Software Tools | Office of Cancer Clinical Proteomics Research

Science.gov (United States)

The CPTAC program develops new approaches to elucidate aspects of the molecular complexity of cancer made from large-scale proteogenomic datasets, and advance them toward precision medicine.  Part of the CPTAC mission is to make data and tools available and accessible to the greater research community to accelerate the discovery process.

Research needs of the new accelerator technologies

International Nuclear Information System (INIS)

Sessler, A.M.

1982-08-01

A review is given of some of the new accelerator technologies with a special eye to the requirements which they generate for research and development. Some remarks are made concerning the organizational needs of accelerator research

The Radiological Research Accelerator Facility

International Nuclear Information System (INIS)

Hall, E.J.

1992-05-01

The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) -- formerly the Radiological Research Laboratory (RRL) -- of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF is available to all potential users on an equal basis, and scientists outside the CRR are encouraged to submit proposals for experiments at RARAF. The operation of the Van de Graaff is supported by the DOE, but the research projects themselves must be supported separately. Experiments performed from May 1991--April 1992 are described

Present state of studies on FFAG accelerator for radiotherapy of cancer in National Institute of Radiological Sciences

International Nuclear Information System (INIS)

Misu, Toshiyuki

2003-01-01

From 2001, developmental contract studies with Ministry of Education, Culture, Sports, Science and Technology for a compact accelerator for heavy ion radiotherapy of cancer started in National Institute of Radiological Sciences (NIRS) with use of fixed field alternating gradient (FFAG) accelerator, which had been developed in High Energy Accelerator Research Organization (KEK). This paper describes the present state of those studies. Described are FFAG accelerator design for repeated acceleration for 200 Hz or more toward the carbon ion at 400 MeV/u with the range of 25 cm in water, FFAG optical systems for these purposes by linear analyses, and the present situation of the design. Technological problems yielded and future study plan are also commented. (N.I.)

Ethical aspect of the clinical research. Informed consent in the clinical research for heavy ion radiotherapy of cancer

International Nuclear Information System (INIS)

Murata, Hajime

2003-01-01

The research center for heavy ion therapy of cancer was decided to be built in 1984 as a part of the national 10-year anticancer campaign, and construction of Heavy Ion Medical Accelerator in Chiba (HIMAC) was completed at the National Institute of Radiological Sciences in 1993. The HIMAC is the first heavy ion accelerator for only medical use in the world, and the clinical research of cancer radiotherapy was begun in 1994 using carbon ion generated by HIMAC. The purposes of the clinical research are to evaluate the safety and usefulness of carbon ion for cancer treatment, and to establish carbon ion therapy as a new and valuable tool for cancer therapy. Therefore, to obtain exact data in ethical aspect as well as scientific aspect of the clinical research, many special committees have been organized like as the committees of protocol planning for each organ, clinical study groups for each organ, evaluating committee of clinical data, and the ethical committee. Each clinical research is performed according to the research protocol of each organ, in which study purpose, rationale, patient condition, end-point of the study, adverse reaction are described. The document of informed consent (IC) contains study purpose, patient condition, method, predicted effect and demerit, protection of privacy, etc.. IC to each patient is done precisely by the doctor, and the freely-given IC of the patient is obtained. After the IC was completed, judgement of propriety for carbon ion therapy is done by the ethical committee for IC of each patient. Since 1994 carbon ion therapy has been performed over 1300 patients with cancer in various organs, and its safety and usefulness for cancer treatment has been clarified gradually. The carbon ion therapy is thought to be a new and promising tool for cancer treatment near future. (authors)

Accelerator and fusion research division

International Nuclear Information System (INIS)

1992-12-01

This report contains brief discussions on research topics in the following area: Heavy-Ion Fusion Accelerator Research; Magnetic Fusion Energy; Advanced Light Source; Center for Beam Physics; Superconducting Magnets; and Bevalac Operations

The Radiological Research Accelerator Facility

International Nuclear Information System (INIS)

Hall, E.J.; Marino, S.A.

1993-05-01

The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) - formerly the Radiological Research Laboratory of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF is available to all potential users on an equal basis and scientists outside the CRR are encouraged to submit proposals for experiments at RARAF. The operation of the Van de Graaff is supported by the DOE, but the research projects themselves must be supported separately. This report provides a listing and brief description of experiments performed at RARAF during the May 1, 1992 through April 30, 1993

Cancer Research

Science.gov (United States)

NCI is the nation's leader in cancer research. Learn more about NCI's cancer research areas, key initiatives, progress made in cancer research, and resources for researchers like research tools, specimens and data.

The future workforce in cancer prevention: advancing discovery, research, and technology.

Science.gov (United States)

Newhauser, Wayne D; Scheurer, Michael E; Faupel-Badger, Jessica M; Clague, Jessica; Weitzel, Jeffrey; Woods, Kendra V

2012-05-01

As part of a 2-day conference on October 15 and 16, 2009, a nine-member task force composed of scientists, clinicians, educators, administrators, and students from across the USA was formed to discuss research, discovery, and technology obstacles to progress in cancer prevention and control, specifically those related to the cancer prevention workforce. This article summarizes the task force's findings on the current state of the cancer prevention workforce in this area and its needs for the future. The task force identified two types of barriers impeding the current cancer prevention workforce in research, discovery, and technology from reaching its fullest potential: (1) limited cross-disciplinary research opportunities with underutilization of some disciplines is hampering discovery and research in cancer prevention, and (2) new research avenues are not being investigated because technology development and implementation are lagging. Examples of impediments and desired outcomes are provided in each of these areas. Recommended solutions to these problems are based on the goals of enhancing the current cancer prevention workforce and accelerating the pace of discovery and clinical translation.

CRISPR/Cas9 for cancer research and therapy.

Science.gov (United States)

Zhan, Tianzuo; Rindtorff, Niklas; Betge, Johannes; Ebert, Matthias P; Boutros, Michael

2018-04-16

CRISPR/Cas9 has become a powerful method for making changes to the genome of many organisms. First discovered in bacteria as part of an adaptive immune system, CRISPR/Cas9 and modified versions have found a widespread use to engineer genomes and to activate or to repress the expression of genes. As such, CRISPR/Cas9 promises to accelerate cancer research by providing an efficient technology to dissect mechanisms of tumorigenesis, identify targets for drug development, and possibly arm cells for cell-based therapies. Here, we review current applications of the CRISPR/Cas9 technology for cancer research and therapy. We describe novel Cas9 variants and how they are used in functional genomics to discover novel cancer-specific vulnerabilities. Furthermore, we highlight the impact of CRISPR/Cas9 in generating organoid and mouse models of cancer. Finally, we provide an overview of the first clinical trials that apply CRISPR/Cas9 as a therapeutic approach against cancer. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

UCLA accelerator research ampersand development. Progress report

International Nuclear Information System (INIS)

1997-01-01

This report discusses work on advanced accelerators and beam dynamics at ANL, BNL, SLAC, UCLA and Pulse Sciences Incorporated. Discussed in this report are the following concepts: Wakefield acceleration studies; plasma lens research; high gradient rf cavities and beam dynamics studies at the Brookhaven accelerator test facility; rf pulse compression development; and buncher systems for high gradient accelerator and relativistic klystron applications

Applied Physics Research at the Idaho Accelerator Center

International Nuclear Information System (INIS)

Date, D. S.; Hunt, A. W.; Chouffani, K.; Wells, D. P.

2011-01-01

The Idaho Accelerator Center, founded in 1996 and based at Idaho State University, supports research, education, and high technology economic development in the United States. The research center currently has eight electron linear accelerators ranging in energy from 6 to 44 MeV with the latter linear accelerator capable of picosecond pulses, a 2 MeV positive-ion Van de Graaff, a 4 MV Nec tandem Pelletron, and a pulsed-power 8 k A, 10 MeV electron induction accelerator. Current research emphases include, accelerator physics research, accelerator based medical isotope production, active interrogation techniques for homeland security and nuclear nonproliferation applications, non destructive testing and materials science studies in support of industry as well as the development of advanced nuclear fuels, pure and applied radio-biology, and medical physics. This talk will highlight three of these areas including the production of the isotopes 99 Tc and 67 Cu for medical diagnostics and therapy, as well as two new technologies currently under development for nuclear safeguards and homeland security - namely laser Compton scattering and the polarized photofission of actinides

The SARAF Project - Soreq Applied Research Accelerator Facility

International Nuclear Information System (INIS)

Nagler, A.; Mardor, I.; Berkovits, D.; Piel, C.

2004-01-01

The relevance of particle accelerators to society, in the use of their primary and secondary beams for the analysis of physical, chemical and biological samples and for modification of properties of materials, is well recognized and documented. Nevertheless, apart of the construction of small accelerators for nuclear research in the 1960's and 70's, Israel has so far neglected this important and growing field. Furthermore, there is an urgent need in Israel for a state of the art research facility to attract and introduce students to current advanced physics techniques and technologies and to train the next generation of experimental scientists in various branches and disciplines. Therefore, Soreq NRC recently initiated the establishment of a new accelerator facility, named SARAF Soreq Applied Research Accelerator Facility. SARAF will be a continuous wave (CW), proton and deuteron RF superconducting linear accelerator with variable energy (5 - 40 MeV) and current (0.04 -2 mA). SARAF is designed to enable hands-on maintenance, which means that its beam loss will be below 10 -5 for the entire accelerator. These specifications will place SARAF in line with the next generation of accelerators world wide. Soreq expects that this fact will attract the Israeli and international research communities to use this facility extensively. Soreq NRC intends to use SARAF for basic, medical and biological research, and non-destructive testing (NDT). Another major activity will be the research and development of radio-isotopes production techniques. Given the availability of high current (up to 2 mA) protons and deuterons, a major activity will be research and development of high power density (up to 80 kW on a few cm 2 ) irradiation targets

Construction of ion accelerator for ion-surface interaction research

International Nuclear Information System (INIS)

Obara, Kenziro; Ohtsuka, Hidewo; Yamada, Rayji; Abe, Tetsuya; Sone, Kazuho

1977-09-01

A Cockcroft-Walton type ion accelerator for ion-surface interaction research was installed at Plasma Engineering Laboratory, Division of Thermonuclear Fusion Research, JAERI, in March 1977. Its maximum accelerating voltage is 400 kV. The accelerator has some outstanding features compared with the conventional type. Described are setup of the accelerator specification of the major components, safety system and performance. (auth.)

International Szent-Györgyi Prize for Progress in Cancer Research: basic and translational research recognition : Mary-Claire King received the 2016 Prize for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer.

Science.gov (United States)

Hartmann, Hali; Zhao, Jie; Ba, Sujuan

2017-11-21

The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that supports innovative cancer research globally with the ultimate goal to cure cancer. The coveted Szent-Györgyi Prize annually honors a scientist whose seminal discovery or body of work has resulted in, or led toward, notable contributions to cancer prevention, diagnosis, or treatment; and the discovery has had a high direct impact of saving people's lives. In addition, the prize promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. In 2016, NFCR's Szent-Györgyi Prize Selection Committee was unanimous in its decision to recognize an icon in human disease genetics, Dr. Mary-Claire King, for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer. Her proof of existence of BRCA1 gene and its location has made genetic screening for breast and ovarian cancers possible, saving lives of many people who are at high risk with inherited BRCA1 mutations.

A New Type of Accelerator for Charged Particle Cancer Therapy

CERN Document Server

Edgecock, Rob

2013-01-01

acceleration of protons and light ions for the treatment of certain cancers. They have unique features as they combine techniques from the existing types of accelerators, cyclotrons and synchrotrons, and hence look to have advantages over both for this application. However, these unique features meant that it was necessary to build one of these accelerators to show that it works and to undertake a detailed conceptual design of a medical machine. Both of these have now been done. This paper will describe the concepts of this type of accelerator, show results from the proof-of-principle machine (EMMA) and described the medical machine (PAMELA).

Heavy-Ion Fusion Accelerator Research, 1991

International Nuclear Information System (INIS)

1992-03-01

This report discusses the following topics: research with multiple- beam experiment MBE-4; induction linac systems experiments; and long- range research and development of heavy-ion fusion accelerators

Accelerator research studies: Progress report, Task B

International Nuclear Information System (INIS)

1985-06-01

The main objectives in Task B of the research program are summarized as follows: (1) studies of the collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (2) studies of ways in which external control may be achieved over the electron beam front in order to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, and (3) study of electron and ion beam generation in a new kind of compact pulsed accelerator in which energy is stored inductively and switched using a plasma focus opening switch. During the past year, substantial progress was made in each of these areas. Our exploratory research on the collective acceleration of laser-produced ions has confirmed the acceleration of C, Al, and Fe ions to peak energies in excess of 10 MeV/amu. In addition, studies of the relation between collective ion acceleration and electron beam propagation in vacuum have shed new light on the experimental processes that lead to energy transfer from electrons to ions. Meanwhile, extensive progress has been made in our attempts to use analytical theory and numerical simulation to model ion acceleration in these systems. Our resultant improved understanding of the processes that limit the peak ion energy has had a profound impact on our plans for further research in this area. Studies of the Compact Pulsed Accelerator have included both ion and electron beam extraction from the device. Its potential to reduce the volume of pulse power sources by an order of magnitude has already been demonstrated, and plans are currently underway to scale the experiment up to voltages in the 1 MV range

Advanced accelerator and mm-wave structure research at LANL

Energy Technology Data Exchange (ETDEWEB)

Simakov, Evgenya Ivanovna [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-06-22

This document outlines acceleration projects and mm-wave structure research performed at LANL. The motivation for PBG research is described first, with reference to couplers for superconducting accelerators and structures for room-temperature accelerators and W-band TWTs. These topics are then taken up in greater detail: PBG structures and the MIT PBG accelerator; SRF PBG cavities at LANL; X-band PBG cavities at LANL; and W-band PBG TWT at LANL. The presentation concludes by describing other advanced accelerator projects: beam shaping with an Emittance Exchanger, diamond field emitter array cathodes, and additive manufacturing of novel accelerator structures.

19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

CERN Multimedia

Anna Pantelia

2013-01-01

19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

Low energy accelerators for research and applications

International Nuclear Information System (INIS)

Bhandari, R.K.

2013-01-01

Charged particle accelerators are instruments for producing a variety of radiations under controlled conditions for basic and applied research as well as applications. They have helped enormously to study the matter, atoms, nuclei, sub-nuclear particles and their constituents, forces involved in the related phenomena etc. No other man-made instrument has been so effective in such studies as the accelerator. The large accelerator constructed so far is the Large Hadron Collider (LHC) housed in a tunnel of 27 km circumference, while a small accelerator can fit inside a room. Small accelerators accelerate charged particles such as electrons, protons, deuterons, alphas and, in general ions to low energy, generally, below several MeV. These particle beams are used for studies in nuclear astrophysics, atomic physics, material science, surface physics, bio sciences etc. They are used for ion beam analysis such as RBS, PIXE, NRA, AMS, CPAA etc. More importantly, the ion beams have important industrial applications like ion implantation, surface modification, isotope production etc. while electron beams are used for material processing, material modification, sterilization, food preservation, non destructive testing etc. In this talk, role of low energy accelerators in research and industry as well as medicine will be discussed. (author)

Accelerator research studies

International Nuclear Information System (INIS)

1993-01-01

The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the second year of a three-year funding cycle. The program consists of the following three tasks: TASK A, ''Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams,'' (P.I., M. Reiser); TASK B, ''Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams,'' (Co-P.I.'s, W.W. Destler, M. Reiser, M.J. Rhee, and C.D. Striffler); TASK C, ''Study of a Gyroklystron High-Power Microwave Source for Linear Colliders,'' (Co-P.I.'s, V.L. Granatstein, W. Lawson, M. Reiser, and C.D. Striffler). In this report we document the progress that has been made during the past year for each of the three tasks

ACCELERATED ONSET OF RETINAL TOXICITY FROM HYDROXYCHLOROQUINE USE WITH CONCOMITANT BREAST CANCER THERAPY.

Science.gov (United States)

Sharma, Aman; Maiz, Alejandra M; Tucker, William R; Cukras, Catherine

2018-05-16

To report a case of accelerated retinal toxicity due to hydroxychloroquine (HCQ) use for treatment of Sjögren syndrome in a patient treated with concomitant chemotherapy for breast cancer. Observational case report. A 56-year-old white woman using 400 mg HCQ (7.1 mg/kg real body weight) daily for a total of 2 years and 10 months for treatment of Sjögren syndrome with concomitant use of docetaxel and cyclophosphamide therapy (21-day cycle, 4 cycles) followed by anastrozole for breast cancer, presented with visual complaints and findings of severe HCQ toxicity. Concomitant breast cancer therapy may have a synergistic effect with HCQ leading to accelerated retinal toxicity. As such potential acceleration is poorly understood, patients on HCQ who are treated with concomitant chemotherapy should be considered for more frequent retinal screenings to maximize safety and preservation of vision.

The History and Role of Accelerators in Radiation Oncology

Science.gov (United States)

Smith, Alfred

2003-04-01

Over one million people are diagnosed with cancer (excluding skin cancer) each year in the United States - about half of those patients will receive radiation as part of their treatment. Radiation Oncology is the field of medicine that specializes in the treatment of cancer with radiation. The evolution of Radiation Oncology, and its success as a cancer treatment modality, has generally paralleled developments in imaging and accelerator technologies. Accelerators, the topic of this paper, have proven to be highly reliable, safe and efficient sources of radiation for cancer treatment. Advances in accelerator technology, especially those that have provided higher energies and dose rates, and more localized (to the tumor volume) dose distributions, have enabled significant improvements in the outcomes of cancer treatments. The use of Cobalt 60 beams has greatly declined in the past decade. Radiation beams used in cancer treatment include x-rays, electrons, protons, negative pions, neutrons, and ions of helium, carbon, neon and silicon. X-rays and electrons, produced by linear electron accelerators, have been the most widely used. The history of medical accelerators can be traced from Roentgen's discovery of x-rays in 1895. The evolution of medical electron accelerators will be discussed and the use of x-ray tubes, electrostatic accelerators, betatrons, and linear accelerators will be described. Heavy particle cancer treatments began in 1955 using proton beams from the Berkeley 184-inch cyclotron. Accelerators that have been used for heavy particle therapy include the Berkeley Bevalac, Los Alamos Pion Facility, Fermi Laboratory, and various research and medical cyclotrons and synchrotrons. Heavy particle accelerators and their application for cancer treatment will be discussed.

Light Ion Biomedical Research Accelerator LIBRA

International Nuclear Information System (INIS)

Gough, R.A.

1987-01-01

LIBRA is a concept to place a light-ion, charged-particle facility in a hospital environment, and to dedicate it to applications in biology and medicine. There are two aspects of the program envisaged for LIBRA: a basic research effort coupled with a program in clinical applications of accelerated charged particles. The operational environment to be provided for LIBRA is one in which both of these components can coexist and flourish, and one that will promote the transfer of technology and knowledge from one to the other. In order to further investigate the prospects for a Light Ion Biomedical Research Accelerator (LIBRA), discussions are underway with the Merritt Peralta Medical Center MPMC) in Oakland CA, and the University of California at San Francisco (UCSF). In this paper, a brief discussion of the technical requirements for such a facility is given, together with an outline of the accelerator technology required. While still in a preliminary stage, it is possible nevertheless to develop an adequate working description of the type, size, performance and cost of the accelerator facilities required to meet the preliminary goals for LIBRA

Advanced Accelerator Applications in Medicine

International Nuclear Information System (INIS)

Rimjiaem, Sakhorn

2015-01-01

besides the original purpose on development of particle acceleratora as research tools in nuclear and high-energy physics, there are large variety of accelerators used in various fileds from fundamental research to industrial usesand applications chemistry, biology and medicine. Pratical accelators used in various field of medical applications since serveral decades. Even through, a large fraction of applications is emphasized on cancer therappy, the number of accelerators used in midicine for other diagnostics and treatments has increased steady over the years. Several types of accelerated particles are used including electron, proton, neutron and ions. Presently, relativistic electron beams and radiation from linear accelerators (linas) are widely used. A combination of positron emission tomography (PRT) and radiotherapy is an example of excellent invention early detection and treat of cancer tumors. The most developments for proton and heavy ion therapy as well as a modern boron neutron capture therapy (BNCT) are also great incoming effective systems. This talk will focus on developments of the accelrator systems as well as overview on biophysical properties and medical aspects of the diacnostics and treatments.

Translating research into practice: the role of provider-based research networks in the diffusion of an evidence-based colon cancer treatment innovation.

Science.gov (United States)

Carpenter, William R; Meyer, Anne-Marie; Wu, Yang; Qaqish, Bahjat; Sanoff, Hanna K; Goldberg, Richard M; Weiner, Bryan J

2012-08-01

Provider-based research networks (PBRNs)--collaborative research partnerships between academic centers and community-based practitioners--are a promising model for accelerating the translation of research into practice; however, empirical evidence of accelerated translation is limited. Oxaliplatin in adjuvant combination chemotherapy is an innovation with clinical trial-proven survival benefit compared with prior therapies. The goal of this study is to examine the diffusion of oxaliplatin into community practice, and whether affiliation with the National Cancer Institute's (NCI's) Community Clinical Oncology Program (CCOP)--a nationwide cancer-focused PBRN--is associated with accelerated innovation adoption. This retrospective observational study used linked Surveillance, Epidemiology, and End Results-Medicare and NCI CCOP data to examine Medicare participants with stage III colon cancer initiating treatment in 2003 through 2006, the years surrounding oxaliplatin's Food and Drug Administration approval. A fixed-effects analysis examined chemotherapy use among patients treated outside academic centers at CCOP-affiliated practices compared with non-CCOP practices. Two-group modeling controlled for multiple levels of clustering, year of chemotherapy initiation, tumor characteristics, patient age, race, comorbidity, Medicaid dual-eligibility status, and education. Of 4055 community patients, 35% received 5-fluoruracil, 20% received oxaliplatin, 7% received another chemotherapy, and 38% received no chemotherapy. Twenty-five percent of CCOP patients received oxaliplatin, compared with 19% of non-CCOP patients. In multivariable analysis, CCOP exposure was associated with higher odds of receiving guideline-concordant treatment in general, and oxaliplatin specifically. These findings contribute to a growing set of evidence linking PBRNs with a greater probability of receiving treatment innovations and high-quality cancer care, with implications for clinical and research

Accelerator and Fusion Research Division 1989 summary of activities

International Nuclear Information System (INIS)

1990-06-01

This report discusses the research being conducted at Lawrence Berkeley Laboratory's Accelerator and Fusion Research Division. The main topics covered are: heavy-ion fusion accelerator research; magnetic fusion energy; advanced light source; center for x-ray optics; exploratory studies; high-energy physics technology; and bevalac operations

RF-Based Accelerators for HEDP Research

CERN Document Server

Staples, John W; Keller, Roderich; Ostroumov, Peter; Sessler, Andrew M

2005-01-01

Accelerator-driven High-Energy Density Physics experiments require typically 1 nanosecond, 1 microcoulomb pulses of mass 20 ions accelerated to several MeV to produce eV-level excitations in thin targets, the "warm dense matter" regime. Traditionally the province of induction linacs, RF-based acceleration may be a viable alternative with recent breakthroughs in accelerating structures and high-field superconducting solenoids. A reference design for an RF-based accelerator for HEDP research is presented using 15 T solenoids and multiple-gap RF structures configured with either multiple parallel beams (combined at the target) or a single beam and a small stacking ring that accumulates 1 microcoulomb of charge. In either case, the beam is ballistically compressed with an induction linac core providing the necessary energy sweep and injected into a plasma-neutralized drift compression channel resulting in a 1 mm radius beam spot 1 nanosecond long at a thin foil or low-density target.

Accelerator and Fusion Research Division 1989 summary of activities

Energy Technology Data Exchange (ETDEWEB)

1990-06-01

This report discusses the research being conducted at Lawrence Berkeley Laboratory's Accelerator and Fusion Research Division. The main topics covered are: heavy-ion fusion accelerator research; magnetic fusion energy; advanced light source; center for x-ray optics; exploratory studies; high-energy physics technology; and bevalac operations.

Accelerator and Fusion Research Division: Summary of activities, 1986

International Nuclear Information System (INIS)

1987-01-01

This report contains a summary of activities at the Lawrence Berkeley Laboratory's Accelerator and Fusion Research Division for the year 1986. Topics and facilities investigated in individual papers are: 1-2 GeV Synchrotron Radiation Source, the Center for X-Ray Optics, Accelerator Operations, High-Energy Physics Technology, Heavy-Ion Fusion Accelerator Research and Magnetic Fusion Energy. Six individual papers have been indexed separately

KEK (High Energy Accelerator Research Organization) annual report, 2005

International Nuclear Information System (INIS)

2006-01-01

This report summarizes research activities of KEK (High Energy Accelerator Research Organization) in the fiscal year 2005. Two years have passed since the KEK was reorganized as an inter-university research institute corporation, and KEK continue to facilitate a wide range of research programs based on high-energy accelerators for users from universities. KEK consists of two research institutes, the Institute of Particle and Nuclear Studies (IPNS) and the Institute of Materials Science (IMSS); and two laboratories, the Accelerator Laboratory and the Applied Research Laboratory. KEK has been operating four major accelerator facilities in Tsukuba: the 12 GeV Proton Synchrotron (PS), the KEK B-factory (KEKB), the Photon Factory (PF), and the Electron/Positron Injector Linac. We are now engaged in the construction of the Japan Proton Accelerator Research Complex (J-PARC) in Tokai in cooperation with the Japan Atomic Energy Agency (JAEA). The J-PARC Center was established in February 2006 to take full responsibility for the operation of J-PARC. With the progress of construction, the PS ceased operation at the end of March 2006 after a history of 26 years. The task of KEK is to play a key role in the fields of elementary particle, nuclei, materials and life science as one of leading research facilities of the world. The fiscal year 2005 activities of both KEK employees and visiting researchers yielded excellent outcomes in these research fields. (J.P.N.)

Medical uses of accelerators

International Nuclear Information System (INIS)

Bradbury, J.N.

1981-01-01

A variety of particle accelerators have either potential or already demonstrated uses in connection with medically-related research, diagnosis, and treatment. For cancer radiotherapy, nuclear particles including protons, neutrons, heavy ions, and negative pi mesons have advantages compared to conventional radiations in terms of dose localization and/or biological effectiveness. Clinical evaluations of these particles are underway at a number of institutions. Accelerator-produced radionuclides are in widespread use for research and routine diagnostic purposes. Elemental analysis techniques with charged particles and neutrons are being applied to bone, blood, and other tissues. Finally, low-dose medical imaging can be accomplished with accelerated protons and heavy ions. The status and future of these programs are discussed

Accelerator research studies. Progress report

International Nuclear Information System (INIS)

1984-06-01

Progress is reported in both experimental studies as well as theoretical understanding of the beam transport problem. Major highlights are: (a) the completion of the first channel section with 12 periods and two matching solenoids, (b) measurements of beam transmission and emittance in this 12-lens channel, (c) extensive analytical and numerical studies of the beam transport problem in collaboration with GSI (W. Germany), (d) detailed measurements and calculations of beam propagation through one lens with spherical aberration and space charge, and (e) completion of the emittance grids at the Rutherford-Appleton Laboratory. Our main objectives in Task B of our research program are: (a) study of collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (b) external control of the IREB beam front by a slow-wave structure to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, (c) study of ion and electron acceleration and other applications of a plasma focus device, and (d) theoretical studies in support of (a) and (b). Our research in these areas has been oriented towards obtaining an improved understanding of the physical processes at work in these experiments and, subsequently, achieving improved performance for specific potential applications

Accelerator Center for Energy Research (ACER)

Data.gov (United States)

Federal Laboratory Consortium — The Accelerator Center for Energy Research (ACER) exploits radiation chemistry techniques to study chemical reactions (and other phenomena) by subjecting samples to...

A study of light ion accelerators for cancer treatment

International Nuclear Information System (INIS)

Prelec, K.

1997-07-01

This review addresses several issues, such as possible advantages of light ion therapy compared to protons and conventional radiation, the complexity of such a system and its possible adaptation to a hospital environment, and the question of cost-effectiveness compared to other modalities for cancer treatment or to other life saving procedures. Characteristics and effects of different types of radiation on cells and organisms will be briefly described; this will include conventional radiation, protons and light ions. The status of proton and light ion cancer therapy will then be described, with more emphasis on the latter; on the basis of existing experience the criteria for the use of light ions will be listed and areas of possible medical applications suggested. Requirements and parameters of ion beams for cancer treatment will then be defined, including ion species, energy and intensity, as well as parameters of the beam when delivered to the target (scanning, time structure, energy spread). Possible accelerator designs for light ions will be considered, including linear accelerators, cyclotrons and synchrotrons and their basic features given; this will be followed by a review of existing and planned facilities for light ions. On the basis of these considerations a tentative design for a dedicated light ion facility will be suggested, a facility that would be hospital based, satisfying the clinical requirements, simple to operate and reliable, concluding with its cost-effectiveness in comparison with other modalities for treatment of cancer

Concept of an accelerator-driven subcritical research reactor within the TESLA accelerator installation

International Nuclear Information System (INIS)

Pesic, Milan; Neskovic, Nebojsa

2006-01-01

Study of a small accelerator-driven subcritical research reactor in the Vinca Institute of Nuclear Sciences was initiated in 1999. The idea was to extract a beam of medium-energy protons or deuterons from the TESLA accelerator installation, and to transport and inject it into the reactor. The reactor core was to be composed of the highly enriched uranium fuel elements. The reactor was designated as ADSRR-H. Since the use of this type of fuel elements was not recommended any more, the study of a small accelerator-driven subcritical research reactor employing the low-enriched uranium fuel elements began in 2004. The reactor was designated as ADSRR-L. We compare here the results of the initial computer simulations of ADSRR-H and ADSRR-L. The results have confirmed that our concept could be the basis for designing and construction of a low neutron flux model of the proposed accelerator-driven subcritical power reactor to be moderated and cooled by lead. Our objective is to study the physics and technologies necessary to design and construct ADSRR-L. The reactor would be used for development of nuclear techniques and technologies, and for basic and applied research in neutron physics, metrology, radiation protection and radiobiology

Accelerator and Fusion Research Division: 1987 summary of activities

International Nuclear Information System (INIS)

1988-04-01

An overview of the design and the initial studies for the Advanced Light Source is given. The research efforts for the Center for X-Ray Optics include x-ray imaging, multilayer mirror technology, x-ray sources and detectors, spectroscopy and scattering, and synchrotron radiation projects. The Accelerator Operations highlights include the research by users in nuclear physics, biology and medicine. The upgrade of the Bevalac is also discussed. The High Energy Physics Technology review includes the development of superconducting magnets and superconducting cables. A review of the Heavy-Ion Fusion Accelerator Research is also presented. The Magnetic Fusion Energy research included the development of ion sources, accelerators for negative ions, diagnostics, and theoretical plasma physics

Accelerator and Fusion Research Division: 1987 summary of activities

Energy Technology Data Exchange (ETDEWEB)

1988-04-01

An overview of the design and the initial studies for the Advanced Light Source is given. The research efforts for the Center for X-Ray Optics include x-ray imaging, multilayer mirror technology, x-ray sources and detectors, spectroscopy and scattering, and synchrotron radiation projects. The Accelerator Operations highlights include the research by users in nuclear physics, biology and medicine. The upgrade of the Bevalac is also discussed. The High Energy Physics Technology review includes the development of superconducting magnets and superconducting cables. A review of the Heavy-Ion Fusion Accelerator Research is also presented. The Magnetic Fusion Energy research included the development of ion sources, accelerators for negative ions, diagnostics, and theoretical plasma physics. (WRF)

EuCARD2: enhanced accelerator research and development in Europe

Science.gov (United States)

Romaniuk, Ryszard S.

2013-10-01

Accelerator science and technology is one of a key enablers of the developments in the particle physic, photon physics and also applications in medicine and industry. EuCARD2 is an European research project which will be realized during 2013-2017 inside the EC FP7 framework. The project concerns the development and coordination of European Accelerator Research and Development. The project is particularly important, to a number of domestic laboratories, due to some plans to build large accelerator infrastructure in Poland. Large accelerator infrastructure of fundamental and applied research character stimulates around it the development and industrial applications as well as biomedical of advanced accelerators, material research and engineering, cryo-technology, mechatronics, robotics, and in particular electronics - like networked measurement and control systems, sensors, computer systems, automation and control systems. The paper presents a digest of the European project EuCARD2 which is Enhanced European Coordination for Accelerator Research and Development. The paper presents a digest of the research results and assumptions in the domain of accelerator science and technology in Europe, shown during the final fourth annual meeting of the EuCARD - European Coordination of Accelerator R&D, and the kick-off meeting of the EuCARD2. There are debated a few basic groups of accelerator systems components like: measurement - control networks of large geometrical extent, multichannel systems for large amounts of metrological data acquisition, precision photonic networks of reference time, frequency and phase distribution, high field magnets, superconducting cavities, novel beam collimators, etc. The paper bases on the following materials: Internet and Intranet documents combined with EuCARD2, Description of Work FP7 EuCARD-2 DoW-312453, 2013-02-13, and discussions and preparatory materials worked on by Eucard-2 initiators.

New heavy-ion-fusion accelerator research program

International Nuclear Information System (INIS)

Herrmannsfeldt, W.B.

1983-05-01

This paper will briefly summarize the concepts of Heavy Ion Fusion (HIF), especially those aspects that are important to its potential for generating electrical power. It will also note highlights of the various HIF programs throughout the world. Especially significant is that the US Department of Energy (DOE) plans a program, beginning in 1984, aimed at determining the feasibility of using heavy ion accelerators as drivers for Inertial Confinement Fusion (ICF). The new program concentrates on the aspects of accelerator design that are important to ICF, and for this reason is called HIF Accelerator Research

Advanced accelerator research and development

International Nuclear Information System (INIS)

Anon.

1974-01-01

Research and development on the Positron-Electron Project (PEP), the electron rings, the superconducting accelerator (ESCAR), and the superconductivity program are reported. Efforts relating to the proposed PEP include work on: (1) the injection system; (2) the rf system; (3) the main-ring bend magnets; (4) the magnet power supplies and controls; (5) alignment; (6) radiation and shielding; (7) the vacuum system; and (8) conventional facilities (utilities, etc.). Experimental and theoretical work continued on the development of suitably intense electron rings as vehicles for the collective acceleration of ions. The most difficult problem was found to be the longitudinal (negative mass) instability. Design work was begun for ESCAR (Experimental Superconducting Accelerating Ring), a small proton synchrotron and storage ring using superconducting magnets, which should aid in the design of future large superconducting facilities. Magnet development was largely directed toward the detailed design of the dipole units. A superconducting beam transport line was installed at the Bevatron. (PMA)

THE CARE PROJECT - Coordinated Accelerator Research in Europe

CERN Multimedia

2003-01-01

A one-day presentation of the project will take place on Monday February 10th in the CERN Council Chamber. The meeting will start a 9am and is expected to end at 4:30pm. The meeting, which is open to the whole community, will present an initiative on accelerator R&D in Europe, supported by ECFA, with the aim to bid for European Union support through the Framework 6 scheme. This initiative is coordinated by a steering group (ESGARD - European Steering Group on Accelerator Research and Development), which has been set up to coordinate European efforts on accelerator R&D and the submission of such bids. The initial bids have to be submitted by April 15th. All those interested in accelerator R&D are welcome to attend. Presentation of the CARE project (Coordinated Accelerator Research in Europe) to be submitted within FP6 February 10th, at CERN in the council room Agenda Chair : C. Wyss 9:00 General presentation of FP6 and introduction of IA proposal (R. Aleksan) 9:45 Networking activities on e ...

UCLA accelerator research and development

International Nuclear Information System (INIS)

Cline, D.B.

1992-01-01

This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the φ Factory

The Light Ion Biomedical Research Accelerator (LIBRA)

International Nuclear Information System (INIS)

Gough, R.A.

1987-03-01

LIBRA is a concept to place a light-ion, charged-particle facility in a hospital environment, and to dedicate it to applications in biology and medicine. There are two aspects of the program envisaged for LIBRA: a basic research effort coupled with a program in clinical applications of accelerated charged particles. The operational environment to be provided for LIBRA is one in which both of these components can coexist and flourish, and one that will promote the transfer of technology and knowledge from one to the other. In order to further investigate the prospects for a Light Ion Biomedical Research Accelerator (LIBRA), discussions are underway with the Merritt Peralta Medical Center (MPMC) in Oakland, California, and the University of California at San Francisco (UCSF). In this paper, a brief discussion of the technical requirements for such a facility is given, together with an outline of the accelerator technology required. While still in a preliminary stage, it is possible nevertheless to develop an adequate working description of the type, size, performance and cost of the accelerator facilities required to meet the preliminary goals for LIBRA

Accelerating complex for basic researches in the nuclear physics

NARCIS (Netherlands)

Dovbnya, A.N.; Guk, I.S.; Kononenko, S.G.; Peev, F.A.; Tarasenko, A.S.; Botman, J.I.M.

2009-01-01

In 2003 in NSC KIPT was begun the work on development the project of accelerator, base facility IHEPNP NSC KIPT electron recirculator SALO. The accelerator will be disposed in target hall of accelerator LU 2000 complex. It is projected first of all as facility for basic researches in the field of

Accelerator-driven neutron sources for materials research

International Nuclear Information System (INIS)

Jameson, R.A.

1990-01-01

Particle accelerators are important tools for materials research and production. Advances in high-intensity linear accelerator technology make it possible to consider enhanced neutron sources for fusion material studies or as a source of spallation neutrons. Energy variability, uniformity of target dose distribution, target bombardment from multiple directions, time-scheduled dose patterns, and other features can be provided, opening new experimental opportunities. New designs have also been used to ensure hands-on maintenance on the accelerator in these factory-type facilities. Designs suitable for proposals such as the Japanese Energy-Selective Intense Neutron Source, and the international Fusion Materials Irradiation Facility are discussed

Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research.

Science.gov (United States)

Scully, Peter; Zhao, Jie; Ba, Sujuan

2016-02-03

The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR)--a leading cancer research charitable organization in the United States that is committed to supporting scientific research and public education relating to the prevention, early diagnosis, better treatments, and ultimately, a cure for cancer. Each year, the Szent-Györgyi Prize honors an outstanding researcher, nominated by colleagues or peers, who has contributed outstanding, significant research to the fight against cancer, and whose accomplishments have helped improve treatment options for cancer patients. The Prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the pioneering work led by the 2015 Prize winner, Dr. Frederick Alt. Dr. Alt's work in the area of cancer genetics over four decades has helped to shape the very roots of modern cancer research. His work continues to profoundly impact the approaches that doctors around the globe use to diagnose and treat cancer. In particular, his seminal discoveries of gene amplification and his pioneering work on molecular mechanisms of DNA damage repair have helped to usher in the era of genetically targeted therapy and personalized medicine.

Current cancer research. Reports from the German Cancer Research Center 1998

International Nuclear Information System (INIS)

1998-01-01

Topics from the Contents: The Fight against Cancer in Germany - A Critical Review. Conditions and Structures in Research. Familial Breast Cancer - A Critical Assessment. Research without Animal Experiments. Cancer Prevention. New Approaches for Tumor Therapy. Genes, Chromosomes and Cancer. Therapy of Brain Tumors with Laser Neurosurgery. The Genome Project. (orig.) [de

The Radiological Research Accelerator Facility:

International Nuclear Information System (INIS)

Hall, E.J.; Goldhagen, P.

1988-07-01

The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generated a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Radiological Research Laboratory (RRL) of Columbia University, and its operation is supported as a National Facility by the U.S. Department of Energy. As such, RARAF is available to all potential users on an equal basis, and scientists outside the RRL are encouraged to submit proposals for experiments at RARAF. Facilities and services are provided to users, but the research projects themselves must be supported separately. RARAF was located at BNL from 1967 until 1980, when it was dismantled and moved to the Nevis Laboratories of Columbia University, where it was then reassembled and put back into operation. Data obtained from experiment using RARAF have been of pragmatic value to radiation protection and to neutron therapy. At a more fundamental level, the research at RARAF has provided insight into the biological action of radiation and especially its relation to energy distribution in the cell. High-LET radiations are an agent of special importance because they can cause measurable cellular effects by single particles, eliminating some of the complexities of multievent action and more clearly disclosing basic features. This applies particularly to radiation carcinogenesis. Facilities are available at RARAF for exposing objects to different radiations having a wide range of linear energy transfers (LETs)

NIH/NSF accelerate biomedical research innovations

Science.gov (United States)

A collaboration between the National Science Foundation and the National Institutes of Health will give NIH-funded researchers training to help them evaluate their scientific discoveries for commercial potential, with the aim of accelerating biomedical in

Accelerators for condensed matter research

International Nuclear Information System (INIS)

Williams, P.R.

1990-01-01

The requirement for high energy, high luminosity beams has stimulated the science and engineering of accelerators to a point where they open up opportunities for new areas of scientific application to benefit from the advances driven by particle physics. One area of great importance is the use of electron or positron storage rings as a source of intense VUV or X-ray synchrotron radiation. An accelerator application that has grown in prominence over the last 10 years has been spallation neutron sources. Neutrons offer an advantage over X-rays as a condensed matter probe because the neutron energy is usually of the same order as the room temperature thermal energy fluctuations in the sample being studied. Another area in which accelerators are playing an increasingly important role in condensed matter research concerns the use of Mu mesons, Muons, as a probe. This paper also presents a description of the ISIS Spallation Neutron Source. The design and status of the facility are described, and examples are given of its application to the study of condensed matter. (N.K.)

The Design of HVAC System in the Conventional Facility of Proton Accelerator Research Center

International Nuclear Information System (INIS)

Jeon, G. P.; Kim, J. Y.; Choi, B. H.

2007-01-01

The HVAC systems for conventional facility of Proton Accelerator Research Center consist of 3 systems : accelerator building HVAC system, beam application building HVAC system and miscellaneous HVAC system. We designed accelerator building HVAC system and beam application research area HVAC system in the conventional facilities of Proton Accelerator research center. Accelerator building HVAC system is divided into accelerator tunnel area, klystron area, klystron gallery area, accelerator assembly area. Also, Beam application research area HVAC system is divided into those of beam experimental hall, accelerator control area, beam application research area and Ion beam application building. In this paper, We described system design requirements and explained system configuration for each systems. We presented operation scenario of HVAC system in the Conventional Facility of Proton Accelerator Research Center

Accelerator mass spectrometry researches at NIES-TERRA

International Nuclear Information System (INIS)

Shibata, Yasuyuki; Yoneda, Minoru; Tanaka, Atsushi; Uehiro, Takashi; Morita, Masatoshi; Uchida, Masao; Yoshinaga, Jun

2003-01-01

In the AMS facility at the National Institute for Environmental Studies (NIES-TERRA; Tandem accelerator for Environmental Research and Radiocarbon Analysis), several research programs have been proceeded, including a program, called GC-AMS, for the compound-specific 14 C analysis in environmental samples

Geospatial cryptography: enabling researchers to access private, spatially referenced, human subjects data for cancer control and prevention.

Science.gov (United States)

Jacquez, Geoffrey M; Essex, Aleksander; Curtis, Andrew; Kohler, Betsy; Sherman, Recinda; Emam, Khaled El; Shi, Chen; Kaufmann, Andy; Beale, Linda; Cusick, Thomas; Goldberg, Daniel; Goovaerts, Pierre

2017-07-01

As the volume, accuracy and precision of digital geographic information have increased, concerns regarding individual privacy and confidentiality have come to the forefront. Not only do these challenge a basic tenet underlying the advancement of science by posing substantial obstacles to the sharing of data to validate research results, but they are obstacles to conducting certain research projects in the first place. Geospatial cryptography involves the specification, design, implementation and application of cryptographic techniques to address privacy, confidentiality and security concerns for geographically referenced data. This article defines geospatial cryptography and demonstrates its application in cancer control and surveillance. Four use cases are considered: (1) national-level de-duplication among state or province-based cancer registries; (2) sharing of confidential data across cancer registries to support case aggregation across administrative geographies; (3) secure data linkage; and (4) cancer cluster investigation and surveillance. A secure multi-party system for geospatial cryptography is developed. Solutions under geospatial cryptography are presented and computation time is calculated. As services provided by cancer registries to the research community, de-duplication, case aggregation across administrative geographies and secure data linkage are often time-consuming and in some instances precluded by confidentiality and security concerns. Geospatial cryptography provides secure solutions that hold significant promise for addressing these concerns and for accelerating the pace of research with human subjects data residing in our nation's cancer registries. Pursuit of the research directions posed herein conceivably would lead to a geospatially encrypted geographic information system (GEGIS) designed specifically to promote the sharing and spatial analysis of confidential data. Geospatial cryptography holds substantial promise for accelerating the

Essay: Robert H. Siemann As Leader of the Advanced Accelerator Research Department

Energy Technology Data Exchange (ETDEWEB)

Colby, Eric R.; Hogan, Mark J.; /SLAC

2011-11-14

Robert H. Siemann originally conceived of the Advanced Accelerator Research Department (AARD) as an academic, experimental group dedicated to probing the technical limitations of accelerators while providing excellent educational opportunities for young scientists. The early years of the Accelerator Research Department B, as it was then known, were dedicated to a wealth of mostly student-led experiments to examine the promise of advanced accelerator techniques. High-gradient techniques including millimeter-wave rf acceleration, beam-driven plasma acceleration, and direct laser acceleration were pursued, including tests of materials under rf pulsed heating and short-pulse laser radiation, to establish the ultimate limitations on gradient. As the department and program grew, so did the motivation to found an accelerator research center that brought experimentalists together in a test facility environment to conduct a broad range of experiments. The Final Focus Test Beam and later the Next Linear Collider Test Accelerator provided unique experimental facilities for AARD staff and collaborators to carry out advanced accelerator experiments. Throughout the evolution of this dynamic program, Bob maintained a department atmosphere and culture more reminiscent of a university research group than a national laboratory department. His exceptional ability to balance multiple roles as scientist, professor, and administrator enabled the creation and preservation of an environment that fostered technical innovation and scholarship.

Essay: Robert H. Siemann As Leader of the Advanced Accelerator Research Department

International Nuclear Information System (INIS)

Colby, Eric R.; Hogan, Mark J.

2008-01-01

Robert H. Siemann originally conceived of the Advanced Accelerator Research Department (AARD) as an academic, experimental group dedicated to probing the technical limitations of accelerators while providing excellent educational opportunities for young scientists. The early years of the Accelerator Research Department B, as it was then known, were dedicated to a wealth of mostly student-led experiments to examine the promise of advanced accelerator techniques. High-gradient techniques including millimeter-wave rf acceleration, beam-driven plasma acceleration, and direct laser acceleration were pursued, including tests of materials under rf pulsed heating and short-pulse laser radiation, to establish the ultimate limitations on gradient. As the department and program grew, so did the motivation to found an accelerator research center that brought experimentalists together in a test facility environment to conduct a broad range of experiments. The Final Focus Test Beam and later the Next Linear Collider Test Accelerator provided unique experimental facilities for AARD staff and collaborators to carry out advanced accelerator experiments. Throughout the evolution of this dynamic program, Bob maintained a department atmosphere and culture more reminiscent of a university research group than a national laboratory department. His exceptional ability to balance multiple roles as scientist, professor, and administrator enabled the creation and preservation of an environment that fostered technical innovation and scholarship.

Accelerated Deformable Registration of Repetitive MRI during Radiotherapy in Cervical Cancer

DEFF Research Database (Denmark)

Noe, Karsten Østergaard; Tanderup, Kari; Kiritsis, Christian

2006-01-01

Tumour regression and organ deformations during radiotherapy (RT) of cervical cancer represent major challenges regarding accurate conformation and calculation of dose when using image-guided adaptive radiotherapy. Deformable registration algorithms are able to handle organ deformations, which can...... be useful with advanced tools such as auto segmentation of organs and dynamic adaptation of radiotherapy. The aim of this study was to accelerate and validate deformable registration in MRI-based image-guided radiotherapy of cervical cancer.    ...

Types of Cancer Research

Science.gov (United States)

An infographic from the National Cancer Institute (NCI) describing the four broad categories of cancer research: basic research, clinical research, population-based research, and translational research.

Accelerators for Medicine

CERN Multimedia

CERN. Geneva

2018-01-01

This lecture will review the different applications of particle accelerators to the medical field, from cancer treatment with beams of accelerator-produced particles (photons, electrons, protons, ions and neutrons) to the generation of radioactive isotopes used in medical diagnostics, in cancer therapy and in the new domain of theragnostics. For each application will be outlined the state of the art, the potential, and the accelerator challenges to be faced to meet the increasing demand for therapeutic procedures based on accelerators.

Accelerator Fusion Research Division 1991 summary of activities

Energy Technology Data Exchange (ETDEWEB)

Berkner, Klaus H.

1991-12-01

This report discusses research projects in the following areas: Heavy-ion fusion accelerator research; magnetic fusion energy; advanced light source; center for x-ray optics; exploratory studies; superconducting magnets; and bevalac operations.

Accelerator & Fusion Research Division 1991 summary of activities

Energy Technology Data Exchange (ETDEWEB)

1991-12-01

This report discusses research projects in the following areas: Heavy-ion fusion accelerator research; magnetic fusion energy; advanced light source; center for x-ray optics; exploratory studies; superconducting magnets; and bevalac operations.

Research on high beam-current accelerators

International Nuclear Information System (INIS)

Keefe, D.

1981-01-01

In this review of research being undertaken at present in the US on accelerating devices and concepts of a novel nature, both non-collective systems, including high-current rf linacs and a variety of induction linacs, and also collective systems are considered. (U.K.)

Application of accelerator in the medical aspects

International Nuclear Information System (INIS)

Shi Lisheng; Wang Bairong; Yang Zhongping

2014-01-01

In recent years, the human life span compared with before there is an obvious increase in. With the extension of life, cancer incidence is increasing, at the same time, the diagnosis and treatment of cancer has been the development of. Based on the review of the past and present situation of diagnosis and treatment of cancer, the accelerator and the future to introduce, divided into the accelerator treatment, cancer diagnosis, accelerator accelerator with radioactive isotopes, medical accelerator conditions and medical accelerator built five content. (authors)

Accelerator and Fusion Research Division. Annual report, October 1977--September 1978

Energy Technology Data Exchange (ETDEWEB)

1979-04-01

Research is reported for the combined groups consisting of the Accelerator Division and the Magnetic Fusion Energy Group. Major topics reported include accelerator operations, magnetic fusion energy, and advanced accelerator development. (GHT)

Cancer Research UK | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Cancer Research UK. Cancer Research UK. https://www.cancerresearchuk.org/. The Economics of Tobacco Control Research Initiative. The Economics of Tobacco Control Research Initiative funds innovative fiscal policy research supporting tobacco control in low and middle-income countries. View more. The Economics ...

Accelerator & Fusion Research Division: 1993 Summary of activities

Energy Technology Data Exchange (ETDEWEB)

Chew, J.

1994-04-01

The Accelerator and Fusion Research Division (AFRD) is not only one of the largest scientific divisions at LBL, but also the one of the most diverse. Major efforts include: (1) investigations in both inertial and magnetic fusion energy; (2) operation of the Advanced Light Source, a state-of-the-art synchrotron radiation facility; (3) exploratory investigations of novel radiation sources and colliders; (4) research and development in superconducting magnets for accelerators and other scientific and industrial applications; and (5) ion beam technology development for nuclear physics and for industrial and biomedical applications. Each of these topics is discussed in detail in this book.

Teaching and Research with Accelerators at Tarleton State University

International Nuclear Information System (INIS)

Marble, Daniel K.

2009-01-01

Tarleton State University students began performing both research and laboratory experiments using accelerators in 1998 through visitation programs at the University of North Texas, US Army Research Laboratory, and the Naval Surface Warfare Center at Carderock. In 2003, Tarleton outfitted its new science building with a 1 MV pelletron that was donated by the California Institution of Technology. The accelerator has been upgraded and supports a wide range of classes for both the Physics program and the ABET accredited Engineering Physics program as well as supplying undergraduate research opportunities on campus. A discussion of various laboratory activities and research projects performed by Tarleton students will be presented.

Radiological Research Accelerator Facility. Progress report, April 1-November 30, 1986

International Nuclear Information System (INIS)

1986-07-01

The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology and radiological physics. The experiments run at RARAF are described, and center on neutron dosimetry, mutagenesis, and neutron-induced oncogenic transformations as well as survival of exposed cells. Accelerator utilization, operation, and development of facilities are reviewed

Research project on accelerator-driven subcritical system using FFAG accelerator and Kyoto University critical assembly

International Nuclear Information System (INIS)

Mishima, Kaichiro; Unesaki, Hironobu; Misawa, Tsuyoshi; Tanigaki, Minoru; Mori, Yoshiharu; Shiroya, Seiji; Inoue, Makoto; Ishi, Y.; Fukumoto, Shintaro

2005-01-01

The KART (Kumatori Accelerator-driven Reactor Test facility) project started in Research Reactor Institute, Kyoto University in fiscal year 2002 with the grant by the Japanese Ministry of Education, Culture, Sports, Science and Technology. The purpose of this research project is to demonstrate the basis feasibility of accelerator driven system (ADS), studying the effect of incident neutron energy on the effective multiplication factor in a subcritical nuclear fuel system. For this purpose, a variable-energy FFAG (Fixed Field Alternating Gradient) accelerator complex is being constructed to be coupled with the Kyoto University Critical Assembly (KUCA). The FFAG proton accelerator complex consists of ion-beta, booster and main rings. This system aims to attain 1 μA proton beam with energy range from 20 to 150 MeV with a repetition rate of 120 Hz. The first beam from the FFAG complex is expected to be available by the end of FY 2005, and the experiment on ADS with KUCA and the FFAG complex (FFAG-KUCA experiment) will start in FY 2006. Before the FFAG-KUCA experiment starts, preliminary experiments with 14 MeV neutrons are currently being performed using a Cockcroft-Walton type accelerator coupled with the KUCA. Experimental data are analyzed using continuous energy Monte-Carlo codes MVP, MCNP and MNCP-X. (author)

Current cancer research 1998

Energy Technology Data Exchange (ETDEWEB)

Stamatiadis-Smidt, H. [ed.

1998-12-31

Topics from the Contents: The Fight against Cancer in Germany - A Critical Review. Conditions and Structures in Research. Familial Breast Cancer - A Critical Assessment. Research without Animal Experiments. Cancer Prevention. New Approaches for Tumor Therapy. Genes, Chromosomes and Cancer. Therapy of Brain Tumors with Laser Neurosurgery. The Genome Project. (orig.)

Current cancer research 1998

International Nuclear Information System (INIS)

Stamatiadis-Smidt, H.

1998-01-01

Topics from the Contents: The Fight against Cancer in Germany - A Critical Review. Conditions and Structures in Research. Familial Breast Cancer - A Critical Assessment. Research without Animal Experiments. Cancer Prevention. New Approaches for Tumor Therapy. Genes, Chromosomes and Cancer. Therapy of Brain Tumors with Laser Neurosurgery. The Genome Project. (orig.)

Biological and medical research with accelerated heavy ions at the Bevalac, 1974--1977

International Nuclear Information System (INIS)

Elam, S.

1977-04-01

The Bevalac, a versatile high-energy heavy-ion accelerator complex, has been in operation for less than two years. A major purpose for which the Bevalac was constructed was to explore the possibility of heavy-ion teams for therapy for certain forms of cancer. Significant progress has been made in this direction. The National Cancer Institute has recognized the advantages that these and other accelerated particles offer, and heavy ions have been included in a long-term plan for particle therapy that will assess by means of controlled therapeutic tests the value of various modalities. Since accelerated heavy ions became available, the possibility of other contributions, not planned, became apparent. We are developig a new diagnostic method known as heavy-ion radiography that has greatly increased sensitivity for soft-tissue detail and that may become a powerful tool for localizing early tumors and metastases. We have discovered that radioactive beams are formed from fragmentation of stable deflected beams. Use of these autoradioactive beams is just beginning; however, we know that these beams will be helpful in localizing the region in the body where therapy is being delivered. In addition, it has been demonstrated that instant implantation of the radioactive beam allows direct measurements of blood perfusion rates in inaccessible parts of the body, and such a technique may become a new tool for the study of fast hot atom reactions in biochemistry, tracer biology and nuclear medicine. The Bevalac will also be useful for the continuation of previously developed methods for the control of acromegaly, Cushing's disease and, on a research basis, advanced diabetes mellitus with vascular disease. The ability to make small bloodless lesions in the brain and elsewhere with heavy-ion beams has great potential for nervous-system studies and perhaps later for radioneurosurgery

Research on accelerator-driven transmutation and studies of experimental facilities

Energy Technology Data Exchange (ETDEWEB)

Takizuka, Takakazu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1997-11-01

JAERI is carrying out R and Ds on accelerator-driven transmutation systems under the national OMEGA Program that aims at development of the technology to improve efficiency and safety in the final disposal of radioactive waste. Research facilities for accelerator-driven transmutation experiments are proposed to construct within the framework of the planned JAERI Neutron Science Project. This paper describes the features of the proposed accelerator-driven transmutation systems and their technical issues to be solved. A research facility plan under examination is presented. The plan is divided in two phases. In the second phase, technical feasibility of accelerator-driven systems will be demonstrated with a 30-60 MW experimental integrated system and with a 7 MW high-power target facility. (author)

Ion Beam Facilities at the National Centre for Accelerator based Research using a 3 MV Pelletron Accelerator

Science.gov (United States)

Trivedi, T.; Patel, Shiv P.; Chandra, P.; Bajpai, P. K.

A 3.0 MV (Pelletron 9 SDH 4, NEC, USA) low energy ion accelerator has been recently installed as the National Centre for Accelerator based Research (NCAR) at the Department of Pure & Applied Physics, Guru Ghasidas Vishwavidyalaya, Bilaspur, India. The facility is aimed to carried out interdisciplinary researches using ion beams with high current TORVIS (for H, He ions) and SNICS (for heavy ions) ion sources. The facility includes two dedicated beam lines, one for ion beam analysis (IBA) and other for ion implantation/ irradiation corresponding to switching magnet at +20 and -10 degree, respectively. Ions with 60 kV energy are injected into the accelerator tank where after stripping positively charged ions are accelerated up to 29 MeV for Au. The installed ion beam analysis techniques include RBS, PIXE, ERDA and channelling.

Heavy-Ion Fusion Accelerator Research, 1992

International Nuclear Information System (INIS)

1993-06-01

The National Energy Strategy calls for a demonstration IFE power plant by the year 2025. The cornerstone of the plan to meet this ambitious goal is research and development for heavy-ion driver technology. A series of successes indicates that the technology being studied by the HIFAR Group -- the induction accelerator -- is a prime candidate for further technology development toward this long-range goal. The HIFAR program addresses the generation of high-power, high-brightness beams of heavy ions; the understanding of the scaling laws that apply in this hitherto little-explored physics regime; and the validation of new, potentially more economical accelerator strategies. Key specific elements to be addressed include: fundamental physical limits of transverse and longitudinal beam quality; development of induction modules for accelerators, along with multiple-beam hardware, at reasonable cost; acceleration of multiple beams, merging of the beams, and amplification of current without significant dilution of beam quality; final bunching, transport, and focusing onto a small target. In 1992, the HIFAR Program was concerned principally with the next step toward a driver: the design of ILSE, the Induction Linac Systems Experiments. ILSE will address most of the remaining beam-control and beam-manipulation issues at partial driver scale. A few parameters -- most importantly, the line charge density and consequently the size of the ILSE beams -- will be at full driver scale. A theory group closely integrated with the experimental groups continues supporting present-day work and looking ahead toward larger experiments and the eventual driver. Highlights of this long-range, driver-oriented research included continued investigations of longitudinal instability and some new insights into scaled experiments with which the authors might examine hard-to-calculate beam-dynamics phenomena

The CARE project - Coordinated Accelerator Research in Europe

CERN Multimedia

2003-01-01

A one-day presentation of the project will take place on Monday February 10th in the CERN Council Chamber. The meeting will start a 9am and is expected to end at 4:30pm. The meeting, which is open to the whole community, will present an initiative on accelerator R&D in Europe, supported by ECFA, with the aim to bid for European Union support through the Framework 6 scheme. This initiative is coordinated by a steering group (ESGARD - European Steering Group on Accelerator Research and Development), which has been set up to coordinate European efforts on accelerator R&D and the submission of such bids. The initial bids have to be submitted by April 15th. All those interested in accelerator R&D are welcome to attend.

Heavy-ion fusion accelerator research in the USA

International Nuclear Information System (INIS)

Bangerter, R.O.; Godlove, T.D.; Herrmannsfeldt, W.B.; Keefe, D.

1985-01-01

In October 1983, a Heavy-Ion Fusion Accelerator Research programme (HIFAR) was established under the Office of Energy Research of the United States Department of Energy. The programme goal over the next several years is to establish a data base in accelerator physics and technology that can allow the potential of heavy ion fusion to be accurately assessed. Three new developments have taken place in the HIFAR programme. First, a decision has been made to concentrate the experimental programme on the development of multiple-beam induction linacs. Second, new beam transport experiments over a large number of quadrupole elements show that stable beam propagation occurs for significantly higher beam currents than had been believed possible a few years ago. Third, design calculations now show that a test accelerator of modest size and cost can come within a factor of three of testing almost all of the physics and technical issues appropriate to a power plant driver. (author)

Moonshot Acceleration Factor: Medical Imaging.

Science.gov (United States)

Sevick-Muraca, Eva M; Frank, Richard A; Giger, Maryellen L; Mulshine, James L

2017-11-01

Medical imaging is essential to screening, early diagnosis, and monitoring responses to cancer treatments and, when used with other diagnostics, provides guidance for clinicians in choosing the most effective patient management plan that maximizes survivorship and quality of life. At a gathering of agency officials, patient advocacy organizations, industry/professional stakeholder groups, and clinical/basic science academicians, recommendations were made on why and how one should build a "cancer knowledge network" that includes imaging. Steps to accelerate the translation and clinical adoption of cancer discoveries to meet the goals of the Cancer Moonshot include harnessing computational power and architectures, developing data sharing policies, and standardizing medical imaging and in vitro diagnostics. Cancer Res; 77(21); 5717-20. ©2017 AACR . ©2017 American Association for Cancer Research.

Heavy accelerated nuclei in biomedical research

International Nuclear Information System (INIS)

Tobias, C.A.

1987-01-01

Accelerated atomic nuclei in physics accelerators have been used in basic biological research and in applied medical diagnostic and therapeutic studies for the past 50 years. The passage of single heavy particles through the cell nucleus is capable of producing multiple DNA double-strand scission and chromatin breaks. According to the Repair-Misrepair model, the high biological effectiveness of high-LET particles is due to misrepair and misrejoining of the breaks. The Bragg depth ionization effect allows heavy particles to deposit considerably more energy deep in tissue than at the surface, and this property has been used for great improvements in the radiation therapy of localized tumors. Recent advances in producing radioactive beams will allow verification of therapeutic administration of such beams. The radioactive beams also open a new field of Nuclear Medicine. There is increasing interest in building special biomedical light and heavy-ion accelerators. These will be used not only for therapy but also for diagnosis, for the study of radiation hazards in space flight, and for basic molecular and cellular understanding of the mechanisms of radiation effect

Tai Ji Quan for the aging cancer survivor: Mitigating the accelerated development of disability, falls, and cardiovascular disease from cancer treatment

Directory of Open Access Journals (Sweden)

Kerri M. Winters-Stone

2014-03-01

Full Text Available Currently there are more than 13.7 million cancer survivors living in the U.S., and that figure is projected to increase by 31% in the next decade, adding another 4 million cancer survivors into the healthcare system. Cancer is largely a disease of aging, and the aging of the population will sharply raise the proportion of older cancer survivors, many of whom will be long-term survivors (5+ years post diagnosis. This review will address the potential utility of exercise to address three health problems that are of particular concern for the aging cancer survivor and the healthcare system, i.e., disability, falls, and cardiovascular disease, because the development of these age-related problems may be accelerated by cancer treatment. While there are many different modes of exercise that each produce specific adaptations, Tai Ji Quan may be a particularly suitable strategy to mitigate the development of age- and cancer-treatment-related problems. Based on studies in older adults without cancer, Tai Ji Quan produces musculoskeletal and cardiometabolic adaptations and is more easily performed by older adults due to its low energy cost and slower movement patterns. Since cancer survivors are mostly older, inactive, and often physically limited by the lingering side effects of treatment, they need to engage in safe, practical, and effective modes of exercise. The dearth of published controlled trials examining the efficacy of Tai Ji Quan to mitigate cancer-treatment-related musculoskeletal and cardiovascular side effects points to ample research opportunities to explore the application of this non-Western exercise modality to improve long-term outcomes for aging cancer survivors.

Accelerating Research Innovation by Adopting the Lean Startup Paradigm

Directory of Open Access Journals (Sweden)

Kaisa Still

2017-05-01

Full Text Available Converting scientific expertise into marketable products and services is playing an increasingly important role in the launching of new ventures, the growth of existing firms, and the creation of new jobs. In this article, we explore how the lean startup paradigm, which validates the market for a product with a business model that can sustain subsequent scaling, has led to a new process model to accelerate innovation. We then apply this paradigm to the context of research at universities and other research organizations. The article is based on the assumption that the organizational context matters, and it shows how a deeper understanding of the research context could enable an acceleration of the innovation process. We complement theoretical examples with a case example from VTT Technical Research Institute of Finland. Our findings show that many of the concepts from early-acceleration phases – and the lean startup paradigm – can also be relevant in innovation discussions within the research context. However, the phase of value-proposition discovery is less adequately addressed, and that of growth discovery, with its emphasis on building on a scalable, sustainable business does not seem to be addressed with the presented innovation approaches from the research context. Hence, the entrepreneurial activities at the research context differ from those in startups and internal startups in established organizations.

Accelerator based research facility as an inter university centre

International Nuclear Information System (INIS)

Mehta, G.K.

1995-01-01

15 UD pelletron has been operating as a user facility from July 1991. It is being utilised by a large number of universities and other institutions for research in basic Nuclear Physics, Materials Science, Atomic Physics, Radiobiology and Radiation Chemistry. There is an on-going programme for augmenting the accelerator facilities by injecting Pelletron beams into superconducting linear accelerator modules. Superconducting niobium resonator is being developed in Argonne National Laboratory as a joint collaborative effort. All other things such as cryostats, rf instrumentation, cryogenic distribution system, computer control etc are being done indigenously. Research facilities, augmentation plans and the research being conducted by the universities in various disciplines are described. (author)

High intensity linear accelerator development topics for panel discussion on ''Nuclear Energy Research and Accelerators: Future Prospects''

International Nuclear Information System (INIS)

Jameson, R.A.

1989-01-01

Two companion papers at this meeting have introduced the subject of high intensity linacs for materials research and for radioactive waste transmutation; Prof. Kaneko's paper ''Intense Proton Accelerator,'' and my paper ''Accelerator-Based Intense Neutron Source for Materials R ampersand D.'' I will expand on those remarks to briefly outline some of the extensive work that has been done at Los Alamos toward those two application areas, plus a third --- the production of tritium in an accelerator-based facility (APT--Accelerator Production of Tritium). 1 ref., 11 figs

Natural and Accelerated Bioremediation Research (NABIR) Field Research Center (FRC) Management Plan

Energy Technology Data Exchange (ETDEWEB)

Watson, D.B.

2002-02-28

The Environmental Sciences Division at Oak Ridge National Laboratory has established a Field Research Center (FRC) to support the Natural and Accelerated Bioremediation Research (NABIR) Program on the U.S. Department of Energy (DOE) Oak Ridge Reservation in Oak Ridge, Tennessee for the DOE Headquarters Office of Biological and Environmental Research within the Office of Science.

Brookhaven National Laboratory's Accelerator Test Facility: research highlights and plans

Science.gov (United States)

Pogorelsky, I. V.; Ben-Zvi, I.

2014-08-01

The Accelerator Test Facility (ATF) at Brookhaven National Laboratory has served as a user facility for accelerator science for over a quarter of a century. In fulfilling this mission, the ATF offers the unique combination of a high-brightness 80 MeV electron beam that is synchronized to a 1 TW picosecond CO2 laser. We unveil herein our plan to considerably expand the ATF's floor space with an upgrade of the electron beam's energy to 300 MeV and the CO2 laser's peak power to 100 TW. This upgrade will propel the ATF even further to the forefront of research on advanced accelerators and radiation sources, supporting the most innovative ideas in this field. We discuss emerging opportunities for scientific breakthroughs, including the following: plasma wakefield acceleration studies in research directions already active at the ATF; laser wakefield acceleration (LWFA), where the longer laser wavelengths are expected to engender a proportional increase in the beam's charge while our linac will assure, for the first time, the opportunity to undertake detailed studies of seeding and staging of the LWFA; proton acceleration to the 100-200 MeV level, which is essential for medical applications; and others.

Accelerator ampersand Fusion Research Division 1991 summary of activities

International Nuclear Information System (INIS)

1991-12-01

This report discusses research projects in the following areas: Heavy-ion fusion accelerator research; magnetic fusion energy; advanced light source; center for x-ray optics; exploratory studies; superconducting magnets; and bevalac operations

Accelerator and fusion research division. 1992 Summary of activities

Energy Technology Data Exchange (ETDEWEB)

1992-12-01

This report contains brief discussions on research topics in the following area: Heavy-Ion Fusion Accelerator Research; Magnetic Fusion Energy; Advanced Light Source; Center for Beam Physics; Superconducting Magnets; and Bevalac Operations.

Candidate Cancer Allele cDNA Collection | Office of Cancer Genomics

Science.gov (United States)

CTD2 researchers at the Broad Institute/DFCI have developed a collection of plasmids including mutant alleles found in sequencing studies of cancer. It includes somatic variants found in lung adenocarcinoma and across other cancer types. The clones enable researchers to characterize the function of the cancer variants in a high throughput experiments. These plasmids are collectively called the “Broad Target Accelerator Plasmid Collections”.

Accelerator-driven nuclear synergetic systems-an overview of the research activities in Sweden

International Nuclear Information System (INIS)

Conde, H.; Baecklin, A.; Carius, S.

1995-01-01

The rapid development of the accelerator technology which enables the construction of reliable and very intense neutron sources has initiated a growing interest for accelerator driven transmutation systems in Sweden. After the Specialist Meeting on Accelerator-Driven Transmutation Technology for Radwaste and other Applications on 24-28 June 1991 at Saltsjoebaden, Sweden, the research activities oriented towards accelerator-driven systems have been started at several research centers in Sweden. Also the governmental agencies responsible for the spent fuel policy showed a positive attitude to these activities through a limited financial support, particularly for studies of the safety aspects of these systems. Also the nuclear power industry and utilities show a positive interest in the research on these concepts. The present paper presents an overview of the Swedish research activities on accelerator-driven systems and the proposed future coordination, organizations and prospects for this research in the context of the national nuclear energy and spent fuel policy. The Swedish perspective for international cooperation is also described

Accelerator-driven nuclear synergetic systems-an overview of the research activities in Sweden

Energy Technology Data Exchange (ETDEWEB)

Conde, H.; Baecklin, A.; Carius, S. [Uppsala Univ. (Sweden)] [and others

1995-10-01

The rapid development of the accelerator technology which enables the construction of reliable and very intense neutron sources has initiated a growing interest for accelerator driven transmutation systems in Sweden. After the Specialist Meeting on Accelerator-Driven Transmutation Technology for Radwaste and other Applications on 24-28 June 1991 at Saltsjoebaden, Sweden, the research activities oriented towards accelerator-driven systems have been started at several research centers in Sweden. Also the governmental agencies responsible for the spent fuel policy showed a positive attitude to these activities through a limited financial support, particularly for studies of the safety aspects of these systems. Also the nuclear power industry and utilities show a positive interest in the research on these concepts. The present paper presents an overview of the Swedish research activities on accelerator-driven systems and the proposed future coordination, organizations and prospects for this research in the context of the national nuclear energy and spent fuel policy. The Swedish perspective for international cooperation is also described.

Advanced Accelerator Development Strategy Report: DOE Advanced Accelerator Concepts Research Roadmap Workshop

Energy Technology Data Exchange (ETDEWEB)

None, None

2016-02-03

Over a full two day period, February 2–3, 2016, the Office of High Energy Physics convened a workshop in Gaithersburg, MD to seek community input on development of an Advanced Accelerator Concepts (AAC) research roadmap. The workshop was in response to a recommendation by the HEPAP Accelerator R&D Subpanel [1] [2] to “convene the university and laboratory proponents of advanced acceleration concepts to develop R&D roadmaps with a series of milestones and common down selection criteria towards the goal for constructing a multi-TeV e+e– collider” (the charge to the workshop can be found in Appendix A). During the workshop, proponents of laser-driven plasma wakefield acceleration (LWFA), particle-beam-driven plasma wakefield acceleration (PWFA), and dielectric wakefield acceleration (DWFA), along with a limited number of invited university and laboratory experts, presented and critically discussed individual concept roadmaps. The roadmap workshop was preceded by several preparatory workshops. The first day of the workshop featured presentation of three initial individual roadmaps with ample time for discussion. The individual roadmaps covered a time period extending until roughly 2040, with the end date assumed to be roughly appropriate for initial operation of a multi-TeV e+e– collider. The second day of the workshop comprised talks on synergies between the roadmaps and with global efforts, potential early applications, diagnostics needs, simulation needs, and beam issues and challenges related to a collider. During the last half of the day the roadmaps were revisited but with emphasis on the next five to ten years (as specifically requested in the charge) and on common challenges. The workshop concluded with critical and unanimous endorsement of the individual roadmaps and an extended discussion on the characteristics of the common challenges. (For the agenda and list of participants see Appendix B.)

Hadron cancer therapy complex using nonscaling fixed field alternating gradient accelerator and gantry design

Directory of Open Access Journals (Sweden)

E. Keil

2007-05-01

Full Text Available Nonscaling fixed field alternating gradient (FFAG rings for cancer hadron therapy offer reduced physical aperture and large dynamic aperture as compared to scaling FFAGs. The variation of tune with energy implies the crossing of resonances during acceleration. Our design avoids intrinsic resonances, although imperfection resonances must be crossed. We consider a system of three nonscaling FFAG rings for cancer therapy with 250 MeV protons and 400   MeV/u carbon ions. Hadrons are accelerated in a common radio frequency quadrupole and linear accelerator, and injected into the FFAG rings at v/c=0.1294. H^{+}/C^{6+} ions are accelerated in the two smaller/larger rings to 31 and 250  MeV/68.8 and 400   MeV/u kinetic energy, respectively. The lattices consist of doublet cells with a straight section for rf cavities. The gantry with triplet cells accepts the whole required momentum range at fixed field. This unique design uses either high-temperature superconductors or superconducting magnets reducing gantry magnet size and weight. Elements with a variable field at the beginning and at the end set the extracted beam at the correct position for a range of energies.

Accelerator ampersand Fusion Research Division: 1993 Summary of activities

International Nuclear Information System (INIS)

Chew, J.

1994-04-01

The Accelerator and Fusion Research Division (AFRD) is not only one of the largest scientific divisions at LBL, but also the one of the most diverse. Major efforts include: (1) investigations in both inertial and magnetic fusion energy; (2) operation of the Advanced Light Source, a state-of-the-art synchrotron radiation facility; (3) exploratory investigations of novel radiation sources and colliders; (4) research and development in superconducting magnets for accelerators and other scientific and industrial applications; and (5) ion beam technology development for nuclear physics and for industrial and biomedical applications. Each of these topics is discussed in detail in this book

A facility for accelerator research and education at Fermilab

International Nuclear Information System (INIS)

Church, Mike; Nagaitsev, Sergei

2009-01-01

Fermilab is currently constructing the 'SRF Test Accelerator at the New Muon Lab' (NML). NML consists of a photo-emitted RF electron gun, followed by a bunch compressor, low energy test beamlines, SCRF accelerating structures, and high energy test beamlines. The initial primary purpose of NML will be to test superconducting RF accelerating modules for the ILC and for Fermilab's 'Project X' - a proposal for a high intensity proton source. The unique capability of NML will be to test these modules under conditions of high intensity electron beams with ILC-like beam parameters. In addition NML incorporates a photoinjector which offers significant tunability and especially the possibility to generate a bright electron beam with brightness comparable to state-of-the-art accelerators. This opens the exciting possibility of also using NML for fundamental beams research and tests of new concepts in beam manipulations and acceleration, instrumentation, and the applications of beams.

Cancer research priorities and gaps in Iran: the influence of cancer burden on cancer research outputs between 1997 and 2014.

Science.gov (United States)

Majidi, A; Salimzadeh, H; Beiki, O; Delavari, F; Majidi, S; Delavari, A; Malekzadeh, R

2017-03-01

As a developing country, Iran is experiencing the increasing burden of cancers, which are currently the third leading cause of mortality in Iran. This study aims to demonstrate that cancer research in Iran concentrates on the cancer research priorities based on the global burden of disease (GBD) reports. Descriptive evaluation of all cancers disability-adjusted life years (DALYs) was performed using GBD data. Also a comprehensive search was conducted using cancer-associated keywords to obtain all cancer-related publications from Iran, indexed in Web of Science. Multiple regression analysis and correlation coefficients (R 2 ) were used to evaluate the possible associations between cancer research publications and GBD. During 1996-2014, the majority of cancer-related publications in Iran focused on breast cancer, leukaemia and stomach cancer, respectively. This study found hypothetical correlations between cancer publications in Iran in line with the burden of cancer as reported by GBD. Particularly, correlations between years lived with disability (YLD) and cancer-related publications were more obvious. This study introduces a new outline in setting cancer research priorities in the region. Copyright © 2016 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death

Directory of Open Access Journals (Sweden)

Frederick J. Kohlhapp

2016-10-01

Full Text Available In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8+ T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1. Immunotherapy to block PD-1 reverses this loss of anti-tumor CD8+ T cells from the tumor and decreases infection-induced tumor growth. Our findings show that acute non-oncogenic infection can promote cancer growth, raising concerns regarding acute viral illness sequelae. They also suggest an unexpected role for PD-1 blockade in cancer immunotherapy and provide insight into the immune response when faced with concomitant challenges.

Effluent Monitoring System Design for the Proton Accelerator Research Center of PEFP

International Nuclear Information System (INIS)

Kim, Jun Yeon; Mun, Kyeong Jun; Cho, Jang Hyung; Jo, Jeong Hee

2010-01-01

Since host site host site was selected Gyeong-ju city in January, 2006. we need design revision of Proton Accelerator research center to reflect on host site characteristics and several conditions. Also the IAC recommended maximization of space utilization and construction cost saving. After GA(General Arrangement) is made a decision, it is necessary to evaluate the radiation analysis of every controlled area in the proton accelerator research center such as accelerator tunnel, Klystron gallery, beam experimental hall, target rooms and ion beam application building to keep dose rate below the ALARA(As Low As Reasonably achievable) objective. Our staff has reviewed and made a shielding design of them. In this paper, According to accelerator operation mode and access conditions based on radiation analysis and shielding design, we made the exhaust system configuration of controlled area in the proton accelerator research center. Also, we installed radiation monitor and set its alarm value for each radiation area

CPRIT/Johnson Space Center, September, 2011 (Cancer Prevention and Research Institute of Texas)

Science.gov (United States)

Davis, Jeffrey; Lane, Helen; Baker, Tracey; Cucinotta, Francis; Wu, Honglu

2011-01-01

JSC researchers study carcinogenesis, cancer prevention and treatment along with epidemiological (primarily retrospective and longitudinal) studies, modeling, and interactions with the environment such as radiation, nutritional, and endocrine changes related to space flight along with behaviors such as smoking. Cancer research is a major focus for human space flight due to the exposure to space radiation which consists of particles of varying charges and energies, and secondary neutrons. The JSC laboratories collaborate with investigators from the U.S. as well as our European and Japanese partners. We use accelerator facilities at the Brookhaven National Laboratory, Loma Linda University and Los Alamos National Laboratory that generate high energy charged particles and neutrons to simulate cosmic radiation and solar particle events. The research using cultured cells and animals concentrates on damage and repair from the level of DNA to organ tissues, due to exposure to simulated space radiation exposure, that contribute to the induction of leukemia and solid tumors in most major tissues such as lung, colon, liver and breast. The goal of the research is to develop a mathematical model that can predict cancer morbidity and mortality risks with sufficient accuracy for a given space mission.

CARE05 coordinated accelerator research in Europe

CERN Multimedia

2005-01-01

Annual Meeting at CERN, 23-25 November 2005 CARE started on 1st January 2004 and will last for five years. At the end of each year it holds a general meeting to report on the progress and status of its activities. This year, the CARE annual meeting is taking place at CERN The objective of the CARE project is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The program includes the most advanced scientific and technological developments, relevant to accelerator research for Particle Physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe's ability to evaluate and develop methods of producing intense and high energy beams of electrons, protons, muons and neutrinos. These activities are embedded in world-wide efforts towards future e+e- linear colliders, superior neutrino beam fa...

CARE07 Coordinated Accelerator Research in Europe

CERN Multimedia

2007-01-01

Annual Meeting, at CERN, 29-31 October 2007 The CARE project started on 1st January 2004 and will end on 31st December 2008. At the end of each year, the progress and status of its activities are reported in a general meeting. This year, the meeting takes place at CERN. The CARE objective is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The programme includes the most advanced scientific and technological developments, relevant to accelerator research for particle physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe’s ability to produce intense and high-energy particle beams (electrons and positrons, muons and neutrinos, protons and ions, respectively). The Joint Activities, SRF, PHIN, HIPPI and NED, aim at technical developments on s...

CARE07 Coordinated Accelerator Research in Europe

CERN Multimedia

2007-01-01

Annual Meeting, at CERN, 29-31 October 2007 The CARE project started on 1st January 2004 and will end on 31st December 2008. At the end of each year, the progress and status of its activities are reported in a general meeting. This year, the meeting is taking place at CERN. The CARE objective is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The programme includes the most advanced scientific and technological developments, relevant to accelerator research for particle physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe’s ability to produce intense and high-energy particle beams (electrons and positrons, muons and neutrinos, protons and ions, respectively). The Joint Activities, SRF, PHIN, HIPPI and NED, aim at technical developments ...

Possibilities of basic and applied researches using low energy ion beams accelerators

International Nuclear Information System (INIS)

Morales, Roberto

1996-01-01

Full text: The availability of ion sources that allow to accelerate heavy and light ions, and the new compact accelerators have opened interesting possibilities for using in basic and applied research, Some of the research lines such as material, environmental, archaeology, bio-medicine are shown

The BMC Medicine breast cancer collection: an illustration of contemporary research and clinical care.

Science.gov (United States)

Tripathy, Debu

2015-09-23

The field of breast cancer had witnessed clear improvements in survival and less morbidity over the last few decades owing to earlier detection as a result of public awareness and screening, as well as treatments involving the disciplines of surgical, radiation and medical oncology along with advances in imaging and pathological diagnostics. However, in the last 5-10 years, newer assays and biological therapies have begun to cross new boundaries with higher rates of cure seen in more aggressive cancers. Even though metastatic breast cancer remains incurable, some, but not all, subsets of patients with breast cancer are living longer and more productive lives. Many challenges still remain, and the development of team science coupled with collaborative clinical research and care is expected to accelerate advances along this trajectory.

International topical meeting on nuclear research applications and utilization of accelerators. Book of abstracts

International Nuclear Information System (INIS)

2009-01-01

Applications of particle accelerators cover a number of areas, from strategic and applied research, safety and security, environmental applications, materials research and analytical sciences, to radioisotope production and radiation processing. Accelerator based techniques and pulsed neutron sources are expected to lead to new initiatives in materials research of relevance for both the nuclear and non-nuclear fields. Material science studies with the use of accelerators, neutron beams and other nuclear analytical methods are relevant to the development of advanced reactors, nuclear fuel cycle needs and fusion research. In this regard, a better understanding of the irradiation effects in materials for energy and non-energy applications is needed, and is reflected in accelerator techniques for modification and analysis of materials for nuclear technologies. Accelerator applications for innovative nuclear systems aiming at rad-waste transmutation (e.g., accelerator driven systems) are being pursued in many countries. Research and development using accelerators involves a broad spectrum of skills to build a cadre of trained experts in nuclear techniques in IAEA Member States, and to generate knowledge for innovative methodologies and tools. The present conference is also being held in cooperation with the American Nuclear Society (ANS), which successfully organized the series of accelerator applications conferences known as AccApp. The ANS series of topical meetings has provided a forum for the global exchange of scientific and technical knowledge on a wide variety of related topics since the first AccApp took place in 1997 in Albuquerque, USA. The last conference which was held in 2007 in Pocatello, USA, was jointly organized by the ANS and the IAEA. The main objectives of the conference are to promote exchange of information among IAEA Member States representatives/delegates and to discuss new trends in accelerator applications including nuclear materials research

Annual report of Department of Research Reactors and Tandem Accelerator, JFY2006. Operation, utilization and technical development of JRR-3, JRR-4, NSRR and Tandem Accelerator

International Nuclear Information System (INIS)

2007-12-01

The Department of Research Reactors and Tandem Accelerator is in charge of the operation, utilization and technical development of JRR-3 (Japan Research Reactor-3), JRR-4 (Japan Research Reactor-4) and NSRR (Nuclear Safety Research Reactor) and Tandem Accelerator. The following services and technical developments were achieved in Japanese Fiscal Year 2006: 1) JRR-3 was operated for 181 days in 7 cycles and JRR-4 for 149 days in 37 cycles to provide neutrons for research and development of in-house and outside users. 2) JRR-3 and JRR-4 were utilized through deliberate coordination as follows, a) Neutron irradiations of 628 materials, for neutron transmutation doping of silicon etc. b) Capsule irradiations of 3,067 samples, for neutron activation analyses etc. c) Neutron beam experiments of 6,338 cases x days. 3) Concerning to the 10 times increasing plan of cold neutron beams from JRR-3, a pressure resistant test model of the high-performance neutron moderator vessel which had been designed to increase cold neutrons twice as much as the present one was fabricated. Various developments for upgrading cold neutron guide tubes with super mirrors were in progress. 4) Boron neutron capture therapy was carried out 34 times using JRR-4. Improved neutron collimators were built to fit well to any irregular outline for cancer around the neck. 5) NSRR carried out 4 times of pulse irradiations of high burn-up MOX fuels and 9 times of un-irradiated fuels to contribute to fuel safety researches. 6) The Tandem Accelerator was operated for 201 days to contribute to the researches of nuclear physics and solid state physics with high energy heavy ions. The new utilization program of sharing beam times with outside users was performed by carrying out 45 days. The beam intensity increasing program with a high performance ion source, in place of the compact one which has been working in the high voltage terminal, has made great progress. (author)

LIBO accelerates

CERN Multimedia

2002-01-01

The prototype module of LIBO, a linear accelerator project designed for cancer therapy, has passed its first proton-beam acceleration test. In parallel a new version - LIBO-30 - is being developed, which promises to open up even more interesting avenues.

Annual report of Department of Research Reactor and Tandem Accelerator, JFY2007. Operation, utilization and technical development of JRR-3, JRR-4, NSRR and tandem accelerator

International Nuclear Information System (INIS)

Miyazaki, Osamu; Awa, Yasuaki; Isaka, Koji; Kutsukake, Kenichi; Komeda, Masao; Shibata, Ko; Hiyama, Kazuhisa; Suzuki, Mayu; Sone, Takuya; Ohuchi, Tomoaki; Terakado, Yuichi; Sataka, Masao

2009-06-01

The Department of Research Reactors and Tandem Accelerator is in charge of the operation, utilization and technical development of JRR-3(Japan Research Reactor-3), JRR-4(Japan Research Reactor-4), NSRR(Nuclear Safety Research Reactor) and Tandem Accelerator. This annual report describes a summary of activities of services and technical developments carried out in the period between April 1, 2007 and March 31, 2008. The activities were categorized into five service/development fields: (1) Operation and maintenance of research reactors and tandem accelerator. (2) Utilization of research reactors and tandem accelerator. (3) Upgrading of utilization techniques of research reactors and tandem accelerator. (4) Safety administration for research reactors and tandem accelerator. (5) International cooperation. Also contained are lists of publications, meetings, granted permissions on lows and regulations concerning atomic energy, commendation, plans and outcomes in service and technical developments and so on. (author)

Annual report of Department of Research Reactor and Tandem Accelerator, JFY2010. Operation, utilization and technical development of JRR-3, JRR-4, NSRR and Tandem Accelerator

International Nuclear Information System (INIS)

Ishii, Tetsuro; Nakamura, Kiyoshi; Kawamata, Satoshi; Yamada, Yusuke; Kawashima, Kazuhiro; Asozu, Takuhiro; Nakamura, Takemi; Arai, Masaji; Yoshinari, Shuji; Sataka, Masao

2012-03-01

The Department of Research Reactors and Tandem Accelerator is in charge of the operation, utilization and technical development of JRR-3(Japan Research Reactor No.3), JRR-4(Japan Research Reactor No.4), NSRR(Nuclear Safety Research Reactor) and Tandem Accelerator. This annual report describes a summary of activities of services and technical developments carried out in the period between April 1, 2010 and March 31, 2011. The activities were categorized into five service/development fields: (1) Operation and maintenance of research reactors and tandem accelerator, (2) Utilization of research reactors and tandem accelerator, (3) Upgrading of utilization techniques of research reactors and tandem accelerator, (4) Safety administration for research reactors and tandem accelerator, (5) International cooperation. Also contained are lists of publications, meetings, granted permissions on lows and regulations concerning atomic energy, commendation, outcomes in service and technical developments and so on. (author)

Discovery machines accelerators for science, technology, health and innovation

CERN Document Server

Australian Academy of Sciences

2016-01-01

Discovery machines: Accelerators for science, technology, health and innovation explores the science of particle accelerators, the machines that supercharge our ability to discover the secrets of nature and have opened up new tools in medicine, energy, manufacturing, and the environment as well as in pure research. Particle accelerators are now an essential ingredient in discovery science because they offer new ways to analyse the world, such as by probing objects with high energy x-rays or colliding them beams of electrons. They also have a huge—but often unnoticed—impact on all our lives; medical imaging, cancer treatment, new materials and even the chips that power our phones and computers have all been transformed by accelerators of various types. Research accelerators also provide fundamental infrastructure that encourages better collaboration between international and domestic scientists, organisations and governments.

SINP MSU accelerator facility and applied research

International Nuclear Information System (INIS)

Chechenin, N.G.; Ishkhanov, B.S.; Kulikauskas, V.S.; Novikov, L.S.; Pokhil, G.P.; Romanovskii, E.A.; Shvedunov, V.I.; Spasskii, A.V.

2004-01-01

Full text: SINP accelerator facility includes 120 cm cyclotron, electrostatic generator with the upper voltage 3.0 MeV, electrostatic generator with the upper voltage 2.5 MeV, Cocroft -Walton generator with the upper voltage 500 keV, 150 keV accelerator for solid microparticles. A new generation of electron beam accelerators has been developed during the last decade. The SINP accelerator facility will be shortly described in the report. A wide range of basic research in nuclear and atomic physics, physics of ion-beam interactions with condensed matter is currently carried out. SINP activity in the applied research is concentrated in the following areas of materials science: - Materials diagnostics with the Rutherford backscattering techniques (RBS) and channeling of ions (RBS/C). A large number of surface ad-layers and multilayer systems for advanced micro- and nano-electronic technology have been investigated. A selected series of examples will be illustrated. - Concentration depth profiles of hydrogen by the elastic recoils detection techniques (ERD). Primarily, the hydrogen depth profiles in perspective materials for thermonuclear reactors have been investigated. - Lattice site locations of hydrogen by a combination of ERD and channeling techniques. This is a new technique which was successfully applied for investigation of hydrogen and hydrogen-defect complexes in silicon for the smart-cut technology. - Light element diagnostics by RBS and nuclear backscattering techniques (NBS). The technique is illustrated by applications for nitrogen concentration profiling in steels. Nitrogen take-up and release, nitrides precipitate formation will be illustrated. - New medium energy ion scattering (MEIS) facility and applications. Ultra-high vacuum and superior energy resolution electrostatic toroidal analyzer is designed to be applied for characterization of composition and structure of several upper atomic layers of materials

Accelerator and Fusion Research Division: summary of activities, 1983

International Nuclear Information System (INIS)

1984-08-01

The activities described in this summary of the Accelerator and Fusion Research Division are diverse, yet united by a common theme: it is our purpose to explore technologically advanced techniques for the production, acceleration, or transport of high-energy beams. These beams may be the heavy ions of interest in nuclear science, medical research, and heavy-ion inertial-confinement fusion; they may be beams of deuterium and hydrogen atoms, used to heat and confine plasmas in magnetic fusion experiments; they may be ultrahigh-energy protons for the next high-energy hadron collider; or they may be high-brilliance, highly coherent, picosecond pulses of synchrotron radiation

Why I Do Cancer Research

Science.gov (United States)

World Cancer Research Day is recognized on September 24, 2017. This day presents an opportunity for all of us to remind the world of the critically important roles research and cancer researchers play in reducing the global burden of cancer. Together with ten other global partners, NCI participated in the planning and launch of this initiative, highlighting the amplified impact of international cooperation in the clinical research arena.

Health psychology and translational genomic research: bringing innovation to cancer-related behavioral interventions.

Science.gov (United States)

McBride, Colleen M; Birmingham, Wendy C; Kinney, Anita Y

2015-01-01

The past decade has witnessed rapid advances in human genome sequencing technology and in the understanding of the role of genetic and epigenetic alterations in cancer development. These advances have raised hopes that such knowledge could lead to improvements in behavioral risk reduction interventions, tailored screening recommendations, and treatment matching that together could accelerate the war on cancer. Despite this optimism, translation of genomic discovery for clinical and public health applications has moved relatively slowly. To date, health psychologists and the behavioral sciences generally have played a very limited role in translation research. In this report we discuss what we mean by genomic translational research and consider the social forces that have slowed translational research, including normative assumptions that translation research must occur downstream of basic science, thus relegating health psychology and other behavioral sciences to a distal role. We then outline two broad priority areas in cancer prevention, detection, and treatment where evidence will be needed to guide evaluation and implementation of personalized genomics: (a) effective communication, to broaden dissemination of genomic discovery, including patient-provider communication and familial communication, and (b) the need to improve the motivational impact of behavior change interventions, including those aimed at altering lifestyle choices and those focusing on decision making regarding targeted cancer treatments and chemopreventive adherence. We further discuss the role that health psychologists can play in interdisciplinary teams to shape translational research priorities and to evaluate the utility of emerging genomic discoveries for cancer prevention and control. PsycINFO Database Record (c) 2015 APA, all rights reserved.

Review of Compact Commercial Accelerator Products and Applications.

Science.gov (United States)

Jongen, Y.

1997-05-01

Historically, particle accelerators were developed initially for nuclear, then for particle physics research. From this research resulted applications of accelerators in the field of medicine and industry. These application-oriented accelerators are generally built commercially, and they often emphasize other qualities than the accelerators for research. The research applications frequently require energies or beam qualities at the limit of the existing technologies. They offer the largest flexibility in term of particles and beam properties, but are more complex, more expensive and often require large and highly qualified staff to operate and maintain them. In contrast, most applications are done with low to moderate energy protons or electrons, but often with large average beam power. The accelerators are generally specialized for a specific application, and are therefore very simple and inexpensive to operate. The author will review some applications in the field of medicine, such as the production of radio-isotopes for medical diagnostic or the production of electrons, protons or fast neutron beams for cancer therapy. In the industrial field, high power electron beam are used for sterilization and for the modification of materials. Log No. 1001

Annual report of Department of Research Reactor and Tandem Accelerator, JFY2011. Operation, utilization and technical development of JRR-3, JRR-4, NSRR and tandem accelerator

International Nuclear Information System (INIS)

Ishii, Tetsuro; Nakamura, Kiyoshi; Kawamata, Satoshi; Ishikuro, Yasuhiro; Kawashima, Kazuhito; Kabumoto, Hiroshi; Nakamura, Takemi; Tamura, Itaru; Kawasaki, Sayuri; Sataka, Masao

2013-03-01

The Department of Research Reactors and Tandem Accelerator is in charge of the operation, utilization and technical development of JRR-3(Japan Research Reactor No.3), JRR-4(Japan Research Reactor No.4), NSRR(Nuclear Safety Research Reactor) and Tandem Accelerator. This annual report describes a summary of activities of services and technical developments carried out in the period between April 1, 2011 and March 31, 2012. The activities were categorized into six service/development fields: (1) Recovery from the Great East Japan Earthquake, (2) Operation and maintenance of research reactors and tandem accelerator, (3) Utilization of research reactors and tandem accelerator, (4) Upgrading of utilization techniques of research reactors and tandem accelerator, (5) Safety administration for research reactors and tandem accelerator, (6) International cooperation. Also contained are lists of publications, meetings, granted permissions on lows and regulations concerning atomic energy, number of staff members dispatched to Fukushima for the technical assistance, commendation, outcomes in service and technical developments and so on. (author)

Database application research in real-time data access of accelerator control system

International Nuclear Information System (INIS)

Chen Guanghua; Chen Jianfeng; Wan Tianmin

2012-01-01

The control system of Shanghai Synchrotron Radiation Facility (SSRF) is a large-scale distributed real-time control system, It involves many types and large amounts of real-time data access during the operating. Database system has wide application prospects in the large-scale accelerator control system. It is the future development direction of the accelerator control system, to replace the differently dedicated data structures with the mature standardized database system. This article discusses the application feasibility of database system in accelerators based on the database interface technology, real-time data access testing, and system optimization research and to establish the foundation of the wide scale application of database system in the SSRF accelerator control system. Based on the database interface technology, real-time data access testing and system optimization research, this article will introduce the application feasibility of database system in accelerators, and lay the foundation of database system application in the SSRF accelerator control system. (authors)

Strategic Plans to Promote Head and Neck Cancer Translational Research Within the Radiation Therapy Oncology Group: A Report From the Translational Research Program

International Nuclear Information System (INIS)

Chung, Christine H.; Wong, Stuart; Ang, K. Kian; Hammond, Elizabeth H.; Dicker, Adam P.; Harari, Paul M.; Le, Quynh-Thu

2007-01-01

Head and neck cancer is the fifth most common cancer in the United States, with an overall survival rate of approximately 40-50%. In an effort to improve patient outcomes, research efforts designed to maximize benefit and reduce toxicities of therapy are in progress. Basic research in cancer biology has accelerated this endeavor and provided preclinical data and technology to support clinically relevant advances in early detection, prognostic and predictive biomarkers. Recent completion of the Human Genome Project has promoted the rapid development of novel 'omics' technologies that allow more broad based study from a systems biology perspective. However, clinically relevant application of resultant gene signatures to clinical trials within cooperative groups has advanced slowly. In light of the large numbers of variables intrinsic to biomarker studies, validation of preliminary data for clinical implementation presents a significant challenge and may only be realized with large trials that involve significant patient numbers. The Radiation Therapy Oncology Group (RTOG) Head and Neck Cancer Translational Research Program recognizes this problem and brings together three unique features to facilitate this research: (1) availability of large numbers of clinical specimens from homogeneously treated patients through multi-institutional clinical trials; (2) a team of physicians, scientists, and staff focused on patient-oriented head-and-neck cancer research with the common goal of improving cancer care; and (3) a funding mechanism through the RTOG Seed Grant Program. In this position paper we outline strategic plans to further promote translational research within the framework of the RTOG

Researchers studying alternative to bladder removal for bladder cancer patients | Center for Cancer Research

Science.gov (United States)

A new phase I clinical trial conducted by researchers at the Center for Cancer Research (CCR) is evaluating the safety and tolerability, or the degree to which any side effects can be tolerated by patients, of a two-drug combination as a potential alternative to bladder removal for bladder cancer patients. The trial targets patients with non-muscle invasive bladder cancer (NMIBC) whose cancers have stopped responding to traditional therapies. Read more...

The Soreq Applied Research Accelerator Facility (SARAF): Overview, research programs and future plans

Science.gov (United States)

Mardor, Israel; Aviv, Ofer; Avrigeanu, Marilena; Berkovits, Dan; Dahan, Adi; Dickel, Timo; Eliyahu, Ilan; Gai, Moshe; Gavish-Segev, Inbal; Halfon, Shlomi; Hass, Michael; Hirsh, Tsviki; Kaiser, Boaz; Kijel, Daniel; Kreisel, Arik; Mishnayot, Yonatan; Mukul, Ish; Ohayon, Ben; Paul, Michael; Perry, Amichay; Rahangdale, Hitesh; Rodnizki, Jacob; Ron, Guy; Sasson-Zukran, Revital; Shor, Asher; Silverman, Ido; Tessler, Moshe; Vaintraub, Sergey; Weissman, Leo

2018-05-01

The Soreq Applied Research Accelerator Facility (SARAF) is under construction in the Soreq Nuclear Research Center at Yavne, Israel. When completed at the beginning of the next decade, SARAF will be a user facility for basic and applied nuclear physics, based on a 40 MeV, 5 mA CW proton/deuteron superconducting linear accelerator. Phase I of SARAF (SARAF-I, 4 MeV, 2 mA CW protons, 5 MeV 1 mA CW deuterons) is already in operation, generating scientific results in several fields of interest. The main ongoing program at SARAF-I is the production of 30 keV neutrons and measurement of Maxwellian Averaged Cross Sections (MACS), important for the astrophysical s-process. The world leading Maxwellian epithermal neutron yield at SARAF-I (5 × 10^{10} epithermal neutrons/s), generated by a novel Liquid-Lithium Target (LiLiT), enables improved precision of known MACSs, and new measurements of low-abundance and radioactive isotopes. Research plans for SARAF-II span several disciplines: precision studies of beyond-Standard-Model effects by trapping light exotic radioisotopes, such as 6He, 8Li and 18, 19, 23Ne, in unprecedented amounts (including meaningful studies already at SARAF-I); extended nuclear astrophysics research with higher energy neutrons, including generation and studies of exotic neutron-rich isotopes relevant to the rapid (r-) process; nuclear structure of exotic isotopes; high energy neutron cross sections for basic nuclear physics and material science research, including neutron induced radiation damage; neutron based imaging and therapy; and novel radiopharmaceuticals development and production. In this paper we present a technical overview of SARAF-I and II, including a description of the accelerator and its irradiation targets; a survey of existing research programs at SARAF-I; and the research potential at the completed facility (SARAF-II).

Accelerator development programme in India - an outlook

International Nuclear Information System (INIS)

Bhandari, R.K.

2011-01-01

With the construction of the VEC, Indus-1, Indus-2, superconducting cyclotron, superconducting heavy ion linac boosters etc. and implementation of other accelerator R and D programmes, we are now 'equipped' to take a quantum jump in the accelerator field. We have highly trained and skilled manpower that can take up challenges in this rapidly growing field both for research as well as applications. Serious planning is going on in the country to construct accelerator facilities for versatile Rare Ion Beams (RIB), powerful spallation source, advanced synchrotron source, high power beam for ADS etc. There is strong demand by the medical community for a proton/heavy ion cancer therapy facility and for accelerator-produced radioisotopes for medical diagnostics. Proliferation of accelerators in the industry field is long overdue in our country and welcome realization is coming. In this presentation a glimpse of the intended growth of accelerator field in the country will be given. Interesting challenges are there not only for the accelerator community, which has to grow, but also for the industry. Since the general trend is now to construct high intensity and high beam power accelerators - both for research as well as applications - the associated problems of radiation safety will be highlighted. (author)

A comparison of robotic arm versus gantry linear accelerator stereotactic body radiation therapy for prostate cancer.

Science.gov (United States)

Avkshtol, Vladimir; Dong, Yanqun; Hayes, Shelly B; Hallman, Mark A; Price, Robert A; Sobczak, Mark L; Horwitz, Eric M; Zaorsky, Nicholas G

2016-01-01

Prostate cancer is the most prevalent cancer diagnosed in men in the United States besides skin cancer. Stereotactic body radiation therapy (SBRT; 6-15 Gy per fraction, up to 45 minutes per fraction, delivered in five fractions or less, over the course of approximately 2 weeks) is emerging as a popular treatment option for prostate cancer. The American Society for Radiation Oncology now recognizes SBRT for select low- and intermediate-risk prostate cancer patients. SBRT grew from the notion that high doses of radiation typical of brachytherapy could be delivered noninvasively using modern external-beam radiation therapy planning and delivery methods. SBRT is most commonly delivered using either a traditional gantry-mounted linear accelerator or a robotic arm-mounted linear accelerator. In this systematic review article, we compare and contrast the current clinical evidence supporting a gantry vs robotic arm SBRT for prostate cancer. The data for SBRT show encouraging and comparable results in terms of freedom from biochemical failure (>90% for low and intermediate risk at 5-7 years) and acute and late toxicity (6 MV). Finally, SBRT (particularly on a gantry) may also be more cost-effective than conventionally fractionated external-beam radiation therapy. Randomized controlled trials of SBRT using both technologies are underway.

Big Data and Comparative Effectiveness Research in Radiation Oncology: Synergy and Accelerated Discovery

Science.gov (United States)

Trifiletti, Daniel M.; Showalter, Timothy N.

2015-01-01

Several advances in large data set collection and processing have the potential to provide a wave of new insights and improvements in the use of radiation therapy for cancer treatment. The era of electronic health records, genomics, and improving information technology resources creates the opportunity to leverage these developments to create a learning healthcare system that can rapidly deliver informative clinical evidence. By merging concepts from comparative effectiveness research with the tools and analytic approaches of “big data,” it is hoped that this union will accelerate discovery, improve evidence for decision making, and increase the availability of highly relevant, personalized information. This combination offers the potential to provide data and analysis that can be leveraged for ultra-personalized medicine and high-quality, cutting-edge radiation therapy. PMID:26697409

Special conference of the American Association for Cancer Research on molecular imaging in cancer: linking biology, function, and clinical applications in vivo.

Science.gov (United States)

Luker, Gary D

2002-04-01

The AACR Special Conference on Molecular Imaging in Cancer: Linking Biology, Function, and Clinical Applications In Vivo, was held January 23-27, 2002, at the Contemporary Hotel, Walt Disney World, Orlando, FL. Co-Chairs David Piwnica-Worms, Patricia Price and Thomas Meade brought together researchers with diverse expertise in molecular biology, gene therapy, chemistry, engineering, pharmacology, and imaging to accelerate progress in developing and applying technologies for imaging specific cellular and molecular signals in living animals and humans. The format of the conference was the presentation of research that focused on basic and translational biology of cancer and current state-of-the-art techniques for molecular imaging in animal models and humans. This report summarizes the special conference on molecular imaging, highlighting the interfaces of molecular biology with animal models, instrumentation, chemistry, and pharmacology that are essential to convert the dreams and promise of molecular imaging into improved understanding, diagnosis, and management of cancer.

TH-AB-BRB-00: Research Opportunities with Digital Linear Accelerators

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-06-15

CA183390, NIH R01CA188300, Varian Medical Systems V. Yu, Varian Medical Systems, AAPM Summer Undergraduate Fellowship, NSF graduate fellowship S. Nill, Elekta AB. Cancer Research UK under Programme C33589/A19727, NIHR Biomedical Research Centre at The Royal Marsden and The Institute of Cancer Research.

TH-AB-BRB-00: Research Opportunities with Digital Linear Accelerators

International Nuclear Information System (INIS)

2016-01-01

CA183390, NIH R01CA188300, Varian Medical Systems V. Yu, Varian Medical Systems, AAPM Summer Undergraduate Fellowship, NSF graduate fellowship S. Nill, Elekta AB. Cancer Research UK under Programme C33589/A19727, NIHR Biomedical Research Centre at The Royal Marsden and The Institute of Cancer Research.

Hands-on Training Courses Using Research Reactors and Accelerators

International Nuclear Information System (INIS)

2014-01-01

The enhancement of nuclear science education and training in all Member States is of interest to the IAEA since many of these countries, particularly in the developing world, are building up and expanding their scientific and technological infrastructures. Unfortunately, most of these countries still lack sufficient numbers of well-educated and qualified nuclear specialists and technologists. This may arise from, amongst other things: a lack of candidates with sufficient educational background in nuclear science who would qualify to receive specialized training; a lack of institutions available for training nuclear science specialists; a lack of lecturers in nuclear related fields; and a lack of suitable educational and teaching materials. A related concern is the potential loss of valuable knowledge accumulated over many decades due to the ageing workforce. An imperative for Member States is to develop and offer suitable graduate and postgraduate academic programmes which combine study and project work so that students can attain a prerequisite level of knowledge, abilities and skills in their chosen subject area. In nearly all academic programmes, experimental work forms an essential and integral component of study to help students develop general and subject specific skills. Experimental laboratory courses and exercises can mean practical work in a conventional laboratory or an advanced facility with an operational particle accelerator or research reactor often accompanied by computer simulations and theoretical exercises. In this context, available or newly planned research reactors and particle accelerators should be seen as extremely important and indispensable components of nuclear science and technology curricula. Research reactors can demonstrate nuclear science and technology based on nuclear fission and the interaction of neutrons and photons with matter, while particle accelerators can demonstrate nuclear science and technology based on charged particle

Beam stability of cyclotron accelerator for therapy at National Cancer Center Hospital East

International Nuclear Information System (INIS)

Nishio, T.; Ogino, T.; Shinbo, M.; Ikeda, H.; Tachikawa, T.; Kumata, Y.

2000-01-01

In 1997, the proton-treatment facility that has the therapeutic AVF cyclotron accelerator (C235), is constructed at National Cancer Center Hospital East. The facility has 3-irradiation ports (rooms) that are 2-rotationg gantry ports and 1-horizontal fixed port. The C235 can accelerate proton to 235 MeV with the beam intensity of 300 nA. The external diameter is a very compact with about 4 m. The radio frequency is 106 MHz, the accelerating voltage is about 60 kV, and the harmonic number is 4. A beam stability of the C235 has an important relation with the uniformity of an irradiation field and is a very difficulty. The measured result indicated that the incident beam position must be into the 0.5-mmφ circle. (author)

Peralta Cancer Research Institute

International Nuclear Information System (INIS)

Anon.

1979-01-01

The investigators in the cell biology program at PCRI have pioneered in the development of techniques for culturing human epithelial cells. The cancer diagnosis program has been concerned with researching new techniques for early diagnosis of breast cancer in women. The cancer treatment program has been concerned with applying cell biology and biochemistry advances to improve cancer management

Technical development of high intensity proton accelerators in Japan Atomic Energy Research Institute (JAERI)

International Nuclear Information System (INIS)

Mizumoto, Motoharu

1995-01-01

Science and Technology Agency decided 'Options making extra gains of actinides and fission products (OMEGA)' and to promote the related researches. Also in JAERI, the research on the group separation method for separating transuranic elements, strontium and cesium from high level radioactive wastes has been carried out since the beginning of 1970s. Also the concept of the fast reactors using minor actinide mixture fuel is being established, and the accelerator annihilation treatment utilizing the nuclear spallation reaction by high energy protons has been examined. In this report, from the viewpoint of the application of accelerators to atomic energy field, the annihilation treatment method by the nuclear spallation reaction utilizing high intensity proton accelerators, the plan of the various engineering utilization of proton beam, and the development of accelerators in JAERI are described. The way of thinking on the annihilation treatment of radioactive waste, the system using fast neutrons, the way of thinking on the development of high intensity proton accelerator technology, the steps of the development, the research and development for constructing the basic technology accelerator, 2 MeV beam acceleration test, the basic technology accelerator utilization facility and so on are reported. (K.I.)

Status and future directions for advanced accelerator research - conventional and non-conventional collider concepts

International Nuclear Information System (INIS)

Siemann, R.H.

1997-01-01

The relationship between advanced accelerator research and future directions for particle physics is discussed. Comments are made about accelerator research trends in hadron colliders, muon colliders, and e + 3 - linear colliders

The Research of Vehicle Acceleration at Signalized Intersections

Directory of Open Access Journals (Sweden)

Vuk Bogdanović

2013-02-01

Full Text Available Vehicle acceleration is an important parameter used in planning various road elements, traffic signalization, geometric elements of an intersection, signal plans of traffic lights, etc. The knowledge of vehicle acceleration values is also necessary in using simulation softwares for more accurate analysis of the total situation at an intersection, on a road section or in a traffic network. In a lot of earlier studies, acceleration values were analysed and defined, mostly in optimal conditions for traffic functioning. However, values of almost all traffic flow parameters have been changed over time, due to changes in driving-dynamic vehicle characteristics, pneumatic tyres, material used for building road surface, etc. Besides, local environment influence and changes in drivers’ behaviour also significantly affect values of this parameter. According to HCM, it is advisable to perform local research for all values of the parameters recommended within the framework of this handbook, and to adapt their values to local conditions as well. The results of measuring the values of vehicles acceleration at signalized intersections in Novi Sad, Serbia, have been shown in this paper, using the procedure based on video recording processing.

Fostering Cooperation in Cancer Research

Science.gov (United States)

Thursday, June 25, 2015 Memorandum of Understanding (MoU) was signed between US National Cancer Institute and three agencies of the Indian government - the Department of Biotechnology, the Indian Council of Medical Research, and the Indian National Cancer Institute, a part of the All India Institute of Medical Sciences to foster cooperation in cancer research.

Translational Partnership Development Lead | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Frederick National Laboratory for Cancer Research (FNLCR) is a Federally Funded Research and Development Center operated by Leidos Biomedical Research, Inc on behalf of the National Cancer Institute (NCI). The staff of FNLCR support the NCI’s mission in the fight against cancer and HIV/AIDS. Currently we are seeking a Translational Partnership Development Lead (TPDL) who will work closely with the Office of Translational Resources (OTR) within the Office of the Director (OD) of NCI’s Center for Cancer Research (CCR) to facilitate the successful translation of CCR’s basic and preclinical research advances into new therapeutics and diagnostics. The TPDL with be strategically aligned within FNLCR’s Partnership Development Office (PDO), to maximally leverage the critical mass of expertise available within the PDO. CCR comprises the basic and clinical components of the NCI’s Intramural Research Program (IRP) and consists of ~230 basic and clinical Investigators located at either the NIH main campus in Bethesda or the NCI-Frederick campus. CCR Investigators are focused primarily on cancer and HIV/AIDS, with special emphasis on the most challenging and important high-risk/high-reward problems driving the fields. (See https://ccr.cancer.gov for a full delineation of CCR Investigators and their research activities.) The process of developing research findings into new clinical applications is high risk, complex, variable, and requires multiple areas of expertise seldom available within the confines of a single Investigator’s laboratory. To accelerate this process, OTR serves as a unifying force within CCR for all aspects of translational activities required to achieve success and maintain timely progress. A key aspect of OTR’s function is to develop and strengthen essential communications and collaborations within NIH, with extramural partners and with industry to bring together experts in chemistry, human subjects research

Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia.

Science.gov (United States)

Dunne, Richard F; Mustian, Karen M; Garcia, Jose M; Dale, William; Hayward, Reid; Roussel, Breton; Buschmann, Mary M; Caan, Bette J; Cole, Calvin L; Fleming, Fergal J; Chakkalakal, Joe V; Linehan, David C; Hezel, Aram F; Mohile, Supriya G

2017-12-01

Cancer cachexia remains understudied and there are no standard treatments available despite the publication of an international consensus definition and the completion of several large phase III intervention trials in the past 6 years. In September 2015, The University of Rochester Cancer Center NCORP Research Base led a Symposium on Cancer Cachexia and Sarcopenia with goals of reviewing the state of the science, identifying knowledge gaps, and formulating research priorities in cancer cachexia through active discussion and consensus. Research priorities that emerged from the discussion included the implementation of morphometrics into clinical decision making, establishing specific diagnostic criteria for the stages of cachexia, expanding patient selection in intervention trials, identifying clinically meaningful trial endpoints, and the investigation of exercise as an intervention for cancer cachexia. Standardizing how we define and measure cancer cachexia, targeting its complex biologic mechanisms, enrolling patients early in their disease course, and evaluating exercise, either alone or in combination, were proposed as initiatives that may ultimately result in the improved design of cancer cachexia therapeutic trials.

Senior Computational Scientist | Center for Cancer Research

Science.gov (United States)

The Basic Science Program (BSP) pursues independent, multidisciplinary research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR). The Cancer & Inflammation Program (CIP),

Report of the Study Group on Medical Uses of Accelerators

International Nuclear Information System (INIS)

1978-01-01

Medical uses of accelerators to raise the welfare of peoples are advancing rapidly due to the improvement of using technology. Under the situation, the Study Group on Medical Uses of Accelerators set up in the Science and Technology Agency has surveyed the status in Japan of radiation therapy of cancers and nuclear medicine with accelerators, and has studied on the future research and development in this field. The present report should contribute to the plans by the Government for the future. The results obtained by the study Group are described: the trends of medicine for the next ten years, especially the advances of cancer diagnosis and treatment and nuclear medicine; and medical radiation sources and the accelerators as their generators expected to be in practical utilization. As for the particles from accelerators used for medical purposes, there are fast neutrons, protons, helium particles, charged heavy particles, and π-mesons. For diagnosis and treatment, the radiation sources must be chosen according to the purposes, and their combination becomes necessary. (Mori, K.)

The CARE project (Coordinated Accelerator Research in Europe)

International Nuclear Information System (INIS)

Napoly, Olivier

2006-01-01

CARE, an ambitious and coordinated project of accelerator research and developments oriented towards High Energy Physics projects, has been launched in January 2004 by the main European laboratories and the European Commission with the 6th Framework Programme. This project aims at improving existing infrastructures dedicated to future projects such as linear colliders, upgrades of hadron colliders and high intensity proton drivers An important part of this programme is devoted to advancing the performance of the superconducting technology, both in the fields of RF cavities for electron and proton acceleration and of high field magnets, as well as to developing high intensity electron and proton injectors. We describe the plans of the four main Joint Research Activities and report on the results and progress obtained so far. The CARE project also includes three adjacent Networking Activities whose main goal is to organize a forum of discussions and to provide the strategic plans in the fields of the Linear Collider, intense Neutrino Beams, and future Hadron Colliders

Research of Virtual Accelerator Control System

Institute of Scientific and Technical Information of China (English)

DongJinmei; YuanYoujin; ZhengJianhua

2003-01-01

A Virtual Accelerator is a computer process which simulates behavior of beam in an accelerator and responds to the accelerator control program under development in a same way as an actual accelerator. To realize Virtual Accelerator, control system should provide the same program interface to top layer Application Control Program, it can make 'Real Accelerator' and 'Virtual Accelerator'use the same GUI, so control system should have a layer to hide hardware details, Application Control Program access control devices through logical name but not through coded hardware address. Without this layer, it is difficult to develop application program which can access both 'Virtual' and 'Real' Accelerators using same program interfaces. For this reason, we can create CSR Runtime Database which allows application program to access hardware devices and data on a simulation process in a unified way. A device 'is represented as a collection of records in CSR Runtime Database. A control program on host computer can access devices in the system only through names of record fields, called channel.

Electron string ion sources for carbon ion cancer therapy accelerators

Science.gov (United States)

Boytsov, A. Yu.; Donets, D. E.; Donets, E. D.; Donets, E. E.; Katagiri, K.; Noda, K.; Ponkin, D. O.; Ramzdorf, A. Yu.; Salnikov, V. V.; Shutov, V. B.

2015-08-01

The type of the Electron String Ion Sources (ESIS) is considered to be the appropriate one to produce pulsed C4+ and C6+ ion beams for cancer therapy accelerators. In fact, the new test ESIS Krion-6T already now provides more than 1010 C4+ ions per pulse and about 5 × 109 C6+ ions per pulse. Such ion sources could be suitable to apply at synchrotrons. It has also been found that Krion-6T can provide more than 1011 C6+ ions per second at the 100 Hz repetition rate, and the repetition rate can be increased at the same or larger ion output per second. This makes ESIS applicable at cyclotrons as well. ESIS can be also a suitable type of ion source to produce the 11C radioactive ion beams. A specialized cryogenic cell was experimentally tested at the Krion-2M ESIS for pulse injection of gaseous species into the electron string. It has been shown in experiments with stable methane that the total conversion efficiency of methane molecules to C4+ ions reached 5%÷10%. For cancer therapy with simultaneous irradiation and precise dose control (positron emission tomography) by means of 11C, transporting to the tumor with the primary accelerated 11C4+ beam, this efficiency is preliminarily considered to be large enough to produce the 11C4+ beam from radioactive methane and to inject this beam into synchrotrons.

Engineering research and development for the Elise Heavy Ion Induction Accelerator

International Nuclear Information System (INIS)

Reginato, L.; Peters, C.

1995-08-01

The Fusion Energy Research engineering team has been conducting Research and Development Associated with the Construction (RDAC) of the Elise accelerator since the approval of Key Decision one (KD1 is start of construction). The engineering design effort has worked in close cooperation with the physics design staff to achieve all parameters of the Elise accelerator. The design included the 2 MV injector, matching section, combiner, induction cells, electric/magnetic quadrupoles, alignment system and controls. All major designs and some hardware testing will be discussed

Engineering research and development for the Elise heavy ion induction accelerator

International Nuclear Information System (INIS)

Reginato, L.; Peters, C.

1996-01-01

The fusion energy research engineering team has been conducting research and development associated with the construction of the Elise accelerator since the approval of key decision 1 (this is the start of construction). The engineering design effort has worked in close cooperation with the physics design staff to achieve all parameters of the Elise accelerator. The design included the 2 MV injector, matching section, combiner, induction cells, electric-magnetic quadrupoles, alignment system and controls. All major designs and some hardware testing will be discussed. (orig.)

Accelerator and Fusion Research Division: 1984 summary of activities

International Nuclear Information System (INIS)

1985-05-01

During fiscal 1984, major programmatic activities in AFRD continued in each of five areas: accelerator operations, highlighted by the work of nuclear science users, who produced clear evidence for the formation of compressed nuclear matter during heavy-ion collisions; high-energy physics, increasingly dominated by our participation in the design of the Superconducting Super Collider; heavy-ion fusion accelerator research, which focused on the design of a four-beam experiment as a first step toward assessing the promise of heavy-ion inertial-confinement fusion; and research at the Center for X-Ray Optics, which completed its first year of broadly based activities aimed at the exploitation of x-ray and ultraviolet radiation. At the same time, exploratory studies were under way, aimed at investigating major new programs for the division. During the past year, for example, we took a preliminary look at how we could use the Bevatron as an injector for a pair of colliding-beam rings that might provide the first glimpse of a hitherto unobserved state of matter called the quark-gluon plasma. Together with Livermore scientists, we also conducted pioneering high-gain free-electron laser (FEL) experiments and proposed a new FEL-based scheme (called the two-beam accelerator) for accelerating electrons to very high energies. And we began work on the design of the Coherent XUV Facility (CXF), an advanced electron storage ring for the production of intense coherent radiation from either undulators or free-electron lasers

Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.

Science.gov (United States)

Durso, Danielle Fernandes; Bacalini, Maria Giulia; Sala, Claudia; Pirazzini, Chiara; Marasco, Elena; Bonafé, Massimiliano; do Valle, Ítalo Faria; Gentilini, Davide; Castellani, Gastone; Faria, Ana Maria Caetano; Franceschi, Claudio; Garagnani, Paolo; Nardini, Christine

2017-04-04

Changes in blood epigenetic age have been associated with several pathological conditions and have recently been described to anticipate cancer development. In this work, we analyze a publicly available leukocytes methylation dataset to evaluate the relation between DNA methylation age and the prospective development of specific types of cancer. We calculated DNA methylation age acceleration using five state-of-the-art estimators (three multi-site: Horvath, Hannum, Weidner; and two CpG specific: ELOV2 and FHL2) in a cohort including 845 subjects from the EPIC-Italy project and we compared 424 samples that remained cancer-free over the approximately ten years of follow-up with 235 and 166 subjects who developed breast and colorectal cancer, respectively. We show that the epigenetic age estimated from blood DNA methylation data is statistically significantly associated to future breast and male colorectal cancer development. These results are corroborated by survival analysis that shows significant association between age acceleration and cancer incidence suggesting that the chance of developing age-related diseases may be predicted by circulating epigenetic markers, with a dependence upon tumor type, sex and age estimator. These are encouraging results towards the non-invasive and perspective usage of epigenetic biomarkers.

Research Associate | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Basic Science Program (BSP) pursues independent, multidisciplinary research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR). KEY ROLES/RESPONSIBILITIES - Research Associate III Dr. Zbigniew Dauter is the head investigator of the Synchrotron Radiation Research Section (SRRS) of CCR’s Macromolecular Crystallography Laboratory. The Synchrotron Radiation Research Section is located at Argonne National Laboratory, Argonne, Illinois; this is the site of the largest U.S. synchrotron facility. The SRRS uses X-ray diffraction technique to solve crystal structures of various proteins and nucleic acids of biological and medical relevance. The section is also specializing in analyzing crystal structures at extremely high resolution and accuracy and in developing methods of effective diffraction data collection and in using weak anomalous dispersion effects to solve structures of macromolecules. The areas of expertise are: Structural and molecular biology Macromolecular crystallography Diffraction data collection Dr. Dauter requires research support in these areas, and the individual will engage in the purification and preparation of samples, crystallize proteins using various techniques, and derivatize them with heavy atoms/anomalous scatterers, and establish conditions for cryogenic freezing. Individual will also participate in diffraction data collection at the Advanced Photon Source. In addition, the candidate will perform spectroscopic and chromatographic analyses of protein and nucleic acid samples in the context of their purity, oligomeric state and photophysical properties.

Research on cancer diagnosis in Malaysia: current status.

Science.gov (United States)

Looi, L M; Zubaidah, Z; Cheah, P L; Cheong, S K; Gudum, H R; Iekhsan, O; Ikram, S I; Jamal, R; Mak, J W; Othman, N H; Puteri, J N; Rosline, H; Sabariah, A R; Seow, H F; Sharifah, N A

2004-06-01

Cancer is a major morbidity and mortality concern in Malaysia. Based on National Cancer Registry data, the Malaysian population is estimated to bear a cancer burden of about 40,000 new cases per year, and a cumulative lifetime risk of about 1:4. Cancer research in Malaysia has to consider needs relevant to our population, and resources constraints. Hence, funding bodies prioritise cancers of high prevalence, unique to our community and posing specific clinical problems. Cancer diagnosis is crucial to cancer management. While cancer diagnosis research largely aims at improvements in diagnostic information towards more appropriate therapy, it also impacts upon policy development and other areas of cancer management. The scope of cancer diagnosis upon which this paper is based, and their possible impact on other R&D areas, has been broadly categorized into: (1) identification of aetiological agents and their linkages to the development of precancer and cancer (impact on policy development, cancer prevention and treatment), (2) cancer biology and pathogenesis (impact on cancer prevention, treatment strategies and product development), (3) improvements in accuracy, sensitivity and specificity in cancer detection, monitoring and classification (impact on technology development) and (4) prognostic and predictive parameters (impact on treatment strategies). This paper is based on data collected by the Working Group on Cancer Diagnosis Research for the First National Conference on Cancer Research Coordination in April 2004. Data was collated from the databases of Institutions/Universities where the authors are employed, the Ministry of Science, Technology and Innovation (MOSTI) and targeted survey feedback from key cancer researchers. Under the 7th Malaysia Plan, 76 cancer projects were funded through the Intensified Research in Priority Areas (IRPA) scheme of MOSTI, amounting to almost RM15 million of grant money. 47(61.8%) of these projects were substantially in cancer

Accelerator R and D: Research for Science - Science for Society

International Nuclear Information System (INIS)

Holtkamp, N.R.; Biedron, S.; Milton, S.V.; Boeh, L.; Clayton, J.E.; Zdasiuk, G.; Gourlay, S.A.; Zisman, M.S.; Hamm, R.W.; Henderson, S.; Hoffstaetter, G.H.; Merminga, L.; Ozaki, S.; Pilat, F.C.; White, M.

2012-01-01

In September 2011 the US Senate Appropriations Committee requested a ten-year strategic plan from the Department of Energy (DOE) that would describe how accelerator R and D today could advance applications directly relevant to society. Based on the 2009 workshop 'Accelerators for America's Future' an assessment was made on how accelerator technology developed by the nation's laboratories and universities could directly translate into a competitive strength for industrial partners and a variety of government agencies in the research, defense and national security sectors. The Office of High Energy Physics, traditionally the steward for advanced accelerator R and D within DOE, commissioned a task force under its auspices to generate and compile ideas on how best to implement strategies that would help fulfill the needs of industry and other agencies, while maintaining focus on its core mission of fundamental science investigation.

Accelerator mass spectrometry in biomedical research

International Nuclear Information System (INIS)

Vogel, J.S.; Turteltaub, K.W.

1993-01-01

Biological effects occur in natural systems at chemical concentrations of parts per billion (1:10 9 ) or less. Affected biomolecules may be separable in only milligram or microgram quantities. Quantification at attomole sensitivity is needed to study these interactions. AMS measures isotope concentrations to parts per 10 13--15 on milligram-sized samples and is ideal for quantifying long-lived radioisotopic labels that are commonly used to trace biochemical pathways in natural systems. 14 C-AMS has now been coupled to a variety of organic separation and definition technologies. The primary research investigates pharmacokinetics and genotoxicities of toxins and drugs at very low doses. Human subject research using AMS includes nutrition, toxicity and elemental balance studies. 3 H, 41 Ca and 26 Al are also traced by AMS for fundamental biochemical kinetic research. Expansion of biomedical AMS awaits further development of biochemical and accelerator technologies designed specifically for these applications

Present status of tandem accelerator in Japan Atomic Energy Research Institute

Energy Technology Data Exchange (ETDEWEB)

Yoshida, Tadashi; Kanda, Susumu; Takeuchi, Suehiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1996-12-01

The tandem accelerator in Japan Atomic Energy Research Institute was made by NEC in USA. Since it is the accelerator of turning-up structure, it has large magnet at the high voltage terminal, and supplies electric power by driving a generator with large diameter shaft. The control is carried out by CAMUCK, and the electronic circuit is protected from the surging arising due to discharge. Since the experiment on full scale was begun, 14 years have elapsed, and at present, it became a very stable accelerator. As to the operation mode, the acceleration voltage is limited to below 17 MV. The operation voltage and the state of operation are shown. Recently, the troubles of chains originating in oil have occurred. The adjustment of the tandem accelerator requires more than one month. The adjustment is mainly related to the chains and shafts, and this is explained. The ion source used for the tandem accelerator at present is the negative ion source made by NEC. The installation of an ECR ion source is planned. The utilization of the tandem accelerator system is reported. (K.I.)

50 Years of the Radiological Research Accelerator Facility (RARAF)

OpenAIRE

Marino, Stephen A.

2017-01-01

The Radiological Research Accelerator Facility (RARAF) is in its 50th year of operation. It was commissioned on April 1, 1967 as a collaboration between the Radiological Research Laboratory (RRL) of Columbia University, and members of the Medical Research Center of Brookhaven National Laboratory (BNL). It was initially funded as a user facility for radiobiology and radiological physics, concentrating on monoenergetic neutrons. Facilities for irradiation with MeV light charged particles were d...

Dr. Ted Trimble: Why I Do Cancer Research

Science.gov (United States)

In a video, Dr. Ted Trimble talks about the importance of cancer research. World Cancer Research Day commemorates the important role research and cancer researchers play in reducing the global burden of cancer.

Research Summaries: The 11th Biennial Rivkin Center Ovarian Cancer Research Symposium.

Science.gov (United States)

Armstrong, Deborah K

2017-11-01

In September 2016, the 11th biennial ovarian cancer research symposium was presented by the Rivkin Center for Ovarian Cancer and the American Association for Cancer Research. The 2016 symposium focused on 4 broad areas of research: Mechanisms of Initiation and Progression of Ovarian Cancer, Tumor Microenvironment and Models of Ovarian Cancer, Detection and Prevention of Ovarian Cancer, and Novel Therapeutics for Ovarian Cancer. The presentations and abstracts from each of these areas are reviewed in this supplement to the International Journal of Gynecologic Oncology.

Latest discoveries and trends in translational cancer research: highlights of the 2008 Annual Meeting of the American Association for Cancer Research.

Science.gov (United States)

Cho, William C S

2008-08-01

The Annual Meeting of the American Association for Cancer Research (AACR) is the world's largest and most comprehensive gathering of cancer researchers. At the 2008 AACR Annual Meeting, innovative research approaches, novel technologies, potentially life-saving therapies in the pipeline, late-breaking clinical trial findings, and new approaches to cancer prevention were presented by top scientists. Reflecting the global state of cancer research with an eye toward future trends, several areas of great science and discovery in the cancer field were shared in this report, which include cancer biomarkers, the role of microRNAs in cancer research, cancer stem cells, tumor microenvironment, targeted therapy, and cancer prevention. This article presents an overview of hot topics discussed at the 2008 AACR Annual Meeting and recapitulates some scientific sessions geared toward new technologies, recent progress, and current challenges reported by cancer researchers. For those who did not attend the meeting, this report may serve as a highlight of this important international cancer research meeting.

Cancer research and radiotherapy

International Nuclear Information System (INIS)

Matsuzawa, Taiju

1978-01-01

An actual condition of cancer, and the basis and a future view of radiotherapy were described by adding generally established biological and biochemical knowledge to the author's research. It was described that the relapse of cancer after irradiation was induced from outside of cancerous mass, and the nature of relapsed cancerous cells group was also stated. The histological structure of cancer from a view of cell movement and radioresistant cancerous cells group were described. The differentiation of cancerous cells were described, and a study of inhibition of cancer by redifferentiation was considered. It is important to grasp characteristics and a limit of radiotherapy for cancer, to systematize and materialize reasonable therapy which uses drug and immunotherapy together with surgery, and to use radiotherapy reasonably together with redifferentiation therapy of cancerous cells by extracting characteristics and a limit of radiationtherapy from an actual condition of cancer. (Serizawa, K.)

Translational Research 2.0: a framework for accelerating collaborative discovery.

Science.gov (United States)

Asakiewicz, Chris

2014-05-01

The world wide web has revolutionized the conduct of global, cross-disciplinary research. In the life sciences, interdisciplinary approaches to problem solving and collaboration are becoming increasingly important in facilitating knowledge discovery and integration. Web 2.0 technologies promise to have a profound impact - enabling reproducibility, aiding in discovery, and accelerating and transforming medical and healthcare research across the healthcare ecosystem. However, knowledge integration and discovery require a consistent foundation upon which to operate. A foundation should be capable of addressing some of the critical issues associated with how research is conducted within the ecosystem today and how it should be conducted for the future. This article will discuss a framework for enhancing collaborative knowledge discovery across the medical and healthcare research ecosystem. A framework that could serve as a foundation upon which ecosystem stakeholders can enhance the way data, information and knowledge is created, shared and used to accelerate the translation of knowledge from one area of the ecosystem to another.

Annual report of Department of Research Reactor and Tandem Accelerator, JFY2012. Operation, utilization and technical development of JRR-3, JRR-4, NSRR, Tandem Accelerator and RI Production Facility

International Nuclear Information System (INIS)

Murayama, Yoji; Ishii, Tetsuro; Nakamura, Kiyoshi; Uno, Yuki; Ishikuro, Yasuhiro; Kawashima, Kazuhito; Ishizaki, Nobuhiro; Matsumura, Taichi; Nagahori, Kazuhisa; Odauchi, Shouji; Maruo, Takeshi

2014-03-01

The Department of Research Reactor and Tandem Accelerator is in charge of the operation, utilization and technical development of JRR-3(Japan Research Reactor No.3), JRR-4(Japan Research Reactor No.4), NSRR(Nuclear Safety Research Reactor), Tandem Accelerator and RI Production Facility. This annual report describes a summary of activities of services and technical developments carried out in the period between April 1, 2012 and March 31, 2013. The activities were categorized into five service/development fields: (1) Operation and maintenance of research reactors and tandem accelerator, (2) Utilization of research reactors and tandem accelerator, (3) Upgrading of utilization techniques of research reactors and tandem accelerator, (4) Safety administration for department of research reactor and tandem accelerator, (5) International cooperation. Also contained are lists of publications, meetings, granted permissions on laws and regulations concerning atomic energy, number of staff members dispatched to Fukushima for the technical assistance, outcomes in service and technical developments and so on. (author)

Setting Research Priorities for Kidney Cancer.

Science.gov (United States)

Jones, Jennifer M; Bhatt, Jaimin; Avery, Jonathan; Laupacis, Andreas; Cowan, Katherine; Basappa, Naveen S; Basiuk, Joan; Canil, Christina; Al-Asaaed, Sohaib; Heng, Daniel Y C; Wood, Lori; Stacey, Dawn; Kollmannsberger, Christian; Jewett, Michael A S

2017-12-01

Defining disease-specific research priorities in cancer can facilitate better allocation of limited resources. Involving patients and caregivers as well as expert clinicians in this process is of value. We undertook this approach for kidney cancer as an example. The Kidney Cancer Research Network of Canada sponsored a collaborative consensus-based priority-setting partnership that identified ten research priorities in the management of kidney cancer. These are discussed in the context of current initiatives and gaps in knowledge. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Electron Microscopist | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR). The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and genetics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR). CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. KEY ROLES/RESPONSIBILITIES - THIS POSITION IS CONTINGENT UPON FUNDING APPROVAL The Electron Microscopist will: Operate ultramicrotomes (Leica) and other instrumentation related to the preparation of embedded samples for EM (TEM and SEM) Operate TEM microscopes, (specifically Hitachi, FEI T20 and FEI T12) as well as SEM microscopes (Hitachi); task will include loading samples, screening, and performing data collection for a variety of samples: from cells to proteins Manage maintenance for the TEM and SEM microscopes Provide technical advice to investigators on sample preparation and data collection

Accelerator and Fusion Research Division. Annual report, October 1978-September 1979

International Nuclear Information System (INIS)

1980-03-01

Topics covered include: Super HILAC and Bevalac operations; high intensity uranium beams line item; advanced high charge state ion source; 184-inch synchrocyclotron; VENUS project; positron-electron project; high field superconducting accelerator magnets; beam cooling; accelerator theory; induction linac drivers; RF linacs and storage rings; theory; neutral beam systems development; experimental atomic physics; neutral beam plasma research; plasma theory; and the Tormac project

Accelerating Corporate Research in the Development, Application and Deployment of Human Language Technologies

National Research Council Canada - National Science Library

Ferrucci, David; Lally, Adam

2003-01-01

... accelerate scientific advance. Furthermore, the ability to reuse and combine results through a common architecture and a robust software framework would accelerate the transfer of research results in HLT into IBM's product platforms...

Analysis of conditions to safety and radiological protection of Brazilian research particle accelerators facilities

International Nuclear Information System (INIS)

Lourenco, Manuel Jacinto Martins

2010-01-01

Eleven institutions of education and research in Brazil use particle accelerators, which fulfill different functions and activities. Currently, these institutions employ a total of fifteen accelerators. In this paper, the object of study is the radiological protection of occupationally exposed individuals, the general public and the radiation safety of particle accelerators. Research facilities with accelerators are classified in categories I and II according to the International Atomic Energy Agency or groups IX and X in accordance with the Brazilian National Commission of Nuclear Energy. Of the 15 accelerators in use for research in Brazil, four belong to category I or group X and eleven belong to category II or group IX. The methodology presented and developed in this work was made through the inspection and assessment of safety and radiological protection of thirteen particle accelerators facilities, and its main purpose was to promote safer use of this practice by following established guidelines for safety and radiological protection. The results presented in this work showed the need to create a program, in our country, for the control of safety and radiological protection of this ionizing radiation practice. (author)

Electron string ion sources for carbon ion cancer therapy accelerators

Energy Technology Data Exchange (ETDEWEB)

Boytsov, A. Yu.; Donets, D. E.; Donets, E. D.; Donets, E. E.; Ponkin, D. O.; Ramzdorf, A. Yu.; Salnikov, V. V.; Shutov, V. B. [Joint Institute for Nuclear Research, Dubna 141980 (Russian Federation); Katagiri, K.; Noda, K. [National Institute of Radiological Science, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

2015-08-15

The type of the Electron String Ion Sources (ESIS) is considered to be the appropriate one to produce pulsed C{sup 4+} and C{sup 6+} ion beams for cancer therapy accelerators. In fact, the new test ESIS Krion-6T already now provides more than 10{sup 10} C{sup 4+} ions per pulse and about 5 × 10{sup 9} C{sup 6+} ions per pulse. Such ion sources could be suitable to apply at synchrotrons. It has also been found that Krion-6T can provide more than 10{sup 11} C{sup 6+} ions per second at the 100 Hz repetition rate, and the repetition rate can be increased at the same or larger ion output per second. This makes ESIS applicable at cyclotrons as well. ESIS can be also a suitable type of ion source to produce the {sup 11}C radioactive ion beams. A specialized cryogenic cell was experimentally tested at the Krion-2M ESIS for pulse injection of gaseous species into the electron string. It has been shown in experiments with stable methane that the total conversion efficiency of methane molecules to C{sup 4+} ions reached 5%÷10%. For cancer therapy with simultaneous irradiation and precise dose control (positron emission tomography) by means of {sup 11}C, transporting to the tumor with the primary accelerated {sup 11}C{sup 4+} beam, this efficiency is preliminarily considered to be large enough to produce the {sup 11}C{sup 4+} beam from radioactive methane and to inject this beam into synchrotrons.

Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

Science.gov (United States)

The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health are offering a one week educational opportunity in "Nutrition and Cancer Prevention Research" for individuals with a sustained commitment to nutrition

Accelerator-based research facility of UGC as an inter-university centre

International Nuclear Information System (INIS)

Mehta, G.K.

1994-01-01

A 15-UD Pelletron has been operating as a users facility from July 1991. It is being utilised by a large number of universities and other institutions for research in basic nuclear physics, materials science, atomic physics, radiobiology and radiation chemistry. There is an on-going programme for augmenting the accelerator facilities by injecting Pelletron beams into superconducting linear accelerator modules. Superconducting niobium resonators are being developed at Argonne National Laboratory as a joint collaborative effort. All other things such as cryostat, rf-instrumentation, cryogene distribution system, computer control etc. are being done indigenously. Research possibilities are described. (author). 6 refs., 4 figs

Research on Fast Track Surgery Application in Lung Cancer Surgery

Directory of Open Access Journals (Sweden)

Kaiyun YANG

2010-02-01

Full Text Available Background and objective Fast track surgery (FTS is a systematical method to accelerate the recovery of surgical patients by reducing the physical and mental trauma stress of them. The research is to investigate the feasibility of FTS application in lung cancer surgery. Methods A total of 80 cases of lung cancer patients with single leaf lobotomy resection were randomized into two groups. While the experimental group was treated with the conception of FTS, and the control group was treated with the traditional methods. The incident rate of post-operation pain degrees, telecasts, pleural effusion, the post-operation time stay in hospital time and the total cost during hospitalization in two groups were compared respectively. Results In FTS group: the VAS score of post-operation pain at 1 h, 6 h, 12 h, 24 h and 48 h all significantly decreased compared to the traditional therapy group. The incidence rate of telecast was 10.53%. The incidence rate of pleural effusion was 26.31%. The length of stay after operation was (4±1 d and the total cost was RMB 15 600±7 600. In the control group, the above values were 77.78%, 33.33%, 22.22%, (9±1 d, RMB 23 600±5 400, respectively. The post operation pain (VAS method of FTS group was remarkablely below the control group. There has significant difference of the incident rate of telecasts, stay time in hospital and the total cast in two groups (P < 0.05. No significant difference was observed in the incident rate of pleural effusion. Conclusion The new methods of FTS can apparently accelerates recovery after lung cancer resection, reduces complications, shorten timestay in hospital and cut down the total cost.

Immunotherapy: A breakthrough in cancer research

Directory of Open Access Journals (Sweden)

Editorial Office

2016-12-01

a mixed population. The clinical benefit of the fixed dose of pembrolizumab in the first and second line treatment of recurrent/metastatic head and neck cancer is being evaluated head-to-head with standard of care chemotherapy in phase 3 trials around the world, including Asia Pacific.” Meanwhile, another research paper on immunotherapy presented at the ESMO Asia 2016 was by Dr. Herbert Loong, Clinical Assistant Professor at the Department of Clinical Oncology of the Chinese University of Hong Kong, who discussed about the cost-effectiveness of immunotherapy with pembrolizumab for advanced melanoma patients in Hong Kong. Dr. Loong said, “We have determined that whilst pembrolizumab is expensive, the increase in quality adjusted life years (QALYs compared with standard cytotoxic chemotherapy, and even so with ipilimumab, qualifies it as a cost-effective approach.” Commenting on the results of the research by Dr. Loong and his colleagues, Dr. Mark Tang – a senior consultant dermatologist said, “Given the high costs of these new treatment options, cost effectiveness studies such as this one are timely and useful as further evidence for the use of pembrolizumab in the treatment of advanced melanoma. This is particularly important in an Asian context where, although rare, acral melanoma has unfortunately been known to present late advanced disease.” Taking all these exciting discoveries into account, a good number of studies have repeatedly shown that progress in cancer immunotherapy has accelerated and resulted in the development of several effective and promising therapies for multiple forms of cancer. At this critical juncture, oncological organizations such as ESMO provide an important knowledge transfer platform for the sharing of expertise and interaction between regional and international experts in the area of onco-immunology. Moving forward, immunotherapy and targeted medicine are expected to remain in the spotlight and will be an indispensable

A randomized study of accelerated fractionation radiotherapy with and without mitomycin C in the treatment of locally advanced head and neck cancer

DEFF Research Database (Denmark)

Ezzat, M.; Shouman, T.; Zaza, K.

2005-01-01

Objectives: This single-institution study evaluates the feasibility of accelerated fractionation radiotherapy (AF) with and without mitomycin C (MMC) in the treatment of locally advanced head and neck cancer. Patients and Methods: Between May 1998 and October 2001, sixty patients with locally...... advanced stage III and IV of head and neck cancer were randomized into three treatment arms: (1) conventional fractionation radiotherapy (CF) (5 fractions per week); (2) accelerated fractionation radiotherapy (AF) (6 fractions per week); and (3) AF plus Mitomycin C (MMC). Results: The 2-year overall....... Key Words: Head and Neck cancer , Radiotherapy , Altered fractionation , Mitomycin C....

The radiological research accelerator facility. Progress report, December 1, 1995--November 30, 1996

International Nuclear Information System (INIS)

Hall, E.J.; Marino, S.A.

1996-08-01

The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) - formerly the Radiological Research Laboratory (RRL) - of Columbia University, and its operation is supported as a National Facility by the U.S. Department of Energy (DOE). As such, RARAF is available to all potential users on an equal basis and scientists outside the CRR are encouraged to submit proposals for experiments at RARAF. The operation of the Van de Graaff is supported by the DOE, but the research projects themselves must be supported separately. RARAF was conceived in the mid-1960s by Drs. Victor P. Bond of Brookhaven National Laboratory (BNL) and Harald H. Rossi of Columbia University as a research resource dedicated to radiobiology and radiological physics and was officially established on January 1, 1967. The RARAF Van de Graaff accelerator originally served as the injector for the Cosmotron, a 2-GeV accelerator operated at BNL in the 1950s and early 1960s. The immediate aim was to provide a source of monoenergetic neutrons for studies in radiation biology, dosimetry, and microdosimetry. In other major projects the energetic ions produced were utilized directly. RARAF was located at BNL from 1967 until 1980, when it was dismantled and moved to the Nevis Laboratories of Columbia University, where it was then reassembled and returned to operation. This report contains the following information on RARAF: RARAF user's guide; scientific advisory committee; research using RARAF; accelerator utilization and operation; and development of the facilities

Heavy-ion accelerator research for inertial fusion

International Nuclear Information System (INIS)

1987-08-01

Thermonuclear fusion offers a most attractive long-term solution to the problem of future energy supplies: The fuel is virtually inexhaustible and the fusion reaction is notably free of long-lived radioactive by-products. Also, because the fuel is in the form of a plasma, there is no solid fuel core that could melt down. The DOE supports two major fusion research programs to exploit these virtues, one based on magnetic confinement and a second on inertial confinement. One part of the program aimed at inertial fusion is known as Heavy Ion Fusion Accelerator Research, or HIFAR. In this booklet, the aim is to place this effort in the context of fusion research generally, to review the brief history of heavy-ion fusion, and to describe the current status of the HIFAR program

Architecture and Civil Design Status of the Proton Accelerator Research Center in PEFP

International Nuclear Information System (INIS)

Nam, J. M.; Kim, J. Y.; Mun, K. J.; Jeon, G. P.; Cho, J. S.; Lee, S. K.; Min, Y. S.; Joo, H. G.

2009-01-01

PEFP (Proton Engineering Frontier Project) is scheduled to administrate the conventional facilities design with Gyeongju and complement its unfit points. When construction work starts according to the construction schedule, a field work office will be installed to supervise the Proton Accelerator Conventional Facilities Construction. In this paper, we describe the geological investigation procedure for the construction of the proton accelerator conventional facilities of PEFP. By the geological investigation, data for the reasonable and economic construction work, such as stratum structure and geotechnical characteristics. In Site Plot Plan for PEFP, we classified center as 2 groups such as main facilities and support facilities. We also designed access road of the Proton Accelerator Research Center of PEFP. In architectural design for PEFP, we described the design procedure of the buildings and landscape architectures of the Proton Accelerator Research Center

Laser acceleration

Science.gov (United States)

Tajima, T.; Nakajima, K.; Mourou, G.

2017-02-01

The fundamental idea of Laser Wakefield Acceleration (LWFA) is reviewed. An ultrafast intense laser pulse drives coherent wakefield with a relativistic amplitude robustly supported by the plasma. While the large amplitude of wakefields involves collective resonant oscillations of the eigenmode of the entire plasma electrons, the wake phase velocity ˜ c and ultrafastness of the laser pulse introduce the wake stability and rigidity. A large number of worldwide experiments show a rapid progress of this concept realization toward both the high-energy accelerator prospect and broad applications. The strong interest in this has been spurring and stimulating novel laser technologies, including the Chirped Pulse Amplification, the Thin Film Compression, the Coherent Amplification Network, and the Relativistic Mirror Compression. These in turn have created a conglomerate of novel science and technology with LWFA to form a new genre of high field science with many parameters of merit in this field increasing exponentially lately. This science has triggered a number of worldwide research centers and initiatives. Associated physics of ion acceleration, X-ray generation, and astrophysical processes of ultrahigh energy cosmic rays are reviewed. Applications such as X-ray free electron laser, cancer therapy, and radioisotope production etc. are considered. A new avenue of LWFA using nanomaterials is also emerging.

Laser acceleration

International Nuclear Information System (INIS)

Tajima, T.; Nakajima, K.; Mourou, G.

2017-01-01

The fundamental idea of LaserWakefield Acceleration (LWFA) is reviewed. An ultrafast intense laser pulse drives coherent wakefield with a relativistic amplitude robustly supported by the plasma. While the large amplitude of wake fields involves collective resonant oscillations of the eigenmode of the entire plasma electrons, the wake phase velocity ∼ c and ultra fastness of the laser pulse introduce the wake stability and rigidity. A large number of worldwide experiments show a rapid progress of this concept realization toward both the high-energy accelerator prospect and broad applications. The strong interest in this has been spurring and stimulating novel laser technologies, including the Chirped Pulse Amplification, the Thin Film Compression, the Coherent Amplification Network, and the Relativistic Mirror Compression. These in turn have created a conglomerate of novel science and technology with LWFA to form a new genre of high field science with many parameters of merit in this field increasing exponentially lately. This science has triggered a number of worldwide research centers and initiatives. Associated physics of ion acceleration, X-ray generation, and astrophysical processes of ultrahigh energy cosmic rays are reviewed. Applications such as X-ray free electron laser, cancer therapy, and radioisotope production etc. are considered. A new avenue of LWFA using nano materials is also emerging.

NIST Accelerator Facilities And Programs In Support Of Industrial Radiation Research

International Nuclear Information System (INIS)

Bateman, F.B.; Desrosiers, M.F.; Hudson, L.T.; Coursey, B.M.; Bergstrom, P.M. Jr.; Seltzer, S.M.

2003-01-01

NIST's Ionizing Radiation Division maintains and operates three electron accelerators used in a number of applications including waste treatment and sterilization, radiation hardness testing, detector calibrations and materials modification studies. These facilities serve a large number of governmental, academic and industrial users as well as an active intramural research program. They include a 500 kV cascaded-rectifier accelerator, a 2.5 MV electron Van de Graaff accelerator and a 7 to 32 MeV electron linac, supplying beams ranging in energy from a few keV up to 32 MeV. In response to the recent anthrax incident, NIST along with the US Postal Service and the Armed Forces Radiobiology Research Institute (AFRRI) are working to develop protocols and testing procedures for the USPS mail sanitization program. NIST facilities and personnel are being employed in a series of quality-assurance measurements for both electron- and photon-beam sanitization. These include computational modeling, dose verification and VOC (volatile organic compounds) testing using megavoltage electron and photon sources

Harnessing the crowd to accelerate molecular medicine research.

Science.gov (United States)

Smith, Robert J; Merchant, Raina M

2015-07-01

Crowdsourcing presents a novel approach to solving complex problems within molecular medicine. By leveraging the expertise of fellow scientists across the globe, broadcasting to and engaging the public for idea generation, harnessing a scalable workforce for quick data management, and fundraising for research endeavors, crowdsourcing creates novel opportunities for accelerating scientific progress. Copyright © 2015 Elsevier Ltd. All rights reserved.

Medical research and multidisciplinary applications with laser-accelerated beams: the ELIMED netwotk at ELI-Beamlines

Science.gov (United States)

Tramontana, A.; Anzalone, A.; Candiano, G.; Carpinelli, M.; Cirrone, G. A. P.; Cuttone, G.; Korn, G.; Licciardello, T.; Maggiore, M.; Manti, L.; Margarone, D.; Musumarra, A.; Perozziello, F.; Pisciotta, P.; Raffaele, L.; Romano, F.; Romano, F. P.; Stancampiano, C.; Schillaci, F.; Scuderi, V.; Torrisi, L.; Tudisco, S.

2014-04-01

Laser accelerated proton beams represent nowadays an attractive alternative to the conventional ones and they have been proposed in different research fields. In particular, the interest has been focused in the possibility of replacing conventional accelerating machines with laser-based accelerators in order to develop a new concept of hadrontherapy facilities, which could result more compact and less expensive. With this background the ELIMED (ELIMED: ELI-Beamlines MEDical applications) research project has been launched by LNS-INFN researchers (Laboratori Nazionali del Sud-Istituto Nazionale di Fisica Nucleare, Catania, IT) and ASCR-FZU researchers (Academy of Sciences of the Czech Republic-Fyzikální ústar, Prague, Cz), within the pan-European ELI-Beamlines facility framework. Its main purposes are the demonstration of future applications in hadrontherapy of optically accelerated protons and the realization of a laser-accelerated ion transport beamline for multidisciplinary applications. Several challenges, starting from laser-target interaction and beam transport development, up to dosimetric and radiobiological issues, need to be overcome in order to reach the final goals. The design and the realization of a preliminary beam handling and dosimetric system and of an advanced spectrometer for high energy (multi-MeV) laser-accelerated ion beams will be shortly presented in this work.

Accelerator research on MBE-4, an experimental multi-beam induction linac

International Nuclear Information System (INIS)

Meuth, H.; Fessenden, T.J.; Keefe, D.; Warwick, A.I.

1988-06-01

The multiple beam accelerator MBE-4 is a device for research toward a heavy ion driver for inertial confinement fusion, based on the induction linac concept. Its main goal is proof of the principle of current amplification by acceleration and controlled self-similar beam pulse compression. Into the 16-m long device four beams, each with an initial current of 10 mA are injected from a Marx-driven diode at 200 keV. The current amplification is up to nine-fold, with a final beam energy of about 800 keV in the middle of the bunch. Now that all the apparatus' accelerator sections have been completed, installed and aligned, and its unaccelerated transport properties have been studied, our experimental research has reached the crucial phase of implementing appropriate accelerator schedules that approximate self-similar current-pulse compression. These schedules are established through a close interplay of computations using a one-dimensional simulation code and a manual empirical tuning procedure. In a first approach, with a rather vigorous schedule that uses most of the accelerator modules to their voltage limits, we have determined the limits of our capability for controlled pulse compression, mainly due to waveform shaping of the driving pulse-forming networks. We shall report on these results. In the future, we will also aim for gentler schedules that would model more closely an inertial confinement fusion scenario. 8 refs., 11 figs., 1 tab

Prostate Cancer Stem-Like Cells | Center for Cancer Research

Science.gov (United States)

Prostate cancer is the third leading cause of cancer-related death among men, killing an estimated 27,000 men each year in the United States. Men with advanced prostate cancer often become resistant to conventional therapies. Many researchers speculate that the emergence of resistance is due to the presence of cancer stem cells, which are believed to be a small subpopulation

Basic research on cancer related to radiation associated medical researches

International Nuclear Information System (INIS)

Lee, Jong In; Hwang, Dae Yong; Bang, Ho Yoon

2000-12-01

Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed

Basic research on cancer related to radiation associated medical researches

Energy Technology Data Exchange (ETDEWEB)

Lee, Jong In; Hwang, Dae Yong; Bang, Ho Yoon [and others

2000-12-01

Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed.

Oncotyrol--Center for Personalized Cancer Medicine: Methods and Applications of Health Technology Assessment and Outcomes Research.

Science.gov (United States)

Siebert, Uwe; Jahn, Beate; Rochau, Ursula; Schnell-Inderst, Petra; Kisser, Agnes; Hunger, Theresa; Sroczynski, Gaby; Mühlberger, Nikolai; Willenbacher, Wolfgang; Schnaiter, Simon; Endel, Gottfried; Huber, Lukas; Gastl, Guenther

2015-01-01

The Oncotyrol - Center for Personalized Cancer Medicine is an international and interdisciplinary alliance combining research and commercial competencies to accelerate the development, evaluation and translation of personalized healthcare strategies in cancer. The philosophy of Oncotyrol is to collaborate with relevant stakeholders and advance knowledge "from bench to bedside to population and back". Oncotyrol is funded through the COMET Excellence Program by the Austrian government via the national Austrian Research Promotion Agency (FFG). This article focuses on the role of health technology assessment (HTA) and outcomes research in personalized cancer medicine in the context of Oncotyrol. Oncotyrol, which currently comprises approximately 20 individual projects, has four research areas: Area 1: Biomarker and Drug Target Identification; Area 2: Assay Development and Drug Screening; Area 3: Innovative Therapies; Area 4: Health Technology Assessment and Bioinformatics. Area 4 translates the results from Areas 1 to 3 to populations and society and reports them back to Area 3 to inform clinical studies and guidelines, and to Areas 1 and 2 to guide further research and development. In a series of international expert workshops, the Oncotyrol International Expert Task Force for Personalized Cancer Medicine developed the Methodological Framework for Early Health Technology Assessment and Decision Modeling in Cancer and practical guidelines in this field. Further projects included applications in the fields of sequential treatment of patients with chronic myeloid leukemia (CML), benefit-harm and cost-effectiveness evaluation of prostate cancer screening, effectiveness and cost-effectiveness of multiple cervical cancer screening strategies, and benefits and cost-effectiveness of genomic test-based treatment strategies in breast cancer. An interdisciplinary setting as generated in Oncotyrol provides unique opportunities such as systematically coordinating lab and bench

Cancer Trends: Influencing Care and Research Priorities

Science.gov (United States)

Many of the trends being seen in cancer are changing how we view cancer and how we address it, from prompting research to identify the underlying causes of cancers increasing in incidence to informing research on treatment and prevention.

Recent progress on laser acceleration research

International Nuclear Information System (INIS)

Nakajima, Kazuhisa; Dewa, Hideki; Hosokai, Tomonao; Kanazawa, Shuhei; Kando, Masaki; Kondoh, Shuji; Kotaki, Hideyuki

2000-01-01

Recently there has been a tremendous experimental progress in ultrahigh field particle acceleration driven by ultraintense laser pulses in plasmas. A design of the laser wakefield accelerators aiming at GeV energy gains is discussed by presenting our recent progress on the laser wakefield acceleration experiments, the developments of high quality electron beam injectors and the capillary plasma waveguide for optical guiding of ultrashort intense laser pulses. (author)

VEDs for charged particle accelerators: Indian scenario

International Nuclear Information System (INIS)

Bhandari, R.K.

2012-01-01

In the initial times after their invention, the charged particle accelerators have, primarily, been used for fundamental studies on nuclei and atoms. From the first modern accelerator, the cathode ray tube, used by J.J. Thomson for the discovery of electron, very recently the gigantic 27 km circumference Large Hadron Collider (LHC) is operational in the search of Higg's boson and related physics issues. Particle accelerators have emerged as powerful microscopes for investigating the finest details of cells, genes, molecules, atoms, protons, neutrons, muons, electrons, quarks and, possibly, still undiscovered even more fundamental constituents of the universe, such as dark matter and dark energy. Several noble prize winning discoveries have been made using accelerators. Accelerators are now being used in a wide area of industrial and medical applications. They are used for the production of radioisotopes for medical imaging, cancer therapy, food sterilization, treatment of waste water, sterilization of medical equipment, material modification, mass spectroscopy, cargo scanning, fabrication of semiconductors etc. Ongoing effort towards the development of accelerators with megawatt beam power is showing hope for a cleaner source of nuclear energy and treatment of nuclear waste. Several tens of thousands of accelerators are presently operational in the world for basic research and applications. Development of new accelerators has several times been driven by new technologies and materials and sometimes they have driven the technological developments towards cutting edge. Some examples are ultra-high vacuum in large volumes, superfluid helium in cryogenics, cryocoolers, superconducting magnets and RF cavities, high power vacuum electronic devices, global control systems, superfast computing and communication networks, giant data storage/processing systems etc. India has been pursuing a fairly robust programme of accelerator development at various institutions. It

Accelerator and Fusion Research Division annual report, fiscal year 1980, October 1979-September 1980

International Nuclear Information System (INIS)

1981-03-01

Research during October 1979 to September 1980 is summarized. Areas covered include: accelerator operations; positron-electron project; stochastic beam cooling; high-field superconducting magnets; accelerator theory; neutral beam sources; and heavy ion fusion

Cancer Genetics and Signaling | Center for Cancer Research

Science.gov (United States)

The Cancer, Genetics, and Signaling (CGS) Group at the National Cancer Institute at Frederick  offers a competitive postdoctoral training and mentoring program focusing on molecular and genetic aspects of cancer. The CGS Fellows Program is designed to attract and train exceptional postdoctoral fellows interested in pursuing independent research career tracks. CGS Fellows participate in a structured mentoring program designed for scientific and career development and transition to independent positions.

Automation of Technology for Cancer Research.

Science.gov (United States)

van der Ent, Wietske; Veneman, Wouter J; Groenewoud, Arwin; Chen, Lanpeng; Tulotta, Claudia; Hogendoorn, Pancras C W; Spaink, Herman P; Snaar-Jagalska, B Ewa

2016-01-01

Zebrafish embryos can be obtained for research purposes in large numbers at low cost and embryos develop externally in limited space, making them highly suitable for high-throughput cancer studies and drug screens. Non-invasive live imaging of various processes within the larvae is possible due to their transparency during development, and a multitude of available fluorescent transgenic reporter lines.To perform high-throughput studies, handling large amounts of embryos and larvae is required. With such high number of individuals, even minute tasks may become time-consuming and arduous. In this chapter, an overview is given of the developments in the automation of various steps of large scale zebrafish cancer research for discovering important cancer pathways and drugs for the treatment of human disease. The focus lies on various tools developed for cancer cell implantation, embryo handling and sorting, microfluidic systems for imaging and drug treatment, and image acquisition and analysis. Examples will be given of employment of these technologies within the fields of toxicology research and cancer research.

Bioprinting for cancer research.

Science.gov (United States)

Knowlton, Stephanie; Onal, Sevgi; Yu, Chu Hsiang; Zhao, Jean J; Tasoglu, Savas

2015-09-01

Bioprinting offers the ability to create highly complex 3D architectures with living cells. This cutting-edge technique has significantly gained popularity and applicability in several fields. Bioprinting methods have been developed to effectively and rapidly pattern living cells, biological macromolecules, and biomaterials. These technologies hold great potential for applications in cancer research. Bioprinted cancer models represent a significant improvement over previous 2D models by mimicking 3D complexity and facilitating physiologically relevant cell-cell and cell-matrix interactions. Here we review bioprinting methods based on inkjet, microextrusion, and laser technologies and compare 3D cancer models with 2D cancer models. We discuss bioprinted models that mimic the tumor microenvironment, providing a platform for deeper understanding of cancer pathology, anticancer drug screening, and cancer treatment development. Copyright © 2015 Elsevier Ltd. All rights reserved.

Patient-centered prioritization of bladder cancer research.

Science.gov (United States)

Smith, Angela B; Chisolm, Stephanie; Deal, Allison; Spangler, Alejandra; Quale, Diane Z; Bangs, Rick; Jones, J Michael; Gore, John L

2018-05-04

Patient-centered research requires the meaningful involvement of patients and caregivers throughout the research process. The objective of this study was to create a process for sustainable engagement for research prioritization within oncology. From December 2014 to 2016, a network of engaged patients for research prioritization was created in partnership with the Bladder Cancer Advocacy Network (BCAN): the BCAN Patient Survey Network (PSN). The PSN leveraged an online bladder cancer community with additional recruitment through print advertisements and social media campaigns. Prioritized research questions were developed through a modified Delphi process and were iterated through multidisciplinary working groups and a repeat survey. In year 1 of the PSN, 354 patients and caregivers responded to the research prioritization survey; the number of responses increased to 1034 in year 2. The majority of respondents had non-muscle-invasive bladder cancer (NMIBC), and the mean time since diagnosis was 5 years. Stakeholder-identified questions for noninvasive, invasive, and metastatic disease were prioritized by the PSN. Free-text questions were sorted with thematic mapping. Several questions submitted by respondents were among the prioritized research questions. A final prioritized list of research questions was disseminated to various funding agencies, and a highly ranked NMIBC research question was included as a priority area in the 2017 Patient-Centered Outcomes Research Institute announcement of pragmatic trial funding. Patient engagement is needed to identify high-priority research questions in oncology. The BCAN PSN provides a successful example of an engagement infrastructure for annual research prioritization in bladder cancer. The creation of an engagement network sets the groundwork for additional phases of engagement, including design, conduct, and dissemination. Cancer 2018. © 2018 American Cancer Society. © 2018 American Cancer Society.

Research and development activities around the EUROTRANS accelerator for ADS applications

International Nuclear Information System (INIS)

Biarrotte, J. L.; Mueller, A. C.

2007-01-01

An Accelerator Driven System (ADS) for transmutation of nuclear waste typically requires a 600 MeV - 1 GeV accelerator delivering a proton flux of a few mAs for demonstrators, and of a few tens of mAs for large industrial systems. Such a machine belongs to the category of the high power proton accelerators, with an additional requirement for exceptional 'reliability': because of the induced thermal stress to the subcritical core, the number of unwanted 'beam-trips' should not exceed a few per year, a specification that is several orders of magnitude above usual performance. This paper briefly describes the reference solution adopted for such a machine, based on a linear superconducting accelerator, and presents the status of the Research and Development performed in this context. This work is performed within the 6th Framework Program EC project 'EUROTRANS' (EC Contract No: FI6W 516520, 'EUROTRANS')

Annual report of joint research for using heavy ion accelerator for cancer therapy of the fiscal year 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-04-01

The heavy ion project consisted of 2 parts; clinical studies using HIMAC and joint basic researches using it. The clinical studies have been satisfactorily progressed and the number of patients treated by HIMAC reached 230 in total by the end of the fiscal year 1996. In Japan, HIMAC is the only apparatus for heavy ion acceleration. Thus, a lot of concerns from not only the medical and biological fields, but also other fundamental fields are paid to HIMAC. Further, the beam of HIMAC has been attracting international concerns, especially in the fields such as simulation of cosmic environment by heavy ion beam, dose determination using the beam, international comparison of its biological effects, etc. The operating times of HIMAC in 1996 was ca. 4800 hours in total and of those ca. 2700 hours were used for joint researches. This annual report include 12 reports of clinical research group, 4 of diagnosis one 64 of biology one and 42 of physical and engineering one. (M.N.)

Accelerated hypofractionated three-dimensional conformal radiation therapy in the treatment of non-small cell lung cancer

International Nuclear Information System (INIS)

Yu Jinming; Zheng Aiqing; Yu Yonghua; Wang Xuetao; Yuan Shuanghu; Han Dali; Li Kunhai

2005-01-01

Objective: To evaluate the effect and complication of non-small-cell lung cancer (NSCLC) treated with accelerated hypofractionated three dimensional conforms] radiation therapy (3DCRT). Methods: There were squamous carcinoma 21, adenocarcinoma 7, squamous-adenocarcinoma 4 and other cancer 3. There were 17 stage I and 18 stage II. Thirty-five patients of NSCLC were treated with a dose of 30-48 Gy in 6 or 8 Gy per fraction, 3 times a week. The outcome of these patients Was analyzed. Results: The overall 1-, 2- and 3- Year survival rate was 78.2%, 46.9% and 36.3%, respectively. The 1- and 2-year recurrence-free survival rate was 64.6 % and 39.7 %, respectively. The acute radiation pneumonitis and late lung fibrosis rates were high. Univariate analysis showed that Vm was a significant predictor of acute radiation pneumonitis. Conclusion: Compared with accelerated hypofractionated irradiation, the routine conventional fractionated radiation therapy may be preferred for more patients of NSCLC. (authors)

Precedent Research on Compact Laser-plasma based Gantry for Cancer Therapy

International Nuclear Information System (INIS)

Hee, Park Seong; Jeong, Young Uk; Lee, Ki Tae; Kim, Kyung Nam; Cha, Young Ho

2012-03-01

This is the precedent R and D to develop the technology of next generation compact particle cancer treatment system based on laser-plasma interaction and to deduce a big project. The subject of this project are the survey of application technology of laser-plasma based particle beam and the design of compact laser-plasma based gantry. The survey of characteristic of particle beam for cancer therapy and present status can be adapted to develop new system. The comparison between particle beams from the existing system and new one based on laser-plasma acceleration will be important to new design and design optimization. The project includes design of multi-dimensional laser transfer beamline, minimization of laser-plasma acceleration chamber, design of effective energy separation/selection system, and radiation safety and local shielding

Techniques in cancer research: a laboratory manual

International Nuclear Information System (INIS)

Deo, M.G.; Seshadri, R.; Mulherkar, R.; Mukhopadhyaya, R.

1995-01-01

Cancer Research Institute (CRI) works on all facets of cancer using the latest biomedical tools. For this purpose, it has established modern laboratories in different branches of cancer biology such as cell and molecular biology, biochemistry, immunology, chemical and viral oncogenesis, genetics of cancer including genetic engineering, tissue culture, cancer chemotherapy, neurooncology and comparative oncology. This manual describes the protocols used in these laboratories. There is also a chapter on handling and care of laboratory animals, an essential component of any modern cancer biology laboratory. It is hoped that the manual will be useful to biomedical laboratories, specially those interested in cancer research. refs., tabs., figs

Neutron physics and nuclear data measurements with accelerators and research reactors

International Nuclear Information System (INIS)

1988-08-01

The report contains a collection of lectures devoted to the latest theoretical and experimental developments in the field of fast neutron physics and nuclear data measurements. The possibilities offered by particle accelerators and research reactors for research and technological applications in these fields are pointed out. Refs, figs and tabs

Neutron physics and nuclear data measurements with accelerators and research reactors

International Nuclear Information System (INIS)

1985-08-01

The report contains a collection of lectures devoted to the latest theoretical and experimental developments in the field of fast neutron measurements and in the studies of neutron interactions with nuclei. The possibilities offered by particle accelerators and research reactors for research and technological applications in these fields are pointed out

Graduate Student Program in Materials and Engineering Research and Development for Future Accelerators

Energy Technology Data Exchange (ETDEWEB)

Spentzouris, Linda [Illinois Inst. of Technology, Chicago, IL (United States)

2016-07-07

The objective of the proposal was to develop graduate student training in materials and engineering research relevant to the development of particle accelerators. Many components used in today's accelerators or storage rings are at the limit of performance. The path forward in many cases requires the development of new materials or fabrication techniques, or a novel engineering approach. Often, accelerator-based laboratories find it difficult to get top-level engineers or materials experts with the motivation to work on these problems. The three years of funding provided by this grant was used to support development of accelerator components through a multidisciplinary approach that cut across the disciplinary boundaries of accelerator physics, materials science, and surface chemistry. The following results were achieved: (1) significant scientific results on fabrication of novel photocathodes, (2) application of surface science and superconducting materials expertise to accelerator problems through faculty involvement, (3) development of instrumentation for fabrication and characterization of materials for accelerator components, (4) student involvement with problems at the interface of material science and accelerator physics.

Researching the experience of kidney cancer patients.

Science.gov (United States)

Taylor, K

2002-09-01

The author's personal experience as a kidney cancer patient, researcher and founder of a kidney cancer support group forms the basis for consideration of the challenges involved in researching patients' experiences. The researcher needs to understand the variability of those experiences in both clinical and psychological-emotional terms, and in relation to the personal, familial and social contexts of the patient. It is also essential to define the purpose of the research and to show how an understanding of personal experiences of cancer can be used to enhance the quality of care for cancer patients. The research encounter with a patient is also in some respects a therapeutic encounter requiring a considerable degree of sensitivity on the part of the researcher. The person-centred approach of Carl Rogers is of value in supporting such an encounter.

Current concepts in cancer research

OpenAIRE

Ivan Kok Seng Yap; Ammu Kutty Radhakrishnan; Chee Onn Leong

2013-01-01

Cancer research is an extremely broadtopic covering many scientific disciplines includingbiology (e.g. biochemistry and signal transduction),chemistry (e.g. drug discover and development),physics (e.g. diagnostic devices) and even computerscience (e.g. bioinformatics). Some would argue thatcancer research will continue in much the same wayas it is by adding further layers of complexity to thescientific knowledge that is already complex and almostbeyond measure. But we anticipate that cancer r...

Potential clinical impact of laser-accelerated beams in cancer ion therapy

Energy Technology Data Exchange (ETDEWEB)

Obcemea, Ceferino

2016-09-01

In this article, I present three advantages of plasma-accelerated ion beams for cancer therapy. I discuss how: 1. low-emittance and well-collimated beams are advantageous in proximal normal tissue-sparing; 2. highly-peaked quasi-monoenergetic beams are ideal for fast energy selection and switching in Pencil Beam Scanning (PBS) as a treatment delivery; 3. high fluence and ultra-short pulse delivery produce collective excitations in the medium and enhance the stopping power. This in turn produces denser ionization track signatures (spurs, blobs, etc.) in target tumors, higher linear energy transfer, higher Bragg peak, and higher radiobiological effectiveness at the micro-level.

Research opportunities with compact accelerator-driven neutron sources

Energy Technology Data Exchange (ETDEWEB)

Anderson, I.S. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Andreani, C., E-mail: carla.andreani@uniroma2.it [Università degli Studi di Roma “Tor Vergata”, Physics Department and NAST Centre, Via della Ricerca Scientifica 1, 00133 Roma (Italy); CNR-IPCF Sezione di Messina, Messina (Italy); Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Roma (Italy); Carpenter, J.M. [Argonne National Laboratory, Argonne, IL (United States); Festa, G., E-mail: giulia.festa@uniroma2.it [Università degli Studi di Roma “Tor Vergata”, Physics Department and NAST Centre, Via della Ricerca Scientifica 1, 00133 Roma (Italy); Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Roma (Italy); Gorini, G. [Università degli Studi di Milano—Bicocca, Milano (Italy); Loong, C.-K. [Università degli Studi di Roma “Tor Vergata”, Centro NAST, Via della Ricerca Scientifica 1, 00133 Roma (Italy); Senesi, R. [Università degli Studi di Roma “Tor Vergata”, Physics Department and NAST Centre, Via della Ricerca Scientifica 1, 00133 Roma (Italy); CNR-IPCF Sezione di Messina, Messina (Italy); Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Roma (Italy)

2016-10-13

Since the discovery of the neutron in 1932 neutron beams have been used in a very broad range of applications, As an aging fleet of nuclear reactor sources is retired the use of compact accelerator-driven neutron sources (CANS) is becoming more prevalent. CANS are playing a significant and expanding role in research and development in science and engineering, as well as in education and training. In the realm of multidisciplinary applications, CANS offer opportunities over a wide range of technical utilization, from interrogation of civil structures to medical therapy to cultural heritage study. This paper aims to provide the first comprehensive overview of the history, current status of operation, and ongoing development of CANS worldwide. The basic physics and engineering regarding neutron production by accelerators, target–moderator systems, and beam line instrumentation are introduced, followed by an extensive discussion of various evolving applications currently exploited at CANS.

Research opportunities with compact accelerator-driven neutron sources

International Nuclear Information System (INIS)

Anderson, I.S.; Andreani, C.; Carpenter, J.M.; Festa, G.; Gorini, G.; Loong, C.-K.; Senesi, R.

2016-01-01

Since the discovery of the neutron in 1932 neutron beams have been used in a very broad range of applications, As an aging fleet of nuclear reactor sources is retired the use of compact accelerator-driven neutron sources (CANS) is becoming more prevalent. CANS are playing a significant and expanding role in research and development in science and engineering, as well as in education and training. In the realm of multidisciplinary applications, CANS offer opportunities over a wide range of technical utilization, from interrogation of civil structures to medical therapy to cultural heritage study. This paper aims to provide the first comprehensive overview of the history, current status of operation, and ongoing development of CANS worldwide. The basic physics and engineering regarding neutron production by accelerators, target–moderator systems, and beam line instrumentation are introduced, followed by an extensive discussion of various evolving applications currently exploited at CANS.

Research opportunities with compact accelerator-driven neutron sources

Science.gov (United States)

Anderson, I. S.; Andreani, C.; Carpenter, J. M.; Festa, G.; Gorini, G.; Loong, C.-K.; Senesi, R.

2016-10-01

Since the discovery of the neutron in 1932 neutron beams have been used in a very broad range of applications, As an aging fleet of nuclear reactor sources is retired the use of compact accelerator-driven neutron sources (CANS) is becoming more prevalent. CANS are playing a significant and expanding role in research and development in science and engineering, as well as in education and training. In the realm of multidisciplinary applications, CANS offer opportunities over a wide range of technical utilization, from interrogation of civil structures to medical therapy to cultural heritage study. This paper aims to provide the first comprehensive overview of the history, current status of operation, and ongoing development of CANS worldwide. The basic physics and engineering regarding neutron production by accelerators, target-moderator systems, and beam line instrumentation are introduced, followed by an extensive discussion of various evolving applications currently exploited at CANS.

Research in Danish cancer rehabilitation

DEFF Research Database (Denmark)

Høybye, Mette Terp; Dalton, Susanne Oksbjerg; Christensen, Jane

2008-01-01

rate at baseline was 86% (n = 1876). Most participants were younger women with breast cancer. They were generally well educated and working. The cancer survivors reported having comprehensive social networks and being physically active. Several cancer-related symptoms were reported by women...... site, sex, age, family, working status and social position. These challenges might be addressed optimally in multi-dimensional rehabilitation programmes....... of the cancer survivors with respect to cancer site, sociodemographic variables, social network, lifestyle, self-rated health and the prevalence of cancer-related late effects. The study is part of the FOCARE research project, in which the long-term effects of the rehabilitation programme are evaluated...

Accelerating knowledge to action: the pan-Canadian cancer control strategy.

Science.gov (United States)

Fairclough, L; Hill, J; Bryant, H; Kitchen-Clarke, L

2012-04-01

In 2006, the federal government committed funding of $250 million over 5 years for the Canadian Partnership Against Cancer Corporation to begin implementation of the Canadian Strategy for Cancer Control (CSCC). The Partnership was established as a not-for-profit corporation designed to work actively with a broad range of stakeholders and organizations that had been engaged in the development of the CSCC and with the public more broadly. A policy experiment unto itself, the Partnership was the first disease-based organization funded at the federal level outside of government. It was charged with a mandate to enable transfer of knowledge and to catalyze coordinated and accelerated action across the country to reduce the burden of cancer. Implementation has involved establishing shared goals, objectives, and plans with participating partners. Knowledge management-incorporating pan-Canadian approaches to the identification of content, processes, technology, and culture change-was used to enable that work across the federated health care delivery system. Evaluation of the organization through independent review, the ability to achieve initiative-level targets by 2012, and progress measured using indicators of system performance was used to examine the effectiveness of the strategy and approach overall. Evaluation findings support the conclusions that Canada has made progress in achieving immediate outcomes (achievable in 25 years) impact on cancer. The mechanism of funding the Partnership to develop collaboration among stakeholders in cancer control to achieve coordinated action has been possible and has been enabled through the Partnership's knowledge-to-action mandate. Opportunities are available to further engage and clarify the roles of stakeholders in action, to clearly define outcomes, and to further quantify the economic benefits that have resulted from a coordinated approach. With the ongoing funding commitment to support coordinated action within a federated

Pre-Cancer Atlas (PCA) and Other Human Tumor Atlas Network (HTAN) Funding Opportunity Announcements (FOAs) Released | Division of Cancer Prevention

Science.gov (United States)

There are 3 new funding opportunity announcements about the Pre-Cancer Atlas associated with the Beau Biden Cancer MoonshotSM Initiative that are intended to accelerate cancer research. The purpose of the FOAs is to promote research that results in a comprehensive view of the dynamic, multidimensional tumor ecosystem and is a direct response to the Moonshot Blue Ribbon Panel recommendation to generate human tumor atlases. |

Researching experiences of cancer: the importance of methodology.

Science.gov (United States)

Entwistle, V; Tritter, J Q; Calnan, M

2002-09-01

This paper draws on contributions to and discussions at a recent MRC HSRC-sponsored workshop 'Researching users' experiences of health care: the case of cancer'. We focus on the methodological and ethical challenges that currently face researchers who use self-report methods to investigate experiences of cancer and cancer care. These challenges relate to: the theoretical and conceptual underpinnings of research; participation rates and participant profiles; data collection methods (the retrospective nature of accounts, description and measurement, and data collection as intervention); social desirability considerations; relationship considerations; the experiences of contributing to research; and the synthesis and presentation of findings. We suggest that methodological research to tackle these challenges should be integrated into substantive research projects to promote the development of a strong knowledge base about experiences of cancer and cancer care.

Cancer as a Social Dysfunction - Why Cancer Research Needs New Thinking.

Science.gov (United States)

Pienta, Kenneth J; Axelrod, Robert

2018-05-21

The incidence and mortality for many cancers continues to rise. As such, critical action is needed on many fronts to reshape how a society thinks, discusses, and fights cancer especially as the population grows and ages. Cancer can be described as a broken social contract which requires different conceptual frameworks such as game theory. To this end, it is our hope that this perspective will catalyze a discussion to rethink the way we approach, communicate, and fund cancer research - thinking of cancer as a broken social contract is only one example. Importantly, this endeavor will require infusion of ideas from other fields such as physics, computational medicine, complexity science, agent-based modeling, sociology, and ecology all of which have the capacity to drive new insights into cancer biology and clinical medicine. Copyright ©2018, American Association for Cancer Research.

The miniature accelerator

CERN Multimedia

Antonella Del Rosso

2015-01-01

The image that most people have of CERN is of its enormous accelerators and their capacity to accelerate particles to extremely high energies. But thanks to some cutting-edge studies on beam dynamics and radiofrequency technology, along with innovative construction techniques, teams at CERN have now created the first module of a brand-new accelerator, which will be just 2 metres long. The potential uses of this miniature accelerator will include deployment in hospitals for the production of medical isotopes and the treatment of cancer. It’s a real David-and-Goliath story.   Serge Mathot, in charge of the construction of the "mini-RFQ", pictured with the first of the four modules that will make up the miniature accelerator. The miniature accelerator consists of a radiofrequency quadrupole (RFQ), a component found at the start of all proton accelerator chains around the world, from the smallest to the largest. The LHC is designed to produce very high-intensity beams ...

Flow Cytometry Technician | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Basic Science Program (BSP) pursues independent, multidisciplinary research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR). KEY ROLES/RESPONSIBILITIES The Flow Cytometry Core (Flow Core) of the Cancer and Inflammation Program (CIP) is a service core which supports the research efforts of the CCR by providing expertise in the field of flow cytometry (using analyzers and sorters) with the goal of gaining a more thorough understanding of the biology of cancer and cancer cells. The Flow Core provides service to 12-15 CIP laboratories and more than 22 non-CIP laboratories. Flow core staff provide technical advice on the experimental design of applications, which include immunological phenotyping, cell function assays, and cell cycle analysis. Work is performed per customer requirements, and no independent research is involved. The Flow Cytometry Technician will be responsible for: Monitor performance of and maintain high dimensional flow cytometer analyzers and cell sorters Operate high dimensional flow cytometer analyzers and cell sorters Monitoring lab supply levels and order lab supplies, perform various record keeping responsibilities Assist in the training of scientific end users on the use of flow cytometry in their research, as well as how to operate and troubleshoot the bench-top analyzer instruments Experience with sterile technique and tissue culture

Accelerator development for medical applications

International Nuclear Information System (INIS)

Tanabe, Eiji

2007-01-01

Electron linear accelerators have been widely used in medical applications, especially in radiation therapy for cancer treatment. There are more than 7,000 medical electron linear accelerators in the world, treating over 250,000 patients per day. This paper reviews the current status of accelerator applications and technologies in radiation therapy, and presents the anticipated requirements for advanced radiation therapy technology in the foreseeable future. (author)

Research on cw electron accelerators using room-temperature rf structures: Annual report

International Nuclear Information System (INIS)

1986-01-01

This joint NBS-Los Alamos project of ''Research on CW Electron Accelerators Using Room-Temperature RF Structures'' began seven years ago with the goal of developing a technology base for cw electron accelerators. In this report we describe our progress during FY 1986 and present our plans for completion of the project. First, however, it is appropriate to review the past contributions of the project, describe its status, and indicate its future benefits

Translational Partnership Development Lead | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Frederick National Laboratory for Cancer Research (FNLCR) is a Federally Funded Research and Development Center operated by Leidos Biomedical Research, Inc on behalf of the National Cancer Institute (NCI). The staff of FNLCR support the NCI’s mission in the fight against cancer and HIV/AIDS. Currently we are seeking a Translational Partnership

Gaps in nutritional research among older adults with cancer

Science.gov (United States)

Presley, Carolyn J.; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G.; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D.; Wildes, Tanya M.; Mustian, Karen; Demark-Wahnefried, Wendy

2016-01-01

Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research. PMID:27197919

Heavy Ion Fusion Accelerator Research (HIFAR)

International Nuclear Information System (INIS)

1991-04-01

This report discusses the following topics: emittance variations in current-amplifying ion induction lina; transverse emittance studies of an induction accelerator of heavy ions; drift compression experiments on MBE-4 and related emittance; low emittance uniform- density C s + sources for heavy ion fusion accelerator studies; survey of alignment of MBE-4; time-of-flight dependence on the MBE-4 quadrupole voltage; high order calculation of the multiple content of three dimensional electrostatic geometries; an induction linac injector for scaled experiments; induction accelerator test module for HIF; longitudinal instability in HIF beams; and analysis of resonant longitudinal instability in a heavy ion induction linac

Communications Specialist | Center for Cancer Research

Science.gov (United States)

Be part of our mission to support research against cancer. We have an exciting opportunity for a talented communicator to join our team and be part of the effort to find cures for cancer. We are looking for a creative, team-oriented communications professional, with strong writing skills to publicize our research advances, employment and training opportunities and clinical

CCR Interns | Center for Cancer Research

Science.gov (United States)

The Cancer Research Interns (CRI) Summer Program was inaugurated in 2004 to provide an open door for students looking for an initial training opportunity. The goal is to enhance diversity within the CCR (Center for Cancer Research) training program and we have placed 338 students from 2004 to 2017, in labs and branches across the division.  The CCR and the Center for Cancer Training’s Office of Training and Education provide stipend support, some Service & Supply funds, and travel support for those students who meet the financial eligibility criteria (

Creating a data exchange strategy for radiotherapy research : Towards federated databases and anonymised public datasets

NARCIS (Netherlands)

Skripcak, Tomas; Belka, Claus; Bosch, Walter; Brink, Carsten; Brunner, Thomas; Budach, Volker; Buettner, Daniel; Debus, Juergen; Dekker, Andre; Grau, Cai; Gulliford, Sarah; Hurkmans, Coen; Just, Uwe; Krause, Mechthild; Lambin, Philippe; Langendijk, Johannes A.; Lewensohn, Rolf; Luehr, Armin; Maingon, Philippe; Masucci, Michele; Niyazi, Maximilian; Poortmans, Philip; Simon, Monique; Schmidberger, Heinz; Spezi, Emiliano; Stuschke, Martin; Valentini, Vincenzo; Verheij, Marcel; Whitfield, Gillian; Zackrisson, Bjoern; Zips, Daniel; Baumann, Michael

2014-01-01

Disconnected cancer research data management and lack of information exchange about planned and ongoing research are complicating the utilisation of internationally collected medical information for improving cancer patient care. Rapidly collecting/pooling data can accelerate 'translational research

Creating a data exchange strategy for radiotherapy research: Towards federated databases and anonymised public datasets

NARCIS (Netherlands)

Skripcak, T.; Belka, C.; Bosch, W.; Brink, C. Van den; Brunner, T.; Budach, V.; Buttner, D.; Debus, J.; Dekker, A.; Grau, C.; Gulliford, S.; Hurkmans, C.; Just, U.; Krause, M.; Lambin, P.; Langendijk, J.A.; Lewensohn, R.; Luhr, A.; Maingon, P.; Masucci, M.; Niyazi, M.; Poortmans, P.M.P.; Simon, M.; Schmidberger, H.; Spezi, E.; Stuschke, M.; Valentini, V.; Verheij, M.; Whitfield, G.; Zackrisson, B.; Zips, D.; Baumann, M.

2014-01-01

Disconnected cancer research data management and lack of information exchange about planned and ongoing research are complicating the utilisation of internationally collected medical information for improving cancer patient care. Rapidly collecting/pooling data can accelerate translational research

Current cancer research. Reports from the German Cancer Research Center 1998; Krebsforschung heute. Berichte aus dem Deutschen Krebsforschungszentrum 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-31

Topics from the Contents: The Fight against Cancer in Germany - A Critical Review. Conditions and Structures in Research. Familial Breast Cancer - A Critical Assessment. Research without Animal Experiments. Cancer Prevention. New Approaches for Tumor Therapy. Genes, Chromosomes and Cancer. Therapy of Brain Tumors with Laser Neurosurgery. The Genome Project. (orig.) [Deutsch] Krebsbekaempfung in Deutschland - kritische Ueberlegungen. Forschungsbedingungen und -strukturen. Forschung ohne Tierversuche. Familiaerer Brustkrebs - eine Risikoabschaetzung. Krebspraevention. Neue Therapieansaetze. Laser-Neurochirurgie bei Hirntumoren. Das Genomprojekt. Gene, Chromosomen und Krebs. (orig.)

Towards meeting the research needs of Australian cancer consumers

Directory of Open Access Journals (Sweden)

Saunders Carla

2012-12-01

Full Text Available Abstract Background There is a growing amount of literature to support the view that active involvement in research by consumers, especially informed and networked consumers, benefits the quality and direction of research itself, the research process and, most importantly, people affected by cancer. Our exploratory project focuses on identifying their priorities and developing a process to assess the research needs of Australian cancer consumers which may be useful beyond the cancer scenario. Methods This project was consumer initiated, developed and implemented, with the assistance of a leading Australian cancer consumer advocacy group, Cancer Voices NSW (CVN. Such direct involvement is unusual and ensures that the priorities identified, and the process itself, are not influenced by other interests, regardless how well-intentioned they may be. The processes established, and data collection via a workshop, followed by a questionnaire to confirm and prioritise findings, and comparison with a similar UK exercise, are detailed in this paper. Results Needs across five topic areas reflecting cancer control domains (prevention and risk; screening and diagnosis; treatment; survivorship; and end of life were identified. Cancer consumers high priority research needs were found to be: earlier diagnosis of metastatic cancers; the extent of use of best practice palliative care guidelines; identifying barriers to cancer risk behaviour change; and environmental, nutrition and lifestyle risk factors for people with cancer. A process for identifying consumers’ research priorities was developed and applied; this may be useful for further investigation in this under-studied area. Conclusion The findings provide a model for developing a consumer derived research agenda in Australia which can be used to inform the strategic direction of cancer research. Consumers have been seeking a workable method to achieve this and have worked in collaboration with a major

Antimatter cancer treatment

CERN Multimedia

Van Noorden, Richard

2006-01-01

"The idea that antimatter beams could treat cancer might seem ridiculous. But researchers working at Cerns particle accelerator laboratory in Geneva don't think so. They have just reported a successful first experiment into the biological effects of antiprotons radiation on living cells."

Annual Report of the Tandem Accelerator Center, Nuclear and Solid State Research Project, University of Tsukuba

International Nuclear Information System (INIS)

1978-01-01

In 1977, 12 UD Pelletron tandem accelerator has been operated by the University's researchers and engineers. Except for the tank opening for regular inspection we met twice the troubles which forced to change the accelerating tube. The experiences teach us that it needs about 20 days to finish the conditioning after changing the accelerating tube. A sputter ion source of new version is now being installed on the top floor. Two devices for the detection of X-rays were tested. An apparatus for bombardment of samples in air for biological and medical sciences has been successfully used. The subjects of researches on nuclear physics cover the light-ion reactions, heavy-ion reactions and nuclear spectroscopy. A special emphasis has been put on the measurements on vector- and tensor-analyzing powers in the light-ion reactions, because of a higher efficiency of the polarized ion source. Elaborate works on the heavy-ion reactions including the angular correlation patterns and excitation functions have been made in parallel. Papers of these works are now being prepared, a few having been published already. Moreover, in the University of Tsukuba, a new research system, called Special Research Project on Nuclear and Solid State Sciences Using Accelerated Beams (Nuclear and Solid State Research Project) started in 1978 and will continue for five years. In this research project, researchers from various Institutes in the University of Tsukuba, as well as visiting researchers from other institutions in Japan and from abroad, participate. Using a variety of accelerated beams, i.e. of heavy, light and polarized beams, this research project aims mainly at the high excitation, short life, transient and inhomogeneous states both in nuclear and extra-nuclear world. It covers both fundamental research in nuclear, atomic and solid state sciences as well as their application in various fields. (J.P.N.)

Scientist, Single Cell Analysis Facility | Center for Cancer Research

Science.gov (United States)

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives.  The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR).  The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and nextGen sequencing. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR).  CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. KEY ROLES AND RESPONSIBILITIES We are seeking a highly motivated Scientist II to join the newly established Single Cell Analysis Facility (SCAF) of the Center for Cancer Research (CCR) at NCI. The SCAF will house state of the art single cell sequencing technologies including 10xGenomics Chromium, BD Genomics Rhapsody, DEPPArray, and other emerging single cell technologies. The Scientist: Will interact with close to 200 laboratories within the CCR to design and carry out single cell experiments for cancer research Will work on single cell isolation/preparation from various tissues and cells and related NexGen sequencing library preparation Is expected to author publications in peer reviewed scientific journals

MYRRHA: a multipurpose accelerator driven system for research and development

International Nuclear Information System (INIS)

Benoit, Ph.; Ait Abderrahim, H.; Kupschus, P.; Malambu, E.; Tichelen, K. van; Arien, B.; Vermeersch, F.; Jongen, Y.; Vandeplassche, D.; Ternier, S.

2001-01-01

SCK-CEN, the Belgian Nuclear Research Centre, and IBA s.a., Ion Beam Application, a world leader in accelerator technology, want to fulfil a prominent role in the Accelerator Driven Systems field and are designing an ADS prototype, the MYRRHA Project, and conducting an associated R and D programme. The partners are foreseeing MYRRHA as a first step towards the European ADS-Demo facility. The project focuses primarily on ADS related research, i.e. structural materials and nuclear fuel research, liquid metals and associated aspects, sub-critical reactor physics and subsequently on applications such as waste transmutation, radioisotope production and safety research on sub-critical systems. In this respect, the MYRRHA system should become a new major research infrastructure for the European partners presently involved in the ADS Demo development, supporting and enabling the international R and D programs. Ion Beam Applications, the Belgium world leader in particle accelerators, had joined the MYRRHA Project to perform the accelerator development. Currently the study and preliminary conceptual design of the MYRRHA system is going on and an intensive R and D programme is conducted to assess the most risky points of the present design. This study will define the final choice of the characteristics of the facility depending on the selected fields of application to be achieved. The MYRRHA concept, as it is today, is based on the coupling of an upgraded commercial proton accelerator with a spallation target surrounded by a subcritical neutron-multiplying medium. Its design is determined by the versatility m applications that should be made possible. Further technical and/or strategic developments of the project might change the concept. A cyclotron, based on positive ion acceleration technology brings the protons up to an energy level of 350 MeV. The nominal current is 5 mA of protons. The spallation target system consists in a circuit with, at the upper part, a free

Cancer Research in the Arab World

Science.gov (United States)

Hamadeh, Randah R.; Borgan, Saif M.; Sibai, Abla M.

2017-01-01

This review aimed to examine trends in cancer research in the Arab world and identify existing research gaps. A search of the MEDLINE® database (National Library of Medicine, Bethesda, Maryland, USA) was undertaken for all cancer-related publications published between January 2000 and December 2013 from seven countries, including Bahrain, Kuwait, Iraq, Lebanon, Morocco, Palestine and Sudan. A total of 1,773 articles were identified, with a significant increase in yearly publications over time (P social and structural determinants of health (27.1%), followed by behavioural risk factors (14.1%), particularly tobacco use. Overall, more cancer research is needed in the Arab world, particularly analytical studies with high-quality evidence and those focusing on older age groups and associations with physical activity and diet. PMID:28690885

Double-negative metamaterial research for accelerator applications

International Nuclear Information System (INIS)

Antipov, S.; Spentzouris, L.; Gai, W.; Liu, W.; Power, J.G.

2007-01-01

Material properties are central to the design of particle accelerators. One area of advanced accelerator research is to investigate novel materials and structures and their potential use in extending capabilities of accelerator components. Within the past decade a new type of artificially constructed material having the unique property of simultaneously negative permittivity and permeability has been realized, and is under intense investigation, primarily by the optical physics and microwave engineering communities [C.M. Soukoulis, Science 315 (2007) 47; D.R. Smith, J.B. Pendry, M.C.K. Wiltshire, Science 305 (2004) 788; J.B. Pendry, A.J. Holden, W.J. Stewart, I. Youngs, Phys. Rev. Lett. 76 (1996) 4773]. Although they are typically constructed of arrays of discrete cells, as long as the condition that the wavelength of applied radiation is significantly greater than the cell dimensions is met, the material mimics a continuous medium and can be described with the bulk properties of permittivity, ε, and permeability, μ. When the permittivity and permeability are simultaneously negative in some frequency range, the metamaterial is called double negative (DNM) or left-handed (LHM) and has unusual properties, such as a negative index of refraction. An investigation of these materials in the context of accelerators is being carried out by IIT and the Argonne Wakefield Accelerator Facility [S. Antipov, W. Liu, W. Gai, J. Power, L. Spentzouris, AIP Conf. Proc. 877 (2006); S. Antipov, W. Liu, J. Power, L. Spentzouris, Design, Fabrication, and Testing of Left-Handed Metamaterial, Wakefield Notes at Argonne Wakefield Accelerator, ]. Waveguides loaded with metamaterials are of interest because the DNM can change the dispersion relation of the waveguide significantly. For example, slow backward waves can be produced in a DNM-loaded waveguide without having corrugations. This article begins with a brief introduction of known design principles for realizing a DNM [J.B. Pendry, A

Electron Microscopy-Data Analysis Specialist | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives.  The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for

Next-generation particle accelerators for frontline research and wide-ranging applications in India - how to realize them?

International Nuclear Information System (INIS)

Bhandari, R.K.; Roy, Amit

2015-01-01

Several modern accelerator facilities have been set up in India for basic and applied research during the past 5 decades. Indian scientists have been able to carry out excellent accelerator-based research at these as well as international facilities. Applications of accelerators in healthcare and industry have also grown in recent years. There is a strong realization now, at all levels, that a quantum jump needs to be given to the field of accelerator science and technology in India to fulfil the aspirations of the research community to be at par internationally in our areas of strength. Applications in industry and healthcare also have to grow substantially to benefit the common man. In this article an analysis of the methodology and logic behind the evolution of our accelerator programme has been presented. More importantly, recommendations have been given for gainfully implementing a rather ambitious programme that is proposed to be taken up in the next few decades. (author)

The John Milner Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

Science.gov (United States)

The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health, and the U.S. Department of Agriculture’s Beltsville Human Nutrition Research Center are offering a one-week educational opportunity in Nutrition and Cancer Prevention Research for individuals with a sustained commitment to nutrition and health promotion. |

CCR Magazines | Center for Cancer Research

Science.gov (United States)

The Center for Cancer Research (CCR) has two magazines, MILESTONES and LANDMARKS, that highlight our annual advances and top contributions to the understanding, detection, treatment and prevention of cancer over the years.

Dedicated researcher brings cancer care to rural communities

Directory of Open Access Journals (Sweden)

Sharan Bhuller

2016-10-01

Full Text Available As an ardent cancer researcher, Dr. Smita Asthana has a vision to create wider awareness on cancer and its prevention, and aims to work on translational research to benefit the general public through the implementation of evidence-based research. “I have been associated with the National Institute of Cancer Prevention and Research (NICPR and Institute of Cytology and Preventive Oncology (ICPO since November 2004 and have progressed over a period of time from being a staff scientist to the current role of a senior scientist,” says Dr. Asthana, who is presently with NICPR’s Biostatistics and Epidemiology division.“I have been working in various positions that deal with the design, execution, and evaluation of medical projects. Recently, we have concluded two major cervical cancer screening projects and conducted a screening of 10,000 women in rural areas,” she tells AMOR. One project, funded by the Indian Council of Medical Research, was carried out 100 km west of New Delhi in the rural town of Dadri “as part of an operational research to see the implementation of VIA (visual inspection with acetic acid and VILI (visual inspection with Lugol's iodine screenings with the help of existing healthcare infrastructure,” she explains.As a leading researcher in cervical cancer screening, she completed an Indo-US collaborative project on the clinical performance of a human papillomavirus (HPV test, used as a strategy for screening cervical cancer in rural communities, with funding from the Bill and Melinda Gates Foundation via the international non-profit global health organization PATH. “The primary objective of the project was to observe the performance of careHPV, a new diagnostic kit, in a rural setup,” she says.CareHPV is a highly sensitive DNA test, which detects 14 different types of the human papillomavirus that cause cervical cancer, providing results more rapidly than other DNA tests and is designed especially for use in clinics

ACCELERATED REGIMENS OF ADJUVANT RADIOTHERAPY IN THE TREATMENT OF BREAST CANCER

Directory of Open Access Journals (Sweden)

G. V. Afonin

2017-01-01

Full Text Available Treatment of breast cancer (BC is a complex multidisciplinary problem. Often, radiation therapy is an obligatory component of treatment of breast cancer patients. Numerous large randomized trials have proved the efficacy of adjuvant radiotherapy in both the standard fractionation regimen in a single focal dose of 2 Gy to a total focal dose of 50 Gy for 25 fractions and in modes of hypofractionation using radiation exposure at a larger daily dose with a reduction in the total treatment time. The presented review summarizes the data of the largest studies on the modes of hypofractionation of postoperative radiotherapy for breast cancer. Most of the studies comparing the standard mode of fractionation of postoperative radiotherapy with the modes of hypofractionation showed comparable results for the main oncological parameters with similar tolerability, frequency of complications and good cosmetic results. It also shows the economic feasibility of applying accelerated regimes in everyday practice. Despite the fact that radiotherapy in the mode of hypofractionation has already become the standard of treatment and is recommended for use by the largest European and American cancer associations, indications for its conduct, the criteria for selection in the studies and the range of recommended single focal doses differ. The obtained results do not give an opportunity to confidently judge the advantage of one or another regime. It is necessary to determine the factors of a favorable and unfavorable prognosis, to clarify the indications for the use of various radiotherapy techniques. Therefore, questions about the optimal mode of hypo-fractionation of adjuvant radiotherapy, the timing of its initiation and the criteria for selecting patients for this type of therapy as part of the comprehensive treatment of breast cancer have not yet been fully resolved. Also open is the choice of optimal single and total doses of radiation, its combination with drug

Circulating Microvesicles from Pancreatic Cancer Accelerate the Migration and Proliferation of PANC-1 Cells.

Science.gov (United States)

An, Mingrui; Zhu, Jianhui; Wu, Jing; Cuneo, Kyle C; Lubman, David M

2018-04-06

Circulating microvesicles are able to mediate long-distance cell-cell communications. It is essential to understand how microvesicles from pancreatic cancer act on other cells in the body. In this work, serum-derived microvesicles were isolated from 10 patients with locally advanced pancreatic cancer and healthy controls. Using Cell Transwell and WST-1 reagents, we found that microvesicles from pancreatic cancer accelerated migration and proliferation of PANC-1 cells. Meanwhile, the proliferation of these cancer-microvesicle-treated cells (CMTCs) was affected less by 10 μM of gemcitabine relative to healthy microvesicle-treated cells (HMTCs). Next, we optimized the filter-aided sample preparation method to increase the recovery of protein samples and then applied it to the quantification of the proteome of CMTCs and HMTCs. The peptides were labeled and analyzed by liquid chromatography-tandem mass spectrometry. In total, 4102 proteins were identified, where 35 proteins were up-regulated with 27 down-regulated in CMTCs. We verified the quantitative results of three key proteins CD44, PPP2R1A, and TP53 by Western blot. The Ingenuity Pathway Analysis revealed pathways that cancer microvesicles might participate in to promote cell migration and proliferation. These findings may provide novel clues of treatment for tumorigenesis and metastasis.

Quantitative Image Informatics for Cancer Research (QIICR) | Informatics Technology for Cancer Research (ITCR)

Science.gov (United States)

Imaging has enormous untapped potential to improve cancer research through software to extract and process morphometric and functional biomarkers. In the era of non-cytotoxic treatment agents, multi- modality image-guided ablative therapies and rapidly evolving computational resources, quantitative imaging software can be transformative in enabling minimally invasive, objective and reproducible evaluation of cancer treatment response. Post-processing algorithms are integral to high-throughput analysis and fine- grained differentiation of multiple molecular targets.

Electron accelerator technology research in food irradiation

International Nuclear Information System (INIS)

Jin Jianqiao; Ye Mingyang; Zhang Yue; Yang Bin; Xu Tao; Kong Xiangshan

2014-01-01

Electronic accelerator was applied to instead of cobalt sources for food irradiation, to keep food quality and to improve the effect of the treatment. Appropriate accelerator parameters lead to optimal technique. The irradiation effect is associated with the relationship between uniformity and irradiating speed, the effect of cargo size on radiation penetration, as well as other factors that affect the irradiation effects. Industrialization of electron accelerator irradiation will be looked to the future. (authors)

Laser-plasma accelerators, acceleration of particles through laser-matter interaction at ultra-high intensity

International Nuclear Information System (INIS)

Lefebvre, E.

2010-01-01

This series of slides overviews the development of powerful lasers for inertial confinement fusion (Icf) at NIF (National Ignition Facility, Usa) and LMJ (Laser Megajoule, France) facilities. Then the principle of laser wakefield acceleration is presented and the possibility of designing compact accelerators delivering 200 GeV/m while conventional RF accelerators reach only 50 MeV/m, is considered. This technical breakthrough will bring important gains in terms of size, cost and new uses for accelerators. While Icf will use nanosecond (10 -9 s) laser pulses, wakefield accelerators will use femtosecond (10 -15 s) laser pulses which means more power but less energy. The electrons accelerated by laser can produce a multi-MeV X radiation useful for industrial radiography or cancer treatment. (A.C.)

The accelerators of the Joint Institute for Nuclear Research at Dubna

International Nuclear Information System (INIS)

Kuehn, B.

1981-01-01

History, state-of-the-art, and the planned development of the high-energy and heavy-ion accelerators at the Joint Institute for Nuclear Research at Dubna are reviewed. Data on the particle beams available at present and in the future are given. (author)

Experimental research on electromagnetic radiation in inductive energy storage accelerator

International Nuclear Information System (INIS)

Zhong Jianzhong; Liu Lie; Li Limin; Wen Jianchun

2008-01-01

There exists strong electromagnetic radiation in inductive energy storage accelerators. In can destroy a measuring device at a distance. By repeated experiments, we found that it is a wide-spectrum electromagnetic wave with a main frequency of 75 MHz. The effector such as coaxial transmission line is effected strongly in short distance. The current in the coaxial transmission line can be measured in Rogowski coils. The strength of field in it is about 500 V/m and the peak current is 217 mA. The radiation source may be LC oscillating or electric exploding opening switch. Through the experimental research, we think it probably may be caused by the LC oscillating in the circuit when the switches conduct. And its strength is correlated to current change ratio. The change rate in secondary circuit is stronger than in primary circuit. So the radiation generated in secondary circuit is stronger than in primary circuit. It may be a reference for further research in inductive energy storage accelerators and shielding electromagnetic disturbing. (authors)

Hadron accelerators in medicine

International Nuclear Information System (INIS)

Amaldi, U.

1996-01-01

The application of hadron accelerators (protons and light ions) in cancer therapy is discussed. After a brief introduction on the rationale for the use of heavy charged particles in radiation therapy, a discussion is given on accelerator technology and beam delivery systems. Next, existing and planned facilities are briefly reviewed. The Italian Hadron-therapy Project is then described in some detail, with reference ro both the National Centre for Oncological Hadron-therapy and the design of different types of compact proton accelerators aimed at introducing proton therapy in a large umber of hospitals. (author)

PIGMI linear-accelerator technology

International Nuclear Information System (INIS)

Boyd, T.J.; Crandall, K.R.; Hamm, R.W.

1981-01-01

A new linear-accelerator technology has been developed that makes pi-meson (pion) generation possible for cancer therapy in the setting of a major hospital center. This technology uses several new major inventions in particle accelerator science-such as a new accelerator system called the radio-frequency quadrupole (RFQ), and permanent-magnet drift-tube focusing-to substantially reduce the size, cost, and complexity of a meson factory for this use. This paper describes this technology, discusses other possible uses for these new developments, and finally discusses possible costs for such installations

Policy challenges for cancer research: a call to arms.

Science.gov (United States)

Sullivan, R

2007-01-01

Research has delivered remarkable benefits for cancer patients and their families since James Watson and Francis Crick wrote the now immortal line, 'We wish to propose a structure for the salt of deoxyribonucleic acid' thus setting the molecular foundations for the modern era of cancer control. The pace of technological innovation from fundamental scientific discoveries to the policy impact of huge population studies has been breathtaking. One has only to contrast a paper on the treatment of solid epithelial cancers written by Henri Tagnon and colleagues in 1966 (Eur J Cancer2 51-7) with the myriad of chemotherapeutic approaches at the oncologists disposal today. Inevitably, as the tide of research has risen so it has bought the flotsam and jetsam of regulations and policies. Some have been helpful, many pointless and too many actually harmful. Naturally, some of these regulatory and general policies (by this I mean those concerned with funding, structure and organization) have been specifically targeted at cancer research, e.g. US National Cancer Act 1971, whilst others have been a product of the general regulatory environment with indirect consequences for cancer research, e.g. EU Data Protection Directive 1995. Policy issues thus cover a vast terrain criss-crossed by complex interdependencies between scientific areas, countries S&T policies and socio-political constructs. Unfortunately, there has been little attention paid to the consequences of these policy issues from which the research community has, by and large, been passenger rather than driver.Global investment in cancer research is now at unprecedented levels. The recently published report by the European Cancer Research Managers Forum has found some 14 billion euros being annually spent worldwide on cancer research (this figure includes industry but overall probably underestimates spend by at least one billion [2]). With the ageing demographics of developed countries and the catch-up effect in

Heavy-ion fusion accelerator research, 1985

International Nuclear Information System (INIS)

1986-10-01

A plan for exploring the physics and technology of induction linac development is discussed which involves a series of increasingly sophisticated experiments. The first is the single-beam transport experiment, which has explored the physics of a single space-charge-dominated beam. Second is the multiple-beam experiment in which four independent beams will be transported and accelerated through a multigap accelerating structure. The single-beam transport experiment is described, and some results are given of stability studies and instrumentation studies. The design and fabrication of the multi-beam experiment are described, as well as results of a first round of experiments in which beam-current amplification was observed. Concurrent theoretical work, resulting in a variety of acce-leration schedules and sets of associated voltage waveforms required to implement the experiments, is also reported

Nanotechnology in Cancer Research

Science.gov (United States)

The NCI Office of Cancer Nanotechnology Research has had a major impact on bringing novel nano-enabled solutions through the pre-clinical space. The strategic framework of this effort is presented here.

Accelerated Hyperfractionated Radiotherapy for Locally Advanced Uterine Cervix Cancers

International Nuclear Information System (INIS)

Seo, Young Seok; Cho, Chul Koo; Yoo, Seong Yul

2008-01-01

To assess the efficacy of the use of accelerated hyperfractionated radiotherapy (AHRT) for locally advanced uterine cervix cancers. Between May 2000 and September 2002, 179 patients were identified with FIGO stage IIB, IIIB, and IVA cancers. Of the 179 patients, 45 patients were treated with AHRT (AHRT group) and 134 patients were treated with conventional radiotherapy (CRT group), respectively. Patients undergoing the AHRT regimen received a dose of 30 Gy in 20 fractions (1.5 Gyx2 fractions/day) to the whole pelvis. Subsequently, with a midline block, we administered a parametrial boost with a dose of 20 Gy using 2 Gy fractions. Patients also received two courses of low-dose-rate brachytherapy, up to a total dose of 85∼90 Gy to point A. In the CRT group of patients, the total dose to point A was 85∼90 Gy. The overall treatment duration was a median of 37 and 66 days for patients that received AHRT and CRT, respectively. Statistical analysis was calculated by use of the Kaplan-Meier method, the log-rank test, and Chi-squared test. For patients that received cisplatin-based concurrent chemotherapy and radiotherapy, the local control rate at 5 years was 100% and 79.2% for the AHRT and CRT group of patients, respectively (p=0.028). The 5-year survival rate for patients with a stage IIB bulky tumor was 82.6% and 62.1% for the AHRT group and CRT group, respectively (p=0.040). There was no statistically significant difference for severe late toxicity between the two groups (p=0.561). In this study, we observed that treatment with AHRT with concurrent chemotherapy allows a significant advantage of local control and survival for locally advanced uterine cervix cancers

Understanding coping with cancer: how can qualitative research help?

Science.gov (United States)

Chittem, Mahati

2014-01-01

Research in psycho-oncology investigates the psycho-social and emotional aspects of cancer and how this is related to health, well-being and overall patient care. Coping with cancer is a prime focus for researchers owing to its impact on patients' psychological processing and life in general. Research so far has focused mainly on quantitative study designs such as questionnaires to examine the coping strategies used by cancer patients. However, in order to gain a rich and deep understanding of the reasons, processes and types of strategies that patients use to deal with cancer, qualitative study designs are necessary. Few studies have used qualitative designs such as semi-structured interviews to explore coping with cancer. The current paper aims to review the suitability and benefits of using qualitative research designs to understand coping with cancer with the help of some key literature in psycho-oncology research.

Heavy Ion Fusion Accelerator Research (HIFAR) year-end report, April 1--September 30, 1988

International Nuclear Information System (INIS)

1988-12-01

The basic objective of the Heavy Ion Fusion Accelerator Research (HIFAR) program is to assess the suitability of heavy ion accelerators as igniters for Inertial Confinement Fusion (ICF). A specific accelerator technology, the induction linac, has been studied at the Lawrence Berkeley Laboratory and has reached the point at which its viability for ICF applications can be assessed over the next few years. The HIFAR program addresses the generation of high power, high-brightness beams of heavy ions, the understanding of the scaling laws in this novel physics regime, and the validation of new accelerator strategies, to cut costs. Key elements to be addressed include: beam quality limits set by transverse and longitudinal beam physics; development of induction accelerating modules, and multiple-beam hardware, at affordable costs; acceleration of multiple beams with current amplification --both new features in a linac -- without significant dilution of the optical quality of the beams; final bunching, transport, and accurate focusing on a small target

Physics in ;Real Life;: Accelerator-based Research with Undergraduates

Science.gov (United States)

Klay, J. L.

All undergraduates in physics and astronomy should have access to significant research experiences. When given the opportunity to tackle challenging open-ended problems outside the classroom, students build their problem-solving skills in ways that better prepare them for the workplace or future research in graduate school. Accelerator-based research on fundamental nuclear and particle physics can provide a myriad of opportunities for undergraduate involvement in hardware and software development as well as ;big data; analysis. The collaborative nature of large experiments exposes students to scientists of every culture and helps them begin to build their professional network even before they graduate. This paper presents an overview of my experiences - the good, the bad, and the ugly - engaging undergraduates in particle and nuclear physics research at the CERN Large Hadron Collider and the Los Alamos Neutron Science Center.

Heavy Ion Fusion Accelerator Research (HIFAR) year-end report, April 1, 1990--September 30, 1990

International Nuclear Information System (INIS)

1990-12-01

The basic objective of the Heavy Ion Fusion Accelerator Research (HIFAR) program is to assess the suitability of heavy ion accelerators as igniters for Inertial Confinement Fusion (ICF). A specific accelerator technology, induction acceleration, is being studied at the Lawrence Berkeley Laboratory and at the Lawrence Livermore National Laboratory. The HIFAR program addresses the generation of high-power, high-brightness beams of heavy ions, the understanding of the scaling laws in this novel physics regime, and the validation of new accelerator strategies to cut costs. Key elements to be addressed include: (1) beam quality limits set by transverse and longitudinal beam physics; (2) development of induction accelerating modules, and multiple-beam hardware, at affordable costs; (3) acceleration of multiple beams with current amplification without significant dilution of the optical quality of the beams; (4) final bunching, transport, and accurate focusing on a small target

Bioinspired Hydrogels to Engineer Cancer Microenvironments.

Science.gov (United States)

Park, Kyung Min; Lewis, Daniel; Gerecht, Sharon

2017-06-21

Recent research has demonstrated that tumor microenvironments play pivotal roles in tumor development and metastasis through various physical, chemical, and biological factors, including extracellular matrix (ECM) composition, matrix remodeling, oxygen tension, pH, cytokines, and matrix stiffness. An emerging trend in cancer research involves the creation of engineered three-dimensional tumor models using bioinspired hydrogels that accurately recapitulate the native tumor microenvironment. With recent advances in materials engineering, many researchers are developing engineered tumor models, which are promising platforms for the study of cancer biology and for screening of therapeutic agents for better clinical outcomes. In this review, we discuss the development and use of polymeric hydrogel materials to engineer native tumor ECMs for cancer research, focusing on emerging technologies in cancer engineering that aim to accelerate clinical outcomes.

Biomedical text mining and its applications in cancer research.

Science.gov (United States)

Zhu, Fei; Patumcharoenpol, Preecha; Zhang, Cheng; Yang, Yang; Chan, Jonathan; Meechai, Asawin; Vongsangnak, Wanwipa; Shen, Bairong

2013-04-01

Cancer is a malignant disease that has caused millions of human deaths. Its study has a long history of well over 100years. There have been an enormous number of publications on cancer research. This integrated but unstructured biomedical text is of great value for cancer diagnostics, treatment, and prevention. The immense body and rapid growth of biomedical text on cancer has led to the appearance of a large number of text mining techniques aimed at extracting novel knowledge from scientific text. Biomedical text mining on cancer research is computationally automatic and high-throughput in nature. However, it is error-prone due to the complexity of natural language processing. In this review, we introduce the basic concepts underlying text mining and examine some frequently used algorithms, tools, and data sets, as well as assessing how much these algorithms have been utilized. We then discuss the current state-of-the-art text mining applications in cancer research and we also provide some resources for cancer text mining. With the development of systems biology, researchers tend to understand complex biomedical systems from a systems biology viewpoint. Thus, the full utilization of text mining to facilitate cancer systems biology research is fast becoming a major concern. To address this issue, we describe the general workflow of text mining in cancer systems biology and each phase of the workflow. We hope that this review can (i) provide a useful overview of the current work of this field; (ii) help researchers to choose text mining tools and datasets; and (iii) highlight how to apply text mining to assist cancer systems biology research. Copyright © 2012 Elsevier Inc. All rights reserved.

Relativistic klystron research for high gradient accelerators

International Nuclear Information System (INIS)

Allen, M.A.; Callin, R.S.; Deruyter, H.

1988-06-01

Relativistic klystrons are being developed as a power source for high gradient accelerator applications which include large linear electron--positron colliders, compact accelerators, and FEL sources. We have attained 200MW peak power at 11.4 GHz from a relativistic klystron, and 140 MV/m longitudinal gradient in a short 11.4 GHz accelerator section. We report here on the design of our first klystrons, the results of our experiments so far, and some of our plans for the near future. 5 refs., 7 figs

Industrial Application of Accelerators

CERN Multimedia

CERN. Geneva

2017-01-01

At CERN, we are very familiar with large, high energy particle accelerators. However, in the world outside CERN, there are more than 35000 accelerators which are used for applications ranging from treating cancer, through making better electronics to removing harmful micro-organisms from food and water. These are responsible for around $0.5T of commerce each year. Almost all are less than 20 MeV and most use accelerator types that are somewhat different from what is at CERN. These lectures will describe some of the most common applications, some of the newer applications in development and the accelerator technology used for them. It will also show examples of where technology developed for particle physics is now being studied for these applications. Rob Edgecock is a Professor of Accelerator Science, with a particular interest in the medical applications of accelerators. He works jointly for the STFC Rutherford Appleton Laboratory and the International Institute for Accelerator Applications at the Univer...

Industrial Application of Accelerators

CERN Multimedia

CERN. Geneva

2017-01-01

At CERN, we are very familiar with large, high energy particle accelerators. However, in the world outside CERN, there are more than 35000 accelerators which are used for applications ranging from treating cancer, through making better electronics to removing harmful micro-organisms from food and water. These are responsible for around $0.5T of commerce each year. Almost all are less than 20 MeV and most use accelerator types that are somewhat different from what is at CERN. These lectures will describe some of the most common applications, some of the newer applications in development and the accelerator technology used for them. It will also show examples of where technology developed for particle physics is now being studied for these applications. Rob Edgecock is a Professor of Accelerator Science, with a particular interest in the medical applications of accelerators. He works jointly for the STFC Rutherford Appleton Laboratory and the International Institute for Accelerator Applications at the Uni...

ELECTROMAGNETIC SIMULATIONS OF LINEAR PROTON ACCELERATOR STRUCTURES USING DIELECTRIC WALL ACCELERATORS

International Nuclear Information System (INIS)

Nelson, S; Poole, B; Caporaso, G

2007-01-01

Proton accelerator structures for medical applications using Dielectric Wall Accelerator (DWA) technology allow for the utilization of high electric field gradients on the order of 100 MV/m to accelerate the proton bunch. Medical applications involving cancer therapy treatment usually desire short bunch lengths on the order of hundreds of picoseconds in order to limit the extent of the energy deposited in the tumor site (in 3D space, time, and deposited proton charge). Electromagnetic simulations of the DWA structure, in combination with injections of proton bunches have been performed using 3D finite difference codes in combination with particle pushing codes. Electromagnetic simulations of DWA structures includes these effects and also include the details of the switch configuration and how that switch time affects the electric field pulse which accelerates the particle beam

Recircular accelerator to proton ocular therapy

International Nuclear Information System (INIS)

Rabelo, Luisa A.; Campos, Tarcisio P.R.

2013-01-01

Proton therapy has been used for the treatment of Ocular Tumors, showing control in most cases as well as conservation of the eyeball, avoiding the enucleation. The protons provide higher energetic deposition in depth with reduced lateral spread, compared to the beam of photons and electrons, with characteristic dose deposition peak (Bragg peak). This technique requires large particle accelerators hampering the deployment a Proton Therapy Center in some countries due to the need for an investment of millions of dollars. This study is related to a new project of an electromagnetic unit of proton circular accelerator to be coupled to the national radiopharmaceutical production cyclotrons, to attend ocular therapy. This project evaluated physical parameters of proton beam circulating through classical and relativistic mechanical formulations and simulations based on an ion transport code in electromagnetic fields namely CST (Computer Simulation Technology). The structure is differentiated from other circular accelerations (patent CTIT/UFMG NRI research group/UFMG). The results show the feasibility of developing compact proton therapy equipment that works like pre-accelerator or post-accelerator to cyclotrons, satisfying the interval energy of 15 MeV to 64 MeV. Methods of reducing costs of manufacture, installation and operation of this equipment will facilitate the dissemination of the proton treatment in Brazil and consequently advances in fighting cancer. (author)

Recircular accelerator to proton ocular therapy

Energy Technology Data Exchange (ETDEWEB)

Rabelo, Luisa A.; Campos, Tarcisio P.R., E-mail: luisarabelo88@gmail.com, E-mail: tprcampos@pq.cnpq.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear

2013-07-01

Proton therapy has been used for the treatment of Ocular Tumors, showing control in most cases as well as conservation of the eyeball, avoiding the enucleation. The protons provide higher energetic deposition in depth with reduced lateral spread, compared to the beam of photons and electrons, with characteristic dose deposition peak (Bragg peak). This technique requires large particle accelerators hampering the deployment a Proton Therapy Center in some countries due to the need for an investment of millions of dollars. This study is related to a new project of an electromagnetic unit of proton circular accelerator to be coupled to the national radiopharmaceutical production cyclotrons, to attend ocular therapy. This project evaluated physical parameters of proton beam circulating through classical and relativistic mechanical formulations and simulations based on an ion transport code in electromagnetic fields namely CST (Computer Simulation Technology). The structure is differentiated from other circular accelerations (patent CTIT/UFMG NRI research group/UFMG). The results show the feasibility of developing compact proton therapy equipment that works like pre-accelerator or post-accelerator to cyclotrons, satisfying the interval energy of 15 MeV to 64 MeV. Methods of reducing costs of manufacture, installation and operation of this equipment will facilitate the dissemination of the proton treatment in Brazil and consequently advances in fighting cancer. (author)

Medical Proton Accelerator Project

International Nuclear Information System (INIS)

Comsan, M.N.H.

2008-01-01

A project for a medical proton accelerator for cancer treatment is outlined. The project is motivated by the need for a precise modality for cancer curing especially in children. Proton therapy is known by its superior radiation and biological effectiveness as compared to photon or electron therapy. With 26 proton and 3 heavy-ion therapy complexes operating worldwide only one (p) exists in South Africa, and none in south Asia and the Middle East. The accelerator of choice should provide protons with energy 75 MeV for eye treatment and 250 MeV for body treatment. Four treatment rooms are suggested: two with isocentric gantries, one with fixed beams and one for development. Passive scanning is recommended. The project can serve Middle East and North Africa with ∼ 400 million populations. The annual capacity of the project is estimated as 1,100 to be compared with expected radiation cases eligible for proton cancer treatment of not less than 200,000

Advanced research on separating prostate cancer stem cells

International Nuclear Information System (INIS)

Hao Yumei; He Xin; Song Naling

2013-01-01

Prostate cancer is a common malignant tumor in male urinary system,and may easily develop into the hormone refractory prostate cancer which can hardly be cured. Recent studies had found that the prostate cancer stem cells may be the source of the prostate cancer's occurrence,development, metastasis and recurrence. The therapy targeting the prostate cancer stem cells may be the effective way to cure prostate cancer. But these cells is too low to be detected. The difficulty lies in the low separation efficiency of prostate cancer stem cell, so the effectively separating prostate cancer stem cells occupied the main position for the more in-depth research of prostate cancer stem cells. This paper reviews the research progress and existing problems on the several main separating methods of prostate cancer stem cells, includes the fluorescence activated cells sorting and magnetic activated cells sorting based on prostate cancer stem cell surface markers, the side-population sorting and serum-free medium sphere forming sorting based on prostate cancer stem cell's biology. (authors)

DOE Research Contributions to Radiation and Cancer Therapy

Science.gov (United States)

dropdown arrow Site Map A-Z Index Menu Synopsis DOE Research Contributions to Radiation and Cancer Therapy Possible: DOE Advanced Biomedical Technology Research, page 10 Over the time span of many years, DOE's research has made many contributions to radiation and cancer therapy, including PEREGRINE and Boron Neutron

Research of accelerator-based neutron source for boron neutron capture therapy

International Nuclear Information System (INIS)

Li Changkai; Ma Yingjie; Tang Xiaobin; Xie Qin; Geng Changran; Chen Da

2013-01-01

Background: 7 Li (p, n) reaction of high neutron yield and low threshold energy has become one of the most important neutron generating reactions for Accelerator-based Boron Neutron Capture Therapy (BNCT). Purpose Focuses on neutron yield and spectrum characteristics of this kind of neutron generating reaction which serves as an accelerator-based neutron source and moderates the high energy neutron beams to meet BNCT requirements. Methods: The yield and energy spectrum of neutrons generated by accelerator-based 7 Li(p, n) reaction with incident proton energy from 1.9 MeV to 3.0 MeV are researched using the Monte Carlo code-MCNPX2.5.0. And the energy and angular distribution of differential neutron yield by 2.5-MeV incident proton are also given in this part. In the following part, the character of epithermal neutron beam generated by 2.5-MeV incident protons is moderated by a new-designed moderator. Results: Energy spectra of neutrons generated by accelerator-based 7 Li(p, n) reaction with incident proton energy from 1.9 MeV to 3.0 MeV are got through the simulation and calculation. The best moderator thickness is got through comparison. Conclusions: Neutron beam produced by accelerator-based 7 Li(p, n) reaction, with the bombarding beam of 10 mA and the energy of 2.5 MeV, can meet the requirement of BNCT well after being moderated. (authors)

Hardware dependencies of GPU-accelerated beamformer performances for microwave breast cancer detection

Directory of Open Access Journals (Sweden)

Salomon Christoph J.

2016-09-01

Full Text Available UWB microwave imaging has proven to be a promising technique for early-stage breast cancer detection. The extensive image reconstruction time can be accelerated by parallelizing the execution of the underlying beamforming algorithms. However, the efficiency of the parallelization will most likely depend on the grade of parallelism of the imaging algorithm and of the utilized hardware. This paper investigates the dependencies of two different beamforming algorithms on multiple hardware specification of several graphics boards. The parallel implementation is realized by using NVIDIA’s CUDA. Three conclusions are drawn about the behavior of the parallel implementation and how to efficiently use the accessible hardware.

A Milestone in Cancer Research and Treatment in India

Science.gov (United States)

Tata Memorial Center is celebrating 75 years of leadership service towards cancer control and research in India. In honor of this anniversary, TMC is hosting A Conference of New Ideas in Cancer – Challenging Dogmas on February 26-28th, 2016 as part of its platinum jubilee events. CGH Director, Dr. Ted Trimble, will give a plenary talk: "Thinking Outside the Box in Cancer Research - Perspectives from the US NCI” in the session titled: Future of Cancer Research: US and European perspectives.

Current status of neutron scattering research and accelerator technology in Indonesia

International Nuclear Information System (INIS)

Ridwan; Ikram, Abarul; Wuryanto

2001-01-01

The neutron beam generated from steady state reactor 30 MW RSG-GAS are used mainly for neutron scattering studies and isotope production. There are seven neutron scattering facilities under responsible and operated by Research and Development Center for Materials Science and Technology of National Nuclear Energy Agency (Batan) of Indonesia. In this report, current conditions of the facilities namely, DN1-M, HRPD, FCD/TD, SANS, HRSANS, TAS and NRF and research activities will be described. Also, a part of research activities by using accelerator technology at Batan-Yogyakarta will be reviewed. (author)

Selected works of basic research on the physics and technology of accelerator driven clean nuclear power system

International Nuclear Information System (INIS)

Zhao Zhixiang

2002-01-01

38 theses are presented in this selected works of basic research on the physics and technology of accelerator driven clean nuclear power system. It includes reactor physics and experiment, accelerators physics and technology, nuclear physics, material research and partitioning. 13 abstracts, which has been presented on magazines home and abroad, are collected in the appendix

Laboratory Animal Technician | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused

Accelerators in Science and Technology

CERN Document Server

Kailas, S

2002-01-01

Accelerators built for basic research in frontier areas of science have become important and inevitable tools in many areas of science and technology. Accelerators are examples of science driven high technology development. Accelerators are used for a wide ranging applications, besides basic research. Accelerator based multidisciplinary research holds great promise

Mexican breast cancer research output, 2003-2012.

Science.gov (United States)

Perez-Santos, Jose Luis Martin; Anaya-Ruiz, Maricruz

2013-01-01

The objetive of this study was to explore a bibliometric approach to quantitatively assess current research trends with regard to breast cancer in Mexico. Articles were analyzed by scientific output and research performances of individuals, institutes, and collaborative countries with Mexico. Data were retrieved from the Web of Science database from 2003 to 2012; this was searched using different terms related to breast cancer, including "breast cancer", "mammary ductal carcinoma" and "breast tumour". Data were then extracted from each file, transferred to Excel charts and visualised as diagrams. A total of 256 articles were retrieved. The institutions with the majority of publications were the National Autonomous University of Mexico (22.3%), the National Institute of Cancerology (21.9%), and Social Security Mexican Institute (20.3%); clinical observation studies were the dominant investigation type (64%), and the main types of research were metabolics (24.2%) and pathology (21.5%). This article demonstrates the usefulness of bibliometrics to address key evaluation questions and to establish priorities, define future areas of research, and develop breast cancer control strategies in Mexico.

The research status of induced radioactivity in accelerator facilities

International Nuclear Information System (INIS)

Lu Feng; Deng Daping

2005-01-01

The hazards of subsequent-radiation produced by high-energy accelerator must be no ignore. The principle of induced radioactivity and the hazards to the people were introduced in this article. The radiation levels around the treatment head and in the air of the treatment room were discussed thor-oughly. Some effects of the induced radioactivity were also mentioned. At last, the article talks about some problems in present researches and some directions for the following study. (authors)

Accelerator research studies. Progress report

International Nuclear Information System (INIS)

1983-07-01

The major goal of this project is to study the effects that lead to emittance growth and limitation of beam current and brightness in periodic focusing systems (including linear accelerators). This problem is of great importance for all accelerator applications requiring high intensity beams with small emittance such as heavy ion fusion, spallation neutron sources and high energy physics. In the latter case, future machines must not only provide higher energies (in the range of 10 to 100 TeV), but also higher luminosities than the existing facilities. This implies considerably higher phase-space density of the particle beam produced by the injector linac, i.e., the detrimental emittance growth and concurrent beam loss observed in existing linacs must be avoided

Cancer Research Participation Beliefs and Behaviors of a Southern Black Population: A Quantitative Analysis of the Role of Structural Factors in Cancer Research Participation.

Science.gov (United States)

Farr, Deeonna E; Brandt, Heather M; Comer, Kimberly D; Jackson, Dawnyéa D; Pandya, Kinjal; Friedman, Daniela B; Ureda, John R; Williams, Deloris G; Scott, Dolores B; Green, Wanda; Hébert, James R

2015-09-01

Increasing the participation of Blacks in cancer research is a vital component of a strategy to reduce racial inequities in cancer burden. Community-based participatory research (CBPR) is especially well-suited to advancing our knowledge of factors that influence research participation to ultimately address cancer-related health inequities. A paucity of literature focuses on the role of structural factors limiting participation in cancer research. As part of a larger CBPR project, we used survey data from a statewide cancer needs assessment of a Black faith community to examine the influence of structural factors on attitudes toward research and the contributions of both structural and attitudinal factors on whether individuals participate in research. Regression analyses and non-parametric statistics were conducted on data from 727 adult survey respondents. Structural factors, such as having health insurance coverage, experiencing discrimination during health care encounters, and locale, predicted belief in the benefits, but not the risks, of research participation. Positive attitudes toward research predicted intention to participate in cancer research. Significant differences in structural and attitudinal factors were found between cancer research participants and non-participants; however, directionality is confounded by the cross-sectional survey design and causality cannot be determined. This study points to complex interplay of structural and attitudinal factors on research participation as well as need for additional quantitative examinations of the various types of factors that influence research participation in Black communities.

Big Data-Led Cancer Research, Application, and Insights.

Science.gov (United States)

Brown, James A L; Ni Chonghaile, Triona; Matchett, Kyle B; Lynam-Lennon, Niamh; Kiely, Patrick A

2016-11-01

Insights distilled from integrating multiple big-data or "omic" datasets have revealed functional hierarchies of molecular networks driving tumorigenesis and modifiers of treatment response. Identifying these novel key regulatory and dysregulated elements is now informing personalized medicine. Crucially, although there are many advantages to this approach, there are several key considerations to address. Here, we examine how this big data-led approach is impacting many diverse areas of cancer research, through review of the key presentations given at the Irish Association for Cancer Research Meeting and importantly how the results may be applied to positively affect patient outcomes. Cancer Res; 76(21); 6167-70. ©2016 AACR. ©2016 American Association for Cancer Research.

Research on cw electron accelerators using room-temperature rf structures. Annual report

International Nuclear Information System (INIS)

1985-01-01

Highlights reported include: measurement of the 100 keV chopped beam emittance, completion of installation of the entire 5 MeV injector linac system with all rf power and drive, extensive field mapping of one end magnet, completion of construction of the 12 MeV linac for the racetrack microtron (RTM), installation of most of the control system, and first acceleration of beam to 5 MeV. Plans for completion of the project are discussed. When the RTM is operating, it is expected to have many unique performance characteristics, including the cw nature of the beam, high current, easily variable energy over a wide range, excellent emittance, and small energy spread. Plans for future uses in the areas of nuclear physics, dosimetry research and standards, accelerator development, and free electron laser research are discussed. 19 refs

Advanced Accelerators for Medical Applications

Science.gov (United States)

Uesaka, Mitsuru; Koyama, Kazuyoshi

We review advanced accelerators for medical applications with respect to the following key technologies: (i) higher RF electron linear accelerator (hereafter “linac”); (ii) optimization of alignment for the proton linac, cyclotron and synchrotron; (iii) superconducting magnet; (iv) laser technology. Advanced accelerators for medical applications are categorized into two groups. The first group consists of compact medical linacs with high RF, cyclotrons and synchrotrons downsized by optimization of alignment and superconducting magnets. The second group comprises laser-based acceleration systems aimed of medical applications in the future. Laser plasma electron/ion accelerating systems for cancer therapy and laser dielectric accelerating systems for radiation biology are mentioned. Since the second group has important potential for a compact system, the current status of the established energy and intensity and of the required stability are given.

Understanding participation by African Americans in cancer genetics research.

Science.gov (United States)

McDonald, Jasmine A; Barg, Frances K; Weathers, Benita; Guerra, Carmen E; Troxel, Andrea B; Domchek, Susan; Bowen, Deborah; Shea, Judy A; Halbert, Chanita Hughes

2012-01-01

Understanding genetic factors that contribute to racial differences in cancer outcomes may reduce racial disparities in cancer morbidity and mortality. Achieving this goal will be limited by low rates of African American participation in cancer genetics research. We conducted a qualitative study with African American adults (n = 91) to understand attitudes about participating in cancer genetics research and to identify factors that are considered when making a decision about participating in this type of research. Participants would consider the potential benefits to themselves, family members, and their community when making a decision to participate in cancer genetics research. However, concerns about exploitation, distrust of researchers, and investigators' motives were also important to participation decisions. Individuals would also consider who has access to their personal information and what would happen to these data. Side effects, logistical issues, and the potential to gain knowledge about health issues were also described as important factors in decision making. African Americans may consider a number of ethical, legal, and social issues when making a decision to participate in cancer genetics research. These issues should be addressed as part of recruitment efforts.

Obesity-Linked Mouse Models of Liver Cancer | Center for Cancer Research

Science.gov (United States)

Jimmy Stauffer, Ph.D., and colleagues working with Robert  Wiltrout, Ph.D., in CCR’s Cancer and Inflammation Program, along with collaborators in the Laboratory of Human Carcinogenesis, have developed a novel mouse model that demonstrates how fat-producing phenotypes can influence the development of hepatic cancer.   The team recently reported their findings in Cancer Research.

Application of accelerated failure time models for breast cancer patients' survival in Kurdistan Province of Iran.

Science.gov (United States)

Karimi, Asrin; Delpisheh, Ali; Sayehmiri, Kourosh

2016-01-01

Breast cancer is the most common cancer and the second common cause of cancer-induced mortalities in Iranian women. There has been a rapid development in hazard models and survival analysis in the last decade. The aim of this study was to evaluate the prognostic factors of overall survival (OS) in breast cancer patients using accelerated failure time models (AFT). This was a retrospective-analytic cohort study. About 313 women with a pathologically proven diagnosis of breast cancer who had been treated during a 7-year period (since January 2006 until March 2014) in Sanandaj City, Kurdistan Province of Iran were recruited. Performance among AFT was assessed using the goodness of fit methods. Discrimination among the exponential, Weibull, generalized gamma, log-logistic, and log-normal distributions was done using Akaik information criteria and maximum likelihood. The 5 years OS was 75% (95% CI = 74.57-75.43). The main results in terms of survival were found for the different categories of the clinical stage covariate, tumor metastasis, and relapse of cancer. Survival time in breast cancer patients without tumor metastasis and relapse were 4, 2-fold longer than other patients with metastasis and relapse, respectively. One of the most important undermining prognostic factors in breast cancer is metastasis; hence, knowledge of the mechanisms of metastasis is necessary to prevent it so occurrence and treatment of metastatic breast cancer and ultimately extend the lifetime of patients.

The South African National Accelerator Centre and its research programme

Energy Technology Data Exchange (ETDEWEB)

Watanabe, Y. [Kyushu Univ., Fukuoka (Japan)

1997-03-01

An overview of the South African National Accelerator Centre and its research activities is given with emphasis on medium energy nuclear physics and nuclear data measurements for medical use. Also presented is a preliminary result of {sup 40}Ca(p,p`x) spectrum measurement for 392 MeV which has been carried out at RCNP, Osaka University, under the South Africa-Japan collaborative programme. (author)

Adoptive Cell Therapies: One Cancer at a Time | Center for Cancer Research

Science.gov (United States)

After completing medical school and a general surgery residency at the University of Missouri, Kansas City, Christian Hinrichs, M.D., planned on doing cancer research at the start of his fellowship at Roswell Park Cancer Institute in 1996. However, a detour sent him into surgical oncology, and Hinrichs only returned to his research interests through a subsequent surgical

Accelerated fractionation in cancers of the esophagus: a multivariate analysis on 102 patients

International Nuclear Information System (INIS)

Girinsky, T.; Marsiglia, H.; Auperin, A.

1995-01-01

Purpose: Clinical outcome of cancer of the esophagus treated with conventional fractionated radiotherapy is dismal. Locoregional recurrences remain a major unresolved issue. Although data are scarce, potential doubling times of the squamous cell carcinoma of the esophagus appear to be generally rather short. Accelerated fractionation was used to shorten the conventional overall treatment time by two and half weeks (38% reduction of the treatment time) to counteract possible tumor cell repopulation. Materials and Methods: 102 patients with cancer of the esophagus not submitted to surgery for medical reasons or because of extensive disease. (locoregional or metastases) were entered in the study between 1986 and 1993. There were 27T1, 36T2 and 39T3 tumors, 10% of which were already metastatic. 89% of the patients had a squamous cell carcinoma and 11% an adenocarcinoma. Loss of weight about superior or equal to 10% occurred in 39% of the patients. In 63% of the cases neoadjuvant chemotherapy was given prior to radiation treatment. Radiation treatment delivered a mean dose of 66 Gy (SE=6.4), median dose of 65 Gy. The mean overall treatment time was 32.6 days (SE=6.2), median 31 days. A concomitant boost was used during the basic wide field irradiation to accelerate treatment. Results: Acute toxicity was mainly esophageal. Esophagitis grade III was observed in 17% of the patients and lasted 2 to 3 weeks. Radiation treatment was temporarily stopped in 8% of the patients due to esophagitis and was usually resumed a week later. Previous chemotherapy did not seem to significantly increase the occurrence of esophagitis. Of 82 evaluable patients, 56% had complete tumor regression 2 to 4 months after radiation treatment. There was no strict correlation between response after chemotherapy and the subsequent response after radiotherapy. The actuarial 3-year cause specific survival rates for T1, T2, T3 are 34%, 18.5% and 5% respectively. The actuarial 3-year local control rates

Accelerated fractionation in cancers of the esophagus: a multivariate analysis on 102 patients

Energy Technology Data Exchange (ETDEWEB)

Girinsky, T; Marsiglia, H; Auperin, A

1995-07-01

Purpose: Clinical outcome of cancer of the esophagus treated with conventional fractionated radiotherapy is dismal. Locoregional recurrences remain a major unresolved issue. Although data are scarce, potential doubling times of the squamous cell carcinoma of the esophagus appear to be generally rather short. Accelerated fractionation was used to shorten the conventional overall treatment time by two and half weeks (38% reduction of the treatment time) to counteract possible tumor cell repopulation. Materials and Methods: 102 patients with cancer of the esophagus not submitted to surgery for medical reasons or because of extensive disease. (locoregional or metastases) were entered in the study between 1986 and 1993. There were 27T1, 36T2 and 39T3 tumors, 10% of which were already metastatic. 89% of the patients had a squamous cell carcinoma and 11% an adenocarcinoma. Loss of weight about superior or equal to 10% occurred in 39% of the patients. In 63% of the cases neoadjuvant chemotherapy was given prior to radiation treatment. Radiation treatment delivered a mean dose of 66 Gy (SE=6.4), median dose of 65 Gy. The mean overall treatment time was 32.6 days (SE=6.2), median 31 days. A concomitant boost was used during the basic wide field irradiation to accelerate treatment. Results: Acute toxicity was mainly esophageal. Esophagitis grade III was observed in 17% of the patients and lasted 2 to 3 weeks. Radiation treatment was temporarily stopped in 8% of the patients due to esophagitis and was usually resumed a week later. Previous chemotherapy did not seem to significantly increase the occurrence of esophagitis. Of 82 evaluable patients, 56% had complete tumor regression 2 to 4 months after radiation treatment. There was no strict correlation between response after chemotherapy and the subsequent response after radiotherapy. The actuarial 3-year cause specific survival rates for T1, T2, T3 are 34%, 18.5% and 5% respectively. The actuarial 3-year local control rates

Shielding considerations for an electron linear accelerator complex for high energy physics and photonics research

International Nuclear Information System (INIS)

Holmes, J.A.; Huntzinger, C.J.

1987-01-01

Radiation shielding considerations for a major high-energy physics and photonics research complex which comprise a 50 MeV electron linear accelerator injector, a 1.0 GeV electron linear accelerator and a 1.3 GeV storage ring are discussed. The facilities will be unique because of the close proximity of personnel to the accelerator beam lines, the need to adapt existing facilities and shielding materials and the application of strict ALARA dose guidelines while providing maximum access and flexibility during a phased construction program

Project of compact accelerator for cancer proton therapy

International Nuclear Information System (INIS)

Picardi, L.; Ronsivalle, C.; Vignati, A.

1995-04-01

The status of the sub-projetc 'Compact Accelerator' in the framework of the Hadrontherapy Project leaded by Prof. Amaldi is described. Emphasis is given to the reasons of the use of protons for radiotherapy applications, to the results of the preliminary design studies of four types of accelerators as possible radiotherapy dedicated 'Compact Accelerator' and to the scenario of the fonts of financial resources

Discontinuous Schedule of Bevacizumab in Colorectal Cancer Induces Accelerated Tumor Growth and Phenotypic Changes

Directory of Open Access Journals (Sweden)

Selma Becherirat

2018-04-01

Full Text Available Antiangiogenics administration in colorectal cancer patients seemed promising therapeutic approach. Inspite of early encouraging results, it however gave only modest clinical benefits. When AAG was administered with discontinuous schedule, the disease showed acceleration in certain cases. Though resistance to AAG has been extensively studied, it is not documented for discontinuous schedules. To simulate clinical situations, we subjected a patient-derived CRC subcutaneous xenograft in mice to three different protocols: 1 AAG (bevacizumab treatment for 30 days (group A (group B was the control, 2 bevacizumab treatment for 50 days (group C and bevacizumab for 30 days and 20 without treatment (group D, and 3 bevacizumab treatment for 70 days (group E and 70 days treatment with a drug-break period between day 30 and 50 (group F. The tumor growth was monitored, and at sacrifice, the vascularity of tumors was measured and the proangiogenic factors quantified. Tumor phenotype was studied by quantifying cancer stem cells. Interrupting bevacizumab during treatment accelerated tumor growth and revascularization. A significant increase of proangiogenic factors was observed when therapy was stopped. On withdrawal of bevacizumab, as also after the drug-break period, the plasmatic VEGF increased significantly. Similarly, a notable increase of CSCs after the withdrawal and drug-break period of bevacizumab was observed (P<.01. The present study indicates that bevacizumab treatment needs to be maintained because discontinuous schedules tend to trigger tumor regrowth, and increase tumor resistance and CSC heterogeneity.

Using Mechanical Turk for research on cancer survivors.

Science.gov (United States)

Arch, Joanna J; Carr, Alaina L

2017-10-01

The successful recruitment and study of cancer survivors within psycho-oncology research can be challenging, time-consuming, and expensive, particularly for key subgroups such as young adult cancer survivors. Online crowdsourcing platforms offer a potential solution that has not yet been investigated with regard to cancer populations. The current study assessed the presence of cancer survivors on Amazon's Mechanical Turk (MTurk) and the feasibility of using MTurk as an efficient, cost-effective, and reliable psycho-oncology recruitment and research platform. During a <4-month period, cancer survivors living in the United States were recruited on MTurk to complete two assessments, spaced 1 week apart, relating to psychosocial and cancer-related functioning. The reliability and validity of responses were investigated. Within a <4-month period, 464 self-identified cancer survivors on MTurk consented to and completed an online assessment. The vast majority (79.09%) provided reliable and valid study data according to multiple indices. The sample was highly diverse in terms of U.S. geography, socioeconomic status, and cancer type, and reflected a particularly strong presence of distressed and young adult cancer survivors (median age = 36 years). A majority of participants (58.19%) responded to a second survey sent one week later. Online crowdsourcing represents a feasible, efficient, and cost-effective recruitment and research platform for cancer survivors, particularly for young adult cancer survivors and those with significant distress. We discuss remaining challenges and future recommendations. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Electrical Engineering in Los Alamos Neutron Science Center Accelerator

Energy Technology Data Exchange (ETDEWEB)

Silva, Michael James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-11-30

The field of electrical engineering plays a significant role in particle accelerator design and operations. Los Alamos National Laboratories LANSCE facility utilizes the electrical energy concepts of power distribution, plasma generation, radio frequency energy, electrostatic acceleration, signals and diagnostics. The culmination of these fields produces a machine of incredible potential with uses such as isotope production, neutron spallation, neutron imaging and particle analysis. The key isotope produced in LANSCE isotope production facility is Strontium-82 which is utilized for medical uses such as cancer treatment and positron emission tomography also known as PET scans. Neutron spallation is one of the very few methods used to produce neutrons for scientific research the other methods are natural decay of transuranic elements from nuclear reactors. Accelerator produce neutrons by accelerating charged particles into neutron dense elements such as tungsten imparting a neutral particle with kinetic energy, this has the benefit of producing a large number of neutrons as well as minimizing the waste generated. Utilizing the accelerator scientist can gain an understanding of how various particles behave and interact with matter to better understand the natural laws of physics and the universe around us.

Heavy Ion Fusion Accelerator Research (HIFAR) half-year report, October 1, 1988--March 31, 1989

International Nuclear Information System (INIS)

1989-06-01

The basic objective of the Heavy Ion Fusion Accelerator Research (HIFAR) program is to assess the suitability of heavy ion accelerators as igniters for Inertial Confinement Fusion (ICF). A specific accelerator technology, the induction linac, has been studied at the Lawrence Berkeley Laboratory and has reached the point at which its viability for ICF applications can be assessed over the next few years. The HIFAR program addresses the generation of high-power, high-brightness beams of heavy ions, the understanding of the scaling laws in this novel physics regime, and the validation of new accelerator strategies, to cut costs. Key elements to be addressed include: beam quality limits set by transverse and longitudinal beam physics; development of induction accelerating modules, and multiple-beam hardware, at affordable costs; acceleration of multiple beams with current amplification --both new features in a linac -- without significant dilution of the optical quality of the beams; and final bunching, transport, and accurate focusing on a small target

Heavy Ion Fusion Accelerator Research (HIFAR) year-end report, October 1, 1987--March 31, 1988

International Nuclear Information System (INIS)

1988-06-01

The basic objective of the Heavy Ion Fusion Accelerator Research (HIFAR) program is to assess the suitability of heavy ion accelerators as igniters for Inertial Confinement Fusion (ICF). A specific accelerator technology, the induction linac, has been studied at Lawrence Berkeley Laboratory and has reached the point at which its viability for ICF applications can be assessed over the next few years. The HIFAR program addresses the generation of high-power, high-brightness beams of heavy ions, the understanding of the scaling laws in this novel physics regime, and the validation of new accelerator strategies, to cut costs. Key elements to be addressed include: beam quality limits set by transverse and longitudinal beam physics; development of induction accelerating modules, and multiple-beam hardware, at affordable costs; acceleration of multiple beams with current amplification -- both new features in a linac -- without significant dilution of the optical quality of beams; and final bunching, transport, and accurate focusing on a small target

Building capacity for sustainable research programmes for cancer in Africa.

Science.gov (United States)

Adewole, Isaac; Martin, Damali N; Williams, Makeda J; Adebamowo, Clement; Bhatia, Kishor; Berling, Christine; Casper, Corey; Elshamy, Karima; Elzawawy, Ahmed; Lawlor, Rita T; Legood, Rosa; Mbulaiteye, Sam M; Odedina, Folakemi T; Olopade, Olufunmilayo I; Olopade, Christopher O; Parkin, Donald M; Rebbeck, Timothy R; Ross, Hana; Santini, Luiz A; Torode, Julie; Trimble, Edward L; Wild, Christopher P; Young, Annie M; Kerr, David J

2014-05-01

Cancer research in Africa will have a pivotal role in cancer control planning in this continent. However, environments (such as those in academic or clinical settings) with limited research infrastructure (laboratories, biorespositories, databases) coupled with inadequate funding and other resources have hampered African scientists from carrying out rigorous research. In September 2012, over 100 scientists with expertise in cancer research in Africa met in London to discuss the challenges in performing high-quality research, and to formulate the next steps for building sustainable, comprehensive and multi-disciplinary programmes relevant to Africa. This was the first meeting among five major organizations: the African Organisation for Research and Training in Africa (AORTIC), the Africa Oxford Cancer Foundation (AfrOx), and the National Cancer Institutes (NCI) of Brazil, France and the USA. This article summarizes the discussions and recommendations of this meeting, including the next steps required to create sustainable and impactful research programmes that will enable evidenced-based cancer control approaches and planning at the local, regional and national levels.

Research programme for the 660 MeV proton accelerator driven MOX-plutonium subcritical assembly

International Nuclear Information System (INIS)

Barashenkov, V.S.; Buttsev, V.S.; Buttseva, G.L.; Dudarev, S.Yu.; Polanski, A.; Puzynin, I.V.; Sissakyan, A.N.

2000-01-01

The paper presents a research programme of the Experimental Accelerator Driven System (ADS), which employs a subcritical assembly and a 660 MeV proton accelerator operating at the Laboratory of Nuclear Problems of the JINR, Dubna. MOX fuel (25% PuO 2 + 75% UO 2 ) designed for the BN-600 reactor use will be adopted for the core of the assembly. The present conceptual design of the experimental subcritical assembly is based on a core of a nominal unit capacity of 15 kW (thermal). This corresponds to the multiplication coefficient k eff = 0.945, energetic gain G=30 and the accelerator beam power 0.5 kW

Present status of tandem accelerator research facility (MALT) in University of Tokyo

Energy Technology Data Exchange (ETDEWEB)

Kobayashi, Koichi; Hatori, Satoshi; Nakano, Chuichiro; Sunohara, Yoko [Tokyo Univ. (Japan). Research Center for Nuclear Science and Technology

1996-12-01

The tandem accelerator in University of Tokyo, which was renewed from 1991 to March, 1994 started the joint utilization within the University since April, 1995 after about one year of the period of adjustment. The time of operation exceeding 3500 hours in one year was recorded. This facility is that for carrying out the minute analysis such as AMS, PIXE, NRA and others and the research of atomic and molecular physics, and called microanalysis laboratory-tandem accelerator (MALT). Support has been done by placing emphasis on the development of AMS measurement which enables the microanalysis of {sup 14}C,{sup 10}Be and {sup 26}Al, but the accuracy of {sup 14}C AMS did not attain the practical level. {sup 10}Be and {sup 26}Al AMS reached almost the practical level, and the measurement of actual samples has been carried out. The state of operation and utilization of the MALT is reported. As to the recent troubles and the countermeasures in the MALT, the voltage instability of the accelerator, the unstable ion source support mechanism and the poor transmissivity of beam in the accelerator are described. (K.I.)

A survey of etiologic hypotheses among testicular cancer researchers

DEFF Research Database (Denmark)

Stang, A; Trabert, B; Rusner, C

2015-01-01

Basic research results can provide new ideas and hypotheses to be examined in epidemiological studies. We conducted a survey among testicular cancer researchers on hypotheses concerning the etiology of this malignancy. All researchers on the mailing list of Copenhagen Testis Cancer Workshops...... and corresponding authors of PubMed-indexed articles identified by the search term 'testicular cancer' and published within 10 years (in total 2750 recipients) were invited to respond to an e-mail-based survey. Participants of the 8th Copenhagen Testis Cancer Workshop in May 2014 were subsequently asked to rate...... that scored as most plausible. We also present plans for improving the survey that may be repeated at a next international meeting of experts in testicular cancer. Overall 52 of 99 (53%) registered participants of the 8th Copenhagen Testis Cancer Workshop submitted the plausibility rating form. Fourteen of 27...

Original Research Cervical cancer in southern Malawi: A ...

African Journals Online (AJOL)

by the fact that many cancers may go unrecorded and that ... International Agency for Research on Cancer's (IARC) ... All patients with a new diagnosis of cervical cancer presenting to QECH between ..... A specialist cervical cancer nurse could be appointed to ... Zuma, T., et al., The role of traditional health practitioners in.

Advancing Prostate Cancer Research by Providing Summer Research Opportunities for HBCU Students at the Cancer Center at UTHSCSA

Science.gov (United States)

2017-08-01

encouraging the students to attend the American Association for Cancer Research (AACR) meeting in Chicago in April 2018. The abstracts for this...Updates: Elucidating the Effects of Obesity on Bladder Cancer Progression - completed CTRC at UTHSCSA: Genomics Shared Resource; reduced from

Acceleration of 14C beams in electrostatic accelerators

International Nuclear Information System (INIS)

Rowton, L.J.; Tesmer, J.R.

1981-01-01

Operational problems in the production and acceleration of 14 C beams for nuclear structure research in Los Alamos National Laboratory's Van de Graaff accelerators are discussed. Methods for the control of contamination in ion sources, accelerators and personnel are described. Sputter source target fabrication techniques and the relative beam production efficiencies of various types of bound particulate carbon sputter source targets are presented

Accelerator research studies. Final report, June 1, 1991 - May 31, 1994

International Nuclear Information System (INIS)

1994-01-01

The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy is currently in the third year of its three-year funding cycle. The program consists of the following three tasks: Task A -- Study of the transport and longitudinal compression of intense, high-brightness beams; Task B -- Study of high-brightness beam generation in pseudospark devices; Task C -- Study of a gyroklystron high-power microwave source for linear colliders. The research for each task is detailed in this report

NIH Research Leads to Cervical Cancer Vaccine

Science.gov (United States)

... Issues Sexually Transmitted Diseases NIH Research Leads to Cervical Cancer Vaccine Past Issues / Fall 2008 Table of Contents ... in women, the cause of the majority of cervical cancers. Photo courtesy of Judy Folkenberg, NLM Writer By ...

Staff Clinician | Center for Cancer Research

Science.gov (United States)

The Neuro-Oncology Branch (NOB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) is seeking staff clinicians to provide high-quality patient care for individuals with primary central nervous system (CNS) malignancies.  The NOB is comprised of a multidisciplinary team of physicians, healthcare providers, and scientists who

Safety and adverse events of neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) for rectal cancer

International Nuclear Information System (INIS)

Doi, Hiroshi; Kamikonya, Norihiko; Hirota, Shozo; Beppu, Naohito; Yanagi, Hidenori

2014-01-01

We presented good tolerability and short-term outcomes of neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART; 25 Gy in 10 fractions for 5 days) combined with chemotherapy in a total of 73 patients with lower rectal cancer. Age, gender, tumor differentiation, and the type of surgery seemed to have no apparent effects on toxicity of SC-HART. SC-HART appeared to have a good feasibility for use in further clinical trials. (author)

Research Associate | Center for Cancer Research

Science.gov (United States)

The Basic Science Program (BSP) at the Frederick National Laboratory for Cancer Research (FNLCR) pursues independent, multidisciplinary research programs in basic or applied molecular biology, immunology, retrovirology, cancer biology or human genetics. As part of the BSP, the Microbiome and Genetics Core (the Core) characterizes microbiomes by next-generation sequencing to determine their composition and variation, as influenced by immune, genetic, and host health factors. The Core provides support across a spectrum of processes, from nucleic acid isolation through bioinformatics and statistical analysis. KEY ROLES/RESPONSIBILITIES The Research Associate II will provide support in the areas of automated isolation, preparation, PCR and sequencing of DNA on next generation platforms (Illumina MiSeq and NextSeq). An opportunity exists to join the Core’s team of highly trained experimentalists and bioinformaticians working to characterize microbiome samples. The following represent requirements of the position: A minimum of five (5) years related of biomedical experience. Experience with high-throughput nucleic acid (DNA/RNA) extraction. Experience in performing PCR amplification (including quantitative real-time PCR). Experience or familiarity with robotic liquid handling protocols (especially on the Eppendorf epMotion 5073 or 5075 platforms). Experience in operating and maintaining benchtop Illumina sequencers (MiSeq and NextSeq). Ability to evaluate experimental quality and to troubleshoot molecular biology protocols. Experience with sample tracking, inventory management and biobanking. Ability to operate and communicate effectively in a team-oriented work environment.

JAERI 20 MV tandem accelerator

International Nuclear Information System (INIS)

Tsukada, Kineo; Harada, Kichinosuke

1977-01-01

Accelerators have been developed as the experimental apparatuses for the studies on nuclei and elementary particles. One direction of the development is the acceleration of protons and electrons to more and more high energy, and another direction is the acceleration of heavy ions up to uranium to several MeV up to several hundreds MeV. However recently, accelerators are used as the useful tools for the studies in wider fields. There are electrostatic acceleration and high frequency acceleration in ion acceleration, and at present, super-large accelerators are high frequency acceleration type. In Japan Atomic Energy Research Institute, it was decided in 1975 to construct an electrostatic accelerator of tandem type in order to accelerate heavy ions. In case of the electrostatic acceleration, the construction is relatively simple, the acceleration of heavy ions is easy, the property of the ion beam is very good, and the energy is stable. Especially, the tandem type is convenient for obtaining high energy. The tandem accelerator of 20 MV terminal voltage was ordered from the National Electrostatics Corp., USA, and is expected to be completed in 1978. The significance of heavy ion acceleration in the development and research of atomic energy, tandem van de Graaff accelerators, the JAERI 20MV tandem accelerator, and the research project with this accelerator are described. (Kako, I.)

Eliminating cancer stem cells: an interview with CCR’s Steven Hou | Center for Cancer Research

Science.gov (United States)

Steven Hou, Ph.D., senior investigator in the Basic Research Laboratory at the Center for Cancer Research describes his latest research that has uncovered potential ways to eliminate cancer stem cells and may offer hope to patients with reoccurring tumors.  Learn more...

Applying the accelerator

Energy Technology Data Exchange (ETDEWEB)

Barbalat, Oscar

1989-12-15

Originally developed as tools for frontier physics, particle accelerators provide valuable spinoff benefits in applied research and technology. These accelerator applications are the subject of a biennial meeting in Denton, Texas, but the increasing activity in this field resulted this year (5-9 September) in the first European Conference on Accelerators in Applied Research and Technology, organized by K. Bethge of Frankfurt's Goethe University. The meeting reflected a wide range of applications - ion beam analysis, exploitation of nuclear microbeams, accelerator mass spectrometry, applications of photonuclear reactions, ion beam processing, synchrotron radiation for semiconductor technology, specialized technology.

Applying the accelerator

International Nuclear Information System (INIS)

Barbalat, Oscar

1989-01-01

Originally developed as tools for frontier physics, particle accelerators provide valuable spinoff benefits in applied research and technology. These accelerator applications are the subject of a biennial meeting in Denton, Texas, but the increasing activity in this field resulted this year (5-9 September) in the first European Conference on Accelerators in Applied Research and Technology, organized by K. Bethge of Frankfurt's Goethe University. The meeting reflected a wide range of applications - ion beam analysis, exploitation of nuclear microbeams, accelerator mass spectrometry, applications of photonuclear reactions, ion beam processing, synchrotron radiation for semiconductor technology, specialized technology

Accelerators for energy

International Nuclear Information System (INIS)

Inoue, Makoto

2000-01-01

A particle accelerator is a device to consume energy but not to produce it. Then, the titled accelerator seems to mean an accelerator for using devices related to nuclear energy. For an accelerator combined to nuclear fissionable fuel, neutron sources are D-T type, (gamma, n) reaction using electron beam type spallation type, and so forth. At viewpoints of powers of incident beam and formed neutron, a spallation type source using high energy proton is told to be effective but others have some advantages by investigation on easy operability, easy construction, combustion with target, energy and directivity of neutron, and so forth. Here were discussed on an accelerator for research on accelerator driven energy system by dividing its researching steps, and on kind, energy, beam intensity, and so forth of an accelerator suitable for it. And, space electric charge effect at beam propagation direction controlled by beam intensity of cyclotron was also commented. (G.K.)

Institutional shared resources and translational cancer research

Directory of Open Access Journals (Sweden)

De Paoli Paolo

2009-06-01

Full Text Available Abstract The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology. In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization

Institutional shared resources and translational cancer research.

Science.gov (United States)

De Paoli, Paolo

2009-06-29

The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology.In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization supporting clinical trial recruitment

Present state of works on development of electron accelerators for energy consuming processes at Efremov Research Institute

Energy Technology Data Exchange (ETDEWEB)

Ivanov, A. S.; Maznev, V. P.; Ovchinnikov, V. P.; Svinin, M. P.; Tolstun, N. G. [Efremov Research Institute of Electrophysical Apparatus, Saint-Petersburg (Russian Federation)

2011-07-01

Necessity to decrease anthropogenic environmental pollution puts a task of development of HV accelerators for introduction of nature conservation technologies in commercial scale. High efficiency and operation reliability in a power range noticeably higher than already mastered level are required. In design of the accelerators basic units, namely, HV generators, accelerating structures, electron beam irradiation field forming systems and extraction devices solutions that demonstrated already theirs operational capacity in the machines of a lesser power may be used. From the other hand, experience gained by already full-scale built powerful installations shows that a number of problems remain unsolved that put obstacles on a way of wide implementation of exhaust gases irradiation processing. Attempts to built the accelerator meeting all requirements in a frame of specific contracts, although already shown noticeable progress in a sense of the power grow, acquiring of very valuable experience, carry some risk caused by insufficient study of the problems connected with power increasing, lack of time and means for the thorough research works. It looks reasonable to suggest creation of full-scale pilot installation with HV accelerator of required power (1 MW, for example) not bound to a specific commercial contract, where researches and studies of the accelerator main systems, theirs optimization and longevity tests can be carried out thus providing development of the accelerator into really reliable and effective tool for applying to environmental tasks.

Measuring research impact: a large cancer research funding programme in Australia.

Science.gov (United States)

Bowden, Jacqueline A; Sargent, Nicole; Wesselingh, Steve; Size, Lincoln; Donovan, Claire; Miller, Caroline L

2018-05-09

Measuring research impact is of critical interest to philanthropic and government funding agencies interested in ensuring that the research they fund is both scientifically excellent and has meaningful impact into health and other outcomes. The Beat Cancer Project (BCP) is a AUD $34 m cancer research funding scheme that commenced in 2011. It was initiated by an Australian charity (Cancer Council SA), and supported by the South Australian Government and the state's major universities. This study applied Buxton and Hanney's Payback Framework to assess research impact generated from the BCP after 3 years of funding. Data sources were an audit of peer-reviewed publications from January 2011 to September 2014 from Web of Knowledge and a self-report survey of investigators awarded BCP research funding during its first 3 years of implementation (2011-2013). Of the 104 surveys, 92 (88%) were completed. The BCP performed well across all five categories of the Payback Framework. In terms of knowledge production, 1257 peer-reviewed publications were generated and the mean impact factor of publishing journals increased annually. There were many benefits to future research with 21 respondents (23%) reporting career advancement, and 110 higher degrees obtained or expected (including 84 PhDs). Overall, 52% of funded projects generated tools for future research. The funded research attracted substantial further income yielding a very high rate of leverage. For every AUD $1 that the cancer charity invested, the BCP gained an additional AUD $6.06. Five projects (5%) had informed policy and 5 (5%) informed product development, with an additional 31 (34%) and 35 (38%) projects, respectively, anticipating doing so. In terms of health and sector and broader economic benefits, 8 (9%) projects had influenced practice or behaviour of health staff and 32 (34%) would reportedly to do so in the future. Research impact was a priority of charity and government funders and led to a deliberate

Special issue - Applying the accelerator

International Nuclear Information System (INIS)

Anon.

1995-01-01

T'he CERN Courier is the international journal of high energy physics, covering current developments in and around this branch of basic science. A recurrent theme is applying the technology developed for particle accelerators, the machines which produce beams of high energy particles for physics experiments. Twentieth-century science is full of similar examples of applications derived from pure research. This special issue of the CERN Courier is given over to one theme - the applications of accelerators. Accelerator systems and facilities are normally associated with highenergy particle physics research, the search for fundamental particles and the quest to understand the physics of the Big Bang. To the layman, accelerator technology has become synonymous with large and expensive machines, exploiting the most modern technology for basic research. In reality, the range of accelerators and their applications is much broader. A vast number of accelerators, usually much smaller and operating for specific applications, create wealth and directly benefit the population, particularly in the important areas of healthcare, energy and the environment. There are well established applications in diagnostic and therapeutic medicine for research and routine clinical treatments. Accelerators and associated technologies are widely employed by industry for manufacturing and process control. In fundamental and applied research, accelerator systems are frequently used as tools. The biennial conference on the Applications of Accelerators in Industry and Research at Denton, Texas, attracts a thousand participants. This special issue of the CERN Courier includes articles on major applications, reflecting the diversity and value of accelerator technology. Under Guest Editor Dewi Lewis of Amersham International, contributions from leading international specialists with experience of the application end of the accelerator chain describe their fields of direct interest. The

Special issue - Applying the accelerator

Energy Technology Data Exchange (ETDEWEB)

Anon.

1995-07-15

T'he CERN Courier is the international journal of high energy physics, covering current developments in and around this branch of basic science. A recurrent theme is applying the technology developed for particle accelerators, the machines which produce beams of high energy particles for physics experiments. Twentieth-century science is full of similar examples of applications derived from pure research. This special issue of the CERN Courier is given over to one theme - the applications of accelerators. Accelerator systems and facilities are normally associated with highenergy particle physics research, the search for fundamental particles and the quest to understand the physics of the Big Bang. To the layman, accelerator technology has become synonymous with large and expensive machines, exploiting the most modern technology for basic research. In reality, the range of accelerators and their applications is much broader. A vast number of accelerators, usually much smaller and operating for specific applications, create wealth and directly benefit the population, particularly in the important areas of healthcare, energy and the environment. There are well established applications in diagnostic and therapeutic medicine for research and routine clinical treatments. Accelerators and associated technologies are widely employed by industry for manufacturing and process control. In fundamental and applied research, accelerator systems are frequently used as tools. The biennial conference on the Applications of Accelerators in Industry and Research at Denton, Texas, attracts a thousand participants. This special issue of the CERN Courier includes articles on major applications, reflecting the diversity and value of accelerator technology. Under Guest Editor Dewi Lewis of Amersham International, contributions from leading international specialists with experience of the application end of the accelerator chain describe their fields of direct interest. The contributions

Adherence to the cancer prevention recommendations of the World Cancer Research Fund/American Institute for Cancer Research and mortality: a census-linked cohort.

Science.gov (United States)

Lohse, Tina; Faeh, David; Bopp, Matthias; Rohrmann, Sabine

2016-09-01

Modifiable lifestyle factors linked to cancer offer great potential for prevention. Previous studies suggest an association between adherence to recommendations on healthy lifestyle and cancer mortality. The aim of this study was to examine whether adherence to the cancer prevention recommendations of the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) is associated with reduced all-cause, total cancer, and specific cancer type mortality. We built a lifestyle score that included 3 categories, based on the recommendations of the WCRF/AICR. Applying Cox regression models, we investigated the association with all-cause, total cancer, and specific cancer type mortality; in addition, we included cardiovascular disease (CVD) mortality. We used census- and death registry-linked survey data allowing a mortality follow-up for ≤32 y. Our analysis included 16,722 participants. Information on lifestyle score components and confounders was collected at baseline. Over a mean follow-up of 21.7 y, 3730 deaths were observed (1332 cancer deaths). Comparing best with poorest category of the lifestyle score showed an inverse association with all-cause (HR: 0.82; 95% CI: 0.75, 0.89) and total cancer (men only, HR: 0.69; 95% CI: 0.57, 0.84) mortality. We estimated that ∼13% of premature cancer deaths in men would have been preventable if lifestyle score levels had been high. Inverse associations were observed for lung, upper aerodigestive tract, stomach, and prostate cancer mortality [men and women combined, HR: 0.72; 95% CI: 0.51, 0.99; HR: 0.49; 95% CI: 0.26, 0.92; HR: 0.34; 95% CI: 0.14, 0.83; HR: 0.48; 95% CI: 0.28, 0.82 (men only), respectively]. CVD mortality was not associated with the lifestyle score (men and women combined, HR: 0.96; 95% CI: 0.82, 1.13). Our results support the importance of adhering to recommendations for a healthy lifestyle with regard to all-cause and cancer mortality. To reduce the burden of cancer in the

A Seat at the Table: Culturally based cancer research

Science.gov (United States)

NCI supports research to address cancer disparities among American Indian and Alaska Native populations. In this video, two researchers advocate for more culturally sensitive practices to help people who are most disproportionately affected by cancer disparities.

Development of breast cancer irradiation technique for BNCT at JRR-4

International Nuclear Information System (INIS)

Nakamura, Takemi; Horiguchi, Hironori; Arai, Masaji; Yanagie, Hironobu

2014-06-01

In the Department of Research Reactor and Tandem Accelerator, developments of irradiation technique with application enlargement for breast cancer on BNCT have been performed in the second medium term plans. We compiled this report about the technological development to solve several problems with the irradiation of breast cancer in the medical irradiation facility of JRR-4. In the present study, design fabrication of a collimator for breast cancer, dose evaluation analysis by clinical model, investigation of dose enhancement at deeper region and investigation of fixing method for breast cancer irradiation were studied. By these evaluation results, we verified that the developed breast cancer irradiation technique can be applied to BNCT medical irradiation of JRR-4. These results are expected to be able to contribute to breast cancer irradiation techniques of other reactor-based BNCT and future accelerator-based BNCT. (author)

Applications of particle accelerators

International Nuclear Information System (INIS)

Barbalat, O.

1994-01-01

Particle accelerators are now widely used in a variety of applications for scientific research, applied physics, medicine, industrial processing, while possible utilisation in power engineering is envisaged. Earlier presentations of this subject, given at previous CERN Accelerator School sessions have been updated with papers contributed to the first European Conference on Accelerators in Applied Research and Technology (ECAART) held in September 1989 in Frankfurt and to the Second European Particle Accelerator Conference in Nice in June 1990. (orig.)

Stakeholder engagement for comparative effectiveness research in cancer care: experience of the DEcIDE Cancer Consortium.

Science.gov (United States)

Greenberg, Caprice C; Wind, Jennifer K; Chang, George J; Chen, Ronald C; Schrag, Deborah

2013-03-01

Stakeholder input is a critical component of comparative effectiveness research. To ensure that the research activities of the Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Network, supported by the Agency for Healthcare Research and Quality, translate into the greatest impact for everyday practice and policy-making in cancer, we were tasked with soliciting stakeholder input regarding priority areas in cancer-related comparative effectiveness research for the DEcIDE Cancer Consortium. Given the increasing emphasis on stakeholder engagement in research, many investigators are facing a similar task, yet there is limited literature to guide such efforts, particularly in cancer care. To help fill this gap, we present our approach to operationalizing stakeholder engagement and discuss it in the context of other recent developments in the area. We describe challenges encountered in convening stakeholders from multiple vantage points to prioritize topics and strategies used to mitigate these barriers. We offer several recommendations regarding how to best solicit stakeholder input to inform comparative effectiveness research in cancer care. These recommendations can inform other initiatives currently facing the challenges of engaging stakeholders in priority setting for cancer.

Senior Laboratory Animal Technician | Center for Cancer Research

Science.gov (United States)

PROGRAM DESCRIPTION The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused

Kids, Adolescents, and Young Adults Cancer Study-A Methodological Approach in Cancer Epidemiology Research

International Nuclear Information System (INIS)

Link, N. L.; Maurer, E.; Largent, J.; Kent, E.; Sender, E.; Culver, H. A.; Morris, R. A.; Sender, E.

2009-01-01

Advances have been made in treatment and outcomes for pediatric cancer. However adolescents and young adults (AYAs) with cancer have not experienced similar relative improvements. We undertook a study to develop the methodology necessary for epidemiologic cancer research in these age groups. Our goal was to create the Kids, Adolescents, and Young Adults Cancer (KAYAC) project to create a resource to address research questions relevant to this population. We used a combination of clinic and population-based ascertainment to enroll 111 cases aged 0-39 for this methodology development study. The largest groups of cancer types enrolled include: breast cancer, leukemia, lymphoma, and melanoma. The overall participation rate is 69.8% and varies by age and tumor type. The study included patients, mothers, and fathers. The methods used to establish this resource are described, and the values of the resource in studies of childhood and young adult cancer are outlined.

[Tissue repositories for research at Sheba Medical Center(SMC].

Science.gov (United States)

Cohen, Yehudit; Barshack, Iris; Onn, Amir

2013-06-01

Cancer is the number one cause of death in both genders. Breakthroughs in the understanding of cancer biology, the identification of prognostic factors, and the development of new treatments are increasingly dependent on access to human cancer tissues with linked clinicopathological data. Access to human tumor samples and a large investment in translational research are needed to advance this research. The SMC tissue repositories provide researchers with biological materials, which are essential tools for cancer research. SMC tissue repositories for research aim to collect, document and preserve human biospecimens from patients with cancerous diseases. This is in order to provide the highest quality and well annotated biological biospecimens, used as essential tools to achieve the growing demands of scientific research needs. Such repositories are partners in acceLerating biomedical research and medical product development through clinical resources, in order to apply best options to the patients. Following Institutional Review Board approval and signing an Informed Consent Form, the tumor and tumor-free specimens are coLLected by a designated pathologist at the operating room only when there is a sufficient amount of the tumor, in excess of the routine needs. Blood samples are collected prior to the procedure. Other types of specimens collected include ascites fluid, pleural effusion, tissues for Optimal Cutting Temperature [OCT] and primary culture etc. Demographic, clinical, pathologicaL, and follow-up data are collected in a designated database. SMC has already established several organ or disease-specific tissue repositories within different departments. The foundation of tissue repositories requires the concentrated effort of a multidisciplinary team composed of paramedical, medical and scientific professionals. Research projects using these specimens facilitate the development of 'targeted therapy', accelerate basic research aimed at clarifying molecular

Development of small applied accelerator in Tokyo Institute of Technology

CERN Document Server

Hattori, T

2002-01-01

Interdigital-H(IH) Linac was constructed and applied to materials research in the University. IH Linac uses 1.6 MV small tandem pelletron and accelerates ion (>Q/A=1/4) from 240 KeV to 2.4 MeV. The secondary IH Linac was built and increased the energy to 3.4 MeV/u. In order to apply linac to therapy, IH Linac for PET (Position Emission Tomography), Carbon 6 MeV/u Linac for cancer therapy, APF (Alternating Phase Focus)-IH prototype linac, Carbon 2 MeV/u test APF-IH linac were developed. On application to semiconductor and industry, IHQ type MeV ion implantation device, APF-IH type MeV ion implantation device and high-energy electron accelerator were developed. A bone density measurement instrument was developed and the data was proved better values than ordinary instrument. The problems of prototype small accelerator are summarized. (S.Y.)

Antibody Characterization Lab | Office of Cancer Clinical Proteomics Research

Science.gov (United States)

The Antibody Characterization Lab (ACL), an intramural reference laboratory located at the Frederick National Laboratory for Cancer Research in Frederick, Maryland, thoroughly characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research.

Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

Science.gov (United States)

Yogo, A.; Sato, K.; Nishikino, M.; Mori, M.; Teshima, T.; Numasaki, H.; Murakami, M.; Demizu, Y.; Akagi, S.; Nagayama, S.; Ogura, K.; Sagisaka, A.; Orimo, S.; Nishiuchi, M.; Pirozhkov, A. S.; Ikegami, M.; Tampo, M.; Sakaki, H.; Suzuki, M.; Daito, I.; Oishi, Y.; Sugiyama, H.; Kiriyama, H.; Okada, H.; Kanazawa, S.; Kondo, S.; Shimomura, T.; Nakai, Y.; Tanoue, M.; Sasao, H.; Wakai, D.; Bolton, P. R.; Daido, H.

2009-05-01

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8-2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

Annual report of Department of Research Reactor and Tandem Accelerator, JFY2014. Operation, Utilization and Technical Development of JRR-3, JRR-4, NSRR, Tandem Accelerator and RI Production Facility

International Nuclear Information System (INIS)

Osa, Akihiko; Imahashi, Masaki; Hirane, Nobuhiko; Motome, Yuiko; Tayama, Hidekazu; Tamura, Itaru; Harada, Yuko; Sakata, Mami; Kadokura, Masakazu; Takita, Chiharu

2017-02-01

The Department of Research Reactor and Tandem Accelerator is in charge of the operation, utilization and technical development of JRR-3 (Japan Research Reactor No.3), JRR-4 (Japan Research Reactor No.4), NSRR (Nuclear Safety Research Reactor), Tandem Accelerator and RI Production Facility. This annual report describes the activities of our department in fiscal year of 2014. We carried out the operation and maintenance, utilization, upgrading of utilization techniques, safety administration, and international cooperation. Also contained are lists of publications, meetings, granted permissions on laws and regulations concerning atomic energy, outcomes in service and technical developments and so on. (author)

Annual report of Department of Research Reactor and Tandem Accelerator, JFY2013. Operation, Utilization and Technical Development of JRR-3, JRR-4, NSRR, Tandem Accelerator and RI Production Facility

International Nuclear Information System (INIS)

Kashima, Yoichi; Murayama, Yoji; Nakamura, Kiyoshi; Uno, Yuki; Hirane, Nobuhiko; Ohuchi, Hitoshi; Ishizaki, Nobuhiro; Matsumura, Taichi; Nagahori, Kazuhisa; Harada, Yuko; Kadokura, Masakazu; Machi, Sumire; Takita, Chiharu

2015-02-01

The Department of Research Reactor and Tandem Accelerator is in charge of the operation, utilization and technical development of JRR-3(Japan Research Reactor No.3), JRR-4(Japan Research Reactor No.4), NSRR(Nuclear Safety Research Reactor), Tandem Accelerator and RI Production Facility. This annual report describes the activities of our department in fiscal year of 2013. We carried out the operation and maintenance, utilization, upgrading of utilization techniques, safety administration and international cooperation. Also contained are lists of publications, meetings, granted permissions on laws and regulations concerning atomic energy, outcomes in service and technical developments and so on. (author)

Postdoctoral Fellow | Center for Cancer Research

Science.gov (United States)

Dr. St. Croix’s laboratory at the Mouse Cancer Genetics Program (MCGP), National Cancer Institute, USA has an open postdoctoral position. We seek a highly motivated, creative and bright individual to participate in a collaborative project that involves the targeting of tumor-associated stroma using T-cells engineered to express chimeric antigen receptors (CARs). The laboratory focuses on the characterization and exploitation of molecules associated with tumor angiogenesis. The successful candidate would be involved in developing, producing and characterizing new therapeutic antibodies and CARs that recognize cancer cells or its associated stroma, and preclinical testing of these agents using mouse tumor models. The tumor angiogenesis lab is located at the National Cancer Institute in Frederick with access to state-of-the-art facilities for antibody engineering, genomic analysis, pathology, and small animal imaging, among others. Detailed information about Dr. St. Croix’s research and publications can be accessed at https://ccr.cancer.gov/Mouse-Cancer-Genetics-Program/brad-st-croix.

Staff Scientist - RNA Bioinformatics | Center for Cancer Research

Science.gov (United States)

The newly established RNA Biology Laboratory (RBL) at the Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) in Frederick, Maryland is recruiting a Staff Scientist with strong expertise in RNA bioinformatics to join the Intramural Research Program’s mission of high impact, high reward science. The RBL is the equivalent of an

Priority research areas to accelerate the development of practical ultraconductive copper conductors

Energy Technology Data Exchange (ETDEWEB)

Lee, Dominic F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burwell, Malcolm [International Copper Association, Washington, DC (United States); Stillman, H. [International Copper Association, Washington, DC (United States)

2015-09-01

This report documents the findings at an Ultraconductive Copper Strategy Meeting held on March 11, 2015 in Washington DC. The aim of this meeting was to bring together researchers of ultraconductive copper in the U.S. to identify and prioritize critical non-proprietary research activities that will enhance the understanding in the material and accelerate its development into practical conductors. Every effort has been made to ensure that the discussion and findings are accurately reported in this document.

Accelerator research studies: Technical progress report, June 1, 1988--May 31, 1989

International Nuclear Information System (INIS)

1989-01-01

This report discusses research progress in the following general topics: Study of transport and longitudinal compression of intense, high-brightness beams; study of collective ion acceleration by intense electron beams and pulse powered plasma focus; and study of microwave sources and parameter scaling for high-frequency electron-positron supercollider linacs

A Review of Lung Cancer Research in Malaysia.

Science.gov (United States)

Kan, C S; Chan, K M J

2016-06-01

Lung cancer is a major cause of mortality and morbidity in Malaysia and worldwide. This paper reviews all research and publications on lung cancer in Malaysia published between 2000-2015. 89 papers were identified, of which 64 papers were selected and reviewed on the basis of their relevance to the review. The epidemiology, risk factors, cell types, clinical presentation, diagnosis, treatment, outcomes, prevention, and the social impact of lung cancer in the country are reviewed and summarized. The clinical relevance of the studies done in the country are discussed along with recommendations for future research.

MATWIN: bridging the gap between academic research and industry.

Science.gov (United States)

Reiffers, Josy; Robert, Lucia

2015-09-16

MATWIN (Maturation and Accelerating Translation With INdustry) is part of the nationwide effort to support cancer innovation. This unique program is willing to support innovative research projects providing tools, resources, and staff dedicated to project leaders wishing to optimize the industrial attractiveness of their project. The overall objective is clear: fight cancer always more effectively.

Prostate Cancer Research Trial Helps John Spencer Treat His Cancer | NIH MedlinePlus the Magazine

Science.gov (United States)

... of this page please turn Javascript on. Feature: Prostate Cancer Prostate Cancer Research Trial Helps John Spencer Treat His Cancer ... because of timely detection and treatment of his prostate cancer. He participated in an NIH-sponsored clinical trial. ...

A Cross-Cultural Perspective on Challenges Facing Comparative Cancer Survivorship Research

International Nuclear Information System (INIS)

Syse, A.; Syse, A.; Geller, B.

2011-01-01

Cancer survivorship research includes the study of physical, psychosocial, and economic consequences of cancer diagnosis and treatment among pediatric and adult cancer survivors. Historically, the majority of cancer survivorship studies were from the United States, but survivorship issues are increasingly being addressed in other developed countries. Cross-cultural studies remain, however, scarce. The degree to which knowledge attained may or may not be transferred across cultures, countries, or regions is not known. Some important challenges for comparative research are therefore discussed in a cross-cultural perspective. Several substantive and methodological challenges that complicate the execution of cross-cultural cancer survivorship research are presented with examples and discussed to facilitate comparative research efforts in the establishment of new survivorship cohorts and in the planning and implementation of survivorship studies. Comparative research is one key to understanding the nature of cancer survivorship, distinguishing modifiable from non modifiable factors at individual, hospital, societal, and system levels and may thus guide appropriate interventions. Lastly, suggested future courses of action within the field of comparative cancer survivorship research are provided.

Recent progress in particle accelerators

International Nuclear Information System (INIS)

Cole, F.T.; Mills, F.E.

1988-01-01

Many accelerators have also been built for medical radiography and therapy. Electron accelerators for this application are available commercially, using the electrons directly or bremsstrahlung photons. Neutrons produced by accelerator beams have also been used for therapy with considerable success, and several proton accelerators built for physics research have been adapted for direct therapy with protons. The first proton accelerator specifically for therapy is now being built. Separate from what might be called conventional accelerator technology, an entirely new field utilizing very highly pulsed power has been developed, and beams of short pulses of thousands or millions of amperes peak current in the MeV energy range are now available. These beams have important applications in high-energy particle acceleration, controlled fusion, industrial treatment of materials, and possibly in food preservation. All of these accelerators make use of external fields of acceleration. There is also vigorous research into new methods of acceleration, in many schemes making use of the intense accelerating fields, generated by laser beams or by plasma states of matter. This research has not as yet made traditional kinds of accelerators outmoded, but many workers hope that early in the next century there will be practical new acceleration methods making use of these very high fields. These developments are discussed in detail

Need for global partnership in cancer care: perceptions of cancer care researchers attending the 2010 australia and Asia pacific clinical oncology research development workshop.

Science.gov (United States)

Lyerly, H Kim; Abernethy, Amy P; Stockler, Martin R; Koczwara, Bogda; Aziz, Zeba; Nair, Reena; Seymour, Lesley

2011-09-01

To understand the diversity of issues and the breadth of growing clinical care, professional education, and clinical research needs of developing countries, not typically represented in Western or European surveys of cancer care and research. A cross-sectional survey was conducted of the attendees at the 2010 Australia and Asia Pacific Clinical Oncology Research Development workshop (Queensland, Australia) about the most important health care questions facing the participant's home countries, especially concerning cancer. Early-career oncologists and advanced oncology trainees from a region of the world containing significant low- and middle-income countries reported that cancer is an emerging health priority as a result of aging of the population, the impact of diet and lifestyle, and environmental pollution. There was concern about the capacity of health care workers and treatment facilities to provide cancer care and access to the latest cancer therapies and technologies. Although improving health care delivery was seen as a critical local agenda priority, focusing on improved cancer research activities in this select population was seen as the best way that others outside the country could improve outcomes for all. The burden of cancer will increase dramatically over the next 20 years, particularly in countries with developing and middle-income economies. Cancer research globally faces significant barriers, many of which are magnified in the developing country setting. Overcoming these barriers will require partnerships sensitive and responsive to both local and global needs.

Summer Student Breast Cancer Research Training Program

Science.gov (United States)

2006-05-01

kinase inhibition on ERK activity in breast cancer cells, the role of the calpain proteolytic pathway in breast cancer-induced cachexia , and the...research training; breast cancer; fatty acids and prevention; nutrition and prevention; alternative prevention 16. SECURITY CLASSIFICATION OF...growth. In in vivo experiments, mice were fed diets that were rich in either omega-3 (fish oil) or omega-6 (corn oil) fatty acids. Three weeks after

The UK-SEA-ME Psychosocial-Cultural Cancer Research Network: setting the stage for applied qualitative research on cancer health behaviour in southeast Asia and the Middle East.

Science.gov (United States)

Lim, Jennifer N W

2011-01-01

Psychosocial and cultural factors influencing cancer health behaviour have not been systematically investigated outside the western culture, and qualitative research is the best approach for this type of social research. The research methods employed to study health problems in Asia predominantly are quantitative techniques. The set up of the first psychosocial cancer research network in Asia marks the beginning of a collaboration to promote and spearhead applied qualitative healthcare research in cancer in the UK, Southeast Asia and the Middle East. This paper sets out the rationale, objectives and mission for the UK-SEA-ME Psychosocial-Cultural Cancer Research Network. The UK-SEA-ME network is made up of collaborators from the University of Leeds (UK), the University of Malaya (Malaysia), the National University of Singapore (Singapore) and the University of United Arab Emirates (UAE). The network promotes applied qualitative research to investigate the psychosocial and cultural factors influencing delayed and late presentation and diagnosis for cancer (breast cancer) in partner countries, as well as advocating the use of the mixed-methods research approach. The network also offers knowledge transfer for capacity building within network universities. The mission of the network is to improve public awareness about the importance of early management and prevention of cancer through research in Asia.

PVAMU/XULA/BCM Summer Prostate Cancer Research Program

Science.gov (United States)

2017-10-01

degradation of several cancer -related proteins, including the androgen receptor , which is dysregulated in certain prostate cancers . Overall, the goal of my...Behavior of Androgen Receptor Splice Variants in Androgen Dependent Prostate Cancer Cells Turner, Williamson D., Xavier University of Louisiana, Class...AWARD NUMBER: W81XWH-15-1-0677 TITLE: PVAMU/XULA/BCM Summer Prostate Cancer Research Program PRINCIPAL INVESTIGATOR: Nancy L. Weigel

Nuclear safeguards research with the LASL 3. 75-MV Van de Graaff accelerator

Energy Technology Data Exchange (ETDEWEB)

Krick, M.S.; Evans, A.E.

1976-01-01

The continued use of the Los Alamos Scientific Laboratory (LASL) 3.75-MV Van de Graaff accelerator for the nondestructive assay of nuclear material in support of nuclear safeguards is reviewed. A brief description of the accelerator facility and the small-sample assay station (SSAS) is provided. Factors affecting high-accuracy assay of small samples are outlined. Examples are provided for the assay of uranium--thorium mixtures, low-level uranium samples, and high-temperature gas-cooled reactor (HTGR) fuel rods. Research on delayed-neutron energy spectra, radiation damage to /sup 3/He proportional counters, and /sup 4/He gas scintillators is summarized.

US-LA CRN Clinical Cancer Research in Latin America

Science.gov (United States)

The United States – Latin America Cancer Research Network (US-LA CRN) convened its Annual Meeting, in coordination with the Ministry of Health of Chile to discuss the Network’s first multilateral clinical research study: Molecular Profiling of Breast Cancer (MPBC).

Lower Breast Cancer Risk among Women following the World Cancer Research Fund and American Institute for Cancer Research Lifestyle Recommendations: EpiGEICAM Case-Control Study.

Directory of Open Access Journals (Sweden)

Adela Castelló

Full Text Available According to the "World Cancer Research Fund" and the "American Institute of Cancer Research" (WCRF/AICR one in four cancer cases could be prevented through a healthy diet, weight control and physical activity.To explore the association between the WCRF/AICR recommendations and risk of breast cancer.During the period 2006 to 2011 we recruited 973 incident cases of breast cancer and 973 controls from 17 Spanish Regions. We constructed a score based on 9 of the WCRF/AICR recommendations for cancer prevention:: 1Maintain adequate body weight; 2Be physically active; 3Limit the intake of high density foods; 4Eat mostly plant foods; 5Limit the intake of animal foods; 6Limit alcohol intake; 7Limit salt and salt preserved food intake; 8Meet nutritional needs through diet; S1Breastfeed infants exclusively up to 6 months. We explored its association with BC by menopausal status and by intrinsic tumor subtypes (ER+/PR+ & HER2-; HER2+; ER&PR-&HER2- using conditional and multinomial logistic models respectively.Our results point to a linear association between the degree of noncompliance and breast cancer risk. Taking women who met 6 or more recommendations as reference, those meeting less than 3 showed a three-fold excess risk (OR=2.98(CI95%:1.59-5.59, especially for postmenopausal women (OR=3.60(CI95%:1.24;10.47 and ER+/PR+&HER2- (OR=3.60(CI95%:1.84;7.05 and HER2+ (OR=4.23(CI95%:1.66;10.78 tumors. Noncompliance of recommendations regarding the consumption of foods and drinks that promote weight gain in premenopausal women (OR=2.24(CI95%:1.18;4.28; p for interaction=0.014 and triple negative tumors (OR=2.93(CI95%:1.12-7.63; the intake of plant foods in postmenopausal women (OR=2.35(CI95%:1.24;4.44 and triple negative tumors (OR=3.48(CI95%:1.46-8.31; and the alcohol consumption in ER+/PR+&HER2- tumors (OR=1.52 (CI95%:1.06-2.19 showed the strongest associations.Breast cancer prevention might be possible by following the "World Cancer Research Fund" and the

Development and application of compact and on-chip electron linear accelerators for dynamic tracking cancer therapy and DNA damage/repair analysis

Science.gov (United States)

Uesaka, M.; Demachi, K.; Fujiwara, T.; Dobashi, K.; Fujisawa, H.; Chhatkuli, R. B.; Tsuda, A.; Tanaka, S.; Matsumura, Y.; Otsuki, S.; Kusano, J.; Yamamoto, M.; Nakamura, N.; Tanabe, E.; Koyama, K.; Yoshida, M.; Fujimori, R.; Yasui, A.

2015-06-01

We are developing compact electron linear accelerators (hereafter linac) with high RF (Radio Frequency) frequency (9.3 GHz, wavelength 32.3 mm) of X-band and applying to medicine and non-destructive testing. Especially, potable 950 keV and 3.95 MeV linac X-ray sources have been developed for on-site transmission testing at several industrial plants and civil infrastructures including bridges. 6 MeV linac have been made for pinpoint X-ray dynamic tracking cancer therapy. The length of the accelerating tube is ∼600 mm. The electron beam size at the X-ray target is less than 1 mm and X-ray spot size at the cancer is less than 3 mm. Several hardware and software are under construction for dynamic tracking therapy for moving lung cancer. Moreover, as an ultimate compact linac, we are designing and manufacturing a laser dielectric linac of ∼1 MeV with Yr fiber laser (283 THz, wavelength 1.06 pm). Since the wavelength is 1.06 μm, the length of one accelerating strcture is tens pm and the electron beam size is in sub-micro meter. Since the sizes of cell and nuclear are about 10 and 1 μm, respectively, we plan to use this “On-chip” linac for radiation-induced DNA damage/repair analysis. We are thinking a system where DNA in a nucleus of cell is hit by ∼1 μm electron or X-ray beam and observe its repair by proteins and enzymes in live cells in-situ.

Accelerating cancer therapy development: the importance of combination strategies and collaboration. Summary of an Institute of Medicine workshop.

Science.gov (United States)

LoRusso, Patricia M; Canetta, Renzo; Wagner, John A; Balogh, Erin P; Nass, Sharyl J; Boerner, Scott A; Hohneker, John

2012-11-15

Cancer cells contain multiple genetic changes in cell signaling pathways that drive abnormal cell survival, proliferation, invasion, and metastasis. Unfortunately, patients treated with single agents inhibiting only one of these pathways--even if showing an initial response--often develop resistance with subsequent relapse or progression of their cancer, typically via the activation of an alternative uninhibited pathway. Combination therapies offer the potential for inhibiting multiple targets and pathways simultaneously to more effectively kill cancer cells and prevent or delay the emergence of drug resistance. However, there are many unique challenges to developing combination therapies, including devising and applying appropriate preclinical tests and clinical trial designs, prioritizing which combination therapies to test, avoiding overlapping toxicity of multiple agents, and overcoming legal, cultural, and regulatory barriers that impede collaboration among multiple companies, organizations, and/or institutions. More effective strategies to efficiently develop combination cancer therapies are urgently needed. Thus, the Institute of Medicine's National Cancer Policy Forum recently convened a workshop with the goal of identifying barriers that may be impeding the development of combination investigational cancer therapies, as well as potential solutions to overcome those barriers, improve collaboration, and ultimately accelerate the development of promising combinations of investigational cancer therapies. ©2012 AACR.

Proposed Special Issue: Progress of cancer research in developing countries

Directory of Open Access Journals (Sweden)

T.S. Jong

2016-10-01

Full Text Available As developing economies[1] around the world become more socially affluent in the coming decades, the incidence of cancer-related mortality is expected rise significantly owing to a combination of lifestyle changes and multiple environmental factors (Figure 1. Based on statistics from the World Health Organization, developing countries accounted for nearly 72% of cancer mortality in 2008 even though the average disease incidence in these countries is lower compared to that of high-income nations[3]It has been projected that up to 60% (ca. 15–20 million of new cancer cases will occur in developing countries by the year 2020[4-6], causing more deaths than AIDS, malaria, and tuberculosis combined. In the past, cancer management in developing countries has focused heavily on disease prevention, general awareness improvement, and early detection, while deprioritizing treatment and research efforts as a result of limited resources[7]. However, given the severity of the situation, it is now necessary to recalibrate our focus and reprioritize the investment of valuable resources in the fight against cancer.With respect to cancer research in developing countries, a major challenge faced by international researchers is the lack of reliable data[6], along with a limited research output from the developing world, which hampers our general understanding of the capability of these countries in dealing with the cancer pandemic. From 2011 to 2015, the average combined research output from developing countries constituted only 20% of the total publication output of the world’s top 100 most published countries in the field of oncology (Figure 2. Nonetheless, developing countries have recorded an impressive 20% average year-on-year increase in terms of their publication output during this period, and five of these countries contributed to more than three quarter of the total number of papers published (Figure 3.In contrast, developed nations only registered a 4

The Experimental Stand for Research of Wakefield Method of Charged Particles Acceleration

International Nuclear Information System (INIS)

Kiselev, V.A.; Linnik, A.F.; Onishchenko, I.N.; Onishchenko, N.I.; Sotnikov, G.V.; Uskov, V.V.

2006-01-01

The experimental installation and diagnostic equipment with motivation to use for various researches of wakefield method of charged particles acceleration both in plasma and in dielectric structure has been described. The main parameters of a sequence of short relativistic electron bunch and values of physical characteristics of slow-down structures have been presented

Development of electron linear accelerators in SAMEER

International Nuclear Information System (INIS)

Krishnan, R.

2015-01-01

LINear Accelerator (LINAC) based Radiotherapy machine is a key tool for Cancer Treatment. The number of such linac machines available is far less than the actual requirement projected, to suffice the needs of the vast number of Cancer Patients in the country. Development of indigenous state-of-art cancer therapy machine was therefore a crucial achievement under the Jai Vigyan Project of Govt. of India. With the support of Department of Electronics and Information Technology (DeitY), Govt of India, SAMEER has successfully developed 6 MV Radiation Oncology machine at par international standards and is being used to treat cancer patients in the country. SAMEER is also currently developing the dual photon energy and multiple electron energy medical linac machine for radiotherapy and also critical accessories to make a complete oncology system required for advanced state of art treatment. In this paper the work in SAMEER on electron linear accelerators for the medical applications and the related technology and facilities available will be presented. (author)

Multiple purpose research complex on the basis of electron accelerators and terahertz free electron laser

International Nuclear Information System (INIS)

Kulipanov, G.N.

2009-01-01

In this report the basic positioning parameters of multiple purpose research complex are presented, the list of potential experiments and technological uses on the example of results received in the multiuser center of G.I. Budker Institut of nuclear physics Siberian department of the Russian Academy of Sciences is discussed. This research complex is directed on work in the big universities and nano technology centers. Electron accelerators is intended for development of electron-beam technologies different material modification, for production of nano powder, nano materials and solution of ecological tasks. In this work the project of multiple purpose research complex on the basis of new generation electron accelerator Il-14 and workable terahertz free electron laser is suggested. Terahertz free electron laser will be used for researches in the sphere of physics and chemistry, biology and medicine, nanotechnology engineering and different methods of nanodiagnostics.

Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression.

Science.gov (United States)

Rao, Velidi H; Vogel, Kristen; Yanagida, Jodi K; Marwaha, Nitin; Kandel, Amrit; Trempus, Carol; Repertinger, Susan K; Hansen, Laura A

2015-10-01

Solar ultraviolet (UV) radiation can cause severe damage to the skin and is the primary cause of most skin cancer. UV radiation causes DNA damage leading to mutations and also activates the Erbb2/HER2 receptor through indirect mechanisms involving reactive oxygen species. We hypothesized that Erbb2 activation accelerates the malignant progression of UV-induced skin cancer. Following the induction of benign squamous papillomas by UV exposure of v-ras(Ha) transgenic Tg.AC mice, mice were treated topically with the Erbb2 inhibitor AG825 and tumor progression monitored. AG825 treatment reduced tumor volume, increased tumor regression, and delayed the development of malignant squamous cell carcinoma (SCC). Progression to malignancy was associated with increased Erbb2 and ADAM12 (A Disintegin And Metalloproteinase 12) transcripts and protein, while inhibition of Erbb2 blocked the increase in ADAM12 message upon malignant progression. Similarly, human SCC and SCC cell lines had increased ADAM12 protein and transcripts when compared to normal controls. To determine whether Erbb2 up-regulation of ADAM12 contributed to malignant progression of skin cancer, Erbb2 expression was modulated in cultured SCC cells using forced over-expression or siRNA targeting, demonstrating up-regulation of ADAM12 by Erbb2. Furthermore, ADAM12 transfection or siRNA targeting revealed that ADAM12 increased both the migration and invasion of cutaneous SCC cells. Collectively, these results suggest Erbb2 up-regulation of ADAM12 as a novel mechanism contributing to the malignant progression of UV-induced skin cancer. Inhibition of Erbb2/HER2 reduced tumor burden, increased tumor regression, and delayed the progression of benign skin tumors to malignant SCC in UV-exposed mice. Inhibition of Erbb2 suppressed the increase in metalloproteinase ADAM12 expression in skin tumors, which in turn increased migration and tumor cell invasiveness. © 2014 Wiley Periodicals, Inc.

Quality of life assessment in advanced non-small-cell lung cancer patients undergoing an accelerated radiotherapy regimen: report of ECOG study 4593

International Nuclear Information System (INIS)

Auchter, Richard M.; Scholtens, Denise; Adak, Sudeshna; Wagner, Henry; Cella, David F.; Mehta, Minesh P.

2001-01-01

Purpose: To prospectively evaluate the quality of life (QOL) before, at completion, and after therapy for patients receiving an accelerated fractionation schedule of radiotherapy for advanced, unresectable non-small-cell lung cancer in a Phase II multi-institutional trial. Methods and Materials: The Functional Assessment of Cancer Therapy-Lung (FACT-L) patient questionnaire was used to score the QOL in patients enrolled in the Eastern Cooperative Oncology Group Phase II trial (ECOG 4593) of hyperfractionated accelerated radiotherapy in non-small-cell lung cancer. Radiotherapy (total dose 57.6 Gy in 36 fractions) was delivered during 15 days, with three radiation fractions given each treatment day. The protocol was activated in 1993, and 30 patients had accrued by November 1995. The FACT-L questionnaire was administered at study entry (baseline), on the last day of radiotherapy (assessment 2), and 4 weeks after therapy (assessment 3). The FACT-L includes scores for physical, functional, emotional, and social well-being (33 items), and a subscale of lung cancer symptoms (10 additional items). The summation of the physical, functional, and lung cancer symptom subscales (21 items) constitutes the Trial Outcome Index (TOI), considered the most clinically relevant outcome measure in lung cancer treatment trials. Results: The FACT-L completion rates at the designated study time points were as follows: baseline, 30 of 30 (100%); assessment 2, 29 (97%) of 30; and assessment 3, 24 (80%) of 30. At treatment completion, statistically significant declines in QOL scores were noted, compared with baseline for physical and functional well-being. Emotional well-being scores improved at both assessment 2 and assessment 3. The physical and functional scores returned approximately to baseline values at assessment 3. The change in TOI score was evaluated as a function of the clinical response to treatment, toxicity grade, and survival; no clear association was noted. A trend for the

Can Accelerators Accelerate Learning?

International Nuclear Information System (INIS)

Santos, A. C. F.; Fonseca, P.; Coelho, L. F. S.

2009-01-01

The 'Young Talented' education program developed by the Brazilian State Funding Agency (FAPERJ)[1] makes it possible for high-schools students from public high schools to perform activities in scientific laboratories. In the Atomic and Molecular Physics Laboratory at Federal University of Rio de Janeiro (UFRJ), the students are confronted with modern research tools like the 1.7 MV ion accelerator. Being a user-friendly machine, the accelerator is easily manageable by the students, who can perform simple hands-on activities, stimulating interest in physics, and getting the students close to modern laboratory techniques.

Can Accelerators Accelerate Learning?

Science.gov (United States)

Santos, A. C. F.; Fonseca, P.; Coelho, L. F. S.

2009-03-01

The 'Young Talented' education program developed by the Brazilian State Funding Agency (FAPERJ) [1] makes it possible for high-schools students from public high schools to perform activities in scientific laboratories. In the Atomic and Molecular Physics Laboratory at Federal University of Rio de Janeiro (UFRJ), the students are confronted with modern research tools like the 1.7 MV ion accelerator. Being a user-friendly machine, the accelerator is easily manageable by the students, who can perform simple hands-on activities, stimulating interest in physics, and getting the students close to modern laboratory techniques.

Retractions in cancer research: a systematic survey

OpenAIRE

Bozzo, Anthony; Bali, Kamal; Evaniew, Nathan; Ghert, Michelle

2017-01-01

Background The annual number of retracted publications in the scientific literature is rapidly increasing. The objective of this study was to determine the frequency and reason for retraction of cancer publications and to determine how journals in the cancer field handle retracted articles. Methods We searched three online databases (MEDLINE, Embase, The Cochrane Library) from database inception until 2015 for retracted journal publications related to cancer research. For each article, the re...

Accelerating Translational Research through Open Science: The Neuro Experiment.

Science.gov (United States)

Gold, E Richard

2016-12-01

Translational research is often afflicted by a fundamental problem: a limited understanding of disease mechanisms prevents effective targeting of new treatments. Seeking to accelerate research advances and reimagine its role in the community, the Montreal Neurological Institute (Neuro) announced in the spring of 2016 that it is launching a five-year experiment during which it will adopt Open Science-open data, open materials, and no patenting-across the institution. The experiment seeks to examine two hypotheses. The first is whether the Neuro's Open Science initiative will attract new private partners. The second hypothesis is that the Neuro's institution-based approach will draw companies to the Montreal region, where the Neuro is based, leading to the creation of a local knowledge hub. This article explores why these hypotheses are likely to be true and describes the Neuro's approach to exploring them.

Accelerating Translational Research through Open Science: The Neuro Experiment.

Directory of Open Access Journals (Sweden)

E Richard Gold

2016-12-01

Full Text Available Translational research is often afflicted by a fundamental problem: a limited understanding of disease mechanisms prevents effective targeting of new treatments. Seeking to accelerate research advances and reimagine its role in the community, the Montreal Neurological Institute (Neuro announced in the spring of 2016 that it is launching a five-year experiment during which it will adopt Open Science-open data, open materials, and no patenting-across the institution. The experiment seeks to examine two hypotheses. The first is whether the Neuro's Open Science initiative will attract new private partners. The second hypothesis is that the Neuro's institution-based approach will draw companies to the Montreal region, where the Neuro is based, leading to the creation of a local knowledge hub. This article explores why these hypotheses are likely to be true and describes the Neuro's approach to exploring them.

Recent progress and future direction of cancer epidemiological research in Japan.

Science.gov (United States)

Sobue, Tomotaka

2015-06-01

In 2006, the Cancer Control Act was approved and a Basic Plan, to Promote the Cancer Control Program at the national level, was developed in 2007. Cancer research is recognized as a fundamental component to provide evidence in cancer control program. Cancer epidemiology plays central role in connecting research and policy, since it directly deals with data from humans. Research for cancer epidemiology in Japan made substantial progress, in the field of descriptive studies, cohort studies, intervention studies and activities for summarizing evidences. In future, promoting high-quality large-scale intervention studies, individual-level linkage studies, simulation models and studies for elderly population will be of great importance, but at the same time research should be promoted in well-balanced fashion not placing too much emphasis on one particular research field. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Cancer patient and survivor research from the cancer information service research consortium: a preview of three large randomized trials and initial lessons learned.

Science.gov (United States)

Marcus, Alfred C; Diefenbach, Michael A; Stanton, Annette L; Miller, Suzanne M; Fleisher, Linda; Raich, Peter C; Morra, Marion E; Perocchia, Rosemarie Slevin; Tran, Zung Vu; Bright, Mary Anne

2013-01-01

The authors describe 3 large randomized trials from the Cancer Information Service Research Consortium. Three web-based multimedia programs are being tested to help newly diagnosed prostate (Project 1) and breast cancer patients (Project 2) make informed treatment decisions and breast cancer patients prepare for life after treatment (Project 3). Project 3 also tests a telephone callback intervention delivered by a cancer information specialist. All participants receive standard print material specific to each project. Preliminary results from the 2-month follow-up interviews are reported for the initial wave of enrolled participants, most of whom were recruited from the Cancer Information Service (1-800-4-CANCER) telephone information program (Project 1: n =208; Project 2: n =340; Project 3: n =792). Self-reported use of the multimedia program was 51%, 52%, and 67% for Projects 1, 2, and 3, respectively. Self-reported use of the print materials (read all, most, or some) was 90%, 85%, and 83% for Projects 1, 2, and 3, respectively. The callback intervention was completed by 92% of Project 3 participants. Among those using the Cancer Information Service Research Consortium interventions, perceived usefulness and benefit was high, and more than 90% reported that they would recommend them to other cancer patients. The authors present 5 initial lessons learned that may help inform future cancer communications research.

Research on heightening quality of free electron laser using superconducting linear accelerator

International Nuclear Information System (INIS)

Minehara, Eisuke

1996-01-01

In this paper, the superconducting high frequency linear accelerator technology using low temperature superconductor is introduced, and its application to the heightening of quality of free electron laser is discussed. The high frequency application of superconductivity is a relatively new technology, and the first superconducting high frequency linear accelerator was made at the middle of 1960s. The invention of free electron laser and the development so far are described. In free electron laser, the variation of wavelength, high efficiency and high power output are possible as compared with conventional type lasers. The price and the size are two demerits of free electron laser that remain to the last. In Japan Atomic Energy Research Institute, the adjustment experiment is carried out for the prototype free electron laser. About this prototype, injection system, superconducting accelerator, helium refrigerator, whole solid element high frequency power source, control system, electron beam transport system, undulator system and optical resonator are described. The application of high mean power output free electron laser and its future are discussed. (K.I.)

Shielding design for the target room of the proton accelerator research center

International Nuclear Information System (INIS)

Min, Y. S.; Lee, C. W.; Mun, K. J.; Nam, J.; Kim, J. Y.

2010-01-01

The Proton Engineering Frontier Project (PEFP) has been developing a 100-MeV proton linear accelerator. Also, PEFP has been designing the Proton Accelerator Research Center (PARC). In the Accelerator Tunnel and Beam Experiment Hall in PARC, 10 target rooms for the 20- and 100-MeV beamline facilities exist in the Beam Experiment Hall. For the 100-MeV target rooms during 100-MeV proton beam extraction, a number of high energy neutrons, ranging up to 100-MeV, are produced. Because of the high beam current and space limitations of each target room, the shielding design of each target room should be considered seriously. For the shielding design of the 100-MeV target rooms of the PEFP, a permanent and removable local shield structure was adopted. To optimize shielding performance, we evaluated four different shield materials (concrete, HDPE, lead, iron). From the shielding calculation results, we confirmed that the proposed shielding design made it possible to keep the dose rate below the 'as low as reasonably achievable (ALARA)' objective.

A comparison of cancer burden and research spending reveals discrepancies in the distribution of research funding

Directory of Open Access Journals (Sweden)

Carter Ashley JR

2012-07-01

Full Text Available Abstract Background Ideally, the distribution of research funding for different types of cancer should be equitable with respect to the societal burden each type of cancer imposes. These burdens can be estimated in a variety of ways; “Years of Life Lost” (YLL measures the severity of death in regard to the age it occurs, "Disability-Adjusted Life-Years" (DALY estimates the effects of non-lethal disabilities incurred by disease and economic metrics focus on the losses to tax revenue, productivity or direct medical expenses. We compared research funding from the National Cancer Institute (NCI to a variety of burden metrics for the most common types of cancer to identify mismatches between spending and societal burden. Methods Research funding levels were obtained from the NCI website and information for societal health and economic burdens were collected from government databases and published reports. We calculated the funding levels per unit burden for a wide range of different cancers and burden metrics and compared these values to identify discrepancies. Results Our analysis reveals a considerable mismatch between funding levels and burden. Some cancers are funded at levels far higher than their relative burden suggests (breast cancer, prostate cancer, and leukemia while other cancers appear underfunded (bladder, esophageal, liver, oral, pancreatic, stomach, and uterine cancers. Conclusions These discrepancies indicate that an improved method of health care research funding allocation should be investigated to better match funding levels to societal burden.

Mapping cancer, cardiovascular and malaria research in Brazil

Directory of Open Access Journals (Sweden)

P.S. Rodrigues

2000-08-01

Full Text Available This paper presents performance indicators for the Brazilian cancer, cardiovascular and malaria research areas from 1981 to 1995. The data show an increasing number of papers since 1981 and author numbers indicate a continuous growth of the scientific community and suggest an expected impact of scientific activity on biomedical education. The data also characterize cardiovascular research as a well-established area and cancer research as a faster growing consolidating field. The 1989-1994 share of Brazilian articles among world publications shows a growing trend for the cancer (1.61 and cardiovascular (1.59 areas, and a decrease for the malaria area (0.89. The burden of the three diseases on society is contrasted by the small number of consolidated Brazilian research groups, and a questionable balance of thematic activity, especially with regard to malaria. Brazilian periodicals play an important role in increasing the international visibility of science produced in the country. Cancer and cardiovascular research is strongly concentrated in the Southeastern and in Southern regions of Brazil, especially in São Paulo (at least one address from São Paulo in 64.5% of the 962 cancer articles and in 66.9% of the 2250 cardiovascular articles, the second state being Rio de Janeiro with at least one address in 14.1 and 11% of those articles, respectively. Malaria research (468 articles is more evenly distributed across the country, following the pattern of the endemic distribution of the disease. Surveying these national indicator trends can be useful to establish policies in the decision process about health sciences, medical education and public health.

Quality Control Specialist | Center for Cancer Research

Science.gov (United States)

Within the Leidos Biomedical Research Inc.’s Clinical Research Directorate, the Clinical Monitoring Research Program (CMRP) provides high-quality comprehensive and strategic operational support to the high-profile domestic and international clinical research initiatives of the National Cancer Institute (NCI), National Institute of Allergy and Infectious Diseases (NIAID),

Opportunities for Cancer-relevant Innovative Technologies with Transformative Potential | Office of Cancer Clinical Proteomics Research

Science.gov (United States)

The National Cancer Institute (NCI) is seeking input from the community on identifying priorities with regards to supporting innovative technology development for cancer-relevant research. While the NCI provides support for technology development through a variety of mechanisms, it is important to understand whether or not these are sufficient for catalyzing and supporting the development of tools with significant potential for advancing important fields of cancer research or clinical care.

Statistical Tutorial | Center for Cancer Research

Science.gov (United States)

Recent advances in cancer biology have resulted in the need for increased statistical analysis of research data.  ST is designed as a follow up to Statistical Analysis of Research Data (SARD) held in April 2018.  The tutorial will apply the general principles of statistical analysis of research data including descriptive statistics, z- and t-tests of means and mean

Cellular Basis for ADT-Induced Acceleration of Sarcopenia

Science.gov (United States)

2015-10-01

1 AWARD NUMBER: W81XWH-14-1-0454 TITLE: Cellular Basis for ADT-Induced Acceleration of Sarcopenia PRINCIPAL INVESTIGATOR: Joe V...AND SUBTITLE Cellular Basis for ADT-Induced Acceleration of Sarcopenia 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-14-1-0454 5c. PROGRAM...cell function and thereby regenerative capability contribute to the acceleration of sarcopenia observed in prostate cancer patients undergoing ADT

TL dosimetry in the new Tandetron ion accelerator site of the National Institute of Nuclear Research (ININ)

International Nuclear Information System (INIS)

Valdovinos A, M.; Gonzalez M, P.R.

2000-01-01

The National Institute of Nuclear Research (ININ) acquired a positive ions accelerator type Tandetron 2 MV of the dutch company High Voltage Engineering, Europe B.V., which was finished its installation this year (2000) in an already existing building in the Dr. Nabor Carrillo Flores Nuclear Centre, where it was prepared for the following purposes: the accelerator will be used to realize research through X-ray emission induced by charged particles, Rutherford backscattering analysis, nuclear reaction analysis, gamma ray emission induced by charged particles, resonant dispersion analysis, elastic backward detection analysis and by particle canalization analysis. The accelerator consists of an injection system with two ion sources, ion accelerator tank with voltage in terminal at 2 MV, recovery and recirculation system of charge interchange gas, iman selector analyzer system and with high energy focussing, control system through computer and management and recovery of isolator gas system. For the realization of operation tests of this accelerator, it was had the license authorizing by the National Commission of Nuclear Safety and Safeguards (CNSNS). During the test stage Tl dosemeters were arranged in the Tandetron accelerator area, and also in direction to the beam outlet. In this work, are presented the obtained results of the measurement of radiation levels, as in the area as in the beam outlet. (Author)

Training Program in Biostatistics for Breast Cancer Research

National Research Council Canada - National Science Library

Little, Roderick

1998-01-01

The current training program terminates in the summer of 1998. We had originally planned to develop a training program in biostatistics for cancer research for submission to the National Cancer Institute (Task 9...

Gallic acid induces apoptosis in EGFR-mutant non-small cell lung cancers by accelerating EGFR turnover.

Science.gov (United States)

Nam, Boas; Rho, Jin Kyung; Shin, Dong-Myung; Son, Jaekyoung

2016-10-01

Gallic acid is a common botanic phenolic compound, which is present in plants and foods worldwide. Gallic acid is implicated in various biological processes such as cell growth and apoptosis. Indeed, gallic acid has been shown to induce apoptosis in many cancer types. However, the molecular mechanisms of gallic acid-induced apoptosis in cancer, particularly lung cancer, are still unclear. Here, we report that gallic acid induces apoptosis in EGFR-mutant non-small cell lung cancer (NSCLC) cells, but not in EGFR-WT NSCLC cells. Treatment with gallic acid resulted in a significant reduction in proliferation and induction of apoptosis, only in EGFR-mutant NSCLC cells. Interestingly, treatment with gallic acid led to a robust decrease in EGFR levels, which is critical for NSCLC survival. Treatment with gallic acid had no significant effect on transcription, but induced EGFR turnover. Indeed, treatment with a proteasome inhibitor dramatically reversed gallic acid-induced EGFR downregulation. Moreover, treatment with gallic acid induced EGFR turnover leading to apoptosis in EGFR-TKI (tyrosine kinase inhibitor)-resistant cell lines, which are dependent on EGFR signaling for survival. Thus, these studies suggest that gallic acid can induce apoptosis in EGFR-dependent lung cancers that are dependent on EGFR for growth and survival via acceleration of EGFR turnover. Copyright © 2016 Elsevier Ltd. All rights reserved.

Survey of physics research with a high duty cycle electron accelerator

International Nuclear Information System (INIS)

Bartholomew, G.A.; Earle, E.D.; Knowles, J.W.; Lone, M.A.

1981-02-01

The opportunities for nuclear physics research afforded by a CW electron linac with nominal energy 100 MeV and beam current >= 100 μA equipped with a bremsstrahlung monochromator and reaction product coincidence facilities are outlined. It is proposed that a program toward realization of an accelerator meeting these requirements and with provision for eventual extension to higher energies be undertaken at the Chalk River Nuclear Laboratories. (author)

Accelerator microanalysis

International Nuclear Information System (INIS)

Tuniz, C.

1997-01-01

Particle accelerators have been developed more than sixty years ago to investigate nuclear and atomic phenomena. A major shift toward applications of accelerators in the study of materials structure and composition in inter-disciplinary projects has been witnessed in the last two decades. The Australian Nuclear Science and Technology Organisation (ANSTO) has developed advanced research programs based on the use of particle and photon beams. Atmospheric pollution problems are investigated at the 3 MV Van de Graff accelerator using ion beam analysis techniques to detect toxic elements in aerosol particles. High temperature superconductor and semiconductor materials are characterised using the recoil of iodine and other heavy ions produced at ANTARES, the 10-MV Tandem accelerator. A heavy-ion microprobe is presently being developed at ANTARES to map elemental concentrations of specific elements with micro-size resolution. An Accelerator mass Spectrometry (AMS) system has been developed at ANSTO for the ultra-sensitive detection of Carbon-14, Iodine-129 and other long-lived radioisotopes. This AMS spectrometer is a key instrument for climate change studies and international safeguards. ANSTO is also managing the Australian Synchrotron Research program based on facilities developed at the Photon Factory (Japan) and at the Advanced Photon Source (USA). Advanced projects in biology, materials chemistry, structural condensed matter and other disciplines are being promoted by a consortium involving Australian universities and research institutions. This paper will review recent advances in the use of particle accelerators, with a particular emphasis on applications developed at ANSTO and related to problems of international concern, such as global environmental change, public health and nuclear proliferation

Biopsychosocial Research Training in Breast Cancer

National Research Council Canada - National Science Library

Antoni, Michael

1998-01-01

.... Three others successfully defended their Master's theses. Training throughout YR 4 was closely coordinated with ongoing ACS-funded and NCI-funded biopsychosocial breast cancer research projects...

Nuclear physics accelerator facilities

International Nuclear Information System (INIS)

1988-12-01

This paper describes many of the nuclear physics heavy-ion accelerator facilities in the US and the research programs being conducted. The accelerators described are: Argonne National Laboratory--ATLAS; Brookhaven National Laboratory--Tandem/AGS Heavy Ion Facility; Brookhaven National Laboratory--Relativistic Heavy Ion Collider (RHIC) (Proposed); Continuous Electron Beam Accelerator Facility; Lawrence Berkeley Laboratory--Bevalac; Lawrence Berkeley Laboratory--88-Inch Cyclotron; Los Alamos National Laboratory--Clinton P. Anderson Meson Physics Facility (LAMPF); Massachusetts Institute of Technology--Bates Linear Accelerator Center; Oak Ridge National Laboratory--Holifield Heavy Ion Research Facility; Oak Ridge National Laboratory--Oak Ridge Electron Linear Accelerator; Stanford Linear Accelerator Center--Nuclear Physics Injector; Texas AandM University--Texas AandM Cyclotron; Triangle Universities Nuclear Laboratory (TUNL); University of Washington--Tandem/Superconducting Booster; and Yale University--Tandem Van de Graaff

Accelerated fractionation radiotherapy for advanced haed and neck cancer

International Nuclear Information System (INIS)

Lamb, D.S.; Spry, N.A.; Gray, A.J.; Johnson, A.D.; Alexander, S.R.; Dally, M.J.

1990-01-01

Between 1981 and 1986, 89 patients with advanced head and neck squamous cancer were treated with a continuous accelerated fractionation radiotherapy (AFRT) regimen. Three fractions of 1.80 Gy, 4 h apart, were given on three treatment days per week, and the tumour dose was taken to 59.40 Gy in 33 fractions in 24-25 days. Acute mucosal reactions were generally quite severe, but a split was avoided by providing the patient with intensive support, often as an in-patient, until the reactions settled. Late radiation effects have been comparable to those obtained with conventional fractionation. The probability of local-regional control was 47% at 3 years for 69 previously untreated patients, whereas it was only 12% at one year for 20 patients treated for recurrence after radical surgery. Fifty-eight previously untreated patients with tumours arising in the upper aero-digestive tract were analysed in greated detail. The probability of local-regional control at 3 years was 78% for 17 Stage III patients and 15% for 31 Stage IV patients. This schedule of continuous AFRT is feasible and merits further investigation. (author). 31 refs.; 4 figs.; 6 tabs

Radiological Research Accelerator Facility. Progress report, April 1, 1984-March 31, 1985

International Nuclear Information System (INIS)

Rossi, H.H.

1985-01-01

The aim of the Radiological Research Accelerator Facility (RARAF) was to provide a source of monoenergetic neutrons for studies in radiation biology, dosimetry and microdosimetry. The research has provided insight into the biological action of radiation and its relation to energy distribution in the cell as described by the theory of dual radiation action. This status report on the facility includes descriptions of the capabilities and layout, staffing, radiation safety, and a chronological account of the development and use of the facilities. 5 references, 2 figures

Accelerated ion beam research at ATOMKI

International Nuclear Information System (INIS)

Kiss, A.Z.

2009-01-01

The paper summarizes the studies on accelerated ion beams at ATOMKI and their technical background, their use from chemical analysis to biological, medical, geological, archaeological applications, their advance from material science to micromachining. (TRA)

Challenges in cancer research and multifaceted approaches for cancer biomarker quest

Czech Academy of Sciences Publication Activity Database

Martinková, Jiřina; Gadher, S. J.; Hajduch, M.; Kovářová, Hana

2009-01-01

Roč. 583, - (2009), s. 1772-1784 ISSN 0014-5793 R&D Projects: GA MŠk LC07017 Institutional research plan: CEZ:AV0Z50450515 Keywords : cancer research * proteomics * genomics Subject RIV: FD - Oncology ; Hematology Impact factor: 3.541, year: 2009

Collective ion acceleration

International Nuclear Information System (INIS)

Godfrey, B.B.; Faehl, R.J.; Newberger, B.S.; Shanahan, W.R.; Thode, L.E.

1977-01-01

Progress achieved in the understanding and development of collective ion acceleration is presented. Extensive analytic and computational studies of slow cyclotron wave growth on an electron beam in a helix amplifier were performed. Research included precise determination of linear coupling between beam and helix, suppression of undesired transients and end effects, and two-dimensional simulations of wave growth in physically realizable systems. Electrostatic well depths produced exceed requirements for the Autoresonant Ion Acceleration feasibility experiment. Acceleration of test ions to modest energies in the troughs of such waves was also demonstrated. Smaller efforts were devoted to alternative acceleration mechanisms. Langmuir wave phase velocity in Converging Guide Acceleration was calculated as a function of the ratio of electron beam current to space-charge limiting current. A new collective acceleration approach, in which cyclotron wave phase velocity is varied by modulation of electron beam voltage, is proposed. Acceleration by traveling Virtual Cathode or Localized Pinch was considered, but appears less promising. In support of this research, fundamental investigations of beam propagation in evacuated waveguides, of nonneutral beam linear eigenmodes, and of beam stability were carried out. Several computer programs were developed or enhanced. Plans for future work are discussed

Particle accelerator physics and technology for high energy density physics research

Energy Technology Data Exchange (ETDEWEB)

Hoffmann, D.H.H.; Blazevic, A.; Rosmej, O.N.; Spiller, P.; Tahir, N.A.; Weyrich, K. [Gesellschaft fur Schwerionenforschung, GSI-Darmstadt, Plasmaphysik, Darmstadt (Germany); Hoffmann, D.H.H.; Dafni, T.; Kuster, M.; Ni, P.; Roth, M.; Udrea, S.; Varentsov, D. [Darmstadt Univ., Institut fur Kernphysik, Technische Schlobgartenstr. 9 (Germany); Jacoby, J. [Frankfurt Univ., Institut fur Angewandte Physik (Germany); Kain, V.; Schmidt, R.; Zioutas, K. [European Organization for Nuclear Research (CERN), Geneve (Switzerland); Zioutas, K. [Patras Univ., Dept. of Physics (Greece); Mintsev, V.; Fortov, V.E. [Russian Academy of Sciences, Institute of Problems of Chemical Physics, Chernogolovka (Russian Federation); Sharkov, B.Y. [Institut for Theoretical and Experimental Physics ITEP, Moscow (Russian Federation)

2007-08-15

Interaction phenomena of intense ion- and laser radiation with matter have a large range of application in different fields of science, extending from basic research of plasma properties to applications in energy science, especially in inertial fusion. The heavy ion synchrotron at GSI now routinely delivers intense uranium beams that deposit about 1 kJ/g of specific energy in solid matter, e.g. solid lead. Our simulations show that the new accelerator complex FAIR (Facility for Antiproton and Ion Research) at GSI as well as beams from the CERN large hadron collider (LHC) will vastly extend the accessible parameter range for high energy density states. A natural example of hot dense plasma is provided by our neighbouring star the sun, and allows a deep insight into the physics of fusion, the properties of matter at high energy density, and is moreover an excellent laboratory for astro-particle physics. As such the sun's interior plasma can even be used to probe the existence of novel particles and dark matter candidates. We present an overview on recent results and developments of dense plasma physics addressed with heavy ion and laser beams combined with accelerator- and nuclear physics technology. (authors)

Ascribing emotion to reasonable use in accelerated cancer services.

Science.gov (United States)

Obling, Anne Roelsgaard

2013-01-01

A recurrent theme in medical sociology has been the juxtaposition of emotion with scientific rationality in the delivery of health care services. However, apart from addressing this juxtaposition very little is said about the complex intertwinement of "emotional" and "rational" practices which makes up professionals' own day-to-day work experiences - and how these experiences are influenced by present ways of organising health care. This paper aims to explore the ways that hospital doctors relate emotions to their understanding of professional medical work and how they respond to recent organisational changes within the field. Drawing upon a small series of semi-structured interviews (n = 14) with doctors from a public teaching hospital in Denmark, the paper adopts a constructivist framework to analyse personal biographies of health professionals' working lives. The doctors represented rich accounts of professional medical work, which includes an understanding of what a doctor should feel and how he/she should make him/herself emotionally available to others. However, the impetus for making this appearance was not left unaffected by recent new public management reforms and attempts to accelerate the delivery of services. The organisation of cancer services into a work system, which consists of a set of tasks broken down into narrow jobs, underestimates the emotional components of patient-doctor encounters. This makes the creation and maintenance of a genuine patient-doctor relationship difficult and the result is feelings of a failed encounter on behalf of the doctor. The paper suggests that recent rearrangements of cancer services complicate doctors' ability to incorporate emotion into a stream of medical care in a "rational" way. This is shown to challenge their professional ethos and the forms emotional engagement takes in medical practice.

Heavy ion accelerators

International Nuclear Information System (INIS)

Schmelzer, C.

1974-01-01

This review of the present state of work on heavy-ion accelerators pays particular attention to the requirements for nuclear research. It is divided into the following sections: single-particle versus collective acceleration, heavy-ion accelerators, beam quality, and a status report on the UNILAC facility. Among the topics considered are the recycling cyclotron, linacs with superconducting resonators, and acceleration to the GeV/nucleon range. (8 figures, 2 tables) (U.S.)

Resolving key heavy-ion fusion target issues with relativistic heavy-ion research accelerators

International Nuclear Information System (INIS)

Arnold, R.C.

1988-01-01

Heavy-ion accelerators designed for relativistic nuclear research experiments can also be adapted for target research in heavy-ion driver inertial fusion. Needle-shaped plasmas can be created that are adequate for studying basic properties of matter at high energy density. Although the ion range is very long, the specific deposited power nevertheless increases with kinetic energy, as the focus spot can be made smaller and more ions can be accumulated in larger rings

Eurocan plus report: feasibility study for coordination of national cancer research activities.

Science.gov (United States)

2008-01-01

The EUROCAN+PLUS Project, called for by the European Parliament, was launched in October 2005 as a feasibility study for coordination of national cancer research activities in Europe. Over the course of the next two years, the Project process organized over 60 large meetings and countless smaller meetings that gathered in total over a thousand people, the largest Europe-wide consultation ever conducted in the field of cancer research.Despite a strong tradition in biomedical science in Europe, fragmentation and lack of sustainability remain formidable challenges for implementing innovative cancer research and cancer care improvement. There is an enormous duplication of research effort in the Member States, which wastes time, wastes money and severely limits the total intellectual concentration on the wide cancer problem. There is a striking lack of communication between some of the biggest actors on the European scene, and there are palpable tensions between funders and those researchers seeking funds.It is essential to include the patients' voice in the establishment of priority areas in cancer research at the present time. The necessity to have dialogue between funders and scientists to establish the best mechanisms to meet the needs of the entire community is evident. A top priority should be the development of translational research (in its widest form), leading to the development of effective and innovative cancer treatments and preventive strategies. Translational research ranges from bench-to-bedside innovative cancer therapies and extends to include bringing about changes in population behaviours when a risk factor is established.The EUROCAN+PLUS Project recommends the creation of a small, permanent and independent European Cancer Initiative (ECI). This should be a model structure and was widely supported at both General Assemblies of the project. The ECI should assume responsibility for stimulating innovative cancer research and facilitating processes

Published Research - NCI Alliance for Nanotechnology in Cancer