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Sample records for aca supplementation strain

  1. Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1β in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy

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    Zueco Jesus

    2009-12-01

    Full Text Available Abstract Background Saccharomyces cerevisiae BY4741 is an auxotrophic commonly used strain. In this work it has been used as host for the expression and secretion of human interleukin-1β (IL1β, using the cell wall protein Pir4 as fusion partner. To achieve high cell density and, consequently, high product yield, BY4741 [PIR4-IL1β] was cultured in an aerated fed-batch reactor, using a defined mineral medium supplemented with casamino acids as ACA (auxotrophy-complementing amino acid source. Also the S. cerevisiae mutant BY4741 Δyca1 [PIR4-IL1β], carrying the deletion of the YCA1 gene coding for a caspase-like protein involved in the apoptotic response, was cultured in aerated fed-batch reactor and compared to the parental strain, to test the effect of this mutation on strain robustness. Viability of the producer strains was examined during the runs and a mathematical model, which took into consideration the viable biomass present in the reactor and the glucose consumption for both growth and maintenance, was developed to describe and explain the time-course evolution of the process for both, the BY4741 parental and the BY4741 Δyca1 mutant strain. Results Our results show that the concentrations of ACA in the feeding solution, corresponding to those routinely used in the literature, are limiting for the growth of S. cerevisiae BY4741 [PIR4-IL1β] in fed-batch reactor. Even in the presence of a proper ACA supplementation, S. cerevisiae BY4741 [PIR4-IL1β] did not achieve a high cell density. The Δyca1 deletion did not have a beneficial effect on the overall performance of the strain, but it had a clear effect on its viability, which was not impaired during fed-batch operations, as shown by the kd value (0.0045 h-1, negligible if compared to that of the parental strain (0.028 h-1. However, independently of their robustness, both the parental and the Δyca1 mutant ceased to grow early during fed-batch runs, both strains using most of the

  2. Strain Dependent Electronic Structure and Band Offset Tuning at Heterointerfaces of ASnO3 (A=Ca, Sr, and Ba) and SrTiO3

    Science.gov (United States)

    Baniecki, John D.; Yamazaki, Takashi; Ricinschi, Dan; Van Overmeere, Quentin; Aso, Hiroyuki; Miyata, Yusuke; Yamada, Hiroaki; Fujimura, Norifumi; Maran, Ronald; Anazawa, Toshihisa; Valanoor, Nagarajan; Imanaka, Yoshihiko

    2017-01-01

    The valence band (VB) electronic structure and VB alignments at heterointerfaces of strained epitaxial stannate ASnO3 (A=Ca, Sr, and Ba) thin films are characterized using in situ X-ray and ultraviolet photoelectron spectroscopies, with band gaps evaluated using spectroscopic ellipsometry. Scanning transmission electron microscopy with geometric phase analysis is used to resolve strain at atomic resolution. The VB electronic structure is strain state dependent in a manner that correlated with a directional change in Sn-O bond lengths with strain. However, VB offsets are found not to vary significantly with strain, which resulted in ascribing most of the difference in band alignment, due to a change in the band gaps with strain, to the conduction band edge. Our results reveal significant strain tuning of conduction band offsets using epitaxial buffer layers, with strain-induced offset differences as large as 0.6 eV possible for SrSnO3. Such large conduction band offset tunability through elastic strain control may provide a pathway to minimize the loss of charge confinement in 2-dimensional electron gases and enhance the performance of photoelectrochemical stannate-based devices. PMID:28195149

  3. Affordable Care Act (ACA)

    Data.gov (United States)

    Social Security Administration — The Affordable Care Act (ACA) is a federal statute enacted with a goal of increasing the quality and affordability of health insurance. Through a web service, CMS...

  4. Tryptophan provision by dietary supplementation of a Bacillus subtilis mutant strain in piglets

    DEFF Research Database (Denmark)

    Torres-Pitarch, A; Nielsen, B.; Canibe, Nuria

    2015-01-01

    Supplementing Bacillus (B.) subtilis mutants selected to overproduce a specific amino acid (AA) may be an alternative method to provide essential AA in pig diets. Two experiments on a B. subtilis strain selected to overproduce Trp were conducted using 8-kg pigs fed Trp-deficient diets for 20 d. B...... to counterbalance the Trp deficiency in any of the two experiments. No effect of B. subtilis supplementation to piglet diets was observed on the plasma AA profile. In conclusion, this mutant strain of B. subtilis was not able to compensate a Trp deficiency in the tested doses....

  5. Whole-Genome Sequence of the Cheese Isolate Lactobacillus rennini ACA-DC 565

    Science.gov (United States)

    Kazou, Maria; Alexandraki, Voula; Pot, Bruno; Tsakalidou, Effie

    2017-01-01

    ABSTRACT In this study, we present the first complete genome sequence of Lactobacillus rennini ACA-DC 565, a strain isolated from a traditional Greek overripened Kopanisti cheese called Mana. Although the species has been associated with cheese spoilage, the strain ACA-DC 565 may contribute to the intense organoleptic characteristics of Mana cheese. PMID:28153908

  6. Inhibitory activity of postbiotic produced by strains of Lactobacillus plantarum using reconstituted media supplemented with inulin

    OpenAIRE

    Kareem, Karwan Yassen; Hooi Ling, Foo; Teck Chwen, Loh; May Foong, Ooi; Anjas Asmara, Samsudin

    2014-01-01

    Background The present study aimed to determine the inhibitory activity of postbiotic produced by L. plantarum using reconstituted media supplemented with different levels of inulin and to select the best combination based on the modified inhibitory activity (MAU/mL) against pathogens. Methods Postbiotics were produced by 6 strains of L. plantarum (RG11, RG14, RI11, UL4, TL1 and RS5) using reconstituted media supplemented with different levels of Inulin (0, 0.2, 0.4, 0.6, 0.8, and 1.0) yieldi...

  7. Influência da suplementação de creatina na capacidade funcional de pacientes com Insuficiência Cardíaca Influence of creatine supplementation on the functional capacity of patients with Heart Failure

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    Ana Paula Perillo Ferreira Carvalho

    2012-07-01

    Full Text Available FUNDAMENTO: A Insuficiência Cardíaca (IC é uma síndrome complexa, marcada pela intolerância ao esforço e perda da capacidade funcional. OBJETIVO: Avaliar a capacidade funcional dos pacientes com IC suplementados com creatina. MÉTODOS: Estudo prospectivo, randomizado, duplo cego. Foram randomizados em dois grupos 33 pacientes com IC, com idade > 18 anos, sexo masculino, classes funcionais II a IV. O grupo experimental (G CRE, n = 17 foi suplementado com creatina com dose de 5 g por dia durante seis meses. E o grupo placebo (G PLA, n = 16 recebeu 5 g de maltodextrina por dia durante o mesmo período de tempo. Ambos os grupos foram submetidos a avaliação da capacidade funcional por meio da ergoespirometria e teste de caminhada de seis minutos (TC6 pré e pós-intervenção. O modelo estatístico Ancova e a correlação de Pearson foram utilizados na análise dos grupos e nas formas de tratamento. RESULTADOS: Das variáveis avaliadas na ergoespirometria, o volume de oxigênio pico (VO2 pico, limiar anaeróbio (LA e o pulso de oxigênio (pulso de O2 não apresentaram diferenças significativas entre os grupos (P>0,05. No TC6 não houve diferença significativa na distância percorrida. CONCLUSÃO: A suplementação de creatina em pacientes com IC não promoveu melhora significativa na capacidade funcional.BACKGROUND: Heart failure (HF is a complex syndrome characterized by intolerance to exertion and reduced functional capacity. OBJECTIVE: To assess the functional capacity of patients with HF and supplemented with creatine. METHODS: Prospective, randomized, double-blind study. Thirty-three male patients over the age of 18 years with functional class II to IV HF were randomized into two groups as follows: the experimental group (CRE, n = 17, supplemented with 5 g/day of creatine for six months; and the placebo group (PLA, n = 16, receiving 5 g/day of maltodextrin for that same period. Both groups underwent functional capacity assessment by

  8. Caquexia cardíaca

    OpenAIRE

    A. Miján de la Torre; E. Martín de la Torre; de Mateo Silleras, Beatriz

    2006-01-01

    La insuficiencia cardíaca de carácter crónico (ICC), en especial si afecta al corazón derecho, ocasiona con frecuencia malnutrición. Si esta es grave y se unen otros componentes, puede producirse caquexia cardíaca. Esta se asocia a mayor morbilidad y menor supervivencia de los pacientes que la padecen. Las causas de la caquexia cardíaca son diversas, en general asociadas a mantener balance energético negativo, surgiendo cada vez mayor evidencia que apoya un origen multifactorial de la m...

  9. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants

    Science.gov (United States)

    Berni Canani, Roberto; Sangwan, Naseer; Stefka, Andrew T; Nocerino, Rita; Paparo, Lorella; Aitoro, Rosita; Calignano, Antonio; Khan, Aly A; Gilbert, Jack A; Nagler, Cathryn R

    2016-01-01

    Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow's milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based operational taxonomic unit clustering and oligotyping. Differential feature selection and generalized linear model fitting revealed that the CMA infants have a diverse gut microbial community structure dominated by Lachnospiraceae (20.5±9.7%) and Ruminococcaceae (16.2±9.1%). Blautia, Roseburia and Coprococcus were significantly enriched following treatment with EHCF and LGG, but only one genus, Oscillospira, was significantly different between infants that became tolerant and those that remained allergic. However, most tolerant infants showed a significant increase in fecal butyrate levels, and those taxa that were significantly enriched in these samples, Blautia and Roseburia, exhibited specific strain-level demarcations between tolerant and allergic infants. Our data suggest that EHCF+LGG promotes tolerance in infants with CMA, in part, by influencing the strain-level bacterial community structure of the infant gut. PMID:26394008

  10. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants.

    Science.gov (United States)

    Berni Canani, Roberto; Sangwan, Naseer; Stefka, Andrew T; Nocerino, Rita; Paparo, Lorella; Aitoro, Rosita; Calignano, Antonio; Khan, Aly A; Gilbert, Jack A; Nagler, Cathryn R

    2016-03-01

    Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow's milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based operational taxonomic unit clustering and oligotyping. Differential feature selection and generalized linear model fitting revealed that the CMA infants have a diverse gut microbial community structure dominated by Lachnospiraceae (20.5±9.7%) and Ruminococcaceae (16.2±9.1%). Blautia, Roseburia and Coprococcus were significantly enriched following treatment with EHCF and LGG, but only one genus, Oscillospira, was significantly different between infants that became tolerant and those that remained allergic. However, most tolerant infants showed a significant increase in fecal butyrate levels, and those taxa that were significantly enriched in these samples, Blautia and Roseburia, exhibited specific strain-level demarcations between tolerant and allergic infants. Our data suggest that EHCF+LGG promotes tolerance in infants with CMA, in part, by influencing the strain-level bacterial community structure of the infant gut.

  11. The complete genome sequence of the yogurt isolate Streptococcus thermophilus ACA-DC 2.

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    Alexandraki, Voula; Kazou, Maria; Blom, Jochen; Pot, Bruno; Tsakalidou, Effie; Papadimitriou, Konstantinos

    2017-01-01

    Streptococcus thermophilus ACA-DC 2 is a newly sequenced strain isolated from traditional Greek yogurt. Among the 14 fully sequenced strains of S. thermophilus currently deposited in the NCBI database, the ACA-DC 2 strain has the smallest chromosome, containing 1,731,838 bp. The annotation of its genome revealed the presence of 1,850 genes, including 1,556 protein-coding genes, 70 RNA genes and 224 potential pseudogenes. A large number of pseudogenes were identified. This was also accompanied by the absence of pathogenic features suggesting evolution of strain ACA-DC 2 through genome decay processes, most probably due to adaptation to the milk ecosystem. Analysis revealed the existence of one complete lactose-galactose operon, several proteolytic enzymes, one exopolysaccharide cluster, stress response genes and four putative antimicrobial peptides. Interestingly, one CRISPR-cas system and one orphan CRISPR, both carrying only one spacer, were predicted indicating low activity or inactivation of the cas proteins. Nevertheless, four putative restriction-modification systems were determined that may compensate any deficiencies of the CRISPR-cas system. Furthermore, whole genome phylogeny indicated three distinct clades within S. thermophilus. Comparative analysis among selected strains representative for each clade, including strain ACA-DC 2, revealed a high degree of conservation at the genomic scale, but also strain specific regions. Unique genes and genomic islands of strain ACA-DC 2 contained a number of genes potentially acquired through horizontal gene transfer events, that could be related to important technological properties for dairy starters. Our study suggests genomic traits in strain ACA-DC 2 compatible to the production of dairy fermented foods.

  12. Falla cardíaca (primera parte)

    OpenAIRE

    2006-01-01

    Anatomía y función del corazón/¿Qué es la falla cardíaca?/Causas de falla cardíaca/¿Cómo prevenir la falla cardíaca?/¿Qué es un factor de riesgo?/¿Cuáles son los síntomas y signos de la falla cardiaca?/¿Cómo se diagnostica la falla cardiaca?

  13. Malondialdeído e troponina I cardíaca em equinos da raça Puro Sangue Árabe submetidos ao exercício e à suplementação com vitamina E Malondialdehyde and cardiac troponin I in Arabian horses subjected to exercise and vitamin E supplementation

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    Letícia Andreza Yonezawa

    2010-06-01

    Full Text Available Para avaliar o efeito do exercício físico, do treinamento e da suplementação com vitamina E sobre o malondialdeído (MDA e a troponina I cardíaca (cTnI séricos, foram utilizados 16 equinos da raça Puro Sangue Árabe, sem treinamento, divididos em dois grupos de oito: controle e suplementado com vitamina E. Ambos os grupos foram submetidos a provas de exercício progressivo em esteira de alta velocidade inclinada a +7%, antes (P1 e após (P2 o período de treinamento de 20 dias. Foram determinadas as concentrações séricas de MDA, vitamina E e cTnI e realizou-se o eletrocardiograma de repouso antes e após as provas P1 e P2. Os resultados sugerem a ocorrência do estresse oxidativo ocasionado pelo exercício, determinado por meio do aumento de MDA sérico. Em alguns animais, houve um discreto aumento de cTnI associado à detecção de complexos ventriculares prematuros, mas que não representou lesão cardíaca expressiva. Não houve efeito do treinamento sobre o estresse oxidativo. Portanto, é possível concluir que o exercício físico progressivo promoveu a lipoperoxidação nessas condições, que não foi prevenida pela suplementação com vitamina E nem pelo treinamento, mas não foi suficiente para causar uma lesão cardíaca significativa.To evaluate the effect of exercise, training and vitamin E supplementation on serum malondialdehyde (MDA and cardiac troponin I (cTnI, sixteen adult untrained Arabian horses were divided into 2 groups of 8 animals each, control and supplemented with vitamin E. Both groups had incremental exercise tests performed on a high-speed treadmill at a +7% slope, before (P1 and after (P2 a training period of 20 days. Serum concentrations of MDA, vitamin E and cTnI, and resting electrocardiogram were performed before and after P1 and P2. Results suggested that oxidative stress was induced by exercise as measured by serum MDA increase. In some animals, there was a subtle increase in cTnI concentration

  14. Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals.

    Science.gov (United States)

    Kim, Minkyung; Kim, Minjoo; Kang, Miso; Yoo, Hye Jin; Kim, Min Sun; Ahn, Young-Tae; Sim, Jae-Hun; Jee, Sun Ha; Lee, Jong Ho

    2017-01-25

    Our previous study showed that supplementation with a combination of Lactobacillus curvatus (L. curvatus) HY7601 and Lactobacillus plantarum (L. plantarum) KY1032 reduced the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area in overweight subjects. We aimed to evaluate whether the changes in adiposity after supplementation with Lactobacillus strains were associated with metabolic intermediates. A randomized, double-blind, placebo-controlled study was conducted on 66 non-diabetic and overweight individuals. Over a 12-week period, the probiotic group consumed 2 g of probiotic powder, whereas the placebo group consumed the same product without the probiotics. To investigate metabolic alterations, we performed plasma metabolomics using ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS). Probiotic supplementation significantly increased the levels of octenoylcarnitine (C8:1), tetradecenoylcarnitine (C14:1), decanoylcarnitine (C10) and dodecenoylcarnitine (C12:1) compared with the levels from placebo supplementation. In the probiotic group, the changes in the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area were negatively associated with changes in the levels of C8:1, C14:1, C10 and C12:1 acylcarnitines. In overweight individuals, probiotic-induced weight loss and adiposity reduction from the probiotic supplementation were associated with an increase in medium-chain acylcarnitines.

  15. Chronic omega-3 supplementation in seizure-prone versus seizure-resistant rat strains: a cautionary tale.

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    Gilby, K L; Jans, J; McIntyre, D C

    2009-10-20

    Several studies have shown fatty acid supplementation to be efficacious in the treatment of attention deficit hyperactivity disorder/autism spectrum disorder (ADHD/ASD) and epilepsy. Interestingly, rats bred to be seizure-prone (Fast), unlike those bred for seizure-resistance (Slow), naturally exhibit behaviors and physiology reminiscent of ADHD/ASD in humans, suggesting a fundamental link between seizure disposition and these developmental disorders. To determine whether chronic omega-3 supplementation might ameliorate ADHD-like behaviors in the seizure-prone rat strain and/or alter natural predispositions for or against seizure in either strain, Fast and Slow weanlings were maintained on a control or omega-3-supplemented diet. As adults, rats were tested in paradigms known to elicit ADHD-like behaviors from Fast rats and then kindled from the amygdala to assess relative seizure disposition. While omega-3 supplementation did not significantly alter the relative hyperactivity, learning deficits or heightened seizure sensitivity naturally exhibited by Fast rats, it dramatically reduced their impulsivity to Slow-like levels. In contrast, typical behavioral patterns in Slow rats were largely unaffected by omega-3 supplementation yet their proclivity for seizure was greatly increased. This heightened vulnerability to seizure in Slow rats was paralleled by a drop in circulating plasma non-esterified fatty acids (NEFA) to match levels normally observed in Fast rats. These findings suggest a delicate balance between seizure predisposition and ADHD-like behaviors that can be influenced by omega-3 treatment. Further, a relationship between circulating NEFA levels and seizure susceptibility has surfaced that advocates caution when treating different genetic backgrounds with omega-3 fatty acids.

  16. Removal of cephalosporin antibiotics 7-ACA from wastewater during the cultivation of lipid-accumulating microalgae.

    Science.gov (United States)

    Guo, Wan-Qian; Zheng, He-Shan; Li, Shuo; Du, Juan-Shan; Feng, Xiao-Chi; Yin, Ren-Li; Wu, Qing-Lian; Ren, Nan-Qi; Chang, Jo-Shu

    2016-12-01

    The aim of this study is to evaluate the feasibility of using lipid-accumulating microalgae to remove cephalosporin antibiotics 7-amino cephalosporanic acid (7-ACA) from wastewater with the additional benefit of biofuels production. Three isolated microalgal strains (namely, Chlorella sp. Cha-01, Chlamydomonas sp. Tai-03 and Mychonastes sp. YL-02) were cultivated under 7-ACA stress and their biomass productivity, lipid production and N-NO3(-) consumption were monitored. It was found that 7-ACA had slight inhibition effects on the microalgal growth at the ratio of 12.0% (Cha-01), 9.6% (YL-02), 11.7% (Tai-03). However, lipid accumulation in the three microalgae was not influenced by the presence of 7-ACA. The investigation on the 7-ACA removal mechanisms during microalgal growth shows that 7-ACA was mainly removed by microalgae adsorption as well as hydrolysis and photolysis reactions. This study demonstrates that using microalgae to treat antibiotic-containing wastewater is promising due to the potential of simultaneous antibiotic removal and biofuel production. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Effects of nutritional supplementation with l-arginine on repair of injuries due to muscle strain: experimental study on rats

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    Lauren Izabel Medeiros Couto

    2015-08-01

    Full Text Available ABSTRACTOBJECTIVE: To evaluate the influence of oral supplementation with arginine on regeneration of injuries due to straining of the anterior tibial muscle of rats. METHODS: Twenty-four Wistar rats of weight 492.5 ± 50.45 g were used. Injuries were induced through straining the anterior tibial muscles. The rats were separated into three groups of eight rats each. In the untreated group (UTG, after induction of injuries, the rats were observed for 24 h. In the simulation group (SG and the arginine group (AG respectively, the rats received isotonic saline solution and arginine solution via direct gavage, over a seven-day period. At the end of the period, blood samples were collected for serum evaluations of creatine kinase (CK, lactic dehydrogenase (LDH, aspartate aminotransferase (AST and C-reactive protein (CRP. The right and left anterior tibial muscles were resected for histopathological evaluations on the muscle injuries, investigating edema, hemorrhage and disorganization or morphometric alteration of the muscle fibers. The tissue repair was investigated in terms of proliferation of adipose tissue, angiogenesis and collagen fibers. The ANOVA and Student's tmethods were used and p≤ 0.05 was taken to be statistically significant. RESULTS: In the serum evaluations, the AG showed lower CK assay values and higher AST values. In the histopathological evaluation, the UTG presented edema and hemorrhage compatible with injuries due to strain; the SG presented edema and hemorrhage with proliferation of adipose tissue and collagen fibers; and the AG presented not only the findings of the SG but also, especially, intense angiogenesis. CONCLUSION: Oral supplementation with arginine did not cause any significant metabolic alterations that would contraindicate its use and it induced angiogenesis during the repair of muscles injured due to strain.

  18. Insuficiencia cardíaca y diabetes

    OpenAIRE

    Jorge Thierer

    2006-01-01

    La prevalencia de la insuficiencia cardíaca y la diabetes continúa creciendo. Ambas están fuertemente asociadas. La diabetes es un fuerte predictor de aparición de insuficiencia cardíaca. Las razones son la presencia de enfermedad coronaria y los trastornos metabólicos vinculados con la resistencia a la insulina que generan disfunción contráctil. Los pacientes con insuficiencia cardíaca que son diabéticos tienen peor evolución. Los Betabloqueantes, vasodilatadores y los inhibidores de la en...

  19. Complete Genome Sequence of the Dairy Isolate Lactobacillus acidipiscis ACA-DC 1533

    Science.gov (United States)

    Kazou, Maria; Alexandraki, Voula; Pot, Bruno; Tsakalidou, Effie

    2017-01-01

    ABSTRACT Lactobacillus acidipiscis is a Gram-positive lactic acid bacterium belonging to the Lactobacillus salivarius clade. Here, we present the first complete genome sequence of L. acidipiscis isolated from traditional Greek Kopanisti cheese. Strain ACA-DC 1533 may play a key role in the strong organoleptic characteristics of Kopanisti cheese. PMID:28126948

  20. Determination and Analysis of the Putative AcaCD-Responsive Promoters of Salmonella Genomic Island 1

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    Olasz, Ferenc; Kiss, János

    2016-01-01

    The integrative genomic island SGI1 and its variants confer multidrug resistance in numerous Salmonella enterica serovariants and several Proteus mirabilis and Acinetobacter strains. SGI1 is mobilized by the IncA/C family plasmids. The island exploits not only the conjugation apparatus of the plasmid, but also utilizes the plasmid-encoded master regulator AcaCD to induce the excision and formation of its transfer-competent form, which is a key step in the horizontal transfer of SGI1. Triggering of SGI1 excision occurs via the AcaCD-dependent activation of xis gene expression. AcaCD binds in Pxis to an unusually long recognition sequence. Beside the Pxis promoter, upstream regions of four additional SGI1 genes, S004, S005, S012 and S018, also contain putative AcaCD-binding sites. Furthermore, SGI1 also encodes an AcaCD-related activator, FlhDCSGI1, which has no known function. Here, we have analysed the functionality of the putative AcaCD-dependent promoter regions and proved their activation by either AcaCD or FlhDCSGI1. Moreover, we provide evidence that both activators act on the same binding site in Pxis and that FlhDCSGI1 is able to complement the acaCD deletion of the IncA/C family plasmid R16a. We determined the transcription start sites for the AcaCD-responsive promoters and showed that orf S004 is expressed probably from a different start codon than predicted earlier. Additionally, expression of S003 from promoter PS004 was ruled out. Pxis and the four SGI1 promoters examined here also lack obvious -35 promoter box and their promoter profile is consistent with the class II-type activation pathway. Although the role of the four additionally analysed AcaCD/FlhDCSGI1-controlled genes in transfer and/or maintenance of SGI1 is not yet clear, the conservation of the whole region suggests the existence of some selection for their functionality. PMID:27727307

  1. Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

    Directory of Open Access Journals (Sweden)

    Cesare de Gregorio

    2017-06-01

    Full Text Available Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS, but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11 or placebo (n = 11 in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurements. Also, left atrial (LA morphofunctional indices were investigated at baseline and at the final visit. Results were expressed as median with interquartile range (IQ. A significant improvement of LV ejection fraction (20.3 (IQ 12.5 vs. −1.67 (IQ 24.8; p = 0.040, and LA area fractional change (11.1 (IQ 22.6 vs. 2.8 (9.5; p = 0.034 were observed in genistein patients compared to the controls, following 12 months of treatment. In addition, body surface area indexed LA systolic volume and peak LA longitudinal strain significantly changed from basal to the end of the study in genistein-treated patients. One-year supplementation with 54 mg/day of pure genistein improved both LV ejection fraction and LA remodeling and function in postmenopausal women with MetS.

  2. THE EFFECT OF PROBIOTICS SUPPLEMENTATION ON THE GROWTH PERFORMANCE OF TWO STRAINS OF COCKERELS

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    ANDREW ADEGBOYEGA FATUFE

    2009-03-01

    Full Text Available In a 2 × 3 factorial design, two hundred and seven 3 weeks old black (Bovan Nera and white (Gold line cockerels were randomly assigned to three dietary treatments. The basal diet was based on maize, soybean meal, groundnut cake and wheat offal. Probiotics replaced the wheat offal in Diets I, II and III in proportion of 0, 0.05 and 0.1%. Probiotics contained Lactobacillus acidophilus, Saccharomyces cerevisae and Saccharomyces boulardii. Each diet was offered to 3 pens of 12 black cockerels each or 3 pens of 11 white cockerels each. Starting chicken of both strains responded non-significantly to increasing probiotics concentration in feed intake, body weight gain, and feed/gain ratio. A nonsignificant interaction occurred between strain and dietary probiotics concentration for all response criteria. The slope of regression of body weight changes depending on age was higher for white than black.

  3. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions.

    Science.gov (United States)

    Faseleh Jahromi, Mohammad; Wesam Altaher, Yassir; Shokryazdan, Parisa; Ebrahimi, Roohollah; Ebrahimi, Mahdi; Idrus, Zulkifli; Tufarelli, Vincenzo; Liang, Juan Boo

    2016-07-01

    High ambient temperature is a major problem in commercial broiler production in the humid tropics because high producing broiler birds consume more feed, have higher metabolic activity, and thus higher body heat production. To evaluate the effects of two previously isolated potential probiotic strains (Lactobacillus pentosus ITA23 and Lactobacillus acidophilus ITA44) on broilers growing under heat stress condition, a total of 192 chicks were randomly allocated into four treatment groups of 48 chickens each as follows: CL, birds fed with basal diet raised in 24 °C; PL, birds fed with basal diet plus 0.1 % probiotic mixture raised in 24 °C; CH, birds fed with basal diet raised in 35 °C; and PH, birds fed with basal diet plus 0.1 % probiotic mixture raised in 35 °C. The effects of probiotic mixture on the performance, expression of nutrient absorption genes of the small intestine, volatile fatty acids (VFA) and microbial population of cecal contents, antioxidant capacity of liver, and fatty acid composition of breast muscle were investigated. Results showed that probiotic positively affected the final body weight under both temperature conditions (PL and PH groups) compared to their respective control groups (CL and CH). Probiotic supplementation numerically improved the average daily gain (ADG) under lower temperature, but significantly improved ADG under the higher temperature (P heat stress condition. The two Lactobacillus strains also improved the fatty acid profile of meat, including at heat stress. Generally, the two Lactobacillus strains can be considered as good potential probiotics for chickens due to their good probiotic properties and remarkable efficacy on broiler chickens.

  4. Entendiendo la insuficiencia cardíaca

    OpenAIRE

    Guadalajara Boo,José Fernando

    2006-01-01

    La insuficiencia cardíaca es una enfermedad de la que existen múltiples definiciones y el concepto es adoptado en forma arbitraria por cada autor, de tal manera que la terminología es tan confusa actualmente que los autores de los megaestudios en el tratamiento médico de insuficiencia cardíaca, evitan denominar así a la enfermedad que van a tratar y sólo se concretan a indicar que la fracción de expulsión es < de 40 o de 35%. En este escrito, el objetivo es el denominar puntualmente los conce...

  5. Entendiendo la insuficiencia cardíaca

    OpenAIRE

    Guadalajara Boo,José Fernando

    2006-01-01

    La insuficiencia cardíaca es una enfermedad de la que existen múltiples definiciones y el concepto es adoptado en forma arbitraria por cada autor, de tal manera que la terminología es tan confusa actualmente que los autores de los megaestudios en el tratamiento médico de insuficiencia cardíaca, evitan denominar así a la enfermedad que van a tratar y sólo se concretan a indicar que la fracción de expulsión es < de 40 o de 35%. En este escrito, el objetivo es el denominar puntualmente los conce...

  6. Screening of Bacillus coagulans strains in lignin supplemented minimal medium with high throughput turbidity measurements

    Directory of Open Access Journals (Sweden)

    Robert Glaser

    2014-12-01

    Full Text Available The aim of this study was to extend the options for screening and characterization of microorganism through kinetic growth parameters. In order to obtain data, automated turbidimetric measurements were accomplished to observe the response of strains of Bacillus coagulans. For the characterization, it was decided to examine the influence of varying concentrations of lignin with respect to bacterial growth. Different mathematical models are used for comparison: logistic, Gompertz, Baranyi and Richards and Stannard. The growth response was characterized by parameters like maximum growth rate, maximum population, and the lag time. In this short analysis we present a mathematical approach towards a comparison of different microorganisms. Furthermore, it can be demonstrated that lignin in low concentrations can have a positive influence on the growth of B. coagulans.

  7. Effect of isolate of ruminal fibrolytic bacterial culture supplementation on fibrolytic bacterial population and survivability of inoculated bacterial strain in lactating Murrah buffaloes

    Directory of Open Access Journals (Sweden)

    Brishketu Kumar

    2013-02-01

    Full Text Available Aim: The present study was conducted to evaluate the effect of bacterial culture supplementation on ruminal fibrolytic bacterial population as well as on survivability of inoculated bacterial strain in lactating Murrah buffaloes kept on high fibre diet. Materials and Methods: Fibrolytic bacterial strains were isolated from rumen liquor of fistulated Murrah buffaloes and live bacterial culture were supplemented orally in treatment group of lactating Murrah buffaloes fed on high fibre diet to see it's effect on ruminal fibrolytic bacterial population as well as to see the effect of survivability of the inoculated bacterial strain at three different time interval in comparison to control group. Results: It has been shown by real time quantification study that supplementation of bacterial culture orally increases the population of major fibre degrading bacteria i.e. Ruminococcus flavefaciens, Ruminococcus albus as well as Fibrobacter succinogenes whereas there was decrease in secondary fibre degrading bacterial population i.e. Butyrivibrio fibrisolvens over the different time periods. However, the inoculated strain of Ruminococcus flavefaciens survived significantly over the period of time, which was shown in stability of increased inoculated bacterial population. Conclusion: The isolates of fibrolytic bacterial strains are found to be useful in increasing the number of major ruminal fibre degrading bacteria in lactating buffaloes and may act as probiotic in large ruminants on fibre-based diets. [Vet World 2013; 6(1.000: 14-17

  8. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions

    Science.gov (United States)

    Faseleh Jahromi, Mohammad; Wesam Altaher, Yassir; Shokryazdan, Parisa; Ebrahimi, Roohollah; Ebrahimi, Mahdi; Idrus, Zulkifli; Tufarelli, Vincenzo; Liang, Juan Boo

    2016-07-01

    High ambient temperature is a major problem in commercial broiler production in the humid tropics because high producing broiler birds consume more feed, have higher metabolic activity, and thus higher body heat production. To evaluate the effects of two previously isolated potential probiotic strains ( Lactobacillus pentosus ITA23 and Lactobacillus acidophilus ITA44) on broilers growing under heat stress condition, a total of 192 chicks were randomly allocated into four treatment groups of 48 chickens each as follows: CL, birds fed with basal diet raised in 24 °C; PL, birds fed with basal diet plus 0.1 % probiotic mixture raised in 24 °C; CH, birds fed with basal diet raised in 35 °C; and PH, birds fed with basal diet plus 0.1 % probiotic mixture raised in 35 °C. The effects of probiotic mixture on the performance, expression of nutrient absorption genes of the small intestine, volatile fatty acids (VFA) and microbial population of cecal contents, antioxidant capacity of liver, and fatty acid composition of breast muscle were investigated. Results showed that probiotic positively affected the final body weight under both temperature conditions (PL and PH groups) compared to their respective control groups (CL and CH). Probiotic supplementation numerically improved the average daily gain (ADG) under lower temperature, but significantly improved ADG under the higher temperature ( P Lactobacillus strains significantly increased the expression of the four sugar transporter genes tested (GLUT2, GLUT5, SGLT1, and SGLT4) indicating probiotic enhances the absorption of this nutrient. Similar but less pronounced effect was also observed under higher temperature (35 °C) condition. In addition, the probiotic mixture improved bacterial population of the cecal contents, by increasing beneficial bacteria and decreasing Escherichia coli population, which could be because of higher production of VFA in the cecum, especially at heat stress condition. The two Lactobacillus

  9. Insuficiencia cardíaca y diabetes

    Directory of Open Access Journals (Sweden)

    Jorge Thierer

    2006-01-01

    Full Text Available La prevalencia de la insuficiencia cardíaca y la diabetes continúa creciendo. Ambas están fuertemente asociadas. La diabetes es un fuerte predictor de aparición de insuficiencia cardíaca. Las razones son la presencia de enfermedad coronaria y los trastornos metabólicos vinculados con la resistencia a la insulina que generan disfunción contráctil. Los pacientes con insuficiencia cardíaca que son diabéticos tienen peor evolución. Los Betabloqueantes, vasodilatadores y los inhibidores de la enzima convertidora ejercen una influencia favorable, en tanto que el uso de glitazonas todavía es controversial. La insuficiencia cardíaca puede a su vez generar diabetes, debido a la activación del sistema nervioso simpático y al efecto del tratamiento. La comprensión adecuada de estos hechos es fundamental para tomar decisiones correctas y mejorar la suerte de los pacientes.

  10. EHS & LCA assessment for 7-ACA synthesis

    DEFF Research Database (Denmark)

    Henderson, Richard K; Jiménez-González, Concepción; Preston, Chris

    2008-01-01

    A Green Technology Comparison framework incorporating a life cycle approach and sustainability metrics has been used to compare the performance, and the environment, health, safety, and life cycle impacts of two synthetic methods used to produce 7-aminocephalosporic acid (7-ACA). The routes under...

  11. Effect of Probiotic Strain Enterococcus faecium M74 Supplementation on the Carcass Parameters of Different Hybrid Combination Chickens

    Directory of Open Access Journals (Sweden)

    Ján Weis

    2011-05-01

    Full Text Available The aim of the present study was to evaluate the effect of addition of Enterococcus faecium M74 in drinking water on performance and carcass characteristics of broiler chickens. Totally 120 chickens (60 of hybrid Hybro, 60 of Ross 308 were divided to two groups. Experimental chickens of Hybro (n=30 and Ross 308 (n=30 received a probiotic preparation in drinking water from day 1 to day 42 with concentration of 2x109 CFU of Enterococcus faecium M 74 in 1 g of nutrient medium with dextrose. The control group of Hybro (n=30 and Ross 308 (n=30 received water in same total amount as experimental group without any additives. The feeding period lasted 42 days. In case of Hybro, we showed higher effect of Enterococcus faecium M74 supplementation on slaughter weight (1807.51 vs. 1929.08 g; P0.05 in comparison with Ross 308 (2126.63 vs. 2199.31g; P>0.05. Differences in percentage of valuable parts (thigh and breast and carcass yield of Hybro and Ross 308 were not statistically significant (P>0.05 by addition of probiotic On the end of fattening, Ross 308 broiler chickens fed diet with probiotic strain Enterococcus faecium had significantly less (P<0.05 abdominal fat than those fed without the probiotic. In Hybro broiler chickens we recorded not significant difference between groups (P>0.05.

  12. Purification and characterization of thermophilin T, a novel bacteriocin produced by Streptococcus thermophilus ACA-DC 0040

    NARCIS (Netherlands)

    Aktypis, A.; Kalantzopoulos, G.; Huis Veld,in't J.H.J.; Brink, B. ten

    1998-01-01

    ACA-DC 0040 produced an antimicrobial agent, which was named thermophilin T, active against several lactic acid bacteria strains of different species and food spoilage bacteria, such as Clostridium sporogenes C22/10 and Cl. tyrobutyricum NCDO-1754. The crude antimicrobial compound is sensitive to pr

  13. Purification and characterization of thermophilin T, a novel bacteriocin produced by Streptococcus thermophilus ACA-DC 0040

    NARCIS (Netherlands)

    Aktypis, A.; Kalantzopoulos, G.; Huis Veld,in't J.H.J.; Brink, B. ten

    1998-01-01

    ACA-DC 0040 produced an antimicrobial agent, which was named thermophilin T, active against several lactic acid bacteria strains of different species and food spoilage bacteria, such as Clostridium sporogenes C22/10 and Cl. tyrobutyricum NCDO-1754. The crude antimicrobial compound is sensitive to pr

  14. Purification and characterization of thermophilin T, a novel bacteriocin produced by Streptococcus thermophilus ACA-DC 0040

    NARCIS (Netherlands)

    Aktypis, A.; Kalantzopoulos, G.; Huis Veld,in't J.H.J.; Brink, B. ten

    1998-01-01

    ACA-DC 0040 produced an antimicrobial agent, which was named thermophilin T, active against several lactic acid bacteria strains of different species and food spoilage bacteria, such as Clostridium sporogenes C22/10 and Cl. tyrobutyricum NCDO-1754. The crude antimicrobial compound is sensitive to

  15. Development of a rapid SNP-typing assay to differentiate Bifidobacterium animalis ssp. lactis strains used in probiotic-supplemented dairy products.

    Science.gov (United States)

    Lomonaco, Sara; Furumoto, Emily J; Loquasto, Joseph R; Morra, Patrizia; Grassi, Ausilia; Roberts, Robert F

    2015-02-01

    Identification at the genus, species, and strain levels is desirable when a probiotic microorganism is added to foods. Strains of Bifidobacterium animalis ssp. lactis (BAL) are commonly used worldwide in dairy products supplemented with probiotic strains. However, strain discrimination is difficult because of the high degree of genome identity (99.975%) between different genomes of this subspecies. Typing of monomorphic species can be carried out efficiently by targeting informative single nucleotide polymorphisms (SNP). Findings from a previous study analyzing both reference and commercial strains of BAL identified SNP that could be used to discriminate common strains into 8 groups. This paper describes development of a minisequencing assay based on the primer extension reaction (PER) targeting multiple SNP that can allow strain differentiation of BAL. Based on previous data, 6 informative SNP were selected for further testing, and a multiplex preliminary PCR was optimized to amplify the DNA regions containing the selected SNP. Extension primers (EP) annealing immediately adjacent to the selected SNP were developed and tested in simplex and multiplex PER to evaluate their performance. Twenty-five strains belonging to 9 distinct genomic clusters of B. animalis ssp. lactis were selected and analyzed using the developed minisequencing assay, simultaneously targeting the 6 selected SNP. Fragment analysis was subsequently carried out in duplicate and demonstrated that the assay yielded 8 specific profiles separating the most commonly used commercial strains. This novel multiplex PER approach provides a simple, rapid, flexible SNP-based subtyping method for proper characterization and identification of commercial probiotic strains of BAL from fermented dairy products. To assess the usefulness of this method, DNA was extracted from yogurt manufactured with and without the addition of B. animalis ssp. lactis BB-12. Extracted DNA was then subjected to the minisequencing

  16. Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study.

    Science.gov (United States)

    Merenstein, Daniel J; Tan, Tina P; Molokin, Aleksey; Smith, Keisha Herbin; Roberts, Robert F; Shara, Nawar M; Mete, Mihriye; Sanders, Mary Ellen; Solano-Aguilar, Gloria

    2015-01-01

    Probiotics are live microorganisms that, when administered in sufficient doses, provide health benefits on the host. The United States Food and Drug Administration (FDA) requires phase I safety studies for probiotics when the intended use of the product is as a drug. The purpose of the study was to determine the safety of Bifidobacterium animalis subsp lactis (B. lactis) strain BB-12 (BB-12)-supplemented yogurt when consumed by a generally healthy group of adults who were prescribed a 10-day course of antibiotics for a respiratory infection. Secondary aims were to assess the ability of BB-12 to affect the expression of whole blood immune markers associated with cell activation and inflammatory response. A phase I, double-blinded, randomized controlled study was conducted in compliance with FDA guidelines for an Investigational New Drug (IND). Forty participants were randomly assigned to consume 4 ounces of either BB-12 -supplemented yogurt or non-supplemented control yogurt daily for 10 d. The primary outcome was to assess safety and tolerability, assessed by the number of reported adverse events. A total of 165 non-serious adverse events were reported, with no differences between the control and BB-12 groups. When compared to the control group, B lactis fecal levels were modestly higher in the BB-12-supplemented group. In a small subset of patients, changes in whole blood expression of genes associated with regulation and activation of immune cells were detected in the BB-12-supplemented group. BB-12-supplemented yogurt is safe and well tolerated when consumed by healthy adults concurrently taking antibiotics. This study will form the basis for future randomized clinical trials investigating the potential immunomodulatory effects of BB-12-supplemented yogurt in a variety of disease states.

  17. The study of antiviral activity of the dietary supplement «Immuno-viral with vitamin C» against influenza A/Victoria virus strains

    Directory of Open Access Journals (Sweden)

    Ганна Сергіївна Шумова

    2016-01-01

    Full Text Available The implementation of combined remedies, having in their composition herbal material, that shows anti-inflammatory, antibacterial, antiviral, restorative, and immunotropic action, is one of promising directions in the search of effective agents for acute respiratory infections prevention and treatment.Aim. The purpose of our research was to determine antiviral activity of the dietary supplement «Immuno-viral with Vitamin C» in the form of hard capsules against influenza A/Victoria virus strains.Methods. Classic virological method of chick embryos contamination in the chorioallantoic membrane, immunofluorescence method for the obtained virus identification, and neutralization reaction in chick embryos has been used.Results. It has been determined that the dietary supplement components were non-toxic for chick embryos in dilution of 1:10 to 1:80; had antiviral activity against influenza A/Victoria prototype virus strain in dilution of 1:10 to 1:20; lethal toxic dose in dilution of 1:40. After administration of influenza A/Victoria prototype virus strain in chick embryos without incubation with the test remedy (passaging, the medicinal agent retained its initial properties, confirmed by infected embryo cells fluorescence and the further study of the subcultered strain in the inhibition hemagglutination test with chick erythrocytes.Conclusion. As a result of the carried out in experiment neutralization reaction in 9–11 days chick embryos by the method of contamination in the chorioallantoic membrane with further visualization and identification of material, containing the virus, by the immunofluorescence method of the infected cells specific fluorescence, antiviral properties of the dietary supplement «Immuno-viral with Vitamin C» components have been determined

  18. Caquexia cardíaca Cardiac cachexia

    Directory of Open Access Journals (Sweden)

    Alberto Miján

    2006-05-01

    Full Text Available La insuficiencia cardíaca de carácter crónico (ICC, en especial si afecta al corazón derecho, ocasiona con frecuencia malnutrición. Si esta es grave y se unen otros componentes, puede producirse caquexia cardíaca. Esta se asocia a mayor morbilidad y menor supervivencia de los pacientes que la padecen. Las causas de la caquexia cardíaca son diversas, en general asociadas a mantener balance energético negativo, surgiendo cada vez mayor evidencia que apoya un origen multifactorial de la misma. Entre otros, factores neurohormonales, inflamatorios, inmunológicos y metabólicos se superponen en el paciente con ICC, pudiendo producir afectación y deterioro de diversos órganos o sistemas, incluyendo la caquexia cardíaca. Esta puede definirse de diversos modos que, en general, concretan una reducción de peso en un tiempo definido o de estructuras corporales, ya que esta entidad afecta tanto a la masa magra o celular activa, como a los tejidos adiposo y óseo "osteoporosis. De todos ellos, el deterioro más acusado puede observarse en el tejido muscular esquelético, tanto a nivel estructural como funcional, no quedando exento el corazón de su afectación. Respecto del tratamiento, este debe basarse en la evidencia científica disponible. La valoración del estado nutricional de todo paciente con ICC es obligada, debiendo intervenir nutricionalmente ante MEP o riesgo de desarrollarla. En esta situación, mas si existe caquexia cardíaca, es necesaria una modificación de la dieta oral en energía y calidad de la misma, debiendo valorar la indicación de nutrición artificial específica complementaria o alternativa. Asimismo, cada vez adquiere mayor fuerza causal el papel beneficioso del ejercicio físico moderado, así como de la modulación por determinados fármacos de las alteraciones metabólicas e inflamatorias observadas en la caquexia cardíaca, que incluyen una respuesta favorable a nivel funcional y estructural del paciente con ICC

  19. Isolation and characterization of Bacillus subtilis CH16 strain from chicken gastrointestinal tracts for use as a feed supplement to promote weight gain in broilers.

    Science.gov (United States)

    Nguyen, A T V; Nguyen, D V; Tran, M T; Nguyen, L T; Nguyen, A H; Phan, T-N

    2015-06-01

    Spore-forming bacterial strains were isolated from chicken gastrointestinal tracts to develop a heat-stable feed supplement that promotes weight gain in broilers. Seven Bacillus strains having more than 90% sporulation were screened from the isolates and identified to be closely related with Bacillus subtilis and Bacillus licheniformis. Of the seven strains, B. subtilis CH16 was selected to develop a feed supplement for broilers, because it formed 100% heat-stable spores, grew rapidly at 42°C and quickly formed a biofilm. In large-scale trials in broilers (n ≥ 1150 per group), the group fed CH16 (3 × 10(6) CFU g(-1) pellet) showed higher average daily gain (ADG = 61·16) and lower food conversion ratio (FCR = 1·696) than did the group fed B. licheniformis CH22 (ADG = 57·10 and FCR = 1·792), the group fed B. subtilis HU58 (ADG = 51·90 and FCR = 1·868), BioPlus group (ADG = 59·32 and FCR = 1·807) and the control group (ADG = 56·02 and FCR = 1·880). In conclusion, CH16 spores significantly increased ADG by 9·17% and reduced FCR by 9·79% in broilers. The result supports the use of B. subtilis CH16 of chicken intestinal origin as a feed supplement that promote weight gain in broilers. Significance and impact of the study: This study reports screening of Bacillus strains isolated from chicken gastrointestinal tracts for development of a feed supplement that promote weight gain in broilers. Of the seven Bacillus isolates with high sporulation efficiency (≥90%), Bacillus subtilis CH16 strain showed the best growth and biofilm formation at body temperature of broilers (42°C). In large-scale trials in broilers (n ≥ 1150 per group), CH16 spores induced a 9·17% increase in daily weight gain (ADG) and a 9·79% reduction in FCR while the commercial BioPlus(®) YC induced only a 5·89% increase in ADG and a 3·88% reduction in FCR. © 2015 The Society for Applied Microbiology.

  20. 77 FR 65006 - Air Cargo Advance Screening (ACAS) Pilot Program

    Science.gov (United States)

    2012-10-24

    ... SECURITY U.S. Customs and Border Protection Air Cargo Advance Screening (ACAS) Pilot Program AGENCY: U.S...) pilot program which revises the time frame for transmission by pilot participants of a subset of... States for all other locations. The ACAS pilot is a voluntary test in which participants agree to submit...

  1. Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains

    Directory of Open Access Journals (Sweden)

    Abdullah U. Çatli

    2012-01-01

    Full Text Available One thousand two hundred 1-day-old Lohmann LSL white and Lohmann Brown layer chickens were fed diets supplemented with either an antibiotic growth promoter (AGP or an herbal essential oil mixture (EOM till 58 wk of age to reveal the long-term effects of those additives on growth, performance and wholesome egg quality parameters. The study was arranged in a 2x3 factorial design with two layer strains and three feed additive regimens. Thus, the layer birds of both strains were randomly assigned to the three dietary treatments, i.e., standard basal diet (control, control with AGP (specifically, avilamycin, 10 mg/kg diet and control with EOM (24 mg/kg diet. The data regarding egg production were recorded between 22 to 58 weeks of age. Neither the dietary treatments nor the bird strain influenced the body weight and mortality of the birds in both the growing and laying period. AGP or EOM supplementation to the laying hen diet significantly increased the egg production rate and egg weight as compared to the control  diet alone, but egg mass output, feed consumption, and feed conversion ratio were not effected  by the dietary treatments. Neither dietary treatment created any statistically significantly differences in egg quality parameters with the exception of Haugh unit. The research findings have confirmed the beneficial effects of supplementation with feed-grade EOM on the laying rate and egg weight of both white and brown layers. Indeed, EOM, being a novel feed additive natural origin, proved to be as efficacious as AGP in promoting egg yield.

  2. Disritmias cardíacas e anestesia

    Directory of Open Access Journals (Sweden)

    Michelle Nacur Lorentz

    2011-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As disritmias são complicações relativamente comuns no período perioperatório, devendo ser diagnosticadas e adequadamente tratadas pelo anestesiologista quando houver indicação para tal. Este artigo foi elaborado com o objetivo de revisar os aspectos mais relevantes das disritmias cardíacas para o anestesiologista, bem como estabelecer relação de causa e efeito entre os fármacos utilizados no período perioperatório e as disritmias. CONTEÚDO: São apresentados neste artigo os mecanismos das disritmias, os fármacos que potencialmente causam disritmias, além do diagnóstico e tratamento no período perioperatório. CONCLUSÕES: As disritmias que ocorrem no período perioperatório muitas vezes não demandam tratamento e, em outras tantas, o tratamento pode gerar uma verdadeira iatrogenia. Portanto, o conhecimento das disritmias cardíacas e dos fatores que podem desencadeá-las possibilita ao anestesiologista melhor abordagem perioperatória, evitando tratamentos equivocados ou desnecessários.

  3. Growth and productivity of different Pleuritus ostreatus strains on sunflower seed hulls supplemented with N-NH{sub 4}{sup +} and/or Mn(II)

    Energy Technology Data Exchange (ETDEWEB)

    Curvetto, N.R.; Figlas, D.; Devalis, R.; Delmastro, S. [Universidad Nacional del Sur, Buenos Aires (Argentina). Departamento de Agronomia

    2002-09-01

    The mycelial growth rates in lineal growth assay, yield, and production rate of five Pleurotus ostreatus strains were evaluated in response to different levels of Mn(II) and/or NH{sub 4}{sup +} in a substrate containing sunflower seed hulls as a main energy and nutritional component. Each strain showed different basal values for mycelial growth rate and biological efficiency on sunflower seed-hull substrate. Adding growth limiting mineral nutrients increased the mycelial growth rate by 13-25%. Primordia initiation for the first flush appeared between day 24 and 28 and days to the second crop ranged from 39 to 51. Biological efficiency increased over control values and reached 60-112%, depending on the strain and the concentration of Mn(II) and NH{sub 4}{sup +}. This study demonstrated the advantage of selecting the most productive P. ostreatus strains in a substrate formulated with sunflower seed hulls to provide the main energy and nutritional ingredients and supplemented with Mn(II) and/or NH{sub 4}{sup +}. (author)

  4. Growth and productivity of different Pleurotus ostreatus strains on sunflower seed hulls supplemented with N-NH4+ and/or Mn(II).

    Science.gov (United States)

    Curvetto, N R; Figlas, D; Devalis, R; Delmastro, S

    2002-09-01

    The mycelial growth rates in lineal growth assay, yield, and production rate of five Pleurotus ostreatus strains were evaluated in response to different levels of Mn(II) and/or NH4+ in a substrate containing sunflower seed hulls as a main energy and nutritional component. Each strain showed different basal values for mycelial growth rate and biological efficiency on sunflower seed-hull substrate. Adding growth limiting mineral nutrients increased the mycelial growth rate by 13-25%. Primordia initiation for the first flush appeared between day 24 and 28 and days to the second crop ranged from 39 to 51. Biological efficiency increased over control values and reached 60-112%, depending on the strain and the concentration of Mn(II) and NH4+. This study demonstrated the advantage of selecting the most productive P. ostreatus strains in a substrate formulated with sunflower seed hulls to provide the main energy and nutritional ingredients and supplemented with Mn(II) and/or NH4+.

  5. Effect of dietary folic acid supplementation on egg folate content and the performance and folate status of two strains of laying hens.

    Science.gov (United States)

    Hebert, K; House, J D; Guenter, W

    2005-10-01

    Enrichment of eggs with folate is possible when dietary folic acid levels are increased. However, development of optimal strategies for the production of folate-enriched eggs requires knowledge as to differences due to strain of bird and a greater understanding of the factors limiting egg folate deposition. To this end, a study was designed to determine the response of two leghorn strains that differ in production performance. Hyline W36 and W98 hens (n = 6 per diet) received a barley-based ration containing 0, 2, 4, 8, 16, 32, 64, or 128 mg/kg of crystalline folic acid for 21 d. Response criteria included production parameters, measures of blood folate status, and egg folate content. Significant (P folic acid through a reduction in plasma homocysteine concentrations, suggesting that this strain has a higher requirement for folate than the W36 strain. Overall, egg folate content is maximized when crystalline folic acid is supplemented to the diet at 2 mg/kg or higher. Higher levels of egg folate are not achieved due to the saturation of the precursor pool for egg folate deposition.

  6. Development of stress tolerant Saccharomyces cerevisiae strains by metabolic engineering: New aspects from cell flocculation and zinc supplementation.

    Science.gov (United States)

    Cheng, Cheng; Zhang, Mingming; Xue, Chuang; Bai, Fengwu; Zhao, Xinqing

    2017-02-01

    Budding yeast Saccharomyces cerevisiae is widely studied for the production of biofuels from lignocellulosic biomass. However, economic production is currently challenged by the repression of cell growth and compromised fermentation performance of S. cerevisiae strains in the presence of various environmental stresses, including toxic level of final products, inhibitory compounds released from the pretreatment of cellulosic feedstocks, high temperature, and so on. Therefore, it is important to improve stress tolerance of S. cerevisiae to these stressful conditions to achieve efficient and economic production. In this review, the latest advances on development of stress tolerant S. cerevisiae strains are summarized, with the emphasis on the impact of cell flocculation and zinc addition. It was found that cell flocculation affected ethanol tolerance and acetic acid tolerance of S. cerevisiae, and addition of zinc to a suitable level improved stress tolerance of yeast cells to ethanol, high temperature and acetic acid. Further studies on the underlying mechanisms by which cell flocculation and zinc status affect stress tolerance will not only enrich our knowledge on stress response and tolerance mechanisms of S. cerevisiae, but also provide novel metabolic engineering strategies to develop robust yeast strains for biofuels production. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  7. Pigs experimentally infected with an enterotoxigenic strain of Escherichia coli have improved feed efficiency and indicators of inflammation with dietary supplementation of tryptophan and methionine in the immediate post-weaning period

    DEFF Research Database (Denmark)

    Capozzalo, Meeka M; Kim, Jae Cheol; Htoo, J.K.

    2016-01-01

    This experiment tested the hypothesis that pigs challenged with an enterotoxigenic strain of E. coli (ETEC) will improve performance by dietary supplementation of sulfur amino acids (SAA) and tryptophan (Trp) above the current recommended levels in the immediate post-weaning period. Male pigs (n ...

  8. Effects of Supplemental Dietary Phytase and 25-Hydroxycholecalciferol on the Performance Characteristics of Commercial Layers Inoculated before or at the Onset of Lay with the F-Strain of Mycoplasma gallisepticum

    Science.gov (United States)

    The effects of dietary supplementation with phytase and 25-hydroxycholecalciferol on the performance characteristics of commercial layers that were inoculated prelay (12 wk of age) or at the onset of lay (22 wk of age) with F-strain Mycoplasma gallisepticum were assessed. Experimental layer diets, w...

  9. Influence of supplemental dietary poultry fat, phytase, and 25-hydroxycholecalciferol on the egg characteristics of commercial layers inoculated before or at the onset of lay with F-strain Mycoplasma gallisepticum

    Science.gov (United States)

    The effects of 2 supplemental levels of dietary poultry fat (PF) and the combination of PF, phytase (PHY) and 25-hydroxycholecalciferol (D3) on the egg characteristics of commercial layers inoculated with F-strain Mycoplasma gallisepticum (FMG) were investigated in 2 trials. Sham and FMG inoculatio...

  10. Influence of Supplemental Dietary Poultry Fat, Phytase, and 25-Hydroxycholecalciferol on the Performance of Commercial Layers Inoculated Before or at the Onset of Lay with F-Strain Mycoplasma gallisepticum

    Science.gov (United States)

    The effects of 2 levels of supplemental dietary poultry fat (PF) and the combination of PF, phytase (PHY) and 25-hydroxycholecalciferol (D3) on the performance of commercial layers inoculated with F-strain Mycoplasma gallisepticum (FMG) were investigated in 2 trials. Sham and FMG inoculations were ...

  11. Influence of supplemental dietary poultry fat, phytase, and 25-hydroxycholecalciferol on the blood characteristics of commercial layers inoculated before or at the onset of lay with F-strain Mycoplasma gallisepticum

    Science.gov (United States)

    The effects of 2 supplemental levels of dietary poultry fat (PF) and the combination of PF, phytase (PHY) and 25-hydroxycholecalciferol [25(OH)D] on the blood characteristics of commercial layers inoculated with F-strain Mycoplasma gallisepticum (FMG) were investigated in 2 trials. Sham and FMG ino...

  12. Anaerobic Production of Hydrogen in the Dark by Synechocystis sp. strain PCC 6803 supplemented with D-glucose

    Directory of Open Access Journals (Sweden)

    Takashi Yamamoto

    2012-08-01

    Full Text Available The effect of D-glucose on the anaerobic production of hydrogen (H2 in the dark by bidirectional hydrogenase of Synechocystis sp. strain PCC 6803 has been studied. D-glucose addition enhanced H2 production rate. It is deduced that NAD(PH, which is a substrate of H2 production reaction, was supplied by catabolism of D-glucose. The molar consumption ratio of H2 and total sugar consumption was low in the presence of D-glucose due to production of L-lactic acid and other metabolites. The cells photosynthetically grown in air produced lower H2 in the dark as compared with those grown in air with 6% CO2, but the lower H2 production was compensated with the addition of D-glucose at 6.4 times of control value without D-glucose. The trend of effect of pH in a growth medium and a reaction mixture on H2 production was not affected by the presence of D-glucose. This result implies that mechanisms of H2 productions with and without D-glucose are similar.

  13. 75 FR 56578 - Renewal of the Advisory Committee on Apprenticeship (ACA), and an Open Meeting

    Science.gov (United States)

    2010-09-16

    ... Members Overview of the Administration's Priorities and Expectation of the ACA Selection of the ACA Co..., Executive Director, Association for Career and Technical Education, Alexandria, Virginia. Mr. Andrew Cort...

  14. Insuficiencia cardíaca congestiva o cor pulmonale

    OpenAIRE

    Amarís Peña, Óscar Ernesto

    2014-01-01

    La insuficiencia cardíaca es una de las principalescausas de muerte cardiovascular y se presentacomo consecuencia, en más del 70 porciento de los casos, de las dos enfermedadescardiovasculares de mayor prevalencia: lahipertensión arterial y la enfermedad coronaria.La disnea y el edema en los miembros inferioresson los dos criterios más usados para el diagnósticode insuficiencia cardíaca congestiva yestos son, justamente, las principales manifestacionesde los pacientes con Cor Pulmonale.Este d...

  15. Effects of dietary supplementation with sage (Salvia officinalis L.) essential oil on antioxidant status and duodenal wall integrity of laying strain growers.

    Science.gov (United States)

    Placha, I; Ryzner, M; Cobanova, K; Faixova, Z; Faix, S

    2015-01-01

    The objective of this study was to compare the influence of four different concentrations of Salvia officinalis essential oil (EO) on animal health. A total of 50 laying strain chicks were randomly divided at the day of hatching into five dietary-treatment groups. Control group was given the basal diet (BD), the other four experimental groups contained BD supplemented with 0.1, 0.25, 0.5, 1.0 g S. officinalis EO/kg diet, respectively. 0.1 g/kg EO increased glutathion peroxidase activity (GPx) in duodenal mucosa, liver and kidney, phagocytic activity in blood (PA), transepithelial electrical resistance (TEER) in duodenal tissue and decreased malondialdehyde (MDA) concentration in plasma and liver. 0.25 g/kg EO increased GPx in liver, total antioxidant status (TAS) in plasma, PA in blood and TEER in duodenal tissue. Our results demonstrate that lower concentrations of EO improve animals' health status, and that it is necessary keep in mind the selection of sufficient concentration of EO used as animal feed additive.

  16. 77 FR 65395 - Air Cargo Advance Screening (ACAS) Pilot Program

    Science.gov (United States)

    2012-10-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Air Cargo Advance Screening (ACAS) Pilot Program Correction In notice document 2012-26031 appearing on pages 65006-65009 in the issue of October 24, 2012 make...

  17. Framing, Engagement, and Policy Change: Lessons for the ACA.

    Science.gov (United States)

    Karch, Andrew; Rosenthal, Aaron

    2017-04-01

    Supporters of the Patient Protection and Affordable Care Act (ACA) sometimes speculate that public attitudes toward the law will shift if proponents succeed in focusing attention on its more popular components, but the scholarly literature on framing effects provides ample reason to question their assertion. This article contends that engagement, an alternative rhetorical strategy where advocates address the same policy dimensions as their opponents, is a more promising approach. Extending the engagement literature to the elite context in which most ACA-related decisions are made, it argues that elite-level engagement necessitates the additional task of linking policy change to opponents' broader philosophical and policy goals. Current debates surrounding the application of sales taxes to electronic commerce-a policy arena that seems far removed from health care policy but overlaps with the ACA in ways that make it an appropriate source of lesson drawing-illustrate the potential of an engagement strategy. Recently, many conservative lawmakers who previously opposed policy change have instead embraced online sales taxes as a mechanism for additional tax cuts. Analogous connections may facilitate the diffusion of ACA provisions that presently receive hostile receptions in Republican-leaning states.

  18. Testing the ACA Phase Correction Scheme using the SMA

    CERN Document Server

    Matsushita, Satoki

    2010-01-01

    We conducted the observational tests of a phase correction scheme for the Atacama Compact Array (ACA) of the Atacama Large Millimeter and submillimeter Array (ALMA) using the Submillimeter Array (SMA). Interferometers at millimeter- and submillimeter-wave are highly affected by the refraction induced by water vapor in the troposphere, which results as phase fluctuations. The ACA is planning to compensate the atmospheric phase fluctuations using the phase information of the outermost antennas with interpolating to the inner antennas by creating a phase screen. The interpolation and extrapolation phase correction schemes using phase screens are tested with the SMA to study how effective these schemes are. We produce a plane of a wavefront (phase screen) from the phase information of three antennas for each integration, and this phase screen is used for the interpolation and extrapolation of the phases of inner and outer antennas, respectively. The interpolation scheme obtains apparently improved results, sugges...

  19. Impact of ACA on the Dinner-for-Three Dynamic.

    Science.gov (United States)

    Schoonveld, Ed; Coyle, Bill; Markham, Jennifer

    2015-04-01

    The Patient Protection and Affordable Care Act (ACA) aims to expand coverage to the previously uninsured, improve the quality of coverage, and help eliminate inefficiencies in the health care market. We evaluated the implications of ACA on the drug industry by examining the impact on the "Dinner-for-Three" dynamic in our health care system. We can think of our system as an odd dinner party in which one person pays (the insurer), one orders the meal (the physician), and yet another eats the meal (the patient). This dynamic requires us to examine each stakeholder and how they interact with one another to assess the impact of the ACA. Of the 6.7 million initial exchange enrollees, ~3.8 million subjects were previously uninsured. A higher percentage of these enrollees are using their pharmacy benefit, and they are disproportionately filling prescriptions for specialty drugs relative to those covered in employer-sponsored plans. Formulary designs in exchange plans are passing on higher cost-sharing for prescription drugs to the patient. ACA has also resulted in the development of accountable care organizations (ACOs); these organizations may play a role going forward in the management of drug spending and the development of formularies and protocols that impact drug prescribing. Payers are tightening control over drug spending and are finding physicians and physician groups increasingly less reluctant allies in doing so. Patients are faced by more complexity than ever in the health care system and are expected to take a more active role in responsibly managing the cost of their care. It is increasingly critical that drug manufacturers develop robust value propositions and communicate that value to all stakeholders. They should re-evaluate trial investment decisions and consider changes in price setting, rebates (how much and to whom), copay programs, and physician and patient support programs in light of changing market needs. Copyright © 2015 The Authors. Published by

  20. Dietary Supplements

    Science.gov (United States)

    Dietary supplements are vitamins, minerals, herbs, and many other products. They can come as pills, capsules, powders, drinks, and energy bars. Supplements do not have to go through the testing that drugs do. Some supplements ...

  1. ACA and the Triple Aim: Musings of a Health Care Actuary.

    Science.gov (United States)

    McCarthy, Mac

    2015-01-01

    In 2008, the Institute for Healthcare Improvement (IHI) promulgated the Triple Aim, which advocates simultaneous improvements in patient experiences, improved population health and lower cost per capita. In 2010, the Patient Protection and Affordable Care Act (ACA) promised quality, affordable health care for all Americans. It's fair to assume that the framers of ACA were aware of the Triple Aim, and it is likely that much of ACA was heavily influenced by IHI's positions. So it is reasonable, from time to time, to assess ACA's impact on health care against the Triple Aim principles.

  2. Macedovicin, the second food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198.

    Science.gov (United States)

    Georgalaki, Marina; Papadimitriou, Konstantinos; Anastasiou, Rania; Pot, Bruno; Van Driessche, Gonzalez; Devreese, Bart; Tsakalidou, Effie

    2013-02-01

    Streptococcus macedonicus ACA-DC 198 was found to produce a second lantibiotic named macedovicin in addition to macedocin. Macedovicin was purified to homogeneity and mass spectrometric analysis identified a peptide of approximately 3.4 kDa. Partial N-terminal sequence analysis and tandem mass spectrometry revealed that macedovicin was identical to bovicin HJ50 and thermophilin 1277 produced by Streptococcus bovis and Streptococcus thermophilus, respectively. Macedovicin inhibits a broad spectrum of lactic acid bacteria, several food spoilage species (e.g. Clostridium spp.) and oral streptococci. We determined the complete biosynthetic gene cluster of macedovicin. Even though the gene clusters of macedovicin, thermophilin 1277 and bovicin HJ50 were almost identical at the nucleotide level, there were important differences in their predicted genes and proteins. Bovicin HJ50-like lantibiotics were also found to be encoded by Streptococcus suis strains SC84 and D12, Enterococcus columbae PLCH2, Clostridium perfringens JGS1721 and several Bacillus strains. All these lantibiotics contained a number of conserved amino acids that may be important for their biosynthesis and activity, while phylogenetic analysis supported their dispersion by horizontal gene transfer. In conclusion, the production of multiple bacteriocins may enhance the bio-protective potential of S. macedonicus during food fermentation.

  3. A Critical Examination of the Assessment Analysis Capabilities of OCLC ACAS

    Science.gov (United States)

    Lyons, Lucy E.

    2005-01-01

    Over 500 libraries have employed OCLC's iCAS and its successor Automated Collection Assessment and Analysis Services (ACAS) as bibliometric tools to evaluate monograph collections. This examination of ACAS reveals both its methodological limitations and its feasibility as an indicator of collecting patterns. The results can be used to maximize the…

  4. 76 FR 20352 - Notice of Intent To Award Affordable Care Act (ACA) Funding

    Science.gov (United States)

    2011-04-12

    ... HUMAN SERVICES Centers for Disease Control and Prevention Notice of Intent To Award Affordable Care Act (ACA) Funding Notice of Intent to award Affordable Care Act (ACA) funding to two Emerging Infections... participating EIP sites. Funding is appropriated under the Affordable Care Act (PL 111-148), Title IV,...

  5. Defining the Field: Revisiting the ACA 1995 Definition of Communication Studies.

    Science.gov (United States)

    Korn, Charles J.; Morreale, Sherwyn P.; Boileau, Don M.

    2000-01-01

    Presents results of a survey of Association for Communication Administration (ACA) members concerning their awareness and use of the 1995 ACA Definition of the Field of Communication. Finds that 40% of administrators who responded were unaware of the definition. Urges the need to further promote the definition of the field. (NH)

  6. Caquexia associada à insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Marina Politi Okoshi

    2013-05-01

    Full Text Available Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e alteração da relação entre processos anabólicos e catabólicos. Como não há terapia específica para a caquexia associada à insuficiência cardíaca, o tratamento baseia-se no suporte nutricional, bloqueio neuro-hormonal, controle do edema e anemia e exercícios físicos. Fármacos com propriedades imunomodulatórias e anabólicas encontram-se em investigação clínica e experimental.

  7. Senate Republican leadership releases revised ACA repeal and replace bill

    Directory of Open Access Journals (Sweden)

    Moore NS

    2017-07-01

    Full Text Available No abstract available. Article truncated after first 150 words. Today, the Senate Republican leadership released a revised version of a bill to repeal and replace the Affordable Care Act (ACA. The new bill draft includes an amendment sponsored by Sen. Cruz (R-TX that permits insurers to offer health insurance plans on the ACA exchanges that do not cover the ACA’s 10 essential health benefits (EHB as long as they offer at least one other plan that provides full coverage of EHB’s. The bill also includes more funding for opioid addiction and for state initiatives to reduce insurance premiums and additionally, some flexibility for state Medicaid funding in the event of a public health crisis. The bill must still receive a cost estimate from the Congressional Budget Office (CBO, which will include the impact of the bill on insurance coverage levels, expected out Monday. The ATS remains deeply concerned about the bill because under the Cruz proposal, insurance coverage costs …

  8. Expression and intracellular localization of ACA and TRA-1-81 in smooth muscle cell tumors.

    Science.gov (United States)

    Sukhikh, G T; Becker-Kojić, Z; Kogan, E A; Demura, T A; Faizullina, N M; Nizyaeva, N V; Schott, A; Ureña-Peralta, J J; Askol'skaya, S I; Popov, Yu V

    2013-08-01

    We studied the expression and intracellular localization of ACA and TRA-1-81 in smooth muscle cell tumors. The study was performed on tissue specimens obtained during surgery from patients with uterine leiomyoma and leiomyosarcoma (mean age 34 and 51 years, respectively). ACA was present in leiomyoma, leiomyosarcoma, and control myometrium. Intracellular expression of ACA varied in different types of tumors and was minimum in normal myometrium and maximum in leiomyosarcoma. Membrane localization of the protein is typical of common and cellular leiomyoma, while in the growth zones of mitotically active leiomyoma and leiomyosarcoma the reaction product was primarily located in tumor cell cytoplasm. TRA was detected in some leiomyosarcoma cells. Thus, ACA dysregulation was revealed in the growth zones of leiomyomas and in leiomyosarcomas, which manifested in enhanced expression of this protein and its detachment from the plasma membrane, which leads ACA translocation into the cytoplasm and nucleus of tumor cells and potentiates their proliferative activity.

  9. 76 FR 41263 - Notice of Intent To Award Affordable Care Act (ACA) Funding, EH10-1004

    Science.gov (United States)

    2011-07-13

    ... health and help restrain the rate of growth in private and public sector health care costs.'' ACA and the... (ACA) Funding, EH10-1004 Notice of Intent to award Affordable Care Act (ACA) funding to National Association for Public Health Statistics and Information Systems (NAPHSIS) to continue with the...

  10. Signature of MoU between CERN and Australian Collaboration for Accelerator Science (ACAS); Roger Rassool, ACAS Director; Mark Boland, ACAS Deputy Director; Jean-Pierre Delahaye, CLIC Project Leader; in the presence of Rolf Heuer, Director-General and Emmanuel Tsesmelis, Adviser for Australia

    CERN Document Server

    Maximilien Brice

    2010-01-01

    Signature of MoU between CERN and Australian Collaboration for Accelerator Science (ACAS); Roger Rassool, ACAS Director; Mark Boland, ACAS Deputy Director; Jean-Pierre Delahaye, CLIC Project Leader; in the presence of Rolf Heuer, Director-General and Emmanuel Tsesmelis, Adviser for Australia

  11. The Benefit Aftereffects of ACA--Accelerating Toward a New Health Economy.

    Science.gov (United States)

    Mansur, Greg; Thompson, Michael

    2015-01-01

    While the Affordable Care Act (ACA) focused largely on improving access to health care coverage for the uninsured, its broader and longer-term influence may have been its impact on accelerating key trends and strategies that major employers and other stakeholders have been targeting for years. This article looks at some of these trends, where we were pre-ACA and how ACA (through benefit mandates, shared responsibility penalties, Cadillac plan tax, health information technology, accountable care organizations, etc.) has helped to accelerate and refocus efforts. In addition, the public exchange paradigm has given rise to a private exchange movement that is helping further accelerate the transformation of the New Health Economy.

  12. Albumin activation of urinary amylase as determined with the Du Pont aca.

    Science.gov (United States)

    Garber, C C; Carey, R N

    1978-04-01

    Protein activation of urinary alpha-amylase (EC 3.2.1.1) activity was observed during an evaluation of the Du Pont aca procedure for the determination of urinary alpha-amylase. This activation effect became constant for urinary albumin concentrations exceeding 1.50 g/liter. It is recommended that urinary alpha-amylase be analyzed with sufficient albumin added to maximize this effect. The aca alpha-amylase procedure is compared to an amyloclastic method for both serum and urine analysis. Expected ranges are presented for the aca method for serum and urinary amylase, amylase clearance, and the amylase clearance/creatinine clearance ratio.

  13. Effects of different media supplements on the production of an active recombinant plant peroxidase in a Pichia pastoris Δoch1 strain

    OpenAIRE

    Gmeiner, Christoph; Spadiut, Oliver

    2015-01-01

    Recombinant protein production in microorganisms is one of the most studied areas of research in biotechnology today. In this respect the yeast Pichia pastoris is an important microbial production host due to its capability of secreting the target protein and performing posttranslational modifications. In a recent study, we described the development of a robust bioprocess for a glyco-engineered recombinant P. pastoris strain where the native α-1,6-mannosyltransfrease OCH1 was knocked out (Δoc...

  14. Receptores beta adrenérgicos e insuficiencia cardíaca

    National Research Council Canada - National Science Library

    Tacchi, Héctor H

    2008-01-01

    La insuficiencia cardíaca es una de las enfermedades más incapacitantes y que provocan mayor cantidad de muertes en la sociedad, a esto hay que agregarle el importante costo social que ello trae aparejado...

  15. Toward a conceptual understanding of acute cultural adaptation: A preliminary examination of ACA in female swimming

    DEFF Research Database (Denmark)

    Ryba, Tatiana; Haapanen, Saara; Mosek, Shwiko

    2012-01-01

    This paper considers a novel approach to researching adaptation in transnational athletes. The first part introduces a conceptualisation of acute cultural adaptation (ACA), which extends the current literature in sport psychology by offering original insights into mechanisms underpinning adaptive...

  16. Supplemental Colleges

    Data.gov (United States)

    Department of Homeland Security — The Supplemental Colleges layer attempts to capture additional Post Secondary Education campuses of colleges and universities associated with a single campus listed...

  17. Regeneración celular cardíaca

    Directory of Open Access Journals (Sweden)

    Jesús Herreros

    2011-07-01

    Full Text Available La terapia celular con células madre, como estrategia para regenerar tejidos dañados, es una de las áreas más prometedoras en el tratamiento de enfermedades con escasas o nulas expectativas de curación. La insuficiencia cardíaca, principalmente de origen isquémico, es una de las enfermedades que más se pueden beneficiar de esta estrategia. El objetivo es regenerar el músculo, reducir la apoptosis, aumentar la expresión del colágeno intersticial e inducir la generación de nuevos vasos. la terapia celular cardíaca ha sido propuesta con una gran variedad de células angiogénicas y miogénicas: mioblastos esqueléticos, células mononucleares y mesenquimales de médula ósea, progenitores endoteliales circulantes, células derivadas del estroma de la grasa o del endometrio, células mesoteliales y pluripotenciales (induced pluripotent stem cells [iPS]. las indicaciones incluyen a pacientes con miocardiopatía isquémica o dilatada, enfermedad de Chagas, insuficiencia mitral isquémica y miocardiopatía diabética. Los abordajes son quirúrgicos, con inyección periinfarto, intracoronario y endoventricular percutáneo. Los mecanismos de acción propuestos son la reducción del tamaño de la cicatriz del infarto, el aumento de la viabilidad miocárdica, la limitación del remodelado ventricular y los efectos paracrinos. Sin embargo, los resultados clínicos muestran sólo mejoras muy limitadas de la función sistólica y del remodelado ventricular. El desarrollo de estrategias que mejoren la supervivencia y la diferenciación celular deben ser prioritarias, tales como el preacondicionamiento con electroestimulación o la ingeniería tisular con el objetivo de desarrollar un miocardio bioartificial.

  18. Sports Supplements

    Science.gov (United States)

    ... not getting the whole story about how supplements work, if they are really effective, and the risks you take by using them. Androstenedione and DHEA ... like testicular cancer, infertility, stroke, and an increased risk of heart ... height. Natural steroid supplements can also cause breast development ...

  19. Tratamento nutricional em pacientes com insuficiência cardíaca Nutritional treatment for heart failure patients

    Directory of Open Access Journals (Sweden)

    Viviane Sahade

    2009-06-01

    Full Text Available A insuficiência cardíaca é um problema grave e crescente de saúde pública em todo o mundo, sendo a via final comum da maioria das cardiopatias. Apesar dos recentes avanços da medicina, pouca atenção vem sendo dada ao tratamento não farmacológico, em particular à terapia nutricional. A evolução clínica dos pacientes com insuficiência cardíaca, via de regra, caminha para quadros variáveis de desnutrição, de causa multifatorial e que não está necessariamente relacionada ao índice de massa corporal. Assim, o objetivo deste trabalho foi revisar a literatura na busca por evidências sobre a composição adequada da dieta no tratamento de pacientes com insuficiência cardíaca. Realizou-se uma revisão sistemática nas bases de dados Medline, Pubmed, Lilacs, SciELO e dos comitês nacionais e internacionais de saúde, dos artigos publicados no período compreendido entre 1981 e 2006. Observou-se que existem poucos estudos bem elaborados, sobre a adequação da dietoterapia na insuficiência cardíaca e que esta ainda é muito restrita ao controle do sal e de líquido, sendo dada pouca atenção à quantidade e à qualidade dos demais nutrientes. Existe uma crescente evidência de que a dieta é um fator importante no prognóstico e no tratamento desses pacientes, porém futuros estudos, incluindo ensaios clínicos com adequado número de participantes, se fazem necessários para que se possa prescrever, com segurança, suplementos nutricionais.Heart failure is a serious and increasing public health problem around the world, and is the common endpoint of most heart diseases. Despite recent medical advances, little attention has been given to the non-pharmacological treatments, specifically, to nutritional therapy. The clinical course of patients with heart failure constantly progresses to varying degrees of malnutrition caused by different factors and not necessarily related to body mass index. Thus, the objective of this study was

  20. Sensibilidade do eletrocardiograma na hipertrofia ventricular de acordo com gênero e massa cardíaca

    Directory of Open Access Journals (Sweden)

    Ana P. Colossimo

    2011-09-01

    Full Text Available FUNDAMENTO: Sabe-se que vários fatores interferem na sensibilidade do Eletrocardiograma (ECG no diagnóstico da Hipertrofia Ventricular Esquerda (HVE, sendo o gênero e a massa cardíaca alguns dos principais. OBJETIVO: Avaliar a influência do sexo na sensibilidade de alguns dos critérios utilizados para a detecção de HVE, de acordo com a progressão do grau de hipertrofia ventricular. MÉTODOS: De acordo com o gênero e com o grau de HVE ao ecocardiograma, os pacientes foram divididos em três grupos: HVE leve, moderada e severa. Avaliou-se a sensibilidade do ECG para detectar HVE entre homens e mulheres, conforme o grau de HVE. RESULTADOS: Dos 874 pacientes, 265 eram homens (30,3% e 609, mulheres (69,7%. Os critérios [(S + R X QRS], Sokolow-Lyon, Romhilt-Estes, Perúgia e padrão strain mostraram alto poder discriminatório no diagnóstico de HVE entre homens e mulheres nos três grupos de HVE, com desempenho superior na população masculina e destaque para os escores [(S + R X QRS] e Perúgia. CONCLUSÃO: A sensibilidade diagnóstica do ECG é maior com o aumento da massa cardíaca. O exame é mais sensível entre homens, destacando-se os escores [(S + R X QRS] e Perúgia.

  1. Supplemental information

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supplemental information showing results of inter-comparison between C-PORT, AERMOD and R-LINE dispersion algorithms. This dataset is associated with the following...

  2. Nutritional supplements

    DEFF Research Database (Denmark)

    Petersen, Gry Bjerg; Andersen, Jens Rikardt

    2015-01-01

    Background: Several studies have indicated that cancer patients have significantly altered taste sensitivity without specifying the preferences. One of the related problems is low compliance to nutritional therapy with oral nutritional supplements (ONS) in patients suffering severe weight loss...

  3. First impressions: geographic variation in media messages during the first phase of ACA implementation.

    Science.gov (United States)

    Gollust, Sarah E; Barry, Colleen L; Niederdeppe, Jeff; Baum, Laura; Fowler, Erika Franklin

    2014-12-01

    Many Americans will learn about the implementation of the Patient Protection and Affordable Care Act (ACA) through the mass media. We examined geographic variation in the volume and content of mass media during the initial two-week rollout of the new health insurance marketplaces in October 2013 across 210 US media markets, using data from the Wesleyan Media Project. We found substantial geographic variation in the volume and tone of insurance product advertisements, political advertisements, and news coverage of the ACA marketplaces. News coverage of the ACA airing in media markets located in states operating federal or partnership marketplaces was more negative than coverage airing in markets located in states running their own marketplaces. Intrastate variation in media volume and content was also substantial and appears distinguishable from the local political climate. Variation in exposure to media messages likely affects public sentiment regarding the ACA and could contribute to geographic differences in insurance enrollment and public perceptions of US health care options. Researchers and policy makers evaluating the implementation of the ACA-and insurance enrollment in the marketplaces in particular-should consider addressing media influences.

  4. Promoting Value for Consumers: Comparing Individual Health Insurance Markets Inside and Outside the ACA's Exchanges.

    Science.gov (United States)

    McCue, Michael J; Hall, Mark A

    2016-06-01

    The new health insurance exchanges are the core of the Affordable Care Act's (ACA) insurance reforms, but insurance markets beyond the exchanges also are affected by the reforms. This issue brief compares the markets for individual coverage on and off of the exchanges, using insurers' most recent projections for ACA-compliant policies. In 2016, insurers expect that less than one-fifth of ACA-compliant coverage will be sold outside of the exchanges. Insurers that sell mostly through exchanges devote a greater portion of their premium dollars to medical care than do insurers selling only off of the exchanges, because exchange insurers project lower administrative costs and lower profit margins. Premium increases on exchange plans are less than those for off-exchange plans, in large part because exchange enrollment is projected to shift to closed-network plans. Finally, initial concerns that insurers might seek to segregate higher-risk subscribers on the exchanges have not been realized.

  5. Estimating the Counterfactual: How Many Uninsured Adults Would There Be Today Without the ACA?

    Science.gov (United States)

    Blumberg, Linda J; Garrett, Bowen; Holahan, John

    2016-01-01

    Time lags in receiving data from long-standing, large federal surveys complicate real-time estimation of the coverage effects of full Affordable Care Act (ACA) implementation. Fast-turnaround household surveys fill some of the void in data on recent changes to insurance coverage, but they lack the historical data that allow analysts to account for trends that predate the ACA, economic fluctuations, and earlier public program expansions when predicting how many people would be uninsured without comprehensive health care reform. Using data from the Current Population Survey (CPS) from 2000 to 2012 and the Health Reform Monitoring Survey (HRMS) data for 2013 and 2015, this article develops an approach to estimate the number of people who would be uninsured in the absence of the ACA and isolates the change in coverage as of March 2015 that can be attributed to the ACA. We produce counterfactual forecasts of the number of uninsured absent the ACA for 9 age-income groups and compare these estimates with 2015 estimates based on HRMS relative coverage changes applied to CPS-based population estimates. As of March 2015, we find the ACA has reduced the number of uninsured adults by 18.1 million compared with the number who would have been uninsured at that time had the law not been implemented. That decline represents a 46% reduction in the number of nonelderly adults without insurance. The approach developed here can be applied to other federal data and timely surveys to provide a range of estimates of the overall effects of reform.

  6. Cardiopatias congênitas e malformações extracardíacas

    Directory of Open Access Journals (Sweden)

    Rosana Cardoso M. Rosa

    2013-06-01

    Full Text Available OBJETIVO: Revisar a associação entre cardiopatias congênitas e malformações extracardíacas. FONTES DE DADOS: A pesquisa incluiu artigos científicos presentes nos portais Medline, Lilacs e SciELO, utilizando-se os descritores "congenital heart disease", "congenital heart defects", "congenital cardiac malformations", "extracardiac defects" e "extracardiac malformations". Foram incluídos os artigos de séries de casos que exploravam especificamente a associação entre cardiopatias congênitas e malformações extracardíacas. SÍNTESE DOS DADOS: A cardiopatia congênita é responsável por cerca de 40% dos defeitos congênitos, sendo uma das malformações mais frequentes e a de maior morbimortalidade. Malformações extracardíacas são observadas em 7 a 50% dos pacientes com cardiopatia congênita, trazendo um risco ainda maior de comorbidade e mortalidade e tornando a cirurgia cardíaca mais arriscada. Diferentes estudos têm tentado avaliar a presença de anormalidades extracardíacas em pacientes portadores de cardiopatia congênita. Dentre as alterações descritas, destacam-se aquelas do trato urinário. Contudo, não houve um estudo que tenha avaliado do mesmo modo todos os pacientes. CONCLUSÕES: Anormalidades extracardíacas são frequentes em pacientes com cardiopatia congênita, sendo que os portadores de tais alterações podem apresentar um risco maior de morbimortalidade. Consequentemente, alguns autores vêm discutindo a importância e o custo-benefício da triagem destas crianças à procura de outras malformações por meio de exames complementares.

  7. 76 FR 59703 - Notice of Intent To Award Affordable Care Act (ACA) Funding, RFA-TP-08-001

    Science.gov (United States)

    2011-09-27

    ... HUMAN SERVICES Centers for Disease Control and Prevention Notice of Intent To Award Affordable Care Act... Affordable Care Act (ACA) funding to Preparedness and Emergency Response Research Centers (PERRCs). This... award Affordable Care Act (ACA) appropriations to the following 4 Preparedness and Emergency...

  8. Levosimendan: Nueva estrategia en el manejo de la falla cardíaca

    OpenAIRE

    González-Chon,Octavio; García López,Sandra María del Carmen; Chacón Mercado,Marco Alejandro; Arias Sánchez,Eduardo Agustín; Vega Zapata,Reyna Estela

    2005-01-01

    La insuficiencia cardíaca congestiva se ha considerado como un grave problema de salud. De manera tradicional, la insuficiencia cardíaca ha sido manejada con diferentes fármacos, como son los diuréticos, digital, inotrópicos del tipo de las catecolaminas y no catecolaminas; sin embargo, el manejo de los mismos, también tienen efectos secundarios en donde se incluyen la génesis de las arritmias e incluso la muerte. Un nuevo grupo de drogas recientemente ha impactado en el manejo de los pacient...

  9. Registro Nacional de Internación por Insuficiencia Cardíaca

    OpenAIRE

    Raúl Borracci; Fernando Botto; María Marturano; Susana Fernández; Javier Guetta; Patricia Blanco; Leandro Rodríguez; Enrique Fairman; Jorge Thierer; Consejo de Emergencias Cardiovasculares. Área de Investigación. Sociedad Argentina de Cardiología

    2009-01-01

    IntroducciónLa insuficiencia cardíaca representa una de las principales causas de internación con una tasa elevada de complicaciones y cuyo enfoque no parece que haya mejorado en los últimos años.ObjetivosConocer el perfil epidemiológico y clínico, analizar las medidas terapéuticas y la evolución durante la internación y a los 3 meses de pacientes admitidos por insuficiencia cardíaca descompensada.Material y métodosRegistro prospectivo, multicéntrico de pacientes internados por insuficiencia ...

  10. Insuficiència cardíaca i fallida renal : quan tot s'ajunta

    OpenAIRE

    Zamora, Elisabet

    2008-01-01

    Un dels problemes que coexisteixen amb la insuficiència cardíaca és la insuficiència renal. Els autors d'aquest article proposen un mètode alternatiu per poder detectar de manera més precisa la presència d'aquesta fallida renal en els pacients amb insuficiència cardíaca, ja que els mètodes habituals, basats únicament en la determinació de la creatinina en sang, són menys sensibles.

  11. ACA: Phoenix of-or Cooked in-This Dumpster Fire of an Election.

    Science.gov (United States)

    Kirkner, Richard Mark

    2016-10-01

    Hillary Clinton and Donald Trump promise divergent approaches to the ACA if elected. Basically, Clinton wants to improve it; Trump promises to dismantle it. Of course, no president acts in a vacuum, and a lot will also depend on which party controls Congress.

  12. 76 FR 5404 - Notice of Renewal of the Advisory Committee on Apprenticeship (ACA) Charter

    Science.gov (United States)

    2011-01-31

    ... revisions are intended as a routine updating of the Department's strategic goals and existing procedures.... The ACA's Charter is required to be renewed every two years from the date of the Secretary of Labor's... Secretary's priorities. FOR FURTHER INFORMATION CONTACT: Mr. John V. Ladd, Administrator, Office of...

  13. 78 FR 2445 - Notice of Intent To Renew the Advisory Committee on Apprenticeship (ACA) Charter

    Science.gov (United States)

    2013-01-11

    ... Employment and Training Administration Notice of Intent To Renew the Advisory Committee on Apprenticeship... Renew Charter. SUMMARY: The Secretary of Labor has determined that the renewal of a national advisory... renew the ACA Charter with revisions. The revisions are not intended to change the purpose or...

  14. Tratamiento de la insuficiencia cardíaca: nuevas estrategias terapéuticas

    National Research Council Canada - National Science Library

    Herreros, Jesús; Trainini, Jorge Carlos; Bernal, José Manuel; Gutiérrez, Francisco; Cabo, Javier; Chachques, Juan Carlos

    2011-01-01

    .... Sin embargo, la desproporción entre el número de pacientes con una insuficiencia cardíaca terminal y los donantes potenciales restringe el trasplante a aquellos pacientes sin otras posibilidades de tratamiento y ha generado alternativas...

  15. Consideraciones nutricionales en el paciente con falla cardíaca crónica

    Directory of Open Access Journals (Sweden)

    Mario A. Hernández, MD

    2012-11-01

    Full Text Available La insuficiencia cardíaca congestiva es un síndrome caracterizado por reducción del gasto cardíaco, aumento de las presiones de llenado ventricular y activación neuroendocrina, que lleva a un proceso de fibrosis y apoptosis de la célula cardíaca. Afecta alrededor de 23 millones de personas en el mundo y confiere un pésimo pronóstico una vez se diagnostica. Desde el punto de vista fisiopatológico, la relación entre citocinas pro-inflamatorias, activación neuro-hormonal y alteraciones gastrointestinales conduce a un estado denominado caquexia cardíaca, determinado por pérdida acelerada de peso, fatiga, reducción de la fuerza muscular, anorexia y disminución de la calidad de vida; este proceso es capaz de deteriorar aún más el pronóstico vital de estos pacientes. En las últimas dos décadas, se han realizado avances en el tratamiento farmacológico y eléctrico de la falla cardíaca; sin embargo los estudios en el campo no farmacológico son pocos, en especial en el aspecto nutricional, y así mismo son escasas las recomendaciones de las guías internacionales acerca del tema. En estudios pequeños, una aproximación nutricional ha demostrado impactar de manera positiva la calidad de vida y tolerancia al ejercicio, si bien se requieren grandes estudios para determinar la viabilidad de este abordaje en pacientes con falla cardíaca.

  16. Estrategias en la prevención de la insuficiencia cardíaca

    Directory of Open Access Journals (Sweden)

    Vukasovig R. José Luis, MD, FACC

    2012-11-01

    Full Text Available Aproximadamente 1 a 2% de la población adulta tiene insuficiencia cardíaca, llegando a valores sobre el 10% en mayores de 70 años de edad. Una adecuada estrategia en la prevención de la Insuficiencia Cardíaca implica tener un manejo precoz en aquellas etiologías que la producen tales como: hipertensión arterial, enfermedad coronaria, valvulopatías y miocardiopatías. La hipertensión arterial es la primera causa de insuficiencia cardíaca en Chile y se expresa principalmente a través de hipertrofia ventricular izquierda y disfunción diastólica. La enfermedad coronaria genera insuficiencia cardíaca por medio de infarto al miocardio y la isquemia miocárdica sostenida (tejido hibernado, para evitar el compromiso ventricular deben controlarse rigurosamente los factores de riesgo de enfermedad coronaria. En caso de presentarse una obstrucción coronaria aguda se debe reestablecer el flujo coronario a la brevedad para disminuir la necrosis de miocitos. Actualmente las valvulopatías están siendo intervenidas cada vez más precozmente con el fin de evitar la remodelación ventricular patológica irreversible. En relación a las miocardiopatías se debe enfatizar en la necesidad de una detección precoz de la toxicidad por drogas antineoplásicas (ej antraciclinas, del mismo modo debemos preocuparnos de factores emergentes que conducen a insuficiencia cardíaca, ejemplo obesidad.

  17. El juego como herramienta de aprendizaje en niños con enfermedad celíaca

    OpenAIRE

    Guzman, L.; Borobia, P.; Cueto Rua, E.; Pérez, M.(Institute for Fundamental Theory, Department of Physics, University of Florida, Gainesville, FL, 32611, U.S.A.)

    2010-01-01

    Se presenta un proyecto de trabajo de terreno de alumnos del último año de la carrera de Ciencias Médicas que se encuentren cursando Pediatría, quienes llevarán a cabo un trabajo de taller, y en donde se trabajará con los niños celiacos que concurren a las reuniones de la Asociación Celíaca Argentina (ACA).

  18. Taquiarritmias postoperatorias en la cirugía cardíaca del adulto. Profilaxis

    Directory of Open Access Journals (Sweden)

    Fernando Enríquez

    2010-10-01

    Full Text Available Las arritmias en el periodo postoperatorio de la cirugía cardíaca suelen ser un hallazgo común ligado a múltiples mecanismos. Las condiciones particulares inherentes al acto quirúrgico pueden iniciar, facilitar o agravar un evento arrítmico por modificaciones en el sustrato anatómico y en sus moduladores. Aunque tradicionalmente consideradas como arritmias transitorias, diversos estudios muestran su asociación con una mayor morbimortalidad, riesgo de ictus, compromiso hemodinámico, iatrogenia, estancia hospitalaria y mayor gasto sanitario. La presente revisión aborda la información de que disponemos de las taquiarritmias en el postoperatorio de la cirugía cardíaca, y las pautas de actuación basadas en la evidencia.

  19. QUALIDADE DE VIDA DE IDOSOS COM INSUFICIÊNCIA CARDÍACA

    OpenAIRE

    Santos, Analyane Silva; Espírito Santo, Fatima Helena; Universidade Federal Fluminense

    2010-01-01

    INTRODUÇÃO:A Insuficiência Cardíaca (IC) é uma patologia crônica que acomete milhões de pessoas no mundo inteiro, principalmente o idoso, sendo esta o último estágio de muitas patologias que acometem o coração Braunwald (1992, p.1375) a define  como: [...] um estado fisiopatológico em que alguma anormalidade de função cardíaca é responsável pela incapacidade do coração em bombear sangue numa freqüência proporcional às necessidades metabólicas dos tecidos e/ou só pode fazê-lo numa pressão de e...

  20. Importancia de los aspectos psicosociales en la enfermedad celíaca

    Directory of Open Access Journals (Sweden)

    Trini Fragoso Arbelo

    2002-06-01

    Full Text Available Se revisan los conceptos clínicos actuales sobre la enfermedad celíaca. Se definen con precisión los términos enfermedad celíaca activa, silente, latente y potencial. Se enfatiza en los aspectos psicosociales que influyen en su tratamiento y se trazan pautas generales acerca del manejo integral de los pacientes afectados, dada la importancia de la dieta sin gluten de por vida como único tratamiento.The current clinical concepts of celiac disease are reviewed. The terms active, silent, latent and potential related to celiac disease are accurately defined. Emphasis is made on the psychosocial aspects influencing its treatment and general guidelines are drawn on the comprehensive management of the patients suffering from this disease, given the importance of diet without gluten as the only lifelong treatment.

  1. Remodelación cardíaca e inflamación

    OpenAIRE

    Martínez Rosas,Martín

    2006-01-01

    La remodelación cardíaca es una respuesta progresiva del corazón al daño agudo y crónico sin importar su etiología. Este proceso es caracterizado por cambios en el tamaño, en la forma y en la función del corazón y está asociado a un mal pronóstico en pacientes con insuficiencia cardíaca. El infarto agudo del miocardio es la causa más común del proceso de remodelado. En los primeros minutos posteriores al daño en la zona isquémica existe un importante aumento en la síntesis y liberación de cit...

  2. QUALIDADE DE VIDA DE IDOSOS COM INSUFICIÊNCIA CARDÍACA

    OpenAIRE

    Santos, Analyane Silva; Espírito Santo, Fatima Helena; Universidade Federal Fluminense

    2010-01-01

    INTRODUÇÃO:A Insuficiência Cardíaca (IC) é uma patologia crônica que acomete milhões de pessoas no mundo inteiro, principalmente o idoso, sendo esta o último estágio de muitas patologias que acometem o coração Braunwald (1992, p.1375) a define  como: [...] um estado fisiopatológico em que alguma anormalidade de função cardíaca é responsável pela incapacidade do coração em bombear sangue numa freqüência proporcional às necessidades metabólicas dos tecidos e/ou só pode fazê-lo numa pressão de e...

  3. Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro

    Directory of Open Access Journals (Sweden)

    Pytelková Jana

    2012-01-01

    Full Text Available Abstract Background Enzymatic allergens of storage mites that contaminate stored food products are poorly characterized. We describe biochemical and immunological properties of the native alpha-amylase allergen Aca s 4 from Acarus siro, a medically important storage mite. Results A. siro produced a high level of alpha-amylase activity attributed to Aca s 4. This enzyme was purified and identified by protein sequencing and LC-MS/MS analysis. Aca s 4 showed a distinct inhibition pattern and an unusual alpha-amylolytic activity with low sensitivity to activation by chloride ions. Homology modeling of Aca s 4 revealed a structural change in the chloride-binding site that may account for this activation pattern. Aca s 4 was recognized by IgE from house dust mite-sensitive patients, and potential epitopes for cross-reactivity with house dust mite group 4 allergens were found. Conclusions We present the first protein-level characterization of a group 4 allergen from storage mites. Due to its high production and IgE reactivity, Aca s 4 is potentially relevant to allergic hypersensitivity.

  4. Qualidade de vida em doentes com insuficiência cardíaca congestiva

    OpenAIRE

    Nave Leal, Elisabete; Pais-Ribeiro,José Luís

    2008-01-01

    Síndroma clínico de carácter progressivo com uma alta prevalência e incidência com um prognóstico adverso. Supõe o aparecimento de sintomas clínicos como dispneia, fadiga e/ou edema periférico associado a uma demonstração objectiva de disfunção cardíaca.

  5. Triagem sorológica para doença celíaca em adolescentes

    Directory of Open Access Journals (Sweden)

    Maria Ester Pereira da Conceição-Machado

    2015-03-01

    Full Text Available OBJETIVO: Este estudo objetivou identificar a soroprevalência da doença celíaca em adolescentes de escolas públicas da cidade de Salvador, Bahia. MÉTODO: Trata-se de um estudo transversal com amostra probabilística de 1.213 adolescentes de 11 a 17 anos, de ambos os sexos. O índice de massa corporal foi utilizado para o diagnóstico do estado nutricional, adotando-se os percentis segundo idade e sexo, propostos pela World Health Organization. O anticorpo anti-transglutaminase humana da classe imunoglobulina A (anti-tTG-IgA foi adotado como teste sorológico para triagem da doença celíaca e foi determinado pela técnica do ensaio imunoabsorvente ligado à enzima (ELISA. Foi realizada análise descritiva, utilizando-se a proporção e a média (desvio padrão. RESULTADOS: O sexo feminino predominou entre os adolescentes, e a maioria encontrava-se com adequado estado nutricional. O anticorpo anti-tTG-IgA foi positivo em 6/1.213 (0,49% adolescentes. CONCLUSÃO: A soroprevalência de doença celíaca entre os adolescentes estudados foi 0,49%. Novas investigações são necessárias para confirmar a prevalência de doença celíaca nessa faixa etária.

  6. Insuficiencia cardíaca: Aspectos básicos de una epidemia en aumento

    Directory of Open Access Journals (Sweden)

    Javier E. Pereira-Rodríguez

    2016-03-01

    Full Text Available La insuficiencia cardíaca representa un gran problema de salud pública en el mundo, ya sea por su creciente prevalencia, como por el costo que implica el tratamiento adecuado de los pacientes que la padecen. Esta afectación es un complejo problema que se origina de un desorden estructural o funcional y deteriora la capacidad de llenado o expulsión ventricular de la sangre. Se caracteriza a su vez, por la presencia de síntomas cardinales, como la disnea, fatiga y retención de líquido. Las principales causas de la insuficiencia cardíaca son la enfermedad isquémica, la cardiopatía hipertensiva, las cardiomiopatías dilatadas y las valvulopatias. En las etapas iniciales, la función cardíaca puede ser normal en reposo, pero no aumenta adecuadamente con el ejercicio; en estadios avanzados se vuelve anormal también en reposo. En esta revisión se resumen los aspectos básicos principales de este síndrome.

  7. Nutritional supplements

    DEFF Research Database (Denmark)

    Petersen, Gry Bjerg; Andersen, Jens Rikardt

    2015-01-01

    , metal, gritty, consistence and ability to drink 150 ml (one glass), and the patients arranged the drinks in order of preference. Results: The sensory qualities differed significantly concerning sweet (p...Background: Several studies have indicated that cancer patients have significantly altered taste sensitivity without specifying the preferences. One of the related problems is low compliance to nutritional therapy with oral nutritional supplements (ONS) in patients suffering severe weight loss....... Objective: We wanted to investigate taste preferences and sensoric characteristics among three usually used ONS in patients with malignant haematological disease during cytotoxic treatment. Design: Tested drinks were: Protin® (protein-enriched-milk, ARLA), Nutridrink® (NUTRICIA) and hospital-produced drink...

  8. Complicações cardíacas em cirurgia vascular

    Directory of Open Access Journals (Sweden)

    Karla Scamardi Martins Pereira

    2016-01-01

    Full Text Available Resumo Contexto Aproximadamente 60% dos pacientes portadores de doença arterial oclusiva crônica periférica têm doença coronariana grave, sendo que a principal causa de morte no pós-operatório de cirurgia vascular de grande porte é o infarto agudo do miocárdio. Objetivos Determinar a prevalência da doença coronariana em pacientes submetidos a cirurgia vascular eletiva de grande porte e sua relação com as complicações cardiológicas pós-operatórias. Métodos Foram analisados 200 pacientes submetidos a cirurgia vascular arterial eletiva: doença obstrutiva carotídea, aortoilíaca e femoropoplítea distal e doença aneurismática de aorta abdominal e de artérias ilíacas. Os pacientes constituíram três grupos: grupo I, sem doença coronariana; grupo II, com doença coronariana assintomática; e grupo III, com doença coronariana sintomática. As complicações cardiológicas consideradas foram infarto agudo do miocárdio fatal e não fatal, insuficiência cardíaca congestiva, choque cardiogênico, fibrilação atrial aguda e outras arritmias. Resultados Complicações cardíacas ocorreram em 11 pacientes (5,5%: três infartos agudos do miocárdio não fatais (1,5% sempre em pacientes do grupo III. A complicação cardíaca mais frequente foi arritmia (exceto fibrilação atrial ocorrida em cinco (2,5% pacientes, sendo três do grupo II. A mortalidade precoce foi de nove pacientes (4,5%. Apenas uma morte foi decorrente de problema cardíaco: choque cardiogênico em paciente do grupo III. Conclusões A doença coronariana não foi preditora de óbito nos pacientes submetidos a cirurgia vascular periférica de grande porte. A sobrevida dos pacientes com ou sem doença coronariana não mostrou diferenças estatísticas.

  9. Annual Statistical Supplement, 2008

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2008 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  10. Annual Statistical Supplement, 2004

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2004 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  11. Annual Statistical Supplement, 2006

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2006 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  12. Annual Statistical Supplement, 2016

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2016 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  13. Annual Statistical Supplement, 2010

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2010 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  14. Annual Statistical Supplement, 2002

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2002 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  15. Annual Statistical Supplement, 2003

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2003 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  16. Annual Statistical Supplement, 2011

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2011 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  17. Annual Statistical Supplement, 2000

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2000 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  18. Annual Statistical Supplement, 2015

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2015 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  19. Annual Statistical Supplement, 2009

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2009 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  20. Annual Statistical Supplement, 2014

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2014 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  1. Annual Statistical Supplement, 2007

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2007 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  2. Annual Statistical Supplement, 2005

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2005 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  3. Annual Statistical Supplement, 2001

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2001 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  4. Key Provisions of the Patient Protection and Affordable Care Act (ACA): A Systematic Review and Presentation of Early Research Findings.

    Science.gov (United States)

    French, Michael T; Homer, Jenny; Gumus, Gulcin; Hickling, Lucas

    2016-10-01

    To conduct a systematic literature review of selected major provisions of the Affordable Care Act (ACA) pertaining to expanded health insurance coverage. We present and synthesize research findings from the last 5 years regarding both the immediate and long-term effects of the ACA. We conclude with a summary and offer a research agenda for future studies. We identified relevant articles from peer-reviewed scholarly journals by performing a comprehensive search of major electronic databases. We also identified reports in the "gray literature" disseminated by government agencies and other organizations. Overall, research shows that the ACA has substantially decreased the number of uninsured individuals through the dependent coverage provision, Medicaid expansion, health insurance exchanges, availability of subsidies, and other policy changes. Affordability of health insurance continues to be a concern for many people and disparities persist by geography, race/ethnicity, and income. Early evidence also indicates improvements in access to and affordability of health care. All of these changes are certain to ultimately impact state and federal budgets. The ACA will either directly or indirectly affect almost all Americans. As new and comprehensive data become available, more rigorous evaluations will provide further insights as to whether the ACA has been successful in achieving its goals. © Health Research and Educational Trust.

  5. Effects of Transgenic Tobacco Plants Expressing ACA Gene from Amaranthus caudatus on the Population Development of Myzus persicae

    Institute of Scientific and Technical Information of China (English)

    GUOHong-Nian; JIAYan-Tao; ZHOUYong-Gang; ZHANGZhen-Shan; OUYANGQing; JIANGYing; TIANYing-Chuan

    2004-01-01

    To investigate the possible function of the agglutinin from Amaranthus caudatus L. (ACA) in plant defending against insect pests, ACA cDNA was cloned by RT-PCR and the 5' and 3' sequences were confirmed by rapid amplification of cDNA ends (RACE). The phloem-specific expression vector of ACA gene, pBCACAc, was constructed based on the plant binary vector pBC438 and transfered into tobacco plants via Agrobacterium-mediated transformation method. Results from PCR and Southern blotting analysis showed that AOA gene was integrated into the genomes of transformed plants and the transgene integration varied from one to four estimated copies per genome. Western blotting analysis indicated that ACA gene was transcribed and translated in the transgenic plants. The bioassay of Myzus persicae Sulzer on detached leaves demonstrated that the 78% transgenic tobacco plants displayed an average aphid-resistant rate of more than 75%. Some apterous progeny of M. persicae were found dead on the resistant plants. These results indicate that ACA gene should be an effective aphid-resistant gene and could be valuable for application in crop breeding for aphid resistance.

  6. Registro Nacional de Internación por Insuficiencia Cardíaca

    Directory of Open Access Journals (Sweden)

    Raúl Borracci

    2009-01-01

    Full Text Available IntroducciónLa insuficiencia cardíaca representa una de las principales causas de internación con una tasa elevada de complicaciones y cuyo enfoque no parece que haya mejorado en los últimos años.ObjetivosConocer el perfil epidemiológico y clínico, analizar las medidas terapéuticas y la evolución durante la internación y a los 3 meses de pacientes admitidos por insuficiencia cardíaca descompensada.Material y métodosRegistro prospectivo, multicéntrico de pacientes internados por insuficiencia cardíaca descompensada en 31 centros de todo el país que aceptaron la invitación a participar del registro. Se analizaron variables vinculadas con la presentación y la evolución hospitalaria y a los 90 días.ResultadosSe incluyeron 736 pacientes, mediana de edad 74 años (64-82, 41% mujeres, 75% hipertensos, 27% diabéticos, 20% infarto previo, 30% fibrilación auricular crónica, 17% insuficiencia renal crónica, 18% EPOC. Sólo el 29% era de etiología isquémico-necrótica. El 47% había tenido internación en el último año por insuficiencia cardíaca. Las causas de descompensación más frecuentes fueron infecciones, suspensión del tratamiento y transgresión alimentaria.Las formas graves de presentación (shock cardiogénico, edema agudo de pulmón, anasarca representaron el 30%. El 60% de los pacientes se internaron en área crítica. La mediana de permanencia fue de 7 (5-11 días. La mortalidad hospitalaria fue del 8%. A los 90 días, la reinternación fue del 24,5% y la mortalidad posalta fue del 12,8%.ConclusionesEl presente registro confirma que se trata de una población de edad avanzada con una incidencia alta de comorbilidades. Muchas descompensaciones ocurren por factores prevenibles. La tasa de complicaciones es elevada y no se redujo en la última década.REV ARGENT CARDIOL 2009;77:33-39.

  7. Estetoscópio digital como ferramenta inovadora no ensino da ausculta cardíaca

    Directory of Open Access Journals (Sweden)

    Claudio Tinoco Mesquita

    2013-02-01

    Full Text Available O exame físico cardiovascular, em particular a ausculta cardíaca, é uma das habilidades clínicas mais difíceis para os alunos durante seu treinamento médico. Estudos sugerem que o uso de tecnologias, como o estetoscópio digital, aumente a acurácia do exame clínico, entretanto, seu impacto no ensino da propedêutica da ausculta cardíaca em alunos de graduação de Medicina não é conhecido. O objetivo é demonstrar a utilidade do estetoscópio digital, em comparação com métodos tradicionais, como instrumento de ensino da ausculta cardíaca. Estudo de intervenção, longitudinal, controlado, unicêntrico e randomizado. Foram inscritos 38 alunos de medicina para um curso de semiologia cardiovascular com duração de oito semanas. Definiu-se um programa com aulas expositivas e à beira do leito nas enfermarias de Cardiologia. Nas aulas práticas, os alunos foram randomizados em dois grupos: 1 (n = 21 estetoscópio digital (Littmann® modelo 3200, 3M; e 2 (n = 17 estetoscópios convencionais. Foi realizada uma avaliação pré-treinamento, através de um teste utilizando o software Heart Sounds®, que foi repetida ao final do curso. As médias das avaliações foram comparadas pelo teste T pareado e não pareado. Observa-se que, ao final do curso, houve uma melhora significativamente maior no grupo que utilizou o estetoscópio digital (51,9% quando comparado ao grupo que utilizou o estetoscópio convencional (29,5%. Intervenções de curta duração para o ensino de semiologia cardíaca são capazes de contribuir de modo significativo para melhora da proficiência da identificação dos sons cardíacos. O uso do estetoscópio digital demonstrou ser um fator positivo no ensino dessas habilidades.

  8. SENTIDOS DO SER-AÍ-MULHER-APÓS-CIRURGIA-CARDÍACA À LUZ DE HEIDEGGER

    OpenAIRE

    Thaís Vasconselos Amorim; Anna Maria de Oliveira Salimena; Maria Carmen Simões Cardoso de Melo; Ívis Emília de Oliveira Souza; Lúcia de Fátima da Silva

    2013-01-01

    Estudio cualitativo con objetivo de presentar el descubrimiento de sentidos del ser-mujer-después-cirugía-cardíaca sostenidos por Heidegger. El escenario fue un hospital de alta complejidad cardiovascular en Minas Gerais, Brasil. La fase de campo se produjo en diciembre de 2011 y enero de 2012, y las entrevistadas fueron llevadas a cabo a partir de la pregunta: ¿Cómo es su día a día después de la cirugía? Las lecturas y escuchas de testimonios posibilitaron análisis y interpretación. La mujer...

  9. Taquiarritmias postoperatorias en la cirugía cardíaca pediátrica

    Directory of Open Access Journals (Sweden)

    Fernando Enríquez

    2010-10-01

    Full Text Available Las arritmias postoperatorias son frecuentes en la cirugía de las cardiopatías congénitas. Esta revisión actualiza y expone la evidencia científica sobre la incidencia, fisiopatología, profilaxis y tratamiento de las taquiarritmias en la cirugía cardíaca pediátrica. Existe muy poca información basada en estudios aleatorizados en pediatría, siendo la mayoría de las publicaciones series de diversos centros quirúrgicos.

  10. Hidatidosis cardíaca con embolismo aórtico

    Directory of Open Access Journals (Sweden)

    M.G. Castignola

    2013-01-01

    Full Text Available La hidatidosis cardíaca con embolismo aórtico es una entidad extremadamente infrecuente. Se produce por una rotura o un desprendimiento total o parcial de un quiste hidatídico cardíaco. Presentamos el caso de un niño de 11 años de edad con manifestaciones de isquemia de miembros inferiores de inicio súbito y antecedentes de disnea y dolor torácico. Se describe la utilidad de la angiotomografía computada multidetector en la evaluación de este tipo de afecciones.

  11. Conceptos actuales en enfermedad celíaca Current concepts on celiac disease

    OpenAIRE

    2013-01-01

    En enero de 2012, la ESPGHAN (European Society of Paediatric Gastroenterology, Hepatology and Nutrition) publica los nuevos criterios para el diagnóstico de la enfermedad celíaca (EC), aplicando criterios basados en la evidencia y nos da una nueva y completa definición de dicha enfermedad: “Es un trastorno sistémico inmune provocado por el gluten y sus prolaminas en individuos genéticamente susceptibles y se caracteriza por la presencia de una combinación variable de manifestaciones clínicas,...

  12. Impacto da Terapia de Ressincronização Cardíaca na Qualidade de Vida em Doentes com Insuficiência Cardíaca Congestiva Refractária

    OpenAIRE

    Nave Leal, E; Pais Ribeiro, JL; Oliveira, MM; Nogueira da Silva, M.; J. Feliciano; Cunha, P.; Soares, RM; Santos, S.(Laboratorio de Instrumentacao e Fisica Experimental de Particulas - LIP, Lisboa, Portugal); Alves, S.; Rebelo da Silva, N; Cruz Ferreira, R

    2008-01-01

    A terapêutica de ressincronização cardíaca (TRC), associada ou não a cardioversor-desfibrilhador, está recomendada no tratamento de doentes com insuficiência cardíaca congestiva (ICC) refractária e disfunção sistólica grave do ventrículo esquerdo, com evidência de dessíncronia. Objectivo: avaliar o impacto da TRC na qualidade de vida de doentes com ICC refractária ao tratamento farmacológico optimizado.

  13. Hiperpotassemia na vigência de espironolactona em pacientes com insuficiência cardíaca descompensada

    OpenAIRE

    2008-01-01

    FUNDAMENTO: A incidência de hiperpotassemia relacionada à espironolactona é baixa na insuficiência cardíaca estável, entretanto não foi estudada durante a descompensação. OBJETIVO: Avaliar a influência da espironolactona na insuficiência cardíaca descompensada sobre o potássio sérico. MÉTODOS: Em um estudo de coorte, selecionamos pacientes hospitalizados por descompensação da insuficiência cardíaca, FEVE < 0,45 e potássio sérico entre 3,5 e 5,5 mEq/l. Os pacientes foram divididos segundo o us...

  14. Doença celíaca é super-representada em pacientes com constipação

    Directory of Open Access Journals (Sweden)

    Rolf A. A. Pelleboer

    2012-04-01

    Full Text Available OBJETIVO: Tem sido sugerido que pacientes com constipação sejam triados para doença celíaca. Da mesma forma, recomenda-se a investigação desses pacientes para hipotiroidismo e hipercalcemia. Contudo, nenhuma evidência para essas recomendações está disponível até o momento. Assim, propusemos-nos determinar a prevalência de doença celíaca, hipotiroidismo e hipercalcemia em crianças com constipação. MÉTODOS: Estudo de coorte prospectivo com 370 pacientes consecutivos que preencheram os critérios de Roma III para constipação. Esses pacientes foram encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. RESULTADOS: A biópsia comprovou doença celíaca em sete desses pacientes. Isso é significativamente mais alto (p < 0,001 do que a prevalência de 1:198 de doença celíaca nos Países Baixos. Dois pacientes tinham tiroidite autoimune. Nenhum paciente tinha hipercalcemia. CONCLUSÕES: Conclui-se que a doença celíaca é significativamente super-representada em pacientes com constipação encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. Todos esses pacientes devem, portanto, ser triados para doença celíaca.

  15. Structure and Functional Studies of the CS Domain of the Essential H/ACA Ribonucleoparticle Assembly Protein SHQ1

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Mahavir; Gonzales, Fernando A.; Cascio, Duilio; Heckmann, Nathanael; Chanfreau, Guillaume; Feigon, Juli; (UCLA)

    2009-03-16

    H/ACA ribonucleoprotein particles are essential for ribosomal RNA and telomerase RNA processing and metabolism. Shq1p has been identified as an essential eukaryotic H/ACA small nucleolar (sno) ribonucleoparticle (snoRNP) biogenesis and assembly factor. Shq1p is postulated to be involved in the early biogenesis steps of H/ACA snoRNP complexes, and Shq1p depletion leads to a specific decrease in H/ACA small nucleolar RNA levels and to defects in ribosomal RNA processing. Shq1p contains two predicted domains as follows: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain, and a C-terminal region of high sequence homology called the Shq1 domain. Here we report the crystal structure and functional studies of the Saccharomyces cerevisiae Shq1p CS domain. The structure consists of a compact anti-parallel {beta}-sandwich fold that is composed of two {beta}-sheets containing four and three {beta}-strands, respectively, and a short {alpha}-helix. Deletion studies showed that the CS domain is required for the essential functions of Shq1p. Point mutations in residues Phe-6, Gln-10, and Lys-80 destabilize Shq1p in vivo and induce a temperature-sensitive phenotype with depletion of H/ACA small nucleolar RNAs and defects in rRNA processing. Although CS domains are frequently found in co-chaperones of the Hsp90 molecular chaperone, no interaction was detected between the Shq1p CS domain and yeast Hsp90 in vitro. These results show that the CS domain is essential for Shq1p function in H/ACA snoRNP biogenesis in vivo, possibly in an Hsp90-independent manner.

  16. Fish oil supplements, longevity and aging

    NARCIS (Netherlands)

    Magalhães, de João Pedro; Müller, Michael; Rainger, G.E.; Steegenga, Wilma

    2016-01-01

    Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains show

  17. Hemotransfusión como factor de riesgo en cirugía cardíaca

    OpenAIRE

    Serrano Valdés,Xenia

    2006-01-01

    El sangrado ocurre frecuentemente en pacientes que se someten a cirugía cardíaca. Aunque el sangrado inesperado después de la cirugía es común, reducir este sangrado es un objetivo importante, debido a que éste se asocia a importantes complicaciones. El sangrado durante y después de las operaciones cardíacas y los efectos de la hemodilución durante la circulación extracorpórea, frecuentemente conllevan a la transfusión de sangre. A pesar de los esfuerzos institucionales para disminuir la frec...

  18. COMPLICACIONES DE LA CIRUGÍA CARDÍACA VIDEO-ASISTIDA / Complications of video-assisted heart surgery

    OpenAIRE

    Fausto L. Rodríguez Salgueiro; Raúl García Rojas; Elizabeth Rodríguez Rosales; Dania Valera Pérez; Antonio de Arazoza Hernández

    2012-01-01

    ResumenLa cirugía cardiovascular video-asistida incluye procedimientos extremadamente complejos, como la revascularización miocárdica y las sustituciones valvulares, no exentos de complicaciones fácilmente prevenibles y tratables. En este artículo se discuten las complicaciones de la cirugía cardíaca video-asistida, propias de la posición del paciente: respiratorias, cardiovasculares, quirúrgicas, infecciosas, entre otras. La cirugía cardíaca video-asistida brinda al paciente innumerables ven...

  19. INSUFICIENCIA CARDÍACA CONGESTIVA O COR PULMONALE Congestive heart failure or Cor Pulmonale

    Directory of Open Access Journals (Sweden)

    Oscar Ernesto Amarís Peña

    2006-06-01

    Full Text Available La insuficiencia cardíaca es una de las principales causas de muerte cardiovascular y se presenta como consecuencia, en más del 70 por ciento de los casos, de las dos enfermedades cardiovasculares de mayor prevalencia: la hipertensión arterial y la enfermedad coronaria. La disnea y el edema en los miembros inferiores son los dos criterios más usados para el diagnóstico de insuficiencia cardíaca congestiva y estos son, justamente, las principales manifestaciones de los pacientes con Cor Pulmonale. Este documento propone algunos criterios para el diagnóstico diferencial de las dos entidades.Heart failure is one of the most important causes of cardiovascular death, as consequence of arterial hypertension or coronary heart disease. Dyspnea and legs edema are the commonest symptoms of congestive heart failure, but there are important symptoms in Cor Pulmonale, too. This paper propose some distinctive clues to differential diagnosis.

  20. Identification and characterization of two novel box H/ACA snoRNAs from Schizosaccharomyces pombe

    Institute of Scientific and Technical Information of China (English)

    LI Siguang; ZHOU Hui; ZHANG Peng; LUO Yuping; QU Lianghu

    2005-01-01

    Through constructing a specialized cDNA library based on small RNAs isolated from partial purified nuclei of Schizosaccharomyces pombe, two novel noncoding RNAs, termed Sp15-70 and Sp18-61, have been identified. Bioinformatics analysis reveals that both the novel RNAs possess a typical secondary structure of box H/ACA snoRNA and antisense elements to rRNAs. According to the relationship between the structure and function of box H/ACA snoRNA, Sp15-70 was predicted to direct pseudouridylation in 25S rRNA at U2401 and U2298; Sp18-61 was predicted to direct pseudouridylation in 18S rRNA at U208 and 25S rRNA at U2341. The four predicted pseudouridylation sites were all verified experimentally by the CMC-primer extension analysis. Both Sp15-70 and Sp18-61 were encoded by single copies which were located in the intergenic regions between the CDS of two protein-coding genes on chromosome Ⅰ and Ⅲ of S. pombe, respectively. Putative TATA-like elements can be found upstream from the 5′ end of these snoRNA genes, suggesting that they could be transcribed from their own promoters. Comparison of the two snoRNAs and their functional homologues in diverse organisms reveals that extensive recombinations among different snoRNAs have occurred during the evolution from their primitive progenitors.

  1. Tratamento endovascular da oclusão das artérias ilíacas

    Directory of Open Access Journals (Sweden)

    Pedron Cleoni

    2001-01-01

    Full Text Available A oclusão das artérias ilíacas é uma patologia freqüente. Várias opções cirúrgicas existem para o seu tratamento, como a ponte aorto-bifemoral, a ponte femoro-femoral cruzada, o implante de endoprótese e outros. A ponte aorto-bifemoral é considerada o tratamento com melhores resultados. O tratamento endovascular da oclusão das artérias apresenta alta taxa de sucesso e baixo índice de complicações. Realizamos este tratamento em 24 pacientes, com idade média de 61 anos, variando de 39 a 82 anos. A indicação foi claudicação intermitente em 19 pacientes e isquemia crítica em cinco. O fator de risco mais freqüente foi tabagismo em 19 pacientes. A taxa de sucesso técnico na ultrapassagem da lesão foi de 91,7% e a taxa de patência foi de 71% em um ano. Os bons resultados com o tratamento endovascular nas oclusões das artérias ilíacas, com baixas taxas de morbidade e mortalidade, sugerem a inclusão deste procedimento no arsenal terapêutico.

  2. La terapia celular como tratamiento de la insuficiencia cardíaca crónica

    Directory of Open Access Journals (Sweden)

    Ricardo Sanz

    2008-01-01

    Full Text Available Hasta hace poco tiempo se pensaba que el miocardio era un tejido sin capacidad de regeneración. El descubrimiento de progenitores celulares en el corazón de mamíferos adultos y la evidencia científica de que la reparación cardíaca existe han cambiado esta creencia, abriendo una nueva vía de investigación en el tratamiento de las enfermedades cardiovasculares. Durante años, circunscrita al ámbito de la investigación básica y de los ensayos preclínicos, esta nueva línea de investigación se ha trasladado al ámbito clínico, donde se están desarrollando ensayos en humanos para evaluar la seguridad, factibilidad y eficacia de dicha terapia celular en la regeneración miocárdica. En esta revisión nos centraremos en la terapia celular de la insuficiencia cardíaca crónica en humanos, recogiendo los antecedentes, tipos de células y vías de administración, así como los principales ensayos clínicos publicados hasta el momento.

  3. Tratamento otimizado e redução da frequência cardíaca na insuficiência cardíaca crônica

    Directory of Open Access Journals (Sweden)

    Irineu Blanco Moreno

    2013-11-01

    Full Text Available FUNDAMENTO: A Insuficiência Cardíaca (IC é uma síndrome que cursa com má evolução nas formas avançadas. O bloqueio neuro-hormonal modifica essa história natural; no entanto, ele com frequência é subotimizado. OBJETIVO: Neste estudo procuramos verificar em qual percentual médicos cardiologistas habituados no tratamento da IC conseguem prescrever as doses-alvo dos medicamentos de comprovada eficácia. MÉTODOS: Foram selecionados consecutivamente 104 pacientes ambulatoriais com disfunção sistólica, todos sob tratamento estabilizado. Avaliaram-se dados demográficos e o tratamento verificando-se as doses atingidas. Os achados são apresentados em percentual e fizeram-se correlações entre as diferentes variáveis. RESULTADOS: A idade média dos pac. foi de 64,1 ± 14,2 anos, com PAS 115,4 ± 15,3 mmHg, FC de 67,8 ± 9,4 bpm, peso 76,0 ± 17,0 kg e em ritmo sinusal (90,4%. Quanto ao tratamento, 93,3% estavam recebendo um bloqueador do SRA (52,9% IECA, todos recebiam betabloqueador (BB, sendo o carvedilol o mais prescrito (92,3%. Quanto às doses: 97,1% dos que recebiam um BRA estavam com dose abaixo da ideal; os que recebiam IECA 52,7% receberam dose otimizada. Quanto ao BB, em 76,0% foi possível prescrever as doses alvos. Nesse grupo de pac. a maioria com dose alvo do BB, pode-se observar que 36,5% apresentavam frequência cardíaca igual ou maior que 70 bpm em ritmo sinusal. CONCLUSÕES: Médicos cardiologistas habituados no tratamento da IC conseguem prescrever as doses-alvo de inibidores da ECA e BB para a maioria dos pac. Mesmo recebendo as doses preconizadas, cerca de um terço dos pac. persiste com FC acima de 70 bpm e deveria ter seu tratamento otimizado.

  4. Prevention under the Affordable Care Act (ACA: Has the ACA Overpromised and under Delivered?; Comment on “Interrelation of Preventive Care Benefits and Shared Costs under the Affordable Care Act (ACA”

    Directory of Open Access Journals (Sweden)

    Carol Molinari

    2014-08-01

    Full Text Available This policy brief discusses preventive care benefits and cost-sharing included in health insurance provisions of the Affordable Care Act (ACA legislation and highlights some consequences to Americans and the country in terms of healthcare costs and value.

  5. 基于表达序列标签的萝卜ACA36基因簇鉴定%Identification of ACA36 gene cluster in Raphanus sativus from expressed sequence tags

    Institute of Scientific and Technical Information of China (English)

    徐玲; 程加富; 胡娜; 殷秋平

    2009-01-01

    利用国际公用的表达序列标签(EST)数据库资源,运用生物信息学分析方法,在萝卜(Raphanus sativus)一条表达序列标签中发现一个新的snoRNA基因簇.此基因簇含有一个box H/ACA snoRNA基因和两个box C/D snoRNA基因,分别命名为RsACA36、RssnoR66和RsSNORD88.ACA36可形成典型的box H/ACA snoRNA双茎环二级结构;snoR66和SNORD88都具有典型的C盒与D盒保守元件,末端存在反向互补序列;三个snoRNA都含有能和核糖体RNA互补配对的反向互补序列.

  6. Effects of Supplemental Dietary Phytase and 25-Hydroxycholecalciferol on the Digestive and Reproductive Organ Characteristics of Commercial Layers Inoculated Before or at the Onset of Lay with the F-Strain of Mycoplasma galli

    Science.gov (United States)

    In 3 trials, the effects of dietary supple mentation with phytase (PHY) and 25-hydroxycholecalciferol (25-D3) on the digestive and reproductive organ characteristics of commercial layers that were inoculated pre-lay (12 wk of age) or at the onset of lay (22 wk of age) with F-strain Mycoplasma gallis...

  7. Use of Supplemental Short Pre-Contoured Accessory Rods and Cobalt Chrome Alloy Posterior Rods Reduces Primary Rod Strain and Range of Motion Across the Pedicle Subtraction Osteotomy Level

    DEFF Research Database (Denmark)

    Hallager, Dennis Winge; Gehrchen, Poul Martin; Dahl, Benny

    2016-01-01

    STUDY DESIGN: In vitro cadaveric biomechanical study. OBJECTIVE: To assess effects of 4-rod reconstruction, rod material, and anterior column support on motion and surface rod strain in a pedicle subtraction osteotomy model. SUMMARY OF BACKGROUND DATA: Pedicle subtraction osteotomy (PSO) can corr...

  8. Qualidade de vida de portadores de insuficiência cardíaca Calidad de vida de portadores de insuficiencia cardíaca Quality of life of heart failure patients

    Directory of Open Access Journals (Sweden)

    Djanira Alzira Soares

    2008-01-01

    Full Text Available OBJETIVO: Identificar o nível de qualidade de vida de portadores de insuficiência cardíaca; o grau de insuficiência cardíaca dos pacientes; a opinião dos portadores de insuficiência cardíaca quanto ao seu estado de saúde atual quanto comparada há um ano atrás. MÉTODOS: A amostra foi composta por 30 portadores de insuficiência cardíaca atendidos em ambulatório de um hospital geral e público do município de Taboão da Serra - SP. Para a coleta de dados foi utilizado o Medical Outcomes Study 36-item Short Form Health Survey (SF-36. RESULTADOS: Os resultados do estudo permitiram identificar o nível de qualidade de vida em diferentes dimensões: aspectos físicos (08; aspectos emocionais (09; capacidade funcional (22; estado geral da saúde (34; dor (39; aspectos sociais (40; vitalidade (47 e saúde mental (53. CONCLUSÃO: Esse estudo pode contribuir para a melhora da assistência de enfermagem prestada a portadores de insuficiência cardíaca na medida em que ressalta as limitações vivenciadas por esses indivíduos, bem como o impacto dessas limitações em seu padrão de vida normal.OBJETIVO: Identificar el nivel de calidad de vida de portadores de insuficiencia cardíaca; el grado de insuficiencia cardíaca de los pacientes; la opinión de los portadores de insuficiencia cardíaca en cuanto a su estado de salud actual en comparación al año anterior. MÉTODOS: La muestra estuvo compuesta por 30 portadores de insuficiencia cardíaca atendidos en consulta externa de un hospital general y público del municipio de Taboão da Serra - SP. Para la recolección de datos fue utilizado el Medical Outcomes Study 36-item Short Form Health Survey (SF-36. RESULTADOS: Los resultados del estudio permitieron identificar el nivel de calidad de vida en diferentes dimensiones: aspectos físicos (08; aspectos emocionales (09; capacidad funcional (22; estado general de la salud (34; dolor (39; aspectos sociales (40; vitalidad (47 y salud mental

  9. Cofinitely weak supplemented modules

    OpenAIRE

    Alizade, Rafail; Büyükaşık, Engin

    2003-01-01

    We prove that a module M is cofinitely weak supplemented or briefly cws (i.e., every submodule N of M with M/N finitely generated, has a weak supplement) if and only if every maximal submodule has a weak supplement. If M is a cws-module then every M-generated module is a cws-module. Every module is cws if and only if the ring is semilocal. We study also modules, whose finitely generated submodules have weak supplements.

  10. Acquisition through horizontal gene transfer of plasmid pSMA198 by Streptococcus macedonicus ACA-DC 198 points towards the dairy origin of the species.

    Directory of Open Access Journals (Sweden)

    Konstantinos Papadimitriou

    Full Text Available Streptococcus macedonicus is an intriguing streptococcal species whose most frequent source of isolation is fermented foods similarly to Streptococcus thermophilus. However, S. macedonicus is closely related to commensal opportunistic pathogens of the Streptococcus bovis/Streptococcus equinus complex.We analyzed the pSMA198 plasmid isolated from the dairy strain Streptococcus macedonicus ACA-DC 198 in order to provide novel clues about the main ecological niche of this bacterium. pSMA198 belongs to the narrow host range pCI305/pWV02 family found primarily in lactococci and to the best of our knowledge it is the first such plasmid to be reported in streptococci. Comparative analysis of the pSMA198 sequence revealed a high degree of similarity with plasmids isolated from Lactococcus lactis strains deriving from milk or its products. Phylogenetic analysis of the pSMA198 Rep showed that the vast majority of closely related proteins derive from lactococcal dairy isolates. Additionally, cloning of the pSMA198 ori in L. lactis revealed a 100% stability of replication over 100 generations. Both pSMA198 and the chromosome of S. macedonicus exhibit a high percentage of potential pseudogenes, indicating that they have co-evolved under the same gene decay processes. We identified chromosomal regions in S. macedonicus that may have originated from pSMA198, also supporting a long co-existence of the two replicons. pSMA198 was also found in divergent biotypes of S. macedonicus and in strains isolated from dispersed geographic locations (e.g. Greece and Switzerland showing that pSMA198's acquisition is not a recent event.Here we propose that S. macedonicus acquired plasmid pSMA198 from L. lactis via an ancestral genetic exchange event that took place most probably in milk or dairy products. We provide important evidence that point towards the dairy origin of this species.

  11. Insuficiência cardíaca: estratégias usadas por idosos na busca por qualidade de vida

    Directory of Open Access Journals (Sweden)

    Analyane Conceição Silva dos Santos

    2011-10-01

    Full Text Available Estudo descritivo com abordagem qualitativa cujos objetivos foram identificar as repercussões da insuficiência cardíaca na qualidade de vida dos idosos; descrever as estratégias utilizadas no enfrentamento destas repercussões e conhecer as percepções acerca dos cuidados de enfermagem. Foram realizadas entrevistas semiestruturadas com dez idosos com insuficiência cardíaca em um hospital militar do Rio de Janeiro-RJ. Identificou-se que a insuficiência cardíaca gera repercussões emocionais, físicas e financeiras na vida dos idosos, ocasionando impacto na qualidade de vida. Dentre as estratégias criadas pelos idosos, verificou-se o enfrentamento paliativo e o enfrentamento emocional. Os cuidados de enfermagem evidenciados foram orientação, carinho, zelo e dedicação. Cuidar do idoso com insuficiência cardíaca implica em avaliar as repercussões na capacidade funcional e autonomia dos anciãos, exigindo habilidades e competências do enfermeiro para identificar suas especificidades na perspectiva de um cuidado integral que contribua para a qualidade de vida dos mesmos.

  12. 76 FR 41262 - Notice of Intent To Award Affordable Care Act (ACA) Funding, EH11-1103

    Science.gov (United States)

    2011-07-13

    ... funding authority language will read: --This program is authorized under Section 317(k)(2) of the Public... health and help restrain the rate of growth in private and public sector health care costs.'' The ACA and... public health and environmental sectors to improve health tracking, hazard monitoring and...

  13. 76 FR 41501 - Notice of Intent To Award Affordable Care Act (ACA) Funding, EH09-907

    Science.gov (United States)

    2011-07-14

    ... submitted under funding opportunity EH09-907, ``National Environmental Public Health Tracking Program... health and help restrain the rate of growth in private and public sector health care costs.'' The ACA and... public health and environmental sectors to improve health tracking, hazard monitoring and...

  14. 76 FR 41261 - Notice of Intent To Award Affordable Care Act (ACA) Funding, EH10-1003

    Science.gov (United States)

    2011-07-13

    ... application under funding opportunity EH10-1003, ``National Environmental Public Health Tracking Program... under funding opportunity EH10-1003, ``National Environmental Public Health Tracking Program (EPHT... of growth in private and public sector health care costs.'' The ACA and the Prevention and...

  15. Variabilidade da frequência cardíaca em neonatos prematuros e de termo

    Directory of Open Access Journals (Sweden)

    Fabio Augusto Selig

    2011-06-01

    Full Text Available FUNDAMENTO: Várias publicações têm demonstrado a importância do sistema nervoso autônomo por meio dos componentes simpático e parassimpático na gerência da interação entre as diferentes partes do organismo humano. Esses estudos aplicaram técnicas lineares e não lineares (Teoria do Caos de avaliação em diferentes situações, doenças e faixas etárias, tendo como ferramenta a variabilidade da frequência cardíaca (VFC. OBJETIVO: Aplicar os conhecimentos das dinâmicas linear e não linear na avaliação de neonatos prematuros (NPT, analisando sua VFC e comparando com neonatos de termo (NT saudáveis. MÉTODOS: Quarenta e oito neonatos prematuros com diferentes idades gestacionais tiveram seus batimentos cardíacos captados com auxílio do equipamento Polar Advanced S810i e sua VFC obtida pelo registro dos intervalos RR. A VFC foi analisada nos domínios do tempo (SDNN, RMSSD, SD1/SD2, da frequência (VLF, LF, HF e a relação LF/HF e do caos (TAU e sua normalização [TAU(n], Expoente de Lyapunov e Entropia. Os NPT foram comparados com um grupo de 78 NT saudáveis e sem intercorrências perinatais com auxílio do teste não paramétrico de Kruskal-Wallis. RESULTADOS: Detectou-se diferença estatisticamente significante entre os grupos para todas as variáveis estudadas, tanto no domínio do tempo como nos da frequência e do caos. CONCLUSÃO: Neonatos prematuros exibem comportamento menos complexo da variabilidade da frequência cardíaca que neonatos de termo, fato comprovado nos domínios do tempo, da frequência e do caos. O estudo da variabilidade cardíaca nesse grupo pode ser considerado uma ferramenta a mais na avaliação da maturação autonômica e, consequentemente, da progressão para eutrofia.

  16. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models

    Science.gov (United States)

    Coroniti, Roberta; Fario, Rafal; Nuno, Didier J.; Otvos, Laszlo; Scolaro, Laura; Surmacz, Eva

    2016-01-01

    Experimental and clinical data suggest that pro-angiogenic, pro-inflammatory and mitogenic cytokine leptin can be implicated in ocular neovascularization and other eye pathologies. At least in part, leptin action appears to be mediated through functional interplay with vascular endothelial growth factor (VEGF). VEGF is a potent regulator of neoangiogenesis and vascular leakage with a proven role in conditions such as proliferative diabetic retinopathy, age-related macular degeneration and diabetic macular edema. Accordingly, drugs targeting VEGF are becoming mainstream treatments for these diseases. The crosstalk between leptin and VEGF has been noted in different tissues, but its involvement in the development of eye pathologies is unclear. Leptin is coexpressed with VEGF during ocular neovascularization and can potentiate VEGF synthesis and angiogenic function. However, whether or not VEGF regulates leptin expression or signaling has never been studied. Consequently, we addressed this aspect of leptin/VEGF crosstalk in ocular models, focusing on therapeutic exploration of underlying mechanisms. Here we show, for the first time, that in retinal (RF/6A) and corneal (BCE) endothelial cells, VEGF (100 ng/mL, 24 h) stimulated leptin mRNA synthesis by 70 and 30%, respectively, and protein expression by 56 and 28%, respectively. In parallel, VEGF induced RF/6A and BCE cell growth by 33 and 20%, respectively. In addition, VEGF upregulated chemotaxis and chemokinesis in retinal cells by ~40%. VEGF-dependent proliferation and migration were significantly reduced in the presence of the leptin receptor antagonist, Allo-aca, at 100–250 nmol/L concentrations. Furthermore, Allo-aca suppressed VEGF-dependent long-term (24 h), but not acute (15 min) stimulation of the Akt and ERK1/2 signaling pathways. The efficacy of Allo-aca was validated in the rat laser-induced choroidal neovascularization model where the compound (5 μg/eye) significantly reduced pathological

  17. Ressincronização cardíaca e terapia celular: existe terapia associativa?

    Directory of Open Access Journals (Sweden)

    Oswaldo T. Greco

    Full Text Available Nos últimos anos, a terapia de ressincronização cardíaca tem sido uma conduta bem definida para pacientes com insuficiência cardíaca (IC, classe funcional III ou IV, que não tiveram resposta à otimização terapêutica. Estudos já mostraram esta eficácia, mas um grupo bem definido de miocardiopatias dilatadas com áreas de fibrose não tem tido o mesmo sucesso (30%-40%. Por isto decidimos associar a estes pacientes o implante de células-tronco. A partir de 04/2005 iniciamos estes implantes em pacientes (pcs. com IC, classe funcional III/IV, otmizados e fração de ejeção <35% com dissincronia ventricular. Total de 25 pacientes (16 homens, idade entre 30-80anos (média de 58 e 44% de etiologia chagásica (11 pcs. Ressincronização e terapia celular foram por via epicárdica (12 pcs e endocárdica (13 pcs e a seleção celular pela filtração por Ficoll e 3.0x10(8 de células infundidas CD34 + (5,0 x 10(6 e CD 133 + (2,5 x 10(6. Após 24 meses de evolução observamos que 84,8% destes pcs permaneceram vivos e a mortalidade (15,2% não estava relacionada ao procedimento. A sobrevida dos portadores de marcapasso foi maior (52,4% e os chagásicos tiveram uma pior sobrevida, mas com teste de long-rank de 0,218 e 0,626, respectivamente. Nos casos de pcs com ressincronizador isoladamente, os resultados não parecem ser tão bons,e nós optamos pela associação de células-tronco como uma alternativa segura e adequada para estes graves pcs com insuficiência cardíaca e miocardiopatia dilatada.

  18. Trombocitopenia adquirida e cirurgia cardíaca: relato de caso

    Directory of Open Access Journals (Sweden)

    GIFFHORN Hélcio

    2002-01-01

    Full Text Available Trombocitopenia é um grande problema hemostático em pacientes submetidos à cirurgia cardíaca. Relataremos dois casos de pacientes com diminuição adquirida das plaquetas: um devido a uremia e outro por disfunção valvar (disfunção de prótese em posição mitral. Estes pacientes tiveram períodos de transoperatório e pós-operatório imediato sem intercorrência. A perda sangüínea não foi maior do que a esperada. A transfusão de plaquetas realizada durante a operação pode prevenir futuras complicações na recuperação do paciente.

  19. Grupo de pacientes de cirurgia cardíaca: relato de experiência

    Directory of Open Access Journals (Sweden)

    Elisa Helena Kuhn

    1986-09-01

    Full Text Available Neste trabalho relata-se uma experiência de grupo com pacientes de cirurgia cardíaca. A atividade realiza-se no INSTITUTO DE CARDIOLOGIA DO RIO GRANDE DO SUL e tem por objetivo proporcionar aos pacientes a oportunidade de verbalizarem suas ansiedades e conversarem sobre suas experiências relacionadas com a cirurgia e anestesia. Os grupos reúnem-se duas vezes por semana sendo constituídos por pacientes adultos em pré e pós-operatório imediato. A equipe de saúde é composta por enfermeiros, psicólogo, anestesista, cardiologistas e fisioterapeutas e sua atuação é no sentido de auxiliar na compreensão dos procedimentos aos quais o paciente vai se submeter, desfazendo fantasias distorcidas da realidade.

  20. Proteção miocárdica em cirurgia cardíaca

    OpenAIRE

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: A proteção miocárdica define o conjunto de estratégias que objetivam atenuar a intensidade da lesão de isquemia-reperfusão miocárdica durante a cirurgia cardíaca e suas conseqüências sobre a função miocárdica. Um melhor entendimento dos fenômenos fisiopatológicos relacionados à isquemia-reperfusão miocárdica e da cardioproteção promovida por determinados fármacos e técnicas anestésicas tem dado ao anestesiologista papel importante na proteção miocárdica durante o pr...

  1. The management of esotropia with high AC/A ratio (convergence excess).

    Science.gov (United States)

    Pratt-Johnson, J A; Tillson, G

    1985-01-01

    This paper reviews the long-term follow-up of esotropia with a high AC/A ratio defined as an increase of 20 delta or more of the esotropia at near compared with distance with the full optical correction of any refractive error in place. Ninety-nine patients were studied for an average follow-up of eight years. Eighty-six achieved fusion but only five achieved central fusion. Forty-five were treated with bifocals. No significant difference in the sensory results were recorded in those patients wearing bifocals compared with those who did not wear bifocals. No patient had miotic therapy for more than a few months. The suppression characteristic of this condition is reviewed.

  2. Manejo nutricional de la enfermedad celíaca Nutritional management of the celiac disease

    Directory of Open Access Journals (Sweden)

    Daris I. González Hernández

    2006-06-01

    Full Text Available La enfermedad celíaca es una causa importante de malaabsorción en la niñez. Se caracteriza por una intolerancia total y permanente al gluten que contiene la fracción proteica del trigo y otros cereales. La patogenia de la enfermedad es multifactorial y tiene un cuadro clínico variado, en el cual predominan los síntomas de malaabsorción y la desnutrición. La dieta exenta de gluten es la parte más importante de la terapéutica, además de hacer frente a las deficiencias nutricionales. Se hace una revisión del manejo dietético y la educación nutricional del paciente y sus familiares, con énfasis en los alimentos que pueden contener gluten de forma enmascarada.

  3. Manifestaciones digestivas y extradigestivas de la enfermedad celíaca.

    OpenAIRE

    Luis Ortigosa

    2009-01-01

    La enfermedad celíaca (EC) es una enteropatía de base autoinmune que se manifiesta en sujetos genéticamente susceptibles, asociada con genes que codifican para las moléculas HLA DQ2 (DQ A1*0501/DQB1*0201) y DQ8 (DQA1*0301/ DQB1*0302). Se caracteriza por una respuesta inmunológica a la ingesta del gluten de trigo y otras prolaminas relacionadas del centeno y la cebada. Las manifestaciones clínicas son diversas, puede haber formas sintomáticas digestivas “clásicas” en niños, y formas extradiges...

  4. Disfunção cognitiva após cirurgia cardíaca

    OpenAIRE

    Martin,José Fernando Vilela; Melo,Renan Oliveira Vaz de; Sousa,Letícia Pinheiro de

    2008-01-01

    Disfunção cognitiva pós-operatória é situação freqüente em cirurgias cardíacas, o que pode levar a conseqüências imensuráveis para os indivíduos acometidos. Os processos fisiopatológicos envolvidos nessa condição ainda não se encontram totalmente elucidados, apresentando um caráter multifatorial. Além de fatores pré-operatórios, como idade e escolaridade, alguns fatores intra-operatórios também são de extrema importância. Entretanto, conforme ampla literatura sobre o tema, esses fatores não s...

  5. Estudo da variabilidade da frequência cardíaca em cães

    OpenAIRE

    PASCON, João Paulo da Exaltação

    2009-01-01

    A avaliação da variabilidade da frequência cardíaca (VFC) possibilita quantificar a participação do sistema nervoso autônomo simpático e parassimpático. Clinicamente, esta relaciona-se com o prognóstico e risco de morte súbita em diversas afecções no homem, mas ainda permanece incerta em importantes enfermidades caninas como a degeneração mixomatosa valvar e obesidade. Dentre as alternativas terapêuticas capazes de modificar o balanço autonômico de forma benéfica, o exercício físico se destac...

  6. Caquexia associada à insuficiência cardíaca Heart failure-induced cachexia

    Directory of Open Access Journals (Sweden)

    Marina Politi Okoshi

    2013-05-01

    Full Text Available Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e alteração da relação entre processos anabólicos e catabólicos. Como não há terapia específica para a caquexia associada à insuficiência cardíaca, o tratamento baseia-se no suporte nutricional, bloqueio neuro-hormonal, controle do edema e anemia e exercícios físicos. Fármacos com propriedades imunomodulatórias e anabólicas encontram-se em investigação clínica e experimental.Heart failure patients often develop cachexia, which is an independent factor for survival reduction. Cachexia can be diagnosed when there is loss of more than 6% of the body weight, in the absence of other diseases. Even though its pathophysiology has not yet been completely clarified, various factors seem to be involved, such as reduction in food consumption, gastrointestinal tract abnormalities, immunologic and neuro-hormonal activarion and changes in the relationship between anabolic and catabolic processes. Since there is not specific therapy for heart failure-induced cachexia, management is based on nutritional support, neuro-hormonal blockade, control of edema and anemia and exercise. Drugs with anabolic and immunomodulating properties are being evaluated and clinical and non-clinical trials.

  7. Suporte social para idosos portadores de insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    B. M.O. Santos

    2009-01-01

    Full Text Available

    O objetivo do presente estudo foi identificar a existência de suporte social em 20 idosos portadores de Insuficiência Cardíaca (IC internados em um hospital especializado de cidade do interior paulista. Os dados foram obtidos através de entrevista individual utilizando o modelo Canadian Social Support Inventory for People who are Positive or Have Aids, validado no Brasil em 2001 e adaptado para o foco do estudo. O referido instrumento é constituído de duas dimensões de suporte social, instrumental e emocional, com seus respectivos itens e subitens. A análise dos dados foi realizada por meio da estatística descritiva e análise de correlação cruzada (cross correlation. A correlação das variáveis foi dada pelo coeficiente de correlação de Pearson e o nível de significância adotado foi p≤0,05. Os resultados permitiram a caracterização dos idosos e a manifestação de que ainda que recebam pouco suporte social, tanto na dimensão instrumental, como na emocional, manifestaram-se satisfeitos ou muito satisfeitos com o pouco apoio recebido. O referido suporte é oferecido por familiares, amigos e até vizinhos, com pouca expressividade por parte dos profissionais de saúde e praticamente inexistente por parte de chefes e/ou colegas de trabalho. Palavras-chave: insuficiência cardíaca; suporte social; idoso; qualidade de vida.

  8. Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals

    National Research Council Canada - National Science Library

    Wang, S; Zhu, H; Lu, C; Kang, Z; Luo, Y; Feng, L; Lu, X

    2012-01-01

    Fermented milk supplemented with 2 probiotic strains, Bifidobacterium lactis Bi-07 and Lactobacillus acidophilus NCFM, and a prebiotic, isomaltooligosaccharide, was orally administered to 100 healthy...

  9. Aporte de la frecuencia cardíaca en futbolistas durante el período de competencia

    Directory of Open Access Journals (Sweden)

    Arnaldo A. Angelino

    2009-01-01

    Full Text Available ObjetivosEvaluar el comportamiento de los componentes de la curva dinámica de la frecuencia cardíaca basal, intraesfuerzo y de recuperación de acuerdo con el tiempo, la distancia y la intensidad de pruebas aeróbicas en cinta ergométrica y de campo como indicador de entrenamiento y adaptación física durante el período de competencia en jugadores de fútbol.Material y métodosSe evaluaron 108 jugadores de fútbol juvenil, masculinos y de 17 ± 2 años, con prueba aeróbica ergométrica y de campo durante el ciclo competitivo. Se realizó prueba de 2.400 metros en cinta ergométrica y Yo-Yo Test en campo (Endurance nivel 2.ResultadosEl registro continuo de frecuencia cardíaca permitió observar: 1 un registro más detallado de las modificaciones de la frecuencia cardíaca submáxima (89,4 ± 7,6 versus 83,0 ± 7,7; p < 0,05 en cinta ergométrica, 2 diferentes respuestas de frecuencia cardíaca submáxima en prueba ergométrica y de campo al primer minuto (164,0 versus 116,6; p < 0,05 y al segundo minuto (176,3 versus 123,5; p < 0,05 en relación con la frecuencia cardíaca máxima (198,6 versus 194,0; p = ns, 3 en pruebas de campo se observó un intervalo mayor de reserva de frecuencia cardíaca en relación con la capacidad de resistencia a partir del segundo minuto (25,9 versus 19,1; p < 0,05.ConclusionesEl registro comparativo de la frecuencia cardíaca durante el ciclo competitivo en jugadores de fútbol en pruebas aeróbicas ergométricas y en prueba de campo permite el análisis de indicadores de entrenamiento y adaptación física. Los indicadores de frecuencia cardíaca basal, submáxima, máxima, de recuperación e intervalo de reserva de frecuencia cardíaca permiten información de rendimiento y entrenamiento en la resistencia a diferente velocidad de desplazamiento, tiempo de permanencia y distancia en pruebas de cinta ergométrica y de campo, de gran utilidad para las pautas de entrenamiento durante el período de competencia

  10. Comportamento dos quimiorreflexos central e periférico na insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Guilherme Veiga Guimarães

    2011-02-01

    Full Text Available A síndrome da insuficiência cardíaca (IC pode ser definida como via final de qualquer forma de doença cardíaca. Os reflexos cardiovasculares simpatoinibitórios como o reflexo arterial barorreceptor estão significativamente suprimidos na IC. Pacientes com IC apresentam maior ventilação para determinada carga de trabalho quando comparados a indivíduos normais. Esse fato gera baixa eficiência ventilatória e relaciona-se com maior ventilação relativa à produção de gás carbônico, que é um preditor de mau prognóstico, além de ser um fator limitante ao exercício. Há evidências de que o desequilíbrio autonômico contribua para a patogênese e a progressão da insuficiência cardíaca. Os quimiorreflexos são os principais mecanismos de controle e regulação das respostas ventilatórias às mudanças de concentração do oxigênio e gás carbônico arterial. A ativação do quimiorreflexo causa aumento da atividade simpática, frequência cardíaca, pressão arterial e volume minuto. No entanto, o aumento do volume minuto e da pressão arterial, pelo feedback negativo provocam inibição da resposta simpática à ativação do quimiorreflexo. Apesar das alterações funcionais dos reflexos, seu comportamento em condições normais e patológicas, especialmente sua contribuição para o estado simpatoexcitatório encontrado na IC, não tem sido amplamente estudado. Dessa forma, esta revisão tem por objetivo integrar os conhecimentos a respeito dos quimiorreflexos central e periférico na síndrome da insuficiência cardíaca, bem como esclarecer a influência da terapêutica medicamentosa da insuficiência cardíaca nos quimiorreflexos.

  11. La bomba de succión cardíaca. Aplicación de la banda miocárdica de Torrent Guasp al tratamiento quirúrgico de la insuficiencia cardíaca

    OpenAIRE

    Jorge Carlos Trainini; Jesús Herreros; Javier Cabo; Eduardo Otero Coto; Juan Cosín-Aguilar

    2011-01-01

    El modelo clásico de función cardíaca ha sido asumido durante décadas. Este modelo está basado en la ley de Frank-starling, enunciado con corazones extirpados. La hipótesis de Torrent-Guasp ha conseguido que el estudio de la acción mecánica cardíaca recupere la importancia que le corresponde. Esta hipótesis ha llevado a revisar conceptos clásicos tales como que la banda mio-cárdica sería generadora de la reducción tridimensional, que la unidad morfológica de las aurículas y ventrículos contra...

  12. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers

    Directory of Open Access Journals (Sweden)

    Alex Galanis

    2015-10-01

    Full Text Available Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers derived from Random Amplified Polymorphic DNA (RAPD Sequenced Characterized Amplified Region (SCAR analysis. The specificity of the assay was tested with a total of 23 different LAB strains, for L. plantarum 2035 and L. plantarum ACA-DC 2640. The multiplex PCR assay was also successfully applied for the detection of the above cultures in yogurt samples prepared in our lab. The proposed methodology may be applied for monitoring the presence of these strains in food products, thus evaluating their probiotic character. Moreover, our strategy may be adapted for other novel LAB strains with probiotic potential, thus providing a powerful tool for molecular discrimination that could be invaluable to the food industry.

  13. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers.

    Science.gov (United States)

    Galanis, Alex; Kourkoutas, Yiannis; Tassou, Chrysoula C; Chorianopoulos, Nikos

    2015-10-22

    Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB) strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers derived from Random Amplified Polymorphic DNA (RAPD) Sequenced Characterized Amplified Region (SCAR) analysis. The specificity of the assay was tested with a total of 23 different LAB strains, for L. plantarum 2035 and L. plantarum ACA-DC 2640. The multiplex PCR assay was also successfully applied for the detection of the above cultures in yogurt samples prepared in our lab. The proposed methodology may be applied for monitoring the presence of these strains in food products, thus evaluating their probiotic character. Moreover, our strategy may be adapted for other novel LAB strains with probiotic potential, thus providing a powerful tool for molecular discrimination that could be invaluable to the food industry.

  14. The status of probiotics supplementation during pregnancy

    Directory of Open Access Journals (Sweden)

    Noroyono Wibowo

    2015-07-01

    Full Text Available Probiotics have been known for their use in medical field for quite a long time. Strong evidences are now available for the use of probiotics in clinical setting. One of the current issues on this topic is the use of probiotics in pregnancy. Recent studies showed that probiotics may be safe and beneficial for prenatal supplementation. In this review, we highlighted several proven use of probiotics supplementation in pregnant women. A few selected strains of probiotics showed promising outcome to prevent preterm labor and preeclampsia, and to reduce atopic eczema but not asthma and wheezing, in offspring of women who had prenatal probiotics supplementation. The mechanism of action responsible for this effect is closely related to the regulation of T cells, although the exact pathways are not defined yet.

  15. Lesões cardíacas em ratos wistar inoculados com diferentes cepas do Trypanosoma cruzi

    Directory of Open Access Journals (Sweden)

    E. Chapadeiro

    1988-09-01

    Full Text Available Ratos albinos Wistar infectados com diferentes inóculos das cepas Y, Colombiana (COL e São Felipe (12SF do Trypanosoma cruzi desenvolveram parasitemia elevada entre 14e21 dias, a qual tomou-se desprezível ou desapareceu completamente ao final da 4ª semana. As lesões do coração foram avaliadas, semiquantitativamente, pelo sistema de "scores", conforme a intensidade e a extensão da inflamação, nas diferentes estruturas do órgão, tendo sido observado que: a na fase inicial (aguda da infecção, os animais mortos espontaneamente ou em conseqüência de acidente anestésico apresentaram cardite de intensidade moderada à acentuada, não havendo diferença em relação às cepas utilizadas; as diferentes estruturas do coração estavam uniformemente comprometidas; b na fase crônica da infecção observou-se cardite degrau leve a moderado e as lesões foram mais freqüentes e intensas quanto maior o inoculo empregado; no entanto, inóculos baixos só produziram lesões quando a cepa utilizada foi a Colombiana. Trombose mural nos átrios e dilatação da ponta do ventrículo esquerdo foram observadas em 20% dos animais, independentemente da cepa. Na fase crônica 15% dos animais apresentaram miocardite crônica com fibrose, associada à hipertrofia das miocélulas. Os AA confirmam ser o rato albino suscetível à infecção chagásica e, portanto, um modelo útil no estudo das manifestações cardíacas da Doença de Chagas.Wistar albino rats infected intraperitonially with different inocula of Y, 12SF and Colombian strains of Trypanosoma cruzi developed high parasitemia, which lowered by the end of the 6th week; mortality varied according with the strain and inoculum. Acute carditis like that occurring in the human, was found in all animals killed or dying spontaneously. The surviving rats were sacrificed in the 8th month of infection. They presented active chronic carditis involving especially the myocardium and the intracardiac nervous

  16. Style as Supplement - Supplement as Style

    DEFF Research Database (Denmark)

    Sørensen, Bent

    The film Derrida by Amy Ziering Kofman & Kirby Dick (2003) has a memorable scene, showing Derrida watching Derrida watching Derrida. This regression, almost ad infinitum, would seem to have the specific purpose to hammer home the point to the viewer of the film that all communication is mediated......, and to aim for an almost Brechtian Verfremdung-effect, but the film also uses this device as a stylistic trait to characterize something ‘essential' about Derrida and his style. Derrida strikes the same chord by insisting on drawing attention to the artificiality of the making of the film, where questions...... and deferrals. This is of course another link in the infinite Derridean chain of supplements to supplements of supplements - in his writings, his persona and the legacy of images of him left behind in the archives. How does this perpetual deferral reflect itself in Derrida's visual and verbal style...

  17. Differentiation of Listeria and Streptococcus strains.

    Science.gov (United States)

    Herendi, A; Ralovich, B

    1989-01-01

    Colonial morphology of non-beta haemolytic Listeria strains is frequently similar to that of non-haemolytic streptococci. Biochemical characteristics, motility, haemolysis on ox blood agar, growth on Clauberg, selective streptococcus (Si) and Mitis-Salivarius agar medium, CAMP test, serological behaviour of 16 Listeria strains were studied and the results were compared with the properties of Streptococcus strains. Microscopic morphology, motility and catalase activity are useful for distinguishing these strains. To avoid a false diagnosis, latex-agglutination should be supplemented with the above tests.

  18. Los excerpta de Beda (De Temporum Ratione 19 y 23 en Ripoll (ACA, Ripoll 59 y Vat. Reg. Lat. 123

    Directory of Open Access Journals (Sweden)

    José Martínez Gázquez

    1996-12-01

    Full Text Available The analysis of texts and glossaries contained in the manuscript ACA Ripoll 59 reveals various compilations of glossaries and «computation» texts, besides Priscian's grammar, which is the most important text in the manuscript. The analysis and identification of the fragments in ACA Ripoll 59 the same as those in Vat. Reg. Lat. 123, which also belongs to the manuscripts found in Ripoll, corresponding to various chapters of Beda, allow us to study the different currents that exerted their cultural influence in the Monastery of Santa Maria de Ripoll. Through the variants established for each of the texts that have been identified, one detects the influence of various families of manuscripts in the composition of these fragments.

  19. Realidad de la cirugía cardíaca en la República Argentina. Registro CONAREC XVI

    OpenAIRE

    Diego M. Lowenstein Haber; Fernando M. Guardiani; Pablo Pieroni; Lisandro Pfister; Laura Carrizo; Esteban D. Villegas; María F. Renedo; Federico J. Landeta; Jorge Thierer

    2010-01-01

    RESUMENIntroducciónLos dos grandes registros multicéntricos de cirugía cardíaca realizados en la Argentina,CONAREC y ESMUCICA, datan de más de 10 años. Considerando los avances médicosy quirúrgicos de la última década, surgió la necesidad de realizar un nuevo registronacional, prospectivo y multicéntrico para conocer las características, la evolución, lascomplicaciones y los predictores de mortalidad de los pacientes sometidos a cirugía cardíaca.ObjetivosConocer el perfil epidemiológico, la m...

  20. Treinamento físico na distrofia muscular de becker associada à insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Jean Marcelo Roque

    2011-12-01

    Full Text Available A distrofia muscular de Becker (DMB integra as distrofinopatias que ocorrem devido a mutações genéticas que expressam a proteína distrofina no cromossomo X. O início dos sintomas neuromusculares normalmente precede o comprometimento da função cardíaca, podendo acontecer inversamente pela insuficiência cardíaca (IC. O treinamento físico é bem estabelecido na IC, porém, quando associada à DMB, é controverso e sem fundamento científico. Apresentamos o caso de um paciente com DMB associada à IC em fila de transplante cardíaco submetido a um programa de treinamento físico.

  1. Functional and structural impact of target uridine substitutions on the H/ACA ribonucleoprotein particle pseudouridine synthase.

    Science.gov (United States)

    Zhou, Jing; Liang, Bo; Li, Hong

    2010-07-27

    Box H/ACA ribonucleoprotein protein particles catalyze the majority of pseudouridylation in functional RNA. Different from stand alone pseudouridine synthases, the RNP pseudouridine synthase comprises multiple protein subunits and an RNA subunit. Previous studies showed that each subunit, regardless its location, is sensitive to the step of subunit placement at the catalytic center and potentially to the reaction status of the substrate. Here we describe the impact of chemical substitutions of target uridine on enzyme activity and structure. We found that 3-methyluridine in place of uridine inhibited its isomerization while 2'-deoxyuridine or 4-thiouridine did not. Significantly, crystal structures of an archaeal box H/ACA RNP bound with the nonreactive and the two postreactive substrate analogues showed only subtle structural changes throughout the assembly except for a conserved tyrosine and a substrate anchoring loop of Cbf5. Our results suggest a potential role of these elements and the subunit that contacts them in substrate binding and product release.

  2. Doença celíaca é super-representada em pacientes com constipação

    OpenAIRE

    Pelleboer,Rolf A. A.; Janssen,Rob L. H.; Deckers-Kocken,Judith M.; Edward Wouters; Nissen,Annemieke C.; Bolz,Werner E. A.; Walther E. Tjon A. Ten; Cathelijne van der Feen; Oosterhuis,Koen J.; Mechelien H. Rövekamp; Nikkels, Peter G J; Houwen, Roderick H. J.

    2012-01-01

    OBJETIVO: Tem sido sugerido que pacientes com constipação sejam triados para doença celíaca. Da mesma forma, recomenda-se a investigação desses pacientes para hipotiroidismo e hipercalcemia. Contudo, nenhuma evidência para essas recomendações está disponível até o momento. Assim, propusemos-nos determinar a prevalência de doença celíaca, hipotiroidismo e hipercalcemia em crianças com constipação. MÉTODOS: Estudo de coorte prospectivo com 370 pacientes consecutivos que preencheram os critérios...

  3. Comportamento dos quimiorreflexos central e periférico na insuficiência cardíaca

    OpenAIRE

    Guilherme Veiga Guimarães; Juliana Fernanda Canhadas Belli; Fernando Bacal; Edimar Alcides Bocchi

    2011-01-01

    A síndrome da insuficiência cardíaca (IC) pode ser definida como via final de qualquer forma de doença cardíaca. Os reflexos cardiovasculares simpatoinibitórios como o reflexo arterial barorreceptor estão significativamente suprimidos na IC. Pacientes com IC apresentam maior ventilação para determinada carga de trabalho quando comparados a indivíduos normais. Esse fato gera baixa eficiência ventilatória e relaciona-se com maior ventilação relativa à produção de gás carbônico, que é um predito...

  4. Metabolismo energético mitocondrial e cardiomiogênese para regeneração cardíaca

    OpenAIRE

    2016-01-01

    Apesar dos avanços dos últimos anos, a reposição de cardiomiócitos permanece como um dos maiores desafios da medicina regenerativa. A comprovação da existência de mecanismos endógenos de proliferação cardíaca nos impulsionou a buscar o entendimento dos eventos moleculares envolvidos na proliferação de cardiomiócitos na vida pós-natal. Neste trabalho foi testada a hipótese da influência do metabolismo energético mitocondrial na cardiomiogênese, e seu impacto na regeneração cardíaca. No primeir...

  5. Comportamento do ergorreflexo na insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Juliana Fernanda Canhadas Belli

    2011-08-01

    Full Text Available Grande número de evidências tem sugerido a existência de uma rede de reflexos que se tornam hiperativos secundariamente a alterações músculo-esqueléticas que ocorrem na síndrome insuficiência cardíaca (IC. Estes, aliados aos reflexos cardiovasculares simpato-inibitórios, suprimidos na síndrome, podem contribuir para a intolerância ao exercício físico. A hiperativação dos sinais originados dos receptores localizados nos músculos esqueléticos (mecanoceptores - metaborreceptores é uma hipótese proposta recentemente para explicar a origem dos sintomas de fadiga e dispneia e os efeitos benéficos do treinamento físico na síndrome da IC. Na IC, outras alterações nos sistemas de controle reflexo, que não são mutuamente exclusivos, contribuem para dispneia. Estimulação inapropriada dos barorreceptores arteriais com consequente falta de inibição da descarga do metaborreflexo muscular e quimiorreflexo carotídeo e aumento da vasoconstricção renal com liberação de angiotensina II pode também ser considerada. Apesar das alterações funcionais dos reflexos terem sido usadas de maneira independente para ilustrar a excitação simpática observada na IC, a interação entre esses reflexos em condições normais e patológicas, especialmente sua contribuição para o estado simpato-excitatório encontrado na IC, não tem sido amplamente estudados. Assim, o problema se ambos os receptores musculares (mecano e metaborreceptores estão envolvidos na gênese da exacerbação do ergorreflexo observado na IC ainda fica a ser resolvido. Dessa forma, essa revisão tem por objetivo integrar os conhecimentos a respeito do mecano e metaborreflexo (ergorreflexo na síndrome da insuficiência cardíaca bem como esclarecer a influência da terapêutica medicamentosa da IC no ergorreflexo.

  6. Contusión cardíaca: Informe de 4 casos

    Directory of Open Access Journals (Sweden)

    Andrés Cazau Cuervo

    1997-04-01

    Full Text Available Se presentaron 4 pacientes del sexo masculino (historias clínicas números 767 451, 898 039, 606 959 y 780 349, con antecedentes, hallazgos físicos y métodos diagnósticos positivos de contusión cardíaca, los cuales fueron atendidos en el Centro de Urgencias del Hospital (Instituto Superior de Medicina Militar "Luis Díaz Soto" entre el 25 de octubre de 1989 y el 12 de febrero de 1990. El paciente más joven tenía 18 años y el más viejo 64. Los 4 pacientes presentaron síntomas variables de contusión cardíaca. El dolor retroesternal fue la manifestación clínica más constante. De los métodos utilizados para el diagnóstico, las alteraciones del segmento ST y de la onda T en los electrocardiogramas y la elevación en el suero de la fracción MB de la creatina fosfoquinasa por encima del 5 % fueron los elementos de mayor valor para el diagnóstico. Los indicadores pronósticos fueron de 20 en los casos 1, 2 y 3 (severo sin peligro de muerte y en el cuarto fue de 34 (severo con peligro de muerte. Todos los enfermos evolucionaron favorablementeFour male patients (medical records 767 451, 898 039, 606 959, and 780 349 presenting with clinical histories, physical findings, and positive diagnostic methods evidencing a cardiac contusion were attended at the Emergency Department of "Luis Díaz Soto" Higher Institute of Military Medicine between October 25, 1989 and February 12, 1990. The youngest patients was 18 years old and the oldest 64 years old. The four patients presented with different symptoms suggesting a cardiac contusion. The retrosternal pain was the principal clinical manifestation. From the methods used for the diagnosis, alterations of the ST segment and of the T wave in the electrocardiograms and the rise in serum MB fraction of creatine phosphokinase above 5 % were found to be the most useful elements for the diagnosis. The prognostic indicators were 20 in cases 1, 2, and 3 (severe with no risk of death and in case 4 were 34

  7. 一种新的混合并行蚁群算法研究应用%Research on a new hybrid parallel ACA

    Institute of Scientific and Technical Information of China (English)

    王磊

    2012-01-01

    提出了一种新的混合并行蚁群算法,在单机多核机及多核集群机下分别实现了MPI并行蚁群算法及MPI+ TBB并行蚁群算法,应用于真实路网车辆路径问题(Vehicle Routing Problem,VRP),对两者进行了实验对比,实验结果表明MPI并行蚁群算法具有较高的加速比,和问题规模关系不大,刚开始呈现线性加速比.较MPI并行蚁群算法,MPI+ TBB混合并行蚁群算法具有更好的可扩展性,在进程数较多时仍具有较高的加速比.%A new hybrid parallel ant colony algorithm (ACA) is presented, respectively construct MPI parallel ACA and MPI + TBB parallel ACA in the multi-core single machine and multi-core clusters to apply to the real road network for vehicle routing problem ( VRP). The experimental results show that MPI based parallel ACA make higher speedup , have nothing to do with problem size, and show linear speedup at the beginning. MPI + TBB based parallel hybrid parallel ACA has better scalability and a more high speedup than the MPI based parallel ACA in the more processes.

  8. Seguridad del paciente en el postoperatorio de cirugía cardíaca en UCI

    OpenAIRE

    Álvarez Menéndez, Katia

    2013-01-01

    Describir las medidas de seguridad del paciente que se adoptan en el postoperatorio de cirugía cardíaca en UCI y comprobar que dichas medidas de seguridad del paciente son efectivas y proporcionan beneficios a los pacientes. Para ello se describen todos los protocolos y dispositivos específicos y se comparan los resultados obtenidos en cuanto a los protocolos de Neumonía Zero y Bacteriemia Zero.

  9. FERMENTATION EFFICIENCY OF YEAST ISOLATES AND THE EFECT OF NUTRIENT SUPPLEMENTS

    Directory of Open Access Journals (Sweden)

    HELEN SOIBAM1, AYAM VICTOR SINGH2, IVI CHAKRABORTY3

    2014-12-01

    Full Text Available ABSTRACT: Wine is one of the end products of fermentation of respiratory substrates, while, yeast is one of the principal fermenting microorganisms. Changes in the substrate composition and yeast strains could vary in the quality of the wine. Two yeast isolates (Y4 and Y7 from date palm juice and standard yeast “Y33”,an isolate of Saccharomyces cerevisiae (MTCC-170 from Institute of MicrobiAl Technology, IMTECH, Chandigarh where used for studying the comparative fermentation of Molasses without nutrient supplementation, and separately with nutrient supplementation by KH2PO4 and NaNO3 @ 1g/l. Though, with nutrient supplement KH2PO4, Y33 yields higher alcohol%, both Y4 and Y7 strains produce wine with better efficiency and acceptability without the nutrient supplements unlike Y33 strains. All the three strains impart better flavour and colour in the medium without nutrient supplement in terms of hedonic scale. Further, Y4 yields higher alcohol than Y7 and Y33. Therefore, palm juice yeast isolates particularly, Y4 strains show the highest overall fermentation efficiency and acceptability among the three yeasts isolates, moreover, since its highest efficiency occurs in the absence of nutrient supplementation, unlike the standard strain, it can be recommendedas a better substitute of the standard Y33 strains. KEY WORDS: Fermentation, Yeast,  Nutrient supplements.

  10. 头孢匹胺中间体7-ACA-MMTZ的合成工艺研究

    Institute of Scientific and Technical Information of China (English)

    殷福东; 姜福元; 卢言建

    2008-01-01

    对弱碱催化法合成7-ACA-MMTZ的工艺进行了探索,在现有文献基础上对弱碱催化法进行工艺改进,加入了相转移催化剂TEBA,同时通过正交试验找到了理想的反应条件,使产品纯度达93%以上、收率达到83%.与文献报道相比均有所提高.在现有文献的基础上,确定了以7-ACA为原料,在三氟化硼催化下,与1-甲基-5-巯基四氮唑发生缩合反应,制备头孢母核7-ACA-MMTZ的方法.通过正交试验,找到了理想的反应条件,通过实验发现较理想的反应条件是:催化剂是三氟化硼-乙腈,反应温度20-30℃,反应时间150min,配料比1:1.2(摩尔比).使7-ACA-MMTZ合成总收率达105%(重量收率),产品质量明显提高.

  11. Muerte súbita por conmoción cardíaca (Commotio cordis asociada a miocardio no compactado

    Directory of Open Access Journals (Sweden)

    Analía Aquieri

    2011-12-01

    Full Text Available El miocardio no compactado es una rara miocardiopatía congénita caracterizada por la presencia de múltiples y prominentes trabeculaciones profundas en la pared ventricular que definen hendiduras comunicantes con el compartimiento ventricular principal. Es una entidad de baja incidencia y prevalencia que se diagnostica mediante estudios de imágenes como el ecocardiograma Doppler (ED, la tomografía computarizada multicorte (TCM y la resonancia magnética cardíaca (RMC. Puede ser asintomática o manifestarse mediante arritmias, insuficiencia cardíaca o eventos tromboembólicos. Se presenta el caso de un hombre de 33 años, asintomático, que durante la práctica deportiva sufre una conmoción cardíaca (commotio cordis que le produce un paro cardiorrespiratorio. El electrocardiograma mostró un ritmo de aleteo ventricular que requirió cardiodesfibrilación eléctrica. En un ED efectuado inicialmente no se observaron anormalidades significativas, pero otro ED, una TCM y una RMN obtenidos luego del alta, certificaron el hallazgo de miocardio no compactado aislado, descartando coronariopatía. Recibió tratamiento beta bloqueante y antiagregante y se discutió la colocación del cardiodesfibrilador implantable. Se plantea la fisiopatología de la asociación de estas dos infrecuentes y potencialmente letales afecciones.

  12. Identification and evolutionary implication of four novel box H/ACA snoRNAs from Giardia lamblia

    Institute of Scientific and Technical Information of China (English)

    LUO Jun; ZHOU Hui; CHEN Chongjian; LI Yan; CHEN Yueqin; QU Lianghu

    2006-01-01

    From a specialized cDNA library, four novel box H/ACA snoRNAs, named GLsR22,GLsR23, GLsR24 and GLsR25, were identified from the primitive eukaryote, Giardia lamblia. Bioinformatics analyses indicated that all of them can be potentially folded into double hairpins, the typical secondary structures of box H/ACA snoRNAs. GLsR24 and GLsR25 are predicted to guide the site-specific pseudouridylation at U1753 and U2396 on 23S rRNA,respectively, while GLsR22 and GLsR23 belong to the family of "orphan" snoRNAs. All of the four novel snoRNAs are encoded by single copy genes and located in small intergenic regions. Interestingly,compared with the counterparts previously reported in Archaea and other unicellular protozoan, the box H/ACA snoRNAs identified from G. lamblia have unique structural features, implying that snoRNAs evolved from prokaryotes to eukaryotes in different ways.

  13. A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.

    Science.gov (United States)

    Richard, Patricia; Darzacq, Xavier; Bertrand, Edouard; Jády, Beáta E; Verheggen, Céline; Kiss, Tamás

    2003-08-15

    Post-transcriptional synthesis of 2'-O-methylated nucleotides and pseudouridines in Sm spliceosomal small nuclear RNAs takes place in the nucleoplasmic Cajal bodies and it is directed by guide RNAs (scaRNAs) that are structurally and functionally indistinguishable from small nucleolar RNAs (snoRNAs) directing rRNA modification in the nucleolus. The scaRNAs are synthesized in the nucleoplasm and specifically targeted to Cajal bodies. Here, mutational analysis of the human U85 box C/D-H/ACA scaRNA, followed by in situ localization, demonstrates that box H/ACA scaRNAs share a common Cajal body-specific localization signal, the CAB box. Two copies of the evolutionarily conserved CAB consensus (UGAG) are located in the terminal loops of the 5' and 3' hairpins of the box H/ACA domains of mammalian, Drosophila and plant scaRNAs. Upon alteration of the CAB boxes, mutant scaRNAs accumulate in the nucleolus. In turn, authentic snoRNAs can be targeted into Cajal bodies by addition of exogenous CAB box motifs. Our results indicate that scaRNAs represent an ancient group of small nuclear RNAs which are localized to Cajal bodies by an evolutionarily conserved mechanism.

  14. Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.

    Science.gov (United States)

    Vogan, Jacob M; Zhang, Xiaozhu; Youmans, Daniel T; Regalado, Samuel G; Johnson, Joshua Z; Hockemeyer, Dirk; Collins, Kathleen

    2016-08-15

    We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways. To investigate additional rationale for human telomerase assembly as H/ACA RNP, we developed a minimized cellular hTR. Remarkably, with only binding sites for telomerase reverse transcriptase (TERT), minimized hTR assembled biologically active enzyme. TERT overexpression was required for cellular interaction with minimized hTR, indicating that H/ACA RNP assembly enhances endogenous hTR-TERT interaction. Telomere maintenance by minimized telomerase was unaffected by the elimination of the telomerase holoenzyme Cajal body chaperone TCAB1 or the Cajal body scaffold protein Coilin. Surprisingly, wild-type hTR also maintained and elongated telomeres in TCAB1 or Coilin knockout cells, with distinct changes in telomerase action. Overall, we elucidate trafficking requirements for telomerase biogenesis and function and expand mechanisms by which altered telomere maintenance engenders human disease.

  15. Tratamento cirúrgico de um aneurisma primário de veia ilíaca externa

    Directory of Open Access Journals (Sweden)

    Márcio Luís Lucas

    2015-09-01

    Full Text Available ResumoAneurismas primários da veia ilíaca são extremamente raros e podem complicar com trombose, embolia pulmonar ou ruptura. Acredita-se que existam apenas 14 casos descritos na literatura. Neste artigo, descrevemos um caso de um jovem de 25 anos, que apresentava edema e cianose do membro inferior esquerdo. A ecografia vascular revelou uma massa cística em fossa ilíaca esquerda. A angiotomografia confirmou o diagnóstico de um aneurisma da veia ilíaca externa esquerda de 3,8 cm, no maior diâmetro. O paciente foi submetido ao tratamento cirúrgico através da ressecção do aneurisma seguida de venorrafia longitudinal. Teve boa evolução pós-operatória, com um seguimento clínico de 44 meses. Houve uma melhora do edema no membro inferior esquerdo, sem complicações tardias.

  16. Resveratrol food supplements

    DEFF Research Database (Denmark)

    Aschemann-Witzel, Jessica; Grunert, Klaus G

    2015-01-01

    Background: Consumers increasingly choose food supplements in addition to their diet. Research on supplement users finds they are likely to be female, older and well-educated; Furthermore, supplement users are often characterised as being especially health-oriented, an observation which is termed...... the ‘inverse supplement hypothesis’. However, results are dependent on the substance in question. Little is known so far about botanicals in general, and more specifically, little is known about resveratrol. The psychographic variables of food supplement users are yet relatively underexplored. By comparing US...... and Danish respondents, we aimed to identify whether sociodemographic variables, health status, health beliefs and behaviour and interest in food aspects specifically relevant to resveratrol (e.g., naturalness, indulgence, and Mediterranean food) explain favourable attitudes and adoption intentions toward...

  17. Resveratrol food supplements

    DEFF Research Database (Denmark)

    Aschemann-Witzel, Jessica; Grunert, Klaus G

    2015-01-01

    Background: Consumers increasingly choose food supplements in addition to their diet. Research on supplement users finds they are likely to be female, older and well-educated; Furthermore, supplement users are often characterised as being especially health-oriented, an observation which is termed...... and Danish respondents, we aimed to identify whether sociodemographic variables, health status, health beliefs and behaviour and interest in food aspects specifically relevant to resveratrol (e.g., naturalness, indulgence, and Mediterranean food) explain favourable attitudes and adoption intentions toward...... the ‘inverse supplement hypothesis’. However, results are dependent on the substance in question. Little is known so far about botanicals in general, and more specifically, little is known about resveratrol. The psychographic variables of food supplement users are yet relatively underexplored. By comparing US...

  18. Supplemental instruction in chemistry

    Science.gov (United States)

    Lundeberg, Mary A.

    This study was designed to measure some effects of supplemental instruction in chemistry. Supplemental instruction is a peer-led cooperative learning program that encourages students to develop conceptual understanding by articulating both understandings and misconceptions in a think-aloud fashion. Supplemental instruction was offered three hours weekly outside of class and lab time for students in four classes of General Organic and Biological Chemistry. Over a two-year period 108 students volunteered to participate in this program; 45 students did not participate. As measured by final grades in chemistry and responses to a questionnaire, supplemental instruction was effective in increasing students' achievement in chemistry. Further research is needed to determine the in-depth effects of supplemental instruction on students' learning, problem solving, and self-esteem.

  19. Cirurgia cardíaca no idoso Cardiac surgery in elderly patients

    Directory of Open Access Journals (Sweden)

    Danton R. da Rocha LOURES

    2000-03-01

    Full Text Available Com o aumento da expectativa de vida da população brasileira cresce o número de pessoas com idade superior a 70 anos que necessitam de operação cardíaca. CASUÍSTICA E MÉTODOS: Foram avaliados, retrospectivamente, 75 pacientes com idade 3 a 70 anos submetidos a operação cardíaca no HC-UFPR, entre 1995 e 1999, com objetivo de analisarmos os resultados imediatos e tardios. A idade variou de 70 a 88 anos, sendo 34 (46,7% do sexo feminino e 41 (53,3% do masculino. Os principais sintomas foram angina (81,3%, dispnéia (42,6% e síncope (16%. Os pacientes encontravam-se em classe I (57,3%, classe II (17,3%, classe III (18,6% e classe IV (6,6% da NYHA, 61,3% eram hipertensos, 48% tabagistas, 28% diabéticos e 9,3% haviam sido submetidos a operação cardíaca prévia. Foram realizadas 50 (66,6% revascularizações do miocárdio, 9 (12% trocas de valva aórtica, 5 (6,6% operações de aorta, 4 (5,2% trocas valvares + revascularização miocárdica e outros procedimentos (7%. As principais complicações pós-operatórias foram cardiovasculares: arritmias ventriculares (22,6%, arritmias supraventriculares (21,3%, baixo débito cardíaco (16%; infecciosas (16% e pulmonares (9,3%. O tempo médio de permanência na UTI foi de 5 dias. RESULTADOS: A mortalidade hospitalar foi de 13,3% e houve 5 óbitos tardios. Dos sobreviventes, 78,4% compareceram para seguimento ambulatorial. O tempo médio de seguimento foi de 20,7 meses e a sobrevida foi de 92%; um dos óbitos tardios foi de origem cardiovascular. CONCLUSÃO: Apesar de serem pacientes de maior complexidade clínica pela maior incidência de doenças crônicas e acometimento de outros órgãos, os avanços na cirurgia cardíaca e terapia intensiva tornaram possível a intervenção com baixa morbi-mortalidade.BACKGROUND: Because of the increase in the life expectancy of the Brazilian population, elderly patients are being increasingly referred to cardiac surgery. MATERIAL AND METHODS: Seventy

  20. Manifestaciones digestivas y extradigestivas de la enfermedad celíaca.

    Directory of Open Access Journals (Sweden)

    Luis Ortigosa

    2009-11-01

    Full Text Available La enfermedad celíaca (EC es una enteropatía de base autoinmune que se manifiesta en sujetos genéticamente susceptibles, asociada con genes que codifican para las moléculas HLA DQ2 (DQ A1*0501/DQB1*0201 y DQ8 (DQA1*0301/ DQB1*0302. Se caracteriza por una respuesta inmunológica a la ingesta del gluten de trigo y otras prolaminas relacionadas del centeno y la cebada. Las manifestaciones clínicas son diversas, puede haber formas sintomáticas digestivas “clásicas” en niños, y formas extradigestivas en personas de todas las edades. Las manifestaciones atípicas y extradigestivas contribuyen cada vez más a dificultar y demorar el diagnóstico de EC. El uso de marcadores serológicos, especialmente los anticuerpos contra la transglutaminasa tisular, facilita el proceso diagnóstico inicial, que se debe confirmar con una biopsia intestinal para poner de manifiesto unas lesiones histológicas características, con grados variables de atrofia vellositaria, hiperplasia de las criptas e infiltrado linfocitario.

  1. Anemia nos pacientes com insuficiência cardíaca avançada

    Directory of Open Access Journals (Sweden)

    Juliano Cardoso

    2010-10-01

    Full Text Available FUNDAMENTO: Anemia está associada à pior evolução nos pacientes com insuficiência cardíaca (IC. Entretanto, há poucos estudos sobre a anemia nos pacientes com IC avançada. OBJETIVO: Avaliar as características da anemia na IC em fase avançada. MÉTODOS: Foram incluídos 99 pacientes hospitalizados para compensação de IC (CF IV/NYHA, com idade > 18 anos e FEVE 12 g/dl. A anemia foi marcador independente de mau prognóstico na análise multivariada (mortalidade 47% vs 24,6%, p = 0,016, risco relativo 2,54. CONCLUSÃO: Anemia acomete, aproximadamente, 1/3 dos pacientes com IC avançada, e a deficiência de ferro é uma importante etiologia. Pacientes anêmicos são mais idosos e apresentaram função renal mais deteriorada. A melhora da congestão não foi suficiente para melhorar a anemia na maioria dos casos. Nos pacientes com IC avançada, a anemia é marcador independente de mau prognóstico.

  2. SENTIDOS DO SER-AÍ-MULHER-APÓS-CIRURGIA-CARDÍACA À LUZ DE HEIDEGGER

    Directory of Open Access Journals (Sweden)

    Thaís Vasconselos Amorim

    2013-01-01

    Full Text Available Estudio cualitativo con objetivo de presentar el descubrimiento de sentidos del ser-mujer-después-cirugía-cardíaca sostenidos por Heidegger. El escenario fue un hospital de alta complejidad cardiovascular en Minas Gerais, Brasil. La fase de campo se produjo en diciembre de 2011 y enero de 2012, y las entrevistadas fueron llevadas a cabo a partir de la pregunta: ¿Cómo es su día a día después de la cirugía? Las lecturas y escuchas de testimonios posibilitaron análisis y interpretación. La mujer aparece en la publicidad, dominada por impersonal, siendo en la charla, curiosidad y ambigüedad. Revela insuficiencia en temor mediado a través del miedo, horror y terror, en dirección a la de-cadencia. Ante los movimientos existenciales, se puede comprender que como ser-en el-mundo, la mujer se escondió en la disposición para el autocuidado, señalando hueco a ser llenado por el enfermero a través de la promoción de la salud que debe aplicarse en su práctica.

  3. Freqüência cardíaca e risco cardiovascular Heart rate and cardiovascular risk

    Directory of Open Access Journals (Sweden)

    Luiz Antonio Machado César

    2007-10-01

    Full Text Available A freqüência cardíaca (FC também está no centro das determinantes do tempo de vida dos seres vivos animais. Há quase uma constante quando se multiplica a FC pelo número de anos que, em média, vive um animal. O ser humano também tem correlações interessantes de tempo de vida e FC, com estudos epidemiológicos demonstrando maior sobrevivência naqueles com menor FC em repouso, hipertensos, com doença coronariana e na população geral. Neste artigo, revemos estes estudos epidemiológicos e a perspectiva de se, de fato reduzindo a FC, poderemos aumentar o tempo de vida, no caso dos pacientes com doença cardiovascular, de forma independente de outros fatores.Heart rate (HR is known to be one of the factors that in the animal world are related to mortality. When one multiplies resting HR by the average life time, for each animal species, the result is almost the same number, similar to a constant. Apparently, each class of living beings has its "maximal number of heart beats for a life". Herein considerations are made about the relationship between HR and survival in human beings. Some epidemiological studies are reviewed, especially those related to cardiovascular and coronary diseases correlated to deaths and discussions are directed towards the perspective of living longer by lowering the HR.

  4. Withdraw of insurers from ACA markets leaving many southwest patients with few or no choices

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2016-08-01

    Full Text Available No abstract available. Article truncated at 150 words. Thirty-one percent of the nation’s counties are projected to have only one insurer offering health plans on the Affordable Care Act’s (ACA exchanges next year, according to the nonpartisan Kaiser Family Foundation (1. Another 31% are projected to have only be only two. Most of the likely one-insurer counties are predominantly rural (Figure 1. Particularly hard hit is Arizona where most of the rural portions of the state will have only one insurer and Pinal County will have none. Rural Nevada is similarly affected along with Utah, Wyoming, Oklahoma and much of the Southeast US. That would give exchange customers in large areas of the U.S. far less choice than they had this year, when only 7% of counties had one insurer and 29% had two (Figure 2. Many insurers are losing money on the health plans they sell through the exchanges. Insurance giants UnitedHealth, Humana, and Aetna have cited ...

  5. Interrelation of preventive care benefits and shared costs under the Affordable Care Act (ACA).

    Science.gov (United States)

    Dixon, Robert Brent; Hertelendy, Attila J

    2014-08-01

    With the implementation of the Affordable Care Act (ACA), access to insurance and coverage of preventive care services has been expanded. By removing the barrier of shared costs for preventive care, it is expected that an increase in utilization of preventive care services will reduce the cost of chronic diseases. Early detection and treatment is anticipated to be less costly than treatment at full onset of chronic conditions. One concern of early detection of disease is the cost to treat. In reality, the confluence of early detection may result in greater overall expenditures. Even with improved access to preventive care benefits, cost-sharing of other health services remains a major component of insurance plans. In order to treat identified conditions or diseases, cost-sharing comes into play. With the greater adoption of cost-sharing insurance plans, expenditures on the part of enrollee are anticipated to rise. Once the healthcare recipients realize the implication of early identification and resultant treatment costs, enrollment in preventive care may decline. Healthcare legislation and regulation should consider the full spectrum of care and the microeconomic costs associated with preventive treatment. Although the system at large may not realize the immediate impact, behavioral shifts on the part of healthcare consumers may alter healthcare. Rather than the current status quo of treating presenting conditions, preventive treatment is largely anticipated to require more resources and may impact the consumer's financial capacity. This report will explore how these two concepts are co-dependent, and highlight the need for continued reform.

  6. Os efeitos da trimetazidina na variabilidade da frequência cardíaca (VFC em pacientes com insuficiência cardíaca Los efectos de la trimetazidina en la variabilidad de la frecuencia cardíaca (VFC en pacientes con insuficiencia cardíaca The effects of trimetazidine on heart rate variability in patients with heart failure

    Directory of Open Access Journals (Sweden)

    Yilmaz Gunes

    2009-08-01

    Full Text Available FUNDAMENTO: Tem sido demonstrado que diminuições na variabilidade da frequência cardíaca (VFC estão relacionadas com o prognóstico na insuficiência cardíaca (IC. A administração crônica de trimetazidina, além da terapia convencional, tem melhorado a classe funcional e a função ventricular esquerda de pacientes com IC. OBJETIVO: Avaliar os efeitos da trimetazidina na VFC em pacientes com IC de origem isquêmica, recebendo tratamento otimizado. MÉTODOS: Trimetazidina 20 mg 3 vezes/dia foi adicionada à terapia de 30 pacientes com IC tratados com inibidores da enzima conversora de angiotensinogênio ou bloqueadores do receptor da angiotensina, carvedilol, espironolactona, digital e furosemida. A etiologia da IC era doença arterial coronariana em todos os pacientes. Os pacientes foram avaliados através de ecocardiografia e análise da VFC de 24-horas antes e 3 meses depois da adição de trimetazidina. RESULTADOS: A fração de ejeção ventricular esquerda (FEVE média aumentou significantemente após a adição da trimetazidina (33,5±5,1% para 42,5±5,8%, pFUNDAMENTO: Se ha demostrado que disminuciones en la variabilidad de la frecuencia cardíaca (VFC están relacionadas con el pronóstico en la insuficiencia cardíaca (IC. La administración crónica de trimetazidina, además de la terapia convencional, ha mejorado la clase funcional y la función ventricular izquierda de pacientes con IC. OBJETIVO: Evaluar los efectos de la trimetazidina en la VFC en pacientes con IC de origen isquémico, recibiendo tratamiento optimizado. MÉTODOS: Se agregó trimetazidina 20 mg 3 veces/día a la terapia de 30 pacientes con IC tratados con inhibidores de la enzima conversora de angiotensinógeno o bloqueadores del receptor de la angiotensina, carvedilol, espironolactona, digital y furosemida. La etiología de la IC era enfermedad arterial coronaria en todos los pacientes. Los pacientes fueron evaluados mediante ecocardiografía y análisis de

  7. On closed weak supplemented modules

    Institute of Scientific and Technical Information of China (English)

    ZENG Qing-yi; SHI Mei-hua

    2006-01-01

    A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K(c)N<<M. Any direct summand of closed weak supplemented module is also closed weak supplemented.Any nonsingular image of closed weak supplemented module is closed weak supplemented. Nonsingular V-rings in which all nonsingular modules are closed weak supplemented are characterized in Section 4.

  8. Infusión intermitente de inotrópicos en la insuficiencia cardíaca avanzada

    Directory of Open Access Journals (Sweden)

    Héctor O Ventura

    2001-08-01

    Full Text Available Es conveniente seleccionar adecuadamente a los pacientes en los que se administrará terapia con agentes inotrópicos. Se deben descartar potenciales causas reversibles de insuficiencia cardíaca y evaluar factores que puedan precipitar una descompensación. Los pacientes deben estar tratados con dosis máximas de medicamentos convencionales. Los niveles electrolíticos, especialmente potasio y magnesio deben ser controlados periódicamente con el fin de evitar arritmias, manteniendo el potasio por encima de 4mEq/L y el magnesio por encima de 2mEq/L, y evitar que los niveles de digoxina sean mayores de 2ng/dl. Deben seguir adecuadamente las instrucciones médicas y ser dotados de una educación adecuada acerca de su enfermedad junto con sus familiares cercanos. En conclusión, las indicaciones para el uso de agentes inotrópicos en el tratamiento de insuficiencia cardíaca avanzada deberían estar limitadas a: 1. Pacientes que estén en espera de trasplante cardíaco en los que se pueda utilizarlos como un puente hasta que sean trasplantados. 2. Se puede utilizarlos a corto plazo después de cirugía cardíaca para dar un soporte adecuado, hasta que el corazón del paciente comience a funcionar adecuadamente. 3. Como ya hemos discutido extensamente, se pueden utilizar en pacientes con insuficiencia cardíaca inestable y refractaria, como un puente hacia el uso de beta bloqueantes. 4. En pacientes con descompensación aguda. 5. Finalmente se deberían utilizar en pacientes con insuficiencia cardíaca avanzada y que no son candidatos a trasplante cardíaco, en los cuales es indispensable brindarles una calidad de vida mas digna. Idealmente, deben ser los pacientes los que escojan entre un tipo de medicamento que puede mejorar sus síntomas, pero a expensas de una disminución de su sobrevida. Es decir, poder escoger entre calidad versus cantidad.

  9. Resonancia magnética cardíaca: aplicaciones clínicas Cardiac magnetic resonance: clinical applications

    Directory of Open Access Journals (Sweden)

    G. Bastarrika

    2005-04-01

    Full Text Available La enfermedad cardiovascular es la causa más frecuente de mortalidad en los países desarrollados y constituye un grave problema social, económico y sanitario. Aunque existen muy diversas técnicas útiles para diagnosticar las enfermedades cardíacas, con frecuencia es preciso realizar más de una prueba para llegar a un diagnóstico concreto. La resonancia magnética es una técnica inocua, bien tolerada y segura que actualmente se encuentra disponible en la mayoría de los centros hospitalarios. Esta técnica permite estudiar en una única exploración la anatomía del corazón y valorar de forma cualitativa, semicuantitativa y cuantitativa los parámetros de función cardíaca. Es útil para el estudio de las enfermedades valvulares, miocardiopatías y de la enfermedad pericárdica. Aporta información de la anatomía y función cardíaca y vascular en las cardiopatías congénitas complejas. Además, con la administración de contraste intravenoso, permite conocer la viabilidad miocárdica en la cardiopatía isquémica. Por tanto, la resonancia magnética cardíaca se perfila como una de las técnicas más prometedoras para el estudio de la patología cardíaca congénita y adquirida.Cardiovascular disease is the most frequent cause of mortality in the developed countries and represents a serious social, economic and health problem. Although very diverse, useful techniques exist for diagnosing cardiac diseases, it is frequently necessary to ask for more than one test to reach a specific diagnosis. Magnetic resonance is a harmless, well tolerated and safe technique, which is currently available in the majority of hospitals. This technique makes it possible in a single exploration to study the anatomy of the heart and to make a qualitative, semi-quantitative and quantitative assessment of the parameters of cardiac function. It provides information of cardiac and vascular anatomy and function in complex congenital cardiopathies. Besides

  10. Supplements for exotic pets.

    Science.gov (United States)

    Mejia-Fava, Johanna; Colitz, Carmen M H

    2014-09-01

    The use of supplements has become commonplace in an effort to complement traditional therapy and as part of long-term preventive health plans. This article discusses historical and present uses of antioxidants, vitamins, and herbs. By complementing traditional medicine with holistic and alternative nutrition and supplements, the overall health and wellness of exotic pets can be enhanced and balanced. Further research is needed for understanding the strengths and uses of supplements in exotic species. Going back to the animals' origin and roots bring clinicians closer to nature and its healing powers.

  11. Dietary supplements in sport.

    Science.gov (United States)

    Burke, L M; Read, R S

    1993-01-01

    Studies of the dietary practices of athletes report that nutritional supplements are commonly used. Supplementation practices vary between sports and individual athletes; however, there is evidence that at least some athletes use a large number of supplements concurrently, often in doses that are very high in comparison with normal dietary intakes. In exploring supplementation practices we propose a classification system separating the supplements into dietary supplements and nutritional erogogenic aids. The dietary supplement is characterised as a product which can be used to address physiological or nutritional issues arising in sport. It may provide a convenient or practical means of consuming special nutrient requirements for exercise, or it may be used to prevent/reverse nutritional deficiencies that commonly occur among athletes. The basis of the dietary supplement is an understanding of nutritional requirements and physiological effects of exercise. When the supplement is used to successfully meet a physiological/nutritional goal arising in sport it may be demonstrated to improve sports performance. While there is some interest in refining the composition or formulation of some dietary supplements, the real interest belongs to the use or application of the supplement; i.e. educating athletes to understand and achieve their nutritional needs in a specific sports situation. The sports drink (carbohydrate-electrolyte replacement drink) is a well known example of a dietary supplement. Scientific attitudes towards the sports drink have changed over the past 20 years. Initial caution that carbohydrate-electrolyte fluids compromise gastric emptying during exercise has now been shown to be unjustified. Numerous studies have shown that 5 to 10% solutions of glucose, glucose polymers (maltodextrins) and other simple sugars all have suitable gastric emptying characteristics for the delivery of fluid and moderate amounts of carbohydrate substrate. The optimal

  12. Acquisition through Horizontal Gene Transfer of Plasmid pSMA198 by Streptococcus macedonicus ACA-DC 198 Points towards the Dairy Origin of the Species

    Science.gov (United States)

    Papadimitriou, Konstantinos; Anastasiou, Rania; Maistrou, Eleni; Plakas, Thomas; Papandreou, Nikos C.; Hamodrakas, Stavros J.; Ferreira, Stéphanie; Supply, Philip; Renault, Pierre; Pot, Bruno; Tsakalidou, Effie

    2015-01-01

    Background Streptococcus macedonicus is an intriguing streptococcal species whose most frequent source of isolation is fermented foods similarly to Streptococcus thermophilus. However, S. macedonicus is closely related to commensal opportunistic pathogens of the Streptococcus bovis/Streptococcus equinus complex. Methodology/Principal Findings We analyzed the pSMA198 plasmid isolated from the dairy strain Streptococcus macedonicus ACA-DC 198 in order to provide novel clues about the main ecological niche of this bacterium. pSMA198 belongs to the narrow host range pCI305/pWV02 family found primarily in lactococci and to the best of our knowledge it is the first such plasmid to be reported in streptococci. Comparative analysis of the pSMA198 sequence revealed a high degree of similarity with plasmids isolated from Lactococcus lactis strains deriving from milk or its products. Phylogenetic analysis of the pSMA198 Rep showed that the vast majority of closely related proteins derive from lactococcal dairy isolates. Additionally, cloning of the pSMA198 ori in L. lactis revealed a 100% stability of replication over 100 generations. Both pSMA198 and the chromosome of S. macedonicus exhibit a high percentage of potential pseudogenes, indicating that they have co-evolved under the same gene decay processes. We identified chromosomal regions in S. macedonicus that may have originated from pSMA198, also supporting a long co-existence of the two replicons. pSMA198 was also found in divergent biotypes of S. macedonicus and in strains isolated from dispersed geographic locations (e.g. Greece and Switzerland) showing that pSMA198’s acquisition is not a recent event. Conclusions/Significance Here we propose that S. macedonicus acquired plasmid pSMA198 from L. lactis via an ancestral genetic exchange event that took place most probably in milk or dairy products. We provide important evidence that point towards the dairy origin of this species. PMID:25584532

  13. Breastfeeding: Vitamin D Supplementation

    Science.gov (United States)

    ... Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Vitamin D Supplementation Recommend on Facebook Tweet Share Compartir ... not provide infants with an adequate intake of vitamin D. Most breastfed infants are able to synthesize ...

  14. FDA 101: Dietary Supplements

    Science.gov (United States)

    ... dietary supplements to be proven safe to FDA's satisfaction before they are marketed. For most claims made ... the manufacturer or seller to prove to FDA's satisfaction that the claim is accurate or truthful before ...

  15. Dietary Supplement Ingredient Database

    Science.gov (United States)

    ... and US Department of Agriculture Dietary Supplement Ingredient Database Toggle navigation Menu Home About DSID Mission Current ... values can be saved to build a small database or add to an existing database for national, ...

  16. Iron supplements (image)

    Science.gov (United States)

    The mineral iron is an essential nutrient for humans because it is part of blood cells, which carry oxygen to all body cells. There is no conclusive evidence that iron supplements contribute to heart attacks.

  17. Herbal Products and Supplements

    Science.gov (United States)

    ... black cohosh, echinacea, garlic, ginkgo, saw palmetto, and St. John's wort.Are herbal health products and supplements safe?Herbs ... not work the way it should. For example, St. John's wort reduces the amount of certain drugs absorbed by ...

  18. Antioxidant supplements and mortality

    DEFF Research Database (Denmark)

    Bjelakovic, Goran; Nikolova, Dimitrinka; Gluud, Christian

    2014-01-01

    Oxidative damage to cells and tissues is considered involved in the aging process and in the development of chronic diseases in humans, including cancer and cardiovascular diseases, the leading causes of death in high-income countries. This has stimulated interest in the preventive potential of a...... of antioxidant supplements. Today, more than one half of adults in high-income countries ingest antioxidant supplements hoping to improve their health, oppose unhealthy behaviors, and counteract the ravages of aging....

  19. Cardiología intervencionista en arritmias cardíacas: experiencia inicial

    Directory of Open Access Journals (Sweden)

    Oswaldo Gutiérrez

    2000-04-01

    Full Text Available Introducción. La cateterización del corazón en electrofisiología se ha venido utilizando con fines diagnósticos y para establecer el recorrido anatómico de las taquicardias supraventriculares o ventriculares y así detectar zonas críticas suceptibles de ablación. El objetivo de este estudio es brindar una revisión de los casos realizados desde febrero de 1999 hasta la fecha, en el país. Materiales y Métodos. Se incluyeron pacientes que tuvieran las indicaciones usuales para realizar estudio electrofisiológico diagnóstico o procedimientos de ablación por catéter. Se colocaron múltiples catéteres intracardíacos para el registro y estimulación de las cámaras cardíacas así como para la aplicacion de radiofrecuencia. Resultados. Se realizaron 19 estudios (5 diagnósticos y 14 terapéuticos, edades entre 16 y 86 años, 6 hombres y 12 mujeres. Los estudios diagnósticos se realizaron en 3 pacientes con síncope, uno con taquicardia ventricular sostenida y uno con extrasistolia ventricular frecuente. Los procedimientos terapéuticos se realizaron en 3 pacientes con reentrada intranodal (éxito 100%, en 10 con vías accesorias o síndrome de Wolff-Parkinson-White (éxito de 90% y en una se realizó ablación del nódulo Aurículoventricular (100% por crisis de fibrilación auricular de alta respuesta ventricular. Ocurrió recidiva en un caso (seguimiento de 2 a 38 semanas y una complicación en otro (derrame pericárdico. Conclusiones. Estos procedimientos de Cardiología Intervencionista en Arritmias Cardíacas son seguros, aportan información diagnóstica relevante y/o tratamiento curativo con alta tasa de éxito y baja tasa de recurrencia en pacientes con diversos trastornos del ritmo cardíaco.Introduction. Electrophysiological cardiac catheterization have been used for diagnostic purposes and for detection of anatomic circuits of different taquiarrhythmias, suitable for ablation procedures. The objetive of this study is to

  20. Sleeping difficulties reported by patients with heart failure Dificultades para dormir por los pacientes con insuficiencia cardíaca Dificuldades do sono relatadas por pacientes com insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Mariana Alvina dos Santos

    2012-08-01

    Full Text Available The study aimed to describe the reports of heart failure patients on the factors that cause difficulties to sleep and the association of these factors with the quality of sleep. This cross-sectional study involved a non-probabilistic sample of 400 patients (mean age 57.8 years, 64.8% were men, average education of 6.1 years, 82.5% in functional class II or III with heart failure. The main factors associated with sleeping difficulty were: nocturia, interrupted sleep at night and breathing difficulty. Sleeping difficulties in heart failure patients are diverse and there is an association between these difficulties and quality of sleep. Most of these disorders warrant professional nursing interventions.El objetivo del estudio fue describir los informes de los pacientes con insuficiencia cardíaca en los factores que causan dificultades para dormir y la asociación de estos factores con la calidad del sueño. Se trata de un estudio transversal con muestra no probabilística de 400 pacientes (edad media de 57,8 años, 64,8% eran hombres, el promedio de escolaridad de 6,1 años, 82,5% en clase funcional II o III con insuficiencia cardíaca. Los principales factores asociados con dificultad para dormir son: nicturia, interrupción del sueño en la noche y dificultad para respirar. Las dificultades en el sueño de los pacientes con insuficiencia cardíaca son diversas y existe una asociación entre estas dificultades y la calidad del sueño. Estos trastornos, la mayoría son susceptibles de intervención por el personal de enfermería.O estudo teve o objetivo de descrever os relatos de pacientes com insuficiência cardíaca sobre os fatores que causam dificuldades para dormir e a associação desses fatores com a qualidade do sono. Trata-se de estudo transversal, com amostra não probabilística de 400 pacientes (idade média 57,8 anos; 64,8% eram homens; escolaridade média de 6,1 anos; 82,5% em classe funcional II ou III com insuficiência cardíaca

  1. Manejo terapéutico actual de la insuficiencia cardíaca

    Directory of Open Access Journals (Sweden)

    Sarah María Regueira Betancourt

    2014-10-01

    Full Text Available La insuficiencia cardíaca es un síndrome clínico complejo, en el cual ocurren alteraciones anatómicas y funcionales, que dan como resultado un deterioro de la función de bomba del miocardio ventricular (disfunción sistólica o una incapacidad para una correcta relajación y llenado (disfunción diastólica, y es el estadio final de muchas enfermedades cardiovasculares. En el tratamiento de la insuficiencia cardiaca, desde la atención primaria de salud, es tradicional el empleo de diuréticos y digitálicos, que logran alivio de los síntomas, pero con poco impacto sobre la mortalidad y la supervivencia. Se realizó una revisión bibliográfica actualizada, empleando los recursos disponibles en la red Infomed sobre los nuevos enfoques terapéuticos farmacológicos de la insuficiencia cardiaca, tanto por disfunción sistólica, como por disfunción diastólica. En la literatura se evidencia como se han revolucionado las bases del abordaje, tratamiento médico y pronóstico, al complementar el manejo tradicional de esta entidad (diuréticos, digitálicos y potasio e inotrópicos, con la introducción de nuevos grupos farmacológicos, como los inhibidores de la enzima convertidora de la angiotensina II (IECA y los betabloqueadores (BB

  2. Cirurgia cardíaca na gravidez Cardiac surgery during pregnancy

    Directory of Open Access Journals (Sweden)

    Antoninho Sanfins Arnoni

    1986-08-01

    Full Text Available No Instituto Dante Pazzanese de Cardiologia, vem sendo realizado, desde 1975, um trabalho conjunto reunindo obstetras, pediatras, cardiologistas, anestesistas e cirurgiões cardiovasculares, com o intuito de melhorar os resultados da cirurgia cardíaca realizada em pacientes grávidas. Para isto, organizamos um protocolo, que inclui desde o pré-operatório até o nascimento da criança, passando por estudos ecocardiográficos, ultrassonográficos e por monitorização fetal durante a cirurgia. Vinte e seis pacientes foram operadas durante a gravidez, sendo 6 delas em 1985, após o início do estudo. Os resultados, tanto do lado materno como do fetal, são bons, não ocorrendo nenhum óbito materno nesta série e com as crianças nascendo bem e sem malformações e com crescimento e desenvolvimento normais, até o 6º mês de vida extra-uterina.At the Instituto Dante Pazzanese de Cardiologia, a team project has been carried out since 1975, including obstetricians, pediatricians, cardiologists, anesthesiologists and cardiovascular surgeons aim at getting better results of cardiac surgery in pregnant women. For this purpose, the group developed a protocol that goes from the preoperative period to the delivery of the baby, with ecocardiographic and ultrasonic studies and fetal monitoring during the cardiac surgery of the mother. Twenty six patients were submited to cardiac surgery during pregnancy, and six patients after beginning the study, in 1985. The maternal and fetal results were good, without maternal death and the children were born without malformations and having had normal development until the sixth month of life.

  3. Interrelation of Preventive Care Benefits and Shared Costs under the Affordable Care Act (ACA

    Directory of Open Access Journals (Sweden)

    Robert Dixon

    2014-08-01

    Full Text Available With the implementation of the Affordable Care Act (ACA, access to insurance and coverage of preventive care services has been expanded. By removing the barrier of shared costs for preventive care, it is expected that an increase in utilization of preventive care services will reduce the cost of chronic diseases. Early detection and treatment is anticipated to be less costly than treatment at full onset of chronic conditions. One concern of early detection of disease is the cost to treat. In reality, the confluence of early detection may result in greater overall expenditures. Even with improved access to preventive care benefits, cost-sharing of other health services remains a major component of insurance plans. In order to treat identified conditions or diseases, cost-sharing comes into play. With the greater adoption of cost-sharing insurance plans, expenditures on the part of enrollee are anticipated to rise. Once the healthcare recipients realize the implication of early identification and resultant treatment costs, enrollment in preventive care may decline. Healthcare legislation and regulation should consider the full spectrum of care and the microeconomic costs associated with preventive treatment. Although the system at large may not realize the immediate impact, behavioral shifts on the part of healthcare consumers may alter healthcare. Rather than the current status quo of treating presenting conditions, preventive treatment is largely anticipated to require more resources and may impact the consumer’s financial capacity. This report will explore how these two concepts are co-dependent, and highlight the need for continued reform.

  4. Esternotomia parcial mediana em H. Um novo acesso para a cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Loures Danton R.

    1998-01-01

    Full Text Available OBJETIVO: Apresentar a nossa experiência com a toracotomia minimamente invasiva (TMI em pacientes com doença valvar e descrever um novo tipo de toracotomia. MÉTODOS: Vinte e cinco pacientes com doença valvar, como maior problema cardíaco, foram submetidos a operação em um período de 5 meses. A incisão utilizada foi uma TMI em duas formas, uma em T invertido e outra em H. Nesta série, as reoperações constituíram 24%. RESULTADOS: O tamanho da incisão de pele variou de 7,5 a 11,0cm (média = 9,1cm. O tempo de permanência médio na UTI foi de 31h e hospitalar de 4,8 dias. Em todos os pacientes a cirurgia pôde ser realizada apropriadamente através deste acesso, sendo que em apenas um, foi necessária esternotomia total. CONCLUSÃO: A TMI apresenta algumas vantagens, como melhor resultado estético, menos dor e maior estabilidade torácica. Estes fatores possibilitam uma extubação precoce, diminuindo o tempo de internação hospitalar. A esternotomia em H apresenta como grande benefício a exposição da parte mais central do tórax, permitindo um melhor acesso a todas as valvas cardíacas. Esta técnica não apresentou complicações nas reoperações, o que nos faz acreditar que seja tão segura quanto a esternotomia total.

  5. Active components in food supplements

    NARCIS (Netherlands)

    Siemelink M; Jansen EHJM; Piersma AH; Opperhuizen A; LEO

    2000-01-01

    The growing food supplement market, where supplements are both more diverse and more easily available (e.g. through Internet) formed the backdrop to the inventory of the active components in food supplements. The safety of an increased intake of food components via supplements was also at issue her

  6. Relação entre imagem adrenérgica cardíaca e teste ergométrico na insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Leandro Rocha Messias

    2011-05-01

    Full Text Available FUNDAMENTO: Na insuficiência cardíaca, o teste ergométrico (TE avalia capacidade funcional, um determinante de prognóstico. A cintilografia com I¹²³ MIBG mostra a ativação simpática cardíaca. OBJETIVO: Avaliar a associação entre as variáveis do TE e as alterações da cintilografia com I¹²³ MIBG. MÉTODOS: Foram submetidos 23 pacientes (FEVE 27%. Esses pacientes realizaram TE, onde foram analisadas: pressão arterial sistólica no pico do esforço (PASP, frequência cardíaca no pico do esforço (FCP, variação da pressão arterial sistólica intraesforço (Δ PAS, reserva cronotrópica e capacidade funcional em METs. Utilizaram-se para a análise estatística, o teste t de Student ou o teste U de Mann-Whitney, o coeficiente de Spearman e o coeficiente de regressão linear. RESULTADOS: A PASP (G1: 181,00 ± 28,01; G2: 153,27 ± 27,71, p = 0,027, a Δ PAS [G1: 64 (47,5-80,5; G2: 36 (25-47 mmHg, p = 0,015], a FCP (G1: 136,91 ± 19,66; G2: 118,45 ± 13,98 bpm, p = 0,018, a reserva cronotrópica (G1: 70,42 ± 17,94; G2: 49,47 ± 14,89%, p = 0,006 e a capacidade funcional [G1: 8,37 (6,47-10,27; G2: 4,42 (2,46-6,38 METs, p = 0,003] foram menores no G2. Houve correlação negativa entre taxa de Washout com PASP (r = -0,505, p = 0,014, Δ PAS (r = -0,493, p = 0,017 e capacidade funcional (r = -0,646, p = 0,001. Após regressão linear, PASP (r = -0,422, p = 0,016 e capacidade funcional (r = -0,804, p = 0,004 foram associadas com taxa de Washout. CONCLUSÃO: Em pacientes com insuficiência cardíaca, PASP e capacidade funcional foram as varáveis mais associadas com a taxa de Washout.

  7. Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade.

    Science.gov (United States)

    Bahn, Yong-Sun; Hicks, Julie K; Giles, Steven S; Cox, Gary M; Heitman, Joseph

    2004-12-01

    The evolutionarily conserved cyclic AMP (cAMP) signaling pathway controls cell functions in response to environmental cues in organisms as diverse as yeast and mammals. In the basidiomycetous human pathogenic fungus Cryptococcus neoformans, the cAMP pathway governs virulence and morphological differentiation. Here we identified and characterized adenylyl cyclase-associated protein, Aca1, which functions in parallel with the Galpha subunit Gpa1 to control the adenylyl cyclase (Cac1). Aca1 interacted with the C terminus of Cac1 in the yeast two-hybrid system. By molecular and genetic approaches, Aca1 was shown to play a critical role in mating by regulating cell fusion and filamentous growth in a cAMP-dependent manner. Aca1 also regulates melanin and capsule production via the Cac1-cAMP-protein kinase A pathway. Genetic epistasis studies support models in which Aca1 and Gpa1 are necessary and sufficient components that cooperate to activate adenylyl cyclase. Taken together, these studies further define the cAMP signaling cascade controlling virulence of this ubiquitous human fungal pathogen.

  8. Relación entre los índices de funcionalidad cardíaca y cognitiva en personas mayores institucionalizadas

    Directory of Open Access Journals (Sweden)

    Carmen Requena Hernández

    2014-12-01

    Full Text Available Los datos más recientes sugieren que la disfunción cardíaca, cuantificada por el gasto cardíaco, está relacionada con el funcionamiento cognitivo. Objetivo: determinar si el funcionamiento cardíaco actúa como predictor de la función cognitiva en personas institucionalizadas con índice cardíaco normal. Método: estudio observacional con una muestra de 30 sujetos mayores de 80 años, con historial médico clínico sin cardiopatías. Resultados: el análisis de regresión múltiple confirma que las variables cardíacas de riesgo cardiovascular e insuficiencia cardíaca son predictoras del nivel de funcionamiento cognitivo y acumulan un 95,1% de la varianza. Sin embargo, destaca la notable falta de correspondencia entre las medidas clínicas cardíacas y cognitivas con la medida biológica de índice cardíaco. Conclusión: aunque los datos observacionales no pueden establecer causalidad, nuestros resultados muestran que la función cardíaca con índice cardíaco normal se asocia con deterior cognitivo

  9. Avaliação do sensor de contratilidade cardíaca em sistema DDDR: estudo multicêntrico

    Directory of Open Access Journals (Sweden)

    ANDRADE José Carlos S.

    1998-01-01

    Full Text Available Introdução: O tratamento de distúrbios na condução atrioventricular associados a doenças do nó sinusal com o emprego de marcapassos DDDR tem incentivado a procura de um sensor ideal. Objetivo: Avaliar a resposta de freqüência do marcapasso com sensor de contratilidade em situações de esforço físico e mental, tanto em laboratório como em atividades diárias de pacientes com bradicardia e insuficiência cronotrópica. Casuística e Métodos: Do estudo multicêntrico brasileiro "Projeto Inos DR _ Brasil", que emprega um sistema de estimulação DDDR cujo indicador é o estado contrátil do miocárdio, foram selecionados 38 pacientes com insuficiência cronotrópica, sendo 21 do sexo masculino e 17 do sexo feminino, com idades variando de 13 a 83 anos (média de 57 anos. O marcapasso utiliza um parâmetro do próprio controle cardiovascular (contratilidade cardíaca obtida pela medida da impedância cardíaca unipolar para a adaptação da freqüência cardíaca, num sistema de malha fechada que, teoricamente, possibilita um ajuste a todas as necessidades fisiológicas. A calibração e programação do sistema só foi realizada 30 dias após o implante (tempo de maturação da irterface coração-eletrodo, realizando-se, então, teste de estresse mental (matemático e teste ergométrico (em esteira, monitorados com histograma de freqüência e com curvas de consumo de oxigênio. Resultados: A média de limiares agudos de estimulação foi de 0,82 Volts e 0,55 Volts, e a média de limiares de sensibilidade foi de 2,37 mV e 10,61 mV, respectivamente, para átrios e ventrículos. A média de limiares crônicos de estimulação foi de 1,44 Volts e 1,18 Volts, e a média de limiares de sensibilidade foi de 2,81 mV e 6,3 mV, respectivamente para átrios e ventrículos. A freqüência cardíaca variou de 5% a 128% nas atividades físicas e de 5% a 80% nas atividades mentais, com elevação logo no início das atividades, permitindo uma curva

  10. Realidad de la cirugía cardíaca en la República Argentina. Registro CONAREC XVI

    Directory of Open Access Journals (Sweden)

    Diego M. Lowenstein Haber

    2010-01-01

    Full Text Available RESUMENIntroducciónLos dos grandes registros multicéntricos de cirugía cardíaca realizados en la Argentina,CONAREC y ESMUCICA, datan de más de 10 años. Considerando los avances médicosy quirúrgicos de la última década, surgió la necesidad de realizar un nuevo registronacional, prospectivo y multicéntrico para conocer las características, la evolución, lascomplicaciones y los predictores de mortalidad de los pacientes sometidos a cirugía cardíaca.ObjetivosConocer el perfil epidemiológico, la modalidad quirúrgica y la evolución posoperatoria de lospacientes sometidos a cirugía cardíaca en la Argentina.Material y métodosRegistro prospectivo, consecutivo y multicéntrico realizado en 49 centros cardioquirúrgicosde la República Argentina por residentes de cardiología. Se analizaron las características yla evolución de 2.553 pacientes sometidos a cirugía cardíaca entre septiembre de 2007 yoctubre de 2008: 1.465 (57,4% a cirugía coronaria, 359 (14,1% a reemplazo valvular aórtico,169 (6,6% a cirugía valvular mitral, 312 (12,2% a cirugía combinada coronariovalvular y248 (9,7% a otros procedimientos.ResultadosHubo predominio de hombres (74,9%; la edad promedio fue de 63 ± 11 años. La prevalenciade diabetes fue del 24,9%, la de hipertensión del 76,3% y la de insuficiencia cardíaca del17%. La disfunción ventricular moderada a grave prequirúrgica fue del 23,8% y el 19,8% delas cirugías fueron no programadas.En las cirugías coronarias, el 41,9% de ellas se realizaron sin circulación extracorpórea y seempleó puente mamario en el 89%.El 81,7% de las cirugías mitrales se indicaron por insuficiencia y el 62,6% de las aórticas,por estenosis. En estas cirugías se emplearon válvulas mecánicas en el 58% de los casos.La mediana de internación fue de 6 días. Se presentaron complicaciones mayores en el31,7% (del 25% en coronarios al 49,36% en combinados y la mortalidad global fue del 7,7%(del 4,3% en coronarios al 13

  11. Cirugía cardíaca estratificada por EuroSCORE: Supervivencia a largo plazo

    Directory of Open Access Journals (Sweden)

    Raúl A. Borracci

    2013-10-01

    Full Text Available El objetivo fue explorar la utilidad del EuroSCORE logístico para estratificar las curvas de supervivencia alejada en una muestra de pacientes sometidos a cirugía cardíaca. Se analizaron los resultados a 8 años de 390 pacientes sometidos a cirugía cardíaca entre 2003-2004, de acuerdo al puntaje inicial del EuroSCORE logístico, divididos en tres grupos de riesgo: < 5%, 5-14.9% y ≥15%. La supervivencia por Kaplan-Meier a 8 años de la cirugía coronaria dividida por el EuroSCORE fue 83.5% para un riesgo inicial < 5%, 65.2% para un riesgo inicial entre 5 y 14.9% y 40.0% para un riesgo inicial ≥15% (p = 0.000; mientras que de la cirugía valvular o combinada fue 86.1%, 60.0% y 18.2% respectivamente (p = 0.0000. Para el total de pacientes, el área ROC fue 0.759 (p = 0.000, para un EuroSCORE <5% fue 0.689 (p = 0.002, entre 5 y 14.9% fue 0.544 (p = 0.499 y para ≥15% fue 0.725 (p = 0.067. En conclusión, el EuroSCORE logístico permitió estratificar adecuadamente las curvas de supervivencia alejada en una muestra de pacientes sometidos a cirugía cardíaca, tanto en la cirugía coronaria como en la valvular o combinada. La estratificación de los resultados a largo plazo separados por riesgo constituye una forma razonable de presentar el pronóstico.

  12. El ACA e YPF entre las administraciones conservadoras y el peronismo: La red nacional de estaciones de servicios

    Directory of Open Access Journals (Sweden)

    Melina Piglia

    Full Text Available El trabajo aborda el análisis del vínculo entre el Automóvil Club Argentino (ACA e YPF en sus primeras década. El objetivo es pensar, simultáneamente dos dimensiones: por un lado, la de la construcción de la primera red nacional de estaciones de servicio, complemento de la nueva red de caminos y presencia crucial en algunas regiones desoladas; por el otro, la de la compleja relación entre una institución civil y el Estado, que estuvo por detrás de esa construcción. La expansión de la esfera estatal en los años treinta adoptó frecuentemente la forma de una articulación de los aparatos del Estado con las asociaciones representantes de intereses particulares. En ese marco, en 1936 el ACA firmó con YPF un provechoso convenio de exclusividad para la venta de los productos fiscales, gracias al cual construyó más de 90 estaciones de servicio entre 1937 y 1955. Con el ascenso del peronismo, el Plan ACA-YPF continuó desarrollándose. Sin embargo, en esta nueva etapa el club estuvo sometido a una mayor supervisión estatal y vio recortada su autonomía en el manejo de las estaciones de servicio, lo que trajo como resultado el endeudamiento de la institución a niveles cada vez más críticos.

  13. Análisis comportamental aplicado (ACA) y trastornos generalizados del desarrollo (TGD): su evaluación en Argentina

    OpenAIRE

    María de los Angeles Matos; Alba Elisabeth Mustaca

    2005-01-01

    Se presentan los resultados obtenidos con la intervención basada en Análisis Comportamental Aplicado (ACA) o manejo de contingencias, en 9 niños (8 varones y 1 mujer) de 2 a 5 años con Trastornos Generalizados del Desarrollo (TGD). Este tratamiento basado en métodos desarrollados por Lovaas y colaboradores (1981) fue implementado en una institución argentina especializada. Se evaluaron las siguientes áreas: comprensión del lenguaje, funciones del comportamiento, nivel ...

  14. Estimación del número de cirugías cardíacas en la Argentina

    Directory of Open Access Journals (Sweden)

    Griselda T. Martínez

    2007-01-01

    Full Text Available Aunque existen bases de datos de cirugía cardíaca en diferentes países, en la Argentina se carece de registros nacionales que sirvan para conocer y planificar esta práctica en el contexto de la actividad sanitaria del país. Con el objetivo de comunicar una estimación anual del número de cirugías cardíacas efectuadas en adultos en el país, se realizó un registro nacional retrospectivo de todas las cirugías cardíacas en adultos entre julio de 2005 y junio de 2006 en todo el territorio argentino, con los porcentajes de cada región y la tasa de uso. El grado de inequidad en la distribución de las cirugías se evaluó con una curva de Lorenz. A fin de justificar las variaciones regionales, las tasas de uso se correlacionaron con el porcentaje de la población no cubierta por un plan médico y con el porcentaje de población con “necesidades básicas insatisfechas”. Se realizaron 10.476 cirugías en 172 centros de todo el país, lo cual indica una tasa de uso de una cirugía cada 2.673 habitantes por año (374 cirugías por millón, por debajo de los estándares mundiales (500 a 1.000 por millón. Este registro anual retrospectivo permitió calcular por primera vez el número de cirugías cardíacas de todo el país, su distribución regional y la tasa de uso. Los hallazgos en la curva de Lorenz y el coeficiente de Gini permitirían sugerir una distribución inadecuada del acceso de toda la población a este tipo de práctica. Estos datos constituyen una primera aproximación para la implementación de un registro nacional prospectivo más amplio y permanente.

  15. El sildenafil mejora la capacidad de ejercicio en pacientes con insuficiencia cardíaca crónica

    Directory of Open Access Journals (Sweden)

    Clemente H. Magallanes

    2010-01-01

    Full Text Available AntecedentesLos agentes inhibidores de la fosfodiesterasa 5, como el sildenafil, son vasodilatadores moderados ampliamente utilizados para el tratamiento de la disfunción eréctil. En la actualidad, la evidencia disponible establece su potencial aplicación en otras patologías, como la hipertensión pulmonar, la disfunción endotelial y la insuficiencia cardíaca crónica. ObjetivoEl presente estudio fue diseñado para comprobar si la administración de sildenafil en pacientes con insuficiencia cardíaca crónica en clase funcional II-III mejora la capacidad de ejercicio en comparación con placebo.Material y métodosSe seleccionaron en forma aleatoria 70 pacientes portadores de insuficiencia cardíaca crónica de cualquier etiología, excepto valvulares, todos con tratamiento óptimo. Para su inclusión en el estudio, los pacientes debían tener un diámetro diastólico ventricular izquierdo > 55 mm, una fracción de eyección 90 mm Hg. Se excluyeron los que se encontraban anémicos, aquellos con indicación de cirugía por cualquiercausa o los que por diversos motivos no pudieran realizar una caminata de seis minutos. Luego de una caminata de seis minutos fueron aleatorizados para recibir 50 mg de sildenafil o placebo, conformándose dos grupos, placebo y sildenafil, ambos con 35 participantes. Luego de 1 hora de la ingestión de las drogas se realizó una nueva caminata de seis minutos. Antes y después de cada caminata se controlaron las siguientes variables: presión arterial sistólica, diastólica y frecuencia cardíaca; se registraron también los metros caminados en cada prueba.ResultadosCaracterísticas generales, grupo placebo versus grupo sildenafil: hombres: 74% vs 88%, etiología isquémico-necrótica: 71% vs 77%, clase funcional II: 37% vs 34%, clase funcional III: 63% vs 66%, edad: 68 ± 10 vs 68 ± 12 años, fracción de eyección: 26,5% ± 7,8% vs 26,5% ± 6,5%, diámetro diastólico ventricular izquierdo: 65 ± 6 vs 66 ± 9

  16. Deterioro cognitivo, cirugía cardíaca y circulación extracorpórea

    OpenAIRE

    Pérez Belmonte, Luis Miguel

    2014-01-01

    El deterioro cognitivo postoperatorio junto con otras alteraciones neurológicas suponen unas de las complicaciones más frecuentes tras la cirugía cardíaca. Para evaluar los efectos cognitivos de esta cirugía, hemos realizado este estudio donde se evalúan diferentes dominios neurocognitivos mediante una batería de test incluyendo la evaluación preoperatoria y un seguimiento hasta un año posterior, convertiéndose en el primer estudio de estas características en población española....

  17. Sintomas gastrintestinais discretos: um novo olhar sobre formas de apresentação clínica da doença celíaca

    OpenAIRE

    Teresa Cavalcante de Albuquerque, Letícia

    2009-01-01

    Racional: A apresentação clínica da doença celíaca é variável. Devido ao conhecimento atual de que as lesões da mucosa intestinal podem ocorrer em placa ou mesmo não acometer toda a extensão da mucosa, é possível que pacientes com sintomas gastrintestinais discretos possam ser portadores de doença celíaca e mereçam investigação diagnóstica para essa doença. Objetivo: Determinar as freqüências de sorologia e histologia intestinal positivas para doença celíaca em crianças e adole...

  18. Evolução e prognóstico materno-fetal da cirurgia cardíaca durante a gravidez

    OpenAIRE

    Walkiria Samuel Ávila; Ana Maria Milani Gouveia; Pablo Pomerantzeff; Maria Rita Lemos Bortolotto; Max Grinberg; Noedir Stolf; Marcelo Zugaib

    2009-01-01

    FUNDAMENTO: A cirurgia cardíaca favorece o prognóstico materno em casos refratários à terapêutica clínica, contudo associa-se a riscos ao concepto quando realizada durante a gravidez. OBJETIVO: Analisar a evolução e o prognóstico materno-fetal de gestantes submetidas à cirurgia cardíaca no ciclo gravídico-puerperal. MÉTODOS: Estudou-se a evolução de 41 gestações de mulheres que tiveram indicação de cirurgia cardíaca no ciclo gravídico puerperal. A cardiotocografia fetal foi mantida durante o ...

  19. Fibrilación auricular en el postoperatorio de cirugía cardíaca: Prevalencia y tiempo de internación

    OpenAIRE

    Alejandro E. Contreras; Adolfo Ferrero Guadagnoli; Eduardo J. Brenna; Pablo Pogonza; Luis A. Coppa; Guillermo G. Paladini; Salomone, Oscar A.

    2010-01-01

    La fibrilación auricular es el trastorno del ritmo más frecuente luego de la cirugía cardíaca. En estudios previos se ha asociado a prolongación de la internación, aumento en los costos e incremento en la mortalidad. El objetivo de este estudio fue conocer la prevalencia de fibrilación auricular en el postoperatorio de cirugía cardíaca y determinar el efecto en el tiempo de estadía hospitalaria. Se analizaron retrospectivamente las historias clínicas de pacientes sometidos a cirugía cardíaca ...

  20. Perfil clínico y funcional de los pacientes con insuficiencia cardíaca sistólica y disfunción renal

    OpenAIRE

    ADRIANA ACOSTA; MÁXIMO MIGLIORI; NORA VAINSTEIN; JAVIER C. MARINO; RAMIRO GUGLIELMONE; MARCELO S. TRIVI; MÓNICA SULTÁN; FERNANDO BRITES; JORGE M. THIERER

    2009-01-01

    RESUMENIntroducciónLa disfunción renal está fuertemente asociada con la insuficiencia cardíaca crónica. Es unacomplicación habitual y progresiva de esta condición, con una evolución clínica que fluctúacon la clase funcional y el tratamiento farmacológico.ObjetivosDefinir la prevalencia y el perfil clínico y funcional de pacientes con disfunción renal en elcontexto de insuficiencia cardíaca con baja fracción de eyección.Material y métodosEn 132 pacientes con insuficiencia cardíaca y fracción d...

  1. 92. Desarrollo y resultados iniciales de un programa de cirugía cardíaca robótica. ¿Qué hemos aprendido?

    OpenAIRE

    J.M. Borrego Domínguez; A. Hernández Fernández; E. Gutiérrez Carretero; A. Adsuar; M. Bertomeu Cornejo; I. Bibiloni Lage; E. Ruiz Solano; J.C. Luis Navarro; M.J.a Eslava; N. Romero Rodríguez

    2010-01-01

    A principios de 2008 nuestro servicio se incorporó a un estudio cuyo objetivo era la evaluación de efectividad y seguridad de la cirugía cardíaca robótica (Da Vinci) e inició el diseño e implementación de un programa de cirugía cardíaca asistida por Da Vinci en nuestro Hospital. Metodología y resultados: Se presentan 11 procedimientos de cirugía cardíaca asistida por Da Vinci realizados en nuestro hospital siguiendo un programa de entrenamiento previamente diseñado: cinco casos de sustituc...

  2. Supplements and sports.

    Science.gov (United States)

    Jenkinson, David M; Harbert, Allison J

    2008-11-01

    Use of performance-enhancing supplements occurs at all levels of sports, from professional athletes to junior high school students. Although some supplements do enhance athletic performance, many have no proven benefits and have serious adverse effects. Anabolic steroids and ephedrine have life-threatening adverse effects and are prohibited by the International Olympic Committee and the National Collegiate Athletic Association for use in competition. Blood transfusions, androstenedione, and dehydroepiandrosterone are also prohibited in competition. Caffeine, creatine, and sodium bicarbonate have been shown to enhance performance in certain contexts and have few adverse effects. No performance benefit has been shown with amino acids, beta-hydroxy-beta-methylbutyrate, chromium, human growth hormone, and iron. Carbohydrate-electrolyte beverages have no serious adverse effects and can aid performance when used for fluid replacement. Given the widespread use of performance-enhancing supplements, physicians should be prepared to counsel athletes of all ages about their effectiveness, safety, and legality.

  3. Ergogenic Aids and Supplements.

    Science.gov (United States)

    Porrini, Marisa; Del Boʼ, Cristian

    2016-01-01

    Great interest is currently shown for the contribution of nutrition to optimize training and athletic performance, and a considerable debate exists about the potential ergogenic value of several dietary supplements. However, most of the products used by athletes do not provide sufficient scientific evidence regarding their efficacy in enhancing physical performance as well as their specificity of action and safety. For this reason, sport nutrition professionals need skills in evaluating the scientific value of papers and advertisements on ergogenic aids and supplements in order to support athletes in their choice. In the present chapter, the efficacy of some of the most popular supplements used by athletes and sport practitioners will be discussed. Particular attention will be devoted to amino acids and derivatives, caffeine and caffeinated energy drinks, and some antioxidants.

  4. Variabilidad de la frecuencia cardíaca en individuos sanos costarricenses

    Directory of Open Access Journals (Sweden)

    Oswaldo Gutiérrez Sotelo

    2000-04-01

    Full Text Available Introducción. El análisis de la variabilidad de la frecuencia cardíaca (VFC, refleja la influencia autonómica sobre el corazón pudiendo ser predictivo de mortalidad. Consiste en el análisis de las variaciones de los intervalos RR. Este estudio analizó la VFC en individuos sanos costarricenses. Materiales y Métodos. Fueron elegidos adultos asintomáticos. En la adquisición de datos se utilizó una derivación electrocardiográfica estándar y se calcularon variables tanto en Dominio de Tiempo como en Dominio de Frecuencia. Se compararon los resultados desde registros de 5 minutos y de 10 minutos y se compararon diferentes grupos etáreos dividiéndose a la población en grupos: 18 a 29 años, 30 a 39 y 40 y también entre Introduction. Heart rate variability analysis evaluate the autonomic influence over the heart and therefore, is a predictive tool of mortality. It consists in the analysis of the variations in RR intervals. This study assessed heart rate variability in healthy costarrican people. Materials and Methods. We included adult healthy volunteers. For data adquisition we used a single electrocardiographic lead and calculate time and frequency domain variables. We compared results between 5 minutes versus 10 minutes samples and between age groups: 18 to 29 years old, versus 30 to 39 versus 40 or < 25 years old versus 25. Results. We studied 48 subjects, 25 women and 23 men (range 18 y 53. We do not obtained differences between time of data adquisition samples but find differences between 18-29 vs 40 and <25 vs 25 age groups in NN50 (231.432 vs 34.500, p = 0.004 in the fisrt group, 237.250 vs 53.250, p<0.001, the second, %NN50 (30.732 vs 5.2, p=0.003 and 31.444 vs 9.742, p=0.001 respectively, LF (457.338 vs 173.393, p=0.045 and 466.816 vs 259.361, p=0.042 respectively and HF (750.667 vs 239.865, p=0.068 and 766.834 vs 248.436, p=0.010 respectively. Conclusions. This study support reference values for comparision or to individual

  5. Diseño y desarrollo de un probador de fatiga dinámica para soportes de bioprótesis valvulares cardíacas

    Directory of Open Access Journals (Sweden)

    Sergio Tamayo

    2001-04-01

    Full Text Available Las bioprótesis valvulares cardíacas implantadas están expuestas a esfuerzos físicos causados por las contracciones cardíacas y la presión generada por la sangre. Los componentes de la bioprótesis, incluyendo el anillo soporte, pueden variar las propiedades mecánicas
    a largo plazo, por los esfuerzos que soporta crónicamente, dando como resultado la fatiga del material. En estas condiciones el elemento puede fallar aun cuando el máximo esfuerzo aplicado sea menor que la resistencia del material determinado en pruebas estáticas.

  6. Prevalência de doença celíaca em crianças e adolescentes com miocardite e cardiomiopatia dilatada

    Directory of Open Access Journals (Sweden)

    Thaysa Maria Gama Albuquerque Leão de Menezes

    2012-10-01

    Full Text Available OBJETIVO: Determinar a prevalência de doença celíaca em pacientes portadores de cardiomiopatia dilatada e miocardite. MÉTODOS: Foram avaliados 56 pacientes, com idade entre 1 e 18 anos, portadores de cardiomiopatia dilatada ou miocardite, acompanhados no Instituto Materno Infantil Professor Fernando Figueira. Foram excluídos pacientes com diagnóstico prévio de doença celíaca. A classe funcional da insuficiência cardíaca foi determinada segundo os critérios da American Heart Association, como classe funcional I, II, III e IV. O diagnóstico de miocardite foi relatado em prontuário, e o de cardiomiopatia dilatada, pelo ecocardiograma, a partir da presença de disfunção sistólica de um ou ambos os ventrículos, com fração de ejeção menor que 55% e dilatação ventricular, com diâmetro diastólico final ventricular esquerdo maior que 112%. Nos pacientes incluídos no estudo, foi aplicado um formulário com informações sobre sintomatologia gastrointestinal e cardiológica; em seguida, dosadas sorologias para anticorpos antitransglutaminase tecidual humana e antiendomísio. Aqueles com sorologia positiva foram encaminhados à biópsia intestinal para avaliação histológica para doença celíaca, segundo os critérios de Marsh. RESULTADOS: Uma das 56 crianças apresentou sorologia antitransglutaminase positiva (1,8%, porém anticorpo antiendomísio negativo. A histologia intestinal demonstrou atrofia total das vilosidades. Cerca de 30% dos pacientes apresentaram insuficiência cardíaca. Sinais e sintomas gastrointestinais foram frequentes nos pacientes, em especial dor abdominal (70%, 39/56. CONCLUSÃO: A frequência de doença celíaca em pacientes com cardiomiopatia dilatada e miocardite foi de 1,8%. É importante investigar doença celíaca nos pacientes com essas doenças cardíacas para evitar evolução das doenças e deterioração clínica do paciente.

  7. Alteraciones fisiopatólogicas secundarias a circulación extracorpórea en cirugía cardíaca

    OpenAIRE

    A. Gabriela Valenzuela-Flores; Adriana Abigail Valenzuela-Flores; J. Alberto Ortega-Ramírez; Martín Penagos-Paniagua; José Pascual Pérez-Campos

    2005-01-01

    La circulación extracorpórea (derivación cardiopulmonar) es uno de los métodos utilizados en la cirugía convencional de revascularización coronaria. Su uso puede asociarse con el desarrollo de eventos adversos que, si bien no comunes (2%), pueden aumentar la mortalidad en 70 %. La cirugía cardíaca y la circulación extracorpórea activan la respuesta inflamatoria caracterizada por alteraciones cardiovasculares y pulmonares. La respuesta inflamatoria se inicia durante la cirugía cardíaca por div...

  8. Ressonância magnética cardíaca e seus planos anatômicos: como eu faço?

    Directory of Open Access Journals (Sweden)

    Marcelo Souto Nacif

    2010-12-01

    Full Text Available Devido à crescente utilização do método de ressonância magnética cardíaca (RMC e sua frequente implantação em novos serviços, apresentaremos neste trabalho, em um formato passo a passo, as técnicas de aquisição, necessárias para uma completa abordagem cardíaca, dos principais planos anatômicos do coração utilizados pela RMC.

  9. Prevalência de anemia e insuficiência renal em portadores de insuficiência cardíaca não-hospitalizados

    OpenAIRE

    Reis, Francisco José Farias Borges dos; Fernandes, André Maurício Souza; Bitencourt, Almir Galvão Vieira; Neves, Flávia Branco Cerqueira Serra; Kuwano,André Yoichi; França,Victor Hugo Pinheiro; de Macedo, Cristiano Ricardo Bastos; Cruz,Cristiano Gonçalves da; Sahade, Viviane; Aras Júnior, Roque

    2009-01-01

    FUNDAMENTOS: Insuficiência cardíaca (IC) é uma doença comum com alta taxa de mortalidade. Anemia e insuficiência renal (IR) são frequentemente encontradas em portadores de IC associadas com maior gravidade da doença cardíaca e pior prognóstico. OBJETIVO: Avaliar a prevalência de anemia e insuficiência renal, bem como a associação entre esses dois quadros, em portadores de IC não hospitalizados. MÉTODOS: Foram observados pacientes acompanhandos na clínica de IC de um hospital universitário de ...

  10. Fase de convalecencia en la rehabilitación cardíaca. Protocolo de actuación

    Directory of Open Access Journals (Sweden)

    Susana Hernández García

    2015-03-01

    Full Text Available La fase de convalecencia de la rehabilitación cardíaca tiene como propósito fundamental mejorar la capacidad funcional y fomentar un cambio del estilo de vida a través de todos los aspectos que integra la prevención secundaria fundamentalmente, en la incorporación a un programa de entrenamiento físico y en el control de los factores de riesgo cardiovascular, lo que favorece la reincorporación social y laboral de los enfermos. Con el objetivo de actualizar el protocolo de actuación de esta fase en nuestra institución se establecieron diferentes ejercicios con sus dosificaciones y recomendaciones para la rehabilitación de diferentes poblaciones, así como controles de la sesión de entrenamiento físico a tener en cuenta. Este protocolo permitirá aunar estrategias para mejorar la intervención fisioterapéutica en la fase de convalecencia del Programa Nacional de Rehabilitación Cardíaca en Cuba.

  11. Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA.

    Science.gov (United States)

    Deng, Li; Wang, Guohua; Yu, Suihuai

    2016-01-01

    In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm) were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method.

  12. The Dictyostelium discoideum acaA gene is transcribed from alternative promoters during aggregation and multicellular development.

    Directory of Open Access Journals (Sweden)

    Maria Galardi-Castilla

    Full Text Available BACKGROUND: Extracellular cAMP is a key extracellular signaling molecule that regulates aggregation, cell differentiation and morphogenesis during multi-cellular development of the social amoeba Dictyostelium discoideum. This molecule is produced by three different adenylyl cyclases, encoded by the genes acaA, acrA and acgA, expressed at different stages of development and in different structures. METHODOLOGY/PRINCIPAL FINDINGS: This article describes the characterization of the promoter region of the acaA gene, showing that it is transcribed from three different alternative promoters. The distal promoter, promoter 1, is active during the aggregation process while the more proximal promoters are active in tip-organiser and posterior regions of the structures. A DNA fragment containing the three promoters drove expression to these same regions and similar results were obtained by in situ hybridization. Analyses of mRNA expression by quantitative RT-PCR with specific primers for each of the three transcripts also demonstrated their different temporal patterns of expression. CONCLUSIONS/SIGNIFICANCE: The existence of an aggregation-specific promoter can be associated with the use of cAMP as chemo-attractant molecule, which is specific for some Dictyostelium species. Expression at late developmental stages indicates that adenylyl cyclase A might play a more important role in post-aggregative development than previously considered.

  13. COMPLICACIONES DE LA CIRUGÍA CARDÍACA VIDEO-ASISTIDA / Complications of video-assisted heart surgery

    Directory of Open Access Journals (Sweden)

    Fausto L. Rodríguez Salgueiro

    2012-01-01

    Full Text Available ResumenLa cirugía cardiovascular video-asistida incluye procedimientos extremadamente complejos, como la revascularización miocárdica y las sustituciones valvulares, no exentos de complicaciones fácilmente prevenibles y tratables. En este artículo se discuten las complicaciones de la cirugía cardíaca video-asistida, propias de la posición del paciente: respiratorias, cardiovasculares, quirúrgicas, infecciosas, entre otras. La cirugía cardíaca video-asistida brinda al paciente innumerables ventajas e implica un riesgo potencial de complicaciones evitables. El desarrollo de estos procedimientos es posible gracias a los adelantos tecnológicos y al diseño de nuevas técnicas anestésicas, ventilatorias, farmacológicas y de monitorización.AbstractThe video-assisted cardiac surgery includes extremely complex procedures such as myocardial revascularization and valve replacements, which are not exempt from easily preventable and treatable complications. In this article, the complications of video-assisted cardiac surgery, typical of patient positioning: respiratory, cardiovascular, surgical, infectious, among other complications, are discussed. The video-assisted cardiac surgery offers many advantages to the patient and involves a potential risk of avoidable complications. The development of these procedures is possible thanks to technological advances and the design of new anesthetic, ventilatory, pharmacologic and monitoring techniques.

  14. Synthesis of 2-aminocyclopent-1-ene-1-carbodithioic acid (ACA Capped Silver nanoparticles, Characterisation and Fluorescence application

    Directory of Open Access Journals (Sweden)

    M. Padma

    2015-02-01

    Full Text Available The present work deals with the formation, morphology and photophysical activity of the 2-aminocyclopent-1- ene-1-carbodithioic acid (ACA Capped Silver nanoparticles via chemical reduction method. The method utilizes a simple chemical reaction of silver idodide and sodium borohydride. The advantages of this method are ease of preparation, convenience in use and especially, that the obtained silver nano particles are uniform in their shapes and sizes. This is important for fluorescence & bio-evolution measurements. Furthermore, UVvisible (UV-vis spectroscopy is employed to monitor the formation process of the nano particles and to determine the optimum conditions for the preparation of stable and highly fluorescence-active silver colloids. Specifically, we observed changes in the shapes of the silver nano particles during the formation. This may be helpful in understanding the growth of the nano particles and creates a new dimension in controlling the shapes of the nano particles.SEM, TEM and XRD studies are carried out. The suitability of ACA capped Ag-NPs as Biomarkers is also Tested by Fluorescence study.

  15. Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA

    Directory of Open Access Journals (Sweden)

    Li Deng

    2016-01-01

    Full Text Available In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method.

  16. Instrumentos para valorar al paciente con insuficiencia cardíaca avanzada: una revisión de la literatura

    Directory of Open Access Journals (Sweden)

    J. Martín

    2015-12-01

    Full Text Available Una cuarta parte de las personas con insuficiencia cardíaca se encuentran en una etapa avanzada de la enfermedad durante la cual experimentan numerosos síntomas, comunes y angustiantes, que impactan en todas las esferas de la persona. En este contexto, la valoración y el seguimiento clínico de los pacientes se debe realizar de manera frecuente. A través de esta revisión, se pretende identificar cuáles son los instrumentos que se utilizan en la valoración de enfermos con insuficiencia cardíaca avanzada. Para este trabajo se ha considerado instrumento a cualquier tipo de cuestionario, escala, test o prueba funcional, que se utilice para valorar algún aspecto de estos enfermos. Se han identificado 49 herramientas que permiten valorar síntomas, aspectos psicológicos, cognitivos, espirituales y de calidad de vida. La información proporcionada sobre los instrumentos más utilizados y su disponibilidad y aplicabilidad constituye un primer paso para su posible integración en la práctica clínica diaria. De este modo, los profesionales que trabajan con estos enfermos, podrán mejorar la identificación de necesidades específicas, posibilitando el posterior manejo de las mismas y su seguimiento.

  17. Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Jing; Liang, Bo; Li, Hong (FSU)

    2010-09-17

    Box H/ACA ribonucleoprotein protein particles catalyze the majority of pseudouridylation in functional RNA. Different from stand alone pseudouridine synthases, the RNP pseudouridine synthase comprises multiple protein subunits and an RNA subunit. Previous studies showed that each subunit, regardless its location, is sensitive to the step of subunit placement at the catalytic center and potentially to the reaction status of the substrate. Here we describe the impact of chemical substitutions of target uridine on enzyme activity and structure. We found that 3-methyluridine in place of uridine inhibited its isomerization while 2{prime}-deoxyuridine or 4-thiouridine did not. Significantly, crystal structures of an archaeal box H/ACA RNP bound with the nonreactive and the two postreactive substrate analogues showed only subtle structural changes throughout the assembly except for a conserved tyrosine and a substrate anchoring loop of Cbf5. Our results suggest a potential role of these elements and the subunit that contacts them in substrate binding and product release.

  18. The Electrochemical Behavior of Au/AuNPs/PNA/ZnSe-QD/ACA Electrode Towards CySH Oxidation

    Institute of Scientific and Technical Information of China (English)

    Azadeh Azadbakht; Amir Reza Abbasi; Zohreh Derikvand; Ziba Karimi

    2015-01-01

    This work describes the electrochemical behavior of azodicarboxamide (ACA) film immobilized on the surface of penicillamine (PNA)/ZnSe-quantum dot (ZnSe-QD) gold nanoparticle (AuNPs) Au electrode. Electrocatalytic activity of modified electrode toward the oxidation of cysteine (CySH) was investigated. The surface structure and composition of the sensor were characterized by scanning electron microscopy (SEM). Oxidation of CySH on the surface of modified electrode was investigated with cyclic voltammetry, electrochemical impedance spectroscopy (EIS), hydrodynamic voltammetry and chronoamperometry methods. The results show that the PNA/ZnSe-QD/ACA film displays excellent electrochemical catalytic activities towards CySH oxidation. The modified electrode shows repro-ducible behavior and high level of stability during the electrochemical experiments. Also it has short response time, low detection limit, high sensitivity and low operation potential, which can be used as an amperometric sensor for moni-toring of CySH. The proposed modified electrode was successfully used for determination of CySH in real sample such as human serum.

  19. How the ACA's Health Insurance Expansions Have Affected Out-of-Pocket Cost-Sharing and Spending on Premiums.

    Science.gov (United States)

    Glied, Sherry; Solís-Román, Claudia; Parikh, Shivani

    2016-09-01

    One important benefit gained by the millions of Americans with health insurance through the Affordable Care Act (ACA) is protection from high out-of-pocket health spending. While Medicaid unambiguously reduces out-of-pocket premium and medical costs for low-income people, it is less certain that marketplace coverage and other types of insurance purchased to comply with the law's individual mandate also protect from high health spending. Goal: To compare out-of-pocket spending in 2014 to spending in 2013; assess how this spending changed in states where many people enrolled in the marketplaces relative to states where few people enrolled; and project the decline in the percentage of people paying high amounts out-of-pocket. Methods: Linear regression models were used to estimate whether people under age 65 spent above certain thresholds. Key findings and conclusions: The probability of incurring high out-of-pocket costs and premium expenses declined as marketplace enrollment increased. The percentage reductions were greatest among those with incomes between 250 percent and 399 percent of poverty, those who were eligible for premium subsidies, and those who previously were uninsured or had very limited nongroup coverage. These effects appear largely attributable to marketplace enrollment rather than to other ACA provisions or to economic trends.

  20. Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA

    Science.gov (United States)

    Deng, Li; Wang, Guohua; Yu, Suihuai

    2016-01-01

    In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm) were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method. PMID:26884745

  1. Enfermedad cardíaca grave en la esclerosis sistémica Severe cardiac disease in scleroderma

    Directory of Open Access Journals (Sweden)

    Alejandro R. Grinberg

    2004-10-01

    Full Text Available Una mujer de 36 años de edad con diagnóstico de esclerosis sistémica (ES desarrolló un cuadro agudo de miositis esquelética e insuficiencia cardíaca grave. Evolucionó con shock cardiogénico y a pesar del tratamiento con drogas inotrópicas y altas dosis de corticoides falleció a los cinco días de haber ingresado. La autopsia reveló áreas de necrosis coagulativa miocárdicas con miocitolisis y necrosis en banda de contracción. Son muy pocos los casos comunicados de insuficiencia cardíaca grave asociada a la ES.A 36 year-old female with a diagnosis of systemic sclerosis suffered from an acute episode of skeletal myositis and refractory heart failure with cardiogenic shock. Despite immunosuppressive treatment with high doses of corticosteroids and hemodynamic support she died five days after admission. The autopsy showed cardiac myocytolysis, myocyte necrosis and contraction band necrosis. There are very few reported cases of severe heart failure associated to systemic sclerosis.

  2. Probiotics supplementation for athletes - clinical and physiological effects.

    Science.gov (United States)

    Pyne, David B; West, Nicholas P; Cox, Amanda J; Cripps, Allan W

    2015-01-01

    Probiotic supplementation has traditionally focused on gut health. However, in recent years, the clinical applications of probiotics have broadened to allergic, metabolic, inflammatory, gastrointestinal and respiratory conditions. Gastrointestinal health is important for regulating adaptation to exercise and physical activity. Symptoms such as nausea, bloating, cramping, pain, diarrhoea and bleeding occur in some athletes, particularly during prolonged exhaustive events. Several studies conducted since 2006 examining probiotic supplementation in athletes or highly active individuals indicate modest clinical benefits in terms of reduced frequency, severity and/or duration of respiratory and gastrointestinal illness. The likely mechanisms of action for probiotics include direct interaction with the gut microbiota, interaction with the mucosal immune system and immune signalling to a variety of organs and systems. Practical issues to consider include medical and dietary screening of athletes, sourcing of recommended probiotics and formulations, dose-response requirements for different probiotic strains, storage, handling and transport of supplements and timing of supplementation in relation to travel and competition.

  3. Hip flexor strain - aftercare

    Science.gov (United States)

    ... flexor - aftercare; Hip flexor injury - aftercare; Hip flexor tear - aftercare; Iliopsoas strain - aftercare; Strained iliopsoas muscle - aftercare; Torn iliopsoas muscle - aftercare; Psoas strain - aftercare

  4. Vitamin supplementation in pregnancy.

    Science.gov (United States)

    2016-07-01

    Ensuring that a woman is well-nourished, both before and during pregnancy, is crucial for the health of the woman and that of the unborn child.(1) Maternal deficiency in key nutrients has been linked to pre-eclampsia, restricted fetal growth, neural tube defects, skeletal deformity and low birth weight.(1,2) Many nutritional supplements containing vitamins, minerals and other micronutrients are heavily marketed to women for all stages of pregnancy. However, much of the evidence for vitamin supplementation in pregnancy comes from studies carried out in low-income countries,(3) where women are more likely to be undernourished or malnourished than within the UK population. The challenges lie in knowing which supplements are beneficial and in improving uptake among those at most need. Here we summarise current UK guidance for vitamin supplementation in pregnancy and review the evidence behind it. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  5. Avaliação eletrofisiológica cardíaca em pacientes com sarcoidose Evaluación electrofisiológica cardíaca en pacientes con sarcoidosis Cardiac electrophysiological assessment in patients with sarcoidosis

    Directory of Open Access Journals (Sweden)

    Jefferson Curimbaba

    2011-04-01

    Full Text Available FUNDAMENTO: Sarcoidose é uma doença granulomatosa multissistêmica de origem desconhecida que pode causar morte súbita. OBJETIVO: Avaliação eletrofisiológica de pacientes com sarcoidose com suspeita de comprometimento cardíaco. MÉTODOS: Foram estudados 22 pacientes com média de idade de 55,32 ±13,13 anos, com diagnóstico de sarcoidose e suspeita de comprometimento cardíaco. Foram submetidos à avaliação clínica, exames laboratoriais, eletrocardiograma, ecocardiograma, Holter de 24h, cintilografia com gálio ou tecnécio e estudo eletrofisiológico. Em casos selecionados foi realizada tomografia por emissão de pósitrons ou ressonância magnética. Os pacientes foram seguidos ambulatoriamente com consultas trimestrais. RESULTADOS: Comprometimento cardíaco foi comprovado em quatro (18,2% pacientes. Extrassístoles ventriculares com densidade > 100/24h foram documentadas no Holter de 24h em 12 (54,5 % pacientes. O estudo eletrofisiológico revelou aumento do intervalo HV em sete (31,8% e ponto de Wenckebach aumentado em quatro (18,2% pacientes. Houve indução de fibrilação atrial em sete (31,8% e de taquicardia ventricular sustentada em um (4,5%. Nos quatro pacientes com sarcoidose cardíaca confirmada, extrassístoles ventriculares, com densidade > 100/24h foram documentadas em todos, dois apresentavam intervalo HV prolongado e fibrilação atrial foi induzida em dois. Taquicardia ventricular sustentada não foi induzida em nenhum desses pacientes. Após período médio de acompanhamento de 20,9 ± 15,7 meses, um paciente com sarcoidose cardíaca apresentou morte súbita. CONCLUSÃO: Pacientes com sarcoidose e suspeita de envolvimento cardíaco apresentam alta prevalência de EVs e distúrbios do sistema de condução.FUNDAMENTOS: Sarcoidosis es una enfermedad granulomatosa multisistémica de origen desconocido que puede causar la muerte súbita. OBJETIVOS:Evaluación electrofisiológica de los pacientes con sarcoidosis con

  6. Weight Loss Nutritional Supplements

    Science.gov (United States)

    Eckerson, Joan M.

    Obesity has reached what may be considered epidemic proportions in the United States, not only for adults but for children. Because of the medical implications and health care costs associated with obesity, as well as the negative social and psychological impacts, many individuals turn to nonprescription nutritional weight loss supplements hoping for a quick fix, and the weight loss industry has responded by offering a variety of products that generates billions of dollars each year in sales. Most nutritional weight loss supplements are purported to work by increasing energy expenditure, modulating carbohydrate or fat metabolism, increasing satiety, inducing diuresis, or blocking fat absorption. To review the literally hundreds of nutritional weight loss supplements available on the market today is well beyond the scope of this chapter. Therefore, several of the most commonly used supplements were selected for critical review, and practical recommendations are provided based on the findings of well controlled, randomized clinical trials that examined their efficacy. In most cases, the nutritional supplements reviewed either elicited no meaningful effect or resulted in changes in body weight and composition that are similar to what occurs through a restricted diet and exercise program. Although there is some evidence to suggest that herbal forms of ephedrine, such as ma huang, combined with caffeine or caffeine and aspirin (i.e., ECA stack) is effective for inducing moderate weight loss in overweight adults, because of the recent ban on ephedra manufacturers must now use ephedra-free ingredients, such as bitter orange, which do not appear to be as effective. The dietary fiber, glucomannan, also appears to hold some promise as a possible treatment for weight loss, but other related forms of dietary fiber, including guar gum and psyllium, are ineffective.

  7. Dietary Supplements: What Is Safe?

    Science.gov (United States)

    ... and side effects of dietary supplements Dietary supplement advertising and promotion Talking with your doctor about dietary ... Statistics Center Volunteer Learning Center Follow Us Twitter Facebook Instagram Cancer Information, Answers, and Hope. Available Every ...

  8. Vitamin Supplements: Healthy or Hoax?

    Science.gov (United States)

    ... Recognition & Awards Healthy Workplace Food and Beverage Toolkit Vitamin Supplements: Healthy or Hoax? Updated:Jun 12,2015 Can vitamin and mineral supplements really make you healthier? Overwhelmed ...

  9. SUPPLEMENT USE BY YOUNG ATHLETES

    Directory of Open Access Journals (Sweden)

    Jill Anne McDowall

    2007-09-01

    Full Text Available This paper reviews studies of supplement use among child and adolescent athletes, focusing on prevalence and type of supplement use, as well as gender comparisons. Supplement use among adult athletes has been well documented however there are a limited number of studies investigating supplement use by child and adolescent athletes. A trend in the current literature revealed that the most frequently used supplements are in the form of vitamin and minerals. While health and illness prevention are the main reasons for taking supplements, enhanced athletic performance was also reported as a strong motivating factor. Generally, females are found to use supplements more frequently and are associated with reasons of health, recovery, and replacing an inadequate diet. Males are more likely to report taking supplements for enhanced performance. Both genders equally rated increased energy as another reason for engaging in supplement use. Many dietary supplements are highly accessible to young athletes and they are particularly vulnerable to pressures from the media and the prospect of playing sport at increasingly elite levels. Future research should provide more direct evidence regarding any physiological side effects of taking supplements, as well as the exact vitamin and mineral requirements for child and adolescent athletes. Increased education for young athletes regarding supplement use, parents and coaches should to be targeted to help the athletes make the appropriate choices

  10. Trombocitopenia em cirurgia cardíaca: importância diagnóstica e prognóstica Thrombocytopenia in cardiac surgery: diagnostic and prognostic importance

    Directory of Open Access Journals (Sweden)

    Ederlon Rezende

    2011-03-01

    Full Text Available OBJETIVO: Pacientes submetidos à cirurgia cardíaca estão mais propensos a desenvolver plaquetopenia. A trombocitopenia induzida por heparina acomete cerca de 5% dos pacientes. O objetivo foi avaliar a importância clínica da trombocitopenia grave em pacientes no pós-operatório de cirurgia cardíaca. MÉTODOS: Estudo prospectivo observacional que incluiu os pacientes de cirurgia cardíaca com plaquetas 6. A mortalidade na Unidade de Terapia Intensiva (UTI e hospitalar, o tempo de internação, os escores de gravidade e a incidência de tromboses foram comparados em pacientes com escore e" 6 (grupo 1 e 6, em pacientes no pós-operatório de cirurgia cardíaca, está associado a maior incidência de trombose, assim como o maior escore está relacionado à elevada mortalidade hospitalar.OBJECTIVE: Patients undergo to cardiac surgery have more probability to develop thrombocytopenia. The heparin induced thrombocytopenia happens in 5% of the patients. The aim from this study was to evaluate the clinical importance from the severe thrombocytopenia in postoperative cardiac surgical patients. METHODS: It was included cardiac surgical patients with platelets 6 (group 1 and 6, in postoperative cardiac surgical patients, it is associated to higher incidence of thrombosis as well as the greater score is related to higher hospital mortality rate.

  11. 279. El derrame pericárdico postoperatorio en cirugía cardíaca: Incidencia e impacto en los resultados quirúrgicos

    Directory of Open Access Journals (Sweden)

    E. Sandoval

    2012-04-01

    Conclusión: La ecocardiografía es una exploración inocua que permite el diagnóstico rápido de DP potencialmente letal, que tiene un componente medicolegal. Debe realizarse a todo postoperado de cirugía cardíaca.

  12. 197. Trombosis masiva biauricular intervenida mediante cirugía cardíaca con circulación extracorpórea

    Directory of Open Access Journals (Sweden)

    R. Sánchez Pérez

    2012-04-01

    Conclusión: Destacamos la importancia del diagnóstico precoz y preciso de la trombosis biauricular con embolismo paradójico en aurícula izquierda a través de fosa oval, en el contexto de trombosis venosa profunda, debido a que puede beneficiarse de la cirugía cardíaca como tratamiento inicial.

  13. 207. Terapia de resincronización cardíaca en la práctica clínica diaria. seguimiento a medio plazo

    Directory of Open Access Journals (Sweden)

    N. Miranda

    2012-04-01

    Conclusiones: La TRC es una terapia eficaz en el tratamiento de los pacientes con insuficiencia cardíaca refractaria al tratamiento convencional en nuestro medio. Es fundamental una correcta selección de los pacientes que van a ser sometidos a dicha terapia con vistas a mejorar la efectividad de ésta.

  14. Hospital discharge plan for patients with congestive heart failure Plan del alta hospitalaria para pacientes con insuficiencia cardíaca congestiva Plano de alta hospitalar a pacientes com insuficiência cardíaca congestiva

    Directory of Open Access Journals (Sweden)

    Maria Paula Andrietta

    2011-12-01

    Full Text Available This integrative review investigates how nurses plan the hospital discharge of patients with Congestive Heart Failure (CHF since an inadequate discharge plan and patients’ subsequent non-adherence to instruction provided upon discharge are indicated as potential factors for re-hospitalization. A total of 24 papers were found in a search carried out in the LILACS and MEDLINE databases between 2004 and 2008, which given the inclusion criteria, were reduced to 14 papers. The papers were analyzed and categorized into ‘Health Education’, and ‘Nursing Care’. The synthesis of results indicates that the discharge plan devised by nurses is based on two categories. The actions of nurses to promote health education can enable patients with CHF to improve self-care.Artículo de revisión integradora que tiene por objetivo identificar como las enfermeras han planificado el alta de los pacientes con Insuficiencia Cardíaca Congestiva, ya que el plan de alta inadecuado y el no seguimiento de las orientaciones dadas son apuntados como posibles factores de rehospitalización. A través de la búsqueda en las bases de datos LILACS y MEDLINE, abarcando el período de 2.004 a 2.008, fueron encontrados 24 artículos, que por el criterio de selección de la muestra resultaron en 14. Los artículos fueron analizados y categorizados en Educación en Salud y Cuidado de Enfermería. Con eso fue posible sintetizar los resultados e identificar que el plan de alta realizado por los enfermeros está basado en estas dos categorías, ya que a través de las conductas del enfermero para promover la educación en salud será posible proporcionar al paciente con Insuficiencia Cardíaca Congestiva una mejoría en el autocuidado.Trata-se de artigo de revisão integrativa que teve por objetivo identificar como as enfermeiras têm planejado a alta dos pacientes com insuficiência cardíaca congestiva, pois o inadequado plano de alta e o não seguimento das orienta

  15. Há evidências favorecendo o uso de betabloqueadores e dobutamina na insuficiência cardíaca aguda?

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Santana Passos

    2013-02-01

    Full Text Available Diversos estudos relataram os benefícios dos betabloqueadores (BB para pacientes com insuficiência cardíaca sistólica. No entanto, muitos pacientes hospitalizados em decorrência de insuficiência cardíaca aguda já estão usando os BB e requerem dobutaminas para hipotensão arterial e baixo débito cardíaco. Portanto, deve-se tomar uma decisão a respeito de se o BB deve ser mantido ou até mesmo iniciado nesses casos. O objetivo deste estudo foi determinar se há provas que sustentem a segurança e a eficácia dos BB junto com a dobutamina para pacientes com insuficiência cardíaca aguda descompensada (ICAD. Foi realizada uma pesquisa na literatura de língua inglesa nas bases de dados MEDLINE, ISI Web of Science, Biblioteca Virtual em Saúde, Cochrane Library e o Portal de Revistas Científicas do Capes para identificar estudos relacionados. Literatura adicional foi obtida mediante a análise das respectivas referências encontradas nos artigos identificados. Os resultados esperados incluíram informações sobre o prognóstico (intra-hospitalar e na mortalidade no acompanhamento, número de dias de internação e reinternação, eficácia e segurança (agravamento dos sintomas, choque, intolerância do uso concomitante desses medicamentos em pacientes hospitalizados com ICAD e baixo débito cardíaco. Esta análise incluiu nove estudos. No entanto, não foram encontrados ensaios clínicos randomizados sobre o assunto. A maioria dos estudos inclui baixo número de pacientes, e não foram encontrados estudos que abordem a segurança do uso concomitante desses medicamentos. Os dados resultantes sugerem que uma cuidadosa revisão da literatura não forneceu evidências para o uso sistemático de BB em pacientes com síndrome de baixo débito cardíaco que necessitam de suporte inotrópico com dobutamina.

  16. Long-term outcome of medial rectus recession and pulley posterior fixation in esotropia with high AC/A ratio.

    Science.gov (United States)

    Wabulembo, Geoffrey; Demer, Joseph L

    2012-09-01

    Medial rectus (MR) recession with pulley posterior fixation (PF) can be used to treatesotropia (ET) with a high accommodative convergence to accommodation (AC/A) ratio as effectively in the short term as MR recession with scleral PF. This study provides a novel examination of the long-term results of MR recession with pulley PF (PPF). In 21 children we performed bilateral MR recession and pulley PF for ET greater at near than distance (high AC/A). Mean follow-up was 3.5 ± 2.5 (standard deviation [SD]) years. Mean age at presentation was 2.7 ± 1.8 and at surgery 4.3 ± 1.6 years. Fourteen (67%) children had amblyopia. Distance and near pre-operative ET averaged 19.6Δ ± 10.5Δ and 36.9Δ ±18.9Δ, respectively. Mean near-distance (N-D) disparity was 16.4Δ ± 12.3Δ. The MR recession averaged 4.4 ± 0.9 mm. Early mean postoperative ET was 1.3 ± 3.3Δ at distance and 2.8Δ ± 5.2Δ at near. Mean late postoperative ET was 0.1Δ ± 5.8Δ and 1.0Δ ± 6.2Δ at distance and near, respectively. At the final postoperative examination, mean N-D disparity was reduced to 0.9Δ ± 3.6Δ. MR recession with PPF has a high long-term effectiveness, even in patients with amblyopia and autism. Since no posterior scleral suturing is required, it minimizes the perforation risk associated with scleral PF. MR recession with PPF is a safe and highly effective long-term treatment for ET with high AC/A ratio. Long-term results may surpass those of alternate procedures.

  17. Manejo ambulatorio de la insuficiencia cardíaca crónica en la Argentina: Estudio OFFICE IC

    Directory of Open Access Journals (Sweden)

    Jorge Thierer

    2006-01-01

    Full Text Available Objetivo Conocer las características basales y las modalidades diagnósticas y terapéuticas habituales en el tratamiento de pacientes con insuficiencia cardíaca crónica en la Argentina. Material y métodos Fueron encuestados 241 médicos de todo el país (91,7% cardiólogos, cada uno de los cuales comunicó datos referidos al perfil clínico, estudios realizados y tratamiento de pacientes con insuficiencia cardíaca crónica en seguimiento ambulatorio. Resultados Se obtuvieron datos de 2.201 pacientes (64,6% hombres, edad media 67,6 ± 12 años entre junio de 2003 y marzo de 2004. El 58% habían sido internados por insuficiencia cardíaca en los 2 años previos. Se encontraban en CF I-II el 73,5% de los pacientes. Las etiologías predominantes fueron la isquémica (40,5% y la hipertensiva (23,7%. En el 88,5% de los pacientes se conocía la función ventricular (disfunción sistólica moderada a severa en más del 70%. Estaban medicados con digital el 33%, con inhibidores de la enzima convertidora y/o antagonistas de la angiotensina II el 92,2%, con betabloqueantes el 70% y con espironolactona el 61,7%. La etiología, la función ventricular, la cobertura médica y el tratamiento concomitante fueron predictores del uso de antagonistas neurohormonales. Conclusiones Los pacientes incluidos son similares a los de otros registros poblacionales, con predominio de hombres y etiología isquémica e hipertensiva. La mayor parte de los pacientes presentó disfunción sistólica. El tratamiento de acuerdo con los estándares de las guías actuales se cumplió en una elevada proporción de pacientes.

  18. Seismic ambient noise H/V spectral ratio using the ACA (autocorrelations of coda of autocorrelations) approach

    Science.gov (United States)

    Sanchez-Sesma, F. J.; Piña, J.; Campillo, M.; Luzón, F.; García-Jerez, A.; Albarello, D.; Lunedei, E.

    2012-12-01

    The seismic ambient noise horizontal-to-vertical spectral ratios (NHVSR) are valuable for microzonation, and seismic prospecting. This is particularly true for low-cost dense spatial sampling projects. Arai and Tokimatsu (2004) proposed to use average energy densities to compose the ratios. It means that H/V comes from the square root of the ratio of averages. On the other hand, a popular approach makes the average of spectral ratios. For ergodic processes peak values are usually the same using these two approaches. Sometimes however, the observations are insufficient and computed values for low frequencies display large variability and the corresponding H/V estimates may be inaccurate. The bias caused by localized sources may be the source of errors in the estimates. In this work we propose to compute the NHVSR using the Autocorrelations of Coda of Autocorrelations. This ACA approach is inspired in the work by Stehly et al. (2008). They used the Correlations of Coda of Correlations (C3) to isotropize the field. In our ACA approach the whole time series, say of 30 minutes, for each component is autocorrelated and the averages of the spectral density of selected windows (late coda windows are eliminated) are then improved estimates of directional energy densities. The computation of NHVSR using ACA appears more stable and free of transient effects. It remains to establish how this may be accounted for in forward calculation of H/V spectral ratios for models like a layered medium (e.g. Sánchez-Sesma et al., 2011; Albarello and Lunedei, 2011). This will require further scrutiny. References. Albarello, D. & E. Lunedei (2011). Structure of ambient vibration wavefield in the frequency range of engineering interest ([0.5, 20] Hz): insights from numerical modelling. Near Surface Geophysics 9, 543-559. Arai, H. & K. Tokimatsu (2004). S-wave velocity profiling by inversion of microtremor H/V spectrum, Bull. Seismol. Soc. Am. 94, 53-63. Sánchez-Sesma, F. J., M. Rodr

  19. Avaliação por ressonância magnética de massas cardíacas

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Braggion-Santos

    2013-09-01

    Full Text Available FUNDAMENTO: Tumores cardíacos são extremamente raros; no entanto, quando há suspeita clínica, é necessária a correta avaliação diagnóstica, para planejar o tratamento mais adequado. Nesse contexto, a ressonância magnética cardiovascular tem um papel importante, permitindo uma abrangente caracterização de tais lesões. OBJETIVO: Revisar os casos encaminhados a um Serviço de Ressonância Magnética para investigação de massas cardíacas e paracardíacas. Descrever a série de casos positivos, juntamente de uma breve revisão da literatura para cada tipo de lesão e sobre o papel da ressonância magnética cardiovascular em sua avaliação. MÉTODOS: Entre agosto de 2008 e dezembro de 2011, foram revistos todos os casos de pacientes encaminhados a ressonância magnética com suspeita de neoplasia envolvendo o coração. Foram selecionados aqueles com confirmação histopatológica, evolução ou resposta terapêutica compatíveis com a suspeita clínica e achados de imagem. RESULTADOS: Entre os 13 pacientes incluídos neste estudo, oito (62% tiveram confirmação histopatológica. Foram descritas cinco neoplasias benignas (mixomas, rabdomioma e fibromas, cinco neoplasias malignas (sarcoma, linfoma, síndrome de Richter cardíaca e doença metastática e três lesões não neoplásicas (cisto pericárdico, trombo intracardíaco e vegetação infecciosa. CONCLUSÃO: A informação disponível sobre essa questão é escassa. Estudos prospectivos adicionais são necessários para elucidar o papel desses nutrientes no risco cardiovascular de pacientes com diabetes.

  20. Food Components and Supplements

    DEFF Research Database (Denmark)

    Parlesak, Alexandr

    2012-01-01

    The major part of food consists of chemical compounds that can be used for energy production, biological synthesis, or maintenance of metabolic processes by the host. These components are defined as nutrients, and can be categorized into macronutrients (proteins, carbohydrates, triglycerides......, and alcohol), minerals, and micronutrients. The latter category comprises 13 vitamins and a hand full of trace elements. Many micronutrients are used as food supplements and are ingested at doses exceeding the amounts that can be consumed along with food by a factor of 10–100. Both macro- and micronutrients....... The supplements and contaminants can compete directly with drug oxidation, induce or suppress the expression of xenobiotic-metabolizing enzymes, change the bioavailability of drugs, and, in the case of live bacteria, bring in their own xenobiotic metabolism, including cytochrome P450 (CYP) activity. In numerous...

  1. Effective Nutritional Supplement Combinations

    Science.gov (United States)

    Cooke, Matt; Cribb, Paul J.

    Few supplement combinations that are marketed to athletes are supported by scientific evidence of their effectiveness. Quite often, under the rigor of scientific investigation, the patented combination fails to provide any greater benefit than a group given the active (generic) ingredient. The focus of this chapter is supplement combinations and dosing strategies that are effective at promoting an acute physiological response that may improve/enhance exercise performance or influence chronic adaptations desired from training. In recent years, there has been a particular focus on two nutritional ergogenic aids—creatine monohydrate and protein/amino acids—in combination with specific nutrients in an effort to augment or add to their already established independent ergogenic effects. These combinations and others are discussed in this chapter.

  2. Unmanned Aircraft Systems (UAS) Integration in the National Airspace System (NAS) Project: Advanced Collision Avoidance System for UAS (ACAS Xu) Interoperability White Paper Presentation

    Science.gov (United States)

    Fern, Lisa

    2017-01-01

    The Phase 1 DAA Minimum Operational Performance Standards (MOPS) provided requirements for two classes of DAA equipment: equipment Class 1 contains the basic DAA equipment required to assist a pilot in remaining well clear, while equipment Class 2 integrates the Traffic Alert and Collision Avoidance (TCAS) II system. Thus, the Class 1 system provides RWC functionality only, while the Class 2 system is intended to provide both RWC and Collision Avoidance (CA) functionality, in compliance with the Minimum Aviation System Performance (MASPS) for the Interoperability of Airborne Collision Avoidance Systems. The FAAs TCAS Program Office is currently developing Airborne Collision Avoidance System X (ACAS X) to support the objectives of the Federal Aviation Administrations (FAA) Next Generation Air Transportation System Program (NextGen). ACAS X has a suite of variants with a common underlying design that are intended to be optimized for their intended airframes and operations. ACAS Xu being is designed for UAS and allows for new surveillance technologies and tailored logic for platforms with different performance characteristics. In addition to Collision Avoidance (CA) alerting and guidance, ACAS Xu is being tuned to provide RWC alerting and guidance in compliance with the SC 228 DAA MOPS. With a single logic performing both RWC and CA functions, ACAS Xu will provide industry with an integrated DAA solution that addresses many of the interoperability shortcomings of Phase I systems. While the MOPS for ACAS Xu will specify an integrated DAA system, it will need to show compliance with the RWC alerting thresholds and alerting requirements defined in the DAA Phase 2 MOPS. Further, some functional components of the ACAS Xu system such as the remote pilots displayed guidance might be mostly references to the corresponding requirements in the DAA MOPS. To provide a seamless, integrated, RWC-CA system to assist the pilot in remaining well clear and avoiding collisions, several

  3. [ERGOGENIC SPORT SUPPLEMENTS FOR ATHLETES].

    Science.gov (United States)

    Arieli, Rakefet; Lahav, Yair

    2016-06-01

    Use of performance-enhancing supplements occurs at all levels of sports, from recreational athletes to professional athletes. Although some supplements do enhance athletic performance, many have no proven benefits and have adverse effects. Nutritional supplements are categorized into the following categories: I. Apparently Effective. II. Possibly Effective. III. Too Early To Tell. IV. Apparently Ineffective. This article will review 4 ergogenic supplements which are categorized in the first category--"Apparently Effective"--1) Buffer agents 2) Creatine 3) Caffeine and 4 Nitric Oxide. Given the widespread use of performance enhancing supplements, physicians, and dietitians should be prepared to counsel athletes about their effectiveness, safety and legality.

  4. Supplemental topics on voids

    Energy Technology Data Exchange (ETDEWEB)

    Rood, H.J.

    1988-09-01

    Several topics concerning voids are presented, supplementing the report of Rood (1988). The discovery of the Coma supercluster and void and the recognition of the cosmological significance of superclusters and voids are reviewed. Galaxy redshift surveys and redshift surveys for the Abell clusters and very distant objects are discussed. Solar system and extragalactic dynamics are examined. Also, topics for future observational research on voids are recommended. 50 references.

  5. Incidência de cirurgia cardíaca em octogenários: estudo retrospectivo Incidencia de cirugía cardíaca en octogenarios: estudio retrospectivo Incidence of cardiac surgery in octogenarian patients: retrospective study

    Directory of Open Access Journals (Sweden)

    Luciano Brandão Machado

    2003-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O aumento da expectativa de vida faz com que pacientes cada vez mais idosos tenham indicação de tratamento cirúrgico de cardiopatias. Este estudo tem como objetivo avaliar a incidência de pacientes com mais de 80 anos submetidos à cirurgia cardíaca no Instituto do Coração do Hospital das Clínicas da FMUSP, nos últimos 16 anos. MÉTODO: Foram analisados, no período de 1986 a 2001, o número de cirurgias de revascularização do miocárdio (RM e cirurgia valvar (CV e, em cada grupo, o número de cirurgias em pacientes com mais de 80 anos. Os dados foram analisados descritivamente. RESULTADOS: Os dados revelam aumento progressivo do número de octogenários submetidos à cirurgia cardíaca. As cirurgias de revascularização do miocárdio tiveram aumento de 0,13% em 1986 para 3,5% em 2001. As cirurgias valvares aumentaram de 0% em 1986 para 1,44% em 2001, registrando o maior valor de 3,02% em 1999. CONCLUSÕES: Os conhecimentos da fisiopatologia, da senilidade e os avanços no manuseio do trauma cirúrgico estão permitindo estender os recursos da cirurgia cardíaca no grupo de paciente mais idoso. A escolhas da técnica anestésica deve ser criteriosa, bem como a hidratação, a assistência ventilatória e a analgesia pós-operatória, permitindo redução da morbimortalidade neste grupo de maior risco cirúrgico.JUSTIFICATIVA Y OBJETIVOS: El aumento de la expectativa de vida hace con que pacientes cada vez mas edosos tengan indicación de tratamiento quirúrgico de cardiopatias. Este estudio tiene como objetivo evaluar la incidencia de pacientes con más de 80 años sometidos a cirugía cardíaca en el Instituto del Corazón del Hospital de Clínicas de la FMUSP, en los últimos 16 años. MÉTODO: Fueron analizados, en el período de 1986 a 2001, el número de cirugías de revascularización del miocardio (RM y cirugía valvar (CV y, en cada grupo, el número de cirugías en pacientes con más de 80 a

  6. Variabilidade da frequência cardíaca em neonatos prematuros e de termo Variabilidad de la frecuencia cardíaca en neonatos prematuros y de término Heart rate variability in preterm and term neonates

    Directory of Open Access Journals (Sweden)

    Fabio Augusto Selig

    2011-06-01

    Full Text Available FUNDAMENTO: Várias publicações têm demonstrado a importância do sistema nervoso autônomo por meio dos componentes simpático e parassimpático na gerência da interação entre as diferentes partes do organismo humano. Esses estudos aplicaram técnicas lineares e não lineares (Teoria do Caos de avaliação em diferentes situações, doenças e faixas etárias, tendo como ferramenta a variabilidade da frequência cardíaca (VFC. OBJETIVO: Aplicar os conhecimentos das dinâmicas linear e não linear na avaliação de neonatos prematuros (NPT, analisando sua VFC e comparando com neonatos de termo (NT saudáveis. MÉTODOS: Quarenta e oito neonatos prematuros com diferentes idades gestacionais tiveram seus batimentos cardíacos captados com auxílio do equipamento Polar Advanced S810i e sua VFC obtida pelo registro dos intervalos RR. A VFC foi analisada nos domínios do tempo (SDNN, RMSSD, SD1/SD2, da frequência (VLF, LF, HF e a relação LF/HF e do caos (TAU e sua normalização [TAU(n], Expoente de Lyapunov e Entropia. Os NPT foram comparados com um grupo de 78 NT saudáveis e sem intercorrências perinatais com auxílio do teste não paramétrico de Kruskal-Wallis. RESULTADOS: Detectou-se diferença estatisticamente significante entre os grupos para todas as variáveis estudadas, tanto no domínio do tempo como nos da frequência e do caos. CONCLUSÃO: Neonatos prematuros exibem comportamento menos complexo da variabilidade da frequência cardíaca que neonatos de termo, fato comprovado nos domínios do tempo, da frequência e do caos. O estudo da variabilidade cardíaca nesse grupo pode ser considerado uma ferramenta a mais na avaliação da maturação autonômica e, consequentemente, da progressão para eutrofia.FUNDAMENTO: Varias publicaciones han demostrado la importancia del sistema nervioso autónomo por medio de los componentes simpático y parasimpático en el manejo de la interacción entre las diferentes partes del organismo

  7. O trabalho da enfermagem no pós-operatório de cirurgia cardíaca: uma revisão integrativa

    Directory of Open Access Journals (Sweden)

    Ana Paula Azevedo Santos

    2015-05-01

    Full Text Available Este estudo teve o objetivo de identificar, por meio de produções científicas nacionais e internacionais, os cuidados desenvolvidos pela equipe de enfermagem durante a assistência ao paciente no pósoperatório de cirurgia cardíaca. Trata-se de uma revisão integrativa realizada por meio de busca às bases PubMed, LILACS, CINAHL, SCOPUS e BDENF no período de fevereiro a junho de 2014, com o seguinte questionamento: “Quais os cuidados realizados pela equipe de enfermagem ao paciente no pós-operatório de cirurgia cardíaca?” Utilizou-se como critério de inclusão artigos científicos publicados nos últimos cinco anos, em português, inglês e espanhol, disponíveis na íntegra. Foram selecionados 21 artigos e, mediante a sua leitura criteriosa, foi realizada análise descritiva, possibilitando o agrupamento dos dados em um núcleo temático: cuidando do paciente no pós-operatório de cirurgia cardíaca, que apontou subcategorias: assistindo o paciente após cirurgia cardíaca, gerenciando a dor e a comunicação como ferramenta no cuidado de enfermagem. Os cuidados desenvolvidos no pós-operatório de cirurgia cardíaca demonstram a necessidade de organização do processo de trabalho da equipe de enfermagem bem como competências específicas dos profissionais para atuarem nesse cenário, com intuito de promover um cuidado individualizado e qualificado.

  8. Suporte ventilatório na capacidade funcional de pacientes com insuficiência cardíaca: estudo piloto

    Directory of Open Access Journals (Sweden)

    Eugênia da Silva Lima

    2011-03-01

    Full Text Available FUNDAMENTO: A insuficiência cardíaca é um importante problema de saúde pública, apresentando a dispneia e a fadiga como principais sintomas clínicos. A utilização do suporte ventilatório não invasivo vem atuando como coadjuvante da reabilitação cardíaca na tentativa de melhorar a capacidade funcional dos pacientes. OBJETIVO: Avaliar a capacidade funcional de pacientes com insuficiência cardíaca submetidos ao suporte ventilatório. MÉTODOS: Foram avaliados dados sociodemográficos, qualidade de vida, FC, pressão arterial (PA, saturação periférica de oxigênio (SpO2, dispneia, concentração de lactato, antes e depois do teste de caminhada de 6 minutos, e a distância percorrida de pacientes com insuficiência cardíaca crônica (ICC, de ambos os sexos, com fração FEVE < 45,0%, randomizados em dois grupos: controle e CPAP (utilizou CPAP 10 cmH2O por 30 minutos. RESULTADOS: Participaram 12 pacientes com ICC classe funcional II e III (NYHA, com média de fração de ejeção do ventrículo esquerdo (FEVE, % de 35,3 ± 8,7, sendo que 8 eram do sexo masculino. A média de idade foi de 46,3 ± 10,3 anos. Na comparação entre os grupos Controle e CPAP, no final do 6º min, foi encontrada diferença significativa nos valores de SpO2% entre os grupos (Controle: 93,6 ± 1,5 % vs CPAP: 96,1 ± 1,8%; p = 0,027, dispneia (Controle: 13,1 ± 1,16 vs CPAP: 11 ± 0,8; p = 0,009, concentração de lactato (Controle: 3,3 ± 0,7 mmol/l vs CPAP: 2,3 ± 0,5 mmol/l; p = 0,025, e distância percorrida no TC6 (Controle: 420,6 ± 73,8 m vs CPAP: 534 ± 89,91 m; p = 0,038. CONCLUSÃO: A realização prévia do CPAP apresentou efeitos benéficos na SpO2, na dispneia, na concentração de lactato, no duplo produto e na distância percorrida no TC6 de pacientes com ICC na realização do TC6.

  9. Patologia cardíaca: novos biomarcadores associados ao diagnóstico e prognóstico

    OpenAIRE

    Matias, António Pedro Laranjo

    2012-01-01

    Dissertação de mest., Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2012 As patologias cardíacas afetam cada vez mais indivíduos em todo o mundo, sendo uma das principais causas de debilitação e morte. Podem ter um caráter crónico ou agudo, sendo essencial uma eficaz deteção e acompanhamento da evolução das mesmas. Com este trabalho de revisão bibliográfica pretende-se mostrar a utilidade de substâncias participantes de processos fisiológicos endógenos co...

  10. Células troncales (stem cells y regeneración cardíaca Stem cells and cardiac regeneration

    Directory of Open Access Journals (Sweden)

    María Inés Pérez Millán

    2006-12-01

    Full Text Available Las células troncales carecen de marcadores de diferenciación, tienen gran capacidad proliferativa, pueden automantener la población, producen progenies de células progenitoras y participan en la regeneración de tejidos. Los tejidos de un individuo tienen capacidad de regeneración, que a veces está ligada a la presencia de células troncales. La medicina regenerativa plantea la terapia celular como una alternativa para el tratamiento de diversas enfermedades, incluyendo las cardíacas (cardiomioplastia celular. Las células a usar pueden provenir de distintas fuentes, entre ellas las células troncales de origen cardíaco o extracardíaco. La médula ósea es una de las fuentes más importantes de células troncales extracardíacas, que podrían contribuir a obtener células cardíacas por diversos mecanismos (transdiferenciación, fusión o transferencia a través de estructuras nanotubulares. En los últimos años, diversas publicaciones refieren la existencia de células troncales nativas cardíacas, caracterizadas por la presencia de distintos marcadores. Se plantea también la alternativa del uso de factores de crecimiento para producir la movilización de células troncales. El individuo adulto posee células con alta potencialidad, surgidas en estadios embrionarios antes o después de la determinación en las capas germinales, y mantenidas hasta la adultez que, bajo condiciones apropiadas de manipulación, permita su utlización en la medicina regenerativa.Stem cells are defined by virtue of their functional attributes: absence of tissue specific differentitated markers, capable of proliferation, able to self-maintain the population, able to produce a large number of differentiated, functional progeny, able to regenerate the tissue after injury. Cell therapy is an alternative for the treatment of several diseases, like cardiac diseases (cell cardiomyoplasty. A variety of stem cells could be used for cardiac repair: from cardiac and

  11. Factores asociados al patrón de sueño en pacientes con insuficiencia cardíaca

    OpenAIRE

    Mariana Alvina dos Santos; Diná de Almeida Lopes Monteiro da Cruz; Ricardo Luís Barbosa

    2011-01-01

    O estudo teve como objetivo descrever o padrão de sono em pacientes com insuficiência cardíaca (IC) e analisar associações do sono com as seguintes variáveis: sexo, idade, fadiga, fadiga ao esforço, atividade física, classe funcional, terapia medicamentosa, dispneia e índice de massa corporal. A amostra não probabilística foi de 400 pacientes (idade média 57,8 anos; 64,8% eram homens; escolaridade média de 6,1 anos; 82,5% em classe funcional II ou III). A prevalência de maus dormidores foi de...

  12. Recomendaciones terapéuticas en la insuficiencia cardíaca Therapeutic recommendations in heart failure

    Directory of Open Access Journals (Sweden)

    Annery Luis Martínez

    2003-12-01

    Full Text Available Se presentan algunas recomendaciones terapéuticas para el tratamiento de la insuficiencia cardíaca (IC. Esta se ha convertido en un creciente problema de salud, debido al envejecimiento poblacional y al aumento de la supervivencia de las pacientes cardiópatas. Las opciones terapéuticas que se aconsejan están encaminadas a lograr una mejor calidad de vida del paciente, para lo cual es vital el entendimiento de los procesos fisiopatológicos de esta enfermedad.Some therapeutic recommendations for the treatment of heart failure are made. It has become an increasing health problem due to the population aging and to the rise of survival among cardiopathic patients. The recommended therapeutic options are directed to attain a better quality of life of the patients, for which the comprehension of the physiopathological processes of this disease is vital.

  13. La estimulación cardíaca, camino de la certificación en calidad

    Directory of Open Access Journals (Sweden)

    Fernando Hornero

    2007-07-01

    Full Text Available La Sociedad Española de Cardiología (SEC ha anunciado la puesta en marcha por hospitales de un proceso de acreditación de la estimulación cardíaca. La propia SEC la otorgará de forma provisional y una agencia externa, de forma definitiva. El certificado de calidad es un sello de distinción que acredita el nivel alcanzado por una organización. En el caso de la propuesta de la SEC, los cirujanos cardiovasculares deben reflexionar y posicionarse acerca de la misma por sus implicaciones prácticas. Con independencia de la legitimidad de la propuesta, se echa en falta una participación intersocietaria que, además de buscar la mejora de calidad, facilite las relaciones de todos los profesionales involucrados en el proceso asistencial.

  14. Estudo in vivo do efeito agudo da espironolactona e eplerenona em ratos submetidos à isquemia cardíaca.

    OpenAIRE

    2013-01-01

    Programa de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa e Pós Graduação, Universidade Federal de Ouro Preto. O aumento dos níveis plasmáticos de aldosterona após infarto do miocárdio (IM) está relacionado com a piora do prognóstico da doença e contribui para patogênese da insuficiência cardíaca. O tratamento do IM com antagonistas de receptores mineralocorticoides (MR) da aldosterona, espironolactona e eplerenona, têm reduzido ...

  15. Anemia da doença crónica na insuficiência cardíaca

    OpenAIRE

    Carvalho, Ângelo Miguel Crisóstomo

    2014-01-01

    Trabalho final de mestrado integrado em Medicina (Geriatria), apresentado á Faculdade de Medicina da Universidade de Coimbra A insuficiência cardíaca é uma das doenças mais prevalentes a nível mundial, especialmente no idoso, e apesar dos avanços médicos na prevenção de doenças cardiovasculares e nos arsenais terapêuticos, estima-se que a sua prevalência aumente em 50-75% até ao final de 2030 e o número de hospitalizações em 50% nos próximos 25 anos. Uma das suas complicações de maior impo...

  16. Lesão neurológica em cirurgia cardíaca: aspectos fisiopatológicos

    OpenAIRE

    Rólison Gustavo Bravo Lelis; José Otávio Costa Auler Júnior

    2004-01-01

    JUSTIFICATIVA E OBJETIVOS: Em virtude de as lesões neurológicas ocuparem um papel importante no contexto das complicações pós-operatórias, quando comparadas às demais, o presente estudo procurou discutir os principais fatores envolvidos na lesão neurológica peri-operatória em cirurgia cardíaca, as intervenções que buscam diminuir a incidência de lesões neurológicas, enfocando de maneira simples, e a provável gênese genética em tais lesões encefálicas. CONTEÚDO: Este trabalho contém a revisão ...

  17. Aspectos psicosociales de la enfermedad celíaca en España: una vida libre de gluten

    Directory of Open Access Journals (Sweden)

    Julián Rodríguez ALMAGRO

    Full Text Available RESUMEN Objetivo: La celiaquía como enfermedad crónica tiene una alta prevalencia en nuestra sociedad. El artículo analiza los aspectos psicosociales de la enfermedad celíaca en los diferentes entornos, valorando el impacto de la implantación de una dieta estricta libre de gluten. Métodos: Estudio cualitativo entre los meses de Enero del 2013 a Abril del 2013 en el cual, a través de la teoría fundamentada y el análisis de contenido, se ha profundizado en el análisis de las entrevistas semiestructuradas a personas con enfermedad celíaca en España. Se realizaron llamamientos a traves de las redes sociales y grupos de celíacos hasta llegar a la saturación teórica, que determinó el tamaño final de la muestra de 24 personas. Resultados: Educación Sanitaria, Aislamiento social, soledad y desconocimiento social emergieron como categorías centrales en la experiencia de adopción de la dieta libre de gluten a partir del diagnóstico de celiaquía. Conclusión: Los profesionales deben promover y apoyar estrategias de apoyo social basadas en una comprensión íntegra de las experiencias de desarraigo y marginación que los pacientes celíacos experimentan en sus relaciones sociales a través de la comida. Se requiere un aumento de la educación sanitaria para entender e integrar el impacto psicosocial del diagnóstico de celiaquía y la dieta libre de gluten.

  18. Ansiedade no período pré-operatório de cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Karyne Kirley Negromonte Gonçalves

    2016-04-01

    Full Text Available RESUMO Objetivo: caracterizar a ansiedade dos pacientes no pré-operatório de cirurgia cardíaca. Método: Foi realizado um estudo de corte transversal no qual 106 pacientes, entre um e cinco dias da data da cirurgia, foram entrevistados utilizando-se um questionário sócio-demográfico próprio e o Inventário de Ansiedade de Beck. Resultados: Os pacientes avaliados se apresentaram em 59,4% (63 na ansiedade mínima e 19,8% (21 na faixa considerada grave, tendo a amostra uma média no nível de ansiedade leve (15,8±19,79. As mulheres tiveram escores (22,13±23,41 significativamente (p=0,003 maiores que os homens (10,76±14,71; assim como os pacientes que já haviam sido submetidos a cirurgia cardíaca prévia (24,4±28,05 X 13,14±15,74. Não houve diferença significativa entre idosos e pacientes adultos mais jovens, nem no tocante as variações de peso, presença de diabetes ou etilismo. Conclusão: Reforça-se a importância do enfermeiro reconhecer a ansiedade pré-operatória e intervir através de estratégias de educação em saúde e visita de enfermagem.

  19. Valor preditivo da frequência cardíaca em repouso do teste ergométrico na mortalidade

    Directory of Open Access Journals (Sweden)

    Jaqueline Eilert Fagundes

    2010-12-01

    Full Text Available FUNDAMENTO: A frequência cardíaca em repouso (cuja média está entre 60 e 80 bpm é uma das mais simples variáveis cardiovasculares e tem sido considerada como um preditor de mortalidade cardiovascular e geral. OBJETIVO: Avaliar o valor preditivo da frequência cardíaca em repouso (FCR, antes do teste ergométrico (TE, na mortalidade cardiovascular (CV e geral. MÉTODOS: Estudo de caso-controle, que utilizou informações contidas nos bancos de dados do laboratório de ergometria de um hospital especializado em cardiologia e os registros de óbitos da Secretaria da Saúde em uma cidade do sul do Brasil, de janeiro de 1995 a junho de 2007. Foram analisados 7.055 pacientes, sendo 1.645 (23,3% do grupo caso (óbitos e 5.410 (76,7% do grupo controle (vivos. Foi calculado o ponto de corte da FCR para mortalidade, através da curva ROC e realizada a análise multivariada para as variáveis selecionadas. Os desfechos foram mortalidade CV e geral. RESULTADOS: A incidência de mortalidade CV foi de 674 casos (9,5%; a FCR > 78 bpm foi o ponto de corte. Após ajustado para as variáveis selecionadas, o odds ratio (OR para FCR > 78 bpm foi de 3,5 (IC 95% = 2,9 - 4,2 para mortalidade CV e 3,6 (IC 95% = 3,2 - 4,0 para mortalidade geral. CONCLUSÃO: A FCR > 78 bpm é um preditor independente de mortalidade cardiovascular e geral.

  20. Acquisition of HIV-1 resistance in T lymphocytes using an ACA-specific E. coli mRNA interferase.

    Science.gov (United States)

    Chono, Hideto; Matsumoto, Kazuya; Tsuda, Hiroshi; Saito, Naoki; Lee, Karim; Kim, Sujeong; Shibata, Hiroaki; Ageyama, Naohide; Terao, Keiji; Yasutomi, Yasuhiro; Mineno, Junichi; Kim, Sunyoung; Inouye, Masayori; Kato, Ikunoshin

    2011-01-01

    Transcriptional activation of gene expression directed by the long terminal repeat (LTR) of HIV-1 requires both the transactivation response element (TAR) and Tat protein. HIV-1 mutants lacking a functional tat gene are not able to proliferate. Here we take a genetic approach to suppress HIV-1 replication based on Tat-dependent production of MazF, an ACA-specific endoribonuclease (mRNA interferase) from Escherichia coli. When induced, MazF is known to cause Bak- and NBK-dependent apoptotic cell death in mammalian cells. We first constructed a retroviral vector, in which the mazF (ACA-less) gene was inserted under the control of the HIV-1 LTR, which was then transduced into CD4+ T-lymphoid CEM-SS cells in such a way that, upon HIV-1 infection, the mazF gene is induced to destroy the infecting HIV-1 mRNA, preventing HIV-1 replication. Indeed, when the transduced cells were infected with HIV-1 IIIB, the viral replication was effectively inhibited, as HIV-1 IIIB p24 could not be detected in the culture medium. Consistently, not only cell growth but also the CD4 level was not affected by the infection. These results suggest that the HIV-1-LTR-regulated mazF gene was effectively induced upon HIV-1 IIIB infection, which is sufficient enough to destroy the viral mRNA from the infected HIV-1 IIIB to completely block viral proliferation in the cells, but not to affect normal cell growth. These results indicate that the T cells transduced with the HIV-1-LTR-regulated mazF gene acquire HIV-1 resistance, providing an intriguing potential for the use of the HIV-1-LTR-regulated mazF gene in anti-HIV gene therapy.

  1. Relação entre imagem adrenérgica cardíaca e teste ergométrico na insuficiência cardíaca Relación entre imagen adrenérgica cardíaca y ergometría en la insuficiencia cardíaca Relationship between cardiac adrenergic image and exercise testing in heart failure

    Directory of Open Access Journals (Sweden)

    Leandro Rocha Messias

    2011-05-01

    Full Text Available FUNDAMENTO: Na insuficiência cardíaca, o teste ergométrico (TE avalia capacidade funcional, um determinante de prognóstico. A cintilografia com I¹²³ MIBG mostra a ativação simpática cardíaca. OBJETIVO: Avaliar a associação entre as variáveis do TE e as alterações da cintilografia com I¹²³ MIBG. MÉTODOS: Foram submetidos 23 pacientes (FEVE 27%. Esses pacientes realizaram TE, onde foram analisadas: pressão arterial sistólica no pico do esforço (PASP, frequência cardíaca no pico do esforço (FCP, variação da pressão arterial sistólica intraesforço (Δ PAS, reserva cronotrópica e capacidade funcional em METs. Utilizaram-se para a análise estatística, o teste t de Student ou o teste U de Mann-Whitney, o coeficiente de Spearman e o coeficiente de regressão linear. RESULTADOS: A PASP (G1: 181,00 ± 28,01; G2: 153,27 ± 27,71, p = 0,027, a Δ PAS [G1: 64 (47,5-80,5; G2: 36 (25-47 mmHg, p = 0,015], a FCP (G1: 136,91 ± 19,66; G2: 118,45 ± 13,98 bpm, p = 0,018, a reserva cronotrópica (G1: 70,42 ± 17,94; G2: 49,47 ± 14,89%, p = 0,006 e a capacidade funcional [G1: 8,37 (6,47-10,27; G2: 4,42 (2,46-6,38 METs, p = 0,003] foram menores no G2. Houve correlação negativa entre taxa de Washout com PASP (r = -0,505, p = 0,014, Δ PAS (r = -0,493, p = 0,017 e capacidade funcional (r = -0,646, p = 0,001. Após regressão linear, PASP (r = -0,422, p = 0,016 e capacidade funcional (r = -0,804, p = 0,004 foram associadas com taxa de Washout. CONCLUSÃO: Em pacientes com insuficiência cardíaca, PASP e capacidade funcional foram as varáveis mais associadas com a taxa de Washout.FUNDAMENTOS: En la Insuficiencia Cardíaca, la Ergometría (Test Ergométrico - TE evalúa la capacidad funcional, un determinante de pronóstico. El centellograma con I¹²³ MIBG muestra la activación simpática cardíaca. OBJETIVO: Evaluar la asociación entre las variables del TE y las alteraciones del centellograma con I¹²³ MIBG. MÉTODOS: Se

  2. Racionalidade e métodos: estudo BREATHE - I registro brasileiro de insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    2013-05-01

    Full Text Available FUNDAMENTO: Diversos registros locais buscam de forma isolada retratar características clínicas de pacientes internados com Insuficiência Cardíaca (IC em hospitais e comunidades brasileiras. De forma geral, a análise desses dados sugere que existam diferenças importantes na etiologia, nos fatores de descompensação, no tratamento e no prognóstico de pacientes com IC nas diferentes regiões brasileiras. OBJETIVOS: Avaliar as características demográficas, clínicas, prognósticas de 1.200 pacientes admitidos com diagnóstico clínico de insuficiência cardíaca descompensada em um grupo de 60 hospitais representativos das diferentes regiões brasileiras. MÉTODOS: Estudo observacional transversal (registro com seguimento longitudinal de doze meses (visitas de admissão, alta hospitalar, três meses, seis meses e doze meses após inclusão, em que pacientes admitidos em hospitais da rede pública e privada com quadro clínico primariamente de IC definida serão estudados. RESULTADOS: Os resultados serão apresentados logo após o término da coleta, avaliação da qualidade e análise estatística dos dados. CONCLUSÕES: A análise dos resultados deste registro multicêntrico permitirá um planejamento mais adequado do aporte de recursos financeiros, pessoais e tecnológicos para a área da saúde, bem como o planejamento de medidas preventivas mais eficazes na IC descompensada.

  3. Anticorpos séricos na doença celíaca Celiac disease serum antibodies

    Directory of Open Access Journals (Sweden)

    Ceres Concilio ROMALDINI

    1999-12-01

    Full Text Available O diagnóstico acurado da doença celíaca é muito importante porque os pacientes devem aderir a uma dieta sem glúten por toda a vida e diante do maior risco de complicações, como as neoplasias intestinais, que poderá advir do não cumprimento rigoroso da dieta. Nesta revisão são apresentados os novos conceitos referentes às formas de apresentação da doença (ativa, silenciosa, latente e potencial e sua associação com outras enfermidades e são focalizados principalmente o valor e a eficácia da determinação dos anticorpos séricos antigliadina e dos autoanticorpos anti-reticulina, antiendomísio e antitransglutaminase tecidual, no auxílio ao diagnóstico e seguimento da doença celíaca.Accurate diagnosis of celiac disease is important because patients are advised to adhere to a strict gluten-free diet for life. This management is critical to avoid disease complications such as malignancies. In this review the new terminology for the disease clinical features (active, silent, latent and potential celiac disease and the disease association with other conditions are commented. The value and efficacy of the assessment of serum antigliadin antibodies and of antireticulin, antiendomysial and tissue transglutaminase autoantibodies in the diagnosis and follow-up of the celiac disease are particularly evaluated.

  4. Neuronal counting and parasympathetic dysfunction in the hearts of chronically Trypanosoma cruzi - infected rats Contagem neuronal e disfunção cardíaca parassimpática em ratos cronicamente infectados pelo Trypanosoma cruzi

    Directory of Open Access Journals (Sweden)

    E. Chapadeiro

    1991-10-01

    Full Text Available Ten male Wistar rats, chronically infected with Colombian, São Felipe (12SF and Y strains of Trypanosoma cruzi and ten non-infected control animals were submitted to the bradycardia responsiveness test, an assessment of heart parasympathetic function, after phenylephrine injection. Six chagasic animals showed heart parasympathetic dysfuntion characterized by reduction in the index of bradycardia baroreflex responsiveness, as compared with the control group. Microscopic examination of the atrial heart ganglia of chagasic rats showed ganglionitis, but no statiscally significant reduction in the number of neurons.Dez ratos machos Wistar cronicamente infectados pelas cepas Colombiana, São Felipe (12SF, e Y do Trypanosoma cruzi, foram submetidos, após 8 meses de infecção, juntamente com dez animais controles, ao teste da resposta bradicárdica barorreflexa pela injeção endovenosa de fenilefrina. Seis ratos chagásicos exibiram disfunção cardíaca parassimpática, caracterizada pela depressão do índice da resposta bradicárdica barorreflexa. Embora o estudo histológico dos corações chagásicos mostrasse lesões dos gânglios atriais, a contagem dos neurônios em cortes seriados, não apresentou redução numérica significativa dos mesmos.

  5. Despopulação neuronal cardíaca em hamsters (Mesocricetus auratus cronicamente infectados com o Trypanosoma cruzi Cardiac neuronal depopulation in hamsters (Mesocricetus auratus chronically infected with Trypanosoma cruzi

    Directory of Open Access Journals (Sweden)

    Edmundo Chapadeiro

    1999-02-01

    Full Text Available Com o objetivo de se obter um modelo experimental que permitisse estabelecer a despopulação (desnervação neuronal cardíaca procurou-se pesquisar o comportamento do sistema nervoso intracardíaco em hamsters cronicamente infectados com o T. cruzi. Para tal fim, realizaram-se contagens dos neurônios do plexo nervoso autonômico intracardíaco em hamsters inoculados com 35.000 formas sangüíneas de três cepas diferentes, sacrificados 5, 8 e 10 meses depois da infecção. Demonstrou-se, pela primeira vez, destruição neuronal significativa num modelo experimental, similar à que ocorre na doença de Chagas humana.The aim of this study was to obtain an experimental animal model of destruction of cardiac neurons in order to investigate the behavior of the cardiac nervous system of hamsters chronically infected with Trypanosoma cruzi. We counted the neuronal cells of the cardiac autonomic nervous plexus in hamsters inoculated with 35 000 blood forms of three different T. cruzi strains and killed 5, 8 and 10 months after infection. We showed for the first time severe neuronal destruction in an experimental animal model with characteristics similar to those observed in human Chagas'disease.

  6. The financial burden of medical spending: estimates and implications for evaluating the impact of ACA reforms.

    Science.gov (United States)

    Abramowitz, Joelle; O'Hara, Brett

    2015-04-01

    This article uses the 2013 Current Population Survey Annual Social and Economic Supplement to estimate the financial burden of medical out-of-pocket costs by comparing medical out-of-pocket expenditures to income. This measure is important for evaluating the magnitude of burden, better understanding who bears it, and establishing a baseline to assess the impact of the Patient Protection and Affordable Care Act. We examine the distribution of burden and the incidence of high burden across all families and by individuals' health insurance status and demographic and socioeconomic characteristics. We look more closely at one group vulnerable to having high burden: those younger than age 65 with incomes between 138% and 200% of the federal poverty line. We find that 18.5% of these individuals have incomes below the threshold of expansion Medicaid eligibility after accounting for non-over-the-counter medical expenses and examine the characteristics associated with being classified below this threshold.

  7. Miniesternotomia: um acesso seguro para a cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Leonardo Andrade MULINARI

    1997-10-01

    Full Text Available Atualmente, na constante busca de minimizar o tempo de intemação hospitalar e melhorar a recuperação no pós-operatório, várias altemativas cirúrgicas têm sido aventadas. Iniciamos o uso da estemotomia parcial como acesso para diversos tipos de operações cardíacas. O presente trabalho tem como objetivo apresentar a evolução hospitalar dos pacientes operados através desta técnica. No período de novembro de 1996 a março de 1997, estudamos 51 pacientes operados através da esternotomia parcial. A idade média foi de 46,8 anos, sendo 26 pacientes do sexo feminino. Os procedimentos mais realizados foram o tratamento cirúrgico valvar e as revascularizações miocárdicas. O acesso utilizado para os pacientes com lesões valvares foi a esternotomia parcial em "T" invertido no segmento superior do esterno; para outras lesões, uma esternotomia em "T" no segmento inferior e, pela dificuldade técnica imposta nas re-operações e nos procedimentos múltiplos, utilizou-se uma terceira variação, que foi a esternotomia parcial em "H" deitado, estendendo-se no corpo esternal do primeiro ao quarto espaço intercostal. O comprimento médio da incisão de pele foi de 9,9 cm. Foram realizadas 19 incisões em "T", 17 em "T" invertido e 15 em "H" deitado. O tempo médio de ventilação mecânica foi de 2,8 horas, de permanência na UTI de 31,5 horas e de internação hospitalar de 5,9 dias. Não houve complicação diretamente relacionada com o acesso e em apenas 1 caso foi necessária a conversão para a esternotomia total. Analisando a evolução destes 51 pacientes, pudemos concluir que a esternotomia parcial é um acesso seguro para o tratamento cirúrgico de diversas cardiopatias, isoladas, associadas ou re-operações. Traz um resultado estético favorável e facilita a recuperação no pós- operatório, devendo fazer parte do repertório de todo o cirurgião cardiovascular.Recently, in the constant search for shortening hospital stay and

  8. Determinants of dietary supplement use - healthy individuals use dietary supplements

    DEFF Research Database (Denmark)

    Kofoed, Christina L F; Christensen, Jane; Dragsted, Lars Ove

    2015-01-01

    and lifestyle between 1993 and 1997. A health index including smoking, physical activity, alcohol and diet, and a metabolic risk index including waist circumference, urinary glucose and measured hypertension were constructed. Logistic regression was used to investigate these determinants in relation...... common supplement use. In conclusion, those with the healthiest lifestyle were more likely to use dietary supplements. Thus, lifestyle and dietary composition should be considered as confounders on supplement use and health outcomes....

  9. Osmolality of preterm formulas supplemented with nonprotein energy supplements.

    Science.gov (United States)

    Pereira-da-Silva, L; Dias, M Pitta-Grós; Virella, D; Moreira, A C; Serelha, M

    2008-02-01

    Addition of energy supplements to preterm formulas is an optional strategy to increase the energy intake in infants requiring fluid restriction, in conditions like bronchopulmonary dysplasia. This strategy may lead to an undesirable increase in osmolality of feeds, the maximum recommended safe limit being 400 mOsm/kg. The aim of the study was to measure the changes in osmolality of several commercialized preterm formulas after addition of glucose polymers and medium-chain triglycerides. Osmolality was measured by the freezing point depression method. Six powdered formulas with concentrations of 14 g/100 ml and 16 g/100 ml, and five ready-to-feed liquid formulas were analyzed. All formulas, were supplemented with 10% (low supplementation) or 20% (high supplementation) of additional calories, respectively, in the form of glucose polymers and medium chain triglycerides, maintaining a 1:1 glucose:lipid calorie ratio. Inter-analysis and intra-analysis coefficients of variation of the measurements were always supplemented formulas varied between 268.5 and 315.3 mOsm/kg, increasing by 3-5% in low supplemented formulas, and by 6-10% in high supplemented formulas. None of the formulas analyzed exceeded 352.8 mOsm/kg. The supplementation of preterm formulas with nonprotein energy supplements with up to 20% additional calories did not exceed the maximum recommended osmolality for neonatal feedings.

  10. Geobacteraceae strains and methods

    Science.gov (United States)

    Lovley, Derek R.; Nevin, Kelly P.; Yi, Hana

    2015-07-07

    Embodiments of the present invention provide a method of producing genetically modified strains of electricigenic microbes that are specifically adapted for the production of electrical current in microbial fuel cells, as well as strains produced by such methods and fuel cells using such strains. In preferred embodiments, the present invention provides genetically modified strains of Geobacter sulfurreducens and methods of using such strains.

  11. Supplementing managed competition.

    Science.gov (United States)

    Higgins, W

    President Clinton's proposal for health care reform calls for managed competition within global expenditure targets. However, it is unlikely that health plans will have sufficient leverage with providers to negotiate arrangements consistent with expenditure targets in nonurban areas. This paper describes a reimbursement system based on competitive prospective payment and capitation (CPPC) which can supplement managed competition in less populous areas or replace managed competition should that strategy prove unsuccessful. The CPPC system is capable of enforcing an expenditure target while encouraging the formation of capitated networks and creating strong incentives for efficiency. It is generally compatible with the Clinton administration's version of managed competition.

  12. Zinc supplementation in burn patients.

    Science.gov (United States)

    Caldis-Coutris, Nancy; Gawaziuk, Justin P; Logsetty, Sarvesh

    2012-01-01

    Micronutrient supplementation is a common practice throughout many burn centers across North America; however, uncertainty pertaining to dose, duration, and side effects of such supplements persists. The authors prospectively collected data from 23 hospitalized patients with burn sizes ranging from 10 to 93% TBSA. Each patient received a daily multivitamin and mineral supplement, 50 mg zinc (Zn) daily, and 500 mg vitamin C twice daily. Supplements were administered orally or enterally. Albumin, prealbumin, C-reactive protein, serum Zn, and serum copper were measured weekly during hospital admission until levels were within normal reference range. Our study concluded that 50 mg daily dose of Zn resulted in normal serum levels in 19 of 23 patients at discharge; 50 mg Zn supplementation did not interfere with serum copper levels; and Zn supplements, regardless of administration route, did not result in gastrointestinal side effects.

  13. Strain and strain rate by two-dimensional speckle tracking echocardiography in a maned wolf Strain e strain rate por meio de ecocardiogratia speckle traking bidimensional em um lobo-guará

    Directory of Open Access Journals (Sweden)

    Matheus M. Mantovani

    2012-12-01

    Full Text Available The measurement of cardiovascular features of wild animals is important, as is the measurement in pets, for the assessment of myocardial function and the early detection of cardiac abnormalities, which could progress to heart failure. Speckle tracking echocardiography (2D STE is a new tool that has been used in veterinary medicine, which demonstrates several advantages, such as angle independence and the possibility to provide the early diagnosis of myocardial alterations. The aim of this study was to evaluate the left myocardial function in a maned wolf by 2D STE. Thus, the longitudinal, circumferential and radial strain and strain rate were obtained, as well as, the radial and longitudinal velocity and displacement values, from the right parasternal long axis four-chamber view, the left parasternal apical four chamber view and the parasternal short axis at the level of the papillary muscles. The results of the longitudinal variables were -13.52±7.88, -1.60±1.05, 4.34±2.52 and 3.86±3.04 for strain (%, strain rate (1/s, displacement (mm and velocity (cm/s, respectively. In addition, the radial and circumferential Strain and Strain rate were 24.39±14.23, 1.86±0.95 and -13.69±6.53, -1.01±0.48, respectively. Thus, the present study provides the first data regarding the use of this tool in maned wolves, allowing a more complete quantification of myocardial function in this species.A obtenção de parâmetros cardiovasculares em animais selvagens são importantes de serem avaliados, assim como em animais de companhia, para a obtenção da função miocárdica e determinação precoce de alterações cardíacas que poderiam evoluir para insuficiência cardíaca . A ecocardiografia speckle tracking (2D STE é uma ferramenta nova que tem sido utilizada em medicina veterinária, a qual tem demonstrado várias vantagens quanto ao seu uso, como a independência do ângulo de insonação e a possibilidade de se obter o diagnóstico precoce de altera

  14. MICROBIOLOGICAL QUALITY OF FOOD SUPPLEMENTS.

    Science.gov (United States)

    Ratajczak, Magdalena; Kubicka, Marcelina M; Kamińska, Dorota; Długaszewska, Jolanta

    2015-01-01

    Many specialists note that the food offered today - as a result of very complex technological processing - is devoid of many components that are important for the organism and the shortages have to be supplemented. The simplest for it is to consume diet supplements that provide the missing element in a concentrated form. In accordance with the applicable law, medicinal products include all substances or mixtures of substances that are attributed with properties of preventing or treating diseases with humans or animals. Permits to admit supplements to the market are issued by the Chief Sanitary Inspector and the related authorities; permits for medicines are issued by the Chief Pharmaceutical Inspector and the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products. Therefore, admittance of a supplement to the market is less costly and time consuming_than admittance of a medicine. Supplements and medicines may contain the same component but medicines will have a larger concentration than supplements. Sale of supplements at drug stores and in the form of tablets, capsules, liquids or powders makes consumer often confusing supplements with medicines. Now there are no normative documents specifying limits of microbiological impurities in diet supplements. In Polish legislation, diet supplements are subject to legal acts concerning food. Medicines have to comply with microbiological purity requirements specified in the Polish Pharmacopeia. As evidenced with the completed tests, the proportion of diet supplement samples with microbiological impurities is 6.5%. Sales of diet supplements have been growing each year, they are consumed by healthy people but also people with immunology deficiencies and by children and therefore consumers must be certain that they buy safe products.

  15. A numerical method for determining the strain rate intensity factor under plane strain conditions

    Science.gov (United States)

    Alexandrov, S.; Kuo, C.-Y.; Jeng, Y.-R.

    2016-07-01

    Using the classical model of rigid perfectly plastic solids, the strain rate intensity factor has been previously introduced as the coefficient of the leading singular term in a series expansion of the equivalent strain rate in the vicinity of maximum friction surfaces. Since then, many strain rate intensity factors have been determined by means of analytical and semi-analytical solutions. However, no attempt has been made to develop a numerical method for calculating the strain rate intensity factor. This paper presents such a method for planar flow. The method is based on the theory of characteristics. First, the strain rate intensity factor is derived in characteristic coordinates. Then, a standard numerical slip-line technique is supplemented with a procedure to calculate the strain rate intensity factor. The distribution of the strain rate intensity factor along the friction surface in compression of a layer between two parallel plates is determined. A high accuracy of this numerical solution for the strain rate intensity factor is confirmed by comparison with an analytic solution. It is shown that the distribution of the strain rate intensity factor is in general discontinuous.

  16. Sprains and Strains

    Science.gov (United States)

    ... wrestling put people at risk for strains. Gymnastics, tennis, rowing, golf, and other sports that require extensive gripping can increase the risk of hand and forearm strains. Elbow strains sometimes occur in people who participate in ...

  17. Muscle strain treatment

    Science.gov (United States)

    Treatment - muscle strain ... Question: How do you treat a muscle strain ? Answer: Rest the strained muscle and apply ice for the first few days after the injury. Anti-inflammatory medicines or acetaminophen ( ...

  18. Muscle strain (image)

    Science.gov (United States)

    A muscle strain is the stretching or tearing of muscle fibers. A muscle strain can be caused by sports, exercise, a ... something that is too heavy. Symptoms of a muscle strain include pain, tightness, swelling, tenderness, and the ...

  19. Bodybuilding supplementation and tooth decay.

    Science.gov (United States)

    Ali, M S; Batley, H; Ahmed, F

    2015-07-10

    Supplementation is a key component in bodybuilding and is increasingly being used by amateur weight lifters and enthusiasts to build their ideal bodies. Bodybuilding supplements are advertised to provide nutrients needed to help optimise muscle building but they can contain high amounts of sugar. Supplement users are consuming these products, while not being aware of their high sugar content, putting them at a higher risk of developing dental caries. It is important for dental professionals to recognise the increased risk for supplement users and to raise awareness, provide appropriate preventative advice and be knowledgeable of alternative products to help bodybuilders reach their goals, without increasing the risk of dental caries.

  20. Dietary supplements for aquatic sports.

    Science.gov (United States)

    Derave, Wim; Tipton, Kevin D

    2014-08-01

    Many athletes use dietary supplements, with use more prevalent among those competing at the highest level. Supplements are often self-prescribed, and their use is likely to be based on an inadequate understanding of the issues at stake. Supplementation with essential micronutrients may be useful when a diagnosed deficiency cannot be promptly and effectively corrected with food-based dietary solutions. When used in high doses, some supplements may do more harm than good: Iron supplementation, for example, is potentially harmful. There is good evidence from laboratory studies and some evidence from field studies to support health or performance benefits from appropriate use of a few supplements. The available evidence from studies of aquatic sports is small and is often contradictory. Evidence from elite performers is almost entirely absent, but some athletes may benefit from informed use of creatine, caffeine, and buffering agents. Poor quality assurance in some parts of the dietary supplements industry raises concerns about the safety of some products. Some do not contain the active ingredients listed on the label, and some contain toxic substances, including prescription drugs, that can cause health problems. Some supplements contain compounds that will cause an athlete to fail a doping test. Supplement quality assurance programs can reduce, but not entirely eliminate, this risk.

  1. Limiar ventilatório e variabilidade da freqüência cardíaca em adolescentes Umbral ventilatorio y variabilidad de la frecuencia cardíaca en los adolescentes Ventilatory threshold and heart rate variability in adolescents

    Directory of Open Access Journals (Sweden)

    Antônio Fernando Brunetto

    2005-02-01

    Full Text Available As análises da concentração sanguínea de lactato e das trocas gasosas respiratórias são métodos tradicionalmente empregados para identificar a transição de produção de energia pelo metabolismo muscular. No entanto, mais recentemente, vem sendo sugerido método alternativo mediante análise da variabilidade da freqüência cardíaca. Pretendeu-se, com o presente estudo, estabelecer comparações entre o limiar de variabilidade da freqüência cardíaca (LiVFC e o primeiro limiar ventilatório (LV1, em uma amostra de adolescentes. Para tanto, foram submetidos a teste de esforço físico de carga máxima em esteira ergométrica 41 sujeitos (22 rapazes e 19 moças com idades entre 15 e 18 anos. O LV1 foi identificado mediante o equivalente ventilatório de oxigênio envolvendo recursos de ergoespirometria. A variabilidade da freqüência cardíaca foi analisada por intermédio dos intervalos R-R, através da plotagem de Poincaré, que oferece informações quanto ao desvio-padrão da variabilidade instantânea batimento-a-batimento (SD1, ao desvio-padrão a longo prazo de intervalos R-R contínuos (SD2 e à razão SD1/SD2. O LiVFC foi identificado pelo SD1 de acordo com três critérios: (1 diferenças entre o SD1 de dois estágios consecutivos menor que 1ms; (2 SD1 menor que 3ms; e (3 ocorrência de ambos os critérios em conjunto. Mediante análise dos resultados verificou-se que os intervalos R-R e SD2 diminuíram progressivamente a cada intervalo de 10% do VO2pico até o final do teste de esforço físico (0,05 El análisis de la concentración sanguínea de lactato y de los cambios gaseosos respiratorios son métodos tradicionalmente empleados para identificar la transición de la producción de energía por el metabolismo muscular. No en tanto, mas recientemente viene siendo sugerido como método alternativo mediante el análisis de la variabilidad de la frecuencia cardíaca. Se pretende con el presente estudio establecer

  2. Mead production: selection and characterization assays of Saccharomyces cerevisiae strains.

    Science.gov (United States)

    Pereira, Ana Paula; Dias, Teresa; Andrade, João; Ramalhosa, Elsa; Estevinho, Letícia M

    2009-08-01

    Mead is a traditional drink, which results from the alcoholic fermentation of diluted honey carried out by yeasts. However, when it is produced in a homemade way, mead producers find several problems, namely, the lack of uniformity in the final product, delayed and arrested fermentations, and the production of "off-flavours" by the yeasts. These problems are usually associated with the inability of yeast strains to respond and adapt to unfavourable and stressful growth conditions. The main objectives of this work were to evaluate the capacity of Saccharomyces cerevisiae strains, isolated from honey of the Trás-os-Montes (Northeast Portugal), to produce mead. Five strains from honey, as well as one laboratory strain and one commercial wine strain, were evaluated in terms of their fermentation performance under ethanol, sulphur dioxide and osmotic stress. All the strains showed similar behaviour in these conditions. Two yeasts strains isolated from honey and the commercial wine strain were further tested for mead production, using two different honey (a dark and a light honey), enriched with two supplements (one commercial and one developed by the research team), as fermentation media. The results obtained in this work show that S. cerevisiae strains isolated from honey, are appropriate for mead production. However it is of extreme importance to take into account the characteristics of the honey, and supplements used in the fermentation medium formulation, in order to achieve the best results in mead production.

  3. Frequência Cardíaca de Recuperação no Primeiro Minuto no Teste de Caminhada de Seis Minutos em Pacientes com Insuficiência Cardíaca

    Directory of Open Access Journals (Sweden)

    Sabrina Lindemberg

    2014-03-01

    Full Text Available Fundamento: A frequência cardíaca de recuperação no primeiro minuto (FCR1 é um preditor de mortalidade na insuficiência cardíaca (IC, mas seu prognóstico não foi avaliado no teste de caminhada de seis minutos (TC6M nesses pacientes. Objetivo: Esse estudo teve como objetivo determinar a FCR1 no TC6M em pacientes com IC e sua correlação com a distância percorrida em seis minutos (DP6M. Métodos: Protocolo controlado, transversal, com 161 indivíduos, 126 pacientes com IC sistólica estável, divididos em dois grupos (G1 e G2, que receberam ou não β-bloqueador e 35 voluntários no grupo controle (G3 que tiveram a FCR1 registrada no TC6M. Resultados: A FCR1 e a DP6M foram significativamente diferentes nos três grupos. Os valores médios de FCR1 e DP6M foram: FCR1 = 12 ± 14 bpm G1, 18 ± 16 bpm G2 e 21 ± 13 bpm G3; DP6M = 423 ± 102 m G1, G2 396 ± 101 m e 484 ± 96 m G3 (p < 0,05. Os resultados demonstraram uma correlação entre FCR1 e DP6M no G1 (r = 0,3, p = 0,04 e G3 (r = 0,4, p = 0,03, mas não em G2 (r = 0,12, p = 0,48. Conclusão: A resposta da FCR1 foi atenuada em pacientes em uso de βB e mostrou correlação com o TC6M, refletindo uma melhor tolerância ao exercício. A FCR1 após a DP6M parece representar uma alternativa quando os testes de esforço na esteira não são tolerados.

  4. Botanical supplements: detecting the transition from ingredients to supplements

    Science.gov (United States)

    Methods were developed using flow injection mass spectrometry (FIMS) and chemometrics for the comparison of spectral similarities and differences of 3 botanical ingredients and their supplements: Echinacea purpurea aerial samples and solid and liquid supplements, E. purpurea root samples and solid s...

  5. Os arranjos configurados pela artéria celíaca no pato doméstico (Cairina moshata

    Directory of Open Access Journals (Sweden)

    Marcos Rogério Alves Pinto

    1998-01-01

    Full Text Available Mediante esta pesquisa, estudamos os arranjos configurados pela artéria celíaca em 30 patos domésticos Cairina moshata, sendo 20 machos e 10 fêmeas. Foi realizada a injeção de látex corado no sistema arterial e depois as peças foram fixadas em solução aquosa de formol a 10% para posterior dissecação dos vasos arteriais. A artéria celíaca nasce isoladamente da aorta descendente e fornece a artéria proventricular dorsal e a artéria esofágica e a seguir continua-se como tronco de dois outros ramos: esquerdo e direito. O ramo esquerdo emite um vaso que vasculariza a porção ventral do proventrículo (artéria proventricular ventral e porção terminal do esôfago e, a seguir, fornece 3 ramos que vascularizam a face lateral esquerda e a margem cranial da moela ou ventrículo, bem como a junção pilórica na sua porção cranial. Do vaso destinado à margem cranial da moela, surgem artérias ao lobo hepático esquerdo em número de 1 em 5 preparações (16,6% ± 6,8, 2 em 14 peças (46,66% ± 9,1 ou 3 em 8 peças (26,66% ± 8,1. O ramo direito envia inicialmente as artérias esplênicas cujo número foi de 2 em 6 preparações (20% ± 7,3, 3 em 12 peças (40% ± 8,9, 4 em 8 peças (26,6% ± 8,1, 5 em 3 peças (10% ± 5,5 e 6 em 1 preparação (3,33% ± 3,3. Em seguida, emite colaterais ao lobo hepático direito que foram em número de 2 em 21 preparações (70% ± 8,4 ou 3 em 9 preparações (30% ± 8,4. Ainda, o ramo direito emite artérias endereçadas ao ceco esquerdo em número de 2 em 17 preparações (56,66% ± 9,1 ou 3 em 13 casos (43,33% ± 9,1. O ramo direito origina ainda 3 vasos endereçados à face lateral direita da moela (ventrículo, à margem caudal e à junção pilórica em sua porção mais caudal. A seguir, o ramo direito da artéria celíaca continua-se como artéria pancreaticoduodenal que supre o pâncreas e as porções ascendente e descendente do duodeno.

  6. Origem das artérias celíaca e mesentérica cranial em bubalinos (Bubalus bubalis, L. 1758

    Directory of Open Access Journals (Sweden)

    Márcia Rita Fernandes Machado

    2000-01-01

    Full Text Available Com o intuito de conhecer melhor o sistema arterial nesta espécie, descrevemos a origem das artérias celíaca e mesentérica cranial dos bubalinos. Utilizamos 30 fetos e 1 animal adulto. Os fetos variavam de 4 a 8 meses de idade e tiveram seus vasos injetados com solução de látex - Neoprene, tiveram seus vasos dissecados, e um animal adulto, que teve seus vasos dissecados no local de abate. Observamos que as artérias celíaca e mesentérica cranial originavam-se da porção torácica da aorta em todos os casos, estando isoladas em 90,33% deles e em tronco comum (tronco celíaco mesentérico em 9,67% dos casos.

  7. Doença celíaca: manifestações orais na população pediátrica

    OpenAIRE

    Alamão, Stela Menezes da Costa

    2012-01-01

    Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2012 A doença celíaca é uma patologia intestinal crónica, causada pela intolerância ao glúten. É caracterizada por uma enteropatia mediada pelo sistema imunológico, associada a maioria dos nutrientes e vitaminas. Variadas são as manifestações orais encontradas nas crianças portadoras da doença celíaca, nomeadamente, defeitos do esmalte dentário, úlceras aftosas recorrentes, atraso da erupção dentár...

  8. Importância da fisioterapia no pré e pós-operatório de cirurgia cardíaca pediátrica

    OpenAIRE

    Cavenaghi,Simone; Moura,Silvia Cristina Garcia de; Silva,Thalis Henrique da; Venturinelli,Talita Daniela; Marino,Lais Helena Carvalho; Lamari,Neuseli Marino

    2009-01-01

    Complicações no pós-operatório de cirurgia cardíaca pediátrica são freqüentes, destacando-se a atelectasia e a pneumonia. A fisioterapia contribui significativamente no tratamento destas complicações. Desta forma, este estudo buscou agrupar e atualizar os conhecimentos da atuação fisioterapêutica no pré-operatório e nas complicações pulmonares do pós-operatório de cirurgia cardíaca pediátrica. Observou-se a eficácia do tratamento fisioterapêutico por meio de diferentes técnicas específicas e ...

  9. Aspectos cirúrgicos dos aneurismas isolados das artérias ilíacas Surgical aspects of isolated iliac artery aneurysms

    Directory of Open Access Journals (Sweden)

    Aquiles Tadashi Ywata de Carvalho

    2006-09-01

    Full Text Available OBJETIVO: Discorrer sobre os aspectos clínicos e o tratamento cirúrgico de uma série de casos de aneurismas isolados das artérias ilíacas. MÉTODOS: Foram analisados retrospectivamente os dados protocolados e os prontuários de 12 pacientes com diagnóstico de aneurisma isolado das artérias ilíacas, operados no Departamento de Cirurgia da Santa Casa de São Paulo, no período de novembro de 1999 a fevereiro de 2003. RESULTADOS: A freqüência do aneurisma isolado das artérias ilíacas foi de 1,5% dos aneurismas abdominais operados no período do estudo. A faixa etária variou entre 56 e 80 anos, 33% dos doentes apresentavam aneurisma bilateral, e os diâmetros dos aneurismas variaram entre 2,0 e 8,5 cm. Em 83% dos casos, os pacientes encontravam-se sintomáticos no momento do tratamento. Em nenhum dos casos o aneurisma se encontrava roto. A via de acesso utilizada nos aneurismas unilaterais foi a extraperitoneal homolateral à dilatação e, nos aneurismas bilaterais, a transperitoneal, longitudinal ou transversa. Não dissecamos o segmento posterior das artérias ilíacas para clampeamento, para evitar a ocorrência de lesão venosa intra-operatória. Não observamos mortalidade no período peroperatório. Em todos os casos, preservamos pelo menos uma artéria ilíaca interna. CONCLUSÃO: A via de acesso para os aneurismas isolados das artérias ilíacas deve ser individualizada. A preservação de pelo menos uma artéria ilíaca interna constitui uma regra a ser observada, bem como deve-se evitar a dissecção circunferencial das artérias ilíacas no intra-operatório.OBJETIVE: To discuss clinical aspects and surgical treatment of a series of cases of isolated iliac artery aneurysms. METHODS: Protocol data and medical charts of 12 patients with diagnosis of isolated iliac artery aneurysm were retrospectively analyzed. The patients underwent surgery at the Department of Surgery of Santa Casa de São Paulo, from November 1999 to

  10. ACA-Pro: calibration protocol for quantitative diffuse reflectance spectroscopy. Validation on contact and noncontact probe- and CCD-based systems

    Science.gov (United States)

    Sorgato, Veronica; Berger, Michel; Emain, Charlotte; Vever-Bizet, Christine; Dinten, Jean-Marc; Bourg-Heckly, Geneviève; Planat-Chrétien, Anne

    2016-06-01

    We have developed an adaptive calibration algorithm and protocol (ACA-Pro) that corrects from the instrumental response of various spatially resolved diffuse reflectance spectroscopy (DRSsr) systems to enable the quantification of absorption and scattering properties based on a Monte Carlo-based look-up-table approach. The protocol involves the use of a calibration reference base built with measurements of a range of different diffusive intralipid phantoms. Moreover, an advanced strategy was established to take into account the experimental variations with an additional measurement of a common solid material, allowing the use of a single calibration reference base for all experiments. The ACA-Pro is validated in contact and noncontact probe-based DRSsr systems. Furthermore, the first results of a setup replacing the probe with a CCD detector are shown to confirm the robustness of the approach.

  11. Optimización de un modelo de soporte para bioprótesis valvular cardíaca mediante métodos numéricos

    Directory of Open Access Journals (Sweden)

    Diego Marín

    2001-04-01

    Full Text Available Las bioprótesis valvulares cardíacas (BVC son sometidas a diferentes
    requerimientos mecánicos para cumplir con la actividad hemodinámica cardíaca. La experiencia demuestra que el soporte de
    la bioprótesis (ASBVC ejerce un importante papel en la operatividad
    del implante, relacionado con la distribución de tensiones en las valvas biológicas y la adecuada coaptación. Para evaluar el comportamiento del ASBVC es necesario analizar los esfuerzos y tensión necesarios para alcanzar la fatiga del dispositivo, así como calcular la concentración esfuerzo-deformación durante su funcionamiento.

  12. Fisioterapia respiratória e sua aplicabilidade no período pré-operatório de cirurgia cardíaca

    OpenAIRE

    2011-01-01

    Procedimentos cirúrgicos torácicos podem alterar a mecânica respiratória, repercutindo na função pulmonar. A presença de profissionais fisioterapeutas é fundamental no preparo e na reabilitação dos indivíduos que são submetidos à cirurgia cardíaca, visto que dispõem de um grande arsenal de técnicas. O objetivo foi verificar a efetividade de exercícios respiratórios, com e sem a utilização de dispositivos, e o treinamento muscular respiratório pré-cirurgia cardíaca na redução das complicações ...

  13. Food Components and Supplements

    DEFF Research Database (Denmark)

    Parlesak, Alexandr

    2012-01-01

    .g., secondary plant metabolites such as flavonoids), or as contaminants that enter the food chain at different stages or during the food production process. For these components, a wide spectrum of biological effects was observed that ranges from health-threatening impacts (e.g., polycyclic aromatic amines...... the growth of these bacteria (prebiotics) are added to food to achieve health effects exceeding its pure nutritional function. Several of these effects are mediated by enzyme systems involved in xenobiotic and drug metabolism, and in some cases this might lead to undesired interactions with medication...... cases, nutrients, food contaminants, and secondary plant metabolites can themselves become substrates for xenobiotic-metabolizing enzymes, resulting in health-promoting or health-threatening products. This chapter focuses on how important components of our daily nutrition and supplements can interfere...

  14. Dosagem única de troponina cardíaca T prediz risco adverso na insuficiência cardíaca descompensada Dosificación única de troponina cardíaca T predice riesgo adverso en la insuficiencia cardiaca descompensada Single cardiac troponin T measurement predicts risk for adverse outcome in decompensated heart failure

    Directory of Open Access Journals (Sweden)

    Manoel D. C. Oliveira

    2010-04-01

    Full Text Available FUNDAMENTO: O aumento discreto de troponina cardíaca no sangue de pacientes com insuficiência cardíaca (IC sugere que miofibrilas são degradadas no miocárdio e liberadas na circulação, refletindo um processo contínuo e progressivo de lesão do aparato contrátil. OBJETIVO: Correlacionar o nível sérico da troponina cardíaca-T (TnTc à admissão hospitalar de pacientes com IC descompensada e o prognóstico. MÉTODOS: Foram incluídos 79 pacientes consecutivos, internados por IC descompensada, com FEVE 2,5 mg%, insuficiência hepática ou doenças neuromusculares. RESULTADOS: Detectou-se TnTc elevada (>0,02 ng/ml em 37 pacientes (46,84%. A mortalidade global foi de 35,4%. Nos grupos TnTc elevada e TnTc baixa (FUNDAMENTO: El aumento discreto de troponina cardíaca en la sangre de pacientes con insuficiencia cardiaca (IC sugiere que miofibrillas se degraden en el miocardio y se liberen en la circulación, lo que refleja un proceso continuo y progresivo de lesión del aparato contráctil. OBJETIVO: Correlacionar el nivel sérico de la troponina cardíaca-T (TnTc al ingreso hospitalario de pacientes con IC descompensada y el pronóstico. MÉTODOS: Se incluyó a 79 pacientes consecutivos, internados por IC descompensada, con FEVI 2,5 mg%, insuficiencia hepática o enfermedades neuromusculares. RESULTADOS: Se detectó TnTc elevada (> 0,02 ng/ml en 37 pacientes (46,84%. La mortalidad global fue del 35,4%. En los grupos TnTc elevada y TnTc baja (BACKGROUND: The slight increase in cardiac troponin in the blood of patients with heart failure (HF suggests that myofibrils are degraded in the myocardium and released in the circulation, reflecting a continuous and progressive injury process in the contractile system. OBJECTIVE: To correlate the serum levels of cardiac troponin T (TnT at the hospital admission of patients with decompensated HF and prognosis. METHODS: A total of 79 consecutive patients, hospitalized due to decompensated HF, with LVEF 2

  15. Examples of Dietary Supplement Interactions

    Science.gov (United States)

    ... body.Supplement: Saw PalmettoPossible drug-supplement interaction with:Birth control pills. Can decrease effects of estrogen in the body, which can reduce the effectiveness of birth control pills.Estrogen. Can decrease estrogen levels in the body, ...

  16. Policy commercializing nonprofits in health: the history of a paradox from the 19th century to the ACA.

    Science.gov (United States)

    Fox, Daniel M

    2015-03-01

    POLICY POINTS: Health policy in the United States has, for more than a century, simultaneously and paradoxically incentivized the growth as well as the commercialization of nonprofit organizations in the health sector. This policy paradox persists during the implementation of the Affordable Care Act of 2010. For more than a century, policy in the United States has incentivized both expansion in the number and size of tax-exempt nonprofit organizations in the health sector and their commercialization. The implementation of the Affordable Care Act of 2010 (ACA) began yet another chapter in the history of this policy paradox. This article explores the origin and persistence of the paradox using what many scholars call "interpretive social science." This methodology prioritizes history and contingency over formal theory and methods in order to present coherent and plausible narratives of events and explanations for them. These narratives are grounded in documents generated by participants in particular events, as well as conversations with them, observing them in action, and analysis of pertinent secondary sources. The methodology achieves validity and reliability by gathering information from multiple sources and making disciplined judgments about its coherence and correspondence with reality. A paradox with deep historical roots persists as a result of consensus about its value for both population health and the revenue of individuals and organizations in the health sector. Participants in this consensus include leaders of governance who have disagreed about many other issues. The paradox persists because of assumptions about the burden of disease and how to address it, as well as about the effects of biomedical science that is translated into professional education, practice, and the organization of services for the prevention, diagnosis, treatment, and management of illness. The policy paradox that has incentivized the growth and commercialization of nonprofits in

  17. Recomendações da sociedade brasileira de arritmias cardíacas para serviços de holter

    Directory of Open Access Journals (Sweden)

    Adalberto Lorga Filho

    2013-08-01

    Full Text Available FUNDAMENTOS: Inúmeros indicadores são utilizados para assegurar a qualidade de um serviço; entretanto, a competência médica e o adequado fluxo de realização de um procedimento são determinantes da qualidade final. Nesse contexto, a Sociedade Brasileira de Arritmias Cardíacas pretende recomendar parâmetros mínimos necessários para garantir a excelência dos serviços de monitorização eletrocardiográfica ambulatorial. OBJETIVOS: Recomendar competências médicas mínimas e as informações necessárias para emissão do laudo de Holter. MÉTODOS: O documento foi fundamentado no conceito de medicina baseada em evidência, e nas circunstâncias em que a evidência não estava disponível a opinião de uma comissão de redação foi utilizada para a formulação da recomendação. Essa comissão foi formada por profissionais que apresentam vivência nas dificuldades do método e gestão na prestação de serviços nessa área. RESULTADOS: O profissional responsável pela análise de Holter deve conhecer as patologias cardiovasculares e ter formação consistente em eletrocardiografia, incluindo arritmias cardíacas e seus diagnósticos diferenciais. O laudo deve ser redigido de forma clara e objetiva. Os parâmetros mínimos que devem constar no laudo incluem as estatísticas do exame, assim como quantificação e análise dos distúrbios do ritmo observados durante a monitorização. CONCLUSÃO: A monitorização eletrocardiográfica ambulatorial deve ser realizada por profissionais com vivência em análise eletrocardiográfica e o laudo deve conter os parâmetros mínimos mencionados nesse documento.

  18. Avaliação eletrofisiológica cardíaca em pacientes com sarcoidose

    Directory of Open Access Journals (Sweden)

    Jefferson Curimbaba

    2011-04-01

    Full Text Available FUNDAMENTO: Sarcoidose é uma doença granulomatosa multissistêmica de origem desconhecida que pode causar morte súbita. OBJETIVO: Avaliação eletrofisiológica de pacientes com sarcoidose com suspeita de comprometimento cardíaco. MÉTODOS: Foram estudados 22 pacientes com média de idade de 55,32 ±13,13 anos, com diagnóstico de sarcoidose e suspeita de comprometimento cardíaco. Foram submetidos à avaliação clínica, exames laboratoriais, eletrocardiograma, ecocardiograma, Holter de 24h, cintilografia com gálio ou tecnécio e estudo eletrofisiológico. Em casos selecionados foi realizada tomografia por emissão de pósitrons ou ressonância magnética. Os pacientes foram seguidos ambulatoriamente com consultas trimestrais. RESULTADOS: Comprometimento cardíaco foi comprovado em quatro (18,2% pacientes. Extrassístoles ventriculares com densidade > 100/24h foram documentadas no Holter de 24h em 12 (54,5 % pacientes. O estudo eletrofisiológico revelou aumento do intervalo HV em sete (31,8% e ponto de Wenckebach aumentado em quatro (18,2% pacientes. Houve indução de fibrilação atrial em sete (31,8% e de taquicardia ventricular sustentada em um (4,5%. Nos quatro pacientes com sarcoidose cardíaca confirmada, extrassístoles ventriculares, com densidade > 100/24h foram documentadas em todos, dois apresentavam intervalo HV prolongado e fibrilação atrial foi induzida em dois. Taquicardia ventricular sustentada não foi induzida em nenhum desses pacientes. Após período médio de acompanhamento de 20,9 ± 15,7 meses, um paciente com sarcoidose cardíaca apresentou morte súbita. CONCLUSÃO: Pacientes com sarcoidose e suspeita de envolvimento cardíaco apresentam alta prevalência de EVs e distúrbios do sistema de condução.

  19. Variabilidade da frequência cardíaca em pacientes com Distrofia Miotônica tipo 1

    Directory of Open Access Journals (Sweden)

    Guilherme Fregonezi

    2012-04-01

    Full Text Available FUNDAMENTO: O envolvimento cardíaco é comum em pacientes com Distrofia Miotônica (DM. A Variabilidade da Frequência Cardíaca (VFC é uma técnica simples e confiável que pode ser útil para estudar a influência do sistema nervoso autonômico sobre o coração. OBJETIVO: Estudar a variabilidade da frequência cardíaca em pacientes com DM tipo 1. MÉTODOS: Estudamos a VFC durante registros de 5 minutos em pacientes com DM em um grupo controle saudável. Analisamos os domínios da frequência (BF e AF em unidades normalizadas (un e balanço simpático-vagal, na posição sentada e em decúbito dorsal. RESULTADOS: Dezessete pacientes (10 homens e 7 mulheres e dezessete indivíduos pareados saudáveis (10 homens e 7 mulheres foram estudados. As modulações simpática e parassimpática do coração elevadas em pacientes do sexo masculino com DM da posição em decúbito dorsal para a posição sentada em 19% da AFun e a razão BF/AF aumentaram 42,3%. Na posição sentada, os pacientes do sexo masculino com DM apresentaram balanços simpático-vagal significativamente mais elevados em 50,9% em comparação com indivíduos controles saudáveis. A VFC foi influenciada tanto pelo sexo quanto pela enfermidade apresentada. O sexo influenciou a AFun na posição em decúbito dorsal, enquanto a razão BF/AF e AFun foi afetada em ambas as posições. Análises post hoc mostraram que o sexo afeta significativamente pacientes com DM e indivíduos saudáveis de diferentes maneiras (p < 0,01. O domínio de baixa frequência na posição sentada (AFun foi significativamente influenciado pela enfermidade. CONCLUSÃO: Os resultados deste estudo sugerem que o estímulo simpático em pacientes de meia-idade do sexo masculino com DM que não está gravemente comprometido e apresenta duração moderada da doença parece ser maior do que em indivíduos saudáveis pareados.

  20. 190. Extubación en el Quirófano Como Rutina Tras Cirugía Cardíaca: 500 Casos Consecutivos

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    A. Ysasi

    2012-04-01

    Conclusiones: la extubación en el quirófano de forma rutinaria en pacientes sometidos a cirugía cardíaca es viable y segura. La necesidad de reintubación o reingreso en UCI es baja. Contribuye a la recuperación precoz del paciente y disminuye los tiempos de estancia y consumo de recursos hospitalarios.

  1. ACA透气度仪在卷烟纸机上的应用%Application of ACA porosity meter in cigarette paper machines

    Institute of Scientific and Technical Information of China (English)

    史延鹏

    2016-01-01

    介绍了ACA厂家透气度仪的组成以及系统的技术特点,控制原理及应用过程,并阐述了故障处理方法及日常维护方法。%In this essay was introduced ACA porosity meter, as well as its structure, technical characteristics, control principle and the applying process, also the fault handling and daily maintenance were elaborated.

  2. Characterization of three novel snoRNAs from Schizosaccharomyces pombe implies the structural and functional diversity of box H/ACA snoRNA family

    Institute of Scientific and Technical Information of China (English)

    QU Guosheng; ZHOU Hui; YU Chuanhe; CHEN Xiao; QU Lianghu

    2003-01-01

    Site-specific pseudouridylations of rRNAs and snRNAs are directed by small guide RNAs that usually possess conserved H and ACA motifs and the consensus secondary structure consisting of hairpin-hinge-hairpin-tail. In this study, through screening cDNA library, three novel box H/ACA snoRNAs, termed SP12, SP16 and SP20, have been identified from fisson yeast Schizosacchromyces pombe. Each of the small RNAs possesses an ACA-like motif and exhibits secondary structures containing two or three large hairpin- like domains. Although the box H is noncanonical, SP20 can be potentially folded into a typical box H/ACA snoRNA-like structure and is predicted to guide two pseudouridylations, U1208 and U1053, on 18SrRNA. In contrast, SP12 and SP16 display different structures from SP20 and have no antisense elements to rRNAs or snRNAs. Obviously, they are new members of orphan guide snoRNAs whose functions remain elusive. The genes encoded for SP12 and SP16 are both located in long intergenic regions between protein-coding genes. A post-transcriptional processing for SP16 precursor was demonstrated. Interestingly, SP20 gene is nested inside a very hypothetical ORF, but transcribed in areverse sense. Northern and RT-PCR analyses could not detect the transcript from the hypothetical ORF, and therefore exclude the expression of the spurious gene. This is the first example that a genetic locus predicted for protein-coding gene actually encodes a small non-messenger RNA in S. pombe.

  3. MicroRNAs: um novo paradigma no tratamento e diagnóstico da insuficiência cardíaca?

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    Vagner Oliveira-Carvalho

    2012-04-01

    Full Text Available MicroRNAs (miRNAs são um grupo recém-descoberto de pequenos RNAs, não codificantes, que representam uma das áreas mais estimulantes da ciência médica moderna por modularem uma enorme e complexa rede regulatória da expressão dos genes.Recentemente, linhas de evidências sugerem que os miRNAs desempenham um papel crucial na patogênese da insuficiência cardíaca. Alguns miRNAs altamente expressos no coração como o miR-1, miR-133 e miR-208 estão fortemente associados ao desenvolvimento da hipertrofia cardíaca, enquanto o exato papel de miR-21 no sistema cardiovascular permanece controverso. Os níveis séricos de miRNAs circulantes como o miR-423-5p estão sendo avaliados como potenciais biomarcadores no diagnóstico e prognóstico da insuficiência cardíaca.Por outro lado, a manipulação dos níveis de miRNAs usando técnicas como os mimetizadores de miRNAs (miRmimics e miRNAs antagônicos(antagomiRs está tornando cada vez mais evidente o enorme potencial dos miRNAs como promissoras estratégias terapêutica sna insuficiência cardíaca.

  4. Nutritional Supplements for Endurance Athletes

    Science.gov (United States)

    Rasmussen, Christopher J.

    Athletes engaged in heavy endurance training often seek additional nutritional strategies to help maximize performance. Specific nutritional supplements exist to combat certain factors that limit performance beginning with a sound everyday diet. Research has further demonstrated that safe, effective, legal supplements are in fact available for today's endurance athletes. Several of these supplements are marketed not only to aid performance but also to combat the immunosuppressive effects of intense endurance training. It is imperative for each athlete to research the legality of certain supplements for their specific sport or event. Once the legality has been established, it is often up to each individual athlete to decipher the ethics involved with ingesting nutritional supplements with the sole intent of improving performance.

  5. Efeitos do tartarato de metoprolol em pacientes portadores de insuficiência cardíaca Effects of metoprolol tartrate therapy in patients with heart failure

    Directory of Open Access Journals (Sweden)

    José Albuquerque de Figueiredo Neto

    2006-09-01

    Full Text Available OBJETIVO: Estudar os efeitos do tartarato de metoprolol em pacientes portadores de insuficiência cardíaca. MÉTODOS: Foram avaliados em estudo prospectivo, 50 pacientes (36 homens com insuficiência cardíaca, classe funcional II a IV, com 52±14,8 anos, e fração de ejeção do ventrículo esquerdo (FEVE 0,05. A freqüência cardíaca apresentou redução de 78,84±batimentos por minuto para 67,48±1,86 batimentos por minuto (pOBJECTIVE: To study the effects of metoprolol tartrate therapy in patients with heart failure. METHODS: Fifty patients (36 males aged 52±14.8 yrs, with functional class II to IV heart failure (HF and left ventricular ejection fraction (LVFE 0.05. Cardiac frequency decreased from 78.84±1.68 to 67.48±1.86 b.p.m. (p<0.001. CONCLUSION: The adding of metoprolol tartrate to the usual heart failure therapy is followed by an increase of ejection fraction, functional class improvement, and decrease of ventricular diameters and cardiac frequency. These results suggest anti-remodeling effects in patients with HF who utilize metoprolol tartrate in addition to the usual therapy.

  6. Fisher: a program for the detection of H/ACA snoRNAs using MFE secondary structure prediction and comparative genomics – assessment and update

    Science.gov (United States)

    Freyhult, Eva; Edvardsson, Sverker; Tamas, Ivica; Moulton, Vincent; Poole, Anthony M

    2008-01-01

    Background The H/ACA family of small nucleolar RNAs (snoRNAs) plays a central role in guiding the pseudouridylation of ribosomal RNA (rRNA). In an effort to systematically identify the complete set of rRNA-modifying H/ACA snoRNAs from the genome sequence of the budding yeast, Saccharomyces cerevisiae, we developed a program – Fisher – and previously presented several candidate snoRNAs based on our analysis [1]. Findings In this report, we provide a brief update of this work, which was aborted after the publication of experimentally-identified snoRNAs [2] identical to candidates we had identified bioinformatically using Fisher. Our motivation for revisiting this work is to report on the status of the candidate snoRNAs described in [1], and secondly, to report that a modified version of Fisher together with the available multiple yeast genome sequences was able to correctly identify several H/ACA snoRNAs for modification sites not identified by the snoGPS program [3]. While we are no longer developing Fisher, we briefly consider the merits of the Fisher algorithm relative to snoGPS, which may be of use for workers considering pursuing a similar search strategy for the identification of small RNAs. The modified source code for Fisher is made available as supplementary material. Conclusion Our results confirm the validity of using minimum free energy (MFE) secondary structure prediction to guide comparative genomic screening for RNA families with few sequence constraints. PMID:18710502

  7. Endovascular approach for isolated common iliac aneurysm and severe kyphoscoliosis Tratamento endovascular de aneurisma isolado de artéria ilíaca comum e cifoescoliose grave

    Directory of Open Access Journals (Sweden)

    Alexandre Campos Moraes Amato

    2009-09-01

    Full Text Available We report the case of a 72-year-old patient presenting with an isolated common iliac aneurysm with occlusion of contralateral common iliac artery and severe kyphoscoliosis. Because of high risk for open surgery due to chronic obstructive pulmonary disease, this patient was treated with an endovascular approach using an aortomonoiliac stent graft, followed by a femoro-femoral crossover bypass. This report illustrates the usefulness of a minimally invasive approach, and feasibility even for patients with difficult anatomy.Relatamos o caso de um paciente de 72 anos com aneurisma isolado de ilíaca, oclusão contralateral de artéria ilíaca comum e cifoescoliose grave. Devido ao alto risco para cirurgia convencional em razão de doença pulmonar obstrutiva crônica, o paciente foi tratado com abordagem endovascular, utilizando uma endoprótese aortomonoilíaca, seguida de uma derivação fêmoro-femoral cruzada. Este relato ilustra a utilidade de uma abordagem minimamente invasiva e demonstra que, mesmo para pacientes com anatomia difícil, é factível.

  8. Hidatidosis cardíaca primaria: quiste hidatídico en aurícula derecha con diseminación pulmonar

    Directory of Open Access Journals (Sweden)

    Christian Muñoz-Guijosa

    2009-01-01

    Full Text Available La hidatidosis es una enfermedad parasitaria producida por la larva del cestodo Echinococcus. El quiste hidatídico, la forma más habitual de presentación, es producida por la especie E. granulosus. la afectación cardíaca es muy rara, produciéndose en aproximadamente el 0,5–2% de los casos. El 65% de los casos de hidatidosis cardíaca se localizan en las cavidades izquierdas. Presentamos el caso de un paciente en el que la primera localización de la enfermedad fue la aurícula derecha (Ad, junto con diseminación pulmonar quística. La localización exclusiva en las cavidades cardíacas derechas y en la arteria pulmonar constituye una presentación clínica inusual. se ha revisado la bibliografía, prestando especial interés en la importancia de las técnicas de imagen disponibles en la actualidad para su diagnóstico, así como la necesidad de un tratamiento quirúrgico precoz para evitar sus posibles complicaciones.

  9. 76 FR 67195 - Announcing the Award of a Single-Source Program Expansion Supplement Grant to the Johns Hopkins...

    Science.gov (United States)

    2011-10-31

    ... Services (CMS) under the requirements of the Patient Protection and Affordable Care Act (ACA). To address... section 3021 of the Patient Protection and Affordable Care Act (ACA) and the Improper Payments...

  10. Dietary Supplements: What You Need to Know

    Science.gov (United States)

    ... dietary supplements? Dietary supplements include such ingredients as vitamins, minerals, herbs, amino acids, and enzymes. Dietary supplements are marketed in forms such as tablets, capsules, softgels, gelcaps, powders, and liquids. What are the ...

  11. Preparation of dodecanol-tolerant strains of Yarrowia lipolytica.

    Science.gov (United States)

    Smit, Martha S; Mokgoro, Masego M; Setati, Evodia; Nicaud, Jean-Marc

    2004-05-01

    Dodecanol (1% v/v) and dodecanoic acid (1% w/v) inhibited growth of Yarrowia lipolytica in complex media supplemented with glucose but dodecanedioic acid (1% w/v) was not toxic. Dodecanol-tolerant strains were prepared from the wild type strain H222 as well as the acyl-CoA oxidase deleted (deltaPOX2, POX3, POX5) strain MTLY35. These strains grew in rich media containing up to 10% (v/v) dodecanol. Dodecanol-tolerant strains remained dodecanol tolerant after they had been cultured in rich media without dodecanol. No significant amount of dodecanedioic acid was accumulated by the dodecanol-tolerant strains when grown on glucose in the presence of dodecanol.

  12. Intervención psicológica en cirugía cardíaca

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    Yalilis Castillero Amador

    2007-01-01

    Full Text Available La cirugía mayor y en particular la cirugía cardiovascularson una fuente potencial de estrés. Este artículo muestra la efectividad de la preparación psicológica en los pacientes sometidos a cirugía cardíaca. A través de una revisión de la literatura consideramos el impacto, tanto físico como psicológico, que tiene el padecer una enfermedad cardiovascular y el ser sometido a una cirugía del corazón.El corazón es un órgano al que se le atribuye un carácter de primacía en relación con los otros, por lo que existe un gran número de respuestas emocionalesante cualquier padecimiento relacionado con el mismo. Se puntualizan los beneficios de la intervenciónpsicológica en la cirugía y se propone un programa que facilite un adecuado afrontamiento y recuperación en la cirugía cardiovascular.

  13. Fatores associados ao padrão de sono em pacientes com insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Mariana Alvina dos Santos

    2011-10-01

    Full Text Available O estudo teve como objetivo descrever o padrão de sono em pacientes com insuficiência cardíaca (IC e analisar associações do sono com as seguintes variáveis: sexo, idade, fadiga, fadiga ao esforço, atividade física, classe funcional, terapia medicamentosa, dispneia e índice de massa corporal. A amostra não probabilística foi de 400 pacientes (idade média 57,8 anos; 64,8% eram homens; escolaridade média de 6,1 anos; 82,5% em classe funcional II ou III. A prevalência de maus dormidores foi de 68,5% e 46,5% classificou o sono como ruim ou muito ruim. Escores que sugerem categoria de mau dormidor foram associados a: sexo feminino, não empregados, fadiga, fadiga ao esforço, dispneia e classes funcionais mais elevadas da IC. A proporção de maus dormidores entre os pacientes com IC está entre as mais altas nas doenças crônicas. Dispneia e fadiga, sintomas comuns a essa enfermidade, aumentam significativamente a chance de ser mau dormidor.

  14. A implantação da consulta de enfermagem ao paciente com insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Ana Carla Dantas Cavalcanti

    2009-03-01

    Full Text Available Trata-se de relato de experiência do Projeto de Extensão “Consulta de Enfermagem ao Paciente comInsuficiência Cardíaca” (IC, desenvolvido com o apoio do Curso de Mestrado em Ciências Cardiovasculares e doNúcleo de Fundamentos de Enfermagem da Universidade Federal Fluminense(RJ. Tem como objetivo descreversua implementação enquanto modalidade adequada e eficaz, para proporcionar ensino, pesquisa e assistência.O projeto é constituído das seguintes atividades: consulta de enfermagem baseada em NANDA-NIC-NOC(NNN;triagem, educação em saúde na sala de espera, desenvolvidas por docentes, enfermeiros e acadêmicos deenfermagem. O processo de cuidar permeia a identificação e compreensão das respostas dos pacientes cominsuficiência cardíaca aos problemas de saúde reais e potenciais facilitando a escolha de intervenções deenfermagem. Assim, estimula medidas farmacológicas e não-farmacológicas que se propõem a melhorar aqualidade de vida e aderência ao tratamento através de educação em saúde.

  15. MAPEAMENTO DOS CUIDADOS DE ENFERMAGEM PARA PACIENTES EM PÓS-OPERATÓRIO DE CIRURGIA CARDÍACA

    Directory of Open Access Journals (Sweden)

    Ana Luisa Brandão de Carvalho Lira

    2012-01-01

    Full Text Available Estudio descriptivo con enfoque cuantitativo, con objetivo de identificar la atención proporcionada por enfermeros en unidades de cuidados intensivos a los pacientes en postoperatorio cardíaco y compararlos con lo que se evidencia en la literatura. El estudio se realizó en hospital universitario del Brasil, de enero a febrero de 2012. Seis enfermeros completaron el cuestionario con preguntas acerca de datos sociodemográficos y la atención prestada a los pacientes sometidos a cirugía cardíaca. La atención de enfermería identificada fue agrupado en siete categorías: mantenimiento del gasto cardíaco, de la integridad de los tejidos, del equilibrio de electrolitos, de la ventilación y oxigenación, prevención y tratamiento del dolor, prevención y control de la infección, y apoyo psicológico. Las acciones de enfermería identificadas en este estudio están de acuerdo con las diversas prácticas recomendables por la literatura.

  16. Estressores percebidos por pacientes no pós-operatório imediato de cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Carina Aparecida Marosti Dessotte

    2016-08-01

    Full Text Available RESUMO Objetivo: investigar os estressores percebidos pelos pacientes no pós-operatório imediato de cirurgia cardíaca e sua relação com características sociodemográficas e clínicas. Método: estudo correlacional, prospectivo, desenvolvido no interior paulista, entre agosto/2013 e dezembro/2014. Uma amostra não probabilística foi constituída por pacientes submetidos à primeira cirurgia de revascularização do miocárdio e/ou correção de valvulopatias. Utilizamos a "Escala de Avaliação de Estressores em Unidade de Terapia Intensiva". Resultados: participaram 105 pacientes. O item avaliado como mais estressante foi "ter sede", e o menos estressante foi "membro da equipe de enfermagem não se apresentar pelo nome". Das variáveis sociodemográficas e clínicas investigadas (sexo, idade, tipo e tempo de cirurgia, dor, tempo de entubação, uso de psicotrópico e tempo na unidade de terapia intensiva, apenas dor apresentou relação significativa com os estressores. Conclusão: conhecer os estressores pode auxiliar na implementação de práticas relacionadas à sua redução, favorecendo a recuperação dos pacientes.

  17. Bloqueo y radiofrecuencia de la articulación sacroilíaca Block and radiofrequency sacroiliac joint

    Directory of Open Access Journals (Sweden)

    J. De Andrés Ares

    2012-12-01

    Full Text Available La articulación sacroilíaca (ASI es una importante fuente de dolor axial, contribuyendo en hasta un 15% del dolor crónico axial. Existen numerosas pruebas diagnósticas, aunque el examen físico, las pruebas radiológicas son insuficientes para el adecuado diagnóstico. El criterio diagnóstico más aceptado es el alivio del dolor de la ASI tras uno o varios bloqueos diagnósticos intra-articulares con anestésicos locales, realizados de manera adecuada. El proceder ante la positividad del bloqueo es la radiofrecuencia de las ramas que inervan la ASI. En el siguiente artículo se repasará la anatomía, el diagnóstico y los distintos tratamientos intervencionistas del dolor de origen sacroilíaco.Sacroiliac joint (ASI is an important source of pain, contributing to 15% of chronic back pain. There are numerous diagnostic tests, although historical and physical examination findings and radiological imaging are insufficient for a proper diagnosis. An analgesic response to a properly performed diagnostic block, is the most reliable method to diagnose sacroiliac joint pain. If there is a positive block, radiofrequency denervation of the ASI is performed for a longterm pain-free period. The following article will review the anatomy, diagnosis and interventional treatment of sacroiliac joint pain.

  18. Insuficiência cardíaca: expressões do conhecimento das pessoas sobre a doença

    Directory of Open Access Journals (Sweden)

    Maria Teresa Silva de Freitas

    2013-08-01

    Full Text Available Pesquisa de natureza qualitativa que teve como objetivos caracterizar pessoas com Insuficiência Cardíaca (IC segundo perfil sócio-demográfico, de saúde e de tratamento e analisar o conhecimento sobre a doença e tratamento. Foram entrevistados 42 pacientes com IC, em um hospital de cardiologia de São Paulo, foi utilizado questionário semiestruturado e análise de conteúdo dos dados. Predominou sexo masculino, idade maior que 45 anos, classe funcional II, comorbidades associadas e tratamento farmacológico. Da análise de conteúdo emergiram as categorias: conhecimento sobre a doença e conhecimento do tratamento. O conhecimento é ilustrativo, diagnóstico e explicativo, sendo atribuídos muitos significados à doença. A maioria desconhece nome, dose e frequência de uso dos medicamentos. O tratamento não farmacológico está relacionado às orientações dos profissionais de saúde sobre alimentação, sal e ingesta hídrica. Os resultados abrem perspectivas para intervenções educativas sistematizadas que possam contribuir para um melhor enfrentamento e manejo da doença.

  19. Effects of supplementation with L. plantarum TN8 encapsulated in alginate-chitosan in broiler chickens.

    Science.gov (United States)

    Trabelsi, Imen; Ktari, Naourez; Ben Slima, Sirine; Bouchaala, Kamel; Ben Salah, Riadh

    2016-08-01

    This study was undertaken to investigate the effects of supplementation of probiotic strain Lactobacillus plantarum TN8 encapsulated in sodium alginate-chitosan or a commercial blend of essential oils on total cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and growth performance of broiler chickens. The results showed that the broiler chickens supplemented with encapsulated L. plantarum TN8 or essential oil has a higher growth than the control group. After 35days, the weight means were 1860 and 1880g respectively in dietary supplementation with probiotic or essential oil, while they are 1800g in the control group. The evolution of the feed consumption and feed conversion per week showed that the supplementation of encapsulated TN8 strain or essential oil in broiler chickens food has a positive influence on their appetite. Similarly, supplementation of the feed with this encapsulated strain significantly reduced the rate of cholesterol (HDL and LDL) as well as the contents of triglycerides in broiler chickens. Through our study, it appears that the use of the probiotic supplementation or essential oil to broilers were found to be better than the control group of chickens, resulting in a significant economic impact and promoting effect on health. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Relação entre o Paratormônio e Depressão na insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Hakan Altay

    2012-10-01

    Full Text Available FUNDAMENTO: Tem-se observado que a depressão é preditora de reinternação e mortalidade na insuficiência cardíaca. O hormônio da paratireoide é um biomarcador novo e promissor que pode predizer a internação, a capacidade funcional e a mortalidade na insuficiência cardíaca. OBJETIVO: Nosso objetivo foi investigar a associação da depressão aos níveis séricos de hormônio da paratireoide em pacientes com insuficiência cardíaca sistólica. MÉTODOS: Cem pacientes ambulatoriais consecutivos com IC sistólica com fração de ejeção do ventrículo esquerdo 18. Esses pacientes apresentavam níveis de hormônio da paratireoide significativamente mais elevados em comparação com aqueles com bons escores de BDI (133 ± 46 pg/ml versus 71 ± 26 pg/ml, p < 0,001. No modelo de regressão logística multivariada, constatou-se que o nível do hormônio da tireoide (razão de chances (OR = 1.035, p = 0,003, fração de ejeção do ventrículo esquerdo (OR = 0,854, p = 0,004, classe funcional III / IV (OR = 28,022, p = 0,005, C-reactive protein (CRP (OR = 1,088, p = 0,020 e presença de edema pré-tibial (OR = 12,341, p = 0,033 constituíam preditores independentes de depressão moderada a importante após o ajuste de outros possíveis fatores de confusão. CONCLUSÃO: Pacientes com insuficiência cardíaca sistólica com depressão moderada a importante apresentavam níveis séricos elevados de hormônio da tireoide e CRP, capacidade funcional ruim e fração de ejeção do ventrículo esquerdo mais baixa. A associação da depressão com esses parâmetros pode explicar a contribuição da depressão para a internação e a mortalidade na insuficiência cardíaca.

  1. Perfil clínico y funcional de los pacientes con insuficiencia cardíaca sistólica y disfunción renal

    Directory of Open Access Journals (Sweden)

    ADRIANA ACOSTA

    2009-01-01

    Full Text Available RESUMENIntroducciónLa disfunción renal está fuertemente asociada con la insuficiencia cardíaca crónica. Es unacomplicación habitual y progresiva de esta condición, con una evolución clínica que fluctúacon la clase funcional y el tratamiento farmacológico.ObjetivosDefinir la prevalencia y el perfil clínico y funcional de pacientes con disfunción renal en elcontexto de insuficiencia cardíaca con baja fracción de eyección.Material y métodosEn 132 pacientes con insuficiencia cardíaca y fracción de eyección < 40% se midió la depuración de creatinina. Se definió disfunción renal a una depuración de creatinina < 60 ml/min. Se realizaron analítica sanguínea, ecocardiograma, bioimpedanciometría y caminatade 6 minutos.ResultadosLa prevalencia de disfunción renal fue del 43,2% (57 pacientes. Comparados con el resto,en estos pacientes hubo mayor prevalencia de sexo femenino, mayor edad y menos frecuentementeetiología coronaria. En el laboratorio tuvieron valores menores de hemoglobina,albúmina, ferritina y triyodotironina y mayor prevalencia de troponina T dosable. Fueronmenores el índice de masa corporal (IMC, la tasa metabólica basal, la masa muscular y elángulo de fase, mientras que la relación agua extracelular/agua corporal total fue mayor. Ladistancia recorrida en la prueba de 6 minutos fue menor. Respecto del tratamiento, sólodifirió el uso de betabloqueantes y amiodarona. En el análisis multivariado, la edad, el nivelde NT-proBNP, la presencia de troponina T positiva y la masa muscular como variable continuafueron predictores independientes de disfunción renal en pacientes con insuficienciacardíaca sistólica.ConclusionesLa disfunción renal es frecuente en pacientes con insuficiencia cardíaca con baja fracciónde eyección y se vincula con características distintivas que pueden contribuir a explicar elcuadro clínico.REV ARGENT CARDIOL 2009;77:286-292.

  2. Polimorfismo G894T da óxido nítrico-sintetase endotelial e o prognóstico na insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Oziel Marcio Araujo Tardin

    2013-10-01

    Full Text Available FUNDAMENTO: Estudos prévios avaliaram o papel do polimorfismo genético da enzima óxido nítrico-sintetase endotelial sobre o prognóstico na insuficiência cardíaca. Entretanto, faltam estudos relacionando o G894T e a insuficiência cardíaca na população brasileira. OBJETIVO: Avaliar a associação do G894T com o prognóstico de amostra de pacientes brasileiros com insuficiência cardíaca. MÉTODOS: Coorte com 145 pacientes com insuficiência cardíaca sistólica, num segmento de 40 meses (média = 22 meses, em dois hospitais universitários do Estado do Rio de Janeiro. Foi avaliada a relação do G894T com os desfechos: remodelamento reverso; melhora da classe funcional (NYHA; taxas de mortalidade e hospitalização. Os diâmetros do átrio e ventrículo esquerdos e a fração de ejeção do ventrículo esquerdo foram medidos na admissão e após 6 meses, para avaliação do remodelamento reverso. A melhora na classe funcional foi avaliada após 6 meses e as taxas de mortalidade e de hospitalização durante todo o seguimento. A raça foi autodeclarada. O polimorfismo G894T foi analisado por reação em cadeia de polimerase e por análise do polimorfismo dos fragmentos de restrição. RESULTADOS: A frequência genotípica foi GG (40%, GT (48,3% e TT (11,7%, e a frequência alélica foi guanina (64,1% e tiamina (35,8%. Não houve diferença entre as frequências genotípica ou alélica conforme a raça autodeclarada, tampouco conforme as características basais. Não houve relação entre o genótipo ou a frequência alélica e os desfechos analisados. CONCLUSÃO: Não se observou associação do polimorfismo G894T (Glu298Asp com o prognóstico de amostra de pacientes ambulatoriais brasileiros com insuficiência cardíaca sistólica.

  3. Exercício físico e microRNAs: novas fronteiras na insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Miguel Morita Fernandes-Silva

    2012-05-01

    Full Text Available Embora recentemente tenha sido questionado o impacto do exercício na sobrevida de pacientes com insuficiência cardíaca, o treinamento físico melhora a qualidade de vida, a capacidade funcional, a inflamação, a função autonômica e a função endotelial. Nos últimos anos, vem crescendo o interesse em um grupo de pequenos RNAs não codificadores de proteína chamados microRNAs. Estudos têm demonstrado que a expressão dessas moléculas se modifica em diversas condições patológicas, como a hipertrofia miocárdica, a isquemia miocárdica e a insuficiência cardíaca, e, quando ocorre melhora clínica, elas parecem se normalizar. Com o potencial de aplicabilidade prática, já foram identificados marcadores que poderão ser úteis na avaliação diagnóstica e prognóstica da insuficiência cardíaca, como o miR-423-5p. Além disso, resultados de estudos experimentais indicam haver possíveis efeitos terapêuticos dos microRNAs. Implicados na regulação da expressão genética durante o desenvolvimento fetal e no indivíduo adulto, os microRNAs aumentam ou diminuem no coração em resposta a estresse fisiológico, injúria ou sobrecarga hemodinâmica. Assim, o estudo do comportamento dessas moléculas no exercício físico vem trazendo informações importantes quanto aos efeitos dessa modalidade terapêutica e representa uma nova era no entendimento da insuficiência cardíaca. Esta revisão tem por objetivo integrar as evidências sobre microRNAs na insuficiência cardíaca com maior relevância no estudo do exercício físico.

  4. China's Developing Dietary Supplement Industry

    Institute of Scientific and Technical Information of China (English)

    Jeff Crowther

    2011-01-01

    @@ With the increasingly large size and forward momentum of China's economy, one would think there has to be a well-developed dietary supplement industry.However, although China has been posting re-cord gains to its GDP, it is far behind the U.S., E.U.and Japan in regard to a well-defined and prosperous dietary supplement industry.With that said, having an established dietary supple-ment industry is not the measure by which countries are judged in terms of economic prowess.

  5. Dietary supplements in sport nutrition

    OpenAIRE

    BOČAN, David

    2015-01-01

    Thesis deals with dietary supplements and their use by amateurs and professionals.The theoretical part is in the 1st part devoted to supplements and their legislation,forms and division.To the 2nd part was selected substances used by athletes and further discussed in terms of their function and effects on the organism.Within the general information was drafted in the 3rd part risks related to the use of dietary supplements due to wrong dosage or concentration and the issue of doping. Research...

  6. Zinc supplementation for tinnitus.

    Science.gov (United States)

    Person, Osmar C; Puga, Maria Es; da Silva, Edina Mk; Torloni, Maria R

    2016-11-23

    Tinnitus is the perception of sound without external acoustic stimuli. Patients with severe tinnitus may have physical and psychological complaints and their tinnitus can cause deterioration in their quality of life. At present no specific therapy for tinnitus has been found to be satisfactory in all patients. In recent decades, a number of reports have suggested that oral zinc supplementation may be effective in the management of tinnitus. Since zinc has a role in cochlear physiology and in the synapses of the auditory system, there is a plausible mechanism of action for this treatment. To evaluate the effectiveness and safety of oral zinc supplementation in the management of patients with tinnitus. The Cochrane ENT Information Specialist searched the ENT Trials Register; Central Register of Controlled Trials (CENTRAL 2016, Issue 6); PubMed; EMBASE; CINAHL; Web of Science; ClinicalTrials.gov; ICTRP and additional sources for published and unpublished trials. The date of the search was 14 July 2016. Randomised controlled trials comparing zinc supplementation versus placebo in adults (18 years and over) with tinnitus. We used the standard methodological procedures recommended by Cochrane. Our primary outcome measures were improvement in tinnitus severity and disability, measured by a validated tinnitus-specific questionnaire, and adverse effects. Secondary outcomes were quality of life, change in socioeconomic impact associated with work, change in anxiety and depression disorders, change in psychoacoustic parameters, change in tinnitus loudness, change in overall severity of tinnitus and change in thresholds on pure tone audiometry. We used GRADE to assess the quality of the evidence for each outcome; this is indicated in italics. We included three trials involving a total of 209 participants. The studies were at moderate to high risk of bias. All included studies had differences in participant selection criteria, length of follow-up and outcome measurement

  7. Effect of olive mill waste (OMW) supplementation to Oyster mushrooms substrates on the cultivation parameters and fruiting bodies quality

    NARCIS (Netherlands)

    Ruiz-Rodriguez, A.; Soler-Rivas, C.; Polonia, I.; Wichers, H.J.

    2010-01-01

    Seven Oyster mushroom strains were cultivated in wheat straw (WS) bags supplemented with 0 up to 90% olive mill waste (OMW), a solid residue obtained from a two-phases olive oil production system. All mushroom strains could grow but high OMW concentrations resulted in a significant yield, biological

  8. Detection of changes in the cellular composition of Salmonella enterica serovar Typhimurium in the presence of antimicrobial compound(s) of Lactobacillus strains using Fourier transform infrared spectroscopy.

    Science.gov (United States)

    Zoumpopoulou, Georgia; Papadimitriou, Konstantinos; Polissiou, Moschos G; Tarantilis, Petros A; Tsakalidou, Effie

    2010-11-15

    It was previously established that Lactobacillus fermentum ACA-DC 179, Lactobacillus plantarum ACA-DC 287 and Lactobacillus plantarum ACA-DC 2350 exhibit antimicrobial activity against Salmonella enterica serovar Typhimurium. In order to further investigate the killing effect of these microorganisms against Salmonella cells, we employed Fourier transform infrared spectroscopy (FT-IR). Salmonella cells were incubated with different concentrated lactobacilli supernatants and their FT-IR spectra were recorded. The second derivative transformation of the original spectra revealed changes in spectral regions corresponding to absorptions of major cellular constituents (e.g. cell wall, cell membrane, and proteins of the cell) among the Salmonella cells treated with the supernatants and those treated with the control samples. Principal component analysis of the second derivative transformed spectra showed that the yet unidentified antimicrobial compound(s) produced by the lactobacilli tested clearly interfered with the fatty acids of the cell membrane, as well as the polysaccharides of the cell wall in Salmonella cells, pointing towards a dual killing mode. Our study shed light for the first time in the anti-Salmonella activity of the particular Lactobacillus strains.

  9. Determinaci?n de la prevalencia de los principales factores de riesgo cardiovascular en pacientes con insuficiencia card?aca hospitalizados en el servicio de medicina interna del Hospital Enrique Garc?s de la ciudad de Quito en el per?odo comprendido desde enero hasta diciembre del 2013

    OpenAIRE

    Mascote M?rquez, Jos? Eduardo

    2015-01-01

    Contexto: La insuficiencia card?aca afecta aproximadamente a 23 millones de personas en el mundo. El patr?n de factores de riesgo para insuficiencia card?aca suele ser diferente entre los pa?ses. Objetivo: Determinar la prevalencia de los principales factores de riesgo cardiovascular en pacientes con insuficiencia card?aca hospitalizados en el Servicio de Medicina Interna del Hospital Enrique Garc?s. Dise?o: Estudio transversal de prevalencia. Lugar y sujetos: Pacientes con diagn?sti...

  10. To supplement or not to supplement: a metabolic network framework for human nutritional supplements.

    Directory of Open Access Journals (Sweden)

    Christopher D Nogiec

    Full Text Available Flux balance analysis and constraint based modeling have been successfully used in the past to elucidate the metabolism of single cellular organisms. However, limited work has been done with multicellular organisms and even less with humans. The focus of this paper is to present a novel use of this technique by investigating human nutrition, a challenging field of study. Specifically, we present a steady state constraint based model of skeletal muscle tissue to investigate amino acid supplementation's effect on protein synthesis. We implement several in silico supplementation strategies to study whether amino acid supplementation might be beneficial for increasing muscle contractile protein synthesis. Concurrent with published data on amino acid supplementation's effect on protein synthesis in a post resistance exercise state, our results suggest that increasing bioavailability of methionine, arginine, and the branched-chain amino acids can increase the flux of contractile protein synthesis. The study also suggests that a common commercial supplement, glutamine, is not an effective supplement in the context of increasing protein synthesis and thus, muscle mass. Similar to any study in a model organism, the computational modeling of this research has some limitations. Thus, this paper introduces the prospect of using systems biology as a framework to formally investigate how supplementation and nutrition can affect human metabolism and physiology.

  11. Perfil de saúde de pacientes acometidos por insuficiência cardíaca Perfil de la salud de los pacientes que sufren de insuficiencia cardíaca Health profile of patients suffering from heart failure

    Directory of Open Access Journals (Sweden)

    Guilherme Abner Sousa Almeida

    2013-06-01

    Full Text Available O estudo objetivou caracterizar os clientes com diagnóstico de Insuficiência Cardíaca (IC, segundo o modelo de Campo de Saúde, identificando fatores de risco. O estudo, com abordagem quantitativa, foi realizado por meio de entrevista com 37 pacientes com diagnóstico médico de IC; utilizou-se questionário semiestruturado baseado no modelo de "Campo de Saúde". A média de idade dos pacientes foi de 60±15 anos, com predominância do sexo feminino (59,5% e da hipertensão arterial (75,7%. O consumo de bebidas alcoólicas e o tabagismo são praticados por, respectivamente, 13,5% e 21,6% dos pacientes. Os doces e refrigerantes são consumidos diariamente por 21,6% dos pacientes. O diagnóstico de IC é desconhecido por 75,7% dos pacientes e 40,5% procuram os serviços de saúde apenas em casos de urgência. Os determinantes da saúde que compõem o Campo de Saúde indicaram um meio propício para o surgimento da IC, prejudicando a qualidade de vida da população.Estudio que objetivó describir los clientes con un diagnóstico de Insuficiencia Cardíaca (IC, de acuerdo con el modelo de Campo de Salud, identificando factores de riesgo. Este es un estudio cuantitativo, realizado a través de entrevistas con 37 pacientes con diagnóstico de IC, utilizando cuestionario semiestructurado con base en el modelo de "Campo de Salud". La edad media de los pacientes fue de 60 ± 15 años, con predominancia del sexo femenino (59,5% y mayoría con hipertensión arterial (75,7%. El consumo de bebidas alcohólicas y el tabaquismo se llevan, respectivamente, un 13,5% y 21,6% de los pacientes. Los dulces y refrescos que se consumen a diario, en un 21,6% de los pacientes. El diagnóstico de IC es desconocido (75,7% y el 40,5% de los pacientes buscan servicios de salud sólo en situaciones de emergencia. Los determinantes de la salud que componen el Campo de Salud indicaron un medio favorable para la aparición de la IC, trayendo perjuicio para la calidad de

  12. Stress factors for patients undergoing cardiac surgery Factores estresantes para el paciente sometido a cirugía cardíaca Fatores estressantes para o paciente submetido a cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Cristiane Franca Lisboa Gois

    2012-08-01

    Full Text Available Objective. To describe the stress factors related to cardiac surgery and to the environment in an Intensive Care Unit (ICU. Methodology. Exploratory, descriptive and qualitative study based on the statements of patients undergoing cardiac surgery. The data was collected through semi-structured interviews and reviewed using thematic content analysis. Results. Four categories emerged: 1 Surgical experience: overcoming fear; 2 the ICU environment and the postoperative period: a difficult experience; 3 unpleasant experiences: thirst, intubation and pain; and 4 relationship with health care professionals: impersonality, professional presence representing safety and comfort, orientation and information representing safety and clarification. Conclusion. Two groups of stress factors were identified: the intra personal (thirst, pain and others and extra personal related to the environment.Objetivo. Describir los factores estresantes relacionados con la cirugía cardiaca y al ambiente en una unidad de cuidados intensivos (UCI. Metodología. Estudio exploratorio, descriptivo, cualitativo de las narrativas de pacientes sometidos a cirugía cardiaca. Mediante entrevistas semiestructuradas se recolectaron los datos y se revisó el contenido por análisis temático. Resultados. Emergieron cuatro categorías: 1 experiencia quirúrgica: el miedo como algo ya superado; 2 el ambiente de la UCI y el postoperatorio: experiencia difícil; 3 experiencias desagradables: sed, entubación y dolor; y 4 relaciones con profesionales de salud: impersonalidad, presencia profesional que significa seguridad y confort, orientación y formación significado de seguridad y mayores informaciones. Conclusión. Fueron identificados dos grupos de factores estresantes: los intrapersonales (sed, dolor, entre otros y extra-personales, relacionados con el ambiente.Objetivo. Descrever os fatores estressantes relacionados a cirurgia cardíaca e ao ambiente numa unidade de tratamentos

  13. Anemia nos pacientes com insuficiência cardíaca avançada Anemia en los pacientes con insuficiencia cardíaca avanzada Anemia in patients with advanced heart failure

    Directory of Open Access Journals (Sweden)

    Juliano Cardoso

    2010-10-01

    Full Text Available FUNDAMENTO: Anemia está associada à pior evolução nos pacientes com insuficiência cardíaca (IC. Entretanto, há poucos estudos sobre a anemia nos pacientes com IC avançada. OBJETIVO: Avaliar as características da anemia na IC em fase avançada. MÉTODOS: Foram incluídos 99 pacientes hospitalizados para compensação de IC (CF IV/NYHA, com idade > 18 anos e FEVE 12 g/dl. A anemia foi marcador independente de mau prognóstico na análise multivariada (mortalidade 47% vs 24,6%, p = 0,016, risco relativo 2,54. CONCLUSÃO: Anemia acomete, aproximadamente, 1/3 dos pacientes com IC avançada, e a deficiência de ferro é uma importante etiologia. Pacientes anêmicos são mais idosos e apresentaram função renal mais deteriorada. A melhora da congestão não foi suficiente para melhorar a anemia na maioria dos casos. Nos pacientes com IC avançada, a anemia é marcador independente de mau prognóstico.FUNDAMENTO: Anemia está asociada a peor evolución en los pacientes con insuficiencia cardíaca (IC. Mientras tanto, hay pocos estudios sobre la anemia en los pacientes con IC avanzada. OBJETIVO: Evaluar las características de la anemia en la IC en fase avanzada. MÉTODOS: Fueron incluidos 99 pacientes hospitalizados para compensación de IC (CF IV/NYHA, con edad > 18 años y FEVI 12 g/dl. La anemia fue marcador independiente de mal pronóstico en el análisis multivariado (mortalidad 47% vs 24,6%, p = 0,016, riesgo relativo 2,54. CONCLUSIÓN: Anemia afecta, aproximadamente, 1/3 de los pacientes con IC avanzada, y la deficiencia de hierro es una importante etiología. Pacientes anémicos son más añosos y presentaron función renal más deteriorada. La mejora de la congestión no fue suficiente para mejorar la anemia en la mayoría de los casos. En los pacientes con IC avanzada, la anemia es marcador independiente de mal pronóstico.BACKGROUND: Anemia is linked with worsening of progress in patients with heart failure (HF. However, there are

  14. Sensibilidade do eletrocardiograma na hipertrofia ventricular de acordo com gênero e massa cardíaca Electrocardiogram sensitivity in left ventricular hypertrophy according to gender and cardiac mass

    Directory of Open Access Journals (Sweden)

    Ana P. Colossimo

    2011-09-01

    Full Text Available FUNDAMENTO: Sabe-se que vários fatores interferem na sensibilidade do Eletrocardiograma (ECG no diagnóstico da Hipertrofia Ventricular Esquerda (HVE, sendo o gênero e a massa cardíaca alguns dos principais. OBJETIVO: Avaliar a influência do sexo na sensibilidade de alguns dos critérios utilizados para a detecção de HVE, de acordo com a progressão do grau de hipertrofia ventricular. MÉTODOS: De acordo com o gênero e com o grau de HVE ao ecocardiograma, os pacientes foram divididos em três grupos: HVE leve, moderada e severa. Avaliou-se a sensibilidade do ECG para detectar HVE entre homens e mulheres, conforme o grau de HVE. RESULTADOS: Dos 874 pacientes, 265 eram homens (30,3% e 609, mulheres (69,7%. Os critérios [(S + R X QRS], Sokolow-Lyon, Romhilt-Estes, Perúgia e padrão strain mostraram alto poder discriminatório no diagnóstico de HVE entre homens e mulheres nos três grupos de HVE, com desempenho superior na população masculina e destaque para os escores [(S + R X QRS] e Perúgia. CONCLUSÃO: A sensibilidade diagnóstica do ECG é maior com o aumento da massa cardíaca. O exame é mais sensível entre homens, destacando-se os escores [(S + R X QRS] e Perúgia.BACKGROUND: Several factors are known to interfere with electrocardiogram (ECG sensitivity when diagnosing Left Ventricular Hypertrophy (LVH, with gender and cardiac mass being two of the most important ones OBJECTIVE: To evaluate the influence of gender on the sensitivity of some of the criteria used to detect LVH, according to the progression of ventricular hypertrophy degree. METHODS: According to gender and the degree of LVH at the echocardiogram, the patients were divided in three groups: mild, moderate and severe LVH. ECG sensitivity to detect LVH was assessed between men and women, according to the LVH degree. RESULTS: Of the 874 patients, 265 were males (30.3% and 609, females (69.7%. The [(S + R X QRS], Sokolow-Lyon, Romhilt-Estes, Perugia and strain criteria

  15. Medicare and Medicaid Statistical Supplement

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Office of Enterprise Data and Analytics (OEDA) produced an annual Medicare and Medicaid Statistical Supplement report providing detailed statistical...

  16. Added Value via SPI supplement

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supplement that indicates where to find the source data sets on the EPA system. This dataset is associated with the following publication: Bowden, J., K.D. Talgo, T....

  17. Why Take a Prenatal Supplement?

    Science.gov (United States)

    ... supplements combined. For women who are capable of becoming pregnant, 400 micrograms of folic acid from fortified ... paid attention to what I ate until my teacher asked us to use SuperTracker. I definitely learned ...

  18. Efeitos hemodinâmicos da combinação de dexmedetomidina-fentanil versus midazolam-fentanil em crianças submetidas à cirurgia cardíaca com circulação extracorpórea Efectos hemodinámicos de la combinación de dexmedetomidina-fentanil versus midazolam-fentanil en ninõs sometidos a la cirugía cardíaca con circulación extracorpórea Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass

    Directory of Open Access Journals (Sweden)

    Jyrson Guilherme Klamt

    2010-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Avaliar a eficácia da infusão combinada de dexmedetomidina e fentanil na resposta hemodinâmica durante cirurgia cardíaca com circulação extracorpórea (CEC em crianças. MÉTODO: Trinta e duas crianças com idade entre 1 mês e 10 anos, agendadas para cirurgia cardíaca com circulação extracorpórea, foram distribuídas de modo aleatório em dois grupos: o Grupo MDZ recebeu midazolam 0,2 mg.kg-1.h-1, enquanto o Grupo DEX recebeu dexmedetomidina 1 µg.kg-1.h-1 durante uma hora e, em seguida, o ritmo de infusão foi reduzido à metade em ambos os grupos. Ambos os grupos receberam fentanil 10 µg.kg-1, midazolam 0,2 mg.h-1 e vecurônio 0,2 mg.kg-1 para indução da anestesia. As mesmas doses de fentanil com vecurônio da indução foram infundidas durante a primeira hora após a indução e, em seguida, reduzidas à metade. As infusões foram iniciadas imediatamente após a indução e mantidas até o final da cirurgia. O isoflurano foi administrado por curto tempo para controle da resposta hiperdinâmica à incisão e esternotomia. RESULTADOS: Em ambos os grupos, a pressão arterial sistólica e a frequência cardíaca reduziram de modo significativo após uma hora de infusão anestésica, porém o aumento da pressão arterial sistólica e diastólica e da frequência cardíaca à incisão da pele foram significantemente menores no Grupo DEX. Um número significativamente menor de pacientes demandaram suplementação com isoflurano no Grupo DEX. Após a CEC, os pacientes de ambos os grupos tiveram respostas hemodinâmicas similares. CONCLUSÕES: A infusão sem bolus de dexmedetomidina parece ser um adjuvante efetivo do fentanil na promoção de sedação e controle das respostas hemodinâmicas durante cirurgia para cardiopatias congênitas em crianças.JUSTIFICATIVA Y OBJETIVOS: Evaluar la eficacia de la infusión combinada de dexmedetomidina y fentanil en la respuesta hedominámica durante la cirugía cardíaca

  19. Recombinant Acremonium chrysogenum strains for the industrial production of cephalosporin.

    Science.gov (United States)

    Díez, B; Mellado, E; Fouces, R; Rodríguez, M; Barredo, J L

    1996-09-01

    Conventional strain improvement programs based on random mutagenesis and rational screening have meant valuable results to the antibiotic producing companies. The development of recombinant DNA techniques and their applications to the industrially-used cephalosporin-producing fungus Acremonium chrysogenum has provided a new tool, complementary to classical mutation, promoting the design of alternative biosynthetic pathways making it possible to obtain new antibiotics and to improve cephalosporin production. Yield increases have been achieved by increasing the dosage of the biosynthetic genes cefEF (deacetoxycephalosporin C expandase/hydroxylase) and cefG (deacetylcephalosporin C acetyltransferase) or enhancing the oxygen uptake by expressing a bacterial oxygen-binding heme protein (Vitreoscilla hemoglobin). New biosynthetic capacities such as the production of 7-aminocephalosporanic acid (7-ACA) or penicillin G have been achieved through the expression of the foreign genes dao (D-amino acid oxidase) coupled with cephalosporin acylase or penDE(acyl-CoA:6-APA acyltransferase) respectively. Confined manipulation of the above-mentioned recombinant strains must be performed according to standing rules.

  20. Herbal Supplements: Cause for Concern?

    OpenAIRE

    Paolo Borrione; Luigi Di Luigi; Nicola Maffulli; Fabio Pigozzi

    2008-01-01

    More than 1400 herbal products or herbal-derived compounds are commonly commercialised for health uses worldwide (Tyler, 1996). Herbs are considered dietary supplements, and therefore are subjected to a very limited form of regulation, and advertisements normally highlight their potential activities without mentioning any side effect. Also, herbs are generally believed to be 'natural', and hence safe. Many nutritional supplements contains herb compounds usually not present in the diet (e.g. G...

  1. Vitamin D supplementation guidelines.

    Science.gov (United States)

    Pludowski, Pawel; Holick, Michael F; Grant, William B; Konstantynowicz, Jerzy; Mascarenhas, Mario R; Haq, Afrozul; Povoroznyuk, Vladyslav; Balatska, Nataliya; Barbosa, Ana Paula; Karonova, Tatiana; Rudenka, Ema; Misiorowski, Waldemar; Zakharova, Irina; Rudenka, Alena; Łukaszkiewicz, Jacek; Marcinowska-Suchowierska, Ewa; Łaszcz, Natalia; Abramowicz, Pawel; Bhattoa, Harjit P; Wimalawansa, Sunil J

    2017-02-12

    Research carried out during the past two-decades extended the understanding of actions of vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many pleiotropic actions in organs and tissues in the body. Most observational and ecological studies report association of higher serum 25-hydroxyvitamin D [25(OH)D] concentrations with improved outcomes for several chronic, communicable and non-communicable diseases. Consequently, numerous agencies and scientific organizations have developed recommendations for vitamin D supplementation and guidance on optimal serum 25(OH)D concentrations. The bone-centric guidelines recommend a target 25(OH)D concentration of 20ng/mL (50nmol/L), and age-dependent daily vitamin D doses of 400-800IU. The guidelines focused on pleiotropic effects of vitamin D recommend a target 25(OH)D concentration of 30ng/mL (75nmol/L), and age-, body weight-, disease-status, and ethnicity dependent vitamin D doses ranging between 400 and 2000IU/day. The wise and balanced choice of the recommendations to follow depends on one's individual health outcome concerns, age, body weight, latitude of residence, dietary and cultural habits, making the regional or nationwide guidelines more applicable in clinical practice. While natural sources of vitamin D can raise 25(OH)D concentrations, relative to dietary preferences and latitude of residence, in the context of general population, these sources are regarded ineffective to maintain the year-round 25(OH)D concentrations in the range of 30-50ng/mL (75-125nmol/L). Vitamin D self-administration related adverse effects, such as hypercalcemia and hypercalciuria are rare, and usually result from taking extremely high doses of vitamin D for a prolonged time. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Cardiovascular Effects of Calcium Supplements

    Directory of Open Access Journals (Sweden)

    Ian R. Reid

    2013-07-01

    Full Text Available Calcium supplements reduce bone turnover and slow the rate of bone loss. However, few studies have demonstrated reduced fracture incidence with calcium supplements, and meta-analyses show only a 10% decrease in fractures, which is of borderline statistical and clinical significance. Trials in normal older women and in patients with renal impairment suggest that calcium supplements increase the risk of cardiovascular disease. To further assess their safety, we recently conducted a meta-analysis of trials of calcium supplements, and found a 27%–31% increase in risk of myocardial infarction, and a 12%–20% increase in risk of stroke. These findings are robust because they are based on pre-specified analyses of randomized, placebo-controlled trials and are consistent across the trials. Co-administration of vitamin D with calcium does not lessen these adverse effects. The increased cardiovascular risk with calcium supplements is consistent with epidemiological data relating higher circulating calcium concentrations to cardiovascular disease in normal populations. There are several possible pathophysiological mechanisms for these effects, including effects on vascular calcification, vascular cells, blood coagulation and calcium-sensing receptors. Thus, the non-skeletal risks of calcium supplements appear to outweigh any skeletal benefits, and are they appear to be unnecessary for the efficacy of other osteoporosis treatments.

  3. Hipotermia terapêutica após parada cardíaca: preditores de prognóstico

    Directory of Open Access Journals (Sweden)

    Rodrigo Nazário Leão

    2015-12-01

    Full Text Available Resumo Objetivo: A determinação do prognóstico de pacientes em coma após parada cardíaca tem implicações clínicas, éticas e sociais. Exame neurológico, marcadores de imagem e bioquímicos são ferramentas úteis e bem aceitas na previsão da recuperação. Com o advento da hipotermia terapêutica, tais informações devem de ser confirmadas. Neste estudo procurou-se determinar a validade de diferentes marcadores que podem ser utilizados na detecção de pacientes com mau prognóstico durante um protocolo de hipotermia. Métodos: Foram coletados prospectivamente os dados de pacientes adultos, internados após parada cardíaca em nossa unidade de terapia intensiva para realização de protocolo de hipotermia. Nosso intuito foi realizar um estudo descritivo e analítico para analisar a relação entre os dados clínicos, parâmetros neurofisiológicos, de imagem e bioquímicos, e o desfecho após 6 meses, conforme definido pela escala Cerebral Performance Categories (bom, se 1-2, e mau, se 3-5. Foi coletada uma amostra para determinação de neuroenolase após 72 horas. Os exames de imagem e neurofisiológicos foram realizados 24 horas após o período de reaquecimento. Resultados: Foram incluídos 67 pacientes, dos quais 12 tiveram evolução neurológica favorável. Fibrilação ventricular e atividade teta no eletroencefalograma se associaram a bom prognóstico. Pacientes submetidos a resfriamento mais rápido (tempo médio de 163 versus 312 minutos, com lesão cerebral causada por hipóxia/isquemia detectada na ressonância nuclear magnética ou níveis de neuroenolase superiores a 58ng/mL se associaram a desfecho neurológico desfavorável (p < 0,05. Conclusão: A presença de lesão cerebral causada por hipóxia/isquemia e de neuroenolase foram fortes preditores de má evolução neurológica. Apesar da crença de que atingir rapidamente a temperatura alvo da hipotermia melhora o prognóstico neurológico, nosso estudo demonstrou

  4. Food Supplement Usage by Adolescent Males.

    Science.gov (United States)

    Fleischer, Barbara; Read, Marsha

    1982-01-01

    Adolescent males (N=568) responded to a questionnaire examining their food supplement usage, types of food supplements consumed, reasons for use and non-use, relationship of use to concern for health, and demographic and external factors influencing supplement use. Presents factors related to food supplement usage. (RC)

  5. Anemia, insuficiência cardíaca e manejo clínico baseado em evidências

    Directory of Open Access Journals (Sweden)

    Camila Alves Pereira

    2013-07-01

    Full Text Available A anemia é uma comorbidade prevalente e marcadora de pior prognóstico em pacientes com insuficiência cardíaca (IC. Sua relevância clínica, bem como a fisiopatologia e abordagem terapêutica nesses pacientes são temas de destaque na literatura especializada. Nessa revisão são descritos os conceitos atuais sobre a fisiopatologia da anemia na IC, os critérios diagnósticos e as indicações da suplementação de ferro, ao mesmo tempo em que são analisados criticamente os principais estudos que ofereceram evidências sobre os benefícios dessa suplementação. São abordados os quatro componentes principais da anemia: doença crônica, dilucional, "renal" e disabsortiva. Nos pacientes com IC, os critérios para o diagnóstico são os mesmos utilizados na população geral: níveis de ferritina sérica inferiores a 30 mcg/L em pacientes não nefropatas e menores que 100 mcg/L ou ferritina sérica entre 100-299 mcg/L com saturação de transferrina menor que 20% em pacientes com doença renal crônica. Finalmente, são discutidas as possibilidades terapêuticas da anemia nessa população específica de pacientes.

  6. Lesões cardíacas em ratos wistar inoculados com diferentes cepas do Trypanosoma cruzi

    Directory of Open Access Journals (Sweden)

    E. Chapadeiro

    1988-09-01

    Full Text Available Ratos albinos Wistar infectados com diferentes inóculos das cepas Y, Colombiana (COL e São Felipe (12SF do Trypanosoma cruzi desenvolveram parasitemia elevada entre 14e21 dias, a qual tomou-se desprezível ou desapareceu completamente ao final da 4ª semana. As lesões do coração foram avaliadas, semiquantitativamente, pelo sistema de "scores", conforme a intensidade e a extensão da inflamação, nas diferentes estruturas do órgão, tendo sido observado que: a na fase inicial (aguda da infecção, os animais mortos espontaneamente ou em conseqüência de acidente anestésico apresentaram cardite de intensidade moderada à acentuada, não havendo diferença em relação às cepas utilizadas; as diferentes estruturas do coração estavam uniformemente comprometidas; b na fase crônica da infecção observou-se cardite degrau leve a moderado e as lesões foram mais freqüentes e intensas quanto maior o inoculo empregado; no entanto, inóculos baixos só produziram lesões quando a cepa utilizada foi a Colombiana. Trombose mural nos átrios e dilatação da ponta do ventrículo esquerdo foram observadas em 20% dos animais, independentemente da cepa. Na fase crônica 15% dos animais apresentaram miocardite crônica com fibrose, associada à hipertrofia das miocélulas. Os AA confirmam ser o rato albino suscetível à infecção chagásica e, portanto, um modelo útil no estudo das manifestações cardíacas da Doença de Chagas.

  7. Obturator internus muscle strains

    Directory of Open Access Journals (Sweden)

    Caoimhe Byrne, MB BCh, BAO

    2017-03-01

    Full Text Available We report 2 cases of obturator internus muscle strains. The injuries occurred in young male athletes involved in kicking sports. Case 1 details an acute obturator internus muscle strain with associated adductor longus strain. Case 2 details an overuse injury of the bilateral obturator internus muscles. In each case, magnetic resonance imaging played a crucial role in accurate diagnosis.

  8. Mediastinite pós-esternotomia longitudinal para cirurgia cardíaca: 10 anos de análise

    Directory of Open Access Journals (Sweden)

    Valdir Cesarino de Souza

    2002-09-01

    Full Text Available INTRODUÇÃO: mediastinites pós-esternotomia para cirurgia cardíaca não são freqüentes (0,2% a 5,0%, porém, quando surgem, se tornam potencialmente graves. Mesmo com o diagnóstico e tratamento precoces, o prognóstico não é bom, sobretudo se houver sepse e outros agravos à saúde associados. OBJETIVO: rever a casuística de casos de mediastinite. MÉTODO: foram analisados os prontuários de 2.272 pacientes submetidos à cirurgia cardíaca entre 1991 e 2000. Todas as operações foram realizadas através de esternotomia mediana longitudinal e circulação extracorpórea no Hospital João XXIII / Instituto de Cirurgia Cardiovascular da Paraíba de Campina Grande (Paraíba. RESULTADOS: a mediastinite ocorreu, em média, 10 dias após a cirurgia, num total de 37 (1,6% casos, com taxa de letalidade 21,6% (n=8. A maioria (n=19; 51,4% dos casos foi em pacientes submetidos a revascularização do miocárdio, seguidos pelos procedimentos valvares (n=13; 35,1%, correções de cardiopatias congênitas (n=4; 10,8% e aneurisma de aorta ascendente (n=1; 2,7%. Vários fatores de risco foram identificados (obesidade, tempo de permanência hospitalar prolongado, diabetes mellitus, tabagismo, reoperações e cirurgias de emergência, especialmente a permanência (por mais de 72 horas no pré-operatório em unidade de terapia intensiva. A cultura do exsudato foi positiva em 35 (94,6% dos 37 pacientes, sendo o Staphylococcus aureus o patógeno mais observado em 17 (48,6%. CONCLUSÕES: a freqüência de mediastinite pós-cirurgias cardíaca, com esternotomia associada, é semelhante à descrita na literatura, não tem diminuído no decorrer dos anos, por isto continua representando um desafio para os cirurgiões e equipes, apesar do arsenal diagnóstico e terapêutico atuais.INTRODUCTION: Mediastinitis is a rare though potentially fatal complication. The incidence is reported to be between 0.2% and 5.0% and is a major cause of postoperative morbidity

  9. Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases.

    Science.gov (United States)

    Lenormand, Cédric; Jaulhac, Benoît; Debarbieux, Sébastien; Dupin, Nicolas; Granel-Brocard, Florence; Adamski, Henri; Barthel, Cathy; Cribier, Bernard; Lipsker, Dan

    2016-04-01

    The diagnosis of acrodermatitis chronica atrophicans (ACA), the late cutaneous manifestation of Lyme borreliosis, can be challenging. Histologic changes in ACA have been described in a few studies from endemic countries, relying on cases documented by serology only. We sought to reassess the clinicopathological spectrum of ACA in a series of thoroughly documented cases. Patients prospectively included in a national prospective study were selected on the basis of positive culture and/or polymerase chain reaction of a skin biopsy sample. The diagnosis of ACA was confirmed by reviewing the clinical and serologic data. Histopathological samples were carefully reviewed. Twenty patients were included. Unusual clinical features (ie, numerous small violaceous patches and equidistant small spinous papules with background faint erythema) were observed in 2 patients. Histopathological examination revealed a classic plasma cell-rich perivascular and interstitial pattern with telangiectases in 16 of 25 samples, whereas strikingly prominent granuloma annulare-like or lichenoid features were observed in 4 and 2 of 25 cases, respectively, and discrete nonspecific minor changes in 3 of 25 cases. The small number of patients was a limitation. Genuine culture- and/or polymerase chain reaction-proven ACA can rarely present as numerous violaceous patches or cluster of spinous papules clinically, and as a granuloma annulare-like or lichenoid dermatosis histologically. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  10. The ability of Clostridium bifermentans strains to lactic acid biosynthesis in various environmental conditions

    OpenAIRE

    Leja, Katarzyna; Myszka, Kamila; Czaczyk, Katarzyna

    2013-01-01

    Clostridium bifermentans strains, isolated from a manure, were examinated for their ability to produce lactic acid from PY medium with glycerol under different pH conditions and when PY medium was supplemented with saccharides such as fructose, sorbitol, glucose, mannose, mannitol, maltose, xylose, raffinose, and arabinose. In the last test performed, the ability of investigated strains to produce lactic acid from mixed carbon source (glycerol plus saccharide) was checked. The strains of Cl. ...

  11. Fisher: a program for the detection of H/ACA snoRNAs using MFE secondary structure prediction and comparative genomics – assessment and update

    Directory of Open Access Journals (Sweden)

    Tamas Ivica

    2008-07-01

    Full Text Available Abstract Background The H/ACA family of small nucleolar RNAs (snoRNAs plays a central role in guiding the pseudouridylation of ribosomal RNA (rRNA. In an effort to systematically identify the complete set of rRNA-modifying H/ACA snoRNAs from the genome sequence of the budding yeast, Saccharomyces cerevisiae, we developed a program – Fisher – and previously presented several candidate snoRNAs based on our analysis 1. Findings In this report, we provide a brief update of this work, which was aborted after the publication of experimentally-identified snoRNAs 2 identical to candidates we had identified bioinformatically using Fisher. Our motivation for revisiting this work is to report on the status of the candidate snoRNAs described in 1, and secondly, to report that a modified version of Fisher together with the available multiple yeast genome sequences was able to correctly identify several H/ACA snoRNAs for modification sites not identified by the snoGPS program 3. While we are no longer developing Fisher, we briefly consider the merits of the Fisher algorithm relative to snoGPS, which may be of use for workers considering pursuing a similar search strategy for the identification of small RNAs. The modified source code for Fisher is made available as supplementary material. Conclusion Our results confirm the validity of using minimum free energy (MFE secondary structure prediction to guide comparative genomic screening for RNA families with few sequence constraints.

  12. Controle da dor no pós-operatório de cirurgia cardíaca: uma breve revisão

    Directory of Open Access Journals (Sweden)

    Luciano Ramos de Lima

    2008-06-01

    Full Text Available Este estudo teve como objetivo identificar as terapêuticas analgésicas para controle da dor no pós-operatório de pacientes submetidos à cirurgia cardíaca e os instrumentos utilizados para mensurar a experiência dolorosa. Trata-se de uma pesquisa bibliográfica realizada por meio de revisão da literatura nas bases de dados eletrônicos LILACS, revistas eletrônicas da SciELO, dissertações e teses. Foram utilizados os descritores analgesia, analgesia controlada pelo paciente, cirurgia cardíaca, avaliação e dor pós-operatória. O levantamento dos dados ocorreu em maio de 2007 e foram selecionados estudos publicados no período de maio de 1997 a maio de 2007. Na análise realizou-se síntese reflexiva dos estudos. Dos 23 estudos levantados foram utilizados 8 artigos e uma dissertação de mestrado. A técnica de analgesia mais utilizada foi a Analgesia Controlada pelo Paciente (ACP e os medicamentos mais utilizado foram os opióides, como a morfina, seguidos por antiflamatórios não esteroidais (AINEs e dipirona. Não foram encontrados estudos que utilizaram a terapêutica não farmacológica. Os instrumentos de avaliação de dor frequentemente utilizados nestes estudos incluíram as escalas unidimensionais como a escala numérica verbal e a escala analógica visual. Ficou também evidenciado que os enfermeiros estão pouco envolvidos em pesquisas que abordam o controle da dor no período pós-operatório de cirurgia cardíaca.

  13. AVALIAÇÃO DE SAÚDE E DA DOR NO PÓS-OPERATÓRIO DE IDOSOS SUBMETIDOS À CIRURGIA CARDÍACA

    Directory of Open Access Journals (Sweden)

    Thaiza Teixeira Xavier

    2011-01-01

    Full Text Available El presente estudio tiene como objetivo evaluar la salud y el dolor en pacientes ancianos con insuficiencia coronaria sometidos a cirugía cardíaca. Esta es una investigación de carácter analítico, transversal, con enfoque cuantitativo. La recolección de los datos se hizo por medio de una ficha de evaluación fisioterapéutica usando también la escala numérica de dolor, con 70 pacientes ancianos sometidos a cirugía cardíaca en dos hospitales en la ciudad de Natal/RN, Brasil. El rango de edad más frecuente fue de 60 a 69 años (61,43%, mayoría hombres (62,86%. En relación con el estado de salud el 61,43% de los sujetos tenían enfermedades preexistentes, siendo la de mayor distribución la hipertensión arterial (31.40%. El comportamiento del dolor fue moderado en el 1º y 3º días, y leve en el 2º y 4º días después de la operación. Por lo tanto, se constató que la mayoría de los pacientes ancianos sometidos a cirugía cardíaca eran del sexo masculino, que tenían patologías preexistentes, con la hipertensión arterial como la patología mas frecuente y con predominio de la intensidad del dolor moderado

  14. Computational prediction and validation of C/D, H/ACA and Eh_U3 snoRNAs of Entamoeba histolytica

    Directory of Open Access Journals (Sweden)

    Kaur Devinder

    2012-08-01

    Full Text Available Abstract Background Small nucleolar RNAs are a highly conserved group of small RNAs found in eukaryotic cells. Genes encoding these RNAs are diversely located throughout the genome. They are functionally conserved, performing post transcriptional modification (methylation and pseudouridylation of rRNA and other nuclear RNAs. They belong to two major categories: the C/D box and H/ACA box containing snoRNAs. U3 snoRNA is an exceptional member of C/D box snoRNAs and is involved in early processing of pre-rRNA. An antisense sequence is present in each snoRNA which guides the modification or processing of target RNA. However, some snoRNAs lack this sequence and often they are called orphan snoRNAs. Results We have searched snoRNAs of Entamoeba histolytica from the genome sequence using computational programmes (snoscan and snoSeeker and we obtained 99 snoRNAs (C/D and H/ACA box snoRNAs along with 5 copies of Eh_U3 snoRNAs. These are located diversely in the genome, mostly in intergenic regions, while some are found in ORFs of protein coding genes, intron and UTRs. The computationally predicted snoRNAs were validated by RT-PCR and northern blotting. The expected sizes were in agreement with the observed sizes for all C/D box snoRNAs tested, while for some of the H/ACA box there was indication of processing to generate shorter products. Conclusion Our results showed the presence of snoRNAs in E. histolytica, an early branching eukaryote, and the structural features of E. histolytica snoRNAs were well conserved when compared with yeast and human snoRNAs. This study will help in understanding the evolution of these conserved RNAs in diverse phylogenetic groups.

  15. Estratégias de prevenção da lesão renal aguda em cirurgia cardíaca: revisão integrativa

    Directory of Open Access Journals (Sweden)

    Eduesley Santana-Santos

    2014-04-01

    Full Text Available A lesão renal aguda é uma complicação frequente após cirurgia cardíaca, estando associada ao aumento de morbidade e mortalidade, e ao maior tempo de permanência em unidade de terapia intensiva. Considerando a alta prevalência e a associação da lesão renal aguda com o pior prognóstico, o desenvolvimento de estratégias de proteção renal torna-se indispensável, especialmente em pacientes com alto risco para o desenvolvimento de lesão renal aguda, como aqueles submetidos à cirurgia cardíaca, com o intuito de minimizar a incidência da lesão renal aguda no âmbito hospitalar, reduzindo, dessa forma, a alta morbimortalidade. A presente revisão integrativa teve por objetivo avaliar as evidências disponíveis na literatura sobre as intervenções mais eficazes na prevenção da lesão renal aguda em pacientes submetidos à cirurgia cardíaca. Para seleção dos artigos, utilizaram-se as bases de dados CINAHL e MedLine. A amostra desta revisão constituiu-se de 16 artigos. Após a análise dos artigos incluídos na revisão, os resultados dos estudos apontaram que apenas a hidratação com solução salina apresenta resultados consideráveis na prevenção de lesão renal aguda. As demais estratégias são controversas e necessitam de mais pesquisas para comprovar eficácia.

  16. A strain gauge

    DEFF Research Database (Denmark)

    2016-01-01

    The invention relates to a strain gauge of a carrier layer and a meandering measurement grid positioned on the carrier layer, wherein the strain gauge comprises two reinforcement members positioned on the carrier layer at opposite ends of the measurement grid in the axial direction....... The reinforcement members are each placed within a certain axial distance to the measurement grid with the axial distance being equal to or smaller than a factor times the grid spacing. The invention further relates to a multi-axial strain gauge such as a bi-axial strain gauge or a strain gauge rosette where each...... of the strain gauges comprises reinforcement members. The invention further relates to a method for manufacturing a strain gauge as mentioned above....

  17. Boron supplementation in broiler diets

    Directory of Open Access Journals (Sweden)

    EJ Fassani

    2004-12-01

    Full Text Available Boron supplementation in broiler feed is not a routine practice. However, some reports suggest a positive effect of boron on performance. This study assessed the effects of boron supplementation on broiler performance. Diets were based on maize and soybean meal, using boric acid P.A. as boron source. Six supplementation levels (0, 30, 60, 90, 120 and 150 ppm were evaluated using 1,440 one-day old males housed at a density of 30 chickens in each of 48 experimental plots of 3m². A completely randomized block design was used with 8 replicates. Feed intake, weight gain and feed conversion were assessed in the periods from 1 to 7 days, 1 to 21 days and 1 to 42 days of age, and viability was evaluated for the total 42-day rearing period. No performance variable was affected by boron supplementation (p>0.05 in the period from 1 to 7 days. The regression analysis indicated an ideal level of 37.4 ppm of boron for weight gain from 1 to 21 days (p0.05, although feed intake was reduced linearly with increased boron levels (p0.05. Ash and calcium percentages in the tibias of broilers and viability in the total rearing period were not affected by boron supplementation (p>0.05.

  18. Environmental Report 2000 Data Supplement

    Energy Technology Data Exchange (ETDEWEB)

    Biermann, A H; Althouse, P E; Bertoldo, N A; Blake, R G; Brigdon, S L; Brown, R A; Campbell, C G; Christofferson, E; Clark, L M; Folks, K J; Gallegos, G M; Grayson, A R; Harrach, R J; Larson, J M; MacQueen, D H; Mathews, S; Nisbet, B; Ring Peterson, S; Taffet, M J; Tate, P J; Vellinger, R J; Williams, R A

    2001-09-01

    This Data Supplement to the Lawrence Livermore National Laboratory's (LLNL's) annual ''Environmental Report 2000'' was prepared for the U.S. Department of Energy. The main volume is intended to provide all information on LLNL's environmental impact and compliance activities that is of interest to most readers. The Data Supplement supports main volume summary data and is essentially a detailed data report that provides individual data points, where applicable. Some summary data are also included in the Data Supplement, and more detailed accounts are given of sample collection and analytical methods. The two volumes are organized in a parallel fashion to aid the reader in cross-referencing between them. This supplement includes more detailed information to support the nine chapters in the main volume that cover monitoring of air surveillance, air effluent, sewerable water, surface water, groundwater, soil and sediment, vegetation and foodstuff, environmental radiation, and quality assurance. The other five chapters in the main volume have no supporting information in the Data Supplement. As in our previous annual reports, data are presented in Systeme International (SI) units. In particular, the primary units used for radiological results are becquerels and sieverts for activity and dose, with curies and rem used secondarily (1 Bq = 2.7 x 10{sup -11} Ci; 1 Sv = 100 rem).

  19. Environmental Report 1999 Data Supplement

    Energy Technology Data Exchange (ETDEWEB)

    Larson, J M; Biermann, A H; Harrach, R J; Althouse, P E; Bertoldo, N A; Blake, R G; Brandstetter, E R; Brigdon, S L; Brown, R A; Christofferson, E; Folks, K J; Gallegos, G M; Garcia, L M; Giesing, T A; Grayson, A R; Hall, L C; MacQueen, D H; Mathews, S; Peterson, S R; Taffet, M J; Tate, P J; Vellinger, R J; Ward, R J; Williams, R A

    2000-09-01

    This Data Supplement to the Lawrence Livermore National Laboratory's (LLNL's) annual ''Environmental Report 1999'' was prepared for the U.S. Department of Energy. The main volume is intended to provide all information on LLNL's environmental impact and compliance activities that is of interest to most readers. The Data Supplement supports main volume summary data and is essentially a detailed data report that provides individual data points, where applicable. Some summary data are also included in the Data Supplement, and more detailed accounts are given of sample collection and analytical methods. The two volumes are organized in a parallel fashion to aid the reader in cross-referencing between them. This supplement includes more detailed information to support the nine chapters in the main volume that cover monitoring of air, air effluent, sewerable water, surface water, ground water, soil and sediment, vegetation and foodstuff, environmental radiation, and quality assurance. The other five chapters in the main volume have no supporting information in the Data Supplement. As in our previous annual reports, data are presented in Systeme International (SI) units. In particular, the primary units used for radiological results are becquerels and sieverts for activity and dose, with curies and rem used secondarily (1 Bq = 2.7 x 10{sup -11} Ci; 1 Sv = 100 rem).

  20. Vitamin C supplementation in pregnancy.

    Science.gov (United States)

    Rumbold, Alice; Ota, Erika; Nagata, Chie; Shahrook, Sadequa; Crowther, Caroline A

    2015-09-29

    Vitamin C supplementation may help reduce the risk of pregnancy complications such as pre-eclampsia, intrauterine growth restriction and maternal anaemia. There is a need to evaluate the efficacy and safety of vitamin C supplementation in pregnancy. To evaluate the effects of vitamin C supplementation, alone or in combination with other separate supplements on pregnancy outcomes, adverse events, side effects and use of health resources. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2015) and reference lists of retrieved studies. All randomised or quasi-randomised controlled trials evaluating vitamin C supplementation in pregnant women. Interventions using a multivitamin supplement containing vitamin C or where the primary supplement was iron were excluded. Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. Twenty-nine trials involving 24,300 women are included in this review. Overall, 11 trials were judged to be of low risk of bias, eight were high risk of bias and for 10 trials it was unclear. No clear differences were seen between women supplemented with vitamin C alone or in combination with other supplements compared with placebo or no control for the risk of stillbirth (risk ratio (RR) 1.15, 95% confidence intervals (CI) 0.89 to 1.49; 20,038 participants; 11 studies; I² = 0%; moderate quality evidence), neonatal death (RR 0.79, 95% CI 0.58 to 1.08; 19,575 participants; 11 studies; I² = 0%), perinatal death (average RR 1.07, 95% CI 0.77 to 1.49; 17,105 participants; seven studies; I² = 35%), birthweight (mean difference (MD) 26.88 g, 95% CI -18.81 to 72.58; 17,326 participants; 13 studies; I² = 69%), intrauterine growth restriction (RR 0.98, 95% CI 0.91 to 1.06; 20,361 participants; 12 studies; I² = 15%; high quality evidence), preterm birth (average RR 0.99, 95% CI 0.90 to 1.10; 22,250 participants; 16 studies; I² = 49%; high quality evidence

  1. 92. Desarrollo y resultados iniciales de un programa de cirugía cardíaca robótica. ¿Qué hemos aprendido?

    Directory of Open Access Journals (Sweden)

    J.M. Borrego Domínguez

    2010-01-01

    Conclusiones: La cirugía cardíaca asistida por Da Vinci puede facilitar los procedimientos mínimamente invasivos, siendo segura y de similares resultados a la convencional. Es fundamental diseñar un programa de entrenamiento por fases para su desarrollo y una adecuada selección de los pacientes para la curva de aprendizaje. Con esto se consigue que, aunque con tiempos operatorios mayores, no presente aumento de la morbimortalidad frente a las técnicas consolidadas.

  2. Actualidades del catéter de flotación pulmonar en cirugía cardíaca

    OpenAIRE

    Fernández Rivera,Bernardo Javier

    2006-01-01

    El catéter de flotación pulmonar fue introducido hace más de 30 años en la clínica, una de sus principales aplicaciones ha sido la cirugía cardíaca, los valores hemodinámicos obtenidos de su uso se han tratado sin éxito de sustituir por medios no invasivos, existen áreas de controversia acerca de su utilidad, encontrando en la literatura estudios contradictorios acerca del valor de su uso, estos estudios se refieren en general al paciente quirúrgico, y no existen estudios concluyentes en ciru...

  3. Monitorização intraoperatória com ecocardiografia transesofágica em cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Carlos Galhardo Júnior

    2011-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Desde a sua introdução clínica na década de 1980, a ecocardiografia transesofágica (ETE intraoperatória tem representado um dos maiores avanços na anestesia cardíaca moderna. Trata-se de uma técnica semi-invasiva, que permite visualização direta e rápida da anatomia estrutural do coração e dos grandes vasos, além de contribuir para a avaliação hemodinâmica e funcional do sistema cardiovascular. Dessa maneira, tem-se tornado importante monitor para auxílio diagnóstico de patologias cardíacas e intervenções anestésico-cirúrgicas. O objetivo do artigo é realizar uma revisão abrangente sobre a utilização da ETE no intraoperatório de cirurgia cardíaca. CONTEÚDO: O artigo revisa alguns aspectos relacionados à física do ultrassom, as técnicas para a obtenção das imagens, os cortes ecocardiográficos mais utilizados no intraoperatório, as indicações e as principais aplicações clínicas do método, além das contraindicações e complicações. CONCLUSÕES: A ETE intraoperatória é um método de monitorização cardiovascular seguro e útil na formulação do plano cirúrgico, na orientação de intervenções hemodinâmicas e na avaliação imediata do resultado operatório. O anestesiologista, uma vez habilitado à utilização do método, amplia seu papel no contexto da medicina perioperatória, fornecendo informações clínicas imprescindíveis à condução do ato anestésico-cirúrgico em cirurgia cardíaca.

  4. Aspectos da personalidade e sua influência na percepção da dor aguda em pacientes submetidos à cirurgia cardíaca

    OpenAIRE

    Thaiza Teixeira Xavier Nobre; Luciana Araújo dos Reis; Gilson de Vasconcelos Torres; João Carlos Alchieri

    2011-01-01

    OBJETIVO: Verificar o papel e a influência da personalidade na percepção dolorosa aguda de pacientes submetidos à cirurgia cardíaca. MÉTODO: Trata-se de uma pesquisa transversal, analítica, prospectiva de caráter correlacional, realizada em Natal, Rio Grande do Norte, Brasil. A amostra foi composta por 25 pacientes, sendo 64% do sexo feminino, com menos de 60 anos (52%). RESULTADOS: A intensidade dolorosa foi avaliada pela escala numérica de dor do primeiro ao quinto dia de pós-operatório e o...

  5. Fibrilação atrial no pós-operatório de cirurgia cardíaca: quem deve receber quimioprofilaxia?

    Directory of Open Access Journals (Sweden)

    Glaucylara Reis Geovanini

    2009-04-01

    Full Text Available Avaliar fatores de risco arritmogênicos associados à maior incidência de fibrilação atrial (FA no pós-operatório (PO de cirurgia cardíaca (revascularização miocárdica e/ou cirurgia valvar, com o intuito de selecionar os mais propensos ao desenvolvimento dessa arritmia para possível quimioprofilaxia. Avaliarem-se 66 pacientes submetidos à cirurgia cardíaca eletiva. Correlacionaram-se os principais fatores de risco (idade avançada, doença valvar (DV, aumento atrial esquerdo (AE, disfunção ventricular (DVE, distúrbio eletrolítico (DHE, cirurgia cardíaca prévia (CCP, uso prévio e suspensão de betabloqueador (B-Bloq e/ou digital 24 horas antes da cirurgia para o desenvolvimento de FA no PO. A incidência de FA foi elevada (47% em nossa casuística e mais freqüente no primeiro dia de PO. Dos pacientes pesquisados, 64% eram do sexo masculino com idade média de 62 anos. Entre os pacientes com dois ou menos fatores de risco para FA, apenas 24% desenvolveram a arritmia, enquanto a presença de três ou mais desses fatores esteve associada à sua maior incidência no PO (69%, (p = 0,04. Em ordem de maior freqüência, idade > 65 anos (em 58% dos pacientes foi o fator de risco mais prevalente, seguido de aumento do AE em 45% (p = 0,001 e DV em 38% (p = 0,02. A presença de três ou mais fatores de risco aumenta consideravelmente a incidência dessa arritmia no PO de cirurgia cardíaca. Entre os principais fatores, destacaram-se idade avançada, aumento do AE e doença valvar.

  6. Aneurisma de artéria ilíaca interna roto: relato de caso Ruptured internal iliac artery aneurysm: case report

    Directory of Open Access Journals (Sweden)

    Cristina Toledo Afonso

    2009-03-01

    Full Text Available Aneurismas isolados da artéria ilíaca interna são raros, acometem 0,1% da população e correspondem a 1% dos aneurismas aorto-ilíacos. Na maioria das vezes, os pacientes são assintomáticos, mas podem apresentar dor abdominal, massa pulsátil no hipogástrio ou na fossa ilíaca, sintomas compressivos urinários, gastrointestinais ou neurológicos. Podem ocasionar quadro de abdome agudo, principalmente quando há ruptura. O diagnóstico precoce dos aneurismas isolados de artéria ilíaca interna é incomum, sendo identificados quando mais volumosos ou rotos, o que aumenta significativamente sua morbimortalidade e torna seu prognóstico mais reservado. Dessa forma, representam um desafio terapêutico. A ligadura cirúrgica tem sido o tratamento mais comum, entretanto a cirurgia endovascular tem mostrado bons resultados, inclusive nos aneurismas rotos. É relatado caso de aneurisma de artéria ilíaca interna isolado roto diagnosticado durante laparotomia para abordagem de abdome agudo.Isolated internal iliac artery aneurysms are rare. They affect 0.1% of the population, and account for 1% of aortoiliac aneurysms. Patients are mostly asymptomatic, yet they can have abdominal pain, pulsatile mass in the hypogastrium or iliac fossa, or urinary, gastrointestinal or neurological compressive symptoms. Such aneurysms are likely to course with an acute abdomen, especially when ruptured. Early diagnosis of isolated internal iliac artery aneurysms is difficult, as they are more easily detected when larger or ruptured, which significantly raises their morbidity and mortality rate and determines a poor prognosis. Therefore, they are a therapeutic challenge. Surgical ligation has been the most common treatment; however, the endovascular approach has presented good outcomes, even in the event of ruptured aneurysms. A case of ruptured isolated iliac artery aneurysm diagnosed during a laparotomy (acute abdomen approach is reported.

  7. Selección de pacientes a terapia de resincronización cardíaca: El papel de la ecocardiografía

    OpenAIRE

    Cué-Carpio,Ramón José; Bucio-Reta,Eduardo; Navarrete-Gaona,Raúl; Guadalajara Boo,José F

    2007-01-01

    La insuficiencia cardíaca es una de las enfermedades emergentes en los países desarrollados, especialmente en personas mayores de 65 años. En las últimas 2 décadas se han utilizado nuevos esquemas terapéuticos que por primera vez han logrado reducir la mortalidad y con ello mejorar la supervivencia de estos enfermos. Sin embargo, a pesar de estos avances terapéuticos y otros implementos tecnológicos como la asistencia ventricular y el trasplante cardíaco, la mortalidad continúa siendo elevada...

  8. Análisis descriptivo y experimental de los procesos de diferenciación del área cardíaca de Bufo arenarum

    OpenAIRE

    Paz, Dante Agustín

    1987-01-01

    La diferenciación tisular, la constitución de la forma y la aparición de la función de los distintos órganos embrionarios, dependen de complicados procesos que involucran interacciones específicas entre las varias células y entre grupos celulares de distinto significado. No escapa de esta vasta problemática, la diferenciación del área cardíaca para la que intervienen interacciones celulares y más específicamente mecanismos de inducción embrionaria. Por lo tanto hemos considerado de interes re...

  9. Disección espontánea de arteria ilíaca asociada a ejercicio y uso de ergotamina

    OpenAIRE

    Fuenzalida G,Juan Pablo; Puentes R,Angel; Terrazas F,Sebastián; Osorio V,Sandra; Vergara C,Jorge; Schwartz Y,Eitan; Soumastre Ch,Rubén

    2012-01-01

    Introducción: La disección espontánea de la arteria ilíaca es un cuadro muy poco frecuente asociado a diferentes etiologías que habitualmente se presenta como isquemia de la extremidad comprometida. Caso clínico: Se reporta el caso de un paciente masculino de 48 años con antecedente de consumo crónico de ergotamina, quien mientras practicaba deporte presenta cuadro de isquemia aguda de la extremidad inferior izquierda. Angio tomografía computada demostró disección espontánea de la arteria ilí...

  10. Efeito antiarritmico do carvedilol na arritmia cardíaca experimentalmente induzida pela adrenalina em cães anestesiados com tiopental e halotano

    OpenAIRE

    Rocha, Taís Marchand

    2005-01-01

    Orientador: Prof. Antonio Felipe Paulino de Figueiredo Wouk Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Agrárias, Programa de Pós-Graduação em Ciencias Veterinárias. Defesa: Curitiba, 01/04/2005 Inclui bibliografia Resumo: Este estudo foi realizado a fim de investigar o efeito antiarrítmico do carvedilol na arritmia cardíaca experimental induzida pela adrenalina em cães anestesiados com tiopental e halotano. O carvedilol é um bloqueador adrenérgico não ...

  11. Insuficiência cardíaca. Uma epidemia do século XXI. O desafio do diagnóstico

    OpenAIRE

    Fonseca, Maria Cândida Faustino Gamito da

    2008-01-01

    Resumo: A insuficiência cardíaca, já denominada de epidemia do século XXI é, de entre as doenças cardiovasculares, a única cuja incidência e prevalência continuam a crescer, apesar dos imensos progressos feitos na área da terapêutica nas últimas duas décadas. Caracteriza-se por elevada mortalidade – superior à do conjunto das neoplasias malignas -, grande morbilidade, consumo de recursos e custos exuberantes. É um dos problemas mais graves de Saúde Pública dos Países industrializados, cujo ma...

  12. Fístula Arterio-Venosa Cerebral no Recém-Nascido — Uma Causa de Insuficiência Cardíaca Grave

    OpenAIRE

    Henriques, Graça; Duarte, Leonor; Amaral, João Videira; Ferreira, Manuel,; J. Macedo, António; Lima, Manuela

    2014-01-01

    A propósito de dois casos clínicos em que a principal manifestação foi a insuficiência cardíaca congestiva grave relacionada com a existência de fístula arterio-venosa cerebral, os autores salientam a importância do. diagnóstico precoce desta doença, se possível ainda antes do nascimento. Uma abordagem multidisciplinar, e uma terapêutica precoce de encerramento da fístula permite contribuir, deste modo, para a redução da morbilidade e da mortalidade associada a esta patologia.

  13. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8

    DEFF Research Database (Denmark)

    Tidow, Henning; Hein, Kim Langmach; Bækgaard, Lone

    2010-01-01

    -bound calmodulin (Ca(2+)-CaM) to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain. The complex between calmodulin and the regulatory domain of the plasma-membrane Ca(2+)-ATPase ACA8 from Arabidopsis thaliana has been crystallized. The crystals belonged to space......Plasma-membrane Ca(2+)-ATPases (PMCAs) are calcium pumps that expel Ca(2+) from eukaryotic cells to maintain overall Ca(2+) homoeostasis and to provide local control of intracellular Ca(2+) signalling. They are of major physiological importance, with different isoforms being essential, for example...

  14. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8

    DEFF Research Database (Denmark)

    Tidow, Henning; Hein, Kim Langmach; Palmgren, Michael Broberg

    2010-01-01

    -bound calmodulin (Ca2+-CaM) to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain. The complex between calmodulin and the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8 from Arabidopsis thaliana has been crystallized. The crystals belonged to space......Plasma-membrane Ca2+-ATPases (PMCAs) are calcium pumps that expel Ca2+ from eukaryotic cells to maintain overall Ca2+ homoeostasis and to provide local control of intracellular Ca2+ signalling. They are of major physiological importance, with different isoforms being essential, for example...

  15. Riesgo asociado a la cirugía cardíaca mayor en pacientes octogenarios : una revisión sistemática de la literatura.

    OpenAIRE

    2012-01-01

    Introducción: La enfermedad cardiovascular es la principal causa de muerte a nivel mundial, afectando principalmente la salud pública de países pobres con economías emergentes. La transición epidemiológica en Colombia ha incrementado la proporción de pacientes ancianos con enfermedad cardiovascular y que requieren cirugía cardíaca. Sin embargo, no existe consenso sobre la conducta para la selección de pacientes añosos para este tipo de intervenciones. El objetivo de este estudio fue definir e...

  16. Distribuição configurada pela artéria celíaca em papagaios-verdadeiros (Amazona aestiva

    Directory of Open Access Journals (Sweden)

    E.S Gonçalves

    2011-10-01

    Full Text Available Foram descritas a origem e a distribuição da artéria celíaca em 20 papagaios-verdadeiros (Amazona aestiva, por meio do preenchimento do sistema arterial com solução de látex corado, fixado em solução de formol, para posterior dissecação de seus ramos colaterais. Como primeiro ramo, a artéria célica emitiu a artéria proventricular dorsal, que seguiu para o ventrículo como artéria gástrica dorsal e, em seguida, enviou a artéria proventricular ventral, que em 85% dos exemplares se originou diretamente da artéria celíaca, ou do seu ramo esquerdo em 15%. Em 25% dos casos, a artéria esplênica foi emitida antes da bifurcação em ramo esquerdo e direito. O ramo esquerdo foi responsável pela origem de ramos proventriculares, ramos pilóricos, artéria esplênica e artéria proventricular ventral, a qual emitiu ramos ao proventrículo e ao esôfago. A artéria celíaca também originou as artérias gástrica ventral e gástrica esquerda, que foram responsáveis pela emissão da artéria hepática esquerda. O ramo direito emitiu artérias esplênicas - que variaram de uma a sete -, duodenal - destinada ao segmento mais caudal da alça ascendente do duodeno, hepática direita - para o lobo direito do fígado. Em seu segmento terminal, o ramo direito dividiu-se em artérias gástrica direita - para o ventrículo -, pancreaticoduodenal - para o pâncreas, alças ascendente e descendente do duodeno e segmentos cranial do íleo e caudal do jejuno. A irrigação determinada pela artéria celíaca nos papagaios segue o que é proposto para aves de outros gêneros, apresentando divergências como ausência das artérias vesicular e ileocecal, bem como da vesícula biliar e ceco.

  17. Implementación de un electrocardiógrafo mostrando la señal cardíaca en una computadora gobernada por software libre (python)

    OpenAIRE

    Cirino Morales, Roberto Carlos; Murillo Castro, Ronny Javier; Yapur Auad, Miguel

    2014-01-01

    El electrocardiograma es la mejor manera de observar el comportamiento del corazón humano y registrar la gran variedad de señales eléctricas que ahí se producen. Este proyecto consiste en implementar un circuito de electrocardiografía, y, mediante comunicación USB enviar los datos a una computadora personal. Para esto se creó una aplicación en Python, mediante el cual se procesan los datos y se los convierte en la señal cardíaca en tiempo real. Python que es un lenguaje de programación fácil ...

  18. Utilización de células madre para la regeneración miocárdica en la insuficiencia cardíaca

    OpenAIRE

    Prosper, F. (Felipe); Herreros, J.; Alegria, E. (Eduardo)

    2003-01-01

    La terapia celular en la reparación miocárdica se vislumbra como una de las estrategias terapéuticas con mayor futuro en el tratamiento de la insuficiencia cardíaca. Numerosos estudios in vitro recientes apoyan la potencialidad de distintos tipos de células madre de diferenciarse hacia los tejidos necesarios para regenerar el tejido miocárdico dañado, mientras que estudios en animales de experimentación sugieren que células madre de músculo (mioblastos), médula ósea (p...

  19. ACA微胶囊固定化细胞发酵木糖醇%Xylitol Fermentation Using Cells Microencapsulated by Chitosan-alginate (ACA)

    Institute of Scientific and Technical Information of China (English)

    陈爱政; 万宁

    2002-01-01

    考察了以游离酵母细胞、海藻酸钠固定化细胞、壳聚糖/海藻酸钠(ACA)微胶囊固定化细胞的木糖醇发酵,发现与游离、海藻酸钠固定化发酵相比,微囊化发酵转化率更高、更稳定.其转化率稳定在65%左右,发酵周期约为50 h.

  20. Interleucina 1β correlaciona-se com MIBG e parâmetros do exercício, na insuficiência cardíaca?

    Directory of Open Access Journals (Sweden)

    Leandro Rocha Messias

    2013-05-01

    Full Text Available FUNDAMENTO: Na insuficiência cardíaca, níveis de interleucina 1β (IL 1β se associam a prognóstico. A atividade adrenérgica cardíaca avaliada através da cintilografia com metiodobenzilguanidina (I123 MIBG e parâmetros do exercício são importantes preditores de prognóstico. A relação entre essas variáveis não está bem definida. OBJETIVO: Avaliar associação entre níveis de IL 1β com parâmetros do exercício e do I123 MIBG. MÉTODOS: Estudo observacional transversal, com avaliação de 25 pacientes consecutivos com insuficiência cardíaca e fração de ejeção menor que 45%, através de: dosagem de IL 1β; parâmetros do I123 MIBG [relação coração/mediastino precoce e tardia, taxa de washout (WO]; e teste ergométrico em esteira pelo protocolo de Rampa. RESULTADOS: Separados em dois grupos pelos níveis de IL 1β (normal vs. elevado, o grupo com níveis aumentados apresentava menor reserva de duplo produto (RDP, menor capacidade funcional (CF e recuperação mais lenta da frequência cardíaca no 1º (RFC 1º e 2º minuto (RFC 2º, e maior WO. Na análise univariada, todas as variáveis se correlacionaram com a IL 1β; RDP: r = 0,203, p = 0,024; CF: r = 0,181, p = 0,034; RFC 1º: r = 0,182, p = 0,034; RFC 2º: r = 0,204, p = 0,023; WO: r = 0,263, p = 0,009. Na multivariada, apenas a WO permaneceu com correlação significativa (r2 = 0,263, p = 0,009. CONCLUSÃO: A hipertonia adrenérgica foi o principal determinante dos níveis de IL 1β, demonstrando que a atividade simpática excessiva influencia a atividade inflamatória sistêmica. As variáveis do teste ergométrico não foram capazes de identificar pacientes com níveis elevados de IL 1β.

  1. Acupuntura na assistência de enfermagem ao paciente portador de arritmias cardíacas: pesquisa bibliográfica

    OpenAIRE

    Márcio Rogério Bertuga; Vanessa Pellegrino Toledo

    2012-01-01

    Introdução: Entre as patologias cardíacas, parte dos eventos está relacionada com as arritmias. Inúmeros tratamentos são encontrados; medicamentosos e cirúrgicos; que nem sempre apresentam resultados satisfatórios, com uso de drogas que provocam reações adversas significativas e, a busca pela adequação da dosagem causa grande desconforto. As cirurgias são onerosas e nem sempre acessíveis aos sofredores de arritmias. Atualmente, busca-se por tratamentos alternativos, entre os quais, a Acupuntu...

  2. EFEITO DA BAIXA DISPONIBILIDADE DE CARBOIDRATO NA DIETA SOBRE O PRIMEIRO LIMIAR DE VARIABILIDADE DA FREQUÊNCIA CARDÍACA EM TESTE PROGRESSIVO EM CICLOERGOMÊTRO

    OpenAIRE

    Guilherme Assunção Ferreira; Universidade Federal de Lavras; Michel Cardoso de Angelis Pereira; Universidade Federal de Lavras; Fernando Roberto de Oliveira; Universidade Federal de Lavras

    2012-01-01

    O Objetivo do presente estudo foi analisar o efeito de uma dieta pobre em CHO sobre o primeiro limiar de trasnsição fisiológica (LT1) identificado a partir da análise do comportamento da Variabilidade da Frequência Cardíaca (VFC ) em teste progressivo em ciclo ergometro. Para tanto 9 sujeitos de 18 a 32 foram submetidos a 2 testes em ciclo ergometro com carga inicial de 25 W e incrementos de 25 W a cada dois minuto. O teste foi encerrado quando o indivíduo não acompanhava a rotação determina...

  3. Predicción de Lesión Renal Aguda asociada a Cirugía Cardíaca: la Escala CRATE

    OpenAIRE

    2016-01-01

    La injuria o lesión renal aguda (LRA) es una complicación frecuente en el post-operatorio de cirugía cardíaca y se asocia a un incremento de la morbimortalidad. El diagnostico precoz es fundamental en el abordaje de esta entidad para iniciar tempranamente medidas preventivas. El objetivo de este estudio fue diseñar una escala de predicción postoperatoria de LRA no dialítica, en pacientes con función renal previa normal operados de cirugía cardiaca con circulación extracorpórea....

  4. Comportamento dos quimiorreflexos central e periférico na insuficiência cardíaca Comportamiento de los quimiorreflejos central y periférico en la insuficiencia cardíaca Behavior of central and peripheral chemoreflexes in heart failure

    Directory of Open Access Journals (Sweden)

    Guilherme Veiga Guimarães

    2011-02-01

    Full Text Available A síndrome da insuficiência cardíaca (IC pode ser definida como via final de qualquer forma de doença cardíaca. Os reflexos cardiovasculares simpatoinibitórios como o reflexo arterial barorreceptor estão significativamente suprimidos na IC. Pacientes com IC apresentam maior ventilação para determinada carga de trabalho quando comparados a indivíduos normais. Esse fato gera baixa eficiência ventilatória e relaciona-se com maior ventilação relativa à produção de gás carbônico, que é um preditor de mau prognóstico, além de ser um fator limitante ao exercício. Há evidências de que o desequilíbrio autonômico contribua para a patogênese e a progressão da insuficiência cardíaca. Os quimiorreflexos são os principais mecanismos de controle e regulação das respostas ventilatórias às mudanças de concentração do oxigênio e gás carbônico arterial. A ativação do quimiorreflexo causa aumento da atividade simpática, frequência cardíaca, pressão arterial e volume minuto. No entanto, o aumento do volume minuto e da pressão arterial, pelo feedback negativo provocam inibição da resposta simpática à ativação do quimiorreflexo. Apesar das alterações funcionais dos reflexos, seu comportamento em condições normais e patológicas, especialmente sua contribuição para o estado simpatoexcitatório encontrado na IC, não tem sido amplamente estudado. Dessa forma, esta revisão tem por objetivo integrar os conhecimentos a respeito dos quimiorreflexos central e periférico na síndrome da insuficiência cardíaca, bem como esclarecer a influência da terapêutica medicamentosa da insuficiência cardíaca nos quimiorreflexos.El síndrome de insuficiencia cardíaca (IC puede ser definido como vía final de cualquier forma de enfermedad cardíaca. Los reflejos cardiovasculares simpáticoinhibitorios como el reflejo arterial barorreceptor están significativamente suprimidos en la IC. Pacientes con IC presentan mayor

  5. Finite Element Simulation of Flexible Roll Forming with Supplemented Material Data and the Experimental Verification

    Institute of Scientific and Technical Information of China (English)

    YAN Yu; WANG Haibo; LI Qiang; GUAN Yanzhi

    2016-01-01

    Flexible roll forming is a promising manufacturing method for the production of variable cross section products. Considering the large plastic strain in this forming process which is much larger than that of uniform deformation phase of uniaxial tensile test, the widely adopted method of simulating the forming processes with non-supplemented material data from uniaxial tensile test will certainly lead to large error. To reduce this error, the material data is supplemented based on three constitutive models. Then a finite element model of a six passes flexible roll forming process is established based on the supplemented material data and the original material data from the uniaxial tensile test. The flexible roll forming experiment of a B pillar reinforcing plate is carried out to verify the proposed method. Final cross section shapes of the experimental and the simulated results are compared. It is shown that the simulation calculated with supplemented material data based on Swift model agrees well with the experimental results, while the simulation based on original material data could not predict the actual deformation accurately. The results indicate that this material supplement method is reliable and indispensible, and the simulation model can well reflect the real metal forming process. Detailed analysis of the distribution and history of plastic strain at different positions are performed. A new material data supplement method is proposed to tackle the problem which is ignored in other roll forming simulations, and thus the forming process simulation accuracy can be greatly improved.

  6. Is vitamin C supplementation beneficial?

    DEFF Research Database (Denmark)

    Lykkesfeldt, Jens; Poulsen, Henrik Enghusen

    2010-01-01

    of the benefit:harm ratio of antioxidant supplements. We have examined the literature on vitamin C intervention with the intention of drawing a conclusion on its possible beneficial or deleterious effect on health and the result is discouraging. One of several important issues is that vitamin C uptake is tightly...... controlled, resulting in a wide-ranging bioavailability depending on the current vitamin C status. Lack of proper selection criteria dominates the currently available literature. Thus, while supplementation with vitamin C is likely to be without effect for the majority of the Western population due...... to saturation through their normal diet, there could be a large subpopulation with a potential health problem that remains uninvestigated. The present review discusses the relevance of the available literature on vitamin C supplementation and proposes guidelines for future randomised intervention trials....

  7. Nutritional Supplements for Strength Power Athletes

    Science.gov (United States)

    Wilborn, Colin

    Over the last decade research involving nutritional supplementation and sport performance has increased substantially. Strength and power athletes have specific needs to optimize their performance. Nutritional supplementation cannot be viewed as a replacement for a balanced diet but as an important addition to it. However, diet and supplementation are not mutually exclusive, nor does one depend on the other. Strength and power athletes have four general areas of supplementation needs. First, strength athletes need supplements that have a direct effect on performance. The second group of supplements includes those that promote recovery. The third group comprises the supplements that enhance immune function. The last group of supplements includes those that provide energy or have a direct effect on the workout. This chapter reviews the key supplements needed to optimize the performance and training of the strength athlete.

  8. Strain y strain rate para dummies

    Directory of Open Access Journals (Sweden)

    Pastor Olaya, MD

    2011-11-01

    Full Text Available Desarrollos recientes en el campo de la ecocardiografía han permitido a los cardiólogos cuantificar de manera objetiva la función miocárdica regional y global con base en los conceptos de deformación (strain y velocidad de deformación (strain rate que pueden calcularse de manera no invasiva tanto en el ventrículo izquierdo como en el derecho, y suministrar valiosa información en múltiples escenarios clínicos. Dado que esta técnica novedosa y promisoria se utiliza cada vez más en la clínica y en estudios de investigación, se hace necesario el conocimiento adecuado de sus principios, así como de sus aspectos técnicos, alcances y limitaciones para una mejor implementación. En este artículo se busca dar explicación a los conceptos fundamentales y las potenciales aplicaciones clínicas de la strain y la strain rate derivados por speckle tracking (strain 2D.

  9. Production of Agaricus bisporus on substrates pre-colonized by Scytalidium thermophilum and supplemented at casing with protein-rich supplements.

    Science.gov (United States)

    Coello-Castillo, M M; Sánchez, J E; Royse, D J

    2009-10-01

    The objective of this study was to evaluate performance of Agaricus bisporus (Ab) on substrates pre-colonized by Scytalidiumthermophilum (St), a thermophilic fungus known to enhance yields of Ab and increase selectivity of the substrate. The radial extension rate (RER) of the mycelium of three strains of St and their influence on the growth of a brown strain of Ab were evaluated. We also determined the time required for colonization of pangola grass by St in a compost pile and the influence of three protein-rich supplements on yield of Ab on pangola grass (Digitaria decumbens) colonized by St. RER of St ranged from 10.1mm/d on grass to 18.9 mm/d on potato dextrose yeast extract agar, with significant differences among substrates and among strains. Ab grew faster on substrate colonized for 1, 2, or 3 days by St (RER of 3.31, 3.29, 3.23 mm/d, respectively) compared to non-colonized substrate (1.85 mm/d). Ab was cultivated on substrate samples selected daily from the St-inoculated pile, with biological efficiencies (BE) ranging from 4% (day 0) to 73.9% (day 2). Protein-rich supplements (soybean, black beans and cowpeas) added at casing significantly stimulated mushroom yield on St-colonized substrate compared to the non-supplemented control. BE varied from 26.1% on substrate non-supplemented to 73.1% on compost supplemented with ground soybean. There were no significant differences in mushroom yield observed among supplements evaluated.

  10. Pyridoxine supplementation during isoniazid therapy.

    Science.gov (United States)

    Snider, D E

    1980-12-01

    Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy. In vivo pyridoxine is converted into coenzymes which play an essential role in the metabolism of protein, carbohydrates, fatty acids, and several other substances, including brain amines, INH apparently competitively inhibits the action of pyridoxine in these metabolic functions. The reported frequency of INH-induced neuropathy in various studies is reviewed and population groups at relatively high risk of developing this complication are identified. The routine use of pyridoxine supplementation to prevent peripheral neuropathy in high risk populations is recommended.

  11. 68Ga-NOTA-Aca-BBN(7–14) PET/CT in Healthy Volunteers and Glioma Patients

    Science.gov (United States)

    Zhang, Jingjing; Li, Deling; Lang, Lixin; Zhu, Zhaohui; Wang, Ling; Wu, Peilin; Niu, Gang; Li, Fang; Chen, Xiaoyuan

    2017-01-01

    This work was designed to study the safety, biodistribution, and radiation dosimetry of a gastrin-releasing peptide receptor (GRPR)– targeting, 68Ga-labeled bombesin (BBN) peptide derivative PET tracer, NOTA-Aca-BBN(7–14) (denoted as 68Ga-BBN) in healthy volunteers and to assess the level of receptor expression in glioma patients. Methods Four healthy volunteers (2 male and 2 female) underwent whole-body PET/CT at multiple time points after a bolus injection of 68Ga-BBN (111 ± 148 MBq). Regions of interest were drawn manually over major organs, and time–activity curves were obtained. Dosimetry was calculated using the OLINDA/EXM software. Twelve patients with glioma diagnosed by contrast-enhanced MRI underwent PET/CT at 30–45 min after 68Ga-BBN injection. Within 1 wk afterward, the tumor was surgically removed and immunohistochemical staining of tumor samples against GRPR was performed and correlated with the PET/CT results. Results 68Ga-BBN was well tolerated in all healthy volunteers, with no adverse symptoms being noticed or reported. 68Ga-BBN cleared rapidly from the circulation and was excreted mainly through the kidneys and urinary tract. The total effective dose equivalent and effective dose were 0.0335 ± 0.0079 and 0.0276 ± 0.0066 mSv/MBq, respectively. In glioma patients, all MRI-identified lesions showed high signal intensity on 68Ga-BBN PET/CT. SUVmax and SUVmean were 2.08 ± 0.58 and 1.32 ± 0.37, respectively. With normal brain tissue as background, tumor-to-background ratios were 24.0 ± 8.85 and 13.4 ± 4.54 based on SUVmax and SUVmean, respectively. The immunohistochemical staining confirmed a positive correlation between SUV and GRPR expression level (r2 = 0.71, P < 0.001). Conclusion 68Ga-BBN is a PET tracer with favorable pharmacokinetics and a favorable dosimetry profile. It has the potential to evaluate GRPR expression in glioma patients and guide GRPR-targeted therapy of glioma. PMID:26449838

  12. Fibrose cardíaca associada à intoxicação por Amorimia septentrionalis em bovinos

    Directory of Open Access Journals (Sweden)

    Samuel S.C. Albuquerque

    2014-05-01

    Full Text Available Amorimia septentrionalis contém monofluoracetato de sódio e quando consumida por ruminantes provoca morte súbita. Este estudo teve o objetivo de relatar a epidemiologia, os sinais clínicos e patológicos de surtos de morte súbita em bovinos provocadas por Amorimia septentrionalis nos Estados de Pernambuco e Paraíba. Para isso, realizaram-se visitas técnicas em diversas propriedades nas Microrregiões do Médio Capibaribe/PE e Itabaiana/PB. Oito bovinos foram necropsiados. Coletaram-se tecidos das cavidades abdominal e torácica, além do encéfalo e medula espinhal. As alterações clínicas consistiram em lentidão, decúbito esternal prolongado, relutância em se movimentar quando em estação, cansaço, taquipneia, taquicardia e pulso venoso positivo. Os bovinos que foram forçados a se movimentar apresentaram instabilidade, tremores musculares e queda repentina seguida de vocalizações, movimentos de pedalagem e morte súbita em cerca de 5 a 7 minutos. As principais alterações macroscópicas consistiram em edema pulmonar, coração com aspecto globular com áreas esbranquiçadas, petéquias e equimoses no epicárdio, miocárdio e músculos papilares. À microscopia observou-se aumento da eosinofilia do citoplasma dos cardiomiócitos, núcleos picnóticos, cariorrexia, cariólise, perda das estriações, edema intersticial, infiltrado inflamatório intersticial mononuclear e áreas multifocais de fibrose cardíaca. Nos rins, constatou-se degeneração hidrópico vacuolar e necrose das células epiteliais em túbulos contorcidos. Os sinais clínicos foram semelhantes aos sinais clínicos já descritos em bovinos por plantas que contém MFA. As lesões macro e microscópicas descritas no coração e rins são de grande valor diagnóstico. A. septentrionalis é a principal planta tóxica de interesse pecuário nas microrregiões do Médio Capibaribe e Itabaiana devido às perdas econômicas diretas e indiretas que provoca na pecu

  13. Estudio de la carga interna en pádel amateur mediante la frecuencia cardíaca

    Directory of Open Access Journals (Sweden)

    Jesús Díaz García

    2017-03-01

    Full Text Available Los objetivos de este estudio fueron evaluar el nivel de condición física de 8 sujetos amateur de pádel, definir su perfil energético de esfuerzo en juego real mediante registro de frecuencia cardíaca (FC, y proponer un conjunto de variables justificadas de esta, que permita analizar el perfil de carga interna en pádel. Mediante prueba de esfuerzo incremental máxima en cinta de correr se obtuvieron parámetros ergoespirométricos, respiratorios y sus equivalentes cardíacos, introducidos en el sistema de registro de la FC Polar Team. Los sujetos disputaron 7 partidos de entrenamiento de 1 hora de duración y 72-96 horas de separación entre ellos, obteniéndose como variables: consumo máximo de oxígeno (VO2 máx y porcentaje (% de VO2 máx en el umbral anaeróbico; en prueba de esfuerzo, FC máx., media y mín., y zonas de trabajo metabólicas (rangos de FC. Los resultados presentan VO2 máx de 51,15 ± 5,73 ml · kg–1 · min–1, FC máx. durante el juego de 154,75 ± 7,25 ppm, FC med de 130,0 ± 10,4 ppm para tiempo de juego y 89,75 % del tiempo de juego en zona de trabajo aeróbica. Como conclusión, el esfuerzo al que son sometidos durante el juego a nivel cardiorrespiratorio los jugadores amateur de pádel se basa casi exclusivamente en metabolismos aeróbicos. Además, las variables máx., mín. y media de FC para tiempos de juego y descanso y el establecimiento de zonas de trabajo de FC pueden aportarnos información importante sobre lo que ocurre en el juego a nivel cardiorrespiratorio.

  14. Parada circulatória total em cirurgia cardíaca pediátrica: relato de 130 casos

    Directory of Open Access Journals (Sweden)

    GIFFHORN Hélcio

    1998-01-01

    Full Text Available A hipotermia profunda com parada circulatória total (PCT apresentou um aumento importante nos pacientes operados em nosso Serviço e é de grande utilidade para a correção de alterações cardiovasculares complexas. Estudamos 130 pacientes de janeiro de 1995 a junho de 1996. A idade dos pacientes variou de 2 dias a 16 anos. As doenças mais freqüentes foram o defeito do septo ventricular (DSV (26%, tetralogia de Fallot (TF (13%, transposição das grandes artérias (TGA (10% e defeito do septo atrioventricular (DSAVT (10%. Em todos os pacientes foi usado o oxigenador de membranas, a temperatura retal em PCT foi mantida em média de 15°C. O tempo médio em perfusão foi de 45 minutos e o de PCT de 27 minutos. No pós-operatório imediato, a complicação mais freqüente foi a síndrome de baixo débito (49 casos - 38%. Alterações neurológicas ocorreram em 27 (20% pacientes: 13 (10% convulsões, 8 (6,1% disfunções neuropsicológicas, 5 (3,8% sinais extrapiramidais, 4 (3% déficits neurooftálmicos, 4 (3% comas. Cinco destes sintomas iniciaram precocemente no POI e podem ser atribuídos à PCT (3,8%. Ocorreram 20 (15% óbitos, 3 pacientes apresentaram déficit neurológico na alta hospitalar (2 disartrias - 1 hipertonia muscular. Concluímos que a hipotermia profunda com PCT é útil na correção de anomalias cardíacas complexas e que apresenta baixo risco de complicações neurológicas permanentes. O nosso seguimento tardio é pequeno para avaliar com precisão o desenvolvimento psicomotor dos pacientes.

  15. Prevalência e preditores de embolia pulmonar em pacientes com insuficiência cardíaca agudamente descompensada

    Directory of Open Access Journals (Sweden)

    Luís C. L. Correia

    2012-02-01

    Full Text Available FUNDAMENTO: Não existe descrição da prevalência de Embolia Pulmonar (EP em pacientes internados por quadro clássico de Insuficiência Cardíaca descompensada (IC. OBJETIVO: Em pacientes internados por IC, (1 descrever a prevalência de EP, e (2 avaliar a acurácia diagnóstica dos Escores de Wells e de Genebra. MÉTODOS: Pacientes internados primariamente por IC realizaram sistematicamente cintilografia pulmonar de ventilação/perfusão, sendo EP definida por laudo de alta probabilidade. Para fins de interpretação, definimos baixa probabilidade clínica de EP como prevalência < 5%, de acordo com dados da literatura. No cálculo do tamanho amostral, 49 pacientes seriam necessários para fornecer um intervalo de confiança 95% com ± 10% de precisão, estimando uma prevalência a priori de 15%. RESULTADOS: Em 51 pacientes estudados, seis apresentaram cintilografia de alta probabilidade, resultando em prevalência de 12% (95% IC = 5% - 23%. Os Escores de Wells e de Genebra apresentaram área abaixo da curva ROC de 0,53 (95% IC = 0,27 - 0,80; p = 0,80 e 0,43 (95% IC = 0,13 - 0,73; p = 0,56, respectivamente, indicando ausência de acurácia para o diagnóstico de EP. Alternativamente, variáveis relacionadas à IC mostraram tendência a associação com EP e um modelo exploratório formado por esse tipo de variável apresentou acurácia diagnóstica para EP (ROC = 0,81; 95% IC = 0,66 - 0,96; p = 0,01. CONCLUSÃO: (1 A despeito da ausência de suspeita primária, pacientes internados com IC possuem probabilidade clínica intermediária de EP concomitante; (2 Os escores usualmente utilizados para estimar a probabilidade clínica de EP não se aplicam à população com IC e futuros modelos preditores devem contemplar variáveis relacionadas a esta síndrome.

  16. Three dimensional strained semiconductors

    Energy Technology Data Exchange (ETDEWEB)

    Voss, Lars; Conway, Adam; Nikolic, Rebecca J.; Leao, Cedric Rocha; Shao, Qinghui

    2016-11-08

    In one embodiment, an apparatus includes a three dimensional structure comprising a semiconductor material, and at least one thin film in contact with at least one exterior surface of the three dimensional structure for inducing a strain in the structure, the thin film being characterized as providing at least one of: an induced strain of at least 0.05%, and an induced strain in at least 5% of a volume of the three dimensional structure. In another embodiment, a method includes forming a three dimensional structure comprising a semiconductor material, and depositing at least one thin film on at least one surface of the three dimensional structure for inducing a strain in the structure, the thin film being characterized as providing at least one of: an induced strain of at least 0.05%, and an induced strain in at least 5% of a volume of the structure.

  17. Síndrome poslesión cardíaca. Pericarditis postraumática a propósito de un caso / Post-cardiac injury syndrome. Post-traumatic pericarditis apropos of a case

    OpenAIRE

    Jara Gayán Ordás; Pablo Revilla Martí; Ana Martínez Labuena; Jose A. Linares Vicente; Franciso Roncalés García-Blanco

    2015-01-01

    La pericarditis postraumática se incluye dentro de los síndromes poslesión cardíaca. Este síndrome es un proceso inflamatorio que afecta al pericardio, la pleura, o ambos, secundario a un infarto de miocardio, a un traumatismo torácico o a una cirugía cardíaca. Las características clínicas incluyen el dolor torácico de perfil pericardítico, fiebre y elevación de los reactantes de fase aguda. Generalmente responde de manera satisfactoria al tratamiento con antiinflamatorios no esteroideos y co...

  18. Treinamento físico aeróbio previne à hipertrofia cardíaca patológica e melhora a função diastólica em ratos Zucker obesos

    OpenAIRE

    Barretti, Diego Lopes Mendes; Carmo,Everton Crivoi do; Rosa, Kaleizu Teodoro; Irigoyen, Maria Claudia Costa; Oliveira, Edilamar Menezes

    2011-01-01

    A obesidade é uma patologia diretamente relacionada com o desenvolvimento de doenças cardiovasculares. Por outro lado, o treinamento físico aeróbio atenua o desenvolvimento da obesidade e promove benefícios cardíacos em obesos. Dessa forma, nosso objetivo foi investigar se a obesidade altera a função cardíaca e se sua associação com o treinamento físico aeróbio promove melhora na função cardíaca em ratos Zucker obesos. Os ratos Zucker foram divididos da seguinte forma: grupo magro (GM), grupo...

  19. Fermentation performance of lager yeast in high gravity beer fermentations with different sugar supplementations.

    Science.gov (United States)

    Lei, Hongjie; Xu, Huaide; Feng, Li; Yu, Zhimin; Zhao, Haifeng; Zhao, Mouming

    2016-11-01

    The effects of glucose, sucrose and maltose supplementations on the fermentation performance and stress tolerance of lager yeast (Saccharomyces pastorianus) during high gravity (18°P) and very high gravity (24°P) fermentations were studied. Results showed that throughout 18°P wort fermentation, fermentation performance of lager yeast was significantly improved by glucose or sucrose supplementation, compared with maltose supplementation, especially for sucrose supplementation increasing wort fermentability and ethanol production by 6% and 8%, respectively. However, in the later stage of 24°P wort fermentation, fermentation performance of lager yeast was dramatically improved by maltose supplementation, which increased wort fermentability and ethanol production by 14% and 10%, respectively, compared with sucrose supplementation. Furthermore, higher HSP12 expression level and more intracellular trehalose accumulation in yeast cells were observed by maltose supplementation with increase of the wort gravity from 18°P to 24°P, indicating higher stress response of yeast cells. The excretion of Gly and Ala, and the absorption of Pro in the later stage of fermentation were promoted by maltose supplementation. In addition, with increase of the wort gravity from 18°P to 24°P, higher alcohols level was decreased with maltose supplementation, while esters formation was increased significantly with glucose supplementation. This study suggested that the choice of optimal fermentable sugars maintaining better fermentation performance of lager yeast should be based on not only strain specificity, but also wort gravity. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  20. Strain-engineered MOSFETs

    CERN Document Server

    Maiti, CK

    2012-01-01

    Currently strain engineering is the main technique used to enhance the performance of advanced silicon-based metal-oxide-semiconductor field-effect transistors (MOSFETs). Written from an engineering application standpoint, Strain-Engineered MOSFETs introduces promising strain techniques to fabricate strain-engineered MOSFETs and to methods to assess the applications of these techniques. The book provides the background and physical insight needed to understand new and future developments in the modeling and design of n- and p-MOSFETs at nanoscale. This book focuses on recent developments in st

  1. Biologia de Sistemas Aplicada à Insuficiência Cardíaca com Fração de Ejeção Normal

    Directory of Open Access Journals (Sweden)

    Evandro Tinoco Mesquita

    2014-05-01

    Full Text Available A insuficiência cardíaca com fração de ejeção normal (ICFEN é, atualmente, o fenótipo clínico mais prevalente de insuficiência cardíaca e os tratamentos disponíveis não apresentam redução na mortalidade. Avanços na disciplina de ciências ômicas e em técnicas de elevado processamento de dados empregados na biologia molecular possibilitaram o desenvolvimento de uma abordagem integrativa da ICFEN baseada na biologia de sistemas. O objetivo deste trabalho foi apresentar um modelo da ICFEN baseado na biologia de sistemas utilizando as abordagens bottom-up e top-down. Realizou-se uma pesquisa na literatura de estudos publicados entre 1991-2013 referentes à fisiopatologia da ICFEN, seus biomarcadores e sobre a biologia de sistemas com o desenvolvimento de um modelo conceitual utilizando as abordagens bottom-up e top-down da biologia de sistemas. O emprego da abordagem de biologia de sistemas para ICFEN, a qual é uma síndrome clínica complexa, pode ser útil para melhor entender sua fisiopatologia e descobrir novos alvos terapêuticos.

  2. Aplicabilidade dos resultados de enfermagem em pacientes com insuficiência cardíaca e volume de líquidos excessivo

    Directory of Open Access Journals (Sweden)

    Joelza Celesilvia Chisté Linhares

    Full Text Available RESUMO Objetivo Testar a aplicabilidade clínica da Nursing Outcomes Classification em pacientes com insuficiência cardíaca descompensada e Diagnóstico de Enfermagem Volume de Líquidos Excessivo. Métodos Estudo longitudinal conduzido em duas etapas em um hospital universitário no ano de 2013. Na primeira etapa, utilizou-se a validação por consenso de especialistas para selecionar os resultados de enfermagem e os indicadores relacionados ao diagnóstico de enfermagem; na segunda, foi realizado um estudo longitudinal para avaliação clínica dos pacientes, utilizando-se o instrumento contendo os resultados e indicadores produzidos no consenso. Resultados Foram realizadas avaliações em 17 pacientes. Na avaliação clínica, mensuraram-se os resultados de enfermagem através da avaliação de seus indicadores. Seis resultados apresentaram aumento nos escores, quando comparados às médias da primeira e da última avaliação. A utilização da Nursing Outcomes Classification na prática clínica demonstrou melhora dos pacientes internados por insuficiência cardíaca descompensada. Conclusão A Nursing Outcomes Classification foi sensível às alterações no quadro clínico dos pacientes.

  3. Prevalence of celiac disease in dyspeptic patients Prevalência de doença celíaca em pacientes dispépticos

    Directory of Open Access Journals (Sweden)

    Vinícius Machado de Lima

    2005-09-01

    Full Text Available BACKGROUND: Celiac disease is one of the most common dietary-mediated inflammatory enteropathies that occur in genetically predisposed individuals in response to gluten intolerance. This disorder has become more common than in the past, even if it frequently remains undetected for long periods of time. The screening of patients with dyspepsia, a symptom that can be a manifestation of celiac disease, may allow an early identification of affected individuals. Endoscopy and serological tests may have an important role in the management of these patients. AIMS: Determining the prevalence of celiac disease in dyspeptic patients submitted to routine diagnostic upper gastrointestinal endoscopy. PATIENTS/METHODS: Endoscopic findings, duodenal biopsy histological specimens and serological test results were assessed and compared in 142 patients consecutively admitted with dyspeptic symptoms between October 2001 and October 2003. RESULTS: An endoscopic pattern suggestive of celiac disease was observed in four patients. The IgG-AGA assay was positive in 24 patients. Two of the IgG-AGA positive patients also yielded positive results on the IgA-EMA test and concomitantly disclosed endoscopic pattern and histological features in duodenal biopsy compatible with celiac disease. Abnormal endoscopic findings were notably marked in biopsy proven celiac patients. Therefore, a 1.4% prevalence of celiac disease was observed in this study group. CONCLUSIONS: The high prevalence of celiac among dyspeptic symptomatic individuals indicates that they are a higher risk group for developing celiac disease. Undiagnosed celiac disease may be inferred by endoscopic markers of duodenal villous atrophy. Endoscopic findings, however, may be inadequate to suitably diagnose this disease and consequently the incorporation of diagnostic serologic assays of celiac disease in routine testing for dyspepsia is strongly recommended.RACIONAL: A doença celíaca, uma das mais comuns

  4. Associação entre autocuidado e reinternação hospitalar de pacientes com insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Amanda Chlalup Linn

    2016-06-01

    Full Text Available RESUMO Objetivo: verificar associação entre o autocuidado e o número de reinternações hospitalares de pacientes com diagnóstico de insuficiência cardíaca (IC descompensada, bem como testar a aplicabilidade de dois instrumentos de avaliação de autocuidado. Estudo longitudinal, realizado em um hospital de referência cardiológica do sul do Brasil. Método: foram incluídos 82 pacientes, com idade média de 61,85±12,33 anos, 57,3% do sexo masculino. O escore médio da avaliação de autocuidado encontrado pelas escalas European Heart Failure Self-care Behavior Scale e a Escala de Autocuidado para Pacientes com Insuficiência Cardíaca foi insatisfatório. Resultados: foi verificada uma média de 2,57±1,66 reinternações hospitalares no último ano por descompensação da IC. Houve correlação entre os escores de autocuidado com número de reinternações hospitalares por IC descompensada. Escolaridade e idade mostraram-se associadas ao autocuidado dos pacientes com IC. Conclusão: ambas as escalas avaliam o autocuidado de forma relevante, sendo correlacionados os seus índices.

  5. Diagnóstico de enfermagem de pacientes no período transoperatório de cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Galdeano Luzia Elaine

    2003-01-01

    Full Text Available O objetivo deste estudo foi identificar os diagnósticos de enfermagem de pacientes no período transoperatório de cirurgia cardíaca. Para a coleta de dados, foi elaborado e validado um instrumento baseado no modelo conceitual de Horta. Foram avaliados 17 pacientes adultos, no período transoperatório de cirurgia cardíaca, sendo nove homens e oito mulheres, com idade média de 58 anos. Os diagnósticos de enfermagem, identificados segundo a Taxonomia I da NANDA, com freqüência superior a 50,0%, foram: risco para infecção (100%, risco para desequilíbrio de volume de líquidos (100%, troca de gases prejudicada (100%, risco para aspiração (100%, proteção alterada (100%, integridade da pele prejudicada (100%, risco para disfunção neurovascular periférica (100%, risco para lesão perioperatória de posicionamento (100% e risco para temperatura corporal alterada (94,1%. Observamos uma predominância dos diagnósticos de enfermagem relacionados às necessidades fisiológicas.

  6. Ochratoxin A in brewer's yeast used as food supplement.

    Science.gov (United States)

    Gottschalk, Christoph; Biermaier, Barbara; Gross, Madeleine; Schwaiger, Karin; Gareis, Manfred

    2016-02-01

    Brewer's yeasts are rich in vitamins of the B-group and contain other nutritive factors; therefore, they are recommended as valuable food supplements for people with special dietary requirements like pregnant women, children, and adolescents, or for people with high physical activity. Additionally, certain strains of brewer's yeast are known to be capable of adsorbing xenobiotics such as mycotoxins. Because of that, these yeasts are regarded as having positive effects in food, beverage, and feed technology. Their potential to bind mycotoxins such as ochratoxin A (OTA), however, can subsequently lead to a contamination of such brewer's yeasts used as food supplements. In the present study, we analyzed 46 samples of brewer's yeasts for the occurrence of OTA by HPLC with fluorescence detector (HPLC-FLD) and for confirmatory measurements by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Nearly 90% of the samples were contaminated with OTA, the levels ranging from the limit of detection (LOD, 0.01 μg/kg) to 4.2 μg/kg. The mean and median levels of contamination were 0.49 and 0.27 μg/kg, respectively. Based on these results, the additional weekly OTA exposure by regularly consuming such supplements was assessed. Depending on different subpopulations (adults, children) and levels of contamination used for calculation, the additional OTA intake via brewer's yeast products ranged from 9.3% (mean case) to 114% (worst case) of the published mean weekly OTA intake in Germany (adults 279.3 ng, children 195.3 ng). At present, maximum levels for OTA in nutritional supplements like brewer's yeast do not exist. Based on our results, however, it is recommended that producers of these dietary supplements should include mycotoxin analyses in ongoing and future self-monitoring programs and in product quality checks.

  7. Papel do óxido nítrico no desenvolvimento de lesões cardíacas na fase aguda da infecção experimental pelo Trypanosoma cruzi Role of nitric oxide in the development of cardiac lesions during the acute phase of experimental infection by Trypanosoma cruzi

    Directory of Open Access Journals (Sweden)

    Cláudia Renata Bibiano Borges

    2009-04-01

    Full Text Available A doença de Chagas é causada pelo Trypanosoma cruzi e o coração é o órgão mais acometido. O óxido nítrico apresenta importante ação anti-Trypanosoma, porém, com pouca evidência de seu papel no mecanismo de lesão tecidual. O objetivo deste estudo foi analisar a contribuição do óxido nítrico no desenvolvimento da inflamação e da fibrose cardíaca na fase aguda da infecção experimental por cepas Y e Colombiana do Trypanosoma cruzi. A inflamação foi significativamente maior nos animais infectados pela cepa Colombiana, comparada com os infectados com a cepa Y, tanto nos animais C57BL/6 (3,98x1,87%; p=0,004 quanto nos animais C57BL/6 deficientes na sintase do óxido nítrico induzível (3,99x2,4%; p=0,013. O parasitismo cardíaco dos animais C57BL/6 deficientes na sintase do óxido nítrico induzível infectados pela cepa Colombiana foi significativamente maior que o destes mesmos animais infectados com a cepa Y (2,78x0,17 ninhos/mm²; p=0,004 assim como, os animais C57BL/6 infectados com a cepa Colombiana (2,78x1,33 ninhos/mm²; p=0,006 ou cepa Y (2,78x0,53 ninhos/mm²; p=0,005. Os dados reforçam o papel do óxido nítrico no controle do parasitismo e sugerem seu papel na proteção tecidual, controlando a inflamação e potencialmente diminuindo lesões cardíacas durante a fase aguda na doença de Chagas experimental.Chagas disease is caused by Trypanosoma cruzi and the heart is the organ most affected. Nitric oxide has notable anti-Trypanosoma action, but with little evidence regarding its role in the mechanism for tissue injury. The objective of this study was to analyze the contribution of nitric oxide towards the development of inflammation and cardiac fibrosis during the acute phase of experimental infection by Y and Colombian strains of Trypanosoma cruzi. The inflammation was significantly more intense in animals infected with the Colombian strain, compared with those infected with the Y strain, both in C57BL/6

  8. Herbal Supplements and Sport Performance

    Institute of Scientific and Technical Information of China (English)

    Ellen Coleman; Ron Maughan; Sozanne Nelson Steen; Rob Skinner

    2008-01-01

    @@ KEY POINTS ·Labels on dietary supplements can be misleading. Containers may include substantially more,but usually less,of the listed amounts of ingredients,and substances may be added? some of which can cause failed doping tests for athletes?

  9. A Supplement for Teaching Beowulf

    Science.gov (United States)

    Milosh, Joseph

    1970-01-01

    Suggests supplementing the teaching of "Beowulf" to high school students with (1) translation and grammatical analysis of parts of the original lines, (2) study of Anglo-Saxon poetic techniques, and (3) students' imitation of old English poetic techniques in New English. (SW)

  10. Added Value via SPI supplement

    Science.gov (United States)

    Supplement that indicates where to find the source data sets on the EPA system.This dataset is associated with the following publication:Bowden, J., K.D. Talgo, T. Spero , and C. Nolte. Assessing the Added Value of Dynamical Downscaling Using the Standardized Precipitation Index. ADVANCES IN METEOROLOGY. Hindawi Publishing Corporation, New York, NY, USA, 2016(8432064): 14 pages, (2016).

  11. Supplements to Traditional Vocabulary Teaching

    Institute of Scientific and Technical Information of China (English)

    布亚男

    2012-01-01

      In a word, Vocabulary plays an indispensable part in language proficiency and provides much of the basis of how wel learns language, so it cannot be ignored. I discussed Schools’ viewpoints on the vocabulary teaching ,Reason for forgetting, Traditional approach to vocabulary teaching, supplements to vocabulary teaching,the author hope the above content can offer some hints for language learners.

  12. New supplements to infant formulas.

    Science.gov (United States)

    Eshach Adiv, Orly; Berant, Moshe; Shamir, Raanan

    2004-12-01

    Foods, which, in addition to their nutritional attributes, contain also elements that are considered to be health-promoting, have been termed "functional foods". In this regard, human milk has gained recognition as being the ultimate functional food for infants - by its biological compatibility, nutritional value and the undisputed added value of its health promoting qualities. Intensive research activity has recently evolved in a quest to identify and define the components of human milk that might confer disease-preventing and health-enhancing properties and to determine the instances and clinical conditions in which these factors become particularly important. The outcome of such research would also provide a rationale for advocating the supplementation of commercial infant formulas with such substances. In effect, the body of data accumulated from scientific and clinical studies on nucleotides, probiotics, prebiotics and long-chain polyunsaturated fatty acids in human milk and as additives to infant formula, has become regarded as convincing enough by the infant formula industry so as to launch into the market formulas supplemented with one or more of these factors - in an effort to emulate human milk and its beneficial effects. The following review is intended for the reader to obtain a general idea of the new supplements that have been introduced to infant formulas. We summarize the pertinent experimental and clinical observations concerning each of the supplements, pointing out their potential specific benefits, their possible disadvantages and the issues that still remain unresolved.

  13. Omega-3 Supplements: An Introduction

    Science.gov (United States)

    ... N O P Q R S T U V W X Y Z Omega-3 Supplements: In Depth ... JAMA Internal Medicine . 2014;174(3):460-462. Hooper L, Harrison RA, Summerbell CD, et al. Omega ... on November 2, 2012. Kris-Etherton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, ...

  14. Potassium supplementation and heart rate

    NARCIS (Netherlands)

    Gijsbers, L.; Molenberg, Famke; Bakker, S.J.L.; Geleijnse, J.M.

    2016-01-01

    Background and aims: Increasing the intake of potassium has been shown to lower blood pressure, but whether it also affects heart rate (HR) is largely unknown. We therefore assessed the effect of potassium supplementation on HR in a meta-analysis of randomized controlled trials. Methods and resul

  15. [Susceptibility of Lactobacillus rhamnosus strains isolated from probiotic products to antimicrobial agents].

    Science.gov (United States)

    Wiatrzyk, Aldona; Polak, Maciej; Krysztopa-Grzybowska, Katarzyna; Czajka, Urszula; Lutyńska, Anna

    2015-01-01

    Probiotics Generally Recognized as Safe (GRAS), when given in relevant dose, are able to induce strain-specific beneficial effects for health of humans or animals. L. rhamnosus strains originating from four medicinal products, 2 dietary foods for special medical purposes and dietary supplement, were tested for susceptibility to antibiotics and chemotherapeutics following L. rhamnosus and L.rhamnosus GG strain identity confirmation with use of PCR, rep-PCR and AFLP methods. L. rhamnosus working seeds of medicinal products and isolates originating from dietary foods for special medical purposes or dietary supplement were found correctly classified on the levels of species or L. rhamnosus GG strain identities. Antibiotics and chemotherapeutics susceptibility profiles of L. rhamnosus strains allowed for choice of treatment options in six out of seven products under study.

  16. Cardiac response and anxiety levels in psychopathic murderers Resposta cardíaca e nível de ansiedade em homicidas psicopatas

    Directory of Open Access Journals (Sweden)

    Antonio de Pádua Serafim

    2009-09-01

    Full Text Available OBJECTIVE: To compare the emotional response and level of anxiety of psychopathic murderers, non-psychopathic murderers, and nonpsychopathic non-criminals. METHOD: 110 male individuals aged over 18 years were divided into three groups: psychopathic murderers (n = 38; non-psychopathic murderers (n = 37 serving sentences for murder convictions in Maximum Security Prisons in the State of Sao Paulo; and non-criminal, non-psychopathic individuals (n = 35 according to the Psychopathy Checklist-Revised. The emotional response of subjects was assessed by heart rate variation and anxiety level (State-Trait Anxiety Inventory after viewing standardized pictures depicting pleasant, unpleasant and neutral content from the International Affective Picture System. RESULTS: Psychopathic murderers presented lower anxiety levels and smaller heart rate variations when exposed to pleasant and unpleasant stimuli than nonpsychopathic murderers or non-psychopathic non-criminals. The results also demonstrated that the higher the score for factor 1 on the Psychopathy Checklist-Revised, the lower the heart rate variation and anxiety level. CONCLUSION: The results suggest that psychopathic murderers do not present variation in emotional response to different visual stimuli. Although the non-psychopathic murderers had committed the same type of crime as the psychopathic murderers, the former tended to respond with a higher level of anxiety and heart rate variation.OBJETIVO: Comparar a atividade cardíaca e nível de ansiedade de homicidas psicopatas e não psicopatas e não criminosos não psicopatas. MÉTODO: 110 homens com idade superior a 18 anos, divididos em três grupos: homicidas psicopatas (n = 38, homicidas não psicopatas (n = 37 cumprindo pena por homicídio em Prisões de Segurança Máxima do Estado de São Paulo e não criminosos e não psicopatas (n = 35 de acordo com a Escala de Avaliação de Psicopatia. A resposta emocional foi avaliada pela variação da

  17. Dolor de la articulación sacroilíaca: Anatomía, Diagnóstico y Tratamiento Sacroiliac joint pain: Anatomy, Diagnosis and Treatment

    Directory of Open Access Journals (Sweden)

    G. E. Mejía

    2008-04-01

    Full Text Available El dolor de la articulación sacroilíaca es una causa frecuente de dolor bajo de espalda, sin embargo el diagnóstico de artralgia sacroilíaca no es fácil de confirmar y la exploración física de la articulación es controvertido. Además este diagnóstico a menudo pasa inadvertido para el médico, por lo que la falta de consideración de esta posible causa de lumbalgia da lugar a tratamientos inapropiados e inadecuados. La articulaciones sacroilíacas, sinoviales del tipo anfiartrosico irregular, monoaxiales, en la cual se articulan las carillas articulares del sacro al ilion, Su innervación es cuestión de debate, pero las más recientes investigaciones refieren que deriva de L2-S2, L4-S2, L5-S2. La prevalencia del dolor de la articulación sacroilíaca no esta bien estudiado, hay numerosas etiologías para el dolor de articulación sacroilíaca, estas causas se pueden dividir en intraarticulares y extraarticulares. Para la exploración física se cuenta con una serie de 12 pruebas las cuales fueron emitidas por un comité de expertos y se concluye que encontrar 3 o más pruebas positivas es muy sugestivo de dolor de dicha. El tratamiento se puede dividir en conservador, intervencionista donde se puede utilizar desde la infiltración con anestésico local y esteroide hasta radiofrecuencia y por ultimo quirúrgico para casos seleccionados.The pain of the sacroiliac joint is a frequent cause of low back pain, however the diagnose of sacroiliac artralgia it is not easy to confirm and the physical exploration of the joint is controversial. Also this I often diagnose it happens inadvertent for the physician, for what the lack of consideration of this possible low back pain cause gives place to inappropriate and inadequate treatments. The sacroiliac joint is synovial of the type irregular anphiarthrosic, monoaxial, in which the sides joint are articulated from the sacrum one to the Ilion, Their innervation is debate question, but those but

  18. Consideraciones nutricionales en el paciente con falla cardíaca crónica Nutritional considerations in patients with chronic heart failure

    Directory of Open Access Journals (Sweden)

    Mario A Hernández

    2012-12-01

    Full Text Available La insuficiencia cardíaca congestiva es un síndrome caracterizado por reducción del gasto cardíaco, aumento de las presiones de llenado ventricular y activación neuroendocrina, que lleva a un proceso de fibrosis y apoptosis de la célula cardíaca. Afecta alrededor de 23 millones de personas en el mundo y confiere un pésimo pronóstico una vez se diagnostica. Desde el punto de vista fisiopatológico, la relación entre citocinas pro-inflamatorias, activación neuro-hormonal y alteraciones gastrointestinales conduce a un estado denominado caquexia cardíaca, determinado por pérdida acelerada de peso, fatiga, reducción de la fuerza muscular, anorexia y disminución de la calidad de vida; este proceso es capaz de deteriorar aún más el pronóstico vital de estos pacientes. En las últimas dos décadas, se han realizado avances en el tratamiento farmacológico y eléctrico de la falla cardíaca; sin embargo los estudios en el campo no farmacológico son pocos, en especial en el aspecto nutricional, y así mismo son escasas las recomendaciones de las guías internacionales acerca del tema. En estudios pequeños, una aproximación nutricional ha demostrado impactar de manera positiva la calidad de vida y tolerancia al ejercicio, si bien se requieren grandes estudios para determinar la viabilidad de este abordaje en pacientes con falla cardíaca.Congestive heart failure is a syndrome characterized by reduced cardiac output, increased ventricular filling pressures and neuroendocrine activation, which leads to a process of cardiac cell fibrosis and apoptosis. It affects nearly 23 million people worldwide and once diagnosed has a poor prognosis. From a physiopathological point of view, the relationship between pro-inflammatory cytokines, neurohormonal activation and gastrointestinal disturbances leads to a condition called cardiac cachexia, characterized by accelerated weight loss, fatigue, decreased muscle strength, anorexia and decreased

  19. ACA Federal Upper Limits

    Data.gov (United States)

    U.S. Department of Health & Human Services — Affordable Care Act Federal Upper Limits (FUL) based on the weighted average of the most recently reported monthly average manufacturer price (AMP) for...

  20. Clinical use of glutamine supplementation.

    Science.gov (United States)

    Wernerman, Jan

    2008-10-01

    Endogenous production of glutamine may become insufficient during critical illness. The shortage of glutamine is reflected as a decrease in plasma concentration, which is a prognostic factor for poor outcome in sepsis. Because glutamine is a precursor for nucleotide synthesis, rapidly dividing cells are most likely to suffer from a shortage. Therefore, exogenous glutamine supplementation is necessary. In particular, when i.v. nutrition is given, extra glutamine supplementation becomes critical, because most present formulations for i.v. use do not contain any glutamine for technical reasons. The major part of endogenously produced glutamine comes from skeletal muscle. For patients staying a long time in the intensive care unit (ICU), the muscle mass decreases rapidly, which leaves a tissue of diminishing size to maintain the export of glutamine. The metabolic and nutritional adaptation in long-staying ICU patients is poorly studied and is one of the fields that needs more scientific evidence for clinical recommendations. To date, there is evidence to support the clinical use of glutamine supplementation in critically ill patients, in hematology patients, and in oncology patients. Strong evidence is presently available for i.v. glutamine supplementation to critically ill patients on parenteral nutrition. This must be regarded as the standard of care. For patients on enteral nutrition, more evidence is needed. To guide administration of glutamine, there are good arguments to use measurement of plasma glutamine concentration for guidance. This will give an indication for treatment as well as proper dosing. Most patients will have a normalized plasma glutamine concentration by adding 20-25 g/24 h. Furthermore, there are no reported adverse or negative effects attributable to glutamine supplementation.

  1. COMPARATIVE STUDY OF FOOD SUPPLEMENTS USED ON THE ACTIVITY OF KINETIC ENDURANCE CHARAKTER APPLIED AS A CARDIOVASCULAR DISEASES PREVENTION

    OpenAIRE

    DIČE, Michal

    2009-01-01

    The aim of this thesis is to compare food supplements used on the activity of endurance character and their influence on the cardiovascular system. The teoretical part is pursued to the basic food components and their metabolism and to kinetic activities splitting. The practical part gives information about splitting of sports supplements used on the activity of endurance character, their usage and effects. It deals with the question of human organism behaviour during the strain of endurance ...

  2. Muscle Mass and Weight Gain Nutritional Supplements

    Science.gov (United States)

    Campbell, Bill

    There are numerous sports supplements available that claim to increase lean body mass. However, for these sports supplements to exert any favorable changes in lean body mass, they must influence those factors regulating skeletal muscle hypertrophy (i.e., satellite cell activity, gene transcription, protein translation). If a given sports supplement does favorably influence one of these regulatory factors, the result is a positive net protein balance (in which protein synthesis exceeds protein breakdown). Sports supplement categories aimed at eliciting a positive net protein balance include anabolic hormone enhancers, nutrient timing pre- and postexercise workout supplements, anticatabolic supplements, and nitric oxide boosters. Of all the sports supplements available, only a few have been subject to multiple clinical trials with repeated favorable outcomes relative to increasing lean body mass. This chapter focuses on these supplements and others that have a sound theoretical rationale in relation to increasing lean body mass.

  3. Kommentarer og supplement til DS 418

    DEFF Research Database (Denmark)

    Rode, Carsten; Saxhof, Bjarne

    1999-01-01

    Comments and Supplement for DS 418. Lecture note for DTU course 64040 Basic Course in Building Energy Technology.......Comments and Supplement for DS 418. Lecture note for DTU course 64040 Basic Course in Building Energy Technology....

  4. Probiotic Supplements Failed to Prevent Babies' Infections

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_167008.html Probiotic Supplements Failed to Prevent Babies' Infections Benefits of ... 3, 2017 MONDAY, July 3, 2017 (HealthDay News) -- Probiotic supplements may not protect babies from catching colds ...

  5. 7 CFR 1710.110 - Supplemental financing.

    Science.gov (United States)

    2010-01-01

    ... supplemental financing according to their plant revenue ratio (PRR), as defined in § 1710.2, based on the most recent year-end data available on the date of loan approval, as follows: PRR Supplemental loan...

  6. Kommentarer og supplement til DS 418

    DEFF Research Database (Denmark)

    Rode, Carsten; Saxhof, Bjarne

    1999-01-01

    Comments and Supplement for DS 418. Lecture note for DTU course 64040 Basic Course in Building Energy Technology.......Comments and Supplement for DS 418. Lecture note for DTU course 64040 Basic Course in Building Energy Technology....

  7. Anthocyanin analyses of Vaccinium fruit dietary supplements

    Science.gov (United States)

    Vaccinium fruit ingredients within dietary supplements were identified by comparisons with anthocyanin analyses of known Vaccinium profiles (demonstration of anthocyanin fingerprinting). Available Vaccinium supplements were purchased and analyzed; their anthocyanin profiles (based on HPLC separation...

  8. Multidimensional evaluation of the elderly undergoing cardiac surgery Evaluación multidimensional de ancianos sometidos a cirugía cardíaca Avaliação multidimensional de idosos submetidos à cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Marinez Kellermann Armendaris

    2012-01-01

    salud, así como también, remite a la necesidad de un abordaje integral en salud que refleje en mejora de su calidad de vida.OBJETIVO: Conhecer aspectos multidimensionais do idoso submetido à cirurgia cardíaca. MÉTODOS: Estudo epidemiológico descritivo, realizado no Instituto de Cardiologia do Distrito Federal-IC/DF. Utilizou-se para a coleta de dados instrumento contendo as variáveis: sócio demográficas, clínicas, scores de avaliação da função cognitiva,capacidade funcional e emocional. Testes do Qui-quadrado e T de Student foram empregados para a análise dos dados. RESULTADOS: Da população total, 64% era do sexo feminino; Idosos não alfabetizados e com formação mínima, somados, representavam 80%.Dislipidemia, e Hipertensão arterial sistólica, foram às doenças crônicas mais prevalentes. Mais de 50% dos idosos apresentaram alterações cognitivas e afetivas, e algum grau de dependência funcional. CONCLUSÃO: Esses resultados apontam para a complexidade do idoso no que se refere á sua condição de saúde, bem como, remete a necessidade de uma abordagem integral em saúde que reflita em melhora de sua qualidade de vida.

  9. Direct Summands of ⊕-Supplemented Modules

    Institute of Scientific and Technical Information of China (English)

    Nil Orhan; Derya Keskin Tütüncü; Rachid Tribak

    2007-01-01

    A module M is called ⊕-supplemented if every submodule of M has a supplement that is a direct summand of M. It is shown that if M is a ⊕-supplemented module and r(M) is a coclosed submodule of M for a left preradical r, then r(M) is a direct summand of M, and both r(M) and M/r(M) are ⊕-supplemented.

  10. Sprains and Strains

    Science.gov (United States)

    ... and chronic. An acute strain occurs when a muscle becomes strained or pulled — or may even tear — when it stretches unusually far or abruptly. Acute ... and increases joint range of motion, making the muscles less tight and less prone to trauma ... Environmental conditions. Slippery or uneven surfaces can make ...

  11. Highly Strained Organophosphorus Compounds

    NARCIS (Netherlands)

    Slootweg, J.C.

    2005-01-01

    In our research on small, strained organophosphorus ring systems we became interested in the synthesis and applications of species that are even more strained than the parent phosphirane, by introducing an exocyclic double bond (methylenephosphirane), and by cyclopropyl spirofusion to the edge (e.g

  12. THE EFFECT OF DIFFERENT PROBIOTIC STRAINS ON FATTENINTHE EFFECT OF DIFFERENT PROBIOTIC STRAINS ON F

    Directory of Open Access Journals (Sweden)

    Cyril Hrnčár

    2013-02-01

    Full Text Available The aim of this work was to verify the effect of different probiotic strains applied through a drinking water source to fattening and carcass parameters of broiler ducks. Fattening experiment was realised in half-operating conditions of experimental basis of Department of Poultry Science and Small Animal Husbandry in three-floor cage technology. Totally 90 broiler duck were divided to three groups. Experimental group 1 (n=30 received probiotic strain Lactobacillus fermentum CCM 7158 with concentration of 1x109 colony forming units (CFU in drinking water daily addition of 0.90 g day 1 to day 56 of fattening. Experimental group 2 (n=30 received probiotic strain Enterococcus faecium M 74 with concentration of 1x109 colony forming units (CFU in drinking water daily addition of 0.45 g day 1 to day 56 of fattening. The control group of birds (n=30 received water without any probiotics. The supplementation of probiotic strains Lactobacillus fermentum and Enterococcus faecium no significant affected (P≥0.05 final body weight, feed consumption and mortality of broiler ducks. From carcass parameters, we recorded statistically significant (P<0.05 reduction in weight of abdominal fat of broiler ducks for application of tested probiotic strains.

  13. 76 FR 20354 - Notice of Intent To Award Supplemental Affordable Care Act Funding

    Science.gov (United States)

    2011-04-12

    ...-1001, ``APHL--CDC Partnership for Quality Laboratory Practice'' cooperative agreement. AGENCY: Centers... published version of Funding Opportunity CDC-RFA-HM10-1001. Award Information: Type of Award: Cooperative... President signed into law the Affordable Care Act (ACA), Public Law 111-148. ACA is designed to improve...

  14. Environment driven cereulide production by emetic strains of Bacillus cereus.

    Science.gov (United States)

    Apetroaie-Constantin, Camelia; Shaheen, Ranad; Andrup, Lars; Smidt, Lasse; Rita, Hannu; Salkinoja-Salonen, Mirja

    2008-09-30

    The impacts of growth media and temperature on production of cereulide, the emetic toxin of Bacillus cereus, were measured for seven well characterised strains selected for diversity of biochemical and genetic properties and sources of origin. All strains carried cereulide synthase gene, ces, on a megaplasmid of ca. 200 kb and all grew up to 48-50 degrees C, but produced cereulide only up to 39 degrees C. On tryptic soy agar five strains, originating from foods, food poisonings and environment, produced highest amounts of cereulide at 23 to 28 degrees C, whereas two strains, from human faeces, produced cereulide similarly from 23 to 39 degrees C, with no clear temperature trend. These two strains differed from the others also by producing more cereulide on tryptic soy agar if supplemented with 5 vol.% of blood, whereas the other five strains produced similarly, independent on the presence of blood. On oatmeal agar only one strain produced major amounts of cereulide. On skim milk agar, raw milk agar, and MacConkey agar most strains grew well but produced only low amounts of cereulide. Three media components, the ratio [K+]:[Na+], contents of glycine and [Na+], appeared of significance for predicting cereulide production. Increase of [K+]:[Na+] (focal variable) predicted (P cereus in a complex manner. The relevance of the findings to production of cereulide in the gut and to the safety of amino acids as additives in foods containing live toxinogenic organisms is discussed.

  15. Identification of Bacillus strains for biological control of catfish pathogens.

    Science.gov (United States)

    Ran, Chao; Carrias, Abel; Williams, Malachi A; Capps, Nancy; Dan, Bui C T; Newton, Joseph C; Kloepper, Joseph W; Ooi, Ei L; Browdy, Craig L; Terhune, Jeffery S; Liles, Mark R

    2012-01-01

    Bacillus strains isolated from soil or channel catfish intestine were screened for their antagonism against Edwardsiella ictaluri and Aeromonas hydrophila, the causative agents of enteric septicemia of catfish (ESC) and motile aeromonad septicaemia (MAS), respectively. Twenty one strains were selected and their antagonistic activity against other aquatic pathogens was also tested. Each of the top 21 strains expressed antagonistic activity against multiple aquatic bacterial pathogens including Edwardsiella tarda, Streptococcus iniae, Yersinia ruckeri, Flavobacterium columnare, and/or the oomycete Saprolegnia ferax. Survival of the 21 Bacillus strains in the intestine of catfish was determined as Bacillus CFU/g of intestinal tissue of catfish after feeding Bacillus spore-supplemented feed for seven days followed by normal feed for three days. Five Bacillus strains that showed good antimicrobial activity and intestinal survival were incorporated into feed in spore form at a dose of 8×10(7) CFU/g and fed to channel catfish for 14 days before they were challenged by E. ictaluri in replicate. Two Bacillus subtilis strains conferred significant benefit in reducing catfish mortality (Pbiological control in vivo was also investigated in terms of whether the strains contain plasmids or express resistance to clinically important antibiotics. The Bacillus strains identified from this study have good potential to mediate disease control as probiotic feed additives for catfish aquaculture.

  16. 40 CFR 141.809 - Supplemental treatment.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Supplemental treatment. 141.809... treatment. (a) Any supplemental drinking water treatment units installed onboard existing or new aircraft... the manufacturer's plans and specifications and FAA requirements. (b) Water supplemental treatment...

  17. 14 CFR 91.211 - Supplemental oxygen.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Supplemental oxygen. 91.211 Section 91.211... Requirements § 91.211 Supplemental oxygen. (a) General. No person may operate a civil aircraft of U.S. registry... the required minimum flight crew is provided with and uses supplemental oxygen for that part of...

  18. 43 CFR 7.32 - Supplemental definitions.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Supplemental definitions. 7.32 Section 7... RESOURCES Department of the Interior Supplemental Regulations § 7.32 Supplemental definitions. For purposes of this subpart, the following definitions will be used: (a) Site of religious or cultural...

  19. [Trade of food supplement: food or drug supplement?

    Science.gov (United States)

    Siracusa, Margherita; Petrelli, Fabio

    2016-09-01

    The aporia is obvious: food supplement, classified and regulated by food law, sometimes have the characteristics and the typical effects of medicines. In addition, these are produced by pharmaceutical companies and, through the scientific officer, are prescribed by doctors and dispensed by pharmacies. This study will attempt to retrace the winding, and sometimes overlapping, regulatory pathways of the legislation on food supplement, food and medicines. It will be important object the particular application of the precautionary principle behind the legislation on food supplement: application "in posterior", so the controls on the purity of the product and the possible effects resulting from the assumption is carried out ex post trade. So we try to disentangle the intricate legislation with the national (and European) Court contributions. In particular, after a brief analysis of the rulings of the Competition and Market Authority on misleading advertising and by the Supreme Court in relation to crimes against health damage, it will come to the analysis of interpretative problems of a purely criminal law nature, in light of the recent proposal for reform about agribusiness crimes. Finally, it will be inevitable to analyze briefly the recent implementation of the d.lgs. n. 17/2004 concerning the distance trade of non-prescription medicines. There is no doubt that now, internet represents the preferred distribution channel for pharmaceutical products (including food supplement) and the most tempting "place" (because of control difficulties) for the realization of criminal conduct. The conclusion will be that the need to achieve more targeted and homogeneous regulatory measures, while also having to protect - public and individual - health through the protection of the legal security in one with the protection of the right to information.

  20. Strain y strain rate para dummies Strain and strain rate for dummies

    Directory of Open Access Journals (Sweden)

    Pastor Olaya

    2011-12-01

    Full Text Available Desarrollos recientes en el campo de la ecocardiografía han permitido a los cardiólogos cuantificar de manera objetiva la función miocárdica regional y global con base en los conceptos de deformación (strain y velocidad de deformación (strain rate que pueden calcularse de manera no invasiva tanto en el ventrículo izquierdo como en el derecho, y suministrar valiosa información en múltiples escenarios clínicos. Dado que esta técnica novedosa y promisoria se utiliza cada vez más en la clínica y en estudios de investigación, se hace necesario el conocimiento adecuado de sus principios, así como de sus aspectos técnicos, alcances y limitaciones para una mejor implementación. En este artículo se busca dar explicación a los conceptos fundamentales y las potenciales aplicaciones clínicas de la strain y la strain rate derivados por speckle tracking (strain 2D.Recent developments in the field of echocardiography have allowed cardiologists to objectively quantify regional and global myocardial function based on the deformation (strain and strain rate which can be calculated non-invasively in both the left or right ventricle, and provide valuable information in multiple clinical settings. Since this new technique is promising and is being increasingly used in clinical and research studies, the adequate knowledge of its principles and its technical aspects, scope and limitations are necessary for its better implementation. This article seeks to explain fundamental concepts and potential clinical applications of strain and strain rate derived by speckle tracking (2D strain.

  1. Evaluation of congruence among dietary supplement use and motivation for supplementation in young, Canadian athletes.

    Science.gov (United States)

    Parnell, Jill A; Wiens, Kristin; Erdman, Kelly Anne

    2015-01-01

    Dietary supplement use is endemic in young athletes; however, it is unclear if their choices are congruent with their motivation for supplementation and the established benefits of the dietary supplements. The aim of this study was to evaluate the relationships between dietary supplement use and self-reported rationale in young athletes. Canadian athletes (n = 567; 11-25 years; 76% club or provincial level, 24% national or higher) completed a questionnaire designed to assess supplementation patterns and motivation for supplementation. Chi square tests examined associations between dietary supplements and self-reported rationale for use. Vitamin and mineral supplements, including vitamin-enriched water, were associated with several health- and performance- related reasons (p sport bars, sport gels, etc.). Plant extracts and fatty acids were primarily associated with health reasons, particularly immune support (p motivators for supplementation. Educational interventions are essential to ensure young athletes are using dietary supplements safely and effectively.

  2. Diuréticos melhoram a capacidade funcional em pacientes com insuficiência cardíaca congestiva

    Directory of Open Access Journals (Sweden)

    Eterno Francesca Tadeu

    1998-01-01

    Full Text Available OBJETIVO: Quantificar a influência do diurético na capacidade funcional em portadores de insuficiência cardíaca congestiva (ICC descompensada, através do teste de caminhada. MÉTODOS: Estudamos 10 pacientes internados, com idade média de 47 anos, sendo cinco do sexo masculino, com ICC descompensada, em classe funcional III e IV (NYHA, submetidos ao teste de caminhada de 6 e 9min na admissão e alta. Foram obtidos registros na admissão e alta, do peso, do ecocardiograma, sódio, potássio, uréia, creatinina séricos, hematócrito e hemoglobina. O tratamento instituído foi o aumento da dose prévia de furosemida EV e/ou VO, associado ou não a diurético tiazídico, tendo sido mantidas as doses prévias de digital, captopril ou da associação de nitrato e hidralazina. RESULTADOS: O período de compensação variou entre 4 a 30 dias (média 8,7±7,8 dias. Ao ecocardiograma bidimensional apresentaram diâmetro do ventrículo esquerdo que variou de 47 a 81mm e a fração de ejeção de 0,26 a 0,74. A distância caminhada em 6min passou de 193,4±71,5m para 341,8±67,7m (p<0,00002 e em 9min passou de 268,1±119,6m para 518,0±114,8m (p<0,00005 . Não houve diferença estatística entre os valores, na admissão e alta, do hematócrito, hemoglobina, uréia, creatinina e sódio. O potássio sérico médio à admissão era de 4,0±0,91mEq/l e na alta 4,69±1,00mEq/l (p= 0,01 e o peso dos pacientes na admissão e na alta foi de 58,9±6,42kg para 52,9±5,31kg, respectivamente (p<0,0006 . CONCLUSÃO: A compensação da ICC com o uso de diurético induziu a uma melhora importante, a curto prazo, da capacidade física dos pacientes, demonstrada pelo aumento da distância caminhada em 6 e 9min. O diurético melhorou significativamente o desempenho físico.

  3. Deficiência de ferro na insuficiência cardíaca Iron deficiency in heart failure patients

    Directory of Open Access Journals (Sweden)

    Antonio Carlos P. Barretto

    2010-06-01

    Full Text Available A anemia é uma comorbidade frequente nos pacientes com insuficiência cardíaca (IC e sua presença parece estar associada à pior evolução, sendo descrita em alguns estudos como fator de prognóstico independente tanto na IC sistólica quanto na diastólica. Entretanto, ainda não sabemos se a anemia causa pior evolução ou se é apenas um marcador do maior comprometimento cardíaco nos portadores de IC. A etiologia da anemia na IC é multifatorial e parece variar conforme a população estudada. Os fatores como a deficiência nutricional de ferro, presença de insuficiência renal, intensa atividade inflamatória sistêmica, uso de medicações que inibem a produção de eritropoetina ou que causam perda sanguínea são os mais frequentes causadores de anemia na IC. A prevalência de anemia citada nos estudos de IC é muito variável (de 9% a 79,1% e isto é dependente da população estudada, da fase da cardiopatia, do método e referências hematimétricas utilizadas para diagnóstico. A deficiência de ferro é um importante fator etiológico e está presente em um número significativo de pacientes com anemia e IC associada. Em estudo realizado em nosso grupo, a incidência de deficiência de ferro nos pacientes com anemia foi de 61,8%. Portanto, a anemia é um achado frequente, sua presença acentua as manifestações clínicas da IC e está associada a piora do prognóstico. Conhecer a causa da anemia facilita o seu tratamento e, apesar da sua correção ainda não ser consenso, os pacientes sem anemia têm melhor evolução.Anemia is common in heart failure (HF patients with its presence apparently associated to a worse prognosis, and as such is described in some studies as an independent predictor of death and hospitalization of patients suffering from systolic and diastolic dysfunction. It remains unknown whether anemia causes the worse evolution of HF patients or whether it is only one marker of a worse heart disease stage. The

  4. Avaliando a atividade vagal cardíaca na eletrocardiografia convencional Evaluating cardiac vagal activity on a conventional electrocardiogram

    Directory of Open Access Journals (Sweden)

    Flávia P. Teixeira

    2007-04-01

    Full Text Available OBJETIVO: Determinar a viabilidade da utilização de traçado convencional de eletrocardiografia (ECG para avaliação da atividade vagal cardíaca (AVC. MÉTODOS: Foram analisados, retrospectivamente, 1.395 indivíduos (995 homens, na faixa de idade de 46 + 17,2 anos (média ± desvio padrão, com traçados de ECG convencional para medida do Delta RR, que representa a diferença, em ms, entre o maior e o menor intervalo RR, e com resultados da avaliação autonômica parassimpática, o teste de exercício de quatro segundos (T4s, que quantifica a AVC por meio do índice vagal cardíaco (IVC. Foram obtidas curvas ROC para determinar os valores de Delta RR com melhor relação entre sensibilidade e especificidade para os pontos de corte de baixa e alta AVC, respectivamente, de 1,20 e 1,95. RESULTADOS: Os valores de delta RR correlacionaram-se significativamente com os de IVC (r = 0,40; p 120 ms como os melhores pontos de corte para baixa e alta AVC, com sensibilidade de 75% e 57%, especificidade de 62% e 79% e áreas das curvas ROC de 0,76 e 0,74, respectivamente. CONCLUSÃO: A medida visual do delta RR em um traçado de ECG parece ser válida para a avaliação clínica preliminar e rápida da AVC, podendo ser útil em consultórios, emergências ou situações nas quais o uso de métodos mais sofisticados de avaliação autonômica não seja viável, oportuno ou conveniente.OBJECTIVE: To determine the viability of using a conventional electrocardiogram (ECG tracing for assessment of CVA. METHODS: We retrospectively analyzed 1395 individuals (995 males, aged 46 ± 17.2 years (mean ± standard deviation with conventional ECG tracings to measure the delta RR (which represents the difference in milliseconds (ms between the greatest and smallest RR interval and results of a second autonomic parasympathetic evaluation, the 4-second exercise test (T4s, that quantifies CVA by the cardiac vagal index (CVI. ROC curves were obtained to determine the

  5. Synthetic androgens as designer supplements.

    Science.gov (United States)

    Joseph, Jan Felix; Parr, Maria Kristina

    2015-01-01

    Anabolic androgenic steroids (AAS) are some of the most common performance enhancing drugs (PED) among society. Despite the broad spectrum of adverse effects and legal consequences, AAS are illicitly marketed and distributed in many countries. To circumvent existing laws, the chemical structure of AAS is modified and these designer steroids are sold as nutritional supplements mainly over the Internet. Several side effects are linked with AAS abuse. Only little is known about the pharmacological effects and metabolism of unapproved steroids due to the absence of clinical studies. The large number of designer steroid findings in dietary supplements and the detection of new compounds combined with legal loopholes for their distribution in many countries show that stricter regulations and better information policy are needed.

  6. Weakly Distributive Modules. Applications to Supplement Submodules

    Indian Academy of Sciences (India)

    Engin Büyükaşik; Yilmaz M Demirci

    2010-11-01

    In this paper, we define and study weakly distributive modules as a proper generalization of distributive modules. We prove that, weakly distributive supplemented modules are amply supplemented. In a weakly distributive supplemented module every submodule has a unique coclosure. This generalizes a result of Ganesan and Vanaja. We prove that -projective duo modules, in particular commutative rings, are weakly distributive. Using this result we obtain that in a commutative ring supplements are unique. This generalizes a result of Camillo and Lima. We also prove that any weakly distributive $\\oplus$-supplemented module is quasi-discrete.

  7. 231. Cirugía cardíaca en adultos con cardiopatías congénitas: ¿qué pacientes y patologías intervenimos actualmente?

    Directory of Open Access Journals (Sweden)

    E.C. Ruiz-Solano

    2012-04-01

    Conclusiones: La cirugía congénita sobre pacientes adultos representa una actividad de relevancia en la cirugía cardíaca de hoy día. Nuestros resultados evidencian que este tipo de intervenciones se puede llevar a cabo con una baja morbimortalidad.

  8. Bases moleculares de la hipertrofia cardíaca fisiológica en un modelo de ratón sometido a entrenamiento por natación

    OpenAIRE

    Burgos, Juan Ignacio; Yeves, Alejandra M.; Medina, Andrés J.; Portiansky, Enrique Leo; Barrena, Jorge Pablo; Ennis, Irene L.; Vila Petroff, Martín Gerardo

    2014-01-01

    La adaptación del corazón al ejercicio aeróbico crónico incluye el desarrollo de hipertrofia cardíaca (HC) fisiológica y el mejoramiento de la función contráctil. Los mecanismos subcelulares involucrados en este proceso aún no han sido completamente dilucidados.

  9. Synthetic Androgens as Designer Supplements

    OpenAIRE

    Joseph, Jan Felix; Parr, Maria Kristina

    2015-01-01

    Anabolic androgenic steroids (AAS) are some of the most common performance enhancing drugs (PED) among society. Despite the broad spectrum of adverse effects and legal consequences, AAS are illicitly marketed and distributed in many countries. To circumvent existing laws, the chemical structure of AAS is modified and these designer steroids are sold as nutritional supplements mainly over the Internet. Several side effects are linked with AAS abuse. Only little is known about the pharmacologic...

  10. Particle Suspension Mechanisms - Supplemental Material

    Energy Technology Data Exchange (ETDEWEB)

    Dillon, M B

    2011-03-03

    This supplemental material provides a brief introduction to particle suspension mechanisms that cause exfoliated skin cells to become and remain airborne. The material presented here provides additional context to the primary manuscript and serves as background for designing possible future studies to assess the impact of skin cells as a source of infectious aerosols. This introduction is not intended to be comprehensive and interested readers are encouraged to consult the references cited.

  11. Vitamin D Supplementation in Submariners

    Science.gov (United States)

    2008-12-02

    also known as cholecalciferol . This is a result of the reaction between 7-dehydrocholesterol in the epidermis and ultraviolet radiation in the...skin) (From Diet) Vitamin D3 ( Cholecalciferol ) UV light Vitamin D2 (Ergocalciferol) Liver 25-Hydroxy Vitamin D (Calcidiol) Kidney 1,25-Dihydroxy...monthly oral vitamin D3 ( cholecalciferol ) supplementation on fractures and mortality in men and women living in the community: randomized double

  12. Validação da versão brasileira do questionário de ansiedade cardíaca

    Directory of Open Access Journals (Sweden)

    Aline Sardinha

    2013-12-01

    Full Text Available FUNDAMENTOS: A ansiedade cardíaca (AC é o medo de sensações cardíacas, caracterizado por sintomas recorrentes de ansiedade em pacientes com ou sem doença cardiovascular. O Questionário de Ansiedade Cardíaca (QAC é uma ferramenta para avaliar a AC, já adaptado, mas não validado em português. OBJETIVO: Este trabalho apresenta as três fases dos estudos de validação do QAC brasileiro. MÉTODOS: Foram recrutados 98 pacientes com doença arterial coronária, a fim de extrair a estrutura fatorial e avaliar a confiabilidade do QAC (fase 1. O objetivo da fase 2 foi explorar a validade convergente e divergente. Cinquenta e seis pacientes completaram o QAC, juntamente com o Escala de sensações corporais (ESC e o Versão brasileira do Social Phobia Inventory (SPIN. Para determinar a validade discriminante (fase 3, comparamos os escores do QAC de dois subgrupos formados por pacientes da fase 1 (n = 98, de acordo com os diagnósticos de transtorno do pânico e agorafobia obtidos com o MINI - Mini International Neuropsychiatric Interview (Mini Entrevista Neuropsiquiátrica Internacional. RESULTADOS: A solução de dois fatores foi a mais interpretável (46,4% da variância. As subescalas foram denominadas de "Medo e Hipervigilância" (n = 9; alfa = 0,88 e "Evitação" (n = 5; alfa = 0,82. Foi encontrada correlação significativa do fator 1 com o escore total do ESC (p < 0,01, mas não com o fator 2. Os fatores do SPIN apresentaram correlações significativas com as subescalas do QAC (p < 0,01. Na fase 3, os escores dos pacientes "Cardíacos com pânico" foram significativamente maiores no fator 1 do QAC (t = -3,42; p < 0,01, IC = -1,02 a -0,27, e maiores, mas não significativamente diferentes, no fator 2 (t = -1,98; p = 0,51, IC = -0.87 a 0,00. CONCLUSÕES: Os presentes resultados fornecem uma versão final brasileira validada do QAC adequada aos contextos clínicos e de pesquisa.

  13. Ativação adrenérgica alterada se associa à recuperação anormal da Frequência Cardíaca?

    Directory of Open Access Journals (Sweden)

    Leandro Rocha Messias

    Full Text Available FUNDAMENTO: Frequência Cardíaca de Recuperação (RFC reflete a capacidade do sistema cardiovascular de reverter a supressão vagal ocasionada pelo exercício. A cintilografia com metaiodobenzilguanidina (I¹²³ MIBG avalia a inervação e ativação adrenérgica cardíaca. A associação entre esses dois métodos não está bem esclarecida. OBJETIVO: Avaliar associação entre RFC e Taxa de "Washout" (WO de I¹²³ MIBG em pacientes com Insuficiência Cardíaca (IC. MÉTODOS: Vinte e cinco pacientes com fração de ejeção 27%. Para análise estatística, foi utilizado teste U de Mann Whitney e o coeficiente de correlação de Spearman. RESULTADOS: G2 demonstrou uma variação mais lenta da RFC: 1º minuto: G1: 21,5 (16,12 - 26,87 vs G2: 11,00 (8,5 - 13,5 bpm, p = 0,001; 2º minuto: G1: 34 (29 - 39 vs G2: 20 (14 - 26 bpm, p = 0,001; 3º minuto: G1: 46 (37,8 - 54,1 vs G2: 30 (22 - 38 bpm, p = 0,005; 5º minuto: G1: 51,5 (42 - 61 vs G2: 39 (31,5 - 46,5 bpm, p = 0,013; e no 8º minuto: G1: 54,5 (46,5 - 62,5 vs G2: 43 (34 - 52 bpm, p = 0,037. A RFC no 1º (r = -0,555; p = 0,004, e 2º minuto (r = -0,550; p = 0,004 apresentaram correlação negativa com WO. CONCLUSÃO: Pacientes com IC e WO elevado apresentaram uma RFC anormal em comparação com pacientes com WO normal. Tais achados sugerem que a ativação adrenérgica pode influenciar na RFC.

  14. Comparative study of two box H/ACA ribonucleoprotein pseudouridine-synthases: relation between conformational dynamics of the guide RNA, enzyme assembly and activity.

    Directory of Open Access Journals (Sweden)

    Jean-Baptiste Fourmann

    Full Text Available Multiple RNA-guided pseudouridine synthases, H/ACA ribonucleoprotein particles (RNPs which contain a guide RNA and four proteins, catalyze site-specific post-transcriptional isomerization of uridines into pseudouridines in substrate RNAs. In archaeal particles, the guide small RNA (sRNA is anchored by the pseudouridine synthase aCBF5 and the ribosomal protein L7Ae. Protein aNOP10 interacts with both aCBF5 and L7Ae. The fourth protein, aGAR1, interacts with aCBF5 and enhances catalytic efficiency. Here, we compared the features of two H/ACA sRNAs, Pab21 and Pab91, from Pyrococcus abyssi. We found that aCBF5 binds much more weakly to Pab91 than to Pab21. Surprisingly, the Pab91 sRNP exhibits a higher catalytic efficiency than the Pab21 sRNP. We thus investigated the molecular basis of the differential efficiencies observed for the assembly and catalytic activity of the two enzymes. For this, we compared profiles of the extent of lead-induced cleavages in these sRNAs during a stepwise reconstitution of the sRNPs, and analyzed the impact of the absence of the aNOP10-L7Ae interaction. Such probing experiments indicated that the sRNAs undergo a series of conformational changes upon RNP assembly. These changes were also evaluated directly by circular dichroism (CD spectroscopy, a tool highly adapted to analyzing RNA conformational dynamics. In addition, our results reveal that the conformation of helix P1 formed at the base of the H/ACA sRNAs is optimized in Pab21 for efficient aCBF5 binding and RNP assembly. Moreover, P1 swapping improved the assembly of the Pab91 sRNP. Nonetheless, efficient aCBF5 binding probably also relies on the pseudouridylation pocket which is not optimized for high activity in the case of Pab21.

  15. Comparative study of two box H/ACA ribonucleoprotein pseudouridine-synthases: relation between conformational dynamics of the guide RNA, enzyme assembly and activity.

    Science.gov (United States)

    Fourmann, Jean-Baptiste; Tillault, Anne-Sophie; Blaud, Magali; Leclerc, Fabrice; Branlant, Christiane; Charpentier, Bruno

    2013-01-01

    Multiple RNA-guided pseudouridine synthases, H/ACA ribonucleoprotein particles (RNPs) which contain a guide RNA and four proteins, catalyze site-specific post-transcriptional isomerization of uridines into pseudouridines in substrate RNAs. In archaeal particles, the guide small RNA (sRNA) is anchored by the pseudouridine synthase aCBF5 and the ribosomal protein L7Ae. Protein aNOP10 interacts with both aCBF5 and L7Ae. The fourth protein, aGAR1, interacts with aCBF5 and enhances catalytic efficiency. Here, we compared the features of two H/ACA sRNAs, Pab21 and Pab91, from Pyrococcus abyssi. We found that aCBF5 binds much more weakly to Pab91 than to Pab21. Surprisingly, the Pab91 sRNP exhibits a higher catalytic efficiency than the Pab21 sRNP. We thus investigated the molecular basis of the differential efficiencies observed for the assembly and catalytic activity of the two enzymes. For this, we compared profiles of the extent of lead-induced cleavages in these sRNAs during a stepwise reconstitution of the sRNPs, and analyzed the impact of the absence of the aNOP10-L7Ae interaction. Such probing experiments indicated that the sRNAs undergo a series of conformational changes upon RNP assembly. These changes were also evaluated directly by circular dichroism (CD) spectroscopy, a tool highly adapted to analyzing RNA conformational dynamics. In addition, our results reveal that the conformation of helix P1 formed at the base of the H/ACA sRNAs is optimized in Pab21 for efficient aCBF5 binding and RNP assembly. Moreover, P1 swapping improved the assembly of the Pab91 sRNP. Nonetheless, efficient aCBF5 binding probably also relies on the pseudouridylation pocket which is not optimized for high activity in the case of Pab21.

  16. Uso da radiofrequência bipolar para o tratamento da fibrilação atrial durante cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Leonardo Secchin Canale

    2011-06-01

    Full Text Available FUNDAMENTO: O tratamento da fibrilação atrial com dispositivo de ablação de tecidos por radiofrequência bipolar em concomitância à cirurgia cardíaca tem se mostrado método eficaz no tratamento desta arritmia. OBJETIVO: Descrever a experiência inicial do Instituto Nacional de Cardiologia no tratamento cirúrgico da fibrilação atrial com uso de dispositivo de radiofrequência bipolar em pacientes submetidos à cirurgia cardíaca, relatando o resultado de acompanhamento pós-operatório de um ano. MÉTODOS: Entre janeiro de 2008 e março de 2009, 47 pacientes (36 mulheres consecutivos, com idade média de 53,7 ± 10,6 anos, apresentando fibrilação atrial por um período médio de 34,6 meses (3 a 192 meses foram submetidos à ablação cirúrgica desta arritmia, por radiofrequência bipolar, durante o procedimento que motivou a indicação da cirurgia. Oito apresentavam fibrilação atrial intermitente e 39, contínua. Oitenta e um por cento foram submetidos à cirurgia valvar como procedimento principal. Esta é uma análise retrospectiva, observacional, com avaliação de um ano de pós-operatório das variáveis clínicas e de Holter 24 h. RESULTADOS: Dos 47 pacientes, 40 sobreviveram um ano. Desses, 33 foram submetidos a Holter 24 h, em um intervalo médio de 401 dias após a cirurgia. Encontrou-se a seguinte distribuição de ritmos: 24 (73% sinusal, 5 (15% fibrilação atrial, três (9% Flutter atrial e um (3% ritmo juncional. Foram observados dois acidentes vasculares encefálicos, sendo um associado à arritmia supraventricular. CONCLUSÃO: A ablação cirúrgica de fibrilação atrial com dispositivo de radiofrequência bipolar concomitante à cirurgia cardíaca é método eficaz para o tratamento desta arritmia.

  17. Hiperpotassemia na vigência de espironolactona em pacientes com insuficiência cardíaca descompensada Hyperkalemia during spironolactone use in patients with decompensated heart failure

    Directory of Open Access Journals (Sweden)

    Marcelo Villaça Lima

    2008-09-01

    Full Text Available FUNDAMENTO: A incidência de hiperpotassemia relacionada à espironolactona é baixa na insuficiência cardíaca estável, entretanto não foi estudada durante a descompensação. OBJETIVO: Avaliar a influência da espironolactona na insuficiência cardíaca descompensada sobre o potássio sérico. MÉTODOS: Em um estudo de coorte, selecionamos pacientes hospitalizados por descompensação da insuficiência cardíaca, FEVE 6,0 mEq/l e uso de poliestireno de cálcio. Realizou-se a análise multivariada pela regressão logística, e p 60,5 mg/dl, durante a internação, apresenta risco relativo de 9,6 (IC 95% 8,03 - 11,20; p = 0,005 para a ocorrência de hiperpotassemia. CONCLUSÃO: A incidência de hiperpotassemia foi duas vezes maior com espironolactona, mas não estatisticamente significante. Elevação da uréia foi associada à hiperpotassemia. Estudos randomizados são necessários para esclarecer o assunto.BACKGROUND: The incidence of hyperkalemia related to spironolactone use is low in stable heart failure; however, it has not been studied during decompensation. OBJECTIVE: To evaluate the influence of spironolactone on serum potassium in decompensated heart failure (HF. METHODS: In a cohort study, patients that had been hospitalized due to decompensated HF, with left ventricular ejection fraction (LVEF 6.0 mEq/l and the use of calcium polystyrene. A multivariate analysis through logistic regression was carried out and values of p 60.5 mg/dl during the hospitalization presents a relative risk of 9.6 (95%CI 8.03 - 11.20; p = 0.005 for the occurrence of hyperkalemia. CONCLUSION: The incidence of hyperkalemia was two-fold higher with spironolactone use, but it was not statistically significant. The increase in urea levels was associated to the hyperkalemia. Randomized studies are necessary to clarify this issue.

  18. Avaliação da endotelização de hastes de stents em artérias ilíacas de coelhos

    Directory of Open Access Journals (Sweden)

    Celso Kiyochi Takimura

    Full Text Available FUNDAMENTO: A rápida endotelização pós-implante de stent é ocorrência desejável por teoricamente reduzir a possibilidade de trombose do stent. OBJETIVO: Avaliar a extensão da endotelização de hastes de stents eluidores de sirolimus (liberados da face luminal e abluminal e abluminal exclusivamente em artérias ilíacas de coelhos. MÉTODOS: Foram implantados em artérias ilíacas de 10 coelhos quatro stents eluidores de sirolimus na face luminal e abluminal, três stents eluidores de sirolimus na face abluminal, seis stents recobertos com polímero e quatro stents sem recobrimento. Após quatro semanas, foi realizada eutanásia e utilizou-se microscopia eletrônica de varredura para quantificação da área de hastes de stent exposta e da porcentagem de endotelização. RESULTADOS: A área (média ± DP (mm² de hastes expostas de stent sem recobrimento, stent recoberto com polímero, stent eluidor de sirolimus na face luminal e abluminal e stent eluidor de sirolimus na face abluminal foi de 0,12 ± 0,08; 0,09 ± 0,12; 0,60 ± 0,67 e 0,05 ± 0,04 respectivamente (p = 0,120. A porcentagem de endotelização (média ± DP (% de stent sem recobrimento, stent recoberto com polímero, stent eluidor de sirolimus na face luminal e abluminal e stent eluidor de sirolimus na face abluminal foi de 99 ± 01; 99 ± 0; 97 ± 03 e 99 ± 0 respectivamente (p = 0,133. CONCLUSÃO: Após quatro semanas de implante em artérias ilíacas de coelhos, os stents com liberação de sirolimus tanto da face luminal e abluminal quanto da face abluminal exclusivamente apresentaram taxas de endotelização de hastes de stent semelhantes aos apresentados nos demais tipos de stents sem eluição de medicamento.

  19. Comparação de critérios diagnósticos de insuficiência renal aguda em cirurgia cardíaca

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    Márcio Campos Sampaio

    2013-07-01

    Full Text Available FUNDAMENTO: Há grande controvérsia quanto ao diagnóstico de Insuficiência Renal Aguda (IRA, existindo mais de 30 diferentes definições. OBJETIVO: Avaliar a incidência e os fatores de risco para desenvolvimento de IRA no pós-operatório de cirurgia cardíaca de acordo com os critérios RIFLE, AKIN e KDIGO, e comparar o poder prognóstico desses critérios. MÉTODOS: Estudo de corte transversal que incluiu 321 pacientes (62 [53 - 71] anos, 140 homens consecutivamente submetidos a cirurgia cardíaca entre junho de 2011 e janeiro de 2012. Os pacientes foram acompanhados por 30 dias, com vistas ao desenvolvimento de um desfecho composto (mortalidade, necessidade de diálise e internação prolongada. RESULTADOS: A incidência de IRA variou de 15% - 51%, conforme o critério diagnóstico adotado. Enquanto a idade se associou ao risco de IRA nos três critérios, houve variação nos demais determinantes. Durante o acompanhamento, 89 pacientes apresentaram o desfecho e todos os critérios se associaram ao risco aumentado na análise Cox univariada e após o ajuste para idade, sexo, diabetes e tipo de cirurgia. Contudo, após novo ajuste para tempo de circulação extracorpórea e presença de baixo débito cardíaco, apenas o diagnóstico de IRA pelo critério KDIGO manteve esta associação significativa (HR= 1,89 [95% IC: 1,18 - 3,06]. CONCLUSÕES: A incidência e os fatores de risco para IRA pós-cirurgia cardíaca têm grande variação de acordo com os critérios diagnósticos utilizados. Em nossa análise, o critério KDIGO se mostrou superior ao AKIN e ao RIFLE quanto ao seu poder prognóstico.

  20. Experiência inicial e pioneira do implante de valva aórtica transcateter (Inovare por via femoral ou ilíaca

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    José Carlos Dorsa Vieira Pontes

    2013-06-01

    Full Text Available OBJETIVO: O presente trabalho tem por objetivo demonstrar a experiência inicial e pioneira do implante da prótese Inovare pela via transfemoral ou ilíaca. MÉTODOS: Seis pacientes foram submetidos ao implante valvar aórtico transcateter. A via de acesso foi femoral ou ilíaca, por onde foi inserido o dispositivo de entrega, que consiste em um cateter balão de látex com a prótese "crimpada" sobre o mesmo. Com auxílio de introdutor femoral da marca Gore® DrySeal 24 Fr, posicionava-se uma guia extrarrígida com a ponta atraumática no ventrículo esquerdo, passando-se pelo anel valvar. Após valvuloplastia com cateter balão nos casos de estenose valvar nativa, implante da prótese foi realizado após hipotensão induzida por taquicardia controlada por marcapasso temporário. O posicionamento da valva foi orientado por ecocardiograma transesofágico (ETE e radioscopia, objetivando posicionar um terço da extensão da prótese para dentro da cavidade ventricular esquerda. RESULTADOS: O implante valvar com sucesso foi possível nos 6 casos. Não houve necessidade de conversão para cirurgia convencional por impossibilidade de acesso ou migração da prótese. Não houve mortalidade intraoperatória ou hospitalar. Houve redução significativa do gradiente médio pré-operatório de 66,84115,46 mmHg para 19,74110,61 mmHg, no pós-operatório (P=0,002, significando redução de 70,46%. CONCLUSÃO: A prótese Inovare, implantada por via femoral ou ilíaca, foi factível do ponto de vista técnico, apresentando adequado desempenho hemodinâmico no seguimento pós-operatório e não apresentando mortalidade nesta pequena casuística.