WorldWideScience

Sample records for abortion spontaneous

  1. Pregnancy outcome following spontaneous abortions

    Swati Agrawal

    2015-12-01

    Conclusions: Previous history of spontaneous abortion is associated with adverse pregnancy outcome. There is increased risk of abortion, preterm delivery, need for caesarean sections and fetal loss in cases of previous spontaneous abortions. These complications and fetal loss can be reduced by booking the patients and giving due antenatal care. [Int J Reprod Contracept Obstet Gynecol 2015; 4(6.000: 1891-1893

  2. Association between Nutritional Status with Spontaneous Abortion

    Ahmadi, Rahimeh; Ziaei, Saeideh; Parsay, Sosan

    2016-01-01

    Background Spontaneous abortion is the most common adverse pregnancy outcome. We aimed to investigate a possible link between nutrient deficiencies and the risk of spontaneous abortion. Materials and Methods This case-control study included the case group (n=331) experiencing a spontaneous abortion before 14 weeks of pregnancy and the control group (n=331) who were healthy pregnant women over 14 weeks of pregnancy. The participants filled out Food Frequency Questionnaire (FFQ), in which they ...

  3. Association between Nutritional Status with Spontaneous Abortion

    Rahimeh Ahmadi; Saeideh Ziaei; Sosan Parsay

    2016-01-01

    Background: Spontaneous abortion is the most common adverse pregnancy outcome. We aimed to investigate a possible link between nutrient deficiencies and the risk of spontaneous abortion. Materials and Methods: This case-control study included the case group (n=331) experiencing a spontaneous abortion before 14 weeks of pregnancy and the control group (n=331) who were healthy pregnant women over 14 weeks of pregnancy. The participants filled out Food Frequency Questionnaire (...

  4. Early pregnancy angiogenic markers and spontaneous abortion

    Andersen, Louise B; Dechend, Ralf; Karumanchi, S Ananth

    2016-01-01

    BACKGROUND: Spontaneous abortion is the most commonly observed adverse pregnancy outcome. The angiogenic factors soluble Fms-like kinase 1 and placental growth factor are critical for normal pregnancy and may be associated to spontaneous abortion. OBJECTIVE: We investigated the association between...... maternal serum concentrations of soluble Fms-like kinase 1 and placental growth factor, and subsequent spontaneous abortion. STUDY DESIGN: In the prospective observational Odense Child Cohort, 1676 pregnant women donated serum in early pregnancy, gestational week ..., interquartile range 71-103). Concentrations of soluble Fms-like kinase 1 and placental growth factor were determined with novel automated assays. Spontaneous abortion was defined as complete or incomplete spontaneous abortion, missed abortion, or blighted ovum

  5. Spontaneous abortion and physical strain around implantation

    Hjøllund, Niels Henrik Ingvar; Jensen, T.K.; Bonde, J.P.

    2000-01-01

    Existing studies of physical strain and spontaneous abortion are mainly retrospective or based only on pregnancies that have survived the first trimester. Furthermore, almost all studies have relied on averaged measures of physical strain, which tend to blur an effect if peak values during short...... pregnancy the women recorded physical strain prospectively in a structured diary. Physical strain around the time of implantation was associated with later spontaneous abortion. The adjusted risk ratio for women who reported physical strain higher than average at day 6 to 9 after the estimated date...

  6. Socioeconomic position and the risk of spontaneous abortion

    Norsker, Filippa Nyboe; Espenhain, Laura; A Rogvi, Sofie

    2012-01-01

    To investigate the relationship between different indicators of socioeconomic position and the risk of spontaneous abortion.......To investigate the relationship between different indicators of socioeconomic position and the risk of spontaneous abortion....

  7. Analysis of the Spontaneous Abortion in Chinese Married Women

    高尔生; 邓新清; 何更生; 方可娟; 唐威; 楼超华

    1994-01-01

    The spontaneous abortion is a common type of pregnant outcomes. The spontaneous abortion rate can be used to indicate the women's fecundity and the level of the reproductive health. It is also a sensitive indicator for determing the social, economic, and health status and prenatal care. To explore the preventive method for spontaneous abortion and improve women's health level, it is important to evaluate the status of spontaneous abortion and to determine the factors affecting

  8. Association between Nutritional Status with Spontaneous Abortion

    Rahimeh Ahmadi

    2016-11-01

    Full Text Available Background: Spontaneous abortion is the most common adverse pregnancy outcome. We aimed to investigate a possible link between nutrient deficiencies and the risk of spontaneous abortion. Materials and Methods: This case-control study included the case group (n=331 experiencing a spontaneous abortion before 14 weeks of pregnancy and the control group (n=331 who were healthy pregnant women over 14 weeks of pregnancy. The participants filled out Food Frequency Questionnaire (FFQ, in which they reported their frequency of consumption for a given serving of each food item during the past three months, on a daily, weekly or monthly basis. The reported frequency for each food item was converted to a daily intake. Then, consumption of nutrients was compared between the two groups. Results: There are significant differences between the two groups regarding consumed servings/day of vegetables, bread and cereal, meat, poultry, fish, eggs, beans, fats, oils and dairy products (P=0.012, P<0.001, P=0.004, P<0.001, P=0.019, respectively. There are significant differences between the two groups in all micronutrient including folic acid, iron, vitamin C, vitamin B6, vitamin B12 and zinc (P<0.001. Conclusion: Poor nutrientions may be correlated with increased risk of spontaneous abortion

  9. Spontaneous abortion and physical strain around implantation

    Hjollund, N H; Jensen, Tina Kold; Bonde, Jens Peter

    2000-01-01

    pregnancy the women recorded physical strain prospectively in a structured diary. Physical strain around the time of implantation was associated with later spontaneous abortion. The adjusted risk ratio for women who reported physical strain higher than average at day 6 to 9 after the estimated date...

  10. Basal body temperature recordings in spontaneous abortion.

    Cohen, J; Iffy, L; Keyser, H H

    1976-01-01

    Basal body temperature (BBT) charts taken during the cycle of conception in cases that resulted in spontaneous abortion appear to provide the best available information concerning events associated with time of fertilization in doomed gestations. This study is based on a series of 227 patients who had early spontaneous abortion occurring between January 1967 and December 1974. A diagnosis of pregnancy initiated regular assays of urinary estrogen and pregnanediol excretion. Patients were instructed to report any bleeding episode which might occur, and to preserve all tissues that might be expelled. A total of 11 basal body temperature charts were obtained from patients who had subsequent early spontaneous abortion. Chromosome studies and histologic investigations were conducted. Another group of 11 consecutive BBT records were obtained from patients who had normal deliveries. The study shows that women with normal cycles experience a midcycle temperature rise requiring 1 to 3 days. In subsequent patients, this time limit was exceeded in 7 out of 11 cases of early abortion, and in 4 of 11 fertilization that resulted in an apparently normal gestation and infant. As temperature rise resulted from vigorous progesterone secretion by the corpus luteum, subnormal levels indicate inadequate steroidogenesis in the early luteal phase, and falling estrogen and progesterone levels predicted fetal demise in all cases. These findings are useful in the management of early pregnancy that follows repeated spontaneous first trimester abortions or a prolonged period of infertility. They also confirm experimental and clinical evidence regarding the role of ovulation defects in the occurrence of various types of reproductive wastage, including early abortion, anatomic and chromosome defects of the embryo and others. Prospective studies of cycles of conception through BBT recordings/hormone assays may shed light in the understanding of defects of human reproduction.

  11. ANTISPERM ANTIBODY IS A POSSIBLE CAUSE OF SPONTANEOUS ABORTION

    XUChong; CHENFu; LIULi; ZHAOFei-Sha

    1989-01-01

    To clarify the possible correlation between antisperm antibodies (ASA) and spontaneous abortion, 68 women, aged 23-37, experienced 2-9 times of spontaneous abortion were tested for ASA by ELISA. 38 fertile women, aged 24-40, without history of abortion were employed as control.

  12. Maternal smoking predicts the risk of spontaneous abortion

    Nielsen, Ann; Hannibal, Charlotte Gerd; Lindekilde, Bodil Eriksen

    2006-01-01

    BACKGROUND: Few studies have examined smoking prior to pregnancy and the occurrence of spontaneous abortion, as most studies have addressed the risk of spontaneous abortion in relation to smoking during pregnancy. However, results are not entirely consistent. The aim of the present study...... was to assess the risk of spontaneous abortion considering smoking prior to pregnancy. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11,088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n=343......) or who gave birth (n=1,578) during follow-up were selected. Associations between self-reported smoking at enrollment and subsequent spontaneous abortion were analyzed by means of multiple logistic regression. RESULTS: The risk of spontaneous abortion in relation to pre-pregnancy smoking showed a clear...

  13. Maternal underweight and the risk of spontaneous abortion

    Helgstrand, Stine; Andersen, Anne-Marie Nybo

    2005-01-01

    BACKGROUND: To evaluate the risk of spontaneous abortion in relation to maternal pre-pregnant underweight. METHODS: The study was designed as a cohort study within the framework of the Danish National Birth Cohort (DNBC). The participants were a total of 23 821 women recruited consecutively...... spontaneous abortion. Relative risk of spontaneous abortion was calculated as Hazard Ratios using Cox regression with delayed entry. RESULTS: The outcome measure was spontaneous abortion. The hazard ratio for spontaneous abortion in women with a pre-pregnant body mass index (BMI) below 18.5 was 1.24 (95......% confidence limits 0.95-1.63) compared to women with pre-pregnant BMI 18.5-24.9. Women with a BMI of 25 or more had a smaller increase in risk of spontaneous abortion. Adjustment for maternal age, parity, previous miscarriages, and lifestyle factors did not affect the estimates substantially, neither did...

  14. Shared risk aversion in spontaneous and induced abortion

    Catalano, Ralph; Bruckner, Tim A.; Karasek, Deborah

    2016-01-01

    STUDY QUESTION: Does the incidence of spontaneous abortion correlate positively over conception cohorts with the incidence of non-clinically indicated induced abortion as predicted by shared risk aversion? SUMMARY ANSWER: We find that the number of spontaneous and non-clinically indicated induced...... abortions correlates in conception cohorts, suggesting that risk aversion affects both the conscious and non-conscious mechanisms that control parturition. WHAT IS KNOWN ALREADY: Much literature speculates that natural selection conserved risk aversion because the trait enhanced Darwinian fitness. Risk...... and spontaneous abortion over time. STUDY DESIGN, SIZE, DURATION: Using data from Denmark, we test the hypothesis that monthly conception cohorts yielding unexpectedly many non-clinically indicated induced abortions also yield unexpectedly many spontaneous abortions. The 180 month test period (January 1995...

  15. Q-feber som årsag til spontan abort

    Nielsen, Stine Yde; Mølbak, Kåre; Hjøllund, Niels Henrik

    2011-01-01

    Q-fever is a zoonotic infection. Pregnant women constitute a specific risk group as the infection may cause spontaneous abortion, intrauterine death, growth retardation, oligohydramnios and premature birth. A 39 year-old veterinarian had a spontaneous abortion in pregnancy week seven. During...

  16. Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion

    Rasch, Vibeke

    2003-01-01

    OBJECTIVE: To study the association between cigarette, alcohol, and caffeine consumption and the occurrence of spontaneous abortion. METHODS: The study population consisted of 330 women with spontaneous abortion and 1168 pregnant women receiving antenatal care. A case-control design was utilized......; cases were defined as women with a spontaneous abortion in gestational week 6-16 and controls as women with a live fetus in gestational week 6-16. The variables studied comprise age, parity, occupational situation, cigarette, alcohol, and caffeine consumption. The association between cigarette, alcohol......, and caffeine consumption was studied using logistic regression analyzes while controlling for confounding variables. In addition stratified analyzes of the association between caffeine consumption and spontaneous abortion on the basis of cigarette and alcohol consumption were performed. RESULTS: Women who had...

  17. Cytogenetic analysis in 61 couples with spontaneous abortions

    江静; 傅曼芬; 王德芬

    2001-01-01

    Objective To examine the relationship between spontaneous abortion and chromosomal abnormalities. Methods Couples who had one or more consecutive spontaneous abortions and had normal genitals were enrolled for cytogenetic karyotype analysis. Results In the 61 couples, the detected incidence was 11.5%, with five Robertsonian translocations, one reciprocal translocation, and one pericentric inversion of chromosome 7. Conclusion Chromosomal abnormalities may play an important role in fetal wastage.

  18. Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion

    Rasch, Vibeke

    2003-01-01

    given birth twice or more previously had increased odds ratio (OR), 1.78 (1.27-2.49), whereas women who were students had decreased OR, 0.55 (0.34-0.91) for having spontaneous abortions. Regarding lifestyle factors, the adjusted ORs among women who consumed 5 units or more alcohol per week or 375 mg...... units alcohol per week and 375 mg or more caffeine per day during pregnancy may increase the risk of spontaneous abortion....

  19. Acute and post-traumatic stress disorder after spontaneous abortion.

    Bowles, S V; James, L C; Solursh, D S; Yancey, M K; Epperly, T D; Folen, R A; Masone, M

    2000-03-15

    When a spontaneous abortion is followed by complicated bereavement, the primary care physician may not consider the diagnosis of acute stress disorder or post-traumatic stress disorder. The major difference between these two conditions is that, in acute stress disorder, symptoms such as dissociation, reliving the trauma, avoiding stimuli associated with the trauma and increased arousal are present for at least two days but not longer than four weeks. When the symptoms persist beyond four weeks, the patient may have post-traumatic stress disorder. The symptoms of distress response after spontaneous abortion include psychologic, physical, cognitive and behavioral effects; however, patients with distress response after spontaneous abortion often do not meet the criteria for acute or post-traumatic stress disorder. After spontaneous abortion, as many as 10 percent of women may have acute stress disorder and up to 1 percent may have post-traumatic stress disorder. Critical incident stress debriefing, which may be administered by trained family physicians or mental health practitioners, may help patients who are having a stress disorder after a spontaneous abortion.

  20. Expression of AIF-1 and RANTES in Unexplained Spontaneous Abortion and Possible Association with Alloimmune Abortion

    Yong-hong LI; Hai-lin WANG; Ya-juan ZHANG

    2007-01-01

    Objective To investigate the effects of allograft inflammatory factor-1(AIF-1)and (RANTES) in sera and deciduas on unexplained early spontaneous abortion.Methods AIF-1 and RANTES were examined in sera and deciduas/endometria of 43 unexplained early spontaneous abortion women (group A),40 healthy women with early pregnancy(group B)and 20 healthy women with no pregnancy (group C). Immunohistochemistry and enzyme linked immunosorbent assay (ELISA) were used in this study. Results AIF-1 protein was expressed both in deciduas of group A and in endometria of group C.In group A, H scores in the recurrent abortion deciduas specimens were significantly greater than those in the first abortion;in endometrium,expression of AIF-1 was greater in the secretory than in proliferative phase of group C.In group B,concentrations of RANTES in sera were higher in 7th-8th week of pregnancy than in 6th-7th and >8th week of pregnancy;expression of AIF-1 protein showed a negative correlation with RASNTES concentration;a significant increase of the RANTES levels in sera and tissue was observed in group B. Conclusion These results demonstrate, for the first time,that AIF-1 are expressed in deciduas of unexplained spontaneous abortion suggesting that AIF-1 involve in alloimmune abortion; RANTES might act as a novel blocking antibody;AIF-1 and RANTES might act as reliable markers for diagnosis of early alloimmune abortion.

  1. Alcohol consumption at the time of conception and spontaneous abortion

    Henriksen, Tine Brink; Hjollund, Niels Henrik; Jensen, Tina Kold

    2004-01-01

    The authors studied the association between female and male alcohol intakes at the time of conception and the risk of spontaneous abortion, including early pregnancy loss detected by urinary human chorionic gonadotropin. After a nationwide mailing to about 50,000 members of four trade unions....... Women collected morning urine for 10 days from the first day of vaginal bleeding in each cycle. The authors detected 186 pregnancies: 131 resulted in childbirth, and 55 resulted in spontaneous abortion (34 detected by urinary human chorionic gonadotropin). Depending on the intake in the cycle...... of conception and the adjustment factors, female alcohol intake was associated with 2-3 times the adjusted risk of spontaneous abortion compared with no intake, and male alcohol intake was associated with 2-5 times the adjusted risk. Only the adjusted relative risks for 10 or more drinks/week compared...

  2. Association Study of Estrogen Receptor Alpha Gene Polymorphisms with Spontaneous Abortion: Is This a Possible Reason for Unexplained Spontaneous Abortion?

    Negin Anousha

    2013-01-01

    Full Text Available Estrogen plays a crucial role in fetal and placental development through estrogen receptors. Association of estrogen receptor alpha gene (ESR1 polymorphisms with spontaneous abortion has been shown in some studies. Our main goal was to study the potential association of spontaneous abortion with the ESR1 gene variations (PvuII and XbaI in fetal tissue. Totally, 161 samples were recruited including 80 samples of formalin-fixed paraffin-embedded fetal tissue from spontaneous abortion and 81 samples of normal term placental tissue. The restriction fragment length polymorphism (RFLP method was performed for genotyping the rs2234693 (A/G XbaI and rs9340799 (T/C PvuII single nucleotide polymorphisms located in intron 1 of ESR1. The results have been confirmed by DNA sequencing analysis. The different genotypes distribution was detected in two study groups. Haplotype analysis indicated that ppxx is protective genotype against spontaneous abortion (P = 0.01. In conclusion, the potential role of ESR1 genetic variation in spontaneous abortion might be valuable in high-risk subjects, and that needs to be confirmed with future studies.

  3. Spontaneous Abortion and a Diet Drug Containing Caffeine and Ephedrine

    Howards, Penelope P; Hertz-Picciotto, Irva; Bech, Bodil H

    2012-01-01

    BACKGROUND: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth...

  4. Recurrent Spontaneous Abortions- An Update on Diagnosis and Management

    Pildner von Steinburg S

    2009-01-01

    Full Text Available Recurrent spontaneous abortions (RSA, defined as three or more consecutive miscarriages, affect 1 % of couples trying to conceive. Risk of abortion is 15 % in every pregnancy, increasing with the number of previous miscarriages. While 50–70 % of sporadic abortions are attributed to chromosomal defects, mostly trisomies, in RSA there are different underlying disorders of uterine, genetic, infectious, endocrine, immune or thrombophilic etiology, but about 25–40 % are of still unknown etiology. While specific therapy for uterine, infectious, and endocrine disorders may be applied, treatment options for some immunologic and thrombophilic disturbances are still under examination. Careful counseling must be offered to patients with RSA of unknown etiology, as not all treatment options widely offered are based on sufficient evidence yet.

  5. SEROPREVALENCE OF TOXOPLASMA GONDII IN SPONTANEOUS ABORTIONS IN PREGNANT WOMEN

    Anubhuti

    2015-05-01

    Full Text Available INTRODUCTION: Toxoplasmosis is one of the diseases comprising the TORCH [ Toxoplasma gondii , Rubella virus , Cytomegalovirus , Herpes simplex virus] infections . It is known to cause perinatal death if the organism is acquired during pregnancy . Toxoplasmosis during pregnancy can cause congenital infection which may result in mental retardation and blindness in the infant . The present study aimed to evaluate the seroprevalence of Toxoplasma gondii and it i s associated risk facto rs among the women with history of spontaneous abortion . MATERIALS & METHODS: A total of 60 women with past or present history of spontaneous abortion and another 60 pregnant women without any bad obstetric history as control attending our hospital were in cluded in the study . All the serum samples were tested for the presence of specific Toxoplasma IgM and IgG antibodies using the On Site Toxo IgG/IgM Rapid Test strip , a lateral flow chromatographic immunoassay . RESULTS: Total seroprevalence of Toxoplasma gondii in the study was 12 . 5% . Total seropositivity in women with history of spontaneous abortion was 12 ( 20% and 3 ( 5% among control group . More number of seropositivity was observed among women between 26 to 30 years ( 60% . Risk factor of having cat a s pet animal had greater association of getting toxoplasmosis . CONCLUSION: This study revealed that the seroprevalence of toxoplasmosis was significantly high in the study population than in control group . There should be routine screening for antenatal wo men with bad obstetric history .

  6. Anticardiolipin antibody in recurrent spontaneous aborting and fertile women

    Egle Couto

    Full Text Available OBJECTIVE: To determine the association between the presence of anticardiolipin antibody and a history of recurrent spontaneous abortion. STUDY DESIGN: clinical controlled study LOCATION: Department of Gynecology and Obstetrics - University of Campinas (UNICAMP SUBJECTS: 52 individuals with recurrent spontaneous abortion were included in Group 1 and 104 individuals with at least one live born child in Group 2. Elapsed time from last delivery to blood sampling varied from six months to two years. METHOD: Between November 1993 and November 1994, patients' blood samples were screened for anticardiolipin antibody by ELISA, as described by Triplett, Barna and Unger (1993. ANALYSIS: Chi-square and Fisher's Exact tests were used for statistical analysis. Student's "t" test was used to compare the means. RESULTS: There was no statistical difference in the presence of the anticardiolipin antibody between Group I (zero and 2.9% and Group 2 (7.7 and 5.8%. CONCLUSION: There was no association between the presence of anticardiolipin antibody and recurrent spontaneous abortion.

  7. Factors Analysis of Spontaneous Abortion after Thawed-vitrified Blastocysts Transfer

    Dong YANG; Zheng-yi SUN; Cheng-yan DENG; Qi YU; Fang-fang HE

    2008-01-01

    Objective To investigate the factors resulting in spontaneous abortion after transferring frozen-thawing blastocysts. Methods A total of 108 cases transferring vitrified blastocysts were divided into two groups: abortion group (n =20) and ongoing group (n=88). Cytogenetic analysis of apoblemas was performed in 12 cases of the abortion.Results The overall spontaneous abortion rate was 18.50%(20/108) and the early spontaneous rate was 16.67%(18/108). ,4 significant difference in maternal age was observed (abortion group: 33.3±4.0 years, ongoing group: 31.0±3.6 years, P=0.02). No difference in other parameters was found. Cytogenetic analysis of apoblemas was obtained for 12 cases, and 2 specimens were contaminated. Seven of ten patients had abnormal karyotypes. Conclusion The underlying cause of spontaneous abortion after transferring frozen thawing blastocysts appears to be abnormal karyotypes.Advancing maternal age seems to increase the risk of spontaneous abortion.

  8. Hypovolemic shock following induced abortion and spontaneous heterotopic pregnancy.

    Pakniyat, Abdolghader; Yazdanbakhsh, Arash; Moshar-Mowahed, Ghasem; Talebi, Fatimah

    2015-12-01

    Spontaneous heterotopic pregnancy is a rare clinical condition in which intrauterine and extrauterine pregnancies occur at the same time. It is rare, estimated to occur in 1 in 30,000 pregnancies. The case was a 38-year-old woman with spontaneously conceived heterotopic pregnancy. She was admitted to our center with hypovolemic shock. Focused assessment sonography for trauma examination in emergency department showed large amount of free fluid in peritoneal cavity. She was managed surgical laparotomy. Considering spontaneous pregnancies, physician should be aware of the possibility of heterotopic pregnancy in all reproductive age women, especially those with history of recent abortion. It can occur without any predisposing risk factors. Patients should be informed about possible side effects of nonprescription medicines, and also the health care centers must be safe peaceful environment for them without severe legal consequences.

  9. Hypovolemic shock following induced abortion and spontaneous heterotopic pregnancy

    Abdolghader Pakniyat

    2015-01-01

    Full Text Available Spontaneous heterotopic pregnancy is a rare clinical condition in which intrauterine and extrauterine pregnancies occur at the same time. It is rare, estimated to occur in 1 in 30,000 pregnancies. The case was a 38-year-old woman with spontaneously conceived heterotopic pregnancy. She was admitted to our center with hypovolemic shock. Focused assessment sonography for trauma examination in emergency department showed large amount of free fluid in peritoneal cavity. She was managed surgical laparotomy. Considering spontaneous pregnancies, physician should be aware of the possibility of heterotopic pregnancy in all reproductive age women, especially those with history of recent abortion. It can occur without any predisposing risk factors. Patients should be informed about possible side effects of nonprescription medicines, and also the health care centers must be safe peaceful environment for them without severe legal consequences.

  10. Male Factors and socioeconomic indicators correlate with the risk of spontaneous abortion

    Olsen, Jørn; Basso, Olga; Christensen, Kaare

    1999-01-01

    the personal identification numbers and information stored in several population registers. Change of partner reduced the recurrence risk of spontaneous abortion substantially (OR = 0.59; 95 CI 0.52-0.67), but also changes in social status or job reduced the recurrence risk significantly. Changing...... the municipality of residence to a low risk area (based upon the geographical distribution of spontaneous abortions) reduced the risk of spontaneous abortion in both cohorts. A paternal effect on the recurrence risk of spontaneous abortion cannot be ruled out but environmental factors also play a role....

  11. Anti-Thyroid Peroxidase and Risk of Recurrent Spontaneous Abortion

    Tahereh Madani

    2007-01-01

    Full Text Available Background: Approximately 2-4% of all women have recurrent spontaneous abortion (RSA; however, the cause is determined in only 50% of cases. Recent studies have shown an association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion. The aim of the present study was to determine whether circulating anti-thyroid peroxidase (anti-TPO was associated with RSA.Materials and Methods: In this observational analytic study, Sera from 58 non-pregnant women with a history of RSA and also 58 healthy, fertile subjects with at least one live birth as control (Aging from 18 to 45 years were tested for thyroid peroxidase antibodies by means of a standard Anti-TPO ELISA kit. We used data collection forms and SPSS software for data analysis.Results: Of 116 women, 8 (13.8% of the control subjects and 12 (20.7% of the women with a history of RSA had positive results for anti-TPO. There was not any significant association between presence of anti-TPO and RSA.Conclusions: We did not find any correlation between the presence of TPO antibodies and abortion in women with a history of RSA. On the basis of this study, testing for anti-TPO doesn’t seem to be useful in the evaluation of patients with a history of RSA.

  12. Relation between some environmental pollutants and recurrent spontaneous abortion

    Aziza A. Saad

    2016-09-01

    Full Text Available Reproductive health is exquisitely sensitive to characteristics of an individual’s environment including physical, biological, behavioral, cultural and socioeconomic factors. This study was launched to elucidate the effect of the exposure to chemical pollutants as aromatic amines viz. (benzidine, mono-acetyl benzidine, diacetyl benzidine, α,β-naphthylamine as well as the biological pollutants e.g., human cytomegalovirus (HCMV as risk factors for recurrent spontaneous abortion (RSA through determination of MDA as a marker of oxidative stress and determination of some antioxidant markers. The results of the current study revealed that the aborter mothers were being exposed to environmental pollutants as aromatic amines which were manifested by the presence of benzidine, mono-acetyl-benzidine, di-acetyl-benzidine, α,β-naphthylamine in most of their urine samples, where the level of aromatic amines were more 13.6, 10, 15, and 4-folds than the control group, respectively. Also, the data suggest that in early pregnancy failure there is an increase in markers of oxidative stress and a probable decrease in maternal antioxidant defenses (22 nmol/ml and 17 mg/l, 550 U/l, respectively. Generation of ROS in large quantities, in the first trimester placenta which has limited antioxidant defenses may cause DNA damage, oxidation of protein and lipid resulting in extensive cell death. Also, it was demonstrated that high elevation of HCMV inhibits cytotrophoblasts proliferation, migration invasion and matrix metalloproteins (MMP expression. Obviously, placental toxicological responses are partly due to pharmaco/toxico dynamic responses to the chemicals. Conclusively, the aforementioned findings emphasis that, the exposures to environmental chemical and/or biological risk factors are implicated in the pathogenesis of recurrent spontaneous abortion.

  13. Spontaneous abortion: a prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants

    Buss, L; Tolstrup, J; Munk, C;

    2006-01-01

    abortions identified from both sources were recorded in the same year. During follow-up a total of 20.9% of pregnancies intended to be carried to term ended as a spontaneous abortion. In the risk factor analysis, we found that previous spontaneous abortion, being single, never having used oral...... contraceptives, and use of intrauterine device were associated with increased risk of subsequent spontaneous abortion. In addition, it was indicated that a short interpregnancy interval following a spontaneous abortion may confer an increased risk of abortion in the subsequent pregnancy. CONCLUSION: We found......OBJECTIVE: To assess the occurrence of spontaneous abortion, comparing two different data sources. To estimate the rate of spontaneous abortion over a 2-year period, and examine potential predictors of the risk for incident spontaneous abortion. METHODS: We used interview data from a population...

  14. Male-mediated spontaneous abortion among spouses of stainless steel welders

    Hjollund, N H; Bonde, Jens Peter; Jensen, Tina Kold

    2000-01-01

    Male-mediated spontaneous abortion has never been documented for humans. The welding of stainless steel is associated with the pulmonary absorption of hexavalent chromium, which has genotoxic effects on germ cells in rodents. Clinical and early subclinical spontaneous abortions were examined among...... spouses of stainless-steel welders....

  15. Validation of spontaneous abortion diagnoses in the Danish National Registry of Patients

    Lohse, Sarah Rytter; Farkas, Dóra Körmendiné; Lohse, Nicolai;

    2010-01-01

    The purpose of this study is to validate the diagnosis of spontaneous abortion (SA) recorded in the Danish National Registry of Patients (DNRP).......The purpose of this study is to validate the diagnosis of spontaneous abortion (SA) recorded in the Danish National Registry of Patients (DNRP)....

  16. Male-mediated spontaneous abortion among spouses of stainless steel welders

    Hjollund, N H; Bonde, J P; Jensen, T K

    2000-01-01

    Male-mediated spontaneous abortion has never been documented for humans. The welding of stainless steel is associated with the pulmonary absorption of hexavalent chromium, which has genotoxic effects on germ cells in rodents. Clinical and early subclinical spontaneous abortions were examined among...

  17. Genetic Screening of Couples with Recurrent Spontaneous Abortion

    M. Nail Alp

    2006-01-01

    Full Text Available The aim of this study was to determine the chromosomal abberations and their incidence in non-consanguineous couples with a history of two or more than two spontaneous abortion. In the study, we carried out cytogenetic analysis on 434 couples. Patients detected with chromosome abnormality were evaluated according to their pedigree analysis, and also patients’ relatives were screened for the same abnormality. Peripheral blood were taken from patients, then performed with lymphocyte culture and stained by binded using Giemsa-banding method. For each individual, 20-30-cells chromosomes were counted and around 5-10 well-binded metaphase chromosomes were karyotyped for numerical and structural chromosomal aberrations. Of 434 couples investigated, 30 (6.91% were found to have chromosomal abnormality, in one of couples partners. In 13 of couples (2.99%, one of partners was found to be balanced translocation carrier. Of these, 7 (1.61%were found to be reciprocal carrier, while 6 (1.38% Robertsonian-type balanced translocation carrier. Gonadal mosaicism was found in 3 couples (0.69%, pericentric 9 inversion in 8 couples (1.85 %, while 6 couples showed different chromosomal structure from each other. These chromosomal aberrations may cause of abortion due to high incidence in general population.

  18. Increase of tumor necrosis factor receptor 1 expression in women with unexplained early spontaneous abortion

    YAN Chun-fang; YU Xue-wen; JIN Hui; LI Xu

    2004-01-01

    To investigate membrane tumor necrosis factor receptor 1 protein expression level in decidua andconcentration of soluble tumor necrosis factor receptor 1 in serum in women with unexplained early spontaneous abortion,threatened abortion, and compare the levels with healthy pregnant women. Methods: Thirty-seven women with unexplainedearly spontaneous abortion, 27 women with threatened abortion, and 34 healthy pregnant women undergoing artificial abortionof pregnancy at 6 - 10 weeks of gestation were selected. Decidual samples were collected when women were undergoing arti-ficial abortion, and blood samples were collected at the same time. The level of membrane tumor necrosis factor receptor 1 indecidua was detected by flow cytometer, and the concentration of soluble tumor necrosis factor receptor 1 in sera was mea-sured with an enzyme-linked immunosorbent assay. Results: The ercentages of membrane tumor necrosis factor receptor 1positive decidual cells were 16.42 ± 7.10 Mean ± SD for women with unexplained early spontaneous abortion and 13.14 ±6.30 for healthy pregnant women ( P < 0.05). Serum oncentration of soluble tumor necrosis factor receptor 1 was signifi-cantly higher in women with unexplained early spontaneous abortion than in healthy pregnant women and in women withthreatened abortion, and no difference was found between healthy pregnant women and women with threatened abortion.Conclusion: Women with unexplained early spontaneous abortion present significantly higher expression of tumor necrosisfactor receptor 1 than healthy pregnant women, suggesting that over-expression of tumor necrosis factor receptor 1 may cont-ribute to the development of early spontaneous abortion.

  19. Use of antiepileptic drugs during pregnancy and risk of spontaneous abortion and stillbirth

    Bech, Bodil Hammer; Kjaersgaard, Maiken Ina Siegismund; Pedersen, Henrik Søndergaard;

    2014-01-01

    Dette studie undersøger, om brugen af antiepileptika under graviditeten kan øge risikoen for spontan abort eller dødfødsel. Resultaterne viser, at 16 ud af 100 gravide kvinder, som brugte antiepileptika, mistede fostret ved en spontan abort, mens det kun var 13 ud af 100 gravide kvinder, som ikke...... brugte antileptika. Der var dog forskel på, om de kvinder, der valgte at bruge antiepileptika under graviditeten, var diagnosticeret med epilepsi eller ej. I analyser alene af kvinder med epilepsi var der ingen forskel i risikoen for spontan abort, når kvinder, der indtog medicin i graviditeten, blev...... sammenlignet med kvinder, der ikke indtog medicin. Hos kvinder uden epilepsi havde de, der indtog medicin, en 30 % øget risiko for spontan abort sammenlignet med dem, der ikke indtog medicin. Forskellen kan måske forklares ved manglende kontrol for andre risikofaktorer (confounding). Analyserne tager højde...

  20. Effects of sera taken from women with recurrent spontaneous abortion on sperm motility and apoptosis

    2011-01-01

    Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. Objective: The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility. Materials and Methods: Sera of 20 women with URSA history...

  1. Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions

    M Trovato

    2009-06-01

    Full Text Available In the present study, using immunohistochemistry, we studied the expression of CD30 and CD30-L in 35 deciduas obtained from women following elective abortion during normal physiological gestation and in 60 deciduas obtained from women after spontaneous abortion with or without signs of inflammation. The main difference was noticed in the first trimester of gestation in which was found a decrease in CD30/CD30-L-positive decidual glandular and stromal cells in a greater number of cases of spontaneous abortions with respect to cases of physiological pregnancies (70% vs 50%, p<0.05. In addition, deciduas from spontaneous abortions with inflammation and without inflammation reacted similarly. The reduced expression of CD30 and CD30-L and their cellular pattern detected in the deciduas from spontaneous abortions suggest that the CD30/CD30-L system is crucial for preventing abortions in the first trimester. And furthermore, the distinctive expression of CD30/CD30- L in deciduas from physiological pregnancies may indicate that the CD30/CD30-L system exerts its main role in the first trimester.

  2. Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment

    Kim You

    2010-11-01

    Full Text Available Abstract Background We evaluated cytogenetic results occurring with first trimester pregnancy loss, and assessed the type and frequency of chromosomal abnormalities after assisted reproductive treatment (ART and compared them with a control group. We also compared the rate of chromosomal abnormalities according to infertility causes in ICSI group. Methods A retrospective cohort analysis was made of all patients who were referred to the Genetics Laboratory of Fertility Center of CHA Gangnam Medical Center from 2005 to 2009 because of clinical abortion with a subsequent dilation and evacuation (D&E performed, and patients were grouped by type of conception as follows: conventional IVF (in vitro fertilization (n = 114, ICSI (intracytoplasmic sperm injection (n = 140, and control (natural conception or intrauterine insemination [IUI] (n = 128. Statistical analysis was performed using SPSS software. Results A total 406 specimens were referred to laboratory, ten abortuses were excluded, and in 14 cases, we did not get any spontaneous metaphase, chromosomal constitutions of 382 specimens were successfully obtained with conventional cytogenetic methods. Overall, 52.62% of the miscarriages were found to be cytogenetically abnormal among all patients, the frequency was 48.4% in the control group, 54.3% of miscarriages after ICSI and 55.3% after conventional IVF (p = 0.503. The most prevalent abnormalities were autosomal trisomy, however, nine (11.69% sex chromosome aneuploidy were noted in the ICSI group vs. four (6.45% and two (3.23% cases in the conventional IVF group and control group. We compared chromosomal abnormalities of miscarriages after ICSI according to infertility factor. 55.71% underwent ICSI due to male factors, 44.29% due to non-male factors. ICSI group having male factors showed significantly higher risk of chromosomal abnormalities than ICSI group having non-male factors (65.8% vs. 34.2%, p = 0.009, odds ratio = 1.529, 95% CI = 1

  3. Sexual history and contraception among women with induced and spontaneous abortion in Dar es Salaam

    Rasch, V; Mary, V; Urassa, E;

    2007-01-01

    The objective of this study was to create sexual history profiles of women with illegally induced abortion (IA) and women with spontaneous abortion (SA) and describe the women's knowledge of, attitude to, and practice of contraception. The study was carried out in two settings, Temeke District...... the rate of ever users of contraception was low in both groups, although significantly lower among IA women than among SA women. Outcome of first pregnancy had been an induced abortion in significantly higher proportion of IA than of SA women. In conclusion, sexual intercourse before marriage is common...

  4. Validation of spontaneous abortion diagnoses in the Danish National Registry of Patients

    Lohse, Sarah Rytter; Farkas, Dóra Körmendiné; Lohse, Nicolai;

    2010-01-01

    PURPOSE: The purpose of this study is to validate the diagnosis of spontaneous abortion (SA) recorded in the Danish National Registry of Patients (DNRP). METHODS: We randomly selected patients registered in the DNRP with a diagnosis of SA between 1980 and 2008 from hospitals in the county of North...... the three patients with available data who did not fulfill the criteria for SA, one had an induced abortion and two had threatened abortion but did not miscarry. CONCLUSION: Registration of SA in the DNRP accurately reflects the diagnoses recorded in medical charts. The DNRP is a suitable source of data...

  5. Assessment of Relationship between Spontaneous Abortion and Occupational Exposure to Organic Solvents

    S Mohammadi

    2011-04-01

    Full Text Available Introduction & Objective: Nowadays, some studies indicate the adverse effects of exposure to chemicals, especially organic solvents on the reproductive system of females. This study aimed to assess the relationship between spontaneous abortion with occupational exposure to organic solvents in pharmaceutical industry. Materials & Methods: This is a cross-sectional and descriptive-analytical study which was carried out in 2010 in one of the pharmaceutical factories located in the suburbs of Tehran. During the study, married women who were working in the factory laboratory units and were exposed to mixed organic solvents were compared with married women who were working in the packing units of the factory without occupational exposure to organic solvents. Frequency of spontaneous abortion and duration of pregnancy were assessed in both two groups. Collected data were analyzed with the SPSS software using t-test, logistic regression, and chi-square test. Results: In the present study, the frequency of spontaneous abortion in employees with exposure to organic solvents mixture was 10.7%. This study showed that even after adjustment for confounding factors, there was a significant correlation between spontaneous abortion and occupational exposure to organic solvents mixture and this correlation increased with increasing levels of exposure to organic solvents. Moreover, a significant correlation was observed between occupational exposure to mixed organic solvents and waiting time to become pregnant (TTP. Furthermore, this study showed that even after adjustment for confounding variables, shift workers were significantly more affected by spontaneous abortion compared to daytime workers (P < 0.001. Conclusion: According to the results of this study, since there is probability of spontaneous abortion resulting from occupational exposure to various chemicals including organic solvents, review of the status of occupational exposure of workers can be helpful

  6. [Current role of progesterone therapy in the prevention of spontaneous abortion and in the treatment of threatened abortion].

    Marzetti, L; Boni, T; Fazzio, M; Giobbe, M

    2000-12-01

    Progesterone therapy is often used to prevent spontaneous abortion. In this paper the most significant studies on the benefits and risks of this treatment over the last 30 years are analyzed. None of these studies about the effects of progesterone as non-specific therapy in abortion risk and recurrent miscarriage, proved a reduced pregnancy wastage in treated patients compared with patients who received no treatment. The results concerning the use of progesterone in recurrent miscarriage for luteal phase inadequacy are more controversial, but they are still inadequate to encourage progesterone supplementation. To obtain a definitive conclusion about progesterone therapy real effectiveness, it is necessary to carry out randomized double-blind prospected trials. As regards the risks of using progesterone therapy during pregnancy, even if a possible teratologic role has certainly been reduced, it cannot be excluded completely yet. Moreover a high incidence of respiratory problems has been noticed in newborns from patients treated with progesterone, compared with control groups.

  7. Bacterial vaginosis in association with spontaneous abortion and recurrent pregnancy losses

    Gözde Isik

    2016-01-01

    Full Text Available Context: Bacterial vaginosis (BV is related to the increased risk of miscarriage, preterm labor, and postpartum endometritis. Aims: The aim of this study was to evaluate the association between BV and the history of spontaneous abortion and recurrent pregnancy losses. We also examined periods of gestation, including the first and second trimester miscarriages. Materials and Methods: The study population consisted of 200 fertile women. Sixty one (30.5% of 200 women had the history of a spontaneous abortion in the last six months (N = 30 and at least three recurrent pregnancy losses (N = 31. BV was diagnosed either by using Papanicolaou staining, Gram staining, or by culturing with BV-associated bacteria, Gardnerella vaginalis. Results: The presence of BV was statistically associated with the history of a spontaneous abortion in the last 6 months (P 0.05. These women were also evaluated in view of periods of gestation. Forty-seven (77% of 61 women had first trimester miscarriage (≤12 weeks and 14 (23% of 61 women had second trimester miscarriage (>12 weeks. There was a statistically significant relationship between BV and second trimester miscarriage (P 0.05. Conclusion: BV may contribute to spontaneous abortion and second trimester miscarriage.

  8. Metformin exposure in early pregnancy and spontaneous abortions in women with polycystic ovary syndrome

    Lauszus, Finn; Viftrup-Lund, Mette; Gade, Melina

    2014-01-01

    Objective: We sought to determine whether metformin affects the rate of first trimester spontaneous abortions and congenital malformations in women with PCOS. Design. Consecutive series of metformin treated women with a questionnaire followup. Setting. Department of Gynecology and Obstetrics at H...

  9. Hypovolemic shock following induced abortion and spontaneous heterotopic pregnancy

    Abdolghader Pakniyat; Arash Yazdanbakhsh; Ghasem Moshar-mowahed; Fatimah Talebi

    2015-01-01

    Spontaneous heterotopic pregnancy is a rare clinical condition in which intrauterine and extrauterine pregnancies occur at the same time. It is rare, estimated to occur in 1 in 30,000 pregnancies. The case was a 38-year-old woman with spontaneously conceived heterotopic pregnancy. She was admitted to our center with hypovolemic shock. Focused assessment sonography for trauma examination in emergency department showed large amount of free fluid in peritoneal cavity. She was managed surgical la...

  10. Correlation of enhanced oxidative stress with altered thyroid profile: Probable role in spontaneous abortion

    Ramandeep, Kaur; Kapil, Gupta; Harkiran, Kaur

    2017-01-01

    Background: Spontaneous abortion or miscarriage is defined as the loss of a clinically recognized pregnancy that occurs before 20 weeks of gestational age. Changes in thyroid function can impact greatly on reproductive function before, during, and after conception. Oxidative stress affects both implantation and early embryo development by modifying the key of transcription. Malondialdehyde (MDA) is a major breakdown product of split off from lipid peroxidation. Superoxide dismutase (SOD) is responsible for detoxification of superoxide anion and required for normal health and reproduction. Aim: The aim of this study was to define the involvement of thyroid hormones, MDA and SOD levels and to establish MDA levels as an index of lipid peroxidation in women with spontaneous abortion by comparing the results with healthy pregnant females as controls. Materials and Methods: A cross-sectional case-control study was designed with two groups of women with 30 each in healthy pregnancy and with spontaneous abortion. Results: Demographic characteristics such as maternal age, paternal age, gestational age, body mass index, waist-hip ratio as well as biochemical parameters such as blood pressure, hemoglobin (Hb), sugar levels were found to be similar in both the participating groups. Characteristics like gravida and parity were found to be higher in the study group and differ significantly from control group. Spontaneous abortion before 24 weeks of gestational age was found to be associated with significant increase in mean serum thyroid stimulating hormone (TSH) (P = 0.0115) and MDA (P = 0.0001) levels and a significant decrease in mean serum T3 (P = 0.0003) and SOD (P = 0.0005) levels. The linear (Pearson) correlation analysis demonstrated a significant positive correlation of TSH with MDA and negative correlation with SOD in women with spontaneous abortion. Conclusion: The study demonstrates that altered thyroid profile, increased lipid peroxidation in terms of increased MDA

  11. Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice.

    Wang, Xiaoli; Chen, Xiaojiao; Feng, Xuejiao; Chang, Fei; Chen, Minjian; Xia, Yankai; Chen, Ling

    2015-12-15

    Triclosan (TCS), an antibacterial agent, is identified in serum and urine of humans. Here, we show that the level of urinary TCS in 28.3% patients who had spontaneous abortion in mid-gestation were increased by 11.3-fold (high-TCS) compared with normal pregnancies. Oral administration of TCS (10 mg/kg/day) in mice (TCS mice) caused an equivalent urinary TCS level as those in the high-TCS abortion patients. The TCS-exposure from gestation day (GD) 5.5 caused dose-dependently fetal death during GD12.5-16.5 with decline of live fetal weight. GD15.5 TCS mice appeared placental thrombus and tissue necrosis with enhancement of platelet aggregation. The levels of placenta and plasma estrogen sulfotransferase (EST) mRNA and protein in TCS mice or high-TCS abortion patients were not altered, but their EST activities were significantly reduced compared to controls. Although the levels of serum estrogen (E2) in TCS mice and high-TCS abortion patients had no difference from controls, their ratio of sulfo-conjugated E2 and unconjugated E2 was reduced. The estrogen receptor antagonist ICI-182,780 prevented the enhanced platelet aggregation and placental thrombosis and attenuated the fetal death in TCS mice. The findings indicate that TCS-exposure might cause spontaneous abortion probably through inhibition of EST activity to produce placental thrombosis.

  12. Measurement of total risk of spontaneous abortion: the virtue of conditional risk estimation

    Modvig, J; Schmidt, L; Damsgaard, M T

    1990-01-01

    abortion risk include biochemical assays as well as life table technique, although the latter appears in two different forms. The consequences of using either of these are discussed. It is concluded that no study design so far is appropriate for measuring the total risk of spontaneous abortion from early...... conception to the end of the 27th week. It is proposed that pregnancy may be considered to consist of two or three specific periods and that different study designs should concentrate on measuring the conditional risk within each period. A careful estimate using this principle leads to an estimate of total...

  13. Abortion

    2005-01-01

    Abortion is not only a sin; it is also a crime as Canon Law describes it. The paper deals with the issue of abortion from the Canon Law's perspective. Not every sin of abortion is at the same time a crime in the legal sense. The paper discusses what the circumstances are to turn the sin of abortion into the crime of abortion. The censure of excommunication is imposed on the individuals who are guilty of the crime of abortion. If there is no crime, there is no excommunication which is attached...

  14. Abortion

    An abortion is a procedure to end a pregnancy. It uses medicine or surgery to remove the embryo or ... personal. If you are thinking of having an abortion, most healthcare providers advise counseling.

  15. Change of T, B lymphocyte subsets and Th1/Th2 indexes of patients with recurrent spontaneous abortion

    Shi-Hua Zhou

    2016-01-01

    Objective:To analyze and investigate the change state of T, B lymphocyte subsets and Th1/Th2 indexes of patients with recurrent spontaneous abortion. Methods: A total of 92 patients with recurrent spontaneous abortion in our hospital from June 2013 to July 2015 were selected as the observation group and 92 women with health delivery history at the same time were selected as the control group,then the peripheral blood T, B lymphocyte subsets and Th1/Th2 indexes of two groups were detected and compared and the peripheral blood T, B lymphocyte subsets and Th1/Th2 indexes of patients with different gestational age at abortion and abortion times were compared too. Results:The peripheral blood T, B lymphocyte subsets and Th1/Th2 indexes of observation group and control group all had obvious differences,and those blood indexes levels' differences of patients with different gestational age at abortion and abortion times were obvious too, all P<0.05 and the differences were significant. Conclusions: The T, B lymphocyte subsets and Th1/Th2 indexes of patients with recurrent spontaneous abortion show abnormal state and the differences of detection results of patients with different gestational age at abortion and abortion times are relatively obvious,so those indexes should be monitored and improved intentinonally.

  16. Isolation and Characterization of a Black-Pigmented Corynebacterium sp. from a Woman with Spontaneous Abortion

    Shukla, Sanjay K.; Vevea, Dirk N.; Daniel N Frank; Pace, Norman R.; Reed, Kurt D.

    2001-01-01

    An unusual black-pigmented coryneform bacterium was isolated from the urogenital tract of a woman who experienced a spontaneous abortion during month 6 of pregnancy. Biochemical and chemotaxonomic analyses demonstrated that the unknown bacterium belonged to the genus Corynebacterium. Phylogenetic analysis based on 16S rRNA sequences (GenBank accession no. AF220220) revealed that the organism was a member of a distinct subline which includes uncultured Corynebacterium MTcory 1P (GenBank access...

  17. Presence of antibodies against Coxiella burnetii and risk of spontaneous abortion

    Nielsen, Stine Yde; Hjøllund, Niels Henrik; Andersen, Anne-Marie Nybo;

    2012-01-01

    Q fever is a bacterial zoonosis caused by infection with Coxiella burnetii. It is well established that Q fever causes fetal loss in small ruminants. The suspicion has been raised that pregnant women may also experience adverse pregnancy outcome when the infection is acquired or reactivated durin...... pregnancy. The purpose of this study was to assess the potential association between serologic markers of infection with C. burnetii and spontaneous abortion....

  18. Complications and the effect of varicocelectomy on semen analysis, fertility, early ejaculation and spontaneous abortion

    Shamsa Ali

    2010-01-01

    Full Text Available Varicocele is still an enigma. Its effects on semen analysis, fertility and, more re-cently, early ejaculation and spontaneous abortion in spouses are not yet fully understood. In this retrospective study, we evaluated these four parameters (semen analysis, fertility, early ejacu-lation and spontaneous abortion among spouses in relation to varicocele and varicocelectomy during a 13-year period. A total of 1,711 patients with varicocele underwent varicocelectomy by high inguinal method (251 cases, subinguinal method (1,375 cases, scrotal method (34 cases, and subinguinal method with local anesthesia (38 cases. Our complication rate was acceptable. Sperm count, motility and morphology increased three months post operation in 55, 51, and 46%, respectively (P value 0.000, 0.000, and 0.015, respectively. Paternity was 56% after one year of post varicocelectomy follow-up. Only 7 out of 82 azoospermic men had sperm in their semen after varicocelectomy and only one of them with mild spermatogenic hypoplasia became a father. The spontaneous abortion rate in the spouses of respondents was 59%. Early ejaculation improved in 75% of the respondents. In conclusion, varicocelectomy does not improve sperm parameters in all men, but it improves pregnancy rate, early ejaculation, and scrotal pain.

  19. Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?

    Tolstrup, J S; Kjær, S. K.; Munk, C

    2003-01-01

    BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case-control study using prospective data from a population......-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol...... at enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre-pregnancy intake of caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1...

  20. Expression of the Inducible Nitric Oxide Synthase Isoform in Chorionic Villi in the Early Spontaneous Abortion

    2000-01-01

    To investigate the relationship between inducible nitric oxide synthase (iNOS) and the early spontaneous abortion. , in situ hybridization and immunohistochemistry were used to detect the expression of iNOS in trophoblasts in the early pregnancy with and without spontaneous abortion (group Ⅰ and group Ⅱ ). By light microscopy and computer color magic image analysis system (CMIAS), light density (D) and the positive cell number per statistic square (N/S) in situ hybridization were used to analyze the positive cell index, while total positive cells (N) and the positive unit (Pu) were used in immunohistochemistry. By in situ hybridization, D and N/S in trophoblasts were 0. 35±0. 028, 0. 07±0. 011 respectively in group Ⅰ and 0. 18±0. 016,0. 015±0. 003 in group Ⅱ . In terms of immunohistochemical staining, N and Pu were 0. 058±±0. 007, 11. 94±2. 01 in group Ⅰ and 0. 013±0. 009, 1. 08±0. 35 in group Ⅱ in trophoblasts. Significant differences existed between two groups. It is concluded that the higher nitric oxide produced by the higher expression of iNOS in trophoblasts might play an important role in the early spontaneous abortion.

  1. Individualized Hormone Adjustment in the Treatment of Recurrent Spontaneous Abortions.

    Shang, Wei; Wang, Aiming; Lv, Libo; Zhang, Lei; Shu, Mingming; Zhao, Yong; Hui, Shang

    2015-07-01

    Our goal was to develop a safe, efficient, and practical clinical plan for successful pregnancies for patients with recurrent spontaneous miscarriages by adjustment of their hormone levels after ovulation. We treated 61 patients with recurrent miscarriages and 110 patients with two miscarriages. All patients had miscarriages before or during the 12th week of pregnancy, and unsuccessfully underwent progesterone therapy. We measured their hormone levels and administered appropriate doses of estrogen, progesterone, and luteinizing hormones to attain normal levels (respectively, 150 pg/ml, 16 ng/ml, and 6 mIU/ml). The hormone doses were reduced upon detection of fetal heart beating, and the treatment continued until the 12th week of pregnancy. The patients were followed up by phone after the child birth. In patients with recurrent miscarriages, these were prevented in 57/61 (93.44 %). In patients with two miscarriages, successful pregnancies were in 106/110 (96.4 %) patients. The vast majority of patients in both groups gave birth to healthy babies. There was only one case per each group of induced labor due to trisomy 21 (patient with a history of recurrent miscarriages) or trisomy 17 (patient with two previous miscarriages). Individualized adjustment of hormone levels after ovulation prevents miscarriages and improves the pregnancy success rates.

  2. Concomitant infection of Neospora caninum and Bovine Herpesvirus type 5 in spontaneous bovine abortions

    Maia S. Marin

    2013-11-01

    Full Text Available Bovine Herpesvirus type 5 (BoHV-5 has not been conclusively demonstrated to cause bovine abortion. Brain lesions produced by Neospora caninum and Bovine Herpesvirus type 1 (BoHV-1 exhibit common features. Therefore, careful microscopic evaluation and additional diagnostic procedures are required to achieve an accurate final etiological diagnosis. The aim of the present work was to investigate the occurrence of infections due to BoHV-1, BoHV-5 and N. caninum in 68 cases of spontaneous bovine abortions which showed microscopic lesions in the fetal central nervous system. This study allowed the identification of 4 (5.9% fetuses with dual infection by BoHV-5 and N. caninum and 33 (48.5% cases in which N. caninum was the sole pathogen identified. All cases were negative to BoHV-1. The results of this study provide evidence that dual infection by BoHV-5 and N. caninum occur during pregnancy in cattle; however, the role of BoHV-5 as a primary cause of bovine abortion needs further research. Molecular diagnosis of BoHV-5 and N. caninum confirmed the importance of applying complementary assays to improve the sensitivity of diagnosing bovine abortion.

  3. Expression and activity of matrix metalloproteinases in the uterus of bitches after spontaneous and induced abortion.

    Kanca, H; Walter, I; Miller, I; Schäfer-Somi, S; Izgur, H; Aslan, S

    2011-04-01

    Aim of this study was to determine the intrauterine activity of matrix metalloproteinases (MMP)-2 and -9 after cessation of the local effect of progesterone. For this purpose, pregnancy was terminated in 10 bitches at mid-gestation with the progesterone receptor antagonist aglepristone (10 mg/kg body weight, sc, Alizine®; Virbac, France) at two subsequent days (group IRA = induced resorption/abortion). The IRA group was divided into two subgroups (Group I, n = 5, days 25-35 of pregnancy; group II, n = 5, days 36-45). Five further bitches were introduced with beginning abortion (group SRA = spontaneous resorption/abortion). Seven healthy bitches between day 25 and 45 of gestation served as controls. After ovariohysterectomy at the end of abortion and between days 25 and 45 of gestation, respectively, the distribution and activity of collagenases were investigated by immunohistochemistry and gelatin zymography. At placental sites, MMP-2 activity in the endometrium was significantly lower in IRA groups than in the SRA group (33.7 ± 11.8% and 39.3 ± 5.4% vs 52.2 ± 10.2%, p control group (control: 21.4 ± 6.3%; p controls: 13.1 ± 2.5%; p control group in comparison to SRA and IRA groups (11.8 ± 3.2%; p control group. It is concluded that the blockade of the biological progesterone effect was associated with an increase in activity of both collagenases.

  4. Validation of spontaneous abortion diagnoses in the Danish National Registry of Patients

    Sarah Rytter Lohse

    2010-10-01

    Full Text Available Sarah Rytter Lohse1, Dóra Körmendiné Farkas1, Nicolai Lohse1, Sven Olaf Skouby2, Finn Erland Nielsen3, Timothy L Lash1, Vera Ehrenstein11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark; 2Department of Obstetrics and Gynecology, 3Department of Cardiology, Herlev University Hospital, Herlev, DenmarkPurpose: The purpose of this study is to validate the diagnosis of spontaneous abortion (SA recorded in the Danish National Registry of Patients (DNRP.Methods: We randomly selected patients registered in the DNRP with a diagnosis of SA between 1980 and 2008 from hospitals in the county of North Jutland and searched for their discharge records in hospital files. We estimated positive predictive value (PPV of the DNRP diagnosis and stratified the analysis by period (1980–1994 versus 1995–2008, hospital type (regional versus local, and International Classification of Diseases revisions (ICD-8 versus ICD-10.Results: We could identify hospital files of 117/174 (67% sampled registration records. Of those, the diagnosis was confirmed in 114 patients, yielding a PPV of 97.4% (95% confidence interval = 92.7%–99.5%. The PPV did not markedly vary by period, hospital type, or ICD revision. Among the three patients with available data who did not fulfill the criteria for SA, one had an induced abortion and two had threatened abortion but did not miscarry.Conclusion: Registration of SA in the DNRP accurately reflects the diagnoses recorded in medical charts. The DNRP is a suitable source of data on SAs for epidemiologic research.Keywords: spontaneous abortion, validation, diagnosis, Danish National Registry of Patients, positive predictive value

  5. Expression of Apoptosis and Inducible Nitric Oxide Synthase in Trophoblastic Cells in Early Spontaneous Abortion

    夏革清; 孙永玉

    2001-01-01

    Objective To investigate the effect of apoptosis and inducible nitric oxide (Inos) on the early spontaneous abortion Methods TUNEL method was used to detect the apoptosis in trophoblast cells in early pregnancy with and without spontaneous abortion (the experiment group and the control group), while Inos was detected by both in situ hybridization and immunohis tochemistry. By computer color magic image analysis system (CMIAS), positive cell indexes were represented by D (density) and N/S (number/square) in both apoptosis and in situ hybridization, in immunohistochemistry were N/S and PU (positive unit).Results Positive cell indexes of apoptosis D and N/S were significntly higher in the experiment group (0. 48± 0. 004, 0. 045±0. 002) than that in the control group( 0. 35 +0. 06, 0. 031±0. 003. P<0. 001). D and N/S of inducible nitric oxide synthase in situ hybridization were 0. 33± 0. 028, 0. 074± 0. 001 respectively in the experiment group and 0. 13± 0. 015, 0. 019± 0. 004 respectively in the control group. N/S and PU were significantly higher in the experiment group( 0. 058± 0. 007, 11. 94± 2. 01)than that in the control group (0. 007± 0. 001, 1. 18± 0. 35, P<0. 01). There existed a positive correlation between Inos and apoptosis too.Conclution Apoptosis and Inos in trophoblasts might play an important role in early spontaneous abortion and there was a positive correlation between apoptosis and Inos.

  6. Study on the homocysteine metabolism of patients with unexplained repeated spontaneous abortion

    2003-01-01

    Objective:To study the metabolism abnormality of homocysteine(Hcy) in unexplained repeated spontaneous abortion(URSA).Methods:The level of Hcy in sera was measured with hyperpressure liquid chromatography(HPLC);Folic acid and vitamin B12 were detected by radioimmune assay;anticardiolipin antibody (ACA) was detected by ELISA.Results:(1)The level of serum Hcy in URSA group was significantly higher than that in control group,showing a statistical significant difference(P<0.01).The level of Hcy was correlated with ages,but not correlated with areas,numbers of miscarriage,gestation age,primary or secondary abortions.(2)The levels of folic acid and vitamin B12 in URSA group were significantly lower than those in control group.The levels of serum folic acid and vitamin B12 were not correlated with age,area,numbers of miscarriage and abortion periods.(3)ACA positive rate in URSA was significantly higher than that in control group.The level of Hcy in ACA(+) group was significantly higher than that in ACA(-) group among URSA patients.Conclusions:Hyperhomocysteinemia,low folic acid state,and ACA were all the independent risk factors for URSA.Lacking of folic acid and vitamin B12 is one of the important causes of hyperhomocysteinemia.ACA and hyperhomocysteinemia may have synergistic action in the occurrence of URSA.

  7. A case of uterine rupture in mid-trimester spontaneous abortion: a complication of gemeprost vaginal administration.

    La Torre, R; Bevilacqua, E; D'Ambrosio, V; Pasquali, G; Aliberti, C; Perrone, G; Giancotti, A

    2014-01-01

    The only prostaglandin analogue licensed in Italy for induction of labour in spontaneous and therapeutic abortion is gemeprost. The authors report a case of spontaneous uterine rupture of a scarred uterus, for previous caesarean sections, in a woman at 20 weeks of gestation with a diagnosis of spontaneous abortion. She received a pessary of gemeprost every three hours. After the fifth pessary, she complained of severe pain. At the ultrasound examination, uterine cavity appeared empty and the dead fetus was dislocated in the abdomen. Emergency laparotomy was performed and uterine tear was repaired. To induce labour for fetal demise or therapeutic abortion in second trimester in women with scarred uterus, the authors decided to lengthen the time between administrations of pessary from four to five hours depending on patient's symptoms. However the appropriate drug regimen has still to be found and more data are necessary.

  8. Toxoplasma gondii presence in women with spontaneous abortion in Yucatan, Mexico.

    Vado-Solís, Ignacio A; Suárez-Solís, Víctor; Jiménez-Delgadillo, Bertha; Zavala-Velázquez, Jorge E; Segura-Correa, José C

    2013-04-01

    The objective of this study was to estimate the seroprevalence of anti- Toxoplasma gondii antibodies and DNA of women with spontaneous abortions in 2 hospitals located in Yucatan, Mexico. Between June 2008 and May 2009, blood samples were taken from 100 women with spontaneous abortion attending the Ticul City Communitarian Hospital and the Merida Mother-Kid Hospital. The sera were tested for anti- T. gondii IgG and IgM antibodies. Blood samples (5 ml with anticlotting agent) were also used for polymerase chain reaction (PCR) assay, to detect T. gondii DNA. Forty-two of the 100 samples were negative. Of the positive samples (n = 58), 32 were positive to IgG, 2 to IgM, 5 to IgG and IgM, 6 to IgG and PCR, 1 to IgM and PCR, and 12 to IgG, IgM, and PCR. Accordingly, 55% of the women were seropositive to at least IgG, 20% to at least IgM, and 19% via PCR. Differences between hospitals were significant (P women patients at the Merida Mother-Kid Hospital, than those at the Ticul Communitarian Hospital. More studies are needed to evaluate the impact of this disease and to establish strategies to follow in order to reduce congenital toxoplasmosis in the populations at risk.

  9. A search for uniparental disomy associated with Cornelia de Lange syndrome and with spontaneous abortion

    Smith, M.J.; Upadhyaya, M.; Clarke, A. [Wales College of Medicine, Cardiff (United Kingdom)] [and others

    1994-09-01

    Uniparental disomy (UPD) is the inheritance of a pair of homologous chromosomes from one parent with no corresponding homologue from the other, in an individual with an apparently normal karyotype. Polymorphic DNA markers for the appropriate chromosome will therefore lack alleles from the non-contributing parent. There may be pathological consequences of UPD if an imprinted gene(s) resides on the affected chromosome. A number of human developmental disorders of unknown etiology, including Cornelia de Lange syndrome (CdLS) and spontaneous abortion, may be caused by imprinted genes yet to be discovered. There are a number of reports of chromosome 3q rearrangements associated with CdLS, therefore excluding whole-chromosome 3 UPD as a cause in these patients. We are also examining DNA markers for all autosomes in a series of 42 karyotypically normal spontaneous abortions and their parents. To date, no UPD has been observed for chromosomes 3, 17, 20, 21 and 22. Further work is in progress, both here and using the DNA typing facilities at Geneathon, France.

  10. [Herpetic infection of spermatozoa in failure of reproductive technologies and spontaneous abortion].

    Bocharova, E N; Bragina, E E; Gusak, Iu K; Zotov, V V; Tereshchenko, A B; Shileĭko, L V; Kurilo, L F; Klimova, R R; Kushch, A A

    2007-01-01

    Herpes simplex virus (HSV) was studied in ejaculate of 36 men whose wives had the history of spontaneous abortions, or failure of artificial insemination (AI), or extracorporeal fertilization (ECF). The control group consisted of 222 patients examined prophylactically after urogenital inflammation or for primary infertility. HSV was detected with immunofluorescence (IF) reaction with monoclonal antibodies to HSV antigens, rapid culture method (RCM) and transmission electronic microscopy. HSV antigens were detected in fraction of mobile spermatozoa in 13 (65%) of 20 samples from patients of the study group. HSV detectability in the study group was significantly higher than in the controls (p = 0.003). Intragametic capsides of HSV were detected at ultrastructural investigation in 13 of 19 (68%) ejaculate samples from patients of the study group in whom IF and/ or RCM results were positive. The study of 6 ejaculate samples of this group in which HSV was not detected by IF or RCM and 24 control samples HSV capsides were not detected. The following conclusions can be made: mobile spermatozoa of normal morphology can be infected with HSV; as shown morphologically, samples of ejaculate from men whose wives had spontaneous abortions contained intragametic HSV capsides; intragametic HSV infection of spermatozoa had a negative effect on the course of pregnancy and/or embryon vitality.

  11. "A study on Stress, Depression and NK Cytotoxic Potential in Women with Recurrent Spontaneous Abortion "

    Alireza alib

    2006-03-01

    Full Text Available It has been recognized that acute and chronic stress has an impact on the immune system. Acute stress may have a stimulating effect on the immune system, while in the case of chronic stress specially depression, the immune system could be down-regulated. However, an association between depression and a higher number of circulating white blood cells with increased activity has been reported. Elevation in immune cell numbers and alteration in cytokine profiles are documented for women suffering sporadic spontaneous abortion with a high stress score. In spite of these contradictory results and to make a new approach in immunological (NK activity as well as psychological parameters (stress/depression in women suffering from recurrent spontaneous abortion (RSA the present study was planned. Forty-five women with a history of RSA and a matched control group were participated in this study. A questionnaire for life events known as life change units (LCU and the Beck Depression Inventory (BDI outlines were used and the socio-psychological events were recorded after visiting and interview. Fresh peripheral blood lymphocytes were taken as a source of NK activity and K562 cell line were used as NK sensitive target. The experiments were performed and the cells were analyzed with a flow-cytometer. The stress and the depression scores were determined 245±83.6 and 27.6±8.8 for women with RSA and 224±79.6 and 19.4±7.1 for non-RSA group respectively. There was an association between life stress scores and depression scores with r=0.65 and P=0.000 for RSA women. A correlation with r = -0.34 and P = 0.02 was found between depression scores and NK cytotoxicity. The Pearson correlation test showed a lack of relationship between high stress score and NK activity with the r=0.011 and P=0.95, but r= -0.30 and P=0.072 was obtained for high depression scores and NK cytotoxicity. Therefore, it could be suggested that in the case of women with a history of recurrent

  12. Aberrant Expression of TNF-α and TGF-β1 mRNA in Spontaneous Abortion

    Ji-fen HU; Hong-chu BAO; Feng-chuan ZHU; Cai-ling YOU

    2004-01-01

    Objective To investigate the aberrant expressions of TNF-α and TGF-β1 in peripheral blood mononuclear cells (PBMCs) and placental tissues in patients with early spontaneous abortionMethods Using the technique of semi-quantitative reverse transcript-polymerase chain reaction (RT-PCR), TNF-α mRNA and TGF-β1 mRNA in PBMCs were measured in spontaneous abortion group (30 cases), normal pregnancy group (25 cases) and nonpregnant group (25 cases). The expressive intension of TNF-α protein and TGF-β1 protein in placental tissues was also identified by immunohistochemistry.Results Both levels of TNF-α mRNA and TGF-β1 mRNA expressed in PBMCs were significantly different between the three groups respectively (P<0. 05). Levels of TNF-α in syncytiotrophoblastic and cytotrophoblastic cells of the two aborted groups were substantially higher than those of the non-pregnant group (P<0. 01), but the levels of TGF-β1 in syncytiotrophoblastic cells of the two aborted groups were markedly lower than those of the non-pregnant group (P<0. 01).Conclusion There is potential relation between TGF-β1 at the fetomaternal interface and spontaneous abortion. TGF-β1 may contribute to the maintenance of pregnancy,and low-level expression of TGF-β1 may be associated with pregnancy failure.

  13. Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients

    U Shankarkumar

    2011-01-01

    Full Text Available Background: An autoimmune cause and related immunological alterations resulting in recurrent spontaneous abortion (RSA have been suggested in patients with unknown etiology. Materials and Methods: This study evaluated the autoantibody profile and other immunological parameters among RSA patients and normal pregnant women from Mumbai western India. Fifty RSA patients with unknown cause and greater than three consecutive abortions along with 50 normal pregnant women were studied for various auto antibodies such as ANA, anti-dsDNA, ANCA, AECA, 2 micro globulin, anti-HLA antibodies and ACLA using immunofluorescence microlymphocytotoxicity and ELISA. Immunological parameters such as HLA class I monoclonal antibody expression, CD3 (T cell, CD19 (B cell, and CD56 (NK cell were estimated by flow cytometry. Results: The results revealed 34% positivity of all auto antibodies tested among patients. ANA(12%, ANCA (20%, AECA (24%, ACLA (8%, anti-dsDNA(0%, β2 microglobulin (14%, and anti-HLA antibodies(10% among RSA patients were identified. An increased expression of HLA class I specific monoclonal antibody (10% with HLA A3 (16% specificity were found to correlate with shared HLA alleles among the RSA couples. Among normal pregnant (control group ANA (2%, ANCA (2%, AECA (3%, ACLA (4% and increased expression of CD56 with reduced HLA class I monoclonal were observed. Conclusion: Our findings suggest a possible role of various autoantibodies along with the related immunological parameters underlying RSA.

  14. Abortive Spontaneous Egg Activation: An Emerging Biological Threat for the Existence of Mammals.

    Prasad, Shilpa; Tiwari, Meenakshi; Chaube, Shail K

    2017-03-02

    Mammals are important for balancing the natural ecosystem, but in the past few decades, several species have rapidly been entered under threatened category worldwide. The environmental changes, loss of natural habitats, human activities, and thereby stress are responsible for a gradual decline in reproductive outcome. Stress induces generation of reactive oxygen species (ROS). High physiological level of ROS drives abortive spontaneous egg activation (SEA), while beyond the physiological level causes oxidative stress (OS). The OS induces apoptosis and deteriorates egg quality that limits reproductive outcome. The reduced reproductive outcome is one of the major causes for gradual decline in population size of several mammalian species. Despite having several conservation programs, a gradual decline in species reproductive outcome and their population size is the serious concern for the existence of threatened mammalian species. Thus, it is important to identify and prevent the underlying causes responsible for abortive SEA, which could be an emerging problem for several mammalian species that are threatened or at the verge of extinction.

  15. EFFECTS OF ANTICOAGULATION PROTEIN DEFECT IN MATERNAL PLASMA ON SPONTANEOUS ABORTION

    Chun-mei Bai; Shui-qing Ma; Ming-ying Gai; Lian-kai Fan; Feng-yan Ren; Guang-sheng Fan

    2004-01-01

    Objective To investigate the mechanism of anticoagulation protein defect in the pathogenesis of unexplained recurrent miscarriage.Methods Fifty-seven patients with a history of unexplained abortion were enrolled as the investigation group for tests of protein C, protein S, antithrombin Ⅲ (AT-Ⅲ), as well as activated protein C resistance (APC-R). The control group consisted of fifty healthy women with a history of hormal pregnancy and delivery. Blood samples were obtained for measuring serum activity of protein C, protein S, AT- Ⅲ, and APC-R. Patients with positive APC-R were tested for factor Ⅴ (FV) Leiden gene mutation by PCR-RFLP method.Results Of the 57 patients, 12 (21.1%), 1 (1.8%), and 5 (8.8%) cases were found with protein S, protein C, and AT-Ⅲdeficiency respectively, and 13 (22.8%) cases with positive results of APC-R. Of the control group, no protein C or AT-Ⅲdeficiency was ever found, whereas 2 (4.0%) volunteers were presented with protein S deficiency and 3 (6.0%) with positive results of APC-R. No FV Leiden gene mutation was identified in all the patients with positive APC-R results. Late spontaneous abortion cases had higher incidence of anticoagulation protein defect than the early cases.Conclusion Anticoagulation protein defect may play a role in the pathogenesis of fetal loss, especially for those occurring in late stage of pregnancy.

  16. Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran

    Saeedeh Ghazaey

    2015-04-01

    Full Text Available Background: Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs. The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materials and Methods: In this retrospective study, the pattern of chromosomal aberrations was evaluated during a six-year period from 2005 to 2011. The population under study was 728 couples who attended genetic counseling services for their RSAs at Pardis Clinical and Genetics Laboratory, Mashhad, Iran. Results: In this study, about 11.7% of couples were carriers of chromosomal aberrations. The majority of abnormalities were found in couples with history of abortion, without stillbirth or livebirth. Balanced reciprocal translocations, Robertsonian translocations, inversions and sex chromosome aneuploidy were seen in these cases. Balanced reciprocal translocations were the most frequent chromosomal anomalies (62.7% detected in current study. Conclusion: These findings suggest that chromosomal abnormalities can be one of the important causes of RSAs. In addition, cytogenetic study of families who experienced RSAs may prevent unnecessary treatment if RSA are caused by chromosomal abnormalities. The results of cytogenetic studies of RSA cases will provide a standard protocol for the genetic counselors in order to follow up and to help these families.

  17. Effects of sera taken from women with recurrent spontaneous abortion on sperm motility and apoptosis

    Tahereh Talaei-khozani

    2011-01-01

    Full Text Available Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities.Objective: The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility.Materials and Methods: Sera of 20 women with URSA history and sera from 20 women with at least two healthy children were added to the sperms samples from 20 healthy men for 2 hours. The sperm motility was assessed after incubation with sera. The samples were stained with Tdt mediated dUTP nick end labeling (TUNEL assay for DNA fragmentation. The samples were analyzed with flow cytometry and the percentage of the TUNEL positive sperms were calculated. The data were analyzed by t-test.Results: The incubation of the sperm samples in sera with URSA lead to a decrease in the percentage of the motile sperm from 55% in control to 41% in the treated group, significantly (p=0.038. The percentage of the sperm with abnormal fragmented DNA increased after incubation with URSA (26.6% compare to the control (21.2%; however, it was not significant.Conclusion: It seems that sera from URSA patients could not induce a significant increase in the percentage of the sperms with nuclei contain DNA fragmentation. However, the sera of women with URSA could affect the fertility rate by reduction of the sperm motility.

  18. Reduced stathmin-1 expression in natural killer cells associated with spontaneous abortion.

    Lin, Yi; Li, Cui; Shan, Bin; Wang, Wenjing; Saito, Shigeru; Xu, Jiehan; Di, Jingfang; Zhong, Yanmin; Li, Da-Jin

    2011-02-01

    Female CBA/J mice impregnated by male DBA/2J mice (CBA/J×DBA/2J matings) are prone to spontaneous abortion, although the reason for this is unclear. In this study, the stathmin-1 expression pattern was evaluated in uterine natural killer (uNK) cells purified from CBA/J×DBA/2J matings. Results were compared with those in a CBA/J×BALB/c control group that yields successful pregnancies. The mean ± SD percentage of stathmin-1(+) cells in the CD49b(+) uNK cell population was lower in CBA/J×DBA/2J mice (0.7% ± 0.4%) than in control CBA/J×BALB/c mice (4.9% ± 1.5%, P stathmin-1 level in uNK cells was lower in CBA/J×DBA/2J mice than in control mice using Western blot analysis. Co-localization of lectin from Dolichos biflorus agglutinin (DBA-lectin) and stathmin-1 was confirmed using multivision immunohistochemical analysis. The frequency of stathmin-1(+)DBA-lectin(+) cells was lower in CBA/J×DBA/2J mice than in CBA/J×BALB/c mice. A similar trend in the frequency of stathmin-1(+)CD56(+) cells was seen in patients with unexplained spontaneous abortion compared with normal early pregnancy. A neutralizing antibody against stathmin-1 further increased the percentage of embryo loss in CBA/J×DBA/2J matings. These results provide evidence that stathmin-1 expression in uNK cells at the maternal-fetal interface may help modulate uNK cell function and may be beneficial for a successful pregnancy.

  19. Determinants of pregnancy and induced and spontaneous abortion in a jointly determined framework: evidence from a country-wide, district-level household survey in India.

    Ahmed, Salma; Ray, Ranjan

    2014-07-01

    This study provides evidence on the principal determinants of pregnancy and abortion in India using a large country-wide district-level data set (DLHS 2007). The paper provides an economic framework for the analysis of pregnancy and abortion. The study distinguishes between induced and spontaneous abortion and compares the effects of their determinants. The results show that there are wide differences between induced and spontaneous abortions in terms of the sign and magnitude of the estimated effects of several of their determinants, most notably wealth, the woman's age and her desire for children. The study makes a methodological contribution by proposing a trivariate probit estimation framework that recognizes the joint dependence of pregnancy and induced and spontaneous abortion, and provides evidence in support of this joint dependence. The study reports an inverted U-shaped effect of a woman's age on her pregnancy and both forms of abortion. The turning point in each case is quite robust to the estimation framework. A significant effect of contextual variables, at the village level, constructed from the individual responses, on a woman's pregnancy is found. The effects are weaker in the case of induced abortion, and insignificant in the case of spontaneous abortion. The results are shown to be fairly robust. This paper extends the literature on the relation between son preference and fertility by examining the link between mother's son preference and desire for more children with abortion rates.

  20. Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion

    WANG Yu; ZHAO Ai-min; LIN Qi-de

    2010-01-01

    Background Experimental evidence indicates that cyclooxygenase-2 (COX-2) plays a critical role in blastocyst implantation; however, little is known of the role of COX-2 in unexplained recurrent spontaneous abortion (URSA).Methods We evaluated the expression level and potential signaling pathway of COX-2 in 30 cases of URSA who were excluded the abnormality of chromosomes, anatomy, endocrine, infectious, autoimmune diseases and in 30 normal pregnancies.Results The mRNA and the protein expression level of COX-2 in the URSA group (-0.238±0.848, 0.368±0.089,respectively) were significantly lower than that in the control group (1.943±3.845, 1.046±0.108, respectively) (both, P<0.01). The expression of prostaglandins PGF2a, PGD2, PGE2, and PGI2, in the URSA group ((2326.0±295.6) pg/ml,(2164.0±240.5) pg/ml, (238.7±26.4) pg/ml, (2337.0±263.0) pg/ml, respectively) were significantly lower than that in the control group ((3450.0±421.7) pg/ml, (3174.0±415.6) pg/ml, (323.5±43.8) pg/ml, (3623.0±460.4) pg/ml, respectively) (P<0.05). The mRNA expression level of PPARβ and RXRa (0.859±0.653, -0.172±0.752, respectively) in URSA group was significantly lower than that in the control group (1.554±1.735, 0.777±2.482, respectively) (both P <0.05). The mRNA and protein expression levels of vascular endothelial growth factor-A (VEGF-A) in the URSA group (2.010±1.522, 0.35±0.46)was significantly lower than that in the control group (4.569±2.430, 0.750±0.350) (both P <0.05).Conclusions COX-2 and the COX-2-derived PGI2 signaling pathway possibly play an important role in successful embryo implantation, and their decreased expression may result in URSA. The decreased expression may influence the expression of VEGF-A which interferes with placental angiogenesis causing failure of embryo implantation, leading to spontaneous abortion.

  1. Anti-GBM of Pregnancy: Acute Renal Failure Resolved after Spontaneous Abortion, Plasma Exchange, Hemodialysis, and Steroids

    Mohammed Muqeet Adnan; Jordan Morton; Syed Hashmi; Sufyan Abdul Mujeeb; William Kern; Benjamin Jr. Cowley

    2014-01-01

    Antiglomerular basement membrane disease presenting during pregnancy is very uncommon. We present a case of a pregnant female who presented with acute renal failure needing dialysis from Goodpasture's disease. She responded very well to just plasma exchange, high dose steroids, and hemodialysis. Cyclophosphamide was never started on this patient. She had a spontaneous abortion in her 8th week of pregnancy and henceforth did very well to regain her renal function. Patient became hemodialysis i...

  2. Spontaneous Abortion and a Diet Drug Containing Caffeine and Ephedrine: A Study within the Danish National Birth Cohort

    Howards, Penelope P.; Irva Hertz-Picciotto; Bech, Bodil H.; Nohr, Ellen A; Anne-Marie Nybo Andersen; Charles Poole; Jørn Olsen

    2012-01-01

    BACKGROUND: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort. METHODS: Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome w...

  3. Cystathionine β-synthase 844ins68 Genetic Polymorphism in Spontaneous Abortion Susceptibility

    Radu Anghel POPP

    2011-12-01

    Full Text Available Aim: Genetic polymorphisms in homocysteine-related genes are subject of a large body of research in pregnancy and newborn associated pathologies. The enzyme cystationine β-synthase (CBS is involved in the transsulfuration pathway of homocysteine to cysteine. Our objective was to analyze the association of a common polymorphism exhibited by the CBS gene, 844ins68, with idiopathic spontaneous abortions (SA. Material and Methods: 131 patients with a history of at least one unexplained SA and 135 healthy women with at least one successful pregnancy and no SA were included in a case-control study. Simplex PCR was used to genotype the cases and control volunteers for the CBS 844ins68 polymorphism. Fisher’s exact test was performed to obtain the odds-based parameters describing the relationship between the two variables. Results: The variant allele was encountered with a frequency of 0.08 in the SA group and 0.048 in controls. The dominant model analysis of risk revealed the OR 1.957, 95%CI [0.920, 4.162], Fisher’s p = 0.09. Conclusion: The findings suggest possible effects of this polymorphism in SA risk that did not reach the significance level in this study. Future studies might validate or clarify the association between CBS 844ins68 and idiopathic SA.

  4. Research of Active Immunotherapy on Unexplained Recurrent Spontaneous Abortion(URSA)

    Hong-chu BAO; Na LV; Cui-fang HAO

    2006-01-01

    Objective To investigate the effect of active immunotherapy on unexplained recurrent spontaneous abortion (URSA ) during the process of gestation and delivery period.Methods We collected the data of the women with URSA and their offsprings. The women were treated by immunization with paternal lymphocytes and then had a successful pregnancy. The fore mentioned group of women were compared with those who had a normal pregnancy and then delivered in the same period.Results The incidences of premature rupture of membranes, adherent placenta, and residual cauls in the group of URSA patients were statistically higher than those in the normal group.Correspondingly, gestational age at delivery and birth weight of the newborns of the group of URSA patients were lower,but there were no significant differences between the two groups.Conclusion These results indicate that paternal lymphocyte immunotherapy is effective on the maintenance of pregnancy in women with URSA, and has no deleterious effects on the fetus or newborns. However,in case of the higher incidence of premature rupture of membranes, adherent placenta, and residual cauls, more attention should be paid to the treated patients to avoid intrauterine growth retardation and postpartum hemorrhage.

  5. Induction of thymic tolerance as possibility in prevention of recurrent spontaneous abortion.

    Bubanovic, I V

    2003-04-01

    A major process through which the immune system becomes tolerant to self-proteins involves the deletion of self-reactive cells in the thymus and/or inhibition of specific Th(1) cells clones. Deletion process includes two selection mechanisms in which the thymus eliminates unwanted thymocytes are known as positive selection and negative selection. The thymus is an antigenically privileged site, mainly for it is discrete by blood-thymus barrier. Many researches were shown that intrathymic inoculation of any antigen resulted in specific tolerance induction. The embryo/fetus and placenta are an allograft to which the mother must remain immunologically tolerant in order for the fetus to survive. Today, there is much interest focused on the immunology of recurrent spontaneous abortion (RSA). Up to 50% of RSA may be mediated by the immune system via inadequate maternal anti-paternal response. Nature of this maternal-fetal disturbance represents disbalance in Th(1)/Th(2) activity. Contra-shift in Th(1)/Th(2) activity is the basis for immunotherapy with paternal leukocyte immunization (PLI). PLI induce some kind of peripheral tolerance on embryonic/fetal/trophoblast antigens, but problems of central tolerance are still open. Intrathymic inoculation of fetal or paternal cells (like leukocyte, thymic dendritic cells, trophoblast cells) or paternal set of MHC molecules may cause central specific tolerance and may be a new possibility for immunotherapy in RSA patients.

  6. A cytogenetic study of couples with recurrent spontaneous abortions and infertile patients with recurrent IVF/ICSI failure

    Mozdarani Hossein

    2008-01-01

    Full Text Available Purpose: This study was conducted to determine the frequency and contribution of chromosomal abnormalities in miscarriages and in couples with recurrent in vitro fertilization/intra cytoplasmic sperm injection (IVF/ICSI failure. Materials and Methods: A total of 221 individuals; 79 with three or more recurrent spontaneous abortions and 142 with at least three IVF/ICSI failures. Chromosomal analysis from peripheral blood lymphocytes was performed according to standard cytogenetic methods using G-banding technique. Results: Abnormal karyotype was found in 21 (9.50% individuals. Of these 21 subjects, 4 (19.04% exhibited sex chromosomal abnormalities and 17 (80.96% had autosomal abnormalities. Male partners had significantly higher chromosomal abnormalities (5.88% than of females (3.61%. These abnormalities were also higher in patients with recurrent spontaneous abortions than with IVF/ICSI failure (P < 0.05. Conclusions: These data may be indicative that chromosomal abnormalities are involved more in spontaneous abortions than in recurrent IVF/ICSI failure. Cytogenetic analysis could be valuable for these couples when clinical data fail to clarify the cause.

  7. Fatores Associados ao Aborto Espontâneo Recorrente Recurrent Spontaneous Abortion-associated Factors

    Ricardo Barini

    2000-05-01

    . Conclusão: para uma investigação completa dos fatores associados ao aborto espontâneo recorrente faz-se necessária a inclusão do fator aloimune, sem a qual a maior parte dos casos não terá etiologia esclarecida.Purpose: to identify recurrent spontaneous abortion- associated factors. Subjects: one hundred seventy-five outpatients were investigated from March 1993 to March 1997 at the "Ambulatório de Aborto Recorrente CAISM/UNICAMP". All of them had had three or more consecutive spontaneous abortions and/or two abortions and were 35 years or more old. Methods: the investigation protocol included: couple's karyotype; hysterosalpingography, serial plasma progesterone levels and/or endometrial biopsy; toxoplasmosis, listeriosis, brucelosis, lues and cytomegalovirus serum tests; Chlamydia trachomatis and Mycoplasma hominis cultures of cervical discharge; TSH and thyroid hormone levels; fasting glucose; autoantibody panel, anti-HLA antibody search by microlymphocytotoxicity crossmatch and one-way mixed lymphocyte culture with inhibitor factor detection. Husband's evaluation included: physical evaluation, lues, Chagas' disease, B and C hepatitis and AIDS serum tests, microlymphocytotoxicity crossmatch and one-way mixed lymphocyte culture with inhibitor factor detection. Results: alloimmune etiology was the most frequently found factor (86.3% of studied patients, represented by negative crossmatch and one-way mixed lymphocyte culture with inhibitor factor below 50%. The second most frequently found factor was cervical incompetence (22.8%, followed by hormonal factor (21.2%, mainly represented by luteal insufficiency. Some patients were found to have more than one etiologic factor. Conclusion: the investigation of recurrent spontaneous abortion-associated factors must include alloimmune etiology. Most cases will remain unexplained without this investigation.

  8. Association of HLA-DQB1 coding region with unexplained recurrent spontaneous abortion

    汪希鹏; 林其德; 陆佩华; 马政文; 赵爱民

    2004-01-01

    Background DNA analysis has shown a lack of significant compatibility between couples affected by unexplained recurrent spontaneous abortion (URSA) compared with normal fertile couples,8although one study that made use of a PCR-sequence-specific oligonucleotide (SSO) method did observe evidence of significant compatibility in the HLA-DQA1 and DQB1 alleles between patients and aborted fetuses. 9 This study was designed to investigate whether URSA were associated with particular DQ alleles or promoter alleles.Methods Thirty-two patients with URSA and 54 women who had had at least one successful pregnancy were included in this study. HLA-DQ genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The HLA-DQB1 promoter was detected by the SSO and sequence-specific primer (SSP) methods. The DQA1, DQB1, and DQB1 promoter (QBP) gene frequencies in the patients were compared with the gene frequencies in normal controls. The data were analyzed statistically with the X2 and Fisher's exact tests.Results The results showed that the frequency of DQB1 * 0604/0605 was significantly higher and the frequency of DQB1 * 0501/0502 was significantly lower in the patient group as compared with the normal controls. In addition, the frequencies of the DQA1 * 01-DQB1 * 0604/0605 and QBP6.2-DQB1 * 0604/0605 haplotypes were overrepresented in the patients relative to the controls. Our results did not show any differences between URSA patients and the controls with regard to DQA1 and QBP allele frequencies.Conclusions Our data suggest that URSA is associated with the HLA-DQB1 coding region, and is not associated with its upstream regulatory region. The DQB1 * 0604/0605, DQA1 * 01-DQB1 * 0604/0605, and QBP6.2-DQB1 * 0604/0605 haplotypes may confer susceptibility to URSA, while the DQB1 *0501/0502 allele may protect women from URSA.

  9. Molecular Detection and Genotypic Characterization of Toxoplasma gondii in Paraffin-Embedded Fetoplacental Tissues of Women with Recurrent Spontaneous Abortion

    Abdoli, Amir; Dalimi, Abdolhossein; Soltanghoraee, Haleh; Ghaffarifar, Fatemeh

    2017-01-01

    Background Congenital toxoplasmosis is an important cause of spontaneous abortion worldwide. However, there is limited information on detection and genotypic characterization of Toxoplasma gondii (T. gondii) in women with recurrent spontaneous abortion (RSA). The aim of this study is the molecular detection and genotypic characterization of T. gondii in formalin-fixed, paraffin-embedded fetoplacental tissues (FFPTs) of women with RSA that have referred to the Avicenna Research Institute in Tehran, Iran. Materials and Methods This experimental research was undertaken on 210 FFPTs of women with RSA. The information of the patients was collected from the archives of Avicenna Research Institute in Tehran, Iran. After DNA extraction, the presence of T. gondii was examined by nested polymerase chain reaction targeting the GRA6 gene. Genotyping was performed on positive samples using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) that targeted the GRA6 and SAG3 genes. Sequencing was conducted on two GRA6 positive samples. Results T. gondii DNA was detected in 3.8% (8/210) of the samples. Genotyping showed that all positive samples belonged to type III of the T. gondii genotype. Sequencing two genomic DNAs of the GRA6 gene revealed 99% similarity with each other and 99-100% similarity with T. gondii sequences deposited in GenBank. There were six patients with histories of more than three abortions; one patient had a healthy girl and another patient had two previous abortions. Abortions occurred in the first trimester of pregnancy in seven patients and in the second trimester of pregnancy in one patient. Conclusion The results of this study have indicated that genotype III is the predominant type of T. gondii in women with RSA in Tehran, Iran. Also, our findings suggest that toxoplasmosis may play a role in the pathogenesis of RSA. However, further studies are needed to elucidate a clear relationship between T. gondii infection and RSA. PMID

  10. Dynamics and reproductive effects of complement factors in the spontaneous abortion model of CBA/J×DBA/2 mice.

    Takeshita, Ai; Kusakabe, Ken Takeshi; Hiyama, Masato; Kuniyoshi, Nobue; Kondo, Tomohiro; Kano, Kiyoshi; Kiso, Yasuo; Okada, Toshiya

    2014-05-01

    The complement system is one component of innate immunity that could participate in fetal loss. We have already reported that adipsin, a complement activator in the alternative pathway, is stably expressed in the placenta and that an increase in this expression is related to spontaneous abortion. However, complement inhibitor Crry was concurrently expressed in the placenta, and the role of complement factors during pregnancy was not clear. In the present study, we examined the endogenous regulation of complement factors in placenta and serum by using another model mouse for spontaneous abortion and studied the effect of exogenous complement disruption on pregnancy. Compared to control mice, the CBA/J×DBA/2 model mice had higher expression levels of adipsin in the placenta and serum. Adipsin and complement C3 were localized in the metrial gland and labyrinth regions, and both positive reactive ranges were limited in the maternal blood current in normal implantation sites. These results suggest that extrauterine adipsin hematogenously reaches the placenta, activates complement C3, and promotes destruction of the feto-maternal barrier in aborted implantation sites. Crry was consistently expressed in the placenta and serum and reduced in the resorption sites of CBA/J×DBA/2 mice as compared to normal sites. Injection of recombinant adipsin increased the resorption rate and changed the expression of Th-type cytokines toward a Th1 bias. The present study indicates that adipsin could induce the fetal loss that accompanies the Th1 bias and may be a crucial cause of spontaneous abortion. In addition, the local expression of Crry prevents complement activation in placenta in response to a systemic increase of adipsin.

  11. Employment in the Ecuadorian cut-flower industry and the risk of spontaneous abortion

    Harlow Sioban D

    2009-10-01

    Full Text Available Abstract Background Research on the potentially adverse effects of occupational pesticide exposure on risk of spontaneous abortion (SAB is limited, particularly among female agricultural workers residing in developing countries. Methods Reproductive histories were obtained from 217 Ecuadorian mothers participating in a study focusing on occupational pesticide exposure and children's neurobehavioral development. Only women with 2+ pregnancies were included in this study (n = 153. Gravidity, parity and frequency of SAB were compared between women with and without a history of working in the cut-flower industry in the previous 6 years. Logistic regression analysis was conducted to assess the relation between SAB and employment in the flower industry adjusting for maternal age. Results In comparison to women not working in the flower industry, women working in the flower industry were significantly younger (27 versus 32 years and of lower gravidity (3.3 versus 4.5 and reported more pregnancy losses. A 2.6 (95% CI: 1.03-6.7 fold increase in the odds of pregnancy loss among exposed women was observed after adjusting for age. Odds of reporting an SAB increased with duration of flower employment, increasing to 3.4 (95% CI: 1.3, 8.8 among women working 4 to 6 years in the flower industry compared to women who did not work in the flower industry. Conclusion This exploratory analysis suggests a potential adverse association between employment in the cut-flower industry and SAB. Study limitations include the absence of a temporal relation between exposure and SAB, no quantification of specific pesticides, and residual confounding such as physical stressors (i.e., standing. Considering that approximately half of the Ecuadorian flower laborers are women, our results emphasize the need for an evaluating the reproductive health effects of employment in the flower industry on reproductive health in this population.

  12. Double and multiple chromosomal aneuploidies in spontaneous abortions: A single institutional experience

    Shivakumar Subramaniyam

    2014-01-01

    Full Text Available Objective: To characterize double and multiple aneuploidies in spontaneous abortions (SAB. Materials and Methods: Retrospective analysis of cytogenetics data obtained by culturing/harvesting products of the conception material at our center from 2006 to 2009 was performed. The abnormal cytogenetic results, maternal age, gestational age, and previous pregnancy history were recorded and compared. Results: Double and multiple aneuploidies are rare, however, a high percentage of double (4.6% and multiple (0.4% chromosomal aneuploidies were observed in our study of 1502 cases of SAB. Of 1502 cases of SAB evaluated, 70 cases (4.6% showed double aneuploidy, whereas 6 cases (0.4% had multiple aneuploidies. The chromosomes most frequently involved in double aneuploidy in the decreasing order were 21, 16, ± X, 22, 18, 13, and 15. The most frequent chromosome combinations observed were: Loss of X/21 (8.5%, 21/22 (4.4%, 16/21 (4.4%, and 7/16 (4.4%. The chromosome combinations in multiple aneuploidy included trisomy of chromosomes X/5/8, 8/20/22, 16/20/22, 14/21/22, and loss of X with 21/21 and 7/21. These abnormalities were significantly observed in women between the age group 40-44 years (59.2%. A high success rate (94% of obtaining metaphase cells was observed in this study mainly due to the use of direct and long-term cultures. Conclusions: We observed a high percentage of double (4.6% and multiple (0.4% aneuploidies, frequently involving the acrocentic chromosomes 13, 15, 21, and 22 and nonacrocentric chromosomes X, 16, and 18.

  13. Abnormal T-Cell Reactivity against Paternal Antigens in Spontaneous Abortion: Adoptive Transfer of Pregnancy-Induced CD4+CD25+ T Regulatory Cells Prevents Fetal Rejection in a Murine Abortion Model

    Zenclussen, Ana Claudia; Gerlof, Katrin; Zenclussen, Maria Laura; Sollwedel, André; Bertoja, Annarosa Zambon; Ritter, Thomas; Kotsch, Katja; Leber, Joachim; Volk, Hans-Dieter

    2005-01-01

    Mammalian pregnancy is thought to be a state of immunological tolerance. The mechanisms underlying this phenomenon are still poorly understood. Here, we determined whether an inappropriate function of T regulatory (Treg) cells is involved in the pathogenesis of spontaneous abortion. We evaluated spleen and decidual lymphocytes from CBA/J mice undergoing immunological abortion (DBA/2J-mated) or having normal pregnancy (BALB/c-mated) on day 14 of gestation for ex vivo cytokine production after ...

  14. Cytogenetic Evaluation of Couples With Spontaneous Abortion, Still Birth and Recurrent Miscarriage in Qazvin: Report and Review

    Najafipour

    2016-03-01

    Full Text Available Background Chromosomal abnormality plays an important role in different types of miscarriages. Objectives The present study was designed to investigation chromosomal anomalies in three groups of couples with recurrent abortion (RA, spontaneous abortion (SA and still birth (SB. Patients and Methods In this retrospective study, the frequency of chromosomal aberrations was investigated among 260 couples with miscarriage, which had referred to the cytogenetic section of a reference laboratory in Buali hospilal, Qazvin, Iran from 2009 to 2014. Metaphase spreads were analyzed using G-banding. Results In this study, 7.6% of couples had chromosomal aberrations including, balanced reciprocal translocations, robertsonian translocations, inversions and sex chromosome aneuploidy. Frequency of balanced translocations was higher, specifically in couples with SA. Conclusions In this investigation we showed that chromosomal abnormalities could be one of the important causes of miscarriages. Cytogenetic evaluation of couples, which experienced different types of miscarriage, may prevent unnecessary treatments.

  15. [Does shift work cause spontaneous abortion, preterm birth or low birth weight?].

    Schlünssen, Vivi; Viskum, Sven; Omland, Øyvind; Bonde, Jens Peter

    2007-03-05

    In Denmark 30% of females in the reproductive age regularly have shift work. 22 epidemiological papers were studied looking at associations between shift work and abortion, stillbirth, preterm birth, and birth weight. No convincing associations were observed between rotating shift work or fixed nightshift and negative pregnancy outcome. Some epidemiological support was found for a relation between fixed nightshift and late abortions/stillbirth. If fixed night work for all pregnant women is avoided, seven late abortion/stillbirths a year can be prevented. Fixed night work for pregnant women should be avoided.

  16. HLA allele associations in idiopathic recurrent spontaneous abortion patients from India

    U Shankarkumar

    2008-01-01

    Full Text Available Background : Rejection of semiallogenic foetus in recurrent spontaneous abortion (RSA has been postulated to be a consequence of genetic and immunological phenomena. Aim: To evaluate the role of human leukocyte antigen (HLA alleles in RSA in Indian couples. Settings and Design : A case-control study. Materials and Methods : Eighty-one randomly selected couples with unexplained three or more RSAs and a control group of 97 couples with live birth belonging to the same ethnic background, referred to the Gynaecology Department, KEM Hospital were included in the case-control study. Serological HLA A and B typing was done followed by molecular subtypes, defined using PCR-SSOP technique for HLA A, B, and C in 40 couples and DRB1FNx01 and DQB1FNx01 in 28 couples which were then compared with appropriate case 46 and 88 controls. Results : Serologically A3 (15.43% vs . 4.43%; odds ratio (OR = 4.34; P = 0.0002 and B17 (25.3% vs . 11.34%; OR = 3.49; P = 0.0001 were increased. Haplotype A1-B17 was significantly increased. Molecular subtyping revealed that AFNx01030102 (11.25% vs . 4.34%; OR = 3.00; P = 0.07, BFNx015701 (11.25% vs . 1.08%; OR = 13.10; P = 0.003, CwFNx01120201 (25% vs . 4.34%; OR = 10.50; P = 2.05E-05, HLA DRB1FNx01030101 (17.85% vs . 3.40%; OR = 7.6; P = 0.0001, DRB1FNx01150101 (32.14% vs . 13.63%; OR = 4.8; P = 0.0003, and DQB1FNx01060101 (35.71% vs . 29.34%; OR = 2.3; P = 0.004 were significantly increased in patients. A differential association was noticed when compared with reported world RSA patients. Conclusion: The HLA alleles AFNx01030101, BFNx015701, CwFNx01120201, DRB1FNx01030101, and DRB1FNx01150101 as well as their associated ancestral haplotype may play a significant role in development of RSA in India.

  17. Presence of antibodies against Coxiella burnetii and risk of spontaneous abortion: a nested case-control study.

    Stine Yde Nielsen

    Full Text Available BACKGROUND AND AIMS: Q fever is a bacterial zoonosis caused by infection with Coxiella burnetii. It is well established that Q fever causes fetal loss in small ruminants. The suspicion has been raised that pregnant women may also experience adverse pregnancy outcome when the infection is acquired or reactivated during pregnancy. The purpose of this study was to assess the potential association between serologic markers of infection with C. burnetii and spontaneous abortion. METHODS: A nested case-control study within the Danish National Birth Cohort, a cohort of 100,418 pregnancies recruited from 1996-2002. Women were recruited in first trimester of pregnancy and followed prospectively. Median gestational age at enrolment was 8 weeks (25 and 75 percentiles: 7 weeks; 10 weeks. During pregnancy, a blood sample was collected at gestational week 6-12 and stored in a bio bank. For this study, a case sample of 218 pregnancies was drawn randomly among the pregnancies in the cohort which ended with a miscarriage before 22 gestational weeks, and a reference group of 482 pregnancies was selected in a random fashion among all pregnancies in the cohort. From these pregnancies, serum samples were screened for antibodies against C. burnetii in a commercial enzyme-linked immunosorbent assay (ELISA. Samples that proved IgG or IgM antibody positive were subsequently confirmatory tested by an immunofluorescence (IFA test. RESULTS: Among cases, 11 (5% were C. burnetii positive in ELISA of which one was confirmed in the IFA assay compared to 29 (6% ELISA positive and 3 IFA confirmed in the random sample. CONCLUSIONS: We found no evidence of a higher prevalence of C. burnetii antibodies in serum samples from women who later miscarried and the present study does not indicate a major association between Q fever infection and spontaneous abortion in humans. Very early first trimester abortions were, however, not included in the study.

  18. A Case–control Study on the Relationship between Mycoplasma genitalium Infection in Women with Normal Pregnancy and Spontaneous Abortion using Polymerase Chain Reaction

    Ramazanzadeh, Rashid; Khodabandehloo, Mazaher; Farhadifar, Fariba; Rouhi, Samaneh; Ahmadi, Amjad; Menbari, Shaho; Fallahi, Fariba; Mirnejad, Reza

    2016-01-01

    Objectives Mycoplasma genitalium infections are suggested as causes of a number of pathological outcomes in pregnant women. The aim of this study was to evaluate the frequency of M. genitalium infections among pregnant women and its association with spontaneous abortion. Methods In this case–control study we included 109 women with spontaneous abortion with a gestational age of 10–20 weeks (patients), and 109 women with normal pregnancy with a gestational age of 20–37 weeks (controls) in Sana...

  19. Evaluation of Th1 and Th17 cells cytokines in cell culture stimulated in women with recurrent spontaneous abortion

    Y Varghaiyan

    2013-10-01

    Full Text Available Introduction: Various immunological abnormalities have been reported in women with RSA of unknown aetiologies including autoimmune abnormalities and increased cellular immunity such as elevated natural killer (NK , Th1 and Th17 cell levels. Th17 and Th1 cells play a central role during inflammation. Th1 cells product cytokines IFN-γ, IL-2 and Th17 cells mainly cytokines IL-17A, F, IL-22. The aim of this study is evaluation of Th1 and Th17 activity in women with recurrent spontaneous abortion. Methods: In this case-control study, 30 women with history of two or more abortion who at least 3 months past after last abortion considered as case group and 30 normal fertile healthy women with at least one delivery as control group. We determined the levels of IL-17A, F and IFN-γ in cell culture supernatant of peripheral blood mononuclear cells (PBMC stimulated with the mitogen phytohemagglutinin (PHA by enzyme-linked immunosorbent assay (ELISA method and compared in the two groups. The results obtained using the one-sample kolmogorov-smirnov Test, Kruskal-wallis Test and Spearman were analyzed using SPSS 16 software. Results: The level of IFN- γ in case group was significantly higher than control group (186/53±30/41 versus 88/06±21/44 pg/ml, P < 0.005. Also the level of IL-17 A, F in case group was significantly higher than control group (84/74±21/26 versus 28/41±8 pg/ml, P < 0.01. IFN-γ concentration showed positive correlation with IL-17 A, F in case group (P=0.015, r= 0.455. Conclusion: In this study the increased levels of cytokines IFN- γ and IL-17 A, F in women with recurrent spontaneous abortion shows a propensity of pro inflammation via Th17 and Th1 immunity and may be these cells play a pivotal role in rejecting fetus antigens.

  20. Association between Spontaneous abortion and Presence of anti thyroid antibodies in mother’s serum

    Mahmoud Mirhosseini

    2012-12-01

    Results: Out of 51 subjects, 18 had positive Anti-TPO-Ab, of which -10 were among the cases and 8 belonged to the controls. Out of 18 women with positive AntiTG-Ab, 11 cases were in the control group and 7 were in the cases. The differences between the control group and the amounts of Anti-TPO-Abs (P=0.468 and Anti-TG-Abs (P=0.675 were not swignificant. Conclusion: The results revealed that there is no association between abortion and presence of antithyroid antibodies in mother’s serum. Other abortion causes such as various kinds of infections and smoking might be involved which requires more research.

  1. T-HELPER 1 CYTOKINES INCREASE DURING EARLY PREGNANCY IN WOMEN WITH A HISTORY OF RECURRENT SPONTANEOUS ABORTION

    A. Rezaei A. Dabbagh

    2000-08-01

    Full Text Available The measurment of various cytokines may provide a different tool for evaluation of the immune system. Recent investigations have shown that the number and function of peripheral natural killer cells (NK- cells increase during early pregnancy in women with a history of unexplained recurrent spontaneous abortions (RSA. NK-cells activity may be responsible for some cases of RSA. The objective of this study was to assess the role of the Thl cytokines (IL-2, IFN-y, TNF-a ; TNF-/0 in this phenomenon, and detection of Thl cytokines in women with RSA. The control group consisted of 40 women with no history of pregnancy loss and complication. The abortion group comprised of 92 women having at least 3 pregnancy losses. Blood from the control group and women with RSA was taken at the end of first trimester of gestational age and at the time of abortion, respectively. Sera were separated and peripheral blood lymphocytes were challenged with PHA using RPMI medium. All samples were tested for concentration of Thl cytokines using ELISA methods. It was considered that sera from women with RSA produced higher concentration of TNF-«, TNF-/? , and IL-2 in comparison with sera from normal pregnant women (NPW (P<0.001. We were not able to detect IL-2 in (NPW whereas in 31% sera from RSA group, IL-2 was detectable (P<0.001. However, there was no significant difference between IFN-y, concentration in sera from patients and control group (P<0.182. Tissue culture supernatant from women with RSA also produced higher concentration of TNF-a. IFN-y, TNF-/* and IL2, than control group. These data may explain the increase NK-cells cytotoxicity during early pregnancy in women with a history of RSA. It may also provide a diagnostic tool to predict the outcome of pregnancy.

  2. Expression of Vascular Endothelial Growth Factor in Embryos of Spontaneous Abortion and Induced Abortion%血管内皮生长因子在自然流产胚胎和人工流产胚胎中的表达

    袁秀英; 韩临晓; 刘燕燕; 黄丽娥; 刘小媚

    2012-01-01

    Objective To explore the expression differences of vascular endothelial growth factor (VEGF) in embryos of spontaneous abortion and induced abortion. Methods According to gestational age, 80 women with abortion were divided into two groups. Immunohistochemistry was used to observe the expression of VEGF in embryonic villi of 30 cases of spontaneous abortion (patient group) and 50 cases of induced abortion (control group). Results Among different gestational ages, the expression of VEGF in patient group was lower than that of control group. The expression of VEGF in control group was increased with the gestational age, but the same trend was not observed in patient group. Conclusions Among the same gestational age, the expression of VEGF in embryonic villi of spontaneous abortion was declined as compared with that in induced abortion. The decreased expression of VEGF may be associated with spontaneous abortion.%目的 探讨自然流产胚胎和人工流产胚胎中血管内皮生长因子(VEGF)表达量的差异. 方法 按照孕周分组,采用免疫组化法检测30例自然流产胚胎(病例组)绒毛组织中VEGF的表达,同时收集50例人工流产的胚胎绒毛组织(对照组)检测VEGF进行对照分析研究. 结果 在不同的孕周,病例组其VEGF的表达量均较对照组降低,且对照组VEGF的表达量随着孕周的增加而增加,在病例组中却没有这样的趋势. 结论 自然流产的胚胎组织与同孕周的人工流产的胚胎组织相比其VEGF表达量下降,提示VEGF表达量下降可能与自然流产相关.

  3. Small supernumerary marker chromosomes derived from chromosomes 6 and 20 in a woman with recurrent spontaneous abortions.

    Guediche, Narjes; Tosca, Lucie; Nouchy, Marc; Lecerf, Laure; Cornet, Dominique; Brisset, Sophie; Goossens, Michel; Tachdjian, Gérard

    2012-12-01

    In this report, we describe a case of multiple small supernumerary marker chromosomes (sSMC) presenting with recurrent abortions. Peripheral blood lymphocytes of a young, healthy and non-consanguineous couple who asked for genetic evaluation after two spontaneous miscarriages were obtained for karyotypes. Lymphocytes of the woman were analyzed by FISH techniques and DNA was extracted and used for array CGH investigation. Karyotyping revealed 48,XX,+2mar[24]/47,XX,+mar[5]/46,XX[3] for the woman and 46,XY for her husband. FISH analysis showed that the two sSMC consisted of chromosomes 6 and 20. Array CGH analysis showed gains of the 6p11.2q12 (9 Mb) and 20 p11.21 (3.3 Mb) chromosomal regions with a total of 42 genes present on both sSMC. Our findings support also the hypothesis that the modification of the expression of some genes involved in embryo implantation, like THBD gene, could be responsible in the recurrent abortions. This report underpins the necessity of array CGH for characterizing precisely sSMC and helping in genotype-phenotype correlations. Furthermore, a literature review on sSMC is included.

  4. Killer cell immunoglobulin-like receptor gene associations with autoimmune and allergic diseases, recurrent spontaneous abortion, and neoplasms

    Piotr eKusnierczyk

    2013-01-01

    Full Text Available Killer cell immunoglobulin-like receptors (KIRs are a family of cell surface inhibitory or activating receptors expressed on natural killer cells and some subpopulations of T lymphocytes. KIR genes are clustered in the 19q13.4 region and are characterized by both allelic (high numbers of variants and haplotypic (different numbers of genes for inhibitory and activating receptors on individual chromosomes polymorphism. This contributes to diverse susceptibility to diseases and other clinical situations. Associations of KIR genes, as well as of genes for their ligands, with selected diseases such as psoriasis vulgaris and atopic dermatitis, rheumatoid arthritis, recurrent spontaneous abortion, and non-small cell lung cancer are discussed in the context of NK and T cell functions.

  5. Relationships between mild PM10 and ozone urban air levels and spontaneous abortion: clues for primary prevention.

    Di Ciaula, Agostino; Bilancia, Massimo

    2015-01-01

    The effects of environmental pollution on spontaneous abortion (SAB) are still unclear. Records of SAB were collected from five cities (514,996 residents) and correlated with PM10, NO(2) and ozone levels. Median pollutant concentrations were below legal limits. Monthly SABs positively correlated with PM10 and ozone levels but not with NO(2) levels. The mean monthly SAB rate increase was estimated equal to 19.7 and 33.6 % per 10 μg/m(3) increase in PM10 or ozone concentration, respectively. Higher values of PM10 and SABs were evident in cities with- than in those without pollutant industries, with a number of SABs twofolds higher in the former group. In conclusion, SAB occurrence is affected by PM10 (particularly if industrial areas are present) and ozone concentrations, also at levels below the legal limits. Thus, SAB might be considered, at least in part, a preventable condition.

  6. Relationship between the Abnormal Expression of FasL on Human First Trimester Trophoblast and Spontaneous Abortion

    邱红玉; 孙永玉

    2003-01-01

    In order to study the molecular immune-pathological mechanism of spontaneous abortion (SA), immunohistochemistry techniques were used to detect the FasL expression of first trimester trophoblast in the SA patients and normal controls. High precise color-image measure system for immuno-histochemistry (HPIS) was used to determine the quantity of FasL expression. The results showed that the scale and intensity of FasL expression on the trophoblasts in SA group were significantly lower than in the control group. It is indicated that abnormal expression of FasL on trophoblasts, which damages the immunological tolerance between mother and fetus, may be one of the important mechanisms of development of SA. To induce the expression of FasL or to regulate the immunological tolerance will be a new way to treat SA.

  7. 内分泌异常与复发性流产%Endocrine Abnormalities and Recurrent Spontaneous Abortion

    李倩; 梁晓燕

    2013-01-01

    The recurrent miscarriage is traditionally defined as three or more consecutive pregnancy losses before 20 weeks. The causes of recurrent spontaneous abortion are not clear,including genetic factors, uterine abnormalities,immunologic and endocrine factors,infections,and unexplained abortion. The endocrine disorders is related to recurrent miscarriage, including disorders of both reproductive glands and other glands. This article discussed the relationships between recurrent spontaneous abortion and endocrine disorders such as luteal insufficiency,thyroid dysfunction,hyperprolactinemia,insulin resistance and hyperandrogenism. However, it needs more study to understand the mechanism of recurrent miscarriage caused by endocrine abnormalities.%复发性流产是指在妊娠20周前,连续发生2次或以上自然流产。复发性流产的病因目前尚未明确,主要包括遗传因素、解剖异常、内分泌异常、感染、免疫因素及不明原因的复发性流产。其中内分泌异常与复发性流产密切相关,无论是生殖腺分泌功能异常或其他相关内分泌腺体分泌异常,都有可能导致复发性流产的发生。从黄体功能不足、甲状腺功能异常、高催乳素血症、胰岛素抵抗及高雄激素血症等方面,探讨内分泌异常与复发性流产之间的相关性。内分泌异常会导致复发性流产,但是其具体机制仍需要进一步探索。

  8. Citogenética y aborto espontáneo Cytogenetics and spontaneous abortion

    Bernardo Agudelo Jaramillo; Gonzálo Vásquez Palacio; Carlos Mario Muñeton Peña; José Luis Ramírez Castro

    1998-01-01

    En este artículo se presentan algunos aspectos relacionados con el aborto espontáneo de etiología cromosómica, haciendo énfasis en los diversos tipos de alteraciones, su frecuencia, su expresión fenotípica y las técnicas modernas de diagnóstico citogenético. This article presents some important issues related with spon~neous abortion with chromosomal aberratiens. The diverse types of alterations along with their frequency, phenotypical expression and modern diagnostic techniques are discussed...

  9. Cytogenetics and spontaneous abortion Citogenética y aborto espontáneo

    Bernardo Agudelo Jaramillo

    1998-04-01

    Full Text Available This article presents some important issues related with spon~neous abortion with chromosomal aberratiens. The diverse types of alterations along with their frequency, phenotypical expression and modern diagnostic techniques are discussed. En este artículo se presentan algunos aspectos relacionados con el aborto espontáneo de etiología cromosómica, haciendo énfasis en los diversos tipos de alteraciones, su frecuencia, su expresión fenotípica y las técnicas modernas de diagnóstico citogenético.

  10. Cytogenetics and spontaneous abortion Citogenética y aborto espontáneo

    Bernardo Agudelo Jaramillo; Gonzálo Vásquez Palacio; Carlos Mario Muñeton Peña; José Luis Ramírez Castro

    1998-01-01

    This article presents some important issues related with spon~neous abortion with chromosomal aberratiens. The diverse types of alterations along with their frequency, phenotypical expression and modern diagnostic techniques are discussed. En este artículo se presentan algunos aspectos relacionados con el aborto espontáneo de etiología cromosómica, haciendo énfasis en los diversos tipos de alteraciones, su frecuencia, su expresión fenotípica y las técnicas modernas de diagnóstico citogenético...

  11. Array-based comparative genomic hybridization is more informative than conventional karyotyping and fluorescence in situ hybridization in the analysis of first-trimester spontaneous abortion

    Gao Jinsong

    2012-07-01

    Full Text Available Abstract Background Array-based comparative genomic hybridization (aCGH is a new technique for detecting submicroscopic deletions and duplications, and can overcome many of the limitations associated with classic cytogenetic analysis. However, its clinical use in spontaneous abortion needs comprehensive evaluation. We used aCGH to investigate chromosomal imbalances in 100 spontaneous abortions and compared the results with G-banding karyotyping and fluorescence in situ hybridization (FISH. Inconsistent results were verified by quantitative fluorescence PCR. Results Abnormalities were detected in 61 cases. aCGH achieved the highest detection rate (93.4%, 57/61 compared with traditional karyotyping (77%, 47/61 and FISH analysis (68.9%, 42/61. aCGH identified all chromosome abnormalities reported by traditional karyotyping and interphase FISH analysis, with the exception of four triploids. It also detected three additional aneuploidy cases in 37 specimens with ‘normal’ karyotypes, one mosaicism and 10 abnormalities in 14 specimens that failed to grow in vitro. Conclusions aCGH analysis circumvents many limitations in traditional karyotyping or FISH. The accuracy and efficiency of aCGH in spontaneous abortions highlights its clinical usefulness for the future. As aborted tissues have the potential to be contaminated with maternal cells, the threshold value of detection in aCGH should be lowered to avoid false negatives.

  12. Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model.

    Zenclussen, Ana Claudia; Gerlof, Katrin; Zenclussen, Maria Laura; Sollwedel, André; Bertoja, Annarosa Zambon; Ritter, Thomas; Kotsch, Katja; Leber, Joachim; Volk, Hans-Dieter

    2005-03-01

    Mammalian pregnancy is thought to be a state of immunological tolerance. The mechanisms underlying this phenomenon are still poorly understood. Here, we determined whether an inappropriate function of T regulatory (Treg) cells is involved in the pathogenesis of spontaneous abortion. We evaluated spleen and decidual lymphocytes from CBA/J mice undergoing immunological abortion (DBA/2J-mated) or having normal pregnancy (BALB/c-mated) on day 14 of gestation for ex vivo cytokine production after PMA or paternal antigen (alloantigen) stimulation. Treg activity was characterized by quantifying CD4(+)CD25(+) cells, foxp3 expression, and interleukin-10 secretion. Decidual lymphocytes from abortion CBA/J mice contained a significantly higher frequency of interferon-gamma-producing T cells specific for paternal antigens compared to those from normal pregnancy (7.8% versus 2.7%, P abortion mice. Very interestingly, CD4(+)CD25(+) Treg cells from normal pregnant and nonpregnant CBA/J mice could inhibit both proliferation and interferon-gamma secretion of lymphocytes from abortion mice in vitro whereas in vivo prevention of fetal rejection could only be achieved after adoptive transfer of Treg cells from normal pregnant mice. Our data suggest that pregnancy-induced Treg cells play a vital role in maternal tolerance to the allogeneic fetus.

  13. T-helper 1-type immunity to trophoblast in patients with recurrent spontaneous abortion

    2001-01-01

    Objective:To test the hypothesis that peripheral blood mononuclear cells (PBMCs) in women with unexplained recurrent abortion (URA) produce T-helper 1 (Th1)-type cytokines in response to trophoblastantigens. Methods: A total of 25 women with URA and 15 reproductively normal parous control women participated the study. Supernatants from trophoblast-activatied PBMCs from all participants were tested by enzyme-linked immunosorbent assay(ELISA) for Th1-type cytokines [interleukin-2 (IL-2), interferon gamma(IFN-γ)] and Th2-type cytokines (IL-4,IL-10). Results: The levels of IL-2, IFN-γ in trophoblast-activitated PBMCs supernatants from URA patients were highr than those from reproductively normal women (P<0.05). In contrast, the supernatants from URA patients contained lower Th2-type cytokines (IL-4,IL- 10) (P<0.05). Conclusions: Whereas Th1-type immunity to trophoblast is assoicated withURA and may play a role in reproductive failure, Th2-type immunity may a natural response to trophoblast contributing to successful pregnancy.

  14. Study of miR-155 expression in villus tissue of patients with recurrent spontaneous abortion and its relationship with apoptosis molecules and angiogenesis molecules

    Hong-Ying Du; Man-Zhen Zuo; Qiao-Ling Wang; Xiao-Juan Xie

    2016-01-01

    Objective:To study miR-155 expression in villus tissue of patients with recurrent spontaneous abortion and its relationship with apoptosis molecules and angiogenesis molecules.Methods:40 cases of patients with unexplained recurrent spontaneous abortion were selected as URSA group, 30 cases of normal early pregnant women receiving artificial abortion were selected as control group, and villus tissue was collected to detect expression levels of miR-155, apoptosis molecules (Bcl-2, Bcl-xl, Bax, Bad, Fas and FasL) and angiogenesis molecules (HIF-1α, VEGF and sFlt-1).Results: MiR-155 expression level in villus tissue of URSA group was significantly lower than that of control group and the more the times of abortion, the lower the miR-155 expression level; pro-apoptosis molecules Bax, Bad, Fas and FasL expression levels in villus tissue of URSA group were higher than those of control group and negatively correlated with miR-155 expression level, and anti-apoptosis genes Bcl-2 and Bcl-xl expression levels were lower than those of control group and positively correlated with miR-155 expression level; HIF-1α and VEGF expression levels in villus tissue of URSA group were lower than those of control group and positively correlated with miR-155 expression level, and sFlt-1 expression level was higher than that of control group and negatively correlated with miR-155 expression level.Conclusions:MiR-155 is lowly expressed in villus tissue of patients with recurrent spontaneous abortion, and miR-155 may be involved in the occurrence and development of the disease through regulating the expression of apoptosis molecules and angiogenesis molecules.

  15. Occupational risk factors of spontaneous abortion in medical personnel%医务人员自然流产职业危险因素

    杨蕾

    2016-01-01

    近几年,在医务人员中,发生自然流产的事件越来越多,医务人员由于其工作的特殊性,在工作过程中存在着较多的危险因素,本文分析医务人员自然流产职业危险因素,为临床提供探讨。%In recent years,in medical personnel,spontaneous abortions are more and more,due to the particularity of the work in medical staff,there are many risk factors in the course of the work.In this paper,the author analysed the occupational risk factors of spontaneous abortion in medical personnel,to provide discuss for clinic.

  16. Treg/Th17 Cell Imbalance and IL-6 Profile in Patients With Unexplained Recurrent Spontaneous Abortion.

    Zhu, Liqiong; Chen, Hui; Liu, Meilan; Yuan, Yu; Wang, Zhaohua; Chen, Ying; Wei, Jing; Su, Fang; Zhang, Jianping

    2016-10-02

    Regulatory T cells (Treg) and T helper 17 cells (Th17) are 2 distinct subsets of CD4(+) T cells, which are mutually antagonistic in the immune response. Recently, dysregulation of these 2 cell subsets have been described in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). The purpose of this study was to investigate whether the Treg/Th17 balance was perturbed in URSA patients and to explore contributing factors. We found that the proportion of Treg cells and expression of forkhead box P3 (Foxp3) messenger RNA (mRNA) were significantly lower in URSA patients than in healthy controls. However, the proportion of Th17 cells and expression of retinoid-related orphan nuclear receptor-γt (ROR-γt) mRNA were higher in URSA patients than in controls, revealing inverse correlation with Treg. The ratio of Treg/Th17 and Foxp3/ROR-γt decreased in patients with URSA compared to healthy controls. The serum levels of interleukin (IL)-6 and IL-17A were significantly higher, whereas IL-10 was lower in URSA patients compared with controls, and the level of IL-6 showed a positive correlation with Th17, ROR-γt and inverse correlation with Treg, Foxp3. The present study indicated that an imbalance between Treg and Th17 cells might be implicated in the pathogenesis of URSA and this seems to relate to elevation in serum IL-6 level.

  17. Spontaneous abortion and a diet drug containing caffeine and ephedrine: a study within the Danish national birth cohort.

    Penelope P Howards

    Full Text Available BACKGROUND: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen containing ephedrine (20 mg and caffeine (200 mg with spontaneous abortion (SAB in the Danish National Birth Cohort. METHODS: Women were recruited during their first prenatal visit from 1996-2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB. PRINCIPAL FINDINGS: The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6 for any periconceptional Letigen use compared to no periconceptional use. CONCLUSIONS: Although Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee, periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.

  18. Early detection of Toxoplasma gondii by real-time polymerase chain reaction methods in patients with recurrent spontaneous abortions

    Parviz Saleh

    2014-11-01

    Full Text Available Introduction: One of the causes of recurrent spontaneous abortions (RSA is an infection by the toxoplasmosis Protozoa. In comparison, we present detailed results using real-time polymerase chain reaction (PCR methods of detection. In this study, it was tried to detect Toxoplasma gondii (T. gondii by real-time PCR methods in patients with RSA. Methods: Amniotic fluid sampling was performed in the 16-20th weeks of gestation in 50 pregnant women with a history of RSA. The extracted deoxyribonucleic acid (DNA samples were analyzed using quantitative real-time PCR. Results: In all the cases, the detection of T. gondii was negative in the peripheral blood, and amniotic fluid samples by using the molecular methods (real-time PCR. Using the serological detection methods, 6% of patients were diagnosed as positive for the immunoglobulin M (IgM antibody. In addition, the IgG antibody was positive in 46% of the patients. Conclusion: It can be concluded that the serological methods lack specificity.

  19. 1483例自然流产患者细胞遗传学分析%Cytogenetic analysis of 1483 patients with spontaneous abortion

    傅文婷; 刘舒; 潘小英

    2010-01-01

    目的 应用染色体核型分析技术对自然流产患者进行遗传学分析,探讨其临床表型与异常染色体核型的关系.方法 2008年在我院行外周血染色体检查的患者总计4010例,其中自然流产患者1483例,对其进行染色体核型分析.结果 染色体核型分析1483例自然流产患者中,共发现平衡易位携带者32例.结论 对自然流产患者的染色体检查,可以对优生优育起到指导作用,避免和预防遗传性疾病传给下一代.%Objective Conducting the genetic analysis of the patients with spontaneous abortion with karyotyping.Method In 2008, there were 4010 patients conducted karyotyping, and 1438 of them have the case history of spontaneous abortion. Result In the 1483 patients, we found 32balanced translo-cation carrier.Conclusion Conducting the karyotyping analysis of the patients with spontaneous abortion may give guidance and instruction to the eugenics,and can prevent the delivery of hereditary disease to the offspring.

  20. Relationship between expression of chemokine receptors CCR3,CCR5 and CXCR3 on CD4+ T cells and spontaneous abortion in mice

    JIANG Pei-juan; LIN Qi-de; BAO Shi-min; ZHAO Ai-min; ZHANG Yu; XIAO Shi-jin

    2009-01-01

    Background Previous studies have shown that local immune cells in the feto-maternal interface are recruited from peripheral blood, and that chemokines and their receptors play an initial and key role in this recruitment process. In this study, we aimed to determine whether spontaneous abortion is associated with the expression of chemokine receptors CCR3, CCR5, and CXCR3 on CD4+ T cells.Methods Peripheral blood, spleen, and thymus were collected from the spontaneous abortion mouse model CBA/J×DBN2 (SA group, n=14), the normal pregnant mouse model CBA/J×BALB/c (NP group, n=13), and normal non-pregnant CBA/J mice (NNP group, n=11). The number of chemokine receptors CCR3, CCR5, and CXCR3 expressed on CD4+ T cells was measured by double-label flow cytometry (FCM) method.Results In peripheral blood, the SA group had significantly lower CCR3 expression (P 0.05). In spleen, the SA group expressed significantly lower CCR3 expression (P 0.05). In thymus, the SA group had significantly lower CCR3 expression (P 0.05). Compared with the NNP group, the SA group had higher CCR3 expression (P 0.05) between the two groups.Conclusion The abnormal expression of CCR3, CCR5 and CXCR3 on CD4+ T cells may play an important role in the pathogenesis of spontaneous abortion.

  1. Circadian Clock Gene Plays a Key Role on Ovarian Cycle and Spontaneous Abortion

    Ruiwen Li

    2015-09-01

    Full Text Available Background/Aims: Circadian locomotor output cycles protein kaput (CLOCK plays a key role in maintaining circadian rhythms and activation of downstream elements. However, its function on human female reproductive system remains unknown. Methods: To investigate the potential role of CLOCK, CLOCK-shRNAs were transfected into mouse 129 ES cells or injected into the ovaries of adult female mice. Western blotting was utilized to analyze the protein interactions and flow cytometry was used to assess apoptosis. Results: The expression of CLOCK peaked at the 6th week in the healthy fetuses. However, an abnormal expression of CLOCK was detected in fetuses from spontaneous miscarriage. To determine the effect of CLOCK on female fertility, a small hairpin RNA (shRNA strategy was used to specifically knockdown the CLOCK gene expression in vitro and in vivo. Knockdown of CLOCK induced apoptosis in mouse embryonic stem (mES cells and inhibited the proliferation in mES cells in vitro. CLOCK knockdown also led to decreased release of oocytes and smaller litter size compared with control in vivo. Conclusions: Collectively, theses findings indicate that CLOCK plays an important role in fertility and that the CLOCK knockdown leads to reduction in reproduction and increased miscarriage risk.

  2. Abortion, Miscarriage, and Breast Cancer Risk

    ... of Breast & Gynecologic Cancers Breast Cancer Screening Research Abortion, Miscarriage, and Breast Cancer Risk: 2003 Workshop In ... cancer risk, including studies of induced and spontaneous abortions. They concluded that having an abortion or miscarriage ...

  3. Prevalence and diversity of Arcobacter spp. isolated from the internal organs of spontaneous porcine abortions in Denmark

    On, Stephen L.W.; Jensen, Tim Kåre; Bille-Hansen, Vivi

    2002-01-01

    aborted fetuses from a single sow. The high prevalence of arcobacters in Danish pig abortions may account for at least some of the >90% of cases in which no established abortifacient agent is detected, but further studies are needed to define the role of each species, especially where co...... to examine pooled tissue samples for Campylobacter, Arcobacter and Helicobacter spp. Routine microbiological, immunological, and histopathological examinations were also performed to identify concurrent infections or histopathological change. The abortions tested negative for established abortifacient...

  4. Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes.

    Derek E Wildman

    Full Text Available BACKGROUND: Preterm birth is a leading cause of perinatal mortality, yet the evolutionary history of this obstetrical syndrome is largely unknown in nonhuman primate species. METHODOLOGY/PRINCIPAL FINDINGS: We examined the length of gestation during pregnancies that occurred in a captive chimpanzee colony by inspecting veterinary and behavioral records spanning a total of thirty years. Upon examination of these records we were able to confidently estimate gestation length for 93 of the 97 (96% pregnancies recorded at the colony. In total, 78 singleton gestations resulted in live birth, and from these pregnancies we estimated the mean gestation length of normal chimpanzee pregnancies to be 228 days, a finding consistent with other published reports. We also calculated that the range of gestation in normal chimpanzee pregnancies is approximately forty days. Of the remaining fifteen pregnancies, only one of the offspring survived, suggesting viability for chimpanzees requires a gestation of approximately 200 days. These fifteen pregnancies constitute spontaneous abortions and preterm deliveries, for which the upper gestational age limit was defined as 2 SD from the mean length of gestation (208 days. CONCLUSIONS/SIGNIFICANCE: The present study documents that preterm birth occurred within our study population of captive chimpanzees. As in humans, pregnancy loss is not uncommon in chimpanzees, In addition, our findings indicate that both humans and chimpanzees show a similar range of normal variation in gestation length, suggesting this was the case at the time of their last common ancestor (LCA. Nevertheless, our data suggest that whereas chimpanzees' normal gestation length is ∼20-30 days after reaching viability, humans' normal gestation length is approximately 50 days beyond the estimated date of viability without medical intervention. Future research using a comparative evolutionary framework should help to clarify the extent to which

  5. Study of methyl transferase (G9aMT) and methylated histone (H3-K9) expressions in unexplained recurrent spontaneous abortion (URSA) and normal early pregnancy.

    Fatima, Nishat; Ahmed, S H; Salhan, Sudha; Rehman, S M F; Kaur, Jatinder; Owais, M; Chauhan, Shyam S

    2011-11-01

    We investigated the expression of methyl transferase G9a and methylated histone H3-K9 in fresh human decidual/endometrial tissue of 12 normal early pregnancies and 15 unexplained recurrent spontaneous abortions (URSA). The samples were obtained through dilatation and curettage and collected as per strict inclusion-exclusion criteria. The tissue was subjected to immunohistochemical analysis (IHC), western blotting (WB) and RT-PCR analysis. The results demonstrated methyl transferase G9a to have a lower expression in abortions when compared with that in normal pregnancy (P K9 was significantly lower (P < 0.0001) in URSA tissues than in controls. This study suggests that methylation may cause URSA and indicates the need for further work to explore the role of methylation in URSA and its possible prevention through locally acting methylating/demethylating agents.

  6. 自然流产408例危险因素分析%Analysis of the risk factors of spontaneous abortion in 408 cases

    赵雪芬; 王静

    2016-01-01

    Objective:To investigate the causes and influencing factors of spontaneous abortion for providing the basis in formulating the control measures, guiding prepotency and maternal and child health care. Methods:Four hundred and eight patients with spontaneous abortion and 461 puerperas with normal pregnancy and labor were divided into the case group and control group according to the case-control study. The risk factors in two groups were investigated and analyzed. Results:One way ANOVA analysis showed that the age,profession,vaginal bleeding during pregnancy,family history of early pregnancy,pregnancy complications,folic acid application, pregnancy times and history of abnormal pregnancy were the influencing factors of spontaneous abortion(P <0. 01). Multivariable logistic regression analysis showed that the age, clothing profession, chemical profession, beauty salon profession, building decoration profession,vaginal bleeding during pregnancy, family history of early pregnancy, folic acid use, reproductive tract infection, viral influenza,pregnancy times and history of abnormal pregnancy were the independent factor of spontaneous abortion. Conclusions:The age,clothing profession,chemical profession,beauty salon profession,building decoration profession,vaginal bleeding during pregnancy, family history of early pregnancy,infection during pregnancy,pregnancy times and history of abnormal pregnancy are the independent factors of spontaneous abortion,and the folic acid is a protective factor of spontaneous abortion.%目的::研究自然流产发生原因及影响因素,为制定防治对策,指导优生优育及妇幼卫生保健提供依据。方法:采用病例对照研究方法,选择408例自然流产者作为病例组,同期选择正常妊娠分娩的产妇461名作对照组,调查可能的危险因素,并进行统计学分析。结果:单因素分析显示,年龄、职业、孕期阴道流血及保胎史、早孕家装史、妊娠期合并症

  7. 人微小病毒B19感染与自然流产的关系%Relationship between human parvovirus B19 and spontaneous abortion

    刘元元; 简子娟; 高骞; 彭婉婵; 谷秀梅; 刘文恩

    2011-01-01

    目的 通过分析自然流产与正常妊娠晚期待产孕妇人微小病毒B19(HPV B19)DNA及IgM抗体检测情况,探讨HPV B19与自然流产的关系.方法 采集自然流产孕妇(观察组,28例)与正常待产孕妇(对照组,33例)的静脉血,以聚合酶链反应(PCR)法检测HPV B19 DNA,酶联免疫吸附试验(ELISA)检测HPV B19 IgM抗体.结果 观察组HPV B19 DNA阳性率为28.57%(8/28),对照组为9.09%(3/33),两组HPV B19 DNA阳性率比较,差异有统计学意义(x2=3.98,P<0.05).观察组检测出1例(3.57%,1/28)HPV B19 IgM抗体阳性,对照组未检测到阳性者(0.00%).结论 自然流产孕妇HPV B19感染率高于妊娠晚期待产孕妇,推测HPV B19感染可能是导致自然流产的原因之一.%Objective To investigate the relationship between human parvovirus B19 and spontaneous abortion by detecting human parvovirus B19 DNA and IgM of women in normal pregnancy and spontaneous abortion. Methods The blood of women in abortion (observation group, 28 cases) and normal pregnancy (control group, 33 cases)were collected, human parvovirus B19 DNA and IgM were detected with PCR and ELISA. Results The positive rate of human parvovirus B19 DNA was 28. 57% (8/28) in observation group and 9. 09% (3/33) in control group,there was significant difference between two groups(x2 = 3. 98, P<0. 05); human parvovirus B19 IgM was detected in one sample of observation group (3. 57%, 1/28), positive samples were not detected in the control group (0. 00%). Conclusion Human parvovirus B19 infection rate is higher in women of spontaneous abortion than in normal pregnant women, suggesting that human parvovirus B19 infection may be one of the causes leading to abortion.

  8. Cell-free fetal DNA and cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy.

    Ji Hyae Lim

    Full Text Available BACKGROUND: Cell-free fetal DNA and cell-free total DNA in maternal circulation have been proposed as potential markers for noninvasive monitoring of the placental condition during the pregnancy. However, the correlation of and change in cell-free fetal DNA and cell-free total DNA in spontaneous abortion (SA with fetal chromosomal aneuploidy have not yet been reported. Therefore, we investigated cell-free fetal DNA and cell-free total DNA levels in SA women with fetal chromosomal aneuploidy. METHODOLOGY/PRINCIPAL FINDINGS: A nested case-control study was conducted with maternal plasma collected from 268 women in their first trimester of pregnancy. Subjects included 41 SA with normal fetal karyotype, 26 SA with fetal chromosomal aneuploidy, and 201 normal controls. The unmethylated PDE9A gene was used to measure the maternal plasma levels of cell-free fetal DNA. The GAPDH gene was used to measure the maternal plasma levels of cell-free total DNA. The diagnostic accuracy was measured using receiver-operating characteristic (ROC curves. Levels of cell-free fetal DNA and cell-free total DNA were significantly higher in both SA women with normal fetal karyotype and SA women with fetal chromosomal aneuploidy in comparison with the normal controls (P<0.001 in both. The correlation between cell-free fetal DNA and cell-free total DNA levels was stronger in the normal controls (r = 0.843, P<0.001 than in SA women with normal karyotype (r = 0.465, P = 0.002 and SA women with fetal chromosomal aneuploidy (r = 0.412, P = 0.037. The area under the ROC curve for cell-free fetal DNA and cell-free total DNA was 0.898 (95% CI, 0.852-0.945 and 0.939 (95% CI, 0.903-0.975, respectively. CONCLUSIONS: Significantly high levels of cell-free fetal DNA and cell-free total DNA were found in SA women with fetal chromosomal aneuploidy. Our findings suggest that cell-free fetal DNA and cell-free total DNA may be useful biomarkers for the prediction of SA

  9. Quantification of urinary chorionic gonadotropin in spontaneous abortion of pre-clinically recognized pregnancy: method development and analytical validation.

    Reis, M Fátima; Aniceto, Pedro; Aguiar, Pedro; Simão, Filipa; Segurado, Susana

    2007-05-01

    Determination of environmental impacts on reproductive health and specifically on the incidence of early spontaneous abortion requires accurate estimates of the latter. This negative reproductive outcome can be detected by the pattern of elevation and decline of human chorionic gonadotropin (hCG) levels near and shortly beyond the expected time of implantation, requiring daily biomonitoring of hCG levels during the relevant period of the menstrual cycle. Prospective pregnancy studies to assess effects of potentially toxic exposures on human reproductive outcomes can involve up to three menstrual cycles and a huge number of samples in each, for the quantification of the inherently very low hCG levels usually can be determined only in serum. The invasive nature of blood collection, the number of samples needed for the development of prospective studies, and the lack of quantitative methods for the determination of low hCG levels in urine point to the need for collecting urine rather than blood and make it imperative to develop suitable quantitative methods for biomonitoring of very low levels of hCG in urine. This paper describes the development and validation procedures of an automated solid-phase two-site chemiluminescent immunometric assay for the quantification of urinary hCG in early pregnancy and early pregnancy loss. For the validation, both undiluted and diluted urine and control samples have been prepared. From the results, it can be concluded that the assay has a calibration range that extends to 5000 mIU/ml, with a detection limit of approximately 1.2 mIU/ml, practically identical to that found by the IMMULITE 2000 manufacturer's validation study. The intra- and inter-assay precision ranges up to a maximum of around 7%, meaning that the practical limit for functional sensitivity can be established as low as 10%. This means that the immunoassay from DPC can identify, with relatively high confidence, non-pregnant women and the typical "rise and fall" pattern

  10. Maternal MTHFR polymorphisms and risk of spontaneous abortion Polimorfismos maternos MTHFR y riesgo de aborto espontáneo

    María del Rosario Rodríguez-Guillén

    2009-02-01

    Full Text Available OBJECTIVE: To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA according to the maternal methylenetetrahydrofolate reductase (MTHFR polymorphisms (677 C>T and 1298 A>C. MATERIAL AND METHODS: We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire. Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC. RESULTS: Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (OR 677TT vs. CC/CT=5.0; 95% CI: 1.2, 20.9 and OR 1298 AC vs. AA=5.5; 95% CI: 1.1, 26.6. CONCLUSIONS: Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins.OBJETIVO: Evaluar la asociación entre aborto espontáneo (AE y el consumo dietético de vitaminas B en mujeres mexicanas portadoras de los polimorfismos de la metilentetrahidrofolato reductasa (MTHFR (677 C>T y 1298 A>C. MATERIAL Y MÉTODOS: Mediante un diseño de casos y controles anidados en una cohorte, se comparó la ingesta dietética materna de vitaminas B y folato, los polimorfismos maternos de la MTHFR y la concentración sérica de homocisteina de 23 casos de AE ( 20 semanas. RESULTADOS: Las portadoras de los genotipos MTHFR 677TT y 1298AC presentaron un incremento significativo en el riesgo de AE (RM 677TT vs. CC/CT=5.0; IC 95%: 1.2, 20.9 RM 1298 AC vs. AA=5.5; IC95%: 1.1, 26.6, respectivamente. CONCLUSIONES: Nuestros resultados apoyan el papel de la mutación de la MTHFR como posible factor de riesgo para el AE, independientemente del consumo de vitaminas B.

  11. Abortion - medical

    Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion ... A medical, or nonsurgical, abortion can be done within 7 weeks from the first day of the woman's last ...

  12. Analysis on the causes of spontaneous abortion of pregnant women in Yimeng mountain area%沂蒙山区孕妇自然流产原因分析

    杨淑兰; 姜开福; 高辉花; 王开英; 公晓琳; 赵军; 崔海霞

    2011-01-01

    Objective: To explore the incidence and main causes of spontaneous abortion in Yimeng mountain ares.Methods:Random cluster sampling method was used in the study, the related data of the cases with spontaneous women and their husbands in Yimeng mountain area from January 1, 2006 to June 30, 2008 were analyzed by retrospective epidemiological survey.Results: The incidence of spontaneous abortion in Yimeng mountain area was 1.5%.The effect factors of spontaneous abortion included living environment, occupation and educational level of pregnant women, the age, educational level, smoking and drinking habits of their husbands, suffering from diseases now and anamnesis, the histories of abnormal pregnancy and abortion; having a fever during first trimester of pregnancy, contacting pets during second and third trimester of pregnancy could induce spontaneous abortion.Conclusion: The histories of abnormal pregnancy and abortion are the main risk factors of spontaneous abortion; the pregnant women with high educational level have low incidence of spontaneous abortion.%目的:探讨沂蒙山区自然流产的发生率及自然流产的主要原因.方法:采用随机整群抽样,进行回顾性流行病学调查,对沂蒙山区2006年1月1日~2008年6月30日发生的自然流产夫妇的相关资料进行分析.结果:沂蒙山区的自然流产率为1.5%.孕妇本人居住环境、职业、文化程度及配偶年龄、文化程度、吸烟嗜好,孕妇现患病、既往患病、既往异常妊娠流产史可影响自然流产的发生;孕早期发烧,孕早期、孕中期接触宠物等可导致自然流产.结论:既往异常妊娠流产史是主要的自然流产的危险因素;孕妇文化程度越高,自然流产发生率越低.

  13. 肥胖在流产中的作用研究新进展%Obesity and Spontaneous Abortion

    2014-01-01

    妊娠妇女肥胖与流产之间的关系日益受到关注。对于因不孕接受治疗的女性,肥胖者发生流产的机会增加。肥胖女性应在体质量得到有效控制后再考虑妊娠;对于自然妊娠的女性,肥胖亦会增加流产风险。多数研究表明,肥胖导致的内分泌功能紊乱是引发流产的主要机制,肥胖患者多数存在高胰岛素血症及胰岛素抵抗(IR),其中Ⅰ型纤溶酶原激活剂抑制物(PAI-1)、雄激素、胰岛素样生长因子等分别在发病机制中起不同作用。另外,子宫内膜容受性降低、子宫内膜血流减少、染色体核型异常等也是肥胖导致流产的原因。综述肥胖在流产中的作用机制。%Gestational obesity and correlative abortion are becoming the focus. In those infertile women, obese women have higher risk of abortion. So, obese women are suggested to control well their weight before pregnancy. In those women with natural pregnancy, obese women have also increased risk of abortion. Most studies showed that the endocrine disorders related with obesity were the main mechanism of abortion. Most obese patients are accompanied with hyperinsulinism and insulin resistance, while the plasminogen activator inhibitor-1 (PAI-1), androgen and insulin-like growth factor play different roles in the pathophysiology. In addition, the decreased uterine receptivity, the reduced endometrial blood flow and abnormal karyotype are reasons of abortion in obese women. In this paper, the mechanism of abortion in obese women was reviewed.

  14. 甲状腺抗体阳性对复发性流产的影响%Effect of Positive Thyroid Antibody on Recurrent Spontaneous Abortion

    陈锦霞

    2015-01-01

    目的 探讨甲状腺抗体阳性对复发性流产的影响. 方法 整群选取在2011年5月-2014年5月期间该院收治的有自然流产史但处于非孕期的妇女103例为观察组,在同一时间段内选取有正常分娩史的非孕期妇女 97例为对照组,用化学发光法检测两组妇女血清中甲状腺球蛋白抗体(TgAb)和甲状腺过氧化物酶抗体(TPOAb),研究甲状腺抗体阳性对复发性流产的影响. 结果 观察组妇女血清中甲状腺自身抗体 (TA) 总阳性率21.36%、TgAb阳性率15.53%和TPOAb阳性率17.48%均高于对照组10.31%、5.15%、6.19%,差异有统计学意义(P0.05);而观察组妇女血清中TPOAb定量值(0.94±0.41)高于对照组(0.73±0.26),差异有统计学意义(P0.05). The serum quantitative value of TPOAb was much higher in the observation group than that in the control group [(0.94±0.41) vs (0.73±0.26)] (P<0.05). The three variables, positive TA, positive TgAb and positive TPOAb, only positive TPOAb until the end, and the TPOAb positive ratio in the observation group was 3.51 times higher than that in the control group. Conclusion Thyroid antibody has correlation with recurrent spontaneous abortion. The positive rate of thyroid antibody increases significantly in women with recurrent spontaneous abortion, which is worthy of clinical reference in the prevention and treatment of recurrent spontaneous abortion.

  15. PREGNANCY OUTCOME FOLLOWING ABORTION

    Annapurna

    2015-10-01

    Full Text Available The previous two or three induced - were spontaneous abortion will carry a risk of preterm, ectopic pregnancy. This is to study is to evaluate the outcome of pregnancy with history of previous abortion. MATERIAL AND METHODS : This study was conducted for on e and half year period in Regional Institute of Medical Sciences, Imphal, Manipur. RESULTS: We observed that majority of the women in the study fell in 25 to 35 years of age. 116 (71.9% women with history of induced abortion were aged between 25 to 30 yea rs of age. 52(73.3% women with history of spontaneous abortions were less than 30 years of age. There were only 7(9.7% women in the spontaneous abortion group who were above 35 years of age. CONCLUSION: We concluded that women with previous history of tw o or three induced abortions were at risk of preterm birth, very preterm birth and low birth weight babies in the subsequent pregnancies. The risk of caesarean was found to be increased in women with previous two or three spontaneous abortions exposing the women to the morbidity associated with the C-section

  16. Research Advances in the Etiology of Recurrent Spontaneous Abortion%复发性自然流产的病因研究进展

    王永霞

    2012-01-01

    Recurrent spontaneous abortion ( RSA ) has complicated etiology, with chromosomal abnormality being the most common cause. Anatomical factors including uterine malformation and cervix function may also play a role. Immunological studies have shown that some RSA with unknown reasons may be caused by immune factors. Some infections in the gential tract are also regarded as the causes of early abortion. Furthermore, endocrine disorders, environmental effects, and some unknown factors can also cause RSA. This article reviews these possible etiologies of RSA, with an attempt to improve the prevention of this condition.%复发性自然流产的发病机制十分复杂,染色体异常是最常见原因;其余还有解剖因素,包括子宫畸形、宫颈功能不全等;随着免疫学发展,发现部分不明原因性自然复发性流产还与免疫因素有关;有些生殖道感染也被认为是早期流产原因之一;另外,还有内分泌系统失调、环境影响、不明原因等.本文就上述病因做作一综述,为预防复发性自然流产提供进一步研究的依据.

  17. Increasing the risk of spontaneous abortion and major malformations in newborns following use of serotonin reuptake inhibitors during pregnancy: A systematic review and updated meta-analysis

    Nikfar Shekoufeh

    2012-11-01

    Full Text Available Abstract Selective serotonin reuptake inhibitors (SSRIs are the most frequently used antidepressants during pregnancy. There are conflicting results about their influence on pregnancy outcomes. The goal of this study was to update our previous meta-analysis about pregnancy outcomes following exposure to SSRIs. For this purpose, all relevant databases were searched from 1990 to March 2012 for studies investigating the pregnancy outcomes following exposure to any therapeutic dosage of any SSRI (fluoxetine, paroxetine, citalopram, escitalopram, sertraline, fluvoxamine during pregnancy. Types of outcome investigated were spontaneous abortion, major malformations, cardiovascular malformations, and minor malformations. A total of 25 studies met our criteria and were included in the meta-analysis. The odds ratio (OD values are 1.87 (95% CI: 1.5 to 2.33, P

  18. Correlation between the mutation of embryo hemoglobin genes and spontaneous abortion.%胚胎血红蛋白基因变异与早期自然流产的相关性研究

    苏秀梅; 游泽山; 李珠玉; 吴再归

    2012-01-01

    Objective; To investigate the association between the fetal hemoglobin (ε /ζ genetic variants and early spontaneous abortion. Methods; Embryonic villi DNA was extracted from 40 embryo samples of early spontaneous abortion ( spontaneous abortion group ) and 35 embryo samples of artificial abortion ( artificial abortion group) ; then PCR-sequencing was carried out for detection of mutations for the three exons , some introns and the upstream regulatory sequence point fragments. Result; No mutation had been found in the all 3 extron segments in the screened genes of s or ζ among the villus tissues. A 4bp inserted sequence locating in the 58th locus was found in the first intron of the s gene, still no significant difference in this genotypic distribution between the two groups . However, the genotypic frequency of a 58bp inserted sequence found in the 128th locus in the first intron of the ζ gene was revealed with significantly higher frequency in spontaneous abortion group ( P 0.05).两组部分胚胎绒毛组织血红蛋白ζ基因第一内含子128位点处发现58 bp插入序列,自然流产组血红蛋白ζ基因58 bp插入基因型频率高于对照组(P<0.05),关联性分析提示该基因片段变异与早期自然流产相关(r=0.26,P0.05).结论:胚胎基因血红蛋白ζ基因第一内含子第128位点处存在一58 bp插入变异,该变异与早期自然流产相关.

  19. Abortion - surgical

    Suction curettage; Surgical abortion; Elective abortion - surgical; Therapeutic abortion - surgical ... Surgical abortion involves dilating the opening to the uterus (cervix) and placing a small suction tube into the uterus. ...

  20. The balance of the immune system between HLA-G and NK cells in unexplained recurrent spontaneous abortion and polymorphisms analysis.

    Arjmand, Fateme; Ghasemi, Nasrin; Mirghanizadeh, Seyed Ali; Samadi, Morteza

    2016-06-01

    Human leukocyte antigen (HLA)-G is involved in immunoregulatory processes and particularly in pathogenesis of inflammatory disorders such as recurrent spontaneous abortions (RSA). The purpose of the current study was to examine whether two single nucleotide polymorphisms (SNPs) of HLA-G gene (rs1736936 and HLA-G*0105N) influence susceptibility to recurrent spontaneous abortion. Genomic DNA from 117 RSA patients and 117 normal fertile control individuals was isolated using the salted out method. The two single nucleotide polymorphisms in HLA-G gene were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Differences between the two groups were analyzed by SPSS19 software using Chi-square test. The results revealed a significant increase in HLA-G*0105N allele in the proportion of whole group of RSA women compared with fertile controls (P value = 0.015), OR (95 % CI) = 2.054 (1.798-2.347), as well as an absence of homozygosity for HLA-G*0105N in the study population. No significant difference was observed between the RSA and the fertile groups in terms of alleles and genotypes frequency of rs1736936 (P value = 0.323), OR (95 CI %) = 1.056 (0.844-1.319). The presented data suggest that the investigated HLA-G*0105N allele is potentially associated with RSA through linkage disequilibrium with other genetic elements. Meanwhile, the rs1736936 SNP do not predispose to RSA in the study population.

  1. Increasing the Risk of Spontaneous Abortion and Major Malformations in Newborns Following Use of Serotonin Reuptake Inhibitors during Pregnancy: a Systematic Review and Updated Meta-Analysis

    Mohammad Abdollahi

    2012-11-01

    Full Text Available Selective serotonin reuptake inhibitors (SSRIs are the most frequently used antidepressants during pregnancy. There are conflicting results about their influence on pregnancy outcomes.The goal of this study was to update our previous meta-analysis about pregnancy outcomes following exposure to SSRIs. For this purpose, all relevant databases were searched from 1990 to March 2012 for studies investigating the pregnancy outcomes following exposure to any therapeutic dosage of any SSRI (fluoxetine, paroxetine, citalopram, escitalopram, sertraline, fluvoxamine during pregnancy. Types of outcome investigated were spontaneousabortion, major malformations, cardiovascular malformations, and minor malformations. A total of 25 studies met our criteria and were included in the meta-analysis. The odds ratio (OD values are 1.87 (95% CI: 1.5 to 2.33, P< 0.0001 for spontaneous abortion, 1.272 (95%CI: 1.098 to 1.474, P = 0.0014 for major malformations, 1.192 (95% CI: 0.39 to 3.644, P=0.7578 for cardiovascular malformations, and 1.36 (95% CI: 0.61 to 3.04, P= 0.4498 for minor malformations. The results demonstrated that SSRIs increase the risk of spontaneousabortion and major malformations during pregnancy while they don’t increase the risk of cardiovascular malformations and minor malformations. Our previous meta-analysis only showed an increase in the risk of spontaneous abortion following the use of SSRIs duringpregnancy. This might be due to increase in the number of studies included or addition of two new SSRIs (citalopram and escitalopram. The message to researchers is to try considering SSRIs individually during pregnancy to reduce heterogeneity, although all are aware ofinevitable limitations to study on pregnant mothers.

  2. The Effect of Lymphocyte Immunotherapy on CD80+ Cells at the Fetomaternal Interface and Cyesis Result of Mice Model of Spontaneous Abortion

    林羿; 曾耀英; 何贤辉; 曾山; 詹美意; 关洁宾; 狄静芳; 肇静娴; 全世明

    2001-01-01

    Objectives To explore the relationship between CD80 expression on lymphocytes at the fetomaternal interface and the fertility characteristics in CBA/J × DBA/2 mice as a model of recurrent spontaneous abortion (RSA) and to investigate the effects of lym phocyte immunotherapy (LIT) on the level of CD80 expression.Materials & Methods The characteristics of fertility in CBA/J × DBA/2 mice were observed in a 120-day period and compared with four normal fertile groups. In anoth er 15 pairs of CBA/J × DBA/2 breedings, resorption rate on day 13 of pregnancy were calculated and the proportion of CD80+ cells at the fetomaternal interface were determined by using two-color flow cytometric analysis, mainly stained with CD80 FITC and CD45-PE. In order to determine the identity of CD80+ cells, the expression levels of CD3(T cell marker), DX 5(NK cell marker), and MHC-Ⅱ(antigen present ing cell marker) were detected in this cell population. Furthermore, the resorption rate and the proportion of CD80+ cells among CBA/J × DBA/2 breedings with and with out immunotherapy were also determined and compared with normal fertile controls.Results The characteristics of abortion in CBA/J × DBA/2 mice were recurrent abor tion on about day 10 of gestation. The resorption rate in CBA/J × DBA/2 mice was significantly higher than that in BALB/c×DBA/2 mice (30. 8% ± 16. 6% vs. 7. 7%± 6. 7%, P< 0. 01). Accordingly, the proportion of CD80+ cells evaluated at the fetomaternal interface in CBA/J × DBA/2 mice was also significantly higher (11. 7%± 5. 8% vs. 3. 9% ± 1. 8%, P< 0. 01). Resorption rate of CBA/J × DBA/2 mice un derwent of LIT was significantly lower than that without LIT, and this decreased rate was correlated with decreased proportion of CD80+ cells.Conclusion In CBA/J × DBA/2 mice model, the characteristics of abortion seem to be peri-implantation embryo-resorption. A correlation between early embryonic waste and higher CD80 proportion at the fetomaternal interface

  3. Cytogenetic analysis of 232 couples with at least twice spontaneous abortions in Anhui province%安徽省232对两次以上自然流产夫妇的细胞遗传学分析

    刘晓颖; 水玉云; 练作宸; 沈彤

    2001-01-01

    Objective To investigate causes of spontaneous abor tion by cytogenetic analysis. Methods Analyzing G-band chromosome s by use of lymphocytes from human peripheral blood statistically. Result s Chromosomal aberrations were important causes of spontaneous abortion, es pe cially big Y-chromosome. Conclusion It is important to examine th e chromosomal karyotypes for couples with history of spontaneous abortion, or de ad embryos. The result also suggests that to prevent abortion blindly for women with unexplained abortion should be avoided.%目的探讨自然流产夫妇细胞遗传学特点。方法用人体外周血淋巴细胞培养法,进行染色体G带分析,并进一步进行统计学分析。结果染色体畸变是自然流产的一个重要原因,且大Y是其重要方面。结论对不明原因的自然流产、死胎等异常孕产史夫妇进行染色体检查具有重要意义,同时研究结果提示对不明原因的先兆流产不要盲目保胎。

  4. Análise citogenética em material de abortamento espontâneo Cytogenetic analysis of material from spontaneous abortion

    Daniel Lorber Rolnik

    2010-01-01

    Full Text Available OBJETIVO: Descrever as anormalidades cromossômicas em material de abortamento espontâneo. MÉTODOS: Realizou-se compilação retrospectiva da análise de cariótipo em lâmina corada com Banda G por microscopia óptica e em material de 428 produtos de abortamento encaminhados para estudo. RESULTADOS: Foram observados 145 resultados normais (33,9% e 237 resultados anormais (55,4%. Em 46 amostras não houve crescimento celular (10,7%. As anormalidades numéricas foram as mais frequentes, destacando-se a trissomia do 16 (41 casos, a triplodia (27 casos, a monossomia do X (26 casos, a tetraploidia (13 casos e a trissomia do 15 (13 casos. CONCLUSÃO: As alterações citogenéticas representam importante causa de perdas gestacionais e sua detecção auxilia o aconselhamento genético do casal. A trissomia do cromossomo 16 é a alteração mais frequentemente encontrada.OBJECTIVE: To describe chromosomal abnormalities in spontaneous abortion material. METHODS: A retrospective compilation of karyotype analysis of slides stained with Band G was carried out by optical microscopy with materials of 428 abortion products referred for study. RESULTS: There were 145 normal results (33.9% and 237 abnormal results (55.4%. In 46 samples there was no cell growth (10.7%. Numerical abnormalities were the most frequent, especially trisomy 16 (41 cases, triplodia (27 cases, monosomy X (26 cases, tetraploidy (13 cases and trisomy 15 (13 cases. CONCLUSION: Cytogenetic alterations are an important cause of pregnancy loss and their detection helps the genetic counseling to the couple. Trisomy 16 is the most often found change.

  5. 早期自然流产与环境因素的相关性分析%Association between early spontaneous abortion and environmental factors

    石波; 施雯慧

    2011-01-01

    目的 探讨与早期自然流产相关的环境危险因素,为降低自然流产率、减少不良妊娠结局的发生提供参考.方法 采用问卷调查的方式,分析比较了97例在厦门市妇幼保健院诊断为早期自然流产的妇女和76例同期正常分娩的妇女的个人史资料和早孕期环境接触情况.结果 单因素分析显示,自然流产组妇女的妊娠次数、既往自然流产次数、早孕期被动吸烟、每日手机通话次数以及使用染发剂的比例显著高于对照组(P均<0.05).多因素分析显示,以上提到的三个环境接触因素均可增加早期自然流产的危险.结论 早孕期被动吸烟、每日手机通话次数以及使用染发剂均与自然流产有一定关联,因此孕妇在怀孕期间应尽量避免被动吸烟、长时间使用电磁辐射大的设备以及接触染发剂等化学物质.%Objective: Explore the environmental risk factors of early spontaneous abortion, so as to reduce the percent of miscarriage and Occurrence of adverse pregnancy outcome. Methods: Use standard questionnaires to investigate 97 women who were diagnosed as early spontaneous abortion in Hospital of Women and Children of Xiamen and 76 women who give birth normally in the same hospital during the same period, compare their medical records and information of exposure to environment during early pregnancy. Results: One-factor analysis shows that there existed differences between the case group and the control group on pregnant times, times of miscarriage, times of cell phone use per day, passive smoking, and usage of hair-dyes (P <0. 05). Multi-factors analysis shows that all the three environmental factors are risk factors of spontaneous abortion. Conclusion: Passive smoking, times of cell phone use per day, and usage of hair-dyes are related with miscarriage, pregnant women should avoid passive smoking, hair coloring and using electric equipments such as cell phone, microwave ovens for long time.

  6. Abordagem citogenética e molecular em material de abortos espontâneos Cytogenetic and molecular evaluation of spontaneous abortion samples

    Andréa Cristina de Moraes

    2005-09-01

    Full Text Available OBJETIVOS: avaliar o desempenho da citogenética e das técnicas de hibridização in situ fluorescente (FISH e reação em cadeia da polimerase (PCR no estudo das aneuploidias cromossômicas numéricas e na determinação do sexo fetal em amostras de abortos espontâneos. MÉTODOS: duzentos e dezenove amostras de produtos de abortos espontâneos foram submetidas a estudo citogenético. Deste total, 40 amostras foram também submetidas à técnica de PCR-nested para a determinação do sexo fetal: 32 foram selecionadas devido à falha de crescimento no estudo citogenético e oito foram escolhidas ao acaso. Vinte amostras foram selecionadas para detecção de aneuploidias cromossômicas pela técnica de FISH, utilizando-se sondas para os cromossomos 13, 18, 21, X e Y: 13 casos foram submetidos a FISH devido à falha de crescimento no estudo citogenético e sete foram escolhidos ao acaso. Foi calculada a taxa de sucesso (obtenção de cariótipo de cada técnica. Para comparação das taxas de sucesso foi utilizado o teste de chi2, sendo considerados significantes resultados com pPURPOSE: to evaluate the performance of cytogenetic analysis, fluorescent in situ hybridization (FISH and polymerase chain reaction (PCR in the study of numerical chromosomal anomalies and in fetal sex determination of spontaneous abortion material. METHODS: cytogenetic analysis was performed on 219 spontaneous abortion specimens. Forty of these cases were also submitted to fetal sex determination using nested-PCR. Thirty-two of these cases were selected due to failed cytogenetic culture and the other eight were selected randomly. Twenty samples were submitted to the FISH technique, using probes for chromosomes 13, 18, 21, X and Y. Thirteen of these samples were selected due to failed cytogenetic culture and the other seven were randomly selected. The success rates of each technique were compared using the chi2 test and an established p<0.05 level of significance. The

  7. FISH技术在检测自然流产绒毛染色体异常中的应用研究%Application of fluorescence in situ hybridization in detecting chromosomal abnormalities of spontaneous abortion

    蒲育栋; 苏焕厚; 曹金如; 陈美玲; 邓汉钊; 何淑贞

    2016-01-01

    Objective:To explore the value of fluorescence in situ hybridization in detecting chromosomal abnormalities of spontaneous abortion.Methods:78 patients who suffered from spontaneous abortion were observed.All of these cases were detected chromosome 13,16,18,21,22,X and Y by FISH.Results:In 78 cases of abortion villi test results were found in 16 patients with abnormal,abnormal karyotype detection rate of 20.5%,which found triploid four cases;4 cases of trisomy 16;5 cases of trisomy 21;3 cases of trisomy 22.Conclusions:Abnormal number of chromosomes are the main factors leading to spontaneous abortion of early pregnancy,FISH technology can quickly detect chromosomal abnormalities of abortion villi.%目的 探讨荧光原位杂交(FISH)技术诊断自然流产绒毛组织染色体异常中的应用价值.方法 应用FISH技术对78例孕早期流产绒毛组织进行13/16/18/21/22/X/Y染色体检测分析.结果 78例流产绒毛FISH检测结果中,共发现16例异常,异常核型检出率20.5%,其中发现三倍体4例;16三体4例;21三体5例;22三体3例.结论 染色体数目异常是导致孕早期自然流产的主要因素,FISH技术可以快速地检测出流产绒毛组织染色体异常.

  8. Role of androgen receptor CAG repeat polymorphism and X-inactivation in the manifestation of recurrent spontaneous abortions in Indian women.

    Meka Aruna

    Full Text Available The aim of the present study was to investigate the role of CAG repeat polymorphism and X-chromosome Inactivation (XCI pattern in Recurrent Spontaneous Abortions among Indian women which has not been hitherto explored. 117 RSA cases and 224 Controls were included in the study. Cases were recruited from two different hospitals--Lakshmi Fertility Clinic, Nellore and Fernandez Maternity Hospital, Hyderabad. Controls were roughly matched for age, ethnicity and socioeconomic status. The CAG repeats of the Androgen Receptor gene were genotyped using a PCR-based assay and were analysed using the GeneMapper software to determine the CAG repeat length. XCI analysis was also carried out to assess the inactivation percentages. RSA cases had a significantly greater frequency of allele sizes in the polymorphic range above 19 repeats (p = 0.006, which is the median value of the controls, and in the biallelic mean range above 21 repeats (p = 0.002. We found no evidence of abnormal incidence of skewed X-inactivation. We conclude that longer CAG repeat lengths are associated with increased odds for RSA with statistical power estimated to be ∼90%.

  9. A SNP in pri-miR-10a is associated with recurrent spontaneous abortion in a Han-Chinese population.

    Li, Ying; Wang, Xue-Qin; Zhang, Lu; Lv, Xiao-Dan; Su, Xing; Tian, Shi; Liu, Chun-Mei; Ma, Xu; Xia, Hong-Fei

    2016-02-16

    MicroRNA-10a (miR-10a) has a wide range of functions in nearly all mammalian tissues and is involved in the occurrence of many diseases. However, it remains unknown whether miR-10a is associated with human recurrent spontaneous abortion (RSA). In this study, we found that rs3809783 A > T in miR-10a coding region was significantly associated with the increase of the risk of human unexplained RSA (URSA) acquisition in a Han-Chinese population. The T allele of rs3809783 hindered the production of mature miR-10a. A to T substitution in miR-10a rs3809783 repressed cell proliferation and migratory capacity. Further investigation discovered that Bcl-2-interacting mediator (Bim) was the functional target of miR-10a and inversely regulated Bim expression. Dual-luciferase assay indicated that A allele in miR-10a rs3809783 could more effectively suppress Bim expression than T allele. In addition, A to T substitution in miR-10a rs3809783 attenuated the sensibility of cells to progesterone and its antagonist mifepristone. Collectively, our data suggest that rs3809783 A > T in pri-miR-10a may be conductive to the genetic predisposition to RSA by disrupting the production of mature miR-10a and reinforcing the expression of Bim.

  10. Effectiveness of leukocyte immunotherapy in recurrent spontaneous abortion%复发性流产的免疫治疗效果分析

    麦明琴; 吴菁; 魏然; 黄华梅; 钟燕芳

    2009-01-01

    Objective: To evaluate the effectiveness of leukocyte immunization therapy for treatment of recurrent spontaneous abortion (RSA). Methods: 454 non-pregnant women recognized as RSA were referred for immunotherapy, all the cases were immunized by isolated lymphocytes from their husbands. Patients up to 20 weeks in gestation were recognized as successfully treatment outcome. 116 (25.55%) cases out of 454 were given birth, the totally efective rate was 70. 48% (not including gestation before 20th week), we found 1 fetal suffered with anencephaly and 1 congenital heart disease, the malformation rate was 0. 44%. Conclusion: The results showed evidence that immunotherapy is one of the effective and safe methods for RSA.%目的 了解采用淋巴细胞对复发性流产进行主动免疫的疗效.方法 采用丈夫外周血淋巴细胞治疗复发性流产,454例患者疗程结束并成功随访,妊娠至20周后者为治愈.结果 116(25.55%)例足月分娩,治愈率70.48%(未包括已孕20周内).其间1例孕20周诊断无脑儿,1例孕26周超声示胎儿先天性左心发育不良,畸形率0.44%.结论 免疫治疗是安全、有效的治疗复发性流产的方法之一,能确实解决病患实际问题.

  11. An increase in vascular endothelial growth factor (VEGF and VEGF soluble receptor-1 (sFlt-1 are associated with early recurrent spontaneous abortion.

    Lihong Pang

    Full Text Available Recurrent spontaneous abortion (RSA is a health problem that affects approximately 1% to 5% reproductive age woman. Yet, in around half of these patients, the mechanism for RSA is unexplained. Recent studies have indicated that placental ischemia/hypoxia and endothelial dysfunction are important factors in miscarriage. Other studies have indicated that the level and expression of soluble FMS-like tyrosine kinase-1 (sFlt1 is increased under a hypoxic environment. However, decreased sFlt-1 in the maternal circulation during the first trimester has recently been proposed as a potential marker for identifying risk of pregnancy loss. In this prospective study clinical samples were obtained within a short time after the fetal death, protein expression and maternal serum levels of sFlt1 were assessed and compared to samples taken from those with normal pregnancies. Our results indicate that levels of VEGF and sFlt-1 are both increased in women during early pregnancy compared women that are not pregnant (p<0.05 indicating that VEGF and sFlt-1 are both associated with pregnancy. More importantly, we detected a significant (p<0.05 increase in sFlt1 and VEGF levels and expression in the RSA patients who suffered subsequent miscarriages compare to controls. These results demonstrate that there is likely a relationship between VEGF, sFlt-1 and RSA suggesting that the high levels and over expression of sFlt-1 and VEGF might be associated with the pathogenesis of RSA.

  12. Reproductive Hazards Still Persist in the Microelectronics Industry: Increased Risk of Spontaneous Abortion and Menstrual Aberration among Female Workers in the Microelectronics Industry in South Korea

    Kim, Inah; Kim, Myoung-Hee; Lim, Sinye

    2015-01-01

    Objectives Despite the global expansion of supply chains and changes to the production process, few studies since the mid-1990s and 2000s have examined reproductive risks of the microelectronics industry; we examined the reproductive risks among female microelectronics workers in South Korea. Methods Based on claim data from the National Health Insurance (2008–2012), we estimated age-specific rates of spontaneous abortion (SAB) and menstrual aberration (MA) among women aged 20 to 39 years. We compared data between microelectronics workers and three different control groups: economically inactive women, the working population as a whole, and workers employed in the bank industry. For an effect measure, age-stratified relative risks (RRs) were estimated. Results Female workers in the microelectronics industry showed significantly higher risk for SAB and MA compared to control groups. The RRs for SAB with reference to economically inactive women, working population, and bank workers in their twenties were 1.57, 1.40, and 1.37, respectively, and the RRs for MA among females in their twenties were 1.54, 1.38, and 1.48, respectively. For women in their thirties, RRs for SAB were 1.58, 1.67, and 1.13, and those for MA were 1.25, 1.35, and 1.23 compared to the three control populations, respectively. All RRs were statistically significant at a level of 0.05, except for the SAB case comparison with bank workers in their thirties. Conclusions Despite technical innovations and health and safety measures, female workers in microelectronics industry in South Korea have high rates of SAB and MA, suggesting continued exposure to reproductive hazards. Further etiologic studies based on primary data collection and careful surveillance are required to confirm these results. PMID:25938673

  13. Reproductive Hazards Still Persist in the Microelectronics Industry: Increased Risk of Spontaneous Abortion and Menstrual Aberration among Female Workers in the Microelectronics Industry in South Korea.

    Inah Kim

    Full Text Available Despite the global expansion of supply chains and changes to the production process, few studies since the mid-1990 s and 2000s have examined reproductive risks of the microelectronics industry; we examined the reproductive risks among female microelectronics workers in South Korea.Based on claim data from the National Health Insurance (2008-2012, we estimated age-specific rates of spontaneous abortion (SAB and menstrual aberration (MA among women aged 20 to 39 years. We compared data between microelectronics workers and three different control groups: economically inactive women, the working population as a whole, and workers employed in the bank industry. For an effect measure, age-stratified relative risks (RRs were estimated.Female workers in the microelectronics industry showed significantly higher risk for SAB and MA compared to control groups. The RRs for SAB with reference to economically inactive women, working population, and bank workers in their twenties were 1.57, 1.40, and 1.37, respectively, and the RRs for MA among females in their twenties were 1.54, 1.38, and 1.48, respectively. For women in their thirties, RRs for SAB were 1.58, 1.67, and 1.13, and those for MA were 1.25, 1.35, and 1.23 compared to the three control populations, respectively. All RRs were statistically significant at a level of 0.05, except for the SAB case comparison with bank workers in their thirties.Despite technical innovations and health and safety measures, female workers in microelectronics industry in South Korea have high rates of SAB and MA, suggesting continued exposure to reproductive hazards. Further etiologic studies based on primary data collection and careful surveillance are required to confirm these results.

  14. A correlative study on Bisphenol A and recurrent spontaneous abortion%双酚A与复发性流产的相关性

    刘银梅; 沈月平; 梁红; 王燕; 罗晓明; 沈宗姬; 陈昕; 袁伟

    2011-01-01

    Objective This study was to investigate the association of Bisphenol A and unexplained conducted.Sixty patients with unexplained recurrent abortion were included.Each case was matched with one normal control by age(± 2 years),living district and the same gestational age.The levels of Bisphenol A in urine for 60 cases and 60 controls were detected using high performance liquid chromatography after fluorescent derivatization.The levels of urinary Bisphenol A in case was compared with that in control in education levels,occupation,smoking history.Data was analyzed by means of Wilcoxon-test,StudentNewman-Keuls after rank transform,univariate and multivariate conditional Logistic regression analysis.The software used was SAS 9.1.3.Results The values of urinary Bisphenol A in cases and controls were (0.10 ± 0.21)μg/ml,(0.03 ± 0.08)μg/ml,respectively.The level of urinary Bisphenol A in cases was significantly higher than that in controls(Z = 3.988,P <0.0001).The urinary Bisphenol A levels in cases were significant higher than those in controls from senior middle school(the levels were 0.10,0.06 μg/ml respectively,Z = 1.996,P = 0.0459),college(the levels were 0.14,0.03 μg/ml respectively,Z = 2.586,P = 0.0097),workers or farmers(the levels were 0.08,0.03 μg/ml respectively,Z = 2.265,P = 0.0235),businessmen(the levels were 0.10,0.03 μg/ml respectively,Z = 2.544,P = 0.0109),and no passive smokers(the levels were 0.09,0.03 μg/ml respectively,Z = 3.767,P =0.0002).After adjustment by age,body mass index,marital status during pregnancy and other factors,compared to Bisphenol A below 0.06 μg/ml,the adjusted OR was 4.03(1.67-9.74)for Bisphenol A levels between 0.06 μg/ml and 0.20 μg/ml,and was 5.46(1.95-15.27)for Bisphenol A over 0.20 μg/ml-The risk of unexplained recurrent spontaneous abortion increased progressively with the growth of urinary Bisphenol A levels(x2 =13.042,trend test P=0.0003).There were significant differences on Bisphenol A among controls

  15. Determination of antioxidant enzyme activities and lipid peroxidation in decidua tissue of women with spontaneous abortion in Guangzhou%广州地区流产妇女蜕膜组织中氧化应激指标评价

    康阳; 吴思萍; 马静; 高永清

    2012-01-01

    目的 通过检测自然流产妇女蜕膜组织中丙二醛(MDA)、过氧化氢(H2O2)的含量,以及超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)的活力,探讨氧化应激与自然流产的关系.方法 于2010年10月至2011年4月在广州3家医院收集进行流产刮宫术的孕妇蜕膜,选取正常早孕妇女为对照组.用化学比色法对蜕膜组织中MDA、H2O2、SOD、CAT、GSH-Px进行测定.结果 共收集流产刮宫术的孕妇蜕膜124例,包括62例自然流产妇女及62例正常早孕的对照组妇女.自然流产组与正常早孕组平均年龄分别为(28.63 ±6.08)、(25.16±5.41)岁,BMI分别为20.99±3.82、19.32±2.17.在自然流产组和正常早孕组中,无流产史妇女分别占41.9%、66.1%,流产1次以上的分别占24.2%、12.9%.自然流产妇女蜕膜中MDA、H2O2水平分别为(1.23±0.65)、(35.68±22.48) mmol/gprot,而正常早孕妇女分别为(0.96±0.41)、( 26.42±11.74) mmol/gprot,自然流产组均高于正常早孕组(P<0.01);自然流产妇女蜕膜中SOD活力为(18.42±7.90) U/mgpro,而正常早孕组为(21.02±6.00) U/mgpro,自然流产组低于正常早孕组(P<0.05);2组CAT、GSH-Px活力差异无统计学意义(P>0.05).MDA与H2O2、CAT呈正相关(r=0.533、0.477,均P<0.01),而与SOD呈负相关(r=-0.199,P<0.05).H2O2与CAT呈正相关(r=0.475,P<0.01),与SOD呈负相关(r=-0.324,P<0.01).结论 自然流产蜕膜组织中存在氧化应激,脂质过氧化增加和抗氧化酶活力减弱可能与自然流产的发生有关.%Objective To determine the levels of MDA, H2O2 and activity of SOD, CAT, GSH-Px in decidua of women with spontaneous abortion to investigate the possible relationship between oxidative stress and spontaneous abortion. Methods We collected decidua tissue of women with spontaneous abortion from October 2010 to April 2011 in Guangzhou. The normal pregnant women who had elective abortion were taken as the control

  16. Detección de Neospora caninum en fetos bovinos abortados espontáneamente en el nordeste argentino Neospora caninum detection in spontaneously aborted bovine fetuses from Argentine northeast

    W.J. Lertora

    2010-12-01

    Full Text Available El objetivo del presente trabajo fue detectar Neospora caninum en neonatos y fetos bovinos de abortos espontáneos del nordeste argentino. Sobre un total de 26 fetos bovinos abortados espontáneamente (23 de cría y 3 de tambo se detectaron lesiones histopatológicas compatibles con neosporosis en 4 de ellos. La presencia de Neospora caninum fue confirmada mediante inmunohistoquímica en el encéfalo de 3/4 fetos (2 de cría y 1 de tambo con lesiones microscópicas compatibles con neosporosis. Las lesiones histopatológicas más relevantes fueron la asociación de encefalitis, miocarditis y hepatitis no purulenta multifocales. De 10 neonatos bovinos procesados (8 de cría y 2 de tambo, no se detectaron animales con lesiones compatibles con neosporosis. Este trabajo confirma la presencia de Neospora caninum en fetos abortados espontáneamente en bovinos de rodeos de cría y de tambo del nordeste argentino.The aim of this work was to detect the presence of Neospora caninum in bovine neonates and bovine spontaneous abortions from Argentine northeast. Histopathological lesions compatible with neosporosis were found in 4 of 26 bovine spontaneous abortions (23 beef herds and 3 dairy herds. The Neospora caninum presence was confirmed with immunohistochemical analysis in encephalic tissue in 3 of 4 fetuses (2 beef herds and 1 dairy herd that displayed microscopical lesions of neosporosis. Multifocal non-purulent encephalitis, myocarditis and hepatitis were the most relevant lesions. There were no lesions of neosporosis in 10 bovine neonates (8 beef herds and 2 dairy herds. This work confirms the presence of Neospora caninum in spontaneous bovine abortions of beef herds and dairy herds of the Argentine northeast.

  17. 复发性流产患者免疫治疗的护理%Nursing care of patients receiving immunotherapy for recurrent spontaneous abortion

    伍洁华; 魏丽芳; 林维新; 谭雪; 萧丽新; 叶文静

    2012-01-01

    Objective To explore nursing methods for patients receiving immunotherapy for recurrent spontaneous abortion(RSA). Methods Totally, 183 patients diagnosed as RSA were given immunotherapy. Before the therapy, the blood donors were all set, and patients' mental state was kept stable. During the therapy, nurses injected lymphocytes suspension correctly and monitored the skin raise at the injection site, and strengthened care of local skin as well as health education, etc. Results Blocking antibodies were positive or weakly positive in 137 cases after one round of treatment, 46 received 2-4 rounds of treatment and 38 cases blocking antibodies turned positive. The total positive rate was 95. 62%. Of the 183 cases, 124 cases had successful conception. Conclusion Immunotherapy has a high success rate in treating RSA. Furthermore, systematic standard medical care combined with psychological care is the warranty of success.%目的 探讨复发性流产患者免疫治疗的护理方法.方法 对183例复发性流产患者予以免疫治疗,同时做好免疫治疗前供血者准备、患者准备及患者心理护理,正确注射淋巴细胞悬浊液并监测皮丘,加强注射局部皮肤的护理及健康教育等.结果 免疫治疗1个疗程后,137例封闭抗体为阳性或弱阳性,其余46例再予加强治疗2~4次,38例转为阳性,总转阳率为95.62%,其中124例妊娠成功.结论 复发性流产患者免疫治疗成功率高,进行系统、规范的医疗护理,结合心理护理是复发性流产患者免疫治疗成功的保证.

  18. Women and men’s psychological adjustment after abortion: a six months prospective pilot study

    2011-01-01

    Background: The psychological impact of abortion is a controversial issue. While some studies indicate that women who had elective abortions present lower psychological distress when compared with those who had spontaneous or therapeutic abortions, other studies found abortion to be associated with significant psychological distress. Objectives: To assess psychological adjustment (emotional disorder, trauma symptoms and couple relationship) one and six months after abortion,...

  19. APPLICATION OF HORMONE ADJUSTMENT IN TREATMENT OF RECURRENT SPONTANEOUS ABORTION%激素调整在复发性流产保胎治疗中的应用

    商微; 王蔼明; 吕立波; 张雷; 舒明明; 赵勇

    2014-01-01

    目的:通过排卵后即开始对复发性流产患者的激素水平进行调整,探讨一种安全、高效、实用的临床保胎方案。方法选取复发性流产患者172例。所有患者自然流产均发生在孕12周或孕12周之前,并均有孕酮保胎失败史。排卵后开始根据测定的激素水平给予相应的外源性雌激素、孕激素和(或)促黄体生成素进行保胎治疗并定期检测激素水平,看到胎心时开始逐渐减量,观察至孕12周,随访至出生后3个月。结果复发性流产患者孕早期保胎成功率为95.32%。结论从排卵后即开始有针对性地进行激素调整保胎治疗可以提高孕早期保胎成功率。%OcjectiVe To discuss a safe,efficient and practical clinical miscarriage plan,by adjusting the hormone levels of recurrent spontaneous abortion patients after ovulation. Methods The study enrolled 171 recurrent spontaneous abortion patients and all patients with spontaneous abortion occurred before 12 weeks or 12 weeks of pregnancy,and had a history of progesterone abortion failure. On the basis of the determined hormone levels,appropriate eXternally estrogen,progesterone and luteinizing hormone were used to prevent miscarriage after ovulation and the hormone levels were determined periodically. The dose began to reduce gradually when the fetal heart was observed until 12 weeks of pregnancy. Follow up lasted till three months after birth. Results Patients with recurrent miscarriage in early pregnancy miscarriage got the success rate 95. 32%by the treatment. Conclusion Targeted to adjustment hormone levels after ovulation can enhance the early stages of miscarriages success rate.

  20. Analysis the Result of 105 Cases Spontaneously Abortion Detecting by MLPA%应用MLPA检测105例自然流产绒毛的结果分析

    黄朋; 费冬梅; 刘天盛; 黄红倩; 郑陈光

    2013-01-01

    目的:应用多重探针扩增技术(multiplex ligation-dependent probe ampli-cation,MLPA)检测自然流产与21、18、13及性染色体数目异常的关系。方法对105例自然流产胎儿绒毛组织进行MLPA检测,PCR产物用3130基因分析仪进行信号收集,应用Cof alyzer对电泳结果进行片段分析。结果105例标本中有101例检测成功(97.1%),提示有43例为染色体核型异常,其中24例45,X,4例47,+21,2例47,+18,9例47,XXY,4例47,+13,总的异常检出率为42.6%。结论对101例流产标本的检测与分析,有42.6%的因素是由于21、18、13及性染色体异常引起的,其中性染色体异常占所有异常核型的76.7%,说明性染色体异常是流产的易感因子。%Objective: To analysis the relationship of spontaneously abortion and 21, 18, 13 and sex chromosome aneuploidy abnormality with the technology of multiple ligation-dependent probe amplification(MLPA). Methods:105 spontaneously abortion chorionic vil us was detected by MLPA using kit P095 and the results were obtained by using ABI3130 genetic analyzer; Analysis of copy number changes for chromosomes 13, 18, 21, X and Y was carried out with Cof alyzer. Results: MLPA test was successful in 101 cases (97.1%), indicated 48 cases were chromosome aneuploidy abnormal, including 24 cases 45X, 4 cases +21, 9 cases XXY, 4 cases +13; the abnormal rate was 42.6%. Conclusion:about 42.6%spontaneously aborted was caused by aneuploidy abnormal (13, 18, 21, X and Y), about 76.7% was sex chromosome abnormal, this indicated sex chromosome abnormal was an importance factor induced abortion.

  1. 基因多态性与复发性自然流产的相关性研究%Study on the relationship between gene polymorphism and repeated spontaneous abortion

    李静益; 傅萍

    2012-01-01

    Repeated spontaneous abortion ( RSA) refers to abortions that occurred in succession two or more than two. The causes of RSA are complicated, including chromosomal abnormality of embryos, abnormal immune functions, luteal insufficiency, infection, genitourinary tract anomaly and so on. But now there are still some etiology and pathogenesis of RSA which are not clear, changes in genetic background and other facters may cause part of populations prone to RSA. Rerrent years some new points are put forward from the perspective of Immunology and Genetics, considering the causes of RSA are related with hereditary. Trying to find out susceptibility gene or pathogenic gene and clarifying the pathogenesis of RSA fundamentally, is important to the RSA treatment and prevention.%复发性自然流产(recurrent spontaneous abortions,RSA)是指连续发生2次或2次以上流产者.RSA的病因复杂,包括胚胎染色体异常、免疫功能异常、黄体功能不足、感染、生殖道异常等.但目前仍有部分RSA患者病因及发病机制尚不清楚,遗传背景等因素的改变可能使部分人群易发生RSA[1].近年来从免疫遗传角度提出了一些新的观点,认为RSA的发生与遗传有关.寻找RSA的易感基因或致病基因,从根本上阐明RSA的发病机理,是RSA治疗和预防的重要途径.

  2. Association between electromagnetic radiation exposure and spontaneous abortion and influencing factors%自然流产与电磁辐射暴露关系及影响因素研究

    曲英莉; 王强; 刘欣燕; 王俊; 张淑珍; 曹兆进

    2013-01-01

    目的 探讨导致早期自然流产的危险因素,研究电磁辐射暴露与早期自然流产的关系.方法 采用非配对病例对照研究,对120名临床确诊为自然流产且孕周≤12周的孕妇(病例组)及363名妊娠12周经临床确诊为正常妊娠的孕妇(对照组)就家居环境及电磁辐射暴露情况进行问卷调查.抽取有代表性的家庭进行室内、室外家居环境及家用电器的电磁场检测.结果 单因素分析中,病例组看电视时间>15h/周、使用电脑时间>10 h/周、电磁炉、手机使用时间>20 min/d、居住地周围有电磁辐射设备的比例高于对照组(P<0.05);而在多因素分析中,使用电脑时间>10h/周、使用电磁炉、手机时间>20 min/d、年龄>30岁、有不良孕产史及被动吸烟是自然流产的危险性因素.结论 妊娠期经常使用电脑、手机、电磁炉可能与早期自然流产的发生有关联.%Objective To investigate the association between electromagnetic radiation and spontaneous abortion and to identify the risk factors of spontaneous abortion.Methods A case-control study was conducted.The cases (n=120) were the pregnant women of no more than 12 weeks with spontaneous abortion,recruited at the Peking Union Medical College Hospital.The controls (n=363) were the pregnant women with normal pregnancy of 12 weeks.The house environmental electromagnetic radiation exposure was matured.Results The proportion of watching TV>15 h per week,operating computer>10 h per week,using the mobile phones>20 min per day,induction cooker and electromagnetic equipment near the dwell in the cases were significantly higher than those in the controls in single factor analysis (P<0.05); In multifactors Logistic regression analysis,operating computer >10 h per week,using the mobile phones>20 min per day,using induction cooker frequently,abnormal pregnanc history,passive smoking during pregnancy and over 30 years old were associated with

  3. A study on relationship be tween genital chlamydia trachomatis and ureaplasma urealyticum infection and spontaneous abortion%生殖道沙眼衣原体和解脲支原体感染与自然流产的相关性研究

    周萍

    2015-01-01

    目的:探讨生殖道沙眼衣原体和解脲支原体感染与自然流产的关系。方法选取我院自然流产患者(自然流产组)及人工流产患者(对照组),各60例。两组均采集宫颈分泌物及蜕膜组织进行沙眼衣原体和解脲支原体培养,分析结果。结果自然流产组宫颈分泌物及蜕膜组织中沙眼衣原体、解脲支原体、沙眼衣原体+解脲支原体感染率均高于对照组( P<0.01)。结论生殖道沙眼衣原体和解脲支原体感染率与自然流产关系密切,可作为确定自然流产病因的指标。%Objective To explore the corelation of genital chlamydia trachomatis and ureaplasma urealyticum infection with spontaneous abortion,and provide clinical reference for the prevention and control of spontaneous abortion .Methods Patients with spontaneous abortion were selected as spontaneous abortion group ( n =60) and artificial abortion group ( n =60), and cervical se-cretions and decidual tissue of chlamydia trachomatis and ureaplasma urealyticum were cultured and the results were analyzed .Results Infection rate of chlamydia trachomatis in cervical secretion of the natural abortion group ,ureaplasma urealyticum,chlamydia trachom-atis infection +UU rates of the natural abortion group were higher than that of the control group ( P <0.01).Conclusion Infection rate of genital chlamydia trachomatis and ureaplasma urealyticum infection rate and spontaneous abortion have a close relationship , which may be one of the causes of spontaneous abortion .

  4. Induced Abortion

    ... I need to follow up with my health care provider after having a medical abortion? You will need to see your health ... This is more likely to happen with a medical abortion. Infection—Your health care provider will prescribe antibiotics to prevent this. Antibiotics also ...

  5. Provokeret abort

    Christiansen, Connie; Schmidt, Garbi; Christoffersen, Mogens

    Gennem en række interview om kvinders oplevelse og erfaringer med provokert abort, samt ved at bruge data fra en stor forløbsundersøgelse af kvinder født i 1966, giver forfatterne bag denne rapport et præcist signalement af de kvinder, der vælger at få foretaget en provokeret abort og de eventuelle...... for sundhedspersonale og andre socialarbejdere. Den statistiske undersøgelse viser, at hver fjerde danske kvinde vil komme i den situation at skulle have en abort. Især kvinder med vanskelige opvækstvilkår er i risikogruppen. Tilgengæld er der næsten ingen langvarige fysiske og psykiske virkninger abort af abort, med...

  6. 荧光原位杂交技术检测自然流产组织染色体非整倍体%Detection of chromosomal aneuploidies in spontaneous abortion samples by fluorescence in situ hybridization

    魏萍; 李运星; 陈春; 曾兰; 秦胜芳; 汪雪雁; 席娜

    2015-01-01

    目的 探讨荧光原位杂交(fluorescence in situ hybridization,FISH)技术在自然流产组织染色体非整倍体检测中的价值和自然流产患者中染色体非整倍体比例.方法 对81份自然流产组织标本进行13、21和16、22及18、X、Y三组染色体探针的FISH检测.结果 81份自然流产组织中成功标记80份,检测成功率98.77%,其中异常标本35例,异常检出率43.75%,分别为常染色体三体19例,性染色体单体6例,三倍体9例,四倍体1例.结论 FISH技术用于自然流产组织染色体非整倍体分析具有快速、简便等优点,FISH分析可满足染色体非整倍体分析的需要;早期的自然流产病例中染色体非整倍体占较大的比例.%Objective To analyze 81 spontaneous abortion samples with fluorescence in situ hybridization (FISH).Methods Chromosome 13,21,16,22,18,X and Y probes were used to detect the samples.Results FISH was successful in 80 cases (98.77%).Among these,35 (43.75%) had an abnormal karyotype,which included 19 autosomal aneuploidies,6 sex chromosome aneuploidies,9 triploidies and 1 tetraploidy.Conclusion FISH is a rapid and easy method for detecting chromosomal aneuploidies in spontaneous abortion samples,and has a higher detection rate in early spontaneous abortion samples.

  7. Detection of Numerical Chromosomal Anomalies in Spontaneous Abortion by Fluorescent in situ Hybridization%FISH技术在检测自然流产绒毛组织非整倍体异常中的应用研究

    周佳; 蔡彩萍; 姚红霞; 骆敏; 郭茗; 杨颖俊; 孙路明

    2013-01-01

    Objective:To study the clinical value of fluorescent in situ hybridization (FISH) detection method for numerical chromosomal anomalies in spontaneous abortion and to evaluate its efficiency compared with the classic method of karyotyping.Methods:A total of 157 patients who suffered from spontaneous abortion were observed.All of these cases were detected chromosome 16,22,13,21,18,X and Y by FISH.The chorionic villi samples (CVS) were cultured for chromosome analysis at the same time.Results:Seventy-six samples were successfully karyotyped,while the success rate of FISH was 100%.For the two methods,64 cases matched perfectly,and the corresponding rate of FISH to karyotyping was 84.2%.Conclusion:FISH provides a diagnosis for spontaneous abortion because of rapid,easy to carry out and higher successful rate.Although FISH can not substitute the traditional karyotping,it can be a supplementary method to traditional kayotyping.%目的:探讨运用荧光原位杂交(FISH)检测自然流产绒毛组织的临床价值,评价它与传统经典的核型分析方法的关系.方法:对157例孕早期自然流产的绒毛组织进行FISH检测,均采用16、22、13、21、18、X、Y号染色体荧光探针检测,判断染色体非整倍体异常情况.同时进行绒毛细胞培养染色体核型分析,作为对照诊断标准.结果:核型分析成功率为48.4%,FISH检测成功率为100%.核型分析成功的76例样本中,64例结果与核型分析结果相一致,以细胞遗传学作为诊断标准,诊断的符合率为84.2%.结论:FISH技术与传统的绒毛细胞培养染色体核型分析相比,过程迅速,方法简单,提高了诊断的成功率,但无法完全取代传统的染色体核型分析,应两者结合应用于临床.

  8. Application of gene array chip in diagnosis of cytogenetics of recurrent spontaneous abortion%基因芯片技术在复发性流产遗传学诊断中的应用

    沈国松; 张甦; 何平亚

    2013-01-01

    目的 探讨基因芯片单核苷酸多态性阵列(SNP-array)技术在复发性流产遗传学诊断中的应用价值.方法 选择2012年1-10月在浙江省湖州市妇幼保健院产前诊断中心就诊的、曾有自然流产≥2次、本次妊娠又发生自然流产的患者26例(RSA组),对流产物分别应用绒毛染色体核型分析技术和SNP-array技术进行分析;同时选取20例早孕期人工流产妇女作为对照组.结果 绒毛染色体核型分析获得结果19例,检测成功率为73% (19/26),发现染色体异常10例,异常检出率为10/19;SNP-array技术检测获得结果26例,检测成功率为100%,发现全基因组拷贝数异常15例,异常检出率为58% (15/26).对照组胚胎绒毛染色体核型分析获得结果16例,检测成功率为16/20,均未发现染色体核型异常;SNP-array技术检测获得结果20例,检测成功率为20/20,均未发现全基因组拷贝数异常.结论 SNP-array技术具有分辨率高、准确性好等优点,是自然流产特别是复发性流产遗传学诊断的有力工具.%Objective To investigate clinical value of single nucleotide polymorphism array (SNParray) gene chip technique in diagnosis of genetics of recurrent spontaneous abortion (RSA).Methods From January to October 2012,the 26 patients with more than twice of spontaneous abortion in Huzhou Maternal and Child Health Care Hospital were enrolled in this study(RSA group).Meanwhile 20 cases with induced abortion were taken as control group.All aborted tissues were analyzed with conventional cytogenetic karyotyping and SNP-array,respectively.Results Chorionic villus chromosomal examination was successfully done in 19 cases (73%,19/26),which 10 cases were found with chromosomal anomaly,the overall detection rate is 10/19.However,SNP-array analysis was successfully performed in all 26 cases.The overall rate of detection was 100%,and abnormalities were found in 15 cases,which reached the detection rate was 58% (15

  9. 黄体酮个体化治疗复发性流产的临床研究%Clinical research for the individualized treatment of recurrent spontaneous abortion by progesterone

    刘晓菲

    2015-01-01

    Objective To investigate the clinical effect of the individualized treatment of recurrent spontaneous abortion by progesterone. Methods The clinical data of 60 cases of patients with recurrent spontaneous abortion were retrospectively analyzed, and according to the treatment methods, divided into the experimental group and control group, 30 cases in each group. The control group was given conventional dose progesterone injection. According to the weekly inspection progesterone, patients in the experimental group were adjusted the dosage of progesterone. The pregnancy of 12 weeks, the number of days of injection dosage of progesterone and the mean gestational age at delivery, abortion, premature delivery, perinatal adverse outcomes (death and disease incidence rate) between two groups were compared. Results The total amount progesterone of the test group (1456.23±206.36)mg, and (36.23±6.54) days of the injection of days significantly less than the control group (1827.48±242.05) mg,(43.54±3.63)d. The differences between the two groups were statistically significant (P < 0.05). The average gestational age at delivery, abortion, premature delivery rate and adverse perinatal outcome (mortality and morbidity) incidence of experimental group was less than that of the control group, the difference was statistically significant (P < 0.05). Conclusion Progesterone personalized dose adjustment can improve the success rate of patients with recurrent spontaneous abortion, and reduce the dosage and the adverse perinatal outcome. It is more suitable for clinical application.%目的:探讨黄体酮个体化治疗复发性流产的临床疗效。方法回顾性分析本院就诊的60例复发性流产患者的临床资料,根据治疗方法将其分为试验组与对照组,每组各30例,对照组每日常规剂量肌肉注射黄体酮,试验组患者根据每周检查孕酮值调整黄体酮用量。比较分析两组患者治疗至孕12周黄体酮用量、注射

  10. The related factors analysis of pregnancy outcome for recurrent sponta-neous abortion%复发性流产妊娠结局的相关因素分析

    胡青萍; 戚潜辉

    2015-01-01

    Objective To study the related factors of pregnancy outcome For recurrent spontaneous abortion (RSA). Methods Clinical data of 120 cases with RSA pregnancy treated in our station and the Second Affiliated Hospital of Guangzhou Medical College from March 2012 to February 2014 were retrospectively analyzed.Related factors of preg-nancy outcome for RSA were statistically analyzed. Results 27 cases with pregnancy failure in 120 patients with RSA and the failure rate was 22.50%.Age,gestational age when seeing a doctor,HOMA-IR ,nursing one’s health before preg-nancy,the number of abortion >3 times,endocrine abnormality,positive antisperm antibody and positive anticardiolipin antibody and so on had significant impact on pregnancy outcome (P3次、内分泌异常、抗精子抗体阳性、抗心磷脂抗体阳性等对妊娠结局有重要影响(P<0.05);年龄、就诊时孕周、抗心磷脂抗体阳性为妊娠结局失败的独立危险因素(P<0.05)。结论控制RSA妊娠结局的相关因素,尤其是妊娠结局失败的独立危险因素,可有效降低妊娠结局的失败率。

  11. Measurement of plasma human chorionic gonadotropin (hCG) and beta-hCG activities in the late luteal phase: evidence of the occurrence of spontaneous menstrual abortions in infertile women.

    Chartier, M; Roger, M; Barrat, J; Michelon, B

    1979-02-01

    Plasma luteinizing hormone (LH-human chorionic gonadotropin (hCG) and beta-hCG activities were measured during the late luteal phase in 321 cycles of 147 infertile women. In 71 cycles the hCG measurement permitted the diagnosis of pregnancy between the 10th and 14th days after the thermal nadir. The slope of the regression line derived from hCG levels during the first 22 days of pregnancy was significantly lower in pregnancies which aborted before the 60th day than in normal pregnancies (P less than 0.01). Among 72 cycles ended by apparently normal menses which exhibited an LH-hCG activity at least equal to 7 mIU of hCG/ml during the late luteal phase, the beta-hCG activity was measured in 49 cycles during which hCG had not been given. Significant beta-hCG activity (greater than or equal to 4 mIU of hCG/ml) was detected in 19 cases. This finding supports the assumption that secretory trophoblastic tissue had been present and that spontaneous menstrual abortions had occurred in these women.

  12. Expression of CD147 in villous tissues of patients with unexplained spon-taneous abortion%CD147在不明原因自然流产患者绒毛组织的表达∗

    唐传玲; 滕晓明; 车映; 李大金

    2016-01-01

    目的::分析CD147在不明原因自然流产患者绒毛组织中的表达水平,并探讨其生物学功能。方法:收集人早孕期正常和不明原因自然流产妇女的绒毛组织,采用免疫组织化学、RT-PCR 和Western blotting法检测CD147的表达,比较CD147在正常早孕与不明原因自然流产妇女绒毛组织的表达差异。体外分离纯化获得正常人早孕期滋养细胞,采用免疫细胞化学验证CD147在滋养细胞的表达,引入抗CD147中和性抗体处理人滋养细胞,采用BrdU增殖实验和Transwell侵袭实验分析滋养细胞增殖和侵袭能力的变化。结果:正常早孕期绒毛组织和滋养细胞高表达CD147,不明原因自然流产绒毛组织CD147的mRNA和蛋白表达水平均低于正常早孕期绒毛组织。抗CD147中和性抗体处理原代人滋养细胞后,滋养细胞的增殖能力未发生明显变化,侵袭能力下降。结论:人绒毛组织CD147的异常低表达可能与不明原因早期妊娠失败相关,CD147通过调控滋养细胞的侵袭能力参与正常妊娠的维持。%AIM: To analyze the expression levels of CD147 in villous tissues of patients with unexplained spontaneous abortion and to investigate its biological function in human primary trophoblasts in vitro. METHODS:The vil-lous tissues were collected from the women with normal early pregnancy and unexplained spontaneous abortion. The expres-sion levels of CD147 were determined by immunohistochemical staining, reverse transcriptase-polymerase chain reaction ( RT-PCR) and Western blotting. The primary trophoblasts were prepared by the trypsin-DNase I digestion and cultured in vitro. CD147 expression in the primary trophoblasts was detected by immunocytochemical staining. The primary tropho-blasts were treated with anti-human CD147 neutralizing antibody, and then the cell proliferation and invasion abilities were evaluated by BrdU incorporation assay and Matrigel-coated Transwell assay, respectively

  13. 主动免疫治疗加用地屈孕酮治疗复发性流产的临床观察%Clinical Observation on Curative Effect of Active Immunotherapy Combined with Dydrogesterone on Recurrent Spontaneous Abortion

    张娟; 方小玲; 贺艳坤; 谭小军; 黄向红

    2012-01-01

    Objective To explore the clinical efficacy of lymphocytes active immunotherapy combined with dydrogesterone on treating recurrent spontaneous abortion. Methods Seventy patients with recurrent spontaneous abortion were randomly divided into two groups (each n= 35). The patients in observation group were given active immunotherapy combined with dydrogesterone, while the patients in control group received dydrogesterone. Serum E2, P, and HCG levels of the patients of two groups were detected to evaluate the treatment outcomes. The pregnancy results were recorded and then analyzed statistically. Results There was no statistically significant difference in age, pregnancies, parity, and spontaneous abortion time between the two groups (P >0.05). And no statistically significant difference was found in serum E2, P, and HCG levels before 8 weeks or between 8 to 12 weeks (P>0.05). Among 35 patients of observation group, 34 (97.1%) succeeded in giving full - term birth. Among 35 patients of control group, 27 (77.1 % ) succeeded in giving full - term birth. There were statistically significant differences between the two groups (P<0.05). Conclusions Lymphocytes active immunotherapy combined with dydrogesterone can significantly improve the ongoing pregnancy rate in patients with recurrent spontaneous abortion.%目的 探讨淋巴细胞主动免疫治疗加用地屈孕酮治疗复发性流产的临床疗效观察.方法 2008年3月-2011年3年将70例有复发性流产患者被随机分为两组,35名要求接受淋巴细胞主动免疫治疗和地屈孕酮的患者为观察组,35名接受地屈孕酮的患者为对照组;检测两组患者血清E2、P和HCG水平,以评估治疗结果,记录妊娠结果进行统计学分析.结果 两组在年龄、孕次、产次、前次自然流产时间方面差异无统计学意义(P>0.05);两组在血清E2、P和HCG的水平在8周前及8~12周差异均无统计学意义(P>0.05).妊娠情况:淋巴细胞主

  14. Karyotype analysis on 279 couples with recurrent spontaneous abortion in Xinjiang%新疆地区279对反复自然流产夫妇的染色体核型分析

    张彩荣; 郭敏; 王文玲

    2015-01-01

    目的 探讨反复自然流产与染色体异常的关系.方法 抽取279对反复自然流产夫妇的外周血进行淋巴细胞培养,运用染色体G显带技术进行核型分析,对每例患者的标本显微镜下计数30个核型,并镜下分析其中的5个核型,异常者加倍计数分析.结果 279对反复自然流产夫妇中,检出染色体异常核型151例,异常检出率为27.1%,其中常染色体结构异常1 8例,占异常核型12%,包括易位11例,倒位5例,染色体增加片段1例,染色体缺失片段1例;染色体多态性变异133例,占异常核型88.1%,包括Y染色体多态性变异1 08例,占71.5%,其他染色体多态性变异25例,占16.6%.结论 Y染色体多态性变异是导致反复自然流产的重要遗传因素,染色体平衡易位、倒位、多态与反复自然流产有一定的关联,应进一步去探讨其内在的相互关系,为遗传咨询,优生优育提供更加可靠的依据.%Objective To analyze the correlation of abnormal karyotypes with recurrent spontaneous abortion.Methods The chromosomal karyotypes were examined in 279 couples with spontaneous abortion history by using peripheral blood lymphocyte culture and G banding.Results 151 cases of 279 couples were abnormal in karyotype,with an abnormal rate of 27.1%.Among them,there were 12% chromosome structural aberrations (18/151) including 11 translocations,five inversions,one insertion and one deletion and 88.1% chromosome polymorphism (133/151) consisting of 108 Y chromosome and 25 other chromosome variations.Conclusion Y chromosome polymorphism is a significant genetic factor resulting in recurrent spontaneous abortion.Additionally,the balanced translocation,inversion and polymorphism also have correlations with spontaneous abortion.Their correlations should be further studied to provide reliable data for genetic counseling and eugenics.

  15. 生殖道沙眼衣原体和解脲支原体感染与自然流产的临床探讨%Clinical exploration on reproductive tract infection of chlamydia trachomatis and ureaplasma urealyticum and spontaneous abortion

    程梦婕; 丁玎

    2011-01-01

    Objective: To explore the correlation between chlamydia trachomatis (CT), ureaplasma urealyticum (UU) and spontaneous abortion. Methods: lmmunochromatography and isolation culture method were used to detect CT and UU in cervical secretions of 95 cases with spontaneous abortion (observation group) and 102 cases with artificial abortion (control group) . Results: The total detection rates of CT and UU in observation group and control group were 64. 21% and 24. 51%, respectively, there was significant difference between the two groups ( P < 0. 05 ); there was no significant difference in the rate of mixed infection of CT and UU between observation group and control group ( P > 0. 05 ); there was significant difference in detection rates of CT and UU between the cases with time of spontaneous abortion≥2 and the cases with spontaneous abortion once (P<0. 05) . Conclusion: The infection of CT and UU may be related to the occurrence of spontaneous abortion, especially the occurrence of recurrent spontaneous abortion; detection of CT and UU and active treatment play important roles in prevention of adverse pregnancy outcomes for cases with spontaneous abortion.%目的:探讨沙眼衣原体(CT)、解脲支原体(UU)与自然流产的相关性.方法:采用免疫层析法和分离培养法对95例自然流产者(观察组)和102例人工流产患者(对照组)的宫颈分泌物进行CT、UU的检测.结果:①观察组宫颈分泌物CT和/或UU的总检出率为64.21%,对照组为24.51%,两组比较差异有统计学意义(P0.05).②自然流产次数≥2次者,CT、UU检出率与只有1次自然流产史者相比,差异有统计学意义(P0.05).结论:CT、UU感染与自然流产的发生可能相关,尤其与复发性自然流产关系密切,对自然流产患者进行CT和UU的检测并积极治疗对防止不良妊娠结局再次发生有重要意义.

  16. 反复自然流产与抗活化的蛋白C的研究%Study of recurrent spontaneous abortion and activated protein C-resistance

    周志中; 吴竞生; 凌斌; 李向培; 徐修才; 历小梅; 易桂英; 陈育华; 汪国生; 张雪芬

    2001-01-01

    Objective To understand the occurrence of activated protein C-resistance(APCR)in patients with recurrent spontaneous abortion(RSA)and investigate the occuring mechanism of APCR inducing the mini-thrombosis of placental vessels which results in RSA.Methods APC-KPTT assay,ELISA and PTT-LA methods were used respectively to detect APCR,anticardiolipin antibodies(ACA)and lupus anticoagulant(LA) in 32 patients with RSA and 20 normal controls(NC).Results There were 17 positive of APA(antiphospholipid antibodies) in patients.The incidence (53.1%) was significantly higher than that of NC group(0/20)(P<0.005),the incidence of LA in RSA(28.1%) was higher than that in NC group(0/20)(P<0.01),but there was no significant difference of ACA between the two groups (P>0.05).The incidence of APCR in RSA(37.5%) was significantly higher than that of NC group(5.0%)(P<0.001),but the APC-SR was lower than NC group(P<0.05).Relativity analysis indicated that the incidence of APCR in LA-positive group(66.7%) was obviously higher than that in LA-negative(26.1%)(P<0.05),but there was no significant difference between the ACA-positive and the ACA-negative(P>0.05).Conclusion There is a little bit higher incidence of APCR in patients with RSA and it is related to LA,which suggests that APCR seems to be one of the main reasons to induce the thrombosis in placental vessels which results in RSA.%目的了解抗活化的蛋白C(APCR)在反复自然流产(RSA)患者中的发生情况,并进一步探讨APCR引起胎盘血管微小血栓形成并进而引起RSA的发生机制。方法采用APC-KPTT法,ELISA法和PTT-LA法分别对32例RSA及20例正常对照(NC)进行APCR、抗心磷脂抗体(ACA)和狼疮抗凝物(LA)检测。结果 32例RSA患者共17例抗磷脂抗体(APA)阳性,其中9例LA阳性,12例ACA阳性(4例LA、ACA同时阳性),阳性率(53.1%)明显高于NC组(0/20)(P<0.005);其中LA阳性率为28.1%,明显高于NC组(P<0.01),患者ACA-IgG(0

  17. 3376例复发性流产夫妻染色体核型分析%Karyotype Analysis of 3 376 Cases of Recurrent Spontaneous Abortion Couples

    马京梅; 潘虹; 张慧婧; 付杰; 于丽; 齐雯; 杨慧霞

    2015-01-01

    目的:分析复发性流产( RSA)夫妻外周血染色体变异发生种类及其在男女性中的分布特点,为指导临床咨询及后续生殖干预提供依据。方法选取2007年9月—2014年8月在北京大学第一医院妇产科门诊主因RSA就诊的夫妻3376例,进行外周血染色体核型分析,比较染色体变异的发生率、种类、在男女性中的比例差异。结果 3376例RSA夫妻中发现染色体变异146例(4.32%),其中男85例,女61例,除去染色体多态性改变〔包括Y染色体变异(29例)、染色体次缢痕增加(28例)、D/G组染色体随体区变异(25例)及9号臂间倒位(21例)〕后,染色体异常共43例,其中相互易位最多见,为27例(62.79%),其次为罗氏易位5例(11.63%),倒位5例(11.63%),女性性染色体嵌合3例(6.98%),性反转综合征2例(4.65%),男性 Marker 染色体嵌合 1例(2.32%)。染色体多态性方面,男性以Y染色体变异最为多见(34.12%,29/85)。结论 RSA夫妻外周血染色体异常均有发生,染色体异常以相互易位为主,对以 RSA 原因就诊的夫妻,有必要同时对夫妻双方进行外周血染色体检查。%Objective To analyse the types and distribution characteristics of peripheral blood chromosomal variation among couples with recurrent spontaneous abortion ( RSA ), to provides guidance for clinical counseling and subsequent reproductive intervention. Methods A total of 3 376 cases of RSA couples who came to obstetrics and gynecology clinic of the First Hospital of Peking University from September 2007 to August 2014,were selected as study subjects,peripheral blood karyotype analysis was performed,the incidence,type and sex distribution were analyzed. Results Among 3 376 RSA cases, there were 146 cases with chromosomal variation ( 4. 32%)( 85 males and 61 females ) . After exclusion of chromosomal polymorphism〔(29 cases of Y chromosomal variation

  18. Aborto espontâneo e provocado: sentimentos vivenciados pelos homens Aborto espontáneo y inducido: sentimientos vivenciados por hombres Spontaneous and induced abortion: feelings experienced by men

    Márcia Melo Laet Rodrigues

    2006-02-01

    . The narrative analysis was the research method. The narratives of seventeen men were analysed. The spontaneous abortion related feelings were the loss related anguish and, the provoked abortion, the culpability related feelings and its consequences. Men who share the abortion experience with their partners require sensibility and professionals involvement. Their main care demands were related to the desire of favorable reception, to get emotional support as well as a whole and correct information about the process.

  19. 左甲状腺素干预后的甲状腺功能减退症对自然流产的影响%The influence of hypothyroidism on spontaneous abortion after treated with Ievothyroxine

    任美蓉; 张延丽

    2014-01-01

    Objective To study the effect of hypothyroidism be treated with levothyroxine on spontaneous abortion. Method In 30 rats suffered from hypothyroidism treated with levothyroxine,observe their pregnancy outcomes. With Methods Enzyme-linked immunosorbent assay (ELISA) was adopted to measure rats serum FT4、TSH、TPO-Ab levels,doing the vaginal smears,finding their estrous cycle, observe their pregnancy outcomes. Giving the rats which suffered from hypothyroidism levothyroxine therapy, observe their pregnancy outcomes,and with Methods ELISA was adopted to measure rats serum FT4、TSH、TPO-Ab levels. Results To compare the hypothyroidism abortion group and the hypothyroidism abortion be treated group,FT4 levels are lower,TSH levels are higher,TPO-Ab levels are higher, there were significant differences between two groups in these three assays (P0. 05);To compare offspring numbers of the hypothyroidism abortion be treated group and the normal control group,there was no significant difference in these three assays (P>0.05).Conclusion Hypothyroidism is one of the factors causing spontaneous abortion,can improve the pregnancy outcomes by levothyroxine treatment.%目的:探讨经过干预的甲状腺功能减退症对自然流产的影响。方法对30只患有甲状腺功能减退症的大鼠进行左甲状腺素干预,合笼后观察其妊娠结局。用酶联免疫吸附实验(ELISA法)测定大鼠血清中游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPO-Ab)水平,进行阴道涂片,观察其动情周期,合笼后观察其妊娠结局。结果甲减组与甲减治疗组相比FT4水平较低,TSH偏高,TPO-Ab偏高,均有显著性差异(P0.05);甲减治疗组与正常对照组仔鼠数量相比无显著性差异(P>0.05)。结论甲状腺功能减退症是导致自然流产的因素之一,可通过左甲状腺素治疗改善妊娠结局。

  20. 藏族农村育龄妇女自然流产的流行病学特征及其影响因素分析%Epidemiological features and risk factors of spontaneous abortion among rural Tibetan women at childbearing age

    范小静; 王维华; 刘如如; 党少农; 康轶君

    2014-01-01

    目的 了解藏族农村育龄妇女自然流产状况及其相关影响因素.方法 对2006-2012年藏族农村孕妇采取入户访问获得其生育史,并进行随访直至获得本次妊娠结局.采用广义Poisson回归模型探索影响自然流产的因素,估计各研究因素的OR值及其95%CI.结果 共随访1 557名孕妇,总妊娠2 687次,总产次2 382次,发生自然流产171人204次;人工流产93人101次.自然流产妊娠比为7.6%,自然流产率为7.9%,发生自然流产的育龄妇女比例为11.0%.孕次是发生自然流产的重要原因,随着孕次增加,育龄妇女发生自然流产的风险增加,孕次超过3次时其风险最大,Poisson回归分析OR=3.921 (95% CI:2.553 ~ 6.021),aOR=4.722(95%CI:2.834~7.866);随着产次的增加,育龄妇女发生自然流产的风险减少.自然流产的发生风险与怀孕年份有关,2009年后妇女发生自然流产的风险较低,OR=0.419(95%CI:0.285~ 0.616),aOR=0.580(95%CI:0.380 ~ 0.885).并未发现社会人口学特征与其自然流产的发生有显著关联.结论 藏族育龄妇女自然流产率并不高于陕西等平原地区,加强孕产期保健、延长生育间隔和减少育龄妇女的妊娠次数有助于降低西藏地区育龄妇女发生自然流产的风险.%Objective To study the current status and risk factors of spontaneous abortion of women with Tibetan ethnicity at reproductive age in rural areas.Methods Pregnant women who lived in fibet were interviewed on their former reproductive history and being followed on the outcomes of pregnant from 2006 to 2012.Generalized Poisson regression model was used to explore the influencing factors of spontaneous abortion.OR value of the research factors was estimated and its 95% confidence interval counted.Results There were 1 557 pregnant women under this study,with a total number of 2 687 pregnancies and 2 382 productions.171 women underwent spontaneous abortion,with a total number of 204 times,93

  1. 浅析王秀霞教授治疗复发性流产的辨证及遣方用药特点%A clinical analysis of Professor Wang Xiuxia for treating recurrent spontaneous abortion by differential treatment

    韩凤娟; 付杨; 王秀霞

    2016-01-01

    浅析王秀霞教授治疗复发性流产的中医辨证思想以及其遣方用药的特色。王老认为肾虚是导致复发性流产的主要原因,因此在治疗上多以补肾助阳之药为主,提倡对于反复流产的患者应在孕前即开始对症治疗;患者再次妊娠后也应积极保胎,直至无胎漏、胎动不安征象的出现。%TCM syndrome differentiation thought and medication characteristics of Professor Wang Xiuxia for treating recurrent spontaneous abortion were analyzed. Doctor Wang thought that kidney deficiency was the main reason of recurrent spontaneous miscarriage, so kidney-tonifying medicines were applied mainly in clinic; symptomatic treatment should be applied before pregnancy; after pregnant, preventing from miscarriage should be paid more attention in order to ensure the safety of the fetus.

  2. A meta-analysis of spontaneous abortion associated with ureaplasma urealyticum infection of reproductive tract in women%妇女生殖道解脲支原体感染与自然流产关联的 meta 分析

    裴丽君; 王亚菲; 郭超; 朱琳; 江素真; 郑晓瑛

    2012-01-01

    目的:探讨妇女生殖道解脲支原体感染与自然流产、稽留流产发生关联.方法:检索自然流产和稽留流产文献数据并进行整理,用Mantel-Haenszel法合并OR值,并进行meta分析.结果:妇女孕早期生殖道解脲支原体感染发生自然流产的合并OR值为4.72(95%CI:3.77 ~5.92),发生稽留流产的合并OR值为4.31(95%CI:2.68 ~6.94);在有解脲支原体感染史妇女中,自然流产和稽留流产的发生危险随着其复发次数的增加而升高.结论:妇女生殖道解脲支原体感染是自然流产和稽留流产发生的可能危险因素,有效诊断解脲支原体感染,可避免妇女生殖道感染中滥用或误用抗生素问题.%Objective: To evaluate the associations between the risk of missed abortion and spontaneous abortion and ureaplasma urealyticum (UU) of reproductive tract infections among Chinese women. Methods: Multiple databases were searched and odd ratio (OR) was pooled using Mantel - Haenszel method. A meta - regression analysis was performed using restricted maximum likelihood. Results: The risks of spontaneous abortion and missed abortion were associated with intrauterine UU infection, the pooled OR was 4.72 (95% CI: 3.77-5.92) and 4.31 (95% CI: 2.68-6.94), respectively. The risks of spontaneous abortion and missed abortion recurrence enhanced significantly along with the increasing frequency of UU infection. Conclusion ; There are significant associations between UU infection of reproductive tract and the risks of spontaneous abortion as well as missed abortion. It suggests that the combination of UU quantitative and qualitative detection should be considered in order to prevent the antibiotic misuse in reproductive women.

  3. Expression of B lymphocyte activating factor in decidual and chorionic membranes of women with early spontaneous abortion and its significance%胚胎停育患者蜕膜和绒毛组织中B淋巴细胞刺激因子的表达及意义

    高艳萍; 郝冬梅

    2011-01-01

    目的 探讨胚胎停育患者蜕膜和绒毛组织中B淋巴细胞刺激因子(BAFF)的表达与胚胎停育的关系.方法 随机选择早孕胚胎停育患者30例作为实验组,正常早孕人工流产者30例为对照组.用免疫组化(二步法)法测定蜕膜及绒毛中BAFF的表达情况.结果 BAFF在所有标本中都有表达,但胚胎停育组蜕膜中BAFF的表达均低于对照组(P<0.05),胚胎停育组蜕膜血管内皮中则无表达.结论 BAFF与胚胎停育有一定的关联,可能是导致胚胎停育的原因之一.%Objective To study the correlation between the expression of B lymphocyte activating factor in decidual and chorionic membranes and early spontaneous abortion. Methods Thirty women with early spontaneous abortion served as an experimental group and 30 women who had artificial abortion for normal early pregnancy served as a control group. Expression of B lymphocyte activating factor in decidual and chorionic membranes was detected by immunohistochemistry. Results B lymphocyte activating factor was expressed in all samples of decidual and chorionic membranes. However, its expression level in decidual membrane was lower in experimental group than in control group(P<0.05). B lymphocyte activating factor was not expressed in angioendothelium of experimental group. Conclusion B lymphocyte activating factor is associated with early spontaneous abortion and may be one of the reasons for early spontaneous abortion.

  4. [Abortion-related mortality in Brazil: decrease in spatial inequality].

    Lima, B G

    2000-03-01

    Abortion is not only a major cause of obstetric hospitalization in poor countries, but it also represents the failure of the public health system to provide enough information about contraceptive methods and thus prevent pregnancies. In Brazil, the high utilization rates of health facilities due to abortions reflect the ongoing difficulties with family planning and contraception. In addition, mortality resulting from abortions serves as an indicator of the quality of abortion procedures, an important point in a country where the practice is illegal and therefore done clandestinely. In this study, we analyzed the rates of mortality resulting from abortions among women 10 to 54 years old, including women who died from spontaneous and induced abortion, from 1980 to 1995, for the various regions of the country. The information we used came from the mortality data bank of the public health system of the Ministry of Health. Population data were obtained from the Brazilian Institute for Geography and Statistics. We studied 2,602 deaths, 15% of which were due to missed abortion, spontaneous abortion, or legally permitted induced abortion. The other 85% of the deaths were due to illegal induced abortions or to nonspecified abortions. The mortality rates from abortion-related causes have steadily decreased in all the regions of Brazil, but this improvement has been unevenly distributed in the country. The region with the smallest decrease in this rate (38% over 15 years) was the Northeast. The age of women dying from abortions progressively declined over the period studied.

  5. 某石化企业育龄女工自然流产的病例对照研究%A case-control study of spontaneous abortion among female workers in a petrochemical enterprise

    李学庆; 唐怀青

    2012-01-01

    [Objective]To understand the factors influencing spontaneous abortion among female workers in petrochemical enterprises, and provide scientific evidence for developing control measures and reducing the spontaneous abortion prevalence. [Methods] Matched case-control study was adopted in the study. A respective survey was conducted on 156 female workers in a large petrochemical enterprise of Nanjing who had spontaneously abortion in recent 3 years by trained investigator. Fertile married women who had physical examination in the Center for Disease Control and Prevention matched for age with 1:1 ratio were selected as control group. The same questionnaire was adopted in both control group and case group. [ Results] The analysis of multiple logistic regression indicated that monthly income of family, menses, pets, work intensity, benzene and benzene homologues, heavy metal, seniority , noise and vibration had significant correlation with spontaneous abortion among female workers.. Monthly income of family was protection factor, but menses, pets, work intensity, benzene and benzene homologues, heavy metal, seniority, noise and vibration were risk factors (the OR were 1. 865, 4. 603, 1. 643, 11. 445, 4. 114, 4. 740, 3. 936, 2. 765, respectively). [Conclusion]This study had identified many kinds of factors correlated with spontaneous abortion among female workers. In order to improve the reproductive health and population quality of next generation, more health education of healthy childbearing should be improved and petrochemical enterprise female workers should leave job with occupational hazards exposure in the period of pregnancy.%目的 了解石化企业育龄女工自然流产发生的影响因素,为制定防制措施、减少自然流产的发生提供科学依据.方法 采用配对病例对照研究设计,由经培训的调查员选取南京市某大型石化生产企业3年期间发生的156例自然流产者进行回顾性问卷调查.对照组在市疾病

  6. Abortion ethics.

    Fromer, M J

    1982-04-01

    Nurses have opinions about abortion, but because they are health professionals and their opinions are sought as such, they are obligated to understand why they hold certain views. Nurses need to be clear about why they believe as they do, and they must arrive at a point of view in a rational and logical manner. To assist nurses in this task, the ethical issues surrounding abortion are enumerated and clarified. To do this, some of the philosophic and historic approaches to abortion and how a position can be logically argued are examined. At the outset some emotion-laden terms are defined. Abortion is defined as the expulsion of a fetus from the uterus before 28 weeks' gestation, the arbitrarily established time of viability. This discussion is concerned only with induced abortion. Since the beginning of recorded history women have chosen to have abortions. Early Jews and Christians forbade abortion on practical and religious grounds. A human life was viewed as valuable, and there was also the practical consideration of the addition of another person to the population, i.e., more brute strength to do the necessary physical work, defend against enemies, and ensure the continuation of the people. These kinds of pragmatic reasons favoring or opposing abortion have little to do with the Western concept of abortion in genaeral and what is going on in the U.S. today in particular. Discussion of the ethics of abortion must rest on 1 or more of several foundations: whether or not the fetus is a human being; the rights of the pregnant woman as opposed to those of the fetus, and circumstances of horror and hardship that might surround a pregnancy. Viability is relative. Because viability is not a specific descriptive entity, value judgments become part of the determination, both of viability and the actions that might be taken based on that determination. The fetus does not become a full human being at viability. That occurs only at conception or birth, depending on one's view

  7. Effects of miscarriage prevention with Chinese herbs for 60 recurrent spontaneous abortion patients%60例复发性流产患者中药安胎治疗的疗效观察

    刘新玉; 黄长盛; 罗颂平

    2013-01-01

    Objective It is to analyze the effects of miscarriage prevention with Chinese herbs for recurrent spontaneous a-bortion( RSA) patients, so as to provide reference for the necessity of treating USA with Chinese herbs. Methods 60 cases of patients were treated with miscarriage prevention of Chinese drugs according to the syndrome differentiation types. The number of cases with threaten abortion symptoms before and after treatment and the symptom improvement rate were calculated, the differentiation of serum β - HCG and P levels between the two stages were compared, and the effective ratio of miscarriage prevention treatment was counted. Results After miscarriage prevention treatment, the symptom improvement rate of bleeding, waist soreness, abdominal pain and anal bulg was 86% , 83% , 83% and 90% respectively, there was no significant difference in the improving rates of every symptom. The levels of serum β- HCG and P increased after treatment. The effective rati-o for patients had 2 times, 3 times and over 4 times spontaneous abortion history was 94% , 90% and 89% respectively, the differences were not significant. Conclusion Miscarriage prevention with Chinese herbs in the early pregnant stage can relieve the threaten abortion symptoms, elevate patients' serum β- HCG and P levels, so it can play the role of maintaining the pregnancy and preventing the probability of another miscarriage. It' s necessary to precede treatment with Chinese herbs in the early pregnant stage.%目的 分析有复发性流产病史患者再次妊娠后经中药安胎治疗的疗效,为中医药治疗复发性流产的必要性提供参考依据.方法 对60例有复发性流产史再次妊娠患者进行辨证分型,并随症加减给予中药安胎治疗.统计治疗前后先兆流产症状的例数及症状改善率;比较治疗前后β-HCG、P水平,计算安胎妊娠成功率.结果 安胎治疗后,患者阴道流血、腰酸、腹痛、肛门坠胀感症状改善率分别为86

  8. 中西医结合治疗复发性流产的疗效观察%Observation of curative effects of integrated Chinese and western medicines in the treatment of recurrent spontaneous abortion

    陈淑音; 王金英

    2015-01-01

    目的:观察滋肾育胎丸联合地屈孕酮、维生素E治疗复发性流产的疗效。方法选择2011年1月~2013年12月来院就诊的复发性流产患者123例为研究对象,随机分为对照组60例和治疗组63例,对照组患者孕前不用药,孕后给予地屈孕酮、维生素E安胎治疗;治疗组患者孕前用药:每月月经干净后始服滋肾育胎丸直至下次月经来潮停药,连续用药3个月,孕后继续服滋肾育胎丸、地屈孕酮、维生素E安胎治疗;比较两组治疗成功率的差异。结果治疗组孕期出现阴道流血、腰骶酸痛、下腹疼痛或坠胀发生率明显低于对照组,差异有统计学意义(P<0.05)。治疗组成功率92.06%,对照组成功率66.67%,两组比较,治疗组成功率明显高于对照组,差异有统计学意义(P<0.05)。结论采用滋肾育胎丸联合地屈孕酮、维生素E治疗复发性流产安全,成功率高,值得在临床加以推广。%Objective To observe the curative effects of zishen yutai pill combined with dydrogesterone and vitamin E in the treatment of recurrent spontaneous abortion. Methods A total of 123 patients with recurrent spontaneous abortion who were admitted to our hospital from January 2011 to December 2013 were selected as research subjects. They were randomly assigned to a control group of 60 patients and a treatment group of 63 patients. Patients in the control group were not given any medication before pregnancy and were given dydrogesterone and vitamin E after pregnancy for mis-carriage prevention;patients in the treatment group were given medication before pregnancy: patients were given zishen yutai pill from the end of monthly menstruation to the beginning of the next menstruation continuously for 3 months. They were continuously given zishen yutai pill, dydrogesterone and vitamin E after pregnancy for miscarriage preven-tion; difference of successful rate of the treatment between the two groups

  9. FISH技术在检测自然流产胚胎染色体异常中的应用研究%A clinical research on chromosomal abnormality in spontaneous aborted fetuses detected by fluorescent in situ hybridization

    韦红卫; 杜娟; 夏红卫; 蒋丽; 陈科

    2012-01-01

    Objective; To investigate the application value on detection the chromosome abnormalities of chorionic villi tissue of spontaneous abortion by FISH technology. Methods: The chromosomal numerical aberrations were detected in 100 cases of chorionic villi tissue of spontaneous abortion in early pregnancy by using FISH, and some cases results were compared with the parallel experiment with cytogenetic karyotypes analysis. Results; Success rate of FISH detection wasl00% for100 cases of chorionic villi tissue of spontaneous abortion, and 42 of the 100 cases were found chromosomal numerical aberrations, detection rate 42%. 23 of the 100 cases were cultured, the cultural success rate was 91. 30% (21/23), chromosome abnormalities rate was 61. 91% (13/21), 11 case with chromosome aneuploid of 13 cases with chromosome abnormalities account for 84. 61% (11/13). The coincidence rate of the results of FISH detection and cytogenetic karyotypes analysis were 100% , the missed diagnosis rate was 23.08% (3/13). Conclusions ; The results showed that FISH technology was sensitive, highly specific, rapid and low demand for samples and so on, but the missed diagnosis rate was high, and if condition permit, the patient should take FISH detection and cytogenetic karyotypes analysis simultaneously.%目的 探讨FISH技术在检测自然流产绒毛组织染色体异常中的应用价值.方法 采用FISH技术对100例早期妊娠自然流产绒毛进行染色体数目检测,部分病例同时行常规细胞培养核型分析,分析两种方法的诊断结果.结果 100例绒毛标本FISH检测成功率100%,染色体数目异常42例,检出率42.00%.23例标本同时细胞培养,培养成功率91.30% (21/23),核型分析异常染色体比率61.91% (13/21),其中非整倍体占84.61% (11/13).FISH检测结果与染色体核型分析吻合率100%,漏诊率23.08% (3/13).结论 FISH技术具有敏感性高、特异性强、诊断快速、对标本要求低等优势,但漏诊率

  10. 心理联合臭氧治疗自然流产后细菌性阴道病疗效观察%Effect of psychological intervention combined with ozone disinfection on patients of spontaneous abortion with bacterial vaginosis

    吴赪; 余进; 杨兴仁

    2012-01-01

    To evaluate the clinical effects of psychological intervention combined with ozone douching on patients of spontaneous abortion with bacterial vaginosis ( BV ). Methods 157 patients who accepted psychological intervention were randomly divided into treatment group receiving improved ozone vaginal douching, first control group accepting ordinary vaginal douching with ozone water, and second control group treated with metronidazole. The cure rate, total effective rate and recurrence rate of three groups were compared. Results The cure rate and total effective rate of the treatment group was 84. 62% and 98. 08% , respectively, and the recurrence rate was zero. There were statistical differences between the treatment group and control groups ( x2 value was 4. 4183, 4. 5475 and infinity, respectively, all P 0. 05 ). Conclusion Improved vaginal douching with ozone water is significantly better than common douching and traditional treatment in treating BV after spontaneous abortion.%目的 评价心理疏导联合臭氧冲洗治疗自然流产后细菌性阴道病的临床疗效.方法 将157例患者随机分为加用优化臭氧冲洗法的治疗组,加用普通臭氧冲洗的对照1组,加用甲硝唑栓的对照2组,在心理疏导的基础上,比较3组患者的BV治愈率、总有效率和复发率.结果 治疗组治愈率84.62%、总有效率98.08%、无复发,与两对照组比较有显著的统计学差异,χ2值分别为4.4183、4.5475和无穷大,均P0.05.结论 优化臭氧冲洗法治疗自然流产后BV明显优于普通冲洗和传统治疗.

  11. Medical abortion and the risk of subsequent adverse pregnancy outcomes

    Virk, Jasveer; Zhang, Jun; Olsen, Jørn

    2007-01-01

    BACKGROUND: The long-term safety of surgical abortion in the first trimester is well established. Despite the increasing use of medical abortion (abortion by means of medication), limited information is available regarding the effects of this procedure on subsequent pregnancies. METHODS: We...... identified all women living in Denmark who had undergone an abortion for nonmedical reasons between 1999 and 2004 and obtained information regarding subsequent pregnancies from national registries. Risks of ectopic pregnancy, spontaneous abortion, preterm birth (at ... weight (abortion were compared with risks in women who had had a first-trimester surgical abortion. RESULTS: Among 11,814 pregnancies in women who had had a previous first-trimester medical abortion (2710 women...

  12. 补肾健脾方联合孕激素保胎效果分析%The effect of Tonifying-Kidney and Spleen Formula combined with progestin on recurrent spontaneous abortion

    许秀平; 王文君; 归绥琪; 李大金

    2013-01-01

    Objective To analyze the abortion prevention effect of Tonifying-Kidney and Spleen Formula combined with progestin through a comparison of effectiveness and the success rate of abortion prevention with a therapy of single progestin on recurrent spontaneous abortion(RSA)patients.Methods Three hundred and forty eight patients with RSA history suffering from a threatened abortion at the clinic of our hospital were collected from Jan.2009 to Jan.2012.By a clinical study with non-randomized controlled trials,there were a total of 159 patients corresponded with RSA and kidney deficiency diagnostic criteria.They were divided into the treatment group(n =74 cases)and the control group(n =85 cases)based on whether they would like to accept the traditional Chinese medicine(TCM)dialectical therapy.Patients in the treatment group were treated with Tonifying-Kidney and Spleen Formula combined with progestin,while patients in the control group were given the single progestin treatment.Both groups took intervention therapies more than 2 weeks of eldest gestational age of preabortion.Six cases had fall off during the treatment(2 cases in the treatment group and 4 cases in the control group).The progesterone level after the treatment was monitored,to observe and compare the changes of progesterone level in the two groups before and after 2 weeks of treatment as well as adverse effects after taking the medicine.To evaluate the effectiveness rate of abortion prevention that was more than 2 weeks of eldest gestational age of pre-abortion,and the success rate of abortion prevention at follow-up,and the survival rate of embryo or fetus in both groups at different gestational period.Results The progesterone level before treatment was(22.42 ± 6.92)ng/mL in the treatment group,while it was(21.60 ± 7.6)ng/mL in the control group,and the difference between the two groups had no statistical significance(P =0.489).The progesterone level after 2 weeks of treatment was(31.15 ± 9.44)ng/mL in

  13. Cytogenetic and morphologic study of spontaneous abortions products in Medellín, Colombia Estudio citogenético y morfológico en productos de aborto espontáneo procedentes de diferentes servicios de ginecoobstetricia de la ciudad de Medellín

    Bernardo Agudelo Jaramillo; José Luis Ramírez Castro; Carlos Mario Muñetón Peña; Gonzálo Vásquez Palacio

    1998-01-01

    Eighty tour spontaneous abortion products, with gestational age under 20 weeks, were collected in ditterent obstetric and gynecologic services trom Medellin-Colombia between September 1996 and October 1997; they were studied both morphologically and cytogenetically. Sixteen of those products were discarded because of contamination or absence of suitable tissues for the study In 60 of the remaining 68 products (88°/~) cultures for cytogenetic studies were establishedJ and they were succesful i...

  14. 原因不明复发性流产主动免疫治疗质量控制及疗效分析%Quality control and efficacy analysis of immunothreapy for women with unexplained recurrent spontaneous abortions

    苗竹林; 崔蓉; 杨宁; 王一峰; 黄密琼; 张碧云; 秦卫兵; 王小兰; 赵颖

    2013-01-01

    目的:探讨原因不明复发性流产(URSA)主动免疫治疗质量控制以及疗效.方法:对505例URSA患者给予主动免疫治疗,于治疗前、治疗中及治疗后进行严格的质量控制,包括治疗前从业人员培训、患者基本资料的采集、适应证选择、知情同意等,治疗过程中样本采集与保存、实验室无菌操作,免疫治疗后进行疗效评估、随访.结果:经过严格的质量控制,减少了患者的不良反应;治疗中进行再次生育力的评估有利于指导妊娠.再次受孕325例,占免疫治疗人数的67.29%(325/483);未妊娠149例,占30.85% (149/483).妊娠后加强免疫治疗并综合保胎,283例成功妊娠,占受孕总数的87.08%(283/325);42例再次流产,流产率为12.92% (42/325).结论:URSA患者主动免疫治疗质量控制是保证疗效的有效措施.%Objective:To investigate the quality control and efficacy of lymphocyte immunotherapy (LIT) for women with unexplained recurrent spontaneous abortions.Methods:505 women with unexplained recurrent spontaneous abortions (URSA) were immunized with lymphocytes,in the whole process of strict quality control were underwent before,during and after the treatment,including physician training,acquisition of the basic information of the patient's,the indications and informed consent before treatment.Sample collection and preservation,laboratory aseptic technique during treatment,efficacy evaluation and follow-up after treatment were done..Results:483cases accepted lymphocyte immunotherapy.The side effect was reduced through strict quality control,and it was helpful to guide the pregnancy by fertility evaluation again during the treatment.325 patients were again conception,the rate was 67.29% (325/483),149 patients were secondary infertility,the rate was 30.85% (149/483) one year later.After pregnancy,283 patients were successful pregnancy,the rate was 87.08% (283/325) by strengthen the immune therapy and comprehensive

  15. Cervicovaginal aerobic microflora of women with spontaneous abortion or preterm delivery in Araraquara-Brazil Microbiota aeróbica cérvico-vaginal de mulheres com aborto espontâneo ou prematuridade fetal em Araraquara - Brasil

    Maria Stella G. Raddi

    1998-10-01

    Full Text Available Microbiological routine exams of endocervix and vaginal specimens of 22 women with clinical history of recent spontaneous abortion or premature rupture of membranes were accomplished. Chlamydia trachomatis, Streptococcus pyogenes, Streptococcus agalactiae, Candida sp and Gardnerella vaginalis were recovered from 54.5% (12 of the women. Ureaplasma urealyticum was frequently isolated (45.5% but 5 out of 22 had U. urealyticum only. Our report stands for the importance of quantitative as well as qualitative investigation on genital microflora in pregnant women, since it is likely to influence on pregnancy outcome.Rotina bacteriológica do conteúdo vaginal e cervical de 22 mulheres com histórico de aborto recente ou ruptura precoce das membranas foi realizada. Chlamydia trachomatis, Streptococcus pyogenes, Streptococcus agalactiae, Candida sp e Gardnerella vaginalis foram isolados em 54,5% (12 das pacientes. Apesar de Ureaplasma urealyticum ter sido frequentemente encontrado (45,5%, somente em 5 das 22 mulheres foi o único microrganismo presente nos materiais analisados. Esses resultados chamam a atenção para a importância de investigação quantitativa bem como qualitativa da microbiota genital em gestantes, tendo em vista ter consequências na gestação.

  16. 同种免疫型复发性流产的病因及诊治%Etiology, diagnosis and treatment of isoimmune recurrent spontaneous abortion

    赵爱民; 林其德

    2007-01-01

    复发性流产(recurrent spontaneous abortion,RSA)是指自然流产连续发生2次或2次以上者,发生率约1%。RSA的病因除了染色体、解剖、内分泌异常及生殖道感染外,约50%以上患者流产原因不明。近年来的研究表明原因不明的RSA大部分与免疫学异常有关,并将其分为自身免疫异常所致RSA(自身免疫型RSA)和同种免疫异常所致RSA(同种免疫型RSA)两大类。本文就同种免疫型RSA的病因、发病机制及其诊治进行讨论。

  17. 复发性自然流产与易栓症的研究进展%Advance in recurreent spontaneous abortion and the thrombophilia

    宋敏; 许如秀

    2005-01-01

    复发性自然流产(recurrent spontaneous abonion RSA)是指连续发生两次或两次以上的自然流产,是生育期较为常见的疾病,5%的妇女有至少2次或2次以上的自然流产,而且30%~40%的复发性流产是原因不明的。RSA病因复杂,目前较肯定的影响因素有:染色体异常、解剖因素、内分泌异常、免疫因素、血型不合、感染等。近年来国内外研究认为复发性自然流产的妇女具有血栓形成倾向,这种因持续高血凝状态而导致的血栓形成倾向称为易栓症(thrombophilia)也称血栓前状态。

  18. 自然流产患者绒毛组织PAI-14G/5G多态性和uPA基因的表达及其意义%Expression and Clinical Significance of PAI-1 4G/5G Polymorphism and uPA in the Villus of Spontaneous Abortion

    杨玲竹; 瞿小玲; 李亚敏

    2011-01-01

    目的:探讨纤溶酶原激活物抑制剂-1(PAI-1)4G/5G多态性和纤溶酶原激活剂(uPA)与自然流产的关系及其在妊娠中的作用.方法:正常早孕(对照组)人工流产和自然流产(实验组)稽留流产的绒毛组织各30例,应用免疫组织化学PV法检测绒毛组织中PAI-1和uPA蛋白表达情况,等位基因特异性-PCR(AS-PCR)法检测PAI-14G/5G多态性的表达情况,RT-PCR法检测uPA mRNA表达情况.结果:① PAI-1蛋白主要在绒毛组织的滋养细胞质中表达,其表达对照组低于实验组(P<0.05).uPA与PAI-1蛋白在细胞中分布一致,其表达水平对照组高于实验组(P<0.05).②PAI-14G/4G基因型和4G等位基因表达水平对照组低于实验组(P<0.05),uPA mRNA表达水平对照组高于实验组(P<0.05).③PAI-1和uPA蛋白在自然流产患者绒毛组织中的表达呈负相关(r=-0.639).结论:PAI-14G/5G多态性和uPA异常表达可能与自然流产的发生有关.%Objective: To explore the correlation of PAI-14G/5G polymorphism and uPA with spontaneous abortion and their effect during pregnancy. Methods: Each of 30 samples was from the villus of normal pregnancy (control group) and spontaneous abortion (experimental group), respectively. Immunchistochchemistry analysis was used to detect the protein expression of PAI-1 and uPA. AS-PCR analysis was used to detect PAI-1 4G/5G polymorphism expression and RT-PCR analysis was used to detect uPA mRNA expression. Results: 1) The expression of PAI-1 protein in spontaneous abortion villus was higher than that of normal pregnancy (P< 0.05)and it was mainly expressed in the trophocyte cytoplasm. The expression of uPA protein in spontaneous abortion villus was lower than that of normal pregnancy (P<0.05) and it's distribution was consistent with the PAI-1.2)The frequencies of 4G/4G genotype and 4G alleles of PAI- 1 were signicantly higher in abortions compared with the control. The expression of uPA mRNA was significantly lower in abortions

  19. The impact and predictive value of maternal thyroid function on spontaneous abortion in the first trimester of pregnancy%妊娠早期甲状腺功能及其抗体对自然流产的影响和预测价值

    闫梅; 王晓银; 毕烨; 罗真; 温琦; 张琳琳

    2016-01-01

    目的:探讨妊娠早期甲状腺功能及抗体对自然流产的影响及预测价值。方法选择2014年1~6月因早孕于四川省妇幼保健院检查并同意参加调查的621名育龄妇女的临床资料,常规筛查甲状腺功能,包含血清促甲状腺素( thyroid stimulating hormone,TSH)、血清游离甲状腺素( free thyroxine,FT4)、血清游离三碘甲状腺原氨酸( free triiodothyronine,FT3)及甲功抗体( thyroid auto-antibodies, TA-Ab),并追踪随访至妊娠结束570例。根据TSH的水平分成3组:TSH减低组12例(TSH2.5 mlU/L)。根据甲状腺过氧化物酶抗体( thyroid peroxidase antibody, TPOAb)和甲状腺球蛋白抗体( thyroglobulin antibody, TgAb)水平分为两组:TPOAb≥34 IU/mL或TgAb≥115 IU/mL为TA-Ab阳性组(45例);TPOAb2. 5 mlU/L ) , including 288 cases. According to the TPOAb and TgAb level, divided them into two groups:TA-Ab positive group ( TPOAb≥34 IU/ml or TgAb≥115 IU/mL) ,including 45 cases, TA-Ab negative group ( TPOAb<50 IU/mL and TgAb<115 IU/mL), including 525 cases. Evaluated the impact and the predictive value of the different levels of thyroid function and thyroid antibody on spontaneous abortion. Results The rate of spontaneous abortion of the TSH increased group was up to 21. 88 % which was obvious higher than that of TSH normal group (P=0. 006). The rate of spontaneous abortion of TA-Ab positive group was 66. 67 %, TA-Ab negative group was 10. 88 %, the difference was statistically significant ( P =0. 000 ) . The rate of spontaneous abortion was 71. 43 % in the cases of both increased TSH and positive TA-Ab, and the rate was only 8. 60 % in the cases of normal TSH, the difference was statistically significant ( P =0. 000 ) . The area of ROC curve about TA-Ab and TSH prediction of spontaneous abortion was 0. 657 and 0. 714, the difference was statistically significant (P =0. 007, P =0. 000). Conclusion Serum TSH increased during the first trimester of pregnancy and positive thyroid

  20. Investigation on relation between recurrent spontaneous abortion and antiphospholipid thrombosis syndrome%复发性自然流产与抗磷脂血栓综合征相关性探讨

    雷蕾; 周志中

    2001-01-01

    目的探讨复发性自然流产(RSA)的原因,了解其与抗磷脂血栓综合征(APL-T)的关系。方法采用ELISA法和PTT-LA法对32例复发性流产及20例正常对照进行抗心磷脂抗体(ACA)和狼疮抗凝物(LA)检测。结果 32例RSA患者中17例APA阳性,阳性率(53.1%)明显高于对照,其中LA阳性率为28.1%,亦明显高于对照。8例诊断为抗磷脂血栓综合征。结论 APA中之LA可能是RSA发生的重要原因,对不明原因的复发性自然流产可考虑为抗磷脂血栓综合征。%Objective To investigate the causes of recurrent spontaneous abortion(RSA) and to know the relation between RSA and antiphospholipid thrombosis syndrome(APL-T). Methods ELISA and PTT-LA were used to detect anticardiolipin antibody(ACA) and lupus anticoagulant(LA) in 32 patients with RSA and 20 normal controls(NC). Results There were 17 positive of antiphospholipid antibody(APA) in RSA group. The incidence was significantly higher than that in NC group. The incidence of LA was also significantly higher than that in NC group. 8 patients were diagnosed as APL-T. Conclusion LA may be the more important reason of RSA. It should be considered as APL-T when RSA is unexplained.

  1. CD107a Expression and IFN-γ Production as Markers for Evaluation of Cytotoxic CD3+ CD8+ T Cell Response to CMV Antigen in Women with Recurrent Spontaneous Abortion

    Batoul Tarokhian

    2014-01-01

    Full Text Available Background: Some evidence has shown a relationship between primary human cytomegalovirus (CMV infection and pregnancy loss. The impact of CMV infection reactivation during pregnancy on adverse pregnancy outcomes is not completely understood. It is proposed that altered immune response, and therefore, recurrence or reactivation of latent CMV infection may relate to recurrent spontaneous abortion (RSA; however, few data are available in this regard. To find out about any cell mediated defect and reactivation of latent CMV infection in women with RPL, cellular immunity to the virus has been evaluated by specific cytotoxic T lymphocyte (CTL response to CMV. Materials and Methods: In a case control study, CTL CD107a expression and intercellular IFN-γ production in response to CMV pp65 antigen and staphylococcus enterotoxin B (SEB in women with RSA were assessed by flow cytometric analysis. Forty-four cases with history of recurrent pregnancy and forty-four controls with history of successful pregnancies were included. The FACSCaliber flow cytometer were used for analysis. Results: No significant difference was observed between CD107a expression and IFN-γ production in response to CMV PP65 antigen in RPL patients and control group. However, the cytotoxic response to SEB antigen in patients with RPL was significantly lower than control group (p=0.042. Conclusion: The results of this study show that impaired CD107a expression and IFN-γ production as CTL response to CMV does not appear to be a major contributing and immune incompetence factor in patients with RPL, but cytotoxic T cell response defect to other antigens requires to be assessed further in these patients.

  2. The research development of vascular factors in recurrent spontaneous abortion%血管相关因素在复发性流产中的研究进展

    王珊; 于彩虹; 李肖肖; 刘梅梅

    2016-01-01

    Recurrent spontaneous abortion (RSA) was one of the most difficult infertile diseases which was usually defined as consecutive still birth for more than three times during the first 20 weeks of gestation. Various factors and pathogeneses were thought to play a role in RSA. Recent studies had indicated that the disorders of blood vessel growth and the secondary abnormal blood perfusion may contribute to the occurrence of RSA. However, blood vessel growth was linked with the regulation of angiogenesis related factors. To provide references for the clinical prevention and treatment, the purpose of this paper was to evaluate the association between solubility vascular endothelial growth factor receptor-1(sflt-1), thrombospondin 1(TSP-1) and ovary, endometrial abnormal blood perfusion in cases of RSA.%复发性流产(RSA)是指与同一性伴侣连续发生3次或3次以上在妊娠20周前的胎儿丢失者,是临床上难处理的不育症之一。其病因及发病机制多样,近年的研究表明妊娠过程中卵巢、子宫内膜血管生长紊乱及其所致的异常血流灌注可导致RSA,而血管的生长受血管相关因子的调控。本文就血管相关因子可溶性血管内皮生长因子受体-1(sflt-1)、血小板反应蛋白-1(TSP-1)及卵巢、子宫内膜异常血流灌注在RSA中的作用做一综述,为临床提供参考。

  3. 孕产妇复发性流产与胰岛素抵抗相关性Meta分析%Meta-analysis of the relationship between recurrent spontaneous abortion and insulin resistance

    朱芬芳; 赵荷兰; 郑彤彤

    2015-01-01

    Objective To explore whether insulin resistance (IR) increases maternal recurrent spontaneous abortion (RSA) by meta-analysis of published articles at home and abroad with randomized case-control study. Methods Literatures on case-control study on relationship between RSA and IR published during the period of January 1996 to January 2014 were retrieved in PubMed, Embase, Springer link, Chinese Biomedical Literature Database with computer and other journals by hand, and they were screened with set standard and grouped for analysis. Meta-analysis was conducted for the relationship between them. Results Totally 6 articles were selected into the study. There were 432 pregnant women in RSA group and 383 cases in control group ( no abnormal pregnancy history was found) . Under the condition of no significant difference in fasting glucose level, fasting insulin value elevated and isletβ-cell function was impaired more severely in RSA group. IR index was higher in RSA group, which suggested that most of cases with IR index higher than 4. 5 were from RSA group, and the difference was significant (OR=3. 16, 95%CI:1. 7-6. 8,I2 =1. 157,P4.5的患者大多来自RSA组,差异具有统计学意义(OR=3.16,95%CI为1.7~6.8,I2=1.157,P<0.05)。结论 IR与RSA间存在一定相关性,其可能为RSA的原因之一。

  4. The glutathione S-transferases gene in the risk of recurrent spontaneous abortion%谷胱甘肽S-转移酶基因与复发性流产

    宗晨; 向卉芬; 陈大蔚; 曹云霞

    2013-01-01

    复发性流产(recurrent spontaneous abortion,RSA)是妊娠中常见的临床并发症之一,也是一直困扰医生和患者的一个难题,RSA不仅对患者的身体健康造成了危害,还严重影响了他们的家庭幸福。RSA是一种多因素疾病,病因复杂,其发病受遗传因素,环境因素及生活方式(如饮酒,咖啡及吸烟)等多方面的共同影响。近年来,有报道认为氧化应激(oxidative stress,OS)是RSA发病的高危因素之一,其中谷胱甘肽S-转移酶(glutathione S-transferases,GSTs)是体内氧化/抗氧化系统的重要成员,在体内活性氧产物(reactive oxygen species,ROS)的代谢中发挥重要作用。若GSTs的表达或功能出现异常,将会导致胚胎及胎盘暴露于内源性及外源性有害物质的损伤而导致流产。现将 GST基因与 RSA 发病的相关性研究做一综述。%Recurrent spontaneous abortion (RSA) is a common and frustrating pregnancy complication. RSA not only has an adverse effect on the patients' health, but also brings the patients' families great pain. RSA is a multifactor disorder. Multiple factors including genetic factors, environment, habits and customs, such as cigarette smoking, the consumption of alcohol and coffee, have effect on the development of RSA. Accumulating studies have suggested that oxidative stress (OS) may be one of the risk factors of RSA in recent years. In the oxidant/antioxidant system in vivo, glutathione S-transferases (GSTs) play an important role in the detoxification of reactive oxygen species (ROS). The genetic variant of the GST gene could lead to the abnormal expression and function of GSTs, as a result, increased exposure of the conceptus to the exo- and endogenous toxins might contribute to the development of RSA. In this review, we will focus on the role of GST gene in the development of RSA.

  5. FISH技术检测自然流产或死胎死产组织中染色体异常的临床研究%Clinical study of chromosomal abnormality in spontaneous abortion tissue or stillbirth tissue detected by fluorescence in situ hybridization technique

    崔洪艳; 陈叙; 岳天孚

    2011-01-01

    Objective; To explore the total incidence of chromosomal abnormality, types of chromosomal abnormality and incidences of various chromosomal abnormalities in spontaneous abortion tissue or stillbirth tissue. Methods; Centromere probes of 18, X and Y chromosomes and single sequence probes of 13, 16, 21 and 22 chromosomes were used for fluorescence in situ hybridization (FISH) detection among 100 samples of spontaneous abortion tissue or stillbirth tissue. Results; 55% of spontaneous abortion or stillbirth were caused by fetal chromosomal abnormality; the top three types of chromosomal abnormality were trisomy 16, trisomy 22 and triploid, accounting for 34. 88% , 16. 28% and 11. 63% of the total number of chromosomal abnormality, respectively. Conclusion; Most spontaneous abortion or stillbirth are caused by genetic gene defect, FISH technique can detect aborted fetuses, find chromosomal abnormality rapidly and accurately, provide data for genetic counseling of subsequent pregnancy.%目的:探讨自然流产或死胎死产胎儿组织细胞中染色体异常总发生率及异常种类和各种异常的发生率.方法:采用18号、X和Y染色体着丝粒探针及13、16、21、22号染色体单一序列探针,对100例自然流产或死胎死产胎儿组织进行FISH检测.结果:55%的自然流产或死胎死产是由胎儿染色体异常引起的;染色体异常的前3位为16-三体综合征、22-三体综合征和三倍体,分别占染色体异常总发生数的34.88%、16.28%和11.63%.结论:自然流产或死胎死产多由遗传基因缺陷引起,应用FISH技术检测流产胚胎,可以快速、准确发现较常见的染色体异常,为下一胎妊娠进行遗传咨询提供资料.

  6. Impact of intravenous immunoglobulin on peripheral blood natural killer cells in women with recurrent spontaneous abortion%复发性流产患者注射免疫球蛋白对NK细胞的影响

    滕奔琦; 张媛; 魏方; 李玲; 范建辉

    2013-01-01

    Objective To explore the impact of intravenous immunoglobulin on peripheral blood natural killer (NK) cells in women with recurrent spontaneous abortion (RSA).Methods Of 38 patients with RSA who had been hospitalized during the period of January 2011 to June 2012,18 patients received intravenous immunoglobulin (study group) while the rest 20 who refused to receive immunoglobulin were assigned to a control group.Peripheral NK cell cytotoxicity and rate of NK cells in all types of lymphocytes were detected before and after treatment by flow cytometry.Results NK cell cytotoxicity was(22.4 + 7.9)% in the study group and (21.7 ± 8.1)% in the control group before treatment,was (15.0 ± 4.2)% in the study group and (25.6 ± 7.9)% in the control group after treatment.Before treatment,the rate of NK cell was (25.1 ± 9.4) % in the study group and (24.0 ± 9.0) % in the control group,while after treatment it was (26.2 ± 8.7) % in the study group and (23.6 ± 6.8) % in the control group.NK cell c.vtotoxicity but not the rate of NK cell was significantly reduced (P<0.05) in the study group.After treatment,NK cell cytotoxicity and the rate of NK cell did not differ significantly (P>0.05).88.9% of the patients in the study group but 55.0% of the patients in the control group had pregnancy duration of longer than 24 weeks after tocolytic treatment (P<0.05).Conclusions Intravenous immunoglobulin can reduce NK cell cytotoxicity,leading to an increase in the success rate of miscarriage prevention in patients with recurrent spontaneous abortion.%目的 探讨复发性流产(recurrent spontaneous abortion,RSA)患者静脉滴注免疫球蛋白对其外周血NK细胞的影响.方法 2011年1月至2012年6月在我院住院的RSA患者共38例.其中18例静脉滴注免疫球蛋白(IVIG)治疗,作为研究组;20例不同意使用免疫球蛋白治疗的RSA患者作为对照组.比较两组患者外周血NK细胞毒性及NK细胞在所有

  7. 国产荧光原位杂交探针检测自然流产绒毛染色体的临床应用研究%Clinical application and study of domestic fluorescence in situ hybridization in detection of chromosome in chorionic tissue of cases with spontaneous abortion

    胡红霞; 丛林; 袁静; 赵保静; 方慧琴; 陈薇

    2011-01-01

    Objective; To cany out genetic analysis of chorionic tissue of cases with spontaneous abortion by using domestic fluo-rescence in situ hybridization ( FISH) probe. Methods: 80 samples of chorionic tissue after spontaneous abortion and 20 samples of chorion-ic tissue after spontaneous abortion treated with in vitro fertilization - embryo transfer (IVF - ET) were collected, FISH technique was used to analyze the heteroploid conditions of five pairs of autosome (13, 16, 18, 21, 22) and one pair of sex chromosome ( X and Y) , then the results were compared with cell culture karyotype analysis technique. Results; 30 cases with chromosomal abnormality were detected by FISH technique, and 38 cases with chromosomal abnormality were detected by cell culture karyotype analysis technique; the incidences of chromo-somal abnormality in spontaneous abortion group and FVF - ET abortion group were 38.75% (31/80) and 35.00% (7/20), respectively, there was no significant difference between the two groups ( P > 0.05 ) . In spontaneous abortion group, the incidences of chromosomal ab-normality in cases without the history of spontaneous abortion, the cases with the histories of spontaneous abortion for once, twice, three times and more than three times were 28. 30% (15/53) , 30.00% (3/10), 30. 00% (3/10) and 33. 33% (1/3) , respectively, there was no significant difference among different groups; in spontaneous abortion group, the incidences of chromosomal abnormality in cases less than 35 years and more than 35 years were 38. 23% (26/68) and 41. 67% (5/12), respectively; in IVF - ET abortion group, the incidences of chromosomal abnormality in cases less than 35 years and more than 35 years were 21. 43% (3/14) and 66. 67% (4/6) , respectively, in the two groups, there was no significant difference between the two age groups (P >0.05 ) . Conclusion; The occurrence of spontaneous a-bortion after natural pregnancy and IVF - ET are both related to chromosomal abnormality closely, but

  8. Conceptualising abortion stigma

    A. Kumar; L. Hessini; E.M.H. Mitchell

    2009-01-01

    Abortion stigma is widely acknowledged in many countries, but poorly theorised. Although media accounts often evoke abortion stigma as a universal social fact, we suggest that the social production of abortion stigma is profoundly local. Abortion stigma is neither natural nor 'essential' and relies

  9. 生殖道解脲支原体感染与胚胎停育和反复自然流产关联的meta分析%A meta-analysis of ureaplasma urealyticum infection of reproductive tract in women with early pregnant failure and recurrent spontaneous abortion

    裴丽君; 王亚菲; 刘向国; 陈华; 卜雯婷; 王佳; 刘亚芳; 郑晓瑛

    2011-01-01

    目的:评价早孕妇女生殖道解脲支原体感染与胚胎体育和反复自然流产发生的风险关联性.方法:在全面回顾文献基础上,分别对检索到的胚胎停育和反复自然流产文献进行数据整理,用Mantel-Haenszel法合并OR值,并进行meta分析.结果:meta分析表明,妇女生殖道解脲支原体感染发生胚胎停育的合并OR值为3.62(95%CI:2.80~4.67),发生反复自然流产的合并OR值为5.66(95%CI:4.46~7.18);有有解脲支原体感染史的妇女中,胚胎停育和反复自然流产的发生风险随着其复发次数的增加发生风险逐渐加强.结论:妇女生殖道解脲支原体感染与胚胎停育和反复自然流产之间存在关联,其强度随着复发次数的增加而逐渐加强.有效治疗生殖道解脲支原体感染,对预防育龄妇女不良妊娠结局的再次发生具有重要作用.%Objective: To evaluate the efficacy of association between the risk of early pregnant failure and recurrent spontaneous abortion and ureaplasma urealyticum (UU) of reproductive tract infections.Methods: Based on a comprehensive review of literatures, meta- analyses were performed to analyze the data collected from the literatures on early pregnant failure and recurrent spontaneous abortion.A meta- regression analysis was conducted using restricted estimation of maximum likelibood.Odd ratios (OR) was pooled using Mantel - Haenszel method.Results: The risks of early pregnant failure and recurrent spontaneous abortion wereasseciated with UU infection of reproductive tract, the pooled OR were 3.62 (95% CI 2.80 - 4.67 ) and 5.66 (95% CI 4.46 -7.18), respectively.The risks of early pregnant failure and recurrent spontaneous abortion enhanced significantly along with the increasing frequency of UU infection.Conclusion: There was a significant association between the risk of early pregnant failure and recurrent spontaneous abortion and UU infection of reproductive tract, and the association degree

  10. Relationship between Polymorphism of Interleukin-1 Receptor Antagonist Gene And Recurrent Spontaneous Abortion%白细胞介素1受体拮抗剂基因多态性与复发性自然流产的关联性研究

    张静; 包俊华; 赵学峰; 刘芳; 王国平; 陆宏; 党洁; 霍正浩

    2012-01-01

    Objective To investigate the relationship between polymorphism of tandem repeat(VNTR) polymorphism in intron 2 of interleukin - 1 receptor antagonist (IL - Ira) gene and recurrent spontaneous abortion. Methods 191 recurrent spontaneous abortion patients and 193 normal subjects were recruited in the study. Their VNTR polymorphisms of IL - Ira gene were analyzed using polymerase chain reaction method. Results The frequencies of the five genotypes were as follows: IL - 1RN* 1/1,75. 39% ; IL - 1RN* 1/2, 20. 42% ;IL - 1RN* 1/3,0 ;IL - 1RN* 1/4,1.05% ;IL - lRN*2/2,3. 14% in recurrent spontaneous abortion patients and IL -1RN* 1/1,83. 94% ; IL -1RN* 1/2,11.92% ; IL -1RN* 1/3,1. 04% ; IL - 1RN* 1/4, 2. 07% ;IL - 1RN* 2/2,1. 04% in normal subjects, respectively. The frequency of IL - 1RN* 1 and IL -1RN*2 in recurrent spontaneous abortion patients was significantly higher than that in normal controls. Conclusion Allele IL - 1RN * 2 of the interleukin - 1 receptor antagonist gene was related potentially with recurrent spontaneous abortion.%目的 探讨白细胞介素1受体拮抗剂(Interleukin-1 Receptor Antagonist,IL-1Ra)基因多态性与宁夏汉族复发性自然流产(Recurrent Spontaneous Abortion,RSA)的相关性.方法 应用聚合酶链反应 (Polymerase Chain Reaction,PCR)技术检测191例反复自然流产患者和193例健康对照IL-1RN第二内含子中可变串联重复序列(Variable Number of Tandem Repeats,VNTR)多态性.结果 RSA组和对照组IL-1RN*1/1、IL-1RN*1/2、IL-1RN*1/3、IL-1RN*1/4、IL-1RN*2/2基因型频率分别为75.39%、20.42%、0、1.05%、3.14%和83.94%、11.92%、1.04%、2.07%、1.04%;等位基因IL-1RN*1、IL-1RN*2的频率分别为86.13%、13.35%和91.45%、6.99%,两组间差异有统计学意义(P<0.05).携带有IL-1RN*2等位基因的个体发生复发性自然流产的危险性显著高于携带IL-1RN*1的个体(OR=2.03,95%CI:1.242~3.308).结论 IL-1RN*2可能与宁夏汉族复发性自然流产的遗传易感性有关.

  11. Clinical research on treating recurrent spontaneous abortion with Shoutai Wan plus active immunization%寿胎丸加味配合主动免疫治疗反复自然流产的临床研究

    高倩倩; 马永; 张华; 王祖龙

    2014-01-01

    To observe the clinical efficacy of Shoutai Wan plus active immunization on treating recurrent spontaneous abortion. Methods:80 patients were randomly divided into two groups. The control group was given active immunization treatment solo, and another was given Shoutai Wan more. Results:The total efficacy was 82.50%in the treatment group, better than 62.50%in the control;CD3+, CD4+, CD8+ cell subsets in two groups were higher than before (P<0.05), and CD3+, CD8+ in the treatment group were better (P<0.05). There were no obvious side effects. Conclusion: Shoutai Wan plus active immunization come with confirmed clinical efficacy for RSA, it can effectively prevent abortion, and with relatively high safety.%目的:观察运用寿胎丸加味配合主动免疫的方法在治疗反复自然流产(RSA)方面的临床疗效。方法:按随机数字表法(1∶1)将我院近几年生殖门诊80例反复自然流产的患者随机分为两组,各40例。对照组给予单纯主动免疫治疗,治疗组在对照组的基础上给予寿胎丸,8周为1个疗程。观察治疗前后CD3+、CD4+、CD8+细胞亚群比例并比较其差异性。结果:两组总有效率为82.50%和62.50%,两组临床疗效比较,Z=-4.071,P=0.000,治疗组优于对照组;两组患者治疗后 CD3+、CD4+、CD8+细胞亚群均较前升高(P<0.05),且治疗组CD3+、CD8+优于对照组(P<0.05),两组CD4+比较无统计学差异。两组均无明显毒副作用。结论:寿胎丸加味配合主动免疫的方法在治疗RSA方面的临床疗效好,能够有效预防流产发生,且安全性比较高。

  12. 应用定量荧光PCR检测自然流产绒毛染色体非整倍体%Detection of chromosome aneuploidies in spontaneous abortion villus samples by quantitative fluorescence PCR

    武真真; 刘宁; 赵勇江; 赵振华; 孔祥东

    2016-01-01

    Objective To assess the value of quantitative fluorescence polymerase chain reaction(QF-PCR) for the detection of chromosomal aneuploidies in chorionic villus samples from early abortion.Methods One hundred seventy seven specimens were collected.Genomic DNA was extracted,and aneuploidies of 8 chromosomes(13,15,16,18,21,22,X and Y) were detected by QF-PCR analysis.Results The QF-PCR was successful in 176(99.4%) of the cases.All detection was completed in 48 hours.Sixty three (35.8%) cases have shown abnormal signals,which included 3 cases of trisomy 13,3 cases of trisomy 15,14 cases of trisomy 16,2 cases of trisomy 18,7 cases of trisomy 22,3 cases of trisomy 21,13 cases of 45,X,1 case of 47,XXX,2 cases of 47,XXY,2 cases of haploidy,11 cases of triploidy,1 case of trisomy 16 and trisomy 22,1 case of trisomy 21 and trisomy 22.Trisomy 16 was the most common chromosome aneuploidy (22.22%),which was followed by 45,X (20.63%),triploidy (17.46%) and trisomy 22 (11.11%).Conclusion QF-PCR is a quick and easy method for detecting chromosomal aneuploidies in chorionic villi tissue.The results can provide important information for genetic counseling for spontaneous abortions.%目的 探讨定量荧光聚合酶链反应技术(quantitative fluorescent polymerase chain reaction,QF-PCR)对于早期自然流产绒毛染色体非整倍体检测的价值.方法 因自然流产而清宫的绒毛组织标本177份,应用基因组DNA提取试剂盒提取绒毛标本中DNA,针对13、15、16、18、21、22号和X、Y染色体行QF-PCR分析.结果 在177份标本中,成功检测176份(99.4%),QF-PCR检测均在48 h得出结果.其中检测结果正常114份(64.2%),检测出异常信号63例(35.8%),其中3例13-三体、3例15-三体、14例16-三体、2例18-三体、7例22-三体、3例21-三体、13例45,X、1例47,XXX、2例47,XXY、2例单倍体、11例三倍体、1例16-和22-三体、1例21-和22-三体.早期胚胎流产物最常见的非整倍体异常依次为16

  13. The effect of abortion on outcome of subsequent pregnancy

    Abortion

    1999-08-01

    Full Text Available In a historical cohort study we evaluated the effects of spontaneous abortion on subsequent pregnancy outcome. 1693 pregnant women were classifield in three groups: 1100: without any prior pregnancy, group 1; 550: with history of one spontaneous abortion (G2A1, group 2; 43: with two or more prior spontaneous abortions and no other prior pregnancies, group 3. We collected data through interview, patient's records and physical examination. We matched the patients according to their age subgroups, history of chronic disease, drug administration and radiation during current pregnancy and familial marriage. Then we compared adverse outcome of present pregnancy in group 1 and 2 with the women without prior pregnancy. We analysed the data with Chi-square and Fisher's exact methods. In this study we concluded that history of one spontaneous abortion had no effect on subsequent pregnancy except on prolonged ROM (P<0.000, but history of two or more abortions significantly affects occurrence of stillbirth (RR=29, P=0.003 and placenta previa (RR=8.5, P=0.03. These findings suggest that pregnant women with history of two or more spontaneous abortion need special prenatal care.

  14. Effect of Recurrent Spontaneous Abortion on Pregnancy Outcomes in Sequent Successful Pregnancy Patients%复发性流产患者成功妊娠后妊娠结局研究

    李艳芳; 李相宜; 罗颂平

    2015-01-01

    Objective To compare the difference of pregnancy outcomes between women who had a history of recurrent spontaneous abortion ( RSA) and women who were primigravida. Methods A case-control study was carried out. A total of 98 cases with a history of RSA and giving birth in the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January of 2010 to September of 2014 served as the case group, while 98 primigravida giving birth at the same period in the same hospital were randomly selected as controls. The information collection form was designed following literature review before the research. All of the available data, including maternal demographic, reproductive information, medical history and present pregnancy outcomes, were collected from in-patient medical records. The number of valid information forms in case group was 91 and was 94 in control group after excluding the forms with incomplete data. The data was analyzed with SPSS 16.0 software. Results Univariate analysis results showed that maternal age, marital status, distribution of ABO blood groups, the history of infertility, clinical manifestation of threaten abortion, miscarriage treatment during pregnancy, medication of Zishen Yutai Pills for preventing miscarriage, time of delivery, adverse pregnancy outcome, and newborn sex were statistically significant different between the two groups ( P<0.05) . Logistic regression analysis results showed that there were significant differences in 5 factors between the two groups. Maternal age ( OR=1.466, 95%CI=1.267-1.698) , medication of Zishen Yutai Pills for preventing miscarriage ( OR=4.484, 95%CI=1.073-18.519) , and adverse pregnancy outcome ( OR=8.850, 95%CI=2.994-26.316) were the risk factors of RSA. Set blood type O as the classification reference, blood type A was a protective factor ( OR=0.259, 95%CI=0.088-0.765). And newborn sex was another protective factor of RSA ( OR=0.336, 95%CI=0.139-0.813). Conclusion Older women or women with

  15. Physician provision of abortion before Roe v. Wade.

    Joffe, C

    1991-01-01

    With the possibility of the Supreme Court overturning the landmark Roe v. Wade (1973) case legalizing abortion, a review of abortion practices pre-Roe is instructive. Abortion became criminalized in the US around 1870, yet many abortions were performed. While estimates for the yearly number of pre-Roe illegal abortions roughly resemble today's number of legal abortions, the difference between legal and illegal abortion rests in the difference between the large number of women who died or were injured then, and the very few women who now die from illegal abortions. Along with the self-induced abortion, different categories of providers performed illegal abortions: physicians, nonphysicians, nurses, midwives, and lay people; all with varying skill, experience, and motives. While there were "butchers" and sexual exploiters, there were also competent, beloved physicians. There were the financially motivated physicians providing abortions full time, and the occasional providers acting with a sense of conscience, risking successful practices and jail. Within this "conscience" group of 44 interviewees gathered through personal networks, ads, etc., abortions were: performed outside of hospitals, reducing the risk of discovery, but creating greater medical risks; begun outside of a hospital with the intrusion into the uterus of an object, provoking a "spontaneous abortion" (miscarriage) needing completion by D and C (dilation and curettage) within a hospital, but only a limited number of such patients could be referred before arousing suspicion; and in a hospital under disguised circumstances, a very tricky undertaking with severe limitations, available only a few times before risking detection. Avoidance and lack of training by today's physicians and the well organized antiabortion groups will undoubtedly make illegal abortions even more difficult to engage in than the pre-Roe days.

  16. Post abortion contraception.

    Gemzell-Danielsson, Kristina; Kopp, Helena Kallner

    2015-11-01

    A safe induced abortion has no impact on future fertility. Ovulation may resume as early as 8 days after the abortion. There is no difference in return to fertility after medical or surgical abortion. Most women resume sexual activity soon after an abortion. Contraceptive counseling and provision should therefore be an integrated part of the abortion services to help women avoid another unintended pregnancy and risk, in many cases an unsafe, abortion. Long-acting reversible contraceptive methods that includes implants and intrauterine contraception have been shown to be the most effective contraceptive methods to help women prevent unintended pregnancy following an abortion. However, starting any method is better than starting no method at all. This Special Report will give a short guide to available methods and when they can be started after an induced abortion.

  17. Conceptualising abortion stigma.

    Kumar, Anuradha; Hessini, Leila; Mitchell, Ellen M H

    2009-08-01

    Abortion stigma is widely acknowledged in many countries, but poorly theorised. Although media accounts often evoke abortion stigma as a universal social fact, we suggest that the social production of abortion stigma is profoundly local. Abortion stigma is neither natural nor 'essential' and relies upon power disparities and inequalities for its formation. In this paper, we identify social and political processes that favour the emergence, perpetuation and normalisation of abortion stigma. We hypothesise that abortion transgresses three cherished 'feminine' ideals: perpetual fecundity; the inevitability of motherhood; and instinctive nurturing. We offer examples of how abortion stigma is generated through popular and medical discourses, government and political structures, institutions, communities and via personal interactions. Finally, we propose a research agenda to reveal, measure and map the diverse manifestations of abortion stigma and its impact on women's health.

  18. Abortion - surgical - aftercare

    ... this page: //medlineplus.gov/ency/patientinstructions/000658.htm Abortion - surgical - aftercare To use the sharing features on ... please enable JavaScript. You have had a surgical abortion. This is a procedure that ends pregnancy by ...

  19. Effect of maternal age and miscarriage number on karyotype analysis of chorionic villus in recurrent spontaneous abortion%不同年龄和流产次数的复发性流产患者绒毛染色体核型分析

    刘玉昆; 刘梅兰; 杜涛; 陈颖; 陈慧; 张建平

    2012-01-01

    目的:了解复发性自然流产胚胎染色体异常发生情况.方法:2008年1月至2011年12月,在我院诊治并成功行绒毛染色体核型分析的自然流产患者235例,根据自然流产次数分为复发性流产组(125例)和偶发性流产组(110例).比较两组绒毛染色体异常发生率和类型的差异,不同流产次数的胚胎染色体异常发生情况,以及不同年龄患者绒毛染色体异常的发生情况.结果:复发性流产组,绒毛染色体异常发生率显著低于偶发性自然流产组(47.2% vs 70.9%,P<0.05).复发性流产组中三体占异常染色体的66.1% (39/59),显著高于偶发性流产组(44.8%,35/78)(P<0.05).随着自然流产次数的增加,绒毛染色体异常发生率降低,差异有统计学意义(x2=15.266,P=0.004).复发性流产组中,年龄≥35岁者的绒毛染色体异常发生率明显高于年龄<35岁者(60.9%vs39.2%,P<0.05).偶发性自然流产组中,年龄≥35岁者的绒毛染色体异常发生率亦明显高于年龄<35岁者(88.9%vs 62.2%,P<0.05).结论:胚胎染色体异常是引起复发性流产的一个重要原因,随着流产次数的增加,流产胚胎染色体异常的发生率降低.无论是复发性流产还是偶发性流产,高龄均是引起胚胎染色体异常的高危因素.%Objective;To investigate the chromosomal aberration in the abortus of re-current spontaneous abortion. Methods: From Jan. 2008 to Dec. 2011, chromosomal analysis was performed on products of conception of 235 pregnancies with early pregnancy loss. The frequen-cy and type of chromosomal anomalies in recurrent spontaneous abortion and sporadic abortion were compared. The frequency of embryonic chromosomal anomalies in relation to the number of miscarriage were analyesd. Results; Chromosomal abnormality rate in recurrent spontaneous a-bortion group was lower compared with sporadic abortion group (47. 2% vs 70. 9% ,P<0. 05). The frequency of trisomy in recurrent

  20. Abortion among Adolescents.

    Adler, Nancy E.; Ozer, Emily J.; Tschann, Jeanne

    2003-01-01

    Reviews the current status of abortion laws pertaining to adolescents worldwide, examining questions raised by parental consent laws in the United States and by the relevant psychological research (risk of harm from abortion, informed consent, consequences of parental involvement in the abortion decision, and current debate). Discusses issues…

  1. IL-17、RANTES及其受体在早期自然流产蜕膜组织中的表达及意义%Expression and significance of IL-17, RANTES and CCR5in decidua of first trimester spontaneous abortion

    王楠楠; 刘福民; 刘晓云

    2013-01-01

    目的 检测IL-17、T细胞激活上调性表达分泌因子S(RANTES)及其受体CCR5在正常早孕及早期自然流产患者蜕膜组织中的表达,并探讨其意义.方法 30例早期自然流产患者(流产组)和30例正常早孕妇女(对照组)的蜕膜组织,分别应用RT-PCR、ELISA方法检测蜕膜组织中IL-17、RANTES及CCR5的表达并进行线性相关分析,同时应用免疫组织化学方法染色定位其蛋白的表达.结果 ①早孕蜕膜组织中均有IL-17 mRNA、RANTES mRNA、CCR5 mRNA的表达,流产组蜕膜组织中IL-17 mRNA、RANTES mRNA、CCR5 mRNA的表达水平高于对照组,差异有统计学意义(P<0.05).②ELISA法定量检测结果与PT-PCR结果趋势一致.③IL-17与RANTES的表达呈正相关.④IL-17定位于蜕膜细胞胞质,RANTES定位于蜕膜细胞胞质及胞膜,CCR5定位于蜕膜细胞胞核.结论 早期自然流产患者蜕膜组织中IL-17、RANTES及其受体CCR5的表达水平较正常早孕者高,这种改变可能是导致早期自然流产的重要原因.%Objective To investigate the expression of interleukin - 17 (IL -17 ) ,regulated on activation normal T cell expressed and secreted (RANTES)and CCR5 in decidua of first trimester spontaneous abortion and its significance . Methods Expression of IL -17, RANTES and CCR5 in decidua of first trimester spontaneous abortion ( abortion group, n = 30) and normal first trimester pregnant women ( control group, n = 30 ) were detected by semi - quantitative RT -PCR, ELISA,and linear correlation analysis was performed . Its protein was detected by immunohistochemistry . Results ①The IL -17, RANTES and CCR5 mRNA gene expressions were detected in first trimester decidua tissues , expression of IL - 17, RANTES and CCR5 mRNA was significantly higher in abortion group compared with control group (P < 0.05 ). ②The ELISA quantitative test results were consistent with the RT - PCR results. ③Expression of IL - 17 in decidua of first trimester was positively

  2. The relationship between early pregnancy serum HCY level and serum folic acid level with unexplained spontaneous abortion%孕早期血清 HCY 及叶酸水平与原因不明自然流产的关系

    何可人; 姚吉龙; 刘庆芝; 刘芳

    2015-01-01

    Objective To discuss the relationship between early pregnancy serum homocysteine ( HCY) level and serum folic acid level with unexplained spontaneous abortion .Methods Data of 1 315 cases of early pregnant women ( gestational age≤10 weeks) accepted routine examination in Maternal and Child Health Hospital of Shenzhen City from Jan 2013 to Jan 2014 were analyzed. All cases were divided into observation group ( n=82) and control group ( n=1 233) according to whether unexplained spontaneous abortion occurred .The risk factors of unexplained spontaneous abortion were analyzed with univariate analysis and logistic regression analysis, using 10th or 90th percentile serum HCY and folic acid levels of control group as boundary values , risk of unexplained spontaneous abortion of different level groups were compared .Results Age, gravidity, history of spontaneous abortion , and low weight before pregnancy , high HCY, hyperlipidemia (OR=2.667, P<0.05) were risk factors of spontaneous abortion , taking folic acid during pregnancy, high serum folic acid level (OR=0.228, P<0.05) were protective factors.The risk of spontaneous abortion for pregnant women with low level of serum folic acid or high level of serum HCY was higher than pregnant women with normal level (OR=2.4,1.7, P<0.05).Conclusion High level of serum HCY and low level of serum folic acid in early pregnancy may result in increasing the risk of unexplained spontaneous abortion , combined detection of two indexes may help to identify high -risk pregnant women .%目的:探讨孕早期血清同型半胱氨酸(homocysteine, HCY)及叶酸水平与原因不明自然流产的关系。方法分析2013年1月至2014年1月深圳市妇幼保健院接受常规孕检的1315例孕早期(孕周≤10周)孕妇的临床资料,按是否出现原因不明自然流产,将孕妇分为观察组(82例)和对照组(1233例),采用单因素分析及多因素Logistic回归分析原因不明自然流产危险因

  3. A 1:2 Matched Case-Control Study on Risk Factors of Unexplained Recurrent Spontaneous Abortion%原因不明习惯性流产危险因素1:2病例对照研究

    王燕; 刘银梅; 戴以恒; 赵静; 袁伟; 沈月平

    2011-01-01

    Objective To investigate the environmental risk factors of unexplained recurrent spontaneous abortion.Methods A 1∶2 matched case-control study was carried out in Suzhou including 60 cases and 120 controls. Data were analyzed with univariate and multivariate conditional Logistic regression using SAS 8. 1. Results The analysis showed that main risk factors of unexplained recurrent spontaneous abortion were low level of education (OR =10.82, 95% CI:2.49 -47.04), infections of reproduotive tract (OR=3.53, 95%CI:1.44-8.62), husband alcohol drinking (OR=4.75, 95%CI:1.48-15.22), the noise exposure time more than 6 hours in current residing place (OR=5.39, 95%CI: 1.03-28.22), new furniture odor (OR=2.33, 95%CI:1.07-5.06).Passive smoking during pregnancy, the levels of noise exposure increased in current residing may be environmental risk factors of recurrent spontaneous abortion. Conclusion The study showed that the risk factors of unexplained recurrent spontaneous abortion were including low level of education, infections of reproductive tract, husband alcohol drinking, the noise exposure in current residing, new furniture odor. Passive smoking during pregnancy, the levels of noise exposure increased in current residing may be related to recurrent spontaneous abortion.%目的 探讨原因不明习惯性流产的相关环境危险因素,为预防习惯性流产提供科学依据.方法 采用流行病学1:2配比的病例-对照研究方法,对60例原因不明习惯性流产者和120例正常怀孕妇女相关流行病学资料进行了调查.应用SAS 8.1软件对调查因素进行单因素及多因素条件Logistic回归分析.结果 原因不明习惯性流产的主要危险因素是低学历(OR=10.82,95%CI:2.49~47.04)、生殖道感染(OR=3.53,95%CI:1.44~8.62)、丈夫饮酒(OR=4.75,95%CI:1.48~15.22)、现居地每日噪音暴露时间大于6h(OR=5.39,95%CI:1.03~28.22)、新家具有气味(OR=2.33,95%CI:1.07~5.06).孕期被动吸烟、居地噪

  4. High Levels of Post-Abortion Complication in a Setting Where Abortion Service Is Not Legalized

    Melese, Tadele; Habte, Dereje; Tsima, Billy M.; Mogobe, Keitshokile Dintle; Chabaesele, Kesegofetse; Rankgoane, Goabaone; Keakabetse, Tshiamo R.; Masweu, Mabole; Mokotedi, Mosidi; Motana, Mpho; Moreri-Ntshabele, Badani

    2017-01-01

    Background Maternal mortality due to abortion complications stands among the three leading causes of maternal death in Botswana where there is a restrictive abortion law. This study aimed at assessing the patterns and determinants of post-abortion complications. Methods A retrospective institution based cross-sectional study was conducted at four hospitals from January to August 2014. Data were extracted from patients’ records with regards to their socio-demographic variables, abortion complications and length of hospital stay. Descriptive statistics and bivariate analysis were employed. Result A total of 619 patients’ records were reviewed with a mean (SD) age of 27.12 (5.97) years. The majority of abortions (95.5%) were reported to be spontaneous and 3.9% of the abortions were induced by the patient. Two thirds of the patients were admitted as their first visit to the hospitals and one third were referrals from other health facilities. Two thirds of the patients were admitted as a result of incomplete abortion followed by inevitable abortion (16.8%). Offensive vaginal discharge (17.9%), tender uterus (11.3%), septic shock (3.9%) and pelvic peritonitis (2.4%) were among the physical findings recorded on admission. Clinically detectable anaemia evidenced by pallor was found to be the leading major complication in 193 (31.2%) of the cases followed by hypovolemic and septic shock 65 (10.5%). There were a total of 9 abortion related deaths with a case fatality rate of 1.5%. Self-induced abortion and delayed uterine evacuation of more than six hours were found to have significant association with post-abortion complications (p-values of 0.018 and 0.035 respectively). Conclusion Abortion related complications and deaths are high in our setting where abortion is illegal. Mechanisms need to be devised in the health facilities to evacuate the uterus in good time whenever it is indicated and to be equipped to handle the fatal complications. There is an indication for

  5. Expression of Ki-67, Bcl-2 and Bax in the First Trimester Abortion Materials

    Ender DÜZCAN

    2010-01-01

    Full Text Available Objective: The aim of this study was to investigate possible similar or different mechanisms in recurrent and spontaneous abortion by evaluating immunohistochemical correlation between proliferation marker Ki-67, and apoptosis markers Bcl-2 and Bax in the fetal trophoblasts and maternal deciduas from abortion material.Material and Method: Eighty samples of curettage materials from 65 abortion patients histopathologically diagnosed “decidua showing Arias-Stella reaction and chorionic villi” or only “decidua showing Arias-Stella reaction” were included in the study. Hematoxylin&Eosin stained sections from all cases were re-evaluated and further stained immunohistochemically using antibodies against Ki-67, Bcl-2 and Bax.Results: Proliferation rate evaluated by Ki-67 expression both in the cytotrophoblastic cells and decidua was found to be significantly lower in spontaneous and recurrent abortions compared to evacuation abortion. The extent of Bcl-2 expression in syncytiotrophoblastic cells covering villous stroma was also decreased in spontaneous abortion. There were no significant differences between spontaneous and recurrent abortions in terms of Bcl-2 expression in syncytiotrophoblasts and Ki-67 proliferation index in cytotrophoblastic cells or decidua. Bax staining showed minimal decidual expression in a few spontaneous and recurrent abortions.Conclusion: We concluded that proliferation rate was decreased in fetal villous cytotrophoblasts and maternal deciduas in spontaneous and recurrent abortions. We also proposed that loss of Bcl-2 expression in syncytiotrophoblasts may cause abortion in a subset of cases. However, the data from spontaneous and recurrent abortions did not not support the presence of different mechanisms in both groups.

  6. STUDY OF IMMUNOTHERAPY WITH LYMPHOCYTES IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION%淋巴细胞主动免疫治疗复发性流产的疗效研究

    崔艳萍; 钟小烨; 班清媚; 胡克; 肖淑君

    2011-01-01

    [Objective] To investigate the curative effect of immunotherapy with lymphocytes in women with recurrent spontaneous abortion. [Methods] 100 patients diagnosed as RSA caused by lacking blocking antibodies were divided into two groups: 50 cases as group of immunotherapy (control group) , another 50 cases with no therapy (comparison group). [Resuits] In control group and comparison group, the success rates of pregnancy were 82.00% (41/50) and 48.00% (24/50) respectively. There was a significant difference for the rate of pregnancy between these two groups (P < 0.05). After immunotherapy, in positive-blocking antibodies group and negative-blocking antibodies group, the success rates of pregnancy were 88.24% (30/34) and 56.25% (9/16) respectively. There was a significant difference for the rate of pregnancy between these two groups (P < 0.05). [Conclusion] Immunotherapy with lymphocytes in women with RSA caused by lacking blocking antibodies may increase pregnancy rate and have credible curative effect and application value.%[目的]探讨淋巴细胞主动免疫治疗复发性流产的疗效研究.[方法]将临床筛查确诊为封闭抗体缺乏所致的复发性流产患者100例随机分为2组,研究组50例,采用淋巴细胞主动免疫治疗;对照组50例,未行任何处理.比较两组妊娠结局.研究组治疗后常规复查封闭抗体,比较封闭抗体阳性组及阴性组妊娠结局.[结果]研究组及对照组妊娠成功率分别为82.00%(41/50)及48.00%(24/50),两组比较差异有统计学意义(P<0.05);免疫治疗后,封闭抗体阳性组及阴性组妊娠成功率分别为88.24%(30/34)及56.25%(9/16),两组比较差异有统计学意义(P<0.05).[结论]淋巴细胞主动免疫治疗封闭抗体缺乏所致复发性流产可显著提高妊娠成功率,有较可靠的临床效果及应用价值.

  7. 阿司匹林联合泼尼松治疗复发性流产效果观察%Aspirin combined with prednisone for treatment of recurrent spontaneous abortion

    张静; 张宁芝

    2013-01-01

    目的:观察小剂量阿司匹林联合泼尼松治疗复发性流产(RSA)的疗效.方法:将53例RSA的患者随机分为治疗组33例和对照组20例.治疗组每天予以阿司匹林100 mg、泼尼松5 mg 1次口服,共3个月;3个月后阿司匹林减量至25 mg,泼尼松减量至2.5 mg,每晚1次口服,直至妊娠后3个月.对照组常规黄体酮等保胎药物治疗.将生育活婴或者妊娠28周内未出现胎儿异常视为妊娠有效,比较2组治疗有效率、活产率及妊娠合并症发生率.结果:治疗组患者治疗有效率明显高于对照组(P<0.01),且妊娠期使用小剂量阿司匹林及泼尼松并不增加妊娠合并症的发生.结论:小剂量阿司匹林联合泼尼松能有效改善RSA的妊娠结局,具有临床可行性.%Objective:To invesligale the efficacy of low dose of prednisone combined with aspirin on recurrent spontaneous abortion (RSA). Methods:Fifty-three cases of RSA were randomly divided into treatment group(33 cases) and conlrol group(20 cases). The cases in the treatment group were administered low dose of prednisone 100 mg once each day and aspirin 5 mg once every night for 3 months;3 months later, the dosage of aspirin was decreased Lo 25 mg and prednisone Lo 2. 5 mg once every night. The therapy was carried out until 3 months after pregnancy; the controls were given the routine therapy of progeslerone only. The therapy was regarded as effective when the fetal in utero was alive or presenling no fetal disorder at 28 weeks of geslation. The treatment efficacy, the live birth rale and the incidence of pregnancy-coexisled diseases were compared belween the two groups. Results:The efficacy rale in the treatment group was significantly higher than that in the conlrol(P <0. 01) and low dose of aspirin and prednisone woutd not increase the incidence of pregnancy-coexisled diseases. Conclusions:The therapy of low dose of prednisone combined with aspirin can effectively prevenl the incidence of RSA and is highly

  8. Abnormal expression of Tim -3 in unexplained recurrent spontaneous abortion%Tim-3分子表达异常与原因不明复发性流产的关系

    张铭; 肖嘉伟; 刘文惠; 周春; 张元珍

    2012-01-01

    目的 探究T细胞免疫球蛋白粘蛋白分子3(Tim -3)表达异常与不明原因复发性流产(URSA)的关系.方法 选择31例URSA患者作为研究组,并以同期30例正常孕妇作为对照组.采用流式细胞术检测两组外周血单个核细胞( PBMC)中CD4+ Tim -3+细胞/CD4+细胞的比例,Western Blot技术检测蜕膜中Tim -3蛋白的相对含量,并以免疫磁珠法分选CD4+ Tim -3+细胞,荧光定量RT - PCR检测两组外周血PBMC、CD4+ Tim -3+细胞及蜕膜组织中Tim -3 mRNA的表达.结果 URSA组中,PBMC中CD4+ Tim -3+细胞/CD4+细胞为5.23±0.96%,蜕膜中Tim -3蛋白的相对表达量为0.64±0.09,PBMC及蜕膜中Tim -3 mRNA的相对表达量为0.65±0.09及0.50±0.07,均显著高于正常对照组(P<0.01).但是,URSA组CD4+ Tim -3+细胞(Th1 细胞)Tim -3 mRNA的表达量低于正常对照组,差异具有显著性(P<0.01).结论 Th1细胞Tim -3表达降低,Th1细胞过度活化可能参与了URSA的发生发展过程.%Objective; To explore the relationship between abnormal expression of T cell immunoglobulin - and mucin - domain containing molecular-3 (Tim-3) and unexplained recurrent spontaneous abortion (URSA). Methods; 31 pregnant women suffered with URSA were recruited as the study group and 30 normal pregnant women were chosen as the control group. For the two groups, CD4 + Tim - 3 + cells/CD4 + cell percentage in peripheral blood mononuclear ( PBMC) were detected by flow cytometry. Then CD4 + Tim - 3 + cells were collected by magnetic activated cell sorting. The expression levels of Tim - 3 mRNA in PBMC, CD4 + Tim - 3 + cells and decidua were detected by fluorescent quantitative RT - PCR. Besides, the relative amount of Tim - 3 protein was also analyzed u-sing Western blot. Results: In URSA group, the CD4 + Tim - 3 + cells/CD4 + cell percentage in PBMC was 5. 23 ± 0. 96% , the relative level of Tim - 3 protein in decidua was 0.64 ± 0. 09, the relative amounts of Tim - 3 mRNA in PBMC and decidua were 0. 65 ± 0

  9. Abortion: the continuing controversy.

    Behrens, C E

    1972-08-01

    While most countries of the world practice abortion, government policy, medical opinion, private opinion and actual practice vary widely. Although mortality from legal abortions is quite low, complications rise sharply after 12 gestational weeks. No conclusive proof shows adverse postabortion psychological effects. Romania, Japan and the Soviet Union experienced declining birth rates when abortion was made available and New York City saw a decline in illegitimacy of approximately 12% from 1970 to 1971. Throughout the world abortion laws vary from restrictive to moderate to permissive. Where laws are restrictive, as in France and Latin America, illegal abortions are estimated in the millions. The controversy over abortion centers around the arguments of what constitutes a human life, and the rights of the fetus versus the right of a woman to control her reproductive life. A review of state abortion laws as of August 1972 shows pressure on state legislatures to change existing laws. The future of abortion depends upon technological advances in fertility control, development of substitutes like menstral extraction, prostaglandins and reversible sterilization. Development of these techniques will take time. At present only through education and improved delivery of contraceptives can dependence on abortion as a method of fertility control be eased. Citizen education in the United States, both sex education and education for responsbile parenthood, is in a poor state according to the Commission on Population Growth and the American Future. If recourse to abortion is to be moderated, it is the next generation of parents who will have to be educated.

  10. 精液优化处理后DNA碎片指数、精子畸形率与IVF胚胎发育、早期自然流产的相关性%Correlation of the DNA fragmentation index and malformation rate of optimized sperm with embryonic development and early spontaneous abortion in IVF-ET

    江伟杰; 金帆; 周黎明

    2016-01-01

    Objective:To investigate the effects of the DNA fragmentation index (DFI) and malformation rate (SMR) of optimized sperm on embryonic development and early spontaneous abortion in conventional in vitro fertilization and embryo transfer (IVFET).Methods:We selected 602 cycles of conventional IVF-ET for pure oviductal infertility that had achieved clinical pregnancies,including 505 cycles with ongoing pregnancy and 97 cycles with early spontaneous abortion.On the day of ovum retrieval,we examined the DNA integrity and morphology of the rest of the optimized sperm using the SCD and Diff-Quik methods,established the joint predictor (JP) by logistic equation,and assessed the value of DFI and SMR in predicting early spontaneous abortion using the ROC curve.Results:The DFI,SMR,and high-quality embryo rate were (15.91 ± 3.69) %,(82.85 ± 10.24) %,and 46.53% (342/735) in the early spontaneous abortion group and (9.30 ± 4.22)%,(77.32 ± 9.19)%,and 56.43% (2263/4010) respectively in the ongoing pregnancy group,all with statistically significant differences between the two groups (P < 0.05).Both the DFI and SMR were the risk factors of early spontaneous abortion (OR =5.96 and 1.66;both P < 0.01).The areas under the ROC curve for DFI,SMR and JP were 0.893 ± 0.019,0.685 ± 0.028,and 0.898 + 0.018,respectively.According to the Youden index,the optimal cut-off values of the DFI and SMR obtained for the prediction of early spontaneous abortion were approximately 15% and 80%.The DFI was correlated positively with SMR (r =0.31,P < 0.01) but the high-quality embryo rate negatively with both the DFI (r =-0.45,P < 0.01)and SMR (r =-0.22,P < 0.01).Conclusion:The DFI and SMR of optimized sperm are closely associated with embryonic development in IVF.The DFI has a certain value for predicting early spontaneous abortion with a threshold of approximately 15%,but SMR may have a lower predictive value.%目的:探讨精液优化处理后DNA碎片指数(DFI)、精

  11. Ethical and Juridical Relativism of Abortion in Embryo Reduction

    2012-01-01

    Ethics is the science of human behavior in society. Ethical discussions are daily inserted within a new social dimension, such as abortion and embryo reduction. Abortion is the interruption of pregnancy spontaneously or intentionally, resulting in the death of the still-to-be-born child. The Brazilian Federal Constitution and Civil Law guarantee the right to life from conception and provides the right of personality to the born child. However, the juridical ordering does not pinpoint the time...

  12. Effect of folic acid intervention on homocysteine and folic acid levels for patients with recurrent spontaneous abortion%叶酸干预对复发性流产患者同型半胱氨酸及叶酸水平的影响探讨

    李玲; 余发琼; 廖蓉

    2016-01-01

    目的:探讨叶酸干预对复发性流产患者同型半胱氨酸(HCY)及叶酸水平的影响。方法以42例复发性流产患者为研究对象,45例正常孕前检查者为对照,检测2组血清HCY水平、叶酸水平,根据检查结果给予叶酸干预,比较干预后2组HCY、叶酸水平。结果入组时复发性流产组血清HCY、血浆叶酸及红细胞叶酸水平与对照组比较差异均有统计学意义(P0.05)。结论复发性流产患者血清同型半胱氨酸水平高于正常女性,叶酸水平偏低,叶酸干预可改善患者叶酸代谢紊乱、降低同型半胱氨酸水平。%Objective To investigate the effect of folic acid intervention on homocysteine(HCY) and folate levels for patients with recurrent spontaneous abortion (RPA). Methods Made 42 cases of patients with recurrent spontaneous abortion as the research object and 45 cases of normal pregnancy examination women as control , serum Hcy level, folate levels of two groups were detected, according to the results of the examination give folic acid, Hcy, folate levels after intervention were compared. Results The level of serum HCY, plasma folate and red cell folate levels in RPA group at baseline were significant differences from control group (P0.05). Conclusion Serum HCY level in patients with recurrent spontaneous abortion is higher than that of normal women, and the level of folic acid is low, the intervention of folic acid can improve the metabolic disorders and reduce the level of HCY.

  13. 普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产疗效的Meta分析%Meta analysis of the efficacy of common heparin and low molecular heparin in the treatment of anti phospholipid antibody positive recurrent spontaneous abortion

    杨晶晶; 刘帅斌; 胡丽娜

    2015-01-01

    目的:探讨普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产的疗效。方法:采用Cochrane协作网系统评价方法,对有关普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产研究进行质量评价。结果:低分子肝素组的胎儿流产风险是普通肝素组的0.59倍;低分子肝素组治疗复发性流产妇女最终导致其并发症的发生风险是普通肝素组的1.34倍,但差异均无统计学意义(P>0.05)。结论:普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产的临床疗效无差异。%Objective:To investigate the efficacy of common heparin and low molecular heparin in the treatment of anti phospholipid antibody positive recurrent spontaneous abortion.Methods:We adopted the cochrane cooperative network system evaluation method,to do the quality evaluation of the common heparin and low molecular heparin in the treatment of anti phospholipid antibody positive recurrent spontaneous abortion.Results:Low molecular heparin group fetal risk of miscarriage is unfractionated heparin group 0.59 times;low molecular weight heparin group treatment of women with recurrent spontaneous abortion ultimately lead to the complication risk is unfractionated heparin group of 1.34 times,but the difference was not statistically significant (P>0.05).Conclusion:There is no difference between the clinical efficacy of ordinary heparin and low molecular heparin in the treatment of anti phospholipid antibody positive recurrent miscarriage.

  14. [Bioethics and abortion. Debate].

    Diniz, D; Gonzalez Velez, A C

    1998-06-01

    Although abortion has been the most debated of all issues analyzed in bioethics, no moral consensus has been achieved. The problem of abortion exemplifies the difficulty of establishing social dialogue in the face of distinct moral positions, and of creating an independent academic discussion based on writings that are passionately argumentative. The greatest difficulty posed by the abortion literature is to identify consistent philosophical and scientific arguments amid the rhetorical manipulation. A few illustrative texts were selected to characterize the contemporary debate. The terms used to describe abortion are full of moral meaning and must be analyzed for their underlying assumptions. Of the four main types of abortion, only 'eugenic abortion', as exemplified by the Nazis, does not consider the wishes of the woman or couple--a fundamental difference for most bioethicists. The terms 'selective abortion' and 'therapeutic abortion' are often confused, and selective abortion is often called eugenic abortion by opponents. The terms used to describe abortion practitioners, abortion opponents, and the 'product' are also of interest in determining the style of the article. The video entitled "The Silent Scream" was a classic example of violent and seductive rhetoric. Its type of discourse, freely mixing scientific arguments and moral beliefs, hinders analysis. Within writings about abortion three extreme positions may be identified: heteronomy (the belief that life is a gift that does not belong to one) versus reproductive autonomy; sanctity of life versus tangibility of life; and abortion as a crime versus abortion as morally neutral. Most individuals show an inconsistent array of beliefs, and few groups or individuals identify with the extreme positions. The principal argument of proponents of legalization is respect for the reproductive autonomy of the woman or couple based on the principle of individual liberty, while heteronomy is the main principle of

  15. Spontaneous Pregnancy Loss in Denmark Following Economic Downturns

    Bruckner, Tim A.; Mortensen, Laust H.; Catalano, Ralph A.

    2016-01-01

    by 1 month a rise in the number of spontaneous abortions (β = 33.19 losses/month, 95% confidence interval: 8.71, 57.67). An attendant analysis that used consumption of durable household goods as an indicator of financial insecurity supported the inference from our main test. Changes over time......An estimated 11%–20% of clinically recognized pregnancies result in spontaneous abortion. The literature finds elevated risk of spontaneous abortion among women who report adverse financial life events. This work suggests that, at the population level, national economic decline—an ambient...

  16. 血清可溶性肿瘤坏死因子受体Ⅰ、Ⅱ与早期自然流产临床关系的研究%Study of the relation between the level of soluble tumor necrosis factor receptor I, Ⅱ in serum and the early spontaneous abortion

    孙阳; 赵轩; 杨敏; 刘碧芬; 敖竹君

    2002-01-01

    目的研究早期自然流产妇女血清中可溶性肿瘤坏死因子受体(sTNFR)Ⅰ和Ⅱ的水平.方法应用双抗体夹心ABC-ELISA法检测孕3月内20例正常妊娠、20例第一次自然流产(spon-taneous abortion,15)和15例反复自然流产(recurrent spontaneous abortion,BSA)妇女血清中的sTNFRⅠ与sTNFRⅡ.结果SA与对照组比较,sTNFRⅠ显著增高(P<0.05);sTNFRⅠ与sTNFRⅡ在RSA中的水平较SA均有显著增高(P<0.01).结论sTNFR可能与自然流产的发生发展有关.其水平(尤其是sTN-FRⅠ)的升高就妊娠而言可能具有自我保护和自我稳定的生理意义.

  17. 首次发生自然流产的高龄妇女病因筛查及治疗效果评价%Etiological screening of first spontaneous abortion in women over 35 years of age and therapy evaluation

    王哲蔚; 朱盈; 李芬; 俞铮

    2016-01-01

    目的 研究首次发生自然流产的≥35周岁妇女的病因筛查及治疗效果.方法 172名在近3个月内首次发生自然流产的≥35周岁患者,经知情同意将其中要求根据复发性流产检查指南进行病因筛查的82名患者作为干预组,进行病因筛查并根据筛查结果进行治疗,另90名不愿行病因筛查的患者作为对照组,随访两组1年之内的受孕结局.结果 干预组中,筛查阳性率为60.98%,被筛查出2种及以上病因的占20.73%,其中"可疑血栓前状态"的筛查阳性率最高,为45.12%;其次为"卵巢功能减退"(15.85%)及免疫原因(10.98%).干预组1年内自然受孕率为37.50%,显著高于对照组的21.18%(χ2=5.323,P=0.021),且再次妊娠后孕早期流产率(26.67%)显著低于对照组(72.22%),χ2=9.487,P=0.002.结论 对首次发生自然流产的高龄妇女实施病因筛查和治疗有利于改善再次受孕不良结局.%Objective To study the etiological screening of spontaneous abortion for the first time in women over 35 years of age and therapeutic effect.Methods Totally 172 women over 35 years of age who had only spontaneous abortion in the past 3 months were selected as subjects.Among them, 82 subjects who actively requesting etiological screening were included into intervention group and therapy were given aiming at etiology, whereas the other 90 women who refused etiological screening were recruited into control group.The conception outcomes within 1 year of all subjects in two groups were followed up.Results In the intervention group, the positive rate of screening was 60.98%and 20.73% of the women were detected to have no less than 2 types of etiology.The screening positive rate of suspected prethrombotic state was highest (45.12%), followed by positive rate of ovarian dysfunction and immune abnormalities (15.85%, 10.98%).In the intervention group the nature conception rate within 1 year was 37.50%, which was significantly higher than that in the control

  18. The investigation of the relationship between hyperthyroidism with recurrent spontaneous abortion%甲状腺功能亢进症与复发性自然流产关系的初步探讨

    路鸿艳

    2011-01-01

    Objective: To investigate the relationship between hyperthyroidism including subclinical hyperthyroidism withrecurrent spontaneous abortion (RSA). Methods: 66 cases of RSA women (RSA group) and 99 cases of non-pregnancywomen (control group) were enrolled in the study. Serum free T3 (FT3), free T4 (FT4) and thyrotropin (TSH) were measuredby immune radiate method. Results: There were 16 cases with a hyperthyroidism in RSA group, the overall prevalence ofhyperthyroidism was 24.24%; there were 9 cases with hyperthyroidism in the control group, the overall prevalence ofhyperthyroidism was 9.09%, RSA group of hyperthyroidism prevalence rate was higher than that of the control group, thedifference was statistically significant (x2=7.07, P<0.01). RSA group and control group were compared in subclinicalhypeithyroidism, there was a significant difference (x2=4.80, P<0.05). In RSA group the prevalence of subclinicalhyperthyroidism was higher than that of clinical hyperthyroidism, there was a significant difference (18.18% vs 6.06%, x2=4.55, P<0.05). In RSA group the free T4 was at an average of (18.96±5.58) μIU/ml, the control group (17.10±3.99) μU/ml,there was a significant difference (t=2.43, P<0.05). Conclusion: RSA group, hyperthyroidism including subclinicalhyperthyroidism prevalence is significantly higher, in patients with hyperthyroidism occurred with its own RSA have acertain correlation. It is possible one of the reasons that the abnormal FT4 or TSH leaded to RSA.%目的:探讨甲状腺功能亢进症包括亚临床甲状腺功能亢进症与复发性自然流产的关系.方法:选择66例有复发性自然流产史的妇女为研究组(复发性自然流产组),99例健康未孕妇女为对照组.应用免疫放射方法检测FT3、FT4、TSH.结果:复发性自然流产组甲亢患者有16例,甲亢患病率为24.24%;对照组甲亢患者有9例,甲亢患病率为9.09%,复发性自然流产组甲亢患病率显著高于对照组,

  19. Changes in the determinants of induced abortion in Korea.

    Cho, N H; Ahn, N

    1993-12-01

    Study results suggested that Korea's family planning program must shift to the promotion of a balanced sex ratio and prevention of induced abortion. The abortion rate increased markedly until the mid-1980s and then stabilized. The number of abortions almost equalled the number of live births. Retrospective data from the 1991 National Fertility and Family Health Survey of Korea were used to examine the determinants of pregnancy outcomes. The sample included 8475 pregnancies at parity 0, 7947 at parity 1, 5358 at parity 2, and 3437 at parity 3 or higher. An interesting finding was that families with 2 girls reported a very high number of spontaneous abortions since 1985: over 10% (41/389). The number of spontaneous abortions among families with 1-2 male children was only 3% (22/718). Among childless parents only 27% of pregnancies were aborted, while among one-child families 46% were aborted and among two-child families 81% were aborted. From before 1975 until after 1985, abortions among childless parents increased from 10% to 30%. This increase was accounted for by the increased number of premarital pregnancies, which were greater among middle and high school graduates. The abortion rate was high for pregnancies occurring at least 8 months before marriage and for pregnancies of more highly educated recent cohorts occurring earlier than 7 months before marriage. The probability of abortion was 3% for cohorts prior to 1974 with one son and 9% for the recent cohort (1985 and later). This shift may reflect a changed preference for smaller families and son preference. About 40% of pregnancies resulted in a live birth among families with 2 daughters in the most recent cohort. The probability of abortion was 33% higher among families with 2 boys in the earliest cohort than families without a son. The effect of education on pregnancy outcome varied with parity and time period. The abortion rate was higher among educated women, which meant less effective contraceptive

  20. Abortion in Adolescence.

    Campbell, Nancy B.; And Others

    1988-01-01

    Explored differences between 35 women who had abortions as teenagers and 36 women who had abortions as adults. Respondents reported on their premorbid psychiatric histories, the decision-making process itself, and postabortion distress symptoms. Antisocial and paranoid personality disorders, drug abuse, and psychotic delusions were significantly…

  1. Effects of abortion legalization in Nepal, 2001-2010.

    Jillian T Henderson

    Full Text Available BACKGROUND: Abortion was legalized in Nepal in 2002, following advocacy efforts highlighting high maternal mortality from unsafe abortion. We sought to assess whether legalization led to reductions in the most serious maternal health consequences of unsafe abortion. METHODS: We conducted retrospective medical chart review of all gynecological cases presenting at four large public referral hospitals in Nepal. For the years 2001-2010, all cases of spontaneous and induced abortion complications were identified, abstracted, and coded to classify cases of serious infection, injury, and systemic complications. We used segmented Poisson and ordinary logistic regression to test for trend and risks of serious complications for three time periods: before implementation (2001-2003, early implementation (2004-2006, and later implementation (2007-2010. RESULTS: 23,493 cases of abortion complications were identified. A significant downward trend in the proportion of serious infection, injury, and systemic complications was observed for the later implementation period, along with a decline in the risk of serious complications (OR 0.7, 95% CI 0.64, 0.85. Reductions in sepsis occurred sooner, during early implementation (OR 0.6, 95% CI 0.47, 0.75. CONCLUSION: Over the study period, health care use and the population of reproductive aged women increased. Total fertility also declined by nearly half, despite relatively low contraceptive prevalence. Greater numbers of women likely obtained abortions and sought hospital care for complications following legalization, yet we observed a significant decline in the rate of serious abortion morbidity. The liberalization of abortion policy in Nepal has benefited women's health, and likely contributes to falling maternal mortality in the country. The steepest decline was observed after expansion of the safe abortion program to include midlevel providers, second trimester training, and medication abortion, highlighting the

  2. Abortion in adolescence.

    Greydanus, D E; Railsback, L D

    1985-09-01

    This article reviews the difficult but complex subject of abortion in adolescents. Methods of abortion are outlined and additional aspects are presented: psychological effects, counseling issues, and legal parameters. It is our conclusion that intense efforts should be aimed at education of youth about sexuality and prevention of pregnancy, utilizing appropriate contraceptive services. When confronted with a youth having an unwanted pregnancy, all legal options need to be carefully explored: delivery, adoption, or abortion. The decision belongs to the youth and important individuals in her environment. Understanding developmental aspects of adolescence will help the clinician deal with the pregnant teenagers. If abortion is selected, a first trimester procedure is best. Finally, physicians are urged to be aware of the specific, ever changing legal dynamics concerning this subject which are present in their states. Abortion is a phenomenon which has become an emotional but undeniably important aspect of adolescent sexuality and adolescent health care, in this country and around the world.

  3. Dydrogesterone combined with psychological intervention on research of recurrent spontaneous abortion pregnancy outcome influence%地屈孕酮联合心理干预对复发性流产患者妊娠结局影响的研究

    朱莉; 刘琴; 刘玉芳; 席予凡

    2014-01-01

    目的:了解地屈孕酮联合心理干预对复发性流产患者妊娠结局的影响。方法:将157例患者随机分为心理干预组79例和对照组78例。心理干预组采用口服地屈孕酮及心理健康疏导,对照组采用口服地屈孕酮及常规指导,观察治疗前后SAS、SDS评分以及妊娠结局。结果:在口服地屈孕酮后通过心理疏导解除患者焦虑、抑郁心理,心理干预组的SAS、SDS评分组明显低于治疗前及对照组的评分,其最终妊娠结局也有明显改善。结论:反复流产对患者在心理上造成很明显焦虑及恐惧,通过药物及心理疏导可以提高复发性流产患者的妊娠结局。%Objective:Understanding of dydrogesterone combined with psychological intervention on influence of recurrent spontaneous abortion pregnancy outcome.Method:157 patients were randomly divided into the psychological intervention group with 79 cases and the control group with 78 cases.The psychological intervention group used dydrogesterone orally and mental health counseling.The control group used dydrogesterone orally and conventional guidance.We observed the score of SAS and SDS before and after treatment and the pregnancy outcome.Results:We relieved the anxiety and depression of the patients by psychological counseling after they had progesterone.The score of the group of psychological intervention group was obviously lower than the control group before treatment,and its final pregnancy outcomes have improved significantly.Conclusion:Recurrent abortion can cause obvious anxiety of the patients and fear psychological,and we can improve the outcome of pregnancy in women with recurrent spontaneous abortion by the drug and psychological counseling.

  4. Analysis on the levels of vitamin A and vitamin E in human villi tissue and risk factors of spontaneous abortion%自然流产者绒毛织中维生素A、E含量及流产影响因素分析

    吴思萍; 康阳; 马静; 卞华伟; 高永清

    2012-01-01

    目的 了解孕早期妇女的自然流产状况与维生素A、E营养状况的关系,为指导孕妇健康膳食提供科学依据.方法 于2010年10月~2011年4月在广州市收集进行流产刮宫术的孕妇绒毛组织共258例(自然流产组63例,对照组195例).对研究对象进行问卷调查及24h膳食调查,并采用高效液相色谱法检测绒毛组织中的维生素A、E含量.结果 自然流产组与对照组的比较中,年龄、体质指数、婚姻状况、流产史、孕周的差异均具有统计学意义(均有P<0.05);多因素Logistic回归分析显示,自然流产的危险因素为年龄(与≤22岁相比,23~岁组:OR=3.903,95%CI:1.533~9.937;≥29岁组:OR=2.896,95%CI:1.116 ~7.519)、流产史(OR=2.174,95% CI:1.105 ~4.278)和孕周≥8周(OR=3.532,95%CI:1.813 ~6.883).自然流产组能量、蛋白质、脂肪、碳水化合物、维生素A、维生素E的摄入量与对照组比较,差异也无统计学意义.自然流产组绒毛组织中维生素A、E含量与对照组的比较,差异均无统计学意义(均有P>0.05).结论 年龄、流产史是自然流产的危险因素;未见自然流产者膳食维生素A、E摄入量及绒毛组织中维生素A、E含量增加.%Objective To assess the relationship between dietary factors and risk factors of spontaneous abortion in women. Methods Study population included 258 cases of early pregnancy (63 cases who had spontaneous abortion and 195 normal pregnancy who had elective abortion as a control group) during Oct 2010 to Apr 2011 at Guangzhou, and 24 h dietary recall and the questionnaire survey were used to evaluate the diet and other factors. The levels of vitamin A and vitamin E in villi tissue of subjects were measured by high performance liquid phase chromatography (HPLC) . Results The age (23-, OR = 3.903, 95% Cl; 1. 533-9. 937; Ss29, OR = 2.896, 95% CI: 1. 116-7. 519) , gestational age≥8 weeks (Ofl = 3.532, 95% CI: 1.813-6. 883) and abortion

  5. 辅助生殖技术治疗后孕早期自然流产的绒毛细胞染色体分析%Chromosomal Analysis in Spontaneous Abortion during the First Trimester after Assisted Reproduction Technique Treatment

    李跃萍; 徐雯; 黎明红; 麦扬青; 陈竞茜; 闫庆峰

    2011-01-01

    Objective To know about chromosome abnormalities in spontaneous abortion during the first trimester after assisted reproduction technique treatment and to provide some data for eugenics. Methods A retrospective analysis was performed on 41 clinical spontaneous abortion cases during the first trimester following ART, which including in vitro fertilization-embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI) and frozen embryo transfer (F-ET) and intrauterine insemination (IUI). Cytogenetic analysis of the chorionic villi by cell culture and standard G-banding cytogenetic techniques was performed. Results Successful analysis was conducted in 30 specimens. Fifteen of 30 specimens had a chromosomal abnormality,accounting for 50%. The majorities were numerical abnormalities such as monosomy X (one case). Trisomies for chromosomes 11 cases, including 18 trisomies in one case, 16 trisomies in three cases, 15 trisomies in two case, 4 trisomies in one cases, 9 trisomies in one case, 2 trisomies in one case, mosaic trisomy 21 trisomies in two cases, and polyploidin one case were observed. 46, XX/47, XX, +mar karyotype was observed in one case. Conclusions ART abortion is closely related with embryo chromosome abnormalities. Aneuploidy is the major factor affecting embryonic development in spontaneous abortions during the first trimester after ART.%目的 了解辅助生殖技术(ART)治疗后孕早期自然流产的绒毛细胞染色体的异常情况,为优生优育工作作指导.方法 选择行体外受精-胚胎移植(IVF-ET)、单精子卵胞浆内显微注射( ICSI)、冻融胚胎移植(F-ET)及宫腔内人工授精(IUI)治疗后的自然流产绒毛标本41例,进行绒毛细胞培养及G显带,分析染色体核型.结果 41例标本中有30例培养成功,绒毛染色体异常15例,占50%.多数为数目异常,其中X单体1例,染色体三体11例(包括18三体1例,16三体3例,15三体2例,4号三体1例,9号三体1例,2号三体1

  6. Rewriting abortion: deploying medical records in jurisdictional negotiation over a forbidden practice in Senegal.

    Suh, Siri

    2014-05-01

    Boundary work refers to the strategies deployed by professionals in the arenas of the public, the law and the workplace to define and defend jurisdictional authority. Little attention has been directed to the role of documents in negotiating professional claims. While boundary work over induced abortion has been extensively documented, few studies have examined jurisdictional disputes over the treatment of abortion complications, or post-abortion care (PAC). This study explores how medical providers deploy medical records in boundary work over the treatment of complications of spontaneous and induced abortion in Senegal, where induced abortion is prohibited under any circumstance. Findings are based on an institutional ethnography of Senegal's national PAC program over a period of 13 months between 2010 and 2011. Data collection methods included in-depth interviews with 36 health care professionals, observation of PAC services at three hospitals, a review of abortion records at each hospital, and a case review of illegal abortions prosecuted by the state. Findings show that health providers produce a particular account of the type of abortion treated through a series of practices such as the patient interview and the clinical exam. Providers obscure induced abortion in medical documents in three ways: the use of terminology that does not differentiate between induced and spontaneous abortion in PAC registers, the omission of data on the type of abortion altogether in PAC registers, and reporting the total number but not the type of abortions treated in hospital data transmitted to state health authorities. The obscuration of suspected induced abortion in the record permits providers to circumvent police inquiry at the hospital. PAC has been implemented in approximately 50 countries worldwide. This study demonstrates the need for additional research on how medical professionals negotiate conflicting medical and legal obligations in the daily practice of treating

  7. Costs and consequences of abortions to women and their households: a cross-sectional study in Ouagadougou, Burkina Faso.

    Ilboudo, Patrick G C; Greco, Giulia; Sundby, Johanne; Torsvik, Gaute

    2015-05-01

    Little is known about the costs and consequences of abortions to women and their households. Our aim was to study both costs and consequences of induced and spontaneous abortions and complications. We carried out a cross-sectional study between February and September 2012 in Ouagadougou, the capital city of Burkina Faso. Quantitative data of 305 women whose pregnancy ended with either an induced or a spontaneous abortion were prospectively collected on sociodemographic, asset ownership, medical and health expenditures including pre-referral costs following the patient's perspective. Descriptive analysis and regression analysis of costs were performed. We found that women with induced abortion were often single or never married, younger, more educated and had earlier pregnancies than women with spontaneous abortion. They also tended to be more often under parents' guardianship compared with women with spontaneous abortion. Women with induced abortion paid much more money to obtain abortion and treatment of the resulting complications compared with women with spontaneous abortion: US$89 (44 252 CFA ie franc of the African Financial Community) vs US$56 (27 668 CFA). The results also suggested that payments associated with induced abortion were catastrophic as they consumed 15% of the gross domestic product per capita. Additionally, 11-16% of total households appeared to have resorted to coping strategies in order to face costs. Both induced and spontaneous abortions may incur high expenses with short-term economic repercussions on households' poverty. Actions are needed in order to reduce the financial burden of abortion costs and promote an effective use of contraceptives.

  8. Analysis on infection of bacterial vaginosis and ureaplasma urealyticum with 118 recurrent spontaneous abortion women%反复性自然流产患者细菌性阴道病及解脲支原体感染状况118例分析

    刘菲; 纪巍

    2011-01-01

    目的 了解反复性自然流产患者下生殖道细菌性阴道病及解脲支原体感染情况.方法 对118例反复性自然流产患者作为实验组及109例有正常妊娠史的健康体检者作为对照组, 进行下生殖道细菌性阴道病及解脲支原体感染检测.结果实验组细菌性阴道病感染28例(23.7%),解脲支原体感染49例(41.5%),二者双重感染25例(21.2%);对照组细菌性阴道病感染13例 (11.0%),解脲支原体感染22例(20.2%),二者双重感染9 例(8.3%),实验组与对照组比较有统计学意义(P<0.05).自然流产2次患者细菌性阴道病感染16例(21.0%),解脲支原体感染28例(36.8%), 二者双重感染15例(19.7%).自然流产≥3次患者细菌性阴道病感染13例(28.6%),解脲支原体感染21例(50.0%),二者双重感染10例(23.8%).随着流产次数的增加解脲支原体感染率上升(P<0.05),细菌性阴道病及二者双重感染率也呈上升趋势,但无统计学意义(P>0.05).结论 下生殖道细菌性阴道病及解脲支原体感染与反复性自然流产之间存在一定相关性,孕前检查要重视筛查细菌性阴道病及解脲支原体感染情况.%Objective To study the reproductive tract in patients with recurrent abortion, bacterial vaginosis and ureaplasm urealyticum infection. Methods Collected in June 2006 ~ October 2009 in our hospital prenatal and postnatal care center treatment of 118 cases of patients with recurrent spontaneous abortion as an object of study, a history of normal pregnancy, 109 cases of healthy persons as control the crowd, the next reproductive tract bacteria vaginal disease and detection of ureaplasma urealyticum infection.Results Experimental group of bacterial vaginosis infection in 28 cases ( 23.7% ), ureaplasma urealyticum infection in 49 cases ( 41.5% ), both co-infection 25 ( 21.2% ); control group, bacterial vaginosis infection in 13 cases ( 11.0% ), ureaplasma urealyticum infection in 22 cases ( 20.2% ), both

  9. Abortion and Selection

    2006-01-01

    The introduction of legalized abortion in the early 1970s led to dramatic changes in fertility behavior. Some research has suggested as well that there were important impacts on cohort outcomes, but this literature has been limited and controversial. In this paper, we provide a framework for understanding the mechanisms through which abortion access affects cohort outcomes, and use that framework to both address inconsistent past methodological approaches, and provide evidence on the long-run...

  10. THE OUTCOME OF PREGNANCY IN PATIENTS WITH THREATENED ABORTION

    Prathap

    2015-10-01

    Full Text Available OBJECTIVE: To assess the Outcome of pregnancy in patients with threatened abortion. METHODS: A Prospective observational study was done on 106 pregnant women with threatened abortion. Out comes in the form of antenatal complications, mode of delivery and postnatal co mplications were noted. Analysis of the data was done using SPSS version 13. RESULTS: In the study of 106 patients 18% had spontaneous abortion. Pre - labour rupture of membranes were seen in 20% of patients and 21% had preterm labour. Threatened abortion di d not affect mode of delivery. PPROM, preterm births were more in women presenting with first trimester bleeding; PIH, PROM, and postpartum complications were more in women presenting beyond 20 weeks gestation though statistically not significant. 13.2% of women had heavy bleeding at admission out of which 50% aborted subsequently – significantly higher than the light bleeding group. CONCLUSION: The overall maternal and perinatal outcome in women with threatened abortion is suboptimal. Women with heavy blee ding are more likely to abort than women with light bleeding. Among the prognostic factors, only the amount of bleeding had significant prognostic accuracy

  11. Medical Abortion in Primary Care : Pitfalls and Benefits

    Boersma, A. A.; Meyboom-de Jong, B.

    2009-01-01

    We describe jive pitfalls of medical abortion: ectopic pregnancy not terminated after misoprostol, but without negative side-effects; long-term vaginal blood loss with suspicious retained products which disappeared spontaneously; a patient with uterus myomatatosus with severe pain and retained produ

  12. 自然流产胚胎组织中人类纺锤体有丝分裂俘获缺陷基因的表达及意义%Expression of human spindle mitosis arrest deficiency gene in spontaneous abortion embryo tissues

    蔡燕; 王箭; 袁泰先; 施琼; 翁亚光; 王应雄; 蒋洪彦; 刘子杰

    2008-01-01

    Objective To investigate the expression of human spindle mitosis arrest deficiency gene (hsMAD2)in spontaneous abortion embryos and the relationship between low expression of hsMAD2 and numerical chromosomal aberration. Methods Spontaneous abortion embryo tissues were collected,including 23 cases of once spontaneous abortion tissue and 10 cases of twice or more spontaneous abortion tissue and induced abortion embryos(35 cases)from the Department of Gynaecology and Obstetrics of the Affilisted Hospitals of Chongqing University of Medical Science during the period of March 2006 to March 2007.FQ-PCR and western blot were used to evaluate the endogenous expression level of hsMAD2 mRNA and hsMAD2 protein;primary culturing of cells from the induced abortion embryos was conducted and 5 embryonic cells were selected by chromosomes karyotype analysis.Recombinant shRNA plasmids targeting hsMAD2 gene were constructed to inhibit the expression of endogenous hsMAIY2 genes in embryonic cells which have normal karyotypes;the groups were defined as the first experimental group(transfeeted with pshRNA-hsMAD2-1),the second experimental group(transfected with pshRNA-hsMAD2-2),the third experimental group(transfected with pshRNA-hsMAD2-3),the first control group(transfected with nothing),the second control group(transfected with pTZU6+1)and the independent group(transfected with pshRNA-N1).Interference efficiency was demonstrated by FQ-PCR and western blot:cell prolireration was meagured by methyl thiazolyl tetrazolium(MTT)assay;cell-cycle was assessed by flow cytometry (FCM):the chromosome numbers were calculated to analyze the variation of chromosomes.Results(1) The mRNA levels of hsMAD2 in the once spontaneous abortion tissue,twice or more spontaneous abortion tissue and indueed abortion tissue were 0.00879±0.00035.0.00901±0.00033 and 0.00941±0.00026 respectively,and there Wag no significant ditierence(P>0.05)compared with each other;however,the protein levels of hsMAD2 in

  13. Association between history of abortion and metabolic syndrome in middle-aged and elderly Chinese women.

    Xu, Baihui; Zhang, Jie; Xu, Yu; Lu, Jieli; Xu, Min; Chen, Yuhong; Bi, Yufang; Ning, Guang

    2013-03-01

    Epidemiologic studies have suggested that abortion may cause long term health consequences such as cardiovascular disease. Until recently, studies focusing on the association between history of abortion and metabolic diseases were limited. In the present study, we aimed to investigate the association between history of abortion and metabolic syndrome (MetS) in middle-aged and elderly Chinese women. A cross-sectional survey was performed in 6302 women (age ≥ 40 years) in Shanghai. Standardized questionnaire was used to obtain the information about reproductive histories. Overall, we observed a positive association between history of induced abortion and the prevalence of MetS, independent of potential confounding factors. A multivariable-adjusted logistic regression analysis revealed that compared to those without a history of induced abortion, women with a history of induced abortion remained at 1.25 times more likely to have MetS (OR = 1.25, 95% CI = 1.06-1.47, P abortion and the prevalence of MetS was observed. Compared to those without a history of spontaneous abortion, the multivariate-adjusted odds ratio associated with a history of spontaneous abortion for MetS was 0.88 (95% CI = 0.65-1.19, P > 0.05).

  14. Clinical Application of Low Molecular Weight Heparin in Patients with Recurrent Spontaneous Abortion%低分子肝素在复发性流产患者中的临床应用研究

    王岚; 任小青; 苏胜红; 吴坚

    2016-01-01

    ObjectiveTo analyze the efficacy and safety of low molecular weight heparin in the treatment of recurrent abortion. MethodsFrom January 2010 - June 2014 in our hospital to prevent abortion 78 cases of recurrent abortion, randomly divided into treatment group and control group, the control group received routine tocolysis medicine progesterone and chorionic gonadotropin and vitamin E, the treatment group in medicine based on the use of low molecular weight heparin calcium 0.4-0.8mg/d,for 13 weeks. Comparing the two groups of tocolysis success rate and efficacy of low molecular weight heparin drug side effects .ResultsThe living rate of the treatment group was 95.00%, the control group was 76.32%, the difference was statistically significant (P 0.05). ConclusionLow molecular weight heparin can be effective in the treatment of RSA,improve the pregnancy success rate of RSA women. Low molecular weight heparin is less adverse reactions during pregnancy, do a good job in monitoring, can be used in pregnancy safety. Some patients use process will produce slight side effects, should strengthen the monitoring of drug use.%目的:分析探讨低分子肝素对复发性流产的治疗效果及安全性。方法选取2010年1月至2014年6月在本院安胎的复发性流产患者78例,随机分为治疗组和对照组,给予对照组常规安胎药黄体酮、绒毛膜促性腺激素及维生素E,治疗组在上药基础上加用低分子肝素钙0.4-0.8mg/日,用至13周。对比两组的安胎成功率及观察低分子肝素药物副作用。结果治疗组的活胎率95.00%,对照组为76.32%,差异有统计学意义(P<0.05);安胎成功38例治疗前与治疗后1月D2聚体数值差异有统计学意义(P<0.05);治疗组治疗前后APTT、PLT数值差异无统计学意义(P>0.05)。结论低分子肝素可以有效治疗RSA,提高RSA妇女妊娠成功率。低分子肝素在妊娠期应用不良反应少,做好监测,可于孕期

  15. Cytogenetic and morphologic study of spontaneous abortions products in Medellín, Colombia Estudio citogenético y morfológico en productos de aborto espontáneo procedentes de diferentes servicios de ginecoobstetricia de la ciudad de Medellín

    Bernardo Agudelo Jaramillo

    1998-04-01

    Full Text Available Eighty tour spontaneous abortion products, with gestational age under 20 weeks, were collected in ditterent obstetric and gynecologic services trom Medellin-Colombia between September 1996 and October 1997; they were studied both morphologically and cytogenetically. Sixteen of those products were discarded because of contamination or absence of suitable tissues for the study In 60 of the remaining 68 products (88°/~ cultures for cytogenetic studies were establishedJ and they were succesful in 34 cases (56J7%. Seventeen of. these (50% showed an abnormal karyotype with the following chromosomal anomalies: X monosomies 10 (58J8%, mosaicisms 5 (29,4%J trisomies 1 (5,9%, and tetráploidy 1 (5J9%. From the 68 products, a morphologic study was performed in 21 cases (3 embryos and 18 fetuses. Twelve products (2 embryos and 10 fetuses; 57 J 1 % had external and/or jnternal anomalies This study of spontaneous abortions with gestational age under 20 weeks is the first in our country, and its results are similar to those published from other centers. En el período comprendido entre septiembre 1° de 1996 y octubre 1° de 1997, se recolectó para estudios morfológico y citogenético un total de 84 productos de aborto espontáneo del 1° y 2° trimestres de la gestación, en diferentes servicios de ginecoobstetricia de la ciudad de Medellín. Dieciséis de los 84 se descartaron por contaminación o ausencia de tejidos apropiados para el estudio. De los 68 productos restantes en 60 (88,2% se establecieron cultivos para estudio citogenético, los cuales fueron exitosos en 34 casos (56, 7%. Diecisiete de los anteriores (50% mostraron un cariotipo anormal con las siguientes alteraciones cromosómicas: monosomía X, 10 (58,8%, mosaicismos 5 (29,4%, trisomías 1 (5,9% y tetraploidía 1 (5,9%. En 21 de los 68 productos (30,9% (3 embriones y 18 fetos fue posible el estudio morfológico. Doce de éstos, (2 embriones y 10 fetos; 57, 1 % mostraron alteraciones morfol

  16. FISH快速检测自然流产绒毛染色体非整倍体异常的临床价值%Rapid Detection of Chromosomal Aneuploidy in Chorionic Villus of Spontaneous Abortion by Fluorescence in Situ Hybridization

    吴庆华; 史惠蓉; 解艳华; 江淼; 赵振华; 鲁宁; 孔祥东

    2012-01-01

    目的:探讨应用荧光原位杂交技术( FISH)对早期自然流产绒毛染色体非整倍体检测的临床价值.方法:对30例因自然流产行清宫术的绒毛组织行FISH分析,使用7种探针对13、16、18、21、22号和X、Y染色体进行了检测,并对这30例流产夫妇行外周血淋巴细胞染色体常规核型分析.结果:FISH分析的30例自然流产的绒毛组织中,有17例检测出了异常信号,检出率为57%,其中8例16-三体、2例22-三体、2例13-三体和5例三倍体.30例自然流产夫妇外周血淋巴细胞染色体核型未见异常.结论:FISH技术可以快速、简便地检测出流产物绒毛组织染色体非整倍体的异常,FISH技术的应用可以为自然流产夫妇遗传咨询提供重要的信息.%Objective;To evaluate the application of fluorescence in situ hybridization (FISH) for the detection of chromosomal aneuploidy in chorionic villus of spontaneous abortion. Methods:Thirty cases of chori-onic villus were analyzed by FISH, and seven probes were used to detect chromosomes 13, 16, 18, 21, 22, X, Y respectively. Results:In the thirty cases, seventeen cases were shown abnormal signals by FISH with detection rate of 57%, including eight cases of 16-trisomy, two cases of 22-trisomy, two cases of 13-trisomy and five cases of triploidy. Conclusions:FISH analysis is a rapid and easy method in the detection of chromosomal aneuploidy in chorionic villus. The application of FISH can provide important information of genetic counseling for the patients with spontaneous abortion.

  17. Induced abortion and psychosexuality.

    Bianchi-Demicheli, F; Kulier, R; Perrin, E; Campana, A

    2000-12-01

    Little information exists on the impact of induced abortion on psychosexuality. Negative psychological effects and psychiatric complications due to termination of pregnancy seem to be rare. The objective of this study was to review the impact of induced abortion on sexuality and couple relationships. A systematic search of the literature was performed. Studies had to report a quantitative or qualitative evaluation of sexuality after pregnancy termination. Four studies were included. In the one prospective study using a control group, no difference in sexual functioning between groups after 1 year was reported. In the remaining observational studies, sexual dysfunction was reported in up to 30% of women after termination. Women undergoing abortion had significantly more conflicts in their partnerships. This was similar in all studies. Separation occurred in about one-quarter of all couples. Some studies report sexual dysfunction after termination of pregnancy. In about half of the couples separated after termination, abortion seemed not to have led to the separation. Psychological factors, together with relationship problems, might have played a role in failed contraception. The impact of induced abortion on sexuality needs to be studied in greater detail with rigorous methodology to draw firm conclusions.

  18. Legal abortion in Georgia, 1980.

    Spitz, A M; Oberle, M; Zaro, S M

    1984-02-01

    According to data reported to the Georgia Department of Human Resources (DHR), the number of induced abortions performedin Georgia in 1980 decreased for the 1st time since 1968 when the state legalized abortion. To verify this reported decrease, the DHR data were compared with statistics obtained by the Alan Guttmacher Institute in a 1980 survey of abortion providers in Georgia. Since the AGI contacts providers directly, its statistics are considered a more accurate reflection of abortions performed. According to the DHR, the number of abortions dropped from 36,579 in 1979 to 33,288 in 1980, a 9% decrease, and the abortion rate fell from 26.6/1000 women ages 15-44 years to 23.9/1000. AGI data indicated a drop from 38,760 abortions in 1979 to 37,890 in 1980, a 2% decrease. Since both sources noted a similar trend despite differences in data collection methods, the 1980 decline in abortion procedures in Georgia is considered to represent a true decline rather than s statistical artifact. The sociodemographic characteristics of women obtaining abortions in Georgia in 1980 were also analyzed on the basis of DHR data. Although the number of abortions in Georgia performed on Georgia residents increased 2.5% from 1979-80 to 90.7%, the abortion ratio for residents decreased from 367.7 to 327.4 abortions/1000 live births. There was little change in the age, race, or marital status distribution of women receiving abortions. The ratio for white women was 317 abortions/1000 live births and that for blacks was 342/1000. The abortion ratio for unmarried women (1166/1000) was 13 times that for married women (88/1000). The number of repeat abortions decreased form 34% in 1979 to 29% in 1980. Moreover, 93% of women obtaining abortions did so in the 1st 12 weeks of gestation compared with 89% in 1979. The percentage of abortions performed in clinics increased from 66.5% in 1979 to 75.3% in 1980, with suction curettage accounting for 85% of all abortions in the 1st 12 weeks of

  19. The Response of Abortion Demand to Changes in Abortion Costs

    Medoff, Marshall H.

    2008-01-01

    This study uses pooled cross-section time-series data, over the years 1982, 1992 and 2000, to estimate the impact of various restrictive abortion laws on the demand for abortion. This study complements and extends prior research by explicitly including the price of obtaining an abortion in the estimation. The empirical results show that the real…

  20. Hospital admission following induced abortion in Eastern Highlands Province, Papua New Guinea--a descriptive study.

    Lisa M Vallely

    Full Text Available In Papua New Guinea abortion is restricted under the Criminal Code Act. While safe abortions should available in certain situations, frequently they are not available to the majority of women. Sepsis from unsafe abortion is a leading cause of maternal mortality. Our findings form part of a wider, mixed methods study designed to identify complications requiring hospital treatment for post abortion care and to explore the circumstances surrounding unsafe abortion.Through a six month prospective study we identified all women presenting to the Eastern Highlands Provincial Hospital following spontaneous and induced abortions. We undertook semi-structured interviews with women and reviewed individual case notes, extracting demographic and clinical information.Case notes were reviewed for 56% (67/119 of women presenting for post abortion care. At least 24% (28/119 of these admissions were due to induced abortion. Women presenting following induced abortions were significantly more likely to be younger, single, in education at the time of the abortion and report that the baby was unplanned and unwanted, compared to those reporting spontaneous abortion. Obtained illegally, misoprostol was the method most frequently used to end the pregnancy. Physical and mechanical means and traditional herbs were also widely reported.In a country with a low contraceptive prevalence rate and high unmet need for family planning, all reproductive age women need access to contraceptive information and services to avoid, postpone or space pregnancies. In the absence of this, women are resorting to unsafe means to end an unwanted pregnancy, putting their lives at risk and putting an increased strain on an already struggling health system. Women in this setting need access to safe, effective means of abortion.

  1. Abortion and human rights.

    Shaw, Dorothy

    2010-10-01

    Abortion has been a reality in women's lives since the beginning of recorded history, typically with a high risk of fatal consequences, until the last century when evolutions in the field of medicine, including techniques of safe abortion and effective methods of family planning, could have ended the need to seek unsafe abortion. The context of women's lives globally is an important but often ignored variable, increasingly recognised in evolving human rights especially related to gender and reproduction. International and regional human rights instruments are being invoked where national laws result in violations of human rights such as health and life. The individual right to conscientious objection must be respected and better understood, and is not absolute. Health professional organisations have a role to play in clarifying responsibilities consistent with national laws and respecting reproductive rights. Seeking common ground using evidence rather than polarised opinion can assist the future focus.

  2. [Abortion and crime].

    Citoni, Guido

    2011-01-01

    In this article we address the issue, with a tentative empirical application to the Italian data, of the relationship, very debated mainly in north America, between abortion legalization and reduction of crime rates of youth. The rationale of this relationship is that there is a causal factor at work: the more unwanted pregnancies aborted, the less unwanted children breeding their criminal attitude in an hostile/deprived family environment. Many methodological and empirical criticisms have been raised against the proof of the existence of such a relationship: our attempt to test if this link is valid for Italy cannot endorse its existence. The data we used made necessary some assumptions and the reliability of official estimates of crime rates was debatable (probably downward biased). We conclude that, at least for Italy, the suggested relationship is unproven: other reasons for the need of legal abortion have been and should be put forward.

  3. Did Legalized Abortion Lower Crime?

    2001-01-01

    This paper examines the relationship between the legalization of abortion and subsequent decreases in crime. In a current study, researchers estimate that the legalization of abortion explains over half of the recent decline in national crime rates. The association is identified by correlating changes in crime with changes in the abortion ratio weighted by the proportion of the criminal population exposed to legalized abortion. In this paper, I use an alternative identification strategy. I an...

  4. A Shiite perspective toward abortion

    Kiarash Aramesh

    2006-01-01

    All schools of Islamic jurisprudence regard abortion as wrong and forbidden and allow abortion only before the stage of ensoulment, if the continuation of pregnancy would endanger the mother's life or put her into intolerable difficulties. In this article we describe and assess the viewpoint of Shiite jurisprudence toward abortion. "nUsing a selected collection of related references, and discussion describes with experts, this article the abortion in Shiite jurisprudence."nIn t...

  5. Abortion — facts and consequences

    Perinčić, Robert

    1990-01-01

    The author sets forth some of the most recent demographic data, important directions of legal documents as regards abortion, tackling medical and ethical problems of abortion. Some essentials particulars are also given as to the embryonic and foetal development. The whole paper concerns the problems of legal abortion during the first three months of pregnancy. The second part of the paper relates to the consequences of abortion affecting the physical and mental health of a woman as show...

  6. Study of karyotypes in Case of Recurrent Abortions in Gujarat

    N. Parikh

    2015-06-01

    Full Text Available Introduction: - The biological definition of miscarriage is the expulsion of the conceptus before viability has been achieved. The definition of recurrent miscarriage is three or more consecutive spontaneous abortions. The risk factors for recurrent miscarriage are epidemiological, genetic, anatomical disorders, endocrinal, reproductive tract infections, thrombophilic disorders, disorders of materno-fetal alloimmune relationships, environmental effects and psychological causes. About 50% to 60% of all first trimester abortions are associated with derangement of one or more chromosomal complements. Aim: - The aim of this study was to assess frequency and increasing the awareness of physician about the nature of chromosomal aberration that contribute to the occurrence of repeated abortions. Material & Methods: - Patient of recurrent abortion was investigated by history taking, examination and investigations. For present study 20 women having two or more consecutive spontaneous abortions, who attended outdoor & indoor patient department, were selected and karyotyping was done. In 10 of the above cases karyotype study of both partners was done. So in total 30 individuals (20 females & 10 males were selected for Cytogenetic study. In all cases relevant history and clinical findings and other investigations were noted. Blood samples were obtained and karyotype study was performed at Genetic Laboratory, B. J. Medical College, Ahmedabad. Results and Conclusions: - Cytogenetic evaluation by karyotypes revealed robertsonian translocation in one (5% female; this patient had a history of 2 spontaneous abortions and two times IVF failure, she had history of chocolate cyst of ovary and family history of infertility. No numerical anomaly; mosaicism or inversions were found in this study; 23 cases had normal karyotype and remaining 6 cases came out inconclusive.

  7. Space Shuttle Abort Evolution

    Henderson, Edward M.; Nguyen, Tri X.

    2011-01-01

    This paper documents some of the evolutionary steps in developing a rigorous Space Shuttle launch abort capability. The paper addresses the abort strategy during the design and development and how it evolved during Shuttle flight operations. The Space Shuttle Program made numerous adjustments in both the flight hardware and software as the knowledge of the actual flight environment grew. When failures occurred, corrections and improvements were made to avoid a reoccurrence and to provide added capability for crew survival. Finally some lessons learned are summarized for future human launch vehicle designers to consider.

  8. 补肾安胎冲剂联合免疫疗法治疗反复自然流产40例%Bushen Antai Granules Combined with Immunotherapy in Treatment of Recurrent Spontaneous Abortion : A Report of 40 Cases

    周先韦; 李伟莉; 汪丹; 万春艳; 王金芳; 吴海燕

    2011-01-01

    Objective To observe the clinical effects of Bushen Antai Granules, a traditional Chinese prescription for supplementing kidney to prevent abortion, combined with immunotherapy in treating recurrent spontaneous abortion (RSA). Methods Eighty RSA patients with low blocking antibody were randomly divided into the comprehensive treatment group (40 cases) and the control group (40 cases). Patients in the control group were treated by active immunotherapy with hypodermic injection of their husbands' lymphocytes; while patients in comprehensive treatment group were treated with Bushen Antai Granules combined with active immunotherapy. Before and after treatment, the positive conversion rate of blocking antibody (indicated by death rate of lymphocytes under microscope) and successful pregnancy rate were observed and compared between the two groups. Results At the end of first treatment course, the positive conversion rates of blocking antibody were 95.00% and 80.00% in the comprehensive treatment group and the control group, respectively; and the successful pregnancy rates were 94.74% and 75.00%,respectively. The positive conversion rate of blocking antibody, successful pregnancy rate and death rate of lymphocytes in the comprehensive treatment group were significantly higher than those in the control group (P<0.05). Conclusion Bushen Antai Granules combined with active immunotherapy is superior to single immunotherapy in promoting the production of blocking antibody and improving successful pregnancy rate in RSA patients.%目的 观察补肾安胎冲剂联合免疫疗法治疗反复自然流产(recurrent spontaneous abortion,RSA)的临床疗效.方法 收集封闭抗体低下型RSA患者80例,随机分成综合治疗组、单纯淋巴细胞治疗对照组各40例,对照组采用丈夫淋巴细胞皮下注射主动免疫疗法;综合治疗组在对照组基础上加服补肾安胎冲剂,比较治疗前后两组封闭抗体(微淋巴细胞毒试验镜下细胞

  9. B 族维生素干预后血清同型半胱氨酸水平对早期反复流产患者保胎效果的影响%The effect of plasma homocystein levels after vitamin B intervention on patients with early recurrent spontaneous abortion

    杜艳; 王金兰

    2014-01-01

    目的:探讨B族维生素干预后血清同型半胱氨酸水平对早期反复流产患者保胎效果的影响。方法排除导致自然流产其它因素,选择血清同型半胱氨酸水平在10μmol/L及以上的患者80例,随机分为两组,治疗组40例孕前给予B族维生素治疗1月后复查血清同型半胱氨酸水平并继续服用上述药物至妊娠12周;对照组40例孕前后均不予上述药物治疗。孕后两组均常规保胎观察至妊娠12周,行B超检查证实活胎并胎儿发育正常者为保胎成功。结果治疗组服用B族维生素1月后血清同型半胱氨酸水平平均下降44%,妊娠36例,保胎成功30例,保胎成功率83%;对照组妊娠32例,保胎成功18例,保胎成功率56%。结论对于早期反复流产患者,B族维生素可有效降低血清同型半胱氨酸水平,并可有效提高保胎成功率。%Objective To investigate the effect of plasma homocystein levels after vitamin B intervention on patients with ear‐ly recurrent spontaneous abortion .Methods 80 patients of Plasma homocystein level ≥10μmol/L with early recurrent sponta‐neous abortion excluding other factors were selected .They were divided into a treatment group (n=40) which took Plasma ho‐mocystein level after taking vitamin B one month before prognancy then continued to take them till 12 th week of pregnancy and a control group(n=40) which took no medicine before and after pregnancy .Two groups were routine tocolysis for up to 12 weeks after pregnancy .The normal fetal development was considered successful tocolysis after B‐ultrasonography examination . Results Homocystein levels in treatment group dropped by an average of 44% after taking vitamin B one month .Tocolysis suc‐cessful rate was 83% in 36 cases of pregnancy ,which was different from that in 32 cases of pregnancy of the control group (56% ) .Conclusion Vitamin B could reduce homocystein levels of patients with early recurrent

  10. Abortion and compelled physician speech.

    Orentlicher, David

    2015-01-01

    Informed consent mandates for abortion providers may infringe the First Amendment's freedom of speech. On the other hand, they may reinforce the physician's duty to obtain informed consent. Courts can promote both doctrines by ensuring that compelled physician speech pertains to medical facts about abortion rather than abortion ideology and that compelled speech is truthful and not misleading.

  11. Did Legalized Abortion Lower Crime?

    Joyce, Ted

    2004-01-01

    Changes in homicide and arrest rates were compared among cohorts born before and after legalization of abortion and those who were unexposed to legalized abortion. It was found that legalized abortion improved the lives of many women as they could avoid unwanted births.

  12. Abortion and contraceptive failure.

    1998-01-01

    Persona, marketed by Unipath, is a new method of natural family planning which has been on the market since 1996. It works by measuring the hormone levels in a woman's urine and letting her know when she is not fertile and may have sex without using a barrier method of contraception. The British Pregnancy Advisory Service (BPAS) found that their surveyed clients who reported using Persona had 188 abortions in 3 months and concluded that there was a need for better information and more advice for couples who plan to use the method. The other major non-NHS abortion provider, Marie Stopes International, reported similar findings, with about 60 women per month visiting their clinics for abortions after having used the method. The BPAS survey also showed that 43% of the women who had an abortion after using Persona were aged 24 years or younger even though Persona is intended for use by women aged 25-40 years in stable relationships. A similar proportion also reported having sex on days when the method told them that they were most fertile. These latter women were not asked if they used another method of contraception on fertile days. An additional 13% reported ignoring the instructions to wait for 3 natural periods after terminating pill use before beginning to use Persona.

  13. Abortion: Strong's counterexamples fail

    Di Nucci, Ezio

    2009-01-01

    This paper shows that the counterexamples proposed by Strong in 2008 in the Journal of Medical Ethics to Marquis's argument against abortion fail. Strong's basic idea is that there are cases--for example, terminally ill patients--where killing an adult human being is prima facie seriously morally...

  14. [Abortion and conscientious objection].

    Czarkowski, Marek

    2015-03-01

    Polish laws specify the parties responsible for lawful medical care in the availability of abortion differently than the Resolution of the Council of Europe. According to Polish regulations they include all Polish doctors while according to the Resolution, the state. Polish rules should not discriminate against anyone in connection with his religion or belief, even more so because the issue of abortion is an example of an unresolved ethical dispute. The number of lawful abortion in Poland does not exceed 1000 per year and can be carried out by only a few specialists contracted by the National Health Fund. Sufficient information and assistance should be provided to all pregnant women by the National Health Fund. The participation of all physicians in the informing process is not necessary, as evidenced by the lack of complaints to provide information on where in vitro fertilization treatment can be found - until recently only available when paid for by the individual and performed in much larger numbers than abortion. Entities performing this paid procedure made sure to provide information on their own. The rejection of the right to the conscientious objection clause by negating the right to refuse information may lead some to give up the profession or cause the termination of certain professionals on the basis of the professed worldview. Meanwhile, doctors are not allowed to be discriminated against on the basis of their conscience or religion.

  15. Swedish students' attitudes toward abortion.

    Lindell, M E; Olsson, H M

    1993-01-01

    The Swedish abortion legislation of 1975 gave women the right to make a decision about abortion before the end of the 18th week of pregnancy. The number of abortions is rising in Sweden as a chosen method of birth control. The attitudes of students toward abortion were studied in 1986-1987. A questionnaire containing items on how sex education is taught, the anatomy and physiology of reproduction, contraceptives, sexually transmitted diseases, and legal abortion was answered by 421 high school students. Results pertaining to the students' attitudes toward abortion are reported. Two thirds of the students believed that the decision about an abortion should be made by the man and woman together. Nearly all respondents believed that abortion should not be considered a method of birth control. These results may be considered a guide for interventions to prevent the need for abortion. One fourth of all pregnancies in Sweden terminate in abortion. The students in the present study thought of abortion as a solution. Authors studying samples with different cultural backgrounds have reported similar attitudes.

  16. Intervention of Integrated Chinese and Western Medicine on Prethrombotic State in Recurrent Spontaneous Abortion with Yangxue Antai Granules%养血安胎颗粒对复发性流产血栓前状态的中西结合干预模式的建立

    何军琴; 武颖; 梁欣韫; 李玛建; 王玉雯; 高爱萍; 黄醒华; 王树玉; 张莹; 杨维; 辛明蔚

    2014-01-01

    目的:通过对复发性流产患者血栓前状态的相关血栓标志物进行筛查,验证中医瘀血型辨证与其相关性,建立养血安胎颗粒对其规范化的治疗模式。方法将1497例自然流产患者按流产次数分为1次、2次、3次及以上,分别检测抗凝血酶Ⅲ(AT -Ⅲ)、纤溶酶原(PLG)、交联纤维蛋白降解产物(DD)、纤溶酶原降解产物(FDP)、纤溶酶原活化物抑制因子-1(PAI -1)、组织型纤溶酶原激活物(t - PA)、蛋白 C(PC)、蛋白 S(PS)等血栓标志物。对入选289例复发性流产患者按照随机、对照原则分为中药治疗组(127例)和西药治疗组(162例),观察养血安胎颗粒和阿司匹林对复发性流产血栓前状态的疗效。结果 AT -Ⅲ、PAI -1对不良妊娠结局的影响具有统计学差异( P ﹤0.05),随着流产次数的增加特征性明显(P ﹤0.05);阿司匹林对 AT -Ⅲ的影响具有统计学意义(P ﹤0.05);养血安胎颗粒对 PAI -1的影响具有统计学意义(P ﹤0.01);各指标两组间治疗前后效果比较差异均无统计学意义(P ﹥0.05)。结论养血安胎颗粒通过养血活血、健脾补肾,调节止血-凝血-抗凝系统,改善复发性流产血栓前状态。%Objective To verify the correlation between blood stagnation in TCM and thrombotic markers by screening the relevant thrombotic markers in the patients of prethrombotic state(PTS)of recurrent spontaneous abortion(RSA)so as to establish the standard therapeutic mode with Yangxue Antai Granules. Methods One thousand nine hundred and ninety seven patients of spontaneous abortion were divided into groups according to the frequency of spontaneous abortion,such as 1 time,twice,three times or over 3 times. The thrombotic markers such as AT - III,PLG,DD,FDP,PAT - 1,t - PA,PC and PS were detected. The en-rolled 289 cases of RSA were randomized into a Chinese medicine group(127 cases)and a

  17. Austerity and Abortion in the European Union.

    2016-01-01

    : Economic hardship accompanying large recessions can lead families to terminate unplanned pregnancies. To assess whether abortions have risen during the recession, we collected crude abortion data from 2000 to 2012 from Eurostat for countries that had legal abortions and complete data. Declining trends in abortion ratios between 2000 and 2009 have been reversing. Excess abortions between 2010 and 2012 totaled 10.6 abortions per 1000 pregnancies ending in abortion or birth or 6701 additional ...

  18. 早期自然流产胎盘绒毛基质金属蛋白酶-2表达增强%Increased expression of MMP-2 in plancetal villi of early spontaneous abortion

    王乾兴; 谭兵兵; 谭晓珊; 杨高巧; 张先平

    2006-01-01

    早期自然流产(early spontaneous abortion)是指妊娠12周内胚胎或胎儿在宫内停止发育而排出的病理性妊娠,发生率占全部自然流产的62%以上.胎盘形成过程中,滋养层细胞对子宫蜕膜的侵入及对子宫螺旋小动脉的“血管重铸”是胎盘建成的关键步骤.基质金属蛋白酶(matrix metalloprotein-ases,MMPs)是一组含有Zn2+能降解绝大多数细胞外基质(extracellular,ECM)的肽链内切酶.研究证实,MMP-2和9是恒河猴滋养层细胞侵入子宫内膜和胎盘形成的关键因子,但对人早期自然流产过程中的表达情况尚未见报道.本研究首次采用明胶酶谱法研究早期自然流产胎盘绒毛中MMP-2和9的活性变化,以探讨其与早期自然流产的关系。

  19. The consequences of abortion legislation.

    Braude, M

    1983-01-01

    This article examines the consequences of the 1973 US Supreme Court decision legalizing abortion as well as potential implications of proposed legilation aimed at nullifying this decision. In addition to giving women the right to determine their own reproduction, legal abortion had had beneficial health effects for both mothers and infants. The partial reversal of abortion gains due to restrictions on public funding and limitations on how and where abortions can be performed has produced a slight increase in abortion mortality, but the impact has not been dramatic. Moreover, each year since 1973, women have been obtaining abortions earlier in pregnancy. Abortion may be experienced as a loss by the mother, but there is no evidence of serious psychological sequelae. In contrast, a large body of evidence supports the physical, psychological, and social benefits of legal abortion to women, children, and families. However, proponents of the proposed Human Life Amendment place protection of the rights of the fetus over all other considerations. Their antiabortion actions have challenged the medical tradition of privacy and the confidentiality of the doctor-patient relationship. Most supporters of legal abortion would prefer that there be fewer abortions; such a decrease is more likely as a result of better education and contraceptive methods rather than coercion.

  20. [Analysis of abortions at a community maternity hospital in Bangui].

    Sepou, A; Ngbale, R; Yanza, M C; Domande-Modanga, Z; Nguembi, E

    2004-01-01

    Abortion, i.e., early termination of pregnancy, has few complications when it occurs spontaneously. However self-inflicted abortion (SIA) often leads to more or less serious complications. In view of the increasing number of abortion cases in our department, we undertook this yearlong transversal study to evaluate the incidence of SIA in the department, determine the demographic characteristics of the women that practiced SIA, and identify the complications of SIA. Only ongoing or incomplete abortions were studied. Amenorrhea not related to pregnancy or associated with ectopic pregnancy was excluded from study. Clinical and demographic data were noted on forms specially designed by the research team. Data analysis yielded the following findings. Abortion accounted for 719 of the 5292 hospitalizations (13.6%) in gynecology unit, including 43.4% of SIA. Mean patient age was 24.7 years (range, 13 to 39). Spontaneous abortion was more likely to be observed in married women than in students who usually presented SIA. Wanted pregnancy was more likely to be reported by married women than by single woman who posed the problem of unwanted pregnancy. Students had more SIA. The main reasons for practicing SIA were financial (61.5%). The most common methods used for SIA were drug combinations (39.1%) and mechanical tools (26.0%). All severe complications such as infection and death were observed in women who practiced SIA. The high incidence of SIA in the department was especially disturbing due to the young age of the women involved and the severity of the complications. More action is needed to spread information on contraceptive methods in schools and universities to avoid unintended pregnancies that drive young people to practice SIA.

  1. Austerity and Abortion in the European Union.

    Lima, Joana Madureira; Reeves, Aaron; Billari, Francesco; McKee, Martin; Stuckler, David

    2016-06-01

    Economic hardship accompanying large recessions can lead families to terminate unplanned pregnancies. To assess whether abortions have risen during the recession, we collected crude abortion data from 2000 to 2012 from Eurostat for countries that had legal abortions and complete data. Declining trends in abortion ratios between 2000 and 2009 have been reversing. Excess abortions between 2010 and 2012 totaled 10.6 abortions per 1000 pregnancies ending in abortion or birth or 6701 additional abortions (95% CI 1190-9240) with stronger effects in younger ages. Economic shocks may increase recourse to abortion. Further research should explore causal pathways and protective factors.

  2. 低分子肝素联合小剂量阿司匹林对复发性流产患者激素水平、免疫功能的影响%Effect of low molecular weight heparin combined with low dose aspirin on hormone level and immune function in patients with recurrent spontaneous abortion

    张高; 程玲慧

    2015-01-01

    目的:探讨低分子肝素联合小剂量阿司匹林对复发性流产患者激素水平、免疫功能的影响。方法选取2013年1月~2014年12月就诊的118例复发性流产患者为研究对象,采用随机数字表法分为观察组和对照组各59例。对照组采用小剂量阿司匹林治疗,观察组采用低分子肝素联合小剂量阿司匹林治疗。比较2组激素水平、免疫功能、治疗效果。结果临床疗效:观察组患者保胎成功率86.44%明显高于对照组55.93%(χ2=13.387,P<0.05);激素水平:观察组血清绒毛膜促性腺激素( human choionic gonadotophin,HCG)、孕酮(progesterone,P)、雌二醇(estradiol,E2)含量含量均明显高于对照组(P<0.05);免疫功能:观察组干扰素-γ(interferon-γ,IFN-γ)明显低于对照组(P<0.05),白细胞介素-4(interleukin-4,IL-4)明显高于对照组(P<0.05),IFN-γ/IL-4明显低于对照组(P<0.05);不良反应:2组不良反应比较差异无统计学意义(22.03%vs 15.25%)(χ2=0.894,P>0.05)。结论低分子肝素联合小剂量阿司匹林治疗有助于改善复发性流产孕妇激素水平与免疫功能,提高保胎成功率。%Objective To study effect of low molecular weight heparin combined with aspirin on hormone level and immune function in treatment of recurrent spontaneous abortion.Methods 118 cases patients with recurrent spontaneous abortion from January 2013 to December 2013 were divided into observation group and control group, control group was given low-dose aspirin therapy, observation group was given low molecular weight heparin combined with low-dose aspirin.hormone levels, immune function, therapy effect were compared between two groups.Result Clinical curative effect:observation group prevent miscarriage success rate 86.44% was significantly higher than control group 55.93%(χ2 =13.387, P0.05).Conclusion

  3. Clinical significance of co-measurement of three different serum antibodies in women with recurrent spontaneous abortion%复发性流产患者联合检测三种血清自身抗体及临床意义

    郑建琼; 沈晓露; 朱雪琼; 郑加永; 徐芳

    2012-01-01

    目的:探讨血清抗心磷脂抗体(anticardiolipin antibody,ACL)、抗β2-糖蛋白Ⅰ抗体(anti-beta2-glycoproteinI antibody,抗β2-GPI抗体)和狼疮抗凝物(lupus anticoagulant antibody,LAC)联合检测对复发性流产(reeurrent spontaneous abortion,RSA)的预测意义.方法:选取85例RSA患者为实验组,50例正常经产妇作为对照组,检测两组血清ACL、抗β2-GP1抗体和LAC水平.结果:RSA组ACL阳性率为27.06%(23/85),而对照组为8%(4/50),差异有统计学意义(P<0.01);抗β2-GPI抗体阳性率为21.18%(18/85),而对照组2%(1/50),差异有统计学意义(P< 0.01);LAC阳性率为21.18%(18/85),而对照组为6%(3/50),差异有统计学意义(P<0.05).在确诊的40例抗磷脂抗体综合症患者中,ACL或抗β2-GPI抗体阳性率为95.00%(38/40),和ACL或LAC阳性组比较,差异有统计学意义(P<0.01);和抗β2-GPI抗体或LAC阳性组比较,差异有统计学意义(P<0.05).结论:(1) ACL、抗β2-GPI抗体和LAC均与RSA有关.(2)ACL和抗β2-GPI抗体联合检测可以提高RSA患者抗磷脂抗体综合症检出率,对于临床诊断和指导治疗有重要意义.%Objective To investigate the clinical value of co-measurement of anticardiolipin (ACL), anti-beta2-glycoprotein I, and lupus anticoagulant antibody (LAC) antibodies in women with recurrent spontaneous abortion (RSA). Methods Levels of ACL, anti-beta2-glycoprotein I and LAC antibodies in 85 women with RSA (RSA group) and 50 normal mukigravidas (control group) were detected. Results The positive rates of ACL, anti-beta2-glycoprotein I and LAC antibodies in RSA group and control group were 27.06% (23/85), 21.18% (18/85), 21.18% (18/85) and 8% (4/50), 2% (1 /50), 6% (3/50), respectively; And the differences between the two groups were significant (P < 0.01, P<0.01, P < 0.05). The positive rate of ACL or anti-beta2-glycoprotein I antibodies was 95.00% (38/40) in 40 women who were definitely diagnosed with antiphosphlipid syndrome (APS

  4. Abortion law reform in Nepal.

    Upreti, Melissa

    2014-08-01

    Across four decades of political and social action, Nepal changed from a country strongly enforcing oppressive abortion restrictions, causing many poor women's long imprisonment and high rates of abortion-related maternal mortality, into a modern democracy with a liberal abortion law. The medical and public health communities supported women's rights activists in invoking legal principles of equality and non-discrimination as a basis for change. Legislative reform of the criminal ban in 2002 and the adoption of an Interim Constitution recognizing women's reproductive rights as fundamental rights in 2007 inspired the Supreme Court in 2009 to rule that denial of women's access to abortion services because of poverty violated their constitutional rights. The government must now provide services under criteria for access without charge, and services must be decentralized to promote equitable access. A strong legal foundation now exists for progress in social justice to broaden abortion access and reduce abortion stigma.

  5. Abortion in a just society.

    Hunt, M E

    1993-01-01

    A female Catholic theologian imagines a just society that does not judge women who decide to undergo an abortion. The Church, practitioners, and the courts must trust that women do make person-enhancing choices about the quality of life. In the last 15 years most progress in securing a woman's right to abortion has been limited to white, well-educated, and middle or upper middle class women. A just society would consider reproductive options a human right. Abortion providers are examples of a move to a just society; they are committed to women's well-being. There are some facts that make one pessimistic about achieving abortion in a just society. The US Supreme Court plans to review important decisions establishing abortion as a civil right. Further, some men insist on suing women who want to make their own reproductive decisions--an anti-choice tactic to wear away women's right to reproductive choice. Bombings of abortion clinics and harassment campaigns by anti-choice groups are common. These behaviors strain pro-choice proponents emotionally, psychically, and spiritually. Their tactics often lead to theologians practicing self-censorship because they fear backlash. Abortion providers also do this. Further, the reaction to AIDS is that sex is bad. Anti-abortion groups use AIDS to further their campaigns, claiming that AIDS is a punishment for sex. Strategies working towards abortion in a just society should be education and persuasion of policymakers and citizens about women's right to choose, since they are the ones most affected by abortion. Moreover, only women can secure their rights to abortion. In a just society, every health maintenance organization, insurance company, and group practice would consider abortion a normal service. A just society provides for the survival needs of the most marginalized.

  6. 荧光原位杂交技术在自然流产绒毛染色体核型检测中的应用%Application of fluorescence in situ hybridization on detection of abnormal karyotypes from spontaneous abortion specimens

    刘丛丛; 刘俊涛; 宋亦军; 郝娜; 周京

    2012-01-01

    Objective To investigate the effect of fluorescence in situ hybridization (FISH) in increasing the accuracy and detection rate of chromosome aneuploid from spontaneous abortion specimens.Methods Chromosome 13,21,16 and 22 single sequence probes and centromere probes of 18,X and Y chromosome probes were used to detect 100 cases of spontaneous abortion villi samples.The results were compared with conventional karyotype analysis.Results (1) Karyotype analysis:Among 89 successfully cultured villi samples,51 abnormal karyotypes (57.3%) were found,including 37 cases of autosomal aneuploidies,four sex chromosome aneuploidies,two triploids,one tetraploid,one 68,XX and six chromosome structural aberrations.(2) FISH:The detection rate of abnormal karyotype was 38.0% (38/100),among which 25 cases were autosomal aneuploidies,five sex chromosome aneuploidies,three triploids,four XX chimeras and one triploid in chromosome 13,16,18 and 21.(3) Comparison of the two methods:Among the 11 samples which failed by conventional method,FISH found two abnormal samples.In specimens of 46,XY,three cases showed mosaicism by FISH.In specimens of 46,XX,two cases showed chromosomal abnormalities by FISH.FISH detected overall 65.5% (38/58) of the chromosomal abnormalities.Conclusions FISH combined with conventional chromosome analysis could improve the accuracy and detection rate of abnormal karyotypes in spontaneous abortion specimens.%目的 探讨荧光原位杂交(fluorescence in situ hybridization,FISH)技术在提高自然流产绒毛染色体核型分析准确性和异常核型检出率中的作用.方法 采用18、X、Y染色体着丝粒探针和13、21及16、22染色体单一序列探针,对100例自然流产绒毛标本同时进行FISH检测和常规染色体核型分析,比较并分析2种方法的一致性及差异.结果 (1)染色体核型分析:100例流产绒毛标本培养成功率为89.0%(89/100).检出异常核型51例,异常核型检出率为57.3%(51/89),

  7. Psychiatric sequelae of induced abortion.

    Gibbons, M

    1984-03-01

    An attempt is made to identify and document the problems of comparative evaluation of the more recent studies of psychiatric morbidity after abortion and to determine the current consensus so that when the results of the joint RCGP/RCOG study of the sequelae of induced abortion become available they can be viewed in a more informed context. The legalization of abortion has provided more opportunities for studies of subsequent morbidity. New laws have contributed to the changing attitudes of society, and the increasing acceptability of the operation has probably influenced the occurrence of psychiatric sequelae. The complexity of measuring psychiatric sequelae is evident from the many terms used to describe symptomatology and behavioral patterns and from the number of assessment techniques involved. Numerous techniques have been used to quantify psychiatric sequelae. Several authors conclude that few psychiatric problems follow an induced abortion, but many studies were deficient in methodology, material, or length of follow-up. A British study in 1975 reported a favorable outcome for a "representative sample" of 50 National Health Service patients: 68% of these patients had an absence of or only mild feelings of guilt, loss, or self reproach and considered abortion as the best solution to their problem. The 32% who had an adverse outcome reported moderate to severe feelings of guilt, regret, loss, and self reproach, and there was evidence of mental illness. In most of these cases the adverse outcome was related to the patient's environment since the abortion. A follow-up study of 126 women, which compared the overall reaction to therapeutic abortion between women with a history of previous mild psychiatric illness and those without reported that a significantly different emotional reaction could not be demonstrated between the 2 groups. In a survey among women seeking an abortion 271 who were referred for a psychiatric opinion regarding terminations of pregnancy

  8. A Shiite perspective toward abortion

    Kiarash Aramesh

    2006-03-01

    Full Text Available All schools of Islamic jurisprudence regard abortion as wrong and forbidden and allow abortion only before the stage of ensoulment, if the continuation of pregnancy would endanger the mother's life or put her into intolerable difficulties. In this article we describe and assess the viewpoint of Shiite jurisprudence toward abortion. "nUsing a selected collection of related references, and discussion describes with experts, this article the abortion in Shiite jurisprudence."nIn the Shiite jurisprudence, the ensoulment occurs after about 4 months. Before this stage, all Shiite authorities regard abortion as forbidden (Hiram unless if continuing the pregnancy would put the mother's life in real danger or will be intolerable for her. But after that, they regard abortion as Hiram, unless in conditions in which continuing the pregnancy results in dying of both mother and fetus, but abortion will save the life of mother. However, the Shiite authorities have not accepted to legitimate abortion in unwanted pregnancies and even in pregnancies resulted from adultery (Zina or rape."nThe debate over abortion is still controversial as ever. There are some important and notable related Fatwas that make jurisprudical basis for some new and problem solving legal acts, showing the inherent and valuable flexibility of the Shiite jurisprudence in dealing with such important issues. Some related issues, such as the priority of saving the life of mother after ensoulment can be referred to jurisprudical authorities for more assessment.

  9. The Impact of Legalized Abortion on Crime

    2000-01-01

    We offer evidence that legalized abortion has contributed significantly to recent crime reductions. Crime began to fall roughly 18 years after abortion legalization. The 5 states that allowed abortion in 1970 experienced declines earlier than the rest of the nation, which legalized in 1973 with Roe v. Wade. States with high abortion rates in the 1970s and 1980s experienced greater crime reductions in the 1990s. In high abortion states, only arrests of those born after abortion legaliz...

  10. Spontaneous pneumothorax

    Davari R

    1996-07-01

    Full Text Available A case with bilateral spontaneous pneumothorax was presented. Etiology, mechanism, and treatment were discussed on the review of literature. Spontaneous Pneumothorax is a clinical entity resulting from a sudden non traumatic rupture of the lung. Biach reported in 1880 that 78% of 916 patients with spontaneous pneumothorax had tuberculosis. Kjergaard emphasized 1932 the primary importance of subpleural bleb disease. Currently the clinical spectrum of spontaneous pneumothorax seems to have entered a third era with the recognition of the interstitial lung disease and AIDS as a significant etiology. Standard treatment is including: observation, thoracocentesis, tube thoracostomy. Chemical pleurodesis, bullectomy or wedge resection of lung with pleural abrasion and occasionally pleurectomy. Little information has been reported regarding the efficacy of such treatment in spontaneous pneumothorax secondary to non bleb disease

  11. Unsafe abortion in rural Tanzania

    Rasch, Vibeke; Sørensen, Pernille H; Wang, Anna R;

    2014-01-01

    BackgroundThe circumstances under which women obtain unsafe abortion vary and depend on the traditional methods known and the type of providers present. In rural Tanzania women often resort to traditional providers who use plant species as abortion remedies. Little is known about how these plants...

  12. Abortion, Birthright and the Counselor.

    Fadale, Vincent E.; And Others

    This transcript is the result of panel presentation given on the implications of liberalized abortion laws for counselors. A new law which went into effect in July, 1970, in New York State presented women with the option of obtaining a legal abortion up to the 24th week of pregnancy. Counselors in New York State were, therefore, presented with new…

  13. Abortion Information: A Guidance Viewpoint

    Wolleat, Patricia L.

    1975-01-01

    A number of questions relating to providing abortion information to teenagers can be raised from legal, ethical and philosophical standpoints. The purpose of this article is to examine abortion information-giving from the perspective of counseling and guidance theory and practice. (Author)

  14. 药物流产和人工流产的效果观察及护理%The Effect of Drug Abortion and Abortion Observation and Nursing

    李春柏

    2015-01-01

    目的:探讨药物流产和人工流产的临床效果,并分析不同患者相应的护理方法。方法选取我院于2012年9月~2014年9月收治的68例需要实施流产的患者,按照患者意愿的不同将其分为药物流产组和人工流产组,观察两组患者流产后的临床特征及表现,并对其护理情况进行分析。结果通过对两组患者施以不同流产方法,人工流产组34例患者均为完全流产,药物流产组完全流产为30例,数据对比差异有统计学意义(P<0.05)。结论通过研究发现,药物流产和人工流产两种方案各有优缺点,应根据孕妇的具体情况制定合适的流产方案,并给予患者相应的护理措施,缓解患者的情绪,促进患者的康复。%Objective To explore the clinical effect of drug abortion and artificial abortion, and analyze the nursing methods of patients with different corresponding. Methods Select our hospital from September 2012 to September 2014 patients treated 68 cases need to implement an abortion, according to the wishes of patients with different it can be divided into medical abortion and artiifcial abortion group, two groups of patients with spontaneous abortion after the clinical features and performance, and analyze the nursing status.ResultsBy means of two groups of patients with different methods of abortion, abortion group of 34 patients were completely abortion, complete abortion of 30 cases of medical abortion group, data contrast significant difference was statistically significant (P<0.05).Conclusion Through the study found that medical abortion and abortion two plans each have advantages and disadvantages, should be based on appropriate abortion of pregnant women, patients and give corresponding nursing measures, alleviate the mood of patients, promote the recovery of patients.

  15. Teenage pregnancies and abortion.

    Morgenthau, J E

    1984-01-01

    The issue of abortion, except when it is rendered moot because the fetus endangers the life of the mother, is not really a medical issue. The physician's role is to help patients achieve and maintain their maximum potential for physical, mental, and social well-being. To accomplish this, the physician must acquire a constantly evolving database of scientific knowledge, must evaluate this information in a critical and ethical manner, and must be prepared to apply what is learned. In the realm of applied ethics, no particular religion, profession, culture, class, or sex should be thought of as having all the answers in the realm of applied ethics. This physician's actions are predicated on the belief that, to a large extent, ethical precepts reflect the broader social and economic issues of the period in which they are articulated. If this is the case, then in today's world the population explosion, the postindustrial society, the women's rights movement, inequality of access, and the ability to perform prenatal diagnosis are all factors which have molded the approach to the issue of abortion. Only the last 3 of these can in any way be considered as medical. When considering the role of a physician in dealing with the issue of abortion in the adolescent, this individual relies on the concept articulated by the World Health Association (WHA): promoting the physical, emotional, and social well-being of one's patients. Each year in the US over 1 million 15-19 year olds become pregnant, resulting in over 600,000 births. Most of these pregnancies are unintentional, yet approximately 90% of the infants are kept in the home by mothers who are ill prepared to be parents. What is most disturbing is that the pregnancy rate for the younger mother, 16 years or under, is accounting for an ever increasing percentage of the total. Studies at the Adolescent Health Center of the Mount Sinai Hospital in New York City as well as national studies suggest that the younger teens are more

  16. Reducing abortion: the Danish experience.

    Risor, H

    1989-01-01

    In 1987, 20,830 legal abortions were performed in Denmark. 2,845 involved women below the age of 20, and 532 involved women terminating pregnancy after the 12th week. Danish law permits all of its female citizens to have an abortion free-of-charge before the 12th week of pregnancy. After the 12th week, the abortion must be applied for through a committee of 3 members, and all counties in Denmark have a committee. It is felt in Denmark that a woman has a right to an abortion if she decides to have one. It she makes that choice, doctors and nurses are supportive. Since 1970, sex education has been mandatory in Danish schools. Teachers often collaborate closely with school doctors and nurses in this education. All counties are required to have at least 1 clinic that provides contraceptive counselling. It was recently found that the lowest number of pregnancies among teenaged girls was found in a county in Jutland where all 9th grade students visit the county clinic to learn about contraceptives, pregnancy, and abortion. Within 1 year after Copenhagen had adopted this practice, the number of abortions among teenagers declined by 20%. One fourth of all pharmacies also collaborate with schools to promote sex education, instructing students about contraceptives and pregnancy tests. The Danish Family Planning Association has produced a film on abortion, and plans to produce videos on abortion for use in schools. The organization also holds training programs for health care personnel on contraception, pregnancy, and abortion. By means of the practices described above, it is hoped that the number of abortions and unwanted pregnancies in Denmark will be reduced.

  17. Republic of Ireland: abortion controversy.

    1998-01-01

    The problems associated with illegal abortion dominate public discussion in Ireland. While abortion is illegal in Ireland, the Supreme Court directed in 1992 that Irish women can go to Britain for abortions when their lives are thought to be at risk. Abortion was a constant feature during the Irish Presidential election campaign in October, while a dispute about the future of a 13-year-old girl's pregnancy dominated the headlines in November. The presidential election on October 30 resulted in a victory for one of the two openly anti-choice candidates, Mary McAleese, a lawyer from Northern Ireland. With a voter turnout of 47.6%, McAleese polled 45.2% of the votes cast. Although the president may refuse to sign bills which have been passed by parliament, McAleese has said that she will sign whatever bill is placed before her, even if it liberalizes abortion law in the republic. As for the case of the 13-year-old pregnant girl, she was taken into the care of Irish health authority officials once the case was reported to the police. However, the health board, as a state agency, is prevented by Irish law from helping anyone travel abroad for abortion. The girl was eventually given leave in a judgement by a High Court Judicial Review on November 28 to travel to England for an abortion.

  18. Relationship between the expression of chemokines and their receptors in the maternal-fetal ;interface and pathogenesis of unexplained recurrent spontaneous abortion%母胎界面趋化因子及其受体的表达与原因不明复发性流产发病的关系

    张钰; 王建梅; 顾艳; 李奕

    2015-01-01

    Objective To explore the relationship between the expression of chemokines and their receptors in the maternal-fetal interface and the pathogenesis of unexplained recurrent spontaneous abortion (URSA). Methods 8-10 weeks CBA/J female mice were mated with DBA/2 and BALB/c male mice at the ratio of 2∶1 to establish the model of normal pregnant mice (CBA/J × BALB/c) and URSA mice (CBA/J × DBA/2). Sixty mice were divided into 6 groups, with ten in each group. The mice in the normal unpregnancy group were executed for endometrial tissues; the mice in the embryonic implantation normal pregnancy group were executed for endometrial tissues at the sixth day of gestation; the mice in the embryonic development normal pregnancy group were executed for decidua and chorionic tissues at the fourteenth day of gestation. While, the mice in the embryonic implantation URSA group were executed for endometrial tissues at the sixth day of gestation;the mice in the pre-abortion URSA group were executed for decidua and chorionic tissues at the ninth day of gestation;the mice in the post-abortion URSA group were executed for decidua and chorionic tissues at the fourteenth day of gestation. The chemokines and their receptors in different tissues of the mice were determined by western blot, including the protein expression of stromal cell derived factor (CXCL12), monocyte chemotactic protein 1 (CCL2), regulated upon activation normal T cell expressed and secreted(RANTES) and their receptor CXCR4, CCR2, CCR5 in maternal-fetal interface. Results (1) The protein expression of CXCL12 and CXCR4, CCL2 and CCR2, RANTES and CCR5 in endometrial tissues of the normal unpregnant group were 0.13±0.04 and 0.18±0.09, 0.057±0.023 and 0.39± 0.08, 0.034 ± 0.012 and 0.22 ± 0.05, respectively. They were 0.35 ± 0.09 and 0.93 ± 0.15, 0.349 ± 0.056 and 0.91 ± 0.15, 0.336 ± 0.089 and 0.44 ± 0.05 in endometrial tissues in the embryonic implantation normal pregnancy group;and were 0.62±0.15 and 1

  19. 28 CFR 551.23 - Abortion.

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Abortion. 551.23 Section 551.23 Judicial..., Pregnancy, Child Placement, and Abortion § 551.23 Abortion. (a) The inmate has the responsibility to decide either to have an abortion or to bear the child. (b) The Warden shall offer to provide each...

  20. Expression of endothelin-1 and endothelin receptors in villi and its relation to unexplained recurrent spontaneous abortion%ET-1及受体在不明原因复发性流产绒毛中的表达及其对滋养细胞迁移的调节

    周红娣; 宗姗姗; 罗成凤; 王凯; 周倩

    2015-01-01

    目的 通过检测内皮素-1(endothelin-1,ET-1)及受体(endothelin receptors,ETR)在不明原因复发性流产(unexplained recurrent spontaneous abortion,URSA)绒毛组织中的表达,探讨其与URSA的关系.方法 不明原因复发性流产患者30例(RSA组)及正常早孕人流妇女30例(正常组,即CTL组),采用实时荧光定量PCR(Real-Time PCR)及Western印迹法检测两组绒毛组织中ET-1、ETR-A、ETR-B mRNA及蛋白的表达.取体外培养的妊娠早期绒毛外滋养细胞Transwell迁移实验法检测ET-1、ETR-A阻断剂BQ-123及ETR-B阻断剂BQ-788受体对绒毛外滋养细胞迁移能力的影响.结果 RSA组较正常组绒毛组织中ETR-B mRNA及蛋白表达降低,差异有统计学意义(P<0.05),而ET-1、ETR-A mRNA及蛋白在二组绒毛组织中的表达差异无统计学意义(P>0.05).ET-1促进HTR-8细胞迁移,ETR-B阻断剂阻断ET-1的促迁移作用.结论 ET-1可能通过ETR-B受体促进妊娠早期绒毛外滋养细胞迁移,URSA患者较正常组绒毛中ETR-B mRNA及蛋白表达降低可能与URSA相关.

  1. [Umberto Eco and abortion].

    1997-09-01

    The Cardinal of Milan and the linguist and writer Umberto Eco maintained a correspondence in the mid-1990s in connection with the Italian magazine ¿Liberal¿. One of the issues discussed was the conflict between belief in the value of human life and existing abortion legislation. Umberto Eco stated that he would do all in his power to dissuade a woman pregnant with his child from having an abortion, regardless of the personal cost to the parents, because the birth of a child is a miracle. He would not, however, feel capable of imposing his ethical position on anyone else. Terrible moments occur in which women have a right to make autonomous decisions concerning their bodies, their feelings, their futures. Those who disagree cite the right to life, a rather vague concept about which even atheists can be enthusiastic. The moment at which a new human being is formed has been brought to the center of Catholic theology, despite its uncertainty; the beginning of a new life may always need to be understood as a process whose end result is the newborn. Only the mother should decide at what moment the process may be interrupted. The cardinal¿s response distinguished between psychic and physical life, on the one hand, and life participating in the life of God on the other. The threshold is the moment of conception, reflecting a continuity of identity. The new being is worthy of respect. Any violation of the affection and care owed to the being can only be experienced as a profound suffering and painful laceration that may never heal. The response of Eco is unknown.

  2. Motion under graviditeten og risikoen for spontan abort--sekundaerpublikation

    Madsen, Mia; Jørgensen, Tina; Jensen, Mette Lundsby;

    2008-01-01

    We investigated the association between exercise during pregnancy and risk of miscarriage among more than 90,000 pregnant women. Information on exposures was obtained by means of computer-assisted telephone interviews. A relation was found between the amount of exercise and the risk of miscarriag...

  3. Genetic regulation of recurrent spontaneous abortion in humans

    Daniel Vaiman

    2015-02-01

    Full Text Available Recurrent pregnancy loss, defined as a pregnancy failure occurring before 24 weeks of gestation more than two or three times according to most definitions, is a fertility defect encountered in 1-5% of the patients. This defect is of course of multifactorial origin. Among the possible origins of recurrent pregnancy loss are uterine structural defaults, defective ploidy control of the embryo, defective immunological dialog between the embryo (or the fetus and the uterus sometimes in relation with immunological disorders (such as autoimmune diseases, thrombophilia, and free radical metabolism imbalance. Numerous studies attempted to correlate variants of genes supposed to be intervening in the different facets of the early maternal-fetal or maternal-embryonic dialog, and eventually modify the outcome of fertilization, leading to success or failure of post-implantation development. The objective of the present review is to portray the major genes and gene polymorphisms studied for their putative association with recurrent pregnancy loss. Most of these genes have been studied as candidate genes for which strong biological arguments were put forward as to their putative involvement in recurrent pregnancy loss. They were mostly studied by genetic analysis, often in various populations of different ethnic origins, throughout the world. Some of these studies were available only in English as abstracts and were nevertheless used if the information was given with enough detail. With the space being too short to depict all the available literature, different major pathways releva nt to the scientific question are presented without any attempt to hide the fact that discordant views often aroused for a given gene.

  4. Motion under graviditeten og risikoen for spontan abort

    Madsen, Mia; Jørgensen, Tina; Jensen, Mette Lundsby;

    2008-01-01

    We investigated the association between exercise during pregnancy and risk of miscarriage among more than 90,000 pregnant women. Information on exposures was obtained by means of computer-assisted telephone interviews. A relation was found between the amount of exercise and the risk of miscarriag...... with the risk of miscarriage rising stepwise by the amount of exercise performed. Particularly "high impact exercise" was associated with an increased risk of miscarriage. No association was seen between exercise and risk of miscarriage after 18 weeks of gestation....

  5. ISOLATION OF VIRUS IN PRODUCTS OF CONCEPTION IN SPONTANEOUS ABORTION

    KAMYAB S.D. AZARI S.D. NATEGH R

    1980-08-01

    Full Text Available Two hundred pa t ient s o f t he l ow socioe conomic g roup wi th an aborti on o f the f i r s t t r i mest e r were stud 1ed . The s ter i l e produc ts o f concept ion were c ul t ured on Gr e e n Monke y Kidney ti s sue cul t ure f or v i r a l de t e c - tion. Four po s i t i ve Herpe s virus, two positive Rubella"nv~ru s and t hree pos i tive unidentifie d Entero v irus l ike Vlrus were obtained The sera of 192 of these patients were titrated for Rubella antibody. The sera of a control group of 150 normal pregnant women were titrated for Rubella antibody and 8.8 per cent of these patients had a negative titre and 21.3 per cent , 1 had a tltre over 40

  6. Demand for abortion and post abortion care in Ibadan, Nigeria

    2014-01-01

    Background While induced abortion is considered to be illegal and socially unacceptable in Nigeria, it is still practiced by many women in the country. Poor family planning and unsafe abortion practices have daunting effects on maternal health. For instance, Nigeria is on the verge of not meeting the Millennium development goals on maternal health due to high maternal mortality ratio, estimated to be about 630 maternal deaths per 100,000 live births. Recent evidences have shown that a major f...

  7. 原因不明性复发性流产患者Th17/Treg细胞失衡及主动免疫治疗效果%Imbalance of Th17/Treg Cells in Patients with Unexplained Recurrent Spontaneous Abortion and Curative Effect of Lymphocyte Active Im-munotherapy

    郑艳萍; 杨菁

    2015-01-01

    Objective To investigate the proportions of Th17/Treg in the peripheral blood of patients with unexplained recurrent spontaneous abortion ( URSA) and the effect of lymphocyte ac-tive immunotherapy on the balance of Th17/Treg.Methods Flow cytometry was applied to detect the proportion of Th17/Treg in the peripheral blood of 28 URSA patients ( experimental group) and 30 normal early pregnant women ( control group ) .Then changes in Th17/Treg levels were further assessed in URSA patients who received lymphocyte active immunotherapy.The pregnancy outcomes were followed up.Results The proportion of Th17 cells was significantly higher in URSA group than that in control group, while Treg cell proportion was obviously lower in URSA group ( P <0.05 ) .The ratio of Th17/Treg favored a Th17 shift in URSA group ( P<0.05 ) .After immuno-therapy, the proportion of Th17 cells decreased while Treg cells increased.The ratio of Th17/Treg was recognized with a Treg shift.Follow up of pregnancy suggested a success rate of 73.9% in the experimental grop.Conclusion There is an imbalance of Th17/Treg in URSA.Lymphocyte active immunotherapy is effective for URSA by improving the imbalance of Th17/Treg.%目的:探讨原因不明性复发性流产患者外周血中Th17/Treg细胞水平,及淋巴细胞主动免疫治疗对Th17/Treg平衡的影响。方法应用流式细胞术检测28例原因不明性复发性流产( unexplained recurrent spontaneous abortion, URSA)患者和30例正常妊娠早期妇女外周血中Th17/Treg细胞的比例;对自愿接受免疫治疗的23名URSA患者行淋巴细胞主动免疫治疗,检测治疗后患者外周血Th17/Treg水平的变化,并对妊娠结局进行随访。结果 URSA患者外周血中Th17细胞比例显著高于对照组,而Treg细胞比例则明显低于对照组, Th17/Treg的比值较对照组升高( P<0.05);经主动免疫治疗后, Th17细胞比例下降, Treg细胞比例上升, Th17/Treg比

  8. Disturbances of electrodynamic activity affect abortion in human

    Jandová, A.; Nedbalová, M.; Kobilková, J.; Čoček, A.; Dohnalová, A.; Cifra, M.; Pokorný, J.

    2011-12-01

    Biochemical research of biological systems is highly developed, and it has disclosed a spectrum of chemical reactions, genetic processes, and the pathological development of various diseases. The fundamental hypothesis of physical processes in biological systems, in particular of coherent electrically polar vibrations and electromagnetic activity, was formulated by H. Fröhlich he assumed connection of cancer process with degradation of coherent electromagnetic activity. But the questions of cellular structures capable of the coherent electrical polar oscillation, mechanisms of energy supply, and the specific role of the endogenous electromagnetic fields in transport, organisation, interactions, and information transfer remained open. The nature of physical disturbances caused by some diseases (including the recurrent abortion in humans and the cancer) was unknown. We have studied the reasons of recurrent abortions in humans by means of the cell mediated immunity (using immunologic active RNA prepared from blood of inbred laboratory mice strain C3H/H2K, infected with the lactate dehydrogenase elevating virus-LD V) and the cytogenetic examination from karyotype pictures. The recurrent abortion group contained women with dg. spontaneous abortion (n = 24) and the control group was composed of 30 healthy pregnant women. Our hypothesis was related to quality of endometrium in relation to nidation of the blastocyst. The energetic insufficiency (ATP) inhibits normal development of fetus and placenta. We hope that these ideas might have impact on further research, which could provide background for effective interdisciplinary cooperation of malignant and non-malignant diseases.

  9. The Development of Instruments to Measure Attitudes toward Abortion and Knowledge of Abortion

    Snegroff, Stanley

    1976-01-01

    This study developed an abortion attitude scale and abortion knowledge inventory that may be utilized by health educators, counselors, and researchers for assessing attitudes toward abortion and knowledge about it. (SK)

  10. 复发性流产患者家庭功能及应对方式与心理状况的相关性研究%Correlation study on family functioning and coping style with mental health in recurrent spontaneous abortion patients

    龚桂芳; 曾晓琴; 肖青; 林艳

    2015-01-01

    目的:调查复发性流产(RSA)患者的心理状况,探讨其家庭功能及应对方式与心理状况的相关性。方法选取2013年9—12月 RSA 患者及普通女性各115例作为研究组及对照组,采用家庭功能评定量表、医学应对方式问卷及症状自评量表(SCL-90)对其进行调查,用 SPSS 13.0统计软件分析三者之间的关系。结果研究组患者躯体化情况、强迫症状、人际关系敏感、抑郁、焦虑、敌对、恐怖、偏执、精神病性及 SCL-90总分分别为(1.41±0.44),(1.48±0.49),(1.24±0.35),(1.36±0.43),(1.34±0.45),(1.40±0.46),(1.23±0.37),(1.17±0.28),(1.20±0.27),(119.55±31.37)分,均高于对照组,差异有统计学意义(t 值分别为5.14,4.37,2.95,2.99,3.43,4.37,3.27,2.61,3.17,4.24;P <0.05)。研究组患者家庭功能中问题解决、沟通、角色、行为控制及总的功能得分低于对照组,差异有统计学意义(t 值分别为3.58,2.81,2.45,2.16,2.81;P <0.05)。更倾向于采取屈服消极应对方式( t =3.08,P <0.01)。研究组患者家庭功能各因子问题解决、沟通、角色、情感反应、情感介入、行为控制、总的功能与个体的消极应对方式中的屈服均呈正相关( r 值分别为0.12,0.12,0.12,0.11,0.14,0.13,0.12;P <0.05),与积极应对方式面对、回避无相关性(P >0.05)。多元回归分析表明,夫妻关系及自然流产次数是影响 RSA 患者心理健康状况的主要因素。结论 RSA 患者心理健康状况较差,医务人员应采取有效的护理措施提高患者的心理健康状况,促进其采取积极的方式应对困难。%Objective To assess the psychological status of recurrent spontaneous abortion( RSA) patients and analyze the correlation among family functioning,coping style and mental health. Methods A total of 115 RSA patients and

  11. Chlamydia trachomatis in Women with Ful-Term Deliveries and Women with Abortion

    Abdolreza S. Jahromi

    2010-01-01

    Full Text Available Problem statement: There are some documents which support the role of some certain infections such as Chlamydia trachomatis in spontaneous abortion. As there were not data about role this bacterium in abortion in this area of IRAN, this study was conducted to evaluate the prevalence of Chlamydia trachomatis in women with abortion and compare it with healthy women with no previous history of abortion. Approach: This case-control study was carried out in Shariatee hospital of Hormozgan University of medical sciences, during 2004-2005. A number of 220 women with definite diagnosis of previous abortion and 200 matched women with normal full term delivery and negative history of miscarriage as controls were studied as case and control groups. All obtained PAP smears from the case and the control groups were then tested using Immunoflourescent method for detection of Chlamydia trachomatis. Data was analyzed, using SPSS software (chi square and t-test. Results: The prevalence of positive direct immunofluorescent test on PAP smears indicating the presence of Chlamydia trachomatis was 56 (25.45% in women with abortion comparing to 13 (5.20% in women in control group, the difference was significant (p = 0.0001. Conclusion: This study showed Chlamydia trachomatis is an important causative agent for abortion in this area of IRAN.

  12. Maternal and perinatal outcome in women with threatened abortion in first trimester

    Meenal S. Sarmalkar

    2016-05-01

    Conclusions: Pregnant women with first trimester threatened abortion are at increased risk for spontaneous loss and adverse pregnancy outcomes. Knowledge of these risks may help the obstetricians to manage these cases vigorously in the antepartum period and do timely interventions as needed for a healthy mother and baby. [Int J Reprod Contracept Obstet Gynecol 2016; 5(5.000: 1438-1445

  13. Safe abortion: a woman's right.

    Sangala, Vanessa

    2005-07-01

    Complications of induced abortion sadly remain significant causes of maternal mortality and morbidity around the world, but only in countries that do not provide access to safe abortion services. This article presents a brief account of how high maternal mortality from induced abortion became history in the UK and the dire consequences to women's health that unsafe abortion still has in many countries of the world. It gives a brief overview of the methods available to evacuate the uterus, with particular reference to manual vacuum aspiration. The status of the law in different countries is discussed, together with the need for health professionals to interpret repressive laws in ways that enables them to care for women who seek their help. Safe abortion services are cost effective, essential services for women. Men are part and parcel of the reason women resort to terminating a pregnancy, and, together with the countless children whose lives are dependent on a healthy caring mother, are also beneficiaries of safe abortion services. There can be no excuse for continuing to deny these services to so many women around the world.

  14. Contraception and abortion in Romania.

    Johnson, B R; Horga, M; Andronache, L

    1993-04-03

    After the downfall of the Ceausescu regime in December, 1989, the new Government of Romania abolished the law that prohibited abortions on request. Subsequently, the rate of legally induced abortions increased significantly while the rate of maternal mortality declined dramatically. Despite the large number of women who request induced abortions, most women and gynaecologists say that they would prefer to prevent unwanted pregnancies through the use of modern contraception. In this paper we examine factors that contribute to the disparity between women's desire to use modern contraception to prevent unwanted pregnancies and their practice of having induced abortions to prevent unwanted births. The results show that women (and suggest that men) need a wide choice of dependably available high-quality contraceptives; they need to be able to obtain information, counselling, and methods from a wide range of sources/health-care providers; both women's and men's perceptions about, and use of, modern contraception could be positively affected through sexual education started in secondary school; and, to reduce repeat abortions, women's post-abortion family-planning needs must not be neglected.

  15. 中药预防自然流产的研究进展%Research progress on prevention and treatment of natural abortion with traditional Chinese medicine

    王平; 刘善新; 孙铁锋; 王杰

    2015-01-01

    Western medicine considers that abortion related to genetic factors,maternal factors,immunefactors and other factors. Traditional Chinese medicine believes that the kidney is the most fundamental factors of abortion. This paper gave a review of spontaneous abortion mainly from natural abortion pathogenesis,treatment,and prevention methods,which provided a direction for traditional Chinese medicine in the treatment of spontaneous abortion.%西医认为自然流产多与遗传因素、母体因素、免疫因素以及其他因素有关。中医认为肾虚是流产最根本的因素。本文主要从自然流产的发病机制、治疗方法以及防护方法进行阐述,为开发中医中药治疗自然流产提供方向。

  16. Spontaneous Recovery

    Rescorla, Robert A.

    2004-01-01

    Spontaneous recovery from extinction is one of the most basic phenomena of Pavlovian conditioning. Although it can be studied by using a variety of designs, some procedures are better than others for identifying the involvement of underlying learning processes. A wide range of different learning mechanisms has been suggested as being engaged by…

  17. Spontaneous deregulation

    Edelman, Benjamin; Geradin, Damien

    2016-01-01

    Platform businesses such as Airbnb and Uber have risen to success partly by sidestepping laws and regulations that encumber their traditional competitors. Such rule flouting is what the authors call “spontaneous private deregulation,” and it’s happening in a growing number of industries. The authors

  18. Virtue theory and abortion.

    Hursthouse, Rosalind

    1991-01-01

    The sort of ethical theory derived from Aristotle, variously described as virtue ethics, virtue-based ethics, or neo-Aristotelianism, is becoming better known, and is now quite widely recognized as at least a possible rival to deontological and utilitarian theories. With recognition has come criticism, of varying quality. In this article I shall discuss nine separate criticisms that I have frequently encountered, most of which seem to me to betray an inadequate grasp either of the structure of virtue theory or of what would be involved in thinking about a real moral issue in its terms. In the first half I aim particularly to secure an understanding that will reveal that many of these criticisms are simply misplaced, and to articulate what I take to be the major criticism of virtue theory. I reject this criticism, but do not claim that it is necessarily misplaced. In the second half I aim to deepen that understanding and highlight the issues raised by the criticisms by illustrating what the theory looks like when it is applied to a particular issue, in this case, abortion.

  19. Spontaneous Live Twin Tubal Ectopic Pregnancy: A Case Report

    R Benn

    2016-02-01

    Full Text Available We report the case of a 29-year old G3P1+1 woman with a spontaneously conceived live twin tubal ectopic pregnancy. Her history was significant for infertility for 11 years after an induced abortion. Pelvic ultrasound scan showed live twin ectopic pregnancy and a partial salpingectomy was done.

  20. [Readers' position against induced abortion].

    1981-08-25

    Replies to the request by the Journal of Nursing on readers' positions against induced abortion indicate there is a definite personal position against induced abortion and the assistance in this procedure. Some writers expressed an emotional "no" against induced abortion. Many quoted arguments from the literature, such as a medical dictionary definition as "a premeditated criminally induced abortion." The largest group of writers quoted from the Bible, the tenor always being: "God made man, he made us with his hands; we have no right to make the decision." People with other philosophies also objected. Theosophical viewpoint considers reincarnation and the law of cause and effect (karma). This philosophy holds that induced abortion impedes the appearance of a reincarnated being. The fundamental question in the abortion problem is, "can the fetus be considered a human life?" The German anatomist Professor E. Bleckschmidt points out that from conception there is human life, hence the fertilized cell can only develop into a human being and is not merely a piece of tissue. Professional nursing interpretation is that nursing action directed towards killing of a human being (unborn child) is against the nature and the essence of the nursing profession. A different opinion states that a nurse cares for patients who have decided for the operation. The nurse doesn't judge but respects the individual's decision. Some proabortion viewpoints considered the endangering of the mother's life by the unborn child, and the case of rape. With the arguments against abortion the question arises how to help the woman with unwanted pregnancy. Psychological counseling is emphasized as well as responsible and careful assistance. Referral to the Society for Protection of the Unborn Child (VBOK) is considered as well as other agencies. Further reader comments on this subject are solicited.

  1. Polish parliament liberalizes abortion law.

    1996-11-22

    On October 24, the Sejm (Poland's lower house of parliament) voted 228 to 195 (with 16 abstentions) to amend Poland's March 1993 ban on abortions. The amendment legalizes abortion until the 12th week of pregnancy for women who face financial hardship or difficult personal circumstances. Client counseling by a doctor who will not perform the abortion and a 3-day wait are required. Abortions will be permitted in licensed private clinics, as well as in public hospitals. Anyone performing an illegal abortion can receive 2 years' imprisonment. The government will subsidize contraceptive pills, and a sex education curriculum will be developed for schools. Abortion had been legal and widely available under communist rule; however, a Catholic-aligned government limited abortion to cases where a woman's life or health was endangered, where the pregnancy resulted from rape or incest, or where the fetus had a severe anomaly. The Catholic Church opposed the new measure, and the Senat (Poland's upper house), on October 3, had voted 40 to 52 (with 2 abstentions) against the amendment. Although the Sejm had previously voted 208 to 61 (with 15 abstentions) in favor of the amendment, 120 of those opposed to the measure, primarily members of the Polish Peasants Party (part of Poland's ruling coalition), had walked out in protest just before an August tally. The Democratic Left Alliance, the other coalition partner, supports the amendment. The most recent vote in the Sejm overturns the Senat veto; however, before the law can go into effect in 1997, it must be signed by President Aleksandr Kwasniewski (a supporter) after a review by Poland's conservative constitutional tribunal.

  2. [Induced abortion in China: problems and interventions].

    Wu, Shang-chun; Qiu, Hong-yan

    2010-10-01

    Pooled literatures showed that the induced abortion in China faces many problems:the number of induced abortion remains large; most cases are young and nulliparity women; the frequency of abortion is high; and the interval between one and another abortion is short. Health promotion strategies should be applied to address these problems. It is important to increase the population's awareness of contraception,especially among nulliparity and migrant populations. Routine and effective contraceptive methods should be recommended and emphasized during induced abortion and delivery to lower the rate of induced abortion.

  3. Abortion applicants in Arkansas.

    Henker, F O

    1973-03-01

    The article reports upon the characteristics of 300 abortion applicants in Arkansas manifesting significant stress from unwanted pregnancy between May 1, 1970 and June 30, 1971. The sample is limited by the fact that all of these women had been willing to seek medical aid. Patients ranged from ages 13-47, 131 of them ages 17-21. 35% had had some college education; another 29% were high school graduates. 50.6%, 20.6%, and 27.3% were single, divorced, and married, respectively. 59.6% of the patients were primiparas. 18.3%, 9.6%, and 12.3% were classified as being neurotic, having psychophysiologic tendencies (gastrointestinal problems, obesity, chronic headaches), and having sociopathic features (passive-aggressive, frankly rebellious, delinquent, antisocial, alcoholic), respectively. 12 women had noticeable schizoid features; 4 women had mildly active schizophrenia. Fathers of the women were usually blue-collar workers (55.3%) or white-collar workers (24.6%). The most frequent ordinal sibling position among the women was oldest child (38%). Parental instability (1 or both parents lost through death, divorce, father usually away working, chronic alcoholism, etc.) was reported by 39.6% of the patients. Patients' attitudes toward the unwanted pregnancy included dislike of inexpediency of the situation (82.6%), self-depreciation (55.6%), and aversion (28.6%). Precipitated psychiatric disorders were for the greatest part mild. Manifesting symptoms included depression (66.7%), anxiety (21%), and mixed anxiety and depression (12.2%). Suicidal threats and gestures were made by 22 and 8 patients, respectively. In summary, the study reveals a group of predominantly Caucasian women from unstable, middle-class urban families who were going through an adjustment reaction to adolescence or adult life.

  4. Abortion and the law: the Supreme Court, privacy, and abortion.

    Marsh, F H

    1997-01-01

    This article examines the impact of the continuing politicization of the abortion issue in the US on the rights of women and on the emerging concept of fetal rights. The introduction 1) attributes the "final and total politicization" of a woman's right to control her reproduction to the "undue burden" standard introduced by the Supreme Court in its 1992 Casey decision and 2) claims that, if unchecked, the concept of fetal rights may give the state's interest in protecting potential life supremacy over women's rights. The next section presents an in-depth discussion of the politicization of the right to abortion that covers such topics as how the courts before Casey became the forum for debating abortion policy, how the "undue burden" standard fails to set definite parameters of acceptable state behavior, how the Casey decision in effect abandons the trimester-based framework of reference provided in Roe vs. Wade, how Casey allows states to subtly coerce women seeking abortions, how the Casey decision failed to reduce the intense politicization of abortion, and how the court failed to protect individual rights to health care and abortion funding from states. Part 3 of the article begins its exploration of the concept of "fetal rights" with a sketch of the history of this concept in the US courts starting in 1884 when damages for miscarriage were denied. Ways in which fetal rights compete with the rights of a pregnant woman are described, the Supreme Court is blamed for allowing states to develop this concept, and issues of patient confidentiality versus reporting requirements are considered. It is concluded that the Supreme Court will have to act to limit fetal rights.

  5. Global consequences of unsafe abortion.

    Singh, Susheela

    2010-11-01

    Unsafe abortion is a significant cause of death and ill health in women in the developing world. A substantial body of research on these consequences exists, although studies are of variable quality. However, unsafe abortion has a number of other significant consequences that are much less widely recognized. These include the economic consequences, the immediate costs of providing medical care for abortion-related complications, the costs of medical care for longer-term health consequences, lost productivity to the country, the impact on families and the community, and the social consequences that affect women and families. This article will review the scientific evidence on the consequences of unsafe abortion, highlight gaps in the evidence base, suggest areas where future research efforts are needed, and speculate on the future situation regarding consequences and evidence over the next 5-10 years. The information provided is useful and timely given the current heightened interest in the issue of unsafe abortion, growing from the recent focus of national and international agencies on reducing maternal mortality by 75% by 2015 (as one of the Millennium Development Goals established in 2000).

  6. Abortion laws into action: implementing legal reform.

    Gerhardt, A J

    1997-01-01

    The worldwide trend towards liberalizing abortion laws has resulted in reduced abortion-related mortality in areas where legal abortion is accessible. In countries considering abortion reform, policy-makers and health care providers have a responsibility to ensure that provisions of any new law can be met. Preparations underway to prepare for South Africa's new abortion law can serve as a guideline for such action. A new abortion law calls for policy changes that may include 1) developing new standards, protocols, and guidelines for abortion care services; 2) ensuring provision of adequate trained staff willing to provide abortions; 3) streamlining administrative regulations to avoid delays; 4) establishing regulations and mechanisms for drug and equipment supply and distribution; 5) restructuring the health system to accommodate provision of abortion services; 6) allocating funds for new abortion services; and 7) reviewing and revising security measures. In addition, health professionals will require training in abortion provision, staff will need information updates about aspects of the legislation, and administrators and providers in a position to impede provision of services must be made aware of the affect of unsafe abortion on maternal health. Researchers should document the effect of the new law on women's health, the provision of reproductive health services, and the community. IEC (information, education, communication) activities will be required to inform the public about the new law and services, establish sex education programs in schools and health facilities, and mobilize family planning organizations and programs to help reduce the incidence of repeat abortions.

  7. The skewed usage of T cell receptor β variable chain at the maternal-fetal interface of women with unexplained recurrent spontaneous abortion%原因不明复发性流产患者母-胎界面T淋巴细胞受体β链可变区基因的表达水平和频率

    汪希鹏; 林其德; 马政文; 洪艳; 陆佩华

    2008-01-01

    Objective To investigate T cell receptor(TCR)variable β(BV)chain usage at the maternal-fetal interface and explore the relationship between the skewed TCR BV usage and unexplained recurrent spontaneous abortion(BSA).Methods Eighteen cases with unexplained RSA,together with matched 41 women with normal pregnancies in first trimester from Renji Hospital,Shanghai Jiao Tong University were studied.A high-resolution spectrum typing analysis of complementarity-determining region 3 (CDR3)was used to detect and compare the degree and frequency of TCR BV family expression in deciduas between RSA patients and normal controls.Results(1)The expression degree of BV19(0.029±0.031 vs.0.013±0.010,P=0.038)in RSA group showed a higher usage,while BV5.2(0.040±0.035 vs.0.067±0.052,P=0.046)showed a significantly lower usage when compared with normal controls.No significant difference in the expression of the other TCR BV families between RSA and controls were observed(P>0.05).(2),TCR BV2,3,6,and 7 were the four most common BV families in deciduas of patients with RSA and normal controls,whose frequencies were all mors than 50%.In RSA group,higher frequencies of BV15 (33.3%vs.7.3%,P=0.018),BV19(38.9%vs.14.6%,P=0.049)and BV20(33.3%vs.7.3%,P=0.018)were observed;meanuhile lower frequencies of BV4(33.3%vs.65.9%,P=0.026)and BV7 (66.7%vs.92.7%.P=0.018)distributions were observed.The other TCR BV families did not display significantly different freqencies of distribution(P>0.05).Conclusions It is suggested that a significant skewed TCR BV family occurs at the maternal-fetal interface in patients who undergo abortion.The specific skewed usages of TCR BV might be associated with the susceptibility to unexplained pregnancy loss.%目的 通过分析母-胎界面T淋巴细胞受体(TCR)β链可变区(BV)基因的表达水平和频率,探索T淋巴细胞参与原因不明复发性流产(RSA)发生的作用机制.方法 采集18例原因不明RSA患者(研究组)和4l例正常早孕人工流产

  8. 微阵列比较基因组杂交技术在自然流产遗传学分析中的应用%Application of array-based comparative genomic hybridization technique in genetic analysis of ;patients with spontaneous abortion

    楚艳; 吴东; 侯巧芳; 霍晓东; 高越; 王涛; 王红丹; 杨艳丽; 廖世秀

    2016-01-01

    目的:探讨微阵列比较基因组杂交(array-CGH)技术在自然流产组织染色体分析中的应用,为自然流产的遗传咨询和临床诊治提供指导。方法选取2013年11月至2016年1月在河南省人民医院就诊的自然流产患者382例,收集流产绒毛或胎儿组织,采用array-CGH技术对流产绒毛或胎儿组织的全基因组拷贝数进行检测,并同时行细胞培养和传统G显带染色体核型分析,比较G显带染色体核型分析及array-CGH的结果。结果 array-CGH技术成功获得结果382例,检测成功率为100.0%(382/382),染色体异常检出率为46.6%(178/382);染色体核型分析技术成功获得结果281例,检测成功率为73.6%(281/382),染色体异常检出率为40.2%(113/281);array-CGH均高于染色体核型分析技术。array-CGH检测出的178例染色体异常中,染色体数目异常163例(91.6%,163/178);染色体结构异常15例(8.4%,15/178),其中10例同时出现了染色体微重复和微缺失的流产胚胎中有4例被证实父母一方为染色体平衡易位携带者。染色体核型分析检出的113例染色体异常中,染色体数目异常108例(95.6%,108/113),染色体结构异常5例(4.4%,5/113)。两种方法的结果不一致有3例,其中2例为三倍体、1例为性染色体低比例嵌合,array-CGH均漏检为正常。结论 array-CGH技术用于自然流产胚胎组织的染色体分析成功率高,对标本的取材要求远低于传统染色体核型分析技术,且分辨率高、准确快速,可以作为流产组织遗传学诊断的一线技术。%Objective To investigate the value of array-based comparative genomic hybridization (array-CGH) technique for the detection of chromosomal analysis of miscarried embryo, and to provide genetic counseling for couples with spontaneous abortion. Methods Totally 382 patients who underwent miscarriage were enrolled in this study. All

  9. To abort or not to abort: that is the question.

    Thomison, J B

    1991-02-01

    Abortion is not a medical issue, as the law would like to make it when requesting definitions of when life begins. To medicine, life begins at conception. conception is the 1st step in the miracle of life. It is up to the law and society to determine when life begins legally. Doctors have responsibilities as citizens to do what they can to support laws they believe in. The American Medical Association has remained neutral on the issue. Abortion can be ethical if the mother's life is threatened. But it is unethical and unconstitutional when it is done out of convenience to correct indiscretions.

  10. 补肾安胎冲剂对复发性自然流产小鼠蜕膜组织超微结构的影响%Effects of Granules for Tonifying the Kidney and Preventing Miscarriage on Ultrastructure of Decidual Tissue in Mice with Recurrent Spontaneous Abortion

    李伟莉; 杨璇; 李肖凤

    2015-01-01

    目的 观察补肾安胎冲剂对复发性自然流产(recurrent spontaneous abortion,RSA)小鼠蜕膜组织血管、细胞形态及血管内皮细胞超微结构的影响.方法 采用DBA/2×CBA小鼠,按照Clark经典方法复制RSA小鼠模型.按妊娠顺序将小鼠随机分为正常妊娠组,模型组,西药组,补肾安胎冲剂高、中、低剂量组,每组10只,分别进行药物干预.光镜下观察蜕膜组织的血管和细胞形态,电镜下观察血管内皮细胞超微结构.结果 光镜下见模型组血管数量减少,蜕膜细胞胞浆明显水肿,部分核消失,细胞核固缩;补肾安胎冲剂高剂量组血管丰富且管壁完整,由多个血管内皮细胞环绕而成,小部分蜕膜细胞水肿,细胞核基本无坏死;补肾安胎冲剂中、低剂量组血管数量少于补肾安胎冲剂高剂量组,血管内皮细胞排列不整齐,部分蜕膜细胞胞浆水肿,空泡变,少数细胞核消失.电镜下见模型组血管壁不完整,血管内皮细胞结构不完整,细胞核呈梭形,粗面内质网、核糖体减少,部分线粒体已破坏;补肾安胎冲剂高剂量组血管壁完整,血管内皮细胞结构完整,核膜完整;胞浆中可见丰富粗面内质网及核糖体,线粒体结构完整、无肿胀变性,染色质分布均匀;补肾安胎冲剂中、低剂量组血管壁完整,部分血管内皮细胞肿胀,核膜完整,胞浆中粗面内质网扩张,核糖体轻度减少,部分线粒体肿胀、空泡变.结论 RSA模型小鼠存在母胎界面血管生成的障碍,补肾安胎冲剂可以修复RSA小鼠蜕膜组织中破坏的细胞结构,改善血管生成和细胞器完整度,发挥安胎作用.

  11. Impact of Shoutai pills on Th17/Treg in patients with recurrent spontaneous abortion%寿胎丸治疗对反复自然流产患者Th17/Treg细胞表达水平的影响

    幸彩梅; 钟菊珍; 范世珍; 吴莉莉; 张明霞

    2013-01-01

    目的 探讨寿胎丸治疗对反复自然流产(RSA)患者调节性T细胞(Treg)和辅助性T细胞17(Th17)表达水平的影响.方法 流式细胞术检测20例RSA患者寿胎丸治疗前及治疗1、3个月后外周血Th17、Treg细胞表达水平,以26例健康孕妇作为对照组.结果 RSA患者Th17细胞表达水平显著升高(P<0.05),Treg表达水平显著降低(P<0.05).治疗3个月后,RSA患者Th17细胞数量降低(P<0.05),Treg细胞数量升高(P<0.05);治疗前Th17/Treg比值高于对照组(P<0.05),治疗后逐渐降低,3个月后恢复至正常水平.结论 Th17和Treg细胞参与了RSA免疫应答,Th17/Treg细胞平衡在维持妊娠中发挥重要作用.寿胎丸可有效改善RSA患者Th17/Treg细胞失衡.%Objective To explore the impact of Soutai pills on expression levels of regulatory T lymphocyte and T helper lymphocyte 17(Th17) in patients with recurrent spontaneous abortion(RSA).Methods Flow cytometry analysis were used to evaluate expression levels of Treg and Th17 cells in peripheral blood from 20 RSA patients,before and 1,3 months after treatment of Soutai pills.26 healthy pregnant women were enrolled and control group.Results The frequency of Th17 cells in RSA group was significantly higher than that in control group(P<0.05).The frequency of Treg cells was significantly lower in RSA patients than that in control group(P<0.05).After 3 months of treatment with Shoutai pills, the number of Th17 cells were reduced(P<0.05) and Treg cells were significantly increased(P<0.05).The ratio of Th17/Treg was higher than that in control group(P<0.05).After 3 months of treatment,it returned to normal levels.Conclusion Th17 and Treg cells might participate in immune response of RAS, and the imbalance of Th17/Treg cells could play an important role in RSA.Th17/Treg cell imbalance could be improved after effective treatment with Shoutai pills.

  12. Locus of control and decision to abort.

    Dixon, P N; Strano, D A; Willingham, W

    1984-04-01

    The relationship of locus of control to deciding on an abortion was investigated by administering Rotter's Locus of Control Scale to 118 women immediately prior to abortion and 2 weeks and 3 months following abortion. Subjects' scores were compared across the 3 time periods, and the abortion group's pretest scores were compared with those of a nonpregnant control, group. As hypothesized, the aborting group scored significantly more internal than the general population but no differences in locus of control were found across the 3 time period. The length of delay in deciding to abort an unwanted pregnancy following confirmation was also assessed. Women seeking 1st trimester abortions were divided into internal and external groups on the Rotter Scale and the lengths of delay were compared. The hypothesis that external scores would delay the decision longer than internal ones was confirmed. The results confirm characteristics of the locus of control construct and add information about personality characteristics of women undergoing abortion.

  13. Abortion Counseling and the School Counselor

    Duncan, Jack A.; Moffett, Catherine F.

    1974-01-01

    Abortion counseling is now legally within the purview of the school counselor. It is therefore essential that counselors determine their role in abortion counseling, the kind of training necessary, and whether professional organizations should develop counseling guidelines. (RP)

  14. Abortions: Does It Affect Subsequent Pregnancies?

    Healthy Lifestyle Getting pregnant Could an abortion increase the risk of problems in a subsequent pregnancy? Answers from Roger W. Harms, M.D. Generally, abortion isn't thought to cause fertility issues or ...

  15. Adolescent abortions: Situational analysis based on official statistics conducted in Kazakhstan during the last 5 years (2007-2011

    Gulya Nazarovna Alimbayeva

    2013-10-01

    Full Text Available In recent decades, adolescent pregnancy has become an important health issue in a great number of both developed and developing countries.We have investigated the official statistics database of the National Ministry of the Health (MoH and their #13 Statutory Form (SF and found the total number of abortions between 2007-2011 in Kazakhstan decreased by 28%. The total number of adolescent (≤15 and 15-18 years of age abortions decreased by 52.7%. Contrary to this decrease in the total number of adolescent abortions, spontaneous abortions have increased from 23.2% to 45.0%. We found a tendency towards a decrease in the number of adolescents with the first pregnancy among adolescents 15-18 who had abortion between 2007-2011, from 51.3% to 35.8%. This clearly reflects the success of prevention activities among adolescents who have already had an abortion or birth. During the analyzed period, there were two lethal outcomes from abortions among girls 15-18 years old. There are some limitations in the assessment levels and dynamic changes of abortions among adolescents due to the division of age in the official statistical database.

  16. Abortion in Brazil: A Search For Rights

    Anjos, Karla Ferraz dos; Universidade Estadual do Sudoeste da Bahia; Santos, Vanessa Cruz; Universidade Estadual do Sudoeste da Bahia; Souzas, Raquel; Universidade Federal da Bahia; Eugênio, Benedito Gonçalves; Universidade Estadual do Sudoeste da Bahia

    2013-01-01

    Discussing the abortion theme in Brazil is highly problematic since it involves ethical, moral and legal precepts. The criminalization of abortion in Brazil favors a clandestine and unsafe practice and can lead to serious consequences to women´s health. In this perspective, this research deals with the legal context in which the abortion problem is inscribed in Brazil, coupled to the specific aims in pinpointing complications caused by the criminalization of clandestine abortion besides deali...

  17. Molecular Testing for Toxoplasma Diagnosis in Aborted Fetuses- Taleghani Maternity Hospital- Arak- Iran

    Zahra Eslamirad

    2014-08-01

    Full Text Available Background: The diagnosis of toxoplasmosis is most critical in pregnant women who acquire infection during gestation and also in fetuses and newborns who are congenitally infected. This study described the performance of molecular and confirmatory serologic testing for toxoplasma infection in the tissues of human spontaneous aborted fetuses and their mothers' blood. Materials and Methods: 87 random samples from the tissues of body of spontaneous aborted fetuses (less than 14 weeks in a separate container of preservative solution were collected from the delivery room of the university maternity hospital, Arak- Iran , during autumn 2012 to 2013. In the ward, 3 ml of blood sample of their mothers were collected and the sera were separated and analyzed by ELISA method for the detection of specific IgG. DNA extraction from the tissues of fetuses was performed and stored until use. The PCR reaction was performed by a pair of primers. PCR products were analyzed by electrophoresis and stained with safe stain. It is necessary to mention first that the written consent was obtained from their mothers and after recovery, a demographic questionnaire was completed. Results: Most of the mothers were 20-29 years of age and the correlation between the location of residence, contact with cats and eating undercooked food with abortion, not significant. Serological tests on the sera of 87 mothers for anti-Toxoplasma IgG showed 39.08% positive results. The results of PCR amplification showed that none of the 87 samples from aborted fetuses were infected with Toxoplasma gondii. Conclusion: In aborted fetuses, we did not observe any evidence of Toxoplasmosis and it appears that Toxoplasma gondii was not the cause of spontaneous abortion in this area of Iran but considering the importance of the infection during pregnancy, the control measurements during pregnancy is required.

  18. Abortion and Mental Health: Evaluating the Evidence

    Major, Brenda; Appelbaum, Mark; Beckman, Linda; Dutton, Mary Ann; Russo, Nancy Felipe; West, Carolyn

    2009-01-01

    The authors evaluated empirical research addressing the relationship between induced abortion and women's mental health. Two issues were addressed: (a) the relative risks associated with abortion compared with the risks associated with its alternatives and (b) sources of variability in women's responses following abortion. This article reflects…

  19. Prevalence of Abortion and Contraceptive Practice among Women Seeking Repeat Induced Abortion in Western Nigeria

    2015-01-01

    Background. Induced abortion contributes significantly to maternal mortality in developing countries yet women still seek repeat induced abortion in spite of availability of contraceptive services. The aim of this study is to determine the rate of abortion and contraceptive use among women seeking repeat induced abortion in Western Nigeria. Method. A prospective cross-sectional study utilizing self-administered questionnaires was administered to women seeking abortion in private hospitals/cli...

  20. Abortion, infanticide and moral context.

    Porter, Lindsey

    2013-05-01

    In 'After-birth abortion: why should the baby live?', Giubilini and Minerva argue that infanticide should be permitted for the same reasons as abortion. In particular, they argue that infanticide should be permitted even for reasons that do not primarily serve the interests (or would-be best interests) of the newborn. They claim that abortion is permissible for reasons that do not primarily serve the interests (or would-be interests) of the fetus because fetuses lack a right to life. They argue that newborns also lack a right to life, and they conclude that therefore, the same reasons that justify abortion can justify infanticide. This conclusion does not follow. The lack of a right to life is not decisive. Furthermore, the justificatory power of a given reason is a function of moral context. Generalisations about reasons across dissimilar moral contexts are invalid. However, a similar conclusion does follow-that fetus-killing and newborn-killing are morally identical in identical moral contexts-but this conclusion is trivial, since fetuses and newborns are never in identical moral contexts.

  1. Free abortion has come to stay.

    1991-01-01

    In Sweden abortion has been free and on demand since 1975. The philosophy behind this law is that the pregnant women is the best judge of whether she should have an abortion. Any attempt to change the legal status of abortion should be strongly fought. Criminalizing abortion has never amounted to any good in any country that has tried it. A critical aspect of abortion is that it must be prevented with effective sexual education and free access to contraception. This is the best way to avoid unwanted pregnancies and thus abortion. Still even in Sweden 25% of all pregnancies end in abortion. Planned parenthood is essential in a country with a high standard of living in order to maintain an adequate level of births. Many countries with high standards of living have very low births rates because they do not offer parental leave, short working hours, or day care.

  2. Mental health and abortion: review and analysis.

    Ney, P G; Wickett, A R

    1989-11-01

    This survey of studies which relate to the emotional sequelae of induced abortion, draws attention to the need for more long-term, in-depth prospective studies. The literature to this point finds no psychiatric indications for abortion, and no satisfactory evidence that abortion improves the psychological state of those not mentally ill; abortion is contra-indicated when psychiatric disease is present, as mental ill-health has been shown to be worsened by abortion. Recent studies are turning up an alarming rate of post-abortion complications such as P.I.D., and subsequent infertility. The emotional impact of these complications needs to be studied. Other considerations looked at are the long-term demographic implications of abortion on demand and the effect on the medical professions.

  3. Abortion--the breath of life.

    Joling, R J

    1974-01-01

    A scholarly review of medical-legal and biblical authority on the su bject of abortion supports abortion as a woman's right when it is performed before the fetus has had its "breath of life." Based on biblical evidence, a person becomes a living being when the soul, the "breath of life" is breathed into it. Without the "breath of life" no person exists. A fetus less than 28 weeks old is incapable of breathing alone; thus an aborted fetus that age is not truly a living human being capable of surviving independently of its mother's womb. Legal aspects include supreme, local and state court decisions defining abortion. It is ultimately expected that each person will determine what approach to take towards the abortion question. Abortion is still a personal problem regardless of supreme court decisions or ecclesiastical determinants. Religion and moral concepts should be the guiding conscience involved in the question of abortion.

  4. Human Papillomavirus Infection as a Possible Cause of Spontaneous Abortion and Spontaneous Preterm Delivery

    Ambühl, Lea Maria Margareta; Baandrup, Ulrik; Dybkær, Karen;

    2016-01-01

    Based on the current literature, we aimed to provide an overview on Human Papillomavirus prevalence in normal pregnancies and pregnancies with adverse outcome. We conducted a systematic literature search in PubMed and Embase. Data extracted from the articles and used for analysis included HPV pre...

  5. Induced abortion--a global health problem.

    Odlind, V

    1997-01-01

    Every year around 500,000 women are estimated to die from pregnancy-related causes, the majority in the developing world and many as a consequence of unsafe abortion. Around 25 per cent of maternal deaths in Asia and 30-50 per cent of maternal deaths in Africa and Latin America occur as a result of induced abortion. Data on abortion related maternal morbidity is less reliable than mortality but suggests that for every maternal death 10-15 women suffer significant pregnancy-related morbidity, i.e. infertility, genito-urinary problems and/or chronic pain. Induced abortion occurs in practically every society in the world but only 40 per cent of the women in the world live in countries where abortion is legally free. A permissive legislation is an important prerequisite for medically safe and early abortion. Oppositely, with a restrictive law, abortion is difficult to obtain, costly and possibly unsafe, in particular to the least affluent women in the society. Induced abortion in a developed country with legal and easy access to services is a safe procedure with hardly any mortality and very low morbidity. The best strategy to reduce the number of unsafe abortions is prevention of unwanted pregnancy. The consequences of unsafe abortion on women's health need to be acknowledged by everybody in the society in order to improve abortion care. It is necessary to adjust legal and other barriers to medically safe abortion in order to follow the declaration at the UN conference on population in Cairo, 1994, which stated that abortion, wherever legal, should be safe. It is also necessary to introduce preventive measures where abortions are performed, i.e. good and easily accessible family planning services.

  6. Induced abortion and contraception in Italy.

    Spinelli, A; Grandolfo, M E

    1991-09-01

    This article discusses the legal and epidemiologic status of abortion in Italy, and its relationship to fertility and contraception. Enacted in May 1978, Italy's abortion law allows the operation to be performed during the 1st 90 days of gestation for a broad range of health, social, and psychological reasons. Women under 18 must receive written permission from a parent, guardian, or judge in order to undergo an abortion. The operation is free of charge. Health workers who object to abortion because of religious or moral reasons are exempt from participating. Regional differences exist concerning the availability of abortion, easy to procure in some places and difficult to obtain in others. After an initial increase following legalization, the abortion rate was 13.5/1000 women aged 15-44 and the abortion ratio was 309/1000 live births -- an intermediate rate and ratio compared to other countries. By the time the Abortion Act of 1978 was adopted, Italy already had one of the lowest fertility levels in Europe. Thus, the legalization of abortion has had no impact on fertility trends. Contrary to initial fears that the legalization of abortion would make abortion a method of family planning, 80% of the women who sought an abortion in 1983-88 were using birth control at the time (withdrawal being the most common method used by this group). In fact, most women who undergo abortions are married, between the ages of 25-34, and with at least one child. Evidence indicates widespread ignorance concerning reproduction. In a 1989 survey, only 65% of women could identify the fertile period of the menstrual cycle. Italy has no sex education in schools or national family planning programs. Compared to most of Europe, Italy still has low levels of reliable contraceptive usage. This points to the need to guarantee the availability of abortion.

  7. 补肾安胎冲剂对复发性流产患者血清血管内皮生长因子及其可溶性受体-1的影响%Effects of Granules for Tonifying Kidney and Preventing Miscarriage on Serum Levels of Vascular Endothelial Growth Factor and Soluble Fms-like Tyrosine Kinase-1 in Patients with Recurrent Spontaneous Abortion

    李伟莉; 胡瑞华

    2013-01-01

    目的 探讨补肾安胎冲剂治疗复发性流产(recurrent spontaneous abortion,RSA)的机制.方法 采用酶联免疫吸附法检测30例RSA患者治疗前后及30例正常早孕妇女血清血管内皮生长因子(vascular endothelial growth factor,VEGF)及其受体--可溶性fms样酪氨酸激酶-1(soluble fms-like tyrosine kinase-1,sFlt-1)的水平.结果 治疗组妊娠成功率为80.0%;与对照组比较,治疗组治疗前血清VEGF显著降低(P<0.01),sFlt-1显著增高(P<0.01);治疗组治疗后与治疗前比较,VEGF显著升高(P<0.01),sFlt-1显著降低(P<0.01);保胎治疗无效者与保胎治疗成功者比较,血清VEGF水平显著降低(P<0.01),血清sFlt-1水平显著增高(P<0.05).结论 补肾安胎冲剂治疗RSA的机制可能与提高血清VEGF水平,降低血清sFlt-1水平,从而促进胎盘绒毛血管的形成有关.%Objective To investigate the mechanism by -which Granules for tonifying the kidney and preventing miscarriage exert therapeutic effect in patients with recurrent spontaneous abortion (RSA). Methods Thirty RSA patients (as treatment group) and 30 women with normal early pregnancy (as control group) were included in this study. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) before and after treatment with the granules for tonifying the kidney and preventing miscarriage. Results The success rate of pregnancy was 80. 00% in the treatment group. Before treatment, the treatment group had significantly lower serum VEGF level and significantly higher serum sFlt-1 level than the control group (P

  8. Immunohistochemical detection of Brucella melitensis antigens in cases of naturally occurring abortions in sheep.

    Ilhan, Fatma; Yener, Zabit

    2008-11-01

    Brucella melitensis, a worldwide zoonotic pathogen, is a significant cause of abortion in sheep and goats in some countries. The present study was carried out to determine, by immunohistochemistry, the presence of B. melitensis antigens in 110 naturally occurring aborted sheep fetuses. Sections of lung, liver, kidney, and spleen of each fetus were stained with immunoperoxidase to detect Brucella antigens. Brucella melitensis antigens were detected in 33 of 110 fetuses (30%). In the 33 positive cases, Brucella antigens were found in lung (25 [22.7%]), liver (21 [19%]), spleen (13 [11.8%]), and kidney (6 [5.4%]). Microscopic studies demonstrated that Brucella antigens were mainly located in the cytoplasm of macrophages and neutrophils of the lung, and in the cytoplasm of macrophages in the portal infiltrates and Kupffer cells of the liver. It was concluded that immunohistochemistry in formalin-fixed, paraffin-embedded tissues is a useful tool for the diagnosis of spontaneous ovine abortion caused by B. melitensis.

  9. 淋巴细胞主动免疫治疗对反复自然流产的疗效分析及其护理策略%Effect of Lymphocytes Active Immunotherapy on Recurrent Spontaneous Abortion and its Nursing Measures

    黄华英; 孙鸿燕; 廖运梅

    2012-01-01

    Objective To investigate the effect of lymphocytes active immunotherapy on recurrent spontaneous abortion (RSA) and its nursing measures . Methods From April 2010 to September 2011, a total of 154 RSA cases who underwent lymphocytes active immunotherapy treatment were included into this study . The procedure of this treatment were the following , peripheral blood lymphocytes of husband (healthy individuals ) were collected . If the spouse should not be used as immunogen , then selected unrelated healthy individuals lymphocytes . The standard of the efficacy was the maintenance of pregnancy to 20 gestation weeks . The nursing measures were: improve the registration and management system , good psychological counseling and strict care practices . All of the 154 patients completed the follow-up. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Affiliated Hospital of Luzhou Medical College . Informed consent was obtained from each participate . Results ①After receiving two courses of immune therapy , positive for anti-phospholipid antibody (APLA) was 146 cases (94.81%), there had significant difference between before and after the treatment (P<0. 01). ② Among 154 patients, 136 cases(88 .31% ) were re-pregnancy ; pregnancy to 20 weeks after the 98 cases , 28 cases in the course of treatment in pregnancy. Conclusions Lymphocytes active immunotherapy is safe and effective. But whether it is worthy of clinical application , further studies are needed to confirm . The improvement of the registration and management system , good psychological counseling , strict care practices and timely guidance of the health care strategy can improve the quality of care to the patients .%目的 探讨采用淋巴细胞主动免疫治疗对反复自然流产(RSA)的疗效及其护理策略.方法 选择2010年4月至2011年9月于本院确诊为RSA后完成淋巴细胞主动免疫治疗,并成功随访的154例患者为研究对象.淋巴

  10. Is Induced Abortion Really Declining in Armenia?

    Jilozian, Ann; Agadjanian, Victor

    2016-06-01

    As in other post-Soviet settings, induced abortion has been widely used in Armenia. However, recent national survey data point to a substantial drop in abortion rates with no commensurate increase in modern contraceptive prevalence and no change in fertility levels. We use data from in-depth interviews with women of reproductive age and health providers in rural Armenia to explore possible underreporting of both contraceptive use and abortion. While we find no evidence that women understate their use of modern contraception, the analysis suggests that induced abortion might indeed be underreported. The potential for underreporting is particularly high for sex-selective abortions, for which there is growing public backlash, and medical abortion, a practice that is typically self-administered outside any professional supervision. Possible underreporting of induced abortion calls for refinement of both abortion registration and relevant survey instruments. Better measurement of abortion dynamics is necessary for successful promotion of effective modern contraceptive methods and reduction of unsafe abortion practices.

  11. Key determinants of induced abortion in women seeking postabortion care in hospital facilities in Ouagadougou, Burkina Faso

    Ilboudo PGC

    2014-05-01

    Full Text Available Patrick GC Ilboudo,1–3 Serge MA Somda,4 Johanne Sundby3 1Département de Santé Publique, Unité de Recherche sur les Politiques et Systèmes de Santé, Centre Muraz, Bobo-Dioulasso, Burkina Faso; 2Agence de Formation, de Recherche et d'Expertise en Santé pour l'Afrique (AFRICSanté, Bobo-Dioulasso, Burkina Faso; 3Department of Community Medicine, University of Oslo, Oslo, Norway; 4Département des Maladies Non Transmissibles, Unité de Formation et d'Appui Méthodologique, Centre Muraz, Bobo-Dioulasso, Burkina Faso Introduction: Despite the universal recognition of unsafe abortion as a major public health problem, very little research has been conducted to document its precipitating factors in Burkina Faso. Our aim was to investigate the key determinants of induced abortion in a sample of women who sought postabortion care. Materials and methods: A cross-sectional household survey was carried out from February to September 2012 in Ouagadougou, Burkina Faso. Data of 37 women who had had an induced abortion and 267 women who had had a spontaneous abortion were prospectively collected on sociodemographic characteristics, pregnancy and birth history, abortion experience, including previous abortion experience, and selected clinical information, including the type of abortion. A two-step regression analysis consisting of a univariate and a multivariate logistic regression was run on Stata version 11.2 in order to identify the key determinants of induced abortion. Results: The findings indicated that 12% of all abortions were certainly induced. Three key factors were significantly and positively associated with the probability of having an induced abortion: whether the woman reported that her pregnancy was unwanted (odds ratio [OR] 10.45, 95% confidence interval [CI] 3.59–30.41; whether the woman reported was living in a household headed by her parents (OR 6.83, 95% CI 2.42–19.24; and if the woman reported was divorced or widowed (OR 3.47, 95

  12. RHIC Abort Kicker Prefire Report

    Tan, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Perlstein, S. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.

    2014-07-07

    In an attempt to discover any pattern to prefire events, abort prefire kicker data from 2007 to the present day have been recorded. With the 2014 operations concluding, this comprises 8 years of prefire data. Any activities that the Pulsed Power Group did to decrease prefire occurrences were recorded as well, but some information may be missing. The following information is a compilation of the research to date.

  13. Differential Impact of Abortion on Adolescents and Adults.

    Franz, Wanda; Reardon, David

    1992-01-01

    Compared adolescent and adult reactions to abortion among 252 women. Compared to adults, adolescents were significantly more likely to be dissatisfied with choice of abortion and with services received, to have abortions later in gestational period, to feel forced by circumstances to have abortion, to report being misinformed at time of abortion,…

  14. From unwanted pregnancy to safe abortion: Sharing information about abortion in Asia through animation.

    Krishnan, Shweta; Dalvie, Suchitra

    2015-05-01

    Although unsafe abortion continues to be a leading cause of maternal mortality in many countries in Asia, the right to safe abortion remains highly stigmatized across the region. The Asia Safe Abortion Partnership, a regional network advocating for safe abortion, produced an animated short film entitled From Unwanted Pregnancy to Safe Abortion to show in conferences, schools and meetings in order to share knowledge about the barriers to safe abortion in Asia and to facilitate conversations on the right to safe abortion. This paper describes the making of this film, its objectives, content, dissemination and how it has been used. Our experience highlights the advantages of using animated films in addressing highly politicized and sensitive issues like abortion. Animation helped to create powerful advocacy material that does not homogenize the experiences of women across a diverse region, and at the same time emphasize the need for joint activities that express solidarity.

  15. An unusual complication of unsafe abortion

    Sunita Gupta

    2011-01-01

    Full Text Available Unsafe abortion is a significant medical and social problem worldwide. In developing countries, most of the unsafe abortions are performed by untrained personnel leading to high mortality and morbidity. Case Report: A 30 year-old female, gravida 7, para 6 underwent uterine evacuation for heavy bleeding per vaginum following intake of abortifacient to abort a 14 weeks gestation. The procedure was performed at a rural setup and her bowel was pulled out of the introitus through the perforated wound, an unusual complication of unsafe abortion. Illiteracy, unawareness about health services, and easy accessibility to untrained abortion providers lead to very high mortality and morbidity in India. There is unmet need to bring awareness among the people about the safe and effective methods of contraception and abortion services to avoid such complications.

  16. Health benefits of legal abortion: an analysis.

    Tyrer, L B

    1985-01-01

    The abolition of legal abortion in the US would seriously threaten the health, and even the lives, of women and children. Statistics on the relationship between abortion and health attained before and after abortion was legalized were used to project some of the probable consequences of reversing the US Supreme Court's 1973 Roe v. Wade decision. Abortion has been widely practiced throughout US history, but the actual number of procedures performed before some states legalized abortion is unknown. Few legal procedures were performed for medical reasons, yet many illegal abortions took place. In 1955, a panel of experts could only provide a "best estimate" of between 200,000 and 1,200,000 illegally induced abortions occurring annually in the US. The actual number was most likely closer to the higher figure. The complication rates for illegal abortions, most of which were performed by unskilled practitioners in unsafe settings, were much higher than the rates for legal abortion now. Complications were related to ineffective or unsafe methods, Sepsis, particularly with the bacterium "Clostridium prefringens," which causes gas gangrene, was a major problem that has virtually disappeared. Each year prior to the 1970s, more than 100 women in the US died of abortion complications. Due to the fact that vital statistics reflect an incomplete ascertainment of deaths, the actual number of deaths is probably larger, possibly by as much as 50%. In 1983 more than 1.3 million procedures were performed -- a figure close to the estimated number of illegal abortions performed before 1970. In comparison, 672,000 hysterectomies and 424,000 tonsillectomy operations were performed the same year. The number of abortion-related deaths in the US decreased between 1972 and 1980, from 90 to 16. Most of this decrease resulted from the availability and safety of legal abortion. Legal abortion carries an especially low risk of death, particularly when performed in the 1st trimester. For the 1972

  17. Further Tests of Abortion and Crime

    2004-01-01

    The inverse relationship between abortion and crime has spurred new research and much controversy. If the relationship is causal, then polices that increased abortion have generated enormous external benefits from reduced crime. In previous papers, I argued that evidence for a casual relationship is weak and incomplete. In this paper, I conduct a number of new analyses intended to address criticisms of my earlier work. First, I examine closely the effects of changes in abortion rates between ...

  18. Conscientious refusal to assist with abortion.

    Dooley, D

    1994-09-10

    Abortion is a moral issue affecting the identity and integrity of physicians and nurses. Ethical reasoning helps reasonable and sincere people who do not agree on abortion to understand the sources of disagreement and to explore shared principles in the differences. Discussions of abortion cannot be limited to the conflict between the rights of a woman to control her reproduction and the rights of a fetus to live. Religious, cultural, feminist, and political beliefs must also be considered. This complexity must be considered when examining whether physicians and nurses have rights to refuse to assist in abortion on conscientious grounds. People with fundamentally different moral outlooks already determine what is morally right or wrong, good or evil. Health professionals who refuse to assist in abortion base their decision on beliefs about moral duties, injunctions of natural law, and the essentially nonnegotiable rights of people to be protected from intentional harm. They know and regret the adverse effects for pregnant women but there is no compelling motivation to change their opposition to abortion. There is no morally neutral position from which to judge conscientious refusals in abortion. Society should develop a position that respects autonomy of belief and grants the right to physicians and nurses to conscientiously refuse to assist in abortions. In those countries where the abortion law grants physicians the right to refuse but not nurses, society needs to reflect on why nurses have been accorded second class professional and moral status. In those countries which have not yet formulated an abortion law, the government should consider how it can find enough health workers who will in good conscience assist in abortions. Governments must first seriously consider a presumptive right to conscientious refusal in abortion before health systems can redistribute sectors of responsibility among health workers and implement changes in recruitment policies for

  19. Hemolysis, hemorrhage, headache, and hidden abortion: imaging findings in antiphospholipid syndrome

    Mahnken, A.H.; Brandenburg, V.M.; Haage, P.; Guenther, R.W. [Dept. of Diagnostic Radiology, Univ. Hospital, Univ. of Technology, Aachen (Germany); Frank, R.D. [Dept. of Nephrology and Immunology, Univ. of Technology, Aachen (Germany)

    2003-12-01

    Antiphospholipid antibodies are associated with arterial and venous thromboses, recurrent pregnancy loss, and organ infarction. Any vascular region can be affected. We present a 20-year-old woman suffering from secondary antiphospholipid syndrome with a unique combination of multifocal venous thromboses, pulmonary embolism, spontaneous abortion, and splenic infarction. Diversity of clinical symptoms and diagnostic imaging modalities are discussed with emphasis on cross-sectional imaging. The syndrome should be suspected in patients with thromboses and organ infarctions of otherwise undetermined etiology. (orig.)

  20. Secondary infertility caused by the retention of fetal bones after an abortion: a case report

    Kramer Hannah MC; Rhemrev Johann PT

    2008-01-01

    Abstract Introduction Unwanted contraception through prolonged retention of fetal bone is a rare cause of secondary infertility. It is usually associated with a history of abortion, either spontaneous or induced. Case presentation We describe a case of intrauterine retention of fetal bone diagnosed 8 years after the termination of a pregnancy. The patient had no complaints of pain, irregular vaginal bleeding or discharge. A hysteroscopy was performed and irregular structures were removed. The...

  1. Plasma β-Endorphin Levels in Women with Early Threatened Abortion before and after the Treatment of Integrated Chinese and Western Medicine

    孙斐; 俞瑾

    1999-01-01

    To observe plasma β-endorphin(β-EP)and gonadotrophin releasing hormone(GnRM),human chorionic gonadotrophin(hCG),progesterone (P4) levels in women with early threatened abortion and with a history of recurrent spontaneous abortions(RSA).Twenty patients with threatened abortion at 7-8 weeks of gestation were re-cruited,all of them had a history of 3 or more recurrent unexplained abortions.They were treated with psychological consultation accompanied by traditional Chinese herbs.Blood samples were taken to measure β-EP,GnRM,hCG and P4 levels by radioim-munoassay(RIA).The treatments were continued till 10-12 weeks,blood was taken during this period to compare changes in these peptides/hormones.Twenty normal pregnant women at 7-8 and 10-12weeks and 20patients with incomplete abortion at 10- 12weeks were recruited for comparative studies.Results:(1)In normal pregnant women,plasma β-EP,GnRH,hCG and P4 levels at 10-12 weeks were significantly higher than that at 7-8 weeks(P0.05).(3)Plasma β-EP levels in patients with incomplete abortions at 10-12 weeks were dramatically higher and GnRH,hCG and P4levels were lower than in normal pregnant women(P<0.01).β-EP might play a role in the pathophysiology of spontaneous abortion.

  2. Therapeutic abortion follow-up study.

    Margolis, A J; Davison, L A; Hanson, K H; Loos, S A; Mikkelsen, C M

    1971-05-15

    To determine the long-range psychological effects of therapeutic abortion, 50 women (aged from 13-44 years), who were granted abortions between 1967 and 1968 Because of possible impairment of mental and/or physical health, were analyzed by use of demographic questionnaires, psychological tests, and interviews. Testing revealed that 44 women had psychiatric problems at time of abortion. 43 patients were followed for 3-6 months. The follow-up interviews revealed that 29 patients reacted positively after abortion, 10 reported no significant change and 4 reacted negatively. 37 would definitely repeat the abortion. Women under 21 years of age felt substantially more ambivalent and guilty than older patients. A study of 36 paired pre- and post-abortion profiles showed that 15 initially abnormal tests had become normal. There was a significant increase in contraceptive use among the patients after the abortion, but 4 again became pregnant and 8 were apparently without consistent contraception. It is concluded that the abortions were therapeutic, but physicians are encouraged to be aware of psychological problems in abortion cases. Strong psychological and contraceptive counselling should be exercised.

  3. Abortion in Iranian legal system: a review.

    Mahmoud Abbasi

    2014-02-01

    Full Text Available Abortion traditionally means, "to miscarry" and is still known as a problem which societies has been trying to reduce its rate by using legal means. Despite the pregnant women and fetuses have being historically supported; abortion was firstly criminalized in 1926 in Iran, 20 years after establishment of modern legal system. During next 53 years this situation changed dramatically, so in 1979, the time of Islamic Revolution, aborting fetuses before 12 weeks and therapeutic abortion (TA during all the pregnancy length was legitimate, based on regulations that used medical justification. After 1979 the situation changed into a totally conservative and restrictive approach and new Islamic concepts as "Blood Money" and "Ensoulment" entered the legal debates around abortion. During the next 33 years, again a trend of decriminalization for the act of abortion has been continuing. Reduction of punishments and omitting retaliation for criminal abortions, recognizing fetal and maternal medical indications including some immunologic problems as legitimate reasons for aborting fetuses before 4 months and omitting the fathers' consent as a necessary condition for TA are among these changes. The start point for this decriminalization process was public and professional need, which was responded by religious government, firstly by issuing juristic rulings (Fatwas as a non-official way, followed by ratification of "Therapeutic Abortion Act" (TAA and other regulations as an official pathway. Here, we have reviewed this trend of decriminalization, the role of public and professional request in initiating such process and the rule-based language of TAA.

  4. STUDY OF THYROID PROILE IN PATIENTS OF RECURRENT ABORTIONS

    Amit R.

    2013-12-01

    Full Text Available ABSTRACT: INTRODUCTION: Recurrent spontaneous abort ion of unknown etiology provided fundamental insight into process of embryogenesis, and implantation. It is also a frustrating and emotionall y charged clinical problem . Hormonal imbalances are important cause of recurrent pregnancy loss, in the 1 st trimester as well as in 2 nd trimester. Thyroid diseases are the commonest disorders affecting women of reproductive age group . They constitute the com monest endocrine disorder complicating pregnancy. In women incidence of hypothyroidism diagnosed before pregnancy is 1%. Maternal and fetal complications have been found to be higher in this population. In women incidence of hypothyroidism diagnosed before pregnancy is 1%. Maternal and fetal complications have been found to be higher in this popu lation. OBJECTIVE : We studied the Thyroid profile in patients of recurrent abortion. MATERIALS AND METHODS : 60 non pregnant healthy women with complaints of vaginal bleeding, pelvic pain, tissue discharge up to 8, 16, and 22 weeks with 20 subjects in each group. Details of history, physical findings, laboratory evaluation and medication were noted from their case records and verified. 60 healthy, pregnant women who w ere at same gestational age and then reached the term and had successful pregnancy outcome, were selected as controls. The controls were not under any regimen and were free from any chronic illness. Elisa method was used for estimation of thyroid hormones. RESULTS: We studied 60 non pregnant healthy women (27±2.6 years with established diagnosis of recurrent spontaneous abortion. Serum TT3, fT3, TT4, fT4 was found to be significantly low in cases as compared to controls. 21 women out of 60 i.e. 35 % showed overt hypothyroidism. Majority of these cases were showing recurrent pregnancy lost in between 8 - 16 weeks of gestation when their history was traced. CONCLUSION : Hypothyroidism is frequent cause in recurrent pregnancy loss. Severe

  5. Rates of induced abortion in Denmark according to age, previous births and previous abortions

    Marie-Louise H. Hansen

    2009-11-01

    Full Text Available Background: Whereas the effects of various socio-demographic determinants on a woman's risk of having an abortion are relatively well-documented, less attention has been given to the effect of previous abortions and births. Objective: To study the effect of previous abortions and births on Danish women's risk of an abortion, in addition to a number of demographic and personal characteristics. Data and methods: From the Fertility of Women and Couples Dataset we obtained data on the number of live births and induced abortions by year (1981-2001, age (16-39, county of residence and marital status. Logistic regression analysis was used to estimate the influence of the explanatory variables on the probability of having an abortion in a relevant year. Main findings and conclusion: A woman's risk of having an abortion increases with the number of previous births and previous abortions. Some interactions were was found in the way a woman's risk of abortion varies with calendar year, age and parity. The risk of an abortion for women with no children decreases while the risk of an abortion for women with children increases over time. Furthermore, the risk of an abortion decreases with age, but relatively more so for women with children compared to childless women. Trends for teenagers are discussed in a separate section.

  6. STUDY OF WHO SAFE ABORTION REGIMEN IN MEDICAL ABORTIONS IN A TERTIARY CENTRE

    Joylene Diana; Sujaya V.

    2015-01-01

    Medical abortion is the use of drugs to induce abortion of a fetus. Due to the advances in the field of research , numerous regimens have been formulated to ensure a fast and complete expulsion of the fetus. These regimens also aim to towards reduced post abortal side effects and to decrease the need for surgical evacuation ...

  7. Why women are dying from unsafe abortion: narratives of Ghanaian abortion providers.

    Payne, Carolyn M; Debbink, Michelle Precourt; Steele, Ellen A; Buck, Caroline T; Martin, Lisa A; Hassinger, Jane A; Harris, Lisa H

    2013-06-01

    In Ghana, despite the availability of safe, legally permissible abortion services, high rates of morbidity and mortality from unsafe abortion persist. Through interviews with Ghanaian physicians on the front lines of abortion provision, we begin to describe major barriers to widespread safe abortion. Their stories illustrate the life-threatening impact that stigma, financial restraints, and confusion regarding abortion law have on the women of Ghana who seek abortion. They posit that the vast majority of serious abortion complications arise in the setting of clandestine or self-induced second trimester attempts, suggesting that training greater numbers of physicians to perform second trimester abortion is prerequisite to reducing maternal mortality. They also recognized that an adequate supply of abortion providers alone is a necessary but insufficient step toward reducing death from unsafe abortion. Rather, improved accessibility and cultural acceptability of abortion are integral to the actual utilization of safe services. Their insights suggest that any comprehensive plan aimed at reducing maternal mortality must consider avenues that address the multiple dimensions which influence the practice and utilization of safe abortion, especially in the second trimester.

  8. Abortion Decision and Ambivalence: Insights via an Abortion Decision Balance Sheet

    Allanson, Susie

    2007-01-01

    Decision ambivalence is a key concept in abortion literature, but has been poorly operationalised. This study explored the concept of decision ambivalence via an Abortion Decision Balance Sheet (ADBS) articulating reasons both for and against terminating an unintended pregnancy. Ninety-six women undergoing an early abortion for psychosocial…

  9. Medical abortion practices : a survey of National Abortion Federation members in the United States

    Wiegerinck, Melanie M. J.; Jones, Heidi E.; O'Connell, Katharine; Lichtenberg, E. Steve; Paul, Maureen; Westhoff, Carolyn L.

    2008-01-01

    Background: Little is known about clinical implementation of medical abortion in the United States following approval of mifepristone as an abortifacient by the Food and Drug Administration (FDA) in 2000. We collected information regarding medical abortion practices of National Abortion Federation (

  10. ACOG Committee opinion no. 612: Abortion training and education.

    2014-11-01

    Access to safe abortion hinges upon the availability of trained abortion providers. The American College of Obstetricians and Gynecologists supports education for students in health care fields as well as clinical training for residents and advanced practice clinicians in abortion care in order to increase the availability of trained abortion providers. The American College of Obstetricians and Gynecologists supports the expansion of abortion education and an increase in the number and types of trained abortion providers in order to ensure women's access to safe abortions. Integrated medical education and universal opt-out training policies help to lessen the stigma of abortion provision and improve access by increasing the number of abortion providers. This Committee Opinion reviews the current status of abortion education, describes initiatives to ensure the availability of appropriate and up-to-date abortion training, and recommends efforts for integrating and improving abortion education in medical schools, residency programs, and advanced practice clinician training programs.

  11. Spontaneous obliteration highlights the dynamic nature of cerebral arteriovenous malformations: A case report and review of the literature

    Su Lone Lim

    2016-01-01

    Conclusion: In our center′s 20-year experience of treatment of cerebral AVMs (approximately 600 cases, this is the only case that has been aborted due to spontaneous obliteration leading us to infer that the incidence of spontaneous AVM obliteration is <1%. Spontaneous obliteration of AVM is a rare but well-established phenomenon that bears testimony to the dynamics of this vascular disorder.

  12. Aftershocks: The Impact of Clinic Violence on Abortion Services

    2010-01-01

    Between 1973 and 2003, abortion providers in the United States were the targets of over 300 acts of extreme violence. Using unique data on attacks and on abortions, abortion providers, and births, we examine how anti-abortion violence has affected providers' decisions to perform abortions and women's decisions about whether and where to terminate a pregnancy. We find that clinic violence reduces abortion services in targeted areas. Once travel is taken into account, however, the overall effec...

  13. Shuttle Abort Flight Management (SAFM) - Application Overview

    Hu, Howard; Straube, Tim; Madsen, Jennifer; Ricard, Mike

    2002-01-01

    One of the most demanding tasks that must be performed by the Space Shuttle flight crew is the process of determining whether, when and where to abort the vehicle should engine or system failures occur during ascent or entry. Current Shuttle abort procedures involve paging through complicated paper checklists to decide on the type of abort and where to abort. Additional checklists then lead the crew through a series of actions to execute the desired abort. This process is even more difficult and time consuming in the absence of ground communications since the ground flight controllers have the analysis tools and information that is currently not available in the Shuttle cockpit. Crew workload specifically abort procedures will be greatly simplified with the implementation of the Space Shuttle Cockpit Avionics Upgrade (CAU) project. The intent of CAU is to maximize crew situational awareness and reduce flight workload thru enhanced controls and displays, and onboard abort assessment and determination capability. SAFM was developed to help satisfy the CAU objectives by providing the crew with dynamic information about the capability of the vehicle to perform a variety of abort options during ascent and entry. This paper- presents an overview of the SAFM application. As shown in Figure 1, SAFM processes the vehicle navigation state and other guidance information to provide the CAU displays with evaluations of abort options, as well as landing site recommendations. This is accomplished by three main SAFM components: the Sequencer Executive, the Powered Flight Function, and the Glided Flight Function, The Sequencer Executive dispatches the Powered and Glided Flight Functions to evaluate the vehicle's capability to execute the current mission (or current abort), as well as more than IS hypothetical abort options or scenarios. Scenarios are sequenced and evaluated throughout powered and glided flight. Abort scenarios evaluated include Abort to Orbit (ATO), Transatlantic

  14. Induced abortion in China and the advances of post abortion family planning service

    Li Ying; Cheng Yi-ming; Huang Na; Guo Xin; Wang Xian-mi

    2004-01-01

    This is a review of current situation of induced abortion and post abortion family planning service in China. Induced abortion is an important issue in reproductive health. This article reviewed the distribution of induced abortion in various time, areas, and population in China, and explored the character, reason, and harm to reproductive health of induced abortion.Furthermore, this article introduces the concept of Quality of Care Program in Family Planning,and discusses how important and necessary it is to introduce Quality of Care Program in Family Planning to China.

  15. Abortion and infant mortality before and after the 1973 US Supreme Court decision on abortion.

    Robertson, L S

    1981-07-01

    The 50 states of the US were compared in 1971-72 and 1974-75 with respect to percentage apparent conceptions aborted and infant mortality rates attributed to various causes. Only nonvehicle accidental deaths were consistently related to abortion. The correlation is nonlinear; nonvehicle accidental deaths were especially high in states with little or no abortion. A decline in nonvehicle accidental deaths from before to after the Supreme Court decision was most pronounced in states where there were fewest abortions before the decision and where increases in abortion followed the decision.

  16. Adolescents and Abortion: Choice in Crisis.

    Stone, Rebecca

    This publication seeks to explain the many facets of adolescent abortion: teenagers' need for access to safe abortion; the need for confidentiality in order to ensure safety; the real intent and effect of parental involvement laws; and the roles of parents and the state in safeguarding the health of pregnant teenagers. The first section looks at…

  17. Strategies for the prevention of unsafe abortion.

    Faúndes, Anibal

    2012-10-01

    Unsafe abortion is one of the main causes of maternal mortality and severe morbidity in countries with restrictive abortion laws. In 2007, the International Federation of Gynecology and Obstetrics (FIGO) created a Working Group on the Prevention of Unsafe Abortion and its Consequences (WGPUA). This led to a FIGO initiative with that aim which has the active participation of 43 FIGO member societies. The WGPUA has recommended that the plans of action of the countries participating in the initiative consider several levels of prevention shown to have the potential to successfully reduce unsafe abortions: (1) primary prevention of unintended pregnancy and induced abortion; (2) secondary prevention to ensure the safety of an abortion procedure that could not be avoided; (3) tertiary prevention of further complications of an unsafe abortion procedure that has taken place already, through high-quality postabortion care; and (4) quaternary prevention of repeated abortion procedures through postabortion family planning counseling and contraceptive services. This paper reviews these levels of prevention and the evidence that they can be effective.

  18. Abortion: The Viewpoint of Potential Consumers

    Hamrick, Michael H.; And Others

    1977-01-01

    A college survey showed strong support by a majority for legalized abortion, governmental support of abortion and family planning services, voluntary sterilization, and sex education and birth control information and/or services in the schools. Important differences of opinion among subgroups were, however, indicated. (Author/MJB)

  19. Provokeret abort og stratificeret reproduktion i Danmark

    Gammeltoft, Tine; Rasch, Vibeke; Knudsen, Lisbeth B.

    2007-01-01

    Hvorfor får kvinder med indvandrerbaggrund dobbelt så mange provokerede aborter som andre kvinder i Danmark? Det var udgangsspørgsmålet for det forskningsprojekt, denne artikel er baseret på. Artiklens argument er, at når nogle grupper af minoritetskvinder får flere aborter end andre kvinder i...

  20. Violence against abortion increases in US clinics.

    Roberts, J

    1994-08-13

    In the US, violence against abortion clinics is escalating. In July 1994, a doctor who performed abortions and one of his escorts was gunned down outside of an abortion clinic. In March of 1993, another doctor was killed outside of a clinic. That killing prompted passage of a federal law designed to protect abortion providers and clinics from violence. In addition to the individuals murdered, the number of violent incidents against abortion clinics increased four-fold to 250 in 1993. Some elderly physicians feel compelled to continue to perform the procedure instead of retiring because there are no young practitioners to replace them. These physicians note that the young practitioners have no experience with the deaths and illness which resulted from illegal abortions and have not been properly trained by their medical schools. The US Attorney General has dispatched federal marshalls to guard abortion clinics, and local police are increasing their protection of clinics. Abortion protestors say that the new federal law will cause some formerly peaceful protestors to resort to violence.

  1. Fetal Pain, Abortion, Viability and the Constitution

    Cohen, I. Glenn; Sayeed, Sadath Ali

    2011-01-01

    In early 2010, the Nebraska state legislature passed a new abortion restricting law asserting a new, compelling state interest in preventing fetal pain. In this article, we review existing constitutional abortion doctrine and note difficulties presented by persistent legal attention to a socially derived viability construct. We then offer a substantive biological, ethical, and legal critique of the new fetal pain rationale.

  2. Fetal pain, abortion, viability, and the Constitution.

    Cohen, I Glenn; Sayeed, Sadath

    2011-01-01

    In early 2010, the Nebraska state legislature passed a new abortion restricting law asserting a new, compelling state interest in preventing fetal pain. In this article, we review existing constitutional abortion doctrine and note difficulties presented by persistent legal attention to a socially derived viability construct. We then offer a substantive biological, ethical, and legal critique of the new fetal pain rationale.

  3. Induced Abortion: An Ethical Conundrum for Counselors.

    Millner, Vaughn S.; Hanks, Robert B.

    2002-01-01

    Induced abortion is one of the most controversial moral issues in American culture, but counselor value struggles regarding abortion are seldom addressed in counseling literature. This article considers the conflictual nature of the ethical principles of autonomy, fidelity, justice, beneficence, and nonmaleficence as they can occur within the…

  4. The abortion culture issue in Serbia

    Rašević Mirjana

    2011-01-01

    Full Text Available The problem of a large number of abortions in our country was first pointed out as far back as 1935 at the 17th Congress of Yugoslav Physicians. The abortion problem in Serbia is still present today, even though modern science has provided new methods and means which are a logical solution to the dilemma on birth control methods from the health and social aspect. Namely, total abortion rate in Serbia was estimated at 2.76 in the year 2007. It is very high; double the number of the total fertility rate and among the highest in Europe and the world. The term abortion culture was first used, as far as we know, by Henry David in the introduction of the book From Abortion to Contraception - A Resource to Public Policies and Reproductive Behavior in Central and Eastern Europe from 1917 to the Present in 1999, without specifically determining it. The aim of this paper is to identify the most important factors of the deterministic basis of endemic induced abortions in Serbia together with indirectly estimating their connection with the existence, namely nonexistence, of the abortion culture in our country. In that sense, potential factors of abortion incidence in Serbia which emerge from the social system and those connected to the individual level have been considered. In other words, a series of laws and other legal and political documents have been analyzed which are significant for perceiving the abortion matter, as well as institutional frameworks for family planning, health services, educating the youth regarding reproductive health, including findings of numerous researches carried out among women of various age and doctors from 1990 till present day in Serbia. The following most significant factors for the long duration of the abortion problem have been singled out: insufficient knowledge of modern contraception, a belief that modern contraceptive methods are harmful to health and a number of psychological barriers as well as those arising from

  5. Abortion 1982: the Supreme Court once again.

    Healey, J M

    1982-11-01

    Clearly, abortion in the US continues to be a major medico-legal issue which will not go away. 5 major abortion cases are scheduled for review by the US Supreme Court during its 1982-83 term. Taken together, these 5 cases challenge several of the key conclusions of the Court's review of the abortion question. The primary focus of the cases is the state's power to regulate the abortion decision during the 1st and 2nd trimester of the pregnancy. 2 cases involve ordinances passed by the City of Akron regulating access to abortion in areas such as consent and notification requirements and the location of abortions after the 1st trimester. 2 of the cases involve a Missouri statute also dealing with the requirement that abortions after the 1st trimester be performed in a hospital. The final case involves a Virginia criminal prosecution of a physician accused of violating the state's requirement of in-hospital performance of a 2nd trimester abortion. In the case of Roe v. Wade, the Court had established the "trimester trilogy" governing state regulation of the abortion procedure. For the stage of the pregnancy prior to the end of the 1st trimester, the Court held that the abortion decision and its effectuation must be left to the medical judgment of the pregnant women's attending physician. For the stage of the pregnancy subsequent to the end of the 1st trimester, the Court ruled that the state may promote its interest in the health of the mother by regulating the abortion procedure in ways reasonably related to maternal health. For the stage of pregnancy subsequent to viability, the state may promote its interest in the potentiality of human life by regulation, even prohibiting abortion, except where it is necessary to preserve the mother's life or health. These 5 cases challenge the role of the Court in determining the scope of appropriate state regulation at various stages of the pregnancy. Suffering a loss of prestige in the 10 years since the Roe v. Wade and Doe v

  6. [Counter-acception or abort and lie].

    Maruani, G

    1979-09-01

    In this very short but fiery and violent paper against abortion the author states that most women seeking abortion are actually lying to themselves, pretending they want something which, in reality, they do not want, i.e. an abortion. The laws regulating abortion in most countries are such that a woman is practically forbidden to make an independent decision, despite, or because of the number of counseling sessions and of meetings with doctors that she must go through. Radio, television, newspapers and magazines, friends and relatives, all contribute to make of abortion a run-of-the-mill operation, while it should be seen as scandal, and as the total negation of any maternal instinct.

  7. [Therapeutic abortion, unjustified absence in health policy].

    Chávez-Alvarado, Susana

    2013-07-01

    Although abortion for health reasons is not considered a crime in Peru, the State does not allow its inclusion in public policy, thus violating women's right to terminate a pregnancy when it affects their health. When examining the article in the Criminal Code which decriminalizes this type of abortion, provisions are identified which protect women and set the conditions to offer this type of service. This document sets the debate about the arguments used by the Peruvian State for not approving a therapeutic abortion protocol which would regulate the provision and financing of therapeutic abortion in public services, and explains why this obligation should be complied with, based on the conceptual framework of "health exception" In addition, it presents two cases brought before the judicial court in which the Peruvian State was found guilty of violating the human rights of two adolescents to whom a therapeutic abortion was denied.

  8. Major trends in recent abortion research.

    Van Der Tak, J

    1975-05-01

    Abortion research continues actively. 1 finding has been that abortion has distinct regional features. In Western Europe the rights of the woman in relation to the rights of the fetus are under study while Eastern European researchers examine the effect of long standing available abortion on birthrates, women's health, subsequent pregnancies, and contraceptive use. The increase in illegal abortion shows that improved health and contraceptive services, better data, and changes in restrictive laws are necessary. Changes in the laws, either from less to more liberal or the opposite, have brought about national studies of subsequent trends in abortion, maternal and infant mortality, service facilities, contraceptive practice and fertility. The technique of menstrual regulation, performed within 14 days of a missed menstrual period and before pregnancy can be determined, has created new research problems. It raises the questions of whether menstrual regulation can legally be considered an abortion and whether effectiveness rates can be reliably determined if a large proportion of the women are not even pregnant. The relative risks of menstrual regulation in very early pregnancy and vacuum aspiration and dilation and curretage at a later stage are now being researched. The World Health Organization is planning research of the psychosocial aspects of the relationship between the users and providers of abortion services. Also receiving research attention is the incidence of repeat abortions and the effects of an abortion refused. The fact that overall birthrates have not been substantially changed by the liberalization of abortion laws in the last 20 years appears to be associated with the improvement of contraceptive methods.

  9. Aborter

    Schütze, Laura Maria; Warburg, Margit

    2008-01-01

    Mens nogle hospitaler nedgraver aborterede fostre på kirkegården, bortskaffer andre dem som vævsaffald. Tvetydig lovgivning er årsagen. Udgivelsesdato: 15. oktober......Mens nogle hospitaler nedgraver aborterede fostre på kirkegården, bortskaffer andre dem som vævsaffald. Tvetydig lovgivning er årsagen. Udgivelsesdato: 15. oktober...

  10. 稽留流产128例临床分析%Clinical analysis of 128 cases of missed abortion

    孙金凤

    2012-01-01

      Objective: To investigate the incidence of missed abortion factors, diagnosis and method of treatment, prevention of the occurrence of missed abortion. Missed abortion (missed abortion) refers to the embryo or fetus has retained intrauterine death not naturaly discharged ( 1 ), is a special type of spontaneous abortion. Causes of missed abortion for many reasons, but the mechanism is not clear. Methods: the retrospective approach on clinical data analysis of missed abortion. Results: the missed abortion and fetal genetic defects, adverse external factors and the effect of maternal disease of. Conclusion: the incidence of missed abortion factors, diagnosis and method of treatment, prevention of the occurrence of missed abortion, on the health of women of childbearing age has important significance. Fetal genetic defects, chromosome abnormality is the main reason of occurrence of missed abortion. B ultrasound is the main diagnostic methods. The diagnosis should be promptly after the evacuation of uterus.%  目的探讨稽留流产的发病因素,诊断及治疗方法,预防稽留流产的发生.稽留流产(missed abortion)是指胚胎或胎儿已死亡滞留宫腔内未能及时自然排出者[1],是自然流产的一种特殊类型.造成稽留流产的原因很多,但机制尚不明确.方法采用回顾性方法对稽留流产的临床资料进行分析.结果稽留流产与胎儿遗传基因的缺陷、外界不良因素的影响及母体疾患有关.结论探讨稽留流产的发病因素,诊断及治疗方法,预防稽留流产的发生,对育龄妇女的身心健康有着重要的意义.胎儿遗传基因的缺陷,染色体异常是发生稽留流产的主要原因.B超是主要的诊断方式.诊断明确后应及时排空子宫.

  11. STUDY OF WHO SAFE ABORTION REGIMEN IN MEDICAL ABORTIONS IN A TERTIARY CENTRE

    Joylene Diana

    2015-07-01

    Full Text Available Medical abortion is the use of drugs to induce abortion of a fetus. Due to the advances in the field of research , numerous regimens have been formulated to ensure a fast and complete expulsion of the fetus. These regimens also aim to towards reduced post abortal side effects and to decrease the need for surgical evacuation post medical abortion. The objective of this cros s sectional analysis was to study the effectiveness of the WHO safe abortion regimen in a tertiary care hospital . METHODS: A total of 60 patients with pregnancies of 12 to 30 weeks of gestation and in whom a medical abortion was deemed necessary were chosen . After instituting the WHO SAFE ABORTION regimen they were analysed based on indication for pregnancy termination , onset of pain with WHO regimen and time of expulsion as well as post abortal side effects and the need for surgical evacuation due to failure of the WHO safe abortion regimen. Post abortion an ultrasound was done to confirm the success of the regimen . RESULTS: Majority of patients in our study was multiparous and Mean gestational age for pregnancy termination was 20.6 weeks . The most common indication for medical abortion was incidental diagnosis of fetal demise or fetal anomaly on ultrasonography ( 43.6% . The average duration for onset of pain was 3 hours and the average time needed for expulsion was 6 hours from the start of the Abortion regimen . The most common post abortal side effect was excessive bleeding . Only about 13.3 percent patients needed a surgical evacuation due to failure of the regimen. CONCLUSION: This study showed that the WHO safe abortion regimen is highly effective and a desirable method for medical termination of pregnancy , especially in early pregnancy and in patients in whom a surgical method of abortion could pose as a risk . The WHO SAFE ABORTION regimen has minimal post abortal side effects , need for surgical intervention and the time needed for expulsion is less. Hence it

  12. Humoral immune response to an allogenic foetus in normal fertile women and recurrent aborters

    Mishra LC

    2002-08-01

    Full Text Available Abstract Background Several humoral immune factors are responsible for a successful pregnancy. There are a few studies, which demonstrate the role of antipaternal cytotoxic antibodies (APCA and mixed lymphocyte reaction blocking factor (MLR-Bf in the maintenance of pregnancy. However, these factors have not been studied in women with history of recurrent spontaneous abortion (RSA. We designed this study to review the role of APCA and MLR-Bf in normal pregnancy as well as in women with a history of RSA. Methods One hundred and five women with unexplained recurrent spontaneous abortion were included in the present study. These women were screened for all other known causes of recurrent abortion. We also included 60 normal fertile women, fifteen from each trimester and fifteen women during the post partum period (up to six months. RSA and controls (normal pregnancy were matched for age, caste, and socio economic background and also for parity. APCA and MLR-Bf were evaluated in all the groups. All women with RSA who conceived during the study period were on follow up. Results We have analyzed the status of APCA and MLR-Bf in normal pregnancy (different gestational periods and during post partum, and in women with history of RSA. Our results show that APCA was significantly higher in controls as compared to RSA women. MLR-Bf was directed against the husbands' cells in normal pregnancy and was virtually absent in RSA women. Conclusion Our results indicate that there is a significantly low titer of APCA and MLR-Bf in women with recurrent spontaneous abortion. This highlights the role of these factors in the maintenance of successful pregnancy.

  13. Prevalence of Abortion and Contraceptive Practice among Women Seeking Repeat Induced Abortion in Western Nigeria

    Mustafa Adelaja Lamina

    2015-01-01

    Full Text Available Background. Induced abortion contributes significantly to maternal mortality in developing countries yet women still seek repeat induced abortion in spite of availability of contraceptive services. The aim of this study is to determine the rate of abortion and contraceptive use among women seeking repeat induced abortion in Western Nigeria. Method. A prospective cross-sectional study utilizing self-administered questionnaires was administered to women seeking abortion in private hospitals/clinics in four geopolitical areas of Ogun State, Western Nigeria, from January 1 to December 31 2012. Data were analyzed using SPSS 17.0. Results. The age range for those seeking repeat induced abortion was 15 to 51 years while the median age was 25 years. Of 2934 women seeking an abortion, 23% reported having had one or more previous abortions. Of those who had had more than one abortion, the level of awareness of contraceptives was 91.7% while only 21.5% used a contraceptive at their first intercourse after the procedure; 78.5% of the pregnancies were associated with non-contraceptive use while 17.5% were associated with contraceptive failure. The major reason for non-contraceptive use was fear of side effects. Conclusion. The rate of women seeking repeat abortions is high in Nigeria. The rate of contraceptive use is low while contraceptive failure rate is high.

  14. [Medical and social implications of abortion].

    Radu, A; Capra, G

    1988-01-01

    In the course of the evolution of human society the problem or idea of interrupting a pregnancy has been faced many times. Romania has adopted a mixed solution to the termination of pregnancy allowing abortions for medical, eugenic, and social reasons. The 1936 penal code allowed only medical abortion, but recent regulations have offered differing solutions. The old regulation not allowing termination of pregnancy or restricting it was in force with minor modifications until 1957. In 1966 a decree was issued that allowed women with 4 children an abortion for special reasons as determined by an abortion committee, but still therapeutic and strictly medical causes predominated. In 1985 a new regulation of medical law prohibited termination of normal pregnancy up to 28 weeks of gestation and infractions were punishable by law. Illegal induced abortion represents an antisocial manifestation that jeopardizes human relationships in society. Induced abortion occurs often in disintegrated family situations. The social implications of the phenomenon of birth are manyfold. Medical intervention is difficult because of the mutilating effect of abortion. The motives are a matter of reflection for physicians and jurists alike.

  15. A measured response: Koop on abortion.

    Koop, C E

    1989-01-01

    The available scientific literature on the health effects of abortion on women in the US neither supports nor refutes the premise that abortion contributes to psychological problems. The 250 studies that have considered the psychological aspects of abortion are all flawed methodologically. Needed to resolve this issue is a prospective study of a cohort of US women of childbearing age focused on the psychological effects of failure to conceive, as well as the physical and mental sequelae of pregnancy whether carried to delivery, miscarried, or terminated by abortion. The most desirable such study could be conducted for about US$100 million over a 5-year period; a less expensive yet satisfactory study could be conducted for $10 million over the same time frame. Before such a study can be undertaken, a survey instrument must be designed to eliminate the discrepancy between the number of abortions on record and the number of women who admit to having an abortion on survey. Another issue is that the health effects of abortion cannot easily be separated from the controversial social issues surrounding pregnancy termination.

  16. Ireland: child rape case undermines abortion ban.

    1992-11-01

    Abortion has been illegal in Ireland since 1861. This position was written into the national Constitution in 1963 and reconfirmed by referendum in 1983. Contraception is also illegal in the country. The pregnancy of a 14-year old adolescent due to an alleged rape, however, has caused many in Ireland to voice their support for abortion in limited circumstances. Approximately 5000 pregnant women go from Ireland to the United Kingdom annually for abortions. This 14-year old youth also planned to make the crossing, but was blocked from leaving by the Irish police and later by an injunction of the Attorney-General. The Irish Supreme Court upheld the injunction even though the young woman was reportedly contemplating suicide. A national outcry ensued with thousands of demonstrators marching in Dublin to demand the availability of information on abortion and that Irish women be allowed to travel whenever and wherever they desire. 66% of respondents to recent public opinion polls favor abortion in certain circumstances. Ultimately, the Irish Supreme Court reversed their stance to allow pregnant Irish women to travel internationally and gave suicidal Irish women the right to abortions. These decisions were made shortly within the time frame needed for the young lady in question to received a legal abortion in the United Kingdom.

  17. SOCIOECONOMIC VARIATIONS IN INDUCED ABORTION IN TURKEY.

    Ankara, Hasan Giray

    2017-01-01

    This study aimed to identify the levels of, and socioeconomic variations in, income-related inequality in induced abortion among Turkish women. The study included 15,480 ever-married women of reproductive age (15-49) from the 2003 and 2008 waves of the Turkish Demographic and Health Survey. The measured inequalities in abortion levels and their changes over time were decomposed into the percentage contributions of selected socioeconomic factors using ordinary least square analysis and concentration indices were calculated. The inequalities and their first difference (difference in inequalities between 2003 and 2008) were decomposed using the approaches of Wagstaff et al. (2003). Higher socioeconomic characteristics (such as higher levels of wealth and education and better neighbourhood) were found to be associated with higher rates of abortion. Inequality analyses indicated that although deprived women become more familiar with abortion over time, abortion was still more concentrated among affluent women in the 2008 survey. The decomposition analyses suggested that wealth, age, education and level of regional development were the most important contributors to income-related inequality in abortion. Therefore policies that (i) increase the level of wealth and education of deprived women, (ii) develop deprived regions of Turkey, (iii) improve knowledge about family planning and, especially (iv) enhance the accessibility of family planning services for deprived and/or rural women, may be beneficial for reducing socioeconomic variations in abortion in the country.

  18. The Impact of State Abortion Policies on Teen Pregnancy Rates

    Medoff, Marshall

    2010-01-01

    The availability of abortion provides insurance against unwanted pregnancies since abortion is the only birth control method which allows women to avoid an unwanted birth once they are pregnant. Restrictive state abortion policies, which increase the cost of obtaining an abortion, may increase women's incentive to alter their pregnancy avoidance…

  19. Abortion stigma: a reconceptualization of constituents, causes, and consequences.

    Norris, Alison; Bessett, Danielle; Steinberg, Julia R; Kavanaugh, Megan L; De Zordo, Silvia; Becker, Davida

    2011-01-01

    Stigmatization is a deeply contextual, dynamic social process; stigma from abortion is the discrediting of individuals as a result of their association with abortion. Abortion stigma is under-researched and under-theorized, and the few existing studies focus only on women who have had abortions. We build on this work, drawing from the social science literature to describe three groups whom we posit are affected by abortion stigma: Women who have had abortions, individuals who work in facilities that provide abortion, and supporters of women who have had abortions, including partners, family, and friends, as well as abortion researchers and advocates. Although these groups are not homogeneous, some common experiences within the groups--and differences between the groups--help to illuminate how people manage abortion stigma and begin to reveal the roots of this stigma itself. We discuss five reasons why abortion is stigmatized, beginning with the rationale identified by Kumar, Hessini, and Mitchell: The violation of female ideals of sexuality and motherhood. We then suggest additional causes of abortion stigma, including attributing personhood to the fetus, legal restrictions, the idea that abortion is dirty or unhealthy, and the use of stigma as a tool for anti-abortion efforts. Although not exhaustive, these causes of abortion stigma illustrate how it is made manifest for affected groups. Understanding abortion stigma will inform strategies to reduce it, which has direct implications for improving access to care and better health for those whom stigma affects.

  20. Feelings of Well-Being Before and After an Abortion.

    Hittner, Amy

    1987-01-01

    Examined feelings of well-being in 217 women who had abortions. Results suggest that, compared to women who have not had abortions, those who choose abortion feel more negatively. Of women choosing abortion, those who are already mothers are most likely to be depressed and lonely, followed by those from lower educational and socioeconomic…

  1. 21 CFR 884.5050 - Metreurynter-balloon abortion system.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Metreurynter-balloon abortion system. 884.5050... Devices § 884.5050 Metreurynter-balloon abortion system. (a) Identification. A metreurynter-balloon abortion system is a device used to induce abortion. The device is inserted into the uterine...

  2. Selective abortion in Brazil: the anencephaly case.

    Diniz, Debora

    2007-08-01

    This paper discusses the Brazilian Supreme Court ruling on the case of anencephaly. In Brazil, abortion is a crime against the life of a fetus, and selective abortion of non-viable fetuses is prohibited. Following a paradigmatic case discussed by the Brazilian Supreme Court in 2004, the use of abortion was authorized in the case of a fetus with anencephaly. The objective of this paper is to analyze the ethical arguments of the case, in particular the strategy of avoiding the moral status of the fetus, the cornerstone thesis of the Catholic Church.

  3. Psychosocial correlates of delayed decisions to abort.

    Bracken, M B; Kasl, S V

    1976-01-01

    Two samples of women aborting in New York and Connecticut during 1972 and 1973 were studied. In all, six hundred and fifty eight women about to undergo first and second trimester procedures completed a self-administered questionnaire. Items include: demographic, psychosocial and personality parameters, and a detailed review of the decision process leading to abortion. Analyses of the correlates of delay are organized around four components: acknowledgment of pregnancy; seeing a physician ; deciding to abort; and locating a clinic. Other analyses focus on the role of decisional conflict in delay. Methodological issues, implications for educational practice and for theory of decision-making are discussed.

  4. Preventing infective complications relating to induced abortion.

    Mary, Nirmala; Mahmood, Tahir A

    2010-08-01

    Infective complications following induced abortions are still a common cause of morbidity and mortality. This review focusses on defining the strategies to improve care of women seeking an induced abortion and to reduce infective complications. We have considered the evidence for screening and cost-effectiveness for antibiotic prophylaxis. Current evidence suggests that treating all women with prophylactic antibiotics in preference to screening and treating is the most cost-effective way of reducing infective complications following induced abortions. The final strategy to prevent infective complications should be individualized for each region/area depending on the prevalence of organisms causing pelvic infections and the resources available.

  5. Immediate Intrauterine Device Insertion Following Surgical Abortion.

    Patil, Eva; Bednarek, Paula H

    2015-12-01

    Placement of an intrauterine device (IUD) immediately after a first or second trimester surgical abortion is safe and convenient and decreases the risk of repeat unintended pregnancy. Immediate postabortion IUD placement is not recommended in the setting of postprocedure hemorrhage, uterine perforation, infection, or hematometra. Otherwise, there are few contraindications to IUD placement following surgical abortion. Sexually transmitted infection screening should follow US Centers for Disease Control and Prevention guidelines. No additional antibiotics are needed beyond those used for the abortion. Placing immediate postabortion IUDs makes highly-effective long-acting reversible contraception more accessible to women.

  6. Abort Gap Cleaning for LHC Run 2

    Uythoven, Jan [CERN; Boccardi, Andrea [CERN; Bravin, Enrico [CERN; Goddard, Brennan [CERN; Hemelsoet, Georges-Henry [CERN; Höfle, Wolfgang [CERN; Jacquet, Delphine [CERN; Kain, Verena [CERN; Mazzoni, Stefano [CERN; Meddahi, Malika [CERN; Valuch, Daniel [CERN; Gianfelice-Wendt, Eliana [Fermilab

    2014-07-01

    To minimize the beam losses at the moment of an LHC beam dump the 3 μs long abort gap should contain as few particles as possible. Its population can be minimised by abort gap cleaning using the LHC transverse damper system. The LHC Run 1 experience is briefly recalled; changes foreseen for the LHC Run 2 are presented. They include improvements in the observation of the abort gap population and the mechanism to decide if cleaning is required, changes to the hardware of the transverse dampers to reduce the detrimental effect on the luminosity lifetime and proposed changes to the applied cleaning algorithms.

  7. Aborto. Responsabilidad compartida/Abortion. Shared responsibility

    David Ernesto Betancourt

    2010-08-01

    Full Text Available The father and the mother are involved in the act of procreation, therefore in abortion should also be considered is the father figure in some way and not let you load psychological, emotional and physical exclusively women. Similarly, when she decides to have an abortion he is not observed or questioned integral form to family and society to which she belongs, in short, the stigmatization affects only to the woman in question when there are several actors and circumstances that come into the Act of abortion.

  8. Abort Gap Cleaning for LHC Run 2

    Uythoven, J; Bravin, E; Goddard, B; Hemelsoet, GH; Höfle, W; Jacquet, D; Kain, V; Mazzoni, S; Meddahi, M; Valuch, D

    2015-01-01

    To minimise the beam losses at the moment of an LHC beam dump the 3 μs long abort gap should contain as few particles as possible. Its population can be minimised by abort gap cleaning using the LHC transverse damper system. The LHC Run 1 experience is briefly recalled; changes foreseen for the LHC Run 2 are presented. They include improvements in the observation of the abort gap population and the mechanism to decide if cleaning is required, changes to the hardware of the transverse dampers to reduce the detrimental effect on the luminosity lifetime and proposed changes to the applied cleaning algorithms.

  9. Medical Students’ Attitudes toward Abortion Education: Malaysian Perspective

    Nai-peng Tey; Siew-yong Yew; Wah-yun Low; Lela Su'ut; Prachi Renjhen; Huang, M. S. L.; Wen-ting Tong; Siow-li Lai

    2012-01-01

    BACKGROUND: Abortion is a serious public health issue, and it poses high risks to the health and life of women. Yet safe abortion services are not readily available because few doctors are trained to provide such services. Many doctors are unaware of laws pertaining to abortion. This article reports survey findings on Malaysian medical students' attitudes toward abortion education and presents a case for including abortion education in medical schools. METHODS AND RESULTS: A survey on knowled...

  10. Second trimester medical abortion – perceptions and experiences

    Andersson, Inga-Maj

    2015-01-01

    Introduction Second-trimester abortions account for 10 - 15 % of all induced abortions worldwide with a wide variation of permits in different countries. In Sweden, second-trimester abortions account for less than 10 % of the total number of induced abortions. The indication can be fetal or socioeconomic. The medical abortion regimen with mifepristone and misoprostol, is the regimen used in Sweden. The treatment with misoprostol often causes painful contractions, and prophylactic as we...

  11. Therapeutic abortion in California. Effects of septic abortion and maternal mortality.

    Stewart, G K; Goldstein, P J

    1971-04-01

    The impact of the reformed California abortion law, passed in November 1967, is investigated. The law allows interruption of pregnancy in the presence of substantial risk of grave impairment to the mental or physical health of the mother. Septic abortions (complete or incomplete abortion in a patient whose gestation is less than 20 weeks; duration and whose temperature is greater than 100.4 degrees F for more than 4 hours) per 1000 deliveries at San Francisco General Hospital fell from 69 in 1967 to 22 in 1969. The total number of abortions rose from less than 100 per 1000 births in 1968 to more than 250 in 1969. Maternal deaths due to abortion decreased in California per 100,000 live births from 8 to 5 to 3 in 1967, 1968, and 1969. Maternal deaths due to other causes remained relatively fixed in incidence. Maternal deaths have decreased much more markedly in the San Francisco Bay area, where many more therapeutic abortions have been performed, than in the Los Angeles Area, where relatively few therapeutic abortions have been performed. The decrease in septic abortion seems to represent a trend toward decrease in the number of illegal abortions.

  12. Obstetric performance following an induced abortion.

    Lowit, Alison; Bhattacharya, Sohinee; Bhattacharya, Siladitya

    2010-10-01

    Abortion has been legalised in most of the Western world for the past four decades. In areas where abortion practices are legal and easy to access, the risk of short-term complications is very low. As most women requesting induced abortion (IA) are young, potential adverse effects on subsequent reproductive function are important to them. This review investigates obstetric performance following IA and highlights methodological problems associated with research in this area. Some data suggest that IA may be linked with an increased risk of low birth weight, miscarriage and placenta previa but could be protective for pre-eclampsia. Current evidence also suggests an association between IA and pre-term birth. Large prospective cohort studies, which permit meaningful subgroup analyses, are needed to provide definitive answers on outcomes following alternative methods of IA and the impact of gestational age at abortion on future obstetric outcomes.

  13. Constitutional developments in Latin American abortion law.

    Bergallo, Paola; Ramón Michel, Agustina

    2016-11-01

    For most of the 20th Century, restrictive abortion laws were in place in continental Latin America. In recent years, reforms have caused a liberalizing shift, supported by constitutional decisions of the countries' high courts. The present article offers an overview of the turn toward more liberal rules and the resolution of abortion disputes by reference to national constitutions. For such purpose, the main legal changes of abortion laws in the last decade are first surveyed. Landmark decisions of the high courts of Argentina, Bolivia, Colombia, and Mexico are then analyzed. It is shown that courts have accepted the need to balance interests and competing rights to ground less restrictive laws. In doing so, they have articulated limits to protection of fetal interests, and basic ideas of women's dignity, autonomy, and equality. The process of constitutionalization has only just begun. Constitutional judgments are not the last word, but they are important contributions in reinforcing the legality of abortion.

  14. Thatcher condemns attacks on abortion mp.

    1987-12-19

    The Prime Minister, Mrs Margaret Thatcher, has stepped in to condemn a series of violent attacks on Liberal MP David Alton who is trying to reduce the [Illegible word] limit on abortions from 28 to 18 weeks.

  15. Abortions in Texas Dropped Dramatically After Restrictions

    ... an undue burden on women seeking access to abortion care in Texas," said researcher Dr. Daniel Grossman. Grossman is an investigator with the Texas Policy Evaluation Project, which studies the impact of state legislation affecting women's reproductive health. He's ...

  16. When legalising abortion isn’t enough

    2013-01-01

    LSE’s Ernestina Coast is the Principal Investigator on a new research project in Zambia that seeks to establish how investment in abortion services impacts the socio-economic conditions of women and their households.\\ud \\ud

  17. Sex-Selective Abortions to Be Outlawed

    2005-01-01

    China is to outlaw the selective abortion of female fetuses to correct an imbalance in the ratio of boys to girls that has grown since the family planning policy was introduced more than 20 years ago.

  18. Evidence for Parachlamydia in bovine abortions

    Ruhl, S; Casson, N.; Kaiser, C.; Thoma, R; Pospischil, A.; Greub, G; Borel, N.

    2008-01-01

    Bovine abortion of unknown infectious aetiology still remains a major economic problem. In this study, we focused on new possible abortigenic agents such as Parachlamydia acanthamoebae and Waddlia chondrophila. Retrospective samples (n = 235) taken from late-term abortions in cattle were investigated by real-time diagnostic PCR for Chlamydiaceae, rachlamydia spp. and Waddlia spp., respectively. Histological sections of cases positive by real-time PCR for any Chlamydia-related agent were furth...

  19. Influential Factors in American Abortion Issue

    裴培

    2015-01-01

    The landmark case Roe v.Wade remains one of the most controversial and essential ones in American history.The divergent opinions on abortion also play a crucial part in American political arena.What factors are influencing the dispute about abortion? This essay will thoroughly discuss the factors: the value of freedom and pro-choice and the consideration on women’s self-development; Contrarily,the firm religious faith and the concerns for women’s healt

  20. Influential Factors in American Abortion Issue

    2015-01-01

    The landmark case Roe v.Wade remains one of the most controversial and essential ones in American history. The divergent opinions on abortion also play a crucial part in American political arena.What factors are influencing the dispute about abortion? This essay will thoroughly discuss the factors:the value of freedom and pro-choice and the consideration on women’s self-development; Contrarily,the firm religious faith and the concerns for women’s health.

  1. Abortion in Vietnam: measurements, puzzles, and concerns.

    Goodkind, D

    1994-01-01

    This report summarizes current knowledge about abortion in Vietnam, drawing upon government statistics, survey data, and fieldwork undertaken by the author in Vietnam throughout 1993 and part of 1994. The official total abortion rate in Vietnam in 1992 was about 2.5 per woman, the highest in Asia and worrisome for a country with a still-high total fertility rate of 3.7 children per woman. Vietnamese provinces exhibited substantial variation in both the rate of abortion and the type of procedures performed. Among the hypotheses explored to explain Vietnam's high rate of abortion are the borrowing of family planning strategies from other poor socialist states where abortion is common; current antinatal population policies that interact with a lack of contraceptive alternatives; and a rise in pregnancies among young and unmarried women in the wake of recent free-market reforms. Because family-size preferences are still declining, abortion rates may continue to increase unless the incidence of unwanted pregnancy can be reduced, a goal that Vietnamese population specialists are seeking to achieve.

  2. Induced abortion and subsequent pregnancy duration

    Zhou, Wei Jin; Sørensen, Henrik Toft; Olsen, Jørn

    1999-01-01

    OBJECTIVE: To examine whether induced abortion influences subsequent pregnancy duration. METHODS: Women who had their first pregnancies during 1980, 1981, and 1982 were identified in three Danish national registries. A total of 15,727 women whose pregnancies were terminated by first-trimester ind......OBJECTIVE: To examine whether induced abortion influences subsequent pregnancy duration. METHODS: Women who had their first pregnancies during 1980, 1981, and 1982 were identified in three Danish national registries. A total of 15,727 women whose pregnancies were terminated by first......-trimester induced abortions were compared with 46,026 whose pregnancies were not terminated by induced abortions. All subsequent pregnancies until 1994 were identified by register linkage. RESULTS: Preterm and post-term singleton live births were more frequent in women with one, two, or more previous induced...... abortions. After adjusting for potential confounders and stratifying by gravidity, the odds ratios of preterm singleton live births in women with one, two, or more previous induced abortions were 1.89 (95% confidence interval [CI] 1.70, 2.11), 2.66 (95% CI 2.09, 3.37), and 2.03 (95% CI 1.29, 3...

  3. Effect of Shoutai Pill on Uterine Decidual Protein Expression of Recurrent Spontaneous Abortion Mice Model%寿胎丸对反复自然流产模型小鼠子宫蜕膜蛋白表达的影响

    雷磊; 李慧芳; 谭展望; 罗蕾; 卢丽丽

    2013-01-01

    目的从分子水平探讨寿胎丸安胎的作用机制。方法 CBA/J×BALB/C建立正常妊娠模型,CBA/J×DBA/2建立复发性流产模型,将复发性流产模型CBA/J×DBA/2孕鼠按怀孕先后顺序随机分为模型组和寿胎丸高、中、低剂量组,从妊娠第1日开始灌胃给药,至孕14 d处死小鼠,采用免疫组化方法检测差异蛋白质热休克蛋白27、α-烯醇化酶、转铁蛋白、膜联蛋白 A2蛋白表达。结果与正常组比较,模型组子宫蜕膜热休克蛋白27、α-烯醇化酶表达明显升高,转铁蛋白、膜联蛋白A2表达明显降低,差异有统计学意义(P<0.01);与模型组比较,寿胎丸高、中、低剂量组蜕膜热休克蛋白27、α-烯醇化酶表达均降低,膜联蛋白A2表达均升高,寿胎丸高剂量组子宫蜕膜转铁蛋白表达升高,差异有统计学意义(P<0.01);寿胎丸中、低剂量组蜕膜转铁蛋白表达差异无统计学意义(P>0.05)。结论寿胎丸通过上述蛋白的表达,从而实现维持妊娠,降低胚胎丢失率,这可能是其安胎的作用机制之一。%Objective To explore the mechanism action of Shoutai Pill in the embryo from the molecular level. Methods The model of normal pregnancy was established with the model of recurrent abortion CBA/J ×DBA/2. The recurrent abortion model CBA/J×DBA/2 in pregnant mice were randomly divided into model group, high-, medium-, low-dose group of Shoutai Pill. From the first day of gestation, mice were given medicine by gavage for 14 d, and then sacrificed. Immunohistochemistry was used to detect differences in protein HSP27,α-enolase, transferrin, annexin A2 protein expression. Results Compared with normal group, decidual HSP27 and α-enolase expression of model group increased significantly, the expression of transferrin and annexin A2 was significantly decreased, with significant differences (P0.05). Conclusion Through the protein expression, Shoutai Pill achieves the maintenance of pregnancy

  4. Cross-cultural attitudes toward abortion--Greeks versus Americans.

    Bahr, Stephen J; Marcos, Anastasios C

    2003-04-01

    Using data from 1,494 Greeks and 1,993 Americans, this study finds that social abortion attitudes are a separate dimension from physical abortion attitudes. According to our structural equation model, abortion attitudes are influenced significantly by religiosity and sexual liberalism. The model explains social abortion attitudes significantly better than physical abortion attitudes. Although the model is applicable to both countries, there are three major differences between Greece and the United States. First, in Greece religiosity has a smaller impact on sexual liberalism, and sexual liberalism has a much weaker impact on both types of abortion attitudes, particularly social abortion attitudes. Second, in Greece religiosity is more strongly related to abortion attitudes than in the United States, particularly to social abortion attitudes. Third, education has a weaker influence in Greece than in the United States.

  5. Management of abortion complications at a rural hospital in Uganda

    Mellerup, Natja; Sørensen, Bjarke Lund; Kuriigamba, Gideon K.

    2015-01-01

    BACKGROUND: Complications of unsafe abortion are a major contributor to maternal deaths in developing countries. This study aimed to evaluate the clinical assessment for life-threatening complications and the following management in women admitted with complications from abortions at a rural...... abortion and by trimester. Actual management was compared to the audit criteria and presented by descriptive statistics. RESULTS: Fifty six per cent of the women were in second trimester. Abortion complications were distributed as follows: 53 % incomplete abortions, 28 % threatened abortions, 12...... % inevitable abortions, 4 % missed abortions and 3 % septic abortions. Only one of 238 cases met all criteria of optimal clinical assessment and management. Thus, vital signs were measured in 3 %, antibiotic criteria was met in 59 % of the cases, intravenous fluid resuscitation was administered to 35...

  6. Unsafe abortion and postabortion care-An overview

    Rasch, Vibeke

    2011-01-01

    Forty percent of the world's women are living in countries with restrictive abortion laws, which prohibit abortion or only allow abortion to protect a woman's life or her physical or mental health. In countries where abortion is restricted, women have to resort to clandestine interventions to have...... an unwanted pregnancy terminated. As a consequence, high rates of unsafe abortion are seen, such as in sub-Saharan Africa where unsafe abortion occurs at rates of 18-39/1 000 women. The circumstances under which women obtain unsafe abortion vary and depend on traditional methods known and type of providers...... present. Health professionals are prone to use instrumental procedures to induce the abortion, whereas traditional providers often make a brew of herbs to be drunk in one or more doses. In countries with restrictive abortion laws, high rates of maternal death must be expected and globally an estimated 66...

  7. Freedom of conscience, professional responsibility, and access to abortion.

    Dresser, R S

    1994-01-01

    The current shortage of US physicians willing to perform induced abortions has created a conflict between women's legal right to access to pregnancy termination and physicians' right to refuse participation in a procedure they regard as morally objectionable. According to a 1993 survey, 84% of US counties (housing 30% of women of reproductive age) had no abortion provider. This situation has been exacerbated by a trend to isolate abortion from other medical procedures; in 1992, only 12% of residency programs in obstetrics and gynecology routinely offered training on first-trimester abortion. Also contributing to physician reluctance to become abortion providers have been the violence, death threats, property damage, and harassment of abortion seekers perpetrated by anti-abortion groups. To ameliorate the abortion access crisis, without intruding on the religious convictions of individual physicians, there must be greater collaboration between professional and community groups. Local community officials and pro-choice supporters are urged to use their influence to protect abortion providers from harassment. Professional organizations should provide both symbolic and practical support, e.g. increased status and remuneration, to physicians who commit to the hardship of abortion provision. Older physicians, most aware of the threat to women's health posed by any erosion of abortion rights, should educate their younger colleagues about the importance of safe abortion. Finally, training on abortion techniques should be integrated into the medical school curriculum and rotations should be established at local abortion clinics.

  8. Medication abortion in missed abortion up to 13 weeks amenorrhoea: a prospective study

    Divya R. Prasad

    2016-11-01

    Conclusions: Medication abortion is a safe and effective method for the termination of missed abortion up to 13 weeks of pregnancy with fewer complications thus reducing the need for surgical methods. [Int J Reprod Contracept Obstet Gynecol 2016; 5(11.000: 3840-3842

  9. Medical Students’ Attitudes toward Abortion Education: Malaysian Perspective

    Tey, Nai-peng; Yew, Siew-yong; Low, Wah-yun; Su’ut, Lela; Renjhen, Prachi; Huang, M. S. L.; Tong, Wen-ting; Lai, Siow-li

    2012-01-01

    Background Abortion is a serious public health issue, and it poses high risks to the health and life of women. Yet safe abortion services are not readily available because few doctors are trained to provide such services. Many doctors are unaware of laws pertaining to abortion. This article reports survey findings on Malaysian medical students’ attitudes toward abortion education and presents a case for including abortion education in medical schools. Methods and Results A survey on knowledge of and attitudes toward abortion among medical students was conducted in two public universities and a private university in Malaysia in 2011. A total of 1,060 students returned the completed questionnaires. The survey covered about 90% of medical students in Years 1, 3, and 5 in the three universities. About 90% of the students wanted more training on the general knowledge and legal aspects of abortion, and pre-and post-abortion counseling. Overall, 75.9% and 81.0% of the students were in favor of including in medical education the training on surgical abortion techniques and medical abortion, respectively. Only 2.4% and 1.7% were opposed to the inclusion of training of these two methods in the curriculum. The remaining respondents were neutral in their stand. Desire for more abortion education was associated with students’ pro-choice index, their intention to provide abortion services in future practice, and year of study. However, students’ attitudes toward abortion were not significantly associated with gender, type of university, or ethnicity. Conclusions Most students wanted more training on abortion. Some students also expressed their intention to provide abortion counseling and services in their future practice. Their desire for more training on abortion should be taken into account in the new curriculum. Abortion education is an important step towards making available safe abortion services to enable women to exercise their reproductive rights. PMID:23300600

  10. Medical students' attitudes toward abortion education: Malaysian perspective.

    Nai-peng Tey

    Full Text Available BACKGROUND: Abortion is a serious public health issue, and it poses high risks to the health and life of women. Yet safe abortion services are not readily available because few doctors are trained to provide such services. Many doctors are unaware of laws pertaining to abortion. This article reports survey findings on Malaysian medical students' attitudes toward abortion education and presents a case for including abortion education in medical schools. METHODS AND RESULTS: A survey on knowledge of and attitudes toward abortion among medical students was conducted in two public universities and a private university in Malaysia in 2011. A total of 1,060 students returned the completed questionnaires. The survey covered about 90% of medical students in Years 1, 3, and 5 in the three universities. About 90% of the students wanted more training on the general knowledge and legal aspects of abortion, and pre-and post-abortion counseling. Overall, 75.9% and 81.0% of the students were in favor of including in medical education the training on surgical abortion techniques and medical abortion, respectively. Only 2.4% and 1.7% were opposed to the inclusion of training of these two methods in the curriculum. The remaining respondents were neutral in their stand. Desire for more abortion education was associated with students' pro-choice index, their intention to provide abortion services in future practice, and year of study. However, students' attitudes toward abortion were not significantly associated with gender, type of university, or ethnicity. CONCLUSIONS: Most students wanted more training on abortion. Some students also expressed their intention to provide abortion counseling and services in their future practice. Their desire for more training on abortion should be taken into account in the new curriculum. Abortion education is an important step towards making available safe abortion services to enable women to exercise their reproductive rights.

  11. Latin American women’s experiences with medical abortion in settings where abortion is legally restricted

    Zamberlin Nina

    2012-12-01

    Full Text Available Abstract Abortion is legally restricted in most of Latin America where 95% of the 4.4 million abortions performed annually are unsafe. Medical abortion (MA refers to the use of a drug or a combination of drugs to terminate pregnancy. Mifepristone followed by misoprostol is the most effective and recommended regime. In settings where mifepristone is not available, misoprostol alone is used. Medical abortion has radically changed abortion practices worldwide, and particularly in legally restricted contexts. In Latin America women have been using misoprostol for self-induced home abortions for over two decades. This article summarizes the findings of a literature review on women’s experiences with medical abortion in Latin American countries where voluntary abortion is illegal. Women’s personal experiences with medical abortion are diverse and vary according to context, age, reproductive history, social and educational level, knowledge about medical abortion, and the physical, emotional, and social circumstances linked to the pregnancy. But most importantly, experiences are determined by whether or not women have the chance to access: 1 a medically supervised abortion in a clandestine clinic or 2 complete and accurate information on medical abortion. Other key factors are access to economic resources and emotional support. Women value the safety and effectiveness of MA as well as the privacy that it allows and the possibility of having their partner, a friend or a person of their choice nearby during the process. Women perceive MA as less painful, easier, safer, more practical, less expensive, more natural and less traumatic than other abortion methods. The fact that it is self-induced and that it avoids surgery are also pointed out as advantages. Main disadvantages identified by women are that MA is painful and takes time to complete. Other negatively evaluated aspects have to do with side effects, prolonged bleeding, the possibility that it

  12. Induction of fetal demise before abortion.

    Diedrich, Justin; Drey, Eleanor

    2010-06-01

    For decades, the induction of fetal demise has been used before both surgical and medical second-trimester abortion. Intracardiac potassium chloride and intrafetal or intra-amniotic digoxin injections are the pharmacologic agents used most often to induce fetal demise. In the last several years, induction of fetal demise has become more common before second-trimester abortion. The only randomized, placebo-controlled trial of induced fetal demise before surgical abortion used a 1 mg injection of intra-amniotic digoxin before surgical abortion at 20-23 weeks' gestation and found no difference in procedure duration, difficulty, estimated blood loss, pain scores or complications between groups. Inducing demise before induction terminations at near viable gestational ages to avoid signs of life at delivery is practiced widely. The role of inducing demise before dilation and evacuation (D&E) remains unclear, except for legal considerations in the United States when an intact delivery is intended. There is a discrepancy between the one published randomized trial that used 1 mg intra-amniotic digoxin that showed no improvement in D&E outcomes and observational studies using different routes, doses and pre-abortion intervals that have made claims for its use. Additional randomized trials might provide clearer evidence upon which to make further recommendations about any role of inducing demise before surgical abortion. At the current time, the Society of Family Planning recommends that pharmacokinetic studies followed by randomized controlled trials be conducted to assess the safety and efficacy of feticidal agents to improve abortion safety.

  13. Recurrent spontaneous multiple pregnancy: a case report

    Shazia Parveen

    2016-09-01

    Full Text Available Multiple gestations are usually iatrogenic like use of assisted reproductive techniques (ART, infertility treatment but it is rare in spontaneous conception. High order multiple pregnancies (HOMPs are major cause of maternal, fetal and neonatal morbidity. Multiple gestations carries 2 complications either abortion in early gestation or a preterm delivery in late pregnancy (more common. Preterm delivery is common (50% and patient usually delivers by 30-32 weeks. Discordance of fetal growth is very common and even more than in twins. Perinatal loss is inversely related to birth weight. The mothers should be counseled about regular ante natal care (ANC check-ups for early identification of multiple pregnancies so that proper care can be given to prolong the gestational age and reduce the complications associated with multiple pregnancies. [Int J Reprod Contracept Obstet Gynecol 2016; 5(9.000: 3208-3209

  14. Spontaneous external gallbladder perforation

    Noeldge, G.; Wimmer, B.; Kirchner, R.

    1981-04-01

    Spontaneous perforation of the gallbladder is one complication of cholelithiasis. There is a greater occurence of free perforation in the peritoneal cavity with bilary pertonitis, followed by the perforation into the stomach, small intestine and colon. A single case of the nowadays rare spontaneous perforation in and through the abdominal wall will be reported. Spontaneous gallbladder perforation appears nearly asymptomatic in its clinical course because of absent biliary peritonitis.

  15. Peritonitis - spontaneous bacterial

    Spontaneous bacterial peritonitis (SBP); Ascites - peritonitis; Cirrhosis - peritonitis ... who are on peritoneal dialysis for kidney failure. Peritonitis may have other causes . These include infection from ...

  16. Evidence for Parachlamydia in bovine abortion.

    Ruhl, Silke; Casson, Nicola; Kaiser, Carmen; Thoma, Ruedi; Pospischil, Andreas; Greub, Gilbert; Borel, Nicole

    2009-03-16

    Bovine abortion of unknown infectious aetiology still remains a major economic problem. In this study, we focused on a new possible abortigenic agent called Parachlamydia acanthamoebae. Retrospective samples (n=235) taken from late-term abortions in cattle were investigated by real-time diagnostic PCR for Chlamydiaceae and Parachlamydia spp., respectively. Histological sections of cases positive by real-time PCR for any Chlamydia-related agent were further examined by immunohistochemistry using specific antibodies. Chlamydophila abortus was detected only in three cases (1.3%) by real-time PCR and ArrayTube Microarray playing a less important role in bovine abortion compared to the situation in small ruminants in Switzerland. By real-time PCR as many as 43 of 235 (18.3%) cases turned out to be positive for Parachlamydia. The presence of Parachlamydia within placental lesions was confirmed in 35 cases (81.4%) by immunohistochemistry. The main histopathological feature in parachlamydial abortion was purulent to necrotizing placentitis (25/43). Parachlamydia should be considered as a new abortigenic agent in Swiss cattle. Since Parachlamydia may be involved in lower respiratory tract infections in humans, bovine abortion material should be handled with care given the possible zoonotic risk.

  17. Abortion in Brazil: legislation, reality and options.

    Guedes, A C

    2000-11-01

    Abortion is illegal in Brazil except when performed to save the woman's life or in cases of rape. This paper gives a brief history of parliamentary and extra-parliamentary efforts to change abortion-related legislation in Brazil in the past 60 years, the contents of some of the 53 bills that have been tabled in that time, the non-governmental stakeholders involved and the debate itself in recent decades. The authorities in Brazil have never assumed full public responsibility for reproductive health care or family planning, let alone legal abortion; the ambivalence of the medical profession is an important obstacle. Most politicians avoid getting involved in the abortion debate, but the majority of bills in the 1990s have favoured less restrictive legislation. Incremental legislative and health service changes could help to improve the situation for women. Advocacy is probably the most important action, to promote an environment conducive to change. Clandestine abortion is a serious public health problem in Brazil, and the inadequacy of family planning services is one of the causes of this problem. The solutions should be made a priority for the Brazilian public health system.

  18. Constructing abortion as a social problem: “Sex selection” and the British abortion debate

    2017-01-01

    Between February 2012 and March 2015, the claim that sex selection abortion was taking place in Britain and that action needed to be taken to stop it dominated debate in Britain about abortion. Situating an analysis in sociological and social psychological approaches to the construction of social problems, particularly those considering “feminised” re-framings of anti-abortion arguments, this paper presents an account of this debate. Based on analysis of media coverage, Parliamentary debate and official documents, we focus on claims about grounds (evidence) made to sustain the case that sex selection abortion is a British social problem and highlight how abortion was problematised in new ways. Perhaps most notable, we argue, was the level of largely unchallenged vilification of abortion doctors and providers, on the grounds that they are both law violators and participants in acts of discrimination and violence against women, especially those of Asian heritage. We draw attention to the role of claims made by feminists in the media and in Parliament about “gendercide” as part of this process and argue that those supportive of access to abortion need to critically assess both this aspect of the events and also consider arguments about the problems of “medical power” in the light of what took place.

  19. Student Nurses View an Abortion Client: Attitude and Context Effects.

    Fischer, Edward H.

    1979-01-01

    Presents two studies of the relationship between student nurses' attitudes and patient perception with regard to abortion. Results indicate that the student nurses' judgments were related to their prevailing attitude toward abortion and to their religiosity. (Author/MA)

  20. Physician opinions concerning legal abortion in Bogotá, Colombia.

    Stanhope, Kaitlyn; Rochat, Roger; Fink, Lauren; Richardson, Kalie; Brack, Chelsey; Comeau, Dawn

    2017-01-19

    Since the decriminalisation of abortion in 2006, women in Colombia have continued to seek clandestine abortions, endangering their health and contributing to maternal mortality and morbidity. The goal of this study was to explore physicians' opinions towards and knowledge about legal abortion in Bogotá, Colombia, and key barriers to the legal abortion access. We conducted 13 key informant interviews followed by a survey with a probability sample of 49 doctors working in public hospitals in Bogotá. Interview and survey data showed lack of technical experience in the provision of abortion and nuanced opinions towards its practice. Key informants described ignorance and lack of abortion training in medical schools as key barriers to provision. In the survey, 16/49 respondents had performed an abortion, 24/49 had referred a woman for an abortion and only 33/49 showed correct knowledge of the law.

  1. Uterine contraction induced by Tanzanian plants used to induce abortion

    Nikolajsen, Tine; Nielsen, Frank; Rasch, Vibeke

    2011-01-01

    Women in Tanzania use plants to induce abortion. It is not known whether the plants have an effect.......Women in Tanzania use plants to induce abortion. It is not known whether the plants have an effect....

  2. Induced abortion and placenta complications in the subsequent pregnancy

    Zhou, Wei Jin; Nielsen, Gunnar Lauge; Larsen, Helle

    2001-01-01

    Background. To study the risk of placenta complications following an induced abortion as a function of the interpregnancy interval. Methods. This study is based on three Danish national registries; the Medical Birth Registry, the Hospital Discharge Registry, and the Induced Abortion Registry. All...... primigravida women from 1980 to 1982 were identified in these three registries. A total of 15,727 women who terminated the pregnancy with a first trimester induced abortion were selected to the abortion cohort, and 46,026 women who did not terminate the pregnancy with an induced abortion constituted...... or the Medical Birth Registry records. Results. A slightly higher risk of placenta complications following an abortion was found. Retained placenta occurred more frequently in women with one, two or more previous abortions, compared with women without any previous abortion of similar gravidity. Adjusting...

  3. Pregnancy Choices: Raising the Baby, Adoption, and Abortion

    ... PREGNANCY Pregnancy Choices: Raising the Baby, Adoption, and Abortion • What are my options if I find out ... is financial help available? • If I am considering abortion, what should I know about my state’s laws? • ...

  4. Ethical considerations on methods used in abortions.

    Kluge, Eike-Henner W

    2015-03-01

    There is a fundamental inconsistency in Western society's treatment of non-human animals on the one hand, and of human foetuses on the other. While most Western countries allow the butchering of animals and their use in experimentation, this must occur under carefully controlled conditions that are intended to minimize their pain and suffering as much as possible. At the same time, most Western countries permit various abortion methods without similar concerns for the developing fetus. The only criteria for deciding which abortion method is used centre in the stage of the pregnancy, the size of the fetus, the health of the pregnant woman and the physician's preference. This is out of step with the underlying ethos of animal cruelty legislation, cannot be justified ethically and should be rectified by adjusting abortion methods to the capacity of the fetus to experience nociception and/or pain.

  5. The politics of abortion and contraception

    Drezgić Rada

    2004-01-01

    Full Text Available In this article the author challenges several dominant positions that are relevant for understanding demographic trends and contraceptive practices as well as their mutual relationship. First, the author rejects the assumed direct connection between high abortion rates and low fertility. Second, the author challenges the thesis according to which abortions come about because of the lack of contraception and proposes that high abortion rates result from failing contraception i.e. from high failing rates of coitus interruptus which is a preferred method of birth control by men and women in Serbia. Finally, the author argues that giving control over reproductive risk to men does not make women passive victims of male domination. Rather women are, it is argued, active agents in reproducing hegemonic gender roles and relations. In addition, the author shows how gender power relations formed at the micro level may be consequential for macro level politics.

  6. Spontaneous intracranial hypotension.

    Fullam, L

    2012-01-31

    INTRODUCTION: Spontaneous\\/primary intracranial hypotension is characterised by orthostatic headache and is associated with characteristic magnetic resonance imaging findings. CASE REPORT: We present a case report of a patient with typical symptoms and classical radiological images. DISCUSSION: Spontaneous intracranial hypotension is an under-recognised cause of headache and can be diagnosed by history of typical orthostatic headache and findings on MRI brain.

  7. Abortion laws in African Commonwealth countries.

    Cook, R J; Dickens, B M

    1981-01-01

    This paper provides an overview of the range of current (1981) abortion laws in the African Commonwealth countries, traces the origins of the laws to their colonial predecessors, and discusses legal reform that would positively provide for legal termination of pregnancy. The authors claim that the range of these laws demonstrates an evolution that leads from customary/common law (Lesotho and Swaziland) to basic law (Botswana, The Gambia, Malawi, Mauritius, Nigeria's Northern States and Seychelles) to developed law (Ghana, Kenya, Nigeria's Southern States, Sierra Leone, and Uganda), and, finally, to advanced law (Zambia and Zimbabwe). The authors call for treating abortion as an issue of health and welfare as opposed to one of crime and punishment. Since most of the basic law de jure is treated and administered as developed law de facto, the authors suggest decriminalizing abortion and propose ways in which to reform the law: clarifying existing law; liberalizing existing law to allow abortion based upon certain indications; limiting/removing women's criminal liability for seeking an abortion; allowing hindsight contraception; protecting providers treating women in good faith; publishing recommended fees for services to protect poor women; protecting providers who treat women with incomplete abortion; and punishing providers who fail to provide care to women in need, with the exception of those seeking protection under a conscience clause. The authors also suggest clarifying the means by which health services involving pregnancy termination may be delivered, including: clarification of the qualifications of practitioners who may treat women; specification of the facilities that may treat women, perhaps broken down by gestational duration of the pregnancy; specifying gestational limits during which the procedure can be performed; clarifying approval procedures and consents; and allowing for conscientious objections to performing the procedure.

  8. Catholic options in the abortion debate.

    Maguire, D C

    1990-01-01

    The little-known Roman Catholic theological doctrine of probabilism, an ethical system explicated in all manuals of moral theology, is explained using as an example the dilemma of abortion. Probabilism is based on the notion that a doubtful moral obligation may not be imposed as though it were certain. "Ubi dubium, ibi libertas," means where there is doubt, there is freedom. There are 2 types of moral probability, intrinsic probability, where the individual, without the help of moral theologians, perceives the inapplicability of a particular moral teaching; and extrinsic probability, which involves reliance on the findings of 5 or 6 reputable moral theologians, who may hold a liberal view. Probabilism implies a reasonable doubt, and one's reasons must be cogent, but not necessarily conclusive. Today's abortion debate is an example of a respectable debate, where the liberal view has been endorsed by a number of reputable religious or other humanitarian bodies that in some cases abortion is not always immoral. Other examples in history are the view once taught by the church that taking interest on loans was immoral, that depriving slaves and women of civil rights on non-Catholics of religious or political freedom was moral. For today's legislators, there is a precedent throughout theological history for the state permitting an evil: both St. Augustine and St. Thomas Aquinas wrote that prostitution, although evil, should not be outlawed, because worse evils would occur with prohibition. Legislators who personally find abortion always immoral can support a Roe V. Wade decision because 1) it does not require anyone to have an abortion, and 2) the abortion debate, among Catholics, and non-Catholics is not settled.

  9. Legal, Social and Psycho-Medical Effects of Abortion

    2012-01-01

    This work deals with the relationship between induced abortion and mental health with a special focus on the area of political controversy.  This article explores the historical background of the abortion and its legislative implications in Europe with special reference to Bosnia and Herzegovina. This work is based on etnographich, analitical and historical aproaches. It explains abortion in medical terms and analyzes the psychological effects of the abortion. This is a significant and challa...

  10. Abortion and women's roles in society: opinions from Tlaxcala, Mexico

    2010-01-01

    OBJECTIVE: We aim to assess the opinions of Mexicans in the state of Tlaxcala on abortion and other topics concerning women's reproductive health and status in society. MATERIAL AND METHODS: We summarize opinions on abortion and women's roles in society and perform logit regressions to assess characteristics correlated with support for abortion rights. RESULTS: A majority of respondents were against a woman's right to abortion when asked generally, but when asked about specific circumstances,...

  11. Nursing care according to women in abortion situations

    MARIUTTI, Mariana Gondim; Almeida, Ana Maria; PANOBIANCO, Marislei Sanches

    2007-01-01

    This qualitative study aimed to understand how women having an abortion experience the nursing care they receive. The statements of 13 hospitalized women were analyzed through content analysis. The central category "Nursing care experienced in situations of abortion" was constituted from 4 subcategories: care centered in physical needs; fear of judgment in abortion situations; legal aspects defining care; the need for support in abortion situations. These women identified nursing care as base...

  12. Policies Affect Preferences: Evidence from Random Variation in Abortion Jurisprudence

    2016-01-01

    Whether policies shift preferences is relevant to policy design. We exploit the random assignment of U.S. federal judges creating geographically local precedent and the fact that judges’ politics, religion, and race predict decision-making in abortion jurisprudence. Instrumenting for abortion jurisprudence with exogenous judicial characteristics, we estimate the impact of abortion jurisprudence on state laws, campaign donations, and abortion attitudes. We verify information transmission in th...

  13. Post-Abortion Syndrome: A Critical Review of the Literature

    2013-01-01

    Background and Aim Unwanted pregnancy and abortion are common life events, with an estimated 1 in 5 women experiencing an abortion within their lifetime. Although abortion itself is a relatively minor, safe procedure with minimal physical impact, controversy exists regarding the psychological risks associated with the termination of a pregnancy. A key argument within this debate is whether or not there is such a phenomenon as post-abortion syndrome. Therefore, this study aimed to examine t...

  14. Factors affecting attitudes towards medical abortion in Lithuania

    Lazarus, Jeff; Nielsen, Stine; Jakubcionyte, Rita

    2006-01-01

    Surgical abortion in Lithuania is governed by a 1994 ministerial decree that made it legal for any woman 16 or older. This article seeks to determine the key demographic factors in Lithuanian attitudes towards medical abortion, which is currently not legal.......Surgical abortion in Lithuania is governed by a 1994 ministerial decree that made it legal for any woman 16 or older. This article seeks to determine the key demographic factors in Lithuanian attitudes towards medical abortion, which is currently not legal....

  15. INFLUENCE OF ELECTROACUPUNCTURE ON ARTIFICIAL ABORTION-INDUCED SIDE EFFECTS

    田丽颖

    2001-01-01

    In the present study, the effect of electroecupuncture (EA) of acupoints of Ren, Spleen and Stomach Meridians on artificial abortion-induced side effects was observed in 100 artificial abortion women. In comparison with 45 artificial abortion women in the control group (who had not accepted EA treatment), EA possessed significant effects in relieving abdominal pain, reducing vaginal bleeding duration, lowering infection rate and infertility rate after artificial abortion operation.

  16. Medical abortion. defining success and categorizing failures

    Rørbye, Christina; Nørgaard, Mogens; Vestermark, Vibeke;

    2003-01-01

    Medical abortion was performed in 461 consecutive women with gestational age LT /= 63 days using a regimen of mifepristone 600 mg followed 2 days later by gemeprost 1 mg vaginally. Success, defined as no surgical intervention, declined from 98.7% after 2 weeks to 94.6% after 15 weeks. The differe......Medical abortion was performed in 461 consecutive women with gestational age LT /= 63 days using a regimen of mifepristone 600 mg followed 2 days later by gemeprost 1 mg vaginally. Success, defined as no surgical intervention, declined from 98.7% after 2 weeks to 94.6% after 15 weeks...

  17. [The decision process in induced abortion].

    Ytterstad, T S; Tollan, A

    1990-06-20

    This study describes the pattern of decision as reported by women undergoing elective abortion. The results are based on interviews with 45 of 67 women admitted to the Department of Obstetrics and Gynecology, University Hospital of Tromsø, during a two month period in 1988. All women had informed, and most often consulted, at least one person before making the decision, usually their partner and/or a female friend. The majority of the persons consulted supported her, whatever her decision. According to the women, they made the women, the final decision themselves. Two women were persuaded by their partner to decide to have an elective abortion.

  18. Abortion and contraceptive practices in eastern Europe.

    Kovács, L

    1997-07-01

    In countries of the CCEE region (Countries of Central and Eastern Europe) the very high incidence of pregnancy termination is characteristic of family planning and the notion 'contraception instead of abortion' has not yet been achieved. The causes and consequences of this unfortunate situation will be reviewed: the reproductive health indicators in the area; the status of contraceptive use and of abortion; the impact of legislation in the different countries; and the efforts to achieve changes. The conclusions of the 'Szeged Declaration' which led to an increase in contraceptive prevalence will be discussed.

  19. [Abortion level in 5 species of Cestrum L. (Solanaceae)].

    Castro Laportte, M; Ruíz Zapata, T

    2001-01-01

    We studied the fitness and abortion levels in five species of genus Cestrum L. (Solanaceae) present in a cloud forest of Parque Nacional Henri Pittier, Venezuela. The seed set is variable and the abortion is higher at flowers-fruits and ovule levels, while the S/O ratio is low. We discuss the possible causes of abortion and seed set in these species.

  20. The Expression of Experience: Code's Critique of Gilligan's Abortion Study.

    Pitt, Alice

    1991-01-01

    Presents a response to Lorraine Code's critique of Carol Gilligan's abortion study. Urges that abortion be read as a socially constructed experience based on more than women's moral decisions. Discusses language and experience to present abortion as an area of contested meaning in historical and ideological constructions of social life. (DK)

  1. 42 CFR 457.475 - Limitations on coverage: Abortions.

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Limitations on coverage: Abortions. 457.475 Section... State Plan Requirements: Coverage and Benefits § 457.475 Limitations on coverage: Abortions. (a) General rule. FFP under title XXI is not available in expenditures for an abortion, or in expenditures for...

  2. The Effect of Religious Membership on Teen Abortion Rates.

    Tomal, Annette

    2001-01-01

    Studied abortion rates among teenagers in 1,024 counties in 18 states that report abortion numbers. Results show that counties with high levels of religious membership were more likely to be in a state with a parental involvement law for teenage abortions. Both religious membership level and a parental involvement law were negatively related to…

  3. 21 CFR 884.5070 - Vacuum abortion system.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Vacuum abortion system. 884.5070 Section 884.5070 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... § 884.5070 Vacuum abortion system. (a) Identification. A vacuum abortion system is a device designed...

  4. Fatal acute spontaneous endometritis resulting from Clostridium sordelli.

    Hogan, S F; Ireland, K

    1989-01-01

    Intrauterine clostridial infections have historically been associated with puerperal sepsis, often subsequent to instrumented abortions. Isolated reports have been associated with a malignant neoplasm or degenerating leiomyoma, most often after instrumentation, radiation therapy, or chemotherapy. In these cases, well-known risk factors or obvious niduses for growth and causation of disease were identified. The authors report a case of fatal spontaneous endometritis resulting from Clostridum sordellii, which, to their knowledge, has not been previously reported in the literature. Characteristics of this rare virulent human pathogen are discussed.

  5. Secondary infertility caused by the retention of fetal bones after an abortion: a case report

    Kramer Hannah MC

    2008-06-01

    Full Text Available Abstract Introduction Unwanted contraception through prolonged retention of fetal bone is a rare cause of secondary infertility. It is usually associated with a history of abortion, either spontaneous or induced. Case presentation We describe a case of intrauterine retention of fetal bone diagnosed 8 years after the termination of a pregnancy. The patient had no complaints of pain, irregular vaginal bleeding or discharge. A hysteroscopy was performed and irregular structures were removed. These fragments were fetal bones, which probably functioned as an intrauterine contraceptive device. After removal of the fetal bone fragments the patient conceived spontaneously within 6 months. Conclusion This case report stresses the importance of taking a thorough history and evaluation of the endometrium by transvaginal ultrasound or hysteroscopy in women with secondary infertility.

  6. Algorithm for Determination of Orion Ascent Abort Mode Achievability

    Tedesco, Mark B.

    2011-01-01

    For human spaceflight missions, a launch vehicle failure poses the challenge of returning the crew safely to earth through environments that are often much more stressful than the nominal mission. Manned spaceflight vehicles require continuous abort capability throughout the ascent trajectory to protect the crew in the event of a failure of the launch vehicle. To provide continuous abort coverage during the ascent trajectory, different types of Orion abort modes have been developed. If a launch vehicle failure occurs, the crew must be able to quickly and accurately determine the appropriate abort mode to execute. Early in the ascent, while the Launch Abort System (LAS) is attached, abort mode selection is trivial, and any failures will result in a LAS abort. For failures after LAS jettison, the Service Module (SM) effectors are employed to perform abort maneuvers. Several different SM abort mode options are available depending on the current vehicle location and energy state. During this region of flight the selection of the abort mode that maximizes the survivability of the crew becomes non-trivial. To provide the most accurate and timely information to the crew and the onboard abort decision logic, on-board algorithms have been developed to propagate the abort trajectories based on the current launch vehicle performance and to predict the current abort capability of the Orion vehicle. This paper will provide an overview of the algorithm architecture for determining abort achievability as well as the scalar integration scheme that makes the onboard computation possible. Extension of the algorithm to assessing abort coverage impacts from Orion design modifications and launch vehicle trajectory modifications is also presented.

  7. Aborto no Brasil: um enfoque demográfico Abortion in Brazil: a demographic approach

    José Guilherme Cecatti

    2010-03-01

    induced abortion reported by a sample of Brazilian women interviewed in the National Demographic Health Survey of 1996. METHODS: this was a secondary analysis of the Brazilian DHS-96 database, with information from interviews with a representative sample of 12,612 women about their reproductive life, focusing on the prevalence of spontaneous and induced abortion in the last five years and the associated factors for the various regions of the country and for Brazil as a whole. The sampling method was implemented with a strategy selection in two stages, one for the households and the other for women. The prevalence of spontaneous and induced abortion was estimated for Brazil and regions, and the socio-demographic characteristics of the women were analyzed as a function of the abortion's experience. A multinomial regression model analysis was used for the identification of factors independently associated with both types of abortion; their OR and respective 95% CI are reported. RESULTS: the prevalence of reported spontaneous abortion was 14% and the prevalence of induced abortion was 2.4% for the country as a whole. The state with the highest prevalence of induced abortion was Rio de Janeiro with 6.5%, followed by the Northeast region with 3.1%. The places with the lowest prevalence were the state of São Paulo and the South region. Both spontaneous and induced abortion showed higher prevalences with increasing age of the women studied. Being from the urban area (OR=1.5; 95%CI=1.0-2.3, having had more than one live child (OR=2.2; 95%CI=1.5-3.2 and being non-white (OR=1.4; 95%CI=1.0-1.8 were the main risk factors for induced abortion. CONCLUSIONS: the non-modifiable risk factors for induced abortion identified in this study indicate the need for improvement of educational and contraceptive actions, with priority for these specific demographic groups.

  8. Abortion Legalization and Childbearing in Mexico.

    Gutiérrez Vázquez, Edith Y; Parrado, Emilio A

    2016-06-01

    In 2007 abortion was legalized in the Federal District of Mexico, making it the largest jurisdiction in Latin America, outside of Cuba, to allow women to have abortions on request during the first trimester of pregnancy. While the implications of the law for women's health and maternal mortality have been investigated, its potential association with fertility behavior has yet to be assessed. We examine metropolitan-area differences in overall and parity-specific childbearing, as well as the age pattern of childbearing between 2000 and 2010 to identify the contribution of abortion legalization to fertility in Mexico. Our statistical specification applies difference-in-difference regression methods that control for concomitant changes in other socioeconomic predictors of fertility to assess the differential influence of the law across age groups. In addition, we account for prior fertility levels and change to better separate the effect of the law from preceding trends. Overall, the evidence suggests a systematic association between abortion legalization and fertility. The law appears to have contributed to lower fertility in Mexico City compared to other metropolitan areas and prior trends. The influence is mostly visible among women aged 20-34 in connection with the transition to first and second child, with limited impact on teenage fertility. There is some evidence that its effect might be diffusing to the Greater Mexico City Metropolitan area.

  9. The Psychological and Emotional Effects of Abortion.

    Arafat, Ibtihaj S.; Chireau, Ruby M.

    The purpose of this study was to investigate the psychological and emotional effects of abortion on women who terminated their pregnancies for social, economic, or personal reasons. These effects were determined, in part, by an analysis of the woman's concept of self, the external support given, and the various coping mechanisms utilized in the…

  10. Medical abortion. defining success and categorizing failures

    Rørbye, Christina; Nørgaard, Mogens; Vestermark, Vibeke

    2003-01-01

    Medical abortion was performed in 461 consecutive women with gestational age LT /= 63 days using a regimen of mifepristone 600 mg followed 2 days later by gemeprost 1 mg vaginally. Success, defined as no surgical intervention, declined from 98.7% after 2 weeks to 94.6% after 15 weeks. The differe......Medical abortion was performed in 461 consecutive women with gestational age LT /= 63 days using a regimen of mifepristone 600 mg followed 2 days later by gemeprost 1 mg vaginally. Success, defined as no surgical intervention, declined from 98.7% after 2 weeks to 94.6% after 15 weeks....... The difference in short- and long-term success rates increased with increasing gestational age. The majority of failures (76%) were diagnosed more than 2 weeks after initiation of the abortion. At a 2-week follow-up visit, the women who turned out to be failures had a larger endometrial width, higher beta......-hCG values and smaller reductions of beta-hCG than those treated successfully. To optimize comparison of success rates after different medical abortion regimens, we suggest that the criteria for success are stated clearly, that the success rates are stratified according to gestational age...

  11. Abortion Services and Military Medical Facilities

    2010-07-08

    general.83 However, the Senate agreed, subject to certain limitations, to consider legislation, S. 1104,84 “to provide for parental involvement in...Senators Frist and Brownback), would “provide for parental involvement in the performance of abortions for dependent children of members of the Armed

  12. Spiral kicker for the beam abort system

    Martin, R.L.

    1983-01-01

    A brief study was carried out to determine the feasibility of a special kicker to produce a damped spiral beam at the beam dump for the beam abort system. There appears to be no problem with realizing this concept at a reasonably low cost.

  13. Women's hidden transcripts about abortion in Brazil.

    Nations, M K; Misago, C; Fonseca, W; Correia, L L; Campbell, O M

    1997-06-01

    Two folk medical conditions, "delayed" (atrasada) and "suspended" (suspendida) menstruation, are described as perceived by poor Brazilian women in Northeast Brazil. Culturally prescribed methods to "regulate" these conditions and provoke menstrual bleeding are also described, including ingesting herbal remedies, patent drugs, and modern pharmaceuticals. The ingestion of such self-administered remedies is facilitated by the cognitive ambiguity, euphemisms, folklore, etc., which surround conception and gestation. The authors argue that the ethnomedical conditions of "delayed" and "suspended" menstruation and subsequent menstrual regulation are part of the "hidden reproductive transcript" of poor and powerless Brazilian women. Through popular culture, they voice their collective dissent to the official, public opinion about the illegality and immorality of induced abortion and the chronic lack of family planning services in Northeast Brazil. While many health professionals consider women's explanations of menstrual regulation as a "cover-up" for self-induced abortions, such popular justifications may represent either an unconscious or artful manipulation of hegemonic, anti-abortion ideology expressed in prudent, unobtrusive and veiled ways. The development of safer abortion alternatives should consider women's hidden reproductive transcripts.

  14. Abortion Legalization and Life-Cycle Fertility

    Ananat, Elizabeth Oltmans; Gruber, Jonathan; Levine, Phillip

    2007-01-01

    The early-1970s abortion legalization led to a significant drop in fertility. We investigate whether this decline represented a delay in births or a permanent reduction in fertility. We combine Census and Vital Statistics data to compare the lifetime fertility of women born in early-legalizing states, whose peak childbearing years occurred in the…

  15. Motherhood and induced abortion among teenagers

    Christoffersen, Mogens

    The study investigates the social background of teenagers before being teenage mothers or having an induced abortion. A discrete-time proportional hazard modelling was used to analyse the longitudinal observations of population-based registers covering all children born in Denmark in 1966...

  16. Review on abort trajectory for manned lunar landing mission

    2010-01-01

    Abort trajectory is a passage that ensures the astronauts to return safely to the earth when an emergency occurs. Firstly,the essential elements of mission abort are analyzed entirely based on summarizing the existing studies. Then,abort trajectory requirement and rational selection for different flight phases of typical manned lunar mission are discussed specifically. Considering a trade-off between the two primary constrains of an abort,the return time of flight and energy requirement,a general optimizing method for mission abort is proposed. Finally,some suggestions are given for China’s future manned lunar landing mission.

  17. Why don’t humanitarian organizations provide safe abortion services?

    McGinn, Therese; Casey, Sara E

    2016-01-01

    Background Although sexual and reproductive health services have become more available in humanitarian settings over the last decade, safe abortion services are still rarely provided. The authors’ observations suggest that four reasons are typically given for this gap: ‘There’s no need’; ‘Abortion is too complicated to provide in crises’; ‘Donors don’t fund abortion services’; and ‘Abortion is illegal’. Discussion However, each of these reasons is based on false premises. Unsafe abortion is a...

  18. An alternate mechanism of abortive release marked by the formation of very long abortive transcripts.

    Chander, Monica; Austin, Karyn M; Aye-Han, Nwe-Nwe; Sircar, Piya; Hsu, Lilian M

    2007-11-01

    The Esigma70-dependent N25 promoter is rate-limited at promoter escape. Here, RNA polymerase repeatedly initiates and aborts transcription, giving rise to a ladder of short RNAs 2-11 nucleotides long. Certain mutations in the initial transcribed sequence (ITS) of N25 lengthen the abortive initiation program, resulting in the release of very long abortive transcripts (VLATs) 16-19 nucleotides long. This phenomenon is completely dependent on sequences within the first 20 bases of the ITS since altering sequences downstream of +20 has no effect on their formation. VLAT formation also requires strong interactions between RNA polymerase and the promoter. Mutations that change the -35 and -10 hexamers and the intervening 17 base pair spacer away from consensus decrease the probability of aborting at positions +16 to +19. An unusual characteristic of the VLATs is their undiminished levels in the presence of GreB, which rescues abortive RNAs (abortive release at VLAT positions.

  19. Psychology Consequences of Abortion Among The Post Abortion Care Seeking Women in Tehran

    Abolghasem Pourreza

    2011-01-01

    Full Text Available "nObjective: abortion either medical or criminal has distinctive physical, social, and psychological side effects. Detecting types and frequent psychological side effects of abortion among post abortion care seeking women in Tehran was the main objective of the present study. "n Method: 278 women of reproductive age (15-49 interviewed as study population. Response rate was 93/8. Data collected through a questionnaire with 2 parts meeting broad socio-economic characteristics of the respondents and health- related abortion consequences. Tehran hospitals were the site of study. "nResults: The results revealed that at least one-third of the respondents have experienced psychological side effects. Depression, worrying about not being able to conceive again and abnormal eating behaviors were reported as dominant psychological consequences of abortion among the respondents. Decreased self-esteem, nightmare, guilt, and regret with 43.7%, 39.5%, 37.5%, and 33.3% prevalence rates have been placed in the lower status, respectively. "nConclusion: Psychological consequences of abortion have considerably been neglected. Several barriers made findings limited. Different types of psychological side effects, however, experienced by the study population require more intensive attention because of chronic characteristic of psychological disorders, and women's health impact on family and population health.

  20. Measuring stigma among abortion providers: assessing the Abortion Provider Stigma Survey instrument.

    Martin, Lisa A; Debbink, Michelle; Hassinger, Jane; Youatt, Emily; Eagen-Torkko, Meghan; Harris, Lisa H

    2014-01-01

    We explored the psychometric properties of 15 survey questions that assessed abortion providers' perceptions of stigma and its impact on providers' professional and personal lives referred to as the Abortion Provider Stigma Survey (APSS). We administered the survey to a sample of abortion providers recruited for the Providers' Share Workshop (N = 55). We then completed analyses using Stata SE/12.0. Exploratory factor analysis, which resulted in 13 retained items and identified three subscales: disclosure management, resistance and resilience, and discrimination. Stigma was salient in abortion provider's lives: they identified difficulties surrounding disclosure (66%) and felt unappreciated by society (89%). Simultaneously, workers felt they made a positive contribution to society (92%) and took pride in their work (98%). Paired t-test analyses of the pre- and post-Workshop APSS scores showed no changes in the total score. However, the Disclosure Management subscale scores were significantly lower (indicating decreased stigma) for two subgroups of participants: those over the age of 30 and those with children. This analysis is a promising first step in the development of a quantitative tool for capturing abortion providers' experiences of and responses to pervasive abortion stigma.

  1. Comparison of Two Recent Launch Abort Platforms

    Dittemore, Gary D.; Harding, Adam

    2011-01-01

    The development of new and safer manned space vehicles is a top priority at NASA. Recently two different approaches of how to accomplish this mission of keeping astronauts safe was successfully demonstrated. With work already underway on an Apollo-like launch abort system for the Orion Crew Exploration Vehicle (CEV), an alternative design concept named the Max Launch Abort System, or MLAS, was developed as a parallel effort. The Orion system, managed by the Constellation office, is based on the design of a single solid launch abort motor in a tower positioned above the capsule. The MLAS design takes a different approach placing the solid launch abort motor underneath the capsule. This effort was led by the NASA Engineering and Safety Center (NESC). Both escape systems were designed with the Ares I Rocket as the launch vehicle and had the same primary requirement to safely propel a crew module away from any emergency event either on the launch pad or during accent. Beyond these two parameters, there was little else in common between the two projects, except that they both concluded in successful launches that will further promote the development of crew launch abort systems. A comparison of these projects from the standpoint of technical requirements; program management and flight test objectives will be done to highlight the synergistic lessons learned by two engineers who worked on each program. This comparison will demonstrate how the scope of the project architecture and management involvement in innovation should be tailored to meet the specific needs of the system under development.

  2. Herbal infusions used for induced abortion.

    Ciganda, Carmen; Laborde, Amalia

    2003-01-01

    Plants and herbs have been used to induce abortions but there is very little published information describing the commonly used ones. The purpose of this report is to describe the herbal products used to induce abortions, and to enhance awareness and understanding of their toxic effects. A descriptive retrospective survey was conducted on the calls received by the Montevideo Poison Centre between 1986 and 1999 concerning the ingestion of herbal infusions with abortive intent. A total of 86 cases involving 30 different plant species were identified. The species most frequently involved were ruda (Ruta chalepensis/graveolens), cola de quirquincho (Lycopodium saururus), parsley (Petroselinum hortense), and an over-the-counter herbal product named Carachipita. The components of Carachipita are pennyroyal (Mentha pulegium), yerba de la perdiz (Margiricarpus pinnatus), oregano (Origanum vulgare), and guaycuri (Statice brasiliensis). Abortion occurred in 23 cases after the ingestion of parsley, ruda, Carachipita, celery, Cedron, francisco alvarez, floripon, espina colorada. Out of the 23 cases, 15 involved the only the ingestion of plants, 4 cases used injected drugs (presumably hormones), and in 4 cases there was associated self-inflicted instrumental manipulation. Multiple organ system failure occurred in those patients who had ingested ruda (alone or in combination with parsley or fennel), Carachipita, arnica, or bardana. Deaths occurred in one case of Carachipita ingestion and in 4 cases of ruda ingestion (2 cases of ruda alone, 2 cases of ruda with parsley and fennel). Self-inflicted instrumental manipulations were found in 4 of the patients with multiple organ system failure and in one of those who died. The results of this report are not conclusive, but it appears that the ingestion of plants to induce abortion involves the risk of severe morbidity and mortality.

  3. Unsafe Abortion- A Tragic Saga of Maternal Suffering

    M C Regmi

    2010-03-01

    Full Text Available INTRODUCTION: Unsafe abortion is a significant cause of maternal morbidity and mortality in developing countries despite provision of adequate care and legalization of abortion. The aim of this study was to find out the contribution of unsafe abortion in maternal mortality and its other consequences. METHODS: A retrospective study was carried out in the Department of Obstetrics and Gynecology in BPKIHS between 2005 April to 2008 September analyzing all the unsafe abortion related admissions. RESULTS: There were 70 unsafe abortion patients. Majority of them (52.8% were of high grade. Most of them recovered but there were total 8maternal deaths. CONCLUSIONS: Unsafe abortion is still a significant medical and social problem even in post legalization era of this country. Keywords: abortion, legalization, maternal death, unsafe.

  4. Induced first-trimester abortion and risk of mental disorder

    Munk-Olsen, Trine; Laursen, Thomas Munk; Pedersen, Carsten B

    2011-01-01

    Background Concern has been expressed about potential harm to women's mental health in association with having an induced abortion, but it remains unclear whether induced abortion is associated with an increased risk of subsequent psychiatric problems. Methods We conducted a population-based cohort......-trimester induced abortion or a first childbirth during that period. We estimated the rates of first-time psychiatric contact (an inpatient admission or outpatient visit) for any type of mental disorder within the 12 months after the abortion or childbirth as compared with the 9-month period preceding the event....... Results The incidence rates of first psychiatric contact per 1000 person-years among girls and women who had a first abortion were 14.6 (95% confidence interval [CI], 13.7 to 15.6) before abortion and 15.2 (95% CI, 14.4 to 16.1) after abortion. The corresponding rates among girls and women who had a first...

  5. Spontaneous Rupture of Pyometra

    Fatemeh Mallah; Tahere Eftekhar; Mohammad Naghavi-Behzad

    2013-01-01

    Spontaneous perforation is a very rare complication of pyometra. The clinical findings of perforated pyometra are similar to perforation of the gastrointestinal tract and other causes of acute abdomen. In most cases, a correct and definite diagnosis can be made only by laparotomy. We report two cases of diffuse peritonitis caused by spontaneous perforated pyometra. The first case is a 78-year-old woman with abdominal pain for which laparotomy was performed because of suspected incarcerated he...

  6. Gynecologists and the abortion issue in Serbia

    Rašević Mirjana

    2007-01-01

    Full Text Available Traditional inefficient contraception, incorporated to a large extent in the system of values, has become a natural part of sexual relations in Serbia and represents a rational preventive choice from the individual standpoint. However, when pregnancy is unwanted or cannot be accepted out of any reasons abortion is used as a resort. For this reason there is a long history of a large number of abortions in Serbia. Research findings in our country identify the following, as the most important factors for not accepting modern values in this sphere: traditional contraception and abortion have a firm social confirmation; there is a trans-generational transfer of psychological resistance towards the use of combined oral contraception pills and intrauterine devices; sexual education has never become a natural way of growing up in the family, nor is a constituent part of school programs and that distinct obstacles of various nature exist regarding contraception availability. A developed network of various types of family planning counseling is an important determinant of the accessibility of contraceptive means and methods. There are, however, numerous conditions which have to be fulfilled in order for the contraception counseling services to function properly. Among them, motivated personnel who acquired general and specific knowledge for work in this field are an especially important prerequisite. This theoretical assumption opens the question -whether gynecologists represent an important factor of slow transition of birth control in Serbia? We searched for the answer in the research analyses obtained through two in-depth surveys which either had to do with this theme or tried to determine the knowledge, attitude and practice of gynecologists. The first research regarding the determination of the causes for a large number of abortions in our country, was directed towards women who decided on abortion. Gynecologists were the target group in the second

  7. Abortamento espontâneo e provocado: ansiedade, depressão e culpa Spountaneous and induced abortion: anxiety, depression and guilty

    Gláucia Rosana Guerra Benute

    2009-01-01

    Full Text Available OBJETIVOS: Caracterizar a população que sofreu abortamento; investigar a existência de ansiedade e depressão; verificar se existe ou não sentimento de culpa após o abortamento e comparar os resultados entre mulheres que sofreram abortamento espontâneo e as que provocaram-no. MÉTODOS: 50 mulheres com abortamento espontâneo e 50 com provocado foram entrevistadas 30 dias após o abortamento. Foi realizada entrevista com questões abertas e fechadas e aplicada a escala Hospital Anxiety and depression. RESULTADOS: As mulheres que viveram o abortamento espontâneo encontram-se mais culpadas (30% que as que provocaram-no (18%. No entanto, as mulheres que provocaram o abortamento encontraram-se mais ansiosas (média de 11 e mais deprimidas (média de 8,3 que as mulheres que viveram abortamento espontâneo (médias de 8,7 e 6,1; respectivamente, pBACKGROUND: Pregnancy has a symbolic meaning for each woman. It varies according to personality structure and is related to women's previous life experiences. OBJECTIVES: the aim was to characterize the women that suffered abortion, asking about anxiety and depression, looking for guilty feelings after abortion, and to compare results between women who suffered spontaneous abortion and those who had intentional abortion. METHODS: fifty women with spontaneous and fifty with induced abortion were interviewed 30 days after the procedure. A semistructured questionnaire with open and closed-end questions and Hospital Anxiety and Depression Scale were administered. RESULTS: woman who induced abortion revealed to be more anxious (mean 11 and depressed (mean 8.3 than woman with spontaneous abortion (means 8.7 and 6.1 respectively, p<0.05. CONCLUSIONS: women who presented induced abortion were more anxious and depressed, as shown by later life events, full of problematic feelings and the need fort sychological support.

  8. Exploring the pathways of unsafe abortion in Madhya Pradesh, India.

    Banerjee, Sushanta K; Andersen, Kathryn

    2012-01-01

    Nearly 40 years after enactment of the Medical Termination of Pregnancy Act of 1971, unsafe abortion continues to be a neglected women's health issue in India. This prospective study of women presenting for post-abortion care in 10 selected hospitals in Madhya Pradesh, India, aimed to understand the incidence, types and severity of post-abortion complications, probable causes of complications and consequences to women in terms of hospitalisation and incurred costs. Among 1565 women presenting for induced abortion-related services between July and November 2007, 381 women with post-abortion complications consented to participate. Data reveal a high prevalence of post-abortion complications (29%). Approximately half of women originally attempted to induce abortion at home using medication, home-made concoctions or traditional methods. Ninety percent sought care from either qualified (37%) or unqualified providers. More than half of the women were hospitalised as a result of post-abortion complications. This study suggests that supporting access to safely induced abortion services and improving community awareness on legal aspects, safe methods and approved providers are all necessary to reduce morbidity associated with unsafe abortion.

  9. Induced abortion among Brazilian female sex workers: a qualitative study

    Alberto Pereira Madeiro

    2015-02-01

    Full Text Available Prostitutes are vulnerable to unplanned pregnancies and abortions. In Brazil, abortion is a crime and there is no data about unsafe abortions for this population. The study describes how prostitutes perform illegal abortions and the health consequences thereof. Semi-structured interviews with 39 prostitutes from three cities in Brazil with previous induced abortion experience were conducted. Sixty-six abortions, with between one and eight occurrences per woman, were recorded. The majority of the cases resulted from sexual activity with clients. The inconsistent use of condoms with regular clients and the consumption of alcohol during work were indicated as the main causes of unplanned pregnancies. The main method to perform abortion was the intravaginal and oral use of misoprostol, acquired in pharmacies or on the black market. Invasive measures were less frequently reported, however with more serious health complications. The fear of complaint to the police meant that most women do not inform the health team regarding induced abortion. The majority of prostitutes aborted with the use of illegally-acquired misoprostol, ending abortion in a public hospital with infection and hemorrhagic complications. The data indicate the need for a public policy focusing on the reproductive health of prostitutes.

  10. [An opinion survey on abortion in Mexico City].

    Núñez-Fernández, L; Shrader-Cox, E; Benson, J

    1994-01-01

    In view of the lack of information regarding abortion attitudes in Mexico, an abortion opinion survey was conducted in Mexico City among 387 women and 338 men. Respondents were asked if they agreed with a woman's abortion decision under seven different circumstances. Affirmative responses were analyzed by respondents' sociodemographic and reproductive health characteristics and a scale was created to measure respondents' overall attitudes toward abortion. Greatest support was expressed for a woman's right to an abortion, and to abortion in cases of fetal defect, threat to the mother's life, and rape. On the attitudinal scale, however, respondents generally disapproved abortion. Male respondents were more likely than female respondents to support a woman's abortion decision. Males in union, females not in union, respondents over thirty years of age, those with more than primary school education, those with fewer pregnancies, those with no history of child mortality, and those with a history of or experience with abortion, were also more likely to support an abortion decision.

  11. Nurses in abortion care: identifying and managing stress.

    Lipp, Allyson; Fothergill, Anne

    2009-02-01

    The psychological impact of abortion on the women undergoing the procedure is well researched, but little is known about the potential psychological impact on nurses working in abortion care. The proportion of medical abortions in the UK is rising compared to surgical abortions. A recent research study found that being more directly involved in the procedure places more emotional demands on the nurses. This emotional labour required by nurses working in abortion care may increase their stress levels. This paper examines the potential increase in stress in nurses caused by medical abortions. A model of stress comprising stressors, moderators and stress outcomes was used as a framework for this examination. Research on abortion and mental health nursing was applied to managing stress in abortion care; this included coping mechanisms, prevention and intervention strategies. This showed that stress, burnout and coping are important issues in abortion care. On this basis, recommendations for practice have been formulated to inform practice for nurses and managers in abortion care.

  12. Induced abortion among Brazilian female sex workers: a qualitative study.

    Madeiro, Alberto Pereira; Diniz, Debora

    2015-02-01

    Prostitutes are vulnerable to unplanned pregnancies and abortions. In Brazil, abortion is a crime and there is no data about unsafe abortions for this population. The study describes how prostitutes perform illegal abortions and the health consequences thereof. Semi-structured interviews with 39 prostitutes from three cities in Brazil with previous induced abortion experience were conducted. Sixty-six abortions, with between one and eight occurrences per woman, were recorded. The majority of the cases resulted from sexual activity with clients. The inconsistent use of condoms with regular clients and the consumption of alcohol during work were indicated as the main causes of unplanned pregnancies. The main method to perform abortion was the intravaginal and oral use of misoprostol, acquired in pharmacies or on the black market. Invasive measures were less frequently reported, however with more serious health complications. The fear of complaint to the police meant that most women do not inform the health team regarding induced abortion. The majority of prostitutes aborted with the use of illegally-acquired misoprostol, ending abortion in a public hospital with infection and hemorrhagic complications. The data indicate the need for a public policy focusing on the reproductive health of prostitutes.

  13. [The modern indications for abortion (author's transl)].

    Stucki, D

    1980-01-15

    Within the Swiss legal code, somatic and psychiatric indications for interruption of pregnancy are very well indicated and codified. These days, however, only 8% of indications for abortion are based on purely medical reasons; the great majority of indications are "modern", a clear manifestation of a slipping away from classical indications toward a much more liberal intervention which often has nothing to do with the corporal integrity of the mother, but with that of the child, or which simply takes into consideration the future quality of life of everybody involved. This evolution is a reflection of the new role of women in society, and also the result of the recent progresses of the science of neonatology. Such enlarged indications for abortion are accepted by most doctors concerned with these problems, and they include such different reasons as IUD failure, hormonal contraception failure, very young or too old age, exposure to X-rays, divorce and exposure to chemotherapy.

  14. [Psychodiagnostic factors of indication for abortion].

    Blaser, A; Hodel, J

    1975-04-05

    The psychodiagnostic indication for abortion was investigated by means of the MMPI in 251 women with unwanted pregnancy. The results showed: 1. that, independently of the MMPI, positive indications exhibited more obvious psychopathological distrubance than the negative indications; 2. that women with negative indications where in some ways psychologically different from women with wanted pregnancy; 3. that after abortion women with positive indication no longer differed from a group of women with wanted pregnancy, so that the former could be identified as psychologically well adjusted; and 4. comparison between women with unwanted pregnancy and a group of neurotic women showed that both groups are phenomenologically very similar although women with unwanted pregnancy should be diagnosed as "reactive". The results are presented without comment as a basis for the medical and political debate now in progress.

  15. Orion Launch Abort System (LAS) Propulsion on Pad Abort 1 (PA-1)

    Jones, Daniel S.

    2015-01-01

    This presentation provides a concise overview of the highly successful Orion Pad Abort 1 (PA-1) flight test, and the three rocket motors that contributed to this success. The primary purpose of the Orion PA-1 flight was to help certify the Orion Launch Abort System (LAS), which can be utilized in the unlikely event of an emergency on the launchpad or during mission vehicle ascent. The PA-1 test was the first fully integrated flight test of the Orion LAS, one of the primary systems within the Orion Multi-Purpose Crew Vehicle (MPCV). The Orion MPCV is part of the architecture within the Space Launch System (SLS), which is being designed to transport astronauts beyond low-Earth orbit for future exploration missions. Had the Orion PA-1 flight abort occurred during launch preparations for a real human spaceflight mission, the PA-1 LAS would have saved the lives of the crew. The PA-1 flight test was largely successful due to the three solid rocket motors of the LAS: the Attitude Control Motor (ACM); the Jettison Motor (JM); and the Abort Motor (AM). All three rocket motors successfully performed their required functions during the Orion PA-1 flight test, flown on May 6, 2010 at the White Sands Missile Range in New Mexico, culminating in a successful demonstration of an abort capability from the launchpad.

  16. Case of spontaneous ventriculocisternostomy

    Yamane, Kanji; Yoshimoto, Hisanori; Harada, Kiyoshi; Uozumi, Tohru (Hiroshima Univ. (Japan). School of Medicine); Kuwabara, Satoshi

    1983-05-01

    The authors experienced a case of spontaneous ventriculocisternostomy diagnosed by CT scan with metrizamide and Conray. Patient was 23-year-old male who had been in good health until one month before admission, when he began to have headache and tinnitus. He noticed bilateral visual acuity was decreased about one week before admission and vomiting appeared two days before admission. He was admitted to our hospital because of bilateral papilledema and remarkable hydrocephalus diagnosed by CT scan. On admission, no abnormal neurological signs except for bilateral papilledema were noted. Immediately, right ventricular drainage was performed. Pressure of the ventricle was over 300mmH/sub 2/O and CSF was clear. PVG and PEG disclosed an another cavity behind the third ventricle, which was communicated with the third ventricle, and occlusion of aqueduct of Sylvius. Metrizamide CT scan and Conray CT scan showed a communication between this cavity and quadrigeminal and supracerebellar cisterns. On these neuroradiological findings, the diagnosis of obstructive hydrocephalus due to benign aqueduct stenosis accompanied with spontaneous ventriculocisternostomy was obtained. Spontaneous ventriculocisternostomy was noticed to produce arrest of hydrocephalus, but with our case, spontaneous regression of such symptoms did not appeared. By surgical ventriculocisternostomy (method by Torkildsen, Dandy, or Scarff), arrest of hydrocephalus was seen in about 50 to 70 per cent, which was the same results as those of spontaneous ventriculocisternostomy. It is concluded that VP shunt or VA shunt is thought to be better treatment of obstructive hydrocephalus than the various kinds of surgical ventriculocisternostomy.

  17. Mifepristone With Buccal Misoprostol for Medical Abortion

    2015-01-01

    © 2015 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved. Objective: To summarize clinical outcomes and adverse effects of medical abortion regimens consisting of mifepristone followed by buccal misoprostol in pregnancies through 70 days of gestation. Data Sources: We used PubMed, ClinicalTrials.gov, and reference lists from published reports to identify relevant studies published between November 2005 and January 2015 usi...

  18. Spontaneous Perforation of Pyometra

    Begüm Yildizhan

    2006-01-01

    Full Text Available Pyometra is the accumulation of purulent material in the uterine cavity. Its reported incidence is 0.01–0.5% in gynecologic patients; however, as far as elderly patients are concerned, its incidence is 13.6% [3]. The most common cause of pyometra is malignant diseases of genital tract and the consequences of their treatment (radiotherapy. Other causes are benign tumors like leiomyoma, endometrial polyps, senile cervicitis, cervical occlusion after surgery, puerperal infections, and congenital cervical anomalies. Spontaneous rupture of the uterus is an extremely rare complication of pyometra. To our knowledge, only 21 cases of spontaneous perforation of pyometra have been reported in English literature since 1980. This paper reports an additional case of spontaneous uterine rupture.

  19. Constraints on Spontaneous Entrainment

    Richardson Michael J.

    2011-12-01

    Full Text Available Past research has revealed that a person's rhythmic limb movements become spontaneously entrained to an environmental rhythm if a. visual information about the environmental rhythm is available and b. its frequency of the environmental rhythm is near that of the person's movements. Further, this research has demonstrated that if the eyes track the environmental stimulus, the spontaneous entrainment to the environmental rhythm is strengthened. Experiments were performed to investigate two hypotheses that could explain this eye-tracking enhancement of spontaneous entrainment. One hypothesis is that eye tracking allows for the pick up of important coordinative information at the turn-around points of a movement trajectory. Another hypothesis is that the limb movements entrain to the moving eyes through a neuromotor synergy linking the eyes and limb. Results of these experiments will help delineate the informational and dynamical constraints that can impact the acquisition of skilled actions.

  20. [Primary spontaneous pneumomediastinum].

    Togashi, K; Hosaka, Y

    2007-12-01

    We report 5 cases of spontaneous pneumomediastinum. They were 4 men and 1 female with a mean age of 17 (14-25). Four patients developed sport-related pneumomediastinum and 1 patient had a karaoke-related condition. Primary spontaneous pneumomediasinum is a rare condition. In addition, there is no previous report describing karaoke-related spontaneous pneumomediastinum. Each of the patients experienced chest pain and/or neck pain before consulting our hospital. Chest roentgenogram and chest computed tomography showed pneumomediastinum without esophageal or tracheal injury. Four patients did not require hospitalization, but 1 patient was necessary to hospitalize for 7 days because of severe chest and neck pain. None of these 5 patients has had any recurrence for more than 1 year. Differentiating this entity from other diseases involving anterior chest pain is important.