the nuclear medium, and simultaneously to understand the forces governing this behavior. The linac will consist of 1 GeV of accelerating structure, split into two antiparallel 0.5-GeV segments. The segments will be connected by a beam transport system to circulate the electron beams from one segment to the other for up to four complete passes of acceleration. The maximum beam energy will be 4 GeV at a design current of 200 microamperes. The accelerator complex will also include systems to extract three continuous beams from the linac and to deliver them to three experimental halls equipped with detectors and instrumentation for nuclear physics research. The accelerating structure will be kept superconducting within insulated cryostats filled with liquid helium produced at a central helium refrigerator and distributed to the cryostats via insulated transfer lines. An injector, instrumentation and controls for the accelerator, radio-frequency power systems, and several support facilities will also be provided. A cost estimate based on the Work Breakdown Structure has been completed. Assuming a five-year construction schedule starting early in FY 1987, the total estimated cost is $236 million (actual year dollars), including contingency

  8. Accelerator technical design report for high-intensity proton accelerator facility project, J-PARC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    This report presents the detail of the technical design of the accelerators for the High-Intensity Proton Accelerator Facility Project, J-PARC. The accelerator complex comprises a 400-MeV room-temperature linac (600-MeV superconducting linac), 3-GeV rapid-cycling synchrotron (RCS), and a 50-GeV synchrotron (MR). The 400-MeV beam is injected to the RCS, being accelerated to 3 GEV. The 1-MW beam thus produced is guided to the Materials Life Science Experimental Facility, with both the pulsed spallation neutron source and muon source. A part of the beam is transported to the MR, which provides the 0.75-MW beam to either the Nuclear and Fundamental Particle Experimental Facility or the Neutrino Production Target. On the other hand, the beam accelerated to 600 MeV by the superconducting linac is used for the Nuclear Waster Transmutation Experiment. In this way, this facility is unique, being multipurpose one, including many new inventions and Research and Development Results. This report is based upon the accomplishments made by the Accelerator Group and others of the Project Team, which is organized on the basis of the Agreement between JAERI and KEK on the Construction and Research and Development of the High-Intensity Proton Accelerator Facility. (author)

  9. Accelerators for Physics Experiments : From Diagnostics and Control to Design

    OpenAIRE

    Wildner, Elena

    2008-01-01

    This thesis develops techniques of control-methods, optimization, and diagnostics of accelerator equipment and the produced particle beams with emphasis on the Large Hadron Collider (LHC) project at CERN. From a solid knowledge of the characteristics of the manufactured accelerator equipment gained from in-depth measurements and analysis of measured data, a link to an enhanced equipment design can be made. These techniques will be demonstrated in applications related to the LHC magnet product...

  10. Post-accelerator LINAC design for the VECC RIB project

    Indian Academy of Sciences (India)

    Arup Bandyopadhyay

    2002-12-01

    Variable Energy Cyclotron Centre (VECC) is presently developing an ISOL post-acclerator type of RIB facility. The scheme utilises the existing = 130 room temperature variable energy cyclotron machine as the primary accelerator for the production of RIBs and radio frequency quadrupole (RFQ) and LINAC modules for the post-acceleration. The design aspects of these postaccelerator LINAC modules will be discussed in this paper.

  11. MREIT with SENSE acceleration using a dedicated RF coil design.

    Science.gov (United States)

    Muftuler, L Tugan; Chen, Gang; Hamamura, Mark J; Ha, Seung Hoon

    2009-09-01

    We have adapted a SENSE-accelerated imaging technique to magnetic resonance electrical impedance tomography (MREIT) in order to acquire data faster or improve spatial resolution without increasing the data acquisition time. We also designed and optimized an eight-channel, dedicated phased array coil for this application. The RF coil was designed as two planar arrays so that the open sides could accommodate the MREIT electrodes. A quasi-intrinsic decoupling scheme was used to minimize couplings between coil elements, and a restricted geometry optimization was applied to achieve high and uniform SNR within a given coil geometry and animal size. The impact of variability in the size of animals was also investigated in the optimization. This coil geometry provided approximately three times higher SNR at the center of a phantom when compared to a transmit/receive birdcage coil designed for MREIT of small animals. Therefore, the SNR was superior to the data acquired with volume coils even with three times SENSE acceleration. Both magnitude images and MREIT data were acquired from phantoms with and without SENSE acceleration, and the results were compared. The phantom studies demonstrated that conductivity maps can be reconstructed from MREIT data acquired with three times SENSE acceleration and that no discernible artifacts were observed when accelerated data acquisition was compared to non-accelerated data. PMID:19641236

  12. Design of Octupole Channel for Integrable Optics Test Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Antipov, Sergey [Chicago U.; Carlson, Kermit [Fermilab; Castellotti, Riccardo [Unlisted, IT; Valishev, Alexander [Fermilab; Wesseln, Steven [Fermilab

    2016-06-01

    We present the design of octupole channel for Integrable Optics Test Accelerator (IOTA). IOTA is a test accelerator at Fermilab, aimed to conduct research towards high-intensity machines. One of the goals of the project is to demonstrate high nonlinear betatron tune shifts while retaining large dynamic aperture in a realistic accelerator design. At the first stage the tune shift will be attained with a special channel of octupoles, which creates a variable octupole potential over a 1.8 m length. The channel consists of 18 identical air-cooled octupole magnets. The magnets feature a simple low-cost design, while meeting the requirements on maximum gradient - up to 1.4 kG/cm³, and field quality - strength of harmonics below 1%. Numerical simulations show that the channel is capable of producing a nonlinear tune shift of 0.08 without restriction of dynamic aperture of the ring.

  13. Reliability Approach for Machine Protection Design in Particle Accelerators

    CERN Document Server

    Apollonio, A; Mikulec, B; Puccio, B; Sanchez Alvarez, J L; Schmidt, R; Wagner, S

    2013-01-01

    Particle accelerators require Machine Protection Systems (MPS) to prevent beam-induced damage of equipment in case of failures. This becomes increasingly important for proton colliders with large energy stored in the beam such as LHC, for high power accelerators with a beam power of up to 10 MW, such as the European Spallation Source (ESS), and for linear colliders with high beam power and very small beam size. The reliability of Machine Protection Systems is crucial for safe machine operation; all possible sources of risk need to be taken into account in the early design stage. This paper presents a systematic approach to classify failures and to assess the associated risk, and discusses the impact of such considerations on the design of Machine Protection Systems. The application of this approach will be illustrated using the new design of the MPS for LINAC4, a linear accelerator under construction at CERN.

  14. RFQ design for the RAON accelerator's ISOL system

    Science.gov (United States)

    Choi, Bong Hyuk; Hong, In-Seok

    2015-10-01

    The heavy-ion accelerator RAON has the advantage of having both an in-flight (IF) and an isotope separator on-line (ISOL) system. Two radio frequency quadrupoles (RFQs) will be installed in the RAON: the main linear accelerator (LINAC) RFQ will be used to accelerate the two-charge state 238U for the IF system, while the post-accelerator RFQ will be used to accelerate low-current isotope beams from the ISOL system. In this paper, the post-accelerator RFQ design for the ISOL system is reported. A beam current of 1 pμA was used, and the input beam and the output beam energies were 5 keV/u and 400 keV/u, respectively. Moreover, the design was optimized by reducing the total length and power, adjusting the beam quality. To quantify the influence of thermal expansion on the frequency, we calculated the frequency difference according to deference between the vane's tip and the body's diameter.

  15. Design and progress of the AIRIX induction accelerator

    International Nuclear Information System (INIS)

    A new electron accelerator is now being studied and designed for Flash Radiography Application. It consists of a pulsed injector (4 MeV-3.5 kA - 60 ns) and an Induction Accelerator increasing the energy of the electrons up to 20 MeV. The authors briefly describe the Injector built by PSI and similar to the DARHT injector at LANL. They present studies and experimental tests carried out in order to design and build new induction cells and high voltage generators suitable for this application. Information is given on the PIVAIR milestone planned for a beforehand validation of the whole AIRIX machine

  16. Conceptual design of a commercial accelerator driven thorium reactor

    International Nuclear Information System (INIS)

    This paper describes the substantial work done in underpinning and developing the concept design for a commercial 600 MWe, accelerator driven, thorium fuelled, lead cooled, power producing, fast reactor. The Accelerator Driven Thorium Reactor (ADTR TM) has been derived from original work by Carlo Rubbia. Over the period 2007 to 2009 Aker Solutions commissioned this concept design work and, in close collaboration with Rubbia, developed the physics, engineering and business model. Much has been published about the Energy Amplifier concept and accelerator driven systems. This paper concentrates on the unique physics developed during the concept study of the ADTR TM power station and the progress made in engineering and design of the system. Particular attention is paid to where the concept design has moved significantly beyond published material. Description of challenges presented for the engineering and safety of a commercial system and how they will be addressed is included. This covers the defining system parameters, accelerator sizing, core and fuel design issues and, perhaps most importantly, reactivity control. The paper concludes that the work undertaken supports the technical viability of the ADTR TM power station. Several unique features of the reactor mean that it can be deployed in countries with aspirations to gain benefit from nuclear power and, at 600 MWe, it fits a size gap for less mature grid systems. It can provide a useful complement to Generation III, III+ and IV systems through its ability to consume actinides whilst at the same time providing useful power. (authors)

  17. Facilitating an accelerated experience-based co-design project.

    Science.gov (United States)

    Tollyfield, Ruth

    This article describes an accelerated experience-based co-design (AEBCD) quality improvement project that was undertaken in an adult critical care setting and the facilitation of that process. In doing so the aim is to encourage other clinical settings to engage with their patients, carers and staff alike and undertake their own quality improvement project. Patient, carer and staff experience and its place in the quality sphere is outlined and the importance of capturing patient, carer and staff feedback established. Experience-based co-design (EBCD) is described along with the recently tested accelerated version of the process. An overview of the project and outline of the organisational tasks and activities undertaken by the facilitator are given. The facilitation of the process and key outcomes are discussed and reflected on. Recommendations for future undertakings of the accelerated process are given and conclusions drawn. PMID:24526020

  18. Web-based guided insulin self-titration in patients with type 2 diabetes: the Di@log study. Design of a cluster randomised controlled trial [TC1316

    Directory of Open Access Journals (Sweden)

    Kostense Piet J

    2009-06-01

    Full Text Available Abstract Background Many patients with type 2 diabetes (T2DM are not able to reach the glycaemic target level of HbA1c Methods/Design T2DM patients (n = 248, aged 35–75 years, with an HbA1c ≥ 7.0%, eligible for treatment with insulin and able to use the internet will be selected from general practices in two different regions in the Netherlands. Cluster randomisation will be performed at the level of general practices. Patients in the intervention group will use a self-developed internet programme to assist them in self-titrating insulin. The control group will receive usual care. Primary outcome is the difference in change in HbA1c between intervention and control group. Secondary outcome measures are quality of life, treatment satisfaction, diabetes self-efficacy and frequency of hypoglycaemic episodes. Results will be analysed according to the intention-to-treat principle. Discussion An internet intervention supporting self-titration of insulin therapy in T2DM patients is an innovative patient-centred intervention. The programme provides guided self-monitoring and evaluation of health and self-care behaviours through tailored feedback on input of glucose values. This is expected to result in a better performance of self-titration of insulin and consequently in the improvement of glycaemic control. The patient will be enabled to 'discover and use his or her own ability to gain mastery over his/her diabetes' and therefore patient empowerment will increase. Based on the self-regulation theory of Leventhal, we hypothesize that additional benefits will be achieved in terms of increases in treatment satisfaction, quality of life and self-efficacy. Trial registration Dutch Trial Register TC1316.

  19. Open-label randomized trial of titrated disease management for patients with hypertension: Study design and baseline sample characteristics.

    Science.gov (United States)

    Jackson, George L; Weinberger, Morris; Kirshner, Miriam A; Stechuchak, Karen M; Melnyk, Stephanie D; Bosworth, Hayden B; Coffman, Cynthia J; Neelon, Brian; Van Houtven, Courtney; Gentry, Pamela W; Morris, Isis J; Rose, Cynthia M; Taylor, Jennifer P; May, Carrie L; Han, Byungjoo; Wainwright, Christi; Alkon, Aviel; Powell, Lesa; Edelman, David

    2016-09-01

    Despite the availability of efficacious treatments, only half of patients with hypertension achieve adequate blood pressure (BP) control. This paper describes the protocol and baseline subject characteristics of a 2-arm, 18-month randomized clinical trial of titrated disease management (TDM) for patients with pharmaceutically-treated hypertension for whom systolic blood pressure (SBP) is not controlled (≥140mmHg for non-diabetic or ≥130mmHg for diabetic patients). The trial is being conducted among patients of four clinic locations associated with a Veterans Affairs Medical Center. An intervention arm has a TDM strategy in which patients' hypertension control at baseline, 6, and 12months determines the resource intensity of disease management. Intensity levels include: a low-intensity strategy utilizing a licensed practical nurse to provide bi-monthly, non-tailored behavioral support calls to patients whose SBP comes under control; medium-intensity strategy utilizing a registered nurse to provide monthly tailored behavioral support telephone calls plus home BP monitoring; and high-intensity strategy utilizing a pharmacist to provide monthly tailored behavioral support telephone calls, home BP monitoring, and pharmacist-directed medication management. Control arm patients receive the low-intensity strategy regardless of BP control. The primary outcome is SBP. There are 385 randomized (192 intervention; 193 control) veterans that are predominately older (mean age 63.5years) men (92.5%). 61.8% are African American, and the mean baseline SBP for all subjects is 143.6mmHg. This trial will determine if a disease management program that is titrated by matching the intensity of resources to patients' BP control leads to superior outcomes compared to a low-intensity management strategy.

  20. Ground motion and its effects in accelerator design

    International Nuclear Information System (INIS)

    The effects of ground motion on accelerator design are discussed. The limitations on performance are discussed for various categories of motion. For example, effects due to ground settlement, tides, seismic disturbances and man-induced disturbances are included in this discussion. 42 figs., 7 tabs

  1. MREIT with SENSE acceleration using dedicated RF coil design

    OpenAIRE

    Muftuler, L Tugan; Chen, Gang; Hamamura, Mark J.; Ha, Seung Hoon

    2009-01-01

    We have adapted SENSE-accelerated imaging technique to Magnetic Resonance Electrical Impedance Tomography (MREIT) in order to acquire data faster or improve spatial resolution without increasing the data acquisition time. We also designed and optimized an 8-channel, dedicated phased array coil for this application. The RF coil was designed as two planar arrays so that the open sides could accommodate the MREIT electrodes. A quasi-intrinsic decoupling scheme was used to minimize couplings betw...

  2. Design of a 300 kV heavy ion accelerator

    International Nuclear Information System (INIS)

    The design of a 300 kV heavy ion accelerator is described. Two design aspects are emphasized: the telemetry system and the voltage control system. Telemetry with the high voltage terminal is achieved by transmitting digital light signals along fiber optics to a microprocessor. Voltage is controlled by a microprocessor and a hybrid analog/digital system. The relative merits of a microprocessor based system are discussed

  3. Beam optics and lattice design for particle accelerators

    OpenAIRE

    Holzer, Bernhard J.

    2013-01-01

    The goal of this manuscript is to give an introduction into the design of the magnet lattice and as a consequence into the transverse dynamics of the particles in a synchrotron or storage ring. Starting from the basic principles of how to design the geometry of the ring we will briefly review the transverse motion of the particles and apply this knowledge to study the layout and optimization of the principal elements, namely the lattice cells. The detailed arrangement of the accelerator magne...

  4. Accelerator technical design report for high-intensity proton accelerator facility project, J-PARC

    CERN Document Server

    2003-01-01

    This report presents the detail of the technical design of the accelerators for the High-Intensity Proton Accelerator Facility Project, J-PARC. The accelerator complex comprises a 400-MeV room-temperature linac (600-MeV superconducting linac), 3-GeV rapid-cycling synchrotron (RCS), and a 50-GeV synchrotron (MR). The 400-MeV beam is injected to the RCS, being accelerated to 3 GEV. The 1-MW beam thus produced is guided to the Materials Life Science Experimental Facility, with both the pulsed spallation neutron source and muon source. A part of the beam is transported to the MR, which provides the 0.75-MW beam to either the Nuclear and Fundamental Particle Experimental Facility or the Neutrino Production Target. On the other hand, the beam accelerated to 600 MeV by the superconducting linac is used for the Nuclear Waster Transmutation Experiment. In this way, this facility is unique, being multipurpose one, including many new inventions and Research and Development Results. This report is based upon the accompli...

  5. Accelerator-driven subcritical facility:Conceptual design development

    Energy Technology Data Exchange (ETDEWEB)

    Gohar, Yousry [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States)]. E-mail: gohar@anl.gov; Bolshinsky, Igor [Idaho National Laboratory, P.O. Box 2528, Idaho Falls, ID 83403 (United States); Naberezhnev, Dmitry [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Duo, Jose [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Pennsylvania State University, University Park, PA 16802 (United States); Belch, Henry [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Bailey, James [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States)

    2006-06-23

    A conceptual design development of an accelerator-driven subcritical facility has been carried out in the preparation of a joint activity with Kharkov Institute of Physics and Technology of Ukraine. The main functions of the facility are the medical isotope production and the support of the Ukraine nuclear industry. An electron accelerator is considered to drive the subcritical assembly. The neutron source intensity and spectrum have been studied. The energy deposition, spatial neutron generation, neutron utilization fraction, and target dimensions have been quantified to define the main target performance parameters, and to select the target material and beam parameters. Different target conceptual designs have been developed based the engineering requirements including heat transfer, thermal hydraulics, structure, and material issues. The subcritical assembly is designed to obtain the highest possible neutron flux level with a K {sub eff} of 0.98. Different fuel materials, uranium enrichments, and reflector materials are considered in the design process. The possibility of using low enrichment uranium without penalizing the facility performance is carefully evaluated. The mechanical design of the facility has been developed to maximize its utility and minimize the time for replacing the target and the fuel assemblies. Safety, reliability, and environmental considerations are included in the facility conceptual design. The facility is configured to accommodate future design improvements, upgrades, and new missions. In addition, it has large design margins to accommodate different operating conditions and parameters. In this paper, the conceptual design and the design analyses of the facility will be presented.

  6. A preliminary design of the collinear dielectric wakefield accelerator

    Science.gov (United States)

    Zholents, A.; Gai, W.; Doran, S.; Lindberg, R.; Power, J. G.; Strelnikov, N.; Sun, Y.; Trakhtenberg, E.; Vasserman, I.; Jing, C.; Kanareykin, A.; Li, Y.; Gao, Q.; Shchegolkov, D. Y.; Simakov, E. I.

    2016-09-01

    A preliminary design of the multi-meter long collinear dielectric wakefield accelerator that achieves a highly efficient transfer of the drive bunch energy to the wakefields and to the witness bunch is considered. It is made from ~0.5 m long accelerator modules containing a vacuum chamber with dielectric-lined walls, a quadrupole wiggler, an rf coupler, and BPM assembly. The single bunch breakup instability is a major limiting factor for accelerator efficiency, and the BNS damping is applied to obtain the stable multi-meter long propagation of a drive bunch. Numerical simulations using a 6D particle tracking computer code are performed and tolerances to various errors are defined.

  7. Design and construction status of the AGS Booster accelerator

    International Nuclear Information System (INIS)

    To meet the requirements of new experiments in high energy physics and nuclear physics, a fast cycling Booster accelerator was proposed to fulfill the following three technical objectives: The AGS Booster has three objectives. They are to increase the space charge limit of the AGS, to incrase the intensity of the polarized proton beam by accumulating many linac pulses (since the intensity is limited by the polarized ion source), and to re-accelerate heavy ions from the BNL Tandem Van de Graaff before injection iinto the AGS. The machine is capable of accelerating protons at 7.5 Hertz from 200 MeV to 1.5 GeV or to lower final energies at faster repetition rates. The machine will also be able to accelerate heavy ions from as low as 1 MeV/nucleon to a magnetic rigidity as high as 17.6 Tesla-meters with a one second repetition rate. As an accumulator for polarized protons, the Booster should be able to store the protons at 200 MeV for several seconds. We will report primarily those design and construction issues related to high intensity proton acceleration of the Booster. 4 refs., 6 figs., 4 tabs

  8. Design and development of R.F. LINAC accelerator components

    International Nuclear Information System (INIS)

    Full text: Radio frequency linear accelerator, a high power electron LINAC technology, is being developed at BARC. These accelerators are considered to be the most compact and effective for a given power capacity. Important application areas of this LINAC include medical sterilization, food preservation, pollution control, semiconductor industries, radiation therapy and material science. Center for Design and Manufacture (CDM), BARC has been entrusted with the design, development and manufacturing of various mechanical components of the accelerator. Most critical and precision components out of them are Diagnostic chamber, Faraday cup, Drift tube and R.F. cavities. This paper deals with the design aspects in respect of Ultra high vacuum compatibility and the mechanism of operation. Also this paper discusses the state-of-art technology for machining of intricate contour using specially designed poly crystalline diamond tool and the inspection methodology developed to minimize the measurement errors on the machined contour. Silver brazing technique employed to join the LINAC cavities is also described in detail

  9. Beam dynamics design for uranium drift tube linear accelerator

    Science.gov (United States)

    Dou, Wei-Ping; He, Yuan; Lu, Yuan-Rong

    2014-07-01

    KONUS beam dynamics design of uranium DTL with LORASR code is presented. The 238U34+ beam, whose current is 5.0 emA, is accelerated from injection energy of 0.35 MeV/u to output energy of 1.30 MeV/u by IH-DTL operated at 81.25 MHz in HIAF project at IMP of CAS. It achieves a transmission efficiency of 94.95% with a cavity length of 267.8 cm. The optimization aims are the reduction of emittance growth, beam loss and project costs. Because of the requirements of CW mode operation, the designed average acceleration gradient is about 2.48 MV/m. The maximum axial field is 10.2 MV/m, meanwhile the Kilpatrick breakdown field is 10.56 MV/m at 81.25 MHz.

  10. New developments in design and applications for Pelletron accelerators

    Indian Academy of Sciences (India)

    Greg Norton

    2002-11-01

    Most of the developments over the last several years related to Pelletron accelerator are in the field of accelerator mass spectrometry (AMS) and other low beam current applications with the exception of a very high DC electron recirculation Pelletron. High precision AMS systems based on tandem Pelletrons from 500 kV to 5 MV terminal potential are now in use for routine high precision AMS measurements. Their performance will be reported. In addition, there has been significant advancement in the design of the multi-cathode SNICS source for the use of both gas and solid samples within a single source. The latest performance of these sources will be discussed. New diagnostics is being developed for very low beam currents. The latest design of the low current beam profile monitor (LCBPM) will also be presented.

  11. Workshop on Accelerator Magnet Superconductors, Design and Optimization

    CERN Document Server

    WAMSDO Workshop

    2009-01-01

    This report contains the proceedings of the CARE-HHH-AMT Workshop on Accelerator Magnet Superconductors, Design and Optimization (WAMSDO) held at CERN from 19 to 23 May 2008. The needs in terms of superconducting magnets for the accelerator projects were discussed, mainly for the LHC interaction regions and injector upgrades, and for the GSI FAIR complex. The first part of the workshop focused on the development of superconductor and cables, i.e., low-loss Nb-Ti cables, Nb3Sn and high-temperature superconductors. An industry session summarized the actual plans and status of the activities in the main European industries. Then, a worldwide status of the high field magnets programme was presented. A special session was devoted to fast cycled magnets, including FAIR facilities and LHC injector upgrades. A final session focused on the optimization methods and numerical tools for magnet design.

  12. Design and Construction of the Linac4 Accelerating Structures

    CERN Document Server

    Gerigk, F; Dallocchio, A; Favre, G; Vretenar, M; Wegner, R; Tirado, P Ugena; Rossi, C; Riffaud, B; Ramberger, S; Polini, M; Gentini, L; Geisser, JM; Giguet, JM; Mathot, S; Naumenko, M; Kendjebulatov, E; Tribendis, A; Kryuchkov, Ya

    2013-01-01

    The Linac4 project at CERN is at an advanced state of construction. Prototypes and/or operational modules of the different types of accelerating structures (RFQ, buncher, DTL, CCDTL, and PIMS) have been built and are presently tested. This paper gives the status of the cavity production and reviews the RF and mechanical design of the various structure types. Furthermore the production experience and the first test results shall be presented.

  13. Bayesian optimal design of step stress accelerated degradation testing

    Institute of Scientific and Technical Information of China (English)

    Xiaoyang Li; Mohammad Rezvanizaniani; Zhengzheng Ge; Mohamed Abuali; Jay Lee

    2015-01-01

    This study presents a Bayesian methodology for de-signing step stress accelerated degradation testing (SSADT) and its application to batteries. First, the simulation-based Bayesian de-sign framework for SSADT is presented. Then, by considering his-torical data, specific optimal objectives oriented Kul back–Leibler (KL) divergence is established. A numerical example is discussed to il ustrate the design approach. It is assumed that the degrada-tion model (or process) fol ows a drift Brownian motion;the accele-ration model fol ows Arrhenius equation; and the corresponding parameters fol ow normal and Gamma prior distributions. Using the Markov Chain Monte Carlo (MCMC) method and WinBUGS software, the comparison shows that KL divergence is better than quadratic loss for optimal criteria. Further, the effect of simulation outliers on the optimization plan is analyzed and the preferred sur-face fitting algorithm is chosen. At the end of the paper, a NASA lithium-ion battery dataset is used as historical information and the KL divergence oriented Bayesian design is compared with maxi-mum likelihood theory oriented local y optimal design. The results show that the proposed method can provide a much better testing plan for this engineering application.

  14. Design of a Microwave Assisted Discharge Inductive Plasma Accelerator

    Science.gov (United States)

    Hallock, Ashley K.; Polzin, Kurt A.

    2010-01-01

    The design and construction of a thruster that employs electrodeless plasma preionization and pulsed inductive acceleration is described. Preionization is achieved through an electron cyclotron resonance discharge that produces a weakly-ionized plasma at the face of a conical theta pinch-shaped inductive coil. The presence of the preionized plasma allows for current sheet formation at lower discharge voltages than those employed in other pulsed inductive accelerators that do not employ preionization. The location of the electron cyclotron resonance discharge is controlled through the design of the applied magnetic field in the thruster. Finite element analysis shows that there is an arrangement of permanent magnets that yields a small volume of resonant magnetic field at the coil face. Preionization in the resonant zone leads to current sheet formation at the coil face, which minimizes the initial inductance of the pulse circuit and maximizes the potential electrical efficiency of the accelerator. A magnet assembly was constructed around an inductive coil to provide structural support to the selected arrangement of neodymium magnets. Measured values of the resulting magnetic field compare favorably with the finite element model.

  15. Electron accelerator shielding design of KIPT neutron source facility

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Zhao Peng; Gohar, Yousry [Argonne National Laboratory, Argonne (United States)

    2016-06-15

    The Argonne National Laboratory of the United States and the Kharkov Institute of Physics and Technology of the Ukraine have been collaborating on the design, development and construction of a neutron source facility at Kharkov Institute of Physics and Technology utilizing an electron-accelerator-driven subcritical assembly. The electron beam power is 100 kW using 100-MeV electrons. The facility was designed to perform basic and applied nuclear research, produce medical isotopes, and train nuclear specialists. The biological shield of the accelerator building was designed to reduce the biological dose to less than 5.0e-03 mSv/h during operation. The main source of the biological dose for the accelerator building is the photons and neutrons generated from different interactions of leaked electrons from the electron gun and the accelerator sections with the surrounding components and materials. The Monte Carlo N-particle extended code (MCNPX) was used for the shielding calculations because of its capability to perform electron-, photon-, and neutron-coupled transport simulations. The photon dose was tallied using the MCNPX calculation, starting with the leaked electrons. However, it is difficult to accurately tally the neutron dose directly from the leaked electrons. The neutron yield per electron from the interactions with the surrounding components is very small, ∼0.01 neutron for 100-MeV electron and even smaller for lower-energy electrons. This causes difficulties for the Monte Carlo analyses and consumes tremendous computation resources for tallying the neutron dose outside the shield boundary with an acceptable accuracy. To avoid these difficulties, the SOURCE and TALLYX user subroutines of MCNPX were utilized for this study. The generated neutrons were banked, together with all related parameters, for a subsequent MCNPX calculation to obtain the neutron dose. The weight windows variance reduction technique was also utilized for both neutron and photon dose

  16. Challenges in the design of linear accelerator tunnels and services

    CERN Document Server

    Osborne, John

    2008-01-01

    Studies are well underway for the next generation of linear accelerators. The International Linear Collider (ILC) is working towards a maximum collision energy of 1 TeV and the Compact Linear Collider (CLIC) even higher at 3 TeV. Although the accelerating technologies are very different, many similarities can be found between the two projects from a civil engineering and technical services point of view. Both projects would require a site of approximately 50 km in length with stable geological conditions. CERN has been selected as one of the sample sites for the preliminary studies. The aim of this paper is to present the key challenges in the design of civil engineering and technical services such as cooling, ventilation and electricity that need to be overcome to realise such large scale projects in the future.

  17. A traveling-wave forward coupler design for a new accelerating mode in a silicon woodpile accelerator

    International Nuclear Information System (INIS)

    Silicon woodpile photonic crystals provide a base structure that can be used to build a three-dimensional dielectric waveguide system for high-gradient laser driven acceleration. A new woodpile waveguide design that hosts a phase synchronous, centrally confined accelerating mode is proposed. Comparing with previously discovered silicon woodpile accelerating modes, this mode shows advantages in terms of better electron beam loading and higher achievable acceleration gradient. Several traveling-wave coupler design schemes developed for multi-cell RF cavity accelerators are adapted to the woodpile power coupler design for this new accelerating mode. Design of a forward coupled, highly efficient silicon woodpile accelerator is achieved. Simulation shows high efficiency of over 75% of the drive laser power coupled to this fundamental accelerating mode, with less than 15% backward wave scattering. The estimated acceleration gradient, when the coupler structure is driven at the damage threshold fluence of silicon at its operating 1.506 μm wavelength, can reach 185 MV/m. Lastly, a 17-layer woodpile waveguide structure was successfully fabricated, and the measured bandgap is in excellent agreement with simulation

  18. LEGO - A Class Library for Accelerator Design and Simulation

    International Nuclear Information System (INIS)

    An object-oriented class library of accelerator design and simulation is designed and implemented in a simple and modular fashion. All physics of single-particle dynamics is implemented based on the Hamiltonian in the local frame of the component. Symplectic integrators are used to approximate the integration of the Hamiltonian. A differential algebra class is introduced to extract a Taylor map up to arbitrary order. Analysis of optics is done in the same way both for the linear and non-linear cases. Recently, Monte Carlo simulation of synchrotron radiation has been added into the library. The code is used to design and simulate the lattices of the PEP-II and SPEAR3. And it is also used for the commissioning of the PEP-II. Some examples of how to use the library will be given

  19. Engineering Design of a Multipurpose X-band Accelerating Structure

    CERN Document Server

    Gudkov, Dmitry; Samoshkin, Alexander; Zennaro, Riccardo; Dehler, Micha; Raguin, Jean-Yves

    2010-01-01

    Both FEL projects, SwissFEL and Fermi-Elettra each require an X-band RF accelerating structure for optimal bunch compression at the respective injectors. As the CLIC project is pursuing a program for producing and testing the X-band high-gradient RF structures, a collaboration between PSI, Elettra and CERN has been established to build a multipurpose X-band accelerating structure. This paper focuses on its engineering design, which is based on the disked cells jointed together by diffusion bonding. Vacuum brazing and laser beam welding is used for auxiliary components. The accelerating structure consists of two coupler subassemblies, 73 disks and includes a wakefield monitor and diagnostic waveguides. The engineering study includes the external cooling system, consisting of two parallel cooling circuits and an RF tuning system, which allows phase advance tuning of the cell by deforming the outer wall. The engineering solution for the installation and sealing of the wake field monitor feed-through devices that...

  20. Accelerating Battery Design Using Computer-Aided Engineering Tools: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A.; Heon, G. H.; Smith, K.

    2011-01-01

    Computer-aided engineering (CAE) is a proven pathway, especially in the automotive industry, to improve performance by resolving the relevant physics in complex systems, shortening the product development design cycle, thus reducing cost, and providing an efficient way to evaluate parameters for robust designs. Academic models include the relevant physics details, but neglect engineering complexities. Industry models include the relevant macroscopic geometry and system conditions, but simplify the fundamental physics too much. Most of the CAE battery tools for in-house use are custom model codes and require expert users. There is a need to make these battery modeling and design tools more accessible to end users such as battery developers, pack integrators, and vehicle makers. Developing integrated and physics-based CAE battery tools can reduce the design, build, test, break, re-design, re-build, and re-test cycle and help lower costs. NREL has been involved in developing various models to predict the thermal and electrochemical performance of large-format cells and has used in commercial three-dimensional finite-element analysis and computational fluid dynamics to study battery pack thermal issues. These NREL cell and pack design tools can be integrated to help support the automotive industry and to accelerate battery design.

  1. Design & simulation of a 800 kV dynamitron accelerator by CST studio

    Directory of Open Access Journals (Sweden)

    A M Aghayan

    2015-09-01

    Full Text Available Nowadays, middle energy electrostatic accelerators in industries are widely used due to their high efficiency and low cost compared with other types of accelerators. In this paper, the importance and applications of electrostatic accelerators with 800 keV energy are studied. Design and simulation of capacitive coupling of a dynamitron accelerator is proposed. Furthermore, accelerating tube are designed and simulated by means of CST Suit Studio

  2. Design and construction of the first Iranian powerful industrial electron accelerator

    Directory of Open Access Journals (Sweden)

    AM Poursaleh

    2015-09-01

    Full Text Available In This paper we will introduce the process of design and manufacturing an electron accelerator with 10MeV energy and 100kW power as the first Iranian powerful industrial electron accelerator. This accelerator designed based on modeling of one of the most powerful industrial accelerator called Rhodotron. But the design of the accelerator in a way that can be localize by relying on domestic industries. So although it looks like a Rhodotron accelerator structure but has some different in design and manufacture of components, the results are satisfactory

  3. Design, testing and modifications of the Pelletron accelerator and future uses

    International Nuclear Information System (INIS)

    Solutions to various problems in the design of high voltage generator and acceleration units of the Pelletron electron accelerator designed and constructed at ININ are presented. Information on the design of the control system of the electron beams, activities proposed for utilization of sulfur hexafluoride as an accelerator isolating gas as well as some future uses of the Pelletron. (Author). 7 refs, 3 figs

  4. Beam optics and lattice design for particle accelerators

    CERN Document Server

    Holzer, Bernhard J

    2013-01-01

    The goal of this manuscript is to give an introduction into the design of the magnet lattice and as a consequence into the transverse dynamics of the particles in a synchrotron or storage ring. Starting from the basic principles of how to design the geometry of the ring we will briefly review the transverse motion of the particles and apply this knowledge to study the layout and optimization of the principal elements, namely the lattice cells. The detailed arrangement of the accelerator magnets within the cells is explained and will be used to calculate well defined and predictable beam parameters. The more specific treatment of low beta insertions is included as well as the concept of dispersion suppressors that are an indispensable part of modern collider rings.

  5. Proceedings of the Advanced Hadron Facility accelerator design workshop

    International Nuclear Information System (INIS)

    The International Workshop on Hadron Facility Technology was held February 22-27, 1988, at the Study Center at Los Alamos National Laboratory. The program included papers on facility plans, beam dynamics, and accelerator hardware. The parallel sessions were particularly lively with discussions of all facets of kaon factory design. The workshop provided an opportunity for communication among the staff involved in hadron facility planning from all the study groups presently active. The recommendations of the workshop include: the need to use h=1 RF in the compressor ring; the need to minimize foil hits in painting schemes for all rings; the need to consider single Coulomb scattering in injection beam los calculations; the need to study the effect of field inhomogeneity in the magnets on slow extraction for the 2.2 Tesla main ring of AHF; and agreement in principle with the design proposed for a joint Los Alamos/TRIUMF prototype main ring RF cavity

  6. Machine Learning Strategy for Accelerated Design of Polymer Dielectrics

    Science.gov (United States)

    Mannodi-Kanakkithodi, Arun; Pilania, Ghanshyam; Huan, Tran Doan; Lookman, Turab; Ramprasad, Rampi

    2016-02-01

    The ability to efficiently design new and advanced dielectric polymers is hampered by the lack of sufficient, reliable data on wide polymer chemical spaces, and the difficulty of generating such data given time and computational/experimental constraints. Here, we address the issue of accelerating polymer dielectrics design by extracting learning models from data generated by accurate state-of-the-art first principles computations for polymers occupying an important part of the chemical subspace. The polymers are ‘fingerprinted’ as simple, easily attainable numerical representations, which are mapped to the properties of interest using a machine learning algorithm to develop an on-demand property prediction model. Further, a genetic algorithm is utilised to optimise polymer constituent blocks in an evolutionary manner, thus directly leading to the design of polymers with given target properties. While this philosophy of learning to make instant predictions and design is demonstrated here for the example of polymer dielectrics, it is equally applicable to other classes of materials as well.

  7. ''Titration'' polymerization of monovinylacetylene

    NARCIS (Netherlands)

    Mavinkurve, A; Visser, S; vandenBroek, W; Pennings, AJ

    1996-01-01

    A polymer consisting of a saturated carbon backbone with pendent acetylenic groups was prepared from monovinylacetylene. A titration was performed between the monomer and tertiary butyllithium, its lithiating agent. The charge transfer complex formed between the solvent THF and the tertiary butyllit

  8. Filtrates & Residues: Olfactory Titration.

    Science.gov (United States)

    Wood, John T.; Eddy, Roberta M.

    1996-01-01

    Presents an experiment that uses a unique acid-base indicator--the odor of raw onion--to indicate the end point of the titration of sodium hydroxide with hydrochloric acid. Allows the student to detect the completion of the neutralization reaction by olfaction rather than sight. (JRH)

  9. Accelerator

    International Nuclear Information System (INIS)

    The invention claims equipment for stabilizing the position of the front covers of the accelerator chamber in cyclic accelerators which significantly increases accelerator reliability. For stabilizing, it uses hydraulic cushions placed between the electromagnet pole pieces and the front chamber covers. The top and the bottom cushions are hydraulically connected. The cushions are disconnected and removed from the hydraulic line using valves. (J.P.)

  10. The physics design of accelerator-driven transmutation systems

    International Nuclear Information System (INIS)

    Nuclear systems under study in the Los Alamos Accelerator-Driven Transmutation Technology program (ADTT) will allow the destruction of nuclear spent fuel and weapons-return plutonium, as well as the production of nuclear energy from the thorium cycle, without a long-lived radioactive waste stream. The subcritical systems proposed represent a radical departure from traditional nuclear concepts (reactors), yet the actual implementation of ADTT systems is based on modest extrapolations of existing technology. These systems strive to keep the best that the nuclear technology has developed over the years, within a sensible conservative design envelope and eventually manage to offer a safer, less expensive and more environmentally sound approach to nuclear power

  11. Design of Accelerator Online Simulator Server Using Structured Data

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Guobao; /Brookhaven; Chu, Chungming; /SLAC; Wu, Juhao; /SLAC; Kraimer, Martin; /Argonne

    2012-07-06

    Model based control plays an important role for a modern accelerator during beam commissioning, beam study, and even daily operation. With a realistic model, beam behaviour can be predicted and therefore effectively controlled. The approach used by most current high level application environments is to use a built-in simulation engine and feed a realistic model into that simulation engine. Instead of this traditional monolithic structure, a new approach using a client-server architecture is under development. An on-line simulator server is accessed via network accessible structured data. With this approach, a user can easily access multiple simulation codes. This paper describes the design, implementation, and current status of PVData, which defines the structured data, and PVAccess, which provides network access to the structured data.

  12. Conceptual design of industrial free electron laser using superconducting accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Saldin, E.L.; Schneidmiller, E.A.; Ulyanov, Yu.N. [Automatic Systems Corporation, Samara (Russian Federation)] [and others

    1995-12-31

    Paper presents conceptual design of free electron laser (FEL) complex for industrial applications. The FEL complex consists of three. FEL oscillators with the optical output spanning the infrared (IR) and ultraviolet (UV) wave-lengths ({lambda} = 0.3...20 {mu}m) and with the average output power 10 - 20 kW. The driving beam for the FELs is produced by a superconducting accelerator. The electron beam is transported to the FELs via three beam lines (125 MeV and 2 x 250 MeV). Peculiar feature of the proposed complex is a high efficiency of the. FEL oscillators, up to 20 %. This becomes possible due to the use of quasi-continuous electron beam and the use of the time-dependent undulator tapering.

  13. Computer control of large accelerators design concepts and methods

    International Nuclear Information System (INIS)

    Unlike most of the specialities treated in this volume, control system design is still an art, not a science. These lectures are an attempt to produce a primer for prospective practitioners of this art. A large modern accelerator requires a comprehensive control system for commissioning, machine studies and day-to-day operation. Faced with the requirement to design a control system for such a machine, the control system architect has a bewildering array of technical devices and techniques at his disposal, and it is our aim in the following chapters to lead him through the characteristics of the problems he will have to face and the practical alternatives available for solving them. We emphasize good system architecture using commercially available hardware and software components, but in addition we discuss the actual control strategies which are to be implemented since it is at the point of deciding what facilities shall be available that the complexity of the control system and its cost are implicitly decided. 19 references

  14. Nuclear design aspect of the Korean high intensity proton accelerator project

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jonghwa; Song, Tae-Yung [Korea Atomic Energy Research Inst., Yusong, Taejon (Korea, Republic of)

    1998-11-01

    A plan to construct a high current proton accelerator has been proposed by KAERI. We are presenting the required nuclear design to support the project as well as a brief overview of the proposed proton accelerator. The target and core design is highlighted to show feasibility of incineration of minor actinides from the spent fuel of light water reactors. Radiation shielding and activation analyses are also important for the design and the license of the accelerator. (author)

  15. Advanced Beamline Design for Fermilab's Advanced Superconducting Test Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, Christopher [Northern Illinois Univ., DeKalb, IL (United States)

    2014-01-01

    The Advanced Superconducting Test Accelerator (ASTA) at Fermilab is a new electron accelerator currently in the commissioning stage. In addition to testing superconducting accelerating cavities for future accelerators, it is foreseen to support a variety of Advanced Accelerator R&D (AARD) experiments. Producing the required electron bunches with the expected flexibility is challenging. The goal of this dissertation is to explore via numerical simulations new accelerator beamlines that can enable the advanced manipulation of electron bunches. The work especially includes the design of a low-energy bunch compressor and a study of transverse-to-longitudinal phase space exchangers.

  16. Electrostatic design and beam transport for a folded tandem electrostatic quadrupole accelerator facility for accelerator-based boron neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Thatar Vento, V., E-mail: Vladimir.ThatarVento@gmail.com [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina); Bergueiro, J.; Cartelli, D. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina); Valda, A.A. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. Irigoyen 3100 (1650), San Martin, Buenos Aires (Argentina); Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. Irigoyen 3100 (1650), San Martin, Buenos Aires (Argentina)

    2011-12-15

    Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), we discuss here the electrostatic design of the machine, including the accelerator tubes with electrostatic quadrupoles and the simulations for the transport and acceleration of a high intensity beam.

  17. Design of spheromak injector using conical accelerator for large helical device

    Energy Technology Data Exchange (ETDEWEB)

    Miyazawa, J.; Yamada, H.; Yasui, K.; Kato, S. [National Inst. for Fusion Science, Toki, Gifu (Japan); Fukumoto, N.; Nagata, M.; Uyama, T. [Himeji Inst. of Tech., Hyogo (Japan)

    1999-11-01

    Optimization of CT injector for LHD has been carried out and conical electrode for adiabatic CT compression is adopted in the design. Point-model of CT acceleration in a co-axial electrode is solved to optimize the electrode geometry and the power supplies. Large acceleration efficiency of 34% is to be obtained with 3.2 m long conical accelerator and 40 kV - 42 kJ power supply. The operation scenario of a CT injector named SPICA mk. I (SPheromak Injector using Conical Accelerator) consisting of 0.8 m conical accelerator is discussed based on this design. (author)

  18. Design Considerations for Plasma Accelerators Driven by Lasers or Particle Beams

    OpenAIRE

    Schroeder, C. B.

    2011-01-01

    Plasma accelerators may be driven by the ponderomotive force of an intense laser or the space-charge force of a charged particle beam. The implications for accelerator design and the different physical mechanisms of laser-driven and beam-driven plasma acceleration are discussed. Driver propagation is examined, as well as the effects of the excited plasma wave phase velocity. The driver coupling to subsequent plasma accelerator stages for high-energy physics applications is addressed.

  19. 自动电位滴定仪测定铁矿石中全铁量的自动化程序设计%Program designing for determination of total iron content in iron ore by automatic potentiometric titrator

    Institute of Scientific and Technical Information of China (English)

    马德起; 武素茹; 臧世阳

    2012-01-01

    本文采用微波消解—自动电位滴定法测定铁矿石全铁量.重点研究自动电位滴定仪编写空白的滴定程序编写的方式对结果的影响、设计滴定程序,以经典的手工滴定法作对比,结果相似,达到滴定过程的自动化.结果表明:本法适用于铁矿石中全铁量的检测,测定范围为40%~70%,相对标准偏差小于2%.%A method based on Time Slice Model (TSM) is proposed for batch processes heat exchanger network synthesis by taking place. Total iron content in iron ore was determined by automatic potentiometric titrator and the sample was digested by microwave. The program designing for blank was discussed which effect on the results, and also the program designing for total titration, and then the results conformed to the manual titration method. The method applies to determination of total iron content in iron ore, the inspection range was 40%~70%, RSD

  20. IFMIF accelerator facility RAMI analyses in the engineering design phase

    OpenAIRE

    Bargalló Font, Enric

    2014-01-01

    The planned International Fusion Materials Irradiation Facility (IFMIF) has the mission to test and qualify materials for future fusion reactors. IFMIF will employ the deuteron-lithium stripping reaction to irradiate the test samples with a high-energy neutron flux. IFMIF will consist mainly of two linear deuteron accelerators, a liquid lithium loop and a test cell. Accelerated deuterons will collide with the lithium producing a high-energy neutron flux that will irradiate the material sample...

  1. On the design and testing of solid armatures for rail accelerator applications

    Energy Technology Data Exchange (ETDEWEB)

    Karthaus, W.; de Zeeuw, W.A.; Kolkert, W.J. (TNO PML-Pulse Physics (NL))

    1991-01-01

    Two different armature designs, for rail accelerator applications have been studied during electromagnetic launch experiments. The designs investigated are an aluminium multi-finger monoblock and a copper fiber brush armature. The experimental set-up used and the results obtained together with an electro-thermal model that describes the armature interface behavior during the acceleration process itself are presented in this paper.

  2. New linear accelerator (Linac) design based on C-band accelerating structures for SXFEL facility

    Institute of Scientific and Technical Information of China (English)

    ZHANG Meng; GU Qiang

    2011-01-01

    A C-band accelerator structure is one promising technique for a compact XFEL facility.It is also attractive in beam dynamics in maintaining a high quality electron beam,which is an important factor in the performance of a free electron laser.In this paper,a comparison between traditional S-band and C-band accelerating structures is made based on the linac configuration of a Shanghai Soft X-ray Free Electron Laser (SXFEL) facility.Throughout the comprehensive simulation,we conclude that the C-band structure is much more competitive.

  3. Instructional Design for Accelerated Macrocognitive Expertise in the Baseball Workplace.

    Science.gov (United States)

    Fadde, Peter J

    2016-01-01

    The goal of accelerating expertise can leave researchers and trainers in human factors, naturalistic decision making, sport science, and expertise studies concerned about seemingly insufficient application of expert performance theories, findings and methods for training macrocognitive aspects of human performance. Video-occlusion methods perfected by sports expertise researchers have great instructional utility, in some cases offering an effective and inexpensive alternative to high-fidelity simulation. A key problem for instructional designers seems to be that expertise research done in laboratory and field settings doesn't get adequately translated into workplace training. Therefore, this article presents a framework for better linkage of expertise research/training across laboratory, field, and workplace settings. It also uses a case study to trace the development and implementation of a macrocognitive training program in the very challenging workplace of the baseball batters' box. This training, which was embedded for a full season in a college baseball team, targeted the perceptual-cognitive skill of pitch recognition that allows expert batters to circumvent limitations of human reaction time in order to hit a 90 mile-per-hour slider. While baseball batting has few analogous skills outside of sports, the instructional design principles of the training program developed to improve batting have wider applicability and implications. Its core operational principle, supported by information processing models but challenged by ecological models, decouples the perception-action link for targeted part-task training of the perception component, in much the same way that motor components routinely are isolated to leverage instructional efficiencies. After targeted perceptual training, perception and action were recoupled via transfer-appropriate tasks inspired by in situ research tasks. Using NCAA published statistics as performance measures, the cooperating team

  4. Instructional Design for Accelerated Macrocognitive Expertise in the Baseball Workplace

    Directory of Open Access Journals (Sweden)

    Peter J. Fadde

    2016-03-01

    Full Text Available The goal of accelerating expertise can leave researchers and trainers in human factors, naturalistic decision making, sport science, and expertise studies concerned about seemingly insufficient application of expert performance theories, findings and methods for training macrocognitive aspects of human performance. Video-occlusion methods perfected by sports expertise researchers have great instructional utility, in some cases offering an effective and inexpensive alternative to high-fidelity simulation. A key problem for instructional designers seems to be that expertise research done in laboratory and field settings doesn’t get adequately translated into workplace training. Therefore, this article presents a framework for better linkage of expertise research/training across laboratory, field, and workplace settings. It also uses a case study to trace the development and implementation of a macrocognitive training program in the very challenging workplace of the baseball batters’ box. This training, which was embedded for a full season in a college baseball team, targeted the perceptual-cognitive skill of pitch recognition that allows expert batters to circumvent limitations of human reaction time in order to hit a 90 mile-per-hour slider. While baseball batting has few analogous skills outside of sports, the instructional design principles of the training program developed to improve batting have wider applicability and implications. Its core operational principle, supported by information processing models but challenged by ecological models, decouples the perception-action link for targeted part-task training of the perception component, in much the same way that motor components routinely are isolated to leverage instructional efficiencies. After targeted perceptual training, perception and action were recoupled via transfer-appropriate tasks inspired by in situ research tasks. Using NCAA published statistics as performance measures

  5. Mechanical engineering and design criteria for the Magnetically Insulated Transmission Experiment Accelerator

    International Nuclear Information System (INIS)

    A single-unit electron beam accelerator was designed, fabricated, and assembled in Sandia's Technical Area V to conduct magnetically insulated transmission experiments. Results of these experiments will be utilized in the future design of larger, more complex accelerators. This design makes optimum use of existing facilities and equipment. When designing new components, possible future applications were considered as well as compatibility with existing facilities and hardware

  6. Ground motions and its effects in accelerator design

    International Nuclear Information System (INIS)

    This lecture includes a discussion of types of motion, frequencies of interest, measurements at SLAC, some general comments regarding local sources of ground motion at SLAC, and steps that can be taken to minimize the effects of ground motion on accelerators

  7. Computer codes for particle accelerator design and analysis: A compendium. Second edition

    International Nuclear Information System (INIS)

    The design of the next generation of high-energy accelerators will probably be done as an international collaborative efforts and it would make sense to establish, either formally or informally, an international center for accelerator codes with branches for maintenance, distribution, and consultation at strategically located accelerator centers around the world. This arrangement could have at least three beneficial effects. It would cut down duplication of effort, provide long-term support for the best codes, and provide a stimulating atmosphere for the evolution of new codes. It does not take much foresight to see that the natural evolution of accelerator design codes is toward the development of so-called Expert Systems, systems capable of taking design specifications of future accelerators and producing specifications for optimized magnetic transport and acceleration components, making a layout, and giving a fairly impartial cost estimate. Such an expert program would use present-day programs such as TRANSPORT, POISSON, and SUPERFISH as tools in the optimization process. Such a program would also serve to codify the experience of two generations of accelerator designers before it is lost as these designers reach retirement age. This document describes 203 codes that originate from 10 countries and are currently in use. The authors feel that this compendium will contribute to the dialogue supporting the international collaborative effort that is taking place in the field of accelerator physics today

  8. Beam by design: laser manipulation of electrons in modern accelerators

    CERN Document Server

    Hemsing, Erik; Xiang, Dao; Zholents, Alexander

    2014-01-01

    Accelerator-based light sources such as storage rings and free-electron lasers use relativistic electron beams to produce intense radiation over a wide spectral range for fundamental research in physics, chemistry, materials science, biology and medicine. More than a dozen such sources operate worldwide, and new sources are being built to deliver radiation that meets with the ever increasing sophistication and depth of new research. Even so, conventional accelerator techniques often cannot keep pace with new demands and, thus, new approaches continue to emerge. In this article, we review a variety of recently developed and promising techniques that rely on lasers to manipulate and rearrange the electron distribution in order to tailor the properties of the radiation. Basic theories of electron-laser interactions, techniques to create micro- and nano-structures in electron beams, and techniques to produce radiation with customizable waveforms are reviewed. We overview laser-based techniques for the generation ...

  9. Design of Accelerated Fatigue Tests for Flame Free Refrigeration Fittings

    OpenAIRE

    Wilson, Michael; Bowers, Chad D.

    2014-01-01

    Refrigerant leakage from failed braze joints is a multi-billion dollar problem for the global HVAC&R industry. Leaks are typically caused due to mechanical fatigue from extreme pressure cycling, temperature cycling including exposure to freeze/thaw cycles, or vibrational wear induced from rotating electrical machinery. Three tests to accelerate mechanical fatigue were devised to simulate real world extreme conditions to determine possible failure modes of refrigerant components. The first tes...

  10. Instructional Design for Accelerated Macrocognitive Expertise in the Baseball Workplace

    OpenAIRE

    Fadde, Peter J.

    2016-01-01

    The goal of accelerating expertise can leave researchers and trainers in human factors, naturalistic decision making, sport science, and expertise studies concerned about seemingly insufficient application of expert performance theories, findings and methods for training macrocognitive aspects of human performance. Video-occlusion methods perfected by sports expertise researchers have great instructional utility, in some cases offering an effective and inexpensive alternative to high-fidelity...

  11. Shielding design of electron beam accelerators using supercomputer

    International Nuclear Information System (INIS)

    The MCNP5 neutron, electron, photon Monte Carlo transport program was installed on the KISTI's SUN Tachyon computer using the parallel programming. Electron beam accelerators were modeled and shielding calculations were performed in order to investigate the reduction of computation time in the supercomputer environment. It was observed that a speedup of 40 to 80 of computation time can be obtained using 64 CPUs compared to an IBM PC

  12. Linear IFMIF prototype accelerator (LIPAc) control system: design and development

    OpenAIRE

    Calvo Pinto, Julio

    2014-01-01

    Distributed real time control systems in scientific instruments, such as particle accelerators or telescopes, have emerged as a solution to control multiple interconnected devices, which required constant attention and observation, along with a complete integration of each of its parts. This enhancement is provided by the intense technological development that control devices have suffered in recent years. With respect to the control software, libraries and applications have also emerged in r...

  13. Design study of double-layer beam trajectory accelerator based on the Rhodotron structure

    Science.gov (United States)

    Jabbari, Iraj; Poursaleh, Ali Mohammad; Khalafi, Hossein

    2016-08-01

    In this paper, the conceptual design of a new structure of industrial electron accelerator based on the Rhodotron accelerator is presented and its properties are compared with those of Rhodotron-TT200 accelerator. The main goal of this study was to reduce the power of RF system of accelerator at the same output electron beam energy. The main difference between the new accelerator structure with the Rhodotron accelerator is the length of the coaxial cavity that is equal to the wavelength at the resonant frequency. Also two sets of bending magnets were used around the acceleration cavity in two layers. In the new structure, the beam crosses several times in the coaxial cavity by the bending magnets around the cavity at the first layer and then is transferred to the second layer using the central bending magnet. The acceleration process in the second layer is similar to the first layer. Hence, the energy of the electron beam will be doubled. The electrical power consumption of the RF system and magnet system were calculated and simulated for the new accelerator structure and TT200. Comparing the calculated and simulated results of the TT200 with those of experimental results revealed good agreement. The results showed that the overall electrical power consumption of the new accelerator structure was less than that of the TT200 at the same energy and power of the electron beam. As such, the electrical efficiency of the new structure was improved.

  14. Jacobs Engineering Group Inc. receives architectural and engineering design contract from Stanford Linear Accelerator Centre

    CERN Multimedia

    2004-01-01

    "Jacobs Engineering Group Inc. announced that a subsidiary company won a contract from Stanford Linear Accelerator Center (SLAC), to provide architectural and engineering design services for the Linac Coherent Light Source (LCLS) conventional facilities" (1/2 page)

  15. Design of On-chip Power Transport and Coupling Components for a Silicon Woodpile Accelerator

    International Nuclear Information System (INIS)

    Three-dimensional woodpile photonic bandgap (PBG) waveguide enables high-gradient and efficient laser driven acceleration, while various accelerator components, including laser couplers, power transmission lines, woodpile accelerating and focusing waveguides, and energy recycling resonators, can be potentially integrated on a single monolithic structure via lithographic fabrications. This paper will present designs of this on-chip accelerator based on silicon-on-insulator (SOI) waveguide. Laser power is coupled from free-space or fiber into SOI waveguide by grating structures on the silicon surface, split into multiple channels to excite individual accelerator cells, and eventually gets merged into the power recycle pathway. Design and simulation results will be presented regarding various coupling components involved in this network.

  16. A Study of the Design of Acceleration Control System for Missiles

    Science.gov (United States)

    Kajita, Takanori; Eguchi, Hirofumi

    A 2-degrees of freedom PID controller is designed for a maneuvering acceleration control system. This design method is based on the combination of PID and IPD controller. Results show that (1) IP controller is superior to PI controller for the damper loop controller, (2) the selection of PI or IP controller as for the acceleration controller depends on the tradeoffs between the responsibility and the reduction of inverse response.

  17. Design and development of pulsed electron beam accelerator 'AMBICA - 600'

    Science.gov (United States)

    Verma, Rishi; Deb, Pankaj; Shukla, Rohit; Sharma, Surender; Shyam, Anurag

    2012-11-01

    Short duration, high power pulses with fast rise time and good flat-top are essentially required for driving pulsed electron beam diodes. To attain this objective, a dual resonant Tesla transformer based pulsed power accelerator 'AMBICA-600' has been developed. In this newly developed system, a coaxial water line is charged through single turn Tesla transformer that operates in the dual resonant mode. For making the accelerator compact, in the high power pulse forming line, water has been used as dielectric medium because of its high dielectric constant, high dielectric strength and high energy density. The coaxial waterline can be pulsed charged up to 600kV, has impedance of ~5Ω and generates pulse width of ~60ns. The integrated system is capable of producing intense electron beam of 300keV, 60kA when connected to impedance matched vacuum diode. In this paper, system hardware details and experimental results of gigawatt electron beam generation have been presented.

  18. Design and validation of wireless acceleration sensor network for structural health monitoring

    Institute of Scientific and Technical Information of China (English)

    Yu Yan; Ou Jinping

    2006-01-01

    A wireless sensor network is proposed to monitor the acceleration of structures for the purpose of structural health monitoring of civil engineering structures. Using commercially available parts, several modules are constructed and integrated into complete wireless sensors and base stations. The communication protocol is designed and the fusion arithmetic of the temperature and acceleration is embedded in the wireless sensor node so that the measured acceleration values are more accurate. Measures are adopted to finish energy optimization, which is an important issue for a wireless sensor network. The test is performed on an offshore platform model, and the experimental results are given to show the feasibility of the designed wireless sensor network.

  19. On designing a control system for a new generation of accelerators

    International Nuclear Information System (INIS)

    A well-conceived plan of attack is essential to the task of designing a control system for a large accelerator. Several aspects of such a plan have been investigated during recent work at LAMPF on design strategies for an Advanced Hadron Facility control system. Aspects discussed in this paper include: identification of requirements, creation and enforcement of standards, interaction with users, consideration of commercial controls products, integration with existing control systems, planning for continual change, and establishment of design reviews. We emphasize the need for the controls group to acquire and integrate accelerator design information from the start of the design process. We suggest that a controls design for a new generation of accelerators be done with a new generation of software tools. 12 refs

  20. Design and test of a superconducting magnet in a linear accelerator for an Accelerator Driven Subcritical System

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Quanling, E-mail: pengql@ihep.ac.cn [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Xu, Fengyu [Harbin Institute of Technology, Heilongjiang 150006 (China); Wang, Ting [Beijing Huantong Special Equipment Co., LTD, Beijing 100192 (China); Yang, Xiangchen [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Chen, Anbin [Harbin Institute of Technology, Heilongjiang 150006 (China); Wei, Xiaotao [Beijing Huantong Special Equipment Co., LTD, Beijing 100192 (China); Gao, Yao; Hou, Zhenhua; Wang, Bing; Chen, Yuan; Chen, Haoshu [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2014-11-11

    A batch superconducting solenoid magnet for the ADS proton linear accelerator has been designed, fabricated, and tested in a vertical dewar in Sept. 2013. A total of ten superconducting magnets will be installed into two separate cryomodules. Each cryomodule contains six superconducting spoke RF cavities for beam acceleration and five solenoid magnets for beam focusing. The multifunction superconducting magnet contains a solenoid for beam focusing and two correctors for orbit correction. The design current for the solenoid magnet is 182 A. A quench performance test shows that the operating current of the solenoid magnet can reach above 300 A after natural quenching on three occasions during current ramping (260 A, 268 A, 308 A). The integrated field strength and leakage field at the nearby superconducting spoke cavities all meet the design requirements. The vertical test checked the reliability of the test dewar and the quench detection system. This paper presents the physical and mechanical design of the batch magnets, the quench detection technique, field measurements, and a discussion of the residual field resulting from persistent current effects.

  1. AEi systems designing power sstem for world's largest particle accelerator

    CERN Multimedia

    Weinberg, Lee

    2007-01-01

    "AEi Systems, a world leader in power systems analysis and design, announced today that the Large Hadron Collider (LHC) at CERN (the European Centre for Nuclear Research) near Geneva, Switzerland, has engaged AEi Systems to design and develop a radiation-hard power supply for CERN's giant ATLAS particle detector." (1 page)

  2. Structure and process design of separated function radio frequency quadruple accelerator

    International Nuclear Information System (INIS)

    The construction features of separated function radio frequency quadrupole(SFRFQ) accelerator are presented, which include the structure of diaphragms electrodes, integral split ring supporting system, cooling system, tuning system and their manufacturing engineering. The analysis with 8753ES network analyzer proves that the tuning system works successfully to tune the SFRFQ frequency at 26.07 MHz as required by the whole acceleration system without significant quality factor declining. The Roentgen spectrum test at high power proves that the inter-vane Jantage can reach higher than the design value of 70 kV. Beam commissioning was carried out to accelerate the O+ ions from 1.03 MeV to 1.65 MeV, which demonstrates that the mechanical design of SFRFQ accelerator can satisfy the experimental demands and the SFRFQ prototype cavity runs stably as designed. (authors)

  3. Design studies of a high-current radiofrequency quadrupole for accelerator-driven systems programme

    Indian Academy of Sciences (India)

    S V L S Rao; P Singh

    2010-02-01

    A 3 MeV, 30 mA radiofrequency quadrupole (RFQ) accelerator has been designed for the low-energy high-intensity proton accelerator (LEHIPA) project at BARC, India. The beam and cavity dynamics studies were performed using the computer codes LIDOS, TOUTATIS, SUPERFISH and CST microwave studio. We have followed the conventional design technique with slight modifications and compared that with the equipartitioned (EP) type of design. The sensitivity of the RFQ to the variation of input beam Twiss–Courant parameters and emittance has also been studied. In this article we discuss both design strategies and the details of the 3D cavity simulation studies.

  4. Genetic Algorithms for the Optimal Design of Superconducting Accelerator Magnets

    CERN Document Server

    Ramberger, S

    1998-01-01

    The paper describes the use of genetic algorithms with the concept of niching for the optimal design of superconducting magnets for the Large Hadron Collider, LHC at CERN. The method provides the designer with a number of local optima which can be further examined with respect to objectives such as ease of coil winding, sensitivity to manufacturing tolerances and local electromagnetic force distribution. A 6 block dipole coil was found to have advantages compared to the standard 5 block version which was previously designed using deterministic optimization methods. Results were proven by a short model magnet recently built and tested at CERN.

  5. Linear Accelerator Test Facility at LNF Conceptual Design Report

    CERN Document Server

    Valente, Paolo; Bolli, Bruno; Buonomo, Bruno; Cantarella, Sergio; Ceccarelli, Riccardo; Cecchinelli, Alberto; Cerafogli, Oreste; Clementi, Renato; Di Giulio, Claudio; Esposito, Adolfo; Frasciello, Oscar; Foggetta, Luca; Ghigo, Andrea; Incremona, Simona; Iungo, Franco; Mascio, Roberto; Martelli, Stefano; Piermarini, Graziano; Sabbatini, Lucia; Sardone, Franco; Sensolini, Giancarlo; Ricci, Ruggero; Rossi, Luis Antonio; Rotundo, Ugo; Stella, Angelo; Strabioli, Serena; Zarlenga, Raffaele

    2016-01-01

    Test beam and irradiation facilities are the key enabling infrastructures for research in high energy physics (HEP) and astro-particles. In the last 11 years the Beam-Test Facility (BTF) of the DA{\\Phi}NE accelerator complex in the Frascati laboratory has gained an important role in the European infrastructures devoted to the development and testing of particle detectors. At the same time the BTF operation has been largely shadowed, in terms of resources, by the running of the DA{\\Phi}NE electron-positron collider. The present proposal is aimed at improving the present performance of the facility from two different points of view: extending the range of application for the LINAC beam extracted to the BTF lines, in particular in the (in some sense opposite) directions of hosting fundamental physics and providing electron irradiation also for industrial users; extending the life of the LINAC beyond or independently from its use as injector of the DA{\\Phi}NE collider, as it is also a key element of the electron/...

  6. Design of an electromagnetic accelerator for turbulent hydrodynamic mix studies. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Susoeff, A.R.; Hawke, R.S.; Morrison, J.J.; Dimonte, G.; Remington, B.A.

    1994-03-01

    An electromagnetic accelerator in the form of a linear electric motor (LEM) has been designed to achieve controlled acceleration profiles of a carriage containing hydrodynamically unstable fluids for the investigation of the development of turbulent mix. Key features of the design include: (1) independent control of acceleration, deceleration and augmentation currents to provide a variety of acceleration-time profiles, (2) a robust support structure to minimized deflection and dampen vibration which could create artifacts in the data interfering with the intended study and (3) a compliant, non-arcing solid armature allowing optimum electrical contact. Electromagnetic modeling codes were used to optimize the rail and augmentation coil positions within the support structure framework. Design of the driving armature and the dynamic electromagnetic braking system is based on results of contemporary studies for non-arcing sliding contact of solid armatures. A 0.6MJ electrolytic capacitor bank is used for energy storage to drive the LEM. This report will discuss a LEM and armature design which will accelerate masses of up to 3kg to a maximum of about 3000g{sub o}, where g{sub o} is acceleration due to gravity.

  7. Design of 10 MeV cyclotron accelerator

    Directory of Open Access Journals (Sweden)

    R Solhju

    2015-09-01

    Full Text Available Design and construction of 10MeV cyclotron has been started at Amirkabir University of Technology since 2012. So far, the conceptual and detail engineering design phases have been finalized. The main purpose of this baby cyclotron is to generate proton beam for the production of PET radioisotopes. The cyclotron consists of magnet, cavity, ion source, RF and LLRF system, vacuum system, cooling system, power amplifiers and power supplies system. In this paper, a brief of design principles for all the parts of cyclotron and their final simulation results is presented. It should be noted that these simulations have been performed and optimized by the most accurate softwares such as TOSCA, ANSYS, HFSS, SolidWorks and CST. Also, the manufacturing feasibility of all the parts is performed and their dimensions and parameters are synchronized with manufacturing standards

  8. A conceptual design of the RF system for the NSP high intensity proton accelerator at JAERI

    International Nuclear Information System (INIS)

    JAERI has been proposing the Neutron Science Project which aims at exploring the fields of basic science and nuclear technology using a high power spallation neutron source. The neutron source will be driven by a high intensity linear accelerator with an energy of 1.5 GeV and an average beam current of 5.33 mA and beam power of 8 MW. The RF system for the accelerator consists of a high-energy accelerator part and a low energy accelerator part. The maximum RF power requirements at the high and low energy accelerator parts are 25 MW and 8.3 MW, respectively. In this report, we describe the conceptual design of the RF system. In the low energy accelerator part, we estimated the requirement for the high-power amplifier tube and made the basis design for RF components. In the high energy accelerator part, we studied the effect of tuning errors, Lorentz forces and microphonics in the superconducting cavity. We calculated the klystron efficiency and supply power in the arrangement of where one klystron distributes the RF power to four cavities. We also considered an IOT RF system. Finally, we describe the electrical capacity and quantity of cooling water in the RF system. (author)

  9. LLNL Precision Compton Scattering Light Source: X-band RF Photoinjector and Accelerator Design

    Science.gov (United States)

    Marsh, Roark; Anderson, S. G.; Gibson, D. J.; Wu, S. S.; Hartemann, F. V.; Houck, T. L.; Ebbers, C.; Scarpetti, R. D.; Barty, C. P. J.; Adolphsen, C.; Chu, T. S.; Li, Z.; Tantawi, S. G.; Vlieks, A. E.; Wang, J. W.; Raubenheimer, T. O.

    2010-11-01

    The design and optimization of a Mono-Energetic Gamma-Ray (MEGa-Ray) Compton scattering source are presented. This precision light source with up to 2.5 MeV photon energy is currently being built at LLNL using high gradient X-band accelerator technology in collaboration with SLAC. The design of a high brightness 5.59 cell X-band RF photoinjector will be presented. An ``early light'' machine has been designed using the 250 pC, <1mm-mrad electron bunches from the photoinjector, a single T53 traveling wave accelerator section, and Joule-class diode pumped laser pulses to produce diagnostic Compton scattered photons. Design of this ``early-light'' machine will be presented with discussion of the various components, layout considerations, and plans for the full 250 MeV linear accelerator.

  10. Scaling of induction-cell transverse impedance: effect on accelerator design

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Carl August [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-09

    The strength of the dangerous beam breakup (BBU) instability in linear induction accelerators (LIAs) is characterized by the transverse coupling impedance Z . This note addresses the dimensional scaling of Z , which is important when comparing new LIA designs to existing accelerators with known i BBU growth. Moreover, it is shown that the scaling of Z with the accelerating gap size relates BBU growth directly to highvoltage engineering considerations. It is proposed to firmly establish this scaling though a series of AMOS calculations.

  11. Scaling of induction-cell transverse impedance: effect on accelerator design

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Carl August [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-09

    The strength of the dangerous beam breakup (BBU) instability in linear induction accelerators (LIAs) is characterized by the transverse coupling impedance Z. This note addresses the dimensional scaling of Z, which is important when comparing new LIA designs to existing accelerators with known i BBU growth. Moreover, it is shown that the scaling of Z with the accelerating gap size relates BBU growth directly to high-voltage engineering considerations. It is proposed to firmly establish this scaling though a series of AMOS calculations.

  12. Design concept of radiation control system for the high intensity proton accelerator facility

    Energy Technology Data Exchange (ETDEWEB)

    Miyamoto, Yukihiro; Ikeno, Koichi; Akiyama, Shigenori; Harada, Yasunori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2002-11-01

    Description is given for the characteristic radiation environment for the High Intensity Proton Accelerator Facility and the design concept of the radiation control system of it. The facility is a large scale accelerator complex consisting of high energy proton accelerators carrying the highest beam intensity in the world and the related experimental facilities and therefore provides various issues relevant to the radiation environment. The present report describes the specifications for the radiation control system for the facility, determined in consideration of these characteristics. (author)

  13. Comparison of depth-dose distributions between reactor and accelerator neutron beams proposed by design studies

    International Nuclear Information System (INIS)

    Accelerator epithermal neutron beams produced by 7Li(p,n)7Be reactions were compared with reactor neutron beams using a fission converter (20% enriched 235U 5mm-thick plate) from view points of neutron spectrum and depth-dose distributions in a phantom. It is possible to design accelerator epithermal neutron beams having better depth-dose distributions than reactor neutron beams. (author)

  14. Missile Acceleration Controller Design using PI and Time-Delay Adaptive Feedback Linearization Methodology

    OpenAIRE

    Lee, Chang-Hun; Seo, Min-Guk; Tahk, Min-Jea; Lee, Jin-Ik; Jun, Byung-Eul

    2012-01-01

    A straight forward application of feedback linearization to the missile autopilot design for acceleration control may be limited due to the nonminimum characteristics and the model uncertainties. As a remedy, this paper presents a cascade structure of an acceleration controller based on approximate feedback linearization methodology with a time-delay adaptation scheme. The inner loop controller is constructed by applying feedback linearization to the approximate system which is a minimum phas...

  15. ACCELERATORS: Study of the design of CSNS MEBT

    Science.gov (United States)

    Ouyang, Hua-Fu; Liu, Hua-Chang; Fu, Shi-Nian

    2009-07-01

    The design of CSNS MEBT has two objectives: (1) to match the beam both in the transversal direction and the longitudinal direction from RFQ into DTL; (2) to further chop the beam into the required time structure asked by RCS. It is very difficult and critical to control well the emittance growth and in the meantime to match and chop the beam. Firstly, the optical design is done and optimized, and the multi-particle simulations show that the maximum emittance growth is successfully controlled within 14%. Secondly, based on the different beam envelopes obtained by TRACE-3D and PARMELA, the least deflecting angle of the chopper is determined by TRACE-3D. At last, the field of steering magnet is determined through simulations.

  16. Lattice Design in High-energy Particle Accelerators

    CERN Document Server

    Holzer, B J

    2014-01-01

    This lecture gives an introduction into the design of high-energy storage ring lattices. Applying the formalism that has been established in transverse be am optics, the basic principles of the development of a magnet lattice are explained and the characteristics of the resulting magnet structure are discussed. The periodic assembly of a storage ring cell with its boundary conditions concerning stability and scaling of the beam optics parameters is addressed as well as special lattice insertions such as drifts, mini beta sections, dispersion suppressors, etc. In addition to the exact calculations that are indispensable for a rigorous treatment of the matter, scaling rules are shown and simple rules of thumb are included that enable the lattice designer to do the first estimates and get the basic numbers ‘ on the back of an envelope.

  17. Accelerator production of tritium pollution prevention design assessment

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, R.; Nowacki, P.; Sheetz, S.O. [Westinghouse Savannah River Co., Aiken, SC (United States); Lanik, P. [Burns and Roe Engineering Inc. (United States)

    1997-09-18

    This Pollution Prevention Design Assessment (PPDA) provides data for cost-benefit analysis of the potential environmental impact of the APT, is an integral part of pollution prevention/waste minimization, and is required by DOE for any activity generating radioactive, hazardous, and mixed wastes. It will also better position the APT to meet future requirements, since it is anticipated that regulatory and other requirements will continue to become more restrictive and demanding.

  18. Accelerator production of tritium pollution prevention design assessment

    International Nuclear Information System (INIS)

    This Pollution Prevention Design Assessment (PPDA) provides data for cost-benefit analysis of the potential environmental impact of the APT, is an integral part of pollution prevention/waste minimization, and is required by DOE for any activity generating radioactive, hazardous, and mixed wastes. It will also better position the APT to meet future requirements, since it is anticipated that regulatory and other requirements will continue to become more restrictive and demanding

  19. Non scaling fixed field gradient accelerator design for proton and carbon therapy

    International Nuclear Information System (INIS)

    The Fixed Field Alternating Gradient (FFAG) accelerators became again a subject of great interest in many accelerator physics applications, after more than fifty years of their first appearance. The original FFAG's are the 'scaling' design where particle orbits during acceleration scale with momentum. In Japan a number of scaling FFAG's have been built, or are under construction. The original designs are proposed and used in many applications: proton acceleration in medical field for cancer therapy, electron acceleration for the low (food radiation, electron demonstration ring) and high energies (future e-RHIC 10 GeV), acceleration of muons (the 'PRISM'-project in Japan), proton acceleration for the AGS upgrade at Brookhaven National Laboratory, etc. There are many advantages of the scaling FFAG with respect to the today common use of synchrotrons, cyclotrons, or linear accelerators-linacs: the magnetic field is fixed, possibility of high repetition rate. Disadvantages of the scaling FFAG are the large required aperture and large circumference. This is due to the scaling law between the orbit and momentum and the relatively large opposite bending field requirement. This proposed non-scaling design had been extensively investigated in many respects. A European proposal to build a non-scaling FFAG electron demonstration ring is in progress. Recent international CYCLOTRON conference had dedicated time for the update on the FFAG acceleration. The non-scaling FFAG's should dramatically reduce required aperture and circumferences. If the fixed magnetic field produces the linear gradient, there is a tune variation during fast acceleration and resonances are a crossed. The small dispersion function and strong focusing in this design reduces the aperture size for almost an order of magnitude with respect to standard scaling FFAG design. We present one of the possible applications of the non-scaling proton and carbon cancer therapy FFAG accelerator. The cancer proton therapy

  20. The mechatronic design of a fast wire scanner in IHEP U-70 accelerator

    Science.gov (United States)

    Baranov, V. T.; Makhov, S. S.; Savin, D. A.; Terekhov, V. I.

    2016-10-01

    This paper presents the mechatronic design of a fast wire scanner based on a servomotor. The design of the wire scanner is motivated by the need to measure the transverse profile of the high power proton and carbon beams at the IHEP U-70 accelerator. This paper formulates the requirements to the fast wire scanner system for the high intensity proton beam at the U-70 accelerator. The results on the design of electro-mechanical device for the wire scanner with a wire traveling speed 10-20 m/s are presented. The solution consists in a brushless servomotor and standard motor control electronics. High radiation levels in the accelerator enclosure dictate the use of a resolver as the position feedback element.

  1. Engineering design and fabrication of tapered damped X-Band accelerating structures

    CERN Document Server

    Solodko, A; Gudkov, D; Riddone, G; Grudiev, A; Atieh, S; Taborelli, M

    2011-01-01

    The accelerating structures (AS) are one of the main components of the Compact LInear Collider (CLIC), under study at CERN. Each accelerating structure contains about 30 copper discs, which form the accelerating cavity. The requirements of different technical systems, such as vacuum and cooling, have to be considered during the engineering design. A fully featured AS is very challenging and requires several technologies. Different damping methods, waveguides, vacuum manifolds, slots and chokes, result in various design configurations. In the CLIC AS each cell is damped by means of four waveguides coupled to the cell. The vacuum manifolds combine a number of functions such as damping, vacuum pumping and cooling. A silicon carbide absorber, fixed inside of each manifold, is required for effective damping of Higher Order Modes (HOMs). This paper describes the engineering design of the X-band AS with damping material, and focuses on few technical solutions.

  2. Design and development of power supplies at VECC for accelerators

    International Nuclear Information System (INIS)

    Several power supplies have been designed and developed in-house incorporating various topologies to match the load requirements. Most of the power supplies have been being utilised in K-130 and K-500 cyclotrons operation successfully from last several years. Amongst other types, Switching Mode PS (SMPS), Phase Controlled Rectifier (PCR), Linear mode power supply are mostly in use, irrespective of their own merits and demerits. Switching mode power supply (SMPS) is most common topology for various applications ranging from high current to high voltage applications. Due to low stored energy and faster response, the SMPS incorporating Pulse Switch Modulation (PSM) configuration is most suitable for high voltage DC power supply at larger power compared to its counterparts, makes possible to operate the power system without crowbar. For an IOT cathode power supply, a 200kW at - 40kV High voltage power supply is under development incorporating SMPS and PSM technique. Earlier, High Voltage power supply was made by using Tetrode Tube in linear mode for RF amplifier for K-130 Cyclotron. Later, in K-500 Cyclotron, a High Voltage power supply was developed incorporating PCR topology rated at 20kV, 20 Amp for Anodes for 3 nos. of RF amplifiers. These HV power supply is equipped with ultra-fast acting Crowbar Protection System developed in VECC which is for the protection of costly RF Tubes against the internal arc. Design and development of SMPS based Bipolar Power Supply with 4-Quadrant operation rated at ± 27 V, ± 300 Amp with current stability around 100 ppm for Super-conducting Magnets along with quench protection and energy dumping scheme. (author)

  3. On the application of design of experiments to accelerated life testing

    International Nuclear Information System (INIS)

    Today, there is an increasing demand for improved quality and reliability due to increasing system complexity and increasing demands from customer. Continuous improvement of quality is not only a means of competition but also a matter of staying in the market. Accelerated life testing and statistical design of experiments are two needed methods for improvement of quality. The combined use of them is very advantageous and increases the test efficiency. Accelerated life testing is a quick way to provide information on the life distribution of materials and products. By subjecting the test unit to conditions more severe than those at normal usage, the test time can be highly reduced. Estimates of life at normal stress levels are obtained by extrapolating the available information through a reasonable acceleration model. Accelerated life testing has mostly been used to measure reliability but it is high time to use it for improvement of quality. Design of experiments serves to find out the effect of design parameters and other interesting factors on performance measure and its variability. The obtained information is essential for a continuous improvement of quality. As an illustration, two sets of experiment are designed and performed at highly increased stress levels. The results are analysed and discussed and a time saving alternative is proposed. The combination of experimental design and accelerated life testing is discussed and illustrated. The combined use of these methods can be argued for in two different cases. One is for an exploratory improvement investigation and the other is for verification of reliability. In either case, the combined use is advantageous and improves the testing efficiency. Some general conclusions are drawn to be used for planning and performance of statistically designed accelerated life testing experiments. (70 refs.) (au)

  4. Design of light Ⅱ-B pulsed power electron accelerator

    International Nuclear Information System (INIS)

    The Light Ⅱ-B was built at the side of the Marx tank of Light Ⅱ-A for X-pinch test, which kept the original capacity of KrF excimer laser, and can be used for relevant researches of X-pinch. It is composed of a Marx generator, a pulse forming line (PFL), a gas-filled switch, a pulse transmission line (PTL), and a copper-sulphate resistive load. The medium of the forming line is deionized water. The input impendence of the pulse forming line is 6 Ω, corresponding to an output impendence of 1.25 Ω for the pulse transfer line. The design of circuit simulation and the debugging results in resistance load were introduced. The results show that the current peak load is about 269 kA, pulse width is about 50 ns, and the current rise tune is less than 30 ns when the load is 1.25 Ω. It indicates that Light Ⅱ-B has the ability to drive low impedance X-pinch experimental line. (authors)

  5. Design of an RFQ Accelerator optimised for Linac4 and SPL

    CERN Document Server

    Lombardi, A M; Vretenar, M; CERN. Geneva. AB Department

    2007-01-01

    In the Linac 4 and the SPL a 3 MeV RFQ is required to accelerate the H- beam from the ion source to the DTL input energy. The IPHI RFQ, primarily designed for high beam power applications, is presently being built within a collaboration between CEA, IN2P3 and CERN and is intended to become the front end for the new CERN accelerator complex. However, a new shorter RFQ optimised for the CERN lower duty application would present several advantages with respect to the IPHI one. The design of such an RFQ is the subject of this note.

  6. Shielding design of a mobile electron accelerator using Monte Carlo technique

    International Nuclear Information System (INIS)

    Shielding of a mobile electron accelerator of 0.6 MeV, 33 mA has been designed and examined by Monte Carlo technique. Based on a 3-D model of electron accelerator shielding which is designed with steel and lead shield, radiation leakage was examined using the MCNP code. Calculations using two different versions (version 4C2 and version 5) of MCNP showed agreements within statistical uncertainties, and the highest leakage expected is 5.5061 x 10-1 (1 ± 0.0454) μSvh-1, which is far below the tolerable radiation dose limit of 1 mSv (week)-1

  7. Theoretical study of self-balancing missiles. [design for maximum vertical or lateral accelerations

    Science.gov (United States)

    Hopkins, E. J.

    1976-01-01

    A theoretical study based on linear theory is presented for two types of 'self-balancing' missiles, designed to accelerate vertically or laterally without pitching or yawing. One type of missile had a variable-incidence wing and the other type had wing flaps to provide acceleration. The main objective of this investigation is to compare the maximum available acceleration for these self-balancing missiles with that of conventional pitching-type missiles. Ten different configurations were considered. The results indicate that self-balancing missiles with either variable wing incidence or wing flaps are feasible, but that the maximum available acceleration for these missiles is less than for a conventional pitching-type missile having the same wing and tail surfaces.

  8. Sulfur hexafluoride reprocessing system design for a large pulsed power accelerator

    International Nuclear Information System (INIS)

    The Particle Beam Fusion Accelerator-II (PBFA-II) is a large, high power accelerator being constructed at Sandia National Labs to conduct research in inertial confinement fusion. One key to the success of this machine is the ability to produce an electrical pulse at the target with a well defined shape (power versus time). In the past at Sandia National Labs, a commercial SF6 reclaimer unit has been used to reprocess vapor. These reclaimers are well designed for their primary purpose-the reprocessing of substation transformer and circuit breaker vapor for the electrical generation industry. They are not designed to meet the more exacting needs of a research accelerator such as PBFA-II. An SF6 reprocessing system was designed for use in PBFA-II to overcome the deficiencies found in commercial reclaimers. This paper describes the requirements placed on an SF6 reprocessing system when operating in a fusion research accelerator, resulting in criteria used to design the reprocessing system, and the subsequent design implemented to meet these criteria

  9. ESS-Bilbao light-ion linear accelerator and neutron source: design and applications

    International Nuclear Information System (INIS)

    The baseline design for the ESS-Bilbao light-ion linear accelerator and neutron source has been completed and the normal conducting section of the linac is at present under construction. The machine has been designed to be compliant with ESS specifications following the international guidelines of such project as described in Ref. [1]. The new accelerator facility in Bilbao will serve as a base for support of activities on accelerator physics carried out in Spain and southern Europe in the frame of different ongoing international collaborations. Also, a number of applications have been envisaged in the new Bilbao facility for the outgoing light ion beams as well as from fast neutrons produced by low-energy neutron-capture targets, which are briefly described.

  10. Design and construction of a 33 GHz brazed accelerator waveguide for high gradient operation

    International Nuclear Information System (INIS)

    This paper discusses design and construction features of a precision machined and brazed traveling wave structure for use as a high gradient 33.3 GHz electron linear accelerator test section in a Two Beam Accelerator. Design emphasis was directed at meeting an RF filling time requirement of 12F<16ns, and at fabricating a test structure that would provide guidelines for demonstrating average accelerating fields of approximately 300 MV/m (maximum surface fields of 650 MV/m). Microwave measurement data, obtained during construction, are described and include a phase dispersion simple cold test technique for accurately predicting the structure filling time. A companion paper discusses plans for high power testing of both this brazed structure and a hybrid brazed/electroformed structure, using the Electron Laser Facility ELF at LLNL

  11. DTL cavity design and beam dynamics for a TAC linear proton accelerator

    Science.gov (United States)

    Caliskan, A.; Yılmaz, M.

    2012-02-01

    A 30 mA drift tube linac (DTL) accelerator has been designed using SUPERFISH code in the energy range of 3-55 MeV in the framework of the Turkish Accelerator Center (TAC) project. Optimization criteria in cavity design are effective shunt impedance (ZTT), transit-time factor and electrical breakdown limit. In geometrical optimization we have aimed to increase the energy gain in each RF gap of the DTL cells by maximizing the effective shunt impedance (ZTT) and the transit-time factor. Beam dynamics studies of the DTL accelerator have been performed using beam dynamics simulation codes of PATH and PARMILA. The results of both codes have been compared. In the beam dynamical studies, the rms values of beam emittance have been taken into account and a low emittance growth in both x and y directions has been attempted.

  12. DTL cavity design and beam dynamics for a TAC linear proton accelerator

    Institute of Scientific and Technical Information of China (English)

    A. Caliskan; M. Yi1maz

    2012-01-01

    A 30 mA drift tube linac (DTL) accelerator has been designed using SUPERFISH code in the energy range of 3-55 MeV in the framework of the Turkish Accelerator Center (TAC) project.Optimization criteria in cavity design are effective shunt impedance (ZTT),transit-time factor and electrical breakdown limit.In geometrical optimization we have aimed to increase the energy gain in each RF gap of the DTL cells by maximizing the effective shunt impedance (ZTT) and the transit-time factor.Beam dynamics studies of the DTL accelerator have been performed using beam dynamics simulation codes of PATH and PARMILA.The results of both codes have been compared.In the beam dynamical studies,the rms values of beam emittance have been taken into account and a low emittance growth in both x and y directions has been attempted.

  13. CEBAF [Continuous Electron Beam Accelerator Facility] design overview and project status

    International Nuclear Information System (INIS)

    This paper discusses the design and specifications of the Continuous Electron Beam Accelerator Facility. Beam performance objectives are discussed, as well as the recirculating linac concept, the injector, cavities, cryogenic system, beam transport and optics, rf system and construction progress. 19 refs., 10 figs

  14. Mechanical design and construction of a 200 mA, 100 keV, dc, negative ion accelerator

    International Nuclear Information System (INIS)

    A volume production source and a 100 keV, dc, accelerator together with an additional, modular, 100 keV, electro static focused accelerator provide a starting point for a high energy H-/D- beam-line (200 keV to 800 keV), intended for fusion energy applications. The 100 keV accelerator tests started in June 1987. The mechanical design and construction of the accelerator is described. 3 refs., 8 figs

  15. A novel approach for high precision rapid potentiometric titrations: Application to hydrazine assay

    Science.gov (United States)

    Sahoo, P.; Malathi, N.; Ananthanarayanan, R.; Praveen, K.; Murali, N.

    2011-11-01

    We propose a high precision rapid personal computer (PC) based potentiometric titration technique using a specially designed mini-cell to carry out redox titrations for assay of chemicals in quality control laboratories attached to industrial, R&D, and nuclear establishments. Using this technique a few microlitre of sample (50-100 μl) in a total volume of ˜2 ml solution can be titrated and the waste generated after titration is extremely low comparing to that obtained from the conventional titration technique. The entire titration including online data acquisition followed by immediate offline analysis of data to get information about concentration of unknown sample is completed within a couple of minutes (about 2 min). This facility has been created using a new class of sensors, viz., pulsating sensors developed in-house. The basic concept in designing such instrument and the salient features of the titration device are presented in this paper. The performance of the titration facility was examined by conducting some of the high resolution redox titrations using dilute solutions--hydrazine against KIO3 in HCl medium, Fe(II) against Ce(IV) and uranium using Davies-Gray method. The precision of titrations using this innovative approach lies between 0.048% and 1.0% relative standard deviation in different redox titrations. With the evolution of this rapid PC based titrator it was possible to develop a simple but high precision potentiometric titration technique for quick determination of hydrazine in nuclear fuel dissolver solution in the context of reprocessing of spent nuclear fuel in fast breeder reactors.

  16. Design and operation of an inverse free-electron-laser accelerator in the microwave regime

    Science.gov (United States)

    Yoder, Rodney Bruce

    2000-09-01

    A novel electron accelerator demonstrating the inverse free-electron-laser (IFEL) principle has been designed, built, and operated using radio-frequency power at 2.856 GHz. Such an accelerator uses a stationary, periodic magnetic field to impart transverse motion to charged particles, which are then accelerated by guided electromagnetic waves. The experiment described here demonstrates for the first time the phase dependence of IFEL acceleration. This design uses up to 15 MW of RF power propagating in a smooth-walled circular waveguide surrounded by a pulsed bifilar helical undulator; an array of solenoids provides an axial guiding magnetic field undulator; pitch, which is initially 11.75 cm, is linearly increased to 12.3 cm. over the 1-meter length of the structure to maintain acceleration gradient. Numerical computations predict an energy gain of up to 0.7 MeV using a 6 MeV injected beam from a 2-1/2 cell RF gun, with small energy spread and strong phase trapping. The initial injection phase is the most important parameter, determining the rate of energy gain or loss. These simulations are compared with experimental measurements at low power in which electron beams at energies between 5 and 6 MeV gain up to 0.35 MeV with minimal energy spread, all exiting particles having been accelerated. The predicted phase sensitivity of the mechanism is verified, with beams injected into accelerating phases gaining energy cleanly while those injected into ``decelerating'' phases are shown to be degraded in quality and hardly changed in energy, demonstrating the asymmetry of a tapered-wiggler design. Agreement with simulation is very good for accelerating phases, though less exact otherwise. Scaling to higher power and frequency is investigated. The maximum attainable acceleration gradient for a MIFELA using 150 MW of RF power at 34 GHz is estimated to be at least 30 MV/m, and laser IFELs could conceivably reach gradients in the GeV/m range.

  17. Accelerator System Design, Injection, Extraction and Beam-Material Interaction: Working Group C Summary Report

    CERN Document Server

    Mokhov, N V

    2014-01-01

    The performance of high beam power accelerators is strongly dependent on appropriate injection, acceleration and extraction system designs as well as on the way interactions of the beam with machine components are handled. The experience of the previous ICFA High -Brightness Beam workshops has proven that it is quite beneficial to combine analyses and discussion of these issues in one group. A broad range of topics was presented and discussed at the Working Group C sessions at the HB2012 Workshop. Highlights from the talks, outstanding issues along with plans and proposals for future work are briefly described in this report.

  18. Design and Analysis of a Micro-Optical Position Readout for Acceleration Sensing

    Energy Technology Data Exchange (ETDEWEB)

    Dickey, Fred M.; Holswade, Scott C.; Shagam, Richard N.

    1999-07-08

    Sandia National Laboratories is developing a MEMS-based trajectory safety subsystem, which allows enablement of critical functions only after a particular acceleration environment has been achieved. The device, known as an Environmental Sensing Device (ESD), consists of a suspended moving shuttle that translates a given distance when exposed to an appropriate acceleration environment. The shuttle contains an embedded code, consisting of grating structures, that is illuminated and optically read using a semiconductor laser and detector integrated together in a GaAs-based Photonic Integrated Circuit (PIC) flip-chip bonded to the assembly. This paper will describe the optical design and performance analysis of the embedded code features in the shuttle.

  19. Experimental evaluation of the Battelle accelerated test design for the solar array at Mead, Nebraska

    Energy Technology Data Exchange (ETDEWEB)

    Frickland, P.O.; Repar, J.

    1982-04-06

    A previously developed test design for accelerated aging of photovoltaic modules was experimentally evaluated. The studies included a review of relevant field experience, environmental chamber cycling of full-size modules, and electrical and physical evaluation of the effects of accelerated aging during and after the tests. The test results indicated that thermally induced fatigue of the interconnects was the primary mode of module failure as measured by normalized power output. No chemical change in the silicone encapsulant was detectable after 360 test cycles.

  20. Consequences of bounds on longitudinal emittance growth for the design of recirculating linear accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.

    2015-05-03

    Recirculating linear accelerators (RLAs) are a cost-effective method for the acceleration of muons for a muon collider in energy ranges from a couple GeV to a few 10s of GeV. Muon beams generally have longitudinal emittances that are large for the RF frequency that is used, and it is important to limit the growth of that longitudinal emittance. This has particular consequences for the arc design of the RLAs. I estimate the longitudinal emittance growth in an RLA arising from the RF nonlinearity. Given an emittance growth limitation and other design parameters, one can then compute the maximum momentum compaction in the arcs. I describe how to obtain an approximate arc design satisfying these requirements based on the deisgn in [1]. Longitudinal dynamics also determine the energy spread in the beam, and this has consequences on the transverse phase advance in the linac. This in turn has consequences for the arc design due to the need to match beta functions. I combine these considerations to discuss design parameters for the acceleration of muons for a collider in an RLA from 5 to 63 GeV.

  1. Preliminary Conceptual Design Report for the FACET-II Project at SLAC National Accelerator Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Hogan, Mark [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-04-22

    Plasma wakefield acceleration has the potential to dramatically shrink the size and cost of particle accelerators. Research at the SLAC National Accelerator Laboratory has demonstrated that plasmas can provide 1,000 times the acceleration in a given distance compared with current technologies. Developing revolutionary and more efficient acceleration techniques that allow for an affordable high-energy collider is the focus of FACET, a National User Facility at SLAC. The existing FACET National User Facility uses part of SLAC’s two-mile-long linear accelerator to generate high-density beams of electrons and positrons. FACET-II is a new test facility to develop advanced acceleration and coherent radiation techniques with high-energy electron and positron beams. It is the only facility in the world with high energy positron beams. FACET-II provides a major upgrade over current FACET capabilities and the breadth of the potential research program makes it truly unique. It will synergistically pursue accelerator science that is vital to the future of both advanced acceleration techniques for High Energy Physics, ultra-high brightness beams for Basic Energy Science, and novel radiation sources for a wide variety of applications. The design parameters for FACET-II are set by the requirements of the plasma wakefield experimental program. To drive the plasma wakefield requires a high peak current, in excess of 10kA. To reach this peak current, the electron and positron design bunch size is 10μ by 10μ transversely with a bunch length of 10μ. This is more than 200 times better than what has been achieved at the existing FACET. The beam energy is 10 GeV, set by the Linac length available and the repetition rate is up to 30 Hz. The FACET-II project is scheduled to be constructed in three major stages. Components of the project discussed in detail include the following: electron injector, bunch compressors and linac, the positron system, the Sector 20 sailboat and W chicanes

  2. Overview of the Beam diagnostics in the Medaustron Accelerator:Design choices and test Beam commissioning

    CERN Document Server

    Osmic, F; Gyorgy, A; Kerschbaum, A; Repovz, M; Schwarz, S; Neustadt, W; Burtin, G

    2012-01-01

    The MedAustron centre is a synchrotron based accelerator complex for cancer treatment and clinical and non-clinical research with protons and light ions, currently under construction in Wiener Neustadt, Austria. The accelerator complex is based on the CERN-PIMMS study [1] and its technical implementation by the Italian CNAO foundation in Pavia [2]. The MedAustron beam diagnostics system is based on sixteen different monitor types (153 devices in total) and will allow measuring all relevant beam parameters from the source to the irradiation rooms. The monitors will have to cope with large intensities and energy ranges. Currently, one ion source, the low energy beam transfer line and the RFQ are being commissioned in the Injector Test Stand (ITS) at CERN. This paper gives an overview of all beam monitors foreseen for the MedAustron accelerator, elaborates some of the design choices and reports the first beam commissioning results from the ITS.

  3. Design and realization of a high productivity cluster-based network application reconfigurable accelerator board

    Institute of Scientific and Technical Information of China (English)

    Zeng Yu; Li Jun; Sun Ninghui; Wang Jie; Liu Zhaohui

    2008-01-01

    Improving processor frequency to strengthen massive data processing capability will lead to incremental server marginal costs and bring about a series of problems such as power consumption, management complexity, etc. Based on the field programmable gate array (FPGA), TCP offload engine (TOE), zero-copy and other key technologies, this paper describes the design and realization of a reconfigurable accelerator board. In this board, TCP/IP protocol will be moved to high-speed reconfigurable accelerator board. The packets will be labeled according to the protocol and submitted to the upper data processing software after IP-quintuple filtering in hardware. Reconfigurable accelerator board obtains higher performance speed-up compared with ordinary NIC card.

  4. The international linear collider. Technical design report. Vol. 3.2. Accelerator baseline design

    International Nuclear Information System (INIS)

    The following topics are dealt with: General parameters with layout and systems overview, main linac and SCRF technology, electron source, damping rings, ring to main linac, beam delivery system and machine detector interface, global accelerator control systems, availability with commissioning and operations, conventional facilities and siting, possible upgrade and staging options, project implementation planning, construction schedule, ILC TDR value estimate. (HSI)

  5. DEVELOPING THE PHYSICS DESIGN FOR NDCX-II, A UNIQUE PULSE-COMPRESSING ION ACCELERATOR

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, A.; Barnard, J. J.; Cohen, R. H.; Grote, D. P.; Lund, S. M.; Sharp, W. M.; Faltens, A.; Henestroza, E.; Jung, J-Y.; Kwan, J. W.; Lee, E. P.; Leitner, M. A.; Logan, B. G.; Vay, J.-L.; Waldron, W. L.; Davidson, R.C.; Dorf, M.; Gilson, E.P.; Kaganovich, I.

    2009-07-20

    The Heavy Ion Fusion Science Virtual National Laboratory(a collaboration of LBNL, LLNL, and PPPL) is using intense ion beams to heat thin foils to the"warm dense matter" regime at<~;; 1 eV, and is developing capabilities for studying target physics relevant to ion-driven inertial fusion energy. The need for rapid target heating led to the development of plasma-neutralized pulse compression, with current amplification factors exceeding 50 now routine on the Neutralized Drift Compression Experiment (NDCX). Construction of an improved platform, NDCX-II, has begun at LBNL with planned completion in 2012. Using refurbished induction cells from the Advanced Test Accelerator at LLNL, NDCX-II will compress a ~;;500 ns pulse of Li+ ions to ~;;1 ns while accelerating it to 3-4 MeV over ~;;15 m. Strong space charge forces are incorporated into the machine design at a fundamental level. We are using analysis, an interactive 1D PIC code (ASP) with optimizing capabilities and centroid tracking, and multi-dimensional Warpcode PIC simulations, to develop the NDCX-II accelerator. This paper describes the computational models employed, and the resulting physics design for the accelerator.

  6. A conceptual design of the DTL-SDTL for the JAERI high intensity proton accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Ino, Hiroshi; Kabeya, Zenzaburo [Mitsubishi Heavy Industries Ltd., Tokyo (Japan); Chishiro, Etsuji; Ouchi, Nobuo; Hasegawa, Kazuo; Mizumoto, Motoharu

    1998-08-01

    A high intensity proton linear accelerator with an energy of 1.5 GeV and an average beam power of 8 MW has been proposed for the Neutron Science Project (NSP) at JAERI. This linac starts with radio-frequency quadrupole (RFQ) linac, which is followed by a drift-tube linac (DTL), separated-type DTL (SDTL), and a superconducting structure. In this report, we focus on the DTL and SDTL part of the accelerator. The DTL accelerates the beam from 2 to 51 MeV, and SDTL accelerates the beam from 51 to 10 MeV. Since the main features of the requirement for the DTL-SDTL are high peak current ({approx}30 mA) and a high-duty factor ({approx}CW), the conceptual design should be determined not only based on the result of a beam-dynamics calculation, but by careful study of the cooling problems. The design processes of the DTL-SDTL and the matching sections (RFQ to DTL, CW-Pulse merge section, and SDTL to SCC) and the result of a heat transfer analysis of DTL are described. (author)

  7. Design of a choke-mode damped accelerating structure for CLIC Main LINAC

    CERN Document Server

    Shi, J; Grudiev, A; Wuensch, W; Tang, C; Chen, H; Huang, W

    2011-01-01

    Choke-mode damped accelerating structures are being studied as an alternative to the baseline structure of the compact linear collider (CLIC) by a CERN-Tsinghua collaboration. Choke-mode structures hold the potential for much lower levels of pulsed surface heating and, since milling is not needed, reduced cost. Structures with radial choke attached are simulated in GdfidL to investigate the damping of the transverse wake. The first pass-band of the dipole modes is well damped, while the higher order dipole modes are possibly reflected by the choke. Therefore, the geometry of the choke is tuned to minimize the reflection of these higher order dipole modes. Based on this damping scheme, an accelerating structure with the same iris dimensions as the nominal CLIC design but with choke-mode damping has been designed. A prototype structure will be manufactured and high power tested in the near future.

  8. Present status of the Bevalac and design outline of proposed medical accelerator

    International Nuclear Information System (INIS)

    The Bevalac currently supports a strong and diverse program of scientific research with beams of relativistic heavy ions in the Biomedical and Nuclear Sciences. These programs utilize ions throughout the Periodic Table that range in energy from a few MeV to 2 GeV/nucleon, including radioactive secondary beams, such as neon-19. This paper first provides a brief overview of the Bevalac, its present operational status and the accelerator improvement program, followed by a rationale for the proposed construction of a hospital-based modern synchrotron dedicated to applications in Biomedicine, including the radiotherapeutic treatment of cancer and other human disorders. An outline of the proposed design for the new machine is given, including discussion of the design philosophy, a review of major accelerator components, and the expected performance and operating characteristics

  9. Design of a low-cost, compact SRF accelerator for flue gas and wastewater treatment

    Energy Technology Data Exchange (ETDEWEB)

    Ciovati, Gianluigi [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-04-01

    Funding is being requested pursuant to a proposal that was submitted and reviewed through the Portfolio Analysis and Management System (PAMS). PAMS Proposal ID: 222439. The proposed project consists of the design of a novel superconducting continuous-wave accelerator capable of providing a beam current of ~1 A at an energy of 1-2 MeV for the treatment of flue gases and wastewater streams. The novel approach consists on studying the feasibility of using a single-cell Nb cavity coated with a thin Nb3Sn layer of the inner surface and conductively cooled by to 4.2 K by cryocoolers inside a compact cryomodule. The proposed study will include beam transport simulations, thermal and mechanical engineering analysis of the cryomodule and a cost analysis for both the fabrications costs and the operational and maintenance costs of such accelerator. The outcome of the project will be a report summarizing the analysis and results from the design study.

  10. Reliability of home CPAP titration with different automatic CPAP devices

    Directory of Open Access Journals (Sweden)

    Lacasse Yves

    2008-07-01

    Full Text Available Abstract Background CPAP titration may be completed by automatic apparatus. However, differences in pressure behaviour could interfere with the reliability of pressure recommendations. Our objective was to compare pressure behaviour and effective pressure recommendations between three Automatic CPAP machines (Autoset Spirit, Remstar Auto, GK 420. Methods Sixteen untreated obstructive sleep apnea patients were randomly allocated to one of the 3 tested machines for a one-week home titration trial in a crossover design with a 10 days washout period between trials. Results The median pressure value was significantly lower with machine GK 420 (5.9 +/- 1.8 cm H2O than with the other devices both after one night and one week of CPAP titration (7.4 +/- 1.3 and 6.6 +/- 1.9 cm H2O. The maximal pressure obtained over the one-week titration was significantly higher with Remstar Auto (12.6 +/- 2.4 cm H2O, Mean +/- SD than with the two other ones (10.9 +/- 1.0 and 11.0 +/- 2.4 cm H2O. The variance in pressure recommendation significantly differed between the three machines after one night and between Autoset Spirit and the two other machines after 1 week. Conclusion Pressure behaviour and pressure recommendation significantly differ between Auto CPAP machines both after one night and one week of home titration.

  11. Complexometric titrations: new reagents and concepts to overcome old limitations.

    Science.gov (United States)

    Zhai, Jingying; Bakker, Eric

    2016-07-21

    Chelators and end point indicators are the most important parts of complexometric titrations. The most widely used universal chelator ethylenediamine tetraacetic acid (EDTA) and its derivatives can strongly coordinate with different metal ions. Their limited selectivity often requires the use of masking agents, and the multiple pKa values of the chelators necessitate a careful adjustment of pH during the procedure. Real world requirements for pH independent, selective and sensitive chelators and indicators call for a new design of these reagents. New concepts and structures of chelators and indicators have indeed recently emerged. We present here recent developments on chelators and indicators for complexometric titrations. Many of these advances were made possible only recently by moving the titration from a homogeneous to a heterogeneous phase using a new class of chelators and indicators based on highly selective ionophores embedded in ion-selective nanosphere emulsions. In view of achieving titrations in situ by complete instrumental control, thin layer electrochemistry has recently been shown to be an attractive concept that replaces the traditional cumbersome titration protocol with a direct reagent free sensing tool. PMID:27272695

  12. Medical linear accelerator mounted mini-beam collimator: design, fabrication and dosimetric characterization

    International Nuclear Information System (INIS)

    The goal of this work was to design, build and experimentally characterize a linear accelerator mounted mini-beam collimator for use at a nominal 6 MV beam energy. Monte Carlo simulation was used in the design and dosimetric characterization of a compact mini-beam collimator assembly mounted to a medical linear accelerator. After fabrication, experimental mini-beam dose profiles and central axis relative output were measured and the results used to validate the simulation data. The simulation data was then used to establish traceability back to an established dosimetric code of practice. The Monte Carlo simulation work revealed that changes in collimator blade width have a greater influence on the valley-to-peak dose ratio than do changes in blade height. There was good agreement between the modeled and measured profile data, with the exception of small differences on either side of the central peak dose. These differences were found to be systematic across all depths and result from limitations associated with the collimator fabrication. Experimental mini-beam relative output and simulation data agreed to better than  ±2.0%, which is well within the level of uncertainty required for dosimetric traceability of non-standard field geometries. A mini-beam collimator has now been designed, built and experimentally characterized for use with a commercial linear accelerator operated at a nominal 6 MV beam energy. (paper)

  13. Methodology for the structural design of single spoke accelerating cavities at Fermilab

    Science.gov (United States)

    Passarelli, Donato; Wands, Robert H.; Merio, Margherita; Ristori, Leonardo

    2016-10-01

    Fermilab is planning to upgrade its accelerator complex to deliver a more powerful and intense proton-beam for neutrino experiments. In the framework of the so-called Proton Improvement Plan-II (PIP-II), we are designing and developing a cryomodule containing superconducting accelerating cavities, the Single Spoke Resonators of type 1 (SSR1). In this paper, we present the sequence of analysis and calculations performed for the structural design of these cavities, using the rules of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (BPVC). The lack of an accepted procedure for addressing the design, fabrication, and inspection of such unique pressure vessels makes the task demanding and challenging every time. Several factors such as exotic materials, unqualified brazing procedures, limited nondestructive examination, and the general R&D nature of these early generations of cavity design, conspire to make it impractical to obtain full compliance with all ASME BPVC requirements. However, the presented approach allowed us to validate the design of this new generation of single spoke cavities with values of maximum allowable working pressure that exceeds the safety requirements. This set of rules could be used as a starting point for the structural design and development of similar objects.

  14. DESIGN CONSIDERATIONS OF FAST KICKER SYSTEMS FOR HIGH INTENSITY PROTON ACCELERATORS

    International Nuclear Information System (INIS)

    In this paper, we discuss the specific issues related to the design of the Fast Kicker Systems for high intensity proton accelerators. To address these issues in the preliminary design stage can be critical since the fast kicker systems affect the machine lattice structure and overall design parameters. Main topics include system architecture, design strategy, beam current coupling, grounding, end user cost vs. system cost, reliability, redundancy and flexibility. Operating experience with the Alternating Gradient Synchrotron injection and extraction kicker systems at Brookhaven National Laboratory and their future upgrade is presented. Additionally, new conceptual designs of the extraction kicker for the Spallation Neutron Source at Oak Ridge and the Advanced Hydrotest Facility at Los Alamos are discussed

  15. A Laser-Pointer-Based Spectrometer for Endpoint Detection of EDTA Titrations

    Science.gov (United States)

    Dahm, Christopher E.; Hall, James W.; Mattioni, Brian E.

    2004-01-01

    A laser spectrometer for the ethylenediaminetetra-acetic acid (EDTA) titration of magnesium or calcium ions that is designed around a handheld laser pointer as the source and a photoresistor as the detector is developed. Findings show that the use of the spectrometer reduces the degree of uncertainty and error in one part of the EDTA titrations,…

  16. Electromagnetic Design of RF Cavities for Accelerating Low-Energy Muons

    Energy Technology Data Exchange (ETDEWEB)

    Kurennoy, Sergey S. [Los Alamos National Laboratory

    2012-05-14

    A high-gradient linear accelerator for accelerating low-energy muons and pions in a strong solenoidal magnetic field has been proposed for homeland defense and industrial applications. The acceleration starts immediately after collection of pions from a target in a solenoidal magnetic field and brings decay muons, which initially have kinetic energies mostly around 15-20 MeV, to 200 MeV over a distance of {approx}10 m. At this energy, both ionization cooling and further, more conventional acceleration of the muon beam become feasible. A normal-conducting linac with external-solenoid focusing can provide the required large beam acceptances. The linac consists of independently fed zero-mode (TM{sub 010}) RF cavities with wide beam apertures closed by thin conducting edge-cooled windows. Electromagnetic design of the cavity, including its RF coupler, tuning and vacuum elements, and field probes, has been developed with the CST MicroWave Studio, and is presented.

  17. Physics design of a CW high-power proton Linac for accelerator-driven system

    Indian Academy of Sciences (India)

    Rajni Pande; Shweta Roy; S V L S Rao; P Singh; S Kailas

    2012-02-01

    Accelerator-driven systems (ADS) have evoked lot of interest the world over because of their capability to incinerate the MA (minor actinides) and LLFP (long-lived fission products) radiotoxic waste and their ability to utilize thorium as an alternative nuclear fuel. One of the main subsystems of ADS is a high energy (∼1 GeV) and high current (∼30 mA) CW proton Linac. The accelerator for ADS should have high efficiency and reliability and very low beam losses to allow hands-on maintenance. With these criteria, the beam dynamics simulations for a 1 GeV, 30 mA proton Linac has been done. The Linac consists of normal-conducting radio-frequency quadrupole (RFQ), drift tube linac (DTL) and coupled cavity drift tube Linac (CCDTL) structures that accelerate the beam to about 100 MeV followed by superconducting (SC) elliptical cavities, which accelerate the beam from 100 MeV to 1 GeV. The details of the design are presented in this paper.

  18. Design, fabrication and testing of a large cylindrical vacuum vessel for proton linear accelerator

    International Nuclear Information System (INIS)

    The paper deals with engineering design, fabrication, copper plating and vacuum design and leak testing of the first prototype segment of Alveraz type drift tube Proton Linear Accelerator (DTL) being developed at CAT. The prototype drift tube linac segment is a long horizontal cylindrical vacuum vessel. The cylindrical cavity is internally machined and copper plated from inside and operates at 202 MHz (RF) with a vacuum better than 1 x 10-6 mbar. There are 34 openings provided for vacuum pumps, RF input and monitoring loops, piston tuners etc. and a large openings for insertions of drift tubes from top of the tank. (author)

  19. Coupled Mechanical-Electrochemical-Thermal Modeling for Accelerated Design of EV Batteries

    Energy Technology Data Exchange (ETDEWEB)

    Santhanagopalan, Shriram; Zhang, Chao; Kim, Gi-Heon; Pesaran, Ahmad A.

    2015-05-03

    This presentation provides an overview of the mechanical electrochemical-thermal (M-ECT) modeling efforts. The physical phenomena occurring in a battery are many and complex and operate at different scales (particle, electrodes, cell, and pack). A better understanding of the interplay between different physics occurring at different scales through modeling could provide insight to design improved batteries for electric vehicles. Work funded by the U.S. DOE has resulted in development of computer-aided engineering (CAE) tools to accelerate electrochemical and thermal design of batteries; mechanical modeling is under way. Three competitive CAE tools are now commercially available.

  20. Design, construction and installation of the electromechanical components of the current control of filament of the Pelletron Electron Accelerator

    International Nuclear Information System (INIS)

    For the operation of the Pelletron electron accelerator is required to have control of the filament current. For it was designed, built and installed an electromechanical system located in the Acceleration Unit inside the Accelerator tank and operated from the Control console. All the components located inside the tank operated under the following conditions: Pressure: until 7.03 Kg/cm2; High voltage: 106 V (only the insulating arrow); Atmosphere: mixture of N2 and CO2 or SF6. (Author)

  1. Accelerator-based conversion (ABC) of weapons plutonium: Plant layout study and related design issues

    International Nuclear Information System (INIS)

    In preparation for and in support of a detailed R and D Plan for the Accelerator-Based Conversion (ABC) of weapons plutonium, an ABC Plant Layout Study was conducted at the level of a pre-conceptual engineering design. The plant layout is based on an adaptation of the Molten-Salt Breeder Reactor (MSBR) detailed conceptual design that was completed in the early 1070s. Although the ABC Plant Layout Study included the Accelerator Equipment as an essential element, the engineering assessment focused primarily on the Target; Primary System (blanket and all systems containing plutonium-bearing fuel salt); the Heat-Removal System (secondary-coolant-salt and supercritical-steam systems); Chemical Processing; Operation and Maintenance; Containment and Safety; and Instrumentation and Control systems. Although constrained primarily to a reflection of an accelerator-driven (subcritical) variant of MSBR system, unique features and added flexibilities of the ABC suggest improved or alternative approaches to each of the above-listed subsystems; these, along with the key technical issues in need of resolution through a detailed R ampersand D plan for ABC are described on the bases of the ''strawman'' or ''point-of-departure'' plant layout that resulted from this study

  2. Sulfur hexafluoride reprocessing system design for a large pulsed power accelerator

    International Nuclear Information System (INIS)

    The Particle Beam Fusion Accelerator-II (PBFA-II) is a large, high power accelerator being constructed at Sandia National Labs to conduct research in inertial confinement fusion. One key to the success of this machine is the ability to produce an electrical pulse at the target with a well defined shape (power versus time). This requires that the 36 electrical drivers be initiated with good simultaneity. Simultaneity (or jitter) of the 36 module shot outputs is controlled by a sequence of pulse outputs starting at the control/monitor input to the trigger amplifier and then to the Marx trigger generators, the Marx generators, and finally the rimfire switches. A homogeneous insulating vapor in these switches is thought to reduce the jitter; however, actual data are not available to establish this concept. PBFA-II uses sulfur hexafluoride (SF6) for this insulating vapor. This paper describes the requirements placed on an SF6 reprocessing system when operating in a fusion research accelerator, resulting in criteria used to design the reprocessing system, and the subsequent design implemented to meet these criteria

  3. A COMMON COIL DESIGN FOR HIGH FIELD 2 IN 1 ACCELERATOR MAGNETS.

    Energy Technology Data Exchange (ETDEWEB)

    GUPTA,R.

    2002-05-12

    A common coil design concept for 2-in-1 superconducting accelerator magnets is presented. It practically eliminates the major problems in the ends of high field magnets built with either high temperature superconductors (HTS) or conventional superconductors. Racetrack coils, consisting of rectangular blocks built with either superconducting tapes or cables, are common to both apertures with each aperture containing one half of each coil. The ends are easy to wind with the conductors experiencing little strain. The overall magnet design, construction and tooling are also expected to be simpler than in the conventional cosine theta magnets. The concept is also suitable for superferric and combined function magnet designs. A modular design for an HTS based R&D magnet is also presented.

  4. Client Server design and implementation issues in the Accelerator Control System environment

    International Nuclear Information System (INIS)

    In distributed system communication software design, the Client Server model has been widely used. This paper addresses the design and implementation issues of such a model, particularly when used in Accelerator Control Systems. in designing the Client Server model one needs to decide how the services will be defined for a server, what types of messages the server will respond to, which data formats will be used for the network transactions and how the server will be located by the client. Special consideration needs to be given to error handling both on the server and client side. Since the server usually is located on a machine other than the client, easy and informative server diagnostic capability is required. The higher level abstraction provided by the Client Server model simplifies the application writing, however fine control over network parameters is essential to improve the performance. Above mentioned design issues and implementation trade-offs are discussed in this paper

  5. Recruitment Maneuvers and PEEP Titration.

    Science.gov (United States)

    Hess, Dean R

    2015-11-01

    The injurious effects of alveolar overdistention are well accepted, and there is little debate regarding the importance of pressure and volume limitation during mechanical ventilation. The role of recruitment maneuvers is more controversial. Alveolar recruitment is desirable if it can be achieved, but the potential for recruitment is variable among patients with ARDS. A stepwise recruitment maneuver, similar to an incremental PEEP titration, is favored over sustained inflation recruitment maneuvers. Many approaches to PEEP titration have been proposed, and the best method to choose the most appropriate level for an individual patient is unclear. A PEEP level should be selected that balances alveolar recruitment against overdistention. The easiest approach to select PEEP might be according to the severity of the disease: 5-10 cm H2O PEEP in mild ARDS, 10-15 cm H2O PEEP in moderate ARDS, and 15-20 cm H2O PEEP in severe ARDS. Recruitment maneuvers and PEEP should be used within the context of lung protection and not just as a means of improving oxygenation. PMID:26493593

  6. Accelerator-driven system design concept for disposing of spent nuclear fuels

    International Nuclear Information System (INIS)

    At present, the US SNF (Spent Nuclear Fuel) inventory is growing by about 2,000 metric tonnes (MT) per year from the current operating nuclear power plants to reach about 70,000 MT by 2015. This SNF inventory contains about 1% transuranics (700 MT), which has about 115 MT of minor actinides. Accelerator-driven systems utilising proton accelerators with neutron spallation targets and subcritical blankets can be utilised for transmuting these transuranics, simultaneously generating carbon free energy, and significantly reducing the capacity of the required geological repository storage facility for the spent nuclear fuels. A fraction of the SNF plutonium can be used as a MOX fuel in the current/future thermal power reactors and as a starting fuel for future fast power reactors. The uranium of the spent nuclear fuel can be recycled for use in future nuclear power plants. This paper shows that only four to five accelerator-driven systems operating for less than 33 full power years can dispose of the US SNF inventory expected by 2015. In addition, a significant fraction of the long-lived fission products will be transmuted at the same time. Each system consists of a proton accelerator with a neutron spallation target and a subcritical assembly. The accelerator beam parameters are 1 GeV protons and 25 MW beam power, which produce 3 GWt in the subcritical assembly. A liquid metal (lead or lead-bismuth eutectic) spallation target is selected because of design advantages. This target is located at the centre of the subcritical assembly to maximise the utilisation of spallation neutrons. Because of the high power density in the target material, the target has its own coolant loop, which is independent of the subcritical assembly coolant loop. Mobile fuel forms with transuranic materials without uranium are considered in this work with liquid lead or lead-bismuth eutectic as fuel carrier

  7. Power System Design Compromises for Large-Scale Linear Particle Accelerators

    CERN Document Server

    Papastergiou, K D

    2014-01-01

    This paper discusses various design aspects of a 280MW Power System for the Compact Linear Collider (CLIC), a 50km long electrons-positrons accelerator, under feasibility evaluation. The key requirements are a very high accelerator availability and constant power flow from the utility grid, considering the pulsed power nature of CLIC. Firstly, the possible power network and cabling layouts are discussed along with potential difficulties on electrical fault clearance. Following, the use of active front-end converters is examined as a means to control the power flow and power quality seen by the 400kV grid. In particular a modular multilevel converter preliminary configuration is described and the compromises related to energy storage and voltage level are discussed.

  8. Power supply design for the filament of the high-voltage electron accelerator

    Science.gov (United States)

    Zhang, Lige; Yang, Lei; Yang, Jun; Huang, Jiang; Liu, Kaifeng; Zuo, Chen

    2015-12-01

    The filament is a key component for the electron emission in the high-voltage electron accelerator. In order to guarantee the stability of the beam intensity and ensure the proper functioning for the power supply in the airtight steel barrel, an efficient filament power supply under accurate control is required. The paper, based on the dual-switch forward converter and synchronous rectification technology, puts forward a prototype of power supply design for the filament of the high-voltage accelerator. The simulation is conducted with MATLAB-Simulink on the main topology and the control method. Loss analysis and thermal analysis are evaluated using the FEA method. Tests show that in this prototype, the accuracy of current control is higher than 97.5%, and the efficiency of the power supply reaches 87.8% when the output current is 40 A.

  9. LAVENDER: A steady-state core analysis code for design studies of accelerator driven subcritical reactors

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Shengcheng; Wu, Hongchun; Cao, Liangzhi; Zheng, Youqi, E-mail: yqzheng@mail.xjtu.edu.cn; Huang, Kai; He, Mingtao; Li, Xunzhao

    2014-10-15

    Highlights: • A new code system for design studies of accelerator driven subcritical reactors (ADSRs) is developed. • S{sub N} transport solver in triangular-z meshes, fine deletion analysis and multi-channel thermal-hydraulics analysis are coupled in the code. • Numerical results indicate that the code is reliable and efficient for design studies of ADSRs. - Abstract: Accelerator driven subcritical reactors (ADSRs) have been proposed and widely investigated for the transmutation of transuranics (TRUs). ADSRs have several special characteristics, such as the subcritical core driven by spallation neutrons, anisotropic neutron flux distribution and complex geometry etc. These bring up requirements for development or extension of analysis codes to perform design studies. A code system named LAVENDER has been developed in this paper. It couples the modules for spallation target simulation and subcritical core analysis. The neutron transport-depletion calculation scheme is used based on the homogenized cross section from assembly calculations. A three-dimensional S{sub N} nodal transport code based on triangular-z meshes is employed and a multi-channel thermal-hydraulics analysis model is integrated. In the depletion calculation, the evolution of isotopic composition in the core is evaluated using the transmutation trajectory analysis algorithm (TTA) and fine depletion chains. The new code is verified by several benchmarks and code-to-code comparisons. Numerical results indicate that LAVENDER is reliable and efficient to be applied for the steady-state analysis and reactor core design of ADSRs.

  10. Experimental design and analysis for accelerated degradation tests with Li-ion cells.

    Energy Technology Data Exchange (ETDEWEB)

    Doughty, Daniel Harvey; Thomas, Edward Victor; Jungst, Rudolph George; Roth, Emanuel Peter

    2003-08-01

    This document describes a general protocol (involving both experimental and data analytic aspects) that is designed to be a roadmap for rapidly obtaining a useful assessment of the average lifetime (at some specified use conditions) that might be expected from cells of a particular design. The proposed experimental protocol involves a series of accelerated degradation experiments. Through the acquisition of degradation data over time specified by the experimental protocol, an unambiguous assessment of the effects of accelerating factors (e.g., temperature and state of charge) on various measures of the health of a cell (e.g., power fade and capacity fade) will result. In order to assess cell lifetime, it is necessary to develop a model that accurately predicts degradation over a range of the experimental factors. In general, it is difficult to specify an appropriate model form without some preliminary analysis of the data. Nevertheless, assuming that the aging phenomenon relates to a chemical reaction with simple first-order rate kinetics, a data analysis protocol is also provided to construct a useful model that relates performance degradation to the levels of the accelerating factors. This model can then be used to make an accurate assessment of the average cell lifetime. The proposed experimental and data analysis protocols are illustrated with a case study involving the effects of accelerated aging on the power output from Gen-2 cells. For this case study, inadequacies of the simple first-order kinetics model were observed. However, a more complex model allowing for the effects of two concurrent mechanisms provided an accurate representation of the experimental data.

  11. Target/Blanket Design for the Accelerator Production of Tritium Plant

    International Nuclear Information System (INIS)

    The Accelerator Production of Tritium Target/Blanket (T/B) system is comprised of an assembly of tritium-producing modules supported by safety, heat removal, shielding, and retargeting systems. The T/B assembly produces tritium using a high-energy proton beam, a tungsten/lead spallation neutron source and 3He gas as the tritium-producing feedstock. The supporting heat removal systems remove the heat deposited by the proton beam during both normal and off-normal conditions. The shielding protects workers from ionizing radiation, and the retargeting systems remove and replace components that have reached their end of life. All systems reside within the T/B building, which is located at the end of a linear accelerator. For the nominal production mode, protons are accelerated to an energy of 1030 MeV at a current of 100 mA and are directed onto the T/B assembly. The protons are expanded to a 0.19- x 1.9-m beam spot before striking a centrally located tungsten neutron source. A surrounding lead blanket produces additional neutrons from scattered high-energy particles. A total of 27 neutrons are produced per incident proton. Tritium is produced by neutron capture in 3He gas that is contained in aluminum tubes throughout the blanket. The 3He/tritium mixture is removed on a semi-continuous basis for purification in an adjacent Tritium Separation Facility. Systems and components are designed with safety as a primary consideration to minimize risk to the workers and the public. Materials and component designs were chosen based on the experiences of operating spallation neutron sources that have been designed and built for the neutron science community. An extensive engineering development and demonstration program provides detailed information for the completion of the design

  12. Risks and benefits of rapid clozapine titration

    Directory of Open Access Journals (Sweden)

    Jeannie D. Lochhead

    2016-05-01

    Full Text Available Clozapine is often considered the gold standard for the treatment of schizophrenia. Clinical guidelines suggest a gradual titration over 2 weeks to reduce the risks of adverse events such as seizures, hypotension, agranulocytosis, and myocarditis. The slow titration often delays time to therapeutic response. This raises the question of whether, in some patients, it may be safe to use a more rapid clozapine titration. The following case illustrates the potential risks associated with the use of multiple antipsychotics and rapid clozapine titration. We present the case of a young man with schizophrenia who developed life threatening neuroleptic malignant syndrome (NMS during rapid clozapine titration and treatment with multiple antipsychotics. We were unable to find another case in the literature of NMS associated with rapid clozapine titration. This case is meant to urge clinicians to carefully evaluate the risks and benefits of rapid clozapine titration, and to encourage researchers to further evaluate the safety of rapid clozapine titration. Rapid clozapine titration has implications for decreasing health care costs associated with prolonged hospitalizations, and decreasing the emotional suffering associated with uncontrolled symptoms of psychosis. Clozapine is considered the most effective antipsychotic available thus efforts should focus on developing strategies that would allow for safest and most efficient use of clozapine to encourage its utilization for treatment resistance schizophrenia.

  13. Klystron Modulator Design for the Los Alamos Neutron Science Center Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Reass, William A. [Los Alamos National Laboratory; Baca, David M. [Los Alamos National Laboratory; Partridge, Edward R. [retired; Rees, Daniel E. [Los Alamos National Laboratory

    2012-06-22

    This paper will describe the design of the 44 modulator systems that will be installed to upgrade the Los Alamos Neutron Science Center (LANSCE) accelerator RF system. The klystrons can operate up to 86 kV with a nominal 32 Amp beam current with a 120 Hz repetition rate and 15% duty cycle. The klystrons are a mod-anode design. The modulator is designed with analog feedback control to ensure the klystron beam current is flat-top regulated. To achieve fast switching while maintaining linear feedback control, a grid-clamp, totem-pole modulator configuration is used with an 'on' deck and an 'off' deck. The on and off deck modulators are of identical design and utilize a cascode connected planar triode, cathode driven with a high speed MOSFET. The derived feedback is connected to the planar triode grid to enable the flat-top control. Although modern design approaches suggest solid state designs may be considered, the planar triode (Eimac Y-847B) is very cost effective, is easy to integrate with the existing hardware, and provides a simplified linear feedback control mechanism. The design is very compact and fault tolerant. This paper will review the complete electrical design, operational performance, and system characterization as applied to the LANSCE installation.

  14. Design of a 50 MW 30 GHz gyroklystron amplifier for accelerator applications

    CERN Document Server

    Blank, M; Cauffman, S; Felch, K; Mizuhara, Y M; Lawson, W

    2002-01-01

    Summary form only given. The results of a study performed by CPI for CERN are described below. The purpose of the work was to design a pulsed 30 GHz, 50 MW gyroklystron amplifier to be used for testing and conditioning Compact Linear Collider (CLIC) mainline accelerating structures. The specifications for the amplifier are listed. The technical risk factors and achievable performance for several distinct configurations, including coaxial and cylindrical cavities interacting at the fundamental and second harmonic of the cyclotron frequency, were investigated in the study. Following detailed physics designs of several different circuits and electron guns, a fundamental TE/sub 011/ coaxial mode configuration was selected as the most likely to achieve the specifications. Design details and performance predictions for this configuration are given.

  15. Design, development and analysis of high voltage, high frequency transformer for dc accelerator application

    International Nuclear Information System (INIS)

    This paper covers the design, development and analysis of High Voltage, High Frequency Transformer for DC Accelerator application. Distributed capacitance, leakage inductance, skin effect and HV Insulation are major design challenges for this type of Transformer. A prototype of 30 kV - 0 - 30 kV, 10 kHz, 500 W output power, Ferrite Core Transformer have been designed, fabricated and tested. Spice simulations have been done for estimating transformer parameters. Effect of high frequency and requirement of HV Insulation have been studied and analyzed. The effects of Magnetic Core behaviour and its losses have been studied. Based on study and test result, distributed capacitance, leakage inductance, and Transformer scheme has been optimized for 30 kV - 0 - 30 kV, 10 kHz, 10 kW output power. (author)

  16. Solving Large Scale Nonlinear Eigenvalue Problem in Next-Generation Accelerator Design

    Energy Technology Data Exchange (ETDEWEB)

    Liao, Ben-Shan; Bai, Zhaojun; /UC, Davis; Lee, Lie-Quan; Ko, Kwok; /SLAC

    2006-09-28

    A number of numerical methods, including inverse iteration, method of successive linear problem and nonlinear Arnoldi algorithm, are studied in this paper to solve a large scale nonlinear eigenvalue problem arising from finite element analysis of resonant frequencies and external Q{sub e} values of a waveguide loaded cavity in the next-generation accelerator design. They present a nonlinear Rayleigh-Ritz iterative projection algorithm, NRRIT in short and demonstrate that it is the most promising approach for a model scale cavity design. The NRRIT algorithm is an extension of the nonlinear Arnoldi algorithm due to Voss. Computational challenges of solving such a nonlinear eigenvalue problem for a full scale cavity design are outlined.

  17. Design of a Normal Acceleration and Angle of Attack Control System for a Missile Having Front and Rear Control Surfaces

    Science.gov (United States)

    Ochi, Yoshimasa

    Precise normal acceleration control is essential for missile guidance. Missiles with both front and rear control surfaces have a higher ability to control normal acceleration than missiles with front or rear control surfaces only. From the viewpoint of control, however, the control problem becomes a two-input-one-output problem, where generally control input cannot be determined uniquely. This paper proposes controlling angle of attack as well as normal acceleration, which makes the problem a two-input-two-output one and determines the controls uniquely. Normal acceleration command is given by a guidance system, but angle of attack command must be generated in accordance to the acceleration command without affecting the normal acceleration control. This paper also proposes such a command generator for angle of attack. Computer simulation is conducted using a nonlinear missile model to investigate the effectiveness of the control system along with control systems designed using three other methods.

  18. Facility for Advanced Accelerator Experimental Tests at SLAC (FACET) Conceptual Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Amann, J.; Bane, K.; /SLAC

    2009-10-30

    This Conceptual Design Report (CDR) describes the design of FACET. It will be updated to stay current with the developing design of the facility. This CDR begins as the baseline conceptual design and will evolve into an 'as-built' manual for the completed facility. The Executive Summary, Chapter 1, gives an introduction to the FACET project and describes the salient features of its design. Chapter 2 gives an overview of FACET. It describes the general parameters of the machine and the basic approaches to implementation. The FACET project does not include the implementation of specific scientific experiments either for plasma wake-field acceleration for other applications. Nonetheless, enough work has been done to define potential experiments to assure that the facility can meet the requirements of the experimental community. Chapter 3, Scientific Case, describes the planned plasma wakefield and other experiments. Chapter 4, Technical Description of FACET, describes the parameters and design of all technical systems of FACET. FACET uses the first two thirds of the existing SLAC linac to accelerate the beam to about 20GeV, and compress it with the aid of two chicanes, located in Sector 10 and Sector 20. The Sector 20 area will include a focusing system, the generic experimental area and the beam dump. Chapter 5, Management of Scientific Program, describes the management of the scientific program at FACET. Chapter 6, Environment, Safety and Health and Quality Assurance, describes the existing programs at SLAC and their application to the FACET project. It includes a preliminary analysis of safety hazards and the planned mitigation. Chapter 7, Work Breakdown Structure, describes the structure used for developing the cost estimates, which will also be used to manage the project. The chapter defines the scope of work of each element down to level 3.

  19. Proceedings of the WAMSDO 2013 Workshop on Accelerator Magnet, Superconductor, Design and Optimization, CERN Geneva, Switzerland, 15 - 16 Jan 2013

    OpenAIRE

    Todesco, E.

    2014-01-01

    This report contains the proceedings of the Workshop on Accelerator Magnet Superconductor, Design and Optimization (WAMSDO) held at CERN from 15 to 16 January 2013. This fourth edition of the WAMSDO workshop is focussed on aspects related to quench protection.

  20. Lattice design of the integrable optics test accelerator and optical stochastic cooling experiment at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Kafka, Gene [Illinois Inst. of Technology, Chicago, IL (United States)

    2015-05-01

    The Integrable Optics Test Accelerator (IOTA) storage ring at Fermilab will serve as the backbone for a broad spectrum of Advanced Accelerator R&D (AARD) experiments, and as such, must be designed with signi cant exibility in mind, but without compromising cost e ciency. The nonlinear experiments at IOTA will include: achievement of a large nonlinear tune shift/spread without degradation of dynamic aperture; suppression of strong lattice resonances; study of stability of nonlinear systems to perturbations; and studies of di erent variants of nonlinear magnet design. The ring optics control has challenging requirements that reach or exceed the present state of the art. The development of a complete self-consistent design of the IOTA ring optics, meeting the demands of all planned AARD experiments, is presented. Of particular interest are the precise control for nonlinear integrable optics experiments and the transverse-to-longitudinal coupling and phase stability for the Optical Stochastic Cooling Experiment (OSC). Since the beam time-of- ight must be tightly controlled in the OSC section, studies of second order corrections in this section are presented.

  1. Accelerating Design of Batteries Using Computer-Aided Engineering Tools (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A.; Kim, G. H.; Smith, K.

    2010-11-01

    Computer-aided engineering (CAE) is a proven pathway, especially in the automotive industry, to improve performance by resolving the relevant physics in complex systems, shortening the product development design cycle, thus reducing cost, and providing an efficient way to evaluate parameters for robust designs. Academic models include the relevant physics details, but neglect engineering complexities. Industry models include the relevant macroscopic geometry and system conditions, but simplify the fundamental physics too much. Most of the CAE battery tools for in-house use are custom model codes and require expert users. There is a need to make these battery modeling and design tools more accessible to end users such as battery developers, pack integrators, and vehicle makers. Developing integrated and physics-based CAE battery tools can reduce the design, build, test, break, re-design, re-build, and re-test cycle and help lower costs. NREL has been involved in developing various models to predict the thermal and electrochemical performance of large-format cells and has used in commercial three-dimensional finite-element analysis and computational fluid dynamics to study battery pack thermal issues. These NREL cell and pack design tools can be integrated to help support the automotive industry and to accelerate battery design.

  2. Nap-titration : An effective alternative for continuous positive airway pressure titration

    NARCIS (Netherlands)

    Hoekema, A; Stegenga, B; Meinesz, AF; van der Hoeven, JH; Wijkstra, PJ

    2006-01-01

    When treating Obstructive Steep Apnea-Hypopnea Syndrome (OSAHS) several alternatives for standard (manual) continuous positive airway pressure (CPAP) titration are feasible. A practical alternative is titration without polysomnography during an afternoon nap (Nap-titration). The aim of the present s

  3. Beam dynamics design of the main accelerating section with KONUS in the CSR-LINAC

    CERN Document Server

    Xiao-Hu, Zhang; Jia-Wen, Xia; Xue-Jun, Yin; Heng, Du

    2013-01-01

    The CSR-LINAC injector has been proposed in Heavy Ion Research Facility in Lanzhou (HIRFL). The linac mainly consists of two parts, the RFQ and the IH-DTL. The KONUS (Kombinierte Null Grad Struktur) concept has been introduced into the DTL section. In this paper, the re-matching of the main accelerating section will be finished in the 3.7 MeV/u scheme and the new beam dynamics design up to 7 MeV/u will be also shown. Through the beam re-matching, the relative emittance growth has been suppressed greatly along the linac.

  4. Design, simulation and construction of quadrupole magnets for focusing electron beam in powerful industrial electron accelerator

    OpenAIRE

    S KH Mousavi; A M Poursaleh; S Haseltalab; M Mortazavi; A Behjat; Atefi, M.

    2015-01-01

    In this paper the design and simulation of quadrupole magnets and electron beam optical of that by CST Studio code has been studied. Based on simulation result the magnetic quadrupole has been done for using in beam line of first Iranian powerful electron accelerator. For making the suitable magnetic field the effects of material and core geometry and coils current variation on quadrupole magnetic field have been studied. For test of quadrupole magnet the 10 MeV beam energy and 0.5 pi mm...

  5. Design of 10 GeV laser wakefield accelerator stages with shaped laser modes

    Energy Technology Data Exchange (ETDEWEB)

    Cormier-Michel, Estelle; Esarey, E.; Geddes, C.G.R.; Geddes, C.G.R.; Leemans, W.P.; Bruhwiler, D.L.; Cowan, B.; Paul, K.

    2009-09-25

    We present particle-in-cell simulations, using the VORPAL framework, of 10 GeV laser plasma wakefield accelerator stages. Scaling of the physical parameters with the plasma density allows us to perform these simulations at reasonable cost and to design high performance stages. In particular we show that, by choosing to operate in the quasi-linear regime, we can use higher order laser modes to tailor the focusing forces. This makes it possible to increase the matched electron beam radius and hence the total charge in the bunch while preserving the low bunch emittance required for applications.

  6. Proposed New Accelerator Design for Homeland Security X-Ray Applications

    Science.gov (United States)

    Clayton, James; Shedlock, Daniel; Langeveld, Willem G. J.; Bharadwaj, Vinod; Nosochkov, Yuri

    Two goals for security scanning of cargo and freight are the ability to determine the type of material that is being imaged, and to do so at low radiation dose. One commonly used technique to determine the effective Z of the cargo is dual-energy imaging, i.e. imaging with different x-ray energy spectra. Another technique uses the fact that the transmitted x-ray spectrum itself also depends on the effective Z. Spectroscopy is difficult because the energy of individual x rays needs to be measured in a very high count-rate environment. Typical accelerators for security applications offer large but short bursts of x-rays, suitable for current-mode integrated imaging. In order to perform x-ray spectroscopy, a new accelerator design is desired that has the following features: 1)increased duty factor in order to spread out the arrival of x-rays at the detector array over time; 2)x-ray intensitymodulation from one delivered pulse to the next by adjusting the accelerator electron beam instantaneous current so as to deliveradequate signal without saturating the spectroscopic detector; and 3)the capability to direct the (forward peaked) x-ray intensity towards high-attenuation areas in the cargo ("fan-beam-steering"). Current sources are capable of 0.1% duty factor, although usually they are operated at significantly lower duty factors (∼0.04%), but duty factors in the range 0.4-1.0% are desired. The higher duty factor can be accomplished, e.g., by moving from 300 pulses per second (pps) to 1000 pps and/or increasing the pulse duration from a typical 4 μs to 10 μs. This paper describes initial R&D to examine cost effective modifications that could be performed on a typical accelerator for these purposes, as well as R&D for fan-beam steering.

  7. Improving the design and analysis of superconducting magnets for particle accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, R C [Univ. of Rajasthan, Jaipur (India). Dept. of Physics

    1996-11-01

    High energy particle accelerators are now the primary means of discovering the basic building blocks of matter and understanding the forces between them. In order to minimize the cost of building these machines, superconducting magnets are used in essentially all present day high energy proton and heavy ion colliders. The cost of superconducting magnets is typically in the range of 20--30% of the total cost of building such machines. The circulating particle beam goes through these magnets a large number of times (over hundreds of millions). The luminosity performance and life time of the beam in these machines depends significantly on the field quality in these magnets. Therefore, even a small error in the magnetic field shape may create a large cumulative effect in the beam trajectory to throw the particles of the magnet aperture. The superconducting accelerator magnets must, therefore, be designed and constructed so that these errors are small. In this thesis the research and development work will be described 3which has resulted in significant improvements in the field quality of the superconducting magnets for the Relativistic Heavy Ion Collider (RHIC). The design and the field quality improvements in the prototype of the main collider dipole magnet for the Superconducting Super Collider (SSC) will also be presented. RHIC will accelerate and collide two counter rotating beams of heavy ions up to 100 GeV/u and protons up to 250 GeV. It is expected that RHIC will create a hot, dense quark-gluon plasma and the conditions which, according to the Big Bang theory, existed in the early universe.

  8. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    Science.gov (United States)

    Gencer, A.; Demirköz, B.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-07-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between 10 μA and 1.2 mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam flux. The DBL is designed to provide fluxes between 107 p /cm2 / s and 109 p /cm2 / s for performing irradiation tests in an area of 15.4 cm × 21.5 cm. The facility will be the first irradiation facility of its kind in Turkey.

  9. Design of incentive programs for accelerating penetration of energy-efficient appliances

    International Nuclear Information System (INIS)

    Incentives are policy tools that sway purchase, retail stocking, and production decisions toward energy-efficient products. Incentives complement mandatory standards and labeling policies by accelerating market penetration of products that are more energy efficient than required by existing standards and by preparing the market for more stringent future mandatory requirements. Incentives can be directed at different points in the appliance's supply chain; one point may be more effective than another depending on the technology's maturity and market penetration. This paper seeks to inform future policy and program design by categorizing the main elements of incentive programs from around the world. We identify advantages and disadvantages of program designs through a qualitative overview of incentive programs worldwide. We find that financial incentive programs have greater impact when they target highly efficient technologies with a small market share, and that program designs depend on the market barriers addressed, the target equipment, and the local market context. No program design is inherently superior to another. The key to successful program design and implementation is a thorough understanding of the market and identification of the most important local obstacles to the penetration of energy-efficient technologies. - Highlights: • We researched incentive programs design and implementation worldwide. • This paper seeks to inform future policy and program design. • We identify design and identify advantages and disadvantages. • We find that incentive programs have greater impact when they target highly efficient products. • Program designs depend on the market barriers addressed and the local market context

  10. Proposed New Accelerator Design for Homeland Security X-Ray Applications

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, James [Varian Medical Systems, Inc., Palo Alto, CA 94304 (United States). Imaging Lab.; Shedlock, Daniel [Varian Medical Systems, Inc., Palo Alto, CA 94304 (United States). Imaging Lab.; Langeveld, Willem G.J. [Rapiscan Laboratories, Inc., Sunnyvale, CA 94085 (United States); Bharadwaj, Vinod [SLAC National Accelerator Lab., Menlo Park, CA (United States); Nosochkov, Yuri [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-07

    In the security and inspection market, there is a push towards highly mobile, reduced-dose active interrogation scanning and imaging systems to allow operation in urban environments. To achieve these goals, the accelerator system design needs to be smaller than existing systems. A smaller radiation exclusion zone may be accomplished through better beam collimation and an integrated, x-ray-source/detector-array assembly to allow feedback and control of an intensity-modulated x-ray source. A shaped low-Z target in the x-ray source can be used to generate a more forward peaked x-ray beam. Electron-beam steering can then be applied to direct the forward-peaked x rays toward areas in the cargo with high attenuation. This paper presents an exploratory study to identify components and upgrades that would be required to meet the desired specifications, as well as the best technical approach to design and build a prototype.

  11. Design of CEBAF's [Continuous Electron Beam Accelerator Facility] rf separator and results of cold tests

    International Nuclear Information System (INIS)

    The design of the CEBAF accelerator system is based upon a multipass racetrack configuration, the straight sections of which will utilize 1497-MHz superconducting linac sections with independent magnetic transport at the end of each linac segment. Room temperature SW rf separators operating at a frequency of 998 MHz will be used in each independent transport channel at one end of the racetrack to extract a portion of the recirculating current. With the frequency chosen and appropriate phasing, three independent beams of correlated energy may be extracted for use in the three experimental areas. The design of the rf separators, abased on an alternating periodic structure (APS), will be described and some preliminary prototype cold test results will be given. 11 refs., 10 figs., 2 tabs

  12. Test Results of a Superconducting Quadrupole Model Designed for Linear Accelerator Applications

    Energy Technology Data Exchange (ETDEWEB)

    Kashikhin, Vladimir S.; Andreev, Nikolai; Chlachidze, Guram; DiMarco, Joseph; Kashikhin, Vadim V.; Lamm, Michael J.; Lopes, Mauricio L.; Orris, Darryl; Tartaglia, Michael; Tompkins, John C.; Velev, Gueorgui; /Fermilab

    2008-08-01

    The first model of a superconducting quadrupole for use in a Linear Accelerator was designed, built and tested at Fermilab. The quadrupole has a 78 mm aperture, and a cold mass length of 680 mm. A superferric magnet configuration with iron poles and four racetrack coils was chosen based on magnet performance, cost, and reliability considerations. Each coil is wound using enamel insulated, 0.5 mm diameter, NbTi superconductor. The quadrupole package also includes racetrack type dipole steering coils. The results of the quadrupole design, manufacturing and test, are presented. Specific issues related to the quadrupole magnetic center stability, superconductor magnetization and mechanical stability are discussed. The magnet quench performance and results of magnetic measurements will also be briefly discussed.

  13. Beam Transfer Line Design for a Plasma Wakefield Acceleration Experiment (AWAKE) at the CERN SPS

    CERN Document Server

    Bracco, C; Brethoux, D; Clerc, V; Goddard, B; Gschwendtner, E; Jensen, L K; Kosmicki, A; Le Godec, G; Meddahi, M; Muggli, P; Mutin, C; Osborne, O; Papastergiou, K; Pardons, A; Velotti, F M; Vincke, H

    2013-01-01

    The world’s first proton driven plasma wakefield acceleration experiment (AWAKE) is presently being studied at CERN. The experimentwill use a high energy proton beam extracted from the SPS as driver. Two possible locations for installing the AWAKE facility were considered: the West Area and the CNGS beam line. The previous transfer line from the SPS to the West Area was completely dismantled in 2005 and would need to be fully re-designed and re-built. For this option, geometric constraints for radiation protection reasons would limit the maximum proton beam energy to 300 GeV. The existing CNGS line could be used by applying only minor changes to the lattice for the final focusing and the interface between the proton beam and the laser, required for plasma ionisation and bunch-modulation seeding. The beam line design studies performed for the two options are presented.

  14. The design of a simulated in-line side-coupled 6 MV linear accelerator waveguide

    International Nuclear Information System (INIS)

    Purpose: The design of a 3D in-line side-coupled 6 MV linac waveguide for medical use is given, and the effect of the side-coupling and port irises on the radio frequency (RF), beam dynamics, and dosimetric solutions is examined. This work was motivated by our research on a linac-MR hybrid system, where accurate electron trajectory information for a clinical medical waveguide in the presence of an external magnetic field was needed. Methods: For this work, the design of the linac waveguide was generated using the finite element method. The design outlined here incorporates the necessary geometric changes needed to incorporate a full-end accelerating cavity with a single-coupling iris, a waveguide-cavity coupling port iris that allows power transfer into the waveguide from the magnetron, as well as a method to control the RF field magnitude within the first half accelerating cavity into which the electrons from the gun are injected. Results: With the full waveguide designed to resonate at 2998.5±0.1 MHz, a full 3D RF field solution was obtained. The accuracy of the 3D RF field solution was estimated through a comparison of important linac parameters (Q factor, shunt impedance, transit time factor, and resonant frequency) calculated for one accelerating cavity with the benchmarked program SUPERFISH. It was found that the maximum difference between the 3D solution and SUPERFISH was less than 0.03%. The eigenvalue solver, which determines the resonant frequencies of the 3D side-coupled waveguide simulation, was shown to be highly accurate through a comparison with lumped circuit theory. Two different waveguide geometries were examined, one incorporating a 0.5 mm first side cavity shift and another with a 1.5 mm first side cavity shift. The asymmetrically placed side-coupling irises and the port iris for both models were shown to introduce asymmetries in the RF field large enough to cause a peak shift and skewing (center of gravity minus peak shift) of an initially

  15. Design of APhF-IH Linac for a Compact Medical Accelerator

    CERN Document Server

    Kapin, V; Iwata, Y

    2003-01-01

    The design of a small injection linac for a compact medical synchrotron is discussed. The linac design is based on interdigital H-type (IH) drift-tube structure with alternative phase focusing (APhF). A high acceleration rate and an absence of magnetic lenses inside drift-tubes reduce the cost and length of APhF-IH linac in comparison with HIMAC linac based on Alvarez structure with magnet quadrupoles inside drift-tubes. To reduce effects of emittance growth, the RFQ structure is used in front of the APhF linac. In such linac layout, the current transmission of a carbon beam can reach up to 90-100%. In this report, the basic parameters of whole linac are presented, while the design of APhF structure is considered in details. Two reference designs of 4 MeV/u 200 MHz APhF linacs with different voltage distributions along the whole tank have been generated and analyzed numerically. For the first design, a constant voltage distribution along the tank is assumed. The total length of the structure is about 4.2 m. F...

  16. Surface Titrations of Perlite Suspensions.

    Science.gov (United States)

    Alkan; Do

    1998-11-01

    The surface charge behaviour of unexpanded and expanded perlite samples in KNO3 and NaCl solutions were investigated as a function of pH and ionic strength. The solutions of KNO3 and NaCl ranging from 10(-3) to 1.0 M were used. The potentiometric titration method was used to determine the surface charge of perlite samples. It was confirmed that the perlite samples had no the point of zero charge and was negatively charged in the pH range of 3-10. The double extrapolation method was used for determining the intrinsic equilibrium constants for simple ionization and complex ionization reactions. The values obtained are pKinta2 = 2.5 and p*KintK+ = 2.3 in KNO3 solutions and pKinta2 = 3.0 and p*KintNa+ = 2.4 in NaCl solutions for unexpanded perlite, and pKinta2 = 2.6 and p*KintK+ = 2.4 in KNO3 solutions and pKinta2 = 2.7 and pKintNa+ = 2.4 in NaCl solutions for expanded perlite. Copyright 1998 Academic Press.

  17. Design study for a high-current, steady-state autoresonant accelerator. Final report, July 14-November 14, 1979

    International Nuclear Information System (INIS)

    During the past year and a half, both theoretical and engineering investigations have been carried forward in a research program to assess the feasibility, and provide conceptual designs and engineering design studies for high current, steady state Auto-Resonant Accelerators. The behavior of each of the various components of an Auto-Resonant Accelerator has been carefully examined for the case of moderately relativistic electron energy and high electron current which will be appropriate for steady state operation. In general, a very considerable amount of progress has been achieved on the front-end components of the accelerator, with design options narrowed significantly and preliminary design parameters even determined for the power supplies, the electron beam source, the radiation shielding, the convergent Pierce gun diode, and the electron cyclotron wave exciter. For the downstream accelerator components consisting of the gas cell and electrode structures which are used to generate and load the ions into the cyclotron wave and to eliminate secondary electrons, conceptual designs have been realized; however, some further work remains to be done before an optimized engineering design of these components can be constructed for a first experimental test of a steady state Auto-Resonant Accelerator

  18. Design and construction of the clean room for proton beam accelerator assembly

    International Nuclear Information System (INIS)

    The objective of this report is to design, construction and evaluation of clean room for proton beam accelerator assembly. The design conditions o Class : 1,000(1,000 ea ft3), o Flow Rate : 200 m3/h m2, o Temperature : 22 deg C±2, o Humidity : 55%±5. The main design results are summarized as follows: o Air-handling unit : Cooling Capacity : 13,500 kcal/h, Heating Capacity : 10,300 kcal/h, Humidity Capacity : 4 kg/h, Flow Rate : 150 CMM o Air Shower : Flow Rate : 35 CMM, Size : 1500 x 1000 x 2200, Material : In-steel, Out-SUS304, Filter : PRE + HEPA, AIR Velocity : 25 m/s o Relief Damper : Size : Φ250, Casing : SS41, Blade : AL, Shaft : SUS304, Weight Ring : SS41, Grill : AL o HEPA Filter Box : Filter Box Size : 670 x 670 x 630, Filter Size : 610 x 610 x 150, Frame: Poly Wood, Media : Glass Fiber, Filter Efficiency : 0.3μm, 99.97%, Separator : AL, Flow Rate : 17 CMM, Damper Size : Φ300 Following this report will be used important data for the design, construction, operation and maintenance of the clean room, for high precision apparatus assembly laboratory

  19. Determination of titratable acidity in white wine

    Directory of Open Access Journals (Sweden)

    Rajković Miloš B.

    2007-01-01

    Full Text Available The amount of titration acid in must is in the largest number of cases with in the range 5.0-8.0 g/dm3. Wines, as a rule, contain less acids than must, and according to Regulations, titratable acidity is in the range of 4.0-8.0 g/dm3 expressed in tartaric acid, because a part of tartaric acid is deposited in the form of salts (tartar or argol during alcohol fermentation. For wines that contain less than 4 g/dm3 of titratable acids there arises a suspicion about their origin, that is, that during the preparation some illegal acts were done. Because of that, the aim of this paper is to determine titratable acidity in white wine, using standard methods of determination, which are compared with the results received by potentiometric titration using ion-selective electrode. According to the received results it can be seen that wine titration with indicator gives sufficient reliable values of wine titration acidity. However, as potentiometric titration at pH value 7.00 is more reliable and objective method, the values of titratable acids content in wine, expressed through tartaric acid, are given according to this result. The analysis of differential potentiometric curves shows that these curves can give us an answer to the question of the presence of a larger amount of other nonorganic substances, which have already existed in wine. However, none of the used methods gives absolutely reliable answer what substances are present in analysed samples.

  20. Designer Micelles Accelerate Flux Through Engineered Metabolism in E. coli and Support Biocompatible Chemistry.

    Science.gov (United States)

    Wallace, Stephen; Balskus, Emily P

    2016-05-10

    Synthetic biology has enabled the production of many value-added chemicals via microbial fermentation. However, the problem of low product titers from recombinant pathways has limited the utility of this approach. Methods to increase metabolic flux are therefore critical to the success of metabolic engineering. Here we demonstrate that vitamin E-derived designer micelles, originally developed for use in synthetic chemistry, are biocompatible and accelerate flux through a styrene production pathway in Escherichia coli. We show that these micelles associate non-covalently with the bacterial outer-membrane and that this interaction increases membrane permeability. In addition, these micelles also accommodate both heterogeneous and organic-soluble transition metal catalysts and accelerate biocompatible cyclopropanation in vivo. Overall, this work demonstrates that these surfactants hold great promise for further application in the field of synthetic biotechnology, and for expanding the types of molecules that can be readily accessed from renewable resources via the combination of microbial fermentation and biocompatible chemistry. PMID:27061024

  1. Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chunlong; Qi, Jiahui; Tao, Jinhui; Zuckermann, Ronald; De Yoreo, James J.

    2014-09-05

    In nature, proteins play a significant role in biomineral formation. One of the ultimate goals of bioinspired materials science is to develop highly stable synthetic molecules that mimic the function of these natural proteins by controlling crystal formation. Here, we demonstrate that both the morphology and the degree of acceleration or inhibition observed during growth of calcite in the presence of peptoids can be rationally tuned by balancing the electrostatic interactions (EI) and hydrophobic interactions (HI), with HI playing the dominant role. While either strong EI or HI inhibit growth and suppress (104) face expression, correlations between peptoid-crystal binding energies and observed changes in calcite growth indicate moderate EI allow peptoids to weakly adsorb while moderate HI cause disruption of surface-adsorbed water layers, leading to growth acceleration with retained expression of (104) faces. This study provides fundamental principles for designing peptoids as crystallization promoters, and offers a straightforward screening method based on macroscopic crystal morphology. Because peptoids are sequence-specific, highly stable, and easily synthesized, peptoid-enhanced crystallization offers a broad range of potential applications.

  2. Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics

    Science.gov (United States)

    Chen, Chun-Long; Qi, Jiahui; Tao, Jinhui; Zuckermann, Ronald N.; Deyoreo, James J.

    2014-09-01

    In nature, proteins play a significant role in biomineral formation. One of the ultimate goals of bioinspired materials science is to develop highly stable synthetic molecules that mimic the function of these natural proteins by controlling crystal formation. Here, we demonstrate that both the morphology and the degree of acceleration or inhibition observed during growth of calcite in the presence of peptoids can be rationally tuned by balancing the electrostatic and hydrophobic interactions, with hydrophobic interactions playing the dominant role. While either strong electrostatic or hydrophobic interactions inhibit growth and reduces expression of the {104} faces, correlations between peptoid-crystal binding energies and observed changes in calcite growth indicate moderate electrostatic interactions allow peptoids to weakly adsorb while moderate hydrophobic interactions cause disruption of surface-adsorbed water layers, leading to growth acceleration with retained expression of the {104} faces. This study provides fundamental principles for designing peptoids as crystallization promoters, and offers a straightforward screening method based on macroscopic crystal morphology. Because peptoids are sequence-specific, highly stable, and easily synthesized, peptoid-enhanced crystallization offers a broad range of potential applications.

  3. Operational Radiation Protection in High-Energy Physics Accelerators: Implementation of ALARA in Design and Operation of Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Fasso, A.; Rokni, S.; /SLAC

    2011-06-30

    It used to happen often, to us accelerator radiation protection staff, to be asked by a new radiation worker: ?How much dose am I still allowed?? And we smiled looking at the shocked reaction to our answer: ?You are not allowed any dose?. Nowadays, also thanks to improved training programs, this kind of question has become less frequent, but it is still not always easy to convince workers that staying below the exposure limits is not sufficient. After all, radiation is still the only harmful agent for which this is true: for all other risks in everyday life, from road speed limits to concentration of hazardous chemicals in air and water, compliance to regulations is ensured by keeping below a certain value. It appears that a tendency is starting to develop to extend the radiation approach to other pollutants (1), but it will take some time before the new attitude makes it way into national legislations.

  4. Methodology to improve design of accelerated life tests in civil engineering projects.

    Directory of Open Access Journals (Sweden)

    Jing Lin

    Full Text Available For reliability testing an Energy Expansion Tree (EET and a companion Energy Function Model (EFM are proposed and described in this paper. Different from conventional approaches, the EET provides a more comprehensive and objective way to systematically identify external energy factors affecting reliability. The EFM introduces energy loss into a traditional Function Model to identify internal energy sources affecting reliability. The combination creates a sound way to enumerate the energies to which a system may be exposed during its lifetime. We input these energies into planning an accelerated life test, a Multi Environment Over Stress Test. The test objective is to discover weak links and interactions among the system and the energies to which it is exposed, and design them out. As an example, the methods are applied to the pipe in subsea pipeline. However, they can be widely used in other civil engineering industries as well. The proposed method is compared with current methods.

  5. Design, simulation and construction of quadrupole magnets for focusing electron beam in powerful industrial electron accelerator

    Directory of Open Access Journals (Sweden)

    S KH Mousavi

    2015-09-01

    Full Text Available In this paper the design and simulation of quadrupole magnets and electron beam optical of that by CST Studio code has been studied. Based on simulation result the magnetic quadrupole has been done for using in beam line of first Iranian powerful electron accelerator. For making the suitable magnetic field the effects of material and core geometry and coils current variation on quadrupole magnetic field have been studied. For test of quadrupole magnet the 10 MeV beam energy and 0.5 pi mm mrad emittance of input beam has been considered. We see the electron beam through the quadrupole magnet focus in one side and defocus in other side. The optimum of distance between two quadrupole magnets for low emittance have been achieved. The simulation results have good agreement with experimental results

  6. Methodology to improve design of accelerated life tests in civil engineering projects.

    Science.gov (United States)

    Lin, Jing; Yuan, Yongbo; Zhou, Jilai; Gao, Jie

    2014-01-01

    For reliability testing an Energy Expansion Tree (EET) and a companion Energy Function Model (EFM) are proposed and described in this paper. Different from conventional approaches, the EET provides a more comprehensive and objective way to systematically identify external energy factors affecting reliability. The EFM introduces energy loss into a traditional Function Model to identify internal energy sources affecting reliability. The combination creates a sound way to enumerate the energies to which a system may be exposed during its lifetime. We input these energies into planning an accelerated life test, a Multi Environment Over Stress Test. The test objective is to discover weak links and interactions among the system and the energies to which it is exposed, and design them out. As an example, the methods are applied to the pipe in subsea pipeline. However, they can be widely used in other civil engineering industries as well. The proposed method is compared with current methods.

  7. Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science.

    Science.gov (United States)

    Guerette, Paul A; Hoon, Shawn; Seow, Yiqi; Raida, Manfred; Masic, Admir; Wong, Fong T; Ho, Vincent H B; Kong, Kiat Whye; Demirel, Melik C; Pena-Francesch, Abdon; Amini, Shahrouz; Tay, Gavin Z; Ding, Dawei; Miserez, Ali

    2013-10-01

    Efforts to engineer new materials inspired by biological structures are hampered by the lack of genomic data from many model organisms studied in biomimetic research. Here we show that biomimetic engineering can be accelerated by integrating high-throughput RNA-seq with proteomics and advanced materials characterization. This approach can be applied to a broad range of systems, as we illustrate by investigating diverse high-performance biological materials involved in embryo protection, adhesion and predation. In one example, we rapidly engineer recombinant squid sucker ring teeth proteins into a range of structural and functional materials, including nanopatterned surfaces and photo-cross-linked films that exceed the mechanical properties of most natural and synthetic polymers. Integrating RNA-seq with proteomics and materials science facilitates the molecular characterization of natural materials and the effective translation of their molecular designs into a wide range of bio-inspired materials.

  8. AGS SUPER NEUTRINO BEAM FACILITY ACCELERATOR AND TARGET SYSTEM DESIGN (NEUTRINO WORKING GROUP REPORT-II).

    Energy Technology Data Exchange (ETDEWEB)

    DIWAN,M.; MARCIANO,W.; WENG,W.; RAPARIA,D.

    2003-04-21

    This document describes the design of the accelerator and target systems for the AGS Super Neutrino Beam Facility. Under the direction of the Associate Laboratory Director Tom Kirk, BNL has established a Neutrino Working Group to explore the scientific case and facility requirements for a very long baseline neutrino experiment. Results of a study of the physics merit and detector performance was published in BNL-69395 in October 2002, where it was shown that a wide-band neutrino beam generated by a 1 MW proton beam from the AGS, coupled with a half megaton water Cerenkov detector located deep underground in the former Homestake mine in South Dakota would be able to measure the complete set of neutrino oscillation parameters: (1) precise determination of the oscillation parameters {Delta}m{sub 32}{sup 2} and sin{sup 2} 2{theta}{sub 32}; (2) detection of the oscillation of {nu}{sub {mu}}-{nu}{sub e} and measurement of sin{sup 2} 2{theta}{sub 13}; (3) measurement of {Delta}m{sub 21}{sup 2} sin 2{theta}{sub 12} in a {nu}{sub {mu}} {yields} {nu}{sub e} appearance mode, independent of the value of {theta}{sub 13}; (4) verification of matter enhancement and the sign of {Delta}m{sub 32}{sup 2}; and (5) determination of the CP-violation parameter {delta}{sub CP} in the neutrino sector. This report details the performance requirements and conceptual design of the accelerator and the target systems for the production of a neutrino beam by a 1.0 MW proton beam from the AGS. The major components of this facility include a new 1.2 GeV superconducting linac, ramping the AGS at 2.5 Hz, and the new target station for 1.0 MW beam. It also calls for moderate increase, about 30%, of the AGS intensity per pulse. Special care is taken to account for all sources of proton beam loss plus shielding and collimation of stray beam halo particles to ensure equipment reliability and personal safety. A preliminary cost estimate and schedule for the accelerator upgrade and target system are also

  9. The design of the electron beam dump unit of Turkish Accelerator Center (TAC)

    Science.gov (United States)

    Cite, L. H.; Yilmaz, M.

    2016-03-01

    The required simulations of the electron beam interactions for the design of electron beam dump unit for an accelerator which will operate to get two Infra-Red Free Electron Lasers (IR-FEL) covering the range of 3-250 microns is presented in this work. Simulations have been carried out to understand the interactions of a bulk of specially shaped of four different and widely used materials for the dump materials for a 77 pC, 40 MeV, 13 MHz repetition rate e-beam. In the simulation studies dump materials are chosen to absorb the 99% of the beam energy and to restrict the radio-isotope production in the bulk of the dump. A Lead shielding also designed around the dump core to prevent the leakage out of the all the emitted secondary radiations, e.g., neutrons, photons. The necessary dump material requirements, for the overall design considerations and the possible radiation originated effects on the dump unit, are discussed and presented.

  10. Magnetic and Structural Design of a 15 T $Nb_3Sn$ Accelerator Depole Model

    Energy Technology Data Exchange (ETDEWEB)

    Kashikhin, V. V. [Fermilab; Andreev, N. [Fermilab; Barzi, E. [Fermilab; Novitski, I. [Fermilab; Zlobin, A. V. [Fermilab

    2015-01-01

    Hadron Colliders (HC) are the most powerful discovery tools in modern high energy physics. A 100 TeV scale HC with a nominal operation field of at least 15 T is being considered for the post-LHC era. The choice of a 15 T nominal field requires using the Nb3Sn technology. Practical demonstration of this field level in an accelerator-quality magnet and substantial reduction of the magnet costs are the key conditions for realization of such a machine. FNAL has started the development of a 15 T $Nb_{3}Sn$ dipole demonstrator for a 100 TeV scale HC. The magnet design is based on 4-layer shell type coils, graded between the inner and outer layers to maximize the performance. The experience gained during the 11-T dipole R&D campaign is applied to different aspects of the magnet design. This paper describes the magnetic and structural designs and parameters of the 15 T $Nb_3Sn$ dipole and the steps towards the demonstration model.

  11. Present status and future needs of nuclear data for high energy accelerator shielding design calculation

    International Nuclear Information System (INIS)

    With increasing application of high energy accelerators, their shielding design study has become very important. The present study discusses the current status of nuclear data, especially inclusive neutron production cross sections (thin target yields), thick target yields, neutron transmission through shield and cross sections, and activation and spallation cross sections of neutrons and protons. Their experimental and theoretical data are compared and further needs of basic nuclear data for shielding design calculation are described. Nuclear data in high energy regions above 20 MeV, such as double differential neutron production cross section, double differential neutron yield and neutron reaction cross section, are very poor both in number and in accuracy at the present stage. The shielding design calculation requires the comprehensive data set of these cross sections and/or the more accurate computer code to calculate these quantities. Further effort is expected to carry out shielding and cross section experiments using the monoenergetic neutron beam line which is under construction in Takasaki Branch of JAERI (Japan Atomic Energy Research Institute). (N.K.)

  12. Natural Monocrystalline Pyrite as Sensor for Potentiometric Redox Titrations. Part I. Titrations with Permanganate

    OpenAIRE

    Vukanovic, B. V.; Mihajlovic, R. P.; Antonijevic, M. M.

    2002-01-01

    Results obtained in potentiometric titrations of Fe(II), Mn(II), Fe(CN)64-, C2O42- and As(III) with standard potassium permanganate solution, are presented. The titration end point (TEP) was detected with a universal electrode whose sensor is natural crystalline pyrite. The titrations of As(III) were carried out in HCl (1.2 M) and H2SO4 solutions (0.1- 4.5 M), whereas oxalate was determined in H2SO4 (0.1-4.5 M). Iron(II) and hexacyanoferrate(II) were titrated in H2SO4 and also in H3PO4 soluti...

  13. Beam Dynamics Studies and the Design, Fabrication and Testing of Superconducting Radiofrequency Cavity for High Intensity Proton Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Saini, Arun [Univ. of Delhi, New Delhi (India)

    2012-03-01

    The application horizon of particle accelerators has been widening significantly in recent decades. Where large accelerators have traditionally been the tools of the trade for high-energy nuclear and particle physics, applications in the last decade have grown to include large-scale accelerators like synchrotron light sources and spallation neutron sources. Applications like generation of rare isotopes, transmutation of nuclear reactor waste, sub-critical nuclear power, generation of neutrino beams etc. are next area of investigation for accelerator scientific community all over the world. Such applications require high beam power in the range of few mega-watts (MW). One such high intensity proton beam facility is proposed at Fermilab, Batavia, US, named as Project-X. Project-X facility is based on H- linear accelerator (linac), which will operate in continuous wave (CW) mode and accelerate H- ion beam with average current of 1 mA from kinetic energy of 2.5 MeV to 3 GeV to deliver 3MW beam power. One of the most challenging tasks of the Project-X facility is to have a robust design of the CW linac which can provide high quality beam to several experiments simultaneously. Hence a careful design of linac is important to achieve this objective.

  14. Conceptual design of a laser-plasma accelerator driven free-electron laser demonstration experiment

    International Nuclear Information System (INIS)

    Up to now, short-wavelength free-electron lasers (FEL) have been systems on the scale of hundreds of meters up to multiple kilometers. Due to the advancements in laser-plasma acceleration in the recent years, these accelerators have become a promising candidate for driving a fifth-generation synchrotron light source - a lab-scale free-electron laser. So far, demonstration experiments have been hindered by the broad energy spread typical for this type of accelerator. This thesis addresses the most important challenges of the conceptual design for a first lab-scale FEL demonstration experiment using analytical considerations as well as simulations. The broad energy spread reduces the FEL performance directly by weakening the microbunching and indirectly via chromatic emittance growth, caused by the focusing system. Both issues can be mitigated by decompressing the electron bunch in a magnetic chicane, resulting in a sorting by energies. This reduces the local energy spread as well as the local chromatic emittance growth and also lowers performance degradations caused by the short bunch length. Moreover, the energy dependent focus position leads to a focus motion within the bunch, which can be synchronized with the radiation pulse, maximizing the current density in the interaction region. This concept is termed chromatic focus matching. A comparison shows the advantages of the longitudinal decompression concept compared to the alternative approach of transverse dispersion. When using typical laser-plasma based electron bunches, coherent synchrotron radiation and space-charge contribute in equal measure to the emittance growth during decompression. It is shown that a chicane for this purpose must not be as weak and long as affordable to reduce coherent synchrotron radiation, but that an intermediate length is required. Furthermore, the interplay of the individual concepts and components is assessed in a start-to-end simulation, confirming the feasibility of the

  15. Thermal Design of an Nb3Sn High Field Accelerator Magnet

    CERN Document Server

    Pietrowicz, S

    2011-01-01

    Within the framework of the European project EuCARD, a Nb3Sn high field accelerator magnet is under design to serve as a test bed for future high field magnets and to upgrade the vertical CERN cable test facility, Fresca. The Fresca 2 block coil type magnet will be operated at 1.9 K or 4.2 K and is designed to produce about 13 T. A 2D numerical thermal model was developed to determinate the temperature margin of the coil in working conditions and the appropriate cool-down scenario. The temperature margin, which is DTmarge=5.8 K at 1.9 K and DTmarge=3.5 K at 4.2 K, was investigated in steady state condition with the AC losses due to field ramp rate as input heat generation. Several cool-down scenarios were examined in order to minimize the temperature difference and therefore reducing the mechanical constraints within the structure. The paper presents the numerical model, the assumptions taken for the calculations and several results of the simulation for the cool-down and temperature distributions due to seve...

  16. Preliminary neutronics design analysis on accelerator driven subcritical reactor for nuclear waste transmutation

    International Nuclear Information System (INIS)

    By taking minor actinides (MA) transmutation performance as evaluation index, preliminary neutronics design analyses were performed on ADS-NWT which is a lead-alloy cooled accelerator driven subcritical reactor for nuclear waste transmutation. In the specific design, liquid lead-bismuth eutectic (LBE) and transuranic metallic dispersion fuel were used as coolant and a fuel of ADS-NWT, respectively. The neutronics calculations and analyses were performed by using CAD-based multi-functional 4D neutronics and radiation simulation system named VisualBUS and the nuclear data library HENDL (Hybrid Evaluated Nuclear Data Library). The preliminary results showed that based on specific deign of MA/Pu volume ratio of 7 : 3, the transmutation rate of MA was approximately 650 kg/a, the high thermal reactor power output was ∼1000 MW when energy self-sustaining was satisfied and relatively deep subcriticality and negative reactivity coefficients made sure of good inherent safety of ADS-NWT. (authors)

  17. Design of a high average-power FEL driven by an existing 20 MV electrostatic-accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Kimel, I.; Elias, L.R. [Univ. of Central Florida, Orlando, FL (United States)

    1995-12-31

    There are some important applications where high average-power radiation is required. Two examples are industrial machining and space power-beaming. Unfortunately, up to date no FEL has been able to show more than 10 Watts of average power. To remedy this situation we started a program geared towards the development of high average-power FELs. As a first step we are building in our CREOL laboratory, a compact FEL which will generate close to 1 kW in CW operation. As the next step we are also engaged in the design of a much higher average-power system based on a 20 MV electrostatic accelerator. This FEL will be capable of operating CW with a power output of 60 kW. The idea is to perform a high power demonstration using the existing 20 MV electrostatic accelerator at the Tandar facility in Buenos Aires. This machine has been dedicated to accelerate heavy ions for experiments and applications in nuclear and atomic physics. The necessary adaptations required to utilize the machine to accelerate electrons will be described. An important aspect of the design of the 20 MV system, is the electron beam optics through almost 30 meters of accelerating and decelerating tubes as well as the undulator. Of equal importance is a careful design of the long resonator with mirrors able to withstand high power loading with proper heat dissipation features.

  18. Development of design technique for vacuum insulation in large size multi-aperture multi-grid accelerator for nuclear fusion

    Science.gov (United States)

    Kojima, A.; Hanada, M.; Tobari, H.; Nishikiori, R.; Hiratsuka, J.; Kashiwagi, M.; Umeda, N.; Yoshida, M.; Ichikawa, M.; Watanabe, K.; Yamano, Y.; Grisham, L. R.

    2016-02-01

    Design techniques for the vacuum insulation have been developed in order to realize a reliable voltage holding capability of multi-aperture multi-grid (MAMuG) accelerators for fusion application. In this method, the nested multi-stage configuration of the MAMuG accelerator can be uniquely designed to satisfy the target voltage within given boundary conditions. The evaluation of the voltage holding capabilities of each acceleration stages was based on the previous experimental results about the area effect and the multi-aperture effect. Since the multi-grid effect was found to be the extension of the area effect by the total facing area this time, the total voltage holding capability of the multi-stage can be estimated from that per single stage by assuming the stage with the highest electric field, the total facing area, and the total apertures. By applying these consideration, the analysis on the 3-stage MAMuG accelerator for JT-60SA agreed well with the past gap-scan experiments with an accuracy of less than 10% variation, which demonstrated the high reliability to design MAMuG accelerators and also multi-stage high voltage bushings.

  19. Plutonium titration by controlled potential coulometry

    International Nuclear Information System (INIS)

    The LAMMAN (Nuclear Materials Metrology Laboratory) is the support laboratory of the CETAMA (Analytical Method Committee), whose two main activities are developing analytic methods, and making and characterizing reference materials. The LAMMAN chose to develop the controlled potential coulometry because it is a very accurate analytical technique which allows the connection between the quantity of element electrolysed to the quantity of electricity measured thanks to the Faraday's law: it does not require the use of a chemical standard. This method was first used for the plutonium titration and was developed in the Materials Analysis and Metrology Laboratory (LAMM), for upgrading its performances and developing it to the titration of other actinides. The equipment and the material used were developed to allow the work in confined atmosphere (in a glove box), with all the restrictions involved. Plutonium standard solutions are used to qualify the method, and in particular to do titrations with an uncertainty better than 0.1 %. The present study allowed making a bibliographic research about controlled potential coulometry applied to the actinides (plutonium, uranium, neptunium, americium and curium). A full procedure was written to set all the steps of plutonium titration, from the preparation of samples to equipments storage. A method validation was done to check the full procedure, and the experimental conditions: working range, uncertainty, performance... Coulometric titration of the plutonium from pure solution (without interfering elements) was developed to the coulometric titration of the plutonium in presence of uranium, which allows to do accurate analyses for the analyses of some parts of the reprocessing of the spent nuclear fuel. The possibility of developing this method to other actinides than plutonium was highlighted thanks to voltammetric studies, like the coulometric titration of uranium with a working carbon electrode in sulphuric medium. (author)

  20. Study on design of superconducting proton linac for accelerator driven subcritical nuclear power system

    CERN Document Server

    Yu Qi; Xu Tao Guang

    2002-01-01

    As a prior option of the next generation of energy source, the accelerator driven subcritical nuclear power system (ADS) can use efficiently the uranium and thorium resource, transmute the high-level long-lived radioactive wastes and raise nuclear safety. The ADS accelerator should provide the proton beam with tens megawatts. The superconducting linac (SCL) is a good selection of ADS accelerator because of its high efficiency and low beam loss rate. It is constitute by a series of the superconducting accelerating cavities. The cavity geometry is determined by means of the electromagnetic field computation. The SCL main parameters are determined by the particle dynamics computation

  1. End-point construction and systematic titration error in linear titration curves-complexation reactions

    NARCIS (Netherlands)

    Coenegracht, P.M.J.; Duisenberg, A.J.M.

    1975-01-01

    The systematic titration error which is introduced by the intersection of tangents to hyperbolic titration curves is discussed. The effects of the apparent (conditional) formation constant, of the concentration of the unknown component and of the ranges used for the end-point construction are consid

  2. From experiment to design -- Fault characterization and detection in parallel computer systems using computational accelerators

    Science.gov (United States)

    Yim, Keun Soo

    This dissertation summarizes experimental validation and co-design studies conducted to optimize the fault detection capabilities and overheads in hybrid computer systems (e.g., using CPUs and Graphics Processing Units, or GPUs), and consequently to improve the scalability of parallel computer systems using computational accelerators. The experimental validation studies were conducted to help us understand the failure characteristics of CPU-GPU hybrid computer systems under various types of hardware faults. The main characterization targets were faults that are difficult to detect and/or recover from, e.g., faults that cause long latency failures (Ch. 3), faults in dynamically allocated resources (Ch. 4), faults in GPUs (Ch. 5), faults in MPI programs (Ch. 6), and microarchitecture-level faults with specific timing features (Ch. 7). The co-design studies were based on the characterization results. One of the co-designed systems has a set of source-to-source translators that customize and strategically place error detectors in the source code of target GPU programs (Ch. 5). Another co-designed system uses an extension card to learn the normal behavioral and semantic execution patterns of message-passing processes executing on CPUs, and to detect abnormal behaviors of those parallel processes (Ch. 6). The third co-designed system is a co-processor that has a set of new instructions in order to support software-implemented fault detection techniques (Ch. 7). The work described in this dissertation gains more importance because heterogeneous processors have become an essential component of state-of-the-art supercomputers. GPUs were used in three of the five fastest supercomputers that were operating in 2011. Our work included comprehensive fault characterization studies in CPU-GPU hybrid computers. In CPUs, we monitored the target systems for a long period of time after injecting faults (a temporally comprehensive experiment), and injected faults into various types of

  3. Current Lead Design for the Accelerator Project for Upgrade of LHC

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, Jeffrey S.; Cheban, Sergey; Feher, Sandor; Kaducak, Marc; Nobrega, Fred; Peterson, Tom

    2010-01-01

    The Accelerator Project for Upgrade of LHC (APUL) is a U.S. project participating in and contributing to CERN's Large Hadron Collider (LHC) upgrade program. In collaboration with Brookhaven National Laboratory, Fermilab is developing sub-systems for an upgrade of the LHC final focus magnet systems. A concept of main and auxiliary helium flow was developed that allows the superconductor to remain cold while the lead body warms up to prevent upper section frosting. The auxiliary flow will subsequently cool the thermal shields of the feed box and the transmission line cryostats. A thermal analysis of the current lead central heat exchange section was performed using analytic and FEA techniques. A method of remote soldering was developed that allows the current leads to be field replaceable. The remote solder joint was designed to be made without flux or additional solder, and able to be remade up to ten full cycles. A method of upper section attachment was developed that allows high pressure sealing of the helium volume. Test fixtures for both remote soldering and upper section attachment for the 13 kA lead were produced. The cooling concept, thermal analyses, and test results from both remote soldering and upper section attachment fixtures are presented.

  4. LIBO accelerates

    CERN Multimedia

    2002-01-01

    The prototype module of LIBO, a linear accelerator project designed for cancer therapy, has passed its first proton-beam acceleration test. In parallel a new version - LIBO-30 - is being developed, which promises to open up even more interesting avenues.

  5. Design, fabrication and first beam tests of the C-band RF acceleration unit at SINAP

    Science.gov (United States)

    Fang, Wencheng; Gu, Qiang; Sheng, Xing; Wang, Chaopeng; Tong, Dechun; Chen, Lifang; Zhong, Shaopeng; Tan, Jianhao; Lin, Guoqiang; Chen, Zhihao; Zhao, Zhentang

    2016-07-01

    C-band RF acceleration is a crucial technology for the compact Free Electron Laser (FEL) facility at the Shanghai Institute of Applied Physics (SINAP), Chinese Academy of Sciences. A project focusing on C-band RF acceleration technology was launched in 2008, based on high-gradient accelerating structures powered by klystron and pulse compressor units. The target accelerating gradient is 40 MV/m or higher. Recently one prototype of C-band RF unit, consisting of a 1.8 m accelerating structure and a klystron with a TE0115 mode pulse compressor, has been tested with high-power and electron beam. Stable operation at 40 MV/m was demonstrated and, 50 MV/m approached by the end of the test. This paper introduces the C-band R&D program at SINAP and presents the experiment results of high-power and beam tests.

  6. Ultra-High Gradient Channeling Acceleration in Nanostructures: Design/Progress of Proof-of-Concept (POC) Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Young min [Fermilab; Green, A. [NICADD, DeKalb; Lumpkin, A. H. [Fermilab; Thurman-Keup, R. M. [Fermilab; Shiltsev, V. [Fermilab; Zhang, X. [Shanghai, Inst. Optics, Fine Mech.; Farinella, D. M. [UC, Irvine; Taborek, P. [UC, Irvine; Tajima, T. [UC, Irvine; Wheeler, J. A. [U. Michigan, Ann Arbor; Mourou, G. [U. Michigan, Ann Arbor

    2016-09-16

    A short bunch of relativistic particles or a short-pulse laser perturbs the density state of conduction electrons in a solid crystal and excites wakefields along atomic lattices in a crystal. Under a coupling condition the wakes, if excited, can accelerate channeling particles with TeV/m acceleration gradients [1] in principle since the density of charge carriers (conduction electrons) in solids n0 = ~ 10 to the power of 20 – 10 to the power of 23 cm-3 is significantly higher than what was considered above in gaseous plasma. Nanostructures have some advantages over crystals for channeling applications of high power beams. The dechanneling rate can be reduced and the beam acceptance increased by the large size of the channels. For beam driven acceleration, a bunch length with a sufficient charge density would need to be in the range of the plasma wavelength to properly excite plasma wakefields, and channeled particle acceleration with the wakefields must occur before the ions in the lattices move beyond the restoring threshold. In the case of the excitation by short laser pulses, the dephasing length is appreciably increased with the larger channel, which enables channeled particles to gain sufficient amounts of energy. This paper describes simulation analyses on beam- and laser (X-ray)-driven accelerations in effective nanotube models obtained from Vsim and EPOCH codes. Experimental setups to detect wakefields are also outlined with accelerator facilities at Fermilab and NIU. In the FAST facility, the electron beamline was successfully commissioned at 50 MeV and it is being upgraded toward higher energies for electron accelerator R&D. The 50 MeV injector beamline of the facility is used for X-ray crystal-channeling radiation with a diamond target. It has been proposed to utilize the same diamond crystal for a channeling acceleration POC test. Another POC experiment is also designed for the NIU accelerator lab with time-resolved electron diffraction. Recently, a

  7. Development of accelerated test design for service-life prediction of solar array at Mead, Nebraska. Quarterly report

    Energy Technology Data Exchange (ETDEWEB)

    Gaines, G.B.; Thomas, R.E.; Noel, G.T.; Shilliday, T.S.; Wood, V.E.; Carmichael, D.C.

    1978-11-03

    As a significant beginning in applying accelerated tests to solar arrays for life-prediction purposes, this study is directed toward (a) developing a plan for predicting the service life of a specific solar array in a specific geographic site - viz., the 25-KW flat-plate array installed near Mead, Nebraska, and (b) developing technical information from laboratory and field measurements for designing an accelerated test that can be carried out in 2 years and have predictive validity for a service life as long as 20 years. Status of the program is described.

  8. Electromagnetic and beam dynamics design of a 5 MeV, 3 kW travelling wave electron linear accelerator

    International Nuclear Information System (INIS)

    An S-band (2856 MHz) 5 MeV, 3 kW traveling wave linear accelerator is currently under design and development at Raja Ramanna Centre for Advanced Technology, Indore. The accelerating structure is a 2π/3 mode constant impedance traveling wave structure, designed to accelerates the 50 keV electron beam from the electron gun to 5 MeV. It comprises of traveling wave buncher cells followed by regular accelerating cells. This paper presents the details of electromagnetic design simulations to fix the mechanical dimensions and tolerances, as well as heat loss calculations in the structure. Comparison of the results obtained from detailed numerical simulations with those obtained from approximate analytical calculations is described in the paper. The beam dynamics simulation from beginning to end of the linac is also performed and the required magnetic field profile for keeping the beam focused in the linac has been evaluated. The aim has been to maximize the capture efficiency with reduced energy spread in a short and compact structure. (author)

  9. Development of an accelerated test design for predicting the service life of the solar array at Mead, Nebraska

    Energy Technology Data Exchange (ETDEWEB)

    Gaines, G.B.; Thomas, R.E.; Noel, G.T.; Shilliday, T.S.; Wood, V.E.; Carmichael, D.C.

    1979-06-07

    This report describes an accelerated test which is designed to predict the life of the 25-kW photovoltaic array installed near Mead, Nebraska. Emphasis is placed on the power-output degradation at the module level and on long-term degradation modes, as appropriate for life prediction of mature devices for which infant failures are few. A quantitative model for accelerating testing using multiple environmental stresses is used to develop the test design. The model accounts for the effects of thermal stress by a relation of the Arrhenius form. This relation is then corrected for the effects of nonthermal environmental stresses such as relative humidity, atmospheric pollutants, and ultraviolet radiation. The test conditions, measurements, and data analyses for the accelerated tests are presented for determining the predicted life of the modules in service at Mead. Constant-temperature, cyclic-temperature, and uv types of tests are specified, incorporating selected levels of relative humidity and chemical contamination and an imposed forward-bias current and static electric field. It is recommended that as a first step in test implementation, the model be selectively validated using identified portions of the accelerated test design.

  10. Design, realization and test of C-band accelerating structures for the SPARC_LAB linac energy upgrade

    Science.gov (United States)

    Alesini, D.; Bellaveglia, M.; Biagini, M. E.; Boni, R.; Brönnimann, M.; Cardelli, F.; Chimenti, P.; Clementi, R.; Di Pirro, G.; Di Raddo, R.; Ferrario, M.; Ficcadenti, L.; Gallo, A.; Kalt, R.; Lollo, V.; Palumbo, L.; Piersanti, L.; Schilcher, T.

    2016-11-01

    The energy upgrade of the SPARC_LAB photo-injector at LNF-INFN (Frascati, Italy) has been originally conceived replacing one low gradient (13 MV/m) 3 m long SLAC type S-band traveling wave (TW) section with two 1.4 m long C-band accelerating sections. Due to the higher gradients reached by such structures, a higher energy beam can be obtained within the same accelerator footprint length. The use of C-band structures for electron acceleration has been adopted in a few FEL linacs in the world, among others, the Japanese Free Electron Laser at SPring-8 and the SwissFEL at Paul Scherrer Institute (PSI). The C-band sections are traveling wave, constant impedance structures with symmetric input and output axial couplers. Their design has been optimized for the operation with a SLED RF pulse compressor. In this paper we briefly review their design criteria and we focus on the construction, tuning, low and high-power RF tests. We also illustrate the design and realization of the dedicated low level RF system that has been done in collaboration with PSI in the framework of the EU TIARA project. Preliminary experimental results appear to confirm the operation of such structures with accelerating gradients larger than 35 MV/m.

  11. Titratable Acidity and Alkalinity of Red Soil Surfaces

    Institute of Scientific and Technical Information of China (English)

    SHAOZONG-CHEN; HEQUN; 等

    1993-01-01

    The surfaces of red soils have an apparent amphoteric character,carrying titratable acidity and titratable alkalinity simultaneously.The titratable acidity arises from deprotonation of hydroxyl groups of hydrous oxide-type surfaces and dissociation of weak-acid functional groups of soil organic matter,while the titratable alkalinity is derived from release of hydroxyl groups of hydrous oxide-type surfaces.The titratable acidity and titratable alkalinity mainly depended on the composition and content of iron and aluminum oxides in the soils.The results showed that the titratable acidity and titratable alkalinity were in significantly positive correlation not only with the content of amorphous aluminum oxide(Alo) and iron oxide(Feo) extracted with acid ammonium oxalate solution,free iron oxide(Fed) extracted with sodium dithionite-citrate-bicarbonate(DCB) and clays,but also with the zero point of charge (ZPC) of the samples.Organic matter made an important contribution to the titratable acidity.the titratable alkalinity was closely correlated with the amount of fluoride ions adsorbed.The titratable acidity and titratable alkalinity of red soils were influenced by parent materials,being in the order of red soil derived from basalt> that from tuff> that from granite.The titratable acidity and titratable alkalinity ware closely related with origination of the variable charges of red soils,and to a certain extent were responsible for variable negative and positive charges of the soils.

  12. Mechanical Design of a High Energy Beam Absorber for the Advanced Superconducting Test Accelerator (ASTA) at Fermilab

    CERN Document Server

    Baffes, C; Leibfritz, J; Oplt, S; Rakhno, I

    2013-01-01

    A high energy beam absorber has been built for the Advanced Superconducting Test Accelerator (ASTA) at Fermilab. In the facility's initial configuration, an electron beam will be accelerated through 3 TTF-type or ILC-type RF cryomodules to an energy of 750MeV. The electron beam will be directed to one of multiple downstream experimental and diagnostic beam lines and then deposited in one of two beam absorbers. The facility is designed to accommodate up to 6 cryomodules, which would produce a 75kW beam at 1.5GeV; this is the driving design condition for the beam absorbers. The beam absorbers consist of water-cooled graphite, aluminum and copper layers contained in a Helium-filled enclosure. This paper describes the mechanical implementation of the beam absorbers, with a focus on thermal design and analysis. In addition, the potential for radiation-induced degradation of the graphite is discussed.

  13. Mechanical Design of a High Energy Beam Absorber for the Advanced Superconducting Test Accelerator (ASTA) at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Baffes, C.; Church, M.; Leibfritz, J.; Oplt, S.; Rakhno, I.; /Fermilab

    2012-05-10

    A high energy beam absorber has been built for the Advanced Superconducting Test Accelerator (ASTA) at Fermilab. In the facility's initial configuration, an electron beam will be accelerated through 3 TTF-type or ILC-type SRF cryomodules to an energy of 750MeV. The electron beam will be directed to one of multiple downstream experimental and diagnostic beam lines and then deposited in one of two beam absorbers. The facility is designed to accommodate up to 6 cryomodules, which would produce a 75kW beam at 1.5GeV; this is the driving design condition for the beam absorbers. The beam absorbers consist of water-cooled graphite, aluminum and copper layers contained in a helium-filled enclosure. This paper describes the mechanical implementation of the beam absorbers, with a focus on thermal design and analysis. The potential for radiation-induced degradation of the graphite is discussed.

  14. The influence of the lay-out of beam diagnostic elements on the shielding design at the Tesla accelerator installation

    International Nuclear Information System (INIS)

    A number of devices are routinely used for collimation and beam diagnostics at accelerator installations. Some of them permanently cuts-off parts of the accelerated particles forming a distinct beam shape (slits and diaphragms). Others are used from time to time to give information on beam shape or current by intercepting the beam (Faraday cups, scintillators, wire grids). Due to a number of nuclear reactions resulted by the interaction of energetic particles with matter, these devices are strong sources of ionizing radiation and they must be considered in the shielding design procedure. The fast neutron equivalent dose rate is calculated for a certain lay-out of beam diagnostic elements at the 'Tesla' Accelerator Installation and their contribution to the equivalent dose is discussed. (author)

  15. Design of a beam shaping assembly and preliminary modelling of a treatment room for accelerator-based BNCT at CNEA

    International Nuclear Information System (INIS)

    This work reports on the characterisation of a neutron beam shaping assembly (BSA) prototype and on the preliminary modelling of a treatment room for BNCT within the framework of a research programme for the development and construction of an accelerator-based BNCT irradiation facility in Buenos Aires, Argentina. The BSA prototype constructed has been characterised by means of MCNP simulations as well as a set of experimental measurements performed at the Tandar accelerator at the National Atomic Energy Commission of Argentina. - Highlights: ► Characterisation of a neutron beam shaping assembly for accelerator-based BNCT. ► Measurements: total and epi-cadmium neutron fluxes and beam homogeneity. ► Calculations: Monte Carlo simulations with the MCNP code. ► Measured and calculated figure-of-merit parameters in agreement with those of IAEA. ► Initial MCNP dose calculations for a treatment room to define future design actions.

  16. Natural Monocrystalline Pyrite as Sensor for Potentiometric Redox Titrations. Part I. Titrations with Permanganate

    Directory of Open Access Journals (Sweden)

    B. V. Vukanovic

    2002-04-01

    Full Text Available Results obtained in potentiometric titrations of Fe(II, Mn(II, Fe(CN64-, C2O42- and As(III with standard potassium permanganate solution, are presented. The titration end point (TEP was detected with a universal electrode whose sensor is natural crystalline pyrite. The titrations of As(III were carried out in HCl (1.2 M and H2SO4 solutions (0.1- 4.5 M, whereas oxalate was determined in H2SO4 (0.1-4.5 M. Iron(II and hexacyanoferrate(II were titrated in H2SO4 and also in H3PO4 solutions (0.1-4.5 M. The titrations of Mn(II were performed in H2P2O72- media at pH 4.0, 5.0, 6.0 and 7.0. The results obtained by using the pyrite electrode were compared with those obtained by the application of a Pt-electrode, and good agreement, reproducibility and accuracy were obtained. The potentials in the course of the titration and at the end-point (TEP are rapidly established. The potential changes at the TEP ranged from 90 to 330 mV/0.1 mL, depending on the titrated system. The highest changes were observed in titrations of Fe(II in H3PO4 (240-330 mV/0.1 mL. Reversed titrations were also performed and accurate and reproducible results were obtained.

  17. Analysis of Transmitted Optical Spectrum Enabling Accelerated Testing of CPV Designs: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. C.; Kempe, M. D.; Kennedy, C. E.; Kurtz, S. R.

    2009-07-01

    Reliability of CPV systems' materials is not well known; methods for accelerated UV testing have not been developed. UV and IR spectra transmitted through representative optical systems are evaluated.

  18. Studies on a two-stage design for a high energy heavy ion accelerator

    International Nuclear Information System (INIS)

    The most prominent feature of any high energy heavy ions facility is the need for a multi-stage concept. In the first stage ions are accelerated to energies that, after stripping, ensure an abundance of fully ionized particles even for the heaviest elements, in the second stage all kinds of ions can then be accelerated under optimal conditions to extremely high energies and can eventually be stored for experiments with colliding ion beams. (orig./WL)

  19. Isothermal Titration Calorimetry in the Student Laboratory

    Science.gov (United States)

    Wadso, Lars; Li, Yujing; Li, Xi

    2011-01-01

    Isothermal titration calorimetry (ITC) is the measurement of the heat produced by the stepwise addition of one substance to another. It is a common experimental technique, for example, in pharmaceutical science, to measure equilibrium constants and reaction enthalpies. We describe a stirring device and an injection pump that can be used with a…

  20. An accelerator-based epithermal neutron beam design for BNCT and dosimetric evaluation using a voxel head phantom.

    Science.gov (United States)

    Lee, Deok-jae; Han, Chi Young; Park, Sung Ho; Kim, Jong Kyung

    2004-01-01

    The beam shaping assembly design has been investigated in order to improve the epithermal neutron beam for accelerator-based boron neutron capture therapy in intensity and quality, and dosimetric evaluation for the beams has been performed using both mathematical and voxel head phantoms with MCNP runs. The neutron source was assumed to be produced from a conventional 2.5 MeV proton accelerator with a thick (7)Li target. The results indicate that it is possible to enhance epithermal neutron flux remarkably as well as to embody a good spectrum shaping to epithermal neutrons only with the proper combination of moderator and reflector. It is also found that a larger number of thermal neutrons can reach deeply into the brain and, therefore, can reduce considerably the treatment time for brain tumours. Consequently, the epithermal neutron beams designed in this study can treat more effectively deep-seated brain tumours.

  1. Accelerator Quality HTS Dipole Magnet Demonstrator designs for the EuCARD-2, 5 Tesla 40 mm Clear Aperture Magnet

    CERN Document Server

    Kirby, G; Ballarino, A; Bottura, L; Chouika, N; Clement, S; Datskov, V; Fajardo, L; Fleiter, J; Gauthier, R; Lambert, L; Lopes, M; Perez, J; DeRijk, G; Rijllart, A; Rossi, L; Ten Kate, H; Durante, M; Fazilleau, P; Lorin, C; Haro, E; Stenvall, A; Caspi, S; Marchevsky, M; Goldacker, W; Kario, A

    2014-01-01

    Future high-energy accelerators will need very high magnetic fields in the range of 20 T. The EuCARD-2 work-package-10 is a collaborative push to take HTS materials into an accelerator quality demonstrator magnet. The demonstrator will produce 5 T standalone and between 17 T and 20 T, when inserted into the 100 mm aperture of Fresca-2 high field out-sert magnet. The HTS magnet will demonstrate the field strength and field quality that can be achieved. An effective quench detection and protection system will have to be developed to operate with the HTS superconducting materials. This paper presents a ReBCO magnet design using multi strand Roebel cable that develops a stand-alone field of 5 T in a 40 mm clear aperture and discusses the challenges associated with good field quality using this type of material. A selection of magnet designs is presented as result of a first phase of development.

  2. Accelerator Quality HTS Dipole Magnet Demonstrator Designs for the EuCARD-2, 5 Tesla 40 mm Clear Aperture Magnet

    CERN Document Server

    Kirby, G A; Ballarino, A; Bottura, L; Chouika, N; Clement, S; Datskov, V; Fajardo, L; Fleiter, J; Gauthier, R; Gentini, L; Lambert, L; Lopes, M; Perez, J C; de Rijk, G; Rijllart, A; Rossi, L; ten Kate, H; Durante, M; Fazilleau, P; Lorin, C; Härö, E; Stenvall, A; Caspi, S; Marchevsky, M; Goldacker, W; Kario, A

    2015-01-01

    Future high-energy accelerators will need very high magnetic fields in the range of 20 T. The EuCARD-2 work-package-10 is a collaborative push to take HTS materials into an accelerator quality demonstrator magnet. The demonstrator will produce 5 T standalone and between 17 T and 20 T, when inserted into the 100 mm aperture of Fresca-2 high field out-sert magnet. The HTS magnet will demonstrate the field strength and field quality that can be achieved. An effective quench detection and protection system will have to be developed to operate with the HTS superconducting materials. This paper presents a ReBCO magnet design using multi strand Roebel cable that develops a stand-alone field of 5 T in a 40 mm clear aperture and discusses the challenges associated with good field quality using this type of material. A selection of magnet designs is presented as result of a first phase of development.

  3. Titration Calorimetry Standards and the Precision of Isothermal Titration Calorimetry Data

    OpenAIRE

    Daumantas Matulis; Jurgita Matulienė; Vilma Petrikaitė; Lina Baranauskienė

    2009-01-01

    Current Isothermal Titration Calorimetry (ITC) data in the literature have relatively high errors in the measured enthalpies of protein-ligand binding reactions. There is a need for universal validation standards for titration calorimeters. Several inorganic salt co-precipitation and buffer protonation reactions have been suggested as possible enthalpy standards. The performances of several commercial calorimeters, including the VP-ITC, ITC200, and Nano ITC-III, were validated using these sug...

  4. Design study of Nb3Sn impregnated advanced accelerator dipole magnet. Final report

    International Nuclear Information System (INIS)

    The invention and development of particle accelerators and the associated technology has had a profound impact upon the progress which has been achieved in US Science and Technology. Improvements in accelerator performance to date have paced the science of particle physics. Equivalent beam energies have increased 107 times over the past 50 years. Reduction in unit energy costs of 106 times has also been realized over the same period. While both of these figures represent spectacular accomplishments, the cost reductions have not kept pace with energy increase. As a result, a limitation has had to be placed on the number and diversity of high energy accelerator facilities. Further limitations can be expected if the cost/energy trends continue. The problem then becomes one of achieving an increased rate of unit energy cost reduction while maintaining performance improvement. The solution involves: full exploitation of the potential of the current accelerator technologies, and invention of entirely new technologies and methods. The present study falls into the first of these approaches in which General Electric's Advanced Energy Programs Department in Schenectady, NY was asked to assess the feasibility of applying its proven epoxy impregnation process to high field accelerator magnets. This report details the results of Phase 1 of this study

  5. Implementation of the accelerated reader program in a designated disadvantaged second-level school : a case study

    OpenAIRE

    Moran, Catherine (Kathleen)

    2009-01-01

    The purpose of this study was to determine whether a specific computer-based reading development programme i.e. the Accelerated Reader Program, when implemented through a professionally staffed school library, actually impacts on the reading comprehension and literacy development of underachieving adolescent students who are participating in the Junior Certificate School Programme in a designated disadvantaged school. The study also sought to determine the extent to which the participating st...

  6. An Olfactory Indicator for Acid-Base Titrations.

    Science.gov (United States)

    Flair, Mark N.; Setzer, William N.

    1990-01-01

    The use of an olfactory acid-base indicator in titrations for visually impaired students is discussed. Potential olfactory indicators include eugenol, thymol, vanillin, and thiophenol. Titrations performed with each indicator with eugenol proved to be successful. (KR)

  7. Design and status of the SuperKEKB accelerator control network system

    International Nuclear Information System (INIS)

    We have upgraded the accelerator control network system for SuperKEKB, the next generation B-factory experiment in Japan. The new network system has the higher performance based on the wider bandwidth data transfer, and more reliable and redundant network configuration. We have changed the network configuration on the connection of the KEK laboratory network to enhance the network security. We also introduced the VLAN segmentation into the new network system. For the SuperKEKB construction, the new wireless network system has installed into the whole 3 km circumference accelerator tunnel. (author)

  8. Design of high-speed data transmission system for Lanzhou heavy ion therapy accelerator

    International Nuclear Information System (INIS)

    In order to satisfy the transmission requirements of partial synchronization data and process data for the heavy ion therapy accelerator, a high-speed, error-correction, long-distance, and real-time data transmission system was proposed and achieved. It can improve the efficiency and reliability of the accelerator control and synchronization. The system optimizes the hardware configuration and layout of the traditional system. FPGA, gigabit fiber module, PXI and SDRAM are the main parts of the system. It replaces the low-speed, short-distance, and poor anti-interference of the traditional data path and the data processing chips. Through the programming in the two FPGA chips, the PXI and DMA transmission mode was used to exchange data with the server of the accelerator. The front-end of the system achieves a real-time, long-distance, and high-speed serial frame transmission with 800 MHz carrier and 100 MHz base band signal. The real-time -data like synchronous event signal, power waveform data of the heavy ion therapy accelerator can be transmitted efficiently between the server and the remote controller through the system. (authors)

  9. Design of Power Efficient FPGA based Hardware Accelerators for Financial Applications

    DEFF Research Database (Denmark)

    Hegner, Jonas Stenbæk; Sindholt, Joakim; Nannarelli, Alberto

    2012-01-01

    Using Field Programmable Gate Arrays (FPGAs) to accelerate financial derivative calculations is becoming very common. In this work, we implement an FPGA-based specific processor for European option pricing using Monte Carlo simulations, and we compare its performance and power dissipation to the ...

  10. Acceleration of Deep Neural Network Training with Resistive Cross-Point Devices: Design Considerations.

    Science.gov (United States)

    Gokmen, Tayfun; Vlasov, Yurii

    2016-01-01

    In recent years, deep neural networks (DNN) have demonstrated significant business impact in large scale analysis and classification tasks such as speech recognition, visual object detection, pattern extraction, etc. Training of large DNNs, however, is universally considered as time consuming and computationally intensive task that demands datacenter-scale computational resources recruited for many days. Here we propose a concept of resistive processing unit (RPU) devices that can potentially accelerate DNN training by orders of magnitude while using much less power. The proposed RPU device can store and update the weight values locally thus minimizing data movement during training and allowing to fully exploit the locality and the parallelism of the training algorithm. We evaluate the effect of various RPU device features/non-idealities and system parameters on performance in order to derive the device and system level specifications for implementation of an accelerator chip for DNN training in a realistic CMOS-compatible technology. For large DNNs with about 1 billion weights this massively parallel RPU architecture can achieve acceleration factors of 30, 000 × compared to state-of-the-art microprocessors while providing power efficiency of 84, 000 GigaOps∕s∕W. Problems that currently require days of training on a datacenter-size cluster with thousands of machines can be addressed within hours on a single RPU accelerator. A system consisting of a cluster of RPU accelerators will be able to tackle Big Data problems with trillions of parameters that is impossible to address today like, for example, natural speech recognition and translation between all world languages, real-time analytics on large streams of business and scientific data, integration, and analysis of multimodal sensory data flows from a massive number of IoT (Internet of Things) sensors.

  11. Acceleration of Deep Neural Network Training with Resistive Cross-Point Devices: Design Considerations.

    Science.gov (United States)

    Gokmen, Tayfun; Vlasov, Yurii

    2016-01-01

    In recent years, deep neural networks (DNN) have demonstrated significant business impact in large scale analysis and classification tasks such as speech recognition, visual object detection, pattern extraction, etc. Training of large DNNs, however, is universally considered as time consuming and computationally intensive task that demands datacenter-scale computational resources recruited for many days. Here we propose a concept of resistive processing unit (RPU) devices that can potentially accelerate DNN training by orders of magnitude while using much less power. The proposed RPU device can store and update the weight values locally thus minimizing data movement during training and allowing to fully exploit the locality and the parallelism of the training algorithm. We evaluate the effect of various RPU device features/non-idealities and system parameters on performance in order to derive the device and system level specifications for implementation of an accelerator chip for DNN training in a realistic CMOS-compatible technology. For large DNNs with about 1 billion weights this massively parallel RPU architecture can achieve acceleration factors of 30, 000 × compared to state-of-the-art microprocessors while providing power efficiency of 84, 000 GigaOps∕s∕W. Problems that currently require days of training on a datacenter-size cluster with thousands of machines can be addressed within hours on a single RPU accelerator. A system consisting of a cluster of RPU accelerators will be able to tackle Big Data problems with trillions of parameters that is impossible to address today like, for example, natural speech recognition and translation between all world languages, real-time analytics on large streams of business and scientific data, integration, and analysis of multimodal sensory data flows from a massive number of IoT (Internet of Things) sensors. PMID:27493624

  12. Acceleration of Deep Neural Network Training with Resistive Cross-Point Devices: Design Considerations

    Science.gov (United States)

    Gokmen, Tayfun; Vlasov, Yurii

    2016-01-01

    In recent years, deep neural networks (DNN) have demonstrated significant business impact in large scale analysis and classification tasks such as speech recognition, visual object detection, pattern extraction, etc. Training of large DNNs, however, is universally considered as time consuming and computationally intensive task that demands datacenter-scale computational resources recruited for many days. Here we propose a concept of resistive processing unit (RPU) devices that can potentially accelerate DNN training by orders of magnitude while using much less power. The proposed RPU device can store and update the weight values locally thus minimizing data movement during training and allowing to fully exploit the locality and the parallelism of the training algorithm. We evaluate the effect of various RPU device features/non-idealities and system parameters on performance in order to derive the device and system level specifications for implementation of an accelerator chip for DNN training in a realistic CMOS-compatible technology. For large DNNs with about 1 billion weights this massively parallel RPU architecture can achieve acceleration factors of 30, 000 × compared to state-of-the-art microprocessors while providing power efficiency of 84, 000 GigaOps∕s∕W. Problems that currently require days of training on a datacenter-size cluster with thousands of machines can be addressed within hours on a single RPU accelerator. A system consisting of a cluster of RPU accelerators will be able to tackle Big Data problems with trillions of parameters that is impossible to address today like, for example, natural speech recognition and translation between all world languages, real-time analytics on large streams of business and scientific data, integration, and analysis of multimodal sensory data flows from a massive number of IoT (Internet of Things) sensors. PMID:27493624

  13. Optimal Design of Multiple Stresses Accelerated Life Test Plan Based on Transforming the Multiple Stresses to Single Stress

    Institute of Scientific and Technical Information of China (English)

    GAO Liang; CHEN Wenhua; QIAN Ping; PAN Jun; HE Qingchuan

    2014-01-01

    For planning optimum multiple stresses accelerated life test plans, a commonly followed guiding principle is that all parameters of the life-stress relationship should be estimated, and the number of the stress level combinations must be no less than the number of parameters of the life-stress relationship. However, the general objective of an accelerated life test(ALT) is to assess thep-th quantile of the product life distribution under normal stress. For this objective,estimating all model parameters is not necessary, and this will increase the cost of test. Based on the theoretical conclusion that the stress level combinations of the optimum multiple stresses ALT plan locate on a straight line through the origin of coordinate, it is proposed that a design idea of planning the optimum multiple stresses ALT plan through transforming the problem of designing an optimum multiple stresses ALT plan to designing an optimum single stress ALT plan. Moreover, a method of planning the optimum multiple stresses ALT plan which can avoid estimating all model parameters is established. An example shows that, the proposed plan which only has two stress level combinations could achieve an accuracy no less than the traditional plan, and save the test time and cost on one stress level combination at least; when the actual product life is less than the design value, even the deviation of the model initial parameters value is up to 20%, the variance of the estimation of thep-th quantile of the proposed plan is still smaller than the traditional plans approximately 25%. A design method is provided for planning the optimum multiple stresses ALT which uses the statistical optimum degenerate test plan as the optimum multiple stresses accelerated life test plan.

  14. Digital movie-based on automatic titrations.

    Science.gov (United States)

    Lima, Ricardo Alexandre C; Almeida, Luciano F; Lyra, Wellington S; Siqueira, Lucas A; Gaião, Edvaldo N; Paiva Junior, Sérgio S L; Lima, Rafaela L F C

    2016-01-15

    This study proposes the use of digital movies (DMs) in a flow-batch analyzer (FBA) to perform automatic, fast and accurate titrations. The term used for this process is "Digital movie-based on automatic titrations" (DMB-AT). A webcam records the DM during the addition of the titrant to the mixing chamber (MC). While the DM is recorded, it is decompiled into frames ordered sequentially at a constant rate of 26 frames per second (FPS). The first frame is used as a reference to define the region of interest (ROI) of 28×13pixels and the R, G and B values, which are used to calculate the Hue (H) values for each frame. The Pearson's correlation coefficient (r) is calculated between the H values of the initial frame and each subsequent frame. The titration curves are plotted in real time using the r values and the opening time of the titrant valve. The end point is estimated by the second derivative method. A software written in C language manages all analytical steps and data treatment in real time. The feasibility of the method was attested by application in acid/base test samples and edible oils. Results were compared with classical titration and did not present statistically significant differences when the paired t-test at the 95% confidence level was applied. The proposed method is able to process about 117-128 samples per hour for the test and edible oil samples, respectively, and its precision was confirmed by overall relative standard deviation (RSD) values, always less than 1.0%. PMID:26592600

  15. Analysis of Cooperativity by Isothermal Titration Calorimetry

    OpenAIRE

    Alan Brown

    2009-01-01

    Cooperative binding pervades Nature. This review discusses the use of isothermal titration calorimetry (ITC) in the identification and characterisation of cooperativity in biological interactions. ITC has broad scope in the analysis of cooperativity as it determines binding stiochiometries, affinities and thermodynamic parameters, including enthalpy and entropy in a single experiment. Examples from the literature are used to demonstrate the applicability of ITC in the characterisation of coop...

  16. Conceptual designs of two petawatt-class pulsed-power accelerators for high-energy-density-physics experiments

    Science.gov (United States)

    Stygar, W. A.; Awe, T. J.; Bailey, J. E.; Bennett, N. L.; Breden, E. W.; Campbell, E. M.; Clark, R. E.; Cooper, R. A.; Cuneo, M. E.; Ennis, J. B.; Fehl, D. L.; Genoni, T. C.; Gomez, M. R.; Greiser, G. W.; Gruner, F. R.; Herrmann, M. C.; Hutsel, B. T.; Jennings, C. A.; Jobe, D. O.; Jones, B. M.; Jones, M. C.; Jones, P. A.; Knapp, P. F.; Lash, J. S.; LeChien, K. R.; Leckbee, J. J.; Leeper, R. J.; Lewis, S. A.; Long, F. W.; Lucero, D. J.; Madrid, E. A.; Martin, M. R.; Matzen, M. K.; Mazarakis, M. G.; McBride, R. D.; McKee, G. R.; Miller, C. L.; Moore, J. K.; Mostrom, C. B.; Mulville, T. D.; Peterson, K. J.; Porter, J. L.; Reisman, D. B.; Rochau, G. A.; Rochau, G. E.; Rose, D. V.; Rovang, D. C.; Savage, M. E.; Sceiford, M. E.; Schmit, P. F.; Schneider, R. F.; Schwarz, J.; Sefkow, A. B.; Sinars, D. B.; Slutz, S. A.; Spielman, R. B.; Stoltzfus, B. S.; Thoma, C.; Vesey, R. A.; Wakeland, P. E.; Welch, D. R.; Wisher, M. L.; Woodworth, J. R.

    2015-11-01

    We have developed conceptual designs of two petawatt-class pulsed-power accelerators: Z 300 and Z 800. The designs are based on an accelerator architecture that is founded on two concepts: single-stage electrical-pulse compression and impedance matching [Phys. Rev. ST Accel. Beams 10, 030401 (2007)]. The prime power source of each machine consists of 90 linear-transformer-driver (LTD) modules. Each module comprises LTD cavities connected electrically in series, each of which is powered by 5-GW LTD bricks connected electrically in parallel. (A brick comprises a single switch and two capacitors in series.) Six water-insulated radial-transmission-line impedance transformers transport the power generated by the modules to a six-level vacuum-insulator stack. The stack serves as the accelerator's water-vacuum interface. The stack is connected to six conical outer magnetically insulated vacuum transmission lines (MITLs), which are joined in parallel at a 10-cm radius by a triple-post-hole vacuum convolute. The convolute sums the electrical currents at the outputs of the six outer MITLs, and delivers the combined current to a single short inner MITL. The inner MITL transmits the combined current to the accelerator's physics-package load. Z 300 is 35 m in diameter and stores 48 MJ of electrical energy in its LTD capacitors. The accelerator generates 320 TW of electrical power at the output of the LTD system, and delivers 48 MA in 154 ns to a magnetized-liner inertial-fusion (MagLIF) target [Phys. Plasmas 17, 056303 (2010)]. The peak electrical power at the MagLIF target is 870 TW, which is the highest power throughout the accelerator. Power amplification is accomplished by the centrally located vacuum section, which serves as an intermediate inductive-energy-storage device. The principal goal of Z 300 is to achieve thermonuclear ignition; i.e., a fusion yield that exceeds the energy transmitted by the accelerator to the liner. 2D magnetohydrodynamic (MHD) simulations

  17. A monosegmented-flow Karl Fischer titrator.

    Science.gov (United States)

    de Aquino, Emerson Vidal; Rohwedder, Jarbas José Rodrigues; Pasquini, Celio

    2007-02-28

    A monosegmented volumetric Karl Fischer titrator is described to mechanize the determination of water content in organic solvents. The system is based on the flow-batch characteristics of the monosegmented analysis concept and employs biamperometry to monitor the progress of the titration. The system shows accuracy and precision that are highly independent of the flow rate, does not require calibration, and is carried out in a closed system capable of minimizing contact of the sample and reagents with ambient moisture. Sample volumes in the range of 40-300muL are employed, depending on the water concentration. An automatic dilution is provided to deal with concentrated samples. The consumption of Karl Fischer reagent depends on the water content of the sample but is not larger than 100muL. The system was evaluated for determination of water in ethanol and methanol in the range 0.02-0.5% (w/w). The average relative precision estimated in that range (9-3%) is comparable to that obtained with a larger volume commercial system and no significant difference was observed between the results obtained for the two systems at the 95% confidence level. A complete titration can be performed in less than 5min employing the proposed system. PMID:19071447

  18. Design of 7 MeV drift tube linac as injector of proton accelerator for cancer therapy

    International Nuclear Information System (INIS)

    A 324 MHz drift-tube linac(DTL) is designed for proton cancer therapy. The design demands low power dissipation and short tank. The DTL accelerates beam from 2.5 MeV to 7 MeV, with RF power of 265 kW and total length of 1.9 m. The DTL uses permanent-quadrupole magnet(PQM) inside the drift tubes arranged in an FODO lattice. A new matching method is designed. In stead of the traditional beam transport line, the first four cells in DTL are designed as matching section. It causes the beam ellipse from radio-frequency quadrupole linac(RFQ) to satisfy conditions specified by the DTL periodic structure. The dynamics simulation was performed with PARMILA, and almost no emittance growth has been found. (authors)

  19. Toward a physics design for NDCX-II, an ion accelerator for warm dense matter and HIF target physics studies

    International Nuclear Information System (INIS)

    The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL), a collaboration of LBNL, LLNL, and PPPL, has achieved 60-fold pulse compression of ion beams on the Neutralized Drift Compression eXperiment (NDCX) at LBNL. In NDCX, a ramped voltage pulse from an induction cell imparts a velocity 'tilt' to the beam; the beam's tail then catches up with its head in a plasma environment that provides neutralization. The HIFS-VNL's mission is to carry out studies of Warm Dense Matter (WDM) physics using ion beams as the energy source; an emerging thrust is basic target physics for heavy ion-driven Inertial Fusion Energy (IFE). These goals require an improved platform, labeled NDCX-II. Development of NDCX-II at modest cost was recently enabled by the availability of induction cells and associated hardware from the decommissioned Advanced Test Accelerator (ATA) facility at LLNL. Our initial physics design concept accelerates a ∼30 nC pulse of Li+ ions to ∼3 MeV, then compresses it to ∼1 ns while focusing it onto a mm-scale spot. It uses the ATA cells themselves (with waveforms shaped by passive circuits) to impart the final velocity tilt; smart pulsers provide small corrections. The ATA accelerated electrons; acceleration of non-relativistic ions involves more complex beam dynamics both transversely and longitudinally. We are using analysis, an interactive one-dimensional kinetic simulation model, and multidimensional Warp-code simulations to develop the NDCX-II accelerator section. Both LSP and Warp codes are being applied to the beam dynamics in the neutralized drift and final focus regions, and the plasma injection process. The status of this effort is described

  20. Toward a physics design for NDCX-II, an ion accelerator for warm dense matter and HIF target physics studies

    Science.gov (United States)

    Friedman, A.; Barnard, J. J.; Briggs, R. J.; Davidson, R. C.; Dorf, M.; Grote, D. P.; Henestroza, E.; Lee, E. P.; Leitner, M. A.; Logan, B. G.; Sefkow, A. B.; Sharp, W. M.; Waldron, W. L.; Welch, D. R.; Yu, S. S.

    2009-07-01

    The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL), a collaboration of LBNL, LLNL, and PPPL, has achieved 60-fold pulse compression of ion beams on the Neutralized Drift Compression eXperiment (NDCX) at LBNL. In NDCX, a ramped voltage pulse from an induction cell imparts a velocity "tilt" to the beam; the beam's tail then catches up with its head in a plasma environment that provides neutralization. The HIFS-VNL's mission is to carry out studies of warm dense matter (WDM) physics using ion beams as the energy source; an emerging thrust is basic target physics for heavy ion-driven inertial fusion energy (IFE). These goals require an improved platform, labeled NDCX-II. Development of NDCX-II at modest cost was recently enabled by the availability of induction cells and associated hardware from the decommissioned advanced test accelerator (ATA) facility at LLNL. Our initial physics design concept accelerates a ˜30 nC pulse of Li+ ions to ˜3 MeV, then compresses it to ˜1 ns while focusing it onto a mm-scale spot. It uses the ATA cells themselves (with waveforms shaped by passive circuits) to impart the final velocity tilt; smart pulsers provide small corrections. The ATA accelerated electrons; acceleration of non-relativistic ions involves more complex beam dynamics both transversely and longitudinally. We are using an interactive one-dimensional kinetic simulation model and multidimensional Warp-code simulations to develop the NDCX-II accelerator section. Both LSP and Warp codes are being applied to the beam dynamics in the neutralized drift and final focus regions, and the plasma injection process. The status of this effort is described.

  1. Conceptual design of minor actinides burner with an accelerator-driven subcritical system.

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Y.; Gohar, Y. (Nuclear Engineering Division)

    2011-11-04

    In the environmental impact study of the Yucca Mountain nuclear waste repository, the limit of spent nuclear fuel (SNF) for disposal is assessed at 70,000 metric tons of heavy metal (MTHM), among which 63,000 MTHM are the projected SNF discharge from U.S. commercial nuclear power plants though 2011. Within the 70,000 MTHM of SNF in storage, approximately 115 tons would be minor actinides (MAs) and 585 tons would be plutonium. This study describes the conceptual design of an accelerator-driven subcritical (ADS) system intended to utilize (burn) the 115 tons of MAs. The ADS system consists of a subcritical fission blanket where the MAs fuel will be burned, a spallation neutron source to drive the fission blanket, and a radiation shield to reduce the radiation dose to an acceptable level. The spallation neutrons are generated from the interaction of a 1 GeV proton beam with a lead-bismuth eutectic (LBE) or liquid lead target. In this concept, the fission blanket consists of a liquid mobile fuel and the fuel carrier can be LBE, liquid lead, or molten salt. The actinide fuel materials are dissolved, mixed, or suspended in the liquid fuel carrier. Therefore, fresh fuel can be fed into the fission blanket to adjust its reactivity and to control system power during operation. Monte Carlo analyses were performed to determine the overall parameters of an ADS system utilizing LBE as an example. Steady-state Monte Carlo simulations were studied for three fission blanket configurations that are similar except that the loaded amount of actinide fuel in the LBE is either 5, 7, or 10% of the total volume of the blanket, respectively. The neutron multiplication factor values of the three configurations are all approximately 0.98 and the MA initial inventories are each approximately 10 tons. Monte Carlo burnup simulations using the MCB5 code were performed to analyze the performance of the three conceptual ADS systems. Preliminary burnup analysis shows that all three conceptual ADS

  2. Delayed resonator with acceleration feedback - Complete stability analysis by spectral methods and vibration absorber design

    Science.gov (United States)

    Vyhlídal, Tomáš; Olgac, Nejat; Kučera, Vladimír

    2014-12-01

    This paper deals with the problem of active vibration suppression using the concept of delayed resonator (DR) absorber with acceleration feedback. A complete dynamic analysis of DR and its coupling with a single degree of freedom mechanical system are performed. Due to the presence of a delay in the acceleration feedback, the dynamics of the resonator itself, as well as the dynamics of combined system are of ‘neutral' character. On this system, spectral methods are applied to perform a complete stability analysis. Particularly, the method of cluster treatment of characteristic roots is used to determine stability boundaries in the space of the resonator parameters. Based on this analysis, a methodology to select the resonator parameters is proposed in order to guarantee desirable suppression characteristics and to provide safe stability margins. An example case study is included to demonstrate these analytical results.

  3. STRUCTURAL DESIGN CRITERIA FOR TARGET/BLANKET SYSTEM COMPONENT MATERIALS FOR THE ACCELERATOR PRODUCTION OF TRITIUM PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    W. JOHNSON; R. RYDER; P. RITTENHOUSE

    2001-01-01

    The design of target/blanket system components for the Accelerator Production of Tritium (APT) plant is dependent on the development of materials properties data specified by the designer. These data are needed to verify that component designs are adequate. The adequacy of the data will be related to safety, performance, and economic considerations, and to other requirements that may be deemed necessary by customers and regulatory bodies. The data required may already be in existence, as in the open technical literature, or may need to be generated, as is often the case for the design of new systems operating under relatively unique conditions. The designers' starting point for design data needs is generally some form of design criteria used in conjunction with a specified set of loading conditions and associated performance requirements. Most criteria are aimed at verifying the structural adequacy of the component, and often take the form of national or international standards such as the ASME Boiler and Pressure Vessel Code (ASME B and PV Code) or the French Nuclear Structural Requirements (RCC-MR). Whether or not there are specific design data needs associated with the use of these design criteria will largely depend on the uniqueness of the conditions of operation of the component. A component designed in accordance with the ASME B and PV Code, where no unusual environmental conditions exist, will utilize well-documented, statistically-evaluated developed in conjunction with the Code, and will not be likely to have any design data needs. On the other hand, a component to be designed to operate under unique APT conditions, is likely to have significant design data needs. Such a component is also likely to require special design criteria for verification of its structural adequacy, specifically accounting for changes in materials properties which may occur during exposure in the service environment. In such a situation it is common for the design criteria

  4. Design studies and commissioning plans for plasma acceleration research station experimental program

    Energy Technology Data Exchange (ETDEWEB)

    Mete, O.; Xia, G.; Hanahoe, K. [School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL (United Kingdom); The Cockcroft Institute, Sci-Tech Daresbury, Warrington, Halton WA4 4AD (United Kingdom); Dover, M.; Wigram, M.; Wright, J.; Zhang, J. [School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL (United Kingdom); Smith, J. [Tech-X UK Ltd, Sci-Tech Daresbury, Warrington, Cheshire WA4 4FS (United Kingdom)

    2015-10-15

    Plasma acceleration research station is an electron beam driven plasma wakefield acceleration test stand proposed for CLARA facility in Daresbury Laboratory. In this paper, the interaction between the electron beam and the plasma is numerically characterised via 2D numerical studies by using VSIM code. The wakefields induced by a single bunch travelling through the plasma were found to vary from 200 MV/m to 3 GV/m for a range of bunch length, bunch radius, and plasma densities. Energy gain for the particles populating the bunch tail through the wakefields driven by the head of the bunch was demonstrated. After determining the achievable field for various beams and plasma configurations, a reference setting was determined for further studies. Considering this reference setting, the beam quality studies were performed for a two-bunch acceleration case. The maximum energy gain as well as the energy spread mitigation by benefiting from the beam loading was investigated by positioning the witness and driver bunches with respect to each other. Emittance growth mechanisms were studied considering the beam-plasma and beam-wakefield interactions. Eventually, regarding the findings, the initial commissioning plans and the aims for the later stages were summarised.

  5. Design of an accelerator-based neutron source for neutron capture therapy

    International Nuclear Information System (INIS)

    The boron neutron capture therapy is mainly suited in the treatment of some tumor kinds which revealed ineffective to the traditional radiotherapy. In order to take advantage of such a therapeutic modality in hospital environments, neutron beams of suitable energy and flux levels provided by compact size facilities are needed. The advantages and drawbacks of several neutron beams are here analysed in terms of therapeutic gains. In detail the GEANT-3/MICAP simulations show that high tumor control probability, with sub-lethal dose at healthy tissues, can be achieved by using neutron beams of few keV energy having a flux of about 109 neutrons/(cm2 s). To produce such a neutron beam, the feasibility of a proton accelerator is investigated. In particular an appropriate choice of the radiofrequency parameters (modulation, efficiency of acceleration, phase shift, etc.) allows the development of relatively compact accelerators, having a proton beam current of 30 mA and an energy of 2 MeV, which could eventually lead to setting up of hospital-based neutron facilities.

  6. Infrared Turbidimetric Titration Method for Sulfate Ions in Brackish Water

    Directory of Open Access Journals (Sweden)

    Benabadji Nouredine

    2012-12-01

    Full Text Available In this work an infrared turbidimetric titration method is described for the determination of sulfate ions in brackish water. A suspension of barium sulfate is produced in an aqueous solution and/or brackish water sample by the addition of barium chloride solution and the turbidity is monitored with the help of an immersed infrared sensor. The developed sensor utilizes an optical system to measure the evolution of turbidity during the titration. This sensor is a simple device designed in the laboratory, consisting of two infrared diodes (LED, the first is an emitter and the second is used as detector (receiver. The data acquisition system is made with the help of a dataloger made on the basis of the microcontroller 16F877/874 accompanied with adaptable software both of them are self made. Concentration over 60 µg/mL of sulfate expressed as, SO42- can be measured with high reproducibility, by this method without a preliminary treatment or dilution of the sample. The method determines SO42 - concentration of brackish water with RSD of < 1.2%.

  7. Measuring the Kinetics of Molecular Association by Isothermal Titration Calorimetry.

    Science.gov (United States)

    Vander Meulen, Kirk A; Horowitz, Scott; Trievel, Raymond C; Butcher, Samuel E

    2016-01-01

    The real-time power response inherent in an isothermal titration calorimetry (ITC) experiment provides an opportunity to directly analyze association kinetics, which, together with the conventional measurement of thermodynamic quantities, can provide an incredibly rich description of molecular binding in a single experiment. Here, we detail our application of this method, in which interactions occurring with relaxation times ranging from slightly below the instrument response time constant (12.5 s in this case) to as large as 600 s can be fully detailed in terms of both the thermodynamics and kinetics. In a binding titration scenario, in the most general case an injection can reveal an association rate constant (kon). Under more restrictive conditions, the instrument time constant-corrected power decay following each injection is simply an exponential decay described by a composite rate constant (kobs), from which both kon and the dissociation rate constant (koff) can be extracted. The data also support the viability of this exponential approach, for kon only, for a slightly larger set of conditions. Using a bimolecular RNA folding model and a protein-ligand interaction, we demonstrate and have internally validated this approach to experiment design, data processing, and error analysis. An updated guide to thermodynamic and kinetic regimes accessible by ITC is provided.

  8. A microfabrication-based approach to quantitative isothermal titration calorimetry.

    Science.gov (United States)

    Wang, Bin; Jia, Yuan; Lin, Qiao

    2016-04-15

    Isothermal titration calorimetry (ITC) directly measures heat evolved in a chemical reaction to determine equilibrium binding properties of biomolecular systems. Conventional ITC instruments are expensive, use complicated design and construction, and require long analysis times. Microfabricated calorimetric devices are promising, although they have yet to allow accurate, quantitative ITC measurements of biochemical reactions. This paper presents a microfabrication-based approach to integrated, quantitative ITC characterization of biomolecular interactions. The approach integrates microfabricated differential calorimetric sensors with microfluidic titration. Biomolecules and reagents are introduced at each of a series of molar ratios, mixed, and allowed to react. The reaction thermal power is differentially measured, and used to determine the thermodynamic profile of the biomolecular interactions. Implemented in a microdevice featuring thermally isolated, well-defined reaction volumes with minimized fluid evaporation as well as highly sensitive thermoelectric sensing, the approach enables accurate and quantitative ITC measurements of protein-ligand interactions under different isothermal conditions. Using the approach, we demonstrate ITC characterization of the binding of 18-Crown-6 with barium chloride, and the binding of ribonuclease A with cytidine 2'-monophosphate within reaction volumes of approximately 0.7 µL and at concentrations down to 2mM. For each binding system, the ITC measurements were completed with considerably reduced analysis times and material consumption, and yielded a complete thermodynamic profile of the molecular interaction in agreement with published data. This demonstrates the potential usefulness of our approach for biomolecular characterization in biomedical applications.

  9. Automatic set-point titration for monitoring nitrification in SBRs.

    Science.gov (United States)

    Fiocchi, N; Ficara, E; Bonelli, S; Canziani, R; Ciappelloni, F; Mariani, S; Pirani, M; Ratini, P; Mazouni, D; Harmand, J

    2008-01-01

    Nitrification is usually the bottleneck of biological nitrogen removal processes. In SBRs systems, it is not often enough to monitor dissolved oxygen, pH and ORP to spot problems which may occur in nitrification processes. Therefore, automated supervision systems should be designed to include the possibility of monitoring the activity of nitrifying populations. Though the applicability of set-point titration for monitoring biological processes has been widely demonstrated in the literature, the possibility of an automated procedure is still at its early stage of industrial development. In this work, the use of an at-line automated titrator named TITAAN (TITrimetric Automated ANalyser) is presented. The completely automated sensor enables us to track nitrification rate trend with time in an SBR, detecting the causes leading to slower specific nitrification rates. It was also possible to perform early detection of toxic compounds in the influent by assessing their effect on the nitrifying biomass. Nitrifications rates were determined with average errors+/-10% (on 26 tests), never exceeding 20% as compared with UV-spectrophotometric determinations. PMID:18701782

  10. Low-field permanent magnet quadrupoles in a new relativistic-klystron two-beam accelerator design

    Energy Technology Data Exchange (ETDEWEB)

    Yu, S.; Sessler, A. [Lawrence Berkeley Lab., CA (United States)

    1995-02-01

    Permanent magnets play a central role in the new relativistic klystron two-beam-accelerator design. The two key goals of this new design, low cost and the suppression of beam break-up instability are both intimately tied to the permanent magnet quadrupole focusing system. A recently completed systems study by a joint LBL-LLNL team concludes that a power source for a 1 TeV center-of-mass Next Linear Collider based on the new TBA design can be as low as $1 billion, and the efficiency (wall plug to rf) is estimated to be 36%. End-to-end simulations of longitudinal and transverse beam dynamics show that the drive beam is stable over the entire TBA unit.

  11. THE MECHANICAL AND SHIELDING DESIGN OF A PORTABLE SPECTROMETER AND BEAM DUMP ASSEMBLY AT BNLS ACCELERATOR TEST FACILITY.

    Energy Technology Data Exchange (ETDEWEB)

    HU,J.P.; CASEY,W.R.; HARDER,D.A.; PJEROV,S.; RAKOWSKY,G.; SKARITKA,J.R.

    2002-09-05

    A portable assembly containing a vertical-bend dipole magnet has been designed and installed immediately down-beam of the Compton electron-laser interaction chamber on beamline 1 of the Accelerator Test Facility (ATF) at Brookhaven National Laboratory (BNL). The water-cooled magnet designed with field strength of up to 0.7 Tesla will be used as a spectrometer in the Thompson scattering and vacuum acceleration experiments, where field-dependent electron scattering, beam focusing and energy spread will be analyzed. This magnet will deflect the ATF's 60 MeV electron-beam 90{sup o} downward, as a vertical beam dump for the Compton scattering experiment. The dipole magnet assembly is portable, and can be relocated to other beamlines at the ATF or other accelerator facilities to be used as a spectrometer or a beam dump. The mechanical and shielding calculations are presented in this paper. The structural rigidity and stability of the assembly were studied. A square lead shield surrounding the assembly's Faraday Cup was designed to attenuate the radiation emerging from the 1 inch-copper beam stop. All photons produced were assumed to be sufficiently energetic to generate photoneutrons. A safety evaluation of groundwater tritium contamination due to the thermal neutron capturing by the deuterium in water was performed, using updated Monte Carlo neutron-photon coupled transport code (MCNP). High-energy neutron spallation, which is a potential source to directly generate radioactive tritium and sodium-22 in soil, was conservatively assessed in verifying personal and environmental safety.

  12. The Summary for Optimization of the Annular Coupled Structure Accelerating Module Physical Design for High Intensity Hadron Linac

    CERN Document Server

    Paramonov, Valentin

    2013-01-01

    The normal conducting Annular Coupled Structure (ACS) is applied for 190-400 MeV part of high intensity proton linac for the J-PARC. The ACS operating frequency is 972 MHz. The J-PARC ACS is strongly based on the results of previous investigations, especially results of Japan Hadron Project (JHP) research program in KEK. However, the design was revised and optimized to meet the requirements of reliability, operation efficiency and cost reduction. The cells shape of accelerating cells was optimized in total energy range to have high shunt impedance value together with the careful matching with the decreased coupling cells. The design of the bridge coupler cells was optimized to simplify mass production and shape of RF input cell together with matching window were optimized for higher operational reliability. Collected and adjusted all together, these modifications result in the significant effect. The ACS module design doesn't lose to another possible accelerating structures in RF parameters and dimensions. Pr...

  13. Dynamic design, numerical solution and effective verification of acceleration-level obstacle-avoidance scheme for robot manipulators

    Science.gov (United States)

    Xiao, Lin; Zhang, Yunong

    2016-03-01

    For avoiding obstacles and joint physical constraints of robot manipulators, this paper proposes and investigates a novel obstacle avoidance scheme (termed the acceleration-level obstacle-avoidance scheme). The scheme is based on a new obstacle-avoidance criterion that is designed by using the gradient neural network approach for the first time. In addition, joint physical constraints such as joint-angle limits, joint-velocity limits and joint-acceleration limits are incorporated into such a scheme, which is further reformulated as a quadratic programming (QP). Two important 'bridge' theorems are established so that such a QP can be converted equivalently to a linear variational inequality and then equivalently to a piecewise-linear projection equation (PLPE). A numerical algorithm based on a PLPE is thus developed and applied for an online solution of the resultant QP. Four path-tracking tasks based on the PA10 robot in the presence of point and window-shaped obstacles demonstrate and verify the effectiveness and accuracy of the acceleration-level obstacle-avoidance scheme. Besides, the comparisons between the non-obstacle-avoidance and obstacle-avoidance results further validate the superiority of the proposed scheme.

  14. Mechanism of poly(acrylic acid) acceleration of antithrombin inhibition of thrombin: implications for the design of novel heparin mimics.

    Science.gov (United States)

    Monien, Bernhard H; Cheang, Kai I; Desai, Umesh R

    2005-08-11

    The bridging mechanism of antithrombin inhibition of thrombin is a dominant mechanism contributing a massive approximately 2500-fold acceleration in the reaction rate and is also a key reason for the clinical usage of heparin. Our recent study of the antithrombin-activating properties of a carboxylic acid-based polymer, poly(acrylic acid) (PAA), demonstrated a surprisingly high acceleration in thrombin inhibition (Monien, B. H.; Desai, U. R. J. Med. Chem. 2005, 48, 1269). To better understand this interesting phenomenon, we have studied the mechanism of PAA-dependent acceleration in antithrombin inhibition of thrombin. Competitive binding studies with low-affinity heparin and a heparin tetrasaccharide suggest that PAA binds antithrombin in both the pentasaccharide- and the extended heparin-binding sites, and these results are corroborated by molecular modeling. The salt-dependence of the K(D) of the PAA-antithrombin interaction shows the formation of five ionic interactions. In contrast, the contribution of nonionic forces is miniscule, resulting in an interaction that is significantly weaker than that observed for heparins. A bell-shaped profile of the observed rate constant for antithrombin inhibition of thrombin as a function of PAA concentration was observed, suggesting that inhibition proceeds through the "bridging" mechanism. The knowledge gained in this mechanistic study highlights important rules for the rational design of orally available heparin mimics. PMID:16078853

  15. Design of a beam shaping assembly and preliminary modelling of a treatment room for accelerator-based BNCT at CNEA

    Energy Technology Data Exchange (ETDEWEB)

    Burlon, A.A.; Girola, S. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina); Valda, A.A., E-mail: valda@tandar.cnea.gov.ar [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina); Minsky, D.M.; Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina)] [CONICET, Buenos Aires (Argentina); Sanchez, G. [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina)

    2011-12-15

    This work reports on the characterisation of a neutron beam shaping assembly (BSA) prototype and on the preliminary modelling of a treatment room for BNCT within the framework of a research programme for the development and construction of an accelerator-based BNCT irradiation facility in Buenos Aires, Argentina. The BSA prototype constructed has been characterised by means of MCNP simulations as well as a set of experimental measurements performed at the Tandar accelerator at the National Atomic Energy Commission of Argentina. - Highlights: Black-Right-Pointing-Pointer Characterisation of a neutron beam shaping assembly for accelerator-based BNCT. Black-Right-Pointing-Pointer Measurements: total and epi-cadmium neutron fluxes and beam homogeneity. Black-Right-Pointing-Pointer Calculations: Monte Carlo simulations with the MCNP code. Black-Right-Pointing-Pointer Measured and calculated figure-of-merit parameters in agreement with those of IAEA. Black-Right-Pointing-Pointer Initial MCNP dose calculations for a treatment room to define future design actions.

  16. Conceptual design of a 1013 -W pulsed-power accelerator for megajoule-class dynamic-material-physics experiments

    Science.gov (United States)

    Stygar, W. A.; Reisman, D. B.; Stoltzfus, B. S.; Austin, K. N.; Ao, T.; Benage, J. F.; Breden, E. W.; Cooper, R. A.; Cuneo, M. E.; Davis, J.-P.; Ennis, J. B.; Gard, P. D.; Greiser, G. W.; Gruner, F. R.; Haill, T. A.; Hutsel, B. T.; Jones, P. A.; LeChien, K. R.; Leckbee, J. J.; Lewis, S. A.; Lucero, D. J.; McKee, G. R.; Moore, J. K.; Mulville, T. D.; Muron, D. J.; Root, S.; Savage, M. E.; Sceiford, M. E.; Spielman, R. B.; Waisman, E. M.; Wisher, M. L.

    2016-07-01

    We have developed a conceptual design of a next-generation pulsed-power accelerator that is optimized for megajoule-class dynamic-material-physics experiments. Sufficient electrical energy is delivered by the accelerator to a physics load to achieve—within centimeter-scale samples—material pressures as high as 1 TPa. The accelerator design is based on an architecture that is founded on three concepts: single-stage electrical-pulse compression, impedance matching, and transit-time-isolated drive circuits. The prime power source of the accelerator consists of 600 independent impedance-matched Marx generators. Each Marx comprises eight 5.8-GW bricks connected electrically in series, and generates a 100-ns 46-GW electrical-power pulse. A 450-ns-long water-insulated coaxial-transmission-line impedance transformer transports the power generated by each Marx to a system of twelve 2.5-m-radius water-insulated conical transmission lines. The conical lines are connected electrically in parallel at a 66-cm radius by a water-insulated 45-post sextuple-post-hole convolute. The convolute sums the electrical currents at the outputs of the conical lines, and delivers the combined current to a single solid-dielectric-insulated radial transmission line. The radial line in turn transmits the combined current to the load. Since much of the accelerator is water insulated, we refer to it as Neptune. Neptune is 40 m in diameter, stores 4.8 MJ of electrical energy in its Marx capacitors, and generates 28 TW of peak electrical power. Since the Marxes are transit-time isolated from each other for 900 ns, they can be triggered at different times to construct-over an interval as long as 1 μ s -the specific load-current time history required for a given experiment. Neptune delivers 1 MJ and 20 MA in a 380-ns current pulse to an 18 -m Ω load; hence Neptune is a megajoule-class 20-MA arbitrary waveform generator. Neptune will allow the international scientific community to conduct dynamic

  17. Development of an accelerated test design for predicting the service life of the solar array at Mead, Nebraska. Quarterly report

    Energy Technology Data Exchange (ETDEWEB)

    Gaines, G.B.; Thomas, R.E.; Noel, G.T.; Shilliday, T.S.; Wood, V.E.; Carmichael, D.C.

    1979-02-06

    Economic viability requires that photovoltaic arrays should have a service life of 20 years or longer. Qualification and performance tests indicate that presently available photovoltaic modules provide acceptable performance at the time of installation. This study is being conducted as part of a program to develop and validate an accelerated test plan that can be used to predict the useful service life of present and future solar arrays. Previously a methodology was developed for designing an accelerated test program incorporating trade-offs between the cost of each test and its value in reducing the variance in the life prediction for that array. The objective of the present study is to apply this methodology to develop an accelerated test plan to predict the service life of the 25-kW photovoltaic array installed near Mead, Nebraska. Potential long-term degradation modes for the two types of modules in the Mead array have been determined and judgments have been made as to those environmental stresses and combinations of stresses which accelerate the degradation of the power output. Hierarchical trees representing the severity of effects of stresses (test conditions) on eleven individual degradation modes have been constructed and have been pruned of tests judged to be nonessential. Composites of those trees have been developed so that there is now one pruned tree covering eight degradation modes, another covering two degradation modes, and a third covering one degradation mode. These three composite trees form the basis for selection of test conditions in the final test plan which is now being prepared.

  18. Isothermal titration calorimetry: A thermodynamic interpretation of measurements

    International Nuclear Information System (INIS)

    Highlights: ► Literature review shows that many ITC utilizations are based on empirical rules. ► A proper and rigorous thermodynamic interpretation of heats of titration is proposed. ► Heats of titration are independent of the cell type using infinitesimal titrations. ► Heats of interaction between solutes require only two different titration runs. - Abstract: Isothermal titration calorimeters have been developed and in use since the 1960s and the number of applications based on empirical rules to use them steadily increases. In this paper a rigorous study of the physical interpretation of the titration heat and the thermodynamic framework underlying isothermal titration calorimetry are proposed. For infinitesimal titrations, the titration heat is independent of the cell type employed, and the interpretation of the titration heat depends on the titrant composition and on the experiment type. Moreover, for the study of the interaction between two solutes in solution, only a combination of two experiments is necessary, and the result is interpreted as the partial enthalpy of interaction at infinite dilution of the solute contained in the titrant solution.

  19. Methodology for designing accelerated aging tests for predicting life of photovoltaic arrays

    Science.gov (United States)

    Gaines, G. B.; Thomas, R. E.; Derringer, G. C.; Kistler, C. W.; Bigg, D. M.; Carmichael, D. C.

    1977-01-01

    A methodology for designing aging tests in which life prediction was paramount was developed. The methodology builds upon experience with regard to aging behavior in those material classes which are expected to be utilized as encapsulant elements, viz., glasses and polymers, and upon experience with the design of aging tests. The experiences were reviewed, and results are discussed in detail.

  20. Accelerator breeder nuclear fuel production: concept evaluation of a modified design for ORNL's proposed TME-ENFP

    International Nuclear Information System (INIS)

    Recent advances in accelerator beam technology have made it possible to improve the target/blanket design of the Ternary Metal Fueled Electronuclear Fuel Producer (TMF-ENFP), an accelerator-breeder design concept proposed by Burnss et al. for subcritical breeding of the fissile isotope 233U. In the original TMF-ENFP the 300-mA, 1100-MeV proton beam was limited to a small diameter whose power density was so high that a solid metal target could not be used for producing the spallation neutrons needed to drive the breeding process. Instead the target was a central column of circulating liquid sodium, which was surrounded by an inner multiplying region of ternary fuel rods (239Pu, 232Th, and 238U) and an outer blanket region of 232Th rods, with the entire system cooled by circulating sodium. In the modified design proposed here, the proton beam is sufficiently spread out to allow the ternary fuel to reside directly in the beam and to be preceded by a thin (nonstructural) V-Ti steel firThe spread beam mandated a change in the design configuration (from a cylindrical shape to an Erlenmeyer flask shape), which, in turn, required that the fuel rods (and blanket rods) be replaced by fuel pebbles. The fuel residence time in both systems was assumed to be 90 full power days. A series of parameter optimization calculations for the modified TMF-ENFP led to a semioptimized system in which the initial 239Pu inventory of the ternary fuel was 6% and the fuel pebble diameter was 0.5 cm. With this system the 233Pu production rate of 5.8 kg/day reported for the original TMF-ENFP was increased to 9.3 kg/day, and the thermal power production at beginning of cycle was increased from 3300 MW(t) to 5240 MW(t). 31 refs., 32 figs., 6 tabs

  1. ROXIE A Computer Code for the Integrated Design of Accelerator Magnets

    CERN Document Server

    Russenschuck, Stephan

    1998-01-01

    The paper describes the ROXIE software program package which has been developed for the design of the superconducting magnets for the LHC at CERN. The software is used as an approach towards the integrated design of superconducting magnets including feature-based coil geometry creation, conceptual design using genetic algorithms, optimization of the coil and iron cross-sections using a reduced vector-potential formulation, 3-D coil end geometry and field optimization using deterministic vector-optimization techniques, tolerance analysis, production of drawings by means of a DXF interface, end-spacer design with interfaces to CAD-CAM for the CNC machining of these pieces, and the tracing of manufacturing errors using field quality measurements.

  2. Isothermal titration calorimetry of ion-coupled membrane transporters.

    Science.gov (United States)

    Boudker, Olga; Oh, SeCheol

    2015-04-01

    Binding of ligands, ranging from proteins to ions, to membrane proteins is associated with absorption or release of heat that can be detected by isothermal titration calorimetry (ITC). Such measurements not only provide binding affinities but also afford direct access to thermodynamic parameters of binding--enthalpy, entropy and heat capacity. These parameters can be interpreted in a structural context, allow discrimination between different binding mechanisms and guide drug design. In this review, we introduce advantages and limitations of ITC as a methodology to study molecular interactions of membrane proteins. We further describe case studies where ITC was used to analyze thermodynamic linkage between ions and substrates in ion-coupled transporters. Similar type of linkage analysis will likely be applicable to a wide range of transporters, channels, and receptors.

  3. Workshop on CEBAF [Continuous Electron Beam Accelerator Facility] spectrometer magnet design and technology: Proceedings

    International Nuclear Information System (INIS)

    The planned experimental program at CEBAF includes high-resolution, large acceptance spectrometers and a large toroidal magnetic, detector. In order to take full advantage of the high quality beam characteristics, the performances required will make these devices quite unique instruments compared to existing facilities in the same energy range. Preliminary designs have shown that such performances can be reached, but key questions concerning design concepts and most appropriate and cost-effective technologies had to be answered before going further with the designs. It was the purpose of the Workshop on CEBAF Spectrometer Magnet Design and Technology, organized by the CEBAF Research and Engineering Divisions, to provide the most complete information about the state-of-the-art tools and techniques in magnet design and construction and to discuss the ones most appropriate to the CEBAF spectrometers. In addition, it is expected that this Workshop will be the staring point for further interactions and collaborations between international magnet experts and the CEBAF staff, during the whole process of designing and building the spectrometers

  4. KEKB accelerator

    International Nuclear Information System (INIS)

    KEKB, the B-Factory at High Energy Accelerator Research Organization (KEK) recently achieved the luminosity of 1 x 1034 cm-2s-1. This luminosity is two orders higher than the world's level at 1990 when the design of KEKB started. This unprecedented result was made possible by KEKB's innovative design and technology in three aspects - beam focusing optics, high current storage, and beam - beam interaction. Now KEKB is leading the luminosity frontier of the colliders in the world. (author)

  5. Research on Vertical Acceleration Design Response Spectrum%竖向加速度设计反应谱研究

    Institute of Scientific and Technical Information of China (English)

    高杰; 闫帅平; 陈振; 田琪凌; 冯程程

    2012-01-01

    鉴于我国《建筑抗震设计规范》( GB 50011-2010)未给出竖向加速度反应谱表达式这一现状,本文收集292组美国地区的强震记录,研究了各种地震环境下不同结构阻尼比对谱比取值(V/H)的影响,针对场地等单一影响因素统计得出谱比平均值并采用遗传算法进行最优拟合.以场地因素上的拟合谱比为基准谱比,考虑震中距、阻尼等因素取修正以建立各地震环境下的谱比建议式.应用我国10抗震规范中水平加速度反应谱表达式和本文的谱比建议式,本文列举了一个示例地震环境,并推导出竖向加速度设计反应谱建议式,研究成果可供我国抗震规范参考.%According to the situation that Chinese "Earthquake Resistant Design Code" ( GB50011-2010) does not rule the expression of vertical acceleration response spectrum, this paper collected hundreds of strong earthquake records in United States to study the influence of the factors such as seismic environment and structure damping ratio on the spectral ratio ( V/H). The authors selects some influencing factors which has a great impact on the spectral ratios and the regularity is good, including site conditions, epicentral distance and structural damping ratio. Based on genetic algorithm (GA) programming, the global optimum fitting results were researched. The fitted spectral ratio with impact of site condition as the datum spectral ratio is taken. Simultaneously, the impact of epicentral distance and damping ratio, was carried on the revision to the datum spectral ratio, thus the suggestion type of the spectral ratio under various earthquakes environment was established. Finally, the horizontal acceleration design response spectra was stipulated by current seismic design code of China and multiplied by the suggestion type of the spectral ratio from corresponding earthquake environment, then the suggestion type of the vertical acceleration design response spectra from this

  6. A full automatic device for sampling small solution volumes in photometric titration procedure based on multicommuted flow system.

    Science.gov (United States)

    Borges, Sivanildo S; Vieira, Gláucia P; Reis, Boaventura F

    2007-01-01

    In this work, an automatic device to deliver titrant solution into a titration chamber with the ability to determine the dispensed volume of solution, with good precision independent of both elapsed time and flow rate, is proposed. A glass tube maintained at the vertical position was employed as a container for the titrant solution. Electronic devices were coupled to the glass tube in order to control its filling with titrant solution, as well as the stepwise solution delivering into the titration chamber. The detection of the titration end point was performed employing a photometer designed using a green LED (lambda=545 nm) and a phototransistor. The titration flow system comprised three-way solenoid valves, which were assembled to allow that the steps comprising the solution container loading and the titration run were carried out automatically. The device for the solution volume determination was designed employing an infrared LED (lambda=930 nm) and a photodiode. When solution volume delivered from proposed device was within the range of 5 to 105 mul, a linear relationship (R = 0.999) between the delivered volumes and the generated potential difference was achieved. The usefulness of the proposed device was proved performing photometric titration of hydrochloric acid solution with a standardized sodium hydroxide solution and using phenolphthalein as an external indicator. The achieved results presented relative standard deviation of 1.5%. PMID:18317510

  7. Pre-design of MYRRHA, A Multipurpose Accelerator Driven System for Research and Development

    Science.gov (United States)

    D'hondt, P.; Abderrahim, H. Aït; Kupschus, P.; Malambu, E.; Aoust, Th.; Benoit, Ph.; Sobolev, V.; Van Tichelen, K.; Arien, B.; Vermeersch, F.; Jongen, Y.; Ternier, S.; Vandeplassche, D.

    2003-08-01

    One of the main SCK•CEN research facility, namely BR2, is nowadays arriving at an age of 40 years just like the major materials testing reactors (MTR) in the world and in Europe (i.e. BR2 (B-Mol), HFR (EU-Petten), OSIRIS (F-Saclay), R2 (S-Studsvik)). The MYRRHA facility in planning has been conceived as potentially replacing BR2 and to be a fast spectrum facility complementary to the thermal spectrum RJH (Réacteur Jules Horowitz) facility, in planning in France. This situation would give Europe a full research capability in terms of nuclear R&D. Furthermore, the disposal of radioactive wastes resulting from industrial nuclear energy production has still to find a fully satisfactory solution, especially in terms of environmental and social acceptability. Scientists are looking for ways to drastically reduce (by a factor of 100 or more) the radio-toxicity of the High Level Waste (HLW) to be stored in a deep geological repository. This can be achieved via burning of minor actinides (MA) and to a less extent of long-lived fission products (LLFP) in Accelerator Driven Systems. The MYRRHA project contribution will be in helping to demonstrate the ADS concept at reasonable power level and the demonstration of the technological feasibility of MA and LLFP transmutation under real conditions.

  8. Pre-design of MYRRHA, A Multipurpose Accelerator Driven System for Research and Development

    International Nuclear Information System (INIS)

    One of the main SCKCEN research facility, namely BR2, is nowadays arriving at an age of 40 years just like the major materials testing reactors (MTR) in the world and in Europe (i.e. BR2 (B-Mol), HFR (EU-Petten), OSIRIS (F-Saclay), R2 (S-Studsvik)). The MYRRHA facility in planning has been conceived as potentially replacing BR2 and to be a fast spectrum facility complementary to the thermal spectrum RJH (Reacteur Jules Horowitz) facility, in planning in France. This situation would give Europe a full research capability in terms of nuclear R and D. Furthermore, the disposal of radioactive wastes resulting from industrial nuclear energy production has still to find a fully satisfactory solution, especially in terms of environmental and social acceptability. Scientists are looking for ways to drastically reduce (by a factor of 100 or more) the radio-toxicity of the High Level Waste (HLW) to be stored in a deep geological repository. This can be achieved via burning of minor actinides (MA) and to a less extent of long-lived fission products (LLFP) in Accelerator Driven Systems. The MYRRHA project contribution will be in helping to demonstrate the ADS concept at reasonable power level and the demonstration of the technological feasibility of MA and LLFP transmutation under real conditions

  9. Preconceptual design of liquid metal targets with diaphragm for accelerator-based systems

    International Nuclear Information System (INIS)

    Preconceptual design of liquid lead-bismuth targets has been carried out for proton beam power 1-25 MW. The experience gained by SSCRF-IPPE and RDB 'Gidropress' in design, fabrication and exploitation of NNP with lead-bismuth was used in this design. The design of heat exchange equipment was developed in the form of integrated units including primary pumps, heat exchangers with Fild tubes, volume compensator. The comparative design was carried out with lead instead of lead-bismuth. This cause the diaphragm temperature 150 deg C higher than the one for lead-bismuth. The use of lead will require a lot of additional investigations of corrosion, mass transfer and coolant technology. Some results of thermohydraulic calculations are presented for velocity and temperature fields in the diaphragm area. These data were obtained using the SIMAX code, newly developed. The main technical parameters of liquid metal target for power 10 and 20 MW are presented. 2 refs., 3 figs., 1 tab

  10. Design and characterization of the DC acceleration and transport system required for the FOM 1 MW free electron maser experiment

    Energy Technology Data Exchange (ETDEWEB)

    Caplan, M. [Lawrence Livermore National Lab., CA (United States); Urbanus, W.H.; Geer, C. van der [FOM-Institut voor Plasma Fysica, Nieuwegein (Netherlands)] [and others

    1995-12-31

    A Free Electron Maser (FEM) has been constructed and is soon to be tested at the FOM Institute (Rijnhuizen) Netherlands with the goal of producing 1 MW long pulse to CW microwave output in the range 130 GHz to 250 GHz. The design uses a DC beam system in a depressed collector configuration in order to make the overall wall plug efficiency 50%. The high voltage ({approximately} 2 MeV) power supply provides only the body interception current ({approximately} 30 mA) while the 12 amp beam current is supplied by the 100-200 keV collector supplies. Some of the design features to ensure low interception current, which is critical to long pulse (CW) operation are: (1) DC beam in-line transport and acceleration system, (2) emittance conserving solenoid focusing system, (3) halo suppression techniques at cathode edge, and (4) very low beam fill factor (<20%). A relativistic version of the Herman Optical theory developed for microwave tubes is used to determine current distribution functions everywhere along the beam from the electron gun, through the DC accelerator and transport system to the wiggler. This theory takes into account thermals far out on the gaussian tail which translates into beam current far outside the ideal beam edge. This theory is applied to the FOM beam line design to predict a series of beam envelope contours containing various percentages of total beam current up to 99.9%. Predictions of body interception current due to finite emittance (effective temperature) are presented and compared with measured experimental results.

  11. Conceptual design for accelerator-driven sodium-cooled sub-critical transmutation reactors using scale laws

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwang Gu; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1998-12-31

    The feasibility study on conceptual design methodology for accelerator-driven sodium-cooled sub-critical transmutation reactors has been conducted to optimize the design parameters from the scale laws and validates the reactor performance with the integrated code system. A 1000 MWth sodium-cooled sub-critical transmutation reactor has been scaled and verified through the methodology in this paper, which is referred to Advanced Liquid Metal Reactor (ALMR). A Pb-Bi target material and a partitioned fuel are the liquid phases, and they are cooled by the circulation of secondary Pb-Bi coolant and by primary sodium coolant, respectively. Overall key design parameters are generated from the scale laws and they are improved and validated by the integrated code system. Integrated Code System (ICS) consists of LAHET, HMCNP, ORIGEN2, and COMMIX codes and some files. Through ICS the target region, the core region, and thermal-hydraulic related regions are analyzed once-through Results of conceptual design are attached in this paper. 5 refs., 4 figs., 1 tab. (Author)

  12. Design and Evaluation of a Clock Multiplexing Circuit for the SSRL Booster Accelerator Timing System - Oral Presentation

    Energy Technology Data Exchange (ETDEWEB)

    Araya, Million; /SLAC

    2015-08-25

    SPEAR3 is a 234 m circular storage ring at SLAC’s synchrotron radiation facility (SSRL) in which a 3 GeV electron beam is stored for user access. Typically the electron beam decays with a time constant of approximately 10hr due to electron lose. In order to replenish the lost electrons, a booster synchrotron is used to accelerate fresh electrons up to 3GeV for injection into SPEAR3. In order to maintain a constant electron beam current of 500mA, the injection process occurs at 5 minute intervals. At these times the booster synchrotron accelerates electrons for injection at a 10Hz rate. A 10Hz 'injection ready' clock pulse train is generated when the booster synchrotron is operating. Between injection intervalswhere the booster is not running and hence the 10 Hz ‘injection ready’ signal is not present-a 10Hz clock is derived from the power line supplied by Pacific Gas and Electric (PG&E) to keep track of the injection timing. For this project I constructed a multiplexing circuit to 'switch' between the booster synchrotron 'injection ready' clock signal and PG&E based clock signal. The circuit uses digital IC components and is capable of making glitch-free transitions between the two clocks. This report details construction of a prototype multiplexing circuit including test results and suggests improvement opportunities for the final design.

  13. Design and Evaluation of a Clock Multiplexing Circuit for the SSRL Booster Accelerator Timing System - Final Paper

    Energy Technology Data Exchange (ETDEWEB)

    Araya, Million

    2015-08-21

    SPEAR3 is a 234 m circular storage ring at SLAC’s synchrotron radiation facility (SSRL) in which a 3 GeV electron beam is stored for user access. Typically the electron beam decays with a time constant of approximately 10hr due to electron lose. In order to replenish the lost electrons, a booster synchrotron is used to accelerate fresh electrons up to 3GeV for injection into SPEAR3. In order to maintain a constant electron beam current of 500mA, the injection process occurs at 5 minute intervals. At these times the booster synchrotron accelerates electrons for injection at a 10Hz rate. A 10Hz 'injection ready' clock pulse train is generated when the booster synchrotron is operating. Between injection intervals-where the booster is not running and hence the 10 Hz ‘injection ready’ signal is not present-a 10Hz clock is derived from the power line supplied by Pacific Gas and Electric (PG&E) to keep track of the injection timing. For this project I constructed a multiplexing circuit to 'switch' between the booster synchrotron 'injection ready' clock signal and PG&E based clock signal. The circuit uses digital IC components and is capable of making glitch-free transitions between the two clocks. This report details construction of a prototype multiplexing circuit including test results and suggests improvement opportunities for the final design.

  14. Advanced accelerators

    International Nuclear Information System (INIS)

    This report discusses the suitability of four novel particle acceleration technologies for multi-TeV particle physics machines: laser driven linear accelerators (linac), plasma beat-wave devices, plasma wakefield devices, and switched power and cavity wakefield linacs. The report begins with the derivation of beam parameters practical for multi-TeV devices. Electromagnetic field breakdown of materials is reviewed. The two-beam accelerator scheme for using a free electron laser as the driver is discussed. The options recommended and the conclusions reached reflect the importance of cost. We recommend that more effort be invested in achieving a self-consistent range of TeV accelerator design parameters. Beat-wave devices have promise for 1-100 GeV applications and, while not directly scalable to TeV designs, the current generation of ideas are encouraging for the TeV regime. In particular, surfatrons, finite-angle optical mixing devices, plasma grating accelerator, and the Raman forward cascade schemes all deserve more complete analysis. The exploitation of standard linac geometry operated in an unconventional mode is in a phase of rapid evolution. While conceptual projects abound, there are no complete designs. We recommend that a fraction of sponsored research be devoted to this approach. Wakefield devices offer a great deal of potential; trades among their benefits and constraints are derived and discussed herein. The study of field limitation processes has received inadequate attention; this limits experiment designers. The costs of future experiments are such that investment in understanding these processes is prudent. 34 refs., 12 figs., 3 tabs

  15. Isothermal Titration Calorimetry to Characterize Enzymatic Reactions.

    Science.gov (United States)

    Mazzei, Luca; Ciurli, Stefano; Zambelli, Barbara

    2016-01-01

    Isothermal titration calorimetry (ITC) is a technique that measures the heat released or absorbed during a chemical reaction as an intrinsic probe to characterize any chemical process that involves heat changes spontaneously occurring during the reaction. The general features of this method to determine the kinetic and thermodynamic parameters of enzymatic reactions (kcat, KM, ΔH) are described and discussed here together with some detailed applications to specific cases. ITC does not require any modification or labeling of the system under analysis, can be performed in solution, and needs only small amounts of enzyme. These properties make ITC an invaluable, powerful, and unique tool to extend the knowledge of enzyme kinetics to drug discovery.

  16. Isothermal Titration Calorimetry of Chiral Polymeric Nanoparticles.

    Science.gov (United States)

    Werber, Liora; Preiss, Laura C; Landfester, Katharina; Muñoz-Espí, Rafael; Mastai, Yitzhak

    2015-09-01

    Chiral polymeric nanoparticles are of prime importance, mainly due to their enantioselective potential, for many applications such as catalysis and chiral separation in chromatography. In this article we report on the preparation of chiral polymeric nanoparticles by miniemulsion polymerization. In addition, we describe the use of isothermal titration calorimetry (ITC) to measure the chiral interactions and the energetics of the adsorption of enantiomers from aqueous solutions onto chiral polymeric nanoparticles. The characterization of chirality in nano-systems is a very challenging task; here, we demonstrate that ITC can be used to accurately determine the thermodynamic parameters associated with the chiral interactions of nanoparticles. The use of ITC to measure the energetics of chiral interactions and recognition at the surfaces of chiral nanoparticles can be applied to other nanoscale chiral systems and can provide further insight into the chiral discrimination processes of nanomaterials.

  17. Design, Implementation, and Test of a Multi-Model Systolic Neural-Network Accelerator

    Directory of Open Access Journals (Sweden)

    Thierry Cornu

    1996-01-01

    Full Text Available A multi-model neural-network computer has been designed and built. A compute-intensive application in the field of power-system monitoring, using the Kohonen neural network, has then been ported onto this machine. After a short description of the system, this article focuses on the programming paradigm adopted. The performance of the machine is also evaluated and discussed.

  18. IMPROVING THE DESIGN AND ANALYSIS OF SUPERCONDUCTING MAGNETS FOR PARTICLE ACCELERATORS

    Energy Technology Data Exchange (ETDEWEB)

    GUPTA,R.C.

    1996-11-01

    The field quality in superconducting magnets has been improved to a level that it does not appear to be a limiting factor on the performance of RHIC. The many methods developed, improved and adopted during the course of this work have contributed significantly to that performance. One can not only design and construct magnets with better field quality than in one made before but can also improve on that quality after construction. The relative field error ({Delta}B/B) can now be made as low as a few parts in 10{sup {minus}5} at 2/3 of the coil radius. This is about an order of magnitude better than what is generally expected for superconducting magnets. This extra high field quality is crucial to the luminosity performance of RHIC. The research work described here covers a number of areas which all must be addressed to build the production magnets with a high field quality. The work has been limited to the magnetic design of the cross section which in most cases essentially determines the field quality performance of the whole magnet since these magnets are generally long. Though the conclusions to be presented in this chapter have been discussed at the end of each chapter, a summary of them might be useful to present a complete picture. The lessons learned from these experiences may be useful in the design of new magnets. The possibilities of future improvements will also be presented.

  19. Optimum design of a moderator system based on dose calculation for an accelerator driven Boron Neutron Capture Therapy.

    Science.gov (United States)

    Inoue, R; Hiraga, F; Kiyanagi, Y

    2014-06-01

    An accelerator based BNCT has been desired because of its therapeutic convenience. However, optimal design of a neutron moderator system is still one of the issues. Therefore, detailed studies on materials consisting of the moderator system are necessary to obtain the optimal condition. In this study, the epithermal neutron flux and the RBE dose have been calculated as the indicators to look for optimal materials for the filter and the moderator. As a result, it was found that a combination of MgF2 moderator with Fe filter gave best performance, and the moderator system gave a dose ratio greater than 3 and an epithermal neutron flux over 1.0×10(9)cm(-2)s(-1).

  20. Basic design of shield blocks for a spallation neutron source under the high-intensity proton accelerator project

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Katsuhiko; Maekawa, Fujio; Takada, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    Under the JAERI-KEK High-Intensity Proton Accelerator Project (J-PARC), a spallation neutron source driven by a 3 GeV-1 MW proton beam is planed to be constructed as a main part of the Materials and Life Science Facility. Overall dimensions of a biological shield of the neutron source had been determined by evaluation of shielding performance by Monte Carlo calculations. This report describes results of design studies on an optimum dividing scheme in terms of cost and treatment and mechanical strength of shield blocks for the biological shield. As for mechanical strength, it was studied whether the shield blocks would be stable, fall down or move to a horizontal direction in case of an earthquake of seismic intensity of 5.5 (250 Gal) as an abnormal load. For ceiling shielding blocks being supported by both ends of the long blocks, maximum bending moment and an amount of maximum deflection of their center were evaluated. (author)

  1. Design study of small molten-salt fission power station suitable for coupling with accelerator molten-salt breeder

    International Nuclear Information System (INIS)

    A design study of /sup 233/U fueled 350 MWth(150MWe) molten-salt fission reactor was proceeded as an example of the economical utility facilities improving excellent inherent safety and easy operation and maintenance as follows (1) no exchange of core graphite resulting a sealed reactor vessel, (2) 99% removal of fission gases only and no continuous chemical processing, (3) very high conversion ratio such as 1.00 (fuel self-sufficient), (4) usefulness for the Trans-U incineration and the non-nuclear proliferation. Its low concentration of /sup 233/UF/sub 4/ will be significant for the symbiotic molten-salt fuel cycle with Accelerator Molten-Salt Breeder or the similiars

  2. Requirements for design of accelerator, beam transport, and target in a study of thermonuclear reaction cross section

    Energy Technology Data Exchange (ETDEWEB)

    Itahashi, T.; Takahisa, K.; Fujiwara, M.; Toki, H.; Ejiri, H. [Osaka Univ., Ibaraki (Japan). Research Center for Nuclear Physics; Ohsumi, H.; Komori, M.

    1997-03-01

    A compact accelerator with high current ion source, low energy beam transport elements and windowless gas target was designed to investigate the thermonuclear reaction cross section. The idea of this project focused on the cross section measurement of the fusion reaction data {sup 3}He+{sup 3}He-{sup 4}He+p+p at 25keV. The system will be installed in Otoh Cosmo Observatory (1270m.w.e.) to get rid of the huge cosmic and environmental background. It consists of NANOGUN ECR ion source, focusing elements made of permanent magnets window less {sup 3}He gas target and/or He{sup 3} plasma target and detector telescopes with low noise and low background. Requirements for these were discussed technically and various ideas were proposed. (author)

  3. Instrumentation and automated photometric titration procedure for total acidity determination in red wine employing a multicommuted flow system.

    Science.gov (United States)

    Garcia, Ausberta Jesus Cabezas; Reis, Boaventura F

    2006-01-01

    An automated procedure for photometric titration of red wine and associated instrumentation is described. The procedure was based on the flow-batch approach implemented employing multicommutation. The photometric detection was carried out using a homemade LED-based photometer. The mixing device, LED, and photodetector were attached to the titration chamber in order to form a compact and small-sized unit. The flow system comprised an automatic injector and three-way solenoid valves, which were controlled by a microcomputer through an electronic interface card. The software, written in Quick BASIC 4.5, was designed with abilities to accomplish all steps of the titration procedure including data acquisition and real-time processing to decide about the course of titration in the following step and so forth, until the titration endpoint was reached. The usefulness of the proposed titration system was demonstrated by analyzing red wine samples. When results were compared with those obtained using the AOAC reference method, no significant difference was observed at the 95% confidence level. A relative standard deviation of ca 2% (n=9) was obtained when processing a typical red wine sample containing 7.3 gl-1 total acidity expressed as tartaric acid. PMID:17671625

  4. A Closer Look at Acid-Base Olfactory Titrations

    Science.gov (United States)

    Neppel, Kerry; Oliver-Hoyo, Maria T.; Queen, Connie; Reed, Nicole

    2005-01-01

    Olfactory titrations using raw onions and eugenol as acid-base indicators are reported. An in-depth investigation on olfactory titrations is presented to include requirements for potential olfactory indicators and protocols for using garlic, onions, and vanillin as acid-base olfactory indicators are tested.

  5. The coulometric titration of acids and bases in dimethylsulfoxide media

    NARCIS (Netherlands)

    Bos, M.; IJpma, S.T.; Dahmen, E.A.M.F.

    1976-01-01

    The coulometric titration of 20–200 μeq of acids and bases in DMSO media is described. In the titration of bases, the electro-oxidation of hydrogen at a platinized platinum electrode is used as the source of protons. The conditions for 100 % current efficiency at this electrode are low current densi

  6. Microscale pH Titrations Using an Automatic Pipet.

    Science.gov (United States)

    Flint, Edward B.; Kortz, Carrie L.; Taylor, Max A.

    2002-01-01

    Presents a microscale pH titration technique that utilizes an automatic pipet. A small aliquot (1-5 mL) of the analyte solution is titrated with repeated additions of titrant, and the pH is determined after each delivery. The equivalence point is determined graphically by either the second derivative method or a Gran plot. The pipet can be…

  7. Coupled Mechanical-Electrochemical-Thermal Modeling for Accelerated Design of EV Batteries; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, Ahmad; Zhang, Chao; Kim, Gi-heon; Santhanagopalan, Shriram

    2015-06-10

    The physical and chemical phenomena occurring in a battery are many and complex and in many different scales. Without a better knowledge of the interplay among the multi-physics occurring across the varied scales, it is very challenging and time consuming to design long-lasting, high-performing, safe, affordable large battery systems, enabling electrification of the vehicles and modernization of the grid. The National Renewable Energy Laboratory, a U.S. Department of Energy laboratory, has been developing thermal and electrochemical models for cells and battery packs. Working with software producers, carmakers, and battery developers, computer-aided engineering tools have been developed that can accelerate the electrochemical and thermal design of batteries, reducing time to develop and optimize them and thus reducing the cost of the system. In the past couple of years, we initiated a project to model the mechanical response of batteries to stress, strain, fracture, deformation, puncture, and crush and then link them to electrochemical and thermal models to predict the response of a battery. This modeling is particularly important for understanding the physics and processes that happen in a battery during a crush-inducing vehicle crash. In this paper, we provide an overview of electrochemical-thermal-mechanical models for battery system understanding and designing.

  8. Design of an accelerated test to determine the attack of the sulphates on concrete structures, and the suggest alternative to design a container

    International Nuclear Information System (INIS)

    This work at demonstrating one of the accelerated tests in the frame of the Norm ASTM E-632-82, in order to evaluate the life of service for Reinforced Concrete Structures with High Performance.These will be used as barriers of engineering in containers for Radioactive Wastes.The results of the evaluation are necessary for the probabilistic and deterministic analysis, which are required to obtain licentiate for the emplacement and construction of this type of installations.Since concrete is the principal material used in this type of containers, its properties, in particular, its durability must be evaluated taking into accounts both, intrinsic factors and the extrinsic factors.Within the intrinsic factors we can mention your formulation, including design of armors of steel, production, treated and structural design.As extrinsic factors, weather and environmental, soil characteristic and service operation must be considered.It is important to emphasize that within the criteria used in the conceptual design of these types of repositories, the structures that act of barrier must not alter their insulation properties during all the period of service, which may be several hundreds of years.Although it is not possible to guarantee that repository's performance will not be altered throughout its time of service, the fact to obtain results of accelerated tests and the long term, it will enable us to estimate the durability of such structures, across the support of mathematical suitable models.The different stages which should be taken into account for the development of the evaluation tests, determining the relevant parameters to be considered in them and results obtained so far, are showing in this work

  9. Vacuum seals design and testing for a linear accelerator of the National Spallation Neutron Source

    Energy Technology Data Exchange (ETDEWEB)

    Z. Chen; C. Gautier; F. Hemez; N. K. Bultman

    2000-02-01

    Vacuum seals are very important to ensure that the Spallation Neutron Source (SNS) Linac has an optimum vacuum system. The vacuum joints between flanges must have reliable seals to minimize the leak rate and meet vacuum and electrical requirements. In addition, it is desirable to simplify the installation and thereby also simplify the maintenance required. This report summarizes an investigation of the metal vacuum seals that include the metal C-seal, Energized Spring seal, Helcoflex Copper Delta seal, Aluminum Delta seal, delta seal with limiting ring, and the prototype of the copper diamond seals. The report also contains the material certifications, design, finite element analysis, and testing for all of these seals. It is a valuable reference for any vacuum system design. To evaluate the suitability of several types of metal seals for use in the SNS Linac and to determine the torque applied on the bolts, a series of vacuum leak rate tests on the metal seals have been completed at Los Alamos Laboratory. A copper plated flange, using the same type of delta seal that was used for testing with the stainless steel flange, has also been studied and tested. A vacuum seal is desired that requires significantly less loading than a standard ConFlat flange with a copper gasket for the coupling cavity assembly. To save the intersegment space the authors use thinner flanges in the design. The leak rate of the thin ConFlat flange with a copper gasket is a baseline for the vacuum test on all seals and thin flanges. A finite element analysis of a long coupling cavity flange with a copper delta seal has been performed in order to confirm the design of the long coupling cavity flange and the welded area of a cavity body with the flange. This analysis is also necessary to predict a potential deformation of the cavity under the combined force of atmospheric pressure and the seating load of the seal. Modeling of this assembly has been achieved using both HKS/Abaqus and COSMOS

  10. Vacuum seals design and testing for a linear accelerator of the National Spallation Neutron Source

    International Nuclear Information System (INIS)

    Vacuum seals are very important to ensure that the Spallation Neutron Source (SNS) Linac has an optimum vacuum system. The vacuum joints between flanges must have reliable seals to minimize the leak rate and meet vacuum and electrical requirements. In addition, it is desirable to simplify the installation and thereby also simplify the maintenance required. This report summarizes an investigation of the metal vacuum seals that include the metal C-seal, Energized Spring seal, Helcoflex Copper Delta seal, Aluminum Delta seal, delta seal with limiting ring, and the prototype of the copper diamond seals. The report also contains the material certifications, design, finite element analysis, and testing for all of these seals. It is a valuable reference for any vacuum system design. To evaluate the suitability of several types of metal seals for use in the SNS Linac and to determine the torque applied on the bolts, a series of vacuum leak rate tests on the metal seals have been completed at Los Alamos Laboratory. A copper plated flange, using the same type of delta seal that was used for testing with the stainless steel flange, has also been studied and tested. A vacuum seal is desired that requires significantly less loading than a standard ConFlat flange with a copper gasket for the coupling cavity assembly. To save the intersegment space the authors use thinner flanges in the design. The leak rate of the thin ConFlat flange with a copper gasket is a baseline for the vacuum test on all seals and thin flanges. A finite element analysis of a long coupling cavity flange with a copper delta seal has been performed in order to confirm the design of the long coupling cavity flange and the welded area of a cavity body with the flange. This analysis is also necessary to predict a potential deformation of the cavity under the combined force of atmospheric pressure and the seating load of the seal. Modeling of this assembly has been achieved using both HKS/Abaqus and COSMOS

  11. Monte Carlo calculations for design of An accelerator based PGNAA facility

    International Nuclear Information System (INIS)

    Monte Carlo calculations were carried out for design of a set up for Prompt Gamma Ray Neutron Activation Analysis (PGNAA) by 14 MeV neutrons to analyze cement raw material samples. The calculations were carried out using code the MCNP4B2. Various geometry parameters of the PGNAA experimental setup such as sample thickness, moderator geometry and detector shielding etc were optimized by maximizing the prompt gamma ray yield of different elements of sample material. Finally calibration curve of the PGNAA setup were generated for various concentrations of calcium in the material sample. Results of this simulation are presented. (author)

  12. Monte Carlo calculations for design of An accelerator based PGNAA facility

    Energy Technology Data Exchange (ETDEWEB)

    Nagadi, M.M.; Naqvi, A.A. [King Fahd University of Petroleum and Minerals, Center for Applied Physical Sciences, Dhahran (Saudi Arabia); Rehman, Khateeb-ur; Kidwai, S. [King Fahd University of Petroleum and Minerals, Department of Physics, Dhahran (Saudi Arabia)

    2002-08-01

    Monte Carlo calculations were carried out for design of a set up for Prompt Gamma Ray Neutron Activation Analysis (PGNAA) by 14 MeV neutrons to analyze cement raw material samples. The calculations were carried out using code the MCNP4B2. Various geometry parameters of the PGNAA experimental setup such as sample thickness, moderator geometry and detector shielding etc were optimized by maximizing the prompt gamma ray yield of different elements of sample material. Finally calibration curve of the PGNAA setup were generated for various concentrations of calcium in the material sample. Results of this simulation are presented. (author)

  13. Design Study of Full Scale Accelerator Driven System (ADS, for Transmuting High Level Waste of MA/Pu

    Directory of Open Access Journals (Sweden)

    Marsodi

    2008-07-01

    Full Text Available The ADS system used in this study consisting of a high intensity proton linear accelerator, a spallation target, and a sub-critical reactor core. The Pb-Bi spallation target is bombarded by high intensity protons coming from the accelerator. The fast neutrons generated from the spallation reaction were used to drive the sub-critical reactor core. In this ADS system, the neutron source is in the center of reactor core region, so that the neutron distribution was concentrated in the center of core region. In this case, the B/T of MA/Pu could be performed effectively in the center of core region. The neutron energy in the outer region of reactor core was decreased due to the moderation of fuel and coolant materials. Such condition gives a chance to perform Burning and/or Transmutation of LLFPs.The basic parameters of this system are shown in the form of neutronic design, neutron spectrum and B/T rate, including other aspects related to the safety operation system. Furthermore, the analysis of the ADS system was accomplished using ATRAS computer code of the Japan Atomic Energy Research Institute, JAERI[1]. Due to the complexity of the reactor calculation codes, the author has carried out only those calculations needed for analyzing the neutronics system and some parameters related to the safety system. Design study of the transmutation system was a full-scale power level system of 657.53 MWt sub-critical reactor for an accelerator-driven transmutation system. The liquid Pb-Bi was used together as the spallation target materials and coolant of the system, because of some advantages of Pb-Bi in the system concerning the comparison with the sodium coolant. Moreover, they have a possibility to achieve a hard neutron energy spectrum, avoid a positive void reactivity coefficient, allow much lower system operating temperatures, and are favorable for safety in the event of coolant leakage. The multiplication factor of sub-critical core design was adjusted

  14. Design, construction and start up by Air Liquide of two 18 kW at 45 K helium refrigerators for the new CERN accelerator (LHC)

    CERN Document Server

    Dauguet, P; Delcayre, F; Ghisolfi, A; Gistau-Baguer, Guy M; Guerin, C A; Hilbert, B; Marot, G; Monneret, E

    2004-01-01

    CERN in Switzerland is presently building a new particle accelerator labeled as the LHC. This 27 km accelerator will, for the first time at such a large scale, operate at cryogenic temperatures with superconducting magnets and radio-frequency cavities. For that purpose, Air Liquide has designed, constructed and started up two custom designed refrigerators. The cryogenic power of each of these refrigerators is equivalent to 18 kW at 4.5 K. In order to produce the cryogenic power requested by the LHC accelerator at the different temperature levels with a very high efficiency, a custom design thermodynamic cycle has been chosen. This cycle, the major components of the refrigerators and the results obtained during the reception tests of the refrigerators are presented in this paper.

  15. A generalized approach for the calculation and automation of potentiometric titrations Part 1. Acid-Base Titrations

    NARCIS (Netherlands)

    Stur, J.; Bos, M.; Linden, van der W.E.

    1984-01-01

    Fast and accurate calculation procedures for pH and redox potentials are required for optimum control of automatic titrations. The procedure suggested is based on a three-dimensional titration curve V = f(pH, redox potential). All possible interactions between species in the solution, e.g., changes

  16. A new design of ion storage accelerator for time-of-flight-MS

    Energy Technology Data Exchange (ETDEWEB)

    Kraft, A.; Wollnik, H. [Justus-Liebig-Universitaet, Giessen (Germany); Laiko, V.; Dodonov, A.F. [Institute of Energy Problems of Chemical Physics, Chernogolovka (Russian Federation)

    1995-12-31

    A new Time-of-Flight MS for orthogonal extraction has been constructed. It consists of a API-source, the orthogonal extraction optic and a single stage reflectron as well as a detector with two MCP`s in Chevron-arrangement. The extraction optic has a new design in respect to the prevention of disturbing fields. Such fields take influence on the primary beam during accumulation made and causes noise as well as broadening of mass peaks. This fields arises from the penetration of field through the grid between the two stages of the extraction optic. In this construction, this penetration is compensated by the introduction of an additional electrode which is held at the average virtual potential of the separation grid. By adjusting all electrical parameters of the mass spectrometer (extraction-pulser, backplane of reflector, focussing optics) the peakwidth had been optimized. It has been shown the peakwidth strongly depends on the potential of the compensation electrode. The optimal value corresponds in good agreement with the calculated value (1.7V instead of 1.56V). In the case of Gramicidin S (m=1140) a resolving power of 2000 is achieved.

  17. Titration procedure for low ethoxylated nonionic surfactants

    Energy Technology Data Exchange (ETDEWEB)

    Buschmann, N. [Anorganisch-Chemisches Inst., Lehrstuhl fuer Analytische Chemie, Muenster Univ. (Germany); Huelskoetter, F. [Anorganisch-Chemisches Inst., Lehrstuhl fuer Analytische Chemie, Muenster Univ. (Germany)

    1997-01-01

    Highly lipophilic surfactants are frequently used as emulsifiers for preparing oil-in-water emulsions (e.g. coolants lubricants). Typical surfactants used for this purpose are low ethoxylated alcohols and ethoxylated alkylphenols. Due to the low degree of ethoxylation they cannot be analysed by conventional methods. The method described in this article is based on the introduction of an anionic group into the molecule by a derivatization reaction. The reaction product can be determined by conventional titration methods for anionic surfactants without any modification. The use of the new method for other nonionic surfactants like sorbitan esters, (ethoxylated) fatty acid amides or glycerol fatty acid partial esters is also described as well as the sample preparation for coolants lubricants. (orig.) [Deutsch] Lipophile Tenside werden haeufig zur Herstellung von Oel-in-Wasser-Emulsionen verwandt, wie sie beispielsweise in Kuehlschmiermitteln eingesetzt werden. Typische Vertreter dieser Tenside sind niedrig ethoxylierte Fettalkohole und Alkylphenole. Wegen ihres geringen Ethoxylierungsgrades koennen sie mit den konventionellen Methoden nicht analytisch bestimmt werden. Die hier beschriebene Analysenmethode beruht auf der Derivatisierung der Ethoxylate zu entsprechenden anionischen Tensiden (Ethersulfate). Diese koennen ohne weiteres mit den etablierten Titrationsverfahren bestimmt werden. Die Anwendung dieses neuen Verfahrens auf die Bestimmung anderer nichtionischer Tenside - Sorbitanester, (ethoxylierte) Fettsaeureamide und Partialglyceride - wird ebenso beschrieben wie die Probenvorbereitung fuer die Analyse von Kuehlschmiermitteln. (orig.)

  18. Titration and hysteresis in epigenetic chromatin silencing

    International Nuclear Information System (INIS)

    Epigenetic mechanisms of silencing via heritable chromatin modifications play a major role in gene regulation and cell fate specification. We consider a model of epigenetic chromatin silencing in budding yeast and study the bifurcation diagram and characterize the bistable and the monostable regimes. The main focus of this paper is to examine how the perturbations altering the activity of histone modifying enzymes affect the epigenetic states. We analyze the implications of having the total number of silencing proteins, given by the sum of proteins bound to the nucleosomes and the ones available in the ambient, to be constant. This constraint couples different regions of chromatin through the shared reservoir of ambient silencing proteins. We show that the response of the system to perturbations depends dramatically on the titration effect caused by the above constraint. In particular, for a certain range of overall abundance of silencing proteins, the hysteresis loop changes qualitatively with certain jump replaced by continuous merger of different states. In addition, we find a nonmonotonic dependence of gene expression on the rate of histone deacetylation activity of Sir2. We discuss how these qualitative predictions of our model could be compared with experimental studies of the yeast system under anti-silencing drugs. (paper)

  19. Automatic photometric titrations of calcium and magnesium in carbonate rocks

    Science.gov (United States)

    Shapiro, L.; Brannock, W.W.

    1955-01-01

    Rapid nonsubjective methods have been developed for the determination of calcium and magnesium in carbonate rocks. From a single solution of the sample, calcium is titrated directly, and magnesium is titrated after a rapid removal of R2O3 and precipitation of calcium as the tungstate. A concentrated and a dilute solution of disodium ethylenediamine tetraacetate are used as titrants. The concentrated solution is added almost to the end point, then the weak solution is added in an automatic titrator to determine the end point precisely.

  20. Laser-plasma acceleration with multi-color pulse stacks: Designer electron beams for advanced radiation sources

    Science.gov (United States)

    Kalmykov, Serge; Shadwick, Bradley; Ghebregziabher, Isaac; Davoine, Xavier

    2015-11-01

    Photon engineering offers new avenues to coherently control electron beam phase space on a femtosecond time scale. It enables generation of high-quality beams at a kHz-scale repetition rate. Reducing the peak pulse power (and thus the average laser power) is the key to effectively exercise such control. A stepwise negative chirp, synthesized by incoherently stacking collinear sub-Joule pulses from conventional CPA, affords a micron-scale bandwidth. It is sufficient to prevent rapid compression of the pulse into an optical shock, while delaying electron dephasing. This extends electron energy far beyond the limits suggested by accepted scalings (beyond 1 GeV in a 3 mm plasma), without compromising beam quality. In addition, acceleration with a stacked pulse in a channel favorably modifies electron beam on a femtosecond time scale, controllably producing synchronized sequences of 100 kA-scale, quasi-monoenergetic bunches. These comb-like, designer GeV electron beams are ideal drivers of polychromatic, tunable inverse Thomson γ-ray sources. The work of SYK and BAS is supported by the US DOE Grant DE-SC0008382 and NSF Grant PHY-1104683. Inverse Thomson scattering simulations were completed utilizing the Holland Computing Center of the University of Nebraska.

  1. Engineering design and development of shielding door and safety shutter for transfer line-3 tunnel of Indus accelerator complex

    International Nuclear Information System (INIS)

    Indus accelerator complex houses two synchrotron radiation sources, Indus-1 and Indus-2. Electron beam from booster synchrotron is injected into lndus-2 through transfer line-3 (TL-3). In order to reduce the radiation coming from TL-3 through the door opening to Indus-1, to safe limit, a sliding shielding door has been developed. It is a close welded frame of mild steel with required thickness of shielding material in the form of interlocking lead bricks stacked inside. The door is suspended from an overhead I-beam attached to welded wall brackets, which are fixed to RCC wall using anchor fasteners. Pneumatic drive is used for moving the door. Radiation measurements carried out after the installation show substantial reduction in the radiation field at Indus-1 experimental hall. Another safety concern is the inadvertent transmission of electron beam from booster synchrotron to TL-3. For this purpose a safety shutter has been made. It comprises of a beam absorber made of high density alloy DENSIMET which can be moved in and out of electron beam path. Design, fabrication, installation and testing of sliding shielding door and the beam shutter have been described. (author)

  2. The application of the Accelerated Stability Assessment Program (ASAP) to quality by design (QbD) for drug product stability.

    Science.gov (United States)

    Waterman, Kenneth Craig

    2011-09-01

    An isoconversion paradigm, where times in different temperature and humidity-controlled stability chambers are set to provide a fixed degradant level, is shown to compensate for the complex, non-single order kinetics of solid drug products. A humidity-corrected Arrhenius equation provides reliable estimates for temperature and relative humidity effects on degradation rates. A statistical protocol is employed to determine best fits for chemical stability data, which in turn allows for accurate estimations of shelf life (with appropriate confidence intervals) at any storage condition including inside packaging (based on the moisture vapor transmission rate of the packaging and moisture sorption isotherms of the internal components). These methodologies provide both faster results and far better predictions of chemical stability limited shelf life (expiry) than previously possible. Precise shelf-life estimations are generally determined using a 2-week, product-specific protocol. Once the model for a product is developed, it can play a critical role in providing the product understanding necessary for a quality by design (QbD) filing for product approval and enable rational control strategies to assure product stability. Moreover, this Accelerated Stability Assessment Program (ASAP) enables the coupling of product attributes (e.g., moisture content, packaging options) to allow for flexibility in how control strategies are implemented to provide a balance of cost, speed, and other factors while maintaining adequate stability. PMID:21748541

  3. Requirements for design of accelerator, beam transport, and target in a study of thermonuclear reaction cross section

    Energy Technology Data Exchange (ETDEWEB)

    Itahashi, T.; Takahisa, K.; Ohsumi, H.; Komori, M.; Fujiwara, M.; Toki, H. [Osaka Univ., Suita (Japan)

    1997-02-01

    The process of pp-de{sup +}{nu} is the basic fusion reaction for hydrogen burning in the sun and the prime reaction in chain producing photons and neutrinos. There are many works of the theoretical estimation of the reaction rate in the reaction chain in the sun. The precise measurement of the nutrinos from the sun is one of the most important current physics issues. The rate of the pp-de{sup +}{nu} is too small to be measured in laboratories. The construction of a compact ion accelerator facility with high current, low energy transport and plasma target is planned at the underground laboratory in Otoh Cosmo Observatory of Research Center for Nuclear Physics. The plasma target by using the EBIS type synthesized plasma was proposed as a bare {sup 3}He target. The production of helium ions of each charge state was tested by using the present NEOMAFIOS ECR ion source, and the obtained current is shown. For noncontaminated, high current beam transport, the strong focusing system was introduced. The design of windowless gas target, plasma target, the detection of the energetic reaction particles of protons, digital calorimeter, the couple of ECR ion source and plasma target, and the underground laboratory are reported. (K.I.)

  4. Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.

    Science.gov (United States)

    Miao, Yinglong; Goldfeld, Dahlia Anne; Moo, Ee Von; Sexton, Patrick M; Christopoulos, Arthur; McCammon, J Andrew; Valant, Celine

    2016-09-20

    Design of ligands that provide receptor selectivity has emerged as a new paradigm for drug discovery of G protein-coupled receptors, and may, for certain families of receptors, only be achieved via identification of chemically diverse allosteric modulators. Here, the extracellular vestibule of the M2 muscarinic acetylcholine receptor (mAChR) is targeted for structure-based design of allosteric modulators. Accelerated molecular dynamics (aMD) simulations were performed to construct structural ensembles that account for the receptor flexibility. Compounds obtained from the National Cancer Institute (NCI) were docked to the receptor ensembles. Retrospective docking of known ligands showed that combining aMD simulations with Glide induced fit docking (IFD) provided much-improved enrichment factors, compared with the Glide virtual screening workflow. Glide IFD was thus applied in receptor ensemble docking, and 38 top-ranked NCI compounds were selected for experimental testing. In [(3)H]N-methylscopolamine radioligand dissociation assays, approximately half of the 38 lead compounds altered the radioligand dissociation rate, a hallmark of allosteric behavior. In further competition binding experiments, we identified 12 compounds with affinity of ≤30 μM. With final functional experiments on six selected compounds, we confirmed four of them as new negative allosteric modulators (NAMs) and one as positive allosteric modulator of agonist-mediated response at the M2 mAChR. Two of the NAMs showed subtype selectivity without significant effect at the M1 and M3 mAChRs. This study demonstrates an unprecedented successful structure-based approach to identify chemically diverse and selective GPCR allosteric modulators with outstanding potential for further structure-activity relationship studies. PMID:27601651

  5. Advances in conceptual design of a gas-cooled accelerator driven system (ADS) transmutation devices to sustainable nuclear energy development

    International Nuclear Information System (INIS)

    The possibilities of a nuclear energy development are considerably increasing with the world energetic demand increment. However, the management of nuclear waste from conventional nuclear power plants and its inventory minimization are the most important issues that should be addressed. Fast reactors and Accelerator Driven Systems (ADS) are the main options to reduce the long-lived radioactive waste inventory. Pebble Bed Very High Temperature advanced systems have great perspectives to assume the future nuclear energy development challenges. The conceptual design of a Transmutation Advanced Device for Sustainable Energy Applications (TADSEA) has been made in preliminary studies. The TADSEA is an ADS cooled by helium and moderated by graphite that uses as fuel small amounts of transuranic elements in the form of TRISO particles, confined in 3 cm radius graphite pebbles forming a pebble bed configuration. It would be used for nuclear waste transmutation and energy production. In this paper, the results of a method for calculating the number of whole pebbles fitting in a volume according to its size are showed. From these results, the packing fraction influence on the TADSEAs main work parameters is studied. In addition, a redesign of the previous configuration, according to the established conditions in the preliminary design, i.e. the exit thermal power, is made. On the other hand, the heterogeneity of the TRISO particles inside the pebbles can not be negligible. In this paper, a study of the power density distribution inside the pebbles by means of a detailed simulation of the TRISO fuel particles and using an homogeneous composition of the fuel is addressed. (author)

  6. Analysis of the Purity of Cetrimide by Titrations

    DEFF Research Database (Denmark)

    Andersen, Jens Enevold Thaulov; Rasmussen, Claus/Dallerup; Nielsen, Hans/Boye

    2006-01-01

    The purity of cetrimide, trimethyl tetradecyl ammonium bromide (TTAB), that is an important preservative of many cosmetic and pharmaceutical products, was determined by three independent methods of titration. Traditionally, cetrimide was analysed by an assay method of the European Pharmacopoeia (Ph....... Eur.), which showed consistently a low purity of cetrimide with large standard deviations associated, however. A systematic 3% bias of the Ph. Eur. assay method was identified by comparing the result with results of two alternative methods of titration that exhibited high precision and high accuracy....... Titration by perchloric acid showed a 99.69 ± 0.05 % purity of cetrimide and titration by silver nitrate showed a 99.85% ± 0.05 % purity while the traditional assay method predicted a purity of only 97.1 ± 0.4. It was found that the discrepancy could be identified as differences in selectivity during...

  7. A microcomputer-controlled system for titration analysis

    NARCIS (Netherlands)

    Boelema, Gerrit Jan

    1982-01-01

    This thesis deals with the results of the implementation of microprocessor technology in automatic titration equipment to obtain a versatile system for pharmaceutical, chemical analytical and optimization research purposes. ... Zie: Summary

  8. Implementation and assessment of a computerized potentiometric titration

    International Nuclear Information System (INIS)

    Potentiometric titrations still have a great importance in the work of chemical analysis laboratories of different nature, as well as in the Chemistry programs or related to this discipline. At the same time, such titrations have been frequently criticized as tedious and arduous. At our laboratories, potentiometric titrations are important to determine the performance of several radiochemical separations and as a complement to the nuclear techniques in some analysis. Due to the automatic potentiometric titrations high-cost, some authors have proposed some relatively low-cost alternatives that may be built or implemented in research, services or instruction analytical laboratories. This work describes a controlled system by computer, developed and used at the Chemical Department laboratories of the General Direction of Promotion and Technological Development of IPEN

  9. Microscope Titration and Extraction of DNA from Liver.

    Science.gov (United States)

    Mayo, Lois T.; And Others

    1993-01-01

    Describes a simple and inexpensive, one-period activity to extract DNA to make the study of DNA less abstract. A microscope titration is used to determine when cells are ready for DNA extraction. (PR)

  10. A Titration Technique for Demonstrating a Magma Replenishment Model.

    Science.gov (United States)

    Hodder, A. P. W.

    1983-01-01

    Conductiometric titrations can be used to simulate subduction-setting volcanism. Suggestions are made as to the use of this technique in teaching volcanic mechanisms and geochemical indications of tectonic settings. (JN)

  11. Reliability of home CPAP titration with different automatic CPAP devices

    OpenAIRE

    Lacasse Yves; Plante Julie; Sériès Frédéric

    2008-01-01

    Abstract Background CPAP titration may be completed by automatic apparatus. However, differences in pressure behaviour could interfere with the reliability of pressure recommendations. Our objective was to compare pressure behaviour and effective pressure recommendations between three Automatic CPAP machines (Autoset Spirit, Remstar Auto, GK 420). Methods Sixteen untreated obstructive sleep apnea patients were randomly allocated to one of the 3 tested machines for a one-week home titration tr...

  12. Accelerator Technology Division

    Science.gov (United States)

    1992-04-01

    In fiscal year (FY) 1991, the Accelerator Technology (AT) division continued fulfilling its mission to pursue accelerator science and technology and to develop new accelerator concepts for application to research, defense, energy, industry, and other areas of national interest. This report discusses the following programs: The Ground Test Accelerator Program; APLE Free-Electron Laser Program; Accelerator Transmutation of Waste; JAERI, OMEGA Project, and Intense Neutron Source for Materials Testing; Advanced Free-Electron Laser Initiative; Superconducting Super Collider; The High-Power Microwave Program; (Phi) Factory Collaboration; Neutral Particle Beam Power System Highlights; Accelerator Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Accelerator Design and Engineering; Radio-Frequency Technology; Free-Electron Laser Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operations.

  13. Accelerator and radiation physics

    CERN Document Server

    Basu, Samita; Nandy, Maitreyee

    2013-01-01

    "Accelerator and radiation physics" encompasses radiation shielding design and strategies for hadron therapy accelerators, neutron facilities and laser based accelerators. A fascinating article describes detailed transport theory and its application to radiation transport. Detailed information on planning and design of a very high energy proton accelerator can be obtained from the article on radiological safety of J-PARC. Besides safety for proton accelerators, the book provides information on radiological safety issues for electron synchrotron and prevention and preparedness for radiological emergencies. Different methods for neutron dosimetry including LET based monitoring, time of flight spectrometry, track detectors are documented alongwith newly measured experimental data on radiation interaction with dyes, polymers, bones and other materials. Design of deuteron accelerator, shielding in beam line hutches in synchrotron and 14 MeV neutron generator, various radiation detection methods, their characteriza...

  14. The Accelerator Reliability Forum

    CERN Document Server

    Lüdeke, Andreas; Giachino, R

    2014-01-01

    A high reliability is a very important goal for most particle accelerators. The biennial Accelerator Reliability Workshop covers topics related to the design and operation of particle accelerators with a high reliability. In order to optimize the over-all reliability of an accelerator one needs to gather information on the reliability of many different subsystems. While a biennial workshop can serve as a platform for the exchange of such information, the authors aimed to provide a further channel to allow for a more timely communication: the Particle Accelerator Reliability Forum [1]. This contribution will describe the forum and advertise it’s usage in the community.

  15. Competitive counterion complexation allows the true host : guest binding constants from a single titration by ionic receptors.

    Science.gov (United States)

    Pessêgo, Márcia; Basílio, Nuno; Muñiz, M Carmen; García-Río, Luis

    2016-07-01

    Counterion competitive complexation is a background process currently ignored by using ionic hosts. Consequently, guest binding constants are strongly affected by the design of the titration experiments in such a way that the results are dependent on the guest concentration and on the presence of added salts, usually buffers. In the present manuscript we show that these experimental difficulties can be overcome by just considering the counterion competitive complexation. Moreover a single titration allows us to obtain not only the true binding constants but also the stoichiometry of the complex showing the formation of 1 : 1 : 1 (host : guest : counterion) complexes. The detection of high stoichiometry complexes is not restricted to a single titration experiment but also to a displacement assay where both competitive and competitive-cooperative complexation models are taken into consideration. PMID:27278457

  16. QUANTITATION OF DNA TOPOISOMERASE-II-ALPHA MESSENGER-RIBONUCLEIC-ACID LEVELS IN A SMALL-CELL LUNG-CANCER CELL-LINE AND 2 DRUG-RESISTANT SUBLINES USING A POLYMERASE CHAIN REACTION-AIDED TRANSCRIPT TITRATION ASSAY

    NARCIS (Netherlands)

    WITHOFF, S; SMIT, EF; MEERSMA, GJ; van den Berg, Anke; TIMMERBOSSCHA, H; KOK, K; POSTMUS, PE; MULDER, NH; DEVRIES, EGE; BUYS, CHCM

    1994-01-01

    BACKGROUND: We have modified a polymerase chain reaction (PCR)-aided transcript titration assay (1) in order to allow quantitation of low amounts of DNA topoisomerase II alpha mRNA in small RNA samples. EXPERIMENTAL DESIGN: The titration assay was used to quantitate the amount of DNA topoisomerase I

  17. Linear Accelerators

    CERN Document Server

    Vretenar, M

    2014-01-01

    The main features of radio-frequency linear accelerators are introduced, reviewing the different types of accelerating structures and presenting the main characteristics aspects of linac beam dynamics.

  18. American National Standards Institute ANSI N 43.1 Radiological Safety in the Design and Operation of Particle Accelerators

    International Nuclear Information System (INIS)

    The ANSI N43 committee established a writing committee to re-write the ANSI N43.1 accelerator safety standard in 1994. James Liu and Scott Walker were appointed as co-chairman. Compared to the old standard, the new standard is aimed to have a broader application, up-to-date requirements, and recommendations for best practices. The new standard uses a hazard based graded approach to address radiation safety programs for accelerators with various energies, beam currents and applications (excluding medical accelerators which are covered by another standard). Thus, the standard fulfills the goal of the committee to prepare a standard with unlimited application to industrial and research accelerators. The standard is largely complete with chapters as follows: 1) Scope. 2) Definitions. 3) Radiation Safety Program (facility safety program, radiation safety planning, organizational considerations, safety assessment, review and performance evaluation). 4) Radiation Safety System (prompt radiation, safety system features, reliability and fail-safety, tamper resistance, quality control, configuration control, adventitious production of radiation, and induced radioactivity). 5) Personnel Access Control System (including graded approach, postings, barriers, beam inhibiting devices and interlocks). 6) Radiation Control System, (passive shielding, and active systems). 7) Accelerator Operation (including readiness reviews, maintenance and testing, bypasses and deviation from procedure, operating practices, emergencies). 8) Operational Health Physics, and 9) Training. The document also has appendices regarding how to determine the Safety and Operations Envelope, Guidance for Computer Based Access Control Systems, and Radiation Measurements at Accelerators. (Author)

  19. Induction linear accelerators

    Science.gov (United States)

    Birx, Daniel

    1992-03-01

    Among the family of particle accelerators, the Induction Linear Accelerator is the best suited for the acceleration of high current electron beams. Because the electromagnetic radiation used to accelerate the electron beam is not stored in the cavities but is supplied by transmission lines during the beam pulse it is possible to utilize very low Q (typicallymarriage of liner accelerator technology and nonlinear magnetic compressors has produced some unique capabilities. It now appears possible to produce electron beams with average currents measured in amperes, peak currents in kiloamperes and gradients exceeding 1 MeV/meter, with power efficiencies approaching 50%. The nonlinear magnetic compression technology has replaced the spark gap drivers used on earlier accelerators with state-of-the-art all-solid-state SCR commutated compression chains. The reliability of these machines is now approaching 1010 shot MTBF. In the following paper we will briefly review the historical development of induction linear accelerators and then discuss the design considerations.

  20. Accelerator reliability workshop

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, L.; Duru, Ph.; Koch, J.M.; Revol, J.L.; Van Vaerenbergh, P.; Volpe, A.M.; Clugnet, K.; Dely, A.; Goodhew, D

    2002-07-01

    About 80 experts attended this workshop, which brought together all accelerator communities: accelerator driven systems, X-ray sources, medical and industrial accelerators, spallation sources projects (American and European), nuclear physics, etc. With newly proposed accelerator applications such as nuclear waste transmutation, replacement of nuclear power plants and others. Reliability has now become a number one priority for accelerator designers. Every part of an accelerator facility from cryogenic systems to data storage via RF systems are concerned by reliability. This aspect is now taken into account in the design/budget phase, especially for projects whose goal is to reach no more than 10 interruptions per year. This document gathers the slides but not the proceedings of the workshop.

  1. Accelerator reliability workshop

    International Nuclear Information System (INIS)

    About 80 experts attended this workshop, which brought together all accelerator communities: accelerator driven systems, X-ray sources, medical and industrial accelerators, spallation sources projects (American and European), nuclear physics, etc. With newly proposed accelerator applications such as nuclear waste transmutation, replacement of nuclear power plants and others. Reliability has now become a number one priority for accelerator designers. Every part of an accelerator facility from cryogenic systems to data storage via RF systems are concerned by reliability. This aspect is now taken into account in the design/budget phase, especially for projects whose goal is to reach no more than 10 interruptions per year. This document gathers the slides but not the proceedings of the workshop

  2. Potentiometric titration and equivalent weight of humic acid

    Science.gov (United States)

    Pommer, A.M.; Breger, I.A.

    1960-01-01

    The "acid nature" of humic acid has been controversial for many years. Some investigators claim that humic acid is a true weak acid, while others feel that its behaviour during potentiometric titration can be accounted for by colloidal adsorption of hydrogen ions. The acid character of humic acid has been reinvestigated using newly-derived relationships for the titration of weak acids with strong base. Re-interpreting the potentiometric titration data published by Thiele and Kettner in 1953, it was found that Merck humic acid behaves as a weak polyelectrolytic acid having an equivalent weight of 150, a pKa of 6.8 to 7.0, and a titration exponent of about 4.8. Interdretation of similar data pertaining to the titration of phenol-formaldehyde and pyrogallol-formaldehyde resins, considered to be analogs for humic acid by Thiele and Kettner, leads to the conclusion that it is not possible to differentiate between adsorption and acid-base reaction for these substances. ?? 1960.

  3. Design and implementation of a Client-Server System for Acquiring Beam Intensity Data from High Energy Accelerators at CERN

    CERN Document Server

    Topaloudis, A; Bellas, N; Jensen, L

    The world’s largest research center in the domain of High Energy Physics (HEP) is the European Organization for Nuclear Research (CERN) whose main goal is to accelerate particles through a sequence of acceleratorsaccelerator complex – and bring them into collision in order to study the fundamental elements of matter and the forces acting between them. For controlling the accelerator complex, CERN needs several diagnostic tools to provide information about the beam’s attributes and one such system is the Fast Beam Current Transformer (FBCT) measuring system that provides bunch-by-bunch and total beam intensity information. The current hardware and firmware of the FBCT system has certain issues and lacks diagnostics as a lot of the calculations are done in an FPGA. In order to improve on this, the firmware was redesigned and simplified in order to increase its capabilities and provide the base of a unified FBCT measuring system that could be installed in several of CERN’s accelerator complex’s pa...

  4. High-throughput Titration of Luciferase-expressing Recombinant Viruses

    OpenAIRE

    Garcia, Vanessa; Krishnan, Ramya; Davis, Colin; Batenchuk, Cory; Le Boeuf, Fabrice; Abdelbary, Hesham; Diallo, Jean-Simon

    2014-01-01

    Standard plaque assays to determine infectious viral titers can be time consuming, are not amenable to a high volume of samples, and cannot be done with viruses that do not form plaques. As an alternative to plaque assays, we have developed a high-throughput titration method that allows for the simultaneous titration of a high volume of samples in a single day. This approach involves infection of the samples with a Firefly luciferase tagged virus, transfer of the infected samples onto an appr...

  5. Preliminary design report of a relativistic-Klystron two-beam-accelerator based power source for a 1 TeV center-of-mass next linear collider

    Energy Technology Data Exchange (ETDEWEB)

    Yu, S.; Goffeney, N.; Henestroza, E. [Lawrence Berkeley Lab., CA (United States)] [and others

    1995-02-22

    A preliminary point design for an 11.4 GHz power source for a 1 TeV center-of-mass Next Linear Collider (NLC) based on the Relativistic-Klystron Two-Beam-Accelerator (RK-TBA) concept is presented. The present report is the result of a joint LBL-LLNL systems study. consisting of three major thrust areas: physics, engineering, and costing. The new RK-TBA point design, together with our findings in each of these areas, are reported.

  6. Preliminary design report of a relativistic-Klystron two-beam-accelerator based power source for a 1 TeV center-of-mass next linear collider

    International Nuclear Information System (INIS)

    A preliminary point design for an 11.4 GHz power source for a 1 TeV center-of-mass Next Linear Collider (NLC) based on the Relativistic-Klystron Two-Beam-Accelerator (RK-TBA) concept is presented. The present report is the result of a joint LBL-LLNL systems study. consisting of three major thrust areas: physics, engineering, and costing. The new RK-TBA point design, together with our findings in each of these areas, are reported

  7. "Titration simulator"--Good assistant for titration analysis%滴定分析教学的好帮手"Titration simulator"

    Institute of Scientific and Technical Information of China (English)

    屠婕红

    2005-01-01

    @@ Titration simulator(滴定模拟器)软件是专门为滴定分析而设计的教学软件,它短小精悍,简洁实用,可以从Internet网上免费下载,网址为:http://www.chemonline.net/Truechemsoft/downsoft.asp?softID=1565该软件所占容量仅为72KB,是学生训练及化学教师的好助手.笔者在教学中尝试运用该软件辅助教学,效果良好,现将Titration simulator软件的主要功能、应用简要介绍如下:

  8. Design of a 5-MA 100-ns linear-transformer-driver accelerator for wire array Z-pinch experiments

    Science.gov (United States)

    Zhou, Lin; Li, Zhenghong; Wang, Zhen; Liang, Chuan; Li, Mingjia; Qi, Jianmin; Chu, Yanyun

    2016-03-01

    The linear-transformer-driver (LTD) is a recently developed pulsed-power technology that shows great promise for a number of applications. These include a Z -pinch-driven fission-fusion-hybrid reactor that is being developed by the Chinese Academy of Engineering Physics. In support of the reactor development effort, we are planning to build an LTD-based accelerator that is optimized for driving wire-array Z -pinch loads. The accelerator comprises six modules in parallel, each of which has eight series 0.8-MA LTD cavities in a voltage-adder configuration. Vacuum transmission lines are used from the interior of the adder to the central vacuum chamber where the load is placed. Thus the traditional stack-flashover problem is eliminated. The machine is 3.2 m tall and 12 m in outer diameter including supports. A prototype cavity was built and tested for more than 6000 shots intermittently at a repetition rate of 0.1 Hz. A novel trigger, in which only one input trigger pulse is needed by utilizing an internal trigger brick, was developed and successfully verified in these shots. A full circuit modeling was conducted for the accelerator. The simulation result shows that a current pulse rising to 5.2 MA in 91 ns (10%-90%) can be delivered to the wire-array load, which is 1.5 cm in height, 1.2 cm in initial radius, and 1 mg in mass. The maximum implosion velocity of the load is 32 cm /μ s when compressed to 0.1 of the initial radius. The maximum kinetic energy is 78 kJ, which is 11.7% of the electric energy stored in the capacitors. This accelerator is supposed to enable a radiation energy efficiency of 20%-30%, providing a high efficient facility for research on the fast Z pinch and technologies for repetition-rate-operated accelerators.

  9. Switched Matrix Accelerator

    International Nuclear Information System (INIS)

    We describe a new concept for a microwave circuit functioning as a charged-particle accelerator at mm-wavelengths, permitting an accelerating gradient higher than conventional passive circuits can withstand consistent with cyclic fatigue. The device provides acceleration for multiple bunches in parallel channels, and permits a short exposure time for the conducting surface of the accelerating cavities. Our analysis includes scalings based on a smooth transmission line model and a complementary treatment with a coupled-cavity simulation. We provide also an electromagnetic design for the accelerating structure, arriving at rough dimensions for a seven-cell accelerator matched to standard waveguide and suitable for bench tests at low power in air at 91.392. GHz. A critical element in the concept is a fast mm-wave switch suitable for operation at high-power, and we present the considerations for implementation in an H-plane tee. We discuss the use of diamond as the photoconductor switch medium

  10. Particle-accelerator decommissioning

    International Nuclear Information System (INIS)

    Generic considerations involved in decommissioning particle accelerators are examined. There are presently several hundred accelerators operating in the United States that can produce material containing nonnegligible residual radioactivity. Residual radioactivity after final shutdown is generally short-lived induced activity and is localized in hot spots around the beam line. The decommissioning options addressed are mothballing, entombment, dismantlement with interim storage, and dismantlement with disposal. The recycle of components or entire accelerators following dismantlement is a definite possibility and has occurred in the past. Accelerator components can be recycled either immediately at accelerator shutdown or following a period of storage, depending on the nature of induced activation. Considerations of cost, radioactive waste, and radiological health are presented for four prototypic accelerators. Prototypes considered range from small accelerators having minimal amounts of radioactive mmaterial to a very large accelerator having massive components containing nonnegligible amounts of induced activation. Archival information on past decommissionings is presented, and recommendations concerning regulations and accelerator design that will aid in the decommissioning of an accelerator are given

  11. Particle-accelerator decommissioning

    Energy Technology Data Exchange (ETDEWEB)

    Opelka, J.H.; Mundis, R.L.; Marmer, G.J.; Peterson, J.M.; Siskind, B.; Kikta, M.J.

    1979-12-01

    Generic considerations involved in decommissioning particle accelerators are examined. There are presently several hundred accelerators operating in the United States that can produce material containing nonnegligible residual radioactivity. Residual radioactivity after final shutdown is generally short-lived induced activity and is localized in hot spots around the beam line. The decommissioning options addressed are mothballing, entombment, dismantlement with interim storage, and dismantlement with disposal. The recycle of components or entire accelerators following dismantlement is a definite possibility and has occurred in the past. Accelerator components can be recycled either immediately at accelerator shutdown or following a period of storage, depending on the nature of induced activation. Considerations of cost, radioactive waste, and radiological health are presented for four prototypic accelerators. Prototypes considered range from small accelerators having minimal amounts of radioactive mmaterial to a very large accelerator having massive components containing nonnegligible amounts of induced activation. Archival information on past decommissionings is presented, and recommendations concerning regulations and accelerator design that will aid in the decommissioning of an accelerator are given.

  12. Do you want to build such a machine? : Designing a high energy proton accelerator for Argonne National Laboratory.

    Energy Technology Data Exchange (ETDEWEB)

    Paris, E.

    2004-04-05

    Argonne National Laboratory's efforts toward researching, proposing and then building a high-energy proton accelerator have been discussed in a handful of studies. In the main, these have concentrated on the intense maneuvering amongst politicians, universities, government agencies, outside corporations, and laboratory officials to obtain (or block) approval and/or funds or to establish who would have control over budgets and research programs. These ''top-down'' studies are very important but they can also serve to divorce such proceedings from the individuals actually involved in the ground-level research which physically served to create theories, designs, machines, and experiments. This can lead to a skewed picture, on the one hand, of a lack of effect that so-called scientific and technological factors exert and, on the other hand, of the apparent separation of the so-called social or political from the concrete practice of doing physics. An exception to this approach can be found in the proceedings of a conference on ''History of the ZGS'' held at Argonne at the time of the Zero Gradient Synchrotron's decommissioning in 1979. These accounts insert the individuals quite literally as they are, for the most part, personal reminiscences of those who took part in these efforts on the ground level. As such, they are invaluable raw material for historical inquiry but generally lack the rigor and perspective expected in a finished historical work. The session on ''Constructing Cold War Physics'' at the 2002 annual History of Science Society Meeting served to highlight new approaches circulating towards history of science and technology in the post-WWII period, especially in the 1950s. There is new attention towards the effects of training large numbers of scientists and engineers as well as the caution not to equate ''national security'' with military preparedness, but rather

  13. Modeling of titration experiments by a reactive transport model

    Institute of Scientific and Technical Information of China (English)

    Ma Hongyun; Samper Javier; Xin Xin

    2011-01-01

    Acid mine drainage (AMD) is commonly treated by neutralization with alkaline substances. This treatment is supported by titration experiments that illustrate the buffering mechanisms and estimate the base neutralization capacity (BNC) of the AMD. Detailed explanation of titration curves requires modeling with a hydro-chemical model. In this study the titration curves of water samples from the drainage of the As Pontes mine and the corresponding dumps have been investigated and six buffers are selected by analyzing those curves. Titration curves have been simulated by a reactive transport model to discover the detailed buffering mechanisms. These simulations show seven regions involving different buffering mechanism. The BNC is primarily from buffers of dissolved Fe, Al and hydrogen sulfate. The BNC can be approximated by: BNC = 3(CFe + CAl) + 0.05Csulfate, where the units are mol/L. The BNC of the sample from the mine is 9.25 × 10-3 mol/L and that of the dumps sample is 1.28 × 10-2 mol/L.

  14. Isothermal Titration Calorimetry Can Provide Critical Thinking Opportunities

    Science.gov (United States)

    Moore, Dale E.; Goode, David R.; Seney, Caryn S.; Boatwright, Jennifer M.

    2016-01-01

    College chemistry faculties might not have considered including isothermal titration calorimetry (ITC) in their majors' curriculum because experimental data from this instrumental method are often analyzed via automation (software). However, the software-based data analysis can be replaced with a spreadsheet-based analysis that is readily…

  15. A dipstick sensor for coulometric acid-base titrations

    NARCIS (Netherlands)

    Olthuis, W.; Schoot, van der B.H.; Chavez, F.; Bergveld, P.

    1989-01-01

    By performing an acid-base titration by coulometric generation of OH− or H+ ions at an inert electrode in close proximity to the pH-sensitive gate of an ISFET, it is possible to determine the acid or base concentration of a solution using the ISFET as an indicator device for the equivalence point in

  16. Future accelerators (?)

    Energy Technology Data Exchange (ETDEWEB)

    John Womersley

    2003-08-21

    I describe the future accelerator facilities that are currently foreseen for electroweak scale physics, neutrino physics, and nuclear structure. I will explore the physics justification for these machines, and suggest how the case for future accelerators can be made.

  17. Measurements and modeling of gamma absorbed doses due to releases from a linear proton accelerator: experimental design and preliminary results

    International Nuclear Information System (INIS)

    External radiation levels due to positron annihilation radiation from 11C, 13N, and 15O released by the 800 MeV linear proton accelerator at the Los Alamos Meson Physics Facility (LAMPF) have been monitored at a fence-line location both by thermoluminescent dosimeters (TLDs) and high pressure ionization chambers (HPICs). The accelerator is located in irregular terrain consisting of mesas and canyons. Fifteen-minute, accumulated external radiation levels were recorded with the HPICs. Instruments on a nerby meteorological tower concurrently measured wind speed and direction at three levels, temperature at two levels, solar radiation, and rainfall. Real-time radionuclide release rates and stack velocities were measured at the release point with in-stack monitors. This paper presents analyses of short-term radiation levels using HPICs and long-term levels using TLDs. Work being done to develop a computer model to predict external radiation levels based on meteorological data is also discussed

  18. Evolution of structure and properties of VVER-1000 RPV steels under accelerated irradiation up to beyond design fluences

    Science.gov (United States)

    Gurovich, B.; Kuleshova, E.; Shtrombakh, Ya.; Fedotova, S.; Maltsev, D.; Frolov, A.; Zabusov, O.; Erak, D.; Zhurko, D.

    2015-01-01

    In this paper comprehensive studies of structure and properties of VVER-1000 RPV steels after the accelerated irradiation to fluences corresponding to extended lifetime up to 60 years or more as well as comparative studies of materials irradiated with different fluxes were carried out. The significant flux effect is confirmed for the weld metal (nickel concentration ⩾1.35%) which is mainly due to development of reversible temper brittleness. The rate of radiation embrittlement of VVER-1000 RPV steels under operation up to 60 years and more (based on the results of accelerated irradiation considering flux effect for weld metal) is expected not to differ significantly from the observed rate under irradiation within surveillance specimens.

  19. Accelerator Toolbox for MATLAB

    International Nuclear Information System (INIS)

    This paper introduces Accelerator Toolbox (AT)--a collection of tools to model particle accelerators and beam transport lines in the MATLAB environment. At SSRL, it has become the modeling code of choice for the ongoing design and future operation of the SPEAR 3 synchrotron light source. AT was designed to take advantage of power and simplicity of MATLAB--commercially developed environment for technical computing and visualization. Many examples in this paper illustrate the advantages of the AT approach and contrast it with existing accelerator code frameworks

  20. W.K.H. Panofsky Prize in Experimental Particle Physics: The design, construction and performance of the B Factory accelerator facilities, PEP-II and KEKB

    Science.gov (United States)

    Dorfan, Jonathan

    2016-03-01

    The discovery and elucidation of CP violation in the B-meson system presented daunting challenges for the accelerator and detector facilities. This talk discusses how these challenges were met and overcome in the electron-positron colliding-beam accelerator facilities PEP-II (at SLAC) and KEKB (at KEK). The key challenge was to produce unprecedentedly large numbers of B-mesons in a geometry that provided high-statistics, low-background samples of decays to CP eigenstates. This was realized with asymmetric collisions at the Γ(4S) at peak luminosities in excess of 3 ×1033 /sq. cm/sec. Specialized optics were developed to generate efficient, low background, multi-bunch collisions in an energy-asymmetric collision geometry. Novel technologies for the RF, vacuum and feedback systems permitted the storage of multi-amp, multi-bunch beams of electrons and positrons, thereby generating high peak luminosities. Accelerator uptimes greater than 95 percent, combined with high-intensity injection systems, ensured large integrated luminosity. Both facilities rapidly attained their design specifications and ultimately far exceeded the projected performance expectations for both peak and integrated luminosity.

  1. A design for a high intensity slow positron facility using forward scattered radiation from an electron linear accelerator

    International Nuclear Information System (INIS)

    A tungsten moderator will be placed behind the target of the Oak Ridge Electron Linear Accelerator (ORELA) to convert gamma radiation to slow positrons. These will be extracted and led through evacuated solenoids to an experiment room. A Penning trap will be used to extend the slow positron pulses to achieve duty factors of 10% or greater. The facility will be used for atomic and molecular physics studies, positron microscopy, and materials research. Operations will be inexpensive and will not interfere with the normal function of ORELA, the measurement of neutron cross sections by flight-time spectrometry. (orig.)

  2. Accelerator programme at CAT

    International Nuclear Information System (INIS)

    The Accelerator Programme at the Centre for Advanced Technology (CAT), Indore, has very broad based concept under which all types of accelerators are to be taken up for design and fabrication. This centre will be housing a wide variety of accelerators to serve as a common facility for the universities, national laboratories in addition to laboratories under the Department of Atomic Energy. In the first phase of the programme, a series of electron accelerators are designed and fabricated. They are synchrotron radiation sources of 450 MeV (INDUS-I) and of 2 GeV (INDUS-II), microtron upto energy of 20 MeV, linear accelerator upto 20 MeV, and DC Accelerator for industrial irradiation upto 750 KeV and 20 KW. A proton accelerator of 300 MeV with 20 MeV linac injector is also designed. CAT is also developing a strong base for support technologies like ultra high vacuum, radio frequency and microwaves, DC pulsed and superconducting magnets, power supplies and controls etc. These technologies are very useful for other industrial applications also. To develop user groups to utilise INDUS-II synchrotron radiation source, a batch production of rotating Anode X-ray generators with power supplies has been initiated. So also, the sputter ion pumps, electron guns, turbo molecular pumps are brought into batch production. (author)

  3. Neutron cross-sections above 20 MeV for design and modeling of accelerator driven systems

    Science.gov (United States)

    Blomgren, J.

    2007-02-01

    One of the outstanding new developments in the field of partitioning and transmutation (P{&}T) concerns accelerator-driven systems (ADS) which consist of a combination of a high-power, high-energy accelerator, a spallation target for neutron production and a sub-critical reactor core. The development of the commercial critical reactors of today motivated a large effort on nuclear data up to about 20 MeV, and presently several million data points can be found in various data libraries. At higher energies, data are scarce or even non-existent. With the development of nuclear techniques based on neutrons at higher energies, nowadays there is a need also for higher-energy nuclear data. To provide alternative to this lack of data, a wide program on neutron-induced data related to ADS for P{&}T is running at the 20-180 MeV neutron beam facility at `The Svedberg Laboratory' (TSL), Uppsala. The programme encompasses studies of elastic scattering, inelastic neutron production, i.e., (n, xn') reactions, light-ion production, fission and production of heavy residues. Recent results are presented and future program of development is outlined.

  4. Neutron cross-sections above 20 MeV for design and modeling of accelerator driven systems

    Indian Academy of Sciences (India)

    J Blomgren

    2007-02-01

    One of the outstanding new developments in the field of partitioning and transmutation (P&T) concerns accelerator-driven systems (ADS) which consist of a combination of a high-power, high-energy accelerator, a spallation target for neutron production and a sub-critical reactor core. The development of the commercial critical reactors of today motivated a large effort on nuclear data up to about 20 MeV, and presently several million data points can be found in various data libraries. At higher energies, data are scarce or even non-existent. With the development of nuclear techniques based on neutrons at higher energies, nowadays there is a need also for higher-energy nuclear data. To provide alternative to this lack of data, a wide program on neutron-induced data related to ADS for P&T is running at the 20–180 MeV neutron beam facility at `The Svedberg Laboratory' (TSL), Uppsala. The programme encompasses studies of elastic scattering, inelastic neutron production, i.e., (, ′) reactions, light-ion production, fission and production of heavy residues. Recent results are presented and future program of development is outlined.

  5. Accelerating Value Creation with Accelerators

    DEFF Research Database (Denmark)

    Jonsson, Eythor Ivar

    2015-01-01

    accelerator programs. Microsoft runs accelerators in seven different countries. Accelerators have grown out of the infancy stage and are now an accepted approach to develop new ventures based on cutting-edge technology like the internet of things, mobile technology, big data and virtual reality. It is also...... with the traditional audit and legal universes and industries are examples of emerging potentials both from a research and business point of view to exploit and explore further. The accelerator approach may therefore be an Idea Watch to consider, no matter which industry you are in, because in essence accelerators...

  6. Applications of isothermal titration calorimetry in protein science

    Institute of Scientific and Technical Information of China (English)

    Yi Liang

    2008-01-01

    During the past decade,isothermal titration calorimetry (ITC)has developed from a specialist method for understanding molecular interactions and other biological processes within cells to a more robust,widely used method.Nowadays,ITC is used to investigate all types of protein interactions,including protein-protein interactions,protein-DNA/RNA interactions,protein-small molecule interactions and enzyme kinetics;it provides a direct route to the complete thermodynamic characterization of protein interactions.This review concentrates on the new applications of ITC in protein folding and misfolding,its traditional application in protein interactions,and an overview of what can be achieved in the field of protein science using this method and what developments are likely to occur in the near future.Also,this review discusses some new developments of ITC method in protein science,such as the reverse titration of ITC and the displacement method of ITC.

  7. High-throughput titration of luciferase-expressing recombinant viruses.

    Science.gov (United States)

    Garcia, Vanessa; Krishnan, Ramya; Davis, Colin; Batenchuk, Cory; Le Boeuf, Fabrice; Abdelbary, Hesham; Diallo, Jean-Simon

    2014-01-01

    Standard plaque assays to determine infectious viral titers can be time consuming, are not amenable to a high volume of samples, and cannot be done with viruses that do not form plaques. As an alternative to plaque assays, we have developed a high-throughput titration method that allows for the simultaneous titration of a high volume of samples in a single day. This approach involves infection of the samples with a Firefly luciferase tagged virus, transfer of the infected samples onto an appropriate permissive cell line, subsequent addition of luciferin, reading of plates in order to obtain luminescence readings, and finally the conversion from luminescence to viral titers. The assessment of cytotoxicity using a metabolic viability dye can be easily incorporated in the workflow in parallel and provide valuable information in the context of a drug screen. This technique provides a reliable, high-throughput method to determine viral titers as an alternative to a standard plaque assay.

  8. Titrating Polyelectrolytes - Variational Calculations and Monte Carlo Simulations

    CERN Document Server

    Jönsson, B; Peterson, C; Sommelius, O; Söderberg, B

    1995-01-01

    Variational methods are used to calculate structural and thermodynamical properties of a titrating polyelectrolyte in a discrete representation. The Coulomb interactions are emulated by harmonic repulsive forces, the force constants being used as variational parameters to minimize the free energy. For the titrating charges, a mean field approach is used. The accuracy is tested against Monte Carlo data for up to 1000 monomers. For an unscreened chain, excellent agreement is obtained for the end-to-end distance and the apparent dissociation constant. With screening, the thermodynamical properties are invariably well described, although the structural agreement deteriorates. A very simple rigid-rod approximation is also considered, giving surprisingly good results for certain properties.

  9. Laser accelerator

    OpenAIRE

    Vigil, Ricardo

    2014-01-01

    Approved for public release; distribution is unlimited In 1979,W. B. Colson and S. K. Ride proposed a new kind of electron accelerator using a uniform magnetic field in combination with a circularly-polarized laser field. A key concept is to couple the oscillating electric field to the electron’s motion so that acceleration is sustained. This dissertation investigates the performance of the proposed laser accelerator using modern high powered lasers and mag-netic fields that are significan...

  10. Monitoring assembly of ribonucleoprotein complexes by isothermal titration calorimetry

    OpenAIRE

    Recht, Michael I.; Ryder, Sean P.; Williamson, James R.

    2008-01-01

    Isothermal titration calorimetry (ITC) is a useful technique to study RNA-protein interactions, as it provides the only method by which the thermodynamic parameters of free energy, enthalpy, and entropy can be directly determined. This chapter presents a general procedure for studying RNA-protein interactions using ITC, and gives specific examples for monitoring the binding of Caenorhabditis elegans GLD-1 STAR domain to TGE RNA and the binding of Aquifex aeolicus S6:S18 ribosomal protein hete...

  11. Characterization of Native and Modified Starches by Potentiometric Titration

    OpenAIRE

    Diana Soto; Jose Urdaneta; Kelly Pernia

    2014-01-01

    The use of potentiometric titration for the analysis and characterization of native and modified starches is highlighted. The polyelectrolytic behavior of oxidized starches (thermal and thermal-chemical oxidation), a graft copolymer of itaconic acid (IA) onto starch, and starch esters (mono- and diester itaconate) was compared with the behavior of native starch, the homopolymer, and the acid employed as a graft monomer and substituent. Starch esters showed higher percentages of acidity, follo...

  12. Titration of Human Coronaviruses Using an Immunoperoxidase Assay

    OpenAIRE

    Lambert, Francine; Jacomy, Helene; Marceau, Gabriel; J. Talbot, Pierre

    2008-01-01

    Calculation of infectious viral titers represents a basic and essential experimental approach for virologists. Classical plaque assays cannot be used for viruses that do not cause significant cytopathic effects, which is the case for strains 229E and OC43 of human coronavirus (HCoV). An alternative indirect immunoperoxidase assay (IPA) is herein described for the detection and titration of these viruses. Susceptible cells are inoculated with serial logarithmic dilutions of samples in a 96-wel...

  13. Predicting proton titration in cationic micelle and bilayer environments

    OpenAIRE

    Brian H. Morrow; Eike, David M.; Murch, Bruce P.; Koenig, Peter H.; Shen, Jana K.

    2014-01-01

    Knowledge of the protonation behavior of pH-sensitive molecules in micelles and bilayers has significant implications in consumer product development and biomedical applications. However, the calculation of pKa’s in such environments proves challenging using traditional structure-based calculations. Here we apply all-atom constant pH molecular dynamics with explicit ions and titratable water to calculate the pKa of a fatty acid molecule in a micelle of dodecyl trimethylammonium chloride and l...

  14. Improvement in the Design of Metal-Ceramic High Voltage Feedthroughs for use in High Energy Particle Accelerators

    CERN Document Server

    Weterings, W

    1999-01-01

    Large high-voltage devices operate in particle accelerators to steer charged particles in the desired direction. Solid and hollow rods of sintered alumina are used as insulating supports and high-voltage feedthroughs to power the electrodes of these electrostatic systems. The performance of the systems is often limited by voltage breakdown along the surface of the ceramic insulator (so-called surface flashover) or discharge between feedthrough and vacuum tank, which can lead to significant disruptions in terms of overall machine efficiency. Available results on the influence of the mechanical preparation, thermal history and particular cleaning techniques on commercially obtainable alumina samples have been studied in order to investigate possibilities for better preparation methodology of the insulating supports. Also the influence of the relative position of the feedthrough inside the vacuum tank on the high-voltage breakdown behaviour has been studied. This paper describes the theoretical and practical bac...

  15. Titrating and evaluating multi-drug regimens within subjects.

    Science.gov (United States)

    Shih, Margaret; Gennings, Chris; Chinchilli, Vernon M; Carter, Walter H

    2003-07-30

    The dosing of combination therapies is commonly undertaken empirically by practising physicians, and a coherent algorithm to approach the problem of combination dosing is currently lacking. Current methods of evaluating multiple drug combinations in clinical trials fail to provide information regarding the location of more effective doses when the combination is not found to differ from the standard, even though the absence of a difference does not necessarily mean the new combination is ineffective. Moreover, in studies where the new combination is found more effective, often a large proportion of the study participants obtain no benefit from the trial. Even with early stopping rules, the time these subjects spend on inferior treatments can have lasting detrimental effects, leading to problems with patient enrolment and adherence to study protocol. This paper describes an evolutionary operation (EVOP) direct-search procedure to titrate combination doses within individual patients. The Nelder-Mead simplex direct-search algorithm is used to titrate combinations of drugs within individual subjects. Desirability functions are utilized to define the main response of interest and additional responses or constraints. Statistical methodology for determining whether the titrated treatment combination has resulted in an improvement in subject response and for evaluating for therapeutic synergism is developed. Inferences can then be made about the efficacy of the combination or about the individual drugs that comprise the combination. The advantages of this approach include affording every patient the potential to benefit from the combination under study and permitting the consideration of multiple endpoints simultaneously. PMID:12854092

  16. A titration microcalorimeter and the vesicle of mixed surfactants

    Institute of Scientific and Technical Information of China (English)

    白光月[1; 王玉洁[2; 王金本[3; 杨冠英[4; 韩布兴[5; 闫海科[6

    2000-01-01

    A titration microcalorimeter with the sample cells of 1 mL and 3 mL volume was constructed by combining LKB-2107 ampule microcalorimeter with an improved Thermometric titration microcalorimeter. Its sensitivity and precision were tested with the baseline noise and stability, the measurement of energy equivalent, and the linear relation of electric energy and integral area as the function of voltage (V)-time (f). Its accuracy was demonstrated by measuring the dilution enthalpy of a concentrated sucrose solution and the micelle-forming enthalpy of sodium dodecyl sulfate (SDS) in aqueous solution respectively. At the same time, the enthalpy of interaction between SDS and didodecyldimethylammonium bromide (DDAB) was measured by using the titration microcalorimeter, and the phase behavior of SDS-DDAB aqueous mixture was discussed. The microcalorimetric results show that the enthalpy of interaction between SDS and DDAB micelles is -29.53 kJ/mol, the enthalpy of formation of 1:1 SDS-DDAB salt is -125.8 kJ/mol,

  17. A titration microcalorimeter and the vesicle of mixed surfactants

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A titration microcalorimeter with the sample cells of 1 mL and 3 mL volume was constructed by combining LKB-2107 ampule microcalorimeter with an improved Thermometric titration microcalorimeter. Its sensitivity and precision were tested with the baseline noise and stability, the measurement of energy equivalent, and the linear relation of electric energy and integral area as the function of voltage (V )-time (t ). Its accuracy was demonstrated by measuring the dilution enthalpy of a concentrated sucrose solution and the micelle-forming enthalpy of sodium dodecyl sulfate (SDS) in aqueous solution respectively. At the same time, the enthalpy of interaction between SDS and didodecyldimethylammonium bromide (DDAB) was measured by using the titration microcalorimeter, and the phase behavior of SDS-DDAB aqueous mixture was discussed. The microcalorimetric results show that the enthalpy of interaction between SDS and DDAB micelles is ?29.53 kJ/mol, the enthalpy of formation of 1:1 SDS-DDAB salt is ?125.8 kJ/mol, the vesicle-forming enthalpy of SDS-DDAB is 41.23 kJ/mol, and the enthalpy of phase transition from vesicles to SDS rich micelle is 32.10 kJ/mol.

  18. TH-C-12A-08: New Compact 10 MV S-Band Linear Accelerator: 3D Finite-Element Design and Monte Carlo Dose Simulations

    International Nuclear Information System (INIS)

    Purpose: To design a new compact S-band linac waveguide capable of producing a 10 MV x-ray beam, while maintaining the length (27.5 cm) of current 6 MV waveguides. This will allow higher x-ray energies to be used in our linac-MRI systems with the same footprint. Methods: Finite element software COMSOL Multiphysics was used to design an accelerator cavity matching one published in an experiment breakdown study, to ensure that our modeled cavities do not exceed the threshold electric fields published. This cavity was used as the basis for designing an accelerator waveguide, where each cavity of the full waveguide was tuned to resonate at 2.997 GHz by adjusting the cavity diameter. The RF field solution within the waveguide was calculated, and together with an electron-gun phase space generated using Opera3D/SCALA, were input into electron tracking software PARMELA to compute the electron phase space striking the x-ray target. This target phase space was then used in BEAM Monte Carlo simulations to generate percent depth doses curves for this new linac, which were then used to re-optimize the waveguide geometry. Results: The shunt impedance, Q-factor, and peak-to-mean electric field ratio were matched to those published for the breakdown study to within 0.1% error. After tuning the full waveguide, the peak surface fields are calculated to be 207 MV/m, 13% below the breakdown threshold, and a d-max depth of 2.42 cm, a D10/20 value of 1.59, compared to 2.45 cm and 1.59, respectively, for the simulated Varian 10 MV linac and brehmsstrahlung production efficiency 20% lower than a simulated Varian 10 MV linac. Conclusion: This work demonstrates the design of a functional 27.5 cm waveguide producing 10 MV photons with characteristics similar to a Varian 10 MV linac

  19. Design and simulation of 3½-cell superconducting gun cavity and beam dynamics studies of the SASE-FEL System at the Institute of Accelerator Technologies at Ankara University

    International Nuclear Information System (INIS)

    Design and simulation of a superconducting gun cavity with 3½ cells have been studied in order to give the first push to the electron beam for the linear accelerating system at The Institute of Accelerator Technologies at Ankara University. Electrons are accelerated through the gun cavity with the help of the Radiofrequency power suppliers from cryogenic systems. Accelerating gradient should be as high as possible to accelerate electron beam inside the cavity. In this study, electron beam reaches to 9.17 MeV energy at the end of the gun cavity with the accelerating gradient; Ec=19.21 MV/m. 1.3 GHz gun cavity consists of three TESLA-like shaped cells while the special designed gun-cell includes a cathode plug. Optimized important beam parameters inside the gun cavity, average beam current 3 mA, transverse emittance 2.5 mm mrad, repetition rate 30 MHz and other parameters are obtained for the SASE-FEL System. The Superfish/Poisson program is used to design each cell of the superconducting cavity. Superconducting gun cavity and Radiofrequency properties are studied by utilizing 2D Superfish/Poisson, 3D Computer Simulation Technology Microwave Studio, and 3D Computer Simulation Technology Particle Studio. Superfish/Poisson is also used to optimize the geometry of the cavity cells to get the highest accelerating gradient. The behavior of the particles along the beamline is included in this study. ASTRA Code is used to track the particles

  20. Design and simulation of 3½-cell superconducting gun cavity and beam dynamics studies of the SASE-FEL System at the Institute of Accelerator Technologies at Ankara University

    Science.gov (United States)

    Yildiz, H. Duran; Cakir, R.; Porsuk, D.

    2015-06-01

    Design and simulation of a superconducting gun cavity with 3½ cells have been studied in order to give the first push to the electron beam for the linear accelerating system at The Institute of Accelerator Technologies at Ankara University. Electrons are accelerated through the gun cavity with the help of the Radiofrequency power suppliers from cryogenic systems. Accelerating gradient should be as high as possible to accelerate electron beam inside the cavity. In this study, electron beam reaches to 9.17 MeV energy at the end of the gun cavity with the accelerating gradient; Ec=19.21 MV/m. 1.3 GHz gun cavity consists of three TESLA-like shaped cells while the special designed gun-cell includes a cathode plug. Optimized important beam parameters inside the gun cavity, average beam current 3 mA, transverse emittance 2.5 mm mrad, repetition rate 30 MHz and other parameters are obtained for the SASE-FEL System. The Superfish/Poisson program is used to design each cell of the superconducting cavity. Superconducting gun cavity and Radiofrequency properties are studied by utilizing 2D Superfish/Poisson, 3D Computer Simulation Technology Microwave Studio, and 3D Computer Simulation Technology Particle Studio. Superfish/Poisson is also used to optimize the geometry of the cavity cells to get the highest accelerating gradient. The behavior of the particles along the beamline is included in this study. ASTRA Code is used to track the particles.

  1. Hadron accelerators in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Amaldi, U. [European Organization for Nuclear Research (CERN), Geneva (Switzerland). Accelerator School; Silari, M. [Consiglio Nazionale delle Ricerche, Milan (Italy)

    1996-12-31

    The application of hadron accelerators (protons and light ions) in cancer therapy is discussed. After a brief introduction on the rationale for the use of heavy charged particles in radiation therapy, a discussion is given on accelerator technology and beam delivery systems. Next, existing and planned facilities are briefly reviewed. The Italian Hadron-therapy Project is then described in some detail, with reference ro both the National Centre for Oncological Hadron-therapy and the design of different types of compact proton accelerators aimed at introducing proton therapy in a large umber of hospitals. (author) 28 refs.

  2. Availability, reliability and logistic support studies of the RF power system design options for the IFMIF accelerator

    International Nuclear Information System (INIS)

    Highlights: ► Current RF system design based on tetrodes chains is evaluated. ► Alternative solid state power amplifiers RF system design is analyzed. ► Both designs are compared in terms of availability, logistics and cost. ► It is concluded that solid state option presents relevant improvements. -- Abstract: The current design of the radio frequency (RF) power system for the International Fusion Materials Irradiation Facility (IFMIF) is based upon tetrodes technology. Due to the improvement in the solid state amplifiers technology, the possibility of using this option for IFMIF RF system is becoming a very competitive alternative presenting from the beginning several advantages in terms of availability, reliability and logistics. The current design based on RF tetrodes chains leads no room for substantial improvements in terms of availability being the requirement for the RF system hard to achieve. The principal goals of this paper are to use RAMI (Reliability, Availability, Maintainability and Inspectionability) analysis in the solid state amplifier design, and to compare the availability, reliability and logistic performances for both alternatives

  3. 3-dimensional shielding design for a spallation neutron source facility in the high-intensity proton accelerator project

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, Masaya; Maekawa, Fujio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    Evaluation of shielding performance for a 1 MW spallation neutron source facility in the Materials and Life Science Facility being constructed in the High-Intensity Proton Accelerator Project (J-PARC) is important from a viewpoint of radiation safety and optimization of arrangement of components. This report describes evaluated results for the shielding performance with modeling three-dimensionally whole structural components including gaps between them in detail. A Monte Carlo calculation method with MCNPX2.2.6 code and LA-150 library was adopted. Streaming and void effects, optimization of shield for cost reduction and optimization of arrangement of structures such as shutters were investigated. The streaming effects were investigated quantitatively by changing the detailed structure of components and gap widths built into the calculation model. Horizontal required shield thicknesses were ranged from about 6.5 m to 7.5 m as a function of neutron beam line angles. A shutter mechanism for a horizontal neutron reflectometer that was directed downward was devised, and it was shown that the shielding performance of the shutter was acceptable. An optimal biological shield configuration was finally determined according to the calculated results. (author)

  4. Characterization of Vertical Accelerations Experienced by Older People Attending an Aerobics Class Designed to Produce High Impacts.

    Science.gov (United States)

    Hannam, Kimberly; Deere, Kevin; Worrall, Sue; Hartley, April; Tobias, Jon H

    2016-04-01

    The purpose of this study was to establish the feasibility of using an aerobics class to produce potentially bone protective vertical impacts of ≥ 4g in older adults and to determine whether impacts can be predicted by physical function. Participants recruited from older adult exercise classes completed an SF-12 questionnaire, short physical performance battery, and an aerobics class with seven different components, performed at low and high intensity. Maximum g and jerk values were identified for each activity. Forty-one participants (mean 69 years) were included. Mean maximal values approached or exceeded the 4g threshold for four of the seven exercises. In multivariate analyses, age (-0.53; -0.77, -0.28) (standardized beta coefficient; 95% CI) and 4-m walk time (-0.39; -0.63, -0.16) were inversely related to maximum g. Aerobics classes can be used to produce relatively high vertical accelerations in older individuals, although the outcome is strongly dependent on age and physical function. PMID:26421605

  5. Shielding design of a treatment room for an accelerator-based epithermal neutron irradiation facility for BNCT

    International Nuclear Information System (INIS)

    Protecting the facility personnel and the general public from radiation exposure is a primary safety concern of an accelerator-based epithermal neutron irradiation facility. This work makes an attempt at answering the questions open-quotes How much?close quotes and open-quotes What kind?close quotes of shielding will meet the occupational limits of such a facility. Shielding effectiveness is compared for ordinary and barytes concretes in combination with and without borated polyethylene. A calculational model was developed of a treatment room, patient open-quotes scatterer,close quotes and the epithermal neutron beam. The Monte Carlo code, MCNP, was used to compute the total effective dose equivalent rates at specific points of interest outside of the treatment room. A conservative occupational effective dose rate limit of 0.01 mSv h-1 was the guideline for this study. Conservative Monte Carlo calculations show that constructing the treatment room walls with 1.5 m of ordinary concrete, 1.2 m of barytes concrete, 1.0 m of ordinary concrete preceded by 10 cm of 5% boron-polyethylene, or 0.8 m of barytes concrete preceded by 10 cm of 5% boron-polyethylene will adequately protect facility personnel. 20 refs., 8 figs., 2 tabs

  6. Research and design of scanning power supply for deep tumor therapy facility with heavy ions accelerator in Lanzhou

    International Nuclear Information System (INIS)

    This paper describes the technique targets and operation principle of the scanning power supply for the deep tumor therapy facility with heavy ions in Cooler-Storage-Ring of the Heavy Ion Research Facility in Lanzhou (HIRFL-CSR). To ensure the specified accuracy of the current, the hysteresis loop control strategy was adopted, and tracking error was constrained in the specified tolerance. One prototype was designed and installed. And the simulation results and test results were listed in the paper. The results show that all the targets can meet the design requirements, and that the circuit configuration and hysteresis loop control strategy selected are practicable. (authors)

  7. Design, construction and installation of the electromechanical components of the current control of filament of the Pelletron Electron Accelerator; Diseno, construccion e instalacion de las componentes electromecanicas del control de corriente de filamento del acelerador de electrones Pelletron

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar J, R.A.; Valdovinos A, M.; Lopez V, H. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1985-01-15

    For the operation of the Pelletron electron accelerator is required to have control of the filament current. For it was designed, built and installed an electromechanical system located in the Acceleration Unit inside the Accelerator tank and operated from the Control console. All the components located inside the tank operated under the following conditions: Pressure: until 7.03 Kg/cm{sup 2}; High voltage: 10{sup 6} V (only the insulating arrow); Atmosphere: mixture of N{sub 2} and CO{sub 2} or SF{sub 6}. (Author)

  8. The miniature accelerator

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    The image that most people have of CERN is of its enormous accelerators and their capacity to accelerate particles to extremely high energies. But thanks to some cutting-edge studies on beam dynamics and radiofrequency technology, along with innovative construction techniques, teams at CERN have now created the first module of a brand-new accelerator, which will be just 2 metres long. The potential uses of this miniature accelerator will include deployment in hospitals for the production of medical isotopes and the treatment of cancer. It’s a real David-and-Goliath story.   Serge Mathot, in charge of the construction of the "mini-RFQ", pictured with the first of the four modules that will make up the miniature accelerator. The miniature accelerator consists of a radiofrequency quadrupole (RFQ), a component found at the start of all proton accelerator chains around the world, from the smallest to the largest. The LHC is designed to produce very high-intensity beams ...

  9. Large electrostatic accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Jones, C.M.

    1984-01-01

    The increasing importance of energetic heavy ion beams in the study of atomic physics, nuclear physics, and materials science has partially or wholly motivated the construction of a new generation of large electrostatic accelerators designed to operate at terminal potentials of 20 MV or above. In this paper, the author briefly discusses the status of these new accelerators and also discusses several recent technological advances which may be expected to further improve their performance. The paper is divided into four parts: (1) a discussion of the motivation for the construction of large electrostatic accelerators, (2) a description and discussion of several large electrostatic accelerators which have been recently completed or are under construction, (3) a description of several recent innovations which may be expected to improve the performance of large electrostatic accelerators in the future, and (4) a description of an innovative new large electrostatic accelerator whose construction is scheduled to begin next year. Due to time and space constraints, discussion is restricted to consideration of only tandem accelerators.

  10. Design of a flowing heavy metal target with a free surface for an accelerator driven neutron source

    International Nuclear Information System (INIS)

    In the paper the design of the flowing heavy metal target with free surface under proton beam irradiation within 0.8-1.6 GeV energy and the 10-320 mA current range is presented and analyzed. Following data submitted below: - the results of numerical modeling of the heat deposition in the Pb-Bi eutectic flow due to the penetrating through the proton beam; - the numerical investigation of swirling flow with a free surface; - the calculation of the temperature distributions occurring in the flowing heavy metal target because of the proton beam energy deposition; - the main construction parameters of the flowing heavy metal targets for the proton beams within 0.8-1.6 GeV energy and the 10-320 mA current range; - the design and numerical investigations of the supersonic wind shutter which is needed to isolate the vacuum part of the proton line. 3 refs., 10 figs

  11. A titration model for evaluating calcium hydroxide removal techniques

    Directory of Open Access Journals (Sweden)

    Mark PHILLIPS

    2015-02-01

    Full Text Available Objective Calcium hydroxide (Ca(OH2 has been used in endodontics as an intracanal medicament due to its antimicrobial effects and its ability to inactivate bacterial endotoxin. The inability to totally remove this intracanal medicament from the root canal system, however, may interfere with the setting of eugenol-based sealers or inhibit bonding of resin to dentin, thus presenting clinical challenges with endodontic treatment. This study used a chemical titration method to measure residual Ca(OH2 left after different endodontic irrigation methods. Material and Methods Eighty-six human canine roots were prepared for obturation. Thirty teeth were filled with known but different amounts of Ca(OH2 for 7 days, which were dissolved out and titrated to quantitate the residual Ca(OH2 recovered from each root to produce a standard curve. Forty-eight of the remaining teeth were filled with equal amounts of Ca(OH2 followed by gross Ca(OH2 removal using hand files and randomized treatment of either: 1 Syringe irrigation; 2 Syringe irrigation with use of an apical file; 3 Syringe irrigation with added 30 s of passive ultrasonic irrigation (PUI, or 4 Syringe irrigation with apical file and PUI (n=12/group. Residual Ca(OH2 was dissolved with glycerin and titrated to measure residual Ca(OH2 left in the root. Results No method completely removed all residual Ca(OH2. The addition of 30 s PUI with or without apical file use removed Ca(OH2 significantly better than irrigation alone. Conclusions This technique allowed quantification of residual Ca(OH2. The use of PUI (with or without apical file resulted in significantly lower Ca(OH2 residue compared to irrigation alone.

  12. Titratable acidity of beverages influences salivary pH recovery

    Directory of Open Access Journals (Sweden)

    Livia Maria Andaló TENUTA

    2015-01-01

    Full Text Available A low pH and a high titratable acidity of juices and cola-based beverages are relevant factors that contribute to dental erosion, but the relative importance of these properties to maintain salivary pH at demineralizing levels for long periods of time after drinking is unknown. In this crossover study conducted in vivo, orange juice, a cola-based soft drink, and a 10% sucrose solution (negative control were tested. These drinks differ in terms of their pH (3.5 ± 0.04, 2.5 ± 0.05, and 5.9 ± 0.1, respectively and titratable acidity (3.17 ± 0.06, 0.57 ± 0.04 and < 0.005 mmols OH- to reach pH 5.5, respectively. Eight volunteers with a normal salivary flow rate and buffering capacity kept 15 mL of each beverage in their mouth for 10 s, expectorated it, and their saliva was collected after 15, 30, 45, 60, 90, and 120 s. The salivary pH, determined using a mini pH electrode, returned to the baseline value at 30 s after expectoration of the cola-based soft drink, but only at 90 s after expectoration of the orange juice. The salivary pH increased to greater than 5.5 at 15 s after expectoration of the cola drink and at 30 s after expectoration of the orange juice. These findings suggest that the titratable acidity of a beverage influences salivary pH values after drinking acidic beverages more than the beverage pH.

  13. Design, Fabrication and High Power RF Test of a C-band Accelerating Structure for Feasibility Study of the SPARC photo-injector energy upgrade

    CERN Document Server

    Alesini, D.; Di Pirro, G.; Di Raddo, R.; Ferrario, M.; Gallo, A.; Lollo, V.; Marcellini, F.; Higo, T.; Kakihara, K.; Matsumoto, S.; Campogiani, G.; Mostacci, A.; Palumbo, L.; Persichelli, S.; Spizzo, V.; Verdú-Andrés, S.

    2011-01-01

    The energy upgrade of the SPARC photo-injector from 160 to more than 260 MeV will be done by replacing a low gradient 3m S-Band structure with two 1.4m high gradient C-band structures. The structures are travelling wave, constant impedance sections, have symmetric waveguide input couplers and have been optimized to work with a SLED RF input pulse. A prototype with a reduced number of cells has been fabricated and tested at high power in KEK (Japan) giving very good performances in terms of breakdown rates (10^6 bpp/m) at high accelerating gradient (>50 MV/m). The paper illustrates the design criteria of the structures, the fabrication procedure and the high power RF test results.

  14. Design of a control system for a macro-micro dual-drive high acceleration high precision positioning stage for IC packaging

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    A macro-micro dual-drive positioning system showing good potential for high acceleration and high precision positioning required in IC packaging applications is devised in this paper. The dual-drive positioning stage uses a VCM (voice coil motor) driven macro positioning stage and a PZT piezo-electric driven micro positioning stage. The coupling characteristics of the system are analyzed to produce a control structure with a micro positioning stage that can dynamically compensate for the positioning error produced by the macro positioning stage. Models of the two positioning stages are described. The models cover both the mechanism and the actuator. For the macro positioning stage, friction characteristics are taken into account, and a controller with an LQG (linear-quadratic-Gaussian) control algorithm combining a feed-forward compensation algorithm is derived. A PID controller is used to control the micro positioning stage. Detailed designs are derived for the proposed approach, and the performance is validated by simulation.

  15. Accelerator Technology Division annual report, FY 1989

    Energy Technology Data Exchange (ETDEWEB)

    1990-06-01

    This paper discusses: accelerator physics and special projects; experiments and injectors; magnetic optics and beam diagnostics; accelerator design and engineering; radio-frequency technology; accelerator theory and simulation; free-electron laser technology; accelerator controls and automation; and high power microwave sources and effects.

  16. Accelerator Technology Division annual report, FY 1989

    International Nuclear Information System (INIS)

    This paper discusses: accelerator physics and special projects; experiments and injectors; magnetic optics and beam diagnostics; accelerator design and engineering; radio-frequency technology; accelerator theory and simulation; free-electron laser technology; accelerator controls and automation; and high power microwave sources and effects

  17. Characterization of Native and Modified Starches by Potentiometric Titration

    Directory of Open Access Journals (Sweden)

    Diana Soto

    2014-01-01

    Full Text Available The use of potentiometric titration for the analysis and characterization of native and modified starches is highlighted. The polyelectrolytic behavior of oxidized starches (thermal and thermal-chemical oxidation, a graft copolymer of itaconic acid (IA onto starch, and starch esters (mono- and diester itaconate was compared with the behavior of native starch, the homopolymer, and the acid employed as a graft monomer and substituent. Starch esters showed higher percentages of acidity, followed by graft copolymer of itaconic acid and finally oxidized starches. Analytical techniques and synthesis of modified starches were also described.

  18. Semi-automated potentiometric titration method for uranium characterization.

    Science.gov (United States)

    Cristiano, B F G; Delgado, J U; da Silva, J W S; de Barros, P D; de Araújo, R M S; Lopes, R T

    2012-07-01

    The manual version of the potentiometric titration method has been used for certification and characterization of uranium compounds. In order to reduce the analysis time and the influence of the analyst, a semi-automatic version of the method was developed in the Brazilian Nuclear Energy Commission. The method was applied with traceability assured by using a potassium dichromate primary standard. The combined standard uncertainty in determining the total concentration of uranium was around 0.01%, which is suitable for uranium characterization. PMID:22154105

  19. Isothermal Titration Calorimetry: Assisted Crystallization of RNA-Ligand Complexes.

    Science.gov (United States)

    Da Veiga, Cyrielle; Mezher, Joelle; Dumas, Philippe; Ennifar, Eric

    2016-01-01

    The success rate of nucleic acids/ligands co-crystallization can be significantly improved by performing preliminary biophysical analyses. Among suitable biophysical approaches, isothermal titration calorimetry (ITC) is certainly a method of choice. ITC can be used in a wide range of experimental conditions to monitor in real time the formation of the RNA- or DNA-ligand complex, with the advantage of providing in addition the complete binding profile of the interaction. Following the ITC experiment, the complex is ready to be concentrated for crystallization trials. This chapter describes a detailed experimental protocol for using ITC as a tool for monitoring RNA/small molecule binding, followed by co-crystallization.

  20. Sustainable Cost Transformation in Governments Using Accelerated Design of Shared Services, Social CRM and Information Strategy Development

    Directory of Open Access Journals (Sweden)

    Prayas Kad

    2012-03-01

    Full Text Available In advance of the current economic downturn, governments around the world had embarked uponvery well intentioned efficiency remedial measures by observing its customers’ needs and expectations,implementing the shared design services catering to its various common functions across the departments, leveraging benefits with state-of-art introduction of Information technology and Social CRM. Bringing this approach together helps cost reduction programs introduced by the government produce better outcome and deliver efficiencies and effectiveness in various government functions along with endorsing sustainability in its different endeavors. Strong alignment among the various government departments and buy-in to the shared-services philosophy has been realized as the major contributing factor enabling the effective functioning and hence tools the SCRM and I.T. Strategy have been bundled together forming a collaborative approach.

  1. Advances in conformal radiotherapy using Monte Carlo Code to design new IMRT and IORT accelerators and interpret CT numbers

    CERN Document Server

    Wysocka-Rabin, A

    2013-01-01

    The introductory chapter of this monograph, which follows this Preface, provides an overview of radiotherapy and treatment planning. The main chapters that follow describe in detail three significant aspects of radiotherapy on which the author has focused her research efforts. Chapter 2 presents studies the author worked on at the German National Cancer Institute (DKFZ) in Heidelberg. These studies applied the Monte Carlo technique to investigate the feasibility of performing Intensity Modulated Radiotherapy (IMRT) by scanning with a narrow photon beam. This approach represents an alternative to techniques that generate beam modulation by absorption, such as MLC, individually-manufactured compensators, and special tomotherapy modulators. The technical realization of this concept required investigation of the influence of various design parameters on the final small photon beam. The photon beam to be scanned should have a diameter of approximately 5 mm at Source Surface Distance (SSD) distance, and the penumbr...

  2. Characterization of protein-protein interactions by isothermal titration calorimetry.

    Science.gov (United States)

    Velazquez-Campoy, Adrian; Leavitt, Stephanie A; Freire, Ernesto

    2015-01-01

    The analysis of protein-protein interactions has attracted the attention of many researchers from both a fundamental point of view and a practical point of view. From a fundamental point of view, the development of an understanding of the signaling events triggered by the interaction of two or more proteins provides key information to elucidate the functioning of many cell processes. From a practical point of view, understanding protein-protein interactions at a quantitative level provides the foundation for the development of antagonists or agonists of those interactions. Isothermal Titration Calorimetry (ITC) is the only technique with the capability of measuring not only binding affinity but the enthalpic and entropic components that define affinity. Over the years, isothermal titration calorimeters have evolved in sensitivity and accuracy. Today, TA Instruments and MicroCal market instruments with the performance required to evaluate protein-protein interactions. In this methods paper, we describe general procedures to analyze heterodimeric (porcine pancreatic trypsin binding to soybean trypsin inhibitor) and homodimeric (bovine pancreatic α-chymotrypsin) protein associations by ITC.

  3. Measuring Multivalent Binding Interactions by Isothermal Titration Calorimetry.

    Science.gov (United States)

    Dam, Tarun K; Talaga, Melanie L; Fan, Ni; Brewer, Curtis F

    2016-01-01

    Multivalent glycoconjugate-protein interactions are central to many important biological processes. Isothermal titration calorimetry (ITC) can potentially reveal the molecular and thermodynamic basis of such interactions. However, calorimetric investigation of multivalency is challenging. Binding of multivalent glycoconjugates to proteins (lectins) often leads to a stoichiometry-dependent precipitation process due to noncovalent cross-linking between the reactants. Precipitation during ITC titration severely affects the quality of the baseline as well as the signals. Hence, the resulting thermodynamic data are not dependable. We have made some modifications to address this problem and successfully studied multivalent glycoconjugate binding to lectins. We have also modified the Hill plot equation to analyze high quality ITC raw data obtained from multivalent binding. As described in this chapter, ITC-driven thermodynamic parameters and Hill plot analysis of ITC raw data can provide valuable information about the molecular mechanism of multivalent lectin-glycoconjugate interactions. The methods described herein revealed (i) the importance of functional valence of multivalent glycoconjugates, (ii) that favorable entropic effects contribute to the enhanced affinities associated with multivalent binding, (iii) that with the progression of lectin binding, the microscopic affinities of the glycan epitopes of a multivalent glycoconjugate decrease (negative cooperativity), (iv) that lectin binding to multivalent glycoconjugates, especially to mucins, involves internal diffusion jumps, (bind and jump) and (v) that scaffolds of glycoconjugates influence their entropy of binding.

  4. Semi-automated potentiometric titration method for uranium characterization

    Energy Technology Data Exchange (ETDEWEB)

    Cristiano, B.F.G., E-mail: barbara@ird.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Instituto de Radioprotecao e Dosimetria (IRD), Avenida Salvador Allende s/n Recreio dos Bandeirantes, PO Box 37750, Rio de Janeiro, 22780-160 RJ (Brazil); Delgado, J.U.; Silva, J.W.S. da; Barros, P.D. de; Araujo, R.M.S. de [Comissao Nacional de Energia Nuclear (CNEN), Instituto de Radioprotecao e Dosimetria (IRD), Avenida Salvador Allende s/n Recreio dos Bandeirantes, PO Box 37750, Rio de Janeiro, 22780-160 RJ (Brazil); Lopes, R.T. [Programa de Engenharia Nuclear (PEN/COPPE), Universidade Federal do Rio de Janeiro (UFRJ), Ilha do Fundao, PO Box 68509, Rio de Janeiro, 21945-970 RJ (Brazil)

    2012-07-15

    The manual version of the potentiometric titration method has been used for certification and characterization of uranium compounds. In order to reduce the analysis time and the influence of the analyst, a semi-automatic version of the method was developed in the Brazilian Nuclear Energy Commission. The method was applied with traceability assured by using a potassium dichromate primary standard. The combined standard uncertainty in determining the total concentration of uranium was around 0.01%, which is suitable for uranium characterization. - Highlights: Black-Right-Pointing-Pointer We developed a semi-automatic version of potentiometric titration method. Black-Right-Pointing-Pointer The method is used for certification and characterization of uranium compounds. Black-Right-Pointing-Pointer The traceability of the method was assured by a K{sub 2}Cr{sub 2}O{sub 7} primary standard. Black-Right-Pointing-Pointer The results of U{sub 3}O{sub 8} reference material analyzed was consistent with certified value. Black-Right-Pointing-Pointer The uncertainty obtained, near 0.01%, is useful for characterization purposes.

  5. Comparison of VFA titration procedures used for monitoring the biogas process

    DEFF Research Database (Denmark)

    Lützhøft, Hans-Christian Holten; Boe, Kanokwan; Fang, Cheng;

    2014-01-01

    titration procedures. Currently, no standardized procedure is used and it is therefore difficult to compare the performance among plants. The aim of this study was to evaluate four titration procedures (for determination of VFA-levels of digested manure samples) and compare results with gas chromatographic...... (GC) analysis. Two of the procedures are commonly used in biogas plants and two are discussed in literature. The results showed that the optimal titration results were obtained when 40mL of four times diluted digested manure was gently stirred (200rpm). Results from samples with different VFA...... concentrations (1-11g/L) showed linear correlation between titration results and GC measurements. However, determination of VFA by titration generally overestimated the VFA contents compared with GC measurements when samples had low VFA concentrations, i.e. around 1g/L. The accuracy of titration increased when...

  6. The determination of titratable acidity and total tannins in red wine

    OpenAIRE

    Rajković Miloš B.; Sredović Ivana D.

    2009-01-01

    Titration acidity and content of total tannins in mass-market red wines are analyzed in this paper. The content of total acids in wine, expressed through wine acid, was analyzed by potentiometric titration on 7.00 pH value. According to titratable acidity in analyzed wines, all wines (only) with analyzed parameters according to Regulations about wine quality. The analysis of differential potentiometric curves shows that these curves can give the answer to the question if non organic substance...

  7. Thermodynamic signature of secondary nano-emulsion formation by isothermal titration calorimetry.

    Science.gov (United States)

    Fotticchia, Iolanda; Fotticchia, Teresa; Mattia, Carlo Andrea; Netti, Paolo Antonio; Vecchione, Raffaele; Giancola, Concetta

    2014-12-01

    The stabilization of oil in water nano-emulsions by means of a polymer coating is extremely important; it prolongs the shelf life of the product and makes it suitable for a variety of applications ranging from nutraceutics to cosmetics and pharmaceutics. To date, an effective methodology to assess the best formulations in terms of thermodynamic stability has yet to be designed. Here, we perform a complete physicochemical characterization based on isothermal titration calorimetry (ITC) compared to conventional dynamic light scattering (DLS) to identify polymer concentration domains that are thermodynamically stable and to define the degree of stability through thermodynamic functions depending upon any relevant parameter affecting the stability itself, such as type of polymer coating, droplet distance, etc. For instance, the method was proven by measuring the energetics in the case of two different biopolymers, chitosan and poly-L-lysine, and for different concentrations of the emulsion coated with poly-L-lysine.

  8. Pathological tremor prediction using surface electromyogram and acceleration: potential use in ‘ON-OFF’ demand driven deep brain stimulator design

    Science.gov (United States)

    Basu, Ishita; Graupe, Daniel; Tuninetti, Daniela; Shukla, Pitamber; Slavin, Konstantin V.; Verhagen Metman, Leo; Corcos, Daniel M.

    2013-06-01

    Objective. We present a proof of concept for a novel method of predicting the onset of pathological tremor using non-invasively measured surface electromyogram (sEMG) and acceleration from tremor-affected extremities of patients with Parkinson’s disease (PD) and essential tremor (ET). Approach. The tremor prediction algorithm uses a set of spectral (Fourier and wavelet) and nonlinear time series (entropy and recurrence rate) parameters extracted from the non-invasively recorded sEMG and acceleration signals. Main results. The resulting algorithm is shown to successfully predict tremor onset for all 91 trials recorded in 4 PD patients and for all 91 trials recorded in 4 ET patients. The predictor achieves a 100% sensitivity for all trials considered, along with an overall accuracy of 85.7% for all ET trials and 80.2% for all PD trials. By using a Pearson’s chi-square test, the prediction results are shown to significantly differ from a random prediction outcome. Significance. The tremor prediction algorithm can be potentially used for designing the next generation of non-invasive closed-loop predictive ON-OFF controllers for deep brain stimulation (DBS), used for suppressing pathological tremor in such patients. Such a system is based on alternating ON and OFF DBS periods, an incoming tremor being predicted during the time intervals when DBS is OFF, so as to turn DBS back ON. The prediction should be a few seconds before tremor re-appears so that the patient is tremor-free for the entire DBS ON-OFF cycle and the tremor-free DBS OFF interval should be maximized in order to minimize the current injected in the brain and battery usage.

  9. Accelerator control systems in China

    International Nuclear Information System (INIS)

    Three accelerator facilities were built in the past few years, the 2.8 GeV electron positron collider BEPC, the heavy ion SSC cyclotron accelerator HIRFL and the 800 MeV synchrotron radiation storage ring HESYRL. Aimed at different research areas, they represent a new generation of accelerator in China. This report describes the design philosophy, the structure, performance as well as future improvements of the control systems of the these facilities. (author)

  10. Accelerator operations

    International Nuclear Information System (INIS)

    This section is concerned with the operation of both the tandem-linac system and the Dynamitron, two accelerators that are used for entirely different research. Developmental activities associated with the tandem and the Dynamitron are also treated here, but developmental activities associated with the superconducting linac are covered separately because this work is a program of technology development in its own right

  11. Geochemical reactions and dynamics during titration of a contaminated groundwater with high uranium, aluminum, and calcium

    Science.gov (United States)

    Gu, Baohua; Brooks, Scott C.; Roh, Yul; Jardine, Philip M.

    2003-08-01

    This study investigated possible geochemical reactions during titration of a contaminated groundwater with a low pH but high concentrations of aluminum, calcium, magnesium, manganese, and trace contaminant metals/radionuclides such as uranium, technetium, nickel, and cobalt. Both Na-carbonate and hydroxide were used as titrants, and a geochemical equilibrium reaction path model was employed to predict aqueous species and mineral precipitation during titration. Although the model appeared to be adequate to describe the concentration profiles of some metal cations, solution pH, and mineral precipitates, it failed to describe the concentrations of U during titration and its precipitation. Most U (as uranyl, UO 22+) as well as Tc (as pertechnetate, TcO 4-) were found to be sorbed and coprecipitated with amorphous Al and Fe oxyhydroxides at pH below ˜5.5, but slow desorption or dissolution of U and Tc occurred at higher pH values when Na 2CO 3 was used as the titrant. In general, the precipitation of major cationic species followed the order of Fe(OH) 3 and/or FeCo 0.1(OH) 3.2, Al 4(OH) 10SO 4, MnCO 3, CaCO 3, conversion of Al 4(OH) 10SO 4 to Al(OH) 3,am, Mn(OH) 2, Mg(OH) 2, MgCO 3, and Ca(OH) 2. The formation of mixed or double hydroxide phases of Ni and Co with Al and Fe oxyhydroxides was thought to be responsible for the removal of Ni and Co in solution. Results of this study indicate that, although the hydrolysis and precipitation of a single cation are known, complex reactions such as sorption/desorption, coprecipitation of mixed mineral phases, and their dissolution could occur simultaneously. These processes as well as the kinetic constraints must be considered in the design of the remediation strategies and modeling to better predict the activities of various metal species and solid precipitates during pre- and post-groundwater treatment practices.

  12. Correct and efficient accelerator programming

    OpenAIRE

    Cohen, Albert; Donaldson, Alistair F.; Huisman, Marieke; Katoen, Joost-Pieter

    2013-01-01

    This report documents the program and the outcomes of Dagstuhl Seminar 13142 “Correct and Efficient Accelerator Programming”. The aim of this Dagstuhl seminar was to bring together researchers from various sub-disciplines of computer science to brainstorm and discuss the theoretical foundations, design and implementation of techniques and tools for correct and efficient accelerator programming.

  13. Thomas Edison Accelerated Elementary School.

    Science.gov (United States)

    Levin, Henry M.; Chasin, Gene

    This paper describes early outcomes of a Sacramento, California, elementary school that participated in the Accelerated Schools Project. The school, which serves many minority and poor students, began training for the project in 1992. Accelerated Schools were designed to advance the learning rate of students through a gifted and talented approach,…

  14. New directions in linear accelerators

    International Nuclear Information System (INIS)

    Current work on linear particle accelerators is placed in historical and physics contexts, and applications driving the state of the art are discussed. Future needs and the ways they may force development are outlined in terms of exciting R and D challenges presented to today's accelerator designers. 23 references, 7 figures

  15. Design of UAV longitudinal control scheme based on acceleration%基于加速度的无人机纵向控制方案设计

    Institute of Scientific and Technical Information of China (English)

    李道斌

    2015-01-01

    Since the general longitudinal control schemes for UAV has high cost,drastic attitude change and great over-shoot in height tracking,a longitudinal control scheme based on acceleration was designed,and the longitudinal linear motion model of UVA was established. The acceleration-based longitudinal control equationand control block diagram are introduced. The hardware needed for longitudinal control is given. The specific design steps of the control parameters are presented. The mathematical simulation of level flight,climbout and decline was conducted. The simulation results are compared with the mathe-matical simulation results of conventional longitudinal control law. Simulation comparison results show that the proposed scheme has good anti-interference ability,smooth attitude change,high-accuracy height tracking,fast speed and no overshoot,which is suitable for the longitudinal control of various UAVs.%针对无人机常规纵向控制方案成本较高、姿态变化剧烈、高度跟踪超调大的问题,设计一种基于加速度的纵向控制方案.建立了无人机纵向线性运动模型,介绍基于加速度的纵向控制方程和控制框图,给出纵向控制所需的硬件,提出了控制参数设计的具体步骤,进行了平飞、爬升和下降三种状态数学仿真,并与常规的纵向控制数学仿真结果进行了对比.仿真对比表明,基于加速度的纵向控制方案成本抗干扰能力强,姿态变化平稳,高度跟踪精度高、速度快、无超调,适用于各型无人机的纵向控制.

  16. The use of acidimetric titration as a novel approach to study particulate trace metal speciation and mobility: Application to sediments of the Scheldt estuary

    International Nuclear Information System (INIS)

    The study of trace metal speciation has benefited from a great deal of interest leading to the development and the diversification of sequential extraction schemes (SES), which triggered the need for harmonization by the standard, measurements and testing programme (SM and T). However, some uncertainties still persist in the application of the harmonized 3-step protocol, because of the difficulty in conceptualizing a technique that can be applied to environmental samples irrespective of their nature. The alternative method proposed in this study is based on the solubility of the sample components progressively dissolved during the course of an acidimetric titration by 1 mol L-1 HCl. The major HCl-reactive mineralogical components are identified using mass balance calculation of H+ consumed by their dissolution together with the amount of major elements released into solution. The speciation of minor and trace elements is investigated by comparing their titrations to those of the major elements. This approach is much simpler than SES because it uses simple non-selective H+ at room temperature instead of a complex experimental design of so-called specific reagents. The different mineral components of the solid are no longer operationally defined and the problem of selectivity is irrelevant to the titration approach. The method was applied to several sediment samples from the Scheldt estuary and the particulate phase was further examined by Scanning Electron Microprobe and X-ray Diffraction techniques. The nearly complete consumption of H+ in the suspension is balanced by the total dissolution of carbonates and Fe-oxyhydroxides. In contrast to the speciation inferred from the Tessier SES, the acidimetric titration has demonstrated that the carbonate phase does not significantly contain trace metals with the exceptions of 40% of the Mn and 30% of the Co. In contrast, the Fe-oxyhydroxides seem to play a major role and account for 70% of Pb and 20% of Cr, in addition to

  17. Determination of Dimethylallylamine by Titration in Nonaqueous Solvent

    Institute of Scientific and Technical Information of China (English)

    LIU Li-hua; GONG Zhu-qing; ZHENG Ya-jie

    2004-01-01

    The content of dimethylallylamine was determined using glacial acetic acid as solvent, acetic-formic mixture as an anhydrite, perchloric acid-glacial acetic acid as titrant, and 1% crystal violet in acetic acid as indicator in the presence of methylamine and dimethylamine The influences of inert constituents and water on the titration were investigated, and a complete analytical method was determined. The results showed that the determination error of total amines increased with water increasing, while the effect of water on the determination of dimethylallylamine was little when the amount of water was within 5%, the relative error was generally within 1%, and that the end-point was acutely when about 10% chloroform was added. Compared with gas chromatography, this method is simple, convenient and accurate.

  18. Isothermal titration calorimetry of membrane proteins - progress and challenges.

    Science.gov (United States)

    Rajarathnam, Krishna; Rösgen, Jörg

    2014-01-01

    Integral membrane proteins, including G protein-coupled receptors (GPCR) and ion channels, mediate diverse biological functions that are crucial to all aspects of life. The knowledge of the molecular mechanisms, and in particular, the thermodynamic basis of the binding interactions of the extracellular ligands and intracellular effector proteins is essential to understand the workings of these remarkable nanomachines. In this review, we describe how isothermal titration calorimetry (ITC) can be effectively used to gain valuable insights into the thermodynamic signatures (enthalpy, entropy, affinity, and stoichiometry), which would be most useful for drug discovery studies, considering that more than 30% of the current drugs target membrane proteins. This article is part of a Special Issue entitled: Structural and biophysical characterisation of membrane protein-ligand binding.

  19. Sailing on the "C": A Vitamin Titration with a Twist

    Science.gov (United States)

    Sowa, S.; Kondo, A. E.

    2003-05-01

    The experiment takes the traditional redox titration of vitamin C using iodine with starch as an indicator, and presents it to the student as a challenge in guided-inquiry format. Two versions, with different levels of difficulty, are provided, to accommodate students with varying levels of problem-solving skills. The "challenge" is both quantitative and qualitative: if you were an eighteenth-century sea captain packing for a voyage to the New World, would you take oranges, lemons, limes, or grapefruits to prevent your crew from getting scurvy? The challenge ties in history, nutrition, and health with chemistry, and provides students an opportunity to work with familiar food products in the laboratory.

  20. Efficient Isothermal Titration Calorimetry Technique Identifies Direct Interaction of Small Molecule Inhibitors with the Target Protein.

    Science.gov (United States)

    Gal, Maayan; Bloch, Itai; Shechter, Nelia; Romanenko, Olga; Shir, Ofer M

    2016-01-01

    Protein-protein interactions (PPI) play a critical role in regulating many cellular processes. Finding novel PPI inhibitors that interfere with specific binding of two proteins is considered a great challenge, mainly due to the complexity involved in characterizing multi-molecular systems and limited understanding of the physical principles governing PPIs. Here we show that the combination of virtual screening techniques, which are capable of filtering a large library of potential small molecule inhibitors, and a unique secondary screening by isothermal titration calorimetry, a label-free method capable of observing direct interactions, is an efficient tool for finding such an inhibitor. In this study we applied this strategy in a search for a small molecule capable of interfering with the interaction of the tumor-suppressor p53 and the E3-ligase MDM2. We virtually screened a library of 15 million small molecules that were filtered to a final set of 80 virtual hits. Our in vitro experimental assay, designed to validate the activity of mixtures of compounds by isothermal titration calorimetry, was used to identify an active molecule against MDM2. At the end of the process the small molecule (4S,7R)-4-(4-chlorophenyl)-5-hydroxy-2,7-dimethyl-N-(6-methylpyridin-2-yl)-4,6,7,8 tetrahydrIoquinoline-3-carboxamide was found to bind MDM2 with a dissociation constant of ~2 µM. Following the identification of this single bioactive compound, spectroscopic measurements were used to further characterize the interaction of the small molecule with the target protein. 2D NMR spectroscopy was used to map the binding region of the small molecule, and fluorescence polarization measurement confirmed that it indeed competes with p53.

  1. Quick titration of pergolide in cotreatment with domperidone is safe and effective

    NARCIS (Netherlands)

    Jansen, PAF; Herings, RMC; Samson, MM; Schuurmans-Daemen, LMPJ; Hovestadt, A; Verhaar, HJJ; Van Laar, T; de Vreede, P.

    2001-01-01

    The purpose of the study was to analyze efficacy and safety of quick pergolide titration combined with domperidone. In an open-label prospective study, pergolide was titrated in 16 days to a maximum of 3 mg/d doses as adjunctive treatment to L-Dopa in 10 elderly patients with Parkinson's disease. Si

  2. Humic substance charge determination by titration with a flexible cationic polyelectrolyte

    NARCIS (Netherlands)

    Tan, Wen-Feng; Norde, Willem; Koopal, Luuk K.

    2011-01-01

    The anionic charge of humic substances (HS) plays a major role in the interaction of HS with other components. Therefore, the potential of the polyelectrolyte titration technique to obtain the charge density of HS in simple 1-1 electrolyte solutions has been investigated. Titrations are carried out

  3. Humic substance charge determination by titration with a flexible cationic polyelectrolyte

    NARCIS (Netherlands)

    Tan, W.F.; Norde, W.; Koopal, L.K.

    2011-01-01

    The anionic charge of humic substances (HS) plays a major role in the interaction of HS with other components. Therefore, the potential of the polyelectrolyte titration technique to obtain the charge density of HS in simple 1–1 electrolyte solutions has been investigated. Titrations are carried out

  4. The ion-sensitive field effect transistor in rapid acid-base titrations

    NARCIS (Netherlands)

    Bos, M.; Bergveld, P.; Veen-Blaauw, van A.M.W.

    1979-01-01

    Ion-sensitive field effect transistors (ISFETs) are used as the pH sensor in rapid acid—base titrations. Titration speeds at least five times greater than those with glass electrodes are possible for accuracies better than ±1%.

  5. Design of a control system for a macro-micro dual-drive high acceleration high precision positioning stage for IC packaging

    Institute of Scientific and Technical Information of China (English)

    LIU YanJie; LI Teng; SUN LiNing

    2009-01-01

    A macro-micro dual-drive positioning system showing good potential for high acceleration and high precision positioning required in IC packaging applications is devised in this paper. The dual-drive positioning stage uses a VCM (voice coil motor) driven macro positioning stage and a PZT piezo-electric driven micro positioning stage. The coupling characteristics of the system are analyzed to produce a control structure with a micro positioning stage that can dynamically compensate for the positioning error produced by the macro positioning stage. Models of the two positioning stages are described. The models cover both the mechanism and the actuator. For the macro positioning stage,friction characteristics are taken into account, and a controller with an LQG (linear-quadratic-Gaussian)control algorithm combining a feed-forward compensation algorithm is derived. A PID controller is used to control the micro positioning stage. Detailed designs are derived for the proposed approach,and the performance is validated by simulation.

  6. Electrostatic accelerators fundamentals and applications

    CERN Document Server

    2005-01-01

    Electrostatic accelerators are an important and widespread subgroup within the broad spectrum of modern, large particle acceleration devices. They are specifically designed for applications that require high-quality ion beams in terms of energy stability and emittance at comparatively low energies (a few MeV). Their ability to accelerate virtually any kind of ion over a continuously tunable range of energies make them a highly versatile tool for investigations in many research fields including, but not limited to, atomic and nuclear spectroscopy, heavy ion reactions, accelerator mass spectroscopy as well as ion-beam analysis and modification. The book is divided into three parts. The first part concisely introduces the field of accelerator technology and techniques that emphasize their major modern applications. The second part treats the electrostatic accelerator per se: its construction and operational principles as well as its maintenance. The third part covers all relevant applications in which electrosta...

  7. X-ray converter design for an electron linear accelerator%电子直线加速器X射线转换靶设计

    Institute of Scientific and Technical Information of China (English)

    张耀锋; 黄建微; 胡涛; 张明昕; 江艳

    2013-01-01

    设计了用于BF-5电子直线加速器的X射线转换靶.采用蒙特卡罗模拟程序优化计算了靶材厚度;设计了转换靶的冷却结构,并采用有限元方法模拟计算了水冷效果;依据设计的结构参数,计算了转换靶产生X射线的剂量分布及能谱分布.结果表明:靶体温度控制在40℃以下,转换靶在该条件下能够长期稳定工作;X射线平均能量为0.65 MeV,在转换靶正前方1 m处吸收剂量可达6 Gy/min.%The design of an X-ray converter for the BF-5 electron linear accelerator is described.First,the thickness of the converter is optimized by Monte Carlo simulations and the water-cooling structure of the converter is designed.Then,the water cooling process is simulated by finite element analysis and the temperature distribution of the converter is computed.Finally,the dose distribution of the converter as well as the energy spectrum of the generated X-ray is calculated.The results show that the maximal temperature of the converter is below 40 ℃,thus the converter could operate consistently and stably.The mean energy of the generated X-ray is 0.65 MeV,and the absorbed dose of the X-ray for the point 1 meter ahead from the center of the converter could reach 6 Gy/min.

  8. Study and Application of a New On—Line Titration Technique

    Institute of Scientific and Technical Information of China (English)

    朱建育; 施利毅; 等

    2002-01-01

    A new on-line titration method and device based on a new technique-continuous flow titration is described.By the means of electronically controlled switching of a solenoid valve,the main component of the system,the equivalent point of the titration is easily determined.Several kinds of mixing tools were examined.whereby a self-made mixing chamer with minimum volume gave best results and was therefore used in the dveice,The error of the titration is within 0.2% and the relative standard deviation(RSD) is below 1.2%,The results show no difference compared with a commercial device,meanwhile the new on-line titration system is cheaper and fully automated and thus easy to hand and less slovent consumption.

  9. Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions.

    Science.gov (United States)

    Brautigam, Chad A; Zhao, Huaying; Vargas, Carolyn; Keller, Sandro; Schuck, Peter

    2016-05-01

    Isothermal titration calorimetry (ITC) is a powerful and widely used method to measure the energetics of macromolecular interactions by recording a thermogram of differential heating power during a titration. However, traditional ITC analysis is limited by stochastic thermogram noise and by the limited information content of a single titration experiment. Here we present a protocol for bias-free thermogram integration based on automated shape analysis of the injection peaks, followed by combination of isotherms from different calorimetric titration experiments into a global analysis, statistical analysis of binding parameters and graphical presentation of the results. This is performed using the integrated public-domain software packages NITPIC, SEDPHAT and GUSSI. The recently developed low-noise thermogram integration approach and global analysis allow for more precise parameter estimates and more reliable quantification of multisite and multicomponent cooperative and competitive interactions. Titration experiments typically take 1-2.5 h each, and global analysis usually takes 10-20 min.

  10. Accelerating networks

    International Nuclear Information System (INIS)

    Evolving out-of-equilibrium networks have been under intense scrutiny recently. In many real-world settings the number of links added per new node is not constant but depends on the time at which the node is introduced in the system. This simple idea gives rise to the concept of accelerating networks, for which we review an existing definition and-after finding it somewhat constrictive-offer a new definition. The new definition provided here views network acceleration as a time dependent property of a given system as opposed to being a property of the specific algorithm applied to grow the network. The definition also covers both unweighted and weighted networks. As time-stamped network data becomes increasingly available, the proposed measures may be easily applied to such empirical datasets. As a simple case study we apply the concepts to study the evolution of three different instances of Wikipedia, namely, those in English, German, and Japanese, and find that the networks undergo different acceleration regimes in their evolution

  11. Hardware Accelerated Power Estimation

    CERN Document Server

    Coburn, Joel; Raghunathan, Anand

    2011-01-01

    In this paper, we present power emulation, a novel design paradigm that utilizes hardware acceleration for the purpose of fast power estimation. Power emulation is based on the observation that the functions necessary for power estimation (power model evaluation, aggregation, etc.) can be implemented as hardware circuits. Therefore, we can enhance any given design with "power estimation hardware", map it to a prototyping platform, and exercise it with any given test stimuli to obtain power consumption estimates. Our empirical studies with industrial designs reveal that power emulation can achieve significant speedups (10X to 500X) over state-of-the-art commercial register-transfer level (RTL) power estimation tools.

  12. VLHC accelerator physics

    Energy Technology Data Exchange (ETDEWEB)

    Michael Blaskiewicz et al.

    2001-11-01

    A six-month design study for a future high energy hadron collider was initiated by the Fermilab director in October 2000. The request was to study a staged approach where a large circumference tunnel is built that initially would house a low field ({approx}2 T) collider with center-of-mass energy greater than 30 TeV and a peak (initial) luminosity of 10{sup 34} cm{sup -2}s{sup -1}. The tunnel was to be scoped, however, to support a future upgrade to a center-of-mass energy greater than 150 TeV with a peak luminosity of 2 x 10{sup 34} cm{sup -2} sec{sup -1} using high field ({approx} 10 T) superconducting magnet technology. In a collaboration with Brookhaven National Laboratory and Lawrence Berkeley National Laboratory, a report of the Design Study was produced by Fermilab in June 2001. 1 The Design Study focused on a Stage 1, 20 x 20 TeV collider using a 2-in-1 transmission line magnet and leads to a Stage 2, 87.5 x 87.5 TeV collider using 10 T Nb{sub 3}Sn magnet technology. The article that follows is a compilation of accelerator physics designs and computational results which contributed to the Design Study. Many of the parameters found in this report evolved during the study, and thus slight differences between this text and the Design Study report can be found. The present text, however, presents the major accelerator physics issues of the Very Large Hadron Collider as examined by the Design Study collaboration and provides a basis for discussion and further studies of VLHC accelerator parameters and design philosophies.

  13. Accelerators and the Accelerator Community

    Energy Technology Data Exchange (ETDEWEB)

    Malamud, Ernest; Sessler, Andrew

    2008-06-01

    In this paper, standing back--looking from afar--and adopting a historical perspective, the field of accelerator science is examined. How it grew, what are the forces that made it what it is, where it is now, and what it is likely to be in the future are the subjects explored. Clearly, a great deal of personal opinion is invoked in this process.

  14. accelerating cavity

    CERN Multimedia

    On the inside of the cavitytThere is a layer of niobium. Operating at 4.2 degrees above absolute zero, the niobium is superconducting and carries an accelerating field of 6 million volts per metre with negligible losses. Each cavity has a surface of 6 m2. The niobium layer is only 1.2 microns thick, ten times thinner than a hair. Such a large area had never been coated to such a high accuracy. A speck of dust could ruin the performance of the whole cavity so the work had to be done in an extremely clean environment.

  15. Accelerator structure work for NLC

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.H.; Adolphsen, C.; Bane, K.L.F.; Deruyter, H.; Farkas, Z.D.; Hoag, H.A.; Holtkamp, N.; Lavine, T.; Loew, G.A.; Nelson, E.M.; Palmer, R.B.; Paterson, J.M.; Ruth, R.D.; Thompson, K.A.; Vlieks, A.; Wang, J.W.; Wilson, P.B. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Gluckstern, R. [Maryland Univ., College Park, MD (United States); Ko, K.; Kroll, N. [Stanford Linear Accelerator Center, Menlo Park, CA (United States)]|[California Univ., San Diego, La Jolla, CA (United States). Dept. of Physics

    1992-07-01

    The NLC design achieves high luminosity with multiple bunches in each RF pulse. Acceleration of a train of bunches without emittance growth requires control of long range dipole wakefields. SLAC is pursuing a structure design which suppresses the effect of wakefields by varying the physical dimensions of successive cells of the disk-loaded traveling wave structure in a manner which spreads the frequencies of the higher mode while retaining the synchronism between the electrons and the accelerating mode. The wakefields of structures incorporating higher mode detuning have been measured at the Accelerator Test Facility at Argonne. Mechanical design and brazing techniques which avoid getting brazing alloy into the interior of the accelerator are being studied. A test facility for high-power testing of these structures is complete and high power testing has begun.

  16. Characterization of membrane protein interactions by isothermal titration calorimetry.

    Science.gov (United States)

    Situ, Alan J; Schmidt, Thomas; Mazumder, Parichita; Ulmer, Tobias S

    2014-10-23

    Understanding the structure, folding, and interaction of membrane proteins requires experimental tools to quantify the association of transmembrane (TM) helices. Here, we introduce isothermal titration calorimetry (ITC) to measure integrin αIIbβ3 TM complex affinity, to study the consequences of helix-helix preorientation in lipid bilayers, and to examine protein-induced lipid reorganization. Phospholipid bicelles served as membrane mimics. The association of αIIbβ3 proceeded with a free energy change of -4.61±0.04kcal/mol at bicelle conditions where the sampling of random helix-helix orientations leads to complex formation. At bicelle conditions that approach a true bilayer structure in effect, an entropy saving of >1kcal/mol was obtained from helix-helix preorientation. The magnitudes of enthalpy and entropy changes increased distinctly with bicelle dimensions, indicating long-range changes in bicelle lipid properties upon αIIbβ3 TM association. NMR spectroscopy confirmed ITC affinity measurements and revealed αIIbβ3 association and dissociation rates of 4500±100s(-1) and 2.1±0.1s(-1), respectively. Thus, ITC is able to provide comprehensive insight into the interaction of membrane proteins.

  17. Enzyme kinetics determined by single-injection isothermal titration calorimetry.

    Science.gov (United States)

    Transtrum, Mark K; Hansen, Lee D; Quinn, Colette

    2015-04-01

    The purposes of this paper are (a) to examine the effect of calorimeter time constant (τ) on heat rate data from a single enzyme injection into substrate in an isothermal titration calorimeter (ITC), (b) to provide information that can be used to predict the optimum experimental conditions for determining the rate constant (k2), Michaelis constant (KM), and enthalpy change of the reaction (ΔRH), and (c) to describe methods for evaluating these parameters. We find that KM, k2 and ΔRH can be accurately estimated without correcting for the calorimeter time constant, τ, if (k2E/KM), where E is the total active enzyme concentration, is between 0.1/τ and 1/τ and the reaction goes to at least 99% completion. If experimental conditions are outside this domain and no correction is made for τ, errors in the inferred parameters quickly become unreasonable. A method for fitting single-injection data to the Michaelis-Menten or Briggs-Haldane model to simultaneously evaluate KM, k2, ΔRH, and τ is described and validated with experimental data. All four of these parameters can be accurately inferred provided the reaction time constant (k2E/KM) is larger than 1/τ and the data include enzyme saturated conditions.

  18. Predicting proton titration in cationic micelle and bilayer environments

    Energy Technology Data Exchange (ETDEWEB)

    Morrow, Brian H.; Shen, Jana K. [Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland 21201 (United States); Eike, David M.; Murch, Bruce P.; Koenig, Peter H. [Computational Chemistry, Modeling and Simulation GCO, Procter and Gamble, Cincinnati, Ohio 45201 (United States)

    2014-08-28

    Knowledge of the protonation behavior of pH-sensitive molecules in micelles and bilayers has significant implications in consumer product development and biomedical applications. However, the calculation of pK{sub a}’s in such environments proves challenging using traditional structure-based calculations. Here we apply all-atom constant pH molecular dynamics with explicit ions and titratable water to calculate the pK{sub a} of a fatty acid molecule in a micelle of dodecyl trimethylammonium chloride and liquid as well as gel-phase bilayers of diethyl ester dimethylammonium chloride. Interestingly, the pK{sub a} of the fatty acid in the gel bilayer is 5.4, 0.4 units lower than that in the analogous liquid bilayer or micelle, despite the fact that the protonated carboxylic group is significantly more desolvated in the gel bilayer. This work illustrates the capability of all-atom constant pH molecular dynamics in capturing the delicate balance in the free energies of desolvation and Coulombic interactions. It also shows the importance of the explicit treatment of ions in sampling the protonation states. The ability to model dynamics of pH-responsive substrates in a bilayer environment is useful for improving fabric care products as well as our understanding of the side effects of anti-inflammatory drugs.

  19. Predicting proton titration in cationic micelle and bilayer environments

    International Nuclear Information System (INIS)

    Knowledge of the protonation behavior of pH-sensitive molecules in micelles and bilayers has significant implications in consumer product development and biomedical applications. However, the calculation of pKa’s in such environments proves challenging using traditional structure-based calculations. Here we apply all-atom constant pH molecular dynamics with explicit ions and titratable water to calculate the pKa of a fatty acid molecule in a micelle of dodecyl trimethylammonium chloride and liquid as well as gel-phase bilayers of diethyl ester dimethylammonium chloride. Interestingly, the pKa of the fatty acid in the gel bilayer is 5.4, 0.4 units lower than that in the analogous liquid bilayer or micelle, despite the fact that the protonated carboxylic group is significantly more desolvated in the gel bilayer. This work illustrates the capability of all-atom constant pH molecular dynamics in capturing the delicate balance in the free energies of desolvation and Coulombic interactions. It also shows the importance of the explicit treatment of ions in sampling the protonation states. The ability to model dynamics of pH-responsive substrates in a bilayer environment is useful for improving fabric care products as well as our understanding of the side effects of anti-inflammatory drugs

  20. Accelerator Experiments for Astrophysics

    OpenAIRE

    Ng, Johnny S. T.

    2003-01-01

    Many recent discoveries in astrophysics involve phenomena that are highly complex. Carefully designed experiments, together with sophisticated computer simulations, are required to gain insights into the underlying physics. We show that particle accelerators are unique tools in this area of research, by providing precision calibration data and by creating extreme experimental conditions relevant for astrophysics. In this paper we discuss laboratory experiments that can be carried out at the S...

  1. Future Accelerator Magnet Needs

    CERN Document Server

    Devred, Arnaud; Yamamoto, A

    2005-01-01

    Superconducting magnet technology is continually evolving in order to meet the demanding needs of new accelerators and to provide necessary upgrades for existing machines. A variety of designs are now under development, including high fields and gradients, rapid cycling and novel coil configurations. This paper presents a summary of R&D programs in the EU, Japan and the USA. A performance comparison between NbTi and Nb3Sn along with fabrication and cost issues are also discussed.

  2. 沉淀滴定的林邦滴定曲线方程%Ringbom titration curve equation of precipitation titration

    Institute of Scientific and Technical Information of China (English)

    乔成立; 李文新

    2014-01-01

    Ionic strength effect,acid effect,precipitation effect and ligand effect were identified as side reactions of the main reaction,Ringbom titration curve equation of precipitation titration was derived by means of material balance, conditional stability constant and titration scores,etc,which can lay a solid foundation for researching precipitation titration analysis theory on the basis of Ringbom titration curve equation.%把离子强度效应、酸效应、沉淀效应、配位效应等看作是主反应发生的副反应,通过物料平衡、条件稳定常数和滴定分数等推导出沉淀滴定的林邦滴定曲线方程,为用林邦滴定曲线方程研究沉淀滴定分析理论打下坚实的基础。

  3. Researches on automatic pipetting titration system based on Lab VIEW%基于LabVIEW的自动移液滴定系统研究

    Institute of Scientific and Technical Information of China (English)

    徐昊; 许国根; 王幸运

    2012-01-01

    The article designs a automatic pipetting titration system based on LabVIEW software platform and data acquisition card. This system applies three different software control methods and combines with the motor subdivision module to control the two-phase and through shaft stepper motor pulse frequency, duty cycle and the step angle, so as to achieve the purpose of accurate pipetting and titration. This article introduced two different software control methods and compared with the advantages and disadvantages of the them. Compared with the traditional singlechip controlling titration system, the system has a good software interface, a simple program, and easy to upgrade the development. When used in liquid pro-pellant titration analysis of the experiments the operation effect is good and the titration accuracy is up to 99.94%.%本文设计了基于LabVIEW软件平台和数据采集卡的自动移液滴定系统.系统应用3种不同的软件控制方法,结合电机细分控制.对两相贯通轴步进电机的脉冲频率、占空比和步进角度等进行控制,从而达到精确移液滴定的目的.着重介绍了两种不同的软件控制方法,并比较两种控制方式的优缺点.与传统单片机控制滴定系统相比,该系统具有良好的软件交互界面,程序简洁,易于升级开发等优点.应用于液体推进剂滴定分析实验中,滴定精度可达99.94%,运行效果良好.

  4. Titration of intravenous synthetic oxytocin post vaginal birth following induction or augmentation.

    Science.gov (United States)

    Lewis, Lucy; Hauck, Yvonne L; Pemberton, Alissa; Crichton, Caroline; Conwell, Marion

    2016-10-01

    Evidence exists for titration of intravenous oxytocin during induction and augmentation, whereas no evidence was identified for titration of intravenous oxytocin following vaginal birth, where management excluded oxytocin for postpartum haemorrhage (PPH). This retrospective cohort study explored this issue through patient case notes and computerised perinatal data. Analysis included 335 women comparing induction (n = 226, 67%) to augmentation (n = 109, 33%). The two groups differed in terms of: parity; oxytocin dosage; length of time on intravenous oxytocin; and the length of first and second stage labour. They had similar rates of PPH and titration of intravenous oxytocin following birth was rarely recorded. PMID:27634662

  5. Comparative Study of the Total Acidity Determination in Wine by Potentiometric and Volumetric Titration

    OpenAIRE

    Budić-Leto, Irena; Mešin, Nela; Gajdoš Kljusurić, Jasenka; Pezo, Ivan; Bralić, Marija

    2009-01-01

    Total acidity was determined in thirty-seven samples of Croatian red, white and rosé wines by potentiometric titration. In order to find the effect of the corresponding rate of the automatic titrant added, several procedures were employed. For different rates of titration, the aberrances were found from 0.1 to 0.4 g L–1 for some wines. The value of the total acid content in wine determined by the automatic potentiometric titration method was compared to that obtained by the conventional volum...

  6. On the Physical Meaning of the Isothermal Titration Calorimetry Measurements in Calorimeters with Full Cells

    Science.gov (United States)

    Grolier, Jean-Pierre E.; del Río, Jose Manuel

    2009-01-01

    We have performed a detailed study of the thermodynamics of the titration process in an isothermal titration calorimeter with full cells. We show that the relationship between the enthalpy and the heat measured is better described in terms of the equation Δ H = Winj + Q (where Winj is the work necessary to carry out the titration) than in terms of ΔH = Q. Moreover, we show that the heat of interaction between two components is related to the partial enthalpy of interaction at infinite dilution of the titrant component, as well as to its partial volume of interaction at infinite dilution. PMID:20054472

  7. Titration Calorimetry Applied to the Thermokinetics Study of Consecutive First-order Reactions

    Institute of Scientific and Technical Information of China (English)

    SHI Jing-Yan; LI Jie; WANG Zhi-Yong; LIU Yu-Wen; WANG Cun-Xin

    2008-01-01

    The thermokinetic mathematical models for consecutive first-order reactions in titration period and the stopped-titration reaction period were proposed for titration calorimetry, based on which, thermodynamic parameters (reaction enthalpies, △rHm1 and △rHm2) and kinetic parameters (rate constants, k1 and k2) of the consecutive first-order reactions could be obtained by directly simulating the calorimetric curve from a single experiment with the method of nonlinear least squares regression (NLLS).The reliability of the model has been verified by investigating the reaction of the saponification of diethyl succinate in an aqueous ethanol solvent.

  8. Heavy ion accelerators at GSI

    International Nuclear Information System (INIS)

    The status of the Unilac heavy ion linear accelerator at GSI, Darmstadt is given. A schematic overall plan view of the Unilac is shown and its systems are described. List of isotopes and intensities accelerated at the Unilac is presented. The experimental possibilities at GSI should be considerably extended by a heavy ion synchrotron (SIS 18) in combination with an experimental storage ring (ESR). A prototype of the rf-accelerating system of the synchrotron has been built and tested. Prototypes for the quadrupole and dipole magnets for the ring are being constructed. The SIS 18 is desigmed for a maximum magnetic rigidity of 18Tm so that neon can be accelerated to 2 GeV/W and uranium to 1 GeV/u. The design allows also the acceleration of protons up to 4.5 GeV. The ESR permits to storage fully stripped uranium ions up to an energy of approximately R50 MeV/u

  9. 混合离子的沉淀准确滴定%Precipitation Titration for Multiple Ions

    Institute of Scientific and Technical Information of China (English)

    乔成立

    2016-01-01

    The absolute value of titration break in precipitation titration is deduced with the Ringbom titration curve equation, and the conditions for accurate precipitation titration are thus deduced with the absolute value of the titration break.%用沉淀滴定的林邦滴定曲线方程推导滴定突跃的绝对值,用滴定突跃的绝对值推导混合离子准确滴定的条件。

  10. Simple home-made sensors for potentiometric titrations. [Nitroform CH(NO/sub 2/)/sub 3/

    Energy Technology Data Exchange (ETDEWEB)

    Selig, W.

    1982-04-01

    A sensor for potentiometric titrations was prepared by coating a spectroscopic graphite rod with a solution of poly(vinyl chloride) and dioctyphthalate in tetrahydrofuran. The reference electrode was an Ag/AgCl single-junction electrode. The sensor was used in precipitation, acid-base, compleximetric, and redox titrations. Preparation of the coated-graphite sensor is simple and rapid. Moreover, it is quite inexpensive. A limitation is its applicability in aqueous media only, because organic solvents will dissolve the membrane. Various uncoated types of graphite have also been investigated as sensors, particularly in two applications of interest in the analysis of propellants: the titration of nitroform and perchlorate. Obviously, these sensors can be used also in nonaqueous, or partially nonaqueous media. These sensors may also find use in the potentiometric titration of fluoride vs La(III) or Th(IV).

  11. Comparative Study of the Total Acidity Determination in Wine by Potentiometric and Volumetric Titration

    Directory of Open Access Journals (Sweden)

    Irena Budić-leto

    2009-03-01

    Full Text Available Total acidity was determined in thirty-seven samples of Croatian red, white and rosé wines by potentiometric titration. In order to find the effect of the corresponding rate of the automatic titrant added, several procedures were employed. For different rates of titration, the aberrances were found from 0.1 to 0.4 g L–1 for some wines. The value of the total acid content in wine determined by the automatic potentiometric titration method was compared to that obtained by the conventional volumetric titration method. The ANOVA and cluster analysis (CA were applied to detect possible resemblance. The results of total acidity depended on the methods used. However, a good correlation between the results by these methods was found.

  12. CESR Test Accelerator

    CERN Document Server

    Rubin, David L

    2013-01-01

    The Cornell Electron Storage Ring (CESR) was reconfigured in 2008 as a test accelerator to investigate the physics of ultra-low emittance damping rings. During the approximately 40 days/year available for dedicated operation as a test accelerator, specialized instrumentation is used to measure growth and mitigation of the electron cloud, emittance growth due to electron cloud, intra-beam scattering, and ions, and single and multi-bunch instabilities generated by collective effects. The flexibility of the CESR guide field optics and the integration of accelerator modeling codes with the control system have made possible an extraordinary range of experiments. Findings at CesrTA with respect to electron cloud effects, emittance tuning techniques, and beam instrumentation for measuring electron cloud, beam sizes, and beam positions are the basis for much of the design of the ILC damping rings as documented in the ILC-Technical Design Report. The program has allowed the Cornell group to cultivate the kind of talen...

  13. Application of Ion-Association Titration for the Assay of Cyproheptadine Hydrochloride in Pharmaceuticals

    OpenAIRE

    kanakapura Basavaiah; Raghu, Madihalli S.

    2012-01-01

    Two simple and rapid titrimetric methods are described for the determination of cyproheptadine hydrochloride (CPH) in pharmaceuticals. The proposed methods are based on the solvent extraction-titration of CPH with two ion association reagents, sodium lauryl sulphate (SLS), (method A), and tetraphenylborate (TPB), (method B). In method A, SLS was used as titrant and the titration was carried out in the presence of dilute sulphuric acid and chloroform using dimethyl yellow as indicator, whereas...

  14. Polyelectrolyte assisted charge titration spectrometry: applications to latex and oxide nanoparticles

    OpenAIRE

    Mousseau, F.; Vitorazi, L.; Herrmann, L.; S Mornet; Berret, J. -F.

    2016-01-01

    The electrostatic charge density of particles is of paramount importance for the control of the dispersion stability. Conventional methods use potentiometric, conductometric or turbidity titration but require large amount of samples. Here we report a simple and cost-effective method called polyelectrolyte assisted charge titration spectrometry or PACTS. The technique takes advantage of the propensity of oppositely charged polymers and particles to assemble upon mixing, leading to aggregation ...

  15. Use of Terminalia catappa fruit extract as an indicator in acid-base titrations

    Directory of Open Access Journals (Sweden)

    Untwal L

    2006-01-01

    Full Text Available Terminalia catappa L. (tropical almond, family Combretaceae, is a large deciduous tree, originally from India. It thrives as an ornamental tree in many tropical cities of the world. The present work highlights the use of the acidified methanol extract of the outer cover of Terminalia catappa fruits as an acid-base indicator in different types of acid-base titrations. It is found to be a very useful, economical, simple, and accurate indicator for said titrations.

  16. A practical protocol for titrating "optimal" PEEP in acute lung injury: recruitment maneuver and PEEP decrement.

    OpenAIRE

    Suh, Gee Young; Kwon, O Jung; Yoon, Jong Wook; Park, Sang Joon; Ham, Hyoung Suk; Kang, Soo Jung; Koh, Won-Jung; Chung, Man Pyo; Kim, Ho Joong

    2003-01-01

    This study was conducted to evaluate the effectiveness and safety of a practical protocol for titrating positive end-expiratory pressure (PEEP) involving recruitment maneuver (RM) and decremental PEEP. Seventeen consecutive patients with acute lung injury who underwent PEEP titration were included in the analysis. After baseline ventilation, RM (continuous positive airway pressure, 35 cm H2O for 45 sec) was performed and PEEP was increased to 20 cmH2O or the highest PEEP guaranteeing the mini...

  17. Post-LHC accelerator magnets

    Energy Technology Data Exchange (ETDEWEB)

    Gourlay, Stephen A.

    2001-06-10

    The design and practicality of future accelerators, such as hadron colliders and neutrino factories being considered to supercede the LHC, will depend greatly on the choice of superconducting magnets. Various possibilities will be reviewed and discussed, taking into account recent progress and projected improvements in magnet design and conductor development along with the recommendations from the 2001 Snowmass workshop.

  18. The Beta Tech electron accelerator

    International Nuclear Information System (INIS)

    After describing the background of the Swedish Electron Sterilization Centre, the proposed linear accelerator sterilization plant is outlined. The accelerator will produce electrons of energy 10 MeV and a beam power of 30 KW. The handling system, control and identification systems are also described. Documentation will be designed around a bar code system on line to a computer. The various uses of dosimetry in plant performance and process control are described. (U.K.)

  19. Hardware Accelerated Simulated Radiography

    Energy Technology Data Exchange (ETDEWEB)

    Laney, D; Callahan, S; Max, N; Silva, C; Langer, S; Frank, R

    2005-04-12

    We present the application of hardware accelerated volume rendering algorithms to the simulation of radiographs as an aid to scientists designing experiments, validating simulation codes, and understanding experimental data. The techniques presented take advantage of 32 bit floating point texture capabilities to obtain validated solutions to the radiative transport equation for X-rays. An unsorted hexahedron projection algorithm is presented for curvilinear hexahedra that produces simulated radiographs in the absorption-only regime. A sorted tetrahedral projection algorithm is presented that simulates radiographs of emissive materials. We apply the tetrahedral projection algorithm to the simulation of experimental diagnostics for inertial confinement fusion experiments on a laser at the University of Rochester. We show that the hardware accelerated solution is faster than the current technique used by scientists.

  20. Particle accelerator physics

    CERN Document Server

    Wiedemann, Helmut

    2015-01-01

    This book by Helmut Wiedemann is a well-established, classic text, providing an in-depth and comprehensive introduction to the field of high-energy particle acceleration and beam dynamics. The present 4th edition has been significantly revised, updated and expanded. The newly conceived Part I is an elementary introduction to the subject matter for undergraduate students. Part II gathers the basic tools in preparation of a more advanced treatment, summarizing the essentials of electrostatics and electrodynamics as well as of particle dynamics in electromagnetic fields. Part III is an extensive primer in beam dynamics, followed, in Part IV, by an introduction and description of the main beam parameters and including a new chapter on beam emittance and lattice design. Part V is devoted to the treatment of perturbations in beam dynamics. Part VI then discusses the details of charged particle acceleration. Parts VII and VIII introduce the more advanced topics of coupled beam dynamics and describe very intense bea...

  1. Accelerators for Cancer Therapy

    Science.gov (United States)

    Lennox, Arlene J.

    2000-05-30

    The vast majority of radiation treatments for cancerous tumors are given using electron linacs that provide both electrons and photons at several energies. Design and construction of these linacs are based on mature technology that is rapidly becoming more and more standardized and sophisticated. The use of hadrons such as neutrons, protons, alphas, or carbon, oxygen and neon ions is relatively new. Accelerators for hadron therapy are far from standardized, but the use of hadron therapy as an alternative to conventional radiation has led to significant improvements and refinements in conventional treatment techniques. This paper presents the rationale for radiation therapy, describes the accelerators used in conventional and hadron therapy, and outlines the issues that must still be resolved in the emerging field of hadron therapy.

  2. Titration of strong and weak acids by sequential injection analysis technique.

    Science.gov (United States)

    Maskula, S; Nyman, J; Ivaska, A

    2000-05-31

    A sequential injection analysis (SIA) titration method has been developed for acid-base titrations. Strong and weak acids in different concentration ranges have been titrated with a strong base. The method is based on sequential aspiration of an acidic sample zone and only one zone of the base into a carrier stream of distilled water. On their way to the detector, the sample and the reagent zones are partially mixed due to the dispersion and thereby the base is partially neutralised by the acid. The base zone contains the indicator. An LED-spectrophotometer is used as detector. It senses the colour of the unneutralised base and the signal is recorded as a typical SIA peak. The peak area of the unreacted base was found to be proportional to the logarithm of the acid concentration. Calibration curves with good linearity were obtained for a strong acid in the concentration ranges of 10(-4)-10(-2) and 0.1-3 M. Automatic sample dilution was implemented when sulphuric acid at concentration of 6-13 M was titrated. For a weak acid, i.e. acetic acid, a linear calibration curve was obtained in the range of 3x10(-4)-8x10(-2) M. By changing the volumes of the injected sample and the reagent, different acids as well as different concentration ranges of the acids can be titrated without any other adjustments in the SIA manifold or the titration protocol. PMID:18967966

  3. Inferior Turbinate Size and CPAP Titration Based Treatment Pressures: No Association Found among Patients Who Have Not Had Nasal Surgery

    Directory of Open Access Journals (Sweden)

    Macario Camacho

    2016-01-01

    Full Text Available Objective. To evaluate the effect of turbinate sizes on the titrated continuous positive airway pressure (CPAP therapeutic treatment pressures for patients with obstructive sleep apnea (OSA who have not had nasal surgery. Study Design. Retrospective case series. Methods. A chart review was performed for 250 consecutive patients. Results. 45 patients met inclusion criteria. The mean ± standard deviation (M ± SD for age was 54.6±22.4 years and for body mass index was 28.5±5.9 kg/m2. The Spearman’s rank correlation coefficient (rs between CPAP therapeutic treatment pressures and several variables were calculated and were weakly correlated (age rs=0.29, nasal obstruction rs=-0.30, moderately correlated (body mass index rs=0.42 and lowest oxygen saturation rs=-0.47, or strongly correlated (apnea-hypopnea index rs=0.60 and oxygen desaturation index (rs=0.62. No statistical significance was found with one-way analysis of variance (ANOVA between CPAP therapeutic treatment pressures and inferior turbinate size (right turbinates p value = 0.2012, left turbinate p value = 0.3064, nasal septal deviation (p value = 0.4979, or mask type (p value = 0.5136. Conclusion. In this study, CPAP titration based therapeutic treatment pressures were not found to be associated with inferior turbinate sizes; however, the CPAP therapeutic treatment pressures were strongly correlated with apnea-hypopnea index and oxygen desaturation index.

  4. Inferior Turbinate Size and CPAP Titration Based Treatment Pressures: No Association Found among Patients Who Have Not Had Nasal Surgery

    Science.gov (United States)

    Camacho, Macario; Zaghi, Soroush; Tran, Daniel; Song, Sungjin A.; Chang, Edward T.; Certal, Victor

    2016-01-01

    Objective. To evaluate the effect of turbinate sizes on the titrated continuous positive airway pressure (CPAP) therapeutic treatment pressures for patients with obstructive sleep apnea (OSA) who have not had nasal surgery. Study Design. Retrospective case series. Methods. A chart review was performed for 250 consecutive patients. Results. 45 patients met inclusion criteria. The mean ± standard deviation (M ± SD) for age was 54.6 ± 22.4 years and for body mass index was 28.5 ± 5.9 kg/m2. The Spearman's rank correlation coefficient (rs) between CPAP therapeutic treatment pressures and several variables were calculated and were weakly correlated (age rs = 0.29, nasal obstruction rs = −0.30), moderately correlated (body mass index rs = 0.42 and lowest oxygen saturation rs = −0.47), or strongly correlated (apnea-hypopnea index rs = 0.60 and oxygen desaturation index (rs = 0.62)). No statistical significance was found with one-way analysis of variance (ANOVA) between CPAP therapeutic treatment pressures and inferior turbinate size (right turbinates p value = 0.2012, left turbinate p value = 0.3064), nasal septal deviation (p value = 0.4979), or mask type (p value = 0.5136). Conclusion. In this study, CPAP titration based therapeutic treatment pressures were not found to be associated with inferior turbinate sizes; however, the CPAP therapeutic treatment pressures were strongly correlated with apnea-hypopnea index and oxygen desaturation index. PMID:26904126

  5. Isoperibolic Titration Calorimetry as a Tool for the Prediction of Thermodynamic Properties of Cyclodextrins

    Directory of Open Access Journals (Sweden)

    Liliana Giraldo

    2008-10-01

    Full Text Available The interaction of guest molecules ranging from pentan-1-ol to octan-1-ol with α-cyclodextrin (α-CD in water of has been studied calorimetrically at 283.15, 288.15, 293.15, 298.15 and 308.15 K with an isoperibolic titration calorimeter designed in our laboratory. The calorimetric method employed allows the determination of the thermodynamic parameters characterizing the binding process, ΔG°m, ΔH°m, ΔS°mand ΔCp°, namely free energy, enthalpy, and calorific capacity. These results show that in the temperature range investigated, the entropy change increased with chain length. This is in line with what is expected for a hydrophobic dehydration process. However, that effect is not expected to lead to the more pronounced negative CH2-increment observed for nc > 5 or 6. As for many other ligand binding processes, we can observe a significant enthalpy - entropy compensation for this system, both with respect to temperature and structure.

  6. Isoperibolic titration calorimetry as a tool for the prediction of thermodynamic properties of cyclodextrins

    Energy Technology Data Exchange (ETDEWEB)

    Moreno-Pirajan, J. C. [Universidad de los Andes, Bogota, Grupo de investigacion en solidos porosos y calorimetria, Departamento de Quimica, Facultad de Ciencias / Carrera 1 No.18 A10, Bogota (Colombia); Giraldo, L. [Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Quimica / Ciudad Universitaria, Bogota (Colombia)

    2008-07-01

    The interaction of guest molecules ranging from pentan-1-ol to octan-1-ol with {alpha}-cyclodextrin ({alpha}-CD) in water of has been studied calorimetrically at 283.15, 288.15, 293.15, 298.15 and 308.15 K with an isoperibolic titration calorimeter designed in our laboratory. The calorimetric method employed allows the determination of the thermodynamic parameters characterizing the binding process, {delta}G {sup o}{sub m}, {delta}H {sup o}{sub m}, {delta}S {sup o}{sub m} and {delta}Cp {sup o}, namely free energy, enthalpy, and calorific capacity. These results show that in the temperature range investigated, the entropy change increased with chain length. This is in line with what is expected for a hydrophobic dehydration process. However, that effect is not expected to lead to the more pronounced negative CH{sub 2}-increment observed for n{sub c} > 5 or 6. As for many other ligand binding processes, we can observe a significant enthalpy - entropy compensation for this system, both with respect to temperature and structure. (author)

  7. Preparation and Application of Automatic Photometric Titration Analyzer Based on Reflective Photometric Sensor%基于反射式光度传感器的自动光度滴定仪的研制及应用

    Institute of Scientific and Technical Information of China (English)

    何艺; 周小锋; 马建丰

    2012-01-01

    研制了一种以颜色变化为滴定终点的自动光度滴定仪,仪器以光度传感器为核心,包括光度探头、滴定装置、AT89S52单片机、电磁阀、二极管和磁力搅拌器等部件。传感器采用开放设计,对溶液吸光度变化反应迅速。仪器用于红醋酸度的测定,所得结果与电位滴定分析法结果相符。%An automatic photometric titration analyzer with color change as end point of titration was prepared. The analyzer consisted of reflective photometric sensor (as core), photometric probe, titration device, AT89S52 monolithic circuit, electromagnetic valve, diode and magnetic stirrer. The open design of sensor leaded to detect the absorbance of solution without delay in titration. The analyzer was applied in the determination of acidity of red vinegar, and the results obtained were in consistency with those obtained by potentiometric titration.

  8. Accelerator physics issues at the SSC

    Energy Technology Data Exchange (ETDEWEB)

    Dugan, G.F.

    1993-05-01

    Realization of the design energy and luminosity goals of the Superconducting Super Collider (SSC) will require proper resolutions of a number of challenging problems in accelerator physics. The status of several salient issues in the design of the SSC will be reviewed and updated in this paper. The emphasis will be on the superconducting accelerators.

  9. 2014 CERN Accelerator Schools: Beam Loss and Accelerator Protection

    CERN Multimedia

    2014-01-01

    The US-CERN-JAPAN-RUSSIA Joint International Accelerator School is organising a course on Beam Loss and Accelerator Protection to be held in Newport Beach, California, USA from 5-14 November, 2014.    This school is intended for physicists and engineers who are or may be engaged in the design, construction, and/or operation of accelerators with high power photon or particle beams and/or accelerator sub-systems with large stored energy. Application deadlines are 15 August and 4 September. Further information on this Joint School can be found at: http://cas.web.cern.ch/cas/JAS/Newport%20Beach%202014/NPBadvert.html http://indico.cern.ch/event/287647/ http://uspas.fnal.gov/programs/JAS/JAS14.shtml

  10. Wandering accelerators throughout my life (2)

    International Nuclear Information System (INIS)

    My wandering about accelerator started from a van de Graaff accelerator on the Nakanoshima campus of Osaka University. The accelerator was originally designed by Prof. K. Husimi before the World-War II, and completed by Prof. K. Sugimoto, under the severe financial difficulties after the war. It was almost totally handmade, and consequently we were very well trained through various experiences fighting with difficulties. After finishing thesis work, I moved to Berkeley and enjoyed heavy-ion experiments at the world best heavy-ion accelerator, HILAC. The heavy-ion accelerator revealed new facets of nuclei through studies of high-spin states and phenomena. (author)

  11. Accelerator Technology Division progress report, FY 1992

    Energy Technology Data Exchange (ETDEWEB)

    Schriber, S.O.; Hardekopf, R.A.; Heighway, E.A.

    1993-07-01

    This report briefly discusses the following topics: The Ground Test Accelerator Program; Defense Free-Electron Lasers; AXY Programs; A Next Generation High-Power Neutron-Scattering Facility; JAERI OMEGA Project and Intense Neutron Sources for Materials Testing; Advanced Free-Electron Laser Initiative; Superconducting Supercollider; The High-Power Microwave (HPM) Program; Neutral Particle Beam (NPB) Power Systems Highlights; Industrial Partnering; Accelerator Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Accelerator Design and Engineering; Radio-Frequency Technology; Accelerator Theory and Free-Electron Laser Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operations.

  12. Accelerator Technology Division annual report, FY 1991

    International Nuclear Information System (INIS)

    This report discusses the following programs: The Ground Test Accelerator Program; APLE Free-Electron Laser Program; Accelerator Transmutation of Waste; JAERI, OMEGA Project, and Intense Neutron Source for Materials Testing; Advanced Free-Electron Laser Initiative; Superconducting Super Collider; The High-Power Microwave Program; Φ Factory Collaboration; Neutral Particle Beam Power System Highlights; Accelerator Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Accelerator Design and Engineering; Radio-Frequency Technology; Free-Electron Laser Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operations

  13. Accelerator Technology Division progress report, FY 1992

    International Nuclear Information System (INIS)

    This report briefly discusses the following topics: The Ground Test Accelerator Program; Defense Free-Electron Lasers; AXY Programs; A Next Generation High-Power Neutron-Scattering Facility; JAERI OMEGA Project and Intense Neutron Sources for Materials Testing; Advanced Free-Electron Laser Initiative; Superconducting Supercollider; The High-Power Microwave (HPM) Program; Neutral Particle Beam (NPB) Power Systems Highlights; Industrial Partnering; Accelerator Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Accelerator Design and Engineering; Radio-Frequency Technology; Accelerator Theory and Free-Electron Laser Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operations

  14. APT accelerator. Topical report

    International Nuclear Information System (INIS)

    The Accelerator Production of Tritium (APT) project, sponsored by Department of Energy Defense Programs (DOE/DP), involves the preconceptual design of an accelerator system to produce tritium for the nation's stockpile of nuclear weapons. Tritium is an isotope of hydrogen used in nuclear weapons, and must be replenished because of radioactive decay (its half-life is approximately 12 years). Because the annual production requirements for tritium has greatly decreased since the end of the Cold War, an alternative approach to reactors for tritium production, based on a linear accelerator, is now being seriously considered. The annual tritium requirement at the time this study was undertaken (1992-1993) was 3/8 that of the 1988 goal, usually stated as 3/8-Goal. Continued reduction in the number of weapons in the stockpile has led to a revised (lower) production requirement today (March, 1995). The production requirement needed to maintain the reduced stockpile, as stated in the recent Nuclear Posture Review (summer 1994) is approximately 3/16-Goal, half the previous level. The Nuclear Posture Review also requires that the production plant be designed to accomodate a production increase (surge) to 3/8-Goal capability within five years, to allow recovery from a possible extended outage of the tritium plant. A multi-laboratory team, collaborating with several industrial partners, has developed a preconceptual APT design for the 3/8-Goal, operating at 75% capacity. The team has presented APT as a promising alternative to the reactor concepts proposed for Complex-21. Given the requirements of a reduced weapons stockpile, APT offers both significant safety, environmental, and production-fexibility advantages in comparison with reactor systems, and the prospect of successful development in time to meet the US defense requirements of the 21st Century

  15. APT accelerator. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, G.; Rusthoi, D. [comp.] [ed.

    1995-03-01

    The Accelerator Production of Tritium (APT) project, sponsored by Department of Energy Defense Programs (DOE/DP), involves the preconceptual design of an accelerator system to produce tritium for the nation`s stockpile of nuclear weapons. Tritium is an isotope of hydrogen used in nuclear weapons, and must be replenished because of radioactive decay (its half-life is approximately 12 years). Because the annual production requirements for tritium has greatly decreased since the end of the Cold War, an alternative approach to reactors for tritium production, based on a linear accelerator, is now being seriously considered. The annual tritium requirement at the time this study was undertaken (1992-1993) was 3/8 that of the 1988 goal, usually stated as 3/8-Goal. Continued reduction in the number of weapons in the stockpile has led to a revised (lower) production requirement today (March, 1995). The production requirement needed to maintain the reduced stockpile, as stated in the recent Nuclear Posture Review (summer 1994) is approximately 3/16-Goal, half the previous level. The Nuclear Posture Review also requires that the production plant be designed to accomodate a production increase (surge) to 3/8-Goal capability within five years, to allow recovery from a possible extended outage of the tritium plant. A multi-laboratory team, collaborating with several industrial partners, has developed a preconceptual APT design for the 3/8-Goal, operating at 75% capacity. The team has presented APT as a promising alternative to the reactor concepts proposed for Complex-21. Given the requirements of a reduced weapons stockpile, APT offers both significant safety, environmental, and production-fexibility advantages in comparison with reactor systems, and the prospect of successful development in time to meet the US defense requirements of the 21st Century.

  16. Titrated flow versus fixed flow Bubble Nasal CPAP for respiratory distress in preterm neonates.

    Directory of Open Access Journals (Sweden)

    Srinivas eMurki

    2015-10-01

    Full Text Available Background: The clinical effects of a pre-fixed flow of air-oxygen versus a flow titrated according to visible bubbling are not well understood.Objective: To compare the effects of a fixed flow (5 L/min and titrated flow ( flow just enough to ensure bubbling at different set pressures on delivered intra-prong pressure, gas exchange and clinical parameters in preterm infants on bubble CPAP for respiratory distress.Methods: Preterm infants less than 35 weeks gestation on bubble CPAP and less than 96 h of age, were enrolled in this cross over study. They were subjected to 30 minute periods of titrated flow and fixed flow. At the end of both epochs, gas flow rate, set pressure, FiO2, SpO2, Silverman retraction score, respiratory rate , abdominal girth, and blood gases were recorded. The delivered intra-prong pressure was measured by an electronic manometer. Results: Sixty nine recordings were made in 54 infants. For each of the set CPAP pressures (4, 5 and 6 cm H2O, the mean delivered pressure with a fixed flow of 5 L/min was higher than that delivered by the titrated flow. During the fixed flow epoch, the delivered pressure was closer to and higher than the set pressure resulting in higher PaO2 and lower PaCO2 as compared to titrated flow epoch. In the titrated flow period, the delivered pressure was consistently lower than the set pressure. Conclusion: In preterm infants on bubble CPAP with set pressures of 4 to 6 cm H2O, a fixed flow of 5 L/min is more effective than a flow titrated to ensure adequate visible bubbling. It achieves higher delivered pressures, better oxygenation and ventilation.

  17. Berkeley Proton Linear Accelerator

    Science.gov (United States)

    Alvarez, L. W.; Bradner, H.; Franck, J.; Gordon, H.; Gow, J. D.; Marshall, L. C.; Oppenheimer, F. F.; Panofsky, W. K. H.; Richman, C.; Woodyard, J. R.

    1953-10-13

    A linear accelerator, which increases the energy of protons from a 4 Mev Van de Graaff injector, to a final energy of 31.5 Mev, has been constructed. The accelerator consists of a cavity 40 feet long and 39 inches in diameter, excited at resonance in a longitudinal electric mode with a radio-frequency power of about 2.2 x 10{sup 6} watts peak at 202.5 mc. Acceleration is made possible by the introduction of 46 axial "drift tubes" into the cavity, which is designed such that the particles traverse the distance between the centers of successive tubes in one cycle of the r.f. power. The protons are longitudinally stable as in the synchrotron, and are stabilized transversely by the action of converging fields produced by focusing grids. The electrical cavity is constructed like an inverted airplane fuselage and is supported in a vacuum tank. Power is supplied by 9 high powered oscillators fed from a pulse generator of the artificial transmission line type.

  18. High-Intensity Proton Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Jay L. Hirshfield

    2011-12-27

    Analysis is presented for an eight-cavity proton cyclotron accelerator that could have advantages as compared with other accelerators because of its potentially high acceleration gradient. The high gradient is possible since protons orbit in a sequence of TE111 rotating mode cavities of equally diminishing frequencies with path lengths during acceleration that greatly exceed the cavity lengths. As the cavities operate at sequential harmonics of a basic repetition frequency, phase synchronism can be maintained over a relatively wide injection phase window without undue beam emittance growth. It is shown that use of radial vanes can allow cavity designs with significantly smaller radii, as compared with simple cylindrical cavities. Preliminary beam transport studies show that acceptable extraction and focusing of a proton beam after cyclic motion in this accelerator should be possible. Progress is also reported on design and tests of a four-cavity electron counterpart accelerator for experiments to study effects on beam quality arising from variations injection phase window width. This device is powered by four 500-MW pulsed amplifiers at 1500, 1800, 2100, and 2400 MHz that provide phase synchronous outputs, since they are driven from a with harmonics derived from a phase-locked 300 MHz source.

  19. Community Petascale Project for Accelerator Science and Simulation: Advancing Computational Science for Future Accelerators and Accelerator Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Spentzouris, P.; /Fermilab; Cary, J.; /Tech-X, Boulder; McInnes, L.C.; /Argonne; Mori, W.; /UCLA; Ng, C.; /SLAC; Ng, E.; Ryne, R.; /LBL, Berkeley

    2011-11-14

    The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors. ComPASS is in the first year of executing its plan to develop the next-generation HPC accelerator modeling tools. ComPASS aims to develop an integrated simulation environment that will utilize existing and new accelerator physics modules with petascale capabilities, by employing modern computing and solver technologies. The ComPASS vision is to deliver to accelerator scientists a virtual accelerator and virtual prototyping modeling environment, with the necessary multiphysics, multiscale capabilities. The plan for this development includes delivering accelerator modeling applications appropriate for each stage of the ComPASS software evolution. Such applications are already being used to address challenging problems in accelerator design and optimization. The ComPASS organization

  20. Linear Accelerator (LINAC)

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Linear Accelerator A linear accelerator (LINAC) customizes high energy x-rays to ... ensured? What is this equipment used for? A linear accelerator (LINAC) is the device most commonly used ...