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Sample records for acads gene variation

  1. Reveal genes functionally associated with ACADS by a network study.

    Science.gov (United States)

    Chen, Yulong; Su, Zhiguang

    2015-09-15

    Establishing a systematic network is aimed at finding essential human gene-gene/gene-disease pathway by means of network inter-connecting patterns and functional annotation analysis. In the present study, we have analyzed functional gene interactions of short-chain acyl-coenzyme A dehydrogenase gene (ACADS). ACADS plays a vital role in free fatty acid β-oxidation and regulates energy homeostasis. Modules of highly inter-connected genes in disease-specific ACADS network are derived by integrating gene function and protein interaction data. Among the 8 genes in ACADS web retrieved from both STRING and GeneMANIA, ACADS is effectively conjoined with 4 genes including HAHDA, HADHB, ECHS1 and ACAT1. The functional analysis is done via ontological briefing and candidate disease identification. We observed that the highly efficient-interlinked genes connected with ACADS are HAHDA, HADHB, ECHS1 and ACAT1. Interestingly, the ontological aspect of genes in the ACADS network reveals that ACADS, HAHDA and HADHB play equally vital roles in fatty acid metabolism. The gene ACAT1 together with ACADS indulges in ketone metabolism. Our computational gene web analysis also predicts potential candidate disease recognition, thus indicating the involvement of ACADS, HAHDA, HADHB, ECHS1 and ACAT1 not only with lipid metabolism but also with infant death syndrome, skeletal myopathy, acute hepatic encephalopathy, Reye-like syndrome, episodic ketosis, and metabolic acidosis. The current study presents a comprehensible layout of ACADS network, its functional strategies and candidate disease approach associated with ACADS network. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential

    DEFF Research Database (Denmark)

    Bross, Peter; Li, Zhijie; Hansen, Jakob

    2007-01-01

    for variations in the HSPD1 and HSPE1 genes encoding the mitochondrial Hsp60/Hsp10 chaperone complex: two patients with multiple mitochondrial enzyme deficiency, 61 sudden infant death syndrome cases (MIM: #272120), and 60 patients presenting with ethylmalonic aciduria carrying non-synonymous susceptibility...... variations in the ACADS gene (MIM: *606885 and #201470). Besides previously reported variations we detected six novel variations: two in the bidirectional promoter region, and one synonymous and three non-synonymous variations in the HSPD1 coding region. One of the non-synonymous variations was polymorphic...... in patient and control samples, and the rare variations were each only found in single patients and absent in 100 control chromosomes. Functional investigation of the effects of the variations in the promoter region and the non-synonymous variations in the coding region indicated that none of them had...

  3. Brain transcriptional responses to high-fat diet in Acads-deficient mice reveal energy sensing pathways.

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    Claudia Kruger

    Full Text Available How signals from fatty acid metabolism are translated into changes in food intake remains unclear. Previously we reported that mice with a genetic inactivation of Acads (acyl-coenzyme A dehydrogenase, short-chain, the enzyme responsible for mitochondrial beta-oxidation of C4-C6 short-chain fatty acids (SCFAs, shift consumption away from fat and toward carbohydrate when offered a choice between diets. In the current study, we sought to indentify candidate genes and pathways underlying the effects of SCFA oxidation deficiency on food intake in Acads-/- mice.We performed a transcriptional analysis of gene expression in brain tissue of Acads-/- and Acads+/+ mice fed either a high-fat (HF or low-fat (LF diet for 2 d. Ingenuity Pathway Analysis revealed three top-scoring pathways significantly modified by genotype or diet: oxidative phosphorylation, mitochondrial dysfunction, and CREB signaling in neurons. A comparison of statistically significant responses in HF Acads-/- vs. HF Acads+/+ (3917 and Acads+/+ HF vs. LF Acads+/+ (3879 revealed 2551 genes or approximately 65% in common between the two experimental comparisons. All but one of these genes were expressed in opposite direction with similar magnitude, demonstrating that HF-fed Acads-deficient mice display transcriptional responses that strongly resemble those of Acads+/+ mice fed LF diet. Intriguingly, genes involved in both AMP-kinase regulation and the neural control of food intake followed this pattern. Quantitative RT-PCR in hypothalamus confirmed the dysregulation of genes in these pathways. Western blotting showed an increase in hypothalamic AMP-kinase in Acads-/- mice and HF diet increased, a key protein in an energy-sensing cascade that responds to depletion of ATP.Our results suggest that the decreased beta-oxidation of short-chain fatty acids in Acads-deficient mice fed HF diet produces a state of energy deficiency in the brain and that AMP-kinase may be the cellular energy

  4. Variation across mitochondrial gene trees provides evidence for systematic error: How much gene tree variation is biological?

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    Richards, Emilie J; Brown, Jeremy M; Barley, Anthony J; Chong, Rebecca A; Thomson, Robert C

    2018-02-19

    The use of large genomic datasets in phylogenetics has highlighted extensive topological variation across genes. Much of this discordance is assumed to result from biological processes. However, variation among gene trees can also be a consequence of systematic error driven by poor model fit, and the relative importance of biological versus methodological factors in explaining gene tree variation is a major unresolved question. Using mitochondrial genomes to control for biological causes of gene tree variation, we estimate the extent of gene tree discordance driven by systematic error and employ posterior prediction to highlight the role of model fit in producing this discordance. We find that the amount of discordance among mitochondrial gene trees is similar to the amount of discordance found in other studies that assume only biological causes of variation. This similarity suggests that the role of systematic error in generating gene tree variation is underappreciated and critical evaluation of fit between assumed models and the data used for inference is important for the resolution of unresolved phylogenetic questions.

  5. Fluxomic evidence for impaired contribution of short-chain acyl-CoA dehydrogenase to mitochondrial palmitate β-oxidation in symptomatic patients with ACADS gene susceptibility variants.

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    Dessein, Anne-Frédérique; Fontaine, Monique; Joncquel-Chevalier Curt, Marie; Briand, Gilbert; Sechter, Claire; Mention-Mulliez, Karine; Dobbelaere, Dries; Douillard, Claire; Lacour, Arnaud; Redonnet-Vernhet, Isabelle; Lamireau, Delphine; Barth, Magalie; Minot-Myhié, Marie-Christine; Kuster, Alice; de Lonlay, Pascale; Gregersen, Niels; Acquaviva, Cécile; Vianey-Saban, Christine; Vamecq, Joseph

    2017-08-01

    Despite ACADS (acyl-CoA dehydrogenase, short-chain) gene susceptibility variants (c.511C>T and c.625G>A) are considered to be non-pathogenic, encoded proteins are known to exhibit altered kinetics. Whether or not, they might affect overall fatty acid β-oxidation still remains, however, unclear. De novo biosynthesis of acylcarnitines by whole blood samples incubated with deuterated palmitate (16- 2 H 3 ,15- 2 H 2 -palmitate) is suitable as a fluxomic exploration to distinguish between normal and disrupted β-oxidation, abnormal profiles and ratios of acylcarnitines with different chain-lengths being indicative of the site for enzymatic blockade. Determinations in 301 control subjects of ratios between deuterated butyrylcarnitine and sum of deuterated C2 to C14 acylcarnitines served here as reference values to state specifically functional SCAD impairment in patients addressed for clinical and/or biological suspicion of a β-oxidation disorder. Functional SCAD impairment was found in 39 patients. The 27 patients accepting subsequent gene studies were all positive for ACADS mutations. Twenty-six of 27 patients were positive for c.625G>A variant. Twenty-three of 27 patients harbored susceptibility variants as sole ACADS alterations (18 homozygous and 3 heterozygous for c.625G>A, 2 compound heterozygous for c.625G>A/c.511C>T). Our present fluxomic assessment of SCAD suggests a link between ACADS susceptibility variants and abnormal β-oxidation consistent with known altered kinetics of these variants. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. rendimiento académico

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    Ernesto Barceló Martínez

    2006-01-01

    Full Text Available Esta investigación se propuso encontrar la posible relación entre el rendimiento académico y la ausencia de ciertas habilidades cognoscitivas denominadas desde la neuropsicología como funciones ejecutivas, en un grupo de estudiantes universitarios. Se exploró entonces el estado de las funciones ejecutivas en estudiantes universitarios que presentaban bajo y alto rendimiento académico. El diseño utilizado en esta investigación fue el transeccional descriptivo. El análisis de los resultados se hizo utilizando el paquete estadístico Statistical Package for Social Sciences (spss. Estos mostraron que, en general, no existen diferencias significativas entre los estudiantes de bajo y alto rendimiento académico. Es decir, mostraron que el rendimiento académico no está directamente relacionado con déficits a nivel de las habilidades ejecutivas, pero sí podría estarlo a nivel del lenguaje y de los antecedentes familiares, psicológicos y académicos en estos estudiantes.

  7. Lifetime exercise intolerance with lactic acidosis as key manifestation of novel compound heterozygous ACAD9 mutations causing complex I deficiency.

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    Schrank, Bertold; Schoser, Benedikt; Klopstock, Thomas; Schneiderat, Peter; Horvath, Rita; Abicht, Angela; Holinski-Feder, Elke; Augustis, Sarunas

    2017-05-01

    We report a 36-year-old female having lifetime exercise intolerance and lactic acidosis with nausea associated with novel compound heterozygous Acyl-CoA dehydrogenase 9 gene (ACAD9) mutations (p.Ala390Thr and p.Arg518Cys). ACAD9 is an assembly factor for the mitochondrial respiratory chain complex I. ACAD9 mutations are recognized as frequent causes of complex I deficiency. Our patient presented with exercise intolerance, rapid fatigue, and nausea since early childhood. Mild physical workload provoked the occurrence of nausea and vomiting repeatedly. Her neurological examination, laboratory findings and muscle biopsy demonstrated no abnormalities. A bicycle spiroergometry provoked significant lactic acidosis during and following exercise pointing towards a mitochondrial disorder. Subsequently, the analysis of respiratory chain enzyme activities in muscle revealed severe isolated complex I deficiency. Candidate gene sequencing revealed two novel heterozygous ACAD9 mutations. This patient report expands the mutational and phenotypic spectrum of diseases associated with mutations in ACAD9. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Parkinson's disease and mitochondrial gene variations

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    Andalib, Sasan; Vafaee, Manouchehr Seyedi; Gjedde, Albert

    2014-01-01

    Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations...

  9. académico en adolescentes

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    Francoise Contreras

    2005-01-01

    Full Text Available Este estudio tuvo como propósito determinar si las variables psicológicas percepción de autoeficacia y ansiedad guardan relación con el rendimiento académico en un grupo de 120 estudiantes de secundaria de un colegio privado de Bogotá. Para ello, se aplicó la Escala de Autoeficacia Generalizada [EAG] y el Cuestionario de Ansiedad Estado - Rasgo [STAI]. Los resultados evidenciaron que la autoeficacia está asociada directamente con el rendimiento académico general, mientras que la ansiedad no. Al examinar por áreas de conocimiento, se encontró que tanto la autoeficacia como la ansiedad resultan ser significativas para la predicción del rendimiento académico. Se discute el papel contextual de la ansiedad así como de su posible mediación en la autoeficacia y el rendimiento académico.

  10. Population genetic variation in gene expression is associated withphenotypic variation in Saccharomyces cerevisiae

    Energy Technology Data Exchange (ETDEWEB)

    Fay, Justin C.; McCullough, Heather L.; Sniegowski, Paul D.; Eisen, Michael B.

    2004-02-25

    The relationship between genetic variation in gene expression and phenotypic variation observable in nature is not well understood. Identifying how many phenotypes are associated with differences in gene expression and how many gene-expression differences are associated with a phenotype is important to understanding the molecular basis and evolution of complex traits. Results: We compared levels of gene expression among nine natural isolates of Saccharomyces cerevisiae grown either in the presence or absence of copper sulfate. Of the nine strains, two show a reduced growth rate and two others are rust colored in the presence of copper sulfate. We identified 633 genes that show significant differences in expression among strains. Of these genes,20 were correlated with resistance to copper sulfate and 24 were correlated with rust coloration. The function of these genes in combination with their expression pattern suggests the presence of both correlative and causative expression differences. But the majority of differentially expressed genes were not correlated with either phenotype and showed the same expression pattern both in the presence and absence of copper sulfate. To determine whether these expression differences may contribute to phenotypic variation under other environmental conditions, we examined one phenotype, freeze tolerance, predicted by the differential expression of the aquaporin gene AQY2. We found freeze tolerance is associated with the expression of AQY2. Conclusions: Gene expression differences provide substantial insight into the molecular basis of naturally occurring traits and can be used to predict environment dependent phenotypic variation.

  11. A role for gene duplication and natural variation of gene expression in the evolution of metabolism.

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    Daniel J Kliebenstein

    Full Text Available BACKGROUND: Most eukaryotic genomes have undergone whole genome duplications during their evolutionary history. Recent studies have shown that the function of these duplicated genes can diverge from the ancestral gene via neo- or sub-functionalization within single genotypes. An additional possibility is that gene duplicates may also undergo partitioning of function among different genotypes of a species leading to genetic differentiation. Finally, the ability of gene duplicates to diverge may be limited by their biological function. METHODOLOGY/PRINCIPAL FINDINGS: To test these hypotheses, I estimated the impact of gene duplication and metabolic function upon intraspecific gene expression variation of segmental and tandem duplicated genes within Arabidopsis thaliana. In all instances, the younger tandem duplicated genes showed higher intraspecific gene expression variation than the average Arabidopsis gene. Surprisingly, the older segmental duplicates also showed evidence of elevated intraspecific gene expression variation albeit typically lower than for the tandem duplicates. The specific biological function of the gene as defined by metabolic pathway also modulated the level of intraspecific gene expression variation. The major energy metabolism and biosynthetic pathways showed decreased variation, suggesting that they are constrained in their ability to accumulate gene expression variation. In contrast, a major herbivory defense pathway showed significantly elevated intraspecific variation suggesting that it may be under pressure to maintain and/or generate diversity in response to fluctuating insect herbivory pressures. CONCLUSION: These data show that intraspecific variation in gene expression is facilitated by an interaction of gene duplication and biological activity. Further, this plays a role in controlling diversity of plant metabolism.

  12. Relación entre burnout y engagement académicos con variables sociodemográficas y académicas

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    Carmen Cecilia Caballero D.

    2015-01-01

    Full Text Available Este estudio buscó esclarecer la interdependencia entre burnout académico ( BA y engagement académico ( EA en estudiantes universitarios del área de la salud, y profundizar en la carac - terización de esta relación a partir de sus asociaciones con variables sociodemográficas y académicas (desempeño académico, DA . Se utilizó un diseño observacional y correlacional de tipo multivariado con una muestra, constituida aleatoria y estratificadamente por 802 estudiantes de los programas de medicina, enfermería, fisioterapia y psicología de universi - dades privadas de Barranquilla, Colombia. Los instrumentos utilizados fueron el MBI - SS , el UWES-S y un cuestionario sobre condiciones socioeconómicas y académicas. El análisis de las relaciones halladas entre BA y EA permitió considerarlos articulados como extremos de un mismo continuo fenoménico o factor, compuesto por las dimensiones de vigor, dedicación, ineficacia académica y cinismo, con valores opuestos en los extremos o polos del factor. Se identificaron variables sociodemográficas y académicas asociadas con los polos del BA y del EA del factor reconocido, donde el BA resultó un buen predictor de mal DA , y el EA un buen predictor de buen DA .

  13. Host genetic variation influences gene expression response to rhinovirus infection.

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    Minal Çalışkan

    2015-04-01

    Full Text Available Rhinovirus (RV is the most prevalent human respiratory virus and is responsible for at least half of all common colds. RV infections may result in a broad spectrum of effects that range from asymptomatic infections to severe lower respiratory illnesses. The basis for inter-individual variation in the response to RV infection is not well understood. In this study, we explored whether host genetic variation is associated with variation in gene expression response to RV infections between individuals. To do so, we obtained genome-wide genotype and gene expression data in uninfected and RV-infected peripheral blood mononuclear cells (PBMCs from 98 individuals. We mapped local and distant genetic variation that is associated with inter-individual differences in gene expression levels (eQTLs in both uninfected and RV-infected cells. We focused specifically on response eQTLs (reQTLs, namely, genetic associations with inter-individual variation in gene expression response to RV infection. We identified local reQTLs for 38 genes, including genes with known functions in viral response (UBA7, OAS1, IRF5 and genes that have been associated with immune and RV-related diseases (e.g., ITGA2, MSR1, GSTM3. The putative regulatory regions of genes with reQTLs were enriched for binding sites of virus-activated STAT2, highlighting the role of condition-specific transcription factors in genotype-by-environment interactions. Overall, we suggest that the 38 loci associated with inter-individual variation in gene expression response to RV-infection represent promising candidates for affecting immune and RV-related respiratory diseases.

  14. Host genetic variation influences gene expression response to rhinovirus infection.

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    Çalışkan, Minal; Baker, Samuel W; Gilad, Yoav; Ober, Carole

    2015-04-01

    Rhinovirus (RV) is the most prevalent human respiratory virus and is responsible for at least half of all common colds. RV infections may result in a broad spectrum of effects that range from asymptomatic infections to severe lower respiratory illnesses. The basis for inter-individual variation in the response to RV infection is not well understood. In this study, we explored whether host genetic variation is associated with variation in gene expression response to RV infections between individuals. To do so, we obtained genome-wide genotype and gene expression data in uninfected and RV-infected peripheral blood mononuclear cells (PBMCs) from 98 individuals. We mapped local and distant genetic variation that is associated with inter-individual differences in gene expression levels (eQTLs) in both uninfected and RV-infected cells. We focused specifically on response eQTLs (reQTLs), namely, genetic associations with inter-individual variation in gene expression response to RV infection. We identified local reQTLs for 38 genes, including genes with known functions in viral response (UBA7, OAS1, IRF5) and genes that have been associated with immune and RV-related diseases (e.g., ITGA2, MSR1, GSTM3). The putative regulatory regions of genes with reQTLs were enriched for binding sites of virus-activated STAT2, highlighting the role of condition-specific transcription factors in genotype-by-environment interactions. Overall, we suggest that the 38 loci associated with inter-individual variation in gene expression response to RV-infection represent promising candidates for affecting immune and RV-related respiratory diseases.

  15. Topological variation in single-gene phylogenetic trees

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    Castresana, Jose

    2007-01-01

    A recent large-scale phylogenomic study has shown the great degree of topological variation that can be found among eukaryotic phylogenetic trees constructed from single genes, highlighting the problems that can be associated with gene sampling in phylogenetic studies.

  16. The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network.

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    David A Garfield

    2013-10-01

    Full Text Available Regulatory interactions buffer development against genetic and environmental perturbations, but adaptation requires phenotypes to change. We investigated the relationship between robustness and evolvability within the gene regulatory network underlying development of the larval skeleton in the sea urchin Strongylocentrotus purpuratus. We find extensive variation in gene expression in this network throughout development in a natural population, some of which has a heritable genetic basis. Switch-like regulatory interactions predominate during early development, buffer expression variation, and may promote the accumulation of cryptic genetic variation affecting early stages. Regulatory interactions during later development are typically more sensitive (linear, allowing variation in expression to affect downstream target genes. Variation in skeletal morphology is associated primarily with expression variation of a few, primarily structural, genes at terminal positions within the network. These results indicate that the position and properties of gene interactions within a network can have important evolutionary consequences independent of their immediate regulatory role.

  17. Partitioning of genetic variation between regulatory and coding gene segments: the predominance of software variation in genes encoding introvert proteins.

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    Mitchison, A

    1997-01-01

    In considering genetic variation in eukaryotes, a fundamental distinction can be made between variation in regulatory (software) and coding (hardware) gene segments. For quantitative traits the bulk of variation, particularly that near the population mean, appears to reside in regulatory segments. The main exceptions to this rule concern proteins which handle extrinsic substances, here termed extrovert proteins. The immune system includes an unusually large proportion of this exceptional category, but even so its chief source of variation may well be polymorphism in regulatory gene segments. The main evidence for this view emerges from genome scanning for quantitative trait loci (QTL), which in the case of the immune system points to a major contribution of pro-inflammatory cytokine genes. Further support comes from sequencing of major histocompatibility complex (Mhc) class II promoters, where a high level of polymorphism has been detected. These Mhc promoters appear to act, in part at least, by gating the back-signal from T cells into antigen-presenting cells. Both these forms of polymorphism are likely to be sustained by the need for flexibility in the immune response. Future work on promoter polymorphism is likely to benefit from the input from genome informatics.

  18. Genomic variation in Salmonella enterica core genes for epidemiological typing

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    Leekitcharoenphon, Pimlapas; Lukjancenko, Oksana; Rundsten, Carsten Friis

    2012-01-01

    Background: Technological advances in high throughput genome sequencing are making whole genome sequencing (WGS) available as a routine tool for bacterial typing. Standardized procedures for identification of relevant genes and of variation are needed to enable comparison between studies and over...... genomes and evaluate their value as typing targets, comparing whole genome typing and traditional methods such as 16S and MLST. A consensus tree based on variation of core genes gives much better resolution than 16S and MLST; the pan-genome family tree is similar to the consensus tree, but with higher...... that there is a positive selection towards mutations leading to amino acid changes. Conclusions: Genomic variation within the core genome is useful for investigating molecular evolution and providing candidate genes for bacterial genome typing. Identification of genes with different degrees of variation is important...

  19. Variation in gene expression within clones of the earthworm Dendrobaena octaedra.

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    Marina Mustonen

    Full Text Available Gene expression is highly plastic, which can help organisms to both acclimate and adapt to changing environments. Possible variation in gene expression among individuals with the same genotype (among clones is not widely considered, even though it could impact the results of studies that focus on gene expression phenotypes, for example studies using clonal lines. We examined the extent of within and between clone variation in gene expression in the earthworm Dendrobaena octaedra, which reproduces through apomictic parthenogenesis. Five microsatellite markers were developed and used to confirm that offspring are genetic clones of their parent. After that, expression of 12 genes was measured from five individuals each from six clonal lines after exposure to copper contaminated soil. Variation in gene expression was higher over all genotypes than within genotypes, as initially assumed. A subset of the genes was also examined in the offspring of exposed individuals in two of the clonal lines. In this case, variation in gene expression within genotypes was as high as that observed over all genotypes. One gene in particular (chymotrypsin inhibitor also showed significant differences in the expression levels among genetically identical individuals. Gene expression can vary considerably, and the extent of variation may depend on the genotypes and genes studied. Ensuring a large sample, with many different genotypes, is critical in studies comparing gene expression phenotypes. Researchers should be especially cautious inferring gene expression phenotypes when using only a single clonal or inbred line, since the results might be specific to only certain genotypes.

  20. Produtivismo acadêmico baseado em uma perspectiva habermasiana

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    Fábio Vizeu

    Full Text Available Resumo Este artigo argumenta que a questão da ética na prática acadêmica deve ser tratada com o mesmo cuidado adotado em outras práticas profissionais. Na verdade, uma dificuldade no debate sobre ética na prática acadêmica é desconsiderar que esta também consiste em uma prática social condicionada pelos mesmos problemas que a sociedade contemporânea enfrenta, especialmente em sua dimensão econômica. Nesse sentido, discute-se o utilitarismo na prática acadêmica com base no referencial da ética discursiva de Jürgen Habermas, explorando algumas inquietações sobre o produtivismo acadêmico brasileiro. Metodologicamente, usa-se o ensaio teórico como procedimento argumentativo, visando à construção de um texto menos formal e mais provocativo, instigando a reflexão e o debate, no meio, das questões pontuadas. Especificamente, observamos o problema da valorização quantitativa da produção sem a consideração da qualidade do trabalho acadêmico associado à tentativa de mensuração da atividade acadêmica, além da falta da devida reflexão sobre os valores ético-morais que circunscrevem a atividade científico-educacional no Brasil. Por último, para ilustrar a perspectiva apresentada, recorremos a situações hipotéticas da prática acadêmica e fazemos inferências sobre quatro correlações entre a orientação pragmática e questões éticas, considerando o constructo habermasiano da ação estratégica.

  1. Variation of clinical expression in patients with Stargardt dystrophy and sequence variations in the ABCR gene.

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    Fishman, G A; Stone, E M; Grover, S; Derlacki, D J; Haines, H L; Hockey, R R

    1999-04-01

    To report the spectrum of ophthalmic findings in patients with Stargardt dystrophy or fundus flavimaculatus who have a specific sequence variation in the ABCR gene. Twenty-nine patients with Stargardt dystrophy or fundus flavimaculatus from different pedigrees were identified with possible disease-causing sequence variations in the ABCR gene from a group of 66 patients who were screened for sequence variations in this gene. Patients underwent a routine ocular examination, including slitlamp biomicroscopy and a dilated fundus examination. Fluorescein angiography was performed on 22 patients, and electroretinographic measurements were obtained on 24 of 29 patients. Kinetic visual fields were measured with a Goldmann perimeter in 26 patients. Single-strand conformation polymorphism analysis and DNA sequencing were used to identify variations in coding sequences of the ABCR gene. Three clinical phenotypes were observed among these 29 patients. In phenotype I, 9 of 12 patients had a sequence change in exon 42 of the ABCR gene in which the amino acid glutamic acid was substituted for glycine (Gly1961Glu). In only 4 of these 9 patients was a second possible disease-causing mutation found on the other ABCR allele. In addition to an atrophic-appearing macular lesion, phenotype I was characterized by localized perifoveal yellowish white flecks, the absence of a dark choroid, and normal electroretinographic amplitudes. Phenotype II consisted of 10 patients who showed a dark choroid and more diffuse yellowish white flecks in the fundus. None exhibited the Gly1961Glu change. Phenotype III consisted of 7 patients who showed extensive atrophic-appearing changes of the retinal pigment epithelium. Electroretinographic cone and rod amplitudes were reduced. One patient showed the Gly1961Glu change. A wide variation in clinical phenotype can occur in patients with sequence changes in the ABCR gene. In individual patients, a certain phenotype seems to be associated with the presence of

  2. Gene copy number variation throughout the Plasmodium falciparum genome

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    Stewart Lindsay B

    2009-08-01

    Full Text Available Abstract Background Gene copy number variation (CNV is responsible for several important phenotypes of the malaria parasite Plasmodium falciparum, including drug resistance, loss of infected erythrocyte cytoadherence and alteration of receptor usage for erythrocyte invasion. Despite the known effects of CNV, little is known about its extent throughout the genome. Results We performed a whole-genome survey of CNV genes in P. falciparum using comparative genome hybridisation of a diverse set of 16 laboratory culture-adapted isolates to a custom designed high density Affymetrix GeneChip array. Overall, 186 genes showed hybridisation signals consistent with deletion or amplification in one or more isolate. There is a strong association of CNV with gene length, genomic location, and low orthology to genes in other Plasmodium species. Sub-telomeric regions of all chromosomes are strongly associated with CNV genes independent from members of previously described multigene families. However, ~40% of CNV genes were located in more central regions of the chromosomes. Among the previously undescribed CNV genes, several that are of potential phenotypic relevance are identified. Conclusion CNV represents a major form of genetic variation within the P. falciparum genome; the distribution of gene features indicates the involvement of highly non-random mutational and selective processes. Additional studies should be directed at examining CNV in natural parasite populations to extend conclusions to clinical settings.

  3. Meiotic gene-conversion rate and tract length variation in the human genome.

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    Padhukasahasram, Badri; Rannala, Bruce

    2013-02-27

    Meiotic recombination occurs in the form of two different mechanisms called crossing-over and gene-conversion and both processes have an important role in shaping genetic variation in populations. Although variation in crossing-over rates has been studied extensively using sperm-typing experiments, pedigree studies and population genetic approaches, our knowledge of variation in gene-conversion parameters (ie, rates and mean tract lengths) remains far from complete. To explore variability in population gene-conversion rates and its relationship to crossing-over rate variation patterns, we have developed and validated using coalescent simulations a comprehensive Bayesian full-likelihood method that can jointly infer crossing-over and gene-conversion rates as well as tract lengths from population genomic data under general variable rate models with recombination hotspots. Here, we apply this new method to SNP data from multiple human populations and attempt to characterize for the first time the fine-scale variation in gene-conversion parameters along the human genome. We find that the estimated ratio of gene-conversion to crossing-over rates varies considerably across genomic regions as well as between populations. However, there is a great degree of uncertainty associated with such estimates. We also find substantial evidence for variation in the mean conversion tract length. The estimated tract lengths did not show any negative relationship with the local heterozygosity levels in our analysis.European Journal of Human Genetics advance online publication, 27 February 2013; doi:10.1038/ejhg.2013.30.

  4. Genetic spectrum of low density lipoprotein receptor gene variations in South Indian population.

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    ArulJothi, K N; Suruthi Abirami, B; Devi, Arikketh

    2018-03-01

    Low density lipoprotein receptor (LDLR) is a membrane bound receptor maintaining cholesterol homeostasis along with Apolipoprotein B (APOB), Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) and other genes of lipid metabolism. Any pathogenic variation in these genes alters the function of the receptor and leads to Familial Hypercholesterolemia (FH) and other cardiovascular diseases. This study was aimed at screening the LDLR, APOB and PCSK9 genes in Hypercholesterolemic patients to define the genetic spectrum of FH in Indian population. Familial Hypercholesterolemia patients (n=78) of South Indian Tamil population with LDL cholesterol and Total cholesterol levels above 4.9mmol/l and 7.5mmol/l with family history of Myocardial infarction were involved. DNA was isolated by organic extraction method from blood samples and LDLR, APOB and PCSK9 gene exons were amplified using primers that cover exon-intron boundaries. The amplicons were screened using High Resolution Melt (HRM) Analysis and the screened samples were sequenced after purification. This study reports 20 variations in South Indian population for the first time. In this set of variations 9 are novel variations which are reported for the first time, 11 were reported in other studies also. The in silico analysis for all the variations detected in this study were done to predict the probabilistic effect in pathogenicity of FH. This study adds 9 novel variations and 11 recurrent variations to the spectrum of LDLR gene mutations in Indian population. All these variations are reported for the first time in Indian population. This spectrum of variations was different from the variations of previous Indian reports. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster

    Science.gov (United States)

    Carreira, Valeria Paula; Mensch, Julián; Hasson, Esteban; Fanara, Juan José

    2016-01-01

    Body size is a complex character associated to several fitness related traits that vary within and between species as a consequence of environmental and genetic factors. Latitudinal and altitudinal clines for different morphological traits have been described in several species of Drosophila and previous work identified genomic regions associated with such variation in D. melanogaster. However, the genetic factors that orchestrate morphological variation have been barely studied. Here, our main objective was to investigate genetic variation for different morphological traits associated to the second chromosome in natural populations of D. melanogaster along latitudinal and altitudinal gradients in Argentina. Our results revealed weak clinal signals and a strong population effect on morphological variation. Moreover, most pairwise comparisons between populations were significant. Our study also showed important within-population genetic variation, which must be associated to the second chromosome, as the lines are otherwise genetically identical. Next, we examined the contribution of different candidate genes to natural variation for these traits. We performed quantitative complementation tests using a battery of lines bearing mutated alleles at candidate genes located in the second chromosome and six second chromosome substitution lines derived from natural populations which exhibited divergent phenotypes. Results of complementation tests revealed that natural variation at all candidate genes studied, invected, Fasciclin 3, toucan, Reticulon-like1, jing and CG14478, affects the studied characters, suggesting that they are Quantitative Trait Genes for morphological traits. Finally, the phenotypic patterns observed suggest that different alleles of each gene might contribute to natural variation for morphological traits. However, non-additive effects cannot be ruled out, as wild-derived strains differ at myriads of second chromosome loci that may interact

  6. Pulmonary phenotypes associated with genetic variation in telomere-related genes.

    Science.gov (United States)

    Hoffman, Thijs W; van Moorsel, Coline H M; Borie, Raphael; Crestani, Bruno

    2018-05-01

    Genomic mutations in telomere-related genes have been recognized as a cause of familial forms of idiopathic pulmonary fibrosis (IPF). However, it has become increasingly clear that telomere syndromes and telomere shortening are associated with various types of pulmonary disease. Additionally, it was found that also single nucleotide polymorphisms (SNPs) in telomere-related genes are risk factors for the development of pulmonary disease. This review focuses on recent updates on pulmonary phenotypes associated with genetic variation in telomere-related genes. Genomic mutations in seven telomere-related genes cause pulmonary disease. Pulmonary phenotypes associated with these mutations range from many forms of pulmonary fibrosis to emphysema and pulmonary vascular disease. Telomere-related mutations account for up to 10% of sporadic IPF, 25% of familial IPF, 10% of connective-tissue disease-associated interstitial lung disease, and 1% of COPD. Mixed disease forms have also been found. Furthermore, SNPs in TERT, TERC, OBFC1, and RTEL1, as well as short telomere length, have been associated with several pulmonary diseases. Treatment of pulmonary disease caused by telomere-related gene variation is currently based on disease diagnosis and not on the underlying cause. Pulmonary phenotypes found in carriers of telomere-related gene mutations and SNPs are primarily pulmonary fibrosis, sometimes emphysema and rarely pulmonary vascular disease. Genotype-phenotype relations are weak, suggesting that environmental factors and genetic background of patients determine disease phenotypes to a large degree. A disease model is presented wherever genomic variation in telomere-related genes cause specific pulmonary disease phenotypes whenever triggered by environmental exposure, comorbidity, or unknown factors.

  7. Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation

    Directory of Open Access Journals (Sweden)

    Hines Heather M

    2012-06-01

    Full Text Available Abstract Background Heliconius butterfly wing pattern diversity offers a unique opportunity to investigate how natural genetic variation can drive the evolution of complex adaptive phenotypes. Positional cloning and candidate gene studies have identified a handful of regulatory and pigmentation genes implicated in Heliconius wing pattern variation, but little is known about the greater developmental networks within which these genes interact to pattern a wing. Here we took a large-scale transcriptomic approach to identify the network of genes involved in Heliconius wing pattern development and variation. This included applying over 140 transcriptome microarrays to assay gene expression in dissected wing pattern elements across a range of developmental stages and wing pattern morphs of Heliconius erato. Results We identified a number of putative early prepattern genes with color-pattern related expression domains. We also identified 51 genes differentially expressed in association with natural color pattern variation. Of these, the previously identified color pattern “switch gene” optix was recovered as the first transcript to show color-specific differential expression. Most differentially expressed genes were transcribed late in pupal development and have roles in cuticle formation or pigment synthesis. These include previously undescribed transporter genes associated with ommochrome pigmentation. Furthermore, we observed upregulation of melanin-repressing genes such as ebony and Dat1 in non-melanic patterns. Conclusions This study identifies many new genes implicated in butterfly wing pattern development and provides a glimpse into the number and types of genes affected by variation in genes that drive color pattern evolution.

  8. Gene transposition causing natural variation for growth in Arabidopsis thaliana.

    Science.gov (United States)

    Vlad, Daniela; Rappaport, Fabrice; Simon, Matthieu; Loudet, Olivier

    2010-05-13

    A major challenge in biology is to identify molecular polymorphisms responsible for variation in complex traits of evolutionary and agricultural interest. Using the advantages of Arabidopsis thaliana as a model species, we sought to identify new genes and genetic mechanisms underlying natural variation for shoot growth using quantitative genetic strategies. More quantitative trait loci (QTL) still need be resolved to draw a general picture as to how and where in the pathways adaptation is shaping natural variation and the type of molecular variation involved. Phenotypic variation for shoot growth in the Bur-0 x Col-0 recombinant inbred line set was decomposed into several QTLs. Nearly-isogenic lines generated from the residual heterozygosity segregating among lines revealed an even more complex picture, with major variation controlled by opposite linked loci and masked by the segregation bias due to the defective phenotype of SG3 (Shoot Growth-3), as well as epistasis with SG3i (SG3-interactor). Using principally a fine-mapping strategy, we have identified the underlying gene causing phenotypic variation at SG3: At4g30720 codes for a new chloroplast-located protein essential to ensure a correct electron flow through the photosynthetic chain and, hence, photosynthesis efficiency and normal growth. The SG3/SG3i interaction is the result of a structural polymorphism originating from the duplication of the gene followed by divergent paralogue's loss between parental accessions. Species-wide, our results illustrate the very dynamic rate of duplication/transposition, even over short periods of time, resulting in several divergent--but still functional-combinations of alleles fixed in different backgrounds. In predominantly selfing species like Arabidopsis, this variation remains hidden in wild populations but is potentially revealed when divergent individuals outcross. This work highlights the need for improved tools and algorithms to resolve structural variation

  9. Variations in IBD (ACAD8) in children with elevated C4-carnitine detected by tandem mass spectrometry newborn screening

    DEFF Research Database (Denmark)

    Pedersen, Christina B; Bischoff, Claus; Christensen, Ernst

    2006-01-01

    or compound heterozygous for variations in the IBD gene have been reported. We present IBD deficiency in an additional four newborns with elevated C(4)-carnitine identified by tandem mass spectrometry (MS/MS) screening in Denmark and the United States. Three showed urinary excretions of isobutyryl...

  10. La gestión de conocimiento en las relaciones académico-empresariales. Un nuevo enfoque para analizar el impacto del conocimiento académico

    OpenAIRE

    FUENTES MORALES, BULMARO ADRIÁN

    2011-01-01

    La necesidad de introducir las teorías basadas en el conocimiento para explicar las Relaciones Académico-Empresariales (RA-E) y el impacto que ha generado el conocimiento académico en su zona de influencia, llamese empresas, parte básicamente de los señalamientos que hacia Acs, et al., (1991: 363) con respecto a la incapacidad de los estudios económicos para reconocer qué modos y mecanismos de transmisión de conocimientos se dan lugar entre la investigación académica y las empresas debido a l...

  11. Conceptual Variation or Incoherence? Textbook Discourse on Genes in Six Countries

    Science.gov (United States)

    Gericke, Niklas M.; Hagberg, Mariana; dos Santos, Vanessa Carvalho; Joaquim, Leyla Mariane; El-Hani, Charbel N.

    2014-01-01

    The aim of this paper is to investigate in a systematic and comparative way previous results of independent studies on the treatment of genes and gene function in high school textbooks from six different countries. We analyze how the conceptual variation within the scientific domain of Genetics regarding gene function models and gene concepts is…

  12. Regulatory Architecture of Gene Expression Variation in the Threespine Stickleback Gasterosteus aculeatus

    Directory of Open Access Journals (Sweden)

    Victoria L. Pritchard

    2017-01-01

    Full Text Available Much adaptive evolutionary change is underlain by mutational variation in regions of the genome that regulate gene expression rather than in the coding regions of the genes themselves. An understanding of the role of gene expression variation in facilitating local adaptation will be aided by an understanding of underlying regulatory networks. Here, we characterize the genetic architecture of gene expression variation in the threespine stickleback (Gasterosteus aculeatus, an important model in the study of adaptive evolution. We collected transcriptomic and genomic data from 60 half-sib families using an expression microarray and genotyping-by-sequencing, and located expression quantitative trait loci (eQTL underlying the variation in gene expression in liver tissue using an interval mapping approach. We identified eQTL for several thousand expression traits. Expression was influenced by polymorphism in both cis- and trans-regulatory regions. Trans-eQTL clustered into hotspots. We did not identify master transcriptional regulators in hotspot locations: rather, the presence of hotspots may be driven by complex interactions between multiple transcription factors. One observed hotspot colocated with a QTL recently found to underlie salinity tolerance in the threespine stickleback. However, most other observed hotspots did not colocate with regions of the genome known to be involved in adaptive divergence between marine and freshwater habitats.

  13. Servicios Académicos Del Programa De Acceso Inclusivo, Equidad Y Permanencia: Impacto En El Rendimiento Académico 2015

    OpenAIRE

    Fredes, Pablo; Cornejo, María Francisca; Urbina, Loreto; Villaroel, Mirza; González, Francisca

    2016-01-01

    Dado que la Universidad de Santiago de Chile tiene para el proceso de admisión una alta valoración por la trayectoria académica (40% Ranking-10% NEM), los estudiantes que ingresan a la Universidad son en general estudiantes talentosos que han aprovechado al máximo las oportunidades en su contexto, sin embargo, las tasas de cobertura curricular de los establecimientos de los que provienen son bajas; por este motivo la Universidad les ofrece a estos estudiantes nivelación y acompañamiento acadé...

  14. Natural variation of rice blast resistance gene Pi-d2

    Science.gov (United States)

    Studying natural variation of rice resistance (R) genes in cultivated and wild rice relatives can predict resistance stability to rice blast fungus. In the present study, the protein coding regions of rice R gene Pi-d2 in 35 rice accessions of subgroups, aus (AUS), indica (IND), temperate japonica (...

  15. Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness.

    Science.gov (United States)

    Kerwin, Rachel; Feusier, Julie; Corwin, Jason; Rubin, Matthew; Lin, Catherine; Muok, Alise; Larson, Brandon; Li, Baohua; Joseph, Bindu; Francisco, Marta; Copeland, Daniel; Weinig, Cynthia; Kliebenstein, Daniel J

    2015-04-13

    Natural populations persist in complex environments, where biotic stressors, such as pathogen and insect communities, fluctuate temporally and spatially. These shifting biotic pressures generate heterogeneous selective forces that can maintain standing natural variation within a species. To directly test if genes containing causal variation for the Arabidopsis thaliana defensive compounds, glucosinolates (GSL) control field fitness and are therefore subject to natural selection, we conducted a multi-year field trial using lines that vary in only specific causal genes. Interestingly, we found that variation in these naturally polymorphic GSL genes affected fitness in each of our environments but the pattern fluctuated such that highly fit genotypes in one trial displayed lower fitness in another and that no GSL genotype or genotypes consistently out-performed the others. This was true both across locations and within the same location across years. These results indicate that environmental heterogeneity may contribute to the maintenance of GSL variation observed within Arabidopsis thaliana.

  16. Genome-wide associations of gene expression variation in humans.

    Directory of Open Access Journals (Sweden)

    Barbara E Stranger

    2005-12-01

    Full Text Available The exploration of quantitative variation in human populations has become one of the major priorities for medical genetics. The successful identification of variants that contribute to complex traits is highly dependent on reliable assays and genetic maps. We have performed a genome-wide quantitative trait analysis of 630 genes in 60 unrelated Utah residents with ancestry from Northern and Western Europe using the publicly available phase I data of the International HapMap project. The genes are located in regions of the human genome with elevated functional annotation and disease interest including the ENCODE regions spanning 1% of the genome, Chromosome 21 and Chromosome 20q12-13.2. We apply three different methods of multiple test correction, including Bonferroni, false discovery rate, and permutations. For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs with expression variation in lymphoblastoid cell lines after correcting for multiple tests. Based on our analyses, the signal proximal (cis- to the genes of interest is more abundant and more stable than distal and trans across statistical methodologies. Our results suggest that regulatory polymorphism is widespread in the human genome and show that the 5-kb (phase I HapMap has sufficient density to enable linkage disequilibrium mapping in humans. Such studies will significantly enhance our ability to annotate the non-coding part of the genome and interpret functional variation. In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level.

  17. Genome-Wide Associations of Gene Expression Variation in Humans.

    Directory of Open Access Journals (Sweden)

    2005-12-01

    Full Text Available The exploration of quantitative variation in human populations has become one of the major priorities for medical genetics. The successful identification of variants that contribute to complex traits is highly dependent on reliable assays and genetic maps. We have performed a genome-wide quantitative trait analysis of 630 genes in 60 unrelated Utah residents with ancestry from Northern and Western Europe using the publicly available phase I data of the International HapMap project. The genes are located in regions of the human genome with elevated functional annotation and disease interest including the ENCODE regions spanning 1% of the genome, Chromosome 21 and Chromosome 20q12-13.2. We apply three different methods of multiple test correction, including Bonferroni, false discovery rate, and permutations. For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs with expression variation in lymphoblastoid cell lines after correcting for multiple tests. Based on our analyses, the signal proximal (cis- to the genes of interest is more abundant and more stable than distal and trans across statistical methodologies. Our results suggest that regulatory polymorphism is widespread in the human genome and show that the 5-kb (phase I HapMap has sufficient density to enable linkage disequilibrium mapping in humans. Such studies will significantly enhance our ability to annotate the non-coding part of the genome and interpret functional variation. In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level.

  18. Regulatory Architecture of Gene Expression Variation in the Threespine Stickleback Gasterosteus aculeatus.

    Science.gov (United States)

    Pritchard, Victoria L; Viitaniemi, Heidi M; McCairns, R J Scott; Merilä, Juha; Nikinmaa, Mikko; Primmer, Craig R; Leder, Erica H

    2017-01-05

    Much adaptive evolutionary change is underlain by mutational variation in regions of the genome that regulate gene expression rather than in the coding regions of the genes themselves. An understanding of the role of gene expression variation in facilitating local adaptation will be aided by an understanding of underlying regulatory networks. Here, we characterize the genetic architecture of gene expression variation in the threespine stickleback (Gasterosteus aculeatus), an important model in the study of adaptive evolution. We collected transcriptomic and genomic data from 60 half-sib families using an expression microarray and genotyping-by-sequencing, and located expression quantitative trait loci (eQTL) underlying the variation in gene expression in liver tissue using an interval mapping approach. We identified eQTL for several thousand expression traits. Expression was influenced by polymorphism in both cis- and trans-regulatory regions. Trans-eQTL clustered into hotspots. We did not identify master transcriptional regulators in hotspot locations: rather, the presence of hotspots may be driven by complex interactions between multiple transcription factors. One observed hotspot colocated with a QTL recently found to underlie salinity tolerance in the threespine stickleback. However, most other observed hotspots did not colocate with regions of the genome known to be involved in adaptive divergence between marine and freshwater habitats. Copyright © 2017 Pritchard et al.

  19. Influencia de la autoeficacia académica y la procrastinación académica sobre el cansancio emocional de estudiantes de la Universidad Alas Peruanas, Lima, 2015

    OpenAIRE

    Gutiérrez Torres, Andrés Martín

    2015-01-01

    Objetivo: determinar cuánta es la influencia de la autoeficacia académica y la procrastinación académica sobre el cansancio emocional de estudiantes de la Universidad Alas Peruanas, Lima, 2015. Metodología: se usó un diseño observacional, transversal, retrospectivo y correlacional-causal. La muestra no probabilística fue de 332 estudiantes de Psicología de una universidad privada de Lima, quienes fueron evaluados con tres instrumentos: Escala de Autoeficacia para Situaciones Académicas, E...

  20. Transcriptomic variation among six Arabidopsis thaliana accessions identified several novel genes controlling aluminium tolerance.

    Science.gov (United States)

    Kusunoki, Kazutaka; Nakano, Yuki; Tanaka, Keisuke; Sakata, Yoichi; Koyama, Hiroyuki; Kobayashi, Yuriko

    2017-02-01

    Differences in the expression levels of aluminium (Al) tolerance genes are a known determinant of Al tolerance among plant varieties. We combined transcriptomic analysis of six Arabidopsis thaliana accessions with contrasting Al tolerance and a reverse genetic approach to identify Al-tolerance genes responsible for differences in Al tolerance between accession groups. Gene expression variation increased in the signal transduction process under Al stress and in growth-related processes in the absence of stress. Co-expression analysis and promoter single nucleotide polymorphism searching suggested that both trans-acting polymorphisms of Al signal transduction pathway and cis-acting polymorphisms in the promoter sequences caused the variations in gene expression associated with Al tolerance. Compared with the wild type, Al sensitivity increased in T-DNA knockout (KO) lines for five genes, including TARGET OF AVRB OPERATION1 (TAO1) and an unannotated gene (At5g22530). These were identified from 53 Al-inducible genes showing significantly higher expression in tolerant accessions than in sensitive accessions. These results indicate that the difference in transcriptional signalling is partly associated with the natural variation in Al tolerance in Arabidopsis. Our study also demonstrates the feasibility of comparative transcriptome analysis by using natural genetic variation for the identification of genes responsible for Al stress tolerance. © 2016 John Wiley & Sons Ltd.

  1. Analysis of Copy Number Variation in the Abp Gene Regions of Two House Mouse Subspecies Suggests Divergence during the Gene Family Expansions.

    Science.gov (United States)

    Pezer, Željka; Chung, Amanda G; Karn, Robert C; Laukaitis, Christina M

    2017-06-01

    The Androgen-binding protein ( Abp ) gene region of the mouse genome contains 64 genes, some encoding pheromones that influence assortative mating between mice from different subspecies. Using CNVnator and quantitative PCR, we explored copy number variation in this gene family in natural populations of Mus musculus domesticus ( Mmd ) and Mus musculus musculus ( Mmm ), two subspecies of house mice that form a narrow hybrid zone in Central Europe. We found that copy number variation in the center of the Abp gene region is very common in wild Mmd , primarily representing the presence/absence of the final duplications described for the mouse genome. Clustering of Mmd individuals based on this variation did not reflect their geographical origin, suggesting no population divergence in the Abp gene cluster. However, copy number variation patterns differ substantially between Mmd and other mouse taxa. Large blocks of Abp genes are absent in Mmm , Mus musculus castaneus and an outgroup, Mus spretus , although with differences in variation and breakpoint locations. Our analysis calls into question the reliance on a reference genome for interpreting the detailed organization of genes in taxa more distant from the Mmd reference genome. The polymorphic nature of the gene family expansion in all four taxa suggests that the number of Abp genes, especially in the central gene region, is not critical to the survival and reproduction of the mouse. However, Abp haplotypes of variable length may serve as a source of raw genetic material for new signals influencing reproductive communication and thus speciation of mice. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  2. Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness

    Science.gov (United States)

    Kerwin, Rachel; Feusier, Julie; Corwin, Jason; Rubin, Matthew; Lin, Catherine; Muok, Alise; Larson, Brandon; Li, Baohua; Joseph, Bindu; Francisco, Marta; Copeland, Daniel; Weinig, Cynthia; Kliebenstein, Daniel J

    2015-01-01

    Natural populations persist in complex environments, where biotic stressors, such as pathogen and insect communities, fluctuate temporally and spatially. These shifting biotic pressures generate heterogeneous selective forces that can maintain standing natural variation within a species. To directly test if genes containing causal variation for the Arabidopsis thaliana defensive compounds, glucosinolates (GSL) control field fitness and are therefore subject to natural selection, we conducted a multi-year field trial using lines that vary in only specific causal genes. Interestingly, we found that variation in these naturally polymorphic GSL genes affected fitness in each of our environments but the pattern fluctuated such that highly fit genotypes in one trial displayed lower fitness in another and that no GSL genotype or genotypes consistently out-performed the others. This was true both across locations and within the same location across years. These results indicate that environmental heterogeneity may contribute to the maintenance of GSL variation observed within Arabidopsis thaliana. DOI: http://dx.doi.org/10.7554/eLife.05604.001 PMID:25867014

  3. Calidad del dormir, insomnio y rendimiento académico en estudiantes de medicina

    Directory of Open Access Journals (Sweden)

    Alvaro Monterrosa Castro

    2015-01-01

    Full Text Available Es alta la prevalencia de mala calidad del sueño en estudiantes universitarios, especialmente de medicina. Los disturbios del dormir repercuten de manera negativa en la salud mental, física y en la calidad de vida. El objetivo es evaluar la calidad del dormir e insomnio y su asociación con el rendimiento académico, en estudiantes de medicina de una universidad pública del Caribe Colombiano. Estudio transversal, realizado en estudiantes de primero a décimo semestre de medicina de la Universidad de Cartagena, Colombia. Se aplicó formulario de datos socio demográfico y académico, así como la Escala de Insomnio de Atenas y el índice de calidad de sueño de Pittsburgh. Puntuación de Atenas > 5 indica insomnio y Pittsburgh >5: malos dormidores. Participación voluntaria, estratificada por sexo y semestre. Los datos fueron analizados con Epi-Info 7. Valor de p<0.05 estadísticamente significativo. Participaron 210 estudiantes. Edad: 19.7±2.0. Varones: 49.0%, procedentes de Cartagena: 69%. Promedio académico: 3.8±0.2. Rendimiento académico alto: 31.4%. Se estimaron como malos dormidores el 88.1%. No se observaron diferencias significativas entre buenos dormidores y malos dormidores en cuanto a rendimiento académico. El 46.6% presentaban insomnio. Los estudiantes con rendimiento académico alto, tuvieron significativamente menor presencia de insomnio. Los estudiantes con insomnio y malos dormidores tuvieron presencia significativamente mayor de somnolencia diurna. Se concluye que en estudiantes de medicina de una universidad colombiana fue elevada la presencia de malos dormidores, pero ello no se asoció con el rendimiento académico. El insomnio también fue elevadamente prevalente y si tuvo asociación significativa con el rendimiento académico.

  4. Temporal gene expression variation associated with eyespot size plasticity in Bicyclus anynana.

    Directory of Open Access Journals (Sweden)

    Jeffrey C Oliver

    Full Text Available Seasonal polyphenism demonstrates an organism's ability to respond to predictable environmental variation with alternative phenotypes, each presumably better suited to its respective environment. However, the molecular mechanisms linking environmental variation to alternative phenotypes via shifts in development remain relatively unknown. Here we investigate temporal gene expression variation in the seasonally polyphenic butterfly Bicyclus anynana. This species shows drastic changes in eyespot size depending on the temperature experienced during larval development. The wet season form (larvae reared over 24°C has large ventral wing eyespots while the dry season form (larvae reared under 19°C has much smaller eyespots. We compared the expression of three proteins, Notch, Engrailed, and Distal-less, in the future eyespot centers of the two forms to determine if eyespot size variation is associated with heterochronic shifts in the onset of their expression. For two of these proteins, Notch and Engrailed, expression in eyespot centers occurred earlier in dry season than in wet season larvae, while Distal-less showed no temporal difference between the two forms. These results suggest that differences between dry and wet season adult wings could be due to a delay in the onset of expression of these eyespot-associated genes. Early in eyespot development, Notch and Engrailed may be functioning as repressors rather than activators of the eyespot gene network. Alternatively, temporal variation in the onset of early expressed genes between forms may have no functional consequences to eyespot size regulation and may indicate the presence of an 'hourglass' model of development in butterfly eyespots.

  5. Variation-preserving normalization unveils blind spots in gene expression profiling

    Science.gov (United States)

    Roca, Carlos P.; Gomes, Susana I. L.; Amorim, Mónica J. B.; Scott-Fordsmand, Janeck J.

    2017-01-01

    RNA-Seq and gene expression microarrays provide comprehensive profiles of gene activity, but lack of reproducibility has hindered their application. A key challenge in the data analysis is the normalization of gene expression levels, which is currently performed following the implicit assumption that most genes are not differentially expressed. Here, we present a mathematical approach to normalization that makes no assumption of this sort. We have found that variation in gene expression is much larger than currently believed, and that it can be measured with available assays. Our results also explain, at least partially, the reproducibility problems encountered in transcriptomics studies. We expect that this improvement in detection will help efforts to realize the full potential of gene expression profiling, especially in analyses of cellular processes involving complex modulations of gene expression. PMID:28276435

  6. Competencias profesionales de los académicos en la educación superior

    Directory of Open Access Journals (Sweden)

    Guillermo Yáber Oltra

    2011-06-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2011v4n1p129   El desarrollo profesional de los profesores y los líderes universitarios es un proceso continuo en la educación superior. Docencia, investigación, servicio, desarrollo personal y gestión son las competencias profesionales que un académico puede desarrollar durante su carrera. Se desarrolló un instrumento de auto-reporte que permite analizar la discrepancia entre la maestría que el personal académico y directivo aprecia de sus competencias académicas, personales y de gestión así como la importancia que la institución les asigna. Se presentan dos casos de instituciones donde estos instrumentos se aplicaron a gerentes y académicos. Se analiza el uso de este instrumento para el desarrollo de políticas y prácticas de gestión del talento académico y gerencial de las instituciones de Educación Superior.

  7. Estrés académico y funcionalidad familiar en estudiantes de odontología

    Directory of Open Access Journals (Sweden)

    Shyrley Díaz Cárdenas

    2014-01-01

    Full Text Available Objetivo: Asociar estrés académico y funcionalidad familiar en estudiantes de odontología. Metodología: Estudio de corte transversal en una muestra probabilística de 251 estudiantes de odontología de una universidad pública de Cartagena de Indias (Colombia. Se midieron características sociodemográficas, estrés académico (escala SISCO y funcionalidad familiar (APGAR familiar. Se estimó ocurrencia (prevalencias, asociación entre variables (odd ratios y análisis multivariable (regresión logística nominal. Resultados: El estrés académico se presentó en 87,3 % de los estudiantes; la situación más estresante en el entorno académico fue la evaluación docente; la disfuncionalidad familiar se comportó como un factor asociado para el estrés académico (OR=2,32. En el análisis de regresión logística, el modelo que mejor que explica el estrés académico estuvo conformado por los siguientes factores: la participación familiar, sexo y ciclo académico cursado (p= 0,0001; X2= 22,9. Conclusiones: La disfuncionalidad familiar puede agravar las situaciones de estrés académico en estudiantes de odontología e influir en su rendimiento académico, lo que ameritaría la necesidad de una atención permanente a la relación entre el entorno familiar y la universidad en aras del desarrollo integral de los universitarios.

  8. Aprendizaje autorregulado, metas académicas y rendimiento en evaluaciones de estudiantes universitarios

    Directory of Open Access Journals (Sweden)

    Marcela Valencia Serrano

    2013-01-01

    Full Text Available Objetivo. Explorar la relación entre aprendizaje autorregulado, metas académicas y rendimiento en una evaluación académica de ocho estudiantes universitarias. Método. Se realizó una entrevista semi- estructurada, una observación directa de una sesión de estudio y protocolos verbales durante y después de la sesión. Resultados. En relación con las metas académicas, se encontró que tres estudiantes tuvieron u na única orientación a metas de dominio por aproximación, mientras que cinco orien taron a múltiples metas académicas. Respecto al aprendizaje autorregulado, se encontraron estudiantes con b ajos y altos niveles. En la relación entre aprendizaje autorregulado, metas académicas y rendimiento en la evaluación fue posible identificar tres grupos de estudiantes: (a altos niveles de autorregulación y orientación única a metas de dominio por aproximación, (b bajos niveles de autorregulación y múltipl e orientación a metas de dominio y ejecución en tendencias de aproximación y evitación, y (c variaciones en el nivel de autorregulación con múltiple orientación a metas académicas. Todas las estudiantes obtuvieron cali ficaciones aprobatorias en la evaluación, independientemente de su nivel de autorregulación y de la orientaci ón a metas académicas. Conclusión. El abordaje procedimental del aprendizaje autorregulado, en función de las metas académicas, permitió obtener información relevante para la comprensión de este proceso, por lo que se recomienda seguir realizando este tipo de estudios para dar cuenta de los diferentes fu ncionamientos de las estudiantes universitarias en tiempo real, de sus variaciones y relación con otros aspectos motivacionales involucrados en sus procesos de aprendizaje.

  9. Genomic Features That Predict Allelic Imbalance in Humans Suggest Patterns of Constraint on Gene Expression Variation

    Science.gov (United States)

    Fédrigo, Olivier; Haygood, Ralph; Mukherjee, Sayan; Wray, Gregory A.

    2009-01-01

    Variation in gene expression is an important contributor to phenotypic diversity within and between species. Although this variation often has a genetic component, identification of the genetic variants driving this relationship remains challenging. In particular, measurements of gene expression usually do not reveal whether the genetic basis for any observed variation lies in cis or in trans to the gene, a distinction that has direct relevance to the physical location of the underlying genetic variant, and which may also impact its evolutionary trajectory. Allelic imbalance measurements identify cis-acting genetic effects by assaying the relative contribution of the two alleles of a cis-regulatory region to gene expression within individuals. Identification of patterns that predict commonly imbalanced genes could therefore serve as a useful tool and also shed light on the evolution of cis-regulatory variation itself. Here, we show that sequence motifs, polymorphism levels, and divergence levels around a gene can be used to predict commonly imbalanced genes in a human data set. Reduction of this feature set to four factors revealed that only one factor significantly differentiated between commonly imbalanced and nonimbalanced genes. We demonstrate that these results are consistent between the original data set and a second published data set in humans obtained using different technical and statistical methods. Finally, we show that variation in the single allelic imbalance-associated factor is partially explained by the density of genes in the region of a target gene (allelic imbalance is less probable for genes in gene-dense regions), and, to a lesser extent, the evenness of expression of the gene across tissues and the magnitude of negative selection on putative regulatory regions of the gene. These results suggest that the genomic distribution of functional cis-regulatory variants in the human genome is nonrandom, perhaps due to local differences in evolutionary

  10. A comprehensive review of the prevalence of beta globin gene variations and the co-inheritance of related gene variants in Saudi Arabians with beta-thalassemia

    Science.gov (United States)

    Alaithan, Mousa A.; AbdulAzeez, Sayed; Borgio, J. Francis

    2018-01-01

    Beta-thalassemia is a genetic disorder that is caused by variations in the beta-hemoglobin (HBB) gene. Saudi Arabia is among the countries most affected by beta-thalassemia, and this is particularly problematic in the Eastern regions. This review article is an attempt to compile all the reported mutations to facilitate further national-level studies to prepare a Saudi repository of HBB gene variations. In Saudi Arabians, IVSI-5 (G>C) and Cd 39 (C>T) are the most prevalent HBB gene variations out of 42 variations. The coinheritance of HBB gene variations with ATRX, HBA1, HBA2, HBA12, AHSP, and KLF1 gene variations were observed to be common in the Saudi population. National surveys on the molecular nature of hemoglobinopathies should be set up through collaborations between research centers from various regions to create a well-documented molecular data bank. This data bank can be used to develop a premarital screening program and lead to the best treatment and prevention strategies for beta-thalassemia. PMID:29619482

  11. Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

    Science.gov (United States)

    Solus, Joseph F; Arietta, Brenda J; Harris, James R; Sexton, David P; Steward, John Q; McMunn, Chara; Ihrie, Patrick; Mehall, Janelle M; Edwards, Todd L; Dawson, Elliott P

    2004-10-01

    The extent of genetic variation found in drug metabolism genes and its contribution to interindividual variation in response to medication remains incompletely understood. To better determine the identity and frequency of variation in 11 phase I drug metabolism genes, the exons and flanking intronic regions of the cytochrome P450 (CYP) isoenzyme genes CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP3A5 were amplified from genomic DNA and sequenced. A total of 60 kb of bi-directional sequence was generated from each of 93 human DNAs, which included Caucasian, African-American and Asian samples. There were 388 different polymorphisms identified. These included 269 non-coding, 45 synonymous and 74 non-synonymous polymorphisms. Of these, 54% were novel and included 176 non-coding, 14 synonymous and 21 non-synonymous polymorphisms. Of the novel variants observed, 85 were represented by single occurrences of the minor allele in the sample set. Much of the variation observed was from low-frequency alleles. Comparatively, these genes are variation-rich. Calculations measuring genetic diversity revealed that while the values for the individual genes are widely variable, the overall nucleotide diversity of 7.7 x 10(-4) and polymorphism parameter of 11.5 x 10(-4) are higher than those previously reported for other gene sets. Several independent measurements indicate that these genes are under selective pressure, particularly for polymorphisms corresponding to non-synonymous amino acid changes. There is relatively little difference in measurements of diversity among the ethnic groups, but there are large differences among the genes and gene subfamilies themselves. Of the three CYP subfamilies involved in phase I drug metabolism (1, 2, and 3), subfamily 2 displays the highest levels of genetic diversity.

  12. Plagio e integridad académica en Alemania

    Directory of Open Access Journals (Sweden)

    2016-07-01

    Full Text Available Alemania es quizá uno de los países europeos que, ya desde el siglo XVIII, ha mantenido un debate público más intenso sobre prácticas científicas y académicas deshonestas, relacionadas especialmente con tesis doctorales. Este debate fue especialmente productivo a finales del siglo XIX, dando lugar desde entonces, para evitar estas prácticas inaceptables, a la obligatoriedad de publicar todas las tesis doctorales, como requisito previo a la expedición del título de doctor por cualquier universidad alemana. Este trabajo analiza los avances más importantes en plagio e integridad académica en Alemania, especialmente después del escándalo surgido en 2011 a raíz del plagio de la tesis doctoral del Ministro de Defensa Guttenberg, como son la creación de una eficaz metodología colaborativa de investigación del plagio en trabajos científicos o académicos utilizando Internet y las redes sociales, materializada en la Wiki «VroniPlag». También se describe someramente en este trabajo la consolidación definitiva de la figura del «Defensor de la Ciencia», como instrumento de ámbito nacional para prevenir, gestionar y combatir la deshonestidad científica, aparte de la publicación en 2013 de una nueva versión del manual de referencia al respecto «Sicherung guter wissenschaftlicher Praxis». Por último se analizan las conclusiones de la experiencia alemana relacionada con la ética académica, también desde una perspectiva histórica, pues sus recientes logros y avances pueden servir de referencia a otros países europeos.

  13. Usos de Internet y éxito académico en estudiantes universitarios

    Directory of Open Access Journals (Sweden)

    2016-07-01

    Full Text Available El uso de la tecnología provoca cambios sociales. Esto incluye el trabajo en el ámbito universitario en donde está cambiando tanto la forma de ejercer la docencia como la forma de aprender y se requiere conocer el efecto del uso de la tecnología sobre el rendimiento del alumnado. En este trabajo se investigó la incidencia del uso de Internet sobre el éxito académico del alumnado de cinco universidades de Ecuador. Se levantó una muestra aleatoria de 4.697 personas y se las categorizó en perfiles de uso de Internet para actividades académicas y para entretenimiento, utilizando análisis factorial y análisis clúster. Las categorías resultantes se utilizaron como variables independientes en modelos de regresión logística multinomial que buscaban determinar si el uso de Internet tenía incidencia sobre el éxito académico. Los resultados muestran que quienes realizan actividades interactivas con pares y profesores o quienes utilizan de forma balanceada las distintas herramientas de Internet tienden a un mayor éxito académico que aquellos que solo buscan información. En lo referente al entretenimiento, se encontró una incidencia positiva del uso de Internet sobre el éxito académico. Los estudiantes que realizan descargas de contenido de audio, video y software, y quienes utilizan todas las posibilidades de entretenimiento, presentan menor tendencia a suspender que los estudiantes que utilizan mínimamente Internet. En cuanto al género se presentan diferencias en los usos académicos y de entretenimiento.

  14. Flagellar-phase variation: isolation of the rh1 gene

    International Nuclear Information System (INIS)

    Silverman, M.; Zieg, J.; Simon, M.

    1979-01-01

    In Salmonella, expression of flagellar antigen alternates between two serotypes (phases) encoded by two genes, H1 and H2. The mechanism which controls the alternative expression of the H1 and H2 genes was examined by cloning these genes and the genetic elements which control their activity on hybrid vehicles in Escherichia coli. H2 gene activity was shown to be controlled by a recombinational switch located adjacent to the H2 gene. Activity of the H1 gene is thought to be repressed, when the H2 gene is expressed, by the product of another gene, rhl (repressor of H1), which is controlled coordinately with the H2 gene. In this report, we describe the construction of hybrid lambda vehicles which contain, in addition to the H2 gene, a genetic activity corresponding to rhl. Variation of flagellar antigens analogous to that observed in Salmonella was observed when E. coli strains were transduced with the hybrid lambda. By using the lambda H2rhl hybrid to program protein syntheis in uv-irradiated cells, the synthesis of a polypeptide was correlated with rhl gene product activity. We conclude that the H2 region consists of two cotranscribed genes, H2 and rhl. The expression of both gene products is regulated by the same recombinational event

  15. Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans

    Directory of Open Access Journals (Sweden)

    Hunter Gary R

    2008-08-01

    Full Text Available Abstract Background The objective of the present study was to map candidate loci influencing naturally occurring variation in triacylglycerol (TAG storage using quantitative complementation procedures in Drosophila melanogaster. Based on our results from Drosophila, we performed a human population-based association study to investigate the effect of natural variation in LAMA5 gene on body composition in humans. Results We identified four candidate genes that contributed to differences in TAG storage between two strains of D. melanogaster, including Laminin A (LanA, which is a member of the α subfamily of laminin chains. We confirmed the effects of this gene using a viable LanA mutant and showed that female flies homozygous for the mutation had significantly lower TAG storage, body weight, and total protein content than control flies. Drosophila LanA is closely related to human LAMA5 gene, which maps to the well-replicated obesity-linkage region on chromosome 20q13.2-q13.3. We tested for association between three common single nucleotide polymorphisms (SNPs in the human LAMA5 gene and variation in body composition and lipid profile traits in a cohort of unrelated women of European American (EA and African American (AA descent. In both ethnic groups, we found that SNP rs659822 was associated with weight (EA: P = 0.008; AA: P = 0.05 and lean mass (EA: P= 0.003; AA: P = 0.03. We also found this SNP to be associated with height (P = 0.01, total fat mass (P = 0.01, and HDL-cholesterol (P = 0.003 but only in EA women. Finally, significant associations of SNP rs944895 with serum TAG levels (P = 0.02 and HDL-cholesterol (P = 0.03 were observed in AA women. Conclusion Our results suggest an evolutionarily conserved role of a member of the laminin gene family in contributing to variation in weight and body composition.

  16. Genomic and gene variation in Mycoplasma hominis strains

    DEFF Research Database (Denmark)

    Christiansen, Gunna; Andersen, H; Birkelund, Svend

    1987-01-01

    DNAs from 14 strains of Mycoplasma hominis isolated from various habitats, including strain PG21, were analyzed for genomic heterogeneity. DNA-DNA filter hybridization values were from 51 to 91%. Restriction endonuclease digestion patterns, analyzed by agarose gel electrophoresis, revealed...... no identity or cluster formation between strains. Variation within M. hominis rRNA genes was analyzed by Southern hybridization of EcoRI-cleaved DNA hybridized with a cloned fragment of the rRNA gene from the mycoplasma strain PG50. Five of the M. hominis strains showed identical hybridization patterns....... These hybridization patterns were compared with those of 12 other mycoplasma species, which showed a much more complex band pattern. Cloned nonribosomal RNA gene fragments of M. hominis PG21 DNA were analyzed, and the fragments were used to demonstrate heterogeneity among the strains. A monoclonal antibody against...

  17. La inteligencia emocional y el rendimiento académico

    OpenAIRE

    Sandoval, M.; Castro, R.

    2016-01-01

    A partir de que Goleman la da a conocer en los años 90´s, se ha explorado, y realizado investigación sobre la inteligencia emocional (I.E.); en el ámbito académico hay múltiples trabajos que afirman que existe una correlación entre dicha inteligencia y el rendimiento académico. Para Salovey et al. Inteligencia emocional es un conjunto de competencias que abarca la evaluación, expresión y uso de emociones, para facilitar las actividades cognitivas, el conocimiento acerca de las emociones y la ...

  18. Vida académica de la facultad

    Directory of Open Access Journals (Sweden)

    Facultad de Medicina Revista

    1999-10-01

    Full Text Available Distinciones académicas / Novedades docentes / Libro' 'Manual de Rehabilitación Médica" / Texto de Obstetricia y Perinatología / xv Curso Anual Medicina Interna / Libros Publicados en la Facultad de Medicina Universidad Nacional De Colombia, 1999.

  19. Implicación familiar, autoconcepto del adolescente y rendimiento académico

    Directory of Open Access Journals (Sweden)

    Ana Álvarez

    2015-12-01

    Full Text Available El objetivo de este trabajo fue analizar la relación específica entre las diferentes formas de implicación familiar, las dimensiones del autoconcepto del estudiante y su rendimiento académico. En el estudio han participado 503 estudiantes de la Enseñanza Secundaria Obligatoria (ESO y el primer curso de Bachillerato. Los datos fueron recogidos a través de dos inventarios (Cuestionario de Implicación Familiar –CIF-, Escala de Evaluación del Autoconcepto -ESEA-2 y las calificaciones académicas. Los datos fueron analizados mediante análisis multivariados de la varianza y a través de análisis de senderos. Los resultados mostraron relación significativa entre las dimensiones de la implicación familiar percibida y las dimensiones del autoconcepto, excepto el reforzamiento de logro. Por otra parte, la relación entre implicación familiar percibida y rendimiento académico es mediada parcialmente por el autoconcepto académico.

  20. Modelo Explicativo del Desempeño Académico desde la Autoeficacia y los Problemas de Conducta

    Directory of Open Access Journals (Sweden)

    Virgelina Castellanos Páez

    2017-02-01

    Full Text Available Se analizó un modelo explicativo del desempeño académico para conocer si los problemas de atención median la relación entre la autoeficacia académica y el desempeño académico, y si la ansiedad y la depresión moderan dicha relación. Participaron 326 estudiantes (11-18 años, quienes diligenciaron el Youth Self-Report (Achenback & Rescorla, 2001 y la escala de autoeficacia de Aguilar, Valencia y Martínez (2001. El desempeño académico se obtuvo del promedio de calificaciones de dos bimestres académicos en lenguaje, ciencias y matemáticas. El análisis de regresión mostró que los problemas de atención median la relación entre la autoeficacia, explicando el 40% de la varianza. La variable ansiedad-depresión moderó esta misma relación evidenciando que, a mayores niveles de ansiedad y de depresión, menor autoeficacia académica y menor desempeño académico. En suma, la relación entre la autoeficacia académica y el desempeño académico fue afectada por los problemas de conducta.

  1. Global and disease-associated genetic variation in the human Fanconi anemia gene family.

    Science.gov (United States)

    Rogers, Kai J; Fu, Wenqing; Akey, Joshua M; Monnat, Raymond J

    2014-12-20

    Fanconi anemia (FA) is a human recessive genetic disease resulting from inactivating mutations in any of 16 FANC (Fanconi) genes. Individuals with FA are at high risk of developmental abnormalities, early bone marrow failure and leukemia. These are followed in the second and subsequent decades by a very high risk of carcinomas of the head and neck and anogenital region, and a small continuing risk of leukemia. In order to characterize base pair-level disease-associated (DA) and population genetic variation in FANC genes and the segregation of this variation in the human population, we identified 2948 unique FANC gene variants including 493 FA DA variants across 57,240 potential base pair variation sites in the 16 FANC genes. We then analyzed the segregation of this variation in the 7578 subjects included in the Exome Sequencing Project (ESP) and the 1000 Genomes Project (1KGP). There was a remarkably high frequency of FA DA variants in ESP/1KGP subjects: at least 1 FA DA variant was identified in 78.5% (5950 of 7578) individuals included in these two studies. Six widely used functional prediction algorithms correctly identified only a third of the known, DA FANC missense variants. We also identified FA DA variants that may be good candidates for different types of mutation-specific therapies. Our results demonstrate the power of direct DNA sequencing to detect, estimate the frequency of and follow the segregation of deleterious genetic variation in human populations. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. vocacional y esfuerzo académico

    Directory of Open Access Journals (Sweden)

    Daniel González Lomelí

    2005-01-01

    Full Text Available El objetivo del presente estudio fue determinar si existen relaciones entre las variables latentes, factores de carrera, seguridad vocacional y el esfuerzo académico en una muestra constituida por 229 estudiantes de primer semestre de las Licenciaturas en Psicología y Químico-Biólogos de una universidad pública. Se utilizó el Inventario Ampliado de Factores de Carrera (IAFC. Se realizaron análisis estadísticos descriptivos de las variables demográficas y análisis factoriales de ecuaciones estructurales para las variables descritas en el modelo teórico. Se logró conformar un modelo multifactorial de Factores de Carrera que explica 33% de la varianza de la seguridad vocacional y 10% de la varianza del esfuerzo académico. El modelo presenta bondad de ajuste y sugiere el desarrollo de tecnología educativa mediante el uso de instrumentos diagnósticos que permitan diferenciar al estudiantado vocacionalmente “seguro” del “inseguro” en poblaciones universitarias similares a la muestra estudiada

  3. A leitura acadêmica na formação docente: dificuldades e possibilidades

    Directory of Open Access Journals (Sweden)

    Antônio Lailton Moraes Duarte

    2016-01-01

    Full Text Available Este artigo objetiva refletir sobre a importância da leitura para formação docente no tocante a aspectos relacionados à frequência, aos objetivos e aos interesses de leitura acadêmica. Para tanto, fundamentamo-nos, principalmente, nas obras de Kramer (2002, Cavalcante Jr. (2005a,b, Freire (1993 e Matêncio (1994. Para sua execução, contamos com a participação de alunos de um curso de Pedagogia, matriculados em uma disciplina do sétimo semestre da Universidade Estadual do Ceará. Os estudantes preencheram um questionário com questões relacionadas ao seu perfil-leitor eàs dificuldades e possibilidades de leitura acadêmica na universidade. Os resultados demonstram que a leitura de textos acadêmicos deve ser um componente para que os alunospossam obter novos aprendizados. Além do mais, a leitura acadêmica de textos que relacionam teoria e prática deve ser constante para que o futuro profissional possa basear, conforme Farias (2009, a sua ação docente no conhecimento elaborado e na realidade dada a fim de formar habilidades interlocutivas na leitura. Assim, os professores universitáriosdevem priorizar textos do interesse dos alunos para que estes possam lê-los estabelecendo seus objetivos de leitura e também percebendo laços com sua prática profissional, uma vezque o uso frequente de procedimentos metacognitivos são exigidos durante a leitura de textos acadêmicos.Palavras-chave: Leitura; formação de professores; discurso acadêmico.

  4. Escritura y argumentación académica: trayectorias estudiantiles, factores docentes y contextuales (Academic Writing and Argumentation: Trajectories Student-Teachers and Contextual Factors (Ecriture et argumentation académique: trajectoires, facteurs enseignants et contextuels (Escrita e argumentação acadêmica: trajetórias estudantis, fatores docentes e contextuais

    Directory of Open Access Journals (Sweden)

    Constanza Padilla

    2012-12-01

    Full Text Available ResumenEn el presente artículo de investigación, intentamos contribuir a la discusión sobre las alternativas para ocuparse de la escritura académica en la Universi- dad. Articulamos aportes teóricos sobre escritura y argumentación, al atender a sus potencialidades epis- témicas. El objetivo es ponderar el impacto de inter- venciones docentes y de factores contextuales en las trayectorias de estudiantes principiantes y avanzados de una universidad pública argentina que participaron o no, de programas de alfabetización académica. Me- diante triangulación de datos, comprobamos proviso- riamente dos hipótesis de trabajo: la relación entre la calidad de los escritos académicos estudiantiles y una intervención didáctica sistemática, y la incidencia de diversos factores contextuales en los itinerarios acadé- micos estudiantiles.AbstractIn this research paper we try to contri- bute to the discussion on alternatives to deal with academic writing in colle- ge. Theoretical studies articulate wri- ting and argumentation, according to their epistemic potentialities. The aim is to assess the impact of educational interventions and contextual factors in the trajectories of beginners and ad- vanced students of a public university involving Argentina or not, academic literacy programs. By triangulating data, we test two hypotheses tempo- rarily work: the relationship between the quality of student academic wri- ting and systematic educational inter- vention, and the incidence of various contextual factors on student learning paths.RésuméDans le présent article de recherche on essaye de contribuer au débat par rapport aux alternatives de s'occu- per de l'écriture académique à l'Uni- versité. On articule les contributions théoriques par rapport à l'écriture et l'argumentation, en faisant attention aux potentielles épistémiques. L’objec- tif est pondérer l'impact des interven- tions des enseignants et de facteurs contextuelles dans

  5. Motivação e envolvimento acadêmico: um estudo com estudantes universitários

    Directory of Open Access Journals (Sweden)

    Rebeca Cruz Porto

    Full Text Available Resumo Pesquisas sugerem que motivação e envolvimento acadêmico sejam variáveis importantes para o contexto educacional. Assim, a presente pesquisa teve por objetivo principal investigar a relação entre estes construtos. A amostra foi composta por 406 estudantes universitários, a maioria (81,3% com idades variando entre 20 e 30 anos, do sexo feminino (55,2% e de instituições de ensino superior pública (70,4%. Estes responderam a Escala de Motivação Acadêmica (EMA, a Escala de Envolvimento Acadêmico (EEA e a questões sociodemográficas. Os resultados apontaram correlação positiva e significativa entre motivação e envolvimento acadêmico. Foram encontradas ainda diferenças em relação ao sexo, ao período e área do curso e ao envolvimento com atividades extracurriculares. Tais resultados foram discutidos à luz das teorias do envolvimento acadêmico e da autodeterminação. Sugere-se a realização de novas pesquisas a fim de melhor compreender as variáveis que influenciam na motivação e no envolvimento acadêmico de estudantes universitários.

  6. Violência: conceito e vivência entre acadêmicos da área da saúde

    Directory of Open Access Journals (Sweden)

    Rosiléia Rosa

    Full Text Available Trata-se de uma investigação sobre conceitos e vivências sobre violência de acadêmicos do último ano dos cursos de graduação em Enfermagem, Medicina e Odontologia da Universidade Federal de Santa Catarina. Caracterizada como uma pesquisa descritiva exploratória com abordagem qualiquantitativa com 175 acadêmicos, a proposta foi compreender qual a definição de violência para os acadêmicos, quais suas vivências sobre o tema e qual a inserção que o tema violência teve durante a formação acadêmica. As definições sobre violência estiveram fortemente relacionadas a uma visão técnica e priorizaram os danos físicos sofridos pelas pessoas agredidas. Diante de uma situação de violência os acadêmicos reproduziram sentimentos de medo, impotência, raiva e indignação e não reagiram ao presenciar tais atos; evidenciaram que o profissional de saúde não identifica situações de violência quando presta assistência de forma superficial às vítimas; e que a formação acadêmica não discute o tema suficientemente.

  7. Genetic variation at Exon2 of TLR4 gene and its association with ...

    African Journals Online (AJOL)

    This study was conducted to analyze the polymorphisms of chicken Toll-like receptors 4(TLR4) gene and aimed to provide a theoretical foundation for a further research on correlation between chicken TLR4 gene and disease resistance. Genetic variations at exon 2 of TLR4 gene in 14 chicken breeds and the red jungle ...

  8. Theories of Population Variation in Genes and Genomes

    DEFF Research Database (Denmark)

    Christiansen, Freddy

    This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world’s leading authorities in the field, the book focuses on the theoretical background of population...... genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately...... connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are discussed with reference to molecular genetic variation. The book is designed for students of population genetics, bioinformatics, evolutionary biology, molecular evolution, and theoretical biology—as well...

  9. La superación en gestión académica del directivo universitario

    Directory of Open Access Journals (Sweden)

    Vicenta Aveiga Macay

    2013-12-01

    Full Text Available Se planteó como objetivo sistematizar los fundamentos teóricos que sustentan el proceso de superación a directivos universitarios para la gestión académica. Se utilizó métodos del nivel teórico y empírico como el histórico lógico, analítico-sintético, el análisis documental, la observación, el inventario de dificultades, cuestionarios, entrevistas, los cuales posibilitaron caracterizar epistemológicamente el proceso de superación a directivos universitarios con énfasis en la gestión académica, arribar a nuevos conceptos, y distinguir aspectos significativos de la superación a directivos en gestión académica. PALABRAS CLAVES: Directivos, gestión académica, proceso formativo, superación.

  10. Variation in the PTEN-induced putative kinase 1 gene associated ...

    Indian Academy of Sciences (India)

    with the increase risk of type 2 diabetes in northern Chinese. YANCHUN QU1†∗ ... and genetic variation analysis have indicated the involvement of PINK1 gene in the ... Qualitative variables were analysed by a chi-squared test. The level of ...

  11. Positive association of vitamin D receptor gene variations with multiple sclerosis in South East Iranian population.

    Science.gov (United States)

    Narooie-Nejad, Mehrnaz; Moossavi, Maryam; Torkamanzehi, Adam; Moghtaderi, Ali

    2015-01-01

    Among the factors postulated to play a role in MS susceptibility, the role of vitamin D is outstanding. Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim to highlight the association of two VDR gene polymorphisms with MS susceptibility. In current study, we recruited 113 MS patients and 122 healthy controls. TaqI (rs731236) and ApaI (rs7975232) genetic variations in these two groups were evaluated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. All genotype and allele frequencies in both variations showed association with the disease status. However, to find the definite connection between genetic variations in VDR gene and MS disease in a population of South East of Iran, more researches on gene structure and its function with regard to patients' conditions are required.

  12. O preparo dos acadêmicos de enfermagem brasileiros para vivenciarem o processo morte-morrer

    OpenAIRE

    Bernieri, Jamine; Hirdes, Alice

    2007-01-01

    Esta pesquisa teve como objetivo geral investigar o preparo dos acadêmicos de enfermagem frente à morte. A metodologia é de natureza qualitativa, realizada através de 15 entrevistas semi-estruturadas com acadêmicos de Enfermagem do sexto e sétimo semestres de uma instituição de ensino superior localizada no norte do Rio Grande do Sul. Os resultados apontam as dificuldades dos acadêmicos de enfermagem entrevistados em lidar com o processo morte-morrer dos pacientes assistidos em estágio; a dif...

  13. Factores asociados al rendimiento académico en estudiantes de medicina

    Directory of Open Access Journals (Sweden)

    Alberto Vélez van Meerbeke

    Full Text Available Objetivos: Determinar y evaluar los factores que estuvieran incidiendo en el desempeño académico de nuestros estudiantes de primer semestre de medicina. Metodología: Se caracterizó la población en búsqueda de factores que se analizaron posteriormente para determinar asociación y predicción, a través de un modelo de regresión logística, del rendimiento académico final. Resultados: Se analizaron 80 estudiantes de edades comprendidas entre 17 y 18, la mayoría mujeres, procedentes de Bogotá, de colegios mixtos, privados y monolingües. El grupo fue homogéneo por factores sociodemográficos, culturales, escolaridad y de motivaciones. Se detectaron rasgos de violencia intrafamiliar, de consumo de alcohol y cigarrillo pero no de drogas psicoactivas. Los resultados obtenidos en la prueba de aptitudes diferenciales y generales (BADyGs del aprendizaje fueron bajos. El análisis mostró que el no leer como pasatiempo, la presencia de violencia intrafamiliar, el haber fumado marihuana, el provenir de un colegio mixto, el no haber realizado estudios profesionales, de quien se depende económicamente, las notas de biología, bioquímica y del promedio trimestral fueron los factores que se asocian con fracaso académico o pérdida de cupo. La variable que predice fracaso académico cuando se controla por los otros factores incluidos en el modelo es el promedio trimestral y la que determina pérdida de cupo es la nota del laboratorio de bioquímica. Conclusiones: Aunque existen factores previos al ingreso que puedan explicar el desempeño académico, es importante evaluar el rendimiento durante el semestre para intervenir rápidamente y evitar el fracaso.

  14. Resiliencia, optimismo y burnout académico en estudiantes universitarios

    Directory of Open Access Journals (Sweden)

    Carmen Vizoso-Gómez

    2018-06-01

    Full Text Available En este estudio se analiza la relación entre la resiliencia, el optimismo disposicional y las dimensiones que constituyen el burnout académico (agotamiento emocional, cinismo y baja eficacia. Para ello, se evaluó a una muestra formada por 463 estudiantes de la Universidad de León. Se emplearon los siguientes instrumentos: Maslach Burnout Inventory-Student Survey (MBI-SS, 10-item Connor-Davidson Resilience Scale (10-item CD-RISC y Life Orientation Test Revised (LOT-R. Los resultados revelan que el burnout académico se relaciona significativamente con la resiliencia y el optimismo. Concretamente, la resiliencia se relaciona positivamente con la eficacia mientras que el optimismo se relaciona positivamente con la eficacia pero negativamente con el agotamiento. Además, la resiliencia predice la eficacia mientras que el optimismo predice el agotamiento. Sin embargo, el cinismo no se relaciona ni con la resiliencia ni con el optimismo. Por último, se contemplan las implicaciones de los resultados obtenidos para el diseño de programas de prevención del burnout académico en estudiantes universitarios.

  15. Multiconjugado académico para turismo: un programa en contexto

    Directory of Open Access Journals (Sweden)

    Carolina Delgado Hurtado

    2010-11-01

    Full Text Available El trabajo docente implica generar propuestas académicas integrales que involucren las actividades sustantivas de la Universidad pública con sus respectivas interacciones. El presente artículo intenta describir una propuesta académica que despliega lo que la autora ha denominado “El Multiconjugado Académico” compuesto por los tres (3 ejes fundamentales del quehacer universitario; la Docencia, entendida como el conjunto de actividades emprendidas para la comunicación y enseñanza de conocimientos, habilidades, ideas o experiencias; la Investigación, como proceso formal y sistemático para el descubrimiento y desarrollo de un cuerpo de conocimientos universales, y la Proyección social como la respuesta consciente y organizada a las problemáticas sociales no atendidas. La dinámica del presente artículo plantea que las tres funciones no se desarrollan ni se conciben como partes aisladas dentro del quehacer universitario; por el contrario, defiende la premisa de que constituyen un sistema integrado de actividades que se conjugan para el logro de los objetivos universitarios.

  16. Cholecystokinin A receptor (CCKAR gene variation is associated with language lateralization.

    Directory of Open Access Journals (Sweden)

    Sebastian Ocklenburg

    Full Text Available Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood. Therefore, the present study was aimed at investigating whether variation in schizophrenia-related genes modulates individual lateralization patterns. To this end, we genotyped 16 single nucleotide polymorphisms that have previously been linked to schizophrenia on a meta-analysis level in a sample of 444 genetically unrelated healthy participants and examined the association of these polymorphisms with handedness, footedness and language lateralization. We found a significant association of the cholecystokinin-A receptor (CCKAR gene variation rs1800857 and language lateralization assessed using the dichotic listening task. Individuals carrying the schizophrenia risk allele C of this polymorphism showed a marked reduction of the typical left-hemispheric dominance for language processing. Since the cholecystokinin A receptor is involved in dopamine release in the central nervous system, these findings suggest that genetic variation in this receptor may modulate language lateralization due to its impact on dopaminergic pathways.

  17. Genomic variation and its impact on gene expression in Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Andreas Massouras

    Full Text Available Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model organism populations are required. Here, we present a nucleotide resolution catalog of single-nucleotide, multi-nucleotide, and structural variants in 39 Drosophila melanogaster Genetic Reference Panel inbred lines. Using an integrative, local assembly-based approach for variant discovery, we identify more than 3.6 million distinct variants, among which were more than 800,000 unique insertions, deletions (indels, and complex variants (1 to 6,000 bp. While the SNP density is higher near other variants, we find that variants themselves are not mutagenic, nor are regions with high variant density particularly mutation-prone. Rather, our data suggest that the elevated SNP density around variants is mainly due to population-level processes. We also provide insights into the regulatory architecture of gene expression variation in adult flies by mapping cis-expression quantitative trait loci (cis-eQTLs for more than 2,000 genes. Indels comprise around 10% of all cis-eQTLs and show larger effects than SNP cis-eQTLs. In addition, we identified two-fold more gene associations in males as compared to females and found that most cis-eQTLs are sex-specific, revealing a partial decoupling of the genomic architecture between the sexes as well as the importance of genetic factors in mediating sex-biased gene expression. Finally, we performed RNA-seq-based allelic expression imbalance analyses in the offspring of crosses between sequenced lines, which revealed that the majority of strong cis-eQTLs can be validated in heterozygous individuals.

  18. Huntingtin gene repeat size variations affect risk of lifetime depression

    DEFF Research Database (Denmark)

    Gardiner, Sarah L.; van Belzen, Martine J.; Boogaard, Merel W.

    2017-01-01

    Huntington disease (HD) is a severe neuropsychiatric disorder caused by a cytosine-adenine-guanine (CAG) repeat expansion in the HTT gene. Although HD is frequently complicated by depression, it is still unknown to what extent common HTT CAG repeat size variations in the normal range could affect...

  19. The association of environmental, individual factors, and dopamine pathway gene variation with smoking cessation.

    Science.gov (United States)

    Li, Suyun; Wang, Qiang; Pan, Lulu; Yang, Xiaorong; Li, Huijie; Jiang, Fan; Zhang, Nan; Han, Mingkui; Jia, Chongqi

    2017-09-01

    This study aimed to examine whether dopamine (DA) pathway gene variation were associated with smoking cessation, and compare the relative importance of infulence factors on smoking cessation. Participants were recruited from 17 villages of Shandong Province, China. Twenty-five single nucleotide polymorphisms in 8 DA pathway genes were genotyped. Weighted gene score of each gene was used to analyze the whole gene effect. Logistic regression was used to calculate odds ratios (OR) of the total gene score for smoking cessation. Dominance analysis was employed to compare the relative importance of individual, heaviness of smoking, psychological and genetic factors on smoking cessation. 415 successful spontaneous smoking quitters served as the cases, and 404 unsuccessful quitters served as the controls. A significant negative association of total DA pathway gene score and smoking cessation was observed (p smoking cessation was heaviness of smoking score (42%), following by individual (40%), genetic (10%) and psychological score (8%). In conclusion, although the DA pathway gene variation was significantly associated with successful smoking cessation, heaviness of smoking and individual factors had bigger effect than genetic factors on smoking cessation.

  20. Deserción universitaria y alfabetización académica

    OpenAIRE

    Giohanny Olave-Arias; llene Rojas-García; Mireya Cisneros-Estupiñán

    2013-01-01

    El artículo pone en relación la deserción universitaria con la alfabetización académica, entendida como el nivel de desarrollo de la lectura y la escritura. El desarrollo del artículo consta de tres momentos: contextualización del problema de la deserción universitaria en Colombia; prácticas de lectura y escritura que generan dificultades de aprendizaje; importancia de la alfabetización académica para mejorar las habilidades lectoras de los estudiantes.

  1. Variations in CCL3L gene cluster sequence and non-specific gene copy numbers

    Directory of Open Access Journals (Sweden)

    Edberg Jeffrey C

    2010-03-01

    Full Text Available Abstract Background Copy number variations (CNVs of the gene CC chemokine ligand 3-like1 (CCL3L1 have been implicated in HIV-1 susceptibility, but the association has been inconsistent. CCL3L1 shares homology with a cluster of genes localized to chromosome 17q12, namely CCL3, CCL3L2, and, CCL3L3. These genes are involved in host defense and inflammatory processes. Several CNV assays have been developed for the CCL3L1 gene. Findings Through pairwise and multiple alignments of these genes, we have shown that the homology between these genes ranges from 50% to 99% in complete gene sequences and from 70-100% in the exonic regions, with CCL3L1 and CCL3L3 being identical. By use of MEGA 4 and BioEdit, we aligned sense primers, anti-sense primers, and probes used in several previously described assays against pre-multiple alignments of all four chemokine genes. Each set of probes and primers aligned and matched with overlapping sequences in at least two of the four genes, indicating that previously utilized RT-PCR based CNV assays are not specific for only CCL3L1. The four available assays measured median copies of 2 and 3-4 in European and African American, respectively. The concordance between the assays ranged from 0.44-0.83 suggesting individual discordant calls and inconsistencies with the assays from the expected gene coverage from the known sequence. Conclusions This indicates that some of the inconsistencies in the association studies could be due to assays that provide heterogenous results. Sequence information to determine CNV of the three genes separately would allow to test whether their association with the pathogenesis of a human disease or phenotype is affected by an individual gene or by a combination of these genes.

  2. Estimating variation within the genes and inferring the phylogeny of 186 sequenced diverse Escherichia coli genomes

    DEFF Research Database (Denmark)

    Kaas, Rolf Sommer; Rundsten, Carsten Friis; Ussery, David

    2012-01-01

    Background Escherichia coli exists in commensal and pathogenic forms. By measuring the variation of individual genes across more than a hundred sequenced genomes, gene variation can be studied in detail, including the number of mutations found for any given gene. This knowledge will be useful...... for creating better phylogenies, for determination of molecular clocks and for improved typing techniques. Results We find 3,051 gene clusters/families present in at least 95% of the genomes and 1,702 gene clusters present in 100% of the genomes. The former 'soft core' of about 3,000 gene families is perhaps...... more biologically relevant, especially considering that many of these genome sequences are draft quality. The E. coli pan-genome for this set of isolates contains 16,373 gene clusters. A core-gene tree, based on alignment and a pan-genome tree based on gene presence/absence, maps the relatedness...

  3. Understanding gene sequence variation in the context of transcription regulation in yeast.

    Directory of Open Access Journals (Sweden)

    Irit Gat-Viks

    2010-01-01

    Full Text Available DNA sequence polymorphism in a regulatory protein can have a widespread transcriptional effect. Here we present a computational approach for analyzing modules of genes with a common regulation that are affected by specific DNA polymorphisms. We identify such regulatory-linkage modules by integrating genotypic and expression data for individuals in a segregating population with complementary expression data of strains mutated in a variety of regulatory proteins. Our procedure searches simultaneously for groups of co-expressed genes, for their common underlying linkage interval, and for their shared regulatory proteins. We applied the method to a cross between laboratory and wild strains of S. cerevisiae, demonstrating its ability to correctly suggest modules and to outperform extant approaches. Our results suggest that middle sporulation genes are under the control of polymorphism in the sporulation-specific tertiary complex Sum1p/Rfm1p/Hst1p. In another example, our analysis reveals novel inter-relations between Swi3 and two mitochondrial inner membrane proteins underlying variation in a module of aerobic cellular respiration genes. Overall, our findings demonstrate that this approach provides a useful framework for the systematic mapping of quantitative trait loci and their role in gene expression variation.

  4. Sequence variation in TgROP7 gene among Toxoplasma gondii ...

    African Journals Online (AJOL)

    Yomi

    2012-03-27

    Mar 27, 2012 ... Toxoplasma gondii can infect a wide range of hosts including mammals and birds, causing toxoplasmosis which is one of the most common parasitic zoonoses worldwide. The present study examined sequence variation in rhoptry 7 (ROP7) gene among different T. gondii isolates from different hosts and ...

  5. Letramentos acadêmicos e multimodalidade em contexto de EaD semipresencial

    OpenAIRE

    Komesu, Fabiana

    2012-01-01

    De uma perspectiva teórica enunciativo-discursiva, este artigo tem como objetivo discutir o processo de constituição do texto em contexto digital, de maneira particularizada, por meio da problematização de modos e recursos semióticos atualizados na produção acadêmica do universitário que utiliza computador com acesso à internet no processo de Educação a Distância (EaD) semipresencial. Interessa investigar como o modelo de letramentos acadêmicos pode ser articulado ao estudo da multimodalidade...

  6. Deserción universitaria y alfabetización académica

    Directory of Open Access Journals (Sweden)

    Giohanny Olave-Arias

    2013-12-01

    Full Text Available El artículo pone en relación la deserción universitaria con la alfabetización académica, entendida como el nivel de desarrollo de la lectura y la escritura. El desarrollo del artículo consta de tres momentos: contextualización del problema de la deserción universitaria en Colombia; prácticas de lectura y escritura que generan dificultades de aprendizaje; importancia de la alfabetización académica para mejorar las habilidades lectoras de los estudiantes.

  7. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)

    DEFF Research Database (Denmark)

    Jim, Heather S L; Lin, Hui-Yi; Tyrer, Jonathan P

    2016-01-01

    Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadian genes are highly expressed in the ovari...

  8. Estrés académico y su relación con el rendimiento académico en estudiantes de la modalidad de estudios a distancia de la Universidad Católica los Ángeles de Chimbote sede Lima 2013

    OpenAIRE

    Buendia Torres, Alcidez

    2015-01-01

    El presente trabajo de investigación centró su atención en el estrés académico de los estudiantes universitarios en un contexto académico de estudios en la modalidad a distancia. El principal objetivo fue determinar la existencia o no de una correlación entre el estrés académico y el rendimiento académico, estas asociaciones fueron a su vez analizadas a nivel de intensidad del estrés, factores estresores, reacciones o síntomas y estrategias de afrontamiento del estrés. Las h...

  9. Evolución de los Cuerpos Académicos en la Universidad de Guanajuato Evolución de los Cuerpos Académicos en la Universidad de Guanajuato

    Directory of Open Access Journals (Sweden)

    Salma Evelia Preciado Tarabay

    2012-02-01

    Full Text Available The members of the Academic Community have slowly placed themselves in the local and national scene. They work towards a universal educational goal. This requires the renewal of systems and strategies to create knowledge adaptable to the dynamic changes of a globalized world. The quality of higher education depends on many factors, one of the most important, is the professor; as such, the Academic Community takes seriously the professor’s tenure track as well as the overall education. This education implies a deep conceptual understanding of taught academic disciplines, this ideally is demonstrated by the completion of a PhD degree. This is why the University of Guanajuato has placed emphasis on the conformation of Academic Communities. Furthermore, permanent support to the faculty is offered to study graduate degrees with the idea of creating and applying new knowledge and offering them the installations that wil allow them to fulfill their academic functions. The perseverance of the work of the Academic Communities has contributed to their consolidaton in such a way that in 2002 there were only five Academic Communities and now a day there are 14.Los Cuerpos académicos han transitado paulatinamente hacia su posicionamiento en el ámbito estatal y nacional. Avanzan hacia una universalidad que requiere renovar esquemas y ampliar estrategias que se dirijan hacia la generación del conocimiento asumiendo un papel protagónico para insertarse en la dinámica del cambio en un mundo globalizado. La calidad de la educación superior está en función de múltiples factores, pero entre éstos el más importante es el profesor de carrera; es por ello que los Cuerpos Académicos contemplan un profesorado con formación completa que los capacite y habilite para el conjunto de las funciones académicas que les compete. Esta formación implica profundizar sus conocimientos en un nivel superior al que impartan, idealmente la formación completa es el

  10. Ausentismo, presentismo y rendimiento académico en estudiantes de universidades peruanas

    OpenAIRE

    Chafloque Céspedes, Raquel; Vara-Horna, Arístides; Lopez-Odar, Dennis; Santi-Huaranca, Inés; Diaz-Rosillo, Alberto; Asencios-Gonzalez, Zaida

    2017-01-01

    El objetivo de la presente investigación fue determinar el efecto del ausentismo y presentismo sobre el rendimiento académico en los estudiantes de pregrado de las Escuelas de Negocios e Ingenierías en las Universidades Peruanas. El estudio se sustenta en una encuesta de autoreporte a 8,203 estudiantes de las escuelas de negocios e ingenierías de las universidades peruanas. Se emplearon escalas para analizar el ausentismo, presentismo y rendimiento académico que mostraron adecuadas propiedade...

  11. Uma Reflexão sobre Autoria Acadêmica

    Directory of Open Access Journals (Sweden)

    Francisco José da Costa

    2017-06-01

    Full Text Available Este estudo tem como objetivo apresentar elementos para um debate sobre a ética das práticas de autoria no campo científico brasileiro. Os autores utilizam exemplos ilustrativos para explorar as práticas de pseudoautoria, estabelecendo relações entre essas práticas, as coerções oriundas do campo acadêmico e o habitus dos agentes sociais. Foi elaborada uma definição preliminar do que seja autoria a fim de possibilitar a discussão sobre dois problemas centrais, que são: a lógica de “colocar o nome” e o plágio. Uma das principais contribuições deste trabalho repousa na reflexão orientada para a construção de uma prática aperfeiçoada de autoria, possibilitando a crítica e a autocrítica dos agentes do meio acadêmico sobre algumas práticas problemáticas de autoria.

  12. Expression profiles of variation integration genes in bladder urothelial carcinoma.

    Science.gov (United States)

    Wang, J M; Wang, Y Q; Gao, Z L; Wu, J T; Shi, B K; Yu, C C

    2014-04-30

    Bladder cancer is a common cancer worldwide and its incidence continues to increase. There are approximately 261,000 cases of bladder cancer resulting in 115,000 deaths annually. This study aimed to integrate bladder cancer genome copy number variation information and bladder cancer gene transcription level expression data to construct a causal-target module network of the range of bladder cancer-related genomes. Here, we explored the control mechanism underlying bladder cancer phenotype expression regulation by the major bladder cancer genes. We selected 22 modules as the initial module network to expand the search to screen more networks. After bootstrapping 100 times, we obtained 16 key regulators. These 16 key candidate regulatory genes were further expanded to identify the expression changes of 11,676 genes in 275 modules, which may all have the same regulation. In conclusion, a series of modules associated with the terms 'cancer' or 'bladder' were considered to constitute a potential network.

  13. Vida académica de la facultad

    OpenAIRE

    Facultad de Medicina Revista

    1999-01-01

    Enciclopedia Académica sobre el Lenguaje en las Ciencias de la Salud / Convenio con la Universidad de Alcalá de Henares / Libro de Biología / XI Congreso de actualización en Rehabilitación Médica. Dolor crónico, diagnóstico y manejo integral / Primer Congreso Latinoamericano de Estudiantes de Nutrición y Dietética

  14. Autorregulación y rendimiento académico en la transición secundaria–universidad

    Directory of Open Access Journals (Sweden)

    María Antonieta Elvira-Valdés

    2012-05-01

    Full Text Available El objetivo del presente estudio consistió en identificar los niveles deautorregulación académica y su relación con el rendimiento académico y determinadas variablessociodemográficas en estudiantes universitarios. En esta investigación no experimental de campoparticiparon 172 estudiantes del Ciclo de Iniciación Universitaria de la Universidad Simón Bolívar.La autorregulación se midió mediante la Escala de Aprendizaje Autorregulado PCR (Lezama, 2005.Los resultados obtenidos sugieren niveles moderados de autorregulación en el aprendizaje, así comoligeras diferencias en cuanto al género, tipo de institución y ligera significancia entre reflexiónautorregulatoria y rendimiento académico. Así mismo, las correlaciones positivas encontradas entrepuntaje de ingreso e índice académico final, sugieren la asociación del rendimiento previo en el éxitoacadémico en función de las notas.

  15. Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.

    Science.gov (United States)

    Zhang, J R; Norris, S J

    1998-08-01

    The Lyme disease spirochete Borrelia burgdorferi possesses 15 silent vls cassettes and a vls expression site (vlsE) encoding a surface-exposed lipoprotein. Segments of the silent vls cassettes have been shown to recombine with the vlsE cassette region in the mammalian host, resulting in combinatorial antigenic variation. Despite promiscuous recombination within the vlsE cassette region, the 5' and 3' coding sequences of vlsE that flank the cassette region are not subject to sequence variation during these recombination events. The segments of the silent vls cassettes recombine in the vlsE cassette region through a unidirectional process such that the sequence and organization of the silent vls loci are not affected. As a result of recombination, the previously expressed segments are replaced by incoming segments and apparently degraded. These results provide evidence for a gene conversion mechanism in VlsE antigenic variation.

  16. Novel sequence variations in LAMA2 and SGCG genes modulating cis-acting regulatory elements and RNA secondary structure

    Directory of Open Access Journals (Sweden)

    Olfa Siala

    2010-01-01

    Full Text Available In this study, we detected new sequence variations in LAMA2 and SGCG genes in 5 ethnic populations, and analysed their effect on enhancer composition and mRNA structure. PCR amplification and DNA sequencing were performed and followed by bioinformatics analyses using ESEfinder as well as MFOLD software. We found 3 novel sequence variations in the LAMA2 (c.3174+22_23insAT and c.6085 +12delA and SGCG (c.*102A/C genes. These variations were present in 210 tested healthy controls from Tunisian, Moroccan, Algerian, Lebanese and French populations suggesting that they represent novel polymorphisms within LAMA2 and SGCG genes sequences. ESEfinder showed that the c.*102A/C substitution created a new exon splicing enhancer in the 3'UTR of SGCG genes, whereas the c.6085 +12delA deletion was situated in the base pairing region between LAMA2 mRNA and the U1snRNA spliceosomal components. The RNA structure analyses showed that both variations modulated RNA secondary structure. Our results are suggestive of correlations between mRNA folding and the recruitment of spliceosomal components mediating splicing, including SR proteins. The contribution of common sequence variations to mRNA structural and functional diversity will contribute to a better study of gene expression.

  17. Oxytocin receptor gene variation predicts subjective responses to MDMA.

    Science.gov (United States)

    Bershad, Anya K; Weafer, Jessica J; Kirkpatrick, Matthew G; Wardle, Margaret C; Miller, Melissa A; de Wit, Harriet

    2016-12-01

    3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") enhances desire to socialize and feelings of empathy, which are thought to be related to increased oxytocin levels. Thus, variation in the oxytocin receptor gene (OXTR) may influence responses to the drug. Here, we examined the influence of a single OXTR nucleotide polymorphism (SNP) on responses to MDMA in humans. Based on findings that carriers of the A allele at rs53576 exhibit reduced sensitivity to oxytocin-induced social behavior, we hypothesized that these individuals would show reduced subjective responses to MDMA, including sociability. In this three-session, double blind, within-subjects study, healthy volunteers with past MDMA experience (N = 68) received a MDMA (0, 0.75 mg/kg, and 1.5 mg/kg) and provided self-report ratings of sociability, anxiety, and drug effects. These responses were examined in relation to rs53576. MDMA (1.5 mg/kg) did not increase sociability in individuals with the A/A genotype as it did in G allele carriers. The genotypic groups did not differ in responses at the lower MDMA dose, or in cardiovascular or other subjective responses. These findings are consistent with the idea that MDMA-induced sociability is mediated by oxytocin, and that variation in the oxytocin receptor gene may influence responses to the drug.

  18. Rendimiento académico y calidad de vida relacionada con la salud en estudiantes de odontología

    Directory of Open Access Journals (Sweden)

    Shyrley Díaz Cárdenas

    2017-01-01

    Full Text Available Objetivo:Asociar rendimiento académico y la calidad de vida relacionada con la salud (CVRSen estudiantes de odontología de la Universidad de Cartagena.Materiales y métodos:Estudio de corte transversal realizado en 347 estudiantes, previoconsentimiento informado. Se diseñó y aplicó encuesta autodiligenciada para indagar variablessociodemográficas yCVRS(WHOQOL-BREF. El rendimiento académico fue obtenido a través dela Secretaría Académica de la institución. Se estimaron ocurrencias (prevalencias y asociacionesentre variables (odds ratios con un nivel de confianza del 95 %Resultados:35,2 % de los estudiantes presentaron bajo rendimiento académico, y los prin-cipales motivos de pérdidas de asignaturas fueron poco tiempo dedicado a estudiar (20,1 % ymetodología académica utilizada (13,8 %. Según el cuestionarioWHOQOL-BREF, 37,7% de losestudiantes percibió que presenta una buenaCVRSy sentirse bastante bien con su salud (52,2%. Se encontró asociación entre los estudiantes con bajo rendimiento académico y compromisodel dominio social evaluado por elWHOQOL-BREEF(OR=2,13,IC95 %=1,12-4,06 p=0,02 yser adolescente (OR=1,7,IC95 %=1,04-3,05 p=0,03.Conclusión:Se halló asociación entre bajo rendimiento académico y compromiso con el dominiosocial de los estudiantes en relación con laCVRSy ser adolescente. El contexto universitario debemirar de una manera holística el desarrollo académico del estudiante en aras del mejoramientode su calidad de vida.

  19. MAINTENANCE OF ECOLOGICALLY SIGNIFICANT GENETIC VARIATION IN THE TIGER SWALLOWTAIL BUTTERFLY THROUGH DIFFERENTIAL SELECTION AND GENE FLOW.

    Science.gov (United States)

    Bossart, J L; Scriber, J M

    1995-12-01

    Differential selection in a heterogeneous environment is thought to promote the maintenance of ecologically significant genetic variation. Variation is maintained when selection is counterbalanced by the homogenizing effects of gene flow and random mating. In this study, we examine the relative importance of differential selection and gene flow in maintaining genetic variation in Papilio glaucus. Differential selection on traits contributing to successful use of host plants (oviposition preference and larval performance) was assessed by comparing the responses of southern Ohio, north central Georgia, and southern Florida populations of P. glaucus to three hosts: Liriodendron tulipifera, Magnolia virginiana, and Prunus serotina. Gene flow among populations was estimated using allozyme frequencies from nine polymorphic loci. Significant genetic differentiation was observed among populations for both oviposition preference and larval performance. This differentiation was interpreted to be the result of selection acting on Florida P. glaucus for enhanced use of Magnolia, the prevalent host in Florida. In contrast, no evidence of population differentiation was revealed by allozyme frequencies. F ST -values were very small and Nm, an estimate of the relative strengths of gene flow and genetic drift, was large, indicating that genetic exchange among P. glaucus populations is relatively unrestricted. The contrasting patterns of spatial differentiation for host-use traits and lack of differentiation for electrophoretically detectable variation implies that differential selection among populations will be counterbalanced by gene flow, thereby maintaining genetic variation for host-use traits. © 1995 The Society for the Study of Evolution.

  20. Facing the facts: The Runx2 gene is associated with variation in facial morphology in primates.

    Science.gov (United States)

    Ritzman, Terrence B; Banovich, Nicholas; Buss, Kaitlin P; Guida, Jennifer; Rubel, Meagan A; Pinney, Jennifer; Khang, Bao; Ravosa, Matthew J; Stone, Anne C

    2017-10-01

    The phylogenetic and adaptive factors that cause variation in primate facial form-including differences among the major primate clades and variation related to feeding and/or social behavior-are relatively well understood. However, comparatively little is known about the genetic mechanisms that underlie diversity in facial form in primates. Because it is essential for osteoblastic differentiation and skeletal development, the runt-related transcription factor 2 (Runx2) is one gene that may play a role in these genetic mechanisms. Specifically, polymorphisms in the QA ratio (determined by the ratio of the number of polyglutamines to polyalanines in one functional domain of Runx2) have been shown to be correlated with variation in facial length and orientation in other mammal groups. However, to date, the relationship between variation in this gene and variation in facial form in primates has not been explicitly tested. To test the hypothesis that the QA ratio is correlated with facial form in primates, the current study quantified the QA ratio, facial length, and facial angle in a sample of 33 primate species and tested for correlation using phylogenetic generalized least squares. The results indicate that the QA ratio of the Runx2 gene is positively correlated with variation in relative facial length in anthropoid primates. However, no correlation was found in strepsirrhines, and there was no correlation between facial angle and the QA ratio in any groups. These results suggest that, in primates, the QA ratio of the Runx2 gene may play a role in modulating facial size, but not facial orientation. This study therefore provides important clues about the genetic and developmental mechanisms that may underlie variation in facial form in primates. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Vida académica de la facultad

    Directory of Open Access Journals (Sweden)

    Facultad de Medicina Revista

    1999-07-01

    Full Text Available Enciclopedia Académica sobre el Lenguaje en las Ciencias de la Salud / Convenio con la Universidad de Alcalá de Henares / Libro de Biología / XI Congreso de actualización en Rehabilitación Médica. Dolor crónico, diagnóstico y manejo integral / Primer Congreso Latinoamericano de Estudiantes de Nutrición y Dietética

  2. ¿Oferta o renovación académica?

    OpenAIRE

    Serani Prádenas, Edmundo

    2017-01-01

    Aunque sin divulgar una definición, lo que es altamente preocupante, las autoridades universitarias han legitimado el término "Renovación de la Oferta Académica", el que en nuestra opinión tiene importantes limitaciones.

  3. Os estudos acadêmicos de literatura: uma experiência constitutiva

    Directory of Open Access Journals (Sweden)

    Eunice T. Piazza Gai

    2015-07-01

    Full Text Available O artigo apresenta uma reflexão sobre o tema dos estudos acadêmicos de literatura. Embasa-se na leitura de diversos autores, tais como Platão, Vygotsky, Compagnon, Palmer, Bruner, Secchieri, entre outros. Defende a ideia de que é necessário rever as práticas acadêmicas que consideram os textos literários de um ponto de vista exógeno. Em contrapartida, seria preferível que os estudos de literatura se voltassem para as questões da sua natureza intrínseca, ou seja, que ocorressem, a partir da reflexão sobre a especificidade do conhecimento por ela veiculado e sobre as possibilidades de constituição de sentido propiciadas pelo trabalho hermenêutico.

  4. Programa de Acompañamiento para Estudiantes en Riesgo Académico

    OpenAIRE

    Chinchilla-Brenes, Sonia

    2006-01-01

    Informe El Programa de Acompañamiento para estudiantes en Riesgo Académico lo generó el Departamento de Orientación y Psicología del ITCR con el objetivo de atender mediante diversas acciones de acompañamiento y asesoría psicoeducativa a estudiantes de primer ingreso que, por sus características psicoeducativas y socioeconómicas, muestren más probabilidades de obtener bajo rendimiento académico o altas tasas de deserción. Se espera con ello favorecer el ajuste a la universidad, la permanen...

  5. Genetic variations of MMP9 gene and intracerebral hemorrhage susceptibility: a case-control study in Chinese Han population.

    Science.gov (United States)

    Yang, Jie; Wu, Bo; Lin, Sen; Zhou, Junshan; Li, Yingbin; Dong, Wei; Arima, Hisatomi; Zhang, Chanfei; Liu, Yukai; Liu, Ming

    2014-06-15

    To investigate the association between genetic variations of matrix metalloproteinase 9 (MMP9) gene and intracerebral hemorrhage (ICH) susceptibility in Chinese Han population. The clinical data and peripheral blood samples from the patients with ICH and hypertension, and controlled subjects with hypertension only, were collected. MassARRAY Analyzer was used to genotype the tagger single nucleotide polymorphism (SNP) of MMP9 gene. Haploview4.2 and Unphased3.1.7 were employed to construct haplotypes and to analyze the association between genetic variations (alleles, genotypes and haplotypes) of MMP9 gene and ICH susceptibility. 181 patients with ICH and hypertension, and 197 patients with hypertension only, were recruited between Sep 2009 and Oct 2010. Patients in the ICH group were younger (61.80 ± 13.27 vs. 72.44 ± 12.71 years, ppopulation. Our logistical regression analysis showed that there were no significant associations between genetic variations of the MPP9 gene and ICH susceptibility (all p>0.05). The genetic variations of MMP9 gene were not significantly associated with ICH susceptibility in the Chinese Han population. Copyright © 2014 Elsevier B.V. All rights reserved.

  6. Riesgo familiar total en familias con escolares según rendimiento académico

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    CAROLINA LUCERO ENRÍQUEZ GUERRERO

    2009-12-01

    Full Text Available Este artículo presenta los resultados del estudio cuyo objetivo fue establecer las diferencias en el riesgo familiar entre dos grupos de familias: con niños escolares de alto rendimiento y niños de bajo rendimiento académico en un centro educativo distrital de Bogotá. Metodología: estudio descriptivo comparativo transversal con un componente analítico y abordaje cuantitativo; la muestra fue de 186 familias, durante abril a julio de 2007. Los resultados muestran predominio de familias nucleares en ambos grupos (65%, relación inversa entre el riesgo familiar total evaluado por el instrumento RFT 7-70 y el rendimiento académico del escolar de la familia, es decir que las familias que registraron riesgo alto (9% y medio (31% en mayor proporción son familias con escolares de bajo rendimiento académico, frente al predominio del riesgo familiar bajo (78% en las familias con niños de alto rendimiento. Se aplicó t de student para diferencia de medias y se encontró asociación (P = 0,02 entre el riesgo familiar total alto y el bajo rendimiento académico del escolar. En conclusión, estos resultados sugieren principalmente que se deben priorizar los factores de riesgo que determinan mayor riesgo familiar en familias con escolares de bajo rendimiento académico y dar atención de salud integral con enfoque familiar e intersectorial, y participación activa de la comunidad. Continuar investigando en posibles asociaciones entre salud individual, prácticas de salud, educación, ambiente socioeconómico y psicoafectivo de la familia y el logro educativo de escolares en familias con niños en edad escolar.

  7. Inteligencia emocional y rendimiento académico en estudiantes universitarios

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    Martha Luz Páez Cala

    2015-01-01

    Full Text Available El estudio tuvo como objetivo describir la inteligencia emocional y determinar su relación con el rendimiento académico en estudiantes universitarios. Participaron 263 estudiantes, a quienes se les aplicaron diversos instrumentos, entre ellos el cuestionario EQ -i de Bar O n para medir la inteligencia emocional. Se encontró un cociente de inteligencia emocional promedio de 46,51, sin diferencias según género, pero sí para cada programa: 62,9 para Economía; 55,69 en Medicina; 54,28 en Psicología y 36,58 para Derecho. Se encontró correlación entre el valor de IE y nota promedio hasta el momento (p = .019, mayor para Medicina (p = .001, seguido de Psicología (p = .066; no se encontró relación en los otros programas. Se presenta un modelo de dependencia cúbica entre coeficiente de inteligencia emocional y rendimiento académico significativo para el total de la población de Medicina y Psicología. Así mismo se encontró dependencia significativa de este coeficiente con programa (p = .000 y semestre (p = .000, aunque esta última presenta tendencia clara solo para Medicina. Los resultados coinciden con los de otros estudios que encuentran correlación entre inteligencia emocional y rendimiento académico.

  8. Pedagogía y créditos académicos

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    MARTHA SOLEDAD MONTERO G.

    2006-01-01

    Full Text Available La reforma educativa, de los años noventa, diseña, monta, pone en marcha y ejecuta tres políticaspara la educación superior, con el objetivo de ampliar la cobertura educativa, a partir de estrategias,que tienen que ver con el acceso, el uso de nuevas metodologías y tecnologías, las MesasRegionales de Cobertura y el apoyo a la gestión de las instituciones de Educación Superior. De ahí,que, para señalar, los efectos que surgen de la implementación de los créditos académicos en launiversidad, este artículo: (i describe de manera esquemática la política de ampliación de lacobertura, con el propósito de situar la concepción de crédito académico en la política deeducación superior en Colombia (ii mostrar la función que cumplen los créditos académicos enel currículo (iii y por último, señalar la relación que, al parecer existe entre noción de créditoacadémico y sus implicaciones en las practicas pedagógicas dentro de la reforma educativa parala Educación Superior.

  9. género y rendimiento académico

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    Elberto Antonio Plazas

    2006-01-01

    Full Text Available Se pretendió establecer si existía un efecto de interacción entre el estatus sociométrico y el género sobre el rendimiento académico en una muestra de 156 estudiantes (88 niñas y 68 varones de educación secundaria de un reconocido colegio público de Valledupar (Colombia. El estatus sociométrico se evaluó según las nominaciones de los pares para categorizar a los estudiantes en seis grupos: popular, rechazado, excluido, controvertido, promedio y no clasificado. El análisis de varianza no reveló un efecto significativo de la interacción del estatus sociométrico y el género sobre el rendimiento académico, aunque sí mostró un efecto significativo independiente de las dos variables principales. En la prueba post hoc, se presentó una relación directa entre el rendimiento y la Preferencia Social, así como entre el rendimiento y el Impacto Social, y una diferencia significativa entre niñas y varones controvertidos.

  10. Random phenotypic variation of yeast (Saccharomyces cerevisiae) single-gene knockouts fits a double pareto-lognormal distribution.

    Science.gov (United States)

    Graham, John H; Robb, Daniel T; Poe, Amy R

    2012-01-01

    Distributed robustness is thought to influence the buffering of random phenotypic variation through the scale-free topology of gene regulatory, metabolic, and protein-protein interaction networks. If this hypothesis is true, then the phenotypic response to the perturbation of particular nodes in such a network should be proportional to the number of links those nodes make with neighboring nodes. This suggests a probability distribution approximating an inverse power-law of random phenotypic variation. Zero phenotypic variation, however, is impossible, because random molecular and cellular processes are essential to normal development. Consequently, a more realistic distribution should have a y-intercept close to zero in the lower tail, a mode greater than zero, and a long (fat) upper tail. The double Pareto-lognormal (DPLN) distribution is an ideal candidate distribution. It consists of a mixture of a lognormal body and upper and lower power-law tails. If our assumptions are true, the DPLN distribution should provide a better fit to random phenotypic variation in a large series of single-gene knockout lines than other skewed or symmetrical distributions. We fit a large published data set of single-gene knockout lines in Saccharomyces cerevisiae to seven different probability distributions: DPLN, right Pareto-lognormal (RPLN), left Pareto-lognormal (LPLN), normal, lognormal, exponential, and Pareto. The best model was judged by the Akaike Information Criterion (AIC). Phenotypic variation among gene knockouts in S. cerevisiae fits a double Pareto-lognormal (DPLN) distribution better than any of the alternative distributions, including the right Pareto-lognormal and lognormal distributions. A DPLN distribution is consistent with the hypothesis that developmental stability is mediated, in part, by distributed robustness, the resilience of gene regulatory, metabolic, and protein-protein interaction networks. Alternatively, multiplicative cell growth, and the mixing of

  11. High natural gene expression variation in the reef-building coral Acropora millepora: potential for acclimative and adaptive plasticity.

    Science.gov (United States)

    Granados-Cifuentes, Camila; Bellantuono, Anthony J; Ridgway, Tyrone; Hoegh-Guldberg, Ove; Rodriguez-Lanetty, Mauricio

    2013-04-08

    Ecosystems worldwide are suffering the consequences of anthropogenic impact. The diverse ecosystem of coral reefs, for example, are globally threatened by increases in sea surface temperatures due to global warming. Studies to date have focused on determining genetic diversity, the sequence variability of genes in a species, as a proxy to estimate and predict the potential adaptive response of coral populations to environmental changes linked to climate changes. However, the examination of natural gene expression variation has received less attention. This variation has been implicated as an important factor in evolutionary processes, upon which natural selection can act. We acclimatized coral nubbins from six colonies of the reef-building coral Acropora millepora to a common garden in Heron Island (Great Barrier Reef, GBR) for a period of four weeks to remove any site-specific environmental effects on the physiology of the coral nubbins. By using a cDNA microarray platform, we detected a high level of gene expression variation, with 17% (488) of the unigenes differentially expressed across coral nubbins of the six colonies (jsFDR-corrected, p natural variation between reef corals when assessing experimental gene expression differences. The high transcriptional variation detected in this study is interpreted and discussed within the context of adaptive potential and phenotypic plasticity of reef corals. Whether this variation will allow coral reefs to survive to current challenges remains unknown.

  12. Aperturas epistémicas y transformaciones intersubjetivas: haciendo acompañamiento académico a tesis de maestría

    OpenAIRE

    Munévar M., Dora Inés

    2012-01-01

    Antecedentes. Se retoman los orígenes individuales e interesados de los recorridos registrados por quienes hacen tesis de maestría. Objetivo. Repensar los nexos entre las formas de hacer investigación y acompañamiento académico a tesis de posgrado. Materiales y métodos. Remiten a los procesos investigativos de cuatro tesistas en tres maestrías de la Universidad Nacional de Colombia: discapacidad e inclusión social (2), estudios de género (1) y educación con énfasis en comunicación (1), recurr...

  13. Mejora en la motivación por la Lectura Académica: la mirada de estudiantes motivados

    Directory of Open Access Journals (Sweden)

    Carla Muñoz

    2016-01-01

    Full Text Available Dada la importancia de la lectura académica en la formación universitaria y que uno de los factores gravitantes en este tipo de tarea son los aspectos motivacionales, el presente trabajo tuvo como objetivo identificar los elementos, que según los propios protagonistas explicarían el incremento de su motivación por la lectura de textos académicos. El estudio de carácter mixto se realizó en dos fases. En una primera fase fueron identificados a partir de una muestra amplia (n=1205 estudiantes con alta motivación por la lectura académica y que hubiesen experimentado un cambio motivacional positivo (n=10. En una segunda fase, estos casos fueron sujetos de entrevistas en profundidad y el análisis de estas entrevistas se recogen en este artículo. Los resultados muestran como causas de la mejora de la motivación por la lectura académica, dinámicas vinculadas con el desafío, el ingreso a la lógica universitaria (desescolarización y las proyecciones académico/profesionales de estos estudiantes; procesos que se encuentran vinculados a los primeros años de formación, favorecidos por docentes que promueven una dinámica académica en la formación. Se discuten finalmente las implicaciones de estas dinámicas para la formación universitaria.

  14. [Genetic variation analysis of canine parvovirus VP2 gene in China].

    Science.gov (United States)

    Yi, Li; Cheng, Shi-Peng; Yan, Xi-Jun; Wang, Jian-Ke; Luo, Bin

    2009-11-01

    To recognize the molecular biology character, phylogenetic relationship and the state quo prevalent of Canine parvovirus (CPV), Faecal samnples from pet dogs with acute enteritis in the cities of Beijing, Wuhan, and Nanjing were collected and tested for CPV by PCR and other assay between 2006 and 2008. There was no CPV to FPV (MEV) variation by PCR-RFLP analysis in all samples. The complete ORFs of VP2 genes were obtained by PCR from 15 clinical CPVs and 2 CPV vaccine strains. All amplicons were cloned and sequenced. Analysis of the VP2 sequences showed that clinical CPVs both belong to CPV-2a subtype, and could be classified into a new cluster by amino acids contrasting which contains Tyr-->Ile (324) mutation. Besides the 2 CPV vaccine strains belong to CPV-2 subtype, and both of them have scattered variation in amino acids residues of VP2 protein. Construction of the phylogenetic tree based on CPV VP2 sequence showed these 15 CPV clinical strains were in close relationship with Korea strain K001 than CPV-2a isolates in other countries at early time, It is indicated that the canine parvovirus genetic variation was associated with location and time in some degree. The survey of CPV capsid protein VP2 gene provided the useful information for the identification of CPV types and understanding of their genetic relationship.

  15. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    OpenAIRE

    Chornokur, Ganna; Lin, Hui-Yi; Tyrer, Jonathan P.; Lawrenson, Kate; Dennis, Joe; Amankwah, Ernest K.; Qu, Xiaotao; Tsai, Ya-Yu; Jim, Heather S. L.; Chen, Zhihua; Chen, Ann Y.; Permuth-Wey, Jennifer; Aben, Katja KH.; Anton-Culver, Hoda; Antonenkova, Natalia

    2015-01-01

    Background\\ud \\ud Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contribu...

  16. Percepções Acadêmicas sobre o Ensino e a Aprendizagem em Anatomia Humana

    Directory of Open Access Journals (Sweden)

    Cléton Salbego

    Full Text Available Esta pesquisa investiga as percepções de acadêmicos sobre o processo de ensino e aprendizagem na disciplina de Anatomia Humana oferecida nos cursos de Ciências Biológicas e Enfermagem de uma universidade da Região Centro-Oeste do Estado do Rio Grande do Sul. Trata-se de uma pesquisa qualitativa, com caráter descritivo e exploratório, realizada com dez acadêmicos de cada um dos cursos envolvidos, regularmente matriculados na disciplina e frequentando o Laboratório de Anatomia Humana. Os depoimentos foram coletados por meio de entrevistas semiestruturadas e analisados à luz da análise de conteúdo. Emergiram percepções acerca do processo de ensino e aprendizagem da disciplina e da sua relevância para a formação profissional. Conclui-se que as percepções dos acadêmicos apontam obstáculos enfrentados para uma aprendizagem efetiva. As dificuldades despertam nos estudantes sentimentos de impotência e desânimo. Nesse contexto, surge um grande desafio: propor estudos que considerem a opinião dos acadêmicos, promovendo espaços de troca e construção coletiva do processo de formação.

  17. Hacia una didáctica de la escritura académica en la universidad

    Directory of Open Access Journals (Sweden)

    Victoria Yolanda Villaseñor López

    2013-01-01

    Full Text Available La lectura y escritura académicas en la universidad escasamente han sido atendidas como materia y contenido de enseñanza por los profesores. Se asume tácitamente que los alumnos han adquirido, durante su formación en los niveles y grados escolares previos, las competencias suficientes para desempeñarse como lectores y escritores especializados en las temáticas del estudio disciplinario. Sin embargo, los escritos de los estudiantes muestran un panorama poco optimista respecto a las competencias que han adquirido y desarrollado. Ante esta necesidad, y a partir de algunas dificultades específicas de escritura identificadas en las versiones de un capítulo de tesis de estudiantes del 8o semestre de la Licenciatura en Educación de Adultos (UPN, se emprendió una intervención didáctica para orientar la escritura académica. Tales fueron los objetivos de investigación e intervención que se atendieron y de los cuales trataremos en el presente artículo. Al final, descubrimos que la escritura académica guiada puede dar lugar a versiones del desempeño académico y sus expresiones disciplinarias cada vez más logradas y exitosas.

  18. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).

    Science.gov (United States)

    Jim, Heather S L; Lin, Hui-Yi; Tyrer, Jonathan P; Lawrenson, Kate; Dennis, Joe; Chornokur, Ganna; Chen, Zhihua; Chen, Ann Y; Permuth-Wey, Jennifer; Aben, Katja Kh; Anton-Culver, Hoda; Antonenkova, Natalia; Bruinsma, Fiona; Bandera, Elisa V; Bean, Yukie T; Beckmann, Matthias W; Bisogna, Maria; Bjorge, Line; Bogdanova, Natalia; Brinton, Louise A; Brooks-Wilson, Angela; Bunker, Clareann H; Butzow, Ralf; Campbell, Ian G; Carty, Karen; Chang-Claude, Jenny; Cook, Linda S; Cramer, Daniel W; Cunningham, Julie M; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; du Bois, Andreas; Despierre, Evelyn; Sieh, Weiva; Doherty, Jennifer A; Dörk, Thilo; Dürst, Matthias; Easton, Douglas F; Eccles, Diana M; Edwards, Robert P; Ekici, Arif B; Fasching, Peter A; Fridley, Brooke L; Gao, Yu-Tang; Gentry-Maharaj, Aleksandra; Giles, Graham G; Glasspool, Rosalind; Goodman, Marc T; Gronwald, Jacek; Harter, Philipp; Hasmad, Hanis N; Hein, Alexander; Heitz, Florian; Hildebrandt, Michelle A T; Hillemanns, Peter; Hogdall, Claus K; Hogdall, Estrid; Hosono, Satoyo; Iversen, Edwin S; Jakubowska, Anna; Jensen, Allan; Ji, Bu-Tian; Karlan, Beth Y; Kellar, Melissa; Kiemeney, Lambertus A; Krakstad, Camilla; Kjaer, Susanne K; Kupryjanczyk, Jolanta; Vierkant, Robert A; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D; Lee, Alice W; Lele, Shashi; Leminen, Arto; Lester, Jenny; Levine, Douglas A; Liang, Dong; Lim, Boon Kiong; Lissowska, Jolanta; Lu, Karen; Lubinski, Jan; Lundvall, Lene; Massuger, Leon F A G; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R; McNeish, Ian; Menon, Usha; Milne, Roger L; Modugno, Francesmary; Thomsen, Lotte; Moysich, Kirsten B; Ness, Roberta B; Nevanlinna, Heli; Eilber, Ursula; Odunsi, Kunle; Olson, Sara H; Orlow, Irene; Orsulic, Sandra; Palmieri Weber, Rachel; Paul, James; Pearce, Celeste L; Pejovic, Tanja; Pelttari, Liisa M; Pike, Malcolm C; Poole, Elizabeth M; Schernhammer, Eva; Risch, Harvey A; Rosen, Barry; Rossing, Mary Anne; Rothstein, Joseph H; Rudolph, Anja; Runnebaum, Ingo B; Rzepecka, Iwona K; Salvesen, Helga B; Schwaab, Ira; Shu, Xiao-Ou; Shvetsov, Yurii B; Siddiqui, Nadeem; Song, Honglin; Southey, Melissa C; Spiewankiewicz, Beata; Sucheston-Campbell, Lara; Teo, Soo-Hwang; Terry, Kathryn L; Thompson, Pamela J; Tangen, Ingvild L; Tworoger, Shelley S; van Altena, Anne M; Vergote, Ignace; Walsh, Christine S; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S; Wicklund, Kristine G; Wilkens, Lynne R; Wu, Anna H; Wu, Xifeng; Woo, Yin-Ling; Yang, Hannah; Zheng, Wei; Ziogas, Argyrios; Amankwah, Ernest; Berchuck, Andrew; Schildkraut, Joellen M; Kelemen, Linda E; Ramus, Susan J; Monteiro, Alvaro N A; Goode, Ellen L; Narod, Steven A; Gayther, Simon A; Pharoah, Paul D P; Sellers, Thomas A; Phelan, Catherine M

    Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadian genes are highly expressed in the ovaries where they regulate ovulation; circadian disruption is associated with several ovarian cancer risk factors (e.g., endometriosis). However, no studies have examined variation in germline circadian genes as predictors of ovarian cancer risk and invasiveness. The goal of the current study was to examine single nucleotide polymorphisms (SNPs) in circadian genes BMAL1, CRY2, CSNK1E, NPAS2, PER3, REV1 and TIMELESS and downstream transcription factors KLF10 and SENP3 as predictors of risk of epithelial ovarian cancer (EOC) and histopathologic subtypes. The study included a test set of 3,761 EOC cases and 2,722 controls and a validation set of 44,308 samples including 18,174 (10,316 serous) cases and 26,134 controls from 43 studies participating in the Ovarian Cancer Association Consortium (OCAC). Analysis of genotype data from 36 genotyped SNPs and 4600 imputed SNPs indicated that the most significant association was rs117104877 in BMAL1 (OR = 0.79, 95% CI = 0.68-0.90, p = 5.59 × 10 -4 ]. Functional analysis revealed a significant down regulation of BMAL1 expression following cMYC overexpression and increasing transformation in ovarian surface epithelial (OSE) cells as well as alternative splicing of BMAL1 exons in ovarian and granulosa cells. These results suggest that variation in circadian genes, and specifically BMAL1 , may be associated with risk of ovarian cancer, likely through disruption of hormonal pathways.

  19. Natural variation in gene expression in the early development of dauer larvae of Caenorhabditis elegans

    Directory of Open Access Journals (Sweden)

    Barker Gary LA

    2009-07-01

    Full Text Available Abstract Background The free-living nematode Caenorhabditis elegans makes a developmental decision based on environmental conditions: larvae either arrest as dauer larva, or continue development into reproductive adults. There is natural variation among C. elegans lines in the sensitivity of this decision to environmental conditions; that is, there is variation in the phenotypic plasticity of dauer larva development. We hypothesised that these differences may be transcriptionally controlled in early stage larvae. We investigated this by microarray analysis of different C. elegans lines under different environmental conditions, specifically the presence and absence of dauer larva-inducing pheromone. Results There were substantial transcriptional differences between four C. elegans lines under the same environmental conditions. The expression of approximately 2,000 genes differed between genetically different lines, with each line showing a largely line-specific transcriptional profile. The expression of genes that are markers of larval moulting suggested that the lines may be developing at different rates. The expression of a total of 89 genes was putatively affected by dauer larva or non-dauer larva-inducing conditions. Among the upstream regions of these genes there was an over-representation of DAF-16-binding motifs. Conclusion Under the same environmental conditions genetically different lines of C. elegans had substantial transcriptional differences. This variation may be due to differences in the developmental rates of the lines. Different environmental conditions had a rather smaller effect on transcription. The preponderance of DAF-16-binding motifs upstream of these genes was consistent with these genes playing a key role in the decision between development into dauer or into non-dauer larvae. There was little overlap between the genes whose expression was affected by environmental conditions and previously identified loci involved in

  20. Detector de fraude académico

    OpenAIRE

    Aranda de Miguel, Jorge

    2014-01-01

    RESUMEN: En la actualidad, el fraude académico constituye un serio problema para toda la comunidad universitaria. Herramientas de detección automatizadas pueden ser de gran utilidad para los docentes a la hora de detectar estos casos. El objeto de estudio de este proyecto es tratar de conocer la mejor manera de resolver el problema de la detección del plagio, así como conocer y explicar las diversas técnicas conocidas que existen para analizar el lenguaje humano y lenguajes de programación...

  1. Relación entre el rendimiento académico y el autorreporte del funcionamiento ejecutivo de adolescentes ecuatorianos

    Directory of Open Access Journals (Sweden)

    Carlos Ramos-Galarza

    2018-05-01

    Full Text Available En el artículo se reporta una investigación que analizó la relación entre las funciones ejecutivas y el rendimiento académico de 250 estudiantes secundarios de Quito, Ecuador. Las mediciones utilizadas consistieron en la escala para evaluar funciones ejecutivas (Efeco en el formato de autorreporte y el rendimiento académico del último año lectivo de los estudiantes. Se realizaron dos análisis: el primero de correlación sugiere que las funciones ejecutivas flexibilidad cognitiva (r = -0,18, p < 0,01, organización de materiales (r = -0,15, p < 0,01, monitorización (r = -0,22, p < 0,01, iniciativa (r = -0,24, p < 0,01, memoria de trabajo (r = -0,28, p < 0,01 y planificación (r = -0,25, p < 0,01 presentan una relación significativa e inversamente proporcional con el rendimiento académico (a mayor déficit en las funciones ejecutivas, menor rendimiento académico; el segundo análisis, basado en regresión múltiple, consideró a las funciones ejecutivas factores predictores del rendimiento académico, encontrándose una asociación estadísticamente significativa para el modelo testeado F(6,241 = 4,96, p < 0,001. El porcentaje de varianza que las funciones ejecutivas explican del rendimiento académico (r2 = 0,11 tiene relación con intervenciones realizadas previamente e invita a investigación futura en la que se realice un entrenamiento de las funciones ejecutivas para mejorar el rendimiento académico.

  2. Variations in testosterone pathway genes and susceptibility to testicular cancer in Norwegian men.

    Science.gov (United States)

    Kristiansen, W; Aschim, E L; Andersen, J M; Witczak, O; Fosså, S D; Haugen, T B

    2012-12-01

    Imbalance between the oestrogen and androgen levels in utero is hypothesized to influence testicular cancer (TC) risk. Thus, variation in genes involved in the action of sex hormones may contribute to variability of an individual's susceptibility to TC. Mutations in testosterone pathway genes may alter the level of testosterone in vivo and hypothetically the risk of developing TC. Luteinizing hormone receptor (LHR), 5α-reductase II (SRD5A2) and androgen receptor (AR) are key elements in androgen action. A case-control study comprising 651 TC cases and 313 controls in a Norwegian population was conducted for investigation of polymorphisms in the LHR, SRD5A and AR genes and their possible association with TC. A statistical significant difference was observed in patients being heterozygous for the LHR Asn312Ser polymorphism when comparing genotypes between all TC cases and controls (OR = 0.66, 95% CI = 0.48-0.89, p(adj) = 0.049). No statistically significant difference between the histological subtypes seminoma and non-seminoma was observed. Our results may suggest a possible association between genetic variation in the LHR gene and the risk of developing TC. © 2012 The Authors. International Journal of Andrology © 2012 European Academy of Andrology.

  3. Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

    Science.gov (United States)

    Purrington, Kristen S.; Slettedahl, Seth; Bolla, Manjeet K.; Michailidou, Kyriaki; Czene, Kamila; Nevanlinna, Heli; Bojesen, Stig E.; Andrulis, Irene L.; Cox, Angela; Hall, Per; Carpenter, Jane; Yannoukakos, Drakoulis; Haiman, Christopher A.; Fasching, Peter A.; Mannermaa, Arto; Winqvist, Robert; Brenner, Hermann; Lindblom, Annika; Chenevix-Trench, Georgia; Benitez, Javier; Swerdlow, Anthony; Kristensen, Vessela; Guénel, Pascal; Meindl, Alfons; Darabi, Hatef; Eriksson, Mikael; Fagerholm, Rainer; Aittomäki, Kristiina; Blomqvist, Carl; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Wang, Xianshu; Olswold, Curtis; Olson, Janet E.; Mulligan, Anna Marie; Knight, Julia A.; Tchatchou, Sandrine; Reed, Malcolm W.R.; Cross, Simon S.; Liu, Jianjun; Li, Jingmei; Humphreys, Keith; Clarke, Christine; Scott, Rodney; Fostira, Florentia; Fountzilas, George; Konstantopoulou, Irene; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Ekici, Arif B.; Hartmann, Arndt; Beckmann, Matthias W.; Hartikainen, Jaana M.; Kosma, Veli-Matti; Kataja, Vesa; Jukkola-Vuorinen, Arja; Pylkäs, Katri; Kauppila, Saila; Dieffenbach, Aida Karina; Stegmaier, Christa; Arndt, Volker; Margolin, Sara; Balleine, Rosemary; Arias Perez, Jose Ignacio; Pilar Zamora, M.; Menéndez, Primitiva; Ashworth, Alan; Jones, Michael; Orr, Nick; Arveux, Patrick; Kerbrat, Pierre; Truong, Thérèse; Bugert, Peter; Toland, Amanda E.; Ambrosone, Christine B.; Labrèche, France; Goldberg, Mark S.; Dumont, Martine; Ziogas, Argyrios; Lee, Eunjung; Dite, Gillian S.; Apicella, Carmel; Southey, Melissa C.; Long, Jirong; Shrubsole, Martha; Deming-Halverson, Sandra; Ficarazzi, Filomena; Barile, Monica; Peterlongo, Paolo; Durda, Katarzyna; Jaworska-Bieniek, Katarzyna; Tollenaar, Robert A.E.M.; Seynaeve, Caroline; Brüning, Thomas; Ko, Yon-Dschun; Van Deurzen, Carolien H.M.; Martens, John W.M.; Kriege, Mieke; Figueroa, Jonine D.; Chanock, Stephen J.; Lissowska, Jolanta; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Schneeweiss, Andreas; Tapper, William J.; Gerty, Susan M.; Durcan, Lorraine; Mclean, Catriona; Milne, Roger L.; Baglietto, Laura; dos Santos Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Van'T Veer, Laura J.; Cornelissen, Sten; Försti, Asta; Torres, Diana; Rüdiger, Thomas; Rudolph, Anja; Flesch-Janys, Dieter; Nickels, Stefan; Weltens, Caroline; Floris, Giuseppe; Moisse, Matthieu; Dennis, Joe; Wang, Qin; Dunning, Alison M.; Shah, Mitul; Brown, Judith; Simard, Jacques; Anton-Culver, Hoda; Neuhausen, Susan L.; Hopper, John L.; Bogdanova, Natalia; Dörk, Thilo; Zheng, Wei; Radice, Paolo; Jakubowska, Anna; Lubinski, Jan; Devillee, Peter; Brauch, Hiltrud; Hooning, Maartje; García-Closas, Montserrat; Sawyer, Elinor; Burwinkel, Barbara; Marmee, Frederick; Eccles, Diana M.; Giles, Graham G.; Peto, Julian; Schmidt, Marjanka; Broeks, Annegien; Hamann, Ute; Chang-Claude, Jenny; Lambrechts, Diether; Pharoah, Paul D.P.; Easton, Douglas; Pankratz, V. Shane; Slager, Susan; Vachon, Celine M.; Couch, Fergus J.

    2014-01-01

    Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16–1.33, P = 4.2 × 10−10) and EIF3H (rs799890: OR = 1.07, 95% CI 1.04–1.11, P = 8.7 × 10−6) were significantly associated with risk of low-grade breast cancer. The TACC2 signal was retained (rs17550038: OR = 1.15, 95% CI 1.07–1.23, P = 7.9 × 10−5) after adjustment for breast cancer risk SNPs in the nearby FGFR2 gene, suggesting that TACC2 is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (P = 2.1 × 10−3). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer. PMID:24927736

  4. Natural Variation of Epstein-Barr Virus Genes, Proteins, and Primary MicroRNA.

    Science.gov (United States)

    Correia, Samantha; Palser, Anne; Elgueta Karstegl, Claudio; Middeldorp, Jaap M; Ramayanti, Octavia; Cohen, Jeffrey I; Hildesheim, Allan; Fellner, Maria Dolores; Wiels, Joelle; White, Robert E; Kellam, Paul; Farrell, Paul J

    2017-08-01

    Viral gene sequences from an enlarged set of about 200 Epstein-Barr virus (EBV) strains, including many primary isolates, have been used to investigate variation in key viral genetic regions, particularly LMP1, Zp, gp350, EBNA1, and the BART microRNA (miRNA) cluster 2. Determination of type 1 and type 2 EBV in saliva samples from people from a wide range of geographic and ethnic backgrounds demonstrates a small percentage of healthy white Caucasian British people carrying predominantly type 2 EBV. Linkage of Zp and gp350 variants to type 2 EBV is likely to be due to their genes being adjacent to the EBNA3 locus, which is one of the major determinants of the type 1/type 2 distinction. A novel classification of EBNA1 DNA binding domains, named QCIGP, results from phylogeny analysis of their protein sequences but is not linked to the type 1/type 2 classification. The BART cluster 2 miRNA region is classified into three major variants through single-nucleotide polymorphisms (SNPs) in the primary miRNA outside the mature miRNA sequences. These SNPs can result in altered levels of expression of some miRNAs from the BART variant frequently present in Chinese and Indonesian nasopharyngeal carcinoma (NPC) samples. The EBV genetic variants identified here provide a basis for future, more directed analysis of association of specific EBV variations with EBV biology and EBV-associated diseases. IMPORTANCE Incidence of diseases associated with EBV varies greatly in different parts of the world. Thus, relationships between EBV genome sequence variation and health, disease, geography, and ethnicity of the host may be important for understanding the role of EBV in diseases and for development of an effective EBV vaccine. This paper provides the most comprehensive analysis so far of variation in specific EBV genes relevant to these diseases and proposed EBV vaccines. By focusing on variation in LMP1, Zp, gp350, EBNA1, and the BART miRNA cluster 2, new relationships with the known

  5. Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment.

    Science.gov (United States)

    Bernhard, Regan M; Chaponis, Jonathan; Siburian, Richie; Gallagher, Patience; Ransohoff, Katherine; Wikler, Daniel; Perlis, Roy H; Greene, Joshua D

    2016-12-01

    Moral judgments are produced through the coordinated interaction of multiple neural systems, each of which relies on a characteristic set of neurotransmitters. Genes that produce or regulate these neurotransmitters may have distinctive influences on moral judgment. Two studies examined potential genetic influences on moral judgment using dilemmas that reliably elicit competing automatic and controlled responses, generated by dissociable neural systems. Study 1 (N = 228) examined 49 common variants (SNPs) within 10 candidate genes and identified a nominal association between a polymorphism (rs237889) of the oxytocin receptor gene (OXTR) and variation in deontological vs utilitarian moral judgment (that is, judgments favoring individual rights vs the greater good). An association was likewise observed for rs1042615 of the arginine vasopressin receptor gene (AVPR1A). Study 2 (N = 322) aimed to replicate these findings using the aforementioned dilemmas as well as a new set of structurally similar medical dilemmas. Study 2 failed to replicate the association with AVPR1A, but replicated the OXTR finding using both the original and new dilemmas. Together, these findings suggest that moral judgment is influenced by variation in the oxytocin receptor gene and, more generally, that single genetic polymorphisms can have a detectable effect on complex decision processes. © The Author (2016). Published by Oxford University Press.

  6. Rapid Gene Turnover as a Significant Source of Genetic Variation in a Recently Seeded Population of a Healthcare-Associated Pathogen

    Directory of Open Access Journals (Sweden)

    Lucía Graña-Miraglia

    2017-09-01

    Full Text Available Genome sequencing has been useful to gain an understanding of bacterial evolution. It has been used for studying the phylogeography and/or the impact of mutation and recombination on bacterial populations. However, it has rarely been used to study gene turnover at microevolutionary scales. Here, we sequenced Mexican strains of the human pathogen Acinetobacter baumannii sampled from the same locale over a 3 year period to obtain insights into the microevolutionary dynamics of gene content variability. We found that the Mexican A. baumannii population was recently founded and has been emerging due to a rapid clonal expansion. Furthermore, we noticed that on average the Mexican strains differed from each other by over 300 genes and, notably, this gene content variation has accrued more frequently and faster than the accumulation of mutations. Moreover, due to its rapid pace, gene content variation reflects the phylogeny only at very short periods of time. Additionally, we found that the external branches of the phylogeny had almost 100 more genes than the internal branches. All in all, these results show that rapid gene turnover has been of paramount importance in producing genetic variation within this population and demonstrate the utility of genome sequencing to study alternative forms of genetic variation.

  7. Rasgos de personalidad y éxito académico en estudiantes de Medicina en Guatemala

    Directory of Open Access Journals (Sweden)

    Zinzi Ríos-García

    2017-03-01

    Full Text Available El rendimiento académico es explicado por la combinación de diversos factores: institucionales, personales y sociales. Indagando entre los factores personales, se realizó un estudio transversal buscando asociación entre los rasgos de personalidad, detectados mediante el Inventario Multifásico de la Personalidad de Minnesota (MMPI, con el éxito académico en estudiantes de primer ingreso de la Facultad de Ciencias Médicas de la USAC cohorte 2010 (n = 433. La muestra se dividió en dos grupos: de éxito (n = 188 y de no éxito (n = 245 y se relacionaron las10 escalas clínicas o rasgos de personalidad con el éxito académico definido como la aprobación de las ocho unidades didácticas de primer año de la carrera. Los resultados demostraron que existe asociación entre el rasgo desviación psicopática y el éxito académico (OR 1.87 p = .040. La investigación evidenció además que solo el 29.8% de los estudiantes presentó un perfil de personalidad normal y el 36% de la muestra tenía elevados dos o más rasgos patológicos de personalidad. Se concluye que el rasgo de personalidad, desviación psicopática, es el único que se asoció a éxito académico en estudiantes de primer ingreso de Medicina.

  8. Sequence variations in the FAD2 gene in seeded pumpkins.

    Science.gov (United States)

    Ge, Y; Chang, Y; Xu, W L; Cui, C S; Qu, S P

    2015-12-21

    Seeded pumpkins are important economic crops; the seeds contain various unsaturated fatty acids, such as oleic acid and linoleic acid, which are crucial for human and animal nutrition. The fatty acid desaturase-2 (FAD2) gene encodes delta-12 desaturase, which converts oleic acid to linoleic acid. However, little is known about sequence variations in FAD2 in seeded pumpkins. Twenty-seven FAD2 clones from 27 accessions of Cucurbita moschata, Cucurbita maxima, Cucurbita pepo, and Cucurbita ficifolia were obtained (totally 1152 bp; a single gene without introns). More than 90% nucleotide identities were detected among the 27 FAD2 clones. Nucleotide substitution, rather than nucleotide insertion and deletion, led to sequence polymorphism in the 27 FAD2 clones. Furthermore, the 27 FAD2 selected clones all encoded the FAD2 enzyme (delta-12 desaturase) with amino acid sequence identities from 91.7 to 100% for 384 amino acids. The same main-function domain between 47 and 329 amino acids was identified. The four species clustered separately based on differences in the sequences that were identified using the unweighted pair group method with arithmetic mean. Geographic origin and species were found to be closely related to sequence variation in FAD2.

  9. Cómo citar la bibliografía en los trabajos académicos

    OpenAIRE

    Navarro Laboulais, Cristina Teresa

    2013-01-01

    Breu guia d'estil de bibliografia basada en al Manual d'estil de Chicago. Mitjançant exemples es fan indicacions sobre com referenciar diferents tipus de documents: llibres, articles de revista, treballs acadèmics, pàgines web, pel·lícules, tuits, posts de Facebook, etc. Breve guía de estilo de bibliografía basada en el Manual de estilo de Chicago. Mediante ejemplos se dan indicaciones sobre cómo referenciar diferentes tipos de documentos: libros, artículos de revista, trabajos académicos,...

  10. Desarrollo de sistema de gestión académica de centro preuniversitario

    OpenAIRE

    Castañeda Alegría, Sergio Alfredo; Castañeda Alegría, Sergio Alfredo

    2008-01-01

    El presente informe tiene como fin desarrollar e implementar un modelo de software basado en plataforma web, tomando como caso de estudio los procesos de coordinación de la gestión académica del Centro Preuniversitario de la UNIVERSIDAD PERUANA DE LAS AMÉRICAS (UPLA), con lo que se busca informatizar los procesos académicos y administrativos de dicha coordinación. El Centro Preuniversitario de la UPLA, por ser parte de una institución educativa, necesita automatizar sus procesos de gestión...

  11. Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples.

    NARCIS (Netherlands)

    McKinney, C.; Fanciulli, M.; Merriman, M.E.; Phipps-Green, A.; Alizadeh, B.Z.; Koeleman, B.P.; Dalbeth, N.; Gow, P.J.; Harrison, A.A.; Highton, J.; Jones, P.B.; Stamp, L.K.; Steer, S.; Barrera, P.; Coenen, M.J.H.; Franke, B.; Riel, P.L.C.M. van; Vyse, T.J.; Aitman, T.J.; Radstake, T.R.D.J.; Merriman, T.R.

    2010-01-01

    OBJECTIVE: There is increasing evidence that variation in gene copy number (CN) influences clinical phenotype. The low-affinity Fcgamma receptor 3B (FCGR3B) located in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment to sites of inflammation and activation of

  12. Genetic and epigenetic variation in 5S ribosomal RNA genes reveals genome dynamics in Arabidopsis thaliana.

    Science.gov (United States)

    Simon, Lauriane; Rabanal, Fernando A; Dubos, Tristan; Oliver, Cecilia; Lauber, Damien; Poulet, Axel; Vogt, Alexander; Mandlbauer, Ariane; Le Goff, Samuel; Sommer, Andreas; Duborjal, Hervé; Tatout, Christophe; Probst, Aline V

    2018-04-06

    Organized in tandem repeat arrays in most eukaryotes and transcribed by RNA polymerase III, expression of 5S rRNA genes is under epigenetic control. To unveil mechanisms of transcriptional regulation, we obtained here in depth sequence information on 5S rRNA genes from the Arabidopsis thaliana genome and identified differential enrichment in epigenetic marks between the three 5S rDNA loci situated on chromosomes 3, 4 and 5. We reveal the chromosome 5 locus as the major source of an atypical, long 5S rRNA transcript characteristic of an open chromatin structure. 5S rRNA genes from this locus translocated in the Landsberg erecta ecotype as shown by linkage mapping and chromosome-specific FISH analysis. These variations in 5S rDNA locus organization cause changes in the spatial arrangement of chromosomes in the nucleus. Furthermore, 5S rRNA gene arrangements are highly dynamic with alterations in chromosomal positions through translocations in certain mutants of the RNA-directed DNA methylation pathway and important copy number variations among ecotypes. Finally, variations in 5S rRNA gene sequence, chromatin organization and transcripts indicate differential usage of 5S rDNA loci in distinct ecotypes. We suggest that both the usage of existing and new 5S rDNA loci resulting from translocations may impact neighboring chromatin organization.

  13. Autorregulación y rendimiento académico en la transición secundaria-universidad

    Directory of Open Access Journals (Sweden)

    María Antonieta Elvira-Valdés

    2012-01-01

    sociodemográficas en estudiantes universitarios. En esta investigación no experimental de campo participaron 172 estudiantes del Ciclo de Iniciación Universitaria de la Universidad Simón Bolívar. La autorregulación se midió mediante la Escala de Aprendizaje Autorregulado PCR (Lezama, 2005. Los resultados obtenidos sugieren niveles moderados de autorregulación en el aprendizaje, así como ligeras diferencias en cuanto al género, tipo de institución y ligera significancia entre reflexión autorregulatoria y rendimiento académico. Así mismo, las correlaciones positivas encontradas entre puntaje de ingreso e índice académico final, sugieren la asociación del rendimiento previo en el éxito académico en función de las notas.

  14. Rate variation in parasitic plants: correlated and uncorrelated patterns among plastid genes of different function

    Directory of Open Access Journals (Sweden)

    dePamphilis Claude W

    2005-02-01

    Full Text Available Abstract Background The analysis of synonymous and nonsynonymous rates of DNA change can help in the choice among competing explanations for rate variation, such as differences in constraint, mutation rate, or the strength of genetic drift. Nonphotosynthetic plants of the Orobanchaceae have increased rates of DNA change. In this study 38 taxa of Orobanchaceae and relatives were used and 3 plastid genes were sequenced for each taxon. Results Phylogenetic reconstructions of relative rates of sequence evolution for three plastid genes (rbcL, matK and rps2 show significant rate heterogeneity among lineages and among genes. Many of the non-photosynthetic plants have increases in both synonymous and nonsynonymous rates, indicating that both (1 selection is relaxed, and (2 there has been a change in the rate at which mutations are entering the population in these species. However, rate increases are not always immediate upon loss of photosynthesis. Overall there is a poor correlation of synonymous and nonsynonymous rates. There is, however, a strong correlation of synonymous rates across the 3 genes studied and the lineage-speccific pattern for each gene is strikingly similar. This indicates that the causes of synonymous rate variation are affecting the whole plastid genome in a similar way. There is a weaker correlation across genes for nonsynonymous rates. Here the picture is more complex, as could be expected if there are many causes of variation, differing from taxon to taxon and gene to gene. Conclusions The distinctive pattern of rate increases in Orobanchaceae has at least two causes. It is clear that there is a relaxation of constraint in many (though not all non-photosynthetic lineages. However, there is also some force affecting synonymous sites as well. At this point, it is not possible to tell whether it is generation time, speciation rate, mutation rate, DNA repair efficiency or some combination of these factors.

  15. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

    KAUST Repository

    Phelan, Jody E.; Coll, Francesc; Bergval, Indra; Anthony, Richard M.; Warren, Rob; Sampson, Samantha L.; Gey van Pittius, Nicolaas C.; Glynn, Judith R.; Crampin, Amelia C.; Alves, Adriana; Bessa, Theolis Barbosa; Campino, Susana; Dheda, Keertan; Grandjean, Louis; Hasan, Rumina; Hasan, Zahra; Miranda, Anabela; Moore, David; Panaiotov, Stefan; Perdigao, Joao; Portugal, Isabel; Sheen, Patricia; de Oliveira Sousa, Erivelton; Streicher, Elizabeth M.; van Helden, Paul D.; Viveiros, Miguel; Hibberd, Martin L.; Pain, Arnab; McNerney, Ruth; Clark, Taane G.

    2016-01-01

    . tuberculosis complex genomes and long read sequence data were used to validate the approach. SNP analysis revealed that variation in the majority of the 168 pe/ppe genes studied was consistent with lineage. Several recombination hotspots were identified

  16. Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015.

    Science.gov (United States)

    Kim, Dae-Won; Kim, You-Jin; Park, Sung Han; Yun, Mi-Ran; Yang, Jeong-Sun; Kang, Hae Ji; Han, Young Woo; Lee, Han Saem; Kim, Heui Man; Kim, Hak; Kim, A-Reum; Heo, Deok Rim; Kim, Su Jin; Jeon, Jun Ho; Park, Deokbum; Kim, Joo Ae; Cheong, Hyang-Min; Nam, Jeong-Gu; Kim, Kisoon; Kim, Sung Soon

    2016-01-01

    An outbreak of nosocomial infections with Middle East respiratory syndrome coronavirus occurred in South Korea in May 2015. Spike glycoprotein genes of virus strains from South Korea were closely related to those of strains from Riyadh, Saudi Arabia. However, virus strains from South Korea showed strain-specific variations.

  17. Académico Alberto Amarís Mora

    Directory of Open Access Journals (Sweden)

    Fernando Sánchez-Torres

    2017-04-01

    Full Text Available Fragmento Con gran pesadumbre cumplo el encargo de escribir esta nota necrológica, pues el personaje de quien debo ocuparme, Alberto Amarís Mora, dejó indeleble su impronta en mi recuerdo. Por eso, además de registrar su desaparición en estas páginas, quiero rendirle un homenaje póstumo de admiración y de afectuosa gratitud. Conocí al académico Amarís Mora hace sesenta años, cuando él era médico interno titular de la Clínica Obstétrica en el Instituto Materno Infantil y yo estudiante interno rotatorio de dicha asignatura en la Facultad de Medicina de la Universidad Nacional de Colombia. Ni él ni yo imaginábamos que con el paso del tiempo iríamos a compartir juntos dificultades y satisfacciones académicas y administrativas. En efecto, más adelante nos encontraríamos desempeñando ambos funciones profesorales, él como catedrático de Pediatría y yo de Obstetricia, disciplinas muy afines, que obligaban a trabajar de consuno.

  18. Intercâmbio acadêmico cultural internacional: uma experiência de crescimento pessoal e científico

    Directory of Open Access Journals (Sweden)

    Indiara Sartori Dalmolin

    2013-06-01

    Full Text Available Este estudo objetivou descrever a experiência discente ao integrar um programa de mobilidade acadêmica internacional, durante a graduação em enfermagem. Trata-se de relato da vivência acadêmica em Portugal, na Universidade do Algarve, viabilizada pela Universidade Federal de Santa Maria, Rio Grande do Sul, Brasil. A experiência de intercâmbio realizada no período de seis meses, possibilitou a aquisição de novos conhecimentos científicos e culturais, inclusive inovações de tecnologias em saúde, desenvolvimento de pesquisa e vínculos acadêmicos. Como contribuições, espera-se estimular e intensificar a mobilidade internacional especialmente no âmbito da graduação, considerando a sua importância para o aperfeiçoamento da formação acadêmica e a excelência do ensino superior brasileiro por meio do intercâmbio científico e cultural no exterior.

  19. Dietary Variation and Evolution of Gene Copy Number among Dog Breeds.

    Directory of Open Access Journals (Sweden)

    Taylor Reiter

    Full Text Available Prolonged human interactions and artificial selection have influenced the genotypic and phenotypic diversity among dog breeds. Because humans and dogs occupy diverse habitats, ecological contexts have likely contributed to breed-specific positive selection. Prior to the advent of modern dog-feeding practices, there was likely substantial variation in dietary landscapes among disparate dog breeds. As such, we investigated one type of genetic variant, copy number variation, in three metabolic genes: glucokinase regulatory protein (GCKR, phytanol-CoA 2-hydroxylase (PHYH, and pancreatic α-amylase 2B (AMY2B. These genes code for proteins that are responsible for metabolizing dietary products that originate from distinctly different food types: sugar, meat, and starch, respectively. After surveying copy number variation among dogs with diverse dietary histories, we found no correlation between diet and positive selection in either GCKR or PHYH. Although it has been previously demonstrated that dogs experienced a copy number increase in AMY2B relative to wolves during or after the dog domestication process, we demonstrate that positive selection continued to act on amylase copy number in dog breeds that consumed starch-rich diets in time periods after domestication. Furthermore, we found that introgression with wolves is not responsible for deterioration of positive selection on AMY2B among diverse dog breeds. Together, this supports the hypothesis that the amylase copy number expansion is found universally in dogs.

  20. A Leitura e o Consumo de Literatura Não Acadêmica e o Profissional de Comunicação em Formação: Um Estudo Entre os Acadêmicos de Comunicação da Univali

    Directory of Open Access Journals (Sweden)

    Bruna Michelin Pinto

    2013-12-01

    Full Text Available O presente estudo teve como objetivo conhecer os hábitos de consumo e leitura não acadêmica presentes entre os alunos de Comunicação Social da Univali – SC, bem como o comportamento de compra e as influências recebidas no processo de compra. Para isso realizou-se uma pesquisa quantitativa descritiva, de procedimento survey. A amostra de 143 acadêmicos foi estratificada em dois grupos - iniciantes e concluintes. Os resultados indicaram que há limitado interesse na leitura entre os acadêmicos e a comunicação de marketing possui baixo nível de impacto em suas decisões de compra.

  1. Habilidades académicas en estudiantes de nuevo ingreso a la Universidad del Zulia

    Directory of Open Access Journals (Sweden)

    Mariana Fernández Reina

    2015-01-01

    Full Text Available Al inicio de su carrera universitaria algunos jóvenes demuestran no poseer las habilidades académicas necesarias para alcanzar la culminación de sus estudios. Esta investigación se enfoca en diagnosticar las habilidades académicas de los estudiantes cuando ingresan a la universidad. Se plantea una investigación descriptiva, con un diseño transeccional, univariable, de campo, no experimental. La población de estudio estuvo conformada por 940 estudiantes que ingresaron al Núcleo Costa Oriental del Lago de la Universidad del Zulia en las carreras de Ingeniería, Ciencias Económicas y Sociales, y Educación, para el primer período de 2012. La muestra seleccionada fue no probabilística, conformada por 179 estudiantes. El instrumento empleado para la recolección de datos fue la escala de habilidades académicas en estudiantes universitarios, compuesta por 40 reactivos, tipo Likert, la cual alcanzó una confiabilidad alfa de Cronbach de 0,86. Según los resultados los estudiantes de nuevo ingreso poseen un nivel bajo de habilidades académicas (organización; empleo de técnicas; motivación, lo cual no les permite abordar con éxito los retos de la vida universitaria. Se sugiere reforzar las mismas a través de la práctica.

  2. Los servicios móviles de información en el marco de la biblioteca académica

    Directory of Open Access Journals (Sweden)

    Eder Ávila Barrientos

    2015-01-01

    Full Text Available El objetivo de este artículo de revisión bibliográfica es analizar la integración de los servicios móviles de información en las bibliotecas académicas, para esclarecer los elementos teóricos y metodológicos inmersos en la generación de servicios bibliotecarios de información innovadores. Los servicios móviles de información en las bibliotecas académicas son utilizados por las diversas comunidades de usuarios que se presentan en este tipo de bibliotecas. Los dispositivos móviles hacen posible la consulta remota de recursos digitales de información mediante la utilización de aplicaciones móviles generadas o adaptadas por y para las bibliotecas académicas. Este fenómeno ha provocado la aparición de la biblioteca académica inteligente, caracterizada por la innovación tecnológica de sus procesos y el uso de tecnologías móviles para el apoyo de las actividades académicas y de investigación en las universidades.

  3. Intra and Interspecific Variations of Gene Expression Levels in Yeast Are Largely Neutral: (Nei Lecture, SMBE 2016, Gold Coast).

    Science.gov (United States)

    Yang, Jian-Rong; Maclean, Calum J; Park, Chungoo; Zhao, Huabin; Zhang, Jianzhi

    2017-09-01

    It is commonly, although not universally, accepted that most intra and interspecific genome sequence variations are more or less neutral, whereas a large fraction of organism-level phenotypic variations are adaptive. Gene expression levels are molecular phenotypes that bridge the gap between genotypes and corresponding organism-level phenotypes. Yet, it is unknown whether natural variations in gene expression levels are mostly neutral or adaptive. Here we address this fundamental question by genome-wide profiling and comparison of gene expression levels in nine yeast strains belonging to three closely related Saccharomyces species and originating from five different ecological environments. We find that the transcriptome-based clustering of the nine strains approximates the genome sequence-based phylogeny irrespective of their ecological environments. Remarkably, only ∼0.5% of genes exhibit similar expression levels among strains from a common ecological environment, no greater than that among strains with comparable phylogenetic relationships but different environments. These and other observations strongly suggest that most intra and interspecific variations in yeast gene expression levels result from the accumulation of random mutations rather than environmental adaptations. This finding has profound implications for understanding the driving force of gene expression evolution, genetic basis of phenotypic adaptation, and general role of stochasticity in evolution. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  4. Procrastinação académica a Matemática em alunos de Maputo: Estudos com adolescentes

    OpenAIRE

    Fulano, Celso Simão

    2017-01-01

    Tese de Doutoramento em Psicologia Aplicada A presente tese pretende contribuir para a literatura no domínio da procrastinação académica, analisando algumas variáveis que ajudam a explicar a procrastinação académica em matemática. Pretendemos explorar a perspetiva dos adolescentes moçambicanos em aspetos tais como: tarefas nas quais os alunos procrastinam com frequência, os antecedentes da procrastinação e as consequências da procrastinação académica percebidas pelos alunos. Al...

  5. El plagio académico: formar en competencias y buenas prácticas universitarias

    OpenAIRE

    Alfaro Torres, Paloma; Juan Juárez, Teresa de

    2014-01-01

    El plagio académico es una práctica demasiado frecuente entre los estudiantes universitarios ya que las nuevas tecnologías, y en especial, Internet permiten realizarlo con facilidad. Se analiza el concepto de plagio desde diversos puntos de vista y se profundiza en las competencias informacionales del uso ético y legal de la información que debe ser acometido desde diversos frentes para inculcar la honestidad académica en la enseñanza superior

  6. Modeling of biodiesel production in algae cultivation with anaerobic digestion (ACAD)

    Energy Technology Data Exchange (ETDEWEB)

    Morken, John [Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences (UMB), PO Box 5003, Drøbakveien 31, Aas, N-1432 (Norway); Sapci, Zehra [Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences (UMB), PO Box 5003, Drøbakveien 31, Aas, N-1432 (Norway); Department of Environmental Engineering, Faculty of Engineering and Architecture, Bitlis Eren University, 13000 Bitlis (Turkey); Strømme, Jon Eivind T. [Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences (UMB), PO Box 5003, Drøbakveien 31, Aas, N-1432 (Norway)

    2013-09-01

    This study presents a model of an ecotechnology that combines algae cultivation with anaerobic digestion in order to recycle nutrients and to reduce the need for external energy. The concept is to convert organic waste into several products, such as electricity, biodiesel and organic fertilizer. It is labeled as the ACAD biorefinery. The simulation model of the ACAD biorefinery proved itself to be a powerful tool for understanding the symbioses and dynamics of the system, and therefore also a good tool for reaching political decisions. The model shows that the ACAD biorefinery could be totally independent of external energy supplies. Energy calculations indicate that more energy can be produced by combining the algae cultivation and anaerobic digestion processes. For every unit of energy entering the system in feedstock, 0.6 units of energy are exported as either biodiesel or electricity. The exported electricity accounts for approximately 30% of the total exported energy, while the remaining 70% is exported as biodiesel. By producing its own energy, the biorefinery improves its renewability and level of carbon neutrality. - Highlights: • The model combines algae cultivation with anaerobic digestion. • In the model nutrients and carbon dioxide are recycled. • Organic waste is converted into electrical power, biodiesel and organic fertilizer. • Results showed that more energy can be produced by combining the processes.

  7. Modeling of biodiesel production in algae cultivation with anaerobic digestion (ACAD)

    International Nuclear Information System (INIS)

    Morken, John; Sapci, Zehra; Strømme, Jon Eivind T.

    2013-01-01

    This study presents a model of an ecotechnology that combines algae cultivation with anaerobic digestion in order to recycle nutrients and to reduce the need for external energy. The concept is to convert organic waste into several products, such as electricity, biodiesel and organic fertilizer. It is labeled as the ACAD biorefinery. The simulation model of the ACAD biorefinery proved itself to be a powerful tool for understanding the symbioses and dynamics of the system, and therefore also a good tool for reaching political decisions. The model shows that the ACAD biorefinery could be totally independent of external energy supplies. Energy calculations indicate that more energy can be produced by combining the algae cultivation and anaerobic digestion processes. For every unit of energy entering the system in feedstock, 0.6 units of energy are exported as either biodiesel or electricity. The exported electricity accounts for approximately 30% of the total exported energy, while the remaining 70% is exported as biodiesel. By producing its own energy, the biorefinery improves its renewability and level of carbon neutrality. - Highlights: • The model combines algae cultivation with anaerobic digestion. • In the model nutrients and carbon dioxide are recycled. • Organic waste is converted into electrical power, biodiesel and organic fertilizer. • Results showed that more energy can be produced by combining the processes

  8. 5. Neuromarketing: uma nova disciplina acadêmica?

    Directory of Open Access Journals (Sweden)

    Eric David Cohen

    2017-12-01

    Full Text Available Através da aplicação de técnicas neurocientíficas, o Neuromarketing busca entender como ocorrem os processos de decisão de compra. Verifica-se que há um grande movimento em torno do Neuromarketing no ambiente empresarial, apontando que o desenvolvimento desta nova área de conhecimento, bem como a sua possível autonomia, estão em desenvolvimento. Por meio de um estudo exploratório, mapeou-se a construção deste campo de conhecimento no tempo, levando à formação de uma possível nova disciplina científica e acadêmica, assim como verificar a sua origem interdisciplinar. Ademais, apresenta-se a construção de um mapa a partir de dados secundários, de modo a demonstrar a percepção da história e das contribuições potenciais do Neuromarketing, a partir de uma análise da produção científica na área. A partir de um conjunto de dados levantados, conclui-se que existe uma dinâmica de construção do Neuromarketing em torno dos diferentes atores na academia e nos negócios, levando à formulação de hipóteses quanto à maturidade desta nova disciplina acadêmica.

  9. Extensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure.

    Science.gov (United States)

    Gordon, Sean P; Contreras-Moreira, Bruno; Woods, Daniel P; Des Marais, David L; Burgess, Diane; Shu, Shengqiang; Stritt, Christoph; Roulin, Anne C; Schackwitz, Wendy; Tyler, Ludmila; Martin, Joel; Lipzen, Anna; Dochy, Niklas; Phillips, Jeremy; Barry, Kerrie; Geuten, Koen; Budak, Hikmet; Juenger, Thomas E; Amasino, Richard; Caicedo, Ana L; Goodstein, David; Davidson, Patrick; Mur, Luis A J; Figueroa, Melania; Freeling, Michael; Catalan, Pilar; Vogel, John P

    2017-12-19

    While prokaryotic pan-genomes have been shown to contain many more genes than any individual organism, the prevalence and functional significance of differentially present genes in eukaryotes remains poorly understood. Whole-genome de novo assembly and annotation of 54 lines of the grass Brachypodium distachyon yield a pan-genome containing nearly twice the number of genes found in any individual genome. Genes present in all lines are enriched for essential biological functions, while genes present in only some lines are enriched for conditionally beneficial functions (e.g., defense and development), display faster evolutionary rates, lie closer to transposable elements and are less likely to be syntenic with orthologous genes in other grasses. Our data suggest that differentially present genes contribute substantially to phenotypic variation within a eukaryote species, these genes have a major influence in population genetics, and transposable elements play a key role in pan-genome evolution.

  10. Factores que favorecen el desarrollo de una actitud positiva hacia las actividades académicas

    Directory of Open Access Journals (Sweden)

    María Luisa Naranjo Pereira

    2010-01-01

    Full Text Available Este artículo presenta una investigación de tipo descriptivo, cuyo objetivo es analizar los factores personales que favorecen el desarrollo de una actitud positiva hacia las actividades académicas, de acuerdo con la opinión de dos grupos de estudiantes de décimo año. Ella está constituida por un constructo principal: la actitud positiva hacia las actividades académicas, y un subconstructo: los factores personales que favorecen esas actitudes. Los aspectos que integran este subconstructo son la autoestima positiva, la motivación, la comunicación asertiva y el manejo del estrés. La introducción y el referente teórico evidencian la relación que existe entre estos factores, las actitudes hacia el aprendizaje y los logros académicos de la población estudiantil. De acuerdo con los resultados obtenidos, se concluye que la población estudiantil concede importancia tanto a factores internos como externos relacionados con la motivación, y los percibe como significativos para el desarrollo de actitudes positivas hacia las actividades académicas. De igual forma sucede con el hecho de poseer una autoestima positiva, saber comunicarse asertivamente y poder manejar el estrés de forma adecuada. Se recomienda, por lo tanto, que las instituciones educativas presten especial atención al desarrollo socio-emocional del estudiantado, mediante la realización de programas que favorezcan el logro de su motivación académica, un mejoramiento de su autoestima, la habilidad para comunicarse asertivamente y el afrontamiento apropiado del estrés.

  11. Sweet taste receptor gene variation and aspartame taste in primates and other species.

    Science.gov (United States)

    Li, Xia; Bachmanov, Alexander A; Maehashi, Kenji; Li, Weihua; Lim, Raymond; Brand, Joseph G; Beauchamp, Gary K; Reed, Danielle R; Thai, Chloe; Floriano, Wely B

    2011-06-01

    Aspartame is a sweetener added to foods and beverages as a low-calorie sugar replacement. Unlike sugars, which are apparently perceived as sweet and desirable by a range of mammals, the ability to taste aspartame varies, with humans, apes, and Old World monkeys perceiving aspartame as sweet but not other primate species. To investigate whether the ability to perceive the sweetness of aspartame correlates with variations in the DNA sequence of the genes encoding sweet taste receptor proteins, T1R2 and T1R3, we sequenced these genes in 9 aspartame taster and nontaster primate species. We then compared these sequences with sequences of their orthologs in 4 other nontasters species. We identified 9 variant sites in the gene encoding T1R2 and 32 variant sites in the gene encoding T1R3 that distinguish aspartame tasters and nontasters. Molecular docking of aspartame to computer-generated models of the T1R2 + T1R3 receptor dimer suggests that species variation at a secondary, allosteric binding site in the T1R2 protein is the most likely origin of differences in perception of the sweetness of aspartame. These results identified a previously unknown site of aspartame interaction with the sweet receptor and suggest that the ability to taste aspartame might have developed during evolution to exploit a specialized food niche.

  12. Copy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration

    Directory of Open Access Journals (Sweden)

    Norshakimah Md Bakri

    2018-07-01

    Full Text Available Background: Several studies in various populations have been conducted to determine candidate genes that could contribute to age-related macular degeneration (AMD pathogenesis. Objective: The present study was undertaken to determine the association of high temperature requirement A-1 (HTRA1, vascular endothelial growth factor (VEGF and very-low-density receptor (VLDR genes with wet AMD subjects in Malaysia. Methods: A total of 125 subjects with wet AMD and 120 subjects without AMD from the Malaysian population were selected for this study. Genomic DNA was extracted and copy number variations (CNVs were determined using quantitative real-time Polymerase Chain Reaction (qPCR and comparison between the two groups was done. The demographic characteristics were also recorded. Statistical analysis was carried out using software where a level of P  0.05. Conclusion: Observations of an association between CNVs of VEGF gene and wet AMD have revealed that the CNVs of VEGF gene appears to be a possible contributor to wet AMD subjects in Malaysia. Keywords: Age-related macular degeneration, Copy number variations, VEGF, HTRA1, VLDR genes and Malaysia

  13. Effects of vertebral number variations on carcass traits and genotyping of Vertnin candidate gene in Kazakh sheep

    Directory of Open Access Journals (Sweden)

    Zhifeng Zhang

    2017-09-01

    Full Text Available Objective The vertebral number is associated with body length and carcass traits, which represents an economically important trait in farm animals. The variation of vertebral number has been observed in a few mammalian species. However, the variation of vertebral number and quantitative trait loci in sheep breeds have not been well addressed. Methods In our investigation, the information including gender, age, carcass weight, carcass length and the number of thoracic and lumbar vertebrae from 624 China Kazakh sheep was collected. The effect of vertebral number variation on carcass weight and carcass length was estimated by general linear model. Further, the polymorphic sites of Vertnin (VRTN gene were identified by sequencing, and the association of the genotype and vertebral number variation was analyzed by the one-way analysis of variance model. Results The variation of thoracolumbar vertebrae number in Kazakh sheep (18 to 20 was smaller than that in Texel sheep (17 to 21. The individuals with 19 thoracolumbar vertebrae (T13L6 were dominant in Kazakh sheep (79.2%. The association study showed that the numbers of thoracolumbar vertebrae were positively correlated with the carcass length and carcass weight, statistically significant with carcass length. To investigate the association of thoracolumbar vertebrae number with VRTN gene, we genotyped the VRTN gene. A total of 9 polymorphic sites were detected and only a single nucleotide polymorphism (SNP (rs426367238 was suggested to associate with thoracic vertebral number statistically. Conclusion The variation of thoracolumbar vertebrae number positively associated with the carcass length and carcass weight, especially with the carcass length. VRTN gene polymorphism of the SNP (rs426367238 with significant effect on thoracic vertebral number could be as a candidate marker to further evaluate its role in influence of thoracolumbar vertebral number.

  14. Effects of vertebral number variations on carcass traits and genotyping of Vertnin candidate gene in Kazakh sheep.

    Science.gov (United States)

    Zhang, Zhifeng; Sun, Yawei; Du, Wei; He, Sangang; Liu, Mingjun; Tian, Changyan

    2017-09-01

    The vertebral number is associated with body length and carcass traits, which represents an economically important trait in farm animals. The variation of vertebral number has been observed in a few mammalian species. However, the variation of vertebral number and quantitative trait loci in sheep breeds have not been well addressed. In our investigation, the information including gender, age, carcass weight, carcass length and the number of thoracic and lumbar vertebrae from 624 China Kazakh sheep was collected. The effect of vertebral number variation on carcass weight and carcass length was estimated by general linear model. Further, the polymorphic sites of Vertnin ( VRTN ) gene were identified by sequencing, and the association of the genotype and vertebral number variation was analyzed by the one-way analysis of variance model. The variation of thoracolumbar vertebrae number in Kazakh sheep (18 to 20) was smaller than that in Texel sheep (17 to 21). The individuals with 19 thoracolumbar vertebrae (T13L6) were dominant in Kazakh sheep (79.2%). The association study showed that the numbers of thoracolumbar vertebrae were positively correlated with the carcass length and carcass weight, statistically significant with carcass length. To investigate the association of thoracolumbar vertebrae number with VRTN gene, we genotyped the VRTN gene. A total of 9 polymorphic sites were detected and only a single nucleotide polymorphism (SNP) (rs426367238) was suggested to associate with thoracic vertebral number statistically. The variation of thoracolumbar vertebrae number positively associated with the carcass length and carcass weight, especially with the carcass length. VRTN gene polymorphism of the SNP (rs426367238) with significant effect on thoracic vertebral number could be as a candidate marker to further evaluate its role in influence of thoracolumbar vertebral number.

  15. No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes

    DEFF Research Database (Denmark)

    Sørensen, Mette; Nygaard, Marianne; Debrabant, Birgit

    2016-01-01

    additional genes repeatedly considered as candidates for human longevity: APOE, APOA4, APOC3, ACE, CETP, HFE, IL6, IL6R, MTHFR, TGFB1, SIRTs 1, 3, 6; and HSPAs 1A, 1L, 14. Altogether, 1,049 single nucleotide polymorphisms (SNPs) were genotyped in 1,088 oldest-old (age 92-93 years) Danes and analysed......In this study we explored the association between aging-related phenotypes previously reported to predict survival in old age and variation in 77 genes from the DNA repair pathway, 32 genes from the growth hormone 1/ insulin-like growth factor 1/insulin (GH/IGF-1/INS) signalling pathway and 16...... in the relevant phenotype over time (7 years of follow-up) and none of the SNPs could be confirmed in a replication sample of 1,281 oldest-old Danes (age 94-100). Hence, our study does not support association between common variation in the investigated longevity candidate genes and aging-related phenotypes...

  16. PAX6 gene variations associated with aniridia in south India

    Directory of Open Access Journals (Sweden)

    Shashikant Shetty

    2004-04-01

    Full Text Available Abstract Background Mutations in the transcription factor gene PAX6 have been shown to be the cause of the aniridia phenotype. The purpose of this study was to analyze patients with aniridia to uncover PAX6 gene mutations in south Indian population. Methods Total genomic DNA was isolated from peripheral blood of twenty-eight members of six clinically diagnosed aniridia families and 60 normal healthy controls. The coding exons of the human PAX6 gene were amplified by PCR and allele specific variations were detected by single strand conformation polymorphism (SSCP followed by automated sequencing. Results The sequencing results revealed novel PAX6 mutations in three patients with sporadic aniridia: c.715ins5, [c.1201delA; c.1239A>G] and c.901delA. Two previously reported nonsense mutations were also found: c.482C>A, c.830G>A. A neutral polymorphism was detected (IVS9-12C>T at the boundary of intron 9 and exon 10. The two nonsense mutations found in the coding region of human PAX6 gene are reported for the first time in the south Indian population. Conclusion The genetic analysis confirms that haploinsuffiency of the PAX6 gene causes the classic aniridia phenotype. Most of the point mutations detected in our study results in stop codons. Here we add three novel PAX6 gene mutations in south Indian population to the existing spectrum of mutations, which is not a well-studied ethnic group. Our study supports the hypothesis that a mutation in the PAX6 gene correlates with expression of aniridia.

  17. Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex

    Directory of Open Access Journals (Sweden)

    Michelle N. Arbeitman

    2016-07-01

    Full Text Available Sex differences in gene expression have been widely studied in Drosophila melanogaster. Sex differences vary across strains, but many molecular studies focus on only a single strain, or on genes that show sexually dimorphic expression in many strains. How extensive variability is and whether this variability occurs among genes regulated by sex determination hierarchy terminal transcription factors is unknown. To address these questions, we examine differences in sexually dimorphic gene expression between two strains in Drosophila adult head tissues. We also examine gene expression in doublesex (dsx mutant strains to determine which sex-differentially expressed genes are regulated by DSX, and the mode by which DSX regulates expression. We find substantial variation in sex-differential expression. The sets of genes with sexually dimorphic expression in each strain show little overlap. The prevalence of different DSX regulatory modes also varies between the two strains. Neither the patterns of DSX DNA occupancy, nor mode of DSX regulation explain why some genes show consistent sex-differential expression across strains. We find that the genes identified as regulated by DSX in this study are enriched with known sites of DSX DNA occupancy. Finally, we find that sex-differentially expressed genes and genes regulated by DSX are highly enriched on the fourth chromosome. These results provide insights into a more complete pool of potential DSX targets, as well as revealing the molecular flexibility of DSX regulation.

  18. A relative variation-based method to unraveling gene regulatory networks.

    Directory of Open Access Journals (Sweden)

    Yali Wang

    Full Text Available Gene regulatory network (GRN reconstruction is essential in understanding the functioning and pathology of a biological system. Extensive models and algorithms have been developed to unravel a GRN. The DREAM project aims to clarify both advantages and disadvantages of these methods from an application viewpoint. An interesting yet surprising observation is that compared with complicated methods like those based on nonlinear differential equations, etc., methods based on a simple statistics, such as the so-called Z-score, usually perform better. A fundamental problem with the Z-score, however, is that direct and indirect regulations can not be easily distinguished. To overcome this drawback, a relative expression level variation (RELV based GRN inference algorithm is suggested in this paper, which consists of three major steps. Firstly, on the basis of wild type and single gene knockout/knockdown experimental data, the magnitude of RELV of a gene is estimated. Secondly, probability for the existence of a direct regulation from a perturbed gene to a measured gene is estimated, which is further utilized to estimate whether a gene can be regulated by other genes. Finally, the normalized RELVs are modified to make genes with an estimated zero in-degree have smaller RELVs in magnitude than the other genes, which is used afterwards in queuing possibilities of the existence of direct regulations among genes and therefore leads to an estimate on the GRN topology. This method can in principle avoid the so-called cascade errors under certain situations. Computational results with the Size 100 sub-challenges of DREAM3 and DREAM4 show that, compared with the Z-score based method, prediction performances can be substantially improved, especially the AUPR specification. Moreover, it can even outperform the best team of both DREAM3 and DREAM4. Furthermore, the high precision of the obtained most reliable predictions shows that the suggested algorithm may be

  19. El Profesor Académico, Dr. Pablo Gómez Martínez.

    Directory of Open Access Journals (Sweden)

    Zoilo Cuéllar-Montoya

    2007-12-01

    Más adelante, en la misma Presidencia de la Academia del Profesor Pedro José Almánzar Vargas (1963 – 1965, fue promovido Gómez Martínez a la categoría de Miembro de Número(2,10 con el trabajo “Ilio-cisto-plastia con colgajo sero-muscular invertido y reconstrucción de vejigas funcionales” (2,11. En la sesión ordinaria de la Academia del día 12 de marzo de 1964, el Académico Correspondiente Gómez Martínez presentó el trabajo mencionado(2,12 y, en la sesión ordinaria del día 14 de mayo de 1964, en virtud de haber quedado vacantes las sillas de los Señores Académicos de Número Jaime Jaramillo Arango, fallecido en Bogotá, el 31 de julio de 1962(2,13, Manuel José Luque Guevara, retirado por precarias condiciones de salud(2,14, y Fernando Torres Restrepo, trasladado definitivamente a los Estados Unidos(2,15, la Academia, en votación secreta, eligió, como Miembros de Número, a los Señores Académicos Correspondientes Pablo Gómez Martínez, Alfredo Artunduaga y J. Hernando Hernández Garay(2,16...

  20. Perfil sociodemográfico de los estudiantes universitarios sin progreso académico y la relación entre el apoyo psicosocial con enfoque de resiliencia y el éxito académico en los estudiantes de primer año de universidad

    OpenAIRE

    Bueno Delgado, Georgina

    2005-01-01

    Esta investigación incluye tres fases: 1) Desarrollar un perfil sociodemográfico de los estudiantes de la Universidad de Puerto Rico, Recinto de Río Piedras sin progreso académico y explorar las razones por las cuales obtuvieron fracaso académico. 2) Desarrollar un modelo de apoyo psicosocial dirigido a los estudiantes universitarios de primer año con el objetivo de evitar su fracaso académico. 3) Implantar este modelo a un grupo de 20 estudiantes de la Universidad de Puerto Rico, Recinto de ...

  1. Mutational landscape of the human Y chromosome-linked genes ...

    Indian Academy of Sciences (India)

    arsenic pollution (Ali and Ali 2010), cases of prostate can- cer (Pathak et al. ...... of function of the KiSS1-derived peptide receptor GPR54. Proc. Natl. Acad. Sci. .... genes and loci in prostate cancer cell lines DU145 and LNCaP. BMC Genomics ...

  2. Procrastinación general y académica en una muestra de estudiantes de secundaria de Lima metropolitana

    OpenAIRE

    Álvarez-Blas, Óscar Ricardo; Universidad de Lima (Perú)

    2010-01-01

    Se estudió la presencia de la procrastinación general y académica en un grupo de estudiantes de secundaria (N = 235) de ambos géneros pertenecientes a colegios no estatales de Lima metropolitana, para lo cual se utilizó la Escala de Procrastinación General y Académica (Busko, 1998). Sobre la base del análisis de los resultados se encontró que la procrastinación académica era mayor que la general, y no existían diferencias significativas según rol genérico y el grado de estudios. Se adjunta el...

  3. El perfil profesional y académico de los presidentes municipales del Estado de México, 2009-2012

    OpenAIRE

    Rafael Cedillo Delgado

    2014-01-01

    Este artículo analiza el perfil profesional y académico de los ediles mexiquenses en el periodo 2009-2012. Con base en datos oficiales e información periodística, se compara su perfil profesional y académico por categoría de urbanización de los municipios, profesión, grado de estudios, género y pertenencia partidista. Los resultados muestran que la urbanización de los ayuntamientos y la filiación partidista no se relacionan con el grado académico. El nivel educativo es aceptable, pues dos ter...

  4. Adaptação, rendimento, evasão e vivências acadêmicas no ensino superior: revisão da literatura

    Directory of Open Access Journals (Sweden)

    Cristiane Maria Barra da Matta

    Full Text Available Resumo O início da vida acadêmica é um período de grandes mudanças para o estudante, que muitas vezes é tratado de forma infantilizada no ensino médio e se depara com as responsabilidades e exigências da universidade. O presente trabalho teve como objetivo revisar artigos, publicados entre 2005 e 2015, referentes à adaptação universitária relacionada às vivências acadêmicas, rendimento e evasão, no curso de Engenharia. Para tanto, foram realizadas pesquisas nas seguintes bases de dados eletrônicos: Biblioteca Virtual de Saúde (BVS, Scielo Brasil e Portal de Periódicos Eletrônicos de Psicologia (PePSIC.Utilizaram-se os descritores: adaptação acadêmica, vivências acadêmicas, rendimento acadêmico, evasão e engenharia. Foram encontrados 55 artigos, porém somente 16 atenderam os critérios de inclusão. A maioria dos artigos empíricos relacionados (66,7% utiliza o instrumento Questionário de Vivências Acadêmicas (QVA ou Questionário de Vivências Acadêmicas - versão reduzida (QVA-r. Dois deles (13,3% utilizaram esse instrumento conjuntamente com o Inventário de Habilidades Sociais e outros três (20,0% com o Questionário de caracterização dos estudantes. Conclui-se que os relacionamentos interpessoais podem favorecer o rendimento acadêmico e adiar a evasão, assim como os serviços de apoio aos estudantes; e constatou-se a escassez do tema em questão nos cursos de engenharia.

  5. Éxito académico de la segunda generación de inmigrantes en E.E.U.U.

    Directory of Open Access Journals (Sweden)

    Rosa María Rodríguez Izquierdo

    2010-01-01

    Full Text Available Los alumnos de minorías étnicas entran en la escuela desde diversos orígenes, con diferentes experiencias de la inmigración y recursos según las familias de las que proceden. Este artículo trata de responder a dos cuestiones: (1 ¿Por qué algunos estudiantes tienen éxito mientras otros luchan académicamente y no logran conseguirlo?, (2 ¿Hasta qué punto ayuda o desfavorece la consecución del éxito académico el mantenimiento de la cultura de origen? Educadores, investigadores y políticos, con frecuencia, han creído que los niños y niñas inmigrantes tienen mayor éxito en la escuela si ellos y sus familias se asimilan culturalmente y asumen las características prevalentes en la sociedad mayoritaria. Por lo tanto, se piensa a menudo en la retención étnica (como por ejemplo, mantener sus valores étnicos y prácticas como un factor importante para no tener éxito académico. Sin embargo, basado en evidencias empíricas, la asimilación segmentada es en la actualidad un predictor de mayores logros académicos en los hijos de familias inmigrantes. Este artículo examina los diferentes aspectos del proceso de adaptación a las escuelas de la segunda generación de inmigrantes y las distintas hipótesis alternativas en estos procesos y sus determinantes.Children of ethnic minorities come from diverse backgrounds and enter school with different family migration experiences and resources.This paper addresses two basic questions:(1 Why some students do wellatschool while othersstrive to obtain it and do notsucceed?,(2 To whatextent the maintenance oftheir original culture help or make more difficult their academic achievement? Educators, researchers and policymakers often believe that immigrant children perform better in school if they and their families culturally assimilate and assume the characteristics prevalent in the dominant mainstream society. Therefore, ethnic retention (i.e., immigrant families embracing their own ethnic

  6. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    DEFF Research Database (Denmark)

    Chornokur, Ganna; Lin, Hui-Yi; Tyrer, Jonathan P

    2015-01-01

    . As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. METHODS: In total, DNA samples were obtained from 14,525 case subjects with invasive EOC......BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes...... and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted...

  7. ¿Puede amortiguar el Engagement los efectos nocivos de la Procrastinación Académica?

    Directory of Open Access Journals (Sweden)

    Marcela Paz González-Brignardello

    2013-06-01

    Full Text Available El propósito de este estudio es explorar la relación existente entre la Procrastinación Académica y el Engagement, así como el patrón de funcionamiento de ambas variables en entornos académicos, en relación al uso de estrategias de aprendizaje autorregulado, eficientes y deficientes, y el estado de los estudiantes previo a la realización de los exámenes. Todas las variables han sido medidas a través de cuestionarios de autoinforme, en una población de universitarios en modalidad a distancia/en línea. Asimismo, se postula un posible efecto de amortiguación o buffering del Engagement sobre los efectos nocivos de la Procrastinación Académica. Este patrón diferencial se analiza con mayor precisión mediante la consideración de tres perfiles de estudiantes, los caracterizados por Engagement puro, los caracterizados por Procrastinación Académica pura, y un perfil mixto de procrastinadores con niveles de Engagement medio-alto. Los resultados obtenidos corroboran, por un lado, las grandes diferencias existentes en la forma de afrontar los estudios entre los estudiantes engaged y los procrastinadores y, por otro, el claro efecto amortiguador del engagement sobre la Procrastinación Académica, observándose en el perfil mixto una mejora significativa de carácter positivo, tanto en el tipo de estrategias de aprendizaje autorregulado utilizadas, como en su estado previo a los exámenes.

  8. The Ser311Cys variation in the paraoxonase 2 gene increases the ...

    Indian Academy of Sciences (India)

    Supplementary data: The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese. Yanchun Qu, Ze Yang, Feng Jin, Liang Sun, Chuanfang Zhang, Linong Ji, Hong Sun, Binyou Wang and Li Wang. J. Genet. 87, 165–169. Table 1. Clinical characteristics of case and control.

  9. Estratégias acadêmicas e suas manifestações: o discurso e a prática

    Directory of Open Access Journals (Sweden)

    Haroldo Andriguetto Junior

    2011-06-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2011v4n3p126   O objetivo deste artigo é analisar as estratégias acadêmicas e sua prática, examinando a realidade de uma universidade comunitária em Santa Catarina. O estudo está fundamentado nos trabalhos de Baldridge, Cohen e March, Weick, Keller, Hardy, Langley, Mintzberg e Rose, Hardy e Fachin, Birnbaum, Mintzberg e Meyer Jr., que destacam diversos fatores que fazem das universidades organizações complexas, atípicas e com implicações em seu gerenciamento. Trata-se de um estudo de caso que teve como foco de análise estratégias acadêmicas relevantes no período de 2001-2008. Os dados foram coletados junto às seguintes fontes: dados organizacionais, observações não participantes e entrevistas com base em narrativas com cinco gestores. A análise revela a presença de estratégias acadêmicas emanadas da administração superior do tipo “guarda-chuva”. As principais estratégias acadêmicas, de natureza emergente, surgem por iniciativas individuais e de pequenos grupos com a influência de aspectos racionais, políticos e simbólicos. As mais destacadas conclusões apontam para um discurso da administração superior centrado na racionalidade da gestão, privilegiando modelos empresariais incompatíveis com a realidade complexa da universidade. Revelou-se uma gestão acadêmica amadora, incremental e promotora de iniciativas estratégicas emergentes, com resultados significativos para o desempenho dos programas acadêmicos e da instituição.

  10. Mulher, maternidade e trabalho acadê Mujer, maternidad y trabajo académico Women, maternity and academic work

    Directory of Open Access Journals (Sweden)

    Márcia Regina Cangiani Fabbro

    2010-07-01

    Full Text Available Objetivo. Descrever a vivência do trabalho acadêmico e da maternidade das professoras universitárias. Metodologia. A investigação se realizou de dezembro de 2003 a dezembro de 2005 e se coletou informação das histórias de vida e das entrevistas reflexivas a cinco professoras de uma universidade pública de São Paulo (Brasil. Resultados. A análise dos dados compreendeu dois eixos: a história de cada "uma" e a história de todas "elas", que levou às categorias empíricas: maternidade, relações de gênero e trabalho acadêmico. Os resultados assinalaram que o trabalho proporciona a realização profissional, ao afirmarse como profissional e ao poder prover a manutenção da família, mas essa afirmação poderia ser secundária ao universo familiar e relacional que apóia as realizações individuais. Conclusão. A maternidade foi o elemento desencadeador de questionamentos do caráter mítico de mulher "realizada", o que levou a reflexionar sobre si mesmas, o trabalho e sua relação com os filhos e esposo.Objetivo. Describir la vivencia del trabajo académico y de la maternidad de las profesoras universitarias. Metodología. La investigación se realizó de diciembre de 2003 a diciembre de 2005 y se recolectó información de las historias de vida y de las entrevistas reflexivas a cinco profesoras de una universidad pública de São Paulo (Brasil. Resultados. El análisis de los datos comprendió dos ejes: la historia de "cada una" y la historia de "todas ellas", que llevó a las categorías empíricas: maternidad, relaciones de género y trabajo académico. Los resultados señalaron que el trabajo proporciona la realización profesional, al afirmarse como profesional y al poder proveer la manutención de la familia, pero esa afirmación podría ser secundaria al universo familiar y relacional que apoya las realizaciones individuales. Conclusión. La maternidad fue el elemento desencadenador de cuestionamientos del carácter m

  11. Factores relacionados con el rendimiento académico en alumnos de fisiopatología

    OpenAIRE

    Sanguinetti, José María; López, Raquel; Vieta, María Eugenia; Berruezo, Silvana; Chagra, Carolina

    2013-01-01

    Introducción: El rendimiento académico está relacionado con diferentes variables. Objetivos: Evaluar factores sociales, demográficos y hábitos, así como determinar su relación con el rendimiento académico. Material y métodos: Trabajo observacional, transversal, correlacional entre abril y noviembre de 2012. Se realizó una encuesta a alumnos de Fisiopatología, de la Universidad Nacional de Salta y se constató en noviembre quienes habían regularizado la asignatura. Variables estudiadas: edad, s...

  12. (Re)pensando a citação em textos acadêmico-científicos

    OpenAIRE

    Bessa, José Cezinaldo Rocha; Prof. Assistente II do Departamento de Letras, do Campus Avançado “Profª. Maria Elisa de Albuquerque Maia”, da universidade do Estado do Rio Grande do Norte, Pau dos Ferros, RN.

    2011-01-01

    Este trabalho tem como objetivo discutir sobre a citação no texto acadêmico-científico. Argumentamos em favor da necessidade de se reivindicar o citar em sua dimensão dialógica, partindo do pressuposto de que o olhar concebido pelos manuais de metodologia científica não dá conta da complexidade que recobre o citar no texto acadêmico-científico. Apoiando-nos em pressupostos teóricos do dialogismo bakhtiniano e em estudos de Maingueneau (1996, 2002), Charaudeau; Maingueneau (2004), Boch; Grossm...

  13. Culturas académicas: entre reinvención y contrabando

    Directory of Open Access Journals (Sweden)

    Kathya Araujo

    2015-03-01

    Full Text Available Sobre la base del análisis de una historia personal de desplazamiento entre academias (peruana y chilena, y la reinvención y el contrabando que toda migración supone, este artículo argumenta de qué manera frente a las nuevas modalidades de evaluación (los rankings, la búsqueda de isomorfismo de las estructuras argumentativas y las formas lingüísticas o incluso la ficción de sociologías globales, se mantienen vivas culturas académicas particulares. En este marco, la reflexión se organiza mostrando que detrás de la singularidad de los estilos intelectuales, formas de sociabilidad profesionales e incluso formas lingüísticas de cada una de ellas, lo que se revela es la manera como cada cultura académica local responde desde tradiciones diversas a desafíos político sociales distintos y con ello su rol de compromiso público y crítico.

  14. Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups.

    Science.gov (United States)

    Ali, Shafat; Chopra, Rupali; Manvati, Siddharth; Singh, Yoginder Pal; Kaul, Nabodita; Behura, Anita; Mahajan, Ankit; Sehajpal, Prabodh; Gupta, Subash; Dhar, Manoj K; Chainy, Gagan B N; Bhanwer, Amarjit S; Sharma, Swarkar; Bamezai, Rameshwar N K

    2013-01-01

    Type 2 diabetes (T2D) is a syndrome of multiple metabolic disorders and is genetically heterogeneous. India comprises one of the largest global populations with highest number of reported type 2 diabetes cases. However, limited information about T2D associated loci is available for Indian populations. It is, therefore, pertinent to evaluate the previously associated candidates as well as identify novel genetic variations in Indian populations to understand the extent of genetic heterogeneity. We chose to do a cost effective high-throughput mass-array genotyping and studied the candidate gene variations associated with T2D in literature. In this case-control candidate genes association study, 91 SNPs from 55 candidate genes have been analyzed in three geographically independent population groups from India. We report the genetic variants in five candidate genes: TCF7L2, HHEX, ENPP1, IDE and FTO, are significantly associated (after Bonferroni correction, ppopulation. Interestingly, SNP rs7903146 of the TCF7L2 gene passed the genome wide significance threshold (combined P value = 2.05E-08) in the studied populations. We also observed the association of rs7903146 with blood glucose (fasting and postprandial) levels, supporting the role of TCF7L2 gene in blood glucose homeostasis. Further, we noted that the moderate risk provided by the independently associated loci in combined population with Odds Ratio (OR)<1.38 increased to OR = 2.44, (95%CI = 1.67-3.59) when the risk providing genotypes of TCF7L2, HHEX, ENPP1 and FTO genes were combined, suggesting the importance of gene-gene interactions evaluation in complex disorders like T2D.

  15. Conducta prosocial y autoatribuciones académicas en Educación Secundaria Obligatoria

    Directory of Open Access Journals (Sweden)

    Jesús Redondo

    2014-05-01

    Full Text Available Este estudio presenta los resultados sobre la relación que existe entre las autoatribuciones académicas en lenguaje y matemáticas en una muestra de 2.022 estudiantes de Educación Secundaria de 12 a 16 años. Los adolescentes fueron seleccionados aleatoriamente de 20 escuelas urbanas y rurales en las provincias de Alicante y Murcia, España. La conducta prosocial fue codificada con el Teenage Inventory of Social Skills y las autoatribuciones académicas fueron medidas mediante la Escala de Atribución Causal de Sydney (Sydney Attribution Scale, SAS; Marsh, 1984. El 17.35% de estudiantes de ESO fueron identificados como prosociales. Los chicos de 2º de ESO y las chicas de 4º de ESO presentaron la menor y mayor prevalencia puntual de conducta prosocial, respectivamente. Respecto a la asignatura de lenguaje, los estudiantes prosociales atribuyen significativamente el éxito a la capacidad, el esfuerzo y, en menor medida, a causas externas. En cuanto a la asignatura de matemáticas, los estudiantes prosociales atribuyeron el éxito significativamente más al esfuerzo y significativamente menos a causas externas, mientras que atribuyeron el fracaso significativamente más a la falta de esfuerzo. Además, los datos han permitido crear un modelo de regresión logística que permite hacer estimaciones correctas respecto a la probabilidad de éxito académico en matemáticas, en lenguaje y en todas las asignaturas aprobadas en estudiantes prosociales de E.S.O. a partir de las puntuaciones en atribuciones académicas.

  16. Distinguishing the rates of gene activation from phenotypic variations.

    Science.gov (United States)

    Chen, Ye; Lv, Cheng; Li, Fangting; Li, Tiejun

    2015-06-18

    Stochastic genetic switching driven by intrinsic noise is an important process in gene expression. When the rates of gene activation/inactivation are relatively slow, fast, or medium compared with the synthesis/degradation rates of mRNAs and proteins, the variability of protein and mRNA levels may exhibit very different dynamical patterns. It is desirable to provide a systematic approach to identify their key dynamical features in different regimes, aiming at distinguishing which regime a considered gene regulatory network is in from their phenotypic variations. We studied a gene expression model with positive feedbacks when genetic switching rates vary over a wide range. With the goal of providing a method to distinguish the regime of the switching rates, we first focus on understanding the essential dynamics of gene expression system in different cases. In the regime of slow switching rates, we found that the effective dynamics can be reduced to independent evolutions on two separate layers corresponding to gene activation and inactivation states, and the transitions between two layers are rare events, after which the system goes mainly along deterministic ODE trajectories on a particular layer to reach new steady states. The energy landscape in this regime can be well approximated by using Gaussian mixture model. In the regime of intermediate switching rates, we analyzed the mean switching time to investigate the stability of the system in different parameter ranges. We also discussed the case of fast switching rates from the viewpoint of transition state theory. Based on the obtained results, we made a proposal to distinguish these three regimes in a simulation experiment. We identified the intermediate regime from the fact that the strength of cellular memory is lower than the other two cases, and the fast and slow regimes can be distinguished by their different perturbation-response behavior with respect to the switching rates perturbations. We proposed a

  17. Estudio del estrés, engagement y rendimiento académico en estudiantes universitarios de Ciencias de la Salud

    OpenAIRE

    Casuso Holgado, María Jesús

    2011-01-01

    En el estudio que hemos llevado a cabo se pretende conocer el estrés académico percibido por los estudiantes universitarios así como la implicación de éstos en sus estudios (engagement académico). De igual forma, se busca analizar la posible influencia de ambos aspectos en el rendimiento académico. Finalmente se estudiarán de forma comparada estos aspectos en las distintas modalidades de enseñanza-aprendizaje que coexisten en la actualidad (titulaciones en pilotaje de EEES, titulaciones sin...

  18. Association of variation in Fc gamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples

    NARCIS (Netherlands)

    McKinney, Cushla; Fanciulli, Manuela; Merriman, Marilyn E.; Phipps-Green, Amanda; Alizadeh, Behrooz Z.; Koeleman, Bobby P. C.; Dalbeth, Nicola; Gow, Peter J.; Harrison, Andrew A.; Highton, John; Jones, Peter B.; Stamp, Lisa K.; Steer, Sophia; Barrera, Pilar; Coenen, Marieke J. H.; Franke, Barbara; van Riel, Piet L. C. M.; Vyse, Tim J.; Aitman, Tim J.; Radstake, Timothy R. D. J.; Merriman, Tony R.

    2010-01-01

    Objective There is increasing evidence that variation in gene copy number (CN) influences clinical phenotype. The low-affinity Fc gamma receptor 3B (FCGR3B) located in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment to sites of inflammation and activation of

  19. Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

    DEFF Research Database (Denmark)

    Campa, Daniele; McKay, James; Sinilnikova, Olga

    2009-01-01

    and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases....... Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall...

  20. A Patient with Complex I Deficiency Caused by a Novel ACAD9 Mutation Not Responding to Riboflavin Treatment

    DEFF Research Database (Denmark)

    Nouws, Jessica; Wibrand, Flemming; van den Brand, Mariël

    2014-01-01

    fibroblasts partially rescued the complex I deficiency. Riboflavin supplementation did not ameliorate the complex I deficiency in patient fibroblasts. More than a dozen ACAD9 patients with complex I deficiency have been identified in the last 3 years, indicating that ACAD9 is important for complex I assembly...

  1. Application of heteroduplex analysis for detecting variation within the growth hormone 2 gene in Salmo trutta L. (brown trout).

    Science.gov (United States)

    Gross, R; Nilsson, J

    1995-03-01

    A new method to detect variation at a single copy nuclear gene in brown trout, Salmo trutta L., is provided. The technique entails (i) selective gene amplification by the polymerase chain reaction (PCR), (ii) digestion of amplification products by restriction endonucleases to obtain fragments of suitable size, (iii) hybridization with heterologous DNA followed by denaturation and reannealing to obtain heteroduplex molecules, and (iv) screening for variation in polyacrylamide gels. Variation was studied within a growth hormone 2 gene 1489 bp segment and polymorphism was detected in two HinfI-digested fragments. Formation of different heteroduplex patterns in experimental mixtures of digested amplification products from brown trout and Atlantic salmon, Salmo salar L., allowed us to determine the genotype of the brown trout. Polymorphism was observed in four out of six studied populations.

  2. Geographic Variation in Advertisement Calls in a Tree Frog Species: Gene Flow and Selection Hypotheses

    Science.gov (United States)

    Jang, Yikweon; Hahm, Eun Hye; Lee, Hyun-Jung; Park, Soyeon; Won, Yong-Jin; Choe, Jae C.

    2011-01-01

    Background In a species with a large distribution relative to its dispersal capacity, geographic variation in traits may be explained by gene flow, selection, or the combined effects of both. Studies of genetic diversity using neutral molecular markers show that patterns of isolation by distance (IBD) or barrier effect may be evident for geographic variation at the molecular level in amphibian species. However, selective factors such as habitat, predator, or interspecific interactions may be critical for geographic variation in sexual traits. We studied geographic variation in advertisement calls in the tree frog Hyla japonica to understand patterns of variation in these traits across Korea and provide clues about the underlying forces for variation. Methodology We recorded calls of H. japonica in three breeding seasons from 17 localities including localities in remote Jeju Island. Call characters analyzed were note repetition rate (NRR), note duration (ND), and dominant frequency (DF), along with snout-to-vent length. Results The findings of a barrier effect on DF and a longitudinal variation in NRR seemed to suggest that an open sea between the mainland and Jeju Island and mountain ranges dominated by the north-south Taebaek Mountains were related to geographic variation in call characters. Furthermore, there was a pattern of IBD in mitochondrial DNA sequences. However, no comparable pattern of IBD was found between geographic distance and call characters. We also failed to detect any effects of habitat or interspecific interaction on call characters. Conclusions Geographic variations in call characters as well as mitochondrial DNA sequences were largely stratified by geographic factors such as distance and barriers in Korean populations of H. japoinca. Although we did not detect effects of habitat or interspecific interaction, some other selective factors such as sexual selection might still be operating on call characters in conjunction with restricted gene

  3. Las herramientas 2.0 en la escritura académica: buscadores y diccionarios

    Directory of Open Access Journals (Sweden)

    Montserrat Casanovas Catalá

    2015-11-01

    Full Text Available En este artículo se exponen algunos de los resultados de un estudio sobre el uso de las tecnologías de la información y la comunicación (TIC en la escritura académica que está llevando a cabo el Grupo de Investigación en Mediación Lingü.stica (giml de la Universidad de Lleida. Dicho estudio pretende mostrar cómo se integran herramientas como los diccionarios en línea o los buscadores en el proceso de elaboración de textos académicos por parte de estudiantes universitarios.

  4. Autoestima y rendimiento académico: un estado de la cuestión

    OpenAIRE

    Rodríguez-Martín, Rosa

    2014-01-01

    En este trabajo se hace una revisión bibliográfica profunda para explicar la relación entre autoestima y rendimiento académico en Educación Primaria. Según los autores consultados, es la familia la que inicia a los niños en la construcción de su autoestima, y más tarde la escuela, a través de la enseñanza, puede moldearla obteniendo una autoestima sana que le haga aumentar el rendimiento académico en Educación Primaria. Una autoestima positiva hará que el alumno no cese en el intento de...

  5. As ferramentas 2.0 na escritura acadêmica: buscadores e dicionários

    OpenAIRE

    Casanovas Catalá, Montserrat

    2016-01-01

    En este artículo se exponen algunos de los resultados de un estudio sobre el uso de las tecnologías de la información y la comunicación (TIC) en la escritura académica que está llevando a cabo el Grupo de Investigación en Mediación Lingüística (GIML) de la Universidad de Lleida. Dicho estudio pretende mostrar cómo se integran herramientas como los diccionarios en línea o los buscadores en el proceso de elaboración de textos académicos por parte de estudiantes universitarios. This article p...

  6. El liderazgo académico, comunicación asertiva y motivación

    OpenAIRE

    Ugalde Villalobos, María Eugenia; Canales García, Alba

    2017-01-01

    Este ensayo   destaca que el liderazgo es importante para mejorar el rendimiento académico, despertar el entusiasmo, la motivación, la comunicación asertiva   y favorecer el trabajo en equipo, el cual lo forman docentes, estudiantes y la dirección. Además, se define cómo se ejerce el liderazgo actualmente, por qué es importante,  cuál es su relación con el contexto educativo y cómo se relacionan la comunicación asertiva, la escucha y la motivación con el liderazgo académico, elementos importa...

  7. Allelic variation of the FRMD7 gene in congenital idiopathic nystagmus.

    Science.gov (United States)

    Self, James E; Shawkat, Fatima; Malpas, Crispin T; Thomas, N Simon; Harris, Christopher M; Hodgkins, Peter R; Chen, Xiaoli; Trump, Dorothy; Lotery, Andrew J

    2007-09-01

    To perform a genotype-phenotype correlation study in an X-linked congenital idiopathic nystagmus pedigree (pedigree 1) and to assess the allelic variance of the FRMD7 gene in congenital idiopathic nystagmus. Subjects from pedigree 1 underwent detailed clinical examination including nystagmology. Screening of FRMD7 was undertaken in pedigree 1 and in 37 other congenital idiopathic nystagmus probands and controls. Direct sequencing confirmed sequence changes. X-inactivation studies were performed in pedigree 1. The nystagmus phenotype was extremely variable in pedigree 1. We identified 2 FRMD7 mutations. However, 80% of X-linked families and 96% of simplex cases showed no mutations. X-inactivation studies demonstrated no clear causal link between skewing and variable penetrance. We confirm profound phenotypic variation in X-linked congenital idiopathic nystagmus pedigrees. We demonstrate that other congenital nystagmus genes exist besides FRMD7. We show that the role of X inactivation in variable penetrance is unclear in congenital idiopathic nystagmus. Clinical Relevance We demonstrate that phenotypic variation of nystagmus occurs in families with FRMD7 mutations. While FRMD7 mutations may be found in some cases of X-linked congenital idiopathic nystagmus, the diagnostic yield is low. X-inactivation assays are unhelpful as a test for carrier status for this disease.

  8. Implementación de la carrera académica como medio de integración del NSPT a la Universidad

    Directory of Open Access Journals (Sweden)

    Noemi Susana Geromini

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2013v6n4p92   Con el fin de mejorar la calidad académica de su cuerpo docente, el Instituto Nacional Superior del Profesorado Técnico -INSPT-, como Institución de Educación Superior  no Universitaria, considera necesaria la planificación de estrategias que permitan generar espacios de pertenencia a sus docentes, que les otorguen estabilidad laboral y posibilidades de proyección, mediante el establecimiento de reglas claras e imparciales que protejan a la comunidad académica. La calidad académica se logra por medio de una clara definición de las características esperadas de los docentes y la excelencia se fomenta con procesos de evaluación continuos de todas las activida-des de la vida académica: enseñanza, investigación, extensión y gestión. La Carrera Académica, sistema que establece ingreso, permanencia y promoción de los docentes, resulta ser el recurso más adecuado para estimular la mejora continua de la tarea docente y lograr la excelencia académica, haciendo posible la integración de una institución no universitaria al sistema universitario. Mediante un exhaustivo análisis de la idiosincrasia de la comunidad educativa del INSPT, y aten-diendo a las características esperables de sus docentes, el Instituto procura adaptarse al régimen docente universitario vigente en la Universidad Tecnológica Nacional  -UTN. Para lograr este objetivo, se han analizado el Estatuto Universitario, la Ordenanza 1182 del Consejo Superior y se ha elaborado un documento que, por un lado, fundamenta la necesidad de adecuar el régimen de ingreso, permanencia y promoción docente del INSPT a la Carrera Académica de la Universidad, y por otro, propone los pasos a seguir para su implementación, con el convencimiento de que su aplicación redundará en una continua mejora de la calidad académica del Instituto. El presente trabajo tiene como objetivos, por un lado, fundamentar y describir el proceso de

  9. El plagio y su relación con los procesos de escritura académica

    Directory of Open Access Journals (Sweden)

    Ligia Ochoa S.

    2014-01-01

    Full Text Available El plagio es un fenómeno que preocupa a la comunidad académica. Diversos factores explican las causas de este problema, pero uno de los más destacados se relaciona con los procesos de escritura académica. En este artículo se presentan los resultados de la investigación desarrollada sobre este factor, obtenidos a partir de entrevistas a profesores y estudiantes de la Facultad de Ciencias Humanas de la Universidad Nacional de Colombia. Según los docentes, el problema del plagio en la escritura se debe a la mala formación del estudiante y a los hábitos cultivados en el colegio, en donde no se enseña a citar. Los estudiantes consideran que se incurre en el plagio porque tienen problemas de escritura y porque no han recibido una formación adecuada para producir textos académicos.

  10. Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities

    Science.gov (United States)

    Wu, X; Offenbacher, S; Lόpez, N J; Chen, D; Wang, H-Y; Rogus, J; Zhou, J; Beck, J; Jiang, S; Bao, X; Wilkins, L; Doucette-Stamm, L; Kornman, K

    2015-01-01

    Background and Objective Genetic markers associated with disease are often non-functional and generally tag one or more functional “causative” variants in linkage disequilibrium. Markers may not show tight linkage to the causative variants across multiple ethnicities due to evolutionary divergence, and therefore may not be informative across different population groups. Validated markers of disease suggest causative variants exist in the gene and, if the causative variants can be identified, it is reasonable to hypothesize that such variants will be informative across diverse populations. The aim of this study was to test that hypothesis using functional Interleukin-1 (IL-1) gene variations across multiple ethnic populations to replace the non-functional markers originally associated with chronic adult periodontitis in Caucasians. Material and Methods Adult chronic periodontitis cases and controls from four ethnic groups (Caucasians, African Americans, Hispanics and Asians) were recruited in the USA, Chile and China. Genotypes of IL1B gene single nucleotide polymorphisms (SNPs), including three functional SNPs (rs16944, rs1143623, rs4848306) in the promoter and one intronic SNP (rs1143633), were determined using a single base extension method or TaqMan 5′ nuclease assay. Logistic regression and other statistical analyses were used to examine the association between moderate to severe periodontitis and IL1B gene variations, including SNPs, haplotypes and composite genotypes. Genotype patterns associated with disease in the discovery study were then evaluated in independent validation studies. Results Significant associations were identified in the discovery study, consisting of Caucasians and African Americans, between moderate to severe adult chronic periodontitis and functional variations in the IL1B gene, including a pattern of four IL1B SNPs (OR = 1.87, p < 0.0001). The association between the disease and this IL1B composite genotype pattern was validated

  11. The Orphan Gene dauerless Regulates Dauer Development and Intraspecific Competition in Nematodes by Copy Number Variation.

    Directory of Open Access Journals (Sweden)

    Melanie G Mayer

    2015-06-01

    Full Text Available Many nematodes form dauer larvae when exposed to unfavorable conditions, representing an example of phenotypic plasticity and a major survival and dispersal strategy. In Caenorhabditis elegans, the regulation of dauer induction is a model for pheromone, insulin, and steroid-hormone signaling. Recent studies in Pristionchus pacificus revealed substantial natural variation in various aspects of dauer development, i.e. pheromone production and sensing and dauer longevity and fitness. One intriguing example is a strain from Ohio, having extremely long-lived dauers associated with very high fitness and often forming the most dauers in response to other strains' pheromones, including the reference strain from California. While such examples have been suggested to represent intraspecific competition among strains, the molecular mechanisms underlying these dauer-associated patterns are currently unknown. We generated recombinant-inbred-lines between the Californian and Ohioan strains and used quantitative-trait-loci analysis to investigate the molecular mechanism determining natural variation in dauer development. Surprisingly, we discovered that the orphan gene dauerless controls dauer formation by copy number variation. The Ohioan strain has one dauerless copy causing high dauer formation, whereas the Californian strain has two copies, resulting in strongly reduced dauer formation. Transgenic animals expressing multiple copies do not form dauers. dauerless is exclusively expressed in CAN neurons, and both CAN ablation and dauerless mutations increase dauer formation. Strikingly, dauerless underwent several duplications and acts in parallel or downstream of steroid-hormone signaling but upstream of the nuclear-hormone-receptor daf-12. We identified the novel or fast-evolving gene dauerless as inhibitor of dauer development. Our findings reveal the importance of gene duplications and copy number variations for orphan gene function and suggest daf-12 as

  12. Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups.

    Directory of Open Access Journals (Sweden)

    Shafat Ali

    Full Text Available Type 2 diabetes (T2D is a syndrome of multiple metabolic disorders and is genetically heterogeneous. India comprises one of the largest global populations with highest number of reported type 2 diabetes cases. However, limited information about T2D associated loci is available for Indian populations. It is, therefore, pertinent to evaluate the previously associated candidates as well as identify novel genetic variations in Indian populations to understand the extent of genetic heterogeneity. We chose to do a cost effective high-throughput mass-array genotyping and studied the candidate gene variations associated with T2D in literature. In this case-control candidate genes association study, 91 SNPs from 55 candidate genes have been analyzed in three geographically independent population groups from India. We report the genetic variants in five candidate genes: TCF7L2, HHEX, ENPP1, IDE and FTO, are significantly associated (after Bonferroni correction, p<5.5E-04 with T2D susceptibility in combined population. Interestingly, SNP rs7903146 of the TCF7L2 gene passed the genome wide significance threshold (combined P value = 2.05E-08 in the studied populations. We also observed the association of rs7903146 with blood glucose (fasting and postprandial levels, supporting the role of TCF7L2 gene in blood glucose homeostasis. Further, we noted that the moderate risk provided by the independently associated loci in combined population with Odds Ratio (OR<1.38 increased to OR = 2.44, (95%CI = 1.67-3.59 when the risk providing genotypes of TCF7L2, HHEX, ENPP1 and FTO genes were combined, suggesting the importance of gene-gene interactions evaluation in complex disorders like T2D.

  13. Plagio académico en el alumnado académico de máster en la universidad de Alicante

    OpenAIRE

    Ronda-Pérez, Elena; Seguí-Crespo, Mar; Cayuela, Ana; Tauste Francés, Ana; Esteve-Faubel, José-María

    2016-01-01

    Resulta cada vez más evidente que el plagio académico se ha convertido en un grave problema para las universidades. Tanto en la investigación como en el proceso de enseñanza-aprendizaje se debe asegurar que la comunidad universitaria actúa con honestidad, responsabilidad, justicia y trasparencia, y el plagio va en contra de todos estos principios. Son muy escasos los estudios que el contexto universitario español han abordado este tema en alumnos de master. El objetivo de este estudio es esti...

  14. Prácticas de lectura y escritura académicas en la universidad colombiana

    OpenAIRE

    Graciela Uribe-Álvarez; Zahyra Camargo-Martínez

    2011-01-01

    Este artículo de revisión presenta el análisis de algunas prácticas de lectura y escritura académicas en la universidad colombiana, conocidas por diversos medios (bases de datos, memorias en páginas web y en cd-rom de congresos, coloquios, encuentros y seminarios). Pretende aportar a la reflexión y el diálogo académico entre profesionales de la educación, a partir de experiencias en campos problemáticos específicos. Los resultados se sustentan en el análisis de 40 trabajos de investigación (a...

  15. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.

    Science.gov (United States)

    Glessner, Joseph T; Wang, Kai; Cai, Guiqing; Korvatska, Olena; Kim, Cecilia E; Wood, Shawn; Zhang, Haitao; Estes, Annette; Brune, Camille W; Bradfield, Jonathan P; Imielinski, Marcin; Frackelton, Edward C; Reichert, Jennifer; Crawford, Emily L; Munson, Jeffrey; Sleiman, Patrick M A; Chiavacci, Rosetta; Annaiah, Kiran; Thomas, Kelly; Hou, Cuiping; Glaberson, Wendy; Flory, James; Otieno, Frederick; Garris, Maria; Soorya, Latha; Klei, Lambertus; Piven, Joseph; Meyer, Kacie J; Anagnostou, Evdokia; Sakurai, Takeshi; Game, Rachel M; Rudd, Danielle S; Zurawiecki, Danielle; McDougle, Christopher J; Davis, Lea K; Miller, Judith; Posey, David J; Michaels, Shana; Kolevzon, Alexander; Silverman, Jeremy M; Bernier, Raphael; Levy, Susan E; Schultz, Robert T; Dawson, Geraldine; Owley, Thomas; McMahon, William M; Wassink, Thomas H; Sweeney, John A; Nurnberger, John I; Coon, Hilary; Sutcliffe, James S; Minshew, Nancy J; Grant, Struan F A; Bucan, Maja; Cook, Edwin H; Buxbaum, Joseph D; Devlin, Bernie; Schellenberg, Gerard D; Hakonarson, Hakon

    2009-05-28

    Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies focusing on candidate genes or genomic regions have identified several copy number variations (CNVs) that are associated with an increased risk of ASDs. Here we present the results from a whole-genome CNV study on a cohort of 859 ASD cases and 1,409 healthy children of European ancestry who were genotyped with approximately 550,000 single nucleotide polymorphism markers, in an attempt to comprehensively identify CNVs conferring susceptibility to ASDs. Positive findings were evaluated in an independent cohort of 1,336 ASD cases and 1,110 controls of European ancestry. Besides previously reported ASD candidate genes, such as NRXN1 (ref. 10) and CNTN4 (refs 11, 12), several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls (P = 9.5 x 10(-3)). Furthermore, CNVs within or surrounding genes involved in the ubiquitin pathways, including UBE3A, PARK2, RFWD2 and FBXO40, were affected by CNVs not observed in controls (P = 3.3 x 10(-3)). We also identified duplications 55 kilobases upstream of complementary DNA AK123120 (P = 3.6 x 10(-6)). Although these variants may be individually rare, they target genes involved in neuronal cell-adhesion or ubiquitin degradation, indicating that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.

  16. Roles of putative sodium-hydrogen antiporter (SHA) genes in S. coelicolor A3(2) culture with pH variation.

    Science.gov (United States)

    Kim, Yoon Jung; Moon, Myung Hee; Lee, Jae Sun; Hong, Soon-Kwang; Chang, Yong Keun

    2011-09-01

    Culture pH change has some important roles in signal transduction and secondary metabolism. We have already reported that acidic pH shock enhanced actinorhodin production in Streptomyces coelicolor. Among many potential governing factors on pH variation, the putative Na(+)/H(+) antiporter (sha) genes in S. coelicolor have been investigated in this study to elucidate the association of the sha on pH variation and secondary metabolism. Through the transcriptional analysis and overexpression experiments on 8 sha genes, we observed that most of the sha expressions were promoted by pH shock, and in the opposite way the pH changes and actinorhodin production were enhanced by the overexpression of each sha. We also confirmed that sha8 especially has a main role in maintaining cell viability and pH homeostasis through Na(+) extrusion, in salt effect experiment under the alkaline medium condition by deleting sha8. Moreover, this gene was observed to have a function of pH recovery after pH variation such as the pH shock, being able to cause the sporulation. However, actinorhodin production was not induced by the only pH recovery. The sha8 gene could confer on the host cell the ability to recover pH to the neutral level after pH variation like a pH drop. Sporulation was closely associated with this pH recovery caused by the action of sha8, whereas actinorhodin production was not due to such pH variation patterns alone.

  17. Nosotros los académicos. Narrativas identitarias y autodefinición en la universidad actual

    OpenAIRE

    Fardella Cisternas, Carla; Pontificia Universidad Católica de Valparaíso; Sisto Campos, Vicente; Pontificia Universidad Católica de Valparaíso; Jiménez Vargas, Felipe; Pontificia Universidad Católica de Valparaíso

    2016-01-01

    Las transformaciones del espacio universitario a partir de los años ochenta, en Chile, revelan el ascenso de formas managerialistas de organizar la universidad y el trabajo académico. El nuevo managment, orientado por lógicas de eficiencia y mercado, promueve una cultura laboral de rendición de cuentas y, en consecuencia, una reconfiguración de las identidades académicas llamadas a adscribirse a este nuevo modelo de universidad. Este artículo presenta una investigación cualitativa realizada e...

  18. Factores asociados al fracaso académico en estudiantes universitarios de Barranquilla (Colombia

    Directory of Open Access Journals (Sweden)

    Katherine Contreras

    2008-01-01

    Full Text Available El fracaso académico es un problema que afrontan los estudiantes quepresentan un rendimiento académico deficiente, lo cual los lleva en pocotiempo a desertar o son expulsados del sistema educativo. Se considera que es un problema multicausal, pero para afrontarlo es necesario indagar desde los mismos estudiantes qué es lo que más los puede estar afectando.Para indagar sobre los factores asociados a este problema se llevó a cabo un estudio descriptivo con estudiantes de psicología en una universidad privada de Barranquilla (Colombia. Se entrevistó a 38 estudiantes que asistían a un programa exclusivo para aquellos con muy bajo rendimiento académico y que estaban en riesgo de salir del programa o habían sido remitidos por los profesores. Los resultados indican que los estudiantes no recibieron una orientación vocacional adecuada antes de ingresar a los estudios superiores que les permitiera analizar sus capacidades y habilidades con respecto a una carrera profesional. Además manifiestan limitaciones en sus competencias de concentración y atención, en la distribución del tiempo, en la deficiente utilización de técnicas de estudio, y en la poca asistencia a clases por la baja motivación en las actividades académicas. La relación con su familia la consideraron satisfactoria. Se observa que las acciones para reducir el fracaso deben ser emprendidas antes del ingreso a la universidad, con estrategias de estudio y afrontamiento que les brinden a los jóvenes las mejores opciones entre sus intereses y capacidades con las oportunidades que les ofrece la sociedad en la cual vivirán.

  19. Gene expression profiles deciphering rice phenotypic variation between Nipponbare (Japonica and 93-11 (Indica during oxidative stress.

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    Fengxia Liu

    Full Text Available Rice is a very important food staple that feeds more than half the world's population. Two major Asian cultivated rice (Oryza sativa L. subspecies, japonica and indica, show significant phenotypic variation in their stress responses. However, the molecular mechanisms underlying this phenotypic variation are still largely unknown. A common link among different stresses is that they produce an oxidative burst and result in an increase of reactive oxygen species (ROS. In this study, methyl viologen (MV as a ROS agent was applied to investigate the rice oxidative stress response. We observed that 93-11 (indica seedlings exhibited leaf senescence with severe lesions under MV treatment compared to Nipponbare (japonica. Whole-genome microarray experiments were conducted, and 1,062 probe sets were identified with gene expression level polymorphisms between the two rice cultivars in addition to differential expression under MV treatment, which were assigned as Core Intersectional Probesets (CIPs. These CIPs were analyzed by gene ontology (GO and highlighted with enrichment GO terms related to toxin and oxidative stress responses as well as other responses. These GO term-enriched genes of the CIPs include glutathine S-transferases (GSTs, P450, plant defense genes, and secondary metabolism related genes such as chalcone synthase (CHS. Further insertion/deletion (InDel and regulatory element analyses for these identified CIPs suggested that there may be some eQTL hotspots related to oxidative stress in the rice genome, such as GST genes encoded on chromosome 10. In addition, we identified a group of marker genes individuating the japonica and indica subspecies. In summary, we developed a new strategy combining biological experiments and data mining to study the possible molecular mechanism of phenotypic variation during oxidative stress between Nipponbare and 93-11. This study will aid in the analysis of the molecular basis of quantitative traits.

  20. Natural variation in rosette size under salt stress conditions corresponds to developmental differences between Arabidopsis accessions and allelic variation in the LRR-KISS gene

    KAUST Repository

    Julkowska, Magdalena

    2016-02-11

    Natural variation among Arabidopsis accessions is an important genetic resource to identify mechanisms underlying plant development and stress tolerance. To evaluate the natural variation in salinity stress tolerance, two large-scale experiments were performed on two populations consisting of 160 Arabidopsis accessions each. Multiple traits, including projected rosette area, and fresh and dry weight were collected as an estimate for salinity tolerance. Our results reveal a correlation between rosette size under salt stress conditions and developmental differences between the accessions grown in control conditions, suggesting that in general larger plants were more salt tolerant. This correlation was less pronounced when plants were grown under severe salt stress conditions. Subsequent genome wide association study (GWAS) revealed associations with novel candidate genes for salinity tolerance such as LRR-KISS (At4g08850), flowering locus KH-domain containing protein and a DUF1639-containing protein. Accessions with high LRR-KISS expression developed larger rosettes under salt stress conditions. Further characterization of allelic variation in candidate genes identified in this study will provide more insight into mechanisms of salt stress tolerance due to enhanced shoot growth.

  1. La cultura digital de los estudiantes universitarios en entornos académicos

    Directory of Open Access Journals (Sweden)

    Eucario Parra Castrillón

    2011-01-01

    Full Text Available La posibilidad de acceso a Internet determina diferencias, incomprensiones y marginalidades que trascienden hacia lo educativo. No obstante, la red está presente, su penetración ineludible define cierta extensión virtual. Estar excluido del ciberespacio demuestra marginalidad y al contrario, para quienes allí tienen hábitos de estudio las potencialidades académicas e investigativas les resultan significativas. Otro problema, además de la marginalidad, se relaciona con las diferencias entre los nativos digitales y los demás. Los hábitos, lenguajes y posiciones disjuntas determinan incomprensiones y juzgamientos apresurados. Es el caso de la cultura digital de los estudiantes universitarios, que determina formas de construcción académica no siempre acordes con la tradición de sus profesores.

  2. MHC class II genes in the European badger (Meles meles) : Characterization, patterns of variation, and transcription analysis

    NARCIS (Netherlands)

    Sin, Yung Wa; Dugdale, Hannah L.; Newman, Chris; Macdonald, David W.; Burke, Terry

    The major histocompatibility complex (MHC) comprises many genes, some of which are polymorphic with numerous alleles. Sequence variation among alleles is most pronounced in exon 2 of the class II genes, which encodes the alpha 1 and beta 1 domains that form the antigen-binding site (ABS) for the

  3. Sequence Variation in Toxoplasma gondii rop17 Gene among Strains from Different Hosts and Geographical Locations

    Directory of Open Access Journals (Sweden)

    Nian-Zhang Zhang

    2014-01-01

    Full Text Available Genetic diversity of T. gondii is a concern of many studies, due to the biological and epidemiological diversity of this parasite. The present study examined sequence variation in rhoptry protein 17 (ROP17 gene among T. gondii isolates from different hosts and geographical regions. The rop17 gene was amplified and sequenced from 10 T. gondii strains, and phylogenetic relationship among these T. gondii strains was reconstructed using maximum parsimony (MP, neighbor-joining (NJ, and maximum likelihood (ML analyses. The partial rop17 gene sequences were 1375 bp in length and A+T contents varied from 49.45% to 50.11% among all examined T. gondii strains. Sequence analysis identified 33 variable nucleotide positions (2.1%, 16 of which were identified as transitions. Phylogeny reconstruction based on rop17 gene data revealed two major clusters which could readily distinguish Type I and Type II strains. Analyses of sequence variations in nucleotides and amino acids among these strains revealed high ratio of nonsynonymous to synonymous polymorphisms (>1, indicating that rop17 shows signs of positive selection. This study demonstrated the existence of slightly high sequence variability in the rop17 gene sequences among T. gondii strains from different hosts and geographical regions, suggesting that rop17 gene may represent a new genetic marker for population genetic studies of T. gondii isolates.

  4. Evaluation of bovine chemerin (RARRES2 gene variation on beef cattle production traits

    Directory of Open Access Journals (Sweden)

    Amanda K Lindholm-Perry

    2012-03-01

    Full Text Available A previous study in cattle based on >48,000 markers identified markers on chromosome 4 near the chemerin gene associated with average daily feed intake (ADFI in steers (P<0.008. Chemerin is an adipokine associated with obesity and metabolic syndrome in humans, representing a strong candidate gene potentially underlying the observed association. To evaluate whether the bovine chemerin gene is involved in feed intake, 16 markers within and around the gene were tested for association in the same resource population. Eleven were nominally significant for ADFI (P<0.05 and two were significant after Bonferroni correction. Two and five SNP in this region were nominally significant for the related traits of average daily gain (ADG and residual feed intake (RFI, respectively. All markers were evaluated for effects on meat quality and carcass phenotypes. Many of the markers associated with ADFI were associated with hot carcass weight (HCW, adjusted fat thickness (AFT, and marbling (P<0.05. Marker alleles that were associated with lower ADFI were also associated with lower HCW, AFT, and marbling. Markers associated with ADFI were genotyped in a validation population of steers representing 14 breeds to determine predictive merit across populations. No consistent relationships for ADFI were detected. To determine whether cattle feed intake or growth phenotypes might be related to chemerin transcript abundance, the expression of chemerin was evaluated in adipose of 114 heifers that were siblings of the steers in the discovery population. Relative chemerin transcript abundance was not correlated with ADFI, ADG, or RFI, but associations with body condition score and yearling weight were observed. We conclude that variation in the chemerin gene may underlie observed association in the resource population, but that additional research is required to determine if this variation is widespread among breeds and to develop robust markers with predictive merit across

  5. Les variations diasystématiques et leurs interdépendances dans les langues romanes

    DEFF Research Database (Denmark)

    Le présent volume contient un choix des actes du Colloque DIA II sur la variation linguistique dans les langues romanes. Ce colloque organisé par l'Université de Copenhague en collaboration avec l’Académie Royale des Sciences et Belles-lettres du Danemark du 19 au 21 novembre 2012 était consacré ...

  6. Hábitos o comportamientos inadecuados y malos resultados académicos en estudiantes de secundaria

    OpenAIRE

    Aguilar Valdés, Juan; Cumbá Abreu, Caridad; Cortés Alfaro, Alba; Collado, Ana María; García Roche, René G; Pérez Sosa, Dania

    2010-01-01

    Determinados hábitos y comportamientos son más frecuentes en educandos con malos resultados académicos, por ser sus causas o consecuencias. El objetivo del actual trabajo fue identificar la relación entre los hábitos o comportamientos de vida inadecuados, con los malos resultados académicos de los alumnos de una secundaria básica del municipio Habana Vieja. Se realizó un estudio de tipo transversal, en los 1 129 alumnos de una Escuela Secundaria Básica del Municipio Habana Vieja en Ciudad de ...

  7. Estrés académico y funcionalidad familiar en estudiantes de odontología

    OpenAIRE

    Shyrley Díaz Cárdenas; Katherine Arrieta Vergara; Farith González Martínez

    2014-01-01

    Objetivo: Asociar estrés académico y funcionalidad familiar en estudiantes de odontología. Metodología: Estudio de corte transversal en una muestra probabilística de 251 estudiantes de odontología de una universidad pública de Cartagena de Indias (Colombia). Se midieron características sociodemográficas, estrés académico (escala SISCO) y funcionalidad familiar (APGAR familiar). Se estimó ocurrencia (prevalencias), asociación entre variables (odd ratios) y análisis multivariable (regresión log...

  8. The roles of Dmrt (Double sex/Male-abnormal-3 Related Transcription factor) genes in sex determination and differentiation mechanisms: Ubiquity and diversity across the animal kingdom.

    Science.gov (United States)

    Picard, Marion Anne-Lise; Cosseau, Céline; Mouahid, Gabriel; Duval, David; Grunau, Christoph; Toulza, Ève; Allienne, Jean-François; Boissier, Jérôme

    2015-07-01

    The Dmrt (Double sex/Male-abnormal-3 Related Transcription factor) genes have been intensively studied because they represent major transcription factors in the pathways governing sex determination and differentiation. These genes have been identified in animal groups ranging from cnidarians to mammals, and some of the genes functionally studied. Here, we propose to analyze (i) the presence/absence of various Dmrt gene groups in the different taxa across the animal kingdom; (ii) the relative expression levels of the Dmrt genes in each sex; (iii) the specific spatial (by organ) and temporal (by developmental stage) variations in gene expression. This review considers non-mammalian animals at all levels of study (i.e. no particular importance is given to animal models), and using all types of sexual strategy (hermaphroditic or gonochoric) and means of sex determination (i.e. genetic or environmental). To conclude this global comparison, we offer an analysis of the DM domains conserved among the different DMRT proteins, and propose a general sex-specific pattern for each member of the Dmrt gene family. Copyright © 2015 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  9. Natural selection in a population of Drosophila melanogaster explained by changes in gene expression caused by sequence variation in core promoter regions.

    Science.gov (United States)

    Sato, Mitsuhiko P; Makino, Takashi; Kawata, Masakado

    2016-02-09

    Understanding the evolutionary forces that influence variation in gene regulatory regions in natural populations is an important challenge for evolutionary biology because natural selection for such variations could promote adaptive phenotypic evolution. Recently, whole-genome sequence analyses have identified regulatory regions subject to natural selection. However, these studies could not identify the relationship between sequence variation in the detected regions and change in gene expression levels. We analyzed sequence variations in core promoter regions, which are critical regions for gene regulation in higher eukaryotes, in a natural population of Drosophila melanogaster, and identified core promoter sequence variations associated with differences in gene expression levels subjected to natural selection. Among the core promoter regions whose sequence variation could change transcription factor binding sites and explain differences in expression levels, three core promoter regions were detected as candidates associated with purifying selection or selective sweep and seven as candidates associated with balancing selection, excluding the possibility of linkage between these regions and core promoter regions. CHKov1, which confers resistance to the sigma virus and related insecticides, was identified as core promoter regions that has been subject to selective sweep, although it could not be denied that selection for variation in core promoter regions was due to linked single nucleotide polymorphisms in the regulatory region outside core promoter regions. Nucleotide changes in core promoter regions of CHKov1 caused the loss of two basal transcription factor binding sites and acquisition of one transcription factor binding site, resulting in decreased gene expression levels. Of nine core promoter regions regions associated with balancing selection, brat, and CG9044 are associated with neuromuscular junction development, and Nmda1 are associated with learning

  10. Influence of IL15 gene variations on the clinical features, treatment response and risk of developing childhood acute lymphoblastic leukemia in Latvian population.

    Science.gov (United States)

    Rots, Dmitrijs; Kreile, Madara; Nikulshin, Sergejs; Kovalova, Zhanna; Gailite, Linda

    2018-02-01

    Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Modern treatment protocols allow achievement of long-term event-free survival rates in up to 85% of cases, although the treatment response varies among different patient groups. It is hypothesized that treatment response is influenced by the IL15 gene variations, although research results are conflicting. To analyze IL15 gene variations influence treatment response, clinical course and the risk of developing ALL we performed a case-control and family-based study. The study included 81 patients with childhood ALL. DNA samples of both or one biological parent were available for 62 of ALL patients and 130 age and gender adjusted healthy samples were used as a control group. Analyzed IL15 gene variations: rs10519612, rs10519613 and rs17007695 were genotyped using PCR-RFLP assay. Our results shows that IL15 gene variations haplotypes are associated with the risk of developing childhood ALL (p variations separately. The variations rs10519612 and rs1059613 in a recessive pattern of inheritance were associated with hyperdiploidy (p = 0.048). Analyzed genetic variations had no impact on other clinical features and treatment response (assessed by the minimal residual disease) in our study.

  11. Vida académica de la facultad

    Directory of Open Access Journals (Sweden)

    Facultad de Medicina Revista

    1999-01-01

    Full Text Available Premio Nacional de Ciencias de la Salud "Alberto Lleras Camargo / Novedades Docentes / Año sabático / Promociones / Ingresos a Carrera Docente / En período de prueba / Cambio de dedicación / Conformación del Grupo De Asesoría y Desarrollo Pedagógico / Grupo De Gestión y Desarrollo Académico / Estado actual de los postgrados en la Facultad de Medicina / Desarrollo del componente / Comité de Ética de la Facultad de Medicina / Lanzamiento del libro «Cirugía Básica» del Profesor Rubén Caicedo / Cursos electivos.

  12. Vida académica de la facultad

    OpenAIRE

    Facultad de Medicina Revista

    1999-01-01

    Premio Nacional de Ciencias de la Salud "Alberto Lleras Camargo / Novedades Docentes / Año sabático / Promociones / Ingresos a Carrera Docente / En período de prueba / Cambio de dedicación / Conformación del Grupo De Asesoría y Desarrollo Pedagógico / Grupo De Gestión y Desarrollo Académico / Estado actual de los postgrados en la Facultad de Medicina / Desarrollo del componente / Comité de Ética de la Facultad de Medicina / Lanzamiento del libro «Cirugía Básica» del Profesor Rubén Caicedo / C...

  13. Vida académica de la facultad

    OpenAIRE

    Revista, Facultad de Medicina

    2010-01-01

    Premio Nacional de Ciencias de la Salud "Alberto Lleras Camargo / Novedades Docentes / Año sabático / Promociones / Ingresos a Carrera Docente / En período de prueba / Cambio de dedicación / Conformación del Grupo De Asesoría y Desarrollo Pedagógico / Grupo De Gestión y Desarrollo Académico / Estado actual de los postgrados en la Facultad de Medicina / Desarrollo del componente / Comité de Ética de la Facultad de Medicina / Lanzamiento del libro «Cirugía Básica» del Profesor Rubén Caicedo / C...

  14. Asociación entre las habilidades mentales primarias y el rendimiento académico en estudiantes de medicina de pregrado

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Gómez-López

    2013-01-01

    Full Text Available Con el propósito de analizar la asociación que existe entre las habilidades mentales primarias cuando se ingresa a la carrera de medicina y el rendimiento académico cuando se termina el octavo semestre, se realizó un estudio observacional y retrospectivo en 121 egresados de la Licenciatura de Medicina de una escuela particular del norte de México. Las habilidades mentales primarias se consideraron como variables predictoras, en tanto el rendimiento académico se asumió como variables de resultado. El razonamiento y la comprensión verbal presentaron asociación estadísticamente significativa con el rendimiento académico, arrojando un valor de p = 0,013 y 0,029, respectivamente, por lo que podemos concluir que el rendimiento académico en estudiantes de medicina requiere principalmente del razonamiento y de la comprensión verbal.

  15. Associations between dopamine D4 receptor gene variation with both infidelity and sexual promiscuity.

    Science.gov (United States)

    Garcia, Justin R; MacKillop, James; Aller, Edward L; Merriwether, Ann M; Wilson, David Sloan; Lum, J Koji

    2010-11-30

    Human sexual behavior is highly variable both within and between populations. While sex-related characteristics and sexual behavior are central to evolutionary theory (sexual selection), little is known about the genetic bases of individual variation in sexual behavior. The variable number tandem repeats (VNTR) polymorphism in exon III of the human dopamine D4 receptor gene (DRD4) has been correlated with an array of behavioral phenotypes and may be predicatively responsible for variation in motivating some sexual behaviors, particularly promiscuity and infidelity. We administered an anonymous survey on personal history of sexual behavior and intimate relationships to 181 young adults. We also collected buccal wash samples and genotyped the DRD4 VNTR. Here we show that individuals with at least one 7-repeat allele (7R+) report a greater categorical rate of promiscuous sexual behavior (i.e., having ever had a "one-night stand") and report a more than 50% increase in instances of sexual infidelity. DRD4 VNTR genotype varies considerably within and among populations and has been subject to relatively recent, local selective pressures. Individual differences in sexual behavior are likely partially mediated by individual genetic variation in genes coding for motivation and reward in the brain. Conceptualizing these findings in terms of r/K selection theory suggests a mechanism for selective pressure for and against the 7R+ genotype that may explain the considerable global allelic variation for this polymorphism.

  16. Associations between Dopamine D4 Receptor Gene Variation with Both Infidelity and Sexual Promiscuity

    Science.gov (United States)

    Garcia, Justin R.; MacKillop, James; Aller, Edward L.; Merriwether, Ann M.; Wilson, David Sloan; Lum, J. Koji

    2010-01-01

    Background Human sexual behavior is highly variable both within and between populations. While sex-related characteristics and sexual behavior are central to evolutionary theory (sexual selection), little is known about the genetic bases of individual variation in sexual behavior. The variable number tandem repeats (VNTR) polymorphism in exon III of the human dopamine D4 receptor gene (DRD4) has been correlated with an array of behavioral phenotypes and may be predicatively responsible for variation in motivating some sexual behaviors, particularly promiscuity and infidelity. Methodology/Principal Findings We administered an anonymous survey on personal history of sexual behavior and intimate relationships to 181 young adults. We also collected buccal wash samples and genotyped the DRD4 VNTR. Here we show that individuals with at least one 7-repeat allele (7R+) report a greater categorical rate of promiscuous sexual behavior (i.e., having ever had a “one-night stand”) and report a more than 50% increase in instances of sexual infidelity. Conclusions/Significance DRD4 VNTR genotype varies considerably within and among populations and has been subject to relatively recent, local selective pressures. Individual differences in sexual behavior are likely partially mediated by individual genetic variation in genes coding for motivation and reward in the brain. Conceptualizing these findings in terms of r/K selection theory suggests a mechanism for selective pressure for and against the 7R+ genotype that may explain the considerable global allelic variation for this polymorphism. PMID:21152404

  17. Associations between dopamine D4 receptor gene variation with both infidelity and sexual promiscuity.

    Directory of Open Access Journals (Sweden)

    Justin R Garcia

    2010-11-01

    Full Text Available Human sexual behavior is highly variable both within and between populations. While sex-related characteristics and sexual behavior are central to evolutionary theory (sexual selection, little is known about the genetic bases of individual variation in sexual behavior. The variable number tandem repeats (VNTR polymorphism in exon III of the human dopamine D4 receptor gene (DRD4 has been correlated with an array of behavioral phenotypes and may be predicatively responsible for variation in motivating some sexual behaviors, particularly promiscuity and infidelity.We administered an anonymous survey on personal history of sexual behavior and intimate relationships to 181 young adults. We also collected buccal wash samples and genotyped the DRD4 VNTR. Here we show that individuals with at least one 7-repeat allele (7R+ report a greater categorical rate of promiscuous sexual behavior (i.e., having ever had a "one-night stand" and report a more than 50% increase in instances of sexual infidelity.DRD4 VNTR genotype varies considerably within and among populations and has been subject to relatively recent, local selective pressures. Individual differences in sexual behavior are likely partially mediated by individual genetic variation in genes coding for motivation and reward in the brain. Conceptualizing these findings in terms of r/K selection theory suggests a mechanism for selective pressure for and against the 7R+ genotype that may explain the considerable global allelic variation for this polymorphism.

  18. Felicidade, bem-estar subjetivo e comportamento acadêmico de estudantes universitários Felicidad, bienestar subjetivo y comportamiento académico de estudiantes universitarios Happiness, subjective well-being and the academic behavior of university students

    Directory of Open Access Journals (Sweden)

    José Augusto Dela Coleta

    2006-12-01

    Full Text Available Este estudo teve como objetivo determinar índices de felicidade e bem-estar e sua relação com o comportamento acadêmico, em uma amostra de 252 estudantes universitários dos últimos períodos de diversos cursos e diferentes instituições de educação superior. Os sujeitos foram solicitados a responder a um questionário composto de perguntas sobre dados biográficos e escalas sobre o sentimento de felicidade, satisfação e bem-estar subjetivo, avaliações de vários aspectos de suas vidas, de sua universidade, de sua formação e comportamento acadêmico. Os resultados mostraram que estes estudantes avaliam sua satisfação, bem-estar e felicidade de modo bastante positivo. De modo geral eles estão satisfeitos com a faculdade e com o próprio rendimento acadêmico, embora se preocupem um pouco com a garantia de sucesso profissional que a formação recebida lhes possa oferecer. A principal hipótese foi confirmada ao se encontrar coeficiente de correlação múltipla significativo entre as medidas de bem-estar subjetivo e o comportamento acadêmico-universitário.Este estudio tuvo como objetivo determinar índices de felicidad y bienestar y su relación con el comportamiento académico, en una muestra de 252 estudiantes universitarios en los últimos períodos de diversos cursos y diferentes instituciones de educación superior. Los sujetos fueron solicitados a responder a un cuestionario compuesto de preguntas sobre datos biográficos y escalas sobre el sentimiento de felicidad, satisfacción y bienestar subjetivo, evaluaciones de varios aspectos de sus vidas, de su universidad, de su formación y comportamiento académico. Los resultados mostraron que estos estudiantes evalúan su satisfacción, bienestar y felicidad de modo bastante positivo. De modo general ellos están satisfechos con la facultad y con el propio rendimiento académico, aunque se preocupen un poco con la garantía de éxito profesional que la formación recibida

  19. Búsqueda de patrones de rendimiento académico mediante técnicas de análisis multivariante. Aplicación a 1º E4

    Directory of Open Access Journals (Sweden)

    Rúa Vieytes, Antonio

    2001-01-01

    Full Text Available A partir de técnicas estadísticas de análisis multivariante se ha podido constatar la existencia de una estructura subyacente dentro del conjunto de todas las asignaturas cursadas por los alumnos de 1º de E4. Esta estructura queda plasmada a través de cuatro factores básicos e intrínsecos a la licenciatura cursada (Factor Cuantitativo, Factor Lingüístico Humanístico, Factor Empresarial y Factor 2º Idioma. Asimismo, a partir de estos factores y mediante un análisis de conglomerados se han encontrado ocho tipologías o patrones de comportamiento de los alumnos en relación con su rendimiento académico, a saber: buen rendimiento académico, situaciones atípicas, rendimientos académicos pésimos, rendimientos académicos malos, rendimientos académicos que destacan en alguna faceta y rendimiento académico normal.

  20. Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

    DEFF Research Database (Denmark)

    Purrington, Kristen S; Slettedahl, Seth; Bolla, Manjeet K

    2014-01-01

    polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16-1.33, P = 4.2 × 10......Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide......(-10)) and EIF3H (rs799890: OR = 1.07, 95% CI 1.04-1.11, P = 8.7 × 10(-6)) were significantly associated with risk of low-grade breast cancer. The TACC2 signal was retained (rs17550038: OR = 1.15, 95% CI 1.07-1.23, P = 7.9 × 10(-5)) after adjustment for breast cancer risk SNPs in the nearby FGFR2 gene...

  1. Immune gene expression in Bombus terrestris: signatures of infection despite strong variation among populations, colonies, and sister workers.

    Directory of Open Access Journals (Sweden)

    Franziska S Brunner

    Full Text Available Ecological immunology relies on variation in resistance to parasites. Colonies of the bumblebee Bombus terrestris vary in their susceptibility to the trypanosome gut parasite Crithidia bombi, which reduces colony fitness. To understand the possible origin of this variation in resistance we assayed the expression of 28 immunologically important genes in foraging workers. We deliberately included natural variation of the host "environment" by using bees from colonies collected in two locations and sampling active foraging workers that were not age controlled. Immune gene expression patterns in response to C. bombi showed remarkable variability even among genetically similar sisters. Nevertheless, expression varied with parasite exposure, among colonies and, perhaps surprisingly, strongly among populations (collection sites. While only the antimicrobial peptide abaecin is universally up regulated upon exposure, linear discriminant analysis suggests that the overall exposure effect is driven by a combination of several immune pathways and further immune functions such as ROS regulation. Also, the differences among colonies in their immune gene expression profiles provide clues to the mechanistic basis of well-known inter-colony variation in susceptibility to this parasite. Our results show that transcriptional responses to parasite exposure can be detected in ecologically heterogeneous groups despite strong background noise.

  2. Cuidados paliativos em oncologia pediátrica na percepção dos acadêmicos de enfermagem

    Directory of Open Access Journals (Sweden)

    Tuani Magalhães Guimarães

    2016-06-01

    Full Text Available RESUMO Objetivo: Conhecer a percepção dos acadêmicos de enfermagem sobre cuidados paliativos em oncologia pediátrica. Métodos: Pesquisa exploratória, abordagem qualitativa, desenvolvida em 2014, na Escola de Enfermagem de uma Universidade Federal no Rio de Janeiro. Realizada entrevista semiestruturada com vinte acadêmicos do último período da graduação. Na análise dos dados emergiram duas unidades temáticas: percepção dos acadêmicos quanto aos cuidados paliativos em oncologia pediátrica e quanto à atuação da equipe profissional. Resultados: Para os acadêmicos, os cuidados paliativos em oncologia pediátrica estão relacionados ao controle de sinais e sintomas, conforto, apoio, promoção da qualidade de vida e bem-estar. Por outro lado, alguns entendem que o cuidado paliativo tem como objetivo prolongar o tempo de vida. Percebem a necessidade da atuação da equipe multiprofissional junto à criança e sua família. Conclusão: A complexidade e os múltiplos aspectos envolvidos no cuidado paliativo exige que o mesmo seja abordado durante a graduação dos Enfermeiros.

  3. CAG repeat length variation in the polymerase gamma (POLG) gene: effect on semen quality

    NARCIS (Netherlands)

    Westerveld, G. H.; Kaaij-Visser, L.; Tanck, M.; van der Veen, F.; Repping, S.

    2008-01-01

    Several case-control studies have investigated the effect of CAG repeat length variation in the POLG gene on male fertility and semen quality. Some described an association between the homozygous not10 CAG-repeat genotype and male subfertility and/or reduced semen quality, whereas others did not.

  4. Mujer y ciencia: Políticas de igualdad y excelencia académica

    Directory of Open Access Journals (Sweden)

    Quintanilla Fisac, Miguel A.

    2008-10-01

    Full Text Available We must avoid the waste of women along academic career. Several countries, such as Spain, are trying out affirmative actions in order to avoid it. These policies are compatible with and adequate scientific policy based in academic excellence and merit standards.La pérdida de mujeres a lo largo de la carrera académica es una constante que debemos evitar a toda costa. En diferentes países, incluido el nuestro, se están poniendo en marcha políticas de discriminación positiva para evitarlo. Estas políticas son compatibles con una adecuada política científica que se base en criterios de mérito y excelencia académica.

  5. Natural Variation in Synthesis and Catabolism Genes Influences Dhurrin Content in Sorghum

    Directory of Open Access Journals (Sweden)

    Chad M. Hayes

    2015-07-01

    Full Text Available Cyanogenic glucosides are natural compounds found in more than 1000 species of angiosperms that produce HCN and are deemed undesirable for agricultural use. However, these compounds are important components of the primary defensive mechanisms of many plant species. One of the best-studied cyanogenic glucosides is dhurrin [(--hydroxymandelonitrile-β--glucopyranoside], which is produced primarily in sorghum [ (L. Moench]. The biochemical basis for dhurrin metabolism is well established; however, little information is available on its genetic control. Here, we dissect the genetic control of leaf dhurrin content through a genome-wide association study (GWAS using a panel of 700 diverse converted sorghum lines (conversion panel previously subjected to pre-breeding and selected for short stature (∼1 m in height and photoperiod insensitivity. The conversion panel was grown for 2 yr in three environments. Wide variation for leaf dhurrin content was found in the sorghum conversion panel, with the Caudatum group exhibiting the highest dhurrin content and the Guinea group showing the lowest dhurrin content. A GWAS using a mixed linear model revealed significant associations (a false discovery rate [FDR] < 0.05 close to both UGT 185B1 in the canonical biosynthetic gene cluster on chromosome 1 and close to the catabolic dhurrinase loci on chromosome 8. Dhurrin content was associated consistently with biosynthetic genes in the two N-fertilized environments, while dhurrin content was associated with catabolic loci in the environment without supplemental N. These results suggest that genes for both biosynthesis and catabolism are important in determining natural variation for leaf dhurrin in sorghum in different environments.

  6. Autorregulación, metas y rendimiento académico en bachilleres con disposiciones resilientes y no resilientes

    Directory of Open Access Journals (Sweden)

    José Concepción Gaxiola Romero

    2013-01-01

    Full Text Available Existen factores de riesgo que afectan el rendimiento académico de los adolescentes de bachillerato; éstos pueden ser contextuales e individuales. La resiliencia implica la superación de los riesgos que se enfrentan. A partir de lo anterior, el objetivo del presente estudio fue probar un modelo hipotético general de ecuaciones estructurales en dos grupos de estudiantes de bachillerato, uno de resiliencia y otro de no resiliencia, con el fin de evaluar el impacto que tienen las variables contextuales, las metas, y la autorregulación sobre el rendimiento académico. Previo consentimiento informado, se aplicaron instrumentos validados y los datos se probaron en dos modelos de ecuaciones estructurales. Los resultados muestran diferencias en el impacto de las variables contextuales de riesgo en ambos grupos sobre el rendimiento académico.

  7. Diversity and population-genetic properties of copy number variations and multicopy genes in cattle

    Science.gov (United States)

    Bickhart, Derek M.; Xu, Lingyang; Hutchison, Jana L.; Cole, John B.; Null, Daniel J.; Schroeder, Steven G.; Song, Jiuzhou; Garcia, Jose Fernando; Sonstegard, Tad S.; Van Tassell, Curtis P.; Schnabel, Robert D.; Taylor, Jeremy F.; Lewin, Harris A.; Liu, George E.

    2016-01-01

    The diversity and population genetics of copy number variation (CNV) in domesticated animals are not well understood. In this study, we analysed 75 genomes of major taurine and indicine cattle breeds (including Angus, Brahman, Gir, Holstein, Jersey, Limousin, Nelore, and Romagnola), sequenced to 11-fold coverage to identify 1,853 non-redundant CNV regions. Supported by high validation rates in array comparative genomic hybridization (CGH) and qPCR experiments, these CNV regions accounted for 3.1% (87.5 Mb) of the cattle reference genome, representing a significant increase over previous estimates of the area of the genome that is copy number variable (∼2%). Further population genetics and evolutionary genomics analyses based on these CNVs revealed the population structures of the cattle taurine and indicine breeds and uncovered potential diversely selected CNVs near important functional genes, including AOX1, ASZ1, GAT, GLYAT, and KRTAP9-1. Additionally, 121 CNV gene regions were found to be either breed specific or differentially variable across breeds, such as RICTOR in dairy breeds and PNPLA3 in beef breeds. In contrast, clusters of the PRP and PAG genes were found to be duplicated in all sequenced animals, suggesting that subfunctionalization, neofunctionalization, or overdominance play roles in diversifying those fertility-related genes. These CNV results provide a new glimpse into the diverse selection histories of cattle breeds and a basis for correlating structural variation with complex traits in the future. PMID:27085184

  8. Integração ao ensino superior e satisfação acadêmica em universitários

    Directory of Open Access Journals (Sweden)

    Acácia Aparecida Angeli dos Santos

    Full Text Available O presente estudo teve como objetivos avaliar a integração e a satisfação acadêmica em universitários e analisar sua relação, conforme o curso e a etapa de formação. Participaram 203 estudantes dos cursos de Psicologia (n=76 e Odontologia (n=127 de uma universidade particular, sendo a maioria mulheres (n=158. Foram aplicados um Questionário de Vivência Acadêmica (QVA-r e uma Escala de Satisfação Acadêmica (ESEA. Os resultados mostraram que os estudantes apresentaram níveis de integração e de satisfação superior à média. Foram detectadas diferenças entre os cursos relativas às variáveis focalizadas e correlações entre as dimensões. É possível afirmar que a integração e a satisfação, apesar de compartilhar aspectos comuns, avaliam construtos diferentes, ambos importantes para a compreensão do fenômeno complexo e multideterminado da vida acadêmica.

  9. Rendimiento académico e interacción sociocognitiva de estudiantes en un entorno virtual

    Directory of Open Access Journals (Sweden)

    Ana Borgobello

    2016-06-01

    Full Text Available Resumen El objetivo de este estudio fue el análisis del rendimiento académico vinculado con las características de interacción sociocognitiva en un entorno virtual, en un curso con diseño híbrido o blended learning de nivel universitario. El caso sostuvo un diseño multi-método basado en una estrategia ecológica observacional y un cuestionamiento a mediciones tradicionales de rendimiento académico. Se analizaron los clics –entradas en distintas zonas del entorno- realizados en la plataforma para navegar en el entorno, los mensajes escritos en foros, las respuestas a un cuestionario sobre hábitos y opiniones y las calificaciones obtenidas en exámenes regulares. Los tres ejes de análisis fueron: 1 relación entre uso de la plataforma con calificaciones académicas, opiniones y hábitos; 2 construcción de perfiles de sujetos a partir de análisis de clases en relación a las variables anteriores; 3 características de los mensajes escritos en foros de cinco sujetos con alto y bajo rendimiento académico general. Los resultados muestran que 1 hubo diferencias significativas en las calificaciones y el agrado por utilizar la plataforma; 2 se distinguieron tres clases: uso bajo, medio y alto de plataforma con preferencias distintas en recursos, agrado al utilizarla, entre otros; 3 hubo diferencias notables en el contenido de los mensajes, especialmente en lo no estrictamente cognitivo.

  10. Adaptación de la Escala de Satisfacción Académica a la Población Universitaria de Córdoba

    Directory of Open Access Journals (Sweden)

    Leonardo Adrián Medrano

    2013-08-01

    Full Text Available La satisfacción académica constituye un constructo clave que explica en parte el ajuste académico, la integración social., la persistencia, el éxito académico y la satisfacción general con la vida, por parte de los estudiantes. Aunque en el ámbito internacional se han construido diferentes instrumentos para medir la satisfacción académica, en nuestro medio no se dispone de escalas que permitan evaluar este constructo. El objetivo principal del presente trabajo fue adaptar una escala de Satisfacción Académica a la población local de estudiantes universitarios. Para ello participaron 258 estudiantes de diferentes carreras y se realizaron estudios de estructura interna y consistencia interna utilizando análisis factorial exploratorio y coeficiente Alfa de Cronbach (α, respectivamente. Los resultados obtenidos sugieren una estructura interna unidimensional que explica un 49% de la variabilidad de respuesta, así como una elevada homogeneidad (α = .84 de la escala. Aunque los resultados iniciales son alentadores deberían realizarse estudios psicométricos complementarios.

  11. Autorregulación, Resiliencia y Metas Educativas: Variables Protectoras del Rendimiento Académico de Bachilleres

    OpenAIRE

    JOSÉ CONCEPCIÓN GAXIOLA ROMERO; SANDYBELL GONZÁLEZ LUGO; EUNICE GAXIOLA VILLA

    2013-01-01

    En México, el rendimiento académico de bachillerato es deficiente, por lo que es necesario estudiar sus variables predictoras para mejorarlo. El objetivo del estudio fue medir las trayectorias entre las variables autorregulación, resiliencia y metas educativas en el rendimiento académico de estudiantes de bachillerato, ante la percepción del comportamiento de riesgo de los amigos y la percepción del ambiente escolar de riesgo. Se entrevistaron 120 estudiantes de bachillerato con el más bajo a...

  12. Estrés académico, "engagement" y resiliencia en estudiantes de enfermería.

    OpenAIRE

    Berzosa Honrado, Raquel

    2017-01-01

    El estrés académico tiene una alta prevalencia actualmente. Esto es relevante, puesto que altos niveles de estrés repercutirán negativamente en la salud y en el rendimiento académico. Además, diversos análisis han señalado que en los estudiantes de Ciencias de la Salud estos niveles son más elevados. Por lo tanto, se hace necesario analizar el estrés en alumnos de Enfermería, así como variables que influyan sobre los mismos. Conocer dichos resultados orientaría hacia actuaciones preventivas y...

  13. Race/Ethnic Based Genetic Variations in Human Genes: Defining the Genetic Evidence for Disparity of Prostate Cancer Risk and Mortality Between Different Populations

    National Research Council Canada - National Science Library

    Franklin, John

    1999-01-01

    .... The study will evaluate variations in androgen receptor gene, the vitamin D receptor gene, and the APOJ/clusterin gene by amplifying specific DNA segments from certain genes utilizing a commonly used...

  14. Effects of abhydrolase domain containing 5 gene (ABHD5) expression and variations on chicken fat metabolism.

    Science.gov (United States)

    Ouyang, Hongjia; Liu, Qing; Xu, Jiguo; Zeng, Fang; Pang, Xiaolin; Jebessa, Endashaw; Liang, Shaodong; Nie, Qinghua; Zhang, Xiquan

    2016-01-01

    Abhydrolase domain containing 5 gene (ABHD5), also known as comparative gene identification 58 (CGI-58), is a member of the α/β-hydrolase family as a protein cofactor of ATGL stimulating its triacylglycerol hydrolase activity. In this study, we aim to characterize the expression and variations of ABHD5 and to study their functions in chicken fat metabolism. We compared the ABHD5 expression level in various tissues and under different nutrition conditions, identified the variations of ABHD5, and associated them with production traits in an F2 resource population of chickens. Overexpression analysis with two different genotypes and siRNA interfering analysis of ABHD5 were performed in chicken preadipocytes. Chicken ABDH5 was expressed widely and most predominantly in adipose tissue. Five SNPs of the ABHD5 gene were identified and genotyped in the F2 resource population. The c.490C > T SNP was associated with subcutaneous fat thickness (P  C SNP was also associated with chicken body weight (P chicken preadipocytes, overexpression of wild type ABDH5 did not affect the mRNA level of ATGL (adipose triglyceride lipase) but markedly decreased (P chickens with a high fat diet. These results suggest that expression and variations of ABHD5 may affect fat metabolism through regulating the activity of ATGL in chickens. © 2015 Poultry Science Association Inc.

  15. Gene expression variation resolves species and individual strains among coral-associated dinoflagellates within the genus Symbiodinium

    KAUST Repository

    Parkinson, John Everett; Baumgarten, Sebastian; Michell, Craig; Baums, Iliana B.; LaJeunesse, Todd C.; Voolstra, Christian R.

    2016-01-01

    Reef-building corals depend on symbiotic mutualisms with photosynthetic dinoflagellates in the genus Symbiodinium. This large microalgal group comprises many highly divergent lineages (“Clades A-I”) and hundreds of undescribed species. Given their ecological importance, efforts have turned to genomic approaches to characterize the functional ecology of Symbiodinium. To date, investigators have only compared gene expression between representatives from separate clades—the equivalent of contrasting genera or families in other dinoflagellate groups—making it impossible to distinguish between clade-level and species-level functional differences. Here, we examined the transcriptomes of four species within one Symbiodinium clade (Clade B) at ~20,000 orthologous genes, as well as multiple isoclonal cell lines within species (i.e. cultured strains). These species span two major adaptive radiations within Clade B, each encompassing both host-specialized and ecologically cryptic taxa. Species-specific expression differences were consistently enriched for photosynthesis-related genes, likely reflecting selection pressures driving niche diversification. Transcriptional variation among strains involved fatty acid metabolism and biosynthesis pathways. Such differences among individuals are potentially a major source of physiological variation, contributing to the functional diversity of coral holobionts composed of unique host-symbiont genotype pairings. Our findings expand the genomic resources available for this important symbiont group and emphasize the power of comparative transcriptomics as a method for studying speciation processes and inter-individual variation in non-model organisms.

  16. Gene expression variation resolves species and individual strains among coral-associated dinoflagellates within the genus Symbiodinium

    KAUST Repository

    Parkinson, John Everett

    2016-02-11

    Reef-building corals depend on symbiotic mutualisms with photosynthetic dinoflagellates in the genus Symbiodinium. This large microalgal group comprises many highly divergent lineages (“Clades A-I”) and hundreds of undescribed species. Given their ecological importance, efforts have turned to genomic approaches to characterize the functional ecology of Symbiodinium. To date, investigators have only compared gene expression between representatives from separate clades—the equivalent of contrasting genera or families in other dinoflagellate groups—making it impossible to distinguish between clade-level and species-level functional differences. Here, we examined the transcriptomes of four species within one Symbiodinium clade (Clade B) at ~20,000 orthologous genes, as well as multiple isoclonal cell lines within species (i.e. cultured strains). These species span two major adaptive radiations within Clade B, each encompassing both host-specialized and ecologically cryptic taxa. Species-specific expression differences were consistently enriched for photosynthesis-related genes, likely reflecting selection pressures driving niche diversification. Transcriptional variation among strains involved fatty acid metabolism and biosynthesis pathways. Such differences among individuals are potentially a major source of physiological variation, contributing to the functional diversity of coral holobionts composed of unique host-symbiont genotype pairings. Our findings expand the genomic resources available for this important symbiont group and emphasize the power of comparative transcriptomics as a method for studying speciation processes and inter-individual variation in non-model organisms.

  17. Schooling and variation in the COMT gene: the devil is in the details.

    Science.gov (United States)

    Campbell, Daniel; Bick, Johanna; Yrigollen, Carolyn M; Lee, Maria; Joseph, Antony; Chang, Joseph T; Grigorenko, Elena L

    2013-10-01

    Schooling is considered one of the major contributors to the development of intelligence within societies and individuals. Genetic variation might modulate the impact of schooling and explain, at least partially, the presence of individual differences in classrooms. We studied a sample of 1,502 children (mean age = 11.7 years) from Zambia. Approximately 57% of these children were enrolled in school, and the rest were not. To quantify genetic variation, we investigated a number of common polymorphisms in the catechol-O-methyltransferase (COMT) gene that controls the production of the protein thought to account for >60% of the dopamine degradation in the prefrontal cortex. Haplotype analyses generated results ranging from the presence to absence of significant interactions between a number of COMT haplotypes and indicators of schooling (i.e., in- vs. out-of-school and grade completed) in the prediction of nonverbal intelligence, depending on the parameter specification. However, an investigation of the distribution of corresponding p-values suggested that these positive results were false. Convincing evidence that the variation in the COMT gene is associated with individual differences in nonverbal intelligence either directly or through interactions with schooling was not found. p-values produced by the method of testing for haplotype effects employed here may be sensitive to parameter settings, invalid under default settings, and should be checked for validity through simulation. © 2013 The Authors. Journal of Child Psychology and Psychiatry © 2013 Association for Child and Adolescent Mental Health.

  18. Evaluación del rendimiento académico de estudiantes universitarios en la modalidad presencial y virtual

    Directory of Open Access Journals (Sweden)

    Fernando Pablo Ñaupari Rafael

    2014-06-01

    Full Text Available Objetivo: Evaluar el impacto de la modalidad presencial y virtual en el rendimiento académico de los estudiantes de la Universidad Continental. Método: Investigación de naturaleza descriptiva y transversal, utilizó un diseño descriptivo comparativo, comparando índices vinculados al rendimiento académico, en una muestra de estudiantes de la modalidad presencial y otra de la modalidad virtual de la Universidad Continental, de las carreras de Administración, Contabilidad, Derecho, Ingeniería de Sistemas e Ingeniería Industrial. El recojo de datos utilizó la técnica del análisis documental, a través de las actas promocionales del ciclo académico 2013-I. Resultados: En la modalidad presencial, 10,7% de los estudiantes alcanza un promedio superior a 14,5 mientras que 33,1% obtiene promedios menores de 10,5. Además, casi la mitad de los estudiantes presentan un índice de aprobación inferior a 80%, es decir, aprueban menos de 8 asignaturas de cada 10 que cursan. En la modalidad virtual, 9,6% alcanza un promedio superior a 14,5, mientras que 55,7% obtiene promedios menores de 10,5. Además, casi el 70% de los estudiantes presenta un índice de aprobación inferior a 80%, es decir, aprueban menos de 8 asignaturas de cada 10 que cursan. Conclusiones: El rendimiento académico de los estudiantes de la modalidad presencial y la modalidad virtual es bajo, caracterizado por un promedio desaprobatorio menor de 10,5 y un índice de aprobación bajo. De ellas, la modalidad virtual presentó un rendimiento académico de 69,5%, y la modalidad presencial un 45,8%.

  19. El burnout académico: delimitación del síndrome y factores asociados con su aparición

    OpenAIRE

    Carmen Cecilia Caballero Domínguez; Christian Hederich; Jorge Enrique Palacio Sañudo

    2010-01-01

    El artículo presenta una revisión de los principales conceptos del síndrome de burnout académico, su evolución y su delimitación conceptual con otros trastornos como depresión y ansiedad, así como también una revisión de los modelos teóricos del burnout en el ámbito laboral para su aplicación en el ámbito académico. Además, se contextualizan las variables asociadas a su desarrollo y sus consecuencias en el rendimiento académico y en la salud mental de estudiantes universitarios.

  20. El burnout académico: delimitación del síndrome y factores asociados con su aparición

    OpenAIRE

    Caballero Domínguez, Carmen Cecilia; Hederich, Christian; Palacio Sañudo, Jorge Enrique

    2010-01-01

    El artículo presenta una revisión de los principales conceptos del síndrome de burnout académico, su evolución y su delimitación conceptual con otros trastornos como depresión y ansiedad, así como también una revisión de los modelos teóricos del burnout en el ámbito laboral para su aplicación en el ámbito académico. Además, se contextualizan las variables asociadas a su desarrollo y sus consecuencias en el rendimiento académico y en la salud mental de estudiantes universitarios. The articl...

  1. Rusia en el Proceso de Bolonia: Compatibilidad, competitividad y movilidad académica

    Directory of Open Access Journals (Sweden)

    Edgar Demetrio Tovar García

    2014-05-01

    Full Text Available El presente artículo describe la inclusión de Rusia en el proceso de Bolonia. Además de la revisión bibliográfica, la descripción de los eventos y sus resultados con respecto a dos objetivos primordiales de la Declaración (compatibilidad-competitividad y movilidad académica son evidenciados y ejemplificados con información obtenida por medio de entrevistas a informantes clave, 35 estudiantes (entre ellos líderes estudiantiles y 12 profesores (entre ellos jefes de departamento de dos de las universidades moscovitas más grandes. Los resultados indican que el proceso de Bolonia en Rusia es incipiente, caracterizado por incredibilidad sobre la calidad de la educación superior rusa, corrupción, y baja movilidad académica.

  2. Colony-level behavioural variation correlates with differences in expression of the foraging gene in red imported fire ants.

    Science.gov (United States)

    Bockoven, Alison A; Coates, Craig J; Eubanks, Micky D

    2017-11-01

    Among social insects, colony-level variation is likely to be widespread and has significant ecological consequences. Very few studies, however, have documented how genetic factors relate to behaviour at the colony level. Differences in expression of the foraging gene have been associated with differences in foraging and activity of a wide variety of organisms. We quantified expression of the red imported fire ant foraging gene (sifor) in workers from 21 colonies collected across the natural range of Texas fire ant populations, but maintained under standardized, environmentally controlled conditions. Colonies varied significantly in their behaviour. The most active colonies had up to 10 times more active foragers than the least active colony and more than 16 times as many workers outside the nest. Expression differences among colonies correlated with this colony-level behavioural variation. Colonies with higher sifor expression in foragers had, on average, significantly higher foraging activity, exploratory activity and recruitment to nectar than colonies with lower expression. Expression of sifor was also strongly correlated with worker task (foraging vs. working in the interior of the nest). These results provide insight into the genetic and physiological processes underlying collective differences in social behaviour. Quantifying variation in expression of the foraging gene may provide an important tool for understanding and predicting the ecological consequences of colony-level behavioural variation. © 2017 John Wiley & Sons Ltd.

  3. Variations and classification of toxic epitopes related to celiac disease among α-gliadin genes from four Aegilops genomes.

    Science.gov (United States)

    Li, Jie; Wang, Shunli; Li, Shanshan; Ge, Pei; Li, Xiaohui; Ma, Wujun; Zeller, F J; Hsam, Sai L K; Yan, Yueming

    2012-07-01

    The α-gliadins are associated with human celiac disease. A total of 23 noninterrupted full open reading frame α-gliadin genes and 19 pseudogenes were cloned and sequenced from C, M, N, and U genomes of four diploid Aegilops species. Sequence comparison of α-gliadin genes from Aegilops and Triticum species demonstrated an existence of extensive allelic variations in Gli-2 loci of the four Aegilops genomes. Specific structural features were found including the compositions and variations of two polyglutamine domains (QI and QII) and four T cell stimulatory toxic epitopes. The mean numbers of glutamine residues in the QI domain in C and N genomes and the QII domain in C, N, and U genomes were much higher than those in Triticum genomes, and the QI domain in C and N genomes and the QII domain in C, M, N, and U genomes displayed greater length variations. Interestingly, the types and numbers of four T cell stimulatory toxic epitopes in α-gliadins from the four Aegilops genomes were significantly less than those from Triticum A, B, D, and their progenitor genomes. Relationships between the structural variations of the two polyglutamine domains and the distributions of four T cell stimulatory toxic epitopes were found, resulting in the α-gliadin genes from the Aegilops and Triticum genomes to be classified into three groups.

  4. Revisión entre iguales y escritura académica en la universidad: la perspectiva del estudiante

    Directory of Open Access Journals (Sweden)

    Alfonso Vargas Franco

    2014-01-01

    Full Text Available Este artículo presenta los primeros resultados de una investigación que tuvo como objeto documentar los puntos de vista (representaciones, grado de conciencia, actitudes, opiniones que tiene un grupo de estudiantes, desde una perspectiva émica (una perspectiva del informante, del estudiante, que también es autor del texto, sobre la escritura académica, sus roles de autor y lector y los procesos de revisión entre iguales, en una secuencia de aprendizaje de resúmenes, reseñas y artículos académicos, en un aula universitaria. El corpus está constituido por una entrevista concebida como grupo de discusión, grabada y transcrita siguiendo el modelo del análisis del discurso, pero el estudio más amplio (Vargas Franco, 2013 describe y analiza entrevistas en profundidad y los textos académicos objeto de la revisión entre pares. El estudio de corte cualitativo-etnográfico arroja como resultados que la revisión entre iguales es más compleja de lo que parece, pero que puede resultar beneficiosa para que los estudiantes se apropien de las convenciones dominantes de la escritura académica, facilitando su proceso de integración en una nueva comunidad discursiva y cultural.

  5. Non-functional genes repaired at the RNA level.

    Science.gov (United States)

    Burger, Gertraud

    2016-01-01

    Genomes and genes continuously evolve. Gene sequences undergo substitutions, deletions or nucleotide insertions; mobile genetic elements invade genomes and interleave in genes; chromosomes break, even within genes, and pieces reseal in reshuffled order. To maintain functional gene products and assure an organism's survival, two principal strategies are used - either repair of the gene itself or of its product. I will introduce common types of gene aberrations and how gene function is restored secondarily, and then focus on systematically fragmented genes found in a poorly studied protist group, the diplonemids. Expression of their broken genes involves restitching of pieces at the RNA-level, and substantial RNA editing, to compensate for point mutations. I will conclude with thoughts on how such a grotesquely unorthodox system may have evolved, and why this group of organisms persists and thrives since tens of millions of years. Copyright © 2016 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  6. Relación del burnout y el engagement con depresión, ansiedad y rendimiento académico en estudiantes universitarios

    Directory of Open Access Journals (Sweden)

    Carmen Caballero Domínguez

    2015-01-01

    Full Text Available Objetivo: Analizar las relaciones entre burnout y engagement con ansiedad, depresión y rendimiento académico en estudiantes universitarios de programas de salud. Materiales y métodos: El diseño fue observacional, correlacional, multivariado; la muestra, aleatoria y estratificada, de 802 estudiantes de programas de salud de universidades de Barranquilla. Instrumentos: MBISS, UWES-S, STAI e Inventario de Depresión de Beck. Resultados: El análisis de las correspondencias múltiples entre las variables evidenció un factor conformado principalmente por las dimensiones de Vigor, Absorción, Dedicación e Ineficacia Académica, cuyo extremo negativo se relacionaba con bajo engagement y altos niveles de burnout, ineficacia académica, depresión y de ansiedad de rasgo y de estado; el extremo positivo, con alto engagement, buen rendimiento académico y baja ineficacia, depresión y ansiedad de rasgo y de estado. Conclusiones: En la muestra estudiada, el burnout y el engagement académicos se identificaron relacionados como polos extremos y opuestos de un mismo continuo multidimensional, en el que tanto el polo del burnout como el del engagement se configuran por valores esperados de las variables estudiadas pero opuestos al del polo contrario.

  7. Las “Lecciones Académicas” de Evangelista Torricelli

    Directory of Open Access Journals (Sweden)

    Rosa María Herrera

    2013-04-01

    Full Text Available En las Lecciones Académicas (“Lezioni accademiche”, Torricelli a la manera divulgativa dibujó un boceto de bastantes de sus ideas científicas, algunas novedosas, como la circulación general de la atmósfera. El estilo culto e irónico, pero informal, que utilizó le permitió exponer conceptos que de otra manera, dadas las circunstancias, hubiera sido casi imposible. En estas notas muestro algunos ejemplos.

  8. Differential hippocampal gene expression is associated with climate-related natural variation in memory and the hippocampus in food-caching chickadees.

    Science.gov (United States)

    Pravosudov, V V; Roth, T C; Forister, M L; Ladage, L D; Kramer, R; Schilkey, F; van der Linden, A M

    2013-01-01

    There is significant and often heritable variation in cognition and its underlying neural mechanisms, yet specific genetic contributions to such variation are not well characterized. Black-capped chickadees present a good model to investigate the genetic basis of cognition because they exhibit tremendous climate-related variation in memory, hippocampal morphology and neurogenesis rates throughout the North American continent, and these cognitive traits appear to have a heritable basis. We examined the hippocampal transcriptome profiles of laboratory-reared chickadees from the two most divergent populations to test whether differential gene expression in the hippocampus is associated with population differences in spatial memory, hippocampal morphology and adult hippocampal neurogenesis rates. Using high-resolution mRNA sequencing coupled to a de novo transcriptome assembly, we generated 23 295 consensus sequences, which predicted 16 206 protein sequences with 13 982 showing high similarity to known protein sequences or conserved hypothetical proteins in other species. Of these, we identified differential expression in nearly 380 genes, with 47 genes specifically linked to neurogenesis, apoptosis, synaptic function, and learning and memory processes. Many of the other differentially expressed genes, however, may be associated with other functions. Our study presents the first avian hippocampal transcriptome, and it is the first study identifying differential gene expression associated with natural variation in cognition and the hippocampus. Our results provide additional support to the hypothesis that population differences in memory, hippocampal morphology and neurogenesis in chickadees have likely resulted from natural selection that appears to act on memory and its underlying neural mechanisms. © 2012 Blackwell Publishing Ltd.

  9. APPS en el rendimiento académico y autoconcepto de estudiantes de ingeniería

    Directory of Open Access Journals (Sweden)

    Mawency Vergel Ortega

    2015-11-01

    Full Text Available La investigación fue realizada en la Universidad Francisco de Paula Santander de la ciudad de Cúcuta, Colombia, durante el I-2014, comparó dos métodos de enseñanza, a través de un grupo prueba donde estudiantes de ecuaciones diferenciales utilizan aplicativos móviles como la calculadora HD, wolfram alpha-powered apps, y un grupo control que recibió clases sin ayuda de aplicativos. Su objeto fue determinar la influencia del uso de apps en el rendimiento académico de estudiantes de ecuaciones diferenciales en ingeniería. A través de un enfoque cuantitativo, de tipo campo, una entrevista, un diario de observación y test de autoconcepto y ansiedad como instrumentos junto a resultados en evaluaciones, permitieron observar mejora en el rendimiento académico de los estudiantes, percepción positiva hacia las ecuaciones diferenciales, mejora en niveles de autoconcepto y disminución en puntuaciones de ansiedad. Palabras claves: Aprendizaje, tecnología de la información, Ecuaciones diferenciales, Educación superior, rendimiento académico          

  10. La Inteligencia Emocional como predictora del Rendimiento Académico: el contexto pluricultural de Ceuta

    Directory of Open Access Journals (Sweden)

    Federico Pulido Acosta

    2015-12-01

    Full Text Available Este trabajo tiene como objetivo fundamental conocer los predictores dela Inteligencia Emocional (IE y el Rendimiento Académico (RA del alumnado de la ciudad de Ceuta, para lo que se contó con 1186 participantes, de 9 centros educativos distintos, que reflejan la pluriculturalidad de la ciudad; de los cuales, el 57.8% son mujeres y el 42.2% varones, y el 58.9% de cultura/religión musulmana y el 41.1% cristianos. Como instrumentos de evaluación se emplearon una adaptación propia del MSCEIT (Test de Inteligencia Emocional de Mayer, Salovey y Caruso, 2009 y las calificaciones de los alumnos. Los resultados obtenidos reflejan niveles medios de Rendimiento Académico, y medio-altos en IE, actuando como predictores del primero las variables sociodemográficas de edad, género, cultura/religión y estatus socio-económico-cultural. Los predictores de la Inteligencia Emocional son la etapa y el estatus. Por otra parte, muestran que existe relación entre Inteligencia Emocional y Rendimiento Académico, actuando cada una como principal predictor de la otra.

  11. Letramentos acadêmicos e multimodalidade em contexto de EaD semipresencial

    Directory of Open Access Journals (Sweden)

    Fabiana Komesu

    2012-07-01

    Full Text Available De uma perspectiva teórica enunciativo-discursiva, este artigo tem como objetivo discutir o processo de constituição do texto em contexto digital, de maneira particularizada, por meio da problematização de modos e recursos semióticos atualizados na produção acadêmica do universitário que utiliza computador com acesso à internet no processo de Educação a Distância (EaD semipresencial. Interessa investigar como o modelo de letramentos acadêmicos pode ser articulado ao estudo da multimodalidade, considerando-se que em ambiente eletrônico o universitário tem, por hipótese, acesso “ilimitado” a todo e qualquer texto, não apenas ao chamado “verbal”, comumente atribuído ao elemento gráfico. O conjunto do material é formado de textos produzidos por alunos do Curso de Pedagogia semipresencial da Universidade Virtual do Estado de São Paulo (UNIVESP no ano de 2010.Palavras-chave: Escrita. Letramentos. Discurso. Educação a distância. Internet.

  12. La administración educativa y su influencia en el rendimiento académico de los alumnos del nivel secundario en Puno

    OpenAIRE

    Quispe Sairitupa, Míriam Edith

    2011-01-01

    La tesis titulada "La Administración Educativa y su Influencia en el Rendimiento Académico de los Alumnos del Nivel Secundario en Puno" se desarrolló en la ciudad de Puno en el año lectivo 2009, con ocho instituciones educativas del nivel secundario. El objetivo fue determinar la influencia que ejerce la administración educativa en el rendimiento académico de los estudiantes del nivel secundario de la ciudad de Puno, así como establecer el rendimiento académico de los estudiantes cuya direcci...

  13. Características psicológicas y desempeño académico en universitarios de profesiones de pronta ocupación

    OpenAIRE

    Angélica Riveros; Tomás Humberto Rubio; Julieta Candelario; Mariana Mangín

    2013-01-01

    El rendimiento académico hace evidentes contrastes entre las condiciones que enfrentan los alumnos y estados de bienestar y malestar psicológico. En México las principales razones de la deserción escolar son económicas, la necesidad de la inserción temprana en el campo laboral y bajo desempeño académico. El propósito del presente trabajo fue identificar los factores que impactan la salud mental y su relevancia respecto del desempeño académico de alumnos de administración y con...

  14. Melanopsin Gene Variations Interact With Season to Predict Sleep Onset and Chronotype

    OpenAIRE

    Roecklein, Kathryn A.; Wong, Patricia M.; Franzen, Peter L.; Hasler, Brant P.; Wood-Vasey, W. Michael; Nimgaonkar, Vishwajit L.; Miller, Megan A.; Kepreos, Kyle M.; Ferrell, Robert E.; Manuck, Stephen B.

    2012-01-01

    The human melanopsin gene has been reported to mediate risk for seasonal affective disorder (SAD), which is hypothesized to be caused by decreased photic input during winter when light levels fall below threshold, resulting in differences in circadian phase and/or sleep. However, it is unclear if melanopsin increases risk of SAD by causing differences in sleep or circadian phase, or if those differences are symptoms of the mood disorder. To determine if melanopsin sequence variations are asso...

  15. Benchmarking nacional e internacional de programas académicos de especialización en gerencia de proyectos

    OpenAIRE

    2013-01-01

    Presenta el estado actual de la formación en programas académicos de especialización en gerencia de proyectos y afines, a nivel regional, nacional e internacional; desde una perspectiva global, antes que discriminatoria de la situación actual por países o continentes, bajo una alternativa metodológica, sistemática y rigurosa; que permita orientar, considerando las especificidades académicas, institucionales y regionales de las instituciones de educación superior, los (re)diseños curriculares ...

  16. O virtual e os novos paradigmas da publicação acadêmica

    Directory of Open Access Journals (Sweden)

    Renato Nunes Bittencourt

    2012-02-01

    Full Text Available O presente artigo analisa as vantagens técnicas das publicações acadêmicas realizadas pelo suporte virtual, em decorrência da dinamicidade das interações intelectuais próprias da dimensão da Internet. Através do enfoque teórico de Pierre Lévy, um dos principais filósofos da dita “Cibercultura”, apresentamos as mudanças de perspectivas epistemológicas operadas pela difusão planetária da Internet e de que maneira tal transformação influenciou no processo de editoração dos periódicos acadêmicos, envolvendo de forma mais precisa a participação plena da comunidade intelectual em torno do processo de realização do veículo de difusão de conhecimento.

  17. Prevalence of variations in melanoma susceptibility genes among Slovenian melanoma families

    Directory of Open Access Journals (Sweden)

    Besic Nikola

    2008-09-01

    Full Text Available Abstract Background Two high-risk genes have been implicated in the development of CM (cutaneous melanoma. Germline mutations of the CDKN2A gene are found in CDK4 gene reported to date. Beside those high penetrance genes, certain allelic variants of the MC1R gene modify the risk of developing the disease. The aims of our study were: to determine the prevalence of germline CDKN2A mutations and variants in members of families with familial CM and in patients with multiple primary CM; to search for possible CDK4 mutations, and to determine the frequency of variations in the MC1R gene. Methods From January 2001 until January 2007, 64 individuals were included in the study. The group included 28 patients and 7 healthy relatives belonging to 25 families, 26 patients with multiple primary tumors and 3 children with CM. Additionally 54 healthy individuals were included as a control group. Mutations and variants of the melanoma susceptibility genes were identified by direct sequencing. Results Seven families with CDKN2A mutations were discovered (7/25 or 28.0%. The L94Q mutation found in one family had not been previously reported in other populations. The D84N variant, with possible biological impact, was discovered in the case of patient without family history but with multiple primary CM. Only one mutation carrier was found in the control group. Further analysis revealed that c.540C>T heterozygous carriers were more common in the group of CM patients and their healthy relatives (11/64 vs. 2/54. One p14ARF variant was discovered in the control group and no mutations of the CDK4 gene were found. Most frequently found variants of the MC1R gene were T314T, V60L, V92M, R151C, R160W and R163Q with frequencies slightly higher in the group of patients and their relatives than in the group of controls, but the difference was statistically insignificant. Conclusion The present study has shown high prevalence of p16INK4A mutations in Slovenian population of

  18. Académica Maria Mélida Durán Merchán - Académico Miguel Trias Fargas

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2000-08-01

    Full Text Available

    MARÍA MÉLIDA DURÁN

    Una de las secciones especialmente nostálgicas pero a su vez más trascendentales es esta de Obituarios en la revista “Medicina”. Acostumbra ser uno de los nichos literarios de la prolífica y versátil pluma del Académico Efraím Otero o de la pulida pero algo menos abundante del también Académico Zoilo Cuéllar.

    Puede ser esta sección de igual manera la semilla biográfica para aquellos ilustres médicos colombianos que por esta Institución pasaron, que llamamos “necrológica”, para darle un toque menos fúnebre y más alegre, pues destaca lo mucho de positivo que tuvo la vida de quien se escribe.

    Nos duele hacerlo hoy sobre María Mélida Durán Merchán, a quien me costó trabajo dejar de decirle “de Rueda”, en referencia a su compañero de tantas luchas y padre de su hijo Marcelo, el urólogo de Marly, Manuel Rueda Salazar.

    Y repito que siento consternación al hacerlo pues su edad distaba mucho de la de aquel personaje a quien se refería el Académico Laurentino Muñoz al conversar con su amigo Germán Arciniegas, un par de intelectuales a quienes la senectud no quitó vitalidad alguna. Vio pasar a algún conocido que rondaba en los cien años y dijo: “¿no es ese el que murió el año pasado?”...

    MIGUEL TRIAS FARGAS

    Nacido en Barcelona, Cataluña, el 9 de agosto de 1924, llegó el doctor Trías a Colombia a muy corta edad; se graduó como médico en la Universidad Nacional de Colombia y se especializó en Cirugía del Tórax en importantes instituciones de Inglaterra y Francia.

    Ejerció con brillo dicha especialidad en los Hospitales San Carlos, Santa Clara y San José de la ciudad de Bogotá, así como en la Fundación Shaio, a cuyo nacimiento contribuyó. Su trascendental labor en la Asociación Pro Bienestar de la Familia Colombiana, Profamilia, que dirigió desde 1973 hasta 1994, y en la Fundación Pro Derecho a

  19. Differentially expressed genes linked to natural variation in long-term memory formation in Cotesia parasitic wasps

    Directory of Open Access Journals (Sweden)

    Joke J. F. A. Van Vugt

    2015-09-01

    Full Text Available Even though learning and memory are universal traits in the Animal Kingdom, closely related species reveal substantial variation in learning rate and memory dynamics. To determine the genetic background of this natural variation, we studied two congeneric parasitic wasp species, Cotesia glomerata and C. rubecula, which lay their eggs in caterpillars of the large and small cabbage white butterfly. A successful egg laying event serves as an unconditioned stimulus in a classical conditioning paradigm, where plant odors become associated to the encounter of a suitable host caterpillar. Depending on the host species, the number of conditioning trials and the parasitic wasp species, three different types of transcription-dependent long-term memory (LTM and one type of transcription-independent, anesthesia-resistant memory (ARM can be distinguished. To identify transcripts underlying these differences in memory formation, we isolated mRNA from parasitic wasp heads at three different time points between induction and consolidation of each of the four memory types, and for each sample three biological replicates, where after strand-specific paired-end 100 bp deep sequencing. Transcriptomes were assembled de novo and differential expression was determined for each memory type and time point after conditioning, compared to unconditioned wasps. Most differentially expressed (DE genes and antisense transcripts were only DE in one of the LTM types. Among the DE genes that were DE in two or more LTM types, were many protein kinases and phosphatases, small GTPases, receptors and ion channels. Some genes were DE in opposing directions between any of the LTM memory types and ARM, suggesting that ARM in Cotesia requires the transcription of genes inhibiting LTM or vice versa. We discuss our findings in the context of neuronal functioning, including RNA splicing and transport, epigenetic regulation, neurotransmitter/peptide synthesis and antisense transcription. In

  20. Variation in the γ-glutamyltransferase 1 gene and risk of chronic pancreatitis.

    Science.gov (United States)

    Brand, Harrison; Diergaarde, Brenda; O'Connell, Michael R; Whitcomb, David C; Brand, Randall E

    2013-07-01

    Individuals with chronic pancreatitis are at increased risk for pancreatic cancer. We hypothesized that genetic variation in the γ-glutamyltransferase 1 (GGT1) gene, which was recently reported associated with pancreatic cancer risk in a genome-wide association study, is also associated with risk of chronic pancreatitis. Associations between common polymorphisms in GGT1 and chronic pancreatitis were evaluated using data and samples from the North American Pancreatitis Study 2. Patients (n = 496) and control subjects (n = 465) were genotyped for 4 single-nucleotide polymorphisms: rs4820599, rs2017869, rs8135987, and rs5751901. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) for chronic pancreatitis risk were calculated using multiple logistic regression models. Interactions with cigarette smoking and alcohol use were explored. Single-nucleotide polymorphisms rs8135987 and rs4820599 were both statistically significantly associated with risk of chronic pancreatitis; compared with common allele homozygotes, individuals with at least 1 minor allele were at increased risk (rs8135987: OR, 1.36; 95% CI, 1.03-1.80 [P(trend) = 0.01]; rs4820599: OR, 1.39; 95% CI, 1.04-1.84 [P(trend) = 0.0]; adjusted for age, sex, race, smoking status, and alcohol use). No significant interactions with cigarette smoking and alcohol use were observed. Our results suggest that common variation in the GGT1 gene may also affect risk of chronic pancreatitis.

  1. Analysis of Temporal-spatial Co-variation within Gene Expression Microarray Data in an Organogenesis Model

    Science.gov (United States)

    Ehler, Martin; Rajapakse, Vinodh; Zeeberg, Barry; Brooks, Brian; Brown, Jacob; Czaja, Wojciech; Bonner, Robert F.

    The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. We used a novel clustering method based on Laplacian Eigenmaps, a nonlinear dimension reduction method, to analyze microarray data from laser capture microdissected (LCM) cells at the site and developmental stages (days 10.5 to 12.5) of optic fissure closure. Our new method provided greater biological specificity than classical clustering algorithms in terms of identifying more biological processes and functions related to eye development as defined by Gene Ontology at lower false discovery rates. This new methodology builds on the advantages of LCM to isolate pure phenotypic populations within complex tissues and allows improved ability to identify critical gene products expressed at lower copy number. The combination of LCM of embryonic organs, gene expression microarrays, and extracting spatial and temporal co-variations appear to be a powerful approach to understanding the gene regulatory networks that specify mammalian organogenesis.

  2. Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample

    Energy Technology Data Exchange (ETDEWEB)

    Lind, Lars [Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala (Sweden); Penell, Johanna [Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala (Sweden); Syvänen, Anne-Christine; Axelsson, Tomas [Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala (Sweden); Ingelsson, Erik [Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala (Sweden); Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford (United Kingdom); Morris, Andrew P.; Lindgren, Cecilia [Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford (United Kingdom); Salihovic, Samira; Bavel, Bert van [MTM Research Centre, School of Science and Technology, Örebro University, Örebro (Sweden); Lind, P. Monica, E-mail: monica.lind@medsci.uu.se [Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala (Sweden)

    2014-08-15

    Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. We evaluated if circulating levels of PCBs in a population sample were related to genetic variation in the genes encoding these CYPs. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), 21 SNPs in the CYP1A1, CYP1A2 and CYP1B1 genes were genotyped. Sixteen PCB congeners were analysed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS). Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). However, there were several additional SNPs in the CYP1A2 and CYP1B1 that showed nominally significant associations with PCB118 levels (p-values in the 0.003–0.05 range). Further, several SNPs in the CYP1B1 gene were related to both PCB156 and PCB206 with p-values in the 0.005–0.05 range. Very few associations with p<0.05 were seen for PCB126, PCB169 or PCB170. Genetic variation in the CYP1A1 was related to circulating PCB118 levels in the general elderly population. Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs. - Highlights: • We studied the relationship between PCBs and the genetic variation in the CYP genes. • Cross sectional data from a cohort of elderly were analysed. • The PCB levels were evaluated versus 21 SNPs in three CYP genes. • PCB 118 was related to variation in the CYP1A1 gene.

  3. Sobre el plagi acadèmic a Europa. Un enfocament analític basat en quatre estudis

    Directory of Open Access Journals (Sweden)

    Vanja Pupovac

    2008-12-01

    Full Text Available Amb el desenvolupament de les tecnologies de la informació i la comunicació (TIC, el plagi esdevé un problema cada cop més greu en la comunitat acadèmica. Segons els estudis sobre el plagi acadèmic elaborats en universitats de quatre països europeus diferents, l'índex de plagi entre els estudiants és considerablement alt i els estudiants majoritàriament passen per alt o permeten el plagi per la manca de coneixement, la manca de conseqüències o simplement perquè les TIC fan que el plagi sigui fàcil de cometre. Les conclusions dels estudis que es presenten en aquest article indiquen que cal introduir polítiques estrictes contra el plagi a les universitats. Pensem que s'hauria de captar l'atenció del públic sobre el problema del plagi, que s'hauria de debatre en altes esferes i que s'haurien d'aplicar mesures efectives contra el plagi. L'abast del plagi entre estudiants i les seves actituds envers el plagi reben influències de l'entorn cultural i també per l'escenari acadèmic. En comunitats multiculturals, com ara la comunitat europea, és necessari investigar i comparar el comportament acadèmic a diferents països per a establir estàndards equivalents en l'ensenyament arreu d'Europa. Text complet (PDFDossier complet (PDF

  4. [Variation of CAG repeats in coding region of ATXN2 gene in different ethnic groups].

    Science.gov (United States)

    Chen, Xiao-Chen; Sun, Hao; Mi, Dong-Qing; Huang, Xiao-Qin; Lin, Ke-Qin; Yi, Wen; Yu, Liang; Shi, Lei; Shi, Li; Yang, Zhao-Qing; Chu, Jia-You

    2011-04-01

    Toinvestigate CAG repeats variation of ATXN2 gene coding region in six ethnic groups that live in comparatively different environments, to evaluate whether these variations are under positive selection, and to find factors driving selection effects, 291 unrelated healthy individuals were collected from six ethnic groups and their STR geneotyping was performed. The frequencies of alleles and genotypes were counted and thereby Slatkin's linearized Fst values were calculated. The UPGMA tree against this gene was constructed. The MDS analysis among these groups was carried out as well. The results from the linearized Fst values indicated that there were significant evolutionary differences of the STR in ATXN2 gene between Hui and Yi groups, but not among the other 4 groups. Further analysis was performed by combining our data with published data obtained from other groups. These results indicated that there were significant differences between Japanese and other groups including Hui, Hani, Yunnan Mongolian, and Inner Mongolian. Both Hui and Mongolian from Inner Mongolia were significantly different from Han. In conclusion, the six ethnic groups had their own distribution characterizations of allelic frequencies of ATXN2 STR, and the potential cause of frequency changes in rare alleles could be the consequence of positive selection.

  5. Natural variation and gene regulatory basis for the responses of asparagus beans to soil drought

    Directory of Open Access Journals (Sweden)

    Pei eXu

    2015-10-01

    Full Text Available Asparagus bean (Vigna unguiculata ssp. sesquipedalis is the Asian subspecies of cowpea, a drought-resistant legume crop native to Africa. In order to explore the genetic variation of drought responses in asparagus bean, we conducted multi-year phenotyping of drought resistance traits across the Chinese asparagus bean mini-core. The phenotypic distribution indicated that the ssp. sesquipedalis subgene pool has maintained high natural variation in drought responses despite known domestic bottleneck. Thirty-nine SNP loci were found to show an association with drought resistance via a genome-wide association study (GWAS. Whole-plant water relations were compared among four genotypes by lysimetric assay. Apparent genotypic differences in transpiration patterns and the critical soil water threshold in relation to dehydration avoidance were observed, indicating a delicate adaptive mechanism for each genotype to its own climate. Microarray gene expression analyses revealed that known drought resistance pathways such as the ABA and phosphate lipid signaling pathways are conserved between genotypes, while differential regulation of certain aquaporin genes and hormonal genes may be important for the genotypic differences. Our results suggest that divergent sensitivity to soil water content is an important mechanism configuring the genotypic specific responses to water deficit. The SNP markers identified provide useful resources for marker-assisted breeding.

  6. Natural variation and gene regulatory basis for the responses of asparagus beans to soil drought

    Science.gov (United States)

    Xu, Pei; Moshelion, Menachem; Wu, XiaoHua; Halperin, Ofer; Wang, BaoGen; Luo, Jie; Wallach, Rony; Wu, Xinyi; Lu, Zhongfu; Li, Guojing

    2015-01-01

    Asparagus bean (Vigna unguiculata ssp. sesquipedalis) is the Asian subspecies of cowpea, a drought-resistant legume crop native to Africa. In order to explore the genetic variation of drought responses in asparagus bean, we conducted multi-year phenotyping of drought resistance traits across the Chinese asparagus bean mini-core. The phenotypic distribution indicated that the ssp. sesquipedalis subgene pool has maintained high natural variation in drought responses despite known domestic bottleneck. Thirty-nine SNP loci were found to show an association with drought resistance via a genome-wide association study (GWAS). Whole-plant water relations were compared among four genotypes by lysimetric assay. Apparent genotypic differences in transpiration patterns and the critical soil water threshold in relation to dehydration avoidance were observed, indicating a delicate adaptive mechanism for each genotype to its own climate. Microarray gene expression analyses revealed that known drought resistance pathways such as the ABA and phosphate lipid signaling pathways are conserved between different genotypes, while differential regulation of certain aquaporin genes and hormonal genes may be important for the genotypic differences. Our results suggest that divergent sensitivity to soil water content is an important mechanism configuring the genotypic specific responses to water deficit. The SNP markers identified provide useful resources for marker-assisted breeding. PMID:26579145

  7. El papel de la procrastinación académica como factor de la deserción universitaria

    Directory of Open Access Journals (Sweden)

    Angélica Garzón Umerenkova

    2017-01-01

    Full Text Available Se presenta una revisión teórica sobre las tendencias en el estudio de la procrastinación académica y lo que estas pueden ofrecer a la comprensión de la deserción universitaria. La procrastinación es aplazar aquello que debe ser hecho y está asociado con un fallo auto-regulatorio en el comportamiento de la gestión del tiempo. Inicialmente, se define qué es la deserción universitaria, las variables y modelos teóricos de los que se ha partido para su explicación y se presentan las principales cifras sobre deserción y cobertura universitarias. Posteriormente, se presentan los modelos de autorregulación académica desde los cuales se ha abordado el estudio de la procrastinación y, finalmente, se definen los principales hallazgos y perspectivas de intervención sobre la procrastinación. Para fomentar el aumento de la retención, es conveniente, además del estudio de las variables tradicionales asociadas a la deserción universitaria, incorporar nuevas variables que aporten elementos conceptuales a la explicación y prevención del fenómeno. Este es el caso de la procrastinación académica. Se muestra en este documento que hay evidencias de la asociación entre alta procrastinación y bajo rendimiento académico de los estudiantes, que es una competencia que se puede evaluar en los procesos de entrada a la universidad, que es posible entrenarla con éxito y que su mejora, abordada dentro del contexto del aprendizaje autorregulado, acarrea no sólo beneficios académicos sino que también ayuda a mejorar la calidad de vida de los estudiantes.

  8. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

    KAUST Repository

    Phelan, Jody E.

    2016-02-29

    Background Approximately 10 % of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies. Results To elucidate the structure of these genes, 518 genomes from a diverse international collection of clinical isolates were de novo assembled. A further 21 reference M. tuberculosis complex genomes and long read sequence data were used to validate the approach. SNP analysis revealed that variation in the majority of the 168 pe/ppe genes studied was consistent with lineage. Several recombination hotspots were identified, notably pe_pgrs3 and pe_pgrs17. Evidence of positive selection was revealed in 65 pe/ppe genes, including epitopes potentially binding to major histocompatibility complex molecules. Conclusions This, the first comprehensive study of the pe and ppe genes, provides important insight into M. tuberculosis diversity and has significant implications for vaccine development.

  9. Characterization of genomic variations in SNPs of PE_PGRS genes reveals deletions and insertions in extensively drug resistant (XDR) M. tuberculosis strains from Pakistan

    KAUST Repository

    Kanji, Akbar; Hasan, Zahra; Ali, Asho; McNerney, Ruth; Mallard, Kim; Coll, Francesc; Hill-Cawthorne, Grant A.; Nair, Mridul; Clark, Taane G.; Zaver, Ambreen; Jafri, Sana; Hasan, Rumina

    2015-01-01

    Genetic diversity in PE_PGRS genes contributes to antigenic variability and may result in increased immunogenicity of strains. This is the first study identifying variations in nsSNPs and INDELs in the PE_PGRS genes of XDR-TB strains from Pakistan. It highlights common genetic variations which may contribute to persistence.

  10. Discurso de Orden Pronunciado por el Académico Dr. Efraím Otero-Ruiz, durante la posesión del Académico.

    Directory of Open Access Journals (Sweden)

    Victoria Rodriguez

    1998-12-01

    Full Text Available

    Dr. José Félix Patiño como Presidente de la Academia Nacional de Medicina.

    Señores Académicos, señoras, señores:

    (Santafé de Bogotá, marzo 19 de 1998


    Como un "Fenómeno del Niño" y con el ímpetu emocional de esas sagas cíclicas que nos recordara
    vívidamente "Cien Años de Soledad" se repite, a los ocho años, una ceremonia en que dos de sus
    actores son los mismos, sólo que con orden inverso. Esta vez un hombre salido de las filas académicas, sin otro mérito que su capacidad de reconocimiento y afecto, tiene como honroso encargo pronunciar el discurso de orden en la posesión de José Félix Patiño como Presidente de la Academia Nacional de Medicina para los dos últimos años del milenio, rodeado de una dignísima Junta Directiva y sucediendo a otro hombre de cualidades eximias, que ha dirigido uno de los cuatrienios más ilustres por
    los que haya pasado la corporación.

    En esa otra época, 1990, fue un académico ya cargado de honores y de merecimientos quien pronunciara gallardamente el discurso de orden durante el acto de mi posesión como Presidente, en el paraninfo de la Academia Colombiana de la Lengua.
    Denominador común era y sigue siendo el mutuo bagaje de una amistad ininterrumpida de más de
    cuarenta años, que es el que me lleva a pronunciar estas palabras, cargadas como nunca de admiración, de respeto y de cariño.

    Porque la nutrida votación que llevó al académico Patiño a salir electo con el 95% de los votos,
    fenómeno casi nunca antes visto en los anales de nuestra venerable Academia, no es sino la expresión
    unánime de confianza por un hombre que, ya alcanzada la "edad bíblica" --como él mismo
    lo dijera en sus vivaces memorias del año pasado- conserva la chispa de su infatigable intelecto,
    siempre ávido para enseñar y aprender; y mantiene la integridad física y el ánimo del cirujano de

  11. A general scenario of Hox gene inventory variation among major sarcopterygian lineages

    Directory of Open Access Journals (Sweden)

    Wang Chaolin

    2011-01-01

    Full Text Available Abstract Background Hox genes are known to play a key role in shaping the body plan of metazoans. Evolutionary dynamics of these genes is therefore essential in explaining patterns of evolutionary diversity. Among extant sarcopterygians comprising both lobe-finned fishes and tetrapods, our knowledge of the Hox genes and clusters has largely been restricted in several model organisms such as frogs, birds and mammals. Some evolutionary gaps still exist, especially for those groups with derived body morphology or occupying key positions on the tree of life, hindering our understanding of how Hox gene inventory varied along the sarcopterygian lineage. Results We determined the Hox gene inventory for six sarcopterygian groups: lungfishes, caecilians, salamanders, snakes, turtles and crocodiles by comprehensive PCR survey and genome walking. Variable Hox genes in each of the six sarcopterygian group representatives, compared to the human Hox gene inventory, were further validated for their presence/absence by PCR survey in a number of related species representing a broad evolutionary coverage of the group. Turtles, crocodiles, birds and placental mammals possess the same 39 Hox genes. HoxD12 is absent in snakes, amphibians and probably lungfishes. HoxB13 is lost in frogs and caecilians. Lobe-finned fishes, amphibians and squamate reptiles possess HoxC3. HoxC1 is only present in caecilians and lobe-finned fishes. Similar to coelacanths, lungfishes also possess HoxA14, which is only found in lobe-finned fishes to date. Our Hox gene variation data favor the lungfish-tetrapod, turtle-archosaur and frog-salamander relationships and imply that the loss of HoxD12 is not directly related to digit reduction. Conclusions Our newly determined Hox inventory data provide a more complete scenario for evolutionary dynamics of Hox genes along the sarcopterygian lineage. Limbless, worm-like caecilians and snakes possess similar Hox gene inventories to animals with

  12. Sequence Variation in Rhoptry Neck Protein 10 Gene among Toxoplasma gondii Isolates from Different Hosts and Geographical Locations

    Directory of Open Access Journals (Sweden)

    Yu ZHAO

    2017-09-01

    Full Text Available Background: Toxoplasma gondii, as a eukaryotic parasite of the phylum Apicomplexa, can infect almost all the warm-blooded animals and humans, causing toxoplasmosis. Rhoptry neck proteins (RONs play a key role in the invasion process of T. gondii and are potential vaccine candidate molecules against toxoplasmosis.Methods: The present study examined sequence variation in the rhoptry neck protein 10 (TgRON10 gene among 10 T. gondii isolates from different hosts and geographical locations from Lanzhou province during 2014, and compared with the corresponding sequences of strains ME49 and VEG obtained from the ToxoDB database, using polymerase chain reaction (PCR amplification, sequence analysis, and phylogenetic reconstruction by Bayesian inference (BI and maximum parsimony (MP. Results: Analysis of all the 12 TgRON10 genomic and cDNA sequences revealed 7 exons and 6 introns in the TgRON10 gDNA. The complete genomic sequence of the TgRON10 gene ranged from 4759 bp to 4763 bp, and sequence variation was 0-0.6% among the 12 T. gondii isolates, indicating a low sequence variation in TgRON10 gene. Phylogenetic analysis of TgRON10 sequences showed that the cluster of the 12 T. gondii isolates was not completely consistent with their respective genotypes.Conclusion: TgRON10 gene is not a suitable genetic marker for the differentiation of T. gondii isolates from different hosts and geographical locations, but may represent a potential vaccine candidate against toxoplasmosis, worth further studies.

  13. Sequence Variation in Rhoptry Neck Protein 10 Gene among Toxoplasma gondii Isolates from Different Hosts and Geographical Locations.

    Science.gov (United States)

    Zhao, Yu; Zhou, Donghui; Chen, Jia; Sun, Xiaolin

    2017-01-01

    Toxoplasma gondii, as a eukaryotic parasite of the phylum Apicomplexa, can infect almost all the warm-blooded animals and humans, causing toxoplasmosis. Rhoptry neck proteins (RONs) play a key role in the invasion process of T. gondii and are potential vaccine candidate molecules against toxoplasmosis. The present study examined sequence variation in the rhoptry neck protein 10 (TgRON10) gene among 10 T. gondii isolates from different hosts and geographical locations from Lanzhou province during 2014, and compared with the corresponding sequences of strains ME49 and VEG obtained from the ToxoDB database, using polymerase chain reaction (PCR) amplification, sequence analysis, and phylogenetic reconstruction by Bayesian inference (BI) and maximum parsimony (MP). Analysis of all the 12 TgRON10 genomic and cDNA sequences revealed 7 exons and 6 introns in the TgRON10 gDNA. The complete genomic sequence of the TgRON10 gene ranged from 4759 bp to 4763 bp, and sequence variation was 0-0.6% among the 12 T. gondii isolates, indicating a low sequence variation in TgRON10 gene. Phylogenetic analysis of TgRON10 sequences showed that the cluster of the 12 T. gondii isolates was not completely consistent with their respective genotypes. TgRON10 gene is not a suitable genetic marker for the differentiation of T. gondii isolates from different hosts and geographical locations, but may represent a potential vaccine candidate against toxoplasmosis, worth further studies.

  14. Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut.

    Directory of Open Access Journals (Sweden)

    Vincent Raquin

    2017-12-01

    Full Text Available Dengue virus (DENV causes more human infections than any other mosquito-borne virus. The current lack of antiviral strategies has prompted genome-wide screens for host genes that are required for DENV infectivity. Earlier transcriptomic studies that identified DENV host factors in the primary vector Aedes aegypti used inbred laboratory colonies and/or pools of mosquitoes that erase individual variation. Here, we performed transcriptome sequencing on individual midguts in a field-derived Ae. aegypti population to identify new candidate host factors modulating DENV replication. We analyzed the transcriptomic data using an approach that accounts for individual co-variation between viral RNA load and gene expression. This approach generates a prediction about the agonist or antagonist effect of candidate genes on DENV replication based on the sign of the correlation between gene expression and viral RNA load. Using this method, we identified 39 candidate genes that went undetected by conventional pairwise comparison of gene expression levels between DENV-infected midguts and uninfected controls. Only four candidate genes were detected by both methods, emphasizing their complementarity. We demonstrated the value of our approach by functional validation of a candidate agonist gene encoding a sterol regulatory element-binding protein (SREBP, which was identified by correlation analysis but not by pairwise comparison. We confirmed that SREBP promotes DENV infection in the midgut by RNAi-mediated gene knockdown in vivo. We suggest that our approach for transcriptomic analysis can empower genome-wide screens for potential agonist or antagonist factors by leveraging inter-individual variation in gene expression. More generally, this method is applicable to a wide range of phenotypic traits displaying inter-individual variation.

  15. Características psicológicas y desempeño académico en universitarios de profesiones de pronta ocupación

    OpenAIRE

    Riveros, Angélica; Rubio, Tomás Humberto; Candelario, Julieta; Mangín, Mariana

    2013-01-01

    El rendimiento académico hace evidentes contrastes entre las condiciones que enfrentan los alumnos y estados de bienestar y malestar psicológico. En México las principales razones de la deserción escolar son económicas, la necesidad de la inserción temprana en el campo laboral y bajo desempeño académico. El propósito del presente trabajo fue identificar los factores que impactan la salud mental y su relevancia respecto del desempeño académico de alumnos de administración y contaduría de la Un...

  16. LAS AULAS DE ACOMPAÑAMIENTO ACADÉMICO: Soporte de Aprendizaje e Integración Académica en la Pontificia Universidad Javeriana.

    OpenAIRE

    Ordóñez Torres, Costanza; Jaramillo Correa, Carolina

    2017-01-01

    Las Aulas de Acompañamiento Académico implementadas en la Pontificia Universidad Javeriana desde el año 2016 son una de las estrategias de la Universidad encaminadas a fortalecer el rendimiento académico de los estudiantes en áreas básicas, a disminuir las tasas de deserción producto del fracaso académico y a propender por la apropiación de conocimientos y competencias que asegurarían los aprendizajes en áreas más complejas. Esta presentación se centrará en los factores asociados al fenómeno ...

  17. Estrategias de aprendizaje y rendimiento académico en una Institución Educativa de Magdalena 2014

    OpenAIRE

    Viaña Frit, Carmen Cecilia

    2015-01-01

    La investigación titulada, “Uso de las estrategias de aprendizaje y el rendimiento académico de los estudiantes del VII ciclo del nivel secundaria de la I.E. Francisco Bolognesi de Magdalena 2014”, cuyo objetivo fue determinar la relación que existe entre el uso de las estrategias de aprendizaje y el rendimiento académico de los estudiantes del VII ciclo del nivel secundaria de la I.E. Francisco Bolognesi de Magdalena 2014, como un aporte al análisis, descripción y explicación ...

  18. Variations in KIR Genes: A Study in HIV-1 Serodiscordant Couples

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    Vijay R. Chavan

    2014-01-01

    Full Text Available Background. NK cells have anti-HIV activity mediated through killer cell immunoglobulin-like receptors (KIRs. The current prospective cohort study evaluated whether variation in KIR genes is associated with HIV infection in discordant couples (DCs, where one spouse remains seronegative (HSN despite repeated exposure to the HIV. Methods. KIR was genotyped using PCR SSP. Viral load and CD4 counts were estimated using commercially available reagents. Data were analyzed using SPSS software. Results. Among the 47 DCs, HSN spouses had significantly (P=0.006 higher frequencies of KIR3DS1. Regression analysis revealed significant (P=0.009 association of KIR2DS1 with low viral load. KIR2DS4 variant was associated (P=0.032 with high viral load. Three pairs of KIR genes were in strong LD in HSNs and two pairs in HSPs. There were 60 KIR genotypes, and 16 are reported the first time in the Indian population. Exclusive genotypes were present either in HSPs (N=22, 11 unique genotypes or in HSNs (n=27, 9 unique genotypes. Conclusions. This study highlights for the first time in the Indian population an association of KIR genes in HIV infection where presence of exclusive and unique genotypes indicates possible association with either HIV infection or with protection.

  19. La trascendencia del logos universitario: diálogo educativo/ diálogo académico

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    Gustavo A. Segura-Lazcano

    2016-01-01

    Full Text Available A partir de la propuesta hermenéutica de Hans-Georg Gadamer, se reflexionó sobre la trascendencia de los diálogos educativo y académico en el ámbito universitario. Se puso énfasis en el intercambio de argumentos como elemento que instaura y renueva el sentido humanista y científico de la sociedad académica, y al mismo tiempo confiere a sus miembros identidad, legitimidad y presencia histórica. Finalmente, se dio cuenta de la importancia del debate cotidiano de nociones y concepciones entre investigadores, profesores y alumnos, para configurar una comunidad plural, defensora de la libertad de pensamiento y consciente de los modelos que sustentan sus interpretaciones.

  20. The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

    DEFF Research Database (Denmark)

    Hornbak, Malene; Banasik, Karina; Justesen, Johanne Marie

    2011-01-01

    -aged Danish individuals (nACADS=4,324; nACADM=4,337). The T2D-case-control study involved a total of ~8,300 Danish individuals (nACADS=8,313; nACADM=8,344). Results In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS associated with reduced measures of serum insulin at 30 min following...... an oral glucose load (per allele effect (beta)=-3.8% (-6.3%;-1.3%), P=0.003), reduced incremental area under the insulin curve (beta=-3.6% (-6.3%;-0.9%), P=0.009), reduced acute insulin response (beta=-2.2% (-4.2%;0.2%), P=0.03), and with increased insulin sensitivity ISIMatsuda (beta= 2.9% (0.5%;5.2%), P...

  1. Letramento acadêmico: uma perspectiva etramento portuguesa = Academic literacy: a Portuguese perspective

    Directory of Open Access Journals (Sweden)

    Adriana Fischer

    2008-07-01

    Full Text Available Os modos de constituição letrada de alunos universitários, no meio acadêmico, é foco deste trabalho, realizado em Portugal, no ano de 2006. Os dados que integram as análises advêm de entrevistas orais semiestruturadas realizadas com alunos do curso de Letras da Universidade do Minho. São selecionadas as falas de quatro alunas, a fim de se proceder a discussões específicas e coerentes ao objetivo proposto: analisar como alunos constituem-se sujeitos letrados no meio acadêmico. A teoria do letramento como prática social direciona as discussões e análises dos resultados advindos das falas vivas das alunas. Em acréscimo, abordagens relativas ao letramento acadêmico são decisivas para a compreensão das práticas letradas nesse contexto social. Na perspectiva das quatro alunas/sujeitos da pesquisa, experiências anteriores ao ingresso no curso de Letras e,principalmente, as diversas formas de interação no meio acadêmico interferem no uso, no domínio da linguagem e na formação como professoras. Das falas das alunas emerge uma tensão constante entre ser aluno e ser professor, o que indica uma constituição letrada emconflito, no que tange ao ensino de língua em Letras.Current analysis deals with modes of literate constituency of undergraduate students in an academic environment. Study hasbeen undertaken in Portugal in 2006. Data for analysis hailed from half-structured interviews with students in a Language and Literature graduation course at the University of Minho, Portugal. Samples of responses by four students were selected for specific discussions and with the proposed objective of this study, or rather, to analyze the way students constitute themselves as literate subjects in the academic environment. Literacy theory as social practice guided thediscussions and analyses of results from the interviews. Approaches related to academic literacy are crucial for the understanding of the literate practices in this social

  2. [Association of the genetic variations of bone morphogenetic protein 7 gene with diabetes and insulin resistance in Xinjiang Uygur population].

    Science.gov (United States)

    Yan, Zhi-tao; Li, Nan-fang; Guo, Yan-ying; Yao, Xiao-guang; Wang, Hong-mei; Hu, Jun-li

    2011-06-01

    To investigate the association between the genetic variations of the functional region in bone morphogenetic protein gene (BMP7) with type 2 diabetes mellitus in Chinese Uygur individuals. A case-control study was conducted based on epidemiological investigation. A total of 717 Uygur subjects (276 males and 441 females) were selected and divided into two groups: diabetes mellitus group (n = 502, 191 males and 311 females) and control group (n = 215, 85 males and 130 females). All exons, flanking introns and the promoter regions of (BMP7) gene were sequenced in 48 Uygur diabetics. Representative variations were selected according to the minor allele frequency (MAF) and linkage disequilibrium and genotyped using the TaqMan polymerase chain reaction method in 717 Uygur individuals, a relatively isolated general population in a relatively homogeneous environment and a case-control study was conducted to test the association between the genetic variations of (BMP7) gene and type 2 diabetes mellitus. Five novel and 8 known variations in the (BMP7) gene were identified. All genotype distributions were tested for deviations from Hardy-Weinberg equilibrium (P> 0.05). There was significant difference of genotype distribution of rs6025422 between type 2 diabetes mellitus and control groups in the male population (P 0.05), but there was no difference in total and female population (P> 0.05). And the means of fasting blood glucose (FBG), fasting insulin and HOMA-index significantly decreased in individuals with AA, AG and GG genotypes of rs6025422 in male population (Ppopulation (P> 0.05). The logistic regression analysis showed that GG genotype of rs6025422 variation might be a protective factor for diabetes in male (OR= 0.637, 95% confidence interval 0.439-0.923, P< 0.05). The present study suggests that the rs6025422 polymorphism in (BMP7) gene may be associated with diabetes mellitus and insulin resistance in Uygur men.

  3. Haplotypes and Sequence Variation in the Ovine Adiponectin Gene (ADIPOQ

    Directory of Open Access Journals (Sweden)

    Qing-Ming An

    2015-11-01

    Full Text Available The adiponectin gene (ADIPOQ plays an important role in energy homeostasis. In this study five separate regions (regions 1 to 5 of ovine ADIPOQ were analysed using PCR-SSCP. Four different PCR-SSCP patterns (A1-D1, A2-D2 were detected in region-1 and region-2, respectively, with seven and six SNPs being revealed. In region-3, three different patterns (A3-C3 and three SNPs were observed. Two patterns (A4-B4, A5-B5 and two and one SNPs were observed in region-4 and region-5, respectively. In total, nineteen SNPs were detected, with five of them in the coding region and two (c.46T/C and c.515G/A putatively resulting in amino acid changes (p.Tyr16His and p.Lys172Arg. In region-1, -2 and -3 of 316 sheep from eight New Zealand breeds, variants A1, A2 and A3 were the most common, although variant frequencies differed in the eight breeds. Across region-1 and region-3, nine haplotypes were identified and haplotypes A1-A3, A1-C3, B1-A3 and B1-C3 were most common. These results indicate that the ADIPOQ gene is polymorphic and suggest that further analysis is required to see if the variation in the gene is associated with animal production traits.

  4. Estilos educativos parentais, autoconceito e desempenho académico

    OpenAIRE

    Satúrio-Pires, Catarina de Almeida de

    2009-01-01

    Dissertação de mestrado apresentada ao ISPA -Instituto Superior Dando uso a diversas questões psicossociais que debatem as consequências dos padrões actuais de educação dos pais relativamente aos seus filhos, este trabalho tem por objectivo aferir de que forma os estilos educativos parentais (autoritário, autoritativo, permissivo e negligente) tal como percebidos por pais e filhos, influenciam as diferentes dimensões do autoconceito e o desempenho académico das crianças. Para o efeito, foi...

  5. Treinamento desportivo: perfil acadêmico dos líderes de grupos de estudo brasileiros

    Directory of Open Access Journals (Sweden)

    Hudson Fabricius Peres Nunes

    Full Text Available Resumo Este estudo objetivou caracterizar o perfil acadêmico dos professores líderes de grupos de estudo brasileiros que desenvolvem pesquisas na subárea de treinamento desportivo. A metodologia usada foi a pesquisa descritiva dos currículos acadêmicos encontrados no banco de dados da Plataforma Lattes, tendo em vista que os dados quantitativos foram interpretados a partir da análise qualitativa das informações. Os resultados revelam que os grupos estão vinculados principalmente a universidades da Região Sudeste, a maioria dos líderes é doutor e a prevalência da produção científica está relacionada à preparação orgânica, pedagógica, psicológica e desportiva dos atletas.

  6. The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide.

    Science.gov (United States)

    Zouk, Hana; McGirr, Alexander; Lebel, Véronique; Benkelfat, Chawky; Rouleau, Guy; Turecki, Gustavo

    2007-12-05

    Impulsive-aggressive behaviors (IABs) are regarded as possible suicide intermediate phenotypes, mediating the relationship between genes and suicide outcome. In this study, we aimed to investigate the putative relationship between genetic variation at the 5-HT1B receptor gene, which in animal models is involved in impulse-aggression control, IABs, and suicide risk. We investigated the relationship of variation at five 5-HT1B loci and IAB measures in a sample of 696 subjects, including 338 individuals who died by suicide and 358 normal epidemiological controls. We found that variation at the 5-HT1B promoter A-161T locus had a significant effect on levels of IABs, as measured by the Buss-Durkee Hostility Inventory (BDHI). Suicides also differed from controls in distribution of variants at this locus. The A-161T locus, which seems to impact 5-HT1B transcription, could play a role in suicide predisposition by means of mediating impulsive-aggressive behaviors. 2007 Wiley-Liss, Inc.

  7. Procrastinación en Estudiantes Universitarios: Su Relación con la Edad y el Curso Académico

    Directory of Open Access Journals (Sweden)

    Anna Rodríguez Camprubí

    2017-02-01

    Full Text Available El propósito de esta investigación es descubrir si la procrastinación académica disminuye a lo largo del tiempo, y si esta disminución se explica por el factor edad, por el factor curso, o por una combinación de ambas variables. Se administró la Procrastination Assessment Scale Students (pass a una muestra de 105 alumnos universitarios, que se dividieron en cuatro grupos independientes en función de si eran menores o mayores de 25 años y del curso académico que hacían. Los resultados indican que el nivel de procrastinación solo depende de la edad y no del curso de los alumnos, y amplían el conocimiento empírico sobre procrastinación académica en la universidad.

  8. Académico Joaquín Silva Silva (1917-2003

    Directory of Open Access Journals (Sweden)

    Zoilo Cuellar Montoya

    2003-06-01

    En 1984, la Escuela Milítar de Medicina lo exaltó a la honrosa categoría de Profesor Emérito y, de 1976 a 1994. la Asociación Colombiana de Facultades de Medicina (ASCOFAME lo tuvo como miembro de su Comité de Educación en Cirugía General. En 1989, durante la Presidencia del Académico Jorge Cavelier Gaviria, ingresó a la Academia Nacional de Medicina ...

  9. Estilo cognitivo y logro académico Estilo cognitivo e rendimento escolar Cognitive Style and Academic Achievement

    Directory of Open Access Journals (Sweden)

    Omar López-Vargas

    2011-04-01

    Full Text Available El presente trabajo tiene como objetivo explorar las relaciones entre el estilo cognitivo, el aprendizaje autorregulado y el logro académico, en diferentes niveles del proceso de aprendizaje. La revisión de la literatura especializada indica que existe una estrecha relación entre el estilo cognitivo del estudiante y la capacidad de regulación de su aprendizaje con el desempeño académico en general.Este artigo explora as relações entre estilo cognitivo, aprendizagem auto-regulada e rendimento escolar com diferentes níveis de aprendizagem. A revisão da literatura mostra uma relação estreita entre o estilo cognitivo do aluno e a capacidade de regular a sua aprendizagem com o desempenho acadêmico.The aim of this article is to explore the relationships that exist between cognitive style, self-regulated learning and academic achievement at different levels in the learning process. The review of specialized literature suggests there is a close relationship between academic performance in general and a student's cognitive style and ability to regulate learning.

  10. La edición electrónica y la gestión de trabajos académicos con Open Conference Systems (OCS

    Directory of Open Access Journals (Sweden)

    Javier J. MAQUILÓN SÁNCHEZ

    2011-01-01

    Full Text Available La red internet fomenta espacios virtuales para la interacción social y la participación abierta basada en aplicaciones telemáticas intuitivas y fáciles de manejar, lo que nos abre infinidad de nuevas vías para la implementación de las tecnologías en las aulas. Ha surgido un nuevo modelo de aprendizaje, el Aprendizaje 2.0. con características extrapoladas de la filosofía predominante en la web 2.0. Para dar respuesta a algunas de las necesidades surgidas bajo este nuevo paradigma tecnológico se están adaptando herramientas tradicionales y diseñando otras nuevas como puede ser la aplicación Open Conference Systems con la pretensión de facilitar la gestión y difusión de trabajos académicos contribuyendo positivamente en la formación de dichos estudiantes y del propio profesorado. Los orígenes de esta aplicación lo encontramos en el Public Knowledge Project (PKP, creado dentro de una iniciativa de investigación y desarrollo dirigida a mejorar la calidad académica y pública de la investigación científica a través del fomento y la innovación en la edición electrónica y de entornos de intercambio de conocimiento.

  11. Relación entre la lecto-escritura, el desempeño académico y la deserción estudiantil

    Directory of Open Access Journals (Sweden)

    Olga Lucía Uribe-Enciso

    2014-01-01

    Full Text Available El objetivo del presente estudio es determinar si existe relación entre la competencia lecto-escritora de los estudiantes de primer año en una universidad privada de Bucaramanga, su desempeño académico y su permanencia durante el primer año de estudio. Se tomó una población de 350 estudiantes que ingresaron en el segundo semestre del año 2011 para participar en la investigación. Se emplearon cuestionarios y entrevistas para indagar la opinión de los estudiantes y docentes acerca de las habilidades lectoescritoras y su relación con la vida académica. Adicionalmente, se consultaron bases de datos institucionales, los puntajes de la prueba nacional SABER 11 y el puntaje obtenido en la prueba institucional de ingreso que evaluó la producción escrita de un texto argumentativo. Los resultados muestran una relación entre la competencia lecto-escritora, el desempeño académico y la tasa de deserción estudiantil, hallazgo corroborado por la mayoría de los docentes entrevistados. Sin embargo, los estudiantes desertores declaran que dicha competencia no es fundamental en el éxito académico. El estudio demuestra la necesidad de implementar acciones de acompañamiento a la población estudiantil universitaria para prevenir la deserción temprana por factores asociados al bajo rendimiento académico causado por un bajo nivel de desarrollo en la competencia lecto-escritora.

  12. Lack of influence of GTP cyclohydrolase gene (GCH1 variations on pain sensitivity in humans

    Directory of Open Access Journals (Sweden)

    Dionne Raymond A

    2007-03-01

    Full Text Available Abstract Objectives To assess the effect of variations in GTP cyclohydrolase gene (GCH1 on pain sensitivity in humans. Methods Thermal and cold pain sensitivity were evaluated in a cohort of 735 healthy volunteers. Among this cohort, the clinical pain responses of 221 subjects after the surgical removal of impacted third molars were evaluated. Genotyping was done for 38 single nucleotide polymorphisms (SNPs whose heterozygosity > 0.2 in GCH1. Influence of the genetic variations including SNPs and haplotypes on pain sensitivity were analyzed. Results Minor allele frequencies and linkage disequilibrium show significant differences in European Americans, African Americans, Hispanic Americans and Asian Americans. Association analyses in European Americans do not replicate the previously reported important influence of GCH1 variations on pain sensitivity. Conclusion Considering population stratification, previously reported associations between GCH1 genetic variations and pain sensitivity appear weak or negligible in this well characterized model of pain.

  13. The Genetic Variation of Bali Cattle (Bos javanicus Based on Sex Related Y Chromosome Gene

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    A Winaya

    2011-09-01

    Full Text Available Bali cattle is very popular Indonesian local beef related to their status in community living process of farmers in Indonesia, especially as providers of meat and exotic animal. Bali cattle were able to adapt the limited environment and becoming local livestock that existed until recently.  In our early study by microsatellites showed that Bali cattle have specific allele. In this study we analyzed the variance of partly sex related Y (SRY gene sequence in Bali cattle bull as a source of cement for Artificial Insemination (AI.  Blood from 17 two location of AI center, Singosari, Malang and Baturiti, Bali was collected and then extracted to get the DNA genome.  PCR reaction was done to amplify partially of SRY gene segment and followed by sequencing PCR products to get the DNA sequence of SRY gene. The SRY gene sequence was used to determine the genetic variation and phylogenetic relationship.  We found that Bali cattle bull from Singosari has relatively closed genetic relationship with Baturiti. It is also supported that in early data some Bali bulls of Singosari were came from Baturiti. It has been known that Baturiti is the one source of Bali cattle bull with promising genetic potential. While, in general that Bali bull where came from two areas were not different on reproductive performances. It is important to understand about the genetic variation of Bali cattle in molecular level related to conservation effort and maintaining the genetic characters of the local cattle. So, it will not become extinct or even decreased the genetic quality of Indonesian indigenous cattle.   Key Words : Bali cattle, SRY gene, artificial insemination, phylogenetic, allele   Animal Production 13(3:150-155 (2011

  14. Transposable elements generate population-specific insertional patterns and allelic variation in genes of wild emmer wheat (Triticum turgidum ssp. dicoccoides).

    Science.gov (United States)

    Domb, Katherine; Keidar, Danielle; Yaakov, Beery; Khasdan, Vadim; Kashkush, Khalil

    2017-10-27

    Natural populations of the tetraploid wild emmer wheat (genome AABB) were previously shown to demonstrate eco-geographically structured genetic and epigenetic diversity. Transposable elements (TEs) might make up a significant part of the genetic and epigenetic variation between individuals and populations because they comprise over 80% of the wild emmer wheat genome. In this study, we performed detailed analyses to assess the dynamics of transposable elements in 50 accessions of wild emmer wheat collected from 5 geographically isolated sites. The analyses included: the copy number variation of TEs among accessions in the five populations, population-unique insertional patterns, and the impact of population-unique/specific TE insertions on structure and expression of genes. We assessed the copy numbers of 12 TE families using real-time quantitative PCR, and found significant copy number variation (CNV) in the 50 wild emmer wheat accessions, in a population-specific manner. In some cases, the CNV difference reached up to 6-fold. However, the CNV was TE-specific, namely some TE families showed higher copy numbers in one or more populations, and other TE families showed lower copy numbers in the same population(s). Furthermore, we assessed the insertional patterns of 6 TE families using transposon display (TD), and observed significant population-specific insertional patterns. The polymorphism levels of TE-insertional patterns reached 92% among all wild emmer wheat accessions, in some cases. In addition, we observed population-specific/unique TE insertions, some of which were located within or close to protein-coding genes, creating allelic variations in a population-specific manner. We also showed that those genes are differentially expressed in wild emmer wheat. For the first time, this study shows that TEs proliferate in wild emmer wheat in a population-specific manner, creating new alleles of genes, which contribute to the divergent evolution of homeologous genes

  15. Rasgos Complejos y Rendimiento Académico: Contribución de los Rasgos de Personalidad, Creencias de Autoeficacia e Intereses

    Directory of Open Access Journals (Sweden)

    MARCOS CUPANI

    2014-01-01

    Full Text Available El objetivo de este trabajo consistió en explorar la contribución de las facetas de personalidad, creencias de autoeficacia e intereses que carac - terizan a los estudiantes adolescentes con alto y bajo rendimiento académico en diferentes áreas del conocimiento. Mediante la implementación de un análisis discriminante, los resultados de este estudio indican que las tres medidas con - sideradas contribuyen de manera significativa a explicar, según el dominio, entre un 23% y un 50% del rendimiento académico. Se espera que la información aportada ayude a investigadores y profesionales del ámbito educativo a compren - der cuál es el patrón psicológico que facilita el éxito académico.

  16. Formación académica, valores, empatía y comportamientos socialmente responsables en estudiantes universitarios

    OpenAIRE

    Arango Tobón, Olber E.; Clavijo Zapata, Sandra J.; Puerta Lopera, Isabel C.; Sánchez Duque, José W.

    2014-01-01

    El objetivo de la presente investigación fue determinar la relación entre la formación académica, la empatía, los valores y comportamientos socialmente responsables de estudiantes de primero, quinto y décimo semestres de varios programas académicos de la Fundación Universitaria Luis Amigó. Se empleó un enfoque empírico-analítico, de diseño no experimental, tipo descriptivo y correlacional. Los instrumentos con los que se recolectó la información fueron el Cuestionario de Auto-atribución de Co...

  17. Educación para la sostenibilidad: la formación académica de arquitectos y urbanistas

    OpenAIRE

    Rosa María Chacón

    2012-01-01

    El propósito de este trabajo es analizar las relaciones entre sostenibilidad y educación superior en lo referente a la formación académica de arquitectos y urbanistas. La metodología utilizada se basa en el análisis teórico del desarrollo urbano sostenible, los eventos internacionales en el marco del decenio de la educación para la sostenibilidad y su relación con la educación superior y con las competencias esperables en la formación académica de arquitectos y urbanistas. Se concluye con una...

  18. Educación para la sostenibilidad: La formación académica de arquitectos y urbanistas

    OpenAIRE

    Chacón, Rosa María; Pampinella, Beatriz Graciela

    2012-01-01

    El propósito de este trabajo es analizar las relaciones entre sostenibilidad y educación superior en lo referente a la formación académica de arquitectos y urbanistas. La metodología utilizada se basa en el análisis teórico del desarrollo urbano sostenible, los eventos internacionales en el marco del decenio de la educación para la sostenibilidad y su relación con la educación superior y con las competencias esperables en la formación académica de arquitectos y urbanistas. Se concluy...

  19. Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

    DEFF Research Database (Denmark)

    Roumans, Nadia J T; Vink, Roel G; Gielen, Marij

    2015-01-01

    The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of the European DiOGenes study. Overweight and obese subjects (n = 469, 310 females, 159 m.......40-5.63). Concluding, variants of ECM genes are associated with weight regain after weight loss in a sex-specific manner....

  20. Common Variation in the DOPA Decarboxylase (DDC) Gene and Human Striatal DDC Activity In Vivo.

    Science.gov (United States)

    Eisenberg, Daniel P; Kohn, Philip D; Hegarty, Catherine E; Ianni, Angela M; Kolachana, Bhaskar; Gregory, Michael D; Masdeu, Joseph C; Berman, Karen F

    2016-08-01

    The synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on DOPA decarboxylase (DDC, AADC), an enzyme that is required for normative neural operations. Because rare, loss-of-function mutations in the DDC gene result in severe enzymatic deficiency and devastating autonomic, motor, and cognitive impairment, DDC common genetic polymorphisms have been proposed as a source of more moderate, but clinically important, alterations in DDC function that may contribute to risk, course, or treatment response in complex, heritable neuropsychiatric illnesses. However, a direct link between common genetic variation in DDC and DDC activity in the living human brain has never been established. We therefore tested for this association by conducting extensive genotyping across the DDC gene in a large cohort of 120 healthy individuals, for whom DDC activity was then quantified with [(18)F]-FDOPA positron emission tomography (PET). The specific uptake constant, Ki, a measure of DDC activity, was estimated for striatal regions of interest and found to be predicted by one of five tested haplotypes, particularly in the ventral striatum. These data provide evidence for cis-acting, functional common polymorphisms in the DDC gene and support future work to determine whether such variation might meaningfully contribute to DDC-mediated neural processes relevant to neuropsychiatric illness and treatment.

  1. Comunidades virtuales para promover la innovación académica universitaria: UNA realidad

    Directory of Open Access Journals (Sweden)

    Mayela Coto Chotto

    2016-03-01

    Full Text Available Los nuevos avances en las tecnologías para la información y comunicación (TIC y los enfoques pedagógicos modernos crean nuevas oportunidades para diseñar ambientes innovadores de aprendizaje. Sin embargo, a pesar de los esfuerzos significativos que se realizan en las universidades para cambiar la naturaleza del aprendizaje, el modelo tradicional de educación es todavía ampliamente utilizado, y constituye una de las principales razones la inadecuada preparación de los académicos para enfrentar estos nuevos retos. Este artículo muestra los resultados preliminares de una iniciativa que se desarrolló en la Universidad Nacional de Costa Rica (UNA mediante el proyecto “Comunidad de Práctica Virtual para la Innovación Académica en las Sedes Regionales de la Universidad Nacional”, el cual pretende promover un cambio cualitativo en la práctica docente de los académicos de las sedes regionales con el desarrollo y la aplicación de estrategias pedagógicas innovadoras y las TIC, creando a la vez condiciones para lograr un mayor grado de comunicación y compañerismo entre los docentes de las sedes regionales. El proyecto buscaba explorar un cambio en el enfoque de desarrollo profesional, de una formación tradicional a un aprendizaje en la práctica, utilizando para esto las estructuras conceptuales de las comunidades de práctica.

  2. Sobre a Produção Acadêmica Reichiana Relacionada à Área Educacional

    Directory of Open Access Journals (Sweden)

    Sara Quenzer Matthiesen

    Full Text Available Resumo A produção acadêmica em Universidades brasileiras que vincula Wilhelm Reich a diferentes áreas, produzindo novos conhecimentos em torno e a partir de suas ideias, tem crescido nos últimos anos, demonstrando que, para além da prática clínica, é possível identificarmos outras possibilidades de conhecimento de suas ideias articulando-as à Educação. Objetivando identificar as dissertações de mestrado e teses de doutorado que têm explorado suas ideias articulando-as à área educacional, essa pesquisa teórico-bibliográfica constatou que, dentre uma centena de produções acadêmicas produzidas entre 1979 e 2012 sobre o tema, 39 estão relacionadas à área educacional, sendo 29 dissertações de mestrado e 10 teses de doutorado. Analisados pelas categorias: “Ideias reichianas para a educação”, “Ideias reichianas e a educação de educadores”, “Ideias reichianas no cotidiano escolar”, “Ideias reichianas e a educação sexual” e “Aplicação das ideias reichianas em diferentes áreas da Educação”, os resultados desta pesquisa revelaram que este autor é um dos referenciais utilizados para se pensar temas educacionais contemporâneos no campo acadêmico brasileiro, demonstrando o quanto suas ideias podem contribuir para a formação e atuação de educadores.

  3. Violencia Escolar y Rendimiento Académico (VERA: aplicación de realidad aumentada

    Directory of Open Access Journals (Sweden)

    Mª del Carmen Pérez-Fuentes

    2011-08-01

    Full Text Available En la actualidad, dos son los problemas que de forma más notable comprometen el clima escolar en los Centros de Educación Secundaria: la violencia entre alumnos y el bajo rendimiento académico. Ambos aspectos, son tratados en múltiples trabajos de investigación, de donde se extraen datos que apoyan la existencia de una relación, cuanto menos compleja, entre la violencia escolar y el rendimiento académico. De la necesidad de crear nuevas herramientas para evaluar la convivencia escolar y su relación con el rendimiento académico; surge el desarrollo del recurso que presentamos: VERA-Nivel I. Se trata de un videojuego de realidad aumentada, que nos permite recabar información detallada sobre las formas de interacción que tienen los alumnos y con quién, y también, acerca de las habilidades cognitivas que poseen. Además, una de las ventajas que ofrece el uso de realidad aumentada es la posibilidad de analizar las interacciones de los alumnos con sus propios compañeros, en el contexto real del aula. De forma paralela, la aplicación nos permite recompensar conductas no violentas. La aplicación VERA-Nivel I no solo se limita al ámbito educativo, sino que puede y debe ser generalizada a otros contextos en los que proceda el mismo objeto de evaluación.

  4. currículo académico

    Directory of Open Access Journals (Sweden)

    Róger Martínez Castillo

    2006-01-01

    Full Text Available El sistema de desarrollo socio-económico dominante, con sus políticas neoliberales y enfoques mercado-céntricos contribuyen a agravar los problemas socio-ambientales. No hay conciencia política de que el propio modelo de desarrollo vigente es el que genera la degradación socio-ambiental. Este tipo de temas no ha sido fácilmente comprendido o aceptado en el ámbito educativo formal, debido a la resistencia de la educación oficial para integrarlos en sus marcos académicos. Ante la crisis socio-económica y ambiental que vive nuestra sociedad, la educación ambiental representa una opción viable a la problemática general, para promover cambios sociales, nuevos conocimientos, permitir la participación ciudadana y un desarrollo sustentable, que estimulen una sociedad más justa, democrática y solidaria.

  5. Riesgo familiar total en familias con escolares según rendimiento académico Risco familiar total em famílias com escolares conforme aproveitamento acadêmico Total family risk in families with schoolchildren according to academic performance

    Directory of Open Access Journals (Sweden)

    CAROLINA LUCERO ENRÍQUEZ GUERRERO

    Full Text Available Este artículo presenta los resultados del estudio cuyo objetivo fue establecer las diferencias en el riesgo familiar entre dos grupos de familias: con niños escolares de alto rendimiento y niños de bajo rendimiento académico en un centro educativo distrital de Bogotá. Metodología: estudio descriptivo comparativo transversal con un componente analítico y abordaje cuantitativo; la muestra fue de 186 familias, durante abril a julio de 2007. Los resultados muestran predominio de familias nucleares en ambos grupos (65%, relación inversa entre el riesgo familiar total evaluado por el instrumento RFT 7-70 y el rendimiento académico del escolar de la familia, es decir que las familias que registraron riesgo alto (9% y medio (31% en mayor proporción son familias con escolares de bajo rendimiento académico, frente al predominio del riesgo familiar bajo (78% en las familias con niños de alto rendimiento. Se aplicó t de student para diferencia de medias y se encontró asociación (P = 0,02 entre el riesgo familiar total alto y el bajo rendimiento académico del escolar. En conclusión, estos resultados sugieren principalmente que se deben priorizar los factores de riesgo que determinan mayor riesgo familiar en familias con escolares de bajo rendimiento académico y dar atención de salud integral con enfoque familiar e intersectorial, y participación activa de la comunidad. Continuar investigando en posibles asociaciones entre salud individual, prácticas de salud, educación, ambiente socioeconómico y psicoafectivo de la familia y el logro educativo de escolares en familias con niños en edad escolar.Este artigo apresenta os resultados de um levantamento que objetiva estabelecer as diferenças no risco familiar entre dois grupos de famílias: com crianças escolares de alto aproveitamento acadêmico e crianças escolares de baixo aproveitamento acadêmico em um centro educativo distrital de Bogotá. Metodologia: levantamento descritivo

  6. Riesgo familiar total en familias con escolares según rendimiento académico Total family risk in families with schoolchildren according to academic performance Risco familiar total em famílias com escolares conforme aproveitamento acadêmico

    Directory of Open Access Journals (Sweden)

    CATAÑO ORDÓÑEZ NHORA

    2009-12-01

    Full Text Available Este artículo presenta los resultados del estudio cuyo objetivo fue establecer las diferencias en el riesgo familiar entre dos grupos de familias: con niños escolares de alto rendimiento y niños de bajo rendimiento académico en un centro educativo distrital de Bogotá. Metodología: estudio descriptivo comparativo transversal con un componente analítico y abordaje cuantitativo; la muestra fue de 186 familias, durante abril a julio de 2007. Los resultados muestran predominio de familias nucleares en ambos grupos (65%, relación inversa entre el riesgo familiar total evaluado por el instrumento RFT 7-70 y el rendimiento académico del escolar de la familia, es decir que las familias que registraron riesgo alto (9% y medio (31% en mayor proporción son familias con escolares de bajo rendimiento académico, frente al predominio del riesgo familiar bajo (78% en las familias con niños de alto rendimiento. Se aplicó t de student para diferencia de medias y se encontró asociación (P = 0,02 entre el riesgo familiar total alto y el bajo rendimiento académico del escolar. En conclusión, estos resultados sugieren principalmente que se deben priorizar los factores de riesgo que determinan mayor riesgo familiar en familias con escolares de bajo rendimiento académico y dar atención de salud integral con enfoque familiar e intersectorial, y participación activa de la comunidad. Continuar investigando en posibles asociaciones entre salud individual, prácticas de salud, educación, ambiente socioeconómico y psicoafectivo de la familia y el logro educativo de escolares en familias con niños en edad escolar.This article presents the results of a study whose objective was to establish the family risk differences among two groups of families: one with schoolchildren that show high academic performance and children that show low academic performance in an educational center in Bogotá. Methodology: cross-sectional comparative study with and

  7. La biblioteca académica 2.0: Innovación en México

    Directory of Open Access Journals (Sweden)

    Lizbeth Berenice Herrera Delgado

    2011-01-01

    Full Text Available La Biblioteca 2.0 (B2 ha sido objeto de atención y difusión, de una discusión entre los medios electrónicos, cobijada por el marco informal de los bloggers bibliotecarios o “bibliobloggers2”. En el presente trabajo se cavila sobre la B2 y su innovación desde el entorno académico y su contexto en México. Ejercicio que pone de manifiesto por un lado el rol que juega en las tecnologías de la información y la comunicación (TIC, mientas que por el otro lado se cuestiona su papel al interior de las Unidades de Información. Conjugando entonces las propuestas que componen a la B2, estudiando los tipos de innovación que existen y vertiendo finalmente una opinión acorde al contexto mexicano es que surge así la concepción de las bibliotecas académicas mexicanas 2.0.

  8. La biblioteca académica 2.0: Innovación en México

    Directory of Open Access Journals (Sweden)

    Lizbeth Berenice Herrera Delgado

    2011-07-01

    Full Text Available La Biblioteca 2.0 (B2 ha sido objeto de atención y difusión, de una discusión entre los medios electrónicos, cobijada por el marco informal de los bloggers bibliotecarios o “bibliobloggers1”. En el presente trabajo se cavila sobre la B2 y su innovación desde el entorno académico y su contexto en México. Ejercicio que pone de manifiesto por un lado el rol que juega en las tecnologías de la información y la comunicación (TIC, mientas que por el otro lado se cuestiona su papel al interior de las Unidades de Información. Conjugando entonces las propuestas que componen a la B2, estudiando los tipos de innovación que existen y vertiendo finalmente una opinión acorde al contexto mexicano es que surge así la concepción de las bibliotecas académicas mexicanas 2.0.

  9. Estratégias de aprendizagem e desempenho acadêmico: evidências de validade

    Directory of Open Access Journals (Sweden)

    Katya Luciane de Oliveira

    Full Text Available O objetivo deste estudo foi verificar a validade fatorial de uma escala de estratégias de aprendizagem, bem como explorar sua validade concorrente em relação ao desempenho acadêmico de estudantes. Participaram 815 crianças do Ensino Fundamental de escolas públicas e privadas dos Estados de São Paulo e Minas Gerais. A Escala de Estratégias de Aprendizagem foi aplicada coletivamente. Para a operacionalização dos objetivos, recorreu-se à análise fatorial exploratória. Os alphas de Cronbach do instrumento e das três subescalas revelaram índices aceitáveis de consistência interna. A análise de variância apontou diferenças estatisticamente significativas entre o desempenho acadêmico e a pontuação na escala. Os dados foram discutidos em termos de suas possíveis implicações para a área de avaliação psicoeducacional.

  10. No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes.

    Science.gov (United States)

    Soerensen, Mette; Nygaard, Marianne; Debrabant, Birgit; Mengel-From, Jonas; Dato, Serena; Thinggaard, Mikael; Christensen, Kaare; Christiansen, Lene

    2016-06-01

    In this study we explored the association between aging-related phenotypes previously reported to predict survival in old age and variation in 77 genes from the DNA repair pathway, 32 genes from the growth hormone 1/ insulin-like growth factor 1/insulin (GH/IGF-1/INS) signalling pathway and 16 additional genes repeatedly considered as candidates for human longevity: APOE, APOA4, APOC3, ACE, CETP, HFE, IL6, IL6R, MTHFR, TGFB1, SIRTs 1, 3, 6; and HSPAs 1A, 1L, 14. Altogether, 1,049 single nucleotide polymorphisms (SNPs) were genotyped in 1,088 oldest-old (age 92-93 years) Danes and analysed with phenotype data on physical functioning (hand grip strength), cognitive functioning (mini mental state examination and a cognitive composite score), activity of daily living and self-rated health. Five SNPs showed association to one of the phenotypes; however, none of these SNPs were associated with a change in the relevant phenotype over time (7 years of follow-up) and none of the SNPs could be confirmed in a replication sample of 1,281 oldest-old Danes (age 94-100). Hence, our study does not support association between common variation in the investigated longevity candidate genes and aging-related phenotypes consistently shown to predict survival. It is possible that larger sample sizes are needed to robustly reveal associations with small effect sizes. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Evaluación a Académicos Universitarios en Francia. Interpretación de Distancias con un Caso Mexicano Evaluación a Académicos Universitarios en Francia. Interpretación de Distancias con un Caso Mexicano

    Directory of Open Access Journals (Sweden)

    Rosalía S. Lastra B.

    2012-02-01

    Full Text Available Una controvertida temática universitaria es la forma en que el sector público promueve el reconocimiento de los académicos a través de programas de pago al mérito, consistentes en verificar la “productividad académica”. En la búsqueda de experiencias en países con sistemas educativos connotados, se emprendió la exploración del caso francés. Aunque en éste no se practican dichos programas, los elementos encontrados sobre clasificación de académicos permiten reflexionar sobre los distintos retos de una comunidad consolidada y los de otra en consolidación, dados sus respectivos fundamentos contextuales, estructuralesy actitudinales. Su convergencia está en la búsqueda de “excelencia” y en la preocupación por determinar bajo qué circunstancias y con qué decisiones se logran mejores resultados. Después de las generalidades del sistema francés, se presentan reflexiones sobre distanciasencontradas con un grupo mexicano al percibir la evaluación para ingreso de nuevos académicos, pertinencia del académico multifuncional y tipo de estímulos, finalizando conconsideraciones institucionales.A controversial university issue is the way that the public sector promotes the recognition of some of the prominent efforts of academia, through programs of merit pay, consistent in the verification of “academic productivity”. In search of the experience in countries with renowned educational systems, the exploration of a French case was undertaken. Although in France these programs are not in operation, the elements found regarding the academic classification system may allow for established deliberations on the different challenges faced by a consolidated academic community and those of another in the process of consolidation, considering their respective contextual, structural and attitudinal fundamentals. Their convergence is focused on the search for “excellence” and in that concern to determine under what circumstances and

  12. Sequence variation in mitochondrial cox1 and nad1 genes of ascaridoid nematodes in cats and dogs from Iran.

    Science.gov (United States)

    Mikaeili, F; Mirhendi, H; Mohebali, M; Hosseini, M; Sharbatkhori, M; Zarei, Z; Kia, E B

    2015-07-01

    The study was conducted to determine the sequence variation in two mitochondrial genes, namely cytochrome c oxidase 1 (pcox1) and NADH dehydrogenase 1 (pnad1) within and among isolates of Toxocara cati, Toxocara canis and Toxascaris leonina. Genomic DNA was extracted from 32 isolates of T. cati, 9 isolates of T. canis and 19 isolates of T. leonina collected from cats and dogs in different geographical areas of Iran. Mitochondrial genes were amplified by polymerase chain reaction (PCR) and sequenced. Sequence data were aligned using the BioEdit software and compared with published sequences in GenBank. Phylogenetic analysis was performed using Bayesian inference and maximum likelihood methods. Based on pairwise comparison, intra-species genetic diversity within Iranian isolates of T. cati, T. canis and T. leonina amounted to 0-2.3%, 0-1.3% and 0-1.0% for pcox1 and 0-2.0%, 0-1.7% and 0-2.6% for pnad1, respectively. Inter-species sequence variation among the three ascaridoid nematodes was significantly higher, being 9.5-16.6% for pcox1 and 11.9-26.7% for pnad1. Sequence and phylogenetic analysis of the pcox1 and pnad1 genes indicated that there is significant genetic diversity within and among isolates of T. cati, T. canis and T. leonina from different areas of Iran, and these genes can be used for studying genetic variation of ascaridoid nematodes.

  13. Autoeficacia y procrastinación académica en estudiantes de una universidad nacional de Lima Metropolitana, 2017

    OpenAIRE

    Chigne Moscoso, Carlos Omar

    2017-01-01

    La presente investigación surgió ante el planteamiento de la problemática general: ¿Cómo se relaciona la autoeficacia con la procrastinación académica en estudiantes de la escuela de radio imagen de una Universidad Nacional de Lima Metropolitana? El objetivo del presente estudio fue establecer la relación entre la autoeficacia y la procrastinación académica en dichos estudiantes. La investigación es de tipo aplicada, no experimental y correlacional. La muestra fue no probabi...

  14. Análisis de la Productividad Académica de Profesores del Área de Ingeniería

    OpenAIRE

    Acevedo, Diofanor; Montero, Piedad M; Duran, Marlene

    2016-01-01

    El objetivo de este trabajo fue analizar la productividad académica y la percepción de calidad en la enseñanza de los profesores de planta de cuatro áreas de ingeniería de una Institución Universitaria en Colombia. La productividad académica en Colombia, se refiere a las publicaciones de artículos científicos, ponencias, premios, patentes, producciones técnicas y dirección de tesis de postgrado. Se analizaron documentos institucionales y se aplicaron dos cuestionarios, uno a profesores y otro...

  15. Factores que inciden en el rendimiento académico de los estudiantes de Ingeniería Industrial, 2017

    OpenAIRE

    Sánchez Ramírez, Luz Graciela

    2017-01-01

    La tesis doctoral titulada “Factores que inciden en el rendimiento académico de los estudiantes de Ingeniería Industrial”. Expone una aproximación teórica a los conceptos asociados al rendimiento, por lo que se centralizó en determinar la relación que existe entre los factores que se relacionan con el rendimiento académico de los estudiantes. Se analiza la temática de la educación superior desde diferentes ramas del conocimiento, que de una u otra forma, han provocado el proces...

  16. Redes académicas al interior de las escuelas chilenas: Un estudio exploratorio utilizando Modelos Exponenciales de Grafos Aleatorios (ERGM

    Directory of Open Access Journals (Sweden)

    Diego Palacios

    2016-12-01

    Full Text Available El artículo analiza las redes académicas que se producen al interior de aulas chilenas entre estudiantes de Tercer Año Medio (K-11 en distintos tipos de establecimientos, a través de Modelos Exponenciales de Grafos Aleatorios (ERGM. A partir de un modelo analítico que incorpora variables endógenas (reciprocidad, conectividad simple, popularidad, actividad, triangulación y variables exógenas (género del estudiante, nivel socioeconómico, capital cultural, capital social, se observa que el efecto más importante para explicar las redes académicas se produce por variables endógenas (especialmente por la reciprocidad y triangulación por sobre el componente exógeno, lo que podría indicar que las relaciones microsociales académicas se configuran, a lo menos en parte, independientemente de las características de los estudiantes. Asimismo, los resultados indican la existencia de relaciones complejas al interior del aula, y algunas diferencias interesantes entre los cursos respecto del efecto de las variables sociales y culturales, lo que podría indicar que algunos patrones de distinción social son relevantes en las interacciones académicas al interior del aula

  17. Inteligencia emocional y rendimiento académico en estudiantes universitarios de Farmacia y Bioquímica en Huancayo

    Directory of Open Access Journals (Sweden)

    Iris Carrasco Díaz

    2013-06-01

    Full Text Available Objetivos: Determinar el grado de relación entre la inteligencia emocional y el rendimiento académico de los estudiantes de la carrera profesional de Farmacia y Bioquímica de la Universidad Peruana “Los Andes”. Métodos: Es un estudio con diseño descriptivo correlacional, para ello han participado 150 estudiantes del 1° al 9° ciclo a quienes se les aplicaron el Inventario Emocional de BarOn, Inventario de Coeficiente Emocional (I-CE que permitió conocer su inteligencia emocional, asimismo se recopilaron los promedios ponderados al final del semestre 2012-II de cada estudiante para medir el rendimiento académico. Resultados: Los estudiantes que presentaron una inteligencia emocional promedio o adecuado fue (X2= 183,33 y p= 0,00 81 (54%; los que presentaron una capacidad emocional bajo son 45 (30%; en cuanto a los componentes; intrapersonal presentaron una capacidad emocional adecuada o promedio es 95 (63%, siendo la más alta en relación a los demás componentes; seguido de adaptabilidad 89 (59%, manejo de estrés 86 (57%; interpersonal 76 (51% y estado de ánimo 74 (49% quienes presentaron una inteligencia emocional promedio o adecuado; los estudiantes que alcanzaron una baja capacidad emocional fueron en los siguientes componentes: adaptabilidad 56 (37%; interpersonal 41 (27%; intrapersonal 36 (24%; estado de ánimo 40 (27% y 32 (22% en manejo de estrés. El rendimiento académico promedio semestral es de 12,34 categorizado como regular para 98 (65% de estudiantes. Conclusiones: Se determinó que existe una correlación significativa entre la inteligencia emocional con el rendimiento académico, (r=0,403 (p≤0,01. En relación a los componentes intrapersonal, interpersonal, adaptabilidad manejo de estrés y estados de ánimo presentan también una correlación significativa (p≤0,01 con el rendimiento académico.

  18. Implicación académica en matemáticas: percepcion de metas docentes y processos autorregularorios en estudiantes de bachillerato

    Directory of Open Access Journals (Sweden)

    Martha Leticia Gaeta González

    2015-04-01

    Full Text Available Profundizar en el estudio de los procesos personales y contextuales que inciden en la implicación académica de los estudiantes se considera necesario, ante el bajo rendimiento en muchos contextos académicos, principalmente en el área de matemáticas. En este estudio se analizaron los procesos de autorregulación del aprendizaje y la percepción de metas docentes en relación con el enfoque de aprendizaje y el rendimiento académico en matemáticas, en estudiantes de bachillerato. Participaron 231 estudiantes, entre 16 y 18 años de edad. El plan metodológico incluyó un análisis de regresión de los datos obtenidos mediante tres instrumentos: el Inventario de Procesos de Autorregulación del Aprendizaje, el Cuestionario de Percepción de Metas Docentes y el Inventario de Procesos de Estudio. Se encontró que la autorregulación del aprendizaje incide positivamente en el rendimiento académico de los estudiantes, la percepción de las metas docentes contribuye indirectamente y el enfoque de aprendizaje media este proceso.

  19. Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed-dependent

    Science.gov (United States)

    Prion genotype in sheep confer resistance to scrapie. In cattle, lymphocyte profile has been found to be associated with prion genotype. Therefore, the aim of this study was to determine if variations in the sheep prion gene were associated with leukocyte populations as measured by complete blood ce...

  20. Prácticas de lectura y escritura académicas en la universidad colombiana (Scholarly Reading and Writing Practices at Colombian Universities (Pratiques académiques de lecture et d'écriture à l'Université colombienne (Práticas de leitura e escrita acadêmicas na universidade colombiana

    Directory of Open Access Journals (Sweden)

    Graciela Uribe-Álvarez

    2011-06-01

    Full Text Available ResumenEste artículo de revisión presenta el análisis de algunas prácticas de lectura y escritura académicas en la universidad colombiana, conocidas por diversos medios (bases de datos, memorias en páginas web y en cd-rom de congresos, coloquios, encuentros y seminarios. Pretende aportar a la reflexión y el diálogo académi- co entre profesionales de la educación, a partir de experiencias en campos problemáticos específicos. Los resultados se susten- tan en el análisis de 40 trabajos de investigación (algunos de ellos se reseñan en los que es posible identificar: 1 Temática, 2 Institución, 3 Población sujeto, 4 Situación problemática, 5 Reconocimiento de los marcos teóricos de referencia y explici- tación de la metodología, 6 Presentación de resultados. Esta revisión, enmarcada en la investigación interinstitucional finan- ciada por Colciencias ¿Para qué se lee y escribe en la universidad colombiana? Un aporte a la consolidación de la cultura académi- ca, busca exponer las problemáticas que, de manera particular, han reconocido los diferentes investigadores y sus grupos con el propósito de mostrar cómo esta investigación interinstitucional acoge inquietudes e interrogantes, en relación con los procesos lectores y escritores, en la educación superior.AbstractThis review paper presents the analysis of certain scholarly reading and writing practices at Colombian universities, as found in various databases and proceedings of congresses, colloquia, seminaries, and meetings that are available online or on CD-ROM. It aims to contribute to the academic dia- logue among educations professionals by putting forward experiences in specific fields. The results are based on the analysis of 40 research papers, some of which are summa- rized, that allowed identifications of: 1 Topic, 2 Institution, 3 Population subject, 4 Situation of the problem, 5 Rec- ognition of theoretical framework and methodology made explicit, 6

  1. Factores determinantes del rendimiento académico en el grado de Arquitectura Técnica de la Universidad de Alicante

    OpenAIRE

    Mora García, Raúl Tomás; Céspedes López, María Francisca; Pérez Sánchez, Juan Carlos; Pérez Sánchez, Vicente Raúl; García González, Encarnación

    2015-01-01

    El rendimiento académico de los estudiantes universitarios está influenciado por una gran diversidad de factores y es uno de los elementos que influye principalmente al abandono de las enseñanzas universitarias. Conocer los factores que pueden estar interviniendo en el rendimiento académico de los estudiantes puede resultar de vital importancia para mejorar el proceso de enseñanza-aprendizaje y la calidad universitaria. En esta investigación se pretende determinar los posibles factores que in...

  2. Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory.

    Science.gov (United States)

    Ross, Robert S; Medrano, Paolo; Boyle, Kaitlin; Smolen, Andrew; Curran, Tim; Nyhus, Erika

    2015-11-01

    Recognition memory is defined as the ability to recognize a previously encountered stimulus and has been associated with spatially and temporally distinct event-related potentials (ERPs). Allelic variations of the serotonin transporter gene (SLC6A4) have recently been shown to impact memory performance. Common variants of the serotonin transporter-linked polymorphic region (5HTTLPR) of the SLC6A4 gene result in long (l) and short (s) allelic variants with carriers of the s allele having lowered transcriptional efficiency. Thus, the current study examines the effects polymorphisms of the SLC6A4 gene have on performance and ERP amplitudes commonly associated with recognition memory. Electroencephalogram (EEG), genetic, and behavioral data were collected from sixty participants as they performed an item and source memory recognition task. In both tasks, participants studied and encoded 200 words, which were then mixed with 200 new words during retrieval. Participants were monitored with EEG during the retrieval portion of each memory task. EEG electrodes were grouped into four ROIs, left anterior superior, right anterior superior, left posterior superior, and right posterior superior. ERP mean amplitudes during hits in the item and source memory task were compared to correctly recognizing new items (correct rejections). Results show that s-carriers have decreased mean hit amplitudes in both the right anterior superior ROI 1000-1500ms post stimulus during the source memory task and the left anterior superior ROI 300-500ms post stimulus during the item memory task. These results suggest that individual differences due to genetic variation of the serotonin transporter gene influences recognition memory. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Allelic Variations at Four Major Maturity E Genes and Transcriptional Abundance of the E1 Gene Are Associated with Flowering Time and Maturity of Soybean Cultivars

    Science.gov (United States)

    Wang, Yueqiang; Chen, Xin; Ren, Haixiang; Yang, Jiayin; Cheng, Wen; Zong, Chunmei; Gu, Heping; Qiu, Hongmei; Wu, Hongyan; Zhang, Xingzheng; Cui, Tingting; Xia, Zhengjun

    2014-01-01

    The time to flowering and maturity are ecologically and agronomically important traits for soybean landrace and cultivar adaptation. As a typical short-day crop, long day conditions in the high-latitude regions require soybean cultivars with photoperiod insensitivity that can mature before frost. Although the molecular basis of four major E loci (E1 to E4) have been deciphered, it is not quite clear whether, or to what degree, genetic variation and the expression level of the four E genes are associated with the time to flowering and maturity of soybean cultivars. In this study, we genotyped 180 cultivars at E1 to E4 genes, meanwhile, the time to flowering and maturity of those cultivars were investigated at six geographic locations in China from 2011 to 2012 and further confirmed in 2013. The percentages of recessive alleles at E1, E2, E3 and E4 loci were 38.34%, 84.45%, 36.33%, and 7.20%, respectively. Statistical analysis showed that allelic variations at each of four loci had a significant effect on flowering time as well as maturity. We classified the 180 cultivars into eight genotypic groups based on allelic variations of the four major E loci. The genetic group of e1-nf representing dysfunctional alleles at the E1 locus flowered earliest in all the geographic locations. In contrast, cultivars in the E1E2E3E4 group originated from the southern areas flowered very late or did not flower before frost at high latitude locations. The transcriptional abundance of functional E1 gene was significantly associated with flowering time. However, the ranges of time to flowering and maturity were quite large within some genotypic groups, implying the presence of some other unknown genetic factors that are involved in control of flowering time or maturity. Known genes (e.g. E3 and E4) and other unknown factors may function, at least partially, through regulation of the expression of the E1 gene. PMID:24830458

  4. Using gene expression noise to understand gene regulation

    NARCIS (Netherlands)

    Munsky, B.; Neuert, G.; van Oudenaarden, A.

    2012-01-01

    Phenotypic variation is ubiquitous in biology and is often traceable to underlying genetic and environmental variation. However, even genetically identical cells in identical environments display variable phenotypes. Stochastic gene expression, or gene expression "noise," has been suggested as a

  5. Socialización del conocimiento académico con el uso de tecnologías de información y comunicación (TIC

    Directory of Open Access Journals (Sweden)

    Rixio Nava Muñoz

    2007-09-01

    Full Text Available Este estudio está orientado hacia el conocimiento de los enfoques y tendencias, que en la actualidad interpretan muchos autores con respecto a la socialización del conocimiento académico y su relación sistemática respecto al uso de la tecnología de la información y comunicación. En el desarrollo del estudio se utilizó una metodología de carácter descriptivo cuya modalidad esta contemplada como proyecto factible. Asimismo, se mencionan literalmente las teorías que soportan y fortalecen los avances en el uso de las tecnologías dentro de las instituciones universitarias como estrategias funcionales y operativas para el intercambio de información académica e institucional. Los resultados revelan que de acuerdo a las tendencias y enfoques interpuestos por los autores consultados, se determina el soporte de esta tecnología para la socialización del conocimiento académico, situación analizada en función de la alta producción académica y capital intelectual en las instituciones de educación superior que escasamente puede ser transferida de manera estandarizada con el fin de establecer un proceso de socialización del conocimiento académico efectivo. En conclusión, debe preverse la estandarización en la transferencia sistemática de información institucional, en pro de asumir un proceso interactivo y efectivo para el suministro del conocimiento académico de la sociedad en general.

  6. Intervención psicoeducativa para disminuir el estrés académico en estudiantes de primer año de Medicina

    Directory of Open Access Journals (Sweden)

    Yanet Díaz Martín

    2015-04-01

    Full Text Available Se realizó un estudio de intervención en estudiantes de primer año de la carrera Medicina, en el período de noviembre de 2012 a enero de 2013, con el objetivo de implementar una intervención psicoeducativa para disminuir el estrés académico en ellos. Se utilizó un muestreo intencional puro, donde se escogieron 19 estudiantes del año y carrera referidos, con edades comprendidas entre los 18 y 22 años de edad y que presentaban síntomas y conductas asociadas al padecimiento de estrés académico. Para la etapa diagnóstica y de evaluación final se utilizó el Inventario SISCO del Estrés Académico, al cual se le hizo una normalización sociocultural. Los estresores encontrados, los síntomas y las estrategias de afrontamientos desadaptadas mostraron la necesidad de diseñar y aplicar la intervención educativa. Los estudiantes presentaron antes de la intervención un predominio del nivel moderado de estrés académico, con dificultades con sus estrategias de afrontamiento. Posterior a la intervención realizada predominó el nivel leve y mejoraron las estrategias de afrontamiento enfocadas a la solución del problema, el manejo del estrés académico

  7. Autoeficacia en escolares adolescentes: su relación con la depresión, el rendimiento académico y las relaciones familiares

    Directory of Open Access Journals (Sweden)

    Iris X. Galicia-Moyeda

    2013-05-01

    Full Text Available Las relaciones familiares son estimadas como elementos mediadores en diferentes tipos de autoeficacia; no obstante existe poca evidencia sobre la mediación de las relaciones familiares con la autoeficacia académica. Con respecto a ésta última se ha reportado su relación con la ansiedad y poco se ha documentado el vínculo con la depresión. En este trabajo se explora la relación entre la depresión, la autoeficacia académica, la dinámica familiar y el rendimiento académico. Participaron ochenta alumnos de educación secundaria, divididos en dos grupos en función de sus puntajes del Inventario de Depresión de Kovacs: en uno de ellos se incluyeron los que fueron identificados como deprimidos severos y en el otro, los que se diagnosticaron sin depresión. A ambos grupos les fueron aplicadas dos escalas: Clima Social en la Familia y Autoeficacia. Los resultados revelan una relación inversa entre depresión y autoeficacia total. La cohesión familiar correlaciona positivamente con la autoeficacia total y con el factor de autoeficacia académica en los sujetos sin depresión, en tanto que en los sujetos deprimidos severos las relaciones familiares conflictivas correlacionan de manera negativa tanto en el factor de autoeficacia social como en la autoeficacia académica.

  8. Melanopsin gene variations interact with season to predict sleep onset and chronotype.

    Science.gov (United States)

    Roecklein, Kathryn A; Wong, Patricia M; Franzen, Peter L; Hasler, Brant P; Wood-Vasey, W Michael; Nimgaonkar, Vishwajit L; Miller, Megan A; Kepreos, Kyle M; Ferrell, Robert E; Manuck, Stephen B

    2012-10-01

    The human melanopsin gene has been reported to mediate risk for seasonal affective disorder (SAD), which is hypothesized to be caused by decreased photic input during winter when light levels fall below threshold, resulting in differences in circadian phase and/or sleep. However, it is unclear if melanopsin increases risk of SAD by causing differences in sleep or circadian phase, or if those differences are symptoms of the mood disorder. To determine if melanopsin sequence variations are associated with differences in sleep-wake behavior among those not suffering from a mood disorder, the authors tested associations between melanopsin gene polymorphisms and self-reported sleep timing (sleep onset and wake time) in a community sample (N = 234) of non-Hispanic Caucasian participants (age 30-54 yrs) with no history of psychological, neurological, or sleep disorders. The authors also tested the effect of melanopsin variations on differences in preferred sleep and activity timing (i.e., chronotype), which may reflect differences in circadian phase, sleep homeostasis, or both. Daylength on the day of assessment was measured and included in analyses. DNA samples were genotyped for melanopsin gene polymorphisms using fluorescence polarization. P10L genotype interacted with daylength to predict self-reported sleep onset (interaction p sleep onset among those with the TT genotype was later in the day when individuals were assessed on longer days and earlier in the day on shorter days, whereas individuals in the other genotype groups (i.e., CC and CT) did not show this interaction effect. P10L genotype also interacted in an analogous way with daylength to predict self-reported morningness (interaction p sleep onset and chronotype as a function of daylength, whereas other genotypes at P10L do not seem to have effects that vary by daylength. A better understanding of how melanopsin confers heightened responsivity to daylength may improve our understanding of a broad range of

  9. Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors.

    Science.gov (United States)

    Figueroa, Jonine D; Sakoda, Lori C; Graubard, Barry I; Chanock, Stephen; Rubertone, Mark V; Erickson, R Loren; McGlynn, Katherine A

    2008-11-01

    Testicular germ cell tumors (TGCT) that arise in young men are composed of two histologic types, seminomas and nonseminomas. Risk patterns for the two types appear to be similar and may be related to either endogenous or exogenous hormonal exposures in utero. Why similar risk patterns would result in different histologic types is unclear, but could be related to varying genetic susceptibility profiles. Genetic variation in hormone metabolizing genes could potentially modify hormonal exposures, and thereby affect which histologic type a man develops. To examine this hypothesis, 33 single nucleotide polymorphisms (SNPs) in four hormone metabolism candidate genes (CYP1A1, CYP17A1, HSD17B1, HSD17B4) and the androgen receptor gene (AR) were genotyped. Associations with TGCT were evaluated among 577 TGCT cases (254 seminoma, 323 nonseminoma) and 707 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) study. There were no significant associations with TGCT overall based on a test using an additive model. However, compared to homozygotes of the most common allele, two nonredundant SNPs in CYP1A1 were inversely associated with nonseminoma: CYP1A1 promoter SNP rs4886605 OR = 0.75 (95% CI = 0.54-1.04) among the heterozygotes and OR = 0.37, 95% CI = 0.12-1.11 among the homozygotes with a p-value for trend = 0.02; rs2606345 intron 1 SNP, OR = 0.69 (95% CI = 0.51-0.93) among heterozygotes and OR = 0.70 (95% CI = 0.42-1.17) among homozygotes, with a p-value for trend = 0.02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma.

  10. Hábitos saludables y rendimiento académico en escolares de 8 a 10 años

    OpenAIRE

    Peiró Giner, Sara

    2017-01-01

    En este trabajo se analizan hábitos saludables como horas de sueño, actividad física y ocio sedentario, en un grupo de 100 escolares de 3º y 4º de Educación Primaria, evaluando su asociación con el rendimiento académico. La información se obtuvo mediante un cuestionario para padres e hijos. Los datos revelan unos hábitos adecuados en relación a las horas de sueño y realización de actividad física extraescolar, que tienen efecto en los resultados académicos. No hay un consumo excesivo de telev...

  11. Estrés académico en estudiantes de la Facultad de Farmacia y Bioanálisis, Universidad de los Andes, Mérida-Venezuela

    OpenAIRE

    Labrador Chacón, Carmen Zulay

    2012-01-01

    En esta tesis se ha tenido como objetivo, estudiar el estrés académico, así como algunos recursos psicosociales empleados, para su afrontamiento, en estudiantes de la Universidad de Los Andes, Mérida-Venezuela. La muestra estuvo constituida por 856 estudiantes del curso regular, de la Facultad de Farmacia y Bioanálisis. Para la medición del nivel de estrés académico se empleó el Cuestionario de Evaluación del Estrés Académico (CEEA) (Joan De Pablo, 2002). Para medir las variables sociodemográ...

  12. El componente de la internacionalización en el Régimen Académico de la Universidad de Costa Rica

    Directory of Open Access Journals (Sweden)

    Muñoz Guillén, Mercedes

    2012-02-01

    Full Text Available Resumen: En el presente artículo se analizó la internacionalización y sus diversas formas de movilidad académica e impacto en el Régimen Académico (RA de la Universidad de Costa Rica (UCR. Este componente tiene como eje la formación de cuadros docentes a nivel de posgrado en universidades extranjeras, y su manifestación en las 1676 profesoras y profesores que conforman el citado Régimen. Se elaboró una base de datos fundamentada en la compilación de los registros referentes al profesorado en RA de la UCR al 31 de mayo del 2011. Se determinó que 1290 docentes poseen posgrados; de estos el 27% tienen doctorado, el 42% maestrías y un 8% especialidades. El 52% de los posgrados fueron obtenidos en universidades del exterior y el 65% realizaron estudios al amparo del Programa de Becas al Exterior de la Institución. Se observaron números similares y más altos de graduados en instituciones de Norteamérica y Europa; números menores en América Latina y en los países de Asia/Pacífico. La mayoría del personal catedrático (69% y asociado (52%, que representan las categorías más altas en RA, obtuvo sus títulos en el exterior, lo que sugiere que los estudios de posgrado fuera del país, son un componente de importancia en la búsqueda de la excelencia académica. La variación y la diversidad de la distribución de los cuadros docentes con formación de posgrado muestran que la internacionalización no ocurre de manera homogénea en las diferentes áreas académicas, por lo que se requieren esfuerzos adicionales para alcanzar equilibrios en la preparación académica de alto nivel.Abstract: This article analyzes the impact of the internationalization process, the different forms and outcomes of academic mobility, upon the Tenure Track System of the University of Costa Rica (UCR.The academic mobility strategy of the UCR focuses on training faculty members in postgraduate programs at universities across the world and its manifestation

  13. Autonomía, autoestima y rendimiento académico

    OpenAIRE

    Franca Fernández, Aroa

    2016-01-01

    Favorecer la autonomía escolar es uno de los objetivos que marcan las políticas educativas que rigen nuestro sistema educativo. Este trabajo parte del presupuesto de que hacer que niños y niñas sean más autónomos en la escuela favorecerá la autoestima y repercutirá positivamente en el rendimiento académico de los alumnos/as. Hacemos un recorrido por estos tres constructos: autonomía, autoestima y rendimiento escolar, argumentamos porqué unos niños son más autónomos que otros y ...

  14. Nucleotide variation at the dopa decarboxylase (Ddc) gene in natural populations of Drosophila melanogaster.

    Science.gov (United States)

    Tatarenkov, Andrey; Ayala, Francisco J

    2007-08-01

    We studied nucleotide sequence variation at the gene coding for dopa decarboxylase (Ddc) in seven populations of Drosophila melanogaster. Strength and pattern of linkage disequilibrium are somewhat distinct in the extensively sampled Spanish and Raleigh populations. In the Spanish population, a few sites are in strong positive association, whereas a large number of sites in the Raleigh population are associated nonrandomly but the association is not strong. Linkage disequilibrium analysis shows presence of two groups of haplotypes in the populations, each of which is fairly diverged, suggesting epistasis or inversion polymorphism. There is evidence of two forms of natural selection acting on Ddc. The McDonald-Kreitman test indicates a deficit of fixed amino acid differences between D. melanogaster and D. simulans, which may be due to negative selection. An excess of derived alleles at high frequency, significant according to the H-test, is consistent with the effect of hitchhiking. The hitchhiking may have been caused by directional selection downstream of the locus studied, as suggested by a gradual decrease of the polymorphism-to-divergence ratio. Altogether, the Ddc locus exhibits a complicated pattern of variation apparently due to several evolutionary forces. Such a complex pattern may be a result of an unusually high density of functionally important genes.

  15. Attachment style and oxytocin receptor gene variation interact in influencing social anxiety.

    Science.gov (United States)

    Notzon, S; Domschke, K; Holitschke, K; Ziegler, C; Arolt, V; Pauli, P; Reif, A; Deckert, J; Zwanzger, P

    2016-01-01

    Social anxiety has been suggested to be promoted by an insecure attachment style. Oxytocin is discussed as a mediator of trust and social bonding as well as a modulator of social anxiety. Applying a gene-environment (G × E) interaction approach, in the present pilot study the main and interactive effects of attachment styles and oxytocin receptor (OXTR) gene variation were probed in a combined risk factor model of social anxiety in healthy probands. Participants (N = 388; 219 females, 169 males; age 24.7 ± 4.7 years) were assessed for anxiety in social situations (Social Phobia and Anxiety Inventory) depending on attachment style (Adult Attachment Scale, AAS) and OXTR rs53576 A/G genotype. A less secure attachment style was significantly associated with higher social anxiety. This association was partly modulated by OXTR genotype, with a stronger negative influence of a less secure attachment style on social anxiety in A allele carriers as compared to GG homozygotes. The present pilot data point to a strong association of less secure attachment and social anxiety as well as to a gene-environment interaction effect of OXTR rs53576 genotype and attachment style on social anxiety possibly constituting a targetable combined risk marker of social anxiety disorder.

  16. Fine Physical Bin Mapping of the Powdery Mildew Resistance Gene Pm21 Based on Chromosomal Structural Variations in Wheat

    Directory of Open Access Journals (Sweden)

    Shanying Zhu

    2018-02-01

    Full Text Available Pm21, derived from wheat wild relative Dasypyrum villosum, is one of the most effective powdery mildew resistance genes and has been widely applied in wheat breeding in China. Mapping and cloning Pm21 are of importance for understanding its resistance mechanism. In the present study, physical mapping was performed using different genetic stocks involving in structural variations of chromosome 6VS carrying Pm21. The data showed that 6VS could be divided into eight distinguishable chromosomal bins, and Pm21 was mapped to the bin FLb4–b5/b6 closely flanked by the markers 6VS-08.6 and 6VS-10.2. Comparative genomic mapping indicated that the orthologous regions of FLb4–b5/b6 carrying Pm21 were narrowed to a 117.7 kb genomic region harboring 19 genes in Brachypodium and a 37.7 kb region harboring 5 genes in rice, respectively. The result was consistent with that given by recent genetic mapping in diploid D. villosum. In conclusion, this study demonstrated that physical mapping based on chromosomal structural variations is an efficient method for locating alien genes in wheat background.

  17. BLENDED-LEARNING e ingeniería: nivel de uso, rendimiento académico y valoración de los alumnos

    Directory of Open Access Journals (Sweden)

    Ana Isabel VÁZQUEZ-MARTÍNEZ

    2014-11-01

    Full Text Available Los cambios que está experimentando la universidad, así como las características de las enseñanzas técnicas, en cuanto a alta tasa de abandono y el bajo rendimiento académico, hacen que se tengan que buscar soluciones para dar respuesta a estos retos. En este artículo se presenta el empleo de la plataforma educativa WebCT en la asignatura Materiales de Construcción-I, en la titulación de Ingeniería de Edificación de la Universidad de Sevilla. Se pretende analizar cuál es el nivel de uso, el rendimiento académico y la valoración que los estudiantes hacen de su uso. De esta manera los objetivos planteados son conocer si el empleo de las herramientas foro y pruebas preparatorias ejerce influencia en el rendimiento de los estudiantes; si existe relación entre el rendimiento y la valoración que los estudiantes hacen de WebCT, y entre el empleo de las herramientas citadas y la valoración dada. Los resultados indican que existen diferencias significativas en el rendimiento académico por el grado de empleo de las pruebas y por el grado de empleo del foro, así como entre la percepción y satisfacción de los estudiantes según el grado de empleo de pruebas y foro. De la misma manera existe correlación entre el rendimiento académico y la valoración que hacen los estudiantes del empleo de WebCT. Por ello se podría decir que la enseñanza presencial apoyada en plataformas educativas puede promover cambios significativos en los resultados académicos, siendo al mismo tiempo un recurso bien valorado por los estudiantes. 

  18. Genetic variation of Taenia pisiformis collected from Sichuan, China, based on the mitochondrial cytochrome B gene.

    Science.gov (United States)

    Yang, Deying; Ren, Yongjun; Fu, Yan; Xie, Yue; Nie, Huaming; Nong, Xiang; Gu, Xiaobin; Wang, Shuxian; Peng, Xuerong; Yang, Guangyou

    2013-08-01

    Taenia pisiformis is one of the most important parasites of canines and rabbits. T. pisiformis cysticercus (the larval stage) causes severe damage to rabbit breeding, which results in huge economic losses. In this study, the genetic variation of T. pisiformis was determined in Sichuan Province, China. Fragments of the mitochondrial cytochrome b (cytb) (922 bp) gene were amplified in 53 isolates from 8 regions of T. pisiformis. Overall, 12 haplotypes were found in these 53 cytb sequences. Molecular genetic variations showed 98.4% genetic variation derived from intra-region. FST and Nm values suggested that 53 isolates were not genetically differentiated and had low levels of genetic diversity. Neutrality indices of the cytb sequences showed the evolution of T. pisiformis followed a neutral mode. Phylogenetic analysis revealed no correlation between phylogeny and geographic distribution. These findings indicate that 53 isolates of T. pisiformis keep a low genetic variation, which provide useful knowledge for monitoring changes in parasite populations for future control strategies.

  19. Estilos de aprendizaje y habilidades de gestión del tiempo académico en Educación Secundaria

    Directory of Open Access Journals (Sweden)

    Francisco Pérez-González

    2003-01-01

    Full Text Available El objetivo principal de este trabajo es analizar la relación entre estilos de aprendizaje, habilidades de gestión del tiempo y resultados académicos en Educación Secundaria. En el estudio participan 111 sujetos que en el curso académico 2000-2001 realizaban sus estudios en Institutos de Educación Secundaria de la Comunidad Valenciana (España, a los que se aplicaron sendas adaptaciones del Inventory of Learning Processes y del TimeManagement Questionnaire y de los que se obtuvieron, adicionalmente, sus resultados académicos. Un análisis correlacional evidencia la estrecha relación entre procesos de aprendizaje y habilidades de gestión de tiempo,tanto entre las puntuaciones globales que ofrecen los instrumentos utilizados como entre las distintas dimensiones específicas que evalúan: Procesamiento Profundo, Procesamiento Elaborativo y Estudio metódico están relacionadascon la actitud de utilizar constructivamente el tiempo de estudio, mientras que los dos últimos también se relacionan con la planificación a corto y largo plazo.Del mismo modo, los análisis de regresión múltiple efectuados destacan quetanto los procesos de aprendizaje como las habilidades de gestión de tiempo son predictores eficaces de los resultados académicos, constatando que los estilos de aprendizaje presentan una capacidad explicativa del rendimiento escolar muy superior a las habilidades de gestión del tiempo.

  20. Candidate gene approach for parasite resistance in sheep--variation in immune pathway genes and association with fecal egg count.

    Directory of Open Access Journals (Sweden)

    Kathiravan Periasamy

    Full Text Available Sheep chromosome 3 (Oar3 has the largest number of QTLs reported to be significantly associated with resistance to gastro-intestinal nematodes. This study aimed to identify single nucleotide polymorphisms (SNPs within candidate genes located in sheep chromosome 3 as well as genes involved in major immune pathways. A total of 41 SNPs were identified across 38 candidate genes in a panel of unrelated sheep and genotyped in 713 animals belonging to 22 breeds across Asia, Europe and South America. The variations and evolution of immune pathway genes were assessed in sheep populations across these macro-environmental regions that significantly differ in the diversity and load of pathogens. The mean minor allele frequency (MAF did not vary between Asian and European sheep reflecting the absence of ascertainment bias. Phylogenetic analysis revealed two major clusters with most of South Asian, South East Asian and South West Asian breeds clustering together while European and South American sheep breeds clustered together distinctly. Analysis of molecular variance revealed strong phylogeographic structure at loci located in immune pathway genes, unlike microsatellite and genome wide SNP markers. To understand the influence of natural selection processes, SNP loci located in chromosome 3 were utilized to reconstruct haplotypes, the diversity of which showed significant deviations from selective neutrality. Reduced Median network of reconstructed haplotypes showed balancing selection in force at these loci. Preliminary association of SNP genotypes with phenotypes recorded 42 days post challenge revealed significant differences (P<0.05 in fecal egg count, body weight change and packed cell volume at two, four and six SNP loci respectively. In conclusion, the present study reports strong phylogeographic structure and balancing selection operating at SNP loci located within immune pathway genes. Further, SNP loci identified in the study were found to have

  1. Gene-based Association Approach Identify Genes Across Stress Traits in Fruit Flies

    DEFF Research Database (Denmark)

    Rohde, Palle Duun; Edwards, Stefan McKinnon; Sarup, Pernille Merete

    Identification of genes explaining variation in quantitative traits or genetic risk factors of human diseases requires both good phenotypic- and genotypic data, but also efficient statistical methods. Genome-wide association studies may reveal association between phenotypic variation and variation...... approach grouping variants accordingly to gene position, thus lowering the number of statistical tests performed and increasing the probability of identifying genes with small to moderate effects. Using this approach we identify numerous genes associated with different types of stresses in Drosophila...... melanogaster, but also identify common genes that affects the stress traits....

  2. Balancing Selection at the Tomato RCR3 Guardee Gene Family Maintains Variation in Strength of Pathogen Defense

    Science.gov (United States)

    Hörger, Anja C.; Ilyas, Muhammad; Stephan, Wolfgang; Tellier, Aurélien; van der Hoorn, Renier A. L.; Rose, Laura E.

    2012-01-01

    Coevolution between hosts and pathogens is thought to occur between interacting molecules of both species. This results in the maintenance of genetic diversity at pathogen antigens (or so-called effectors) and host resistance genes such as the major histocompatibility complex (MHC) in mammals or resistance (R) genes in plants. In plant–pathogen interactions, the current paradigm posits that a specific defense response is activated upon recognition of pathogen effectors via interaction with their corresponding R proteins. According to the “Guard-Hypothesis,” R proteins (the “guards”) can sense modification of target molecules in the host (the “guardees”) by pathogen effectors and subsequently trigger the defense response. Multiple studies have reported high genetic diversity at R genes maintained by balancing selection. In contrast, little is known about the evolutionary mechanisms shaping the guardee, which may be subject to contrasting evolutionary forces. Here we show that the evolution of the guardee RCR3 is characterized by gene duplication, frequent gene conversion, and balancing selection in the wild tomato species Solanum peruvianum. Investigating the functional characteristics of 54 natural variants through in vitro and in planta assays, we detected differences in recognition of the pathogen effector through interaction with the guardee, as well as substantial variation in the strength of the defense response. This variation is maintained by balancing selection at each copy of the RCR3 gene. Our analyses pinpoint three amino acid polymorphisms with key functional consequences for the coevolution between the guardee (RCR3) and its guard (Cf-2). We conclude that, in addition to coevolution at the “guardee-effector” interface for pathogen recognition, natural selection acts on the “guard-guardee” interface. Guardee evolution may be governed by a counterbalance between improved activation in the presence and prevention of auto

  3. Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathogen defense.

    Directory of Open Access Journals (Sweden)

    Anja C Hörger

    Full Text Available Coevolution between hosts and pathogens is thought to occur between interacting molecules of both species. This results in the maintenance of genetic diversity at pathogen antigens (or so-called effectors and host resistance genes such as the major histocompatibility complex (MHC in mammals or resistance (R genes in plants. In plant-pathogen interactions, the current paradigm posits that a specific defense response is activated upon recognition of pathogen effectors via interaction with their corresponding R proteins. According to the "Guard-Hypothesis," R proteins (the "guards" can sense modification of target molecules in the host (the "guardees" by pathogen effectors and subsequently trigger the defense response. Multiple studies have reported high genetic diversity at R genes maintained by balancing selection. In contrast, little is known about the evolutionary mechanisms shaping the guardee, which may be subject to contrasting evolutionary forces. Here we show that the evolution of the guardee RCR3 is characterized by gene duplication, frequent gene conversion, and balancing selection in the wild tomato species Solanum peruvianum. Investigating the functional characteristics of 54 natural variants through in vitro and in planta assays, we detected differences in recognition of the pathogen effector through interaction with the guardee, as well as substantial variation in the strength of the defense response. This variation is maintained by balancing selection at each copy of the RCR3 gene. Our analyses pinpoint three amino acid polymorphisms with key functional consequences for the coevolution between the guardee (RCR3 and its guard (Cf-2. We conclude that, in addition to coevolution at the "guardee-effector" interface for pathogen recognition, natural selection acts on the "guard-guardee" interface. Guardee evolution may be governed by a counterbalance between improved activation in the presence and prevention of auto-immune responses in

  4. Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore.

    Science.gov (United States)

    Lean, Choo Bee; Lee, Edmund Jon Deoon

    2009-01-01

    MCT1(SLC16A1) is the first member of the monocarboxylate transporter (MCT) and its family is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate and ketone bodies. This study identifies genetic variations in SLC16A1 in the ethnic Chinese group of the Singaporean population (n=95). The promoter, coding region and exon-intron junctions of the SLC16A1 gene encoding the MCT1 transporter were screened for genetic variation in the study population by DNA sequencing. Seven genetic variations of SLC16A1, including 4 novel ones, were found: 2 in the promoter region, 2 in the coding exons (both nonsynonymous variations), 2 in the 3' untranslated region (3'UTR) and 1 in the intron. Of the two mutations detected in the promoter region, the -363-855T>C is a novel mutation. The 1282G>A (Val(428)Ile) is a novel SNP and was found as heterozygotic in 4 subjects. The 1470T>A (Asp(490)Glu) was found to be a common polymorphism in this study. Lastly, IVS3-17A>C in intron 3 and 2258 (755)A>G in 3'UTR are novel mutations found to be common polymorphisms in the local Chinese population. To our knowledge, this is the first report of a comprehensive analysis on the MCT1 gene in any population.

  5. Identification of Genes Differentially Expressed During Heat Shock Treatment in Aedes aegypti

    Science.gov (United States)

    2009-01-01

    Chan, C. W. Cheng, and R. S. Wu. 2003. Cloning of theHSP70 gene in barnacle larvae and its expression under hypoxic conditions. Mar. Pollut. Bull. 46...665Ð671. Chuang, K. H., S. H. Ho, and Y. L. Song. 2007. Cloning and expression analysis of heat shock cognate 70 gene pro- moter in tiger shrimp ...in larvae , but not adults, of a polar insect. Proc. Natl. Acad. Sci. U.S.A. 103: 14223Ð14227. Robich, R. M., J. P. Rinehart, L. J. Kitchen, and D. L

  6. Association of the gene expression variation of tumor necrosis factor-α and expressions changes of dopamine receptor genes in progression of diabetic severe foot ulcers

    Directory of Open Access Journals (Sweden)

    Hajar Vaseghi

    2017-11-01

    Full Text Available Objective(s:Regulation of pro-inflammatory factors such as TNF-, which are secreted by the immune cells through induction of their several receptors including dopamine receptors (especially DRD2 and DRD3 is one of the noticeable problems in diabetic severe foot ulcer healing. This study was conducted to evaluate the alteration of TNF- in plasma as well as DRD2 and DRD3 changes in PBMCs of diabetics with severe foot ulcers. Materials and Methods: Peripheral blood samples were collected from 31 subjects with ulcers, 29 without ulcers, and 25 healthy individuals. Total mRNA was extracted from PBMCs for the study of DRD2, DRD3, and TNF- gene expression variations. Expression patterns of these genes were evaluated by real-time PCR. Consequently, concentration of TNF- was investigated in plasma. Results: Significant decrease in gene expression and plasma concentration of TNF- in PBMCs was observed in both patient groups at P Conclusion: We concluded that DRD2 and DRD3 expression alteration and presence of new DRD3 transcripts can be effective in reduction of TNF-α expression as a pro-inflammatory factor. Performing complementary studies, may explain that variations in DRD2 and DRD3 are prognostic and effective markers attributed to the development of diabetes severe foot ulcers.

  7. Clima social escolar y rendimiento académico en comunicación en estudiantes de primaria – Lima, 2014

    OpenAIRE

    Pacheco Villarreal, Rosa Del Pilar

    2014-01-01

    La presente investigación titulada: “Clima Social Escolar y Rendimiento Académico en Comunicación de los estudiantes del V ciclo de primaria de la Institución Educativa N° 1157 Julio César Tello Rojas – Cercado de Lima, 2014”, tuvo como objetivo determinar la relación entre el clima social escolar y el rendimiento académico en comunicación de los estudiantes del V ciclo de primaria. Esto como respuesta al problema: ¿Qué relación existe entre clima social escolar y rendimient...

  8. Prevalencia de Ansiedad y Depresión en una Población de Estudiantes Universitarios: Factores Académicos y Sociofamiliares Asociados

    Directory of Open Access Journals (Sweden)

    Serafín Balanza Galindo

    2009-01-01

    Full Text Available La elevada frecuencia de ansiedad y depresión en estudiantes universitarios está relacionada con factores sociales, familiares y por el estrés académico. El objetivo es analizar la prevalencia de trastornos de ansiedad y depresión y factores académicos y sociofamiliares asociados. El estudio se realizó en una muestra de 700 alumnos, aplicando la Escala de Ansiedad y Depresión de Goldberg (EADG. Como factores de estudio se utilizaron variables que medían diversas situaciones estresantes relacionadas con factores sociofamiliares y académicos. El 47,1% de los estudiantes sufrían trastornos de ansiedad y el 55,6% depresión. En el análisis multivariante, el sexo femenino son quienes presentan mayor riesgo de ansiedad (OR: 2,30 IC 955 1,65-3,19 y de depresión (OR.: 1,98 IC 95% 1,43 -2,76, son estudiantes que realizan largos desplazamientos diarios y tienen otras obligaciones extra académicas, suponiendo mayor riesgo en estudiantes de ciencias jurídicas y de la empresa.

  9. Homenaje de la Academia Nacional de Medicina a la memoria del académico de número profesor Carlos Tirado Macias

    Directory of Open Access Journals (Sweden)

    Facultad de Medicina Revista

    1943-03-01

    Full Text Available En el Salón de la Academia Nacional de Medicina, a las 6 p.m. del día 16 de marzo de 1943, tuvo lugar la sesión especial de la Corporación, en homenaje a la memoria del Académico de Número Profesor Carlos Tirado Macías, bajo la presidencia del Académico Julio Aparicio y con asistencia de los Académicos Manuel Antonio Cuéllar Durán, Arcadio Forero, Carlos Trujillo Gutiérrez, Marco A. Iriarte, Gonzalo Esguerra Gómez, Jorge Bejarano, Francisco Vernaza, Lisandro Leyva Pereira, Manuel Antonio Rueda Vargas, Guillermo Uribe Cualla, Luis Patiño Camargo, y Pablo A. Llinás. Asistieron también a la sesión los parientes del extinto y un numeroso y selecto público.

  10. Average correlation clustering algorithm (ACCA) for grouping of co-regulated genes with similar pattern of variation in their expression values.

    Science.gov (United States)

    Bhattacharya, Anindya; De, Rajat K

    2010-08-01

    Distance based clustering algorithms can group genes that show similar expression values under multiple experimental conditions. They are unable to identify a group of genes that have similar pattern of variation in their expression values. Previously we developed an algorithm called divisive correlation clustering algorithm (DCCA) to tackle this situation, which is based on the concept of correlation clustering. But this algorithm may also fail for certain cases. In order to overcome these situations, we propose a new clustering algorithm, called average correlation clustering algorithm (ACCA), which is able to produce better clustering solution than that produced by some others. ACCA is able to find groups of genes having more common transcription factors and similar pattern of variation in their expression values. Moreover, ACCA is more efficient than DCCA with respect to the time of execution. Like DCCA, we use the concept of correlation clustering concept introduced by Bansal et al. ACCA uses the correlation matrix in such a way that all genes in a cluster have the highest average correlation values with the genes in that cluster. We have applied ACCA and some well-known conventional methods including DCCA to two artificial and nine gene expression datasets, and compared the performance of the algorithms. The clustering results of ACCA are found to be more significantly relevant to the biological annotations than those of the other methods. Analysis of the results show the superiority of ACCA over some others in determining a group of genes having more common transcription factors and with similar pattern of variation in their expression profiles. Availability of the software: The software has been developed using C and Visual Basic languages, and can be executed on the Microsoft Windows platforms. The software may be downloaded as a zip file from http://www.isical.ac.in/~rajat. Then it needs to be installed. Two word files (included in the zip file) need to

  11. Balancing selection and recombination as evolutionary forces caused population genetic variations in golden pheasant MHC class I genes.

    Science.gov (United States)

    Zeng, Qian-Qian; He, Ke; Sun, Dan-Dan; Ma, Mei-Ying; Ge, Yun-Fa; Fang, Sheng-Guo; Wan, Qiu-Hong

    2016-02-18

    The major histocompatibility complex (MHC) genes are vital partners in the acquired immune processes of vertebrates. MHC diversity may be directly associated with population resistance to infectious pathogens. Here, we screened for polymorphisms in exons 2 and 3 of the IA1 and IA2 genes in 12 golden pheasant populations across the Chinese mainland to characterize their genetic variation levels, to understand the effects of historical positive selection and recombination in shaping class I diversity, and to investigate the genetic structure of wild golden pheasant populations. Among 339 individual pheasants, we identified 14 IA1 alleles in exon 2 (IA1-E2), 11 IA1-E3 alleles, 27 IA2-E2 alleles, and 28 IA2-E3 alleles. The non-synonymous substitution rate was significantly greater than the synonymous substitution rate at sequences in the IA2 gene encoding putative peptide-binding sites but not in the IA1 gene; we also found more positively selected sites in IA2 than in IA1. Frequent recombination events resulted in at least 9 recombinant IA2 alleles, in accordance with the intermingling pattern of the phylogenetic tree. Although some IA alleles are widely shared among studied populations, large variation occurs in the number of IA alleles across these populations. Allele frequency analysis across 2 IA loci showed low levels of genetic differentiation among populations on small geographic scales; however, significant genetic differentiation was observed between pheasants from the northern and southern regions of the Yangtze River. Both STRUCTURE analysis and F-statistic (F ST ) value comparison classified those populations into 2 major groups: the northern region of the Yangtze River (NYR) and the southern region of the Yangtze River (SYR). More extensive polymorphisms in IA2 than IA1 indicate that IA2 has undergone much stronger positive-selection pressure during evolution. Moreover, the recombination events detected between the genes and the intermingled phylogenetic

  12. Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.

    Science.gov (United States)

    Gu, Fangyi; Zhang, Han; Hyland, Paula L; Berndt, Sonja; Gapstur, Susan M; Wheeler, William; Ellipse Consortium, The; Amos, Christopher I; Bezieau, Stephane; Bickeböller, Heike; Brenner, Hermann; Brennan, Paul; Chang-Claude, Jenny; Conti, David V; Doherty, Jennifer Anne; Gruber, Stephen B; Harrison, Tabitha A; Hayes, Richard B; Hoffmeister, Michael; Houlston, Richard S; Hung, Rayjean J; Jenkins, Mark A; Kraft, Peter; Lawrenson, Kate; McKay, James; Markt, Sarah; Mucci, Lorelei; Phelan, Catherine M; Qu, Conghui; Risch, Angela; Rossing, Mary Anne; Wichmann, H-Erich; Shi, Jianxin; Schernhammer, Eva; Yu, Kai; Landi, Maria Teresa; Caporaso, Neil E

    2017-11-01

    Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic Associations and Mechanisms in Oncology (GAME-ON) network. The major results for prostate cancer were replicated in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, and for colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). The total number of cancer cases and controls was 15,838/18,159 for colorectal, 14,818/14,227 for prostate, 12,537/17,285 for lung and 4,369/9,123 for ovary. For each cancer site, we conducted gene-based and pathway-based analyses by applying the summary-based Adaptive Rank Truncated Product method (sARTP) on the summary association statistics for each SNP within the candidate gene regions. Aggregate genetic variation in circadian rhythm and melatonin pathways were significantly associated with the risk of prostate cancer in data combining GAME-ON and PLCO, after Bonferroni correction (p pathway  circadian rhythm pathway in GAME-ON (p pathway  = 0.021); this association was not confirmed in GECCO (p pathway  = 0.76) or the combined data (p pathway  = 0.17). No significant association was observed for ovarian and lung cancer. These findings support a potential role for circadian rhythm and melatonin pathways in prostate carcinogenesis. Further functional studies are needed to better understand the underlying biologic mechanisms. © 2017 UICC.

  13. Conducta prosocial y motivación académica en estudiantes españoles de Educación Secundaria Obligatoria

    OpenAIRE

    INGLÉS, CÁNDIDO J; MARTÍNEZ-GONZÁLEZ, AGUSTÍN E; VALLE, ANTONIO; GRACÍA-FERNÁNDEZ, JOSÉ M; RUIZ-ESTEBAN, CECILIA

    2011-01-01

    Este estudio analizó la relación entre conducta prosocial y metas académicas en una muestra de 2.022 estudiantes españoles. La conducta prosocial fue medida con la escala de conducta prosocial del Teenage Inventory of Social Skills (TISS) y las metas académicas mediante el Achievement Goal Tendencies Questionnaire (AGTQ). Los resultados revelaron que los estudiantes con alta conducta prosocial presentaron puntuaciones significativamente más altas en metas de aprendizaje y logro. La conducta p...

  14. Variation of antibiotic resistance genes in municipal wastewater treatment plant with A(2)O-MBR system.

    Science.gov (United States)

    Du, Jing; Geng, Jinju; Ren, Hongqiang; Ding, Lili; Xu, Ke; Zhang, Yan

    2015-03-01

    The variation of five antibiotic resistance genes (ARGs)-tetG, tetW, tetX, sul1, and intI1-in a full-scale municipal wastewater treatment plant with A(2)O-MBR system was studied. The concentrations of five resistance genes both in influent and in membrane bioreactor (MBR) effluent decreased as sul1 > intI1 > tetX > tetG > tetW, and an abundance of sul1 was statistically higher than three other tetracycline resistance genes (tetG, tetW, and tetX) (p MBR effluent. The reduction of tetW, intI1, and sul1 was all significantly positively correlated with the reduction of 16S ribosomal DNA (rDNA) in the wastewater treatment process (p MBR was observed for all ARGs.

  15. Wild rodents as a model to discover genes and pathways underlying natural variation in infectious disease susceptibility.

    Science.gov (United States)

    Turner, A K; Paterson, S

    2013-11-01

    Individuals vary in their susceptibility to infectious disease, and it is now well established that host genetic factors form a major component of this variation. The discovery of genes underlying susceptibility has the potential to lead to improved disease control, through the identification and management of vulnerable individuals and the discovery of novel therapeutic targets. Laboratory rodents have proved invaluable for ascertaining the function of genes involved in immunity to infection. However, these captive animals experience conditions very different to the natural environment, lacking the genetic diversity and environmental pressures characteristic of natural populations, including those of humans. It has therefore often proved difficult to translate basic laboratory research to the real world. In order to further our understanding of the genetic basis of infectious disease resistance, and the evolutionary forces that drive variation in susceptibility, we propose that genetic research traditionally conducted on laboratory animals is expanded to the more ecologically valid arena of natural populations. In this article, we highlight the potential of using wild rodents as a new resource for biomedical research, to link the functional genetic knowledge gained from laboratory rodents with the variation in infectious disease susceptibility observed in humans and other natural populations. © 2013 John Wiley & Sons Ltd.

  16. Homoeologous exchange is a major cause of gene presence/absence variation in the amphidiploid Brassica napus.

    Science.gov (United States)

    Hurgobin, Bhavna; Golicz, Agnieszka A; Bayer, Philipp E; Chan, Chon-Kit Kenneth; Tirnaz, Soodeh; Dolatabadian, Aria; Schiessl, Sarah V; Samans, Birgit; Montenegro, Juan D; Parkin, Isobel A P; Pires, J Chris; Chalhoub, Boulos; King, Graham J; Snowdon, Rod; Batley, Jacqueline; Edwards, David

    2018-07-01

    Homoeologous exchanges (HEs) have been shown to generate novel gene combinations and phenotypes in a range of polyploid species. Gene presence/absence variation (PAV) is also a major contributor to genetic diversity. In this study, we show that there is an association between these two events, particularly in recent Brassica napus synthetic accessions, and that these represent a novel source of genetic diversity, which can be captured for the improvement of this important crop species. By assembling the pangenome of B. napus, we show that 38% of the genes display PAV behaviour, with some of these variable genes predicted to be involved in important agronomic traits including flowering time, disease resistance, acyl lipid metabolism and glucosinolate metabolism. This study is a first and provides a detailed characterization of the association between HEs and PAVs in B. napus at the pangenome level. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  17. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

    Science.gov (United States)

    Chornokur, Ganna; Lin, Hui-Yi; Tyrer, Jonathan P; Lawrenson, Kate; Dennis, Joe; Amankwah, Ernest K; Qu, Xiaotao; Tsai, Ya-Yu; Jim, Heather S L; Chen, Zhihua; Chen, Ann Y; Permuth-Wey, Jennifer; Aben, Katja K H; Anton-Culver, Hoda; Antonenkova, Natalia; Bruinsma, Fiona; Bandera, Elisa V; Bean, Yukie T; Beckmann, Matthias W; Bisogna, Maria; Bjorge, Line; Bogdanova, Natalia; Brinton, Louise A; Brooks-Wilson, Angela; Bunker, Clareann H; Butzow, Ralf; Campbell, Ian G; Carty, Karen; Chang-Claude, Jenny; Cook, Linda S; Cramer, Daniel W; Cunningham, Julie M; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; du Bois, Andreas; Despierre, Evelyn; Dicks, Ed; Doherty, Jennifer A; Dörk, Thilo; Dürst, Matthias; Easton, Douglas F; Eccles, Diana M; Edwards, Robert P; Ekici, Arif B; Fasching, Peter A; Fridley, Brooke L; Gao, Yu-Tang; Gentry-Maharaj, Aleksandra; Giles, Graham G; Glasspool, Rosalind; Goodman, Marc T; Gronwald, Jacek; Harrington, Patricia; Harter, Philipp; Hein, Alexander; Heitz, Florian; Hildebrandt, Michelle A T; Hillemanns, Peter; Hogdall, Claus K; Hogdall, Estrid; Hosono, Satoyo; Jakubowska, Anna; Jensen, Allan; Ji, Bu-Tian; Karlan, Beth Y; Kelemen, Linda E; Kellar, Mellissa; Kiemeney, Lambertus A; Krakstad, Camilla; Kjaer, Susanne K; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D; Lee, Alice W; Lele, Shashi; Leminen, Arto; Lester, Jenny; Levine, Douglas A; Liang, Dong; Lim, Boon Kiong; Lissowska, Jolanta; Lu, Karen; Lubinski, Jan; Lundvall, Lene; Massuger, Leon F A G; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R; McNeish, Iain; Menon, Usha; Milne, Roger L; Modugno, Francesmary; Moysich, Kirsten B; Ness, Roberta B; Nevanlinna, Heli; Eilber, Ursula; Odunsi, Kunle; Olson, Sara H; Orlow, Irene; Orsulic, Sandra; Weber, Rachel Palmieri; Paul, James; Pearce, Celeste L; Pejovic, Tanja; Pelttari, Liisa M; Pike, Malcolm C; Poole, Elizabeth M; Risch, Harvey A; Rosen, Barry; Rossing, Mary Anne; Rothstein, Joseph H; Rudolph, Anja; Runnebaum, Ingo B; Rzepecka, Iwona K; Salvesen, Helga B; Schernhammer, Eva; Schwaab, Ira; Shu, Xiao-Ou; Shvetsov, Yurii B; Siddiqui, Nadeem; Sieh, Weiva; Song, Honglin; Southey, Melissa C; Spiewankiewicz, Beata; Sucheston, Lara; Teo, Soo-Hwang; Terry, Kathryn L; Thompson, Pamela J; Thomsen, Lotte; Tangen, Ingvild L; Tworoger, Shelley S; van Altena, Anne M; Vierkant, Robert A; Vergote, Ignace; Walsh, Christine S; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S; Wicklund, Kristine G; Wilkens, Lynne R; Wu, Anna H; Wu, Xifeng; Woo, Yin-Ling; Yang, Hannah; Zheng, Wei; Ziogas, Argyrios; Hasmad, Hanis N; Berchuck, Andrew; Iversen, Edwin S; Schildkraut, Joellen M; Ramus, Susan J; Goode, Ellen L; Monteiro, Alvaro N A; Gayther, Simon A; Narod, Steven A; Pharoah, Paul D P; Sellers, Thomas A; Phelan, Catherine M

    2015-01-01

    Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q<0.2 was applied to adjust for multiple comparisons. The most significant evidence of an association for all invasive cancers combined and for the serous subtype was observed for SNP rs17216603 in the iron transporter gene HEPH (invasive: OR = 0.85, P = 0.00026; serous: OR = 0.81, P = 0.00020); this SNP was also associated with the borderline/low malignant potential (LMP) tumors (P = 0.021). Other genes significantly associated with EOC histological subtypes (p<0.05) included the UGT1A (endometrioid), SLC25A45 (mucinous), SLC39A11 (low malignant potential), and SERPINA7 (clear cell carcinoma). In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A) were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects. The most significant imputed SNP was rs117729793 in SLC39A11 (per allele, OR = 2.55, 95% CI = 1.5-4.35, p = 5.66x10-4). These results, generated on a large cohort of women, revealed associations between inherited cellular transport

  18. Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion.

    Science.gov (United States)

    Brayton, Kelly A; Palmer, Guy H; Lundgren, Anna; Yi, Jooyoung; Barbet, Anthony F

    2002-03-01

    The rickettsial pathogen Anaplasma marginale establishes lifelong persistent infection in the mammalian reservoir host, during which time immune escape variants continually arise in part because of variation in the expressed copy of the immunodominant outer membrane protein MSP2. A key question is how the small 1.2 Mb A. marginale genome generates sufficient variants to allow long-term persistence in an immunocompetent reservoir host. The recombination of whole pseudogenes into the single msp2 expression site has been previously identified as one method of generating variants, but is inadequate to generate the number of variants required for persistent infection. In the present study, we demonstrate that recombination of a whole pseudogene is followed by a second level of variation in which small segments of pseudogenes recombine into the expression site by gene conversion. Evidence for four short sequential changes in the hypervariable region of msp2 coupled with the identification of nine pseudogenes from a single strain of A. marginale provides for a combinatorial number of possible expressed MSP2 variants sufficient for lifelong persistence.

  19. Calidad del rendimiento académico de estudiantes de Matemática de la Facultad de Ciencias Naturales y Matemática - Universidad Nacional del Callao

    OpenAIRE

    Caycho Myma, Manco

    2014-01-01

    Conociendo las características académicas de nuestros estudiantes se podrá tomar decisiones sobre sus fortalezas y debilidades; una forma desde hace varios años utilizada (Bottani, 1998) es calculando y analizando diversos indicadores relacionados al rendimiento académico de los estudiantes, así .como también conociendo la valoración y autoevaluación de los procesos de enseñanza-aprendizaje relacionados con el rendimiento académico. Desde esta perspectiva y sobre la base de los criterios e in...

  20. Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato.

    Directory of Open Access Journals (Sweden)

    Riccardo Papa

    Full Text Available Recent studies indicate that relatively few genomic regions are repeatedly involved in the evolution of Heliconius butterfly wing patterns. Although this work demonstrates a number of cases where homologous loci underlie both convergent and divergent wing pattern change among different Heliconius species, it is still unclear exactly how many loci underlie pattern variation across the genus. To address this question for Heliconius erato, we created fifteen independent crosses utilizing the four most distinct color pattern races and analyzed color pattern segregation across a total of 1271 F2 and backcross offspring. Additionally, we used the most variable brood, an F2 cross between H. himera and the east Ecuadorian H. erato notabilis, to perform a quantitative genetic analysis of color pattern variation and produce a detailed map of the loci likely involved in the H. erato color pattern radiation. Using AFLP and gene based markers, we show that fewer major genes than previously envisioned control the color pattern variation in H. erato. We describe for the first time the genetic architecture of H. erato wing color pattern by assessing quantitative variation in addition to traditional linkage mapping. In particular, our data suggest three genomic intervals modulate the bulk of the observed variation in color. Furthermore, we also identify several modifier loci of moderate effect size that contribute to the quantitative wing pattern variation. Our results are consistent with the two-step model for the evolution of mimetic wing patterns in Heliconius and support a growing body of empirical data demonstrating the importance of major effect loci in adaptive change.

  1. Autonomía y ajuste académico: un estudio con estudiantes portugueses de primer año

    Directory of Open Access Journals (Sweden)

    Ana Paula Soares

    2007-01-01

    Full Text Available Los niveles de autonomía psicológica de los alumnos desempeñan un papel importante en su ajuste a las presiones y desafíos de la vida universitaria. En este sentido, el presente estudio descriptivo analiza las relaciones entre los niveles de autonomía de los estudiantes en su entrada en la Enseñanza Superior y la calidad de su ajuste académico al final del primer año. Se aplicó el Iowa Developing Autonomy Inventory (IDAI en el inicio del año lectivo y el Questionário de Vivências Académicas (QVA al final de ese año a una muestra de 420 alumnos de primer año de la Universidade do Minho. Los resultados revelan que los alumnos poseen percepciones bastante positivas en cuanto a sus niveles de autonomía en las áreas de Gestión del tiempo, Movilidad e Interdependencia, y niveles más bajos en la Gestión del dinero, observándose algunas oscilaciones en función del género. Por otro lado, los alumnos cuya entrada en la Enseñanza Superior no implicó su abandono del hogar familiar, especialmente los de sexo masculino, presentan niveles más elevados de ajuste académico. Finalmente, los resultados sugieren que el ajuste académico se encuentra asociado a los niveles de autonomía de los alumnos, en particular en lo que concierne a la Gestión del tiempo, Independencia emocional de sus compañeros e Interdependencia.

  2. Relación entre factores académicos y consumo de videojuegos en universitarios. Un modelo de regresión

    OpenAIRE

    Chacón Cubero, Ramón; Zurita Ortega, Félix; Martínez Martínez, Asunción; Castro Sánchez, Manuel; Espejo Garcés, Tamara; Pinel Martínez, Cristina

    2017-01-01

    Las Tecnologías de la Información y Comunicación (TIC) han adquirido una fuerte presencia en la vida cotidiana, constituyendo un factor modulador de los logros académicos y profesionales en la etapa universitaria. Este estudio de diseño descriptivo y corte transversal, realizado sobre 490 estudiantes de la Universidad de Granada, pretende determinar patrones de relación entre el rendimiento académico y los hábitos de consumo de videojuegos, utilizando como principales instrumentos un cuest...

  3. Asociación entre las habilidades mentales primarias y el rendimiento académico en estudiantes de medicina de pregrado

    OpenAIRE

    Víctor Manuel Gómez-López; Sandra Rosales-Gracia; Griselda Marín-Solórzano

    2013-01-01

    Con el propósito de analizar la asociación que existe entre las habilidades mentales primarias cuando se ingresa a la carrera de medicina y el rendimiento académico cuando se termina el octavo semestre, se realizó un estudio observacional y retrospectivo en 121 egresados de la Licenciatura de Medicina de una escuela particular del norte de México. Las habilidades mentales primarias se consideraron como variables predictoras, en tanto el rendimiento académico se asumió como variables de result...

  4. Creatividad, función ejecutiva y rendimiento académico: un estudio correlacional en educación secundaria

    OpenAIRE

    Camargo-Reina, Karol Tatiana

    2014-01-01

    El objetivo de este Trabajo fin de Máster ha sido caracterizar la integración visomotora de un grupo de niños con TDAH; y determinar la relación entre TDAH y dificultades académicas. Para ello se seleccionó un grupo de niños con TDAH y un grupo control, se aplicó el Beery VMI y una encuesta. Resultados: se encontró que el desempeño del Beery VMI fué bajo y muy bajo en el grupo con TDAH; medio y alto en el grupo control. Se identificaron más niños con problemas académicos en ...

  5. Una hipótesis sobre la relación entre estilos de aprendizaje y autoeficacia académica

    Directory of Open Access Journals (Sweden)

    Pedro O. Laffita- Azpiazú

    2017-01-01

    Full Text Available La población estudiada muestra una tendencia predominante hacia el estilo de aprendizaje activo y bajos niveles de autoeficacia académica. El artículo expone una hipótesis sobre el por qué no se obtienen los resultados esperados, aun cuando la enseñanza se diseñó tomando en cuenta el estilo de aprendizaje que predomina. Se demuestra la necesidad de profundizar en la influencia que puede ejercer el nivel de autoeficacia académica de una persona en la manifestación de las características propias del estilo de aprendizaje hacia el cual revela una tendencia predominante.

  6. Estudio del rendimiento académico en atletas adolescentes del Club de Atletismo Playas de Castellón

    OpenAIRE

    Capdevila Seder, Ana; Bellmunt Villalonga, Hector; Hernando Domingo, Carlos

    2014-01-01

    El estudio analizó la posible relación entre el rendimiento académico de jóvenes atletas y algunas de las variables más utilizadas en este campo. La muestra estaba compuesta por 40 atletas del Club de Atletismo Playas de Castellón, con edades comprendidas entre 14 y 16 años, 22 hombres y 18 mujeres. Las principales variables analizadas fueron el rendimiento académico, los hábitos de estudio, el género, las horas de sueño, el ocio sedentario, el nivel socioeconómico y la dedicación al deporte....

  7. La mayéutica como estrategia en el proceso de asesoría académica

    Directory of Open Access Journals (Sweden)

    Camila Peñuela Traslaviña

    2017-01-01

    Full Text Available Se presenta una experiencia en el ámbito de la gestión educativa, la cual consiste en la aplicación de la mayéutica como estrategia fundamental en el proceso de asesoría académica en la Universidad Nacional Abierta, Centro Local Zulia. Se realiza un esbozo del método socrático, se señalan los motivos y la forma de aplicación dentro de la asesoría académica, y se exponen los resultados obtenidos con el uso de esta herramienta: progresiva asimilación del método por parte de los estudiantes, evidencia de su efectividad en la calidad de los trabajos presentados y en la capacidad para construir y expresar sus propias ideas.

  8. Perfis de carreira: exploração vocacional, adaptação acadêmica e personalidade

    Directory of Open Access Journals (Sweden)

    Liliana Faria

    2014-01-01

    Full Text Available Este estudio analiza la relación entre los procesos de exploración de carreras, el ajuste académico y la personalidad, para identificar perfiles de carrera. Han par - ticipado 115 estudiantes, 72 mujeres y 43 hombres, del primer ciclo de la edu - cación superior portugués. Se aplicó el Career Exploration Survey, el Academic Adjustment Questionnaire y el The Revised NEO Personality Inventory. Se han identificado dos perfiles diferentes de actividad y de experiencia de carreras. El perfil conformista que muestra niveles negativos de creencias, comportamientos y reacciones de la exploración. Por otro lado, el perfil constructivo presenta niveles positivos en todos los aspectos de la exploración y ajuste académico, y sólo un factor de conscienciosidad positivo.

  9. Autorregulación, Resiliencia y Metas Educativas: Variables Protectoras del Rendimiento Académico de Bachilleres

    Directory of Open Access Journals (Sweden)

    JOSÉ CONCEPCIÓN GAXIOLA ROMERO

    2013-01-01

    Full Text Available En México, el rendimiento académico de bachillerato es deficiente, por lo que es necesario estudiar sus variables predictoras para mejorarlo. El objetivo del estudio fue medir las trayectorias entre las variables autorregulación, resiliencia y metas educativas en el rendimiento académico de estudiantes de bachillerato, ante la percepción del comportamiento de riesgo de los amigos y la percepción del ambiente escolar de riesgo. Se entrevistaron 120 estudiantes de bachillerato con el más bajo aprovechamiento de la ciudad de Hermosillo, Sonora, México. El análisis de trayectorias indica que las variables estudiadas protegen a los estudiantes de los efectos negativos de la percepción del contexto escolar de riesgo y las amistades de riesgo.

  10. Autoconcepto y Talento: Una Relación que Favorece el Logro Académico Self-Concept and Talent: A Connection That Promotes Academic Achievement

    Directory of Open Access Journals (Sweden)

    María de la Luz González

    2012-05-01

    Full Text Available En este artículo se presentan los resultados de un estudio cuyo objetivo fue estimar la asociación entre autoconcepto y talento académico con los resultados académicos en lenguaje y matemática de alumnos de contextos socioeconómicos vulnerables. Se utilizó una metodología cuantitativa con un diseño correlacional y una muestra intencionada. Se recolectaron los datos a través de pruebas alineadas al currículum (Sistema de Evaluación del Progreso en el Aprendizaje SEPA, un test de inteligencia práctica, creativa y analítica y un cuestionario de autoconcepto académico, aplicados a 1411 alumnos, y un cuestionario aplicado a 1411 apoderados. Los resultados, obtenidos por medio de t de Student y modelos de regresión múltiple, apoyan la asociación entre expectativas académicas, autoconcepto y talento académico y sugieren que estos 3 elementos conforman un círculo virtuoso que permite a los alumnos obtener buenos resultados académicos.This article presents the results of a study that estimates the association between self-esteem and academic talent, using the academic results for language and math of students in vulnerable socioeconomic conditions. A correlational design with quantitative methodology and an intentional sample were used. Data were collected through tests that follow the curriculum (Assessment System of Progress in Learning SEPA, a practical, creative and analytic intelligence test, a questionnaire on academic self-concept applied to 1411 students, and a questionnaire applied to 1411 parents and/or legal guardians. The results, obtained via the use of Student's t and multiple regression models, support the association between academic expectations, self-concept, and academic talent and suggest that these 3 elements form a virtuous cycle that fosters good academic performance.

  11. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7

    Energy Technology Data Exchange (ETDEWEB)

    Duggirala, R.; Stern, M.P.; Reinhart, L.J. [Univ. of Texas Health Science Center, San Antonio, TX (United States)] [and others

    1996-09-01

    Despite the evidence that human obesity has strong genetic determinants, efforts at identifying specific genes that influence human obesity have largely been unsuccessful. Using the sibship data obtained from 32 low-income Mexican American pedigrees ascertained on a type II diabetic proband and a multipoint variance-components method, we tested for linkage between various obesity-related traits plus associated metabolic traits and 15 markers on human chromosome 7. We found evidence for linkage between markers in the OB gene region and various traits, as follows: D7S514 and extremity skinfolds (LOD = 3.1), human carboxypeptidase A1 (HCPA1) and 32,33-split proinsulin level (LOD = 4.2), and HCPA1 and proinsulin level (LOD = 3.2). A putative susceptibility locus linked to the marker D7S514 explained 56% of the total phenotypic variation in extremity skinfolds. Variation at the HCPA1 locus explained 64% of phenotypic variation in proinsulin level and {approximately}73% of phenotypic variation in split proinsulin concentration, respectively. Weaker evidence for linkage to several other obesity-related traits (e.g., waist circumference, body-mass index, fat mass by bioimpedance, etc.) was observed for a genetic location, which is {approximately}15 cM telomeric to OB. In conclusion, our study reveals that the OB region plays a significant role in determining the phenotypic variation of both insulin precursors and obesity-related traits, at least in Mexican Americans. 66 refs., 3 figs., 4 tabs.

  12. Friedrich Creuzer (1771-1858 à l’Académie des Inscriptions et Belles-Lettres

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    Sotera Fornaro

    2010-12-01

    Full Text Available La contribution donnera une vue d’ensemble des relations personnelles et culturelles qui ont déterminé la réception dans la culture française de l’œuvre Symbolik und Mythologie de Friedrich Creuzer (1771-1858. L’élection de Creuzer comme membre de l’Académie des Inscriptions et Belles-Lettres en 1825 y constituera l’épisode central qui s’inscrit dans un cadre plus large du « transfert culturel » franco-allemand.Pour sa réception en France, Sylvestre de Sacy, président de la Société Asiatique, jouait un rôle décisif. C’est surtout grâce à son initiative que Creuzer fut élu membre de l’Académie des Inscriptions où il devenait, en 1826, le successeur du fameux Friedrich August Wolf et fut accueilli au même moment que Wilhelm von Humboldt, une coïncidence qui porta à Creuzer une estime incontestable qu’en Allemagne, il lui manquait. La querelle de méthode que sa Symbolique avait provoquée en Allemagne y conduisit à une marginalisation dans la philologie classique officielle. De plus, il fut accusé de « cryptocatholicisme », de « trahison » de la foi protestante et, d’une façon implicite, d’adhésion à la maçonnerie. En France, jusqu’à sa réception à l’Académie, Creuzer n’était pas connu pour sa Symbolique, mais plutôt pour ses travaux sur l’historiographie antique et ses éditions de Cicéron. Pendant son séjour à l’Académie des Inscriptions à Paris en 1827, il s’efforçait, d’après ses propres notes autobiographiques, d’éviter des débats sur la mythologie ou la religion et de se présenter comme chercheur strictement historique. À Paris, il approfondit ses recherches orientales en entrant en contact avec Félix Lajard, Eugène Burnouf et Edgar Quinet. Creuzer y rencontra aussi son traducteur Jean Daniel Guigniaut qui allait travailler plus de 25 ans à la traduction et récriture de la Symbolique. La révision de Guigniaut eut une influence énorme dans la

  13. Correlación de inteligencia emocional con bienestar psicológico y rendimiento académico en alumnos de licenciatura

    OpenAIRE

    Sánchez-López, Dolores; León-Hernández, Saúl Renán; Barragán-Velásquez, Clemente

    2015-01-01

    IntroducciónExisten numerosos estudios que destacan la relación de la inteligencia emocional con el desempeño académico; sin embargo, la mayoría de los instrumentos empleados para medir la inteligencia emocional han sido diseñados y validados para poblaciones diferentes a la mexicana. Hasta la fecha, no existe estudio alguno que correlacione la Escala de Bienestar Psicológico con la del Perfil de Inteligencia Emocional, diseñada en México, y analice su probable relación en el rendimiento acad...

  14. Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease.

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    Jacqueline Stockley

    Full Text Available The clinical expression of type 1 von Willebrand disease may be modified by co-inheritance of other mild bleeding diatheses. We previously showed that mutations in the platelet P2Y12 ADP receptor gene (P2RY12 could contribute to the bleeding phenotype in patients with type 1 von Willebrand disease. Here we investigated whether variations in platelet G protein-coupled receptor genes other than P2RY12 also contributed to the bleeding phenotype. Platelet G protein-coupled receptor genes P2RY1, F2R, F2RL3, TBXA2R and PTGIR were sequenced in 146 index cases with type 1 von Willebrand disease and the potential effects of identified single nucleotide variations were assessed using in silico methods and heterologous expression analysis. Seven heterozygous single nucleotide variations were identified in 8 index cases. Two single nucleotide variations were detected in F2R; a novel c.-67G>C transversion which reduced F2R transcriptional activity and a rare c.1063C>T transition predicting a p.L355F substitution which did not interfere with PAR1 expression or signalling. Two synonymous single nucleotide variations were identified in F2RL3 (c.402C>G, p.A134 =; c.1029 G>C p.V343 =, both of which introduced less commonly used codons and were predicted to be deleterious, though neither of them affected PAR4 receptor expression. A third single nucleotide variation in F2RL3 (c.65 C>A; p.T22N was co-inherited with a synonymous single nucleotide variation in TBXA2R (c.6680 C>T, p.S218 =. Expression and signalling of the p.T22N PAR4 variant was similar to wild-type, while the TBXA2R variation introduced a cryptic splice site that was predicted to cause premature termination of protein translation. The enrichment of single nucleotide variations in G protein-coupled receptor genes among type 1 von Willebrand disease patients supports the view of type 1 von Willebrand disease as a polygenic disorder.

  15. Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease.

    Science.gov (United States)

    Stockley, Jacqueline; Nisar, Shaista P; Leo, Vincenzo C; Sabi, Essa; Cunningham, Margaret R; Eikenboom, Jeroen C; Lethagen, Stefan; Schneppenheim, Reinhard; Goodeve, Anne C; Watson, Steve P; Mundell, Stuart J; Daly, Martina E

    2015-01-01

    The clinical expression of type 1 von Willebrand disease may be modified by co-inheritance of other mild bleeding diatheses. We previously showed that mutations in the platelet P2Y12 ADP receptor gene (P2RY12) could contribute to the bleeding phenotype in patients with type 1 von Willebrand disease. Here we investigated whether variations in platelet G protein-coupled receptor genes other than P2RY12 also contributed to the bleeding phenotype. Platelet G protein-coupled receptor genes P2RY1, F2R, F2RL3, TBXA2R and PTGIR were sequenced in 146 index cases with type 1 von Willebrand disease and the potential effects of identified single nucleotide variations were assessed using in silico methods and heterologous expression analysis. Seven heterozygous single nucleotide variations were identified in 8 index cases. Two single nucleotide variations were detected in F2R; a novel c.-67G>C transversion which reduced F2R transcriptional activity and a rare c.1063C>T transition predicting a p.L355F substitution which did not interfere with PAR1 expression or signalling. Two synonymous single nucleotide variations were identified in F2RL3 (c.402C>G, p.A134 =; c.1029 G>C p.V343 =), both of which introduced less commonly used codons and were predicted to be deleterious, though neither of them affected PAR4 receptor expression. A third single nucleotide variation in F2RL3 (c.65 C>A; p.T22N) was co-inherited with a synonymous single nucleotide variation in TBXA2R (c.6680 C>T, p.S218 =). Expression and signalling of the p.T22N PAR4 variant was similar to wild-type, while the TBXA2R variation introduced a cryptic splice site that was predicted to cause premature termination of protein translation. The enrichment of single nucleotide variations in G protein-coupled receptor genes among type 1 von Willebrand disease patients supports the view of type 1 von Willebrand disease as a polygenic disorder.

  16. ¿Cómo cambian los niveles de extensibilidad isquiosural de los estudiantes durante un año académico? Un estudio longitudinal

    Directory of Open Access Journals (Sweden)

    Carlos A. Becerra-Fernández

    2017-12-01

    Full Text Available El objetivo principal del presente estudio fue examinar los niveles de extensibilidad isquiosural de los estudiantes durante un curso académico. Una muestra de 128 estudiantes de 1º de bachillerato de un centro de educación secundaria se evaluó mediante la prueba de classic sit-and-reach al comienzo, mediados y final del curso académico. Los resultados mostraron que el nivel de extensibilidad de isquiosural de los estudiantes disminuyó estadísticamente significativamente desde el comienzo (22,1 ± 8,5 cm a mediados (19,9 ± 8,6 cm, d = -0,26 y final del año académico (18,6 ± 9,3 cm; d = -0,41 (p < 0,001, y desde mediados al final (d = -0.16 (p < 0,001. Los resultados de la prueba de McNemar indicaron que hubo una disminución estadísticamente significativa en la proporción de estudiantes con un nivel de extensibilidad isquiosural normal desde el comienzo al final del curso académico (p < 0,05. En conclusión, los estudiantes de educación secundaria perdieron niveles de extensibilidad isquiosural durante un curso académico. Como resultado de esta disminución, el número de estudiantes con acortamiento de los músculos isquiosurales aumentó un 10,9%. Los profesores de educación física deberían implementar programas de estiramiento para prevenir el acortamiento de extensibilidad isquiosural de los estudiantes.

  17. Modelo integrado de gestión académica para promover ventajas competitivas en la universidad : Aplicación del enfoque de gestión del conocimiento

    OpenAIRE

    Sosa, Mabel; Velázquez, Isabel; Silva, Carmen; Zarco, Raquel; Rodríguez, Carlos

    2008-01-01

    Este trabajo plantea como objetivo desarrollar un Modelo de gestión académica soportado por el enfoque de gestión de conocimiento que permita re-usar el conocimiento producido y acumulado facilitando el aprendizaje académico organizacional. El modelo incorpora una estrategia organizacional que utiliza las Tecnologías de la Información y del Conocimiento para optimizar la función académica de los cuadros de conducción de una universidad, que tradicionalmente se realiza de manera fragmentada, p...

  18. Fomento de la convivencia en instituciones de educación superior desde la Consejería académica y de investigación.

    Directory of Open Access Journals (Sweden)

    Natalia Andrea Bernal Fonseca

    2018-01-01

    Full Text Available El presente artículo se enmarca en una investigación con enfoque mixto, desde el enfoque cualitativo con métodos de etnometodología y teoría fundamentada desde lo deductivo racionalista, nivel explicativo, con apoyo en una investigación de campo, de naturaleza cuantitativa, técnica de análisis factorial confirmatorio. El objetivo de la propuesta fue identificar factores que inciden al implementar la consejería académica y de investigación en el fomento de la convivencia, dirigida a estudiantes universitarios e identificar percepciones de docentes desde la perspectiva de la investigación. La población la constituyen 25 docentes con doctorado en el Departamento Norte de Santander y directivos de instituciones de educación superior. La entrevista, encuesta y análisis documental se utilizaron como instrumentos. Resultados: Factores económico, motivacionales, sicológicos, políticos, de carga académica, afectan la conciliación, empatía, labor investigativa y de asesoría académica de profesionales con doctorado en las universidades. Conclusión: la Consejería académica y de investigación, mejora la interacción social, convivencia, formación investigativa de la comunidad académica, brinda espacios de desarrollo de investigación de profesionales con doctorado.

  19. Structural defects and variations in the HIV-1 nef gene from rapid, slow and non-progressor children.

    Science.gov (United States)

    Casartelli, Nicoletta; Di Matteo, Gigliola; Argentini, Claudio; Cancrini, Caterina; Bernardi, Stefania; Castelli, Guido; Scarlatti, Gabriella; Plebani, Anna; Rossi, Paolo; Doria, Margherita

    2003-06-13

    Evaluation of sequence evolution as well as structural defects and mutations of the human immunodeficiency virus-type 1 (HIV-1) nef gene in relation to disease progression in infected children. We examined a large number of nef alleles sequentially derived from perinatally HIV-1-infected children with different rates of disease progression: six non-progressors (NPs), four rapid progressors (RPs), and three slow progressors (SPs). Nef alleles (182 total) were isolated from patients' peripheral blood mononuclear cells (PBMCs), sequenced and analysed for their evolutionary pattern, frequency of mutations and occurrence of amino acid variations associated with different stages of disease. The evolution rate of the nef gene apparently correlated with CD4+ decline in all progression groups. Evidence for rapid viral turnover and positive selection for changes were found only in two SPs and two RPs respectively. In NPs, a higher proportion of disrupted sequences and mutations at various functional motifs were observed. Furthermore, NP-derived Nef proteins were often changed at residues localized in the folded core domain at cytotoxic T lymphocytes (CTL) epitopes (E(105), K(106), E(110), Y(132), K(164), and R(200)), while other residues outside the core domain are more often changed in RPs (A(43)) and SPs (N(173) and Y(214)). Our results suggest a link between nef gene functions and the progression rate in HIV-1-infected children. Moreover, non-progressor-associated variations in the core domain of Nef, together with the genetic analysis, suggest that nef gene evolution is shaped by an effective immune system in these patients.

  20. Association between genetic variation in the oxytocin receptor gene and emotional withdrawal, but not between oxytocin pathway genes and diagnosis in psychotic disorders.

    Directory of Open Access Journals (Sweden)

    Marit eHaram

    2015-01-01

    Full Text Available Social dysfunction is common in patients with psychotic disorders. Oxytocin is a neuropeptide with a central role in social behaviour. This study aims to explore the relationship between oxytocin pathway genes and symptoms related to social dysfunction in patients with psychotic disorders. We performed association analyses between four oxytocin pathway genes (OXT, OXTR, AVP, CD38 and four areas of social behaviour-related psychopathology as measured by Positive and Negative Syndrome Scale (PANSS. For this purpose, we used both a polygenic risk score (PGRS and single OXTR candidate SNPs previously reported in the literature (rs53576, rs237902, rs2254298. A total of 734 subjects with DSM-IV psychotic spectrum disorders and 420 healthy controls were included. Oxytocin pathway PGRSs were calculated based on the independent Psychiatric Genomics Consortium study sample. There was a significant association between symptom of Emotional Withdrawal and the previously reported OXTR risk allele A in rs53576. No significant associations between oxytocin pathway gene variants and a diagnosis of psychotic disorder were found. Our findings indicate that while oxytocin pathway genes do not appear to contribute to the susceptibility to psychotic disorders, variations in the OXTR gene might play a role in the development of impaired social behaviour.

  1. O fordismo acadêmico na educação física

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    Eduardo Rumenig Souza

    2010-12-01

    Full Text Available Apesar da consolidação dos programas de pós-graduação stricto sensu em Educação Física (PPG-EF, críticas têm sido evidenciadas. Dentre as principais destacam-se a formação técnica e a especialização nos períodos iniciais de formação científica, a distância entre conhecimento produzido e sociedade e a valorização quantitativa da produção bibliográfica, orientando os objetivos da pesquisa para a publicação. Denominamos esse modo de produção científica de fordismo acadêmico. Assim, o objetivo do ensaio é discutir a orientação política dos PPG-EF e problematizar suas implicações para produção do conhecimento e a formação acadêmica. A ênfase na produção bibliográfica e a desvalorização da EF enquanto área de intervenção pode comprometer a formação crítica e resultar em descaracterização da área.

  2. Daily rhythm variations of the clock gene PER1 and cancer-related genes during various stages of carcinogenesis in a golden hamster model of buccal mucosa carcinoma

    Directory of Open Access Journals (Sweden)

    Ye H

    2015-06-01

    Full Text Available Hua Ye, Kai Yang, Xue-Mei Tan, Xiao-Juan Fu, Han-Xue LiDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaBackground: Recent studies have demonstrated that the clock gene PER1 regulates various tumor-related genes. Abnormal expressions and circadian rhythm alterations of PER1 are closely related to carcinogenesis. However, the dynamic circadian variations of PER1 and tumor-related genes at different stages of carcinogenesis remain unknown. This study was conducted to investigate the daily rhythm variation of PER1 and expression of tumor-related genes VEGF, KI67, C-MYC, and P53 in different stages of carcinogenesis.Materials and methods: Dimethylbenzanthracene was used to establish a golden hamster model of buccal mucosa carcinogenesis. Hamsters with normal buccal mucosa, precancerous lesion, and cancerous lesion were sacrificed at six different time points during a 24-hour period of a day. Pathological examination was conducted using routine hematoxylin and eosin staining. PER1, VEGF, KI67, C-MYC, and P53 mRNAs were detected by real-time reverse transcriptase polymerase chain reaction, and a cosinor analysis was applied to analyze the daily rhythm.Results: PER1, VEGF, C-MYC, and P53 mRNA exhibited daily rhythmic expression in three carcinogenesis stages, and KI67 mRNA exhibited daily rhythmic expression in the normal and precancerous stages. The daily rhythmic expression of KI67 was not observed in cancerous stages. The mesor and amplitude of PER1 and P53 mRNA expression decreased upon the development of cancer (P<0.05, whereas the mesor and amplitude of VEGF, KI67, and C-MYC mRNA increased upon the development of cancer (P<0.05. Compared with the normal tissues, the acrophases of PER1, VEGF, and C-MYC mRNA occurred earlier, whereas the acrophases of P53 and KI67 mRNA lagged remarkably in the precancerous lesions. In the cancer stage, the acrophases

  3. Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes

    Science.gov (United States)

    Luo, Xiongjian; Huang, Liang; Han, Leng; Luo, Zhenwu; Hu, Fang; Tieu, Roger; Gan, Lin

    2014-01-01

    Schizophrenia is a common mental disorder with high heritability and strong genetic heterogeneity. Common disease-common variants hypothesis predicts that schizophrenia is attributable in part to common genetic variants. However, recent studies have clearly demonstrated that copy number variations (CNVs) also play pivotal roles in schizophrenia susceptibility and explain a proportion of missing heritability. Though numerous CNVs have been identified, many of the regions affected by CNVs show poor overlapping among different studies, and it is not known whether the genes disrupted by CNVs contribute to the risk of schizophrenia. By using cumulative scoring, we systematically prioritized the genes affected by CNVs in schizophrenia. We identified 8 top genes that are frequently disrupted by CNVs, including NRXN1, CHRNA7, BCL9, CYFIP1, GJA8, NDE1, SNAP29, and GJA5. Integration of genes affected by CNVs with known schizophrenia susceptibility genes (from previous genetic linkage and association studies) reveals that many genes disrupted by CNVs are also associated with schizophrenia. Further protein-protein interaction (PPI) analysis indicates that protein products of genes affected by CNVs frequently interact with known schizophrenia-associated proteins. Finally, systematic integration of CNVs prioritization data with genetic association and PPI data identifies key schizophrenia candidate genes. Our results provide a global overview of genes impacted by CNVs in schizophrenia and reveal a densely interconnected molecular network of de novo CNVs in schizophrenia. Though the prioritized top genes represent promising schizophrenia risk genes, further work with different prioritization methods and independent samples is needed to confirm these findings. Nevertheless, the identified key candidate genes may have important roles in the pathogenesis of schizophrenia, and further functional characterization of these genes may provide pivotal targets for future therapeutics and

  4. Relación entre nivel académico y metas de socialización en madres de niños preescolares

    Directory of Open Access Journals (Sweden)

    Jorge Mario Jaramillo Pérez

    2016-01-01

    Full Text Available En esta investigación se analizó cómo el nivel académico de madres de niños en edad preescolar se relaciona con sus metas de socialización. Utilizando una metodología mixta se aplicaron entrevistas semiestructuradas a 172 madres de niños entre 3 y 4 años y medio de edad que viven en Bogotá y varios municipios de la zona cundiboyacense. Las entrevistas fueron sometidas a análisis de contenido de tipo categorial para calcular la frecuencia con que se mencionaron distintas metas de socialización y examinar si hubo una relación significativa entre el nivel de formación académica de las madres y su preferencia por metas de socialización asociadas a la independencia o la interdependencia. Los resultados indican que a mayor nivel académico, mayor es el énfasis en metas de socialización asociadas a la independencia.

  5. Serotonin and Early Cognitive Development: Variation in the Tryptophan Hydroxylase 2 Gene Is Associated with Visual Attention in 7-Month-Old Infants

    Science.gov (United States)

    Leppanen, Jukka M.; Peltola, Mikko J.; Puura, Kaija; Mantymaa, Mirjami; Mononen, Nina; Lehtimaki, Terho

    2011-01-01

    Background: Allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (TPH2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. Little is known about the effects of this gene…

  6. Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.

    Science.gov (United States)

    Blue, Elizabeth; Louie, Tin L; Chong, Jessica X; Hebbring, Scott J; Barnes, Kathleen C; Rafaels, Nicholas M; Knowles, Michael R; Gibson, Ronald L; Bamshad, Michael J; Emond, Mary J

    2018-04-01

    Cystic fibrosis, like primary ciliary dyskinesia, is an autosomal recessive disorder characterized by abnormal mucociliary clearance and obstructive lung disease. We hypothesized that genes underlying the development or function of cilia may modify lung disease severity in persons with cystic fibrosis. To test this hypothesis, we compared variants in 93 candidate genes in both upper and lower tertiles of lung function in a large cohort of children and adults with cystic fibrosis with those of a population control dataset. Variants within candidate genes were tested for association using the SKAT-O test, comparing cystic fibrosis cases defined by poor (n = 127) or preserved (n = 127) lung function with population controls (n = 3,269 or 3,148, respectively). Associated variants were then tested for association with related phenotypes in independent datasets. Variants in DNAH14 and DNAAF3 were associated with poor lung function in cystic fibrosis, whereas variants in DNAH14 and DNAH6 were associated with preserved lung function in cystic fibrosis. Associations between DNAH14 and lung function were replicated in disease-related phenotypes characterized by obstructive lung disease in adults. Genetic variants within DNAH6, DNAH14, and DNAAF3 are associated with variation in lung function among persons with cystic fibrosis.

  7. Polymorphic genes of major effect: consequences for variation, selection and evolution in Arabidopsis thaliana.

    Science.gov (United States)

    Stinchcombe, John R; Weinig, Cynthia; Heath, Katy D; Brock, Marcus T; Schmitt, Johanna

    2009-07-01

    The importance of genes of major effect for evolutionary trajectories within and among natural populations has long been the subject of intense debate. For example, if allelic variation at a major-effect locus fundamentally alters the structure of quantitative trait variation, then fixation of a single locus can have rapid and profound effects on the rate or direction of subsequent evolutionary change. Using an Arabidopsis thaliana RIL mapping population, we compare G-matrix structure between lines possessing different alleles at ERECTA, a locus known to affect ecologically relevant variation in plant architecture. We find that the allele present at ERECTA significantly alters G-matrix structure-in particular the genetic correlations between branch number and flowering time traits-and may also modulate the strength of natural selection on these traits. Despite these differences, however, when we extend our analysis to determine how evolution might differ depending on the ERECTA allele, we find that predicted responses to selection are similar. To compare responses to selection between allele classes, we developed a resampling strategy that incorporates uncertainty in estimates of selection that can also be used for statistical comparisons of G matrices.

  8. A combination of PhP typing and β-d-glucuronidase gene sequence variation analysis for differentiation of Escherichia coli from humans and animals.

    Science.gov (United States)

    Masters, N; Christie, M; Katouli, M; Stratton, H

    2015-06-01

    We investigated the usefulness of the β-d-glucuronidase gene variance in Escherichia coli as a microbial source tracking tool using a novel algorithm for comparison of sequences from a prescreened set of host-specific isolates using a high-resolution PhP typing method. A total of 65 common biochemical phenotypes belonging to 318 E. coli strains isolated from humans and domestic and wild animals were analysed for nucleotide variations at 10 loci along a 518 bp fragment of the 1812 bp β-d-glucuronidase gene. Neighbour-joining analysis of loci variations revealed 86 (76.8%) human isolates and 91.2% of animal isolates were correctly identified. Pairwise hierarchical clustering improved assignment; where 92 (82.1%) human and 204 (99%) animal strains were assigned to their respective cluster. Our data show that initial typing of isolates and selection of common types from different hosts prior to analysis of the β-d-glucuronidase gene sequence improves source identification. We also concluded that numerical profiling of the nucleotide variations can be used as a valuable approach to differentiate human from animal E. coli. This study signifies the usefulness of the β-d-glucuronidase gene as a marker for differentiating human faecal pollution from animal sources.

  9. Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome.

    Directory of Open Access Journals (Sweden)

    Musa Drini

    2011-02-01

    Full Text Available Hyperplastic Polyposis Syndrome (HPS is a condition associated with multiple serrated polyps, and an increased risk of colorectal cancer (CRC. At least half of CRCs arising in HPS show a CpG island methylator phenotype (CIMP, potentially linked to aberrant DNA methyltransferase (DNMT activity. CIMP is associated with methylation of tumor suppressor genes including regulators of DNA mismatch repair (such as MLH1, MGMT, and negative regulators of Wnt signaling (such as WIF1. In this study, we investigated the potential for interaction of genetic and epigenetic variation in DNMT genes, in the aetiology of HPS.We utilized high resolution melting (HRM analysis to screen 45 cases with HPS for novel sequence variants in DNMT1, DNMT3A, DNMT3B, and DNMT3L. 21 polyps from 13 patients were screened for BRAF and KRAS mutations, with assessment of promoter methylation in the DNMT1, DNMT3A, DNMT3B, DNMT3L MLH1, MGMT, and WIF1 gene promoters.No pathologic germline mutations were observed in any DNA-methyltransferase gene. However, the T allele of rs62106244 (intron 10 of DNMT1 gene was over-represented in cases with HPS (p<0.01 compared with population controls. The DNMT1, DNMT3A and DNMT3B promoters were unmethylated in all instances. Interestingly, the DNMT3L promoter showed low levels of methylation in polyps and normal colonic mucosa relative to matched disease free cells with methylation level negatively correlated to expression level in normal colonic tissue. DNMT3L promoter hypomethylation was more often found in polyps harbouring KRAS mutations (p = 0.0053. BRAF mutations were common (11 out of 21 polyps, whilst KRAS mutations were identified in 4 of 21 polyps.Genetic or epigenetic alterations in DNMT genes do not appear to be associated with HPS, but further investigation of genetic variation at rs62106244 is justified given the high frequency of the minor allele in this case series.

  10. Lateralidad y rendimiento académico, su relación.

    OpenAIRE

    Repila-Ronderos, Ana Magdalena

    2014-01-01

    La práctica profesional en el ámbito de los problemas de aprendizaje destaca la importancia del adecuado desarrollo de la lateralidad a modo de prevención de dificultades en la lectura, la escritura, la organización témporo-espacial y el desarrollo motriz, entre otras. El objetivo del trabajo fue el de establecer la relación existente entre el desarrollo de la lateralidad y el rendimiento académico. Se evaluó la lateralidad en 76 niños de 2° de Primaria con una prueba específica y se relacion...

  11. Académico Dr. Gilberto Ángel Mejia (1922- 2008.

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Salamanca Solís

    2008-06-01

    En su vida y como Académico se distinguió por la voluntad de servicio a la Academia, a la comunidad, a los colegas, al laboratorio y a la profesión médica en general, en el marco de la ética y la responsabilidad. El 30 de noviembre de 2007 la Academia de Medicina del Valle del Cauca reconoció su vida y obra al conferirle la Condecoración Medalla Saulo Muñoz Delgado en el marco del día Panamericano del Médico -Homenaje a Médicos Ilustres Vallecaucanos-

  12. Molecular variation at a candidate gene implicated in the regulation of fire ant social behavior.

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    Dietrich Gotzek

    2007-11-01

    Full Text Available The fire ant Solenopsis invicta and its close relatives display an important social polymorphism involving differences in colony queen number. Colonies are headed by either a single reproductive queen (monogyne form or multiple queens (polygyne form. This variation in social organization is associated with variation at the gene Gp-9, with monogyne colonies harboring only B-like allelic variants and polygyne colonies always containing b-like variants as well. We describe naturally occurring variation at Gp-9 in fire ants based on 185 full-length sequences, 136 of which were obtained from S. invicta collected over much of its native range. While there is little overall differentiation between most of the numerous alleles observed, a surprising amount is found in the coding regions of the gene, with such substitutions usually causing amino acid replacements. This elevated coding-region variation may result from a lack of negative selection acting to constrain amino acid replacements over much of the protein, different mutation rates or biases in coding and non-coding sequences, negative selection acting with greater strength on non-coding than coding regions, and/or positive selection acting on the protein. Formal selection analyses provide evidence that the latter force played an important role in the basal b-like lineages coincident with the emergence of polygyny. While our data set reveals considerable paraphyly and polyphyly of S. invicta sequences with respect to those of other fire ant species, the b-like alleles of the socially polymorphic species are monophyletic. An expanded analysis of colonies containing alleles of this clade confirmed the invariant link between their presence and expression of polygyny. Finally, our discovery of several unique alleles bearing various combinations of b-like and B-like codons allows us to conclude that no single b-like residue is completely predictive of polygyne behavior and, thus, potentially causally

  13. Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor ( Gene

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    Xiaoyan Zhang

    2015-10-01

    Full Text Available The AT motif-binding factor (ATBF1 not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3 (PIAS3 to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1 gene (also known as POU1F1 critically affecting mammalian growth and development. The goal of this study was to detect novel nucleotide variations and haplotypes structure of the ATBF1 gene, as well as to test their associations with growth-related traits in goats. Herein, a total of seven novel single nucleotide polymorphisms (SNPs (SNP 1-7 within this gene were found in two well-known Chinese native goat breeds. Haplotypes structure analysis demonstrated that there were four haplotypes in Hainan black goat while seventeen haplotypes in Xinong Saanen dairy goat, and both breeds only shared one haplotype (hap1. Association testing revealed that the SNP2, SNP5, SNP6, and SNP7 loci were also found to significantly associate with growth-related traits in goats, respectively. Moreover, one diplotype in Xinong Saanen dairy goats significantly linked to growth related traits. These preliminary findings not only would extend the spectrum of genetic variations of the goat ATBF1 gene, but also would contribute to implementing marker-assisted selection in genetics and breeding in goats.

  14. Prevalencia de vida de uso de cannabis y rendimiento académico en adolescentes

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    Manuel Guerrero-Martelo

    2015-01-01

    Full Text Available Objetivo: Esta investigación compara y establece las diferencias en la prevalencia de vida (consumo alguna vez en la vida y no prevalencia de vida de uso de cannabis sobre el ren-dimiento académico en adolescentes escolarizados. Método: En este estudio descriptivo de corte transversal se seleccionó una muestra proba-bilística de 156 estudiantes y fueron evaluados con una prueba ad hoc de autopercepción. Las técnicas estadísticas utilizadas fueron análisis de frecuencia, descriptivos, t- student, U de Mann Whitney y Chi2. Resultados: Los resultados señalan diferencias entre los grupos de prevalencia de uso de cannabis y no prevalencia de uso de cannabis en el número de cursos repetidos, días castigados en el último mes, la nota promedio del último mes, problemas escolares y la preocupación por estos, y dificultades para controlar el comportamiento en los últimos seis meses. No hubo diferencias en la comparación entre hombres y mujeres del grupo de pre-valencia de uso de cannabis. Se confirma que el cannabis afecta el rendimiento académico desde algunos factores específicos que afectan por igual a hombres y mujeres. Conclusión: Se concluye que entre el grupo de prevalencia de vida de uso de cannabishay más repetidores, a su vez, han repetido más cursos, han recibido más castigo en el colegio, tienen calificaciones más bajas, han tenido más problemas escolares y han estado más preocupados respecto a estos, y una mayor dificultad en controlar el comportamiento. En relación con el género no hay diferencias en las consecuencias sobre el rendimiento académico después de probar cannabis.

  15. AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS): partial gene deletions contribute to APS I.

    Science.gov (United States)

    Bøe Wolff, A S; Oftedal, B; Johansson, S; Bruland, O; Løvås, K; Meager, A; Pedersen, C; Husebye, E S; Knappskog, P M

    2008-03-01

    Autoimmune Addison's disease (AAD) is often associated with other components in autoimmune polyendocrine syndromes (APS). Whereas APS I is caused by mutations in the AIRE gene, the susceptibility genes for AAD and APS II are unclear. In the present study, we investigated whether polymorphisms or copy number variations in the AIRE gene were associated with AAD and APS II. First, nine SNPs in the AIRE gene were analyzed in 311 patients with AAD and APS II and 521 healthy controls, identifying no associated risk. Second, in a subgroup of 25 of these patients, AIRE sequencing revealed three novel polymorphisms. Finally, the AIRE copy number was determined by duplex quantitative PCR in 14 patients with APS I, 161 patients with AAD and APS II and in 39 healthy subjects. In two Scandinavian APS I patients previously reported to be homozygous for common AIRE mutations, we identified large deletions of the AIRE gene covering at least exon 2 to exon 8. We conclude that polymorphisms in the AIRE gene are not associated with AAD and APS II. We further suggest that DNA analysis of the parents of patients found to be homozygous for mutations in AIRE, always should be performed.

  16. Variations among Japanese of the factor IX gene (F9) detected by PCR-denaturing gradient gel electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Satoh, Chiyoko; Takahashi, Norio; Asakawa, Junichi; Hiyama, Keiko; Kodaira, Meiko (Radiation Effects Research Foundation, Hiroshima (Japan))

    1993-01-01

    In the course of feasibility studies to examine the efficiencies and practicalities of various techniques for screening for genetic variations, the human coagulation factor IX (F9) genes of 63 Japanese families were examined by PCR-denaturing gradient gel electrophoresis (PCR-DGGE). Four target sequences with lengths of 983-2,891 bp from the F9 genes of 126 unrelated individuals from Hiroshima and their 100 children were amplified by PCR, digested with restriction enzymes to approximately 500-bp fragments, and examined by DGGE - a total of 6,724 bp being examined per individual. GC-rich sequences (GC-clamps) of 40 bp were attached to both ends of the target sequences, as far as was feasible. Eleven types of new nucleotide substitutions were detected in the population, none of which produced RFLPs or caused hemophilia B. By examining two target sequences in a single lane, approximately 8,000 bp in a diploid individual could be examined. This approach is very effective for the detection of variations in DNA and is applicable to large-scale population studies. 46 refs., 3 figs., 1 tab.

  17. Tejiendo voces. Jóvenes universitarios opinan sobre la apropiación de Internet en la vida académica

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    Delia Crovi Druetta

    2012-03-01

    Full Text Available Artículo producto de la investigación titulada “Acceso, uso y apropiación de las Tecnologías de Información y Comunicación, TIC, en la comunidad académica de la UNAM”, realizada en el marco del Macroproyecto 1 “Tecnologías para la universidad de la información y la computación”. El estudio se centró en las computadoras e Internet, y buscó identificar las prácticas académicas cotidianas de alumnos, maestros e investigadores, al usar esos medios.Se reportan opiniones vertidas por los estudiantes, recabadas mediante ocho grupos focales, integrados por alumnos de los primeros y últimos semestres de diferentes carreras representativas de las cuatro áreas de conocimiento de la UNAM. Los resultados indican que existen diferencias por área y por semestre que cursa el alumno; mientras para los estudiantes de las áreas biológicas y de la salud, y físico-matemáticas y de las ingenierías, las TIC son recursos fundamentales en las actividades académicas y la vida en general, para los estudiantes de Ciencias Sociales son instrumentos de socialización. Los de Humanidades y artes las perciben como herramientas secundarias en el ámbito académico y de socialización. El conocimiento acerca de los recursos ofrecidos por la UNAM aumenta en la medida en que los estudiantes cursan semestres más avanzados, no sólo por una información natural, producto de la convivencia universitaria cotidiana, sino por la necesidad de realizar su trabajo de titulación.

  18. Relação entre estilos de aprendizagem e rendimento acadêmico dos estudantes do quinto ano de medicina

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    Mario Pellón

    2013-06-01

    Full Text Available OBJETIVO: O objetivo deste estudo foi determinar o(s estilo(s de aprendizagem dos estudantes do quinto ano do curso de medicina que frequentaram a disciplina de Oftalmologia e o nível de relação com o seu rendimento acadêmico. MÉTODOS: Foram aplicados questionários de estilos de aprendizagem de Kolb e Programação Neurolinguística (PNL para determinar o estilo de aprendizagem dos estudantes e estes foram relacionados com as avaliações finais obtidas. As variáveis foram analisadas através do teste r de Pearson. RESULTADOS: Foi observado que existe relação entre as variáveis estilos de aprendizagem e rendimento acadêmico (p < 0,05. Segundo o modelo de Kolb os estudantes com estilo reflexivo obtiveram melhor rendimento e de acordo com o modelo PNL, foram os estudantes com estilo visual. CONCLUSÃO: As variáveis estilos de aprendizagem a partir dos modelos de PNL e Kolb atuam independentemente do rendimento acadêmico dos estudantes do curso de medicina, indicando predomínio dos estilos visual e reflexivo.

  19. Flujos informacionales en repositorios cooperativos: consideraciones sobre algunas experiencias en instituciones académicas de América Latina

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    María Cecilia Corda

    2015-01-01

    Full Text Available Este trabajo, de tipo descriptivo exploratorio, se propone efectuar un análisis de una serie de repositorios cooperativos pertenecientes a instituciones académicas de América Latina. Hace hincapié en la importancia de la cooperación como práctica de larga data en el ámbito de las bibliotecas, muchas de las cuales se han convertido en líderes o partícipes importantes tanto en la implementación como en el desarrollo de los repositorios en sus respectivas instituciones. Se toman en consideración los flujos informacionales que los atraviesan a fin de conocer cómo se delinean y desarrollan en el marco de instituciones académicas de cierta envergadura y complejidad, a través de un análisis de documentación. Se resaltan los modelos de flujos de información detectados en dichos repositorios cooperativos y cómo estos, desde su singularidad, favorecen la visibilidad y la difusión del conocimiento académico y científico existente en formato digital.

  20. O impacto do envolvimento parental no desempenho acadêmico de crianças escolares El impacto del envolvimiento parental en el desempeño académico de niños escolares The impact of parental involvement on children's academic performance

    Directory of Open Access Journals (Sweden)

    Fabiana Cia

    2008-06-01

    Full Text Available O objetivo deste trabalho foi estudar a relação entre o envolvimento dos pais na educação dos filhos e o desempenho acadêmico destes. Participaram deste estudo 110 crianças da 4ªsérie do Ensino Fundamental. As crianças preencheram o questionário " Qualidade da interação familiar na visão dos filhos" e foram avaliadas usando-se o Teste de Desempenho Escolar - TDE. Observou-se que quanto maior a freqüência de comunicações entre ambos os pais e seus filhos e a participação de ambos os pais nas atividades escolares, culturais e de lazer dos filhos, melhor o desempenho acadêmico das crianças. Tais resultados sugerem a importância do envolvimento parental no desempenho acadêmico dos filhos e, em caso de déficits nessa área, a necessidade de programas, visando melhorar a qualidade das interações entre pais e filhos.El objetivo de este trabajo fue estudiar la relación entre el envolvimiento de los padres en la educación de los hijos y el desempeño académico de estos. Participaron de este estudio 110 niños de la 4ªserie de la Enseñanza Fundamental. Los niños rellenaron el cuestionario " Cualidad de la interacción familiar en la visión de los hijos" y fueron evaluados usándose el Teste de Desempeño Escolar - TDE. Se observó que cuanto mayor la frecuencia de comunicaciones entre ambos los padres y sus hijos y la participación de ambos los padres en las actividades escolares, culturales y de lazer de los hijos, mejor el desempeño académico de los niños. Tales resultados sugieren la importancia del envolvimiento parental en el desempeño académico de los hijos y, en caso de déficits en esa área, la necesidad de programas, visando mejorar la cualidad de las interacciones entre padres e hijos.The relationship between parental involvement in children’s education and children’s academic performance is provided. A total of 110 (fourth grade children participated in this study. The children completed the

  1. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC Risk.

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    Ganna Chornokur

    Full Text Available Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC, we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk.In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC. Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS. SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q<0.2 was applied to adjust for multiple comparisons.The most significant evidence of an association for all invasive cancers combined and for the serous subtype was observed for SNP rs17216603 in the iron transporter gene HEPH (invasive: OR = 0.85, P = 0.00026; serous: OR = 0.81, P = 0.00020; this SNP was also associated with the borderline/low malignant potential (LMP tumors (P = 0.021. Other genes significantly associated with EOC histological subtypes (p<0.05 included the UGT1A (endometrioid, SLC25A45 (mucinous, SLC39A11 (low malignant potential, and SERPINA7 (clear cell carcinoma. In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects. The most significant imputed SNP was rs117729793 in SLC39A11 (per allele, OR = 2.55, 95% CI = 1.5-4.35, p = 5.66x10-4.These results, generated on a large cohort of women, revealed associations between inherited cellular

  2. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    Science.gov (United States)

    Chornokur, Ganna; Lin, Hui-Yi; Tyrer, Jonathan P.; Lawrenson, Kate; Dennis, Joe; Amankwah, Ernest K.; Qu, Xiaotao; Tsai, Ya-Yu; Jim, Heather S. L.; Chen, Zhihua; Chen, Ann Y.; Permuth-Wey, Jennifer; Aben, Katja KH.; Anton-Culver, Hoda; Antonenkova, Natalia; Bruinsma, Fiona; Bandera, Elisa V.; Bean, Yukie T.; Beckmann, Matthias W.; Bisogna, Maria; Bjorge, Line; Bogdanova, Natalia; Brinton, Louise A.; Brooks-Wilson, Angela; Bunker, Clareann H.; Butzow, Ralf; Campbell, Ian G.; Carty, Karen; Chang-Claude, Jenny; Cook, Linda S.; Cramer, Daniel W.; Cunningham, Julie M.; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; du Bois, Andreas; Despierre, Evelyn; Dicks, Ed; Doherty, Jennifer A.; Dörk, Thilo; Dürst, Matthias; Easton, Douglas F.; Eccles, Diana M.; Edwards, Robert P.; Ekici, Arif B.; Fasching, Peter A.; Fridley, Brooke L.; Gao, Yu-Tang; Gentry-Maharaj, Aleksandra; Giles, Graham G.; Glasspool, Rosalind; Goodman, Marc T.; Gronwald, Jacek; Harrington, Patricia; Harter, Philipp; Hein, Alexander; Heitz, Florian; Hildebrandt, Michelle A. T.; Hillemanns, Peter; Hogdall, Claus K.; Hogdall, Estrid; Hosono, Satoyo; Jakubowska, Anna; Jensen, Allan; Ji, Bu-Tian; Karlan, Beth Y.; Kelemen, Linda E.; Kellar, Mellissa; Kiemeney, Lambertus A.; Krakstad, Camilla; Kjaer, Susanne K.; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D.; Lee, Alice W.; Lele, Shashi; Leminen, Arto; Lester, Jenny; Levine, Douglas A.; Liang, Dong; Lim, Boon Kiong; Lissowska, Jolanta; Lu, Karen; Lubinski, Jan; Lundvall, Lene; Massuger, Leon F. A. G.; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R.; McNeish, Iain; Menon, Usha; Milne, Roger L.; Modugno, Francesmary; Moysich, Kirsten B.; Ness, Roberta B.; Nevanlinna, Heli; Eilber, Ursula; Odunsi, Kunle; Olson, Sara H.; Orlow, Irene; Orsulic, Sandra; Weber, Rachel Palmieri; Paul, James; Pearce, Celeste L.; Pejovic, Tanja; Pelttari, Liisa M.; Pike, Malcolm C.; Poole, Elizabeth M.; Risch, Harvey A.; Rosen, Barry; Rossing, Mary Anne; Rothstein, Joseph H.; Rudolph, Anja; Runnebaum, Ingo B.; Rzepecka, Iwona K.; Salvesen, Helga B.; Schernhammer, Eva; Schwaab, Ira; Shu, Xiao-Ou; Shvetsov, Yurii B.; Siddiqui, Nadeem; Sieh, Weiva; Song, Honglin; Southey, Melissa C.; Spiewankiewicz, Beata; Sucheston, Lara; Teo, Soo-Hwang; Terry, Kathryn L.; Thompson, Pamela J.; Thomsen, Lotte; Tangen, Ingvild L.; Tworoger, Shelley S.; van Altena, Anne M.; Vierkant, Robert A.; Vergote, Ignace; Walsh, Christine S.; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S.; Wicklund, Kristine G.; Wilkens, Lynne R.; Wu, Anna H.; Wu, Xifeng; Woo, Yin-Ling; Yang, Hannah; Zheng, Wei; Ziogas, Argyrios; Hasmad, Hanis N.; Berchuck, Andrew; Iversen, Edwin S.; Schildkraut, Joellen M.; Ramus, Susan J.; Goode, Ellen L.; Monteiro, Alvaro N. A.; Gayther, Simon A.; Narod, Steven A.; Pharoah, Paul D. P.; Sellers, Thomas A.; Phelan, Catherine M.

    2015-01-01

    Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. Methods In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q<0.2 was applied to adjust for multiple comparisons. Results The most significant evidence of an association for all invasive cancers combined and for the serous subtype was observed for SNP rs17216603 in the iron transporter gene HEPH (invasive: OR = 0.85, P = 0.00026; serous: OR = 0.81, P = 0.00020); this SNP was also associated with the borderline/low malignant potential (LMP) tumors (P = 0.021). Other genes significantly associated with EOC histological subtypes (p<0.05) included the UGT1A (endometrioid), SLC25A45 (mucinous), SLC39A11 (low malignant potential), and SERPINA7 (clear cell carcinoma). In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A) were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects. The most significant imputed SNP was rs117729793 in SLC39A11 (per allele, OR = 2.55, 95% CI = 1.5-4.35, p = 5.66x10-4). Conclusion These results, generated on a large cohort of women, revealed associations

  3. Variation in the Williams syndrome GTF2I gene and anxiety proneness interactively affect prefrontal cortical response to aversive stimuli.

    Science.gov (United States)

    Jabbi, M; Chen, Q; Turner, N; Kohn, P; White, M; Kippenhan, J S; Dickinson, D; Kolachana, B; Mattay, V; Weinberger, D R; Berman, K F

    2015-08-18

    Characterizing the molecular mechanisms underlying the heritability of complex behavioral traits such as human anxiety remains a challenging endeavor for behavioral neuroscience. Copy-number variation (CNV) in the general transcription factor gene, GTF2I, located in the 7q11.23 chromosomal region that is hemideleted in Williams syndrome and duplicated in the 7q11.23 duplication syndrome (Dup7), is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7. Because of this recent preclinical and clinical identification of a genetic influence on anxiety, we examined whether sequence variation in GTF2I, specifically the single-nucleotide polymorphism rs2527367, interacts with trait and state anxiety to collectively impact neural response to anxiety-laden social stimuli. Two hundred and sixty healthy adults completed the Tridimensional Personality Questionnaire Harm Avoidance (HA) subscale, a trait measure of anxiety proneness, and underwent functional magnetic resonance imaging (fMRI) while matching aversive (fearful or angry) facial identity. We found an interaction between GTF2I allelic variations and HA that affects brain response: in individuals homozygous for the major allele, there was no correlation between HA and whole-brain response to aversive cues, whereas in heterozygotes and individuals homozygous for the minor allele, there was a positive correlation between HA sub-scores and a selective dorsolateral prefrontal cortex (DLPFC) responsivity during the processing of aversive stimuli. These results demonstrate that sequence variation in the GTF2I gene influences the relationship between trait anxiety and brain response to aversive social cues in healthy individuals, supporting a role for this neurogenetic mechanism in anxiety.

  4. Genetic variation in a DNA double strand break repair gene in saudi population: a comparative study with worldwide ethnic groups.

    Science.gov (United States)

    Areeshi, Mohammed Yahya

    2013-01-01

    DNA repair capacity is crucial in maintaining cellular functions and homeostasis. However, it can be altered based on DNA sequence variations in DNA repair genes and this may lead to the development of many diseases including malignancies. Identification of genetic polymorphisms responsible for reduced DNA repair capacity is necessary for better prevention. Homologous recombination (HR), a major double strand break repair pathway, plays a critical role in maintaining the genome stability. The present study was performed to determine the frequency of the HR gene XRCC3 Exon 7 (C18067T, rs861539) polymorphisms in Saudi Arabian population in comparison with epidemiological studies by "MEDLINE" search to equate with global populations. The variant allelic (T) frequency of XRCC3 (C>T) was found to be 39%. Our results suggest that frequency of XRCC3 (C>T) DNA repair gene exhibits distinctive patterns compared with the Saudi Arabian population and this might be attributed to ethnic variation. The present findings may help in high-risk screening of humans exposed to environmental carcinogens and cancer predisposition in different ethnic groups.

  5. Asociación entre depresión y bajo rendimiento académico en estudiantes universitarios

    Directory of Open Access Journals (Sweden)

    Cindy Franco Mejía

    2011-01-01

    Full Text Available Abstract This article describes the results of the research that established the association between depression and academic achievement in undergraduate students. The design used was the cross-sectional descriptive for which was taken a probability sample of students in a public university. Depression in recent fifteen days was determined with the Zung scale for short depression (cut-off point 22/40 and the perception of academic performance during the last month was investigated by VESPA survey question. It was estimated association by calculating the ratio of opportunity (OR, it was adjusted for other variables by logistic regression. The presence of depression was identified in 155 students and (42,2% and low or poor academic performance in 101 students (26,2%. We found a relationship statistically significant relationship between depression and fair or poor academic performance (OR = 3.1, 95% CI 1.9 - 5.0, adjusted for sex and semester (goodness of fit Hosmer-Lemeshow X2 = 1.89, df = 6, p = 0.757. We concluded there is a significant relationship between depression and fair or poor academic performance in students of a public university in Santa Marta City. Resumen El presente artículo de investigación presenta los resultados de un estudio cuyo objetivo consistió en establecer la asociación entre depresión y rendimiento académico en estudiantes de pregrado. El diseño utilizado fue el descriptivo transversal para el que se tomó una muestra probabilística de estudiantes de una universidad pública, para un total de 385 participantes. La depresión durante los últimos quince días se determinó con la escala breve de Zung para depresión (punto de corte 22/40 y la percepción de rendimiento académico durante el último mes se indagó mediante una pregunta del cuestionario VESPA. Se estimó la asociación mediante el cálculo de razón de oportunidad (OR, esta se ajustó para otras variables mediante regresión logística. Los

  6. Clinical Relevance of Gene Copy Number Variation in Metastatic Clear Cell Renal Cell Carcinoma.

    Science.gov (United States)

    Nouhaud, François-Xavier; Blanchard, France; Sesboue, Richard; Flaman, Jean-Michel; Sabourin, Jean-Christophe; Pfister, Christian; Di Fiore, Frédéric

    2018-02-23

    Gene copy number variations (CNVs) have been reported to be frequent in renal cell carcinoma (RCC), with potential prognostic value for some. However, their clinical utility, especially to guide treatment of metastatic disease remains to be established. Our objectives were to assess CNVs on a panel of selected genes and determine their clinical relevance in patients who underwent treatment of metastatic RCC. The genetic assessment was performed on frozen tissue samples of clear cell metastatic RCC using quantitative multiplex polymerase chain reaction of short fluorescent fragment method to detect CNVs on a panel of 14 genes of interest. The comparison of the electropherogram obtained from both tumor and normal renal adjacent tissue allowed for CNV identification. The clinical, biologic, and survival characteristics were assessed for their associations with the most frequent CNVs. Fifty patients with clear cell metastatic RCC were included. The CNV rate was 21.4%. The loss of CDKN2A and PLG was associated with a higher tumor stage (P relevance, especially those located on CDKN2A, PLG, and ALDOB, in a homogeneous cohort of patients with clear cell metastatic RCC. Copyright © 2018 Elsevier Inc. All rights reserved.

  7. Relación del y el rendimiento académico con la satisfacción frente a los estudios en estudiantes universitarios

    Directory of Open Access Journals (Sweden)

    Carmen Cecilia Caballero D.

    2007-06-01

    Full Text Available Los estudiantes se enfrentan cada vez más a retos y exigencias del medio que demandan una gran cantidad de recursos físicos y psicológicos de diversa índole. Muchos de ellos dejan sus estudios o disminuyen de manera considerable su rendimiento académico sin encontrar una explicación. Dos variables que han sido poco estudiadas en nuestro contexto y que pueden dar claridad a buena parte de esta situación son el burnout y la satisfacción. En esta investigación se estableció la relación del burnout, el rendimiento académico, con la satisfacción frente a los estudios en una muestra de 202 universitarios de la jornada nocturna de una universidad privada de Barranquilla, quienes respondieron el MBI-SS (Schaufeli, Martínez, Marques Pinto, Salanova, & Bakker, 2002. Los resultados indican correlaciones negativas entre agotamiento, cinismo, autoeficacia y rendimiento académico con la satisfacción frente al estudio, mientras que el vigor, dedicación y absorción se correlacionaron positivamente con esta. Por otro lado, el buen funcionamiento académico se correlaciona positivamente con las dimensiones del engagement y negativamente con el cinismo; de manera particular, ninguna de las variables se correlaciona con el agotamiento, a pesar de evidenciar cinismo y baja autoeficacia.

  8. Académico Guillermo Valencia Abdala - Académico Enrique Carvajal Arjona

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2017-04-01

    Full Text Available Fragmentos Guillermo Valencia Abdala murió en Cartagena a los 90 años de edad, su deceso ocurrió en el mes de diciembre de 2016. Valencia Abdala nació en Aracataca, Magdalena, el 26 de julio de 1926. Se le reconoció como uno de los más entrañables amigos de Gabriel García Márquez, en su niñez fue uno de los 4 compañeros de Gabo en el Colegio Montessori de Aracataca, población que hoy recibe el apodo de ‘Macondo’. Luego, sus padres se trasladaron a Santa Marta donde estudió el bachillerato en el Liceo Celedón. Por su disciplina y amor a las ciencias eligió la carrera de medicina y se graduó de la Universidad Javeriana de Bogotá. En Filadelfia, EEUU, se especializó en cirugía cardiovascular y después hizo un máster en administración hospitalaria en la Universidad de Puerto Rico. El académico correspondiente y reconocido nefrólogo Enrique Carvajal Arjona falleció en Bogotá en enero de 2017. El doctor Carvajal ingresó a la Academia en 1967 con un trabajo sobre los trasplantes renales que fue publicado ese mismo año en la Revista Médica de Bogotá. Fue fundador de la sección de Nefrología del Hospital San Juan de Dios y también se desempeñó como decano de la Facultad de Medicina de la Universidad Nacional de Colombia, donde también se desempeñó como Rector.

  9. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)

    DEFF Research Database (Denmark)

    Jim, Heather S L; Lin, Hui-Yi; Tyrer, Jonathan P

    2015-01-01

    where they regulate ovulation; circadian disruption is associated with several ovarian cancer risk factors (e.g., endometriosis). However, no studies have examined variation in germline circadian genes as predictors of ovarian cancer risk and invasiveness. The goal of the current study was to examine...... single nucleotide polymorphisms (SNPs) in circadian genes BMAL1, CRY2, CSNK1E, NPAS2, PER3, REV1 and TIMELESS and downstream transcription factors KLF10 and SENP3 as predictors of risk of epithelial ovarian cancer (EOC) and histopathologic subtypes. The study included a test set of 3,761 EOC cases and 2......,722 controls and a validation set of 44,308 samples including 18,174 (10,316 serous) cases and 26,134 controls from 43 studies participating in the Ovarian Cancer Association Consortium (OCAC). Analysis of genotype data from 36 genotyped SNPs and 4600 imputed SNPs indicated that the most significant...

  10. Relación entre práctica deportiva y rendimiento académico en alumnos de Educación Primaria

    OpenAIRE

    Valer Rupérez, Pablo

    2016-01-01

    En este trabajo se lleva a cabo una revisión bibliográfica de los principales estudios que tratan la relación entre la práctica deportiva y el rendimiento académico. El logro de un rendimiento académico óptimo en la escuela es el principal objetivo de la enseñanza actual. Por otra parte, el nivel de sedentarismo en la población ha aumentado considerablemente en los últimos años, llegando a ser considerado un problema mundial. Para solventarlo, los expertos sugieren la práctica de actividad fí...

  11. logros académicos

    Directory of Open Access Journals (Sweden)

    Analía C. Chiecher

    2014-01-01

    Full Text Available El artículo estudia las relaciones entre motivación, cognición y rendimiento académico en contextos de educación a distancia mediados tecnológicamente. Si bien las relaciones entre estas variables ya han sido analizadas en el marco de contextos presenciales, se considera pertinente una nueva consideración en el marco de contextos de aprendizaje diferentes. Participaron del estudio 83 alumnos ingresantes en Carreras de la Facultad de Ciencias Económicas (Universidad Nacional de Río Cuarto dictadas en modalidad a distancia; de ellos, 25 lograron regularizar una asignatura clave del primer año en tanto que los restantes 58 no lo consiguieron. Para la recolección de datos se utilizó un cuestionario estandarizado, cuyo objetivo apunta a evaluar perfiles motivacionales y cognitivos de los estudiantes. Los resultados mostraron mejores puntuaciones en el grupo de más alto rendimiento, con diferencias estadísticamente significativas en las escalas relativas a orientación motivacional intrínseca, valoración de las tareas, pensamiento crítico, autorregulación, manejo del tiempo y ambiente de estudio, regulación del esfuerzo y aprendizaje con pares. La discusión de resultados retoma la perspectiva situada de la motivación y cognición, enfatizando la importancia de intervenir desde el contexto con la finalidad de favorecer la motivación y el uso de estrategias por parte de estudiantes que aprenden a distancia.

  12. Análise de citações em textos acadêmicos escritos An analysis of citations in written academic texts

    Directory of Open Access Journals (Sweden)

    Tatiana S. de Macedo

    2011-01-01

    Full Text Available Este artigo apresenta um estudo de citações em escrita acadêmica na perspectiva da análise de citações e dos estudos de gêneros do discurso (Moravcsik & Murugesan, 1975; Swales, 1986, 1990, 2004; Bhatia, 2004. O estudo enfoca o uso de citações por membros expertos e membros novatos da comunidade acadêmica de Linguística e consistiu na análise e comparação de nove artigos acadêmicos e treze trabalhos finais de disciplina. Os resultados mostram que as escolhas linguísticas que orientam a escrita das citações são em grande parte compartilhadas pelos membros expertos (autores dos artigos acadêmicos e pelos novatos (alunos de curso de pós-graduação, autores dos trabalhos finais de disciplina, haja vista que ambos fazem uso de citações confirmativas, em detrimento de negativas. Todavia, membros expertos, ao contrário dos novatos, utilizam a própria voz para confrontar outros autores. As implicações deste estudo reiteram a necessidade de os Cursos de Letras terem uma abordagem de ensino e aprendizagem de escrita acadêmica baseada em gêneros do discurso visando desenvolver a consciência retórica dos alunos em relação à escrita acadêmica e, consequentemente, ao uso de citações em textos escritos, de maneira a empoderar os alunos a construir um posicionamento autoral em sua comunidade discursiva.This article reports on a study of citations in academic writing from the perspective of citation analysis and genre analysis (Moravcsik & Murugesan, 1975; Swales, 1986, 1990, 2004; Bhatia, 2004. The study focuses on the use of citations by expert and novice members of the Linguistics community and presents a comparative analysis of nine research articles and thirteen student term papers in that area. The results show that the linguistic choices that guide the writing of citations are largely shared by the expert members (authors of the research articles and the novice ones (graduate students authoring the papers in that both

  13. Caracterización de procesos cognitivos de memoria, lenguaje y pensamiento, en estudiantes con bajo y alto rendimiento académico

    OpenAIRE

    Edilberto Mejía Quintero; Hugo Escobar Melo

    2012-01-01

    Este artículo presenta la caracterización de los procesos de memoria, lenguaje y pensamiento de cuatro grupos de estudiantes con bajo, medio, alto y superior rendimiento académico, entre los años de primero y quinto de primaria, con un rango entre seis y once años de edad, de un centro educativo de Bogotá-Colombia. Se aplicaron diez sub-pruebas delWISC-IV, para describir dichos procesos. El rendimiento académico se corroboró mediante informes escolares. Los resultados se procesaron con el SPS...

  14. Qual o impacto do conhecimento de informática no desempenho acadêmico dos alunos de EaD?

    Directory of Open Access Journals (Sweden)

    Eduardo de Paula e Silva Chaves

    2013-01-01

    Full Text Available Com a globalização e a difusão da internet ganhou impulso extraordinário, nos últimos anos, a educação à distância (EAD, por meio de aulas transmitidas através de websites e atividadescumpridas pelos alunos em seus próprios computadores. O EAD vem facilitar o acesso ao ensino para as pessoas que trabalham ou possuem baixo poder aquisitivo, devido ao seu custo reduzido e a exibilidades de horários. Apesar de existir há mais de 150 anos no mundo, somente nas últimas décadas a educação à distância se tornou alvo de estudos e pesquisas acadêmicas, de forma sistematizada. Neste contexto, o objetivo desta pesquisa é avaliar o impacto do conhecimentoem informática no desempenho acadêmico dos alunos de EAD da Faculdade COC. Foi realizada uma pesquisa exploratória não probabilística na Faculdade Interativa COC – EAD, Pólo Lafaiete – Ribeirão Preto. Tal pesquisa consistiu em um questionário com 21 questões dicotômicas qualitativas, relativas ao grau de conhecimento e domínio das tecnologias de informação e ensino à distância, disponibilidade de acesso a estas tecnologias, além do sexo e desempenho acadêmico(média ponderada e nota no último módulo. Os dados foram tabulados, sendo consideradas duas variáveis principais: desempenho acadêmico, representado pela nota do último módulo; e conhecimento em informática, representado pela somatória das questões relativas a este assunto. Os dados foram analisados estatisticamente, sendo a correlação entre as duas variáveis consideradas analisada pelo teste de Correlação de Pearson. Foram analisadas as entrevistas de 54respondentes do curso de Administração (44,45% do sexo masculino e 55,55% sexo feminino. O coeficiente de correlação r=0,303 indica que há uma correlação significativa entre o desempenho acadêmico dos alunos (nota e seu conhecimento em informática, ou seja, quanto maior o domínio da informática melhores as notas obtidas por estes alunos

  15. Qual o impacto do conhecimento de informática no desempenho acadêmico dos alunos de EaD?

    Directory of Open Access Journals (Sweden)

    Eduardo de Paula e Silva Chaves

    2013-10-01

    Full Text Available Com a globalização e a difusão da internet ganhou impulso extraordinário, nos últimos anos, a educação à distância (EAD, por meio de aulas transmitidas através de websites e atividades cumpridas pelos alunos em seus próprios computadores. O EAD vem facilitar o acesso ao ensino para as pessoas que trabalham ou possuem baixo poder aquisitivo, devido ao seu custo reduzido e a flexibilidades de horários. Apesar de existir há mais de 150 anos no mundo, somente nas últimas décadas a educação à distância se tornou alvo de estudos e pesquisas acadêmicas, de forma sistematizada. Neste contexto, o objetivo desta pesquisa é avaliar o impacto do conhecimento em informática no desempenho acadêmico dos alunos de EAD da Faculdade COC. Foi realizada uma pesquisa exploratória não probabilística na Faculdade Interativa COC – EAD, Pólo Lafaiete – Ribeirão Preto. Tal pesquisa consistiu em um questionário com 21 questões dicotômicas qualitativas, relativas ao grau de conhecimento e domínio das tecnologias de informação e ensino à distância, disponibilidade de acesso a estas tecnologias, além do sexo e desempenho acadêmico (média ponderada e nota no último módulo. Os dados foram tabulados, sendo consideradas duas variáveis principais: desempenho acadêmico, representado pela nota do último módulo; e conhecimento em informática, representado pela somatória das questões relativas a este assunto Os dados foram analisados estatisticamente, sendo a correlação entre as duas variáveis consideradas analisada pelo teste de Correlação de Pearson. Foram analisadas as entrevistas de 54 respondentes do curso de Administração (44,45% do sexo masculino e 55,55% sexo feminino. O coeficiente de correlação r=0,303 indica que há uma correlação significativa entre o desempenho acadêmico dos alunos (nota e seu conhecimento em informática, ou seja, quanto maior o domínio da informática melhores as notas obtidas por estes

  16. Genetic Variation and Divergence of Genes Involved in Leaf Adaxial-abaxial Polarity Establishment in Brassica rapa

    Directory of Open Access Journals (Sweden)

    Jianli eLiang

    2016-02-01

    Full Text Available Alterations in leaf adaxial–abaxial (ad-ab polarity are one of the main factors that are responsible for leaf curvature. In Chinese cabbage, to form a leafy head, leaf incurvature is an essential prerequisite. Identifying ad-ab patterning genes and investigating its genetic variations will facilitate in elucidating the mechanism underlying leaf incurvature during head formation. In the present study we conducted comparative genomic analysis of the identification of 45 leaf ad-ab patterning genes in Brassica rapa based on 26 homologs in Arabidopsis thaliana, indicating that these genes underwent expansion and were retained after whole genome triplication (WGT. We also assessed the nucleotide diversity and selection footprints of these 45 genes in a collection of 94 Brassica rapa accessions that were composed of heading and non-heading morphotypes. Six of the 45 genes showed significant negative Tajima’s D indices and nucleotide diversity reduction in heading accessions compared to that in non-heading accessions, indicating that these underwent purifying selection. Further testing of the BrARF3.1 gene, which was one of the selection signals from a larger collection, confirmed that purifying selection did occur. Our results provide genetic evidence that ad-ab patterning genes are involved in leaf incurvature that is associated in the formation of a leafy head, as well as promote an understanding of the genetic mechanism underlying leafy head formation in Chinese cabbage.

  17. Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis

    Directory of Open Access Journals (Sweden)

    Anastasia V. Ponasenko

    2017-01-01

    Full Text Available Infective endocarditis (IE is a septic inflammation of the endocardium. Recognition of microbial patterns, cytokine and acute phase responses, hemostasis features, and alterations in plasma lipid and calcium profile all have been reported to affect pathogenesis and clinical course of IE. Having recruited 123 patients with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors, we profiled their genomic DNA for 35 functionally significant polymorphisms within the 22 selected genes involved in the abovementioned pathways, with the further genetic association analysis. We found that the G/A genotype of the rs1143634 polymorphism within the IL1B gene, the G/T genotype of the rs3212227 polymorphism within the IL12B gene, the A/G genotype of the rs1130864 polymorphism within the CRP gene, and the G allele of the rs1801197 polymorphism within the CALCR gene were associated with a decreased risk of IE whereas the T/T genotype of the rs1205 polymorphism within the CRP gene was associated with a higher risk of IE. Furthermore, heterozygous genotypes of the rs1143634 and rs3212227 polymorphisms were associated with the higher plasma levels of IL-1β and IL-12, respectively. Our results indicate that inherited variation in the cytokine, acute phase response, and calcium metabolism pathways may be linked to IE.

  18. Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis

    Science.gov (United States)

    Rutkovskaya, Natalia V.; Kondyukova, Natalia V.; Odarenko, Yuri N.; Kazachek, Yana V.; Tsepokina, Anna V.; Barbarash, Leonid S.

    2017-01-01

    Infective endocarditis (IE) is a septic inflammation of the endocardium. Recognition of microbial patterns, cytokine and acute phase responses, hemostasis features, and alterations in plasma lipid and calcium profile all have been reported to affect pathogenesis and clinical course of IE. Having recruited 123 patients with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors, we profiled their genomic DNA for 35 functionally significant polymorphisms within the 22 selected genes involved in the abovementioned pathways, with the further genetic association analysis. We found that the G/A genotype of the rs1143634 polymorphism within the IL1B gene, the G/T genotype of the rs3212227 polymorphism within the IL12B gene, the A/G genotype of the rs1130864 polymorphism within the CRP gene, and the G allele of the rs1801197 polymorphism within the CALCR gene were associated with a decreased risk of IE whereas the T/T genotype of the rs1205 polymorphism within the CRP gene was associated with a higher risk of IE. Furthermore, heterozygous genotypes of the rs1143634 and rs3212227 polymorphisms were associated with the higher plasma levels of IL-1β and IL-12, respectively. Our results indicate that inherited variation in the cytokine, acute phase response, and calcium metabolism pathways may be linked to IE. PMID:28659664

  19. cis sequence effects on gene expression

    Directory of Open Access Journals (Sweden)

    Jacobs Kevin

    2007-08-01

    Full Text Available Abstract Background Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation (genetical genomics provides insight into the role of linked sequence variation in the regulation of gene expression. We investigated the role of sequence variation in cis on gene expression (cis sequence effects in a group of genes commonly studied in cancer research in lymphoblastoid cell lines. We estimated the proportion of genes exhibiting cis sequence effects and the proportion of gene expression variation explained by cis sequence effects using three different analytical approaches, and compared our results to the literature. Results We generated gene expression profiling data at N = 697 candidate genes from N = 30 lymphoblastoid cell lines for this study and used available candidate gene resequencing data at N = 552 candidate genes to identify N = 30 candidate genes with sufficient variance in both datasets for the investigation of cis sequence effects. We used two additive models and the haplotype phylogeny scanning approach of Templeton (Tree Scanning to evaluate association between individual SNPs, all SNPs at a gene, and diplotypes, with log-transformed gene expression. SNPs and diplotypes at eight candidate genes exhibited statistically significant (p cis sequence effects in our study, respectively. Conclusion Based on analysis of our results and the extant literature, one in four genes exhibits significant cis sequence effects, and for these genes, about 30% of gene expression variation is accounted for by cis sequence variation. Despite diverse experimental approaches, the presence or absence of significant cis sequence effects is largely supported by previously published studies.

  20. Nivel socioeconómico y rendimiento académico: estudiantes resilientes

    OpenAIRE

    Olmeda García, Leire

    2016-01-01

    La pobreza es un factor que influye, como se ha indicado en numerosos estudios, en el resultado académico de los chicos y las chicas desfavorecidas, así como en su proceso de aprendizaje. Además, la falta de recursos tanto económicos como culturales interacciona con múltiples variables de distinta manera. En este estudio se analiza al estudiante resiliente a partir de los resultados obtenidos en el Programa PISA de 2009 dedicado a la lectura con la pretensión de dar respuesta a la pregunta: ¿...

  1. A excelência académica na escola pública portuguesa

    OpenAIRE

    Torres, Leonor Lima; Palhares, José Augusto; Derouet, Jean-Louis; Quaresma, Luísa; Ribeiro, Álvaro Manuel Chaves; Gouveia, Andreia; Borges, Germano José Conceição Pinto; Neto-Mendes, António; Sousa, José Eduardo Lemos; Santos, Hortense; Almeida dos Santos, Álvaro; Magalhães, Carlos; Lima, Licínio C.; Nogueira, Maria Alice; Lopes, João Teixeira

    2017-01-01

    Apesar de a excelência académica ser na atualidade um eixo central da política educativa em Portugal e na Europa, pouco se tem investigado sobre este tópico. Os resultados difundidos nesta obra procuram evidenciar quais os principais fatores que promovem percursos de excelência. A realidade educativa portuguesa tem vindo a desenvolver-se ancorada na influência desta mesma agenda, quer através da reconfiguração dos valores democráticos do sistema público de educação (igualdade, inclusão e cida...

  2. Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

    NARCIS (Netherlands)

    Jamshidi, Yalda; Nolte, Ilja M.; Dalageorgou, Chrysoula; Zheng, Dongling; Johnson, Toby; Bastiaenen, Rachel; Ruddy, Suzanne; Talbott, Daniel; Norris, Kris J.; Snieder, Harold; George, Alfred L.; Marshall, Vanessa; Shakir, Saad; Kannankeril, Prince J.; Munroe, Patricia B.; Camm, A. John; Jeffery, Steve; Roden, Dan M.; Behr, Elijah R.

    2012-01-01

    Objectives This study sought to determine whether variations in NOS1AP affect drug-induced long QT syndrome (LQTS). Background Use of antiarrhythmic drugs is limited by the high incidence of serious adverse events including QT prolongation and torsades de pointes. NOS1AP gene variants play a role in

  3. Análisis de las competencias informacionales en la comunidad académica del CICIMAR-IPN

    Directory of Open Access Journals (Sweden)

    Teresa de Jesús Barriga Ramírez

    2015-04-01

    Full Text Available Objetivo. Caracterizar la competencias informacionales de la comunidad académica y los bibliotecarios del CICIMAR-IPN. Métodos. Se aplicó una encuesta la cual fue complementada con entrevistas a los directivos y coordinadores de los programas de posgrado del centro. Resultados. Se identificaron diversas falencias en la comunidad, como: la necesidad de fomento del uso de las tecnologías de información y comunicación entre los docentes e investigadores; la difusión y reconocimiento de las normas de propiedad intelectual entre los estudiantes; y el desarrollo de competencias directivas y pedagógicas para la transmitisión de conocimientos entre los bibliotecarios. Conclusiones. Se evidencia la necesidad de crear un programa de alfabetización informacional para la comunidad académica del CICIMAR-IPN, que contribuya a la generación y transferencia de conocimientos para promover su excelencia.

  4. La producción de artículos científicos como competencia a desarrollar en las nuevas generaciones académicas en Colombia

    Directory of Open Access Journals (Sweden)

    Antonio Díaz Caballero

    2013-10-01

    Full Text Available El concepto actual de las competencias académicas, implica la importancia de saber desempeñarse en un medio y dentro de un contexto establecido para los docentes y alumnos de cada proceso académico en nuestra geografía, lo mismo que en diversidad de países1. Es notoria a nivel de las instituciones académicas en educación superior, la ausencia marcada y formal de una competencia en lecto-escritura por parte de los principales actores, lo que implica una sensación de atraso en la creación de artículos científicos, resúmenes, monografías y revisiones sistemáticas de la literatura científica en Colombia y en muchos otros países2, 3.

  5. Agotamiento emocional académico en estudiantes universitarios: ¿cuánto influyen las estrategias cognitivas de regulación emocional?

    Directory of Open Access Journals (Sweden)

    Sergio Alexis Dominguez-Lara

    2018-03-01

    Full Text Available Resumen: Objetivo: Determinar la influencia de las estrategias cognitivas de regulación emocional sobre el agotamiento emocional académico en universitarios. Materiales y métodos: Esta investigación se llevó a cabo con una muestra intencional de 219 estudiantes (149 mujeres entre 16 y 40 años. Fueron utilizadas la Escala de cansancio emocional y el Cognitive Emotional Regulation Questionnarie. Fue implementado un análisis de regresión múltiple para agotamiento emocional académico (Escala de cansancio emocional, con las estrategias del Cognitive Emotional Regulation Questionnarie como predictores. Resultados: Los predictores explican de forma conjunta una variabilidad elevada de los criterios (R2 > 50%. Las estrategias cognitivas de autoculparse, rumiación y catastrofización predicen en mayor grado el agotamiento emocional académico. Conclusiones: La influencia de las estrategias cognitivas de regulación emocional sobre el agotamiento emocional académico es significativa. Se discuten las consecuencias prácticas y las limitaciones del estudio. Abstract: Objective: Determine the influence of cognitive emotion regulation strategies on academic emotional exhaustion in university students Material and methods: A study was conducted on an intentional sample of 219 individuals (including149 women between 16 and 40 years old. The Emotional Exhaustion Scale and the Cognitive Emotion Regulation Questionnaire were used. A regression multiple regression analysis was performed on the Emotional Exhaustion Scale, with the Cognitive Emotion Regulation Questionnaire strategies as predictors. Results: In both cases, the predictors jointly explain the high variability of the criteria (R2 > 50%. The cognitive strategies of self-blaming, rumination, and catastrophising predicted academic emotional exhaustion. Conclusions: The influence of cognitive emotion regulation strategies on academic emotional exhaustion is significant. The practical

  6. Supplementary Material for: Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

    KAUST Repository

    Phelan, Jody

    2016-01-01

    Abstract Background Approximately 10 % of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies. Results To elucidate the structure of these genes, 518 genomes from a diverse international collection of clinical isolates were de novo assembled. A further 21 reference M. tuberculosis complex genomes and long read sequence data were used to validate the approach. SNP analysis revealed that variation in the majority of the 168 pe/ppe genes studied was consistent with lineage. Several recombination hotspots were identified, notably pe_pgrs3 and pe_pgrs17. Evidence of positive selection was revealed in 65 pe/ppe genes, including epitopes potentially binding to major histocompatibility complex molecules. Conclusions This, the first comprehensive study of the pe and ppe genes, provides important insight into M. tuberculosis diversity and has significant implications for vaccine development.

  7. Differential effects of ADORA2A gene variations in pre-attentive visual sensory memory subprocesses.

    Science.gov (United States)

    Beste, Christian; Stock, Ann-Kathrin; Ness, Vanessa; Epplen, Jörg T; Arning, Larissa

    2012-08-01

    The ADORA2A gene encodes the adenosine A(2A) receptor that is highly expressed in the striatum where it plays a role in modulating glutamatergic and dopaminergic transmission. Glutamatergic signaling has been suggested to play a pivotal role in cognitive functions related to the pre-attentive processing of external stimuli. Yet, the precise molecular mechanism of these processes is poorly understood. Therefore, we aimed to investigate whether ADORA2A gene variation has modulating effects on visual pre-attentive sensory memory processing. Studying two polymorphisms, rs5751876 and rs2298383, in 199 healthy control subjects who performed a partial-report paradigm, we find that ADORA2A variation is associated with differences in the efficiency of pre-attentive sensory memory sub-processes. We show that especially the initial visual availability of stimulus information is rendered more efficiently in the homozygous rare genotype groups. Processes related to the transfer of information into working memory and the duration of visual sensory (iconic) memory are compromised in the homozygous rare genotype groups. Our results show a differential genotype-dependent modulation of pre-attentive sensory memory sub-processes. Hence, we assume that this modulation may be due to differential effects of increased adenosine A(2A) receptor signaling on glutamatergic transmission and striatal medium spiny neuron (MSN) interaction. Copyright © 2011 Elsevier B.V. and ECNP. All rights reserved.

  8. Diferencias de género y aprendizaje autorregulado: el efecto del rendimiento académico previo

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    Fermín Torrano

    2017-10-01

    Full Text Available En las dos últimas décadas el aprendizaje autorregulado se ha convertido en uno de los principales focos de la investigación psicoeducativa y en uno de los ejes primordiales de la práctica docente. En este contexto el objetivo de la presente investigación es examinar la existencia de diferencias de género en la motivación académica y en el uso de estrategias de aprendizaje, y comprobar qué ocurre cuando se controla el rendimiento académico previo. La muestra estuvo compuesta por 374 alumnos de 2º curso de Educación Secundaria Obligatoria (ESO. Se emplearon las escalas motivacionales del Patterns of Adaptive Learning Scales (PALS centradas en el alumno (metas personales y contextuales, creencias de autoeficacia y estrategias self-handicapping y las escalas cognitivas del MSLQ en su versión española (CEAM II. Los resultados evidencian, en un primer momento, diferencias significativas entre chicos y chicas en todas las escalas motivacionales y de estrategias consideradas, excepto en metas aprendizaje y elaboración. Sin embargo, al controlar el efecto del rendimiento previo, se pudo constatar cómo algunas de estas diferencias desaparecían. A este respecto, se destaca la necesidad de que futuras investigaciones en este campo controlen el rendimiento académico previo, además de analizar con detenimiento los estereotipos que cada género desarrolla y el estilo o sesgo en la respuesta a los cuestionarios de autoinforme según el sexo.

  9. Conversaçiones de Música a finals del segle XVI: el cas de l’acadèmia de Joan de Borja i Castro

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    Ferran Escrivà-Llorca

    2017-06-01

    Full Text Available Resum: Aquest article s’insereix dins del conjunt d’investigacions sobre la Cort dels Habsburgs. L’estudi de les acadèmies musicals és poc conegut. A partir d’algunes investigacions sobre acadèmies literàries, l’article focalitzarà en l’acadèmia musical que Joan de Borja i Castro tenia a Madrid. En aquest sentit, si el mecenatge literari cortesà ja és un tema amb múltiples variants, l’aproximació al patrocini d’altres activitats artístiques, com el cas de la música, ho és encara més. En les següents pàgines s’aprofundirà en les diverses facetes erudites de Joan de Borja amb el fil conductor de les acadèmies, com a centre d’intel·lectualitat, de creació i promoció cultural i també personal. Per aquesta acadèmia van passar alguns dels personatges del món musical ibèric més important de l’època com Francisco Guerrero o Tomás Luis de Victoria. Aquest article pretén mostrar la importància d’aquesta acadèmia com un punt neuràlgic del mecenatge musical de les darreres dècades del segle XVI.   Paraules clau: Joan de Borja, Borja, acadèmies, Habsburgs, Música, Madrid   Abstract: This work is part of the research on The Court of Habsburg in Modern Era. The study of music academies is not quite known. From few works on literary academies, this article will focus on the music academy that of Juan de Borja i Castro hold in Madrid. In this way, if the courtly literary patronage is already an issue with multiple variants, the approach to other artistic activities, such as the music, it is even more. In the following pages, it will delve into the various aspects of erudition of Juan de Borja with the thread of the academies, as a centre of intellectual, creative and cultural promotion and personal. Some of the most important composers of the Iberian World of that time, such as Francisco Guerrero or Tomás Luis de Victoria, were involved in this academy. The article aims to show the relevance of this

  10. Gene-gene, gene-environment, gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines.

    Science.gov (United States)

    Nadeem, Amina; Mumtaz, Sadaf; Naveed, Abdul Khaliq; Aslam, Muhammad; Siddiqui, Arif; Lodhi, Ghulam Mustafa; Ahmad, Tausif

    2015-05-15

    Inflammation plays a significant role in the etiology of type 2 diabetes mellitus (T2DM). The rise in the pro-inflammatory cytokines is the essential step in glucotoxicity and lipotoxicity induced mitochondrial injury, oxidative stress and beta cell apoptosis in T2DM. Among the recognized markers are interleukin (IL)-6, IL-1, IL-10, IL-18, tissue necrosis factor-alpha (TNF-α), C-reactive protein, resistin, adiponectin, tissue plasminogen activator, fibrinogen and heptoglobins. Diabetes mellitus has firm genetic and very strong environmental influence; exhibiting a polygenic mode of inheritance. Many single nucleotide polymorphisms (SNPs) in various genes including those of pro and anti-inflammatory cytokines have been reported as a risk for T2DM. Not all the SNPs have been confirmed by unifying results in different studies and wide variations have been reported in various ethnic groups. The inter-ethnic variations can be explained by the fact that gene expression may be regulated by gene-gene, gene-environment and gene-nutrient interactions. This review highlights the impact of these interactions on determining the role of single nucleotide polymorphism of IL-6, TNF-α, resistin and adiponectin in pathogenesis of T2DM.

  11. Spatial and temporal variation in selection of genes associated with pearl millet varietal quantitative traits in situ

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    Cedric Mariac

    2016-07-01

    Full Text Available Ongoing global climate changes imply new challenges for agriculture. Whether plants and crops can adapt to such rapid changes is still a widely debated question. We previously showed adaptation in the form of earlier flowering in pearl millet at the scale of a whole country over three decades. However, this analysis did not deal with variability of year to year selection. To understand and possibly manage plant and crop adaptation, we need more knowledge of how selection acts in situ. Is selection gradual, abrupt, and does it vary in space and over time? In the present study, we tracked the evolution of allele frequency in two genes associated with pearl millet phenotypic variation in situ. We sampled 17 populations of cultivated pearl millet over a period of two years. We tracked changes in allele frequencies in these populations by genotyping more than seven thousand individuals. We demonstrate that several allele frequencies changes are compatible with selection, by correcting allele frequency changes associated with genetic drift. We found marked variation in allele frequencies from year to year, suggesting a variable selection effect in space and over time. We estimated the strength of selection associated with variations in allele frequency. Our results suggest that the polymorphism maintained at the genes we studied is partially explained by the spatial and temporal variability of selection. In response to environmental changes, traditional pearl millet varieties could rapidly adapt thanks to this available functional variability.

  12. Planificación académica y cultura organizacional en las instituciones de educación básica

    Directory of Open Access Journals (Sweden)

    Juana Ojeda

    2010-01-01

    Full Text Available En este artículo se hace un resumen de un estudio que tuvo como propósito determinar la relación entre la cultura organizacional y la planificación académica en las instituciones de educación básica. El clima organizacional estuvo evaluado a partir de los elementos, categorías y tipos que lo modifican; por su parte, la planificación académica se midió a partir de las fases, principios y pasos previstos en sus objetivos. Para alcanzar el propósito establecido, se hizo una exhaustiva revisión bibliográfica que permitió fundamentar teóricamente la investigación. La construcción teórica-referencial se hizo por medio de la revisión de antecedentes, análisis de teorías, definición de conceptos y fundamentos teóricos relacionados con la temática que se investigó. El tipo de investigación utilizada fue la descriptiva. La información se obtuvo mediante la aplicación de un cuestionario aplicado al personal docente y directivo de las instituciones de educación básica investigadas. El análisis y la interpretación de los resultados obtenidos se efectuaron de manera cuantitativa utilizando el paquete estadístico computarizado denominado SPSS versión 12.0. Se logró determinar que existe una alta relación de dependencia entre las variables clima organizacional y planificación académica, lo que puso en evidencia que la planificación académica es afectada por los elementos, categorías y tipos de clima organizacional imperantes en las instituciones básicas estudiadas.

  13. Polymorphic Variation in Double Strand Break Repair Gene in Indian Population: A Comparative Approach with Worldwide Ethnic Group Variations.

    Science.gov (United States)

    Mandal, Raju Kumar; Mittal, Rama Devi

    2018-04-01

    DNA repair capacity is essential in maintaining cellular functions and homeostasis. Identification of genetic polymorphisms responsible for reduced DNA repair capacity may allow better cancer prevention. Double strand break repair pathway plays critical roles in maintaining genome stability. Present study was conducted to determine distribution of XRCC3 Exon 7 (C18067T, rs861539) and XRCC7 Intron 8 (G6721T, rs7003908) gene polymorphisms in North Indian population and compare with different populations globally. The genotype assays were performed in 224 normal healthy individuals of similar ethnicity using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Allelic frequencies of wild type were 79% (C) in XRCC3 Exon 7 C > T and 57% (G) in XRCC7 Intron 8 (G > T) 57% (G) observed. On the other hand, the variant allele frequency were 21% (T) in XRCC3 Exon 7 C > T and 43% (T) in XRCC7 Intron 8 G > T respectively. Major differences from other ethnic populations were observed. Our results suggest that frequency in these DNA repair genes exhibit distinctive pattern in India that could be attributed to ethnicity variation. This could assist in high-risk screening of humans exposed to environmental carcinogens and cancer predisposition in different ethnic groups.

  14. Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection

    DEFF Research Database (Denmark)

    Clausen, L N; Ladelund, S; Weis, N

    2014-01-01

    We evaluated the effects of genetic variation in toll-like receptors (TLR), retinoic acid-inducible gene I (RIG-I) and their signalling pathways on spontaneous hepatitis C virus (HCV) resolution. We screened 95 single-nucleotide polymorphisms (SNPs) in 22 genes. SNPs significantly associated...... with resolution in the discovery cohort were genotyped in a validation cohort. Multivariate logistic regression adjusted for sex, hepatitis B surface antigen, HIV infection and the interleukin-28B rs12979860 SNP was performed in the combined cohort. Haplotype reconstruction and linkage disequilibrium analysis...

  15. “Resistir e Consolidar”: história e trajetória do Centro Acadêmico de Ciências do Estado CACE

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    João Lucas Ribeiro Moreira

    2016-07-01

    Full Text Available RESUMO: O presente artigo se propõe a fazer uma análise histórica da recente, porém intensa trajetória do Centro Acadêmico do curso de Ciências do Estado (CACE da Universidade Federal de Minas Gerais. Desse modo, nos propomos a uma recuperação do processo de constituição do Centro Acadêmico, bem como uma análise sistemática das gestões que atuaram no CACE desde sua fundação até o ano de 2015, sendo elas: “SuperAção”, “Movimenta”, “Praxis”, “Construção Coletiva”, “COR”, além das perspectivas para a atual gestão do CACE, a “Ubuntu”. Desse modo, o artigo revela o estreito limiar existente entre a atuação estudantil organizada na consolidação e resistência do curso de Ciências do Estado da UFMG. PALAVRAS-CHAVE: Ciências do Estado; Centro Acadêmico; Movimento Estudantil.

  16. Rendimiento académico de los alumnos de secundaria que participan en el programa de aulas digitales

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    Jeckson Enrique Loza Arenas

    2017-07-01

    Full Text Available Este estudio analiza el impacto de las aulas digitales en el rendimiento académico en alumnos de educación secundaria de una institución educativa del sector público de Colombia. La metodología, de tipo cuantitativo, empleó un enfoque cuasi-experimental con dos tratamientos: un grupo experimental y uno de control, para establecer la diferencia del rendimiento académico de los alumnos participantes en el programa de aulas digitales con respecto a alumnos que no participan en el mismo. Los instrumentos empleados en este estudio fueron la aplicación de un pre-test y un post-test, una encuesta a los alumnos que integraron las aulas digitales y una encuesta al docente participante. Los resultados muestran que los alumnos participantes en el programa observan una mejora en el rendimiento académico en aspectos como la motivación, atención y participación con respecto a los alumnos que siguen un método de enseñanza tradicional; no ocurre igual en las calificaciones obtenidas ya que no se observa una mejora significativa en comparación con los alumnos no participantes. El uso de las aulas digitales mejora la disposición de los alumnos en el desarrollo de las clases, favoreciendo el trabajo colaborativo; facilitando la comprensión de los temas y dinamizando el desarrollo de las actividades de clase.

  17. Factores determinantes del rendimiento académico universitario en el Espacio Europeo de Educación Superior

    Directory of Open Access Journals (Sweden)

    José Luis Jiménez-Caballero

    2015-10-01

    Full Text Available Se puede medir la eficiencia en una gestión mediante los resultados obtenidos, teniendo en cuenta los factores a los que se tiene acceso, que inciden de manera negativa o positiva en los mismos. En una cohorte de 572 alumnos matriculados en primer curso del Grado en Finanzas y Contabilidad, analizamos el efecto que sobre los primeros resultados académicos tienen el género, la nota de acceso y el orden de preferencia con el que accedieron. Usando técnicas clásicas del análisis estadístico multidimensional de datos, se ha procedido al análisis empírico. Los resultados concluyen que: 1 no existen diferencias significativas en los primeros resultados académicos del grado en cuanto al género; 2 la nota de acceso es un factor relevante, significativo y directo en el rendimiento académico; 3 el orden de preferencia con el que el estudiante accede en primera opción es un factor que genera notas medias más elevadas; 4 de haberse establecido una nota de acceso más elevada, las calificaciones medias de las asignaturas hubieran crecido, y aquellos alumnos que abandonaron los estudios el primer año (170 no se hubieran podido matricular, con lo que se habría conseguido una mejora en la eficiencia de los recursos monetarios y educativos utilizados.

  18. SLC26A4 gene copy number variations in Chinese patients with non-syndromic enlarged vestibular aqueduct

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    Zhao Jiandong

    2012-05-01

    Full Text Available Abstract Background Many patients with enlarged vestibular aqueduct (EVA have either only one allelic mutant of the SLC26A4 gene or lack any detectable mutation. In this study, multiplex ligation-dependent probe amplification (MLPA was used to screen for copy number variations (CNVs of SLC26A4 and to reveal the pathogenic mechanisms of non-syndromic EVA (NSEVA. Methods Between January 2003 and March 2010, 923 Chinese patients (481 males, 442 females with NSEVA were recruited. Among these, 68 patients (7.4% were found to carry only one mutant allele of SLC26A4 and 39 patients (4.2% lacked any detectable mutation in SLC26A4; these 107 patients without double mutant alleles were assigned to the patient group. Possible copy number variations in SLC26A4 were detected by SALSA MLPA. Results Using GeneMapper, no significant difference was observed between the groups, as compared with the standard probe provided in the assay. The results of the capillary electrophoresis showed no significant difference between the patients and controls. Conclusion Our results suggest that CNVs and the exon deletion in SLC26A4 are not important factors in NSEVA. However, it would be premature to conclude that CNVs have no role in EVA. Genome-wide studies to explore CNVs within non-coding regions of the SLC26A4 gene and neighboring regions are warranted, to elucidate their roles in NSEVA etiology.

  19. Monsieur Omar Fassi Fihri Secrétaire perpétuel Académie HASSAN II des Sciences et Techniques Royaume du Maroc

    CERN Document Server

    Maximilien Brice

    2010-01-01

    CERN-HI-1007135 01: M. Gouighri, Boursier de l’Académie des Sciences, Université Hassan II; J. Collot, Directeur du Laboratoire international associé; R. Heuer,\tDirecteur général du CERN;O. Fassi Fehri, Secrétaire perpétuel, Académie Hassan II des Sciences et Techniques, Maroc; S. Boutouil, Boursière du Laboratoire international associé; R. Klapisch, Fondation Partager le Savoir, Président et fondateur; G.Carnot, Président de la Fondation Carnot.

  20. Influencia del grado de somnolencia, cantidad y calidad de sueño sobre el rendimiento académico en adolescentes

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    Víctor J. Quevedo-Blasco

    2011-01-01

    Full Text Available El objetivo de este estudio fue verificar como diversas variables relacionadas con el sueño pueden influir sobre el rendimiento académico medido a través de la nota media (por asignaturas y global de un grupo de estudiantes de Educación Secundaria. Se trata de un estudio descriptivo de poblaciones mediante encuestas con muestras probabilísticas transversales. La muestra estuvo compuesta por un total de 592 estudiantes adolescentes. Las variables analizadas fueron: latencia de sueño, patrón de sueño, duración del sueño, nivel de somnolencia, eficiencia habitual del sueño, perturbaciones extrínsecas, calidad subjetiva del sueño y disfunción diurna. Para la obtención de los datos se aplicaron dos cuestionarios: a el Índice de Calidad de Sueño de Pittsburg (ICSP y b la Escala de Somnolencia de Epworth (ESE. Los resultados muestran como existen diferencias estadísticamente significativas en el rendimiento académico entre los sujetos con patrón de sueño corto y medio, obteniendo estos últimos unas medias mas elevadas. Dichas diferencias son más significativas en las asignaturas de Matemáticas (ámbito numérico y Educación Física (ámbito físicodeportivo en comparación con el ámbito socio-lingüístico. La calidad del sueño influye directamente sobre el rendimiento académico, ya que cuanto mejor se percibe esta calidad, mayor es la media académica obtenida.

  1. Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia.

    Science.gov (United States)

    Barber, Lisa M; McGrath, Helen E N; Meyer, Stefan; Will, Andrew M; Birch, Jillian M; Eden, Osborn B; Taylor, G Malcolm

    2003-04-01

    The extent to which genetic susceptibility contributes to the causation of childhood acute myeloid leukaemia (AML) is not known. The inherited bone marrow failure disorder Fanconi anaemia (FA) carries a substantially increased risk of AML, raising the possibility that constitutional variation in the FA (FANC) genes is involved in the aetiology of childhood AML. We have screened genomic DNA extracted from remission blood samples of 97 children with sporadic AML and 91 children with sporadic acute lymphoblastic leukaemia (ALL), together with 104 cord blood DNA samples from newborn children, for variations in the Fanconi anaemia group C (FANCC) gene. We found no evidence of known FANCC pathogenic mutations in children with AML, ALL or in the cord blood samples. However, we detected 12 different FANCC sequence variants, of which five were novel to this study. Among six FANCC variants leading to amino-acid substitutions, one (S26F) was present at a fourfold greater frequency in children with AML than in the cord blood samples (odds ratio: 4.09, P = 0.047; 95% confidence interval 1.08-15.54). Our results thus do not exclude the possibility that this polymorphic variant contributes to the risk of a small proportion of childhood AML.

  2. Perfiles de regulación emocional y estrés académico en estudiantes de fisioterapia

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    Ramón González Cabanach

    2017-12-01

    Se obtuvieron diferencias estadísticamente significativas entre los diferentes perfiles tanto para la percepción de estresores como para las respuestas psicofisiológicas de estrés. Los estudiantes con un perfil de alta regulación emocional percibieron en menor medida el entorno académico como amenazante y experimentaron con menor frecuencia manifestaciones psicofisiológicas de estrés. Los estudiantes con perfiles de baja regulación y baja regulación con alta atención emocional mostraron resultados similares, a excepción de las alteraciones del sueño. En conclusión, los estudiantes de fisioterapia con elevadas puntuaciones en control y aceptación de sus estados emocionales perciben las circunstancias académicas de forma más adaptativa y experimentan menores respuestas de estrés.

  3. Factores resilientes asociados al rendimiento académico en estudiantes pertenecientes a la Universidad de Sucre (Colombia

    Directory of Open Access Journals (Sweden)

    Sonia Carolina Peralta Díaz

    2006-01-01

    Full Text Available El objetivo de la investigación fue determinar si existen factores resilientes asociados al rendimiento académico en una muestra de estudiantes universitarios. Dicha muestra estuvo compuesta por 345 estudiantes, distribuidos en 2 grupos, bajo rendimiento y alto rendimiento, entre los 16 y 38 años de edad. El instrumento utilizado fue el cuestionario de resiliencia para estudiantes universitarios (cre-u. Los resultados, después de aplicar el modelo estadístico de regresión logística binaria (Oportunidad Relativa, indican que existen diferencias estadísticamente significativas de los factores resilientes entre los estudiantes con alto y bajo rendimiento académico, y este último grupo es el que se encuentra en mayor riesgo debido a que existen menos factores que se asocian a él.

  4. A Comprehensive Survey of Sequence Variation in the ABCA4 (ABCR) Gene in Stargardt Disease and Age-Related Macular Degeneration

    OpenAIRE

    Rivera, Andrea; White, Karen; Stöhr, Heidi; Steiner, Klaus; Hemmrich, Nadine; Grimm, Timo; Jurklies, Bernhard; Lorenz, Birgit; Scholl, Hendrik P. N.; Apfelstedt-Sylla, Eckhart; Weber, Bernhard H. F.

    2000-01-01

    Stargardt disease (STGD) is a common autosomal recessive maculopathy of early and young-adult onset and is caused by alterations in the gene encoding the photoreceptor-specific ATP-binding cassette (ABC) transporter (ABCA4). We have studied 144 patients with STGD and 220 unaffected individuals ascertained from the German population, to complete a comprehensive, population-specific survey of the sequence variation in the ABCA4 gene. In addition, we have assessed the proposed role for ABCA4 in ...

  5. Relación del Estrés Académico y Rendimiento Académico en estudiantes de la carrera de Administración Industrial del Servicio Nacional de Adiestramiento en Trabajo Industrial (SENATI) de la Sede Luis Cáceres Graziani Cercado de Lima, período 2015-II

    OpenAIRE

    Pando Tumpay, Angela Antonia

    2016-01-01

    El objetivo de esta investigación fue, determinar la relación que existe entre el estrés académico y el nivel de rendimiento académico en estudiantes de la carrera de Administración Industrial del SENATI Sede Luis Cáceres Graziani Cercado de Lima, período 2015-II. La muestra tomada es de 99 alumnos del segundo semestre, conformada por 51 mujeres y 48 varones, esta investigación se enmarcó dentro del nivel correlacional de Pearson (0.686) esta relación es significativa positiva...

  6. Estrategia didáctica para disminuir el estrés académico hacia el contenido estadístico en los estudiantes de medicina

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    Arnaldo Espindola Artola

    Full Text Available En la carrera de medicina se evidencia desmotivación del estudiante hacia el aprendizaje del contenido estadístico y la presencia del estrés académico que genera este contenido que se imparte en la asignatura Metodología de la Investigación y Estadística. En el trabajo se diseña una estrategia didáctica para la disminución del estrés académico en los alumnos de segundo año de la carrera de medicina. Se realizó un estudio pre-experimental, con análisis cuanti-cualitativo. La muestra estuvo conformada por los 43 estudiantes del grupo A1 y B4, a los cuales se les aplicó un inventario de estrés académico y una entrevista. Como parte del proceso de experimentación se aplicaron diferentes técnicas participativas enfocadas a la enseñanza aprendizaje del contenido estadístico. Para procesar los datos se utilizó el programa SPSS. Finalmente se pudo concluir que la aplicación de técnicas participativas contribuye a minimizar el estrés académico hacia el contenido.

  7. Relación del burnout y el rendimiento académico con la satisfacción frente a los estudios en estudiantes universitarios

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    Carmen Cecilia Caballero D.

    2010-07-01

    Full Text Available Los estudiantes se enfrentan cada vez más a retos y exigencias del medio que demandan una gran cantidad de recursos físicos y psicológicos de diversa índole. Muchos de ellos dejan sus estudios o disminuyen de manera considerable su rendimiento académico sin encontrar una explicación. Dos variables que han sido poco estudiadas en nuestro contexto y que pueden dar claridad a buena parte de esta situación son el burnout y la satisfacción. En esta investigación se estableció la relación del burnout, el rendimiento académico, con la satisfacción frente a los estudios en una muestra de 202 universitarios de la jornada nocturna de una universidad privada de Barranquilla, quienes respondieron el MBI-SS (Schaufeli, Martínez, Marques Pinto, Salanova, & Bakker, 2002. Los resultados indican correlaciones negativas entre agotamiento, cinismo, autoeficacia y rendimiento académico con la satisfacción frente al estudio, mientras que el vigor, dedicación y absorción se correlacionaron positivamente con esta. Por otro lado, el buen funcionamiento académico se correlaciona positivamente con las dimensiones del engagement y negativamente con el cinismo; de manera particular, ninguna de las variables se correlaciona con el agotamiento, a pesar de evidenciar cinismo y baja autoeficacia.

  8. Allelic diversity in an NLR gene BPH9 enables rice to combat planthopper variation.

    Science.gov (United States)

    Zhao, Yan; Huang, Jin; Wang, Zhizheng; Jing, Shengli; Wang, Yang; Ouyang, Yidan; Cai, Baodong; Xin, Xiu-Fang; Liu, Xin; Zhang, Chunxiao; Pan, Yufang; Ma, Rui; Li, Qiaofeng; Jiang, Weihua; Zeng, Ya; Shangguan, Xinxin; Wang, Huiying; Du, Bo; Zhu, Lili; Xu, Xun; Feng, Yu-Qi; He, Sheng Yang; Chen, Rongzhi; Zhang, Qifa; He, Guangcun

    2016-10-24

    Brown planthopper (BPH), Nilaparvata lugens Stål, is one of the most devastating insect pests of rice (Oryza sativa L.). Currently, 30 BPH-resistance genes have been genetically defined, most of which are clustered on specific chromosome regions. Here, we describe molecular cloning and characterization of a BPH-resistance gene, BPH9, mapped on the long arm of rice chromosome 12 (12L). BPH9 encodes a rare type of nucleotide-binding and leucine-rich repeat (NLR)-containing protein that localizes to the endomembrane system and causes a cell death phenotype. BPH9 activates salicylic acid- and jasmonic acid-signaling pathways in rice plants and confers both antixenosis and antibiosis to BPH. We further demonstrated that the eight BPH-resistance genes that are clustered on chromosome 12L, including the widely used BPH1, are allelic with each other. To honor the priority in the literature, we thus designated this locus as BPH1/9 These eight genes can be classified into four allelotypes, BPH1/9-1, -2, -7, and -9 These allelotypes confer varying levels of resistance to different biotypes of BPH. The coding region of BPH1/9 shows a high level of diversity in rice germplasm. Homologous fragments of the nucleotide-binding (NB) and leucine-rich repeat (LRR) domains exist, which might have served as a repository for generating allele diversity. Our findings reveal a rice plant strategy for modifying the genetic information to gain the upper hand in the struggle against insect herbivores. Further exploration of natural allelic variation and artificial shuffling within this gene may allow breeding to be tailored to control emerging biotypes of BPH.

  9. Ações, pensamentos, sentimentos e estratégias no processo de pesquisa acadêmica

    Directory of Open Access Journals (Sweden)

    Janaina Ferreira Fialho

    2010-12-01

    Full Text Available A pesquisa busca compreender o comportamento informacional dos estudantes vencedores do Prêmio Jovem Cientista, através de suas ações, pensamentos, sentimentos e estratégias durante a realização das pesquisas acadêmicas. Nove estudantes dos cursos de Comércio Exterior, Comunicação, Design Gráfico, Direito, Engenharia de Alimentos, Engenharia Química, Fisioterapia, Relações Internacionais e Tecnologia em Gestão da Qualidade e Produtividade foram entrevistados no ano de 2008. As categorias de análise do comportamento informacional foram a revisão de literatura, estabelecimento do foco da pesquisa, seleção e uso das fontes de informação, escrita e apresentação final do trabalho. É possível afirmar que o Modelo ISP é um referente importante para a compreensão do comportamento informacional de jovens na prática da pesquisa acadêmica. O Prêmio Jovem Cientista pode ser considerado um marco importante na vida dos estudantes vencedores em relação ao aprendizado de pesquisa, ao reconhecimento social e ao desenvolvimento da carreira profissional.

  10. Estilos de aprendizaje y rendimiento académico en estudiantes de Psicología

    Directory of Open Access Journals (Sweden)

    Gustavo Esguerra Pérez

    2010-01-01

    Full Text Available El estudio se ejecutó con la población estudiantil de la Facultad de Psicología de la Universidad Santo Tomás de Bogotá. El propósito de esta investigación es describir los estilos de aprendizaje e identificar si existe correlación entre éstos y el rendimiento académico de los estudiantes de Psicología. Los resultados evidenciaron que todos los estilos de aprendizaje se encuentran presentes en el grupo de estudiantes de Psicología de la USTA evaluados. Este grupo tiende más al estilo reflexivo. Se observó que existe relación significativa entre los modos de aprendizaje y el rendimiento académico, especialmente, en los estudiantes que muestran estilo activo y en los que expresan estilo reflexivo. Los estudiantes que conviven con la familia nuclear tienden a un mayor grado de reflexividad en comparación con quienes viven solos, esto puede mostrar que convivir en familia estaría relacionado con mantener mayor soporte social y red de apoyo para adoptar desafíos y alcanzar metas.

  11. Sequence variation in the alpha-toxin encoding plc gene of Clostridium perfringens strains isolated from diseased and healthy chickens

    DEFF Research Database (Denmark)

    Abildgaard, L; Engberg, RM; Pedersen, Karl

    2009-01-01

    The aim of the present study was to analyse the genetic diversity of the alpha-toxin encoding plc gene and the variation in a-toxin production of Clostridium perfringens type A strains isolated from presumably healthy chickens and chickens suffering from either necrotic enteritis (NE) or cholangio......-hepatitis. The a-toxin encoding plc genes from 60 different pulsed-field gel electrophoresis (PFGE) types (strains) of C perfringens were sequenced and translated in silico to amino acid sequences and the a-toxin production was investigated in batch cultures of 45 of the strains using an enzyme...

  12. Actividades extraescolares y rendimiento académico en alumnos de primaria

    Directory of Open Access Journals (Sweden)

    Ramón Cladellas Pros

    2013-08-01

    Full Text Available El objetivo de este trabajo es valorar la posible incidencia en el rendimiento académico de alumnos de primaria, de la realización -o no- de actividades extraescolares, según su tipología (recreativas, cognitivas o ambas y el número de horas de actividades realizadas. La muestra final estaba formada por un total de 721 alumnos de primaria (366 niños y 355 niñas procedentes de diversos centros escolares de las comarcas catalanas y de las Islas Baleares. Se facilitó a los padres de los alumnos un cuestionario en el que debían indicar las notas obtenidas en diferentes materias (matemáticas, catalán, castellano, idiomas, gimnasia y plástica y responder datos relacionados con la realización de actividades extraescolares. Los resultados muestran cómo la realización de algún tipo de actividad extraescolar, sea del tipo que sea, mejora el rendimiento académico de los niños y niñas de la muestra. La sola realización de algún tipo de actividad (ya sea recreativa o cognitiva, o una combinación de ambas, incide positivamente y significativamente en los resultados obtenidos en todas las materias estudiadas, a excepción de las asignaturas de matemáticas, gimnasia y plástica. Asimismo, un número elevado de horas de actividades extraescolares (más de 10 horas y media a la semana afecta negativamente a los resultados obtenidos en todas las materias menos en gimnasia.

  13. Aprendizaje autorregulado en el nivel universitario: Un estudio situado con estudiantes de psicopedagogía de diferentes ciclos académicos

    Directory of Open Access Journals (Sweden)

    Ana Clara Ventura

    2017-04-01

    Full Text Available Ser capaz de autorregular adecuadamente el propio aprendizaje impacta positivamente en el rendimiento académico del alumnado. De aquí la relevancia de entender cuáles son, cómo se articulan y cómo cambian estrategias de aprendizaje y patrones de motivación en el transcurso de la formación académica. Los objetivos de este trabajo son: (a describir estrategias cognitivas/metacognitivas de aprendizaje y patrones de motivación usadas por estudiantes (media y desviación estándar; (b analizar las correlaciones entre ambos grupos de variables (correlación índice de Pearson; (c contrastar resultados según Ciclo Básico (1° año y Superior (5° año de formación académica (prueba de hipótesis t de Student. El estudio cuantitativo ex post facto se basó en la administración de la versión argentina del MSLQ (Motivated Strategies Learning Questionnaire denominada MSLQe a 114 estudiantes de psicopedagogía. Los resultados muestran: (a un repertorio variado de estrategias y patrones de motivación para el aprendizaje; (b un mayor uso de estrategias metacognitivas de autorregulación y estrategias de manejo del tiempo y ambiente de estudio se asoció a altos niveles en los patrones motivacionales de orientación a metas, valoración de la tarea, creencias de control y de autoeficacia del estudiantado; (c diferencias significativas según el ciclo académico: a favor del alumnado principiante en estrategias cognitivas de repaso, autorregulación metacognitiva y organización; mientras que las puntuaciones fueron superiores para los alumnos y las alumnas avanzadas en relación a pensamiento crítico. Asimismo, respecto de los patrones de motivación, los grupos avanzados declararon mayores tendencias hacia metas de orientación intrínsecas, mientras que los principiantes lo hicieron en metas de motivación extrínsecas, creencias de control, de autoeficacia y ansiedad. Es posible concluir que la formación académica posibilitó una

  14. Análisis multinivel de los factores asociados al rendimiento académico en el Instituto Tecnológico de Costa Rica

    OpenAIRE

    Moreira-Mora, Tania Elena

    2011-01-01

    5402-1580-0601 El rendimiento académico y la deserción de los estudiantes ha sido una preocupación constante de las autoridades y equipos docentes de las distintas escuelas del Instituto Tecnológico de Costa Rica. Por ello, el área temática de esta investigación se engloba en los factores de contexto, entrada y procesos asociados con el rendimiento académico en Matemática General de los estudiantes que ingresaron en el 2010 a esta institución.

  15. Influencia de las estrategias de aprendizaje en el rendimiento académico de los estudiantes ingresantes de la Universidad Nacional Jorge Basadre Grohmann

    OpenAIRE

    Mamani Callacondo, Angel Cristóbal

    2011-01-01

    El objetivo del estudio ha sido determinar la influencia de las estrategias de aprendizaje en el rendimiento académico de los ingresantes a la Universidad Nacional Jorge Basadre Grohmann - 2007, así como analizar diferencias de estrategias de aprendizaje y rendimiento académico según el género. El trabajo se ha realizado con una muestra de 283 universitarios de ambos sexos de diferentes carreras profesionales que cumplieron de forma voluntaria el Inventario de Habilidades y Estrategias...

  16. El uso académico de las redes sociales en universitarios The Academic Use of Social Networks among University Students

    Directory of Open Access Journals (Sweden)

    Pedro Farias Batlle

    2012-03-01

    Full Text Available El uso académico que hacen los universitarios de las redes sociales es el estudio que se presenta a partir de una encuesta administrada a una muestra representativa de estudiantes de la Universidad de Málaga (n=938 y dos grupos de discusión. Dado que el consumo de redes se ha implantado profundamente en las rutinas diarias de los estudiantes, las vastas posibilidades comunicativas de estos canales podrían considerarse para sacar provecho educativo en el futuro, a pesar del predominio del uso dirigido al entretenimiento. Se discuten cuáles son las redes más adecuadas para su uso académico, qué tipo de actividades pueden tener mejor acogida entre los estudiantes y qué herramientas de las redes sociales podrían ser más útiles para propósitos académicos. Los resultados indican que el consumo de redes sociales de la población estudiada es muy alto. Así mismo, los estudiantes presentan una actitud favorable a que los docentes utilicen las redes como recurso educativo. Sin embargo, la frecuencia con la que los estudiantes dan un uso académico a las redes es más bien escasa y, en promedio, las actividades académicas con frecuencia de uso más elevada son aquellas que parten de la iniciativa de los propios estudiantes, como la solución de dudas inter pares o la realización de trabajos de clase. Del escaso apoyo académico percibido en las redes por los estudiantes, se deduce un limitado aprovechamiento por parte de los docentes.This paper examines the academic use made of the social networks by university students through a survey conducted among a representative sample of students at Universidad de Málaga (Spain (n=938 and two discussion groups. Given that network consumption has profoundly penetrated the daily routines of the students, the vast communication possibilities of these channels could be considered for educational use in the future despite a predominance of entertainment-related use. We discuss the most suitable

  17. A biossegurança e segurança do paciente na visão de acadêmicos de enfermagem La bioseguridad y seguridad del paciente bajo la visión de académicos de enfermería Nursing students' point of view on biosecurity and patient safety

    Directory of Open Access Journals (Sweden)

    Telma Elisa Cararro

    2012-09-01

    Full Text Available Este estudo objetiva identificar o conhecimento dos acadêmicos de enfermagem frente à temática de segurança do paciente e as relações deste com o ensino da biossegurança. Estudo qualitativo, exploratório, realizado na Universidade Federal de Santa Catarina, com 17 acadêmicos da terceira fase do Curso de Graduação em Enfermagem. Três categorias emergiram após leitura exaustiva das respostas: o cuidado de si e o cuidado do outro; biossegurança e o cuidado com o meio ambiente; biossegurança: educação em saúde e educação permanente no serviço de saúde. Identificou-se a preocupação dos acadêmicos na prevenção de riscos e a relação da biossegurança com o meio ambiente. Apontam o cuidado e o autocuidado como prerrogativas para a segurança do paciente e a educação como proposta para minimizar os riscos. Consideram importante o estudo da biossegurança na graduação, minimizando danos e erros nas condutas.Estudio cualitativo exploratorio, realizado en la Universidad Federal de Santa Catarina, con 17 académicos de la tercera fase del Curso de Grado en Enfermería. Objetiva identificar los conocimientos de los académicos frente a la temática de seguridad del paciente y las relaciones con la enseñanza de la bioseguridad. Surgieron tres categorías: el cuidado de sí mismo y el cuidado del otro; bioseguridad y el cuidado con el medio ambiente; bioseguridad: educación en salud y educación permanente en el servicio de salud. Se ha identificado la preocupación de los académicos en la prevención de riesgos y ellos relacionan la bioseguridad con el medio ambiente; apuntan el cuidado y el autocuidado como prerrogativas para la seguridad del paciente y a la educación como propuesta para minimizar los riesgos. Los académicos consideran importante el estudio de la bioseguridad en el grado, minimizando daños y errores en las conductas.This study is aimed at identifying the knowledge of nursing students about the subject

  18. Académie des télécentres de l'Inde | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    appuyer le renforcement des capacités des exploitants de télécentres, dont le nombre devrait atteindre un million d'ici 2010. Les partenaires nationaux de telecentre.org ont participé à la mise sur pied de l'Académie telecentre.org, à laquelle ...

  19. Cómo organizar y presentar trabajos académicos : Citas y referencias.

    OpenAIRE

    Arias Serrano, Laura

    2017-01-01

    La presente guía, fruto de mi propia labor como investigadora y tutora de numerosos trabajos, y dirigida fundamentalmente al público universitario, tiene como objetivo orientar tanto a profesores como alumnos a la hora de estructurar o redactar cualquier trabajo académico o de investigación. Dada la gran variedad de estilos y recomendaciones que actualmente existen, he optado por ofrecer al lector una serie de pautas generales, basadas en la NORMA ISO 690 [capítulo 3], que, como marco int...

  20. Variables que inciden en el rendimiento académico de adolescentes mexicanos

    OpenAIRE

    Joaquín Caso-Niebla; Laura Hernández-Guzmán

    2007-01-01

    El propósito del presente estudio fue explorar en qué medida algunas variables personales predicen el rendimiento académico de estudiantes de bachillerato. Participaron 1581 estudiantes de una institución pública de educación media superior en la Ciudad de México, con edades que fluctuaban entre los 15 y los 23 años, quienes respondieron a instrumentos de autoinforme sobre autoestima, asertividad, escolar, establecimiento de metas, actividades de estudio y consumo de sustancias. Un análisis d...

  1. Genetic Variation and Population Structure in Jamunapari Goats Using Microsatellites, Mitochondrial DNA, and Milk Protein Genes

    Science.gov (United States)

    Rout, P. K.; Thangraj, K.; Mandal, A.; Roy, R.

    2012-01-01

    Jamunapari, a dairy goat breed of India, has been gradually declining in numbers in its home tract over the years. We have analysed genetic variation and population history in Jamunapari goats based on 17 microsatellite loci, 2 milk protein loci, mitochondrial hypervariable region I (HVRI) sequencing, and three Y-chromosomal gene sequencing. We used the mitochondrial DNA (mtDNA) mismatch distribution, microsatellite data, and bottleneck tests to infer the population history and demography. The mean number of alleles per locus was 9.0 indicating that the allelic variation was high in all the loci and the mean heterozygosity was 0.769 at nuclear loci. Although the population size is smaller than 8,000 individuals, the amount of variability both in terms of allelic richness and gene diversity was high in all the microsatellite loci except ILST 005. The gene diversity and effective number of alleles at milk protein loci were higher than the 10 other Indian goat breeds that they were compared to. Mismatch analysis was carried out and the analysis revealed that the population curve was unimodal indicating the expansion of population. The genetic diversity of Y-chromosome genes was low in the present study. The observed mean M ratio in the population was above the critical significance value (Mc) and close to one indicating that it has maintained a slowly changing population size. The mode-shift test did not detect any distortion of allele frequency and the heterozygosity excess method showed that there was no significant departure from mutation-drift equilibrium detected in the population. However, the effects of genetic bottlenecks were observed in some loci due to decreased heterozygosity and lower level of M ratio. There were two observed genetic subdivisions in the population supporting the observations of farmers in different areas. This base line information on genetic diversity, bottleneck analysis, and mismatch analysis was obtained to assist the conservation

  2. Coevolutionary genetic variation in the legume-rhizobium transcriptome.

    Science.gov (United States)

    Heath, Katy D; Burke, Patricia V; Stinchcombe, John R

    2012-10-01

    Coevolutionary change requires reciprocal selection between interacting species, where the partner genotypes that are favoured in one species depend on the genetic composition of the interacting species. Coevolutionary genetic variation is manifested as genotype × genotype (G × G) interactions for fitness in interspecific interactions. Although quantitative genetic approaches have revealed abundant evidence for G × G interactions in symbioses, the molecular basis of this variation remains unclear. Here we study the molecular basis of G × G interactions in a model legume-rhizobium mutualism using gene expression microarrays. We find that, like quantitative traits such as fitness, variation in the symbiotic transcriptome may be partitioned into additive and interactive genetic components. Our results suggest that plant genetic variation had the largest influence on nodule gene expression and that plant genotype and the plant genotype × rhizobium genotype interaction determine global shifts in rhizobium gene expression that in turn feedback to influence plant fitness benefits. Moreover, the transcriptomic variation we uncover implicates regulatory changes in both species as drivers of symbiotic gene expression variation. Our study is the first to partition genetic variation in a symbiotic transcriptome and illuminates potential molecular routes of coevolutionary change. © 2012 Blackwell Publishing Ltd.

  3. Envolvimento emocional do acadêmico de enfermagem com o paciente reflexos dessa experiência na vida futura do profissional

    Directory of Open Access Journals (Sweden)

    Rita dos Santos

    1986-03-01

    Full Text Available O presente estudo aborda o envolvimento emocional do acadêmico de enfermagem com o paciente, e seus reflexos na sua vida futura como profissional. Os autores, a partir de suas observações e experiências no ensino clínico do Curso de Graduação em Enfermagem e Obstetrícia, discutem a diferença entre o relacionamento do profissional e do acadêmico de enfermagem com o paciente, analisando também a influência que este exerce em sua recuperação. Inclui reflexões sobre os prejuízos que o desconhecimento dos limites deste relacionamento acarreta para ambos e alguns recursos utilizados para a superação de conflitos.

  4. Invisibilidad y desigualdad. La política académica y las mujeres docentes en la Universidad

    Directory of Open Access Journals (Sweden)

    Yolanda López Figueroa

    2016-06-01

    Full Text Available Se analiza la poca representatividad de las mujeres en la academia  y las desigualdades que enfrentan para obtener ascensos, mejoras salariales y ascender a puestos altos de poder en las instituciones de enseñanza superior. Contrastan estos hechos con la proliferación de estudios de género en las universidades y la feminización  del estudiantado universitario. Se presentan los factores causales más importantes de la política académica como: la cultura laboral universitaria, las estructuras académicas, la doble jornada laboral, los prejuicios y los estilos de administración. Concluye que las universidades no podrán constituirse en agente de cambio social si no modifican sus políticas y estructuras de poder patriarcal que condenan a las docentes a la desigualdad. Concluye proponiendo alternativas para solucionar la problemática.

  5. Aproximación al autoconcepto y rendimiento académico en adolescentes de la provincia de Cádiz. Diferencias sexuales y repercusiones del divorcio.

    OpenAIRE

    Hinojosa Aguayo, Irene

    2015-01-01

    El objetivo del trabajo fue examinar la influencia ejercida por las variables predictoras -conflictividad interparental, nivel de ansiedad estado y rasgos de personalidad (amabilidad, conciencia, apertura, extraversión e inestabilidad emocional)- sobre las variables criterio seleccionadas -rendimiento académico y las cinco dimensiones de autoestima (académica, social, emocional, familiar y física)–, entendiendo, a su vez, el sexo y el hecho de ser hijo de padres divorciados o no, como posible...

  6. [Investigation into the relationship between mitochondrial 12 S rRNA gene, tRNA gene and cytochrome oxidase Ⅱ gene variations and the risk of noise-induced hearing loss].

    Science.gov (United States)

    Jiao, J; Gu, G Z; Chen, G S; Li, Y H; Zhang, H L; Yang, Q Y; Xu, X R; Zhou, W H; Wu, H; He, L H; Zheng, Y X; Yu, S F

    2017-01-06

    Objective: To explore the relationship between mitochondrial 12 S rRNA gene variation, tRNA gene variation and cytochrome oxidase Ⅱ gene point mutations and the risk of noise-induced hearing loss (NIHL). Methods: A nested case-control study was performed that followed a cohort of 7 445 noise-exposed workers in a steel factory in Henan province, China, from January 1, 2006 to December 31, 2015. Subjects whose average hearing threshold was more than 40 dB(A) in high frequency were defined as the case group, and subjects whose average hearing threshold was less than 35 dB(A) in high frequency and less than 25 dB (A) in speech frequency were defined as the control group. Subjects was recruited into the case group ( n =286) and the control group ( n= 286) according to gender, age, job category and time of exposure to noise, and a 1∶1 case-control study was carried out. We genotyped eight single nucleotide polymorphisms in the mitochondrial 12 S rRNA gene, the mitochondrial tRNA gene and the mitochondrial cytochrome oxidase Ⅱ gene using SNPscan high-throughput genotyping technology from the recruited subjects. The relationship between polymorphic sites and NIHL, adjusted for covariates, was analyzed using conditional logistic regression analysis, as were the subgroup data. Results: The average age of the recruited subjects was (40.3±8.1) years and the length of service exposure to noise was (18.6±8.9) years. The range of noise exposed levels and cumulative noise exposure (CNE) was 80.1- 93.4 dB (A) and 86.8- 107.9 dB (A) · year, respectively. For workers exposed to noise at a CNE level<98 dB (A) · year, smokers showed an increased risk of NIHL of 1.88 (1.16-3.05) compared with non-smokers; for workers exposed to noise at a CNE level ≥98 dB(A) · year, smokers showed an increased risk of NIHL of 2.53 (1.49- 4.30) compared with non-smokers. For workers exposed to noise at a CNE level<98 dB (A) · year, the results of univariate analysis and multifactor analysis

  7. Relaciones entre competencias, inteligencia y rendimiento académico en alumnos de Grado en Ciencias de la Actividad Física y el Deporte

    OpenAIRE

    López Varas, Francisco

    2015-01-01

    Tesis inédita presentada en la Universidad Europea de Madrid. Facultad de Ciencias de la Actividad Física y el Deporte. Programa de Doctorado en Actividad Física y Deporte El objetivo del presente estudio fue determinar la relación entre la inteligencia, competencias académicas y rendimiento académico en estudiantes universitarios del Grado en Ciencias de la Actividad Física y el Deporte. Estas relaciones también se analizaron en un estudio longitudinal con parte de la muestra total. M...

  8. ¿Cómo cambian los niveles de extensibilidad isquiosural de los estudiantes durante un año académico? Un estudio longitudinal

    OpenAIRE

    Carlos A. Becerra-Fernández; Daniel Mayorga-Vega; Rafael Merino-Marban

    2017-01-01

    El objetivo principal del presente estudio fue examinar los niveles de extensibilidad isquiosural de los estudiantes durante un curso académico. Una muestra de 128 estudiantes de 1º de bachillerato de un centro de educación secundaria se evaluó mediante la prueba de classic sit-and-reach al comienzo, mediados y final del curso académico. Los resultados mostraron que el nivel de extensibilidad de isquiosural de los estudiantes disminuyó estadísticamente significativamente desde el comienzo (22...

  9. Saberes agrícolas tradicionales como programa académico

    Directory of Open Access Journals (Sweden)

    J. Antonio Gómez Espinoza

    2008-01-01

    Full Text Available En el marco de las crisis social y ambiental del tercer milenio, se hace necesario repensar la universidad, sus paradigmas, el concepto de educación y su modelo educativo para impactar en la construcción de la nueva sociedad. Los Saberes Agrícolas Tradicionales (SAT aportan elementos conceptuales básicos para la implementación y desarrollo de una sociedad sustentable. A partir del rescate, la sistematización de los SAT y el diálogo intercultural SAT-ciencia, se propone incorporar los Saberes Agrícolas Tradicionales como programa académico en las Instituciones de Enseñanza y Aprendizaje Agrícola del nivel Superior (IEAS.

  10. El estudio académico de lo esotérico

    Directory of Open Access Journals (Sweden)

    José Ricardo Chaves Pacheco

    2015-01-01

    Full Text Available Este artículo se divide en dos partes. Primero, analiza el desarrollo lingüístico e histórico de los conceptos esotérico y esoterismo, proceso que evolucionó a una incipiente “conciencia histórica” entre los propios esoteristas, influenciada por el influjo historicista romántico, que conformó un nuevo tipo de esoterismo en tiempos de ciencia, democracia y modernidad. Y segundo, explica el proceso de transformación disciplinaria de los estudios de lo esotérico, el esoterismo y la esoterología hasta la imposición de la categoría académica de los “estudios de esoterismo occidental”.

  11. Robust assignment of cancer subtypes from expression data using a uni-variate gene expression average as classifier

    International Nuclear Information System (INIS)

    Lauss, Martin; Frigyesi, Attila; Ryden, Tobias; Höglund, Mattias

    2010-01-01

    Genome wide gene expression data is a rich source for the identification of gene signatures suitable for clinical purposes and a number of statistical algorithms have been described for both identification and evaluation of such signatures. Some employed algorithms are fairly complex and hence sensitive to over-fitting whereas others are more simple and straight forward. Here we present a new type of simple algorithm based on ROC analysis and the use of metagenes that we believe will be a good complement to existing algorithms. The basis for the proposed approach is the use of metagenes, instead of collections of individual genes, and a feature selection using AUC values obtained by ROC analysis. Each gene in a data set is assigned an AUC value relative to the tumor class under investigation and the genes are ranked according to these values. Metagenes are then formed by calculating the mean expression level for an increasing number of ranked genes, and the metagene expression value that optimally discriminates tumor classes in the training set is used for classification of new samples. The performance of the metagene is then evaluated using LOOCV and balanced accuracies. We show that the simple uni-variate gene expression average algorithm performs as well as several alternative algorithms such as discriminant analysis and the more complex approaches such as SVM and neural networks. The R package rocc is freely available at http://cran.r-project.org/web/packages/rocc/index.html

  12. Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle.

    Science.gov (United States)

    Zhang, Gui-Min; Zheng, Li; He, Hua; Song, Cheng-Chuang; Zhang, Zi-Jing; Cao, Xiu-Kai; Lei, Chu-Zhao; Lan, Xian-Yong; Qi, Xing-Lei; Chen, Hong; Huang, Yong-Zhen

    2018-03-20

    Copy number variations (CNVs) recently have been recognized as another important genetic variability followed single nucleotide polymorphisms (SNPs). The guanylate binding protein 2 (GBP2) gene plays an important role in cell proliferation. This study was performed to determine the presence of GBP2 CNV (relative to Angus cattle) in 466 individuals representing six main cattle breeds from China, identify its relationship with growth, and explore the biological effects of gene expression. There were two CNV regions in the GBP2 gene, for three types, CNV1 loss type (relative to Angus cattle) was more frequent in XN than other breeds, and CNV2 loss type (relative to Angus cattle) was more frequent in XN and CDM than other breeds. Though the GBP2 gene copy number presented no correlation with the transcriptional expression of JX (P > .05), but the transcriptional expression in heart is higher than other tissues, and the copy number in muscles and fat of JX is higher than others breeds. Statistical analysis revealed that the GBP2 gene CNV1 and CNV2 were significantly associated with growth traits (P cattle breeds, and our results suggested that the CNVs in GBP2 gene may be considered markers for the molecular breeding of Chinese beef cattle. Copyright © 2018. Published by Elsevier B.V.

  13. Genetic Variation in Cardiomyopathy and Cardiovascular Disorders.

    Science.gov (United States)

    McNally, Elizabeth M; Puckelwartz, Megan J

    2015-01-01

    With the wider deployment of massively-parallel, next-generation sequencing, it is now possible to survey human genome data for research and clinical purposes. The reduced cost of producing short-read sequencing has now shifted the burden to data analysis. Analysis of genome sequencing remains challenged by the complexity of the human genome, including redundancy and the repetitive nature of genome elements and the large amount of variation in individual genomes. Public databases of human genome sequences greatly facilitate interpretation of common and rare genetic variation, although linking database sequence information to detailed clinical information is limited by privacy and practical issues. Genetic variation is a rich source of knowledge for cardiovascular disease because many, if not all, cardiovascular disorders are highly heritable. The role of rare genetic variation in predicting risk and complications of cardiovascular diseases has been well established for hypertrophic and dilated cardiomyopathy, where the number of genes that are linked to these disorders is growing. Bolstered by family data, where genetic variants segregate with disease, rare variation can be linked to specific genetic variation that offers profound diagnostic information. Understanding genetic variation in cardiomyopathy is likely to help stratify forms of heart failure and guide therapy. Ultimately, genetic variation may be amenable to gene correction and gene editing strategies.

  14. A biossegurança e segurança do paciente na visão de acadêmicos de enfermagem La bioseguridad y seguridad del paciente bajo la visión de académicos de enfermería Nursing students' point of view on biosecurity and patient safety

    OpenAIRE

    Telma Elisa Cararro; Francine Lima Gelbcke; Luciara Fabiane Sebold; Silvana Silveira Kempfer; Maria Christina Zapelini; Roberta Waterkemper

    2012-01-01

    Este estudo objetiva identificar o conhecimento dos acadêmicos de enfermagem frente à temática de segurança do paciente e as relações deste com o ensino da biossegurança. Estudo qualitativo, exploratório, realizado na Universidade Federal de Santa Catarina, com 17 acadêmicos da terceira fase do Curso de Graduação em Enfermagem. Três categorias emergiram após leitura exaustiva das respostas: o cuidado de si e o cuidado do outro; biossegurança e o cuidado com o meio ambiente; biossegurança: edu...

  15. Un estudio cualitativo sobre los diferenciales de género en la educación superior: percepciones de las académicas en contextos masculinizados

    Directory of Open Access Journals (Sweden)

    Inés Lozano Cabezas

    2016-06-01

    Full Text Available El contexto universitario refleja, al igual que la sociedad en general, la falta de equidad y equilibrio en la representación de mujeres y hombres. En la academia aún encontramos una alta presencia de hombres, especialmente, en lo que respecta a las cátedras universitarias. En este estudio presentamos y analizamos resultados de un proyecto de investigación desarrollado en la Universidad de Alicante (España. Del análisis realizado en los siete centros o unidades académicas de esta universidad, en el que aún las académicas conviven en contextos masculinizados, emergen las diferencias de oportunidades percibidas por las profesoras universitarias en su desarrollo profesional docente e investigador, aunque muchas de ellas no las relacionan con la discriminación por género. Cuando las académicas se han encontrado en situaciones discriminatorias manifiestan una actitud activa y reivindicativa, excepto en los centros altamente masculinizados donde mantienen una actitud pasiva para que el ambiente de trabajo sea óptimo. Consideramos que es necesario continuar indagando en estos espacios donde la presencia de las académicas sigue siendo minoritaria a pesar de las reformas universitarias en materia de igualdad desarrolladas en la Educación Superior.

  16. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

    Science.gov (United States)

    Elia, Josephine; Glessner, Joseph T; Wang, Kai; Takahashi, Nagahide; Shtir, Corina J; Hadley, Dexter; Sleiman, Patrick M A; Zhang, Haitao; Kim, Cecilia E; Robison, Reid; Lyon, Gholson J; Flory, James H; Bradfield, Jonathan P; Imielinski, Marcin; Hou, Cuiping; Frackelton, Edward C; Chiavacci, Rosetta M; Sakurai, Takeshi; Rabin, Cara; Middleton, Frank A; Thomas, Kelly A; Garris, Maria; Mentch, Frank; Freitag, Christine M; Steinhausen, Hans-Christoph; Todorov, Alexandre A; Reif, Andreas; Rothenberger, Aribert; Franke, Barbara; Mick, Eric O; Roeyers, Herbert; Buitelaar, Jan; Lesch, Klaus-Peter; Banaschewski, Tobias; Ebstein, Richard P; Mulas, Fernando; Oades, Robert D; Sergeant, Joseph; Sonuga-Barke, Edmund; Renner, Tobias J; Romanos, Marcel; Romanos, Jasmin; Warnke, Andreas; Walitza, Susanne; Meyer, Jobst; Pálmason, Haukur; Seitz, Christiane; Loo, Sandra K; Smalley, Susan L; Biederman, Joseph; Kent, Lindsey; Asherson, Philip; Anney, Richard J L; Gaynor, J William; Shaw, Philip; Devoto, Marcella; White, Peter S; Grant, Struan F A; Buxbaum, Joseph D; Rapoport, Judith L; Williams, Nigel M; Nelson, Stanley F; Faraone, Stephen V; Hakonarson, Hakon

    2014-01-01

    Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms. CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 × 10−9). We saw GRM5 (encoding glutamate receptor, metabotropic 5) deletions in ten cases and one control (P = 1.36 × 10−6). We saw GRM7 deletions in six cases, and we saw GRM8 deletions in eight cases and no controls. GRM1 was duplicated in eight cases. We experimentally validated the observed variants using quantitative RT-PCR. A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ~10% of the cases (P = 4.38 × 10−10) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts. PMID:22138692

  17. The DNA damage-inducible dinD gene of Escherichia coli is equivalent to orfY upstream of pyrE

    DEFF Research Database (Denmark)

    Lundegaard, Claus; Jensen, Kaj Frank

    1994-01-01

    The DNA damage-inducible gene dinD, originally identified by Kenyon and Walker (C. J. Kenyon and G. C. Walker, Proc. Natl. Acad. Sci. USA 77:2819-2823, 1980) by selection of the dinD::MudI (Ap lac) fusion, is shown here to be equivalent to the open reading frame orfY near pyrE. The evidence...

  18. Construção de um Vê de Gowin para análises de produções acadêmicas de Enfermagem

    Directory of Open Access Journals (Sweden)

    Cesar Cavalcanti da Silva

    2013-06-01

    Full Text Available O artigo apresenta uma ferramenta da Aprendizagem Significativa denominada V de Gowin e a possibilidade de seu uso em um processo de desempacotamento de produções acadêmicas de Enfermagem. Objetiva construir uma proposta de alteração da ferramenta com a utilização dos elementos que compõem a trajetória processual da Teoria da Intervenção Práxica da Enfermagem em Saúde Coletiva (TIPESC e analisar uma dissertação produzida nesta área de conhecimento. Trata-se de um estudo descritivo e exploratório que apresenta o V de Gowin, propondo alterações no seu domínio metodológico. Constatou-se a possibilidade de utilização para análises de produções acadêmicas de enfermagem deste instrumento heurístico que já se mostrou útil para apoiar processos de ensino e aprendizagem e analisar produções acadêmicas na área, pela capacidade de captar e interpretar qualquer fenômeno articulado aos processos de produção e reprodução social.

  19. Escrita acadêmica e desenvolvimento de autoria na formação de professores via EAD: as universidades estão preparadas?

    Directory of Open Access Journals (Sweden)

    Dorotea Frank Kersch

    2017-07-01

    Full Text Available A demanda crescente por cursos de formação de professores ocasionou o crescimento dos cursos de licenciatura a distância, os quais se tornaram o tipo de graduação em maior número nessa modalidade de ensino. Dentro deste grupo, o curso de Pedagogia é o que conta com maior número de inscritos. Nosso objetivo é identificar as concepções de trabalho acadêmico que três alunas de Pedagogia em EAD demonstram na elaboração de seus Trabalhos de Conclusão de Curso. Além disso, procura-se verificar como a universidade se prepara para a oferta de seus cursos nessa modalidade: de um lado para desenvolver o letramento acadêmico de seus alunos e, por outro, evitar possíveis plágios. Na grade curricular do curso não há previsão de atividades acadêmicas que preparem os alunos para a escrita do trabalho final. Consequentemente, as alunas, com uma concepção equivocada do que seja um trabalho acadêmico e, para fazer o que a universidade lhes pede, recorrem ao plágio. Antes de criminalizar a atitude das alunas, entretanto, é necessário que as universidades revejam práticas de leitura e escrita, de modo especial na modalidade EAD e se preocupem com a qualidade dos cursos que ofertam.

  20. A Duality Theory for Non-convex Problems in the Calculus of Variations

    Science.gov (United States)

    Bouchitté, Guy; Fragalà, Ilaria

    2018-02-01

    We present a new duality theory for non-convex variational problems, under possibly mixed Dirichlet and Neumann boundary conditions. The dual problem reads nicely as a linear programming problem, and our main result states that there is no duality gap. Further, we provide necessary and sufficient optimality conditions, and we show that our duality principle can be reformulated as a min-max result which is quite useful for numerical implementations. As an example, we illustrate the application of our method to a celebrated free boundary problem. The results were announced in Bouchitté and Fragalà (C R Math Acad Sci Paris 353(4):375-379, 2015).

  1. Allelic variation of bile salt hydrolase genes in Lactobacillus salivarius does not determine bile resistance levels.

    LENUS (Irish Health Repository)

    Fang, Fang

    2009-09-01

    Commensal lactobacilli frequently produce bile salt hydrolase (Bsh) enzymes whose roles in intestinal survival are unclear. Twenty-six Lactobacillus salivarius strains from different sources all harbored a bsh1 allele on their respective megaplasmids. This allele was related to the plasmid-borne bsh1 gene of the probiotic strain UCC118. A second locus (bsh2) was found in the chromosomes of two strains that had higher bile resistance levels. Four Bsh1-encoding allele groups were identified, defined by truncations or deletions involving a conserved residue. In vitro analyses showed that this allelic variation was correlated with widely varying bile deconjugation phenotypes. Despite very low activity of the UCC118 Bsh1 enzyme, a mutant lacking this protein had significantly lower bile resistance, both in vitro and during intestinal transit in mice. However, the overall bile resistance phenotype of this and other strains was independent of the bsh1 allele type. Analysis of the L. salivarius transcriptome upon exposure to bile and cholate identified a multiplicity of stress response proteins and putative efflux proteins that appear to broadly compensate for, or mask, the effects of allelic variation of bsh genes. Bsh enzymes with different bile-degrading kinetics, though apparently not the primary determinants of bile resistance in L. salivarius, may have additional biological importance because of varying effects upon bile as a signaling molecule in the host.

  2. El rendimiento académico de estudiantes universitarios del área de psicología: relaciones con el clima organizacional

    Directory of Open Access Journals (Sweden)

    Kethy Pérez Correa

    2017-04-01

    Full Text Available La investigación estuvo orientada a identificar la relación existente entre el rendimiento académico de estudiantes del área de psicología en una universidad pública de Colombia y clima organizacional. Se desarrolló una metodología correlacional y descriptiva con un esquema de campo transaccional y no experimental. El núcleo poblacional estuvo conformado por cuatro (4 directivos, quince (15 docentes y setenta y nueve (79 estudiantes. Para el levantamiento de la información se aplicó como herramienta la encuesta y como instrumentos se diseñaron tres cuestionarios cerrados, con una versión de escala tipo Lickert, conformados por 51 ítems. Los resultados permitieron determinar que las variables estudiadas: clima organizacional y rendimiento académico dentro de la universidad seleccionada para el estudio están estrechamente ligadas, coincidiendo en algunos aspectos entre docentes, estudiantes y directivos y difiriendo en otros. A manera de conclusión, se evidencian tensiones en el clima organizacional como consecuencia de los estilos de dirección, por lo cual, se recomienda la implementación de un conjunto de estrategias para mejorar las condiciones del ambiente laboral y con esto, el rendimiento académico de los estudiantes.

  3. Relación del desempeño académico de estudiantes de primer año de universidad en Chile y los instrumentos de selección para su ingreso

    Directory of Open Access Journals (Sweden)

    Gastón Vergara-Díaz

    2017-01-01

    Full Text Available Si bien el rendimiento académico del estudiantado que ingresa a las universidades chilenas ha sido objeto de múltiples estudios, pocas investigaciones han analizado la relación que tienen los instrumentos de selección de ingreso y el rendimiento académico posterior. En una muestra de 440 estudiantes de Ingeniería Comercial de la Universidad Austral de Chile, pertenecientes a cinco promociones de primer año, se estudiaron los instrumentos de admisión a la carrera, y se determinó cuáles explican mejor el rendimiento académico. Para ello se utilizaron los resultados de las pruebas de selección universitaria (PSU y las notas de enseñanza media (NEM obtenidos por el estudiantado, en relación con el promedio semestral ponderado (PSP del primer año universitario. Se determinó que el promedio de NEM explica mejor el rendimiento académico estudiantil, al presentar la mejor correlación con el rendimiento académico del primer semestre y de manera más fuerte en el segundo.

  4. Coral Cênico UFVJM: um espaço de arte e formação acadêmica

    Directory of Open Access Journals (Sweden)

    José RAFAEL Madureira

    2017-12-01

    Full Text Available O presente trabalho é um relato de experiência do projeto de extensão universitária Coral Cênico UFVJM que visa oferecer à comunidade acadêmica um espaço de estudo e prática do canto coral com ênfase na encenação teatral.

  5. Color differences among feral pigeons (Columba livia) are not attributable to sequence variation in the coding region of the melanocortin-1 receptor gene (MC1R)

    Science.gov (United States)

    2013-01-01

    Background Genetic variation at the melanocortin-1 receptor (MC1R) gene is correlated with melanin color variation in many birds. Feral pigeons (Columba livia) show two major melanin-based colorations: a red coloration due to pheomelanic pigment and a black coloration due to eumelanic pigment. Furthermore, within each color type, feral pigeons display continuous variation in the amount of melanin pigment present in the feathers, with individuals varying from pure white to a full dark melanic color. Coloration is highly heritable and it has been suggested that it is under natural or sexual selection, or both. Our objective was to investigate whether MC1R allelic variants are associated with plumage color in feral pigeons. Findings We sequenced 888 bp of the coding sequence of MC1R among pigeons varying both in the type, eumelanin or pheomelanin, and the amount of melanin in their feathers. We detected 10 non-synonymous substitutions and 2 synonymous substitution but none of them were associated with a plumage type. It remains possible that non-synonymous substitutions that influence coloration are present in the short MC1R fragment that we did not sequence but this seems unlikely because we analyzed the entire functionally important region of the gene. Conclusions Our results show that color differences among feral pigeons are probably not attributable to amino acid variation at the MC1R locus. Therefore, variation in regulatory regions of MC1R or variation in other genes may be responsible for the color polymorphism of feral pigeons. PMID:23915680

  6. Ancestral Variations of the PCDHG Gene Cluster Predispose to Dyslexia in a Multiplex Family

    Directory of Open Access Journals (Sweden)

    Teesta Naskar

    2018-02-01

    Full Text Available Dyslexia is a heritable neurodevelopmental disorder characterized by difficulties in reading and writing. In this study, we describe the identification of a set of 17 polymorphisms located across 1.9 Mb region on chromosome 5q31.3, encompassing genes of the PCDHG cluster, TAF7, PCDH1 and ARHGAP26, dominantly inherited with dyslexia in a multi-incident family. Strikingly, the non-risk form of seven variations of the PCDHG cluster, are preponderant in the human lineage, while risk alleles are ancestral and conserved across Neanderthals to non-human primates. Four of these seven ancestral variations (c.460A > C [p.Ile154Leu], c.541G > A [p.Ala181Thr], c.2036G > C [p.Arg679Pro] and c.2059A > G [p.Lys687Glu] result in amino acid alterations. p.Ile154Leu and p.Ala181Thr are present at EC2: EC3 interacting interface of γA3-PCDH and γA4-PCDH respectively might affect trans-homophilic interaction and hence neuronal connectivity. p.Arg679Pro and p.Lys687Glu are present within the linker region connecting trans-membrane to extracellular domain. Sequence analysis indicated the importance of p.Ile154, p.Arg679 and p.Lys687 in maintaining class specificity. Thus the observed association of PCDHG genes encoding neural adhesion proteins reinforces the hypothesis of aberrant neuronal connectivity in the pathophysiology of dyslexia. Additionally, the striking conservation of the identified variants indicates a role of PCDHG in the evolution of highly specialized cognitive skills critical to reading.

  7. Vivências académicas dos estudantes do curso de Licenciatura em Enfermagem: contributos para a intervenção comunitária

    OpenAIRE

    Costa, Hugo Manuel Ventura

    2015-01-01