Chicago aberration correction work
Beck, V.D., E-mail: vnlbeck@earthlink.net [1 Hobby Drive, Ridgefield, CT 06877-01922 (United States)
2012-12-15
The author describes from his personal involvement the many improvements to electron microscopy Albert Crewe and his group brought by minimizing the effects of aberrations. The Butler gun was developed to minimize aperture aberrations in a field emission electron gun. In the 1960s, Crewe anticipated using a spherical aberration corrector based on Scherzer's design. Since the tolerances could not be met mechanically, a method of moving the center of the octopoles electrically was developed by adding lower order multipole fields. Because the corrector was located about 15 cm ahead of the objective lens, combination aberrations would arise with the objective lens. This fifth order aberration would then limit the aperture of the microscope. The transformation of the off axis aberration coefficients of a round lens was developed and a means to cancel anisotropic coma was developed. A new method of generating negative spherical aberration was invented using the combination aberrations of hexapoles. Extensions of this technique to higher order aberrations were developed. An electrostatic electron mirror was invented, which allows the cancellation of primary spherical aberration and first order chromatic aberration. A reduction of chromatic aberration by two orders of magnitude was demonstrated using such a system. -- Highlights: Black-Right-Pointing-Pointer Crewe and his group made significant advances in aberration correction and reduction. Black-Right-Pointing-Pointer A deeper understanding of the quadrupole octopole corrector was developed. Black-Right-Pointing-Pointer A scheme to correct spherical aberration using hexapoles was developed. Black-Right-Pointing-Pointer Chromatic aberration was corrected using a uniform field mirror.
Aberration Corrected Emittance Exchange
Nanni, Emilio A
2015-01-01
Full exploitation of emittance exchange (EEX) requires aberration-free performance of a complex imaging system including active radio-frequency (RF) elements which can add temporal distortions. We investigate the performance of an EEX line where the exchange occurs between two dimensions with normalized emittances which differ by orders of magnitude. The transverse emittance is exchanged into the longitudinal dimension using a double dog-leg emittance exchange setup with a 5 cell RF deflector cavity. Aberration correction is performed on the four most dominant aberrations. These include temporal aberrations that are corrected with higher order magnetic optical elements located where longitudinal and transverse emittance are coupled. We demonstrate aberration-free performance of emittances differing by 4 orders of magnitude, i.e. an initial transverse emittance of $\\epsilon_x=1$ pm-rad is exchanged with a longitudinal emittance of $\\epsilon_z=10$ nm-rad.
Chicago aberration correction work.
Beck, V D
2012-12-01
The author describes from his personal involvement the many improvements to electron microscopy Albert Crewe and his group brought by minimizing the effects of aberrations. The Butler gun was developed to minimize aperture aberrations in a field emission electron gun. In the 1960s, Crewe anticipated using a spherical aberration corrector based on Scherzer's design. Since the tolerances could not be met mechanically, a method of moving the center of the octopoles electrically was developed by adding lower order multipole fields. Because the corrector was located about 15 cm ahead of the objective lens, combination aberrations would arise with the objective lens. This fifth order aberration would then limit the aperture of the microscope. The transformation of the off axis aberration coefficients of a round lens was developed and a means to cancel anisotropic coma was developed. A new method of generating negative spherical aberration was invented using the combination aberrations of hexapoles. Extensions of this technique to higher order aberrations were developed. An electrostatic electron mirror was invented, which allows the cancellation of primary spherical aberration and first order chromatic aberration. A reduction of chromatic aberration by two orders of magnitude was demonstrated using such a system.
Aberration Correction in Electron Microscopy
Rose, Harald H
2005-01-01
The resolution of conventional electron microscopes is limited by spherical and chromatic aberrations. Both defects are unavoidable in the case of static rotationally symmetric electromagnetic fields (Scherzer theorem). Multipole correctors and electron mirrros have been designed and built, which compensate for these aberrations. The principles of correction will be demonstrated for the tetrode mirror, the quadrupole-octopole corrector and the hexapole corrector. Electron mirrors require a magnetic beam separator free of second-order aberrations. The multipole correctors are highly symmetric telescopic systems compensating for the defects of the objective lens. The hexapole corrector has the most simple structure yet eliminates only the spherical aberration, whereas the mirror and the quadrupole-octopole corrector are able to correct for both aberrations. Chromatic correction is achieved in the latter corrector by cossed electric and magnetic quadrupoles acting as first-order Wien filters. Micrographs obtaine...
Historical aspects of aberration correction.
Rose, Harald H
2009-06-01
A brief history of the development of direct aberration correction in electron microscopy is outlined starting from the famous Scherzer theorem established in 1936. Aberration correction is the long story of many seemingly fruitless efforts to improve the resolution of electron microscopes by compensating for the unavoidable resolution-limiting aberrations of round electron lenses over a period of 50 years. The successful breakthrough, in 1997, can be considered as a quantum step in electron microscopy because it provides genuine atomic resolution approaching the size of the radius of the hydrogen atom. The additional realization of monochromators, aberration-free imaging energy filters and spectrometers has been leading to a new generation of analytical electron microscopes providing elemental and electronic information about the object on an atomic scale.
Aberration correction past and present.
Hawkes, P W
2009-09-28
Electron lenses are extremely poor: if glass lenses were as bad, we should see as well with the naked eye as with a microscope! The demonstration by Otto Scherzer in 1936 that skillful lens design could never eliminate the spherical and chromatic aberrations of rotationally symmetric electron lenses was therefore most unwelcome and the other great electron optician of those years, Walter Glaser, never ceased striving to find a loophole in Scherzer's proof. In the wartime and early post-war years, the first proposals for correcting C(s) were made and in 1947, in a second milestone paper, Scherzer listed these and other ways of correcting lenses; soon after, Dennis Gabor invented holography for the same purpose. These approaches will be briefly summarized and the work that led to the successful implementation of quadupole-octopole and sextupole correctors in the 1990 s will be analysed. In conclusion, the elegant role of image algebra in describing image formation and processing and, above all, in developing new methods will be mentioned.
Pulse compressor with aberration correction
Mankos, Marian [Electron Optica, Inc., Palo Alto, CA (United States)
2015-11-30
In this SBIR project, Electron Optica, Inc. (EOI) is developing an electron mirror-based pulse compressor attachment to new and retrofitted dynamic transmission electron microscopes (DTEMs) and ultrafast electron diffraction (UED) cameras for improving the temporal resolution of these instruments from the characteristic range of a few picoseconds to a few nanoseconds and beyond, into the sub-100 femtosecond range. The improvement will enable electron microscopes and diffraction cameras to better resolve the dynamics of reactions in the areas of solid state physics, chemistry, and biology. EOI’s pulse compressor technology utilizes the combination of electron mirror optics and a magnetic beam separator to compress the electron pulse. The design exploits the symmetry inherent in reversing the electron trajectory in the mirror in order to compress the temporally broadened beam. This system also simultaneously corrects the chromatic and spherical aberration of the objective lens for improved spatial resolution. This correction will be found valuable as the source size is reduced with laser-triggered point source emitters. With such emitters, it might be possible to significantly reduce the illuminated area and carry out ultrafast diffraction experiments from small regions of the sample, e.g. from individual grains or nanoparticles. During phase I, EOI drafted a set of candidate pulse compressor architectures and evaluated the trade-offs between temporal resolution and electron bunch size to achieve the optimum design for two particular applications with market potential: increasing the temporal and spatial resolution of UEDs, and increasing the temporal and spatial resolution of DTEMs. Specialized software packages that have been developed by MEBS, Ltd. were used to calculate the electron optical properties of the key pulse compressor components: namely, the magnetic prism, the electron mirror, and the electron lenses. In the final step, these results were folded
Catadioptric aberration correction in cathode lens microscopy
Tromp, R.M. [IBM T.J. Watson Research Center, PO Box 218, Yorktown Heights, NY 10598 (United States); Kamerlingh Onnes Laboratory, Leiden Institute of Physics, Niels Bohrweg 2, 2333 CA Leiden (Netherlands)
2015-04-15
In this paper I briefly review the use of electrostatic electron mirrors to correct the aberrations of the cathode lens objective lens in low energy electron microscope (LEEM) and photo electron emission microscope (PEEM) instruments. These catadioptric systems, combining electrostatic lens elements with a reflecting mirror, offer a compact solution, allowing simultaneous and independent correction of both spherical and chromatic aberrations. A comparison with catadioptric systems in light optics informs our understanding of the working principles behind aberration correction with electron mirrors, and may point the way to further improvements in the latter. With additional developments in detector technology, 1 nm spatial resolution in LEEM appears to be within reach. - Highlights: • The use of electron mirrors for aberration correction in LEEM/PEEM is reviewed. • A comparison is made with similar systems in light optics. • Conditions for 1 nm spatial resolution are discussed.
Optical advantages of astigmatic aberration corrected heliostats
van Rooyen, De Wet; Schöttl, Peter; Bern, Gregor; Heimsath, Anna; Nitz, Peter
2016-05-01
Astigmatic aberration corrected heliostats adapt their shape in dependence of the incidence angle of the sun on the heliostat. Simulations show that this optical correction leads to a higher concentration ratio at the target and thus in a decrease in required receiver aperture in particular for smaller heliostat fields.
Correcting the Chromatic Aberration in Barrel Distortion of Endoscopic Images
Y. M. Harry Ng
2003-04-01
Full Text Available Modern endoscopes offer physicians a wide-angle field of view (FOV for minimally invasive therapies. However, the high level of barrel distortion may prevent accurate perception of image. Fortunately, this kind of distortion may be corrected by digital image processing. In this paper we investigate the chromatic aberrations in the barrel distortion of endoscopic images. In the past, chromatic aberration in endoscopes is corrected by achromatic lenses or active lens control. In contrast, we take a computational approach by modifying the concept of image warping and the existing barrel distortion correction algorithm to tackle the chromatic aberration problem. In addition, an error function for the determination of the level of centroid coincidence is proposed. Simulation and experimental results confirm the effectiveness of our method.
The correction of electron lens aberrations
Hawkes, P.W., E-mail: peter.hawkes@cemes.fr
2015-09-15
The progress of electron lens aberration correction from about 1990 onwards is chronicled. Reasonably complete lists of publications on this and related topics are appended. A present for Max Haider and Ondrej Krivanek in the year of their 65th birthdays. By a happy coincidence, this review was completed in the year that both Max Haider and Ondrej Krivanek reached the age of 65. It is a pleasure to dedicate it to the two leading actors in the saga of aberration corrector design and construction. They would both wish to associate their colleagues with such a tribute but it is the names of Haider and Krivanek (not forgetting Joachim Zach) that will remain in the annals of electron optics, next to that of Harald Rose. I am proud to know that both regard me as a friend as well as a colleague. - Highlights: • Geometrical aberration correction. • Chromatic aberration correction. • 50 pm resolution. • High-resolution electron energy-loss spectroscopy. • Extensive bibliographies.
The investigation of chromatic aberration correction for digital eye fundus images
Jakstys, V.; Marcinkevicius, V.; Treigys, P.
2016-01-01
This paper focuses on the lateral chromatic aberration correction in images captured with Optomed SmartScope M5 camera. This portable non-mydriatic eye fundus orbital camera does not have chromatic lenses. When photo camera system is designed without chromatic lenses, it is necessary to apply image processing algorithms for lateral chromatic aberration effect correction. These algorithms try to scale the fringed colour channels so that all channels spatially overlap each other ...
Liu, Yan; Li, Yanqiu
2016-09-01
At present, few projection objectives for extreme ultraviolet (EUV) lithography pay attention to correct thermal aberration in optical design phase, which would lead to poor image quality in a practical working environment. We present an aspherical modification method for helping the EUV lithographic objective additionally correct the thermal aberration. Based on the thermal aberration and deformation predicted by integrated optomechanical analysis, the aspherical surfaces in an objective are modified by an iterative algorithm. The modified aspherical surfaces could correct the thermal aberration and maintain the initial high image quality in a practical working environment. A six-mirror EUV lithographic objective with 0.33-numerical aperture is taken as an example to illustrate the presented method. The results show that the thermal aberration can be corrected effectively, and the image quality of the thermally deformed system is improved to the initial design level, which proves the availability of the method.
Correcting Aberrations in Complex Magnet Systems for Muon Cooling Channels
J.A. Maloney, B. Erdelyi, A. Afanaciev, R.P. Johnson, Y.S. Derbenev, V.S. Morozov
2011-03-01
Designing and simulating complex magnet systems needed for cooling channels in both neutrino factories and muon colliders requires innovative techniques to correct for both chromatic and spherical aberrations. Optimizing complex systems, such as helical magnets for example, is also difficult but essential. By using COSY INFINITY, a differential algebra based code, the transfer and aberration maps can be examined to discover what critical terms have the greatest influence on these aberrations.
Design of an aberration corrected low-voltage SEM
Aken, R.H. van; Maas, D.J.; Hagen, C.W.; Barth, J.E.; Kruit, P.
2010-01-01
The low-voltage foil corrector is a novel type of foil aberration corrector that can correct for both the spherical and chromatic aberration simultaneously. In order to give a realistic example of the capabilities of this corrector, a design for a low-voltage scanning electron microscope with the lo
Numerical correction of aberrations via phase retrieval with speckle illumination
Almoro, Percival; Gundu, Phanindra Narayan; Hanson, Steen Grüner
2009-01-01
What we believe to be a novel technique for wavefront aberration measurement using speckle patterns is presented. The aberration correction is done numerically. A tilted lens is illuminated with a partially developed speckle field, and the transmitted light intensity is sampled at axially displaced...
Automated spherical aberration correction in scanning confocal microscopy
Yoo, H.W.; Royen, M.E.; van Cappellen, W.A.; Houtsmuller, A.B.; Verhaegen, M.H.G.; Schitter, G.
2014-01-01
Mismatch between the refractive indexes of immersion media and glass coverslips introduces spherical aberrations in microscopes especially for high numerical aperture objectives. This contribution demonstrates an automated adjustment of the coverslip correction collar in scanning confocal microscopy
Adaptive aberration correction using a triode hyperbolic electron mirror.
Fitzgerald, J P S; Word, R C; Könenkamp, R
2011-01-01
A converging electron mirror can be used to compensate spherical and chromatic aberrations in an electron microscope. This paper presents an analytical solution to a novel triode (three electrode) hyperbolic mirror as an improvement to the well-known diode (two electrode) hyperbolic mirror for aberration correction. A weakness of the diode mirror is a lack of flexibility in changing the chromatic and spherical aberration coefficients independently without changes in the mirror geometry. In order to remove this limitation, a third electrode can be added. We calculate the optical properties of the resulting triode mirror analytically on the basis of a simple model field distribution. We present the optical properties-the object/image distance, z(0), and the coefficients of spherical and chromatic aberration, C(s) and C(c), of both mirror types from an analysis of electron trajectories in the mirror field. From this analysis, we demonstrate that while the properties of both designs are similar, the additional parameters in the triode mirror improve the range of aberration that can be corrected. The triode mirror is also able to provide a dynamic adjustment range of chromatic aberration for fixed spherical aberration and focal length, or any permutation of these three parameters. While the dynamic range depends on the values of aberration correction needed, a nominal 10% tuning range is possible for most configurations accompanied by less than 1% change in the other two properties.
Prospects for electron beam aberration correction using sculpted phase masks
Shiloh, Roy, E-mail: royshilo@post.tau.ac.il; Remez, Roei; Arie, Ady
2016-04-15
Technological advances in fabrication methods allowed the microscopy community to take incremental steps towards perfecting the electron microscope, and magnetic lens design in particular. Still, state of the art aberration-corrected microscopes are yet 20–30 times shy of the theoretical electron diffraction limit. Moreover, these microscopes consume significant physical space and are very expensive. Here, we show how a thin, sculpted membrane is used as a phase-mask to induce specific aberrations into an electron beam probe in a standard high resolution TEM. In particular, we experimentally demonstrate beam splitting, two-fold astigmatism, three-fold astigmatism, and spherical aberration. - Highlights: • Thin membranes can be used as aberration correctors in electron columns. • We demonstrate tilt, twofold-, threefold-astigmatism, and spherical aberrations. • Experimental and physical-optics simulation results are in good agreement. • Advantages in cost, size, nonmagnetism, and nearly-arbitrary correction.
Pande, Paritosh; Liu, Yuan-Zhi; South, Fredrick A; Boppart, Stephen A
2016-07-15
Numerical correction of optical aberrations provides an inexpensive and simpler alternative to the traditionally used hardware-based adaptive optics techniques. In this Letter, we present an automated computational aberration correction method for broadband interferometric imaging techniques. In the proposed method, the process of aberration correction is modeled as a filtering operation on the aberrant image using a phase filter in the Fourier domain. The phase filter is expressed as a linear combination of Zernike polynomials with unknown coefficients, which are estimated through an iterative optimization scheme based on maximizing an image sharpness metric. The method is validated on both simulated data and experimental data obtained from a tissue phantom, an ex vivo tissue sample, and an in vivo photoreceptor layer of the human retina.
Double aberration correction in a low-energy electron microscope
Schmidt, Th., E-mail: schmidtt@fhi-berlin.mpg.de [Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 6-8, D-14195 Berlin (Germany); Universitaet Wuerzburg, Experimentelle Physik II, Am Hubland, D-97074 Wuerzburg (Germany); Marchetto, H.; Levesque, P.L. [Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 6-8, D-14195 Berlin (Germany); Groh, U.; Maier, F. [Universitaet Wuerzburg, Experimentelle Physik II, Am Hubland, D-97074 Wuerzburg (Germany); Preikszas, D. [Technische Universitaet Darmstadt, Angewandte Physik, Hochschulstrasse 6, D-64289 Darmstadt (Germany); Carl Zeiss NTS GmbH, Carl-Zeiss-Strasse 56, D-73447 Oberkochen (Germany); Hartel, P.; Spehr, R. [Technische Universitaet Darmstadt, Angewandte Physik, Hochschulstrasse 6, D-64289 Darmstadt (Germany); Lilienkamp, G. [Technische Universitaet Clausthal, Physikalisches Institut, Leibnizstrasse 4, D-38678 (Germany); Engel, W. [Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 6-8, D-14195 Berlin (Germany); Fink, R. [Universitaet Erlangen-Nuernberg, Physikalische Chemie II, Egerlandstrasse 3, D-91058 Erlangen (Germany); Bauer, E. [Technische Universitaet Clausthal, Physikalisches Institut, Leibnizstrasse 4, D-38678 (Germany); Arizona State University, Department of Physics, Tempe, AZ 85287 (United States); Rose, H. [Technische Universitaet Darmstadt, Angewandte Physik, Hochschulstrasse 6, D-64289 Darmstadt (Germany); Umbach, E. [Universitaet Wuerzburg, Experimentelle Physik II, Am Hubland, D-97074 Wuerzburg (Germany); Freund, H.-J. [Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 6-8, D-14195 Berlin (Germany)
2010-10-15
The lateral resolution of a surface sensitive low-energy electron microscope (LEEM) has been improved below 4 nm for the first time. This breakthrough has only been possible by simultaneously correcting the unavoidable spherical and chromatic aberrations of the lens system. We present an experimental criterion to quantify the aberration correction and to optimize the electron optical system. The obtained lateral resolution of 2.6 nm in LEEM enables the first surface sensitive, electron microscopic observation of the herringbone reconstruction on the Au(1 1 1) surface.
Correction of low order aberrations using continuous deformable mirrors.
Vdovin, Gleb; Soloviev, Oleg; Samokhin, Alexander; Loktev, Mikhail
2008-03-03
By analyzing the Poisson equation describing the static behavior of membrane and bimorph deformable mirrors and biharmonic equation describing the continuous facesheet mirror with push-pull actuators, we found that to achieve a high quality correction of low-order aberrations these mirrors should have sufficient number of actuators positioned outside the correction aperture. In particular, any deformable mirror described by the Poisson equation requires at least two actuators to be placed outside the working aperture per period of the azimuthal aberration of the highest expected order. Any deformable mirror described by the biharmonic equation, such as a continuous facesheet mirror with push-pull actuators, requires at least four actuators to be placed outside the working aperture per period of the azimuthal aberration of the highest expected order, and these actuators should not be positioned on a single circle.
An electron microscope for the aberration-corrected era.
Krivanek, O L; Corbin, G J; Dellby, N; Elston, B F; Keyse, R J; Murfitt, M F; Own, C S; Szilagyi, Z S; Woodruff, J W
2008-02-01
Improved resolution made possible by aberration correction has greatly increased the demands on the performance of all parts of high-end electron microscopes. In order to meet these demands, we have designed and built an entirely new scanning transmission electron microscope (STEM). The microscope includes a flexible illumination system that allows the properties of its probe to be changed on-the-fly, a third-generation aberration corrector which corrects all geometric aberrations up to fifth order, an ultra-responsive yet stable five-axis sample stage, and a flexible configuration of optimized detectors. The microscope features many innovations, such as a modular column assembled from building blocks that can be stacked in almost any order, in situ storage and cleaning facilities for up to five samples, computer-controlled loading of samples into the column, and self-diagnosing electronics. The microscope construction is described, and examples of its capabilities are shown.
OPTIMIZED STRAPDOWN CONING CORRECTION ALGORITHM
黄磊; 刘建业; 曾庆化
2013-01-01
Traditional coning algorithms are based on the first-order coning correction reference model .Usually they reduce the algorithm error of coning axis (z) by increasing the sample numbers in one iteration interval .But the increase of sample numbers requires the faster output rates of sensors .Therefore ,the algorithms are often lim-ited in practical use .Moreover ,the noncommutivity error of rotation usually exists on all three axes and the in-crease of sample numbers has little positive effect on reducing the algorithm errors of orthogonal axes (x ,y) . Considering the errors of orthogonal axes cannot be neglected in the high-precision applications ,a coning algorithm with an additional second-order coning correction term is developed to further improve the performance of coning algorithm .Compared with the traditional algorithms ,the new second-order coning algorithm can effectively reduce the algorithm error without increasing the sample numbers .Theoretical analyses validate that in a coning environ-ment with low frequency ,the new algorithm has the better performance than the traditional time-series and fre-quency-series coning algorithms ,while in a maneuver environment the new algorithm has the same order accuracy as the traditional time-series and frequency-series algorithms .Finally ,the practical feasibility of the new coning al-gorithm is demonstrated by digital simulations and practical turntable tests .
Prospects for electron beam aberration correction using sculpted phase masks.
Shiloh, Roy; Remez, Roei; Arie, Ady
2016-04-01
Technological advances in fabrication methods allowed the microscopy community to take incremental steps towards perfecting the electron microscope, and magnetic lens design in particular. Still, state of the art aberration-corrected microscopes are yet 20-30 times shy of the theoretical electron diffraction limit. Moreover, these microscopes consume significant physical space and are very expensive. Here, we show how a thin, sculpted membrane is used as a phase-mask to induce specific aberrations into an electron beam probe in a standard high resolution TEM. In particular, we experimentally demonstrate beam splitting, two-fold astigmatism, three-fold astigmatism, and spherical aberration. Copyright © 2016 Elsevier B.V. All rights reserved.
Differential aberration correction (DAC) microscopy: a new molecular ruler.
Vallotton, P
2008-11-01
Considerable efforts have been deployed towards measuring molecular range distances in fluorescence microscopy. In the 1-10 nm range, Förster energy transfer microscopy is difficult to beat. Above 300 nm, conventional diffraction limited microscopy is suitable. We introduce a simple experimental technique that allows bridging the gap between those two resolution scales in both 2D and 3D with a resolution of about 20 nm. The method relies on a computational approach to accurately correct optical aberrations over the whole field of view. The method is differential because the probes of interest are affected in exactly the same manner by aberrations as are the reference probes used to construct the aberration deformation field. We expect that this technique will have significant implications for investigating structural and functional questions in bio-molecular sciences.
Aberration correction for time-domain ultrasound diffraction tomography.
Mast, T Douglas
2002-07-01
Extensions of a time-domain diffraction tomography method, which reconstructs spatially dependent sound speed variations from far-field time-domain acoustic scattering measurements, are presented and analyzed. The resulting reconstructions are quantitative images with applications including ultrasonic mammography, and can also be considered candidate solutions to the time-domain inverse scattering problem. Here, the linearized time-domain inverse scattering problem is shown to have no general solution for finite signal bandwidth. However, an approximate solution to the linearized problem is constructed using a simple delay-and-sum method analogous to "gold standard" ultrasonic beamforming. The form of this solution suggests that the full nonlinear inverse scattering problem can be approximated by applying appropriate angle- and space-dependent time shifts to the time-domain scattering data; this analogy leads to a general approach to aberration correction. Two related methods for aberration correction are presented: one in which delays are computed from estimates of the medium using an efficient straight-ray approximation, and one in which delays are applied directly to a time-dependent linearized reconstruction. Numerical results indicate that these correction methods achieve substantial quality improvements for imaging of large scatterers. The parametric range of applicability for the time-domain diffraction tomography method is increased by about a factor of 2 by aberration correction.
Effect of chromatic aberration on atomic-resolved spherical aberration corrected STEM images.
Kuramochi, Koji; Yamazaki, Takashi; Kotaka, Yasutoshi; Ohtsuka, Masahiro; Hashimoto, Iwao; Watanabe, Kazuto
2009-12-01
The effect of the chromatic aberration (C(c)) coefficient in a spherical aberration (C(s))- corrected electromagnetic lens on high-resolution high-angle annular dark field (HAADF) scanning transmission electron microscope (STEM) images is explored in detail. A new method for precise determination of the C(c) coefficient is demonstrated, requiring measurement of an atomic-resolution one-frame through-focal HAADF STEM image. This method is robust with respect to instrumental drift, sample thickness, all lens parameters except C(c), and experimental noise. It is also demonstrated that semi-quantitative structural analysis on the nanometer scale can be achieved by comparing experimental C(s)- corrected HAADF STEM images with their corresponding simulated images when the effects of the C(c) coefficient and spatial incoherence are included.
Harmonic source wavefront aberration correction for ultrasound imaging
Dianis, Scott W.; von Ramm, Olaf T.
2011-01-01
A method is proposed which uses a lower-frequency transmit to create a known harmonic acoustical source in tissue suitable for wavefront correction without a priori assumptions of the target or requiring a transponder. The measurement and imaging steps of this method were implemented on the Duke phased array system with a two-dimensional (2-D) array. The method was tested with multiple electronic aberrators [0.39π to 1.16π radians root-mean-square (rms) at 4.17 MHz] and with a physical aberrator 0.17π radians rms at 4.17 MHz) in a variety of imaging situations. Corrections were quantified in terms of peak beam amplitude compared to the unaberrated case, with restoration between 0.6 and 36.6 dB of peak amplitude with a single correction. Standard phantom images before and after correction were obtained and showed both visible improvement and 14 dB contrast improvement after correction. This method, when combined with previous phase correction methods, may be an important step that leads to improved clinical images. PMID:21303031
Eliminating chromatic aberration in Gauss-type lens design using a novel genetic algorithm.
Fang, Yi-Chin; Tsai, Chen-Mu; Macdonald, John; Pai, Yang-Chieh
2007-05-01
Two different types of Gauss lens design, which effectively eliminate primary chromatic aberration, are presented using an efficient genetic algorithm (GA). The current GA has to deal with too many targets in optical global optimization so that the performance is not much improved. Generally speaking, achromatic aberrations have a great relationship with variable glass sets for all elements. For optics whose design is roughly convergent, glass sets for optics will play a significant role in axial and lateral color aberration. Therefore better results might be derived from the optimal process of eliminating achromatic aberration, which could be carried out by finding feasible glass sets in advance. As an alternative, we propose a new optimization process by using a GA and involving theories of geometrical optics in order to select the best optical glass combination. Two Gauss-type lens designs are employed in this research. First, a telephoto lens design is sensitive to axial aberration because of its long focal length, and second, a wide-angle Gauss design is complicated by lateral color aberration at the extreme corners because Gauss design is well known not to deal well with wide-angle problems. Without numbers of higher chief rays passing the element, it is difficult to correct lateral color aberration altogether for the Gauss design. The results and conclusions show that the attempts to eliminate primary chromatic aberrations were successful.
Adaptive dispersion formula for index interpolation and chromatic aberration correction.
Li, Chia-Ling; Sasián, José
2014-01-13
This paper defines and discusses a glass dispersion formula that is adaptive. The formula exhibits superior convergence with a minimum number of coefficients. Using this formula we rationalize the correction of chromatic aberration per spectrum order. We compare the formula with the Sellmeier and Buchdahl formulas for glasses in the Schott catalogue. The six coefficient adaptive formula is found to be the most accurate with an average maximum index of refraction error of 2.91 × 10(-6) within the visible band.
Influence of Misalignment on High-Order Aberration Correction for Normal Human Eyes
ZHAO Hao-Xin; XU Bing; XUE Li-Xia; DAI Yun; LIU Qian; RAO Xue-Jun
2008-01-01
@@ Although a compensation device can correct aberrations of human eyes, the effect will be degraded by its misalignment, especially for high-order aberration correction. We caJculate the positioning tolerance of correction device for high-order aberrations, and within what degree the correcting effect is better than low-order aberration (defocus and astigmatism) correction. With fixed certain misalignment within the positioning tolerance, we calculate the residual wavefront rms aberration of the first-6 to first-35 terms along with the 3rd-5th terms of aberrations corrected, and the combined first-13 terms of aberrations are also studied under the same quantity of misalignment. However, the correction effect of high-order aberrations does not meliorate along with the increase of the high-order terms under some misalignment, moreover, some simple combined terms correction can achieve similar result as complex combinations. These results suggest that it is unnecessary to correct too much the terms of high-order aberrations which are diffcult to accomplish in practice, and gives confdence to correct high-order aberrations out of the laboratory.
Florian; T; A; Kretz; Tamer; Tandogan; Ramin; Khoramnia; Gerd; U; Auffarth
2015-01-01
·AIM: To evaluate the quality of vision in respect to high order aberrations and straylight perception after implantation of an aspheric, aberration correcting,monofocal intraocular lens(IOL).·METHODS: Twenty-one patients(34 eyes) aged 50 to83 y underwent cataract surgery with implantation of an aspheric, aberration correcting IOL(Tecnis ZCB00,Abbott Medical Optics). Three months after surgery they were examined for uncorrected(UDVA) and corrected distance visual acuity(CDVA), contrast sensitivity(CS)under photopic and mesopic conditions with and without glare source, ocular high order aberrations(HOA, Zywave II) and retinal straylight(C-Quant).· RESULTS: Postoperatively, patients achieved a postoperative CDVA of 0.0 log MAR or better in 97.1% of eyes. Mean values of high order abberations were +0.02±0.27(primary coma components) and-0.04 ±0.16(spherical aberration term). Straylight values of the C-Quant were 1.35±0.44 log which is within normal range of age matched phakic patients. The CS measurements under mesopic and photopic conditions in combination with and without glare did not show any statistical significance in the patient group observed(P ≥0.28).· CONCLUSION: The implantation of an aspherical aberration correcting monofocal IOL after cataractsurgery resulted in very low residual higher order aberration(HOA) and normal straylight.
A simulation study comparing aberration detection algorithms for syndromic surveillance
Painter Ian
2007-03-01
Full Text Available Abstract Background The usefulness of syndromic surveillance for early outbreak detection depends in part on effective statistical aberration detection. However, few published studies have compared different detection algorithms on identical data. In the largest simulation study conducted to date, we compared the performance of six aberration detection algorithms on simulated outbreaks superimposed on authentic syndromic surveillance data. Methods We compared three control-chart-based statistics, two exponential weighted moving averages, and a generalized linear model. We simulated 310 unique outbreak signals, and added these to actual daily counts of four syndromes monitored by Public Health – Seattle and King County's syndromic surveillance system. We compared the sensitivity of the six algorithms at detecting these simulated outbreaks at a fixed alert rate of 0.01. Results Stratified by baseline or by outbreak distribution, duration, or size, the generalized linear model was more sensitive than the other algorithms and detected 54% (95% CI = 52%–56% of the simulated epidemics when run at an alert rate of 0.01. However, all of the algorithms had poor sensitivity, particularly for outbreaks that did not begin with a surge of cases. Conclusion When tested on county-level data aggregated across age groups, these algorithms often did not perform well in detecting signals other than large, rapid increases in case counts relative to baseline levels.
Image transfer with spatial coherence for aberration corrected transmission electron microscopes.
Hosokawa, Fumio; Sawada, Hidetaka; Shinkawa, Takao; Sannomiya, Takumi
2016-08-01
The formula of spatial coherence involving an aberration up to six-fold astigmatism is derived for aberration-corrected transmission electron microscopy. Transfer functions for linear imaging are calculated using the newly derived formula with several residual aberrations. Depending on the symmetry and origin of an aberration, the calculated transfer function shows characteristic symmetries. The aberrations that originate from the field's components, having uniformity along the z direction, namely, the n-fold astigmatism, show rotational symmetric damping of the coherence. The aberrations that originate from the field's derivatives with respect to z, such as coma, star, and three lobe, show non-rotational symmetric damping. It is confirmed that the odd-symmetric wave aberrations have influences on the attenuation of an image via spatial coherence. Examples of image simulations of haemoglobin and Si [211] are shown by using the spatial coherence for an aberration-corrected electron microscope.
A method of dynamic chromatic aberration correction in low-voltage scanning electron microscopes.
Khursheed, Anjam
2005-07-01
A time-of-flight concept that dynamically corrects for chromatic aberration effects in scanning electron microscopes (SEMs) is presented. The method is predicted to reduce the microscope's chromatic aberration by an order of magnitude. The scheme should significantly improve the spatial resolution of low-voltage scanning electron microscopes (LVSEMs). The dynamic means of correcting for chromatic aberration also allows for the possibility of obtaining high image resolution from electron guns that have relatively large energy spreads.
Sensor-less aberration correction in optical imaging systems using blind optimization
Avanaki, Mohammad R. N.; Mazraeh Khoshki, R.; Hojjatoleslami, S. A.; Podoleanu, A. Gh.
2012-02-01
The imperfection of optical devices in an optical imaging system deteriorates wavefront which results in aberration. This reduces the optical signal to noise ratio of the imaging system and the quality of the produced images. Adaptive optics composed of wavefront sensor (WFS) and deformable mirror (DM) is a straightforward solution for this problem. The need for a WFS in an AO system, raises the cost of the overall system, and there are also instances when they cannot be used, such as in microscopy. Moreover stray reflections from lens surfaces affect the performance of the WFS. In this paper, we describe a blind optimization technique with an in-expensive electronics without using the WFS to correct the aberration in order to achieve better quality images. The correction system includes an electromagnetic DM from Imagine, Mirao52d, with 52 actuators which are controlled by particle swarm optimization (PSO) algorithm. The results of the application of simulated annealing (SA), and genetic algorithm (GA) techniques that we have implemented in the sensor-less AO are used for comparison.
High-resolution TEM and the application of direct and indirect aberration correction
Hetherington, Crispin J.D.; Chang, Lan-Yun Shery; Haigh, Sarah
2008-01-01
Aberration correction leads to a substantial improvement in the directly interpretable resolution of transmission electron microscopes. Correction of the aberrations has been achieved electron-optically through a hexapole-based corrector and also indirectly by computational analysis of a focal or...
Sabesan, Ramkumar; Jeong, Tae Moon; Carvalho, Luis; Cox, Ian G.; Williams, David R.; Yoon, Geunyoung
2007-04-01
Higher-order aberration correction in abnormal eyes can result in significant vision improvement, especially in eyes with abnormal corneas. Customized optics such as phase plates and customized contact lenses are one of the most practical, nonsurgical ways to correct these ocular higher-order aberrations. We demonstrate the feasibility of correcting higher-order aberrations and improving visual performance with customized soft contact lenses in keratoconic eyes while compensating for the static decentration and rotation of the lens. A reduction of higher-order aberrations by a factor of 3 on average was obtained in these eyes. The higher-order aberration correction resulted in an average improvement of 2.1 lines in visual acuity over the conventional correction of defocus and astigmatism alone.
Albert, O; Sherman, L; Mourou, G; Norris, T B; Vdovin, G
2000-01-01
Off-axis aberrations in a beam-scanning multiphoton confocal microscope are corrected with a deformable mirror. The optimal mirror shape for each pixel is determined by a genetic learning algorithm, in which the second-harmonic or two-photon fluorescence signal from a reference sample is maximized. The speed of the convergence is improved by use of a Zernike polynomial basis for the deformable mirror shape. This adaptive optical correction scheme is implemented in an all-reflective system by use of extremely short (10-fs) optical pulses, and it is shown that the scanning area of an f:1 off-axis parabola can be increased by nine times with this technique.
Information transfer in a TEM corrected for spherical and chromatic aberration.
Haider, M; Hartel, P; Müller, H; Uhlemann, S; Zach, J
2010-08-01
For the transmission electron aberration-corrected microscope (TEAM) initiative of five U.S. Department of Energy laboratories in the United States, a correction system for the simultaneous compensation of the primary axial aberrations, the spherical aberration Cs, and the chromatic aberration Cc has been developed and successfully installed. The performance of the resulting Cc /Cs-corrected TEAM instrument has been investigated thoroughly. A significant improvement of the linear contrast transfer can be demonstrated. The information about the instrument one obtains using Young's fringe method is compared for uncorrected, Cs-corrected, and Cc /Cs-corrected instruments. The experimental results agree well with simulations. The conclusions might be useful to others in understanding the process of image formation in a Cc /Cs-corrected transmission electron microscope.
Brief history of the Cambridge STEM aberration correction project and its progeny
Brown, L. Michael [Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Batson, Philip E. [Institute for Advanced Materials, Devices and Nanotechnology, Rutgers University, Piscataway, NJ 08854 (United States); Department of Physics, Rutgers University, Piscataway, NJ 08854 (United States); Department of Materials Science, Rutgers University, Piscataway, NJ 08854 (United States); Dellby, Niklas [Nion Company, 11515 NE 118th Street, Kirkland, WA 98034 (United States); Krivanek, Ondrej L. [Nion Company, 11515 NE 118th Street, Kirkland, WA 98034 (United States); Department of Physics, Arizona State University, Tempe, AZ 85287 (United States)
2015-10-15
We provide a brief history of the project to correct the spherical aberration of the scanning transmission electron microscope (STEM) that started in Cambridge (UK) and continued in Kirkland (WA, USA), Yorktown Heights (NY, USA), and other places. We describe the project in the full context of other aberration correction research and related work, partly in response to the incomplete context presented in the paper “In quest of perfection in electron optics: A biographical sketch of Harald Rose on the occasion of his 80th birthday”, recently published in Ultramicroscopy. - Highlights: • We provide a brief history of the Cambridge project to correct the spherical aberration of the scanning transmission electron microscope (STEM). • We describe the project in the full context of other aberration correction work and related research. • We summarize our corrector development work that followed the Cambridge project, and which was the first to reach higher spatial resolution than any non-corrected electron microscope.
Yang, Bin; Wei, Yin; Chen, Xinhua; Tang, Minxue
2014-11-01
Membrane mirror with flexible polymer film substrate is a new-concept ultra lightweight mirror for space applications. Compared with traditional mirrors, membrane mirror has the advantages of lightweight, folding and deployable, low cost and etc. Due to the surface shape of flexible membrane mirror is easy to deviate from the design surface shape, it will bring wavefront aberration to the optical system. In order to solve this problem, a method of membrane mirror wavefront aberration correction based on the liquid crystal spatial light modulator (LCSLM) will be studied in this paper. The wavefront aberration correction principle of LCSLM is described and the phase modulation property of a LCSLM is measured and analyzed firstly. Then the membrane mirror wavefront aberration correction system is designed and established according to the optical properties of a membrane mirror. The LCSLM and a Hartmann-Shack sensor are used as a wavefront corrector and a wavefront detector, respectively. The detected wavefront aberration is calculated and converted into voltage value on LCSLM for the mirror wavefront aberration correction by programming in Matlab. When in experiment, the wavefront aberration of a glass plane mirror with a diameter of 70 mm is measured and corrected for verifying the feasibility of the experiment system and the correctness of the program. The PV value and RMS value of distorted wavefront are reduced and near diffraction limited optical performance is achieved. On this basis, the wavefront aberration of the aperture center Φ25 mm in a membrane mirror with a diameter of 200 mm is corrected and the errors are analyzed. It provides a means of correcting the wavefront aberration of membrane mirror.
Study on the modification of measured wavefront aberration data for customized visual correction
Liu, Ming; Zhang, Yong; Zhang, Zhidong; Quan, Wei; An, Li
2008-12-01
Wavefront aberration of human eye is an important foundation for customized vision correction. In most current aberrometers, near infrared light is used to measure ocular wavefront aberration, whereas for customized visual correction, wavefront aberration data in visible range are required. With the measured wavefront aberration, corneal topography and eye's axial lengths data, individual eye models for twenty normal human eyes are constructed with the optical design software ZEMAX. Changing the incidence light wavelength and the refractive indexes of eye models, the values of defocus, astigmatism, higher-order aberrations in the measuring wavelength (833nm) and at the most sensitive wavelength of human eye (555nm) are obtained. Average focus shift between 833nm and 555nm is found to be about 0.94D, and different slightly for different individuals; the differences of astigmatism and higher-order aberrations between 833nm and 555nm are quite slight. For customized visual correction, the measured defocus value should be modified, whereas the measured astigmatism and higher-order aberrations could be used directly for the current correction precision. Individual eye model is a useful tool for accurate transformation of the measured wavefront aberration data into the data for visible spectrum.
Focus correction in an apodized system with spherical aberration.
Bernal-Molina, Paula; Castejón-Mochón, José Francisco; Bradley, Arthur; López-Gil, Norberto
2015-08-01
We performed a theoretical and computational analysis of the through-focus axial irradiance in a system with a Gaussian amplitude pupil function and fourth- and sixth-order spherical aberration (SA). Two cases are analyzed: low aberrated systems, and the human eye containing significant levels of SA and a natural apodization produced by the Stiles-Crawford effect. Results show that apodization only produces a refraction change of the plane that maximized the Strehl ratio for eyes containing significant levels of negative SA.
Xue, Lixia; Dai, Yun; Rao, Xuejun; Wang, Cheng; Hu, Yiyun; Liu, Qian; Jiang, Wenhan
2008-01-01
Higher-order aberrations correction can improve visual performance of human eye to some extent. To evaluate how much visual benefit can be obtained with higher-order aberrations correction we developed an adaptive optics vision simulator (AOVS). Dynamic real time optimized modal compensation was used to implement various customized higher-order ocular aberrations correction strategies. The experimental results indicate that higher-order aberrations correction can improve visual performance of human eye comparing with only lower-order aberration correction but the improvement degree and higher-order aberration correction strategy are different from each individual. Some subjects can acquire great visual benefit when higher-order aberrations were corrected but some subjects acquire little visual benefit even though all higher-order aberrations were corrected. Therefore, relative to general lower-order aberrations correction strategy, customized higher-order aberrations correction strategy is needed to obtain optimal visual improvement for each individual. AOVS provides an effective tool for higher-order ocular aberrations optometry for customized ocular aberrations correction.
Kulyas, Oleg L.; Nikitin, Konstantin A.
2016-03-01
Ways of chromatic aberration in images are examined and analyzed which are generated at television supervision through protective glasses of a considerable thickness. The results of experimental check up of the given method of correction is introduced and described.
Yavor, M.I. [Institute for Analytical Instrumentation RAS, 190103 St. Petersburg (Russian Federation)], E-mail: mikhail.yavor@gmail.com; Belov, V.D.; Pomozov, T.V. [Institute for Analytical Instrumentation RAS, 190103 St. Petersburg (Russian Federation)
2008-12-15
A new way of correcting the second-order angular aberration in sector field and polar-toroidal electron energy analyzers with object and image located outside the field is proposed. Correction is performed by biasing the optic axis electrostatic potential inside the analyzer with respect to the potential of surrounding field-free space. The strength of the correcting aberration concentrated in the fringing field regions of the analyzer is calculated with the aid of the fringing field integral method. The described correction allows achieving second-order focusing and thus increasing the energy resolving power in sector field analyzers, in particular used for angle resolved energy measurements.
Correction of Optical Aberrations in Elliptic Neutron Guides
Bentley, Phillip M; Andersen, Ken H; Rodriguez, Damian Martin; Mildner, David F R
2012-01-01
Modern, nonlinear ballistic neutron guides are an attractive concept in neutron beam delivery and instrumentation, because they offer increased performance over straight or linearly tapered guides. However, like other ballistic geometries they have the potential to create significantly non-trivial instrumental resolution functions. We address the source of the most prominent optical aberration, namely coma, and we show that for extended sources the off-axis rays have a different focal length from on-axis rays, leading to multiple reflections in the guide system. We illustrate how the interplay between coma, sources of finite size, and mirrors with non-perfect reflectivity can therefore conspire to produce uneven distributions in the neutron beam divergence, the source of complicated resolution functions. To solve these problems, we propose a hybrid elliptic-parabolic guide geometry. Using this new kind of neutron guide shape, it is possible to condition the neutron beam and remove almost all of the aberration...
Design of macro-filter-lens with simultaneous chromatic and geometric aberration correction.
Prasad, Dilip K; Brown, Michael S
2014-01-01
A macro-filter-lens design that can correct for chromatic and geometric aberrations simultaneously while providing for a long focal length is presented. The filter is easy to fabricate since it involves two spherical surfaces and a planar surface. Chromatic aberration correction is achieved by making all the rays travel the same optical distance inside the filter element (negative meniscus). Geometric aberration is corrected for by the lens element (plano-convex), which makes the output rays parallel to the optic axis. This macro-filter-lens design does not need additional macro lenses and it provides an inexpensive and optically good (aberration compensated) solution for macro imaging of objects not placed close to the camera.
Aberration-corrected STEM/TEM imaging at 15 kV
Sasaki, Takeo, E-mail: tasasaki@jeol.co.jp [EM Business Unit, JEOL Ltd., 3-1-2 Musashino, Akishima, Tokyo 196-8558 (Japan); Sawada, Hidetaka; Hosokawa, Fumio [EM Business Unit, JEOL Ltd., 3-1-2 Musashino, Akishima, Tokyo 196-8558 (Japan); Sato, Yuta; Suenaga, Kazu [Nanotube Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, Higashi 1-1-1, Tsukuba, Ibaraki 305-8565 (Japan)
2014-10-15
The performance of aberration-corrected (scanning) transmission electron microscopy (S/TEM) at an accelerating voltage of 15 kV was evaluated in a low-voltage microscope equipped with a cold-field emission gun and a higher-order aberration corrector. Aberrations up to the fifth order were corrected by the aberration measurement and auto-correction system using the diffractogram tableau method in TEM and Ronchigram analysis in STEM. TEM observation of nanometer-sized particles demonstrated that aberrations up to an angle of 50 mrad were compensated. A TEM image of Si[110] exhibited lattice fringes with a spacing of 0.192 nm, and the power spectrum of the image showed spots corresponding to distances of 0.111 nm. An annular dark-field STEM image of Si[110] showed lattice fringes of (111) and (22¯0) planes corresponding to lattice distances of 0.314 nm and 0.192 nm, respectively. At an accelerating voltage of 15 kV, the developed low-voltage microscope achieved atomic-resolution imaging with a small chromatic aberration and a large uniform phase. - Highlights: • Aberration-corrected STEM/TEM imaging at 15 kV demonstrated lattice fringes of Si[110] single crystal with a spacing of 0.192 nm. • To achieve this performance at a lower accelerating voltage, uniform phase area over 50 mrad is mandatory in Ronchigram and Diffractogram tableau. • This means a higher-order aberration of six-fold astigmatism should be compensated. • In addition, decreasing the effect of chromatic aberration plays an important role for improving the performance of linear scattering component at 15 kV TEM.
Jones, L; Nellist, P D
2014-05-01
In the scanning transmission electron microscope, hardware aberration correctors can now correct for the positive spherical aberration of round electron lenses. These correctors make use of nonround optics such as hexapoles or octupoles, leading to the limiting aberrations often being of a nonround type. Here we explore the effect of a number of potential limiting aberrations on the imaging performance of the scanning transmission electron microscope through their resulting optical transfer functions. In particular, the response of the optical transfer function to changes in defocus are examined, given that this is the final aberration to be tuned just before image acquisition. The resulting three-dimensional optical transfer functions also allow an assessment of the performance of a system for focal-series experiments or optical sectioning applications. © 2014 The Authors Journal of Microscopy © 2014 Royal Microscopical Society.
Huang, Chao; Nie, Liming; Schoonover, Robert W.; Guo, Zijian; Schirra, Carsten O.; Anastasio, Mark A.; Wang, Lihong V.
2012-06-01
A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.
Kvyetnyy, Roman; Sofina, Olga; Orlyk, Pavel; Utreras, Andres J.; Smolarz, Andrzej; Wójcik, Waldemar; Orazalieva, Sandugash
2016-09-01
A new approach to solve the problem of image correction to improve the quality perception of graphic information by people with aberrations of the eye optical system is considered in given article. The model of higher order aberrations which may appear in the human eye optical system is described. The developed approach is based on the pre-processing of digital images and applying of the filtration methods to the adjusted images.
Correction of axial and lateral chromatic aberration with false color filtering.
Chang, Joonyoung; Kang, Hee; Kang, Moon Gi
2013-03-01
In this paper, we propose a chromatic aberration (CA) correction algorithm based on a false color filtering technique. In general, CA produces color distortions called color fringes near the contrasting edges of captured images, and these distortions cause false color artifacts. In the proposed method, a false color filtering technique is used to filter out the false color components from the chroma-signals of the input image. The filtering process is performed with the adaptive weights obtained from both the gradient and color differences, and the weights are designed to reduce the various types of color fringes regardless of the colors of the artifacts. Moreover, as preprocessors of the filtering process, a transient improvement (TI) technique is applied to enhance the slow transitions of the red and blue channels that are blurred by the CA. The TI process improves the filtering performance by narrowing the false color regions before the filtering process when severe color fringes (typically purple fringes) occur widely. Last, the CA-corrected chroma-signal is combined with the TI chroma-signal to avoid incorrect color adjustment. The experimental results show that the proposed method substantially reduces the CA artifacts and provides natural-looking replacement colors, while it avoids incorrect color adjustment.
Aberration-corrected STEM/TEM imaging at 15kV.
Sasaki, Takeo; Sawada, Hidetaka; Hosokawa, Fumio; Sato, Yuta; Suenaga, Kazu
2014-10-01
The performance of aberration-corrected (scanning) transmission electron microscopy (S/TEM) at an accelerating voltage of 15kV was evaluated in a low-voltage microscope equipped with a cold-field emission gun and a higher-order aberration corrector. Aberrations up to the fifth order were corrected by the aberration measurement and auto-correction system using the diffractogram tableau method in TEM and Ronchigram analysis in STEM. TEM observation of nanometer-sized particles demonstrated that aberrations up to an angle of 50mrad were compensated. A TEM image of Si[110] exhibited lattice fringes with a spacing of 0.192nm, and the power spectrum of the image showed spots corresponding to distances of 0.111nm. An annular dark-field STEM image of Si[110] showed lattice fringes of (111) and (22¯0) planes corresponding to lattice distances of 0.314nm and 0.192nm, respectively. At an accelerating voltage of 15kV, the developed low-voltage microscope achieved atomic-resolution imaging with a small chromatic aberration and a large uniform phase.
Adaptive correction of human-eye aberrations in a subjective feedback loop.
Vdovin, G; Loktev, M; Simonov, A; Kijko, V; Volkov, S
2005-04-01
An adaptive optical system with a subjective feedback loop is used to improve the visual acuity and to determine the aberrations of the human eye. Corrections of as many as 12 low-order aberration modes were made, based on the perceived sharpness of the test object observed through the adaptive optical system. The acuity of vision was improved by adjustment of the weights of the orthogonal modes produced by a deformable mirror. Objective measurements of the correcting aspherical figures, obtained in independent subjective correction cycles for one person, demonstrated good repeatability. Participants in the study with strong ocular aberrations reported moderate to significant improvement of their visual acuity, estimated with the U.S. Air Force 1951 acuity chart.
Chen, D; Jones, S M; Silva, D A; Olivier, S S
2007-01-25
Scanning laser ophthalmoscopes with adaptive optics (AOSLO) have been shown previously to provide a noninvasive, cellular-scale view of the living human retina. However, the clinical utility of these systems has been limited by the available deformable mirror technology. In this paper, we demonstrate that the use of dual deformable mirrors can effectively compensate large aberrations in the human retina, making the AOSLO system a viable, non-invasive, high-resolution imaging tool for clinical diagnostics. We used a bimorph deformable mirror to correct low-order aberrations with relatively large amplitudes. The bimorph mirror is manufactured by Aoptix, Inc. with 37 elements and 18 {micro}m stroke in a 10 mm aperture. We used a MEMS deformable mirror to correct high-order aberrations with lower amplitudes. The MEMS mirror is manufactured by Boston Micromachine, Inc with 144 elements and 1.5 {micro}m stroke in a 3 mm aperture. We have achieved near diffraction-limited retina images using the dual deformable mirrors to correct large aberrations up to {+-} 3D of defocus and {+-} 3D of cylindrical aberrations with test subjects. This increases the range of spectacle corrections by the AO systems by a factor of 10, which is crucial for use in the clinical environment. This ability for large phase compensation can eliminate accurate refractive error fitting for the patients, which greatly improves the system ease of use and efficiency in the clinical environment.
Tanabe, Ayano; Hibi, Terumasa; Ipponjima, Sari; Matsumoto, Kenji; Yokoyama, Masafumi; Kurihara, Makoto; Hashimoto, Nobuyuki; Nemoto, Tomomi
2016-03-01
Laser scanning microscopy allows 3D cross-sectional imaging inside biospecimens. However, certain aberrations produced can degrade the quality of the resulting images. We previously reported a transmissive liquid-crystal device that could compensate for the predominant spherical aberrations during the observations, particularly in deep regions of the samples. The device, inserted between the objective lens and the microscope revolver, improved the image quality of fixed-mouse-brain slices that were observed using two-photon excitation laser scanning microscopy, which was originally degraded by spherical aberration. In this study, we developed a transmissive device that corrects primary coma aberration and astigmatism, motivated by the fact that these asymmetric aberrations can also often considerably deteriorate image quality, even near the sample surface. The device's performance was evaluated by observing fluorescent beads using single-photon excitation laser scanning microscopy. The fluorescence intensity in the image of the bead under a cover slip tilted in the y-direction was increased by 1.5 times after correction by the device. Furthermore, the y- and z-widths of the imaged bead were reduced to 66% and 65%, respectively. On the other hand, for the imaged bead sucked into a glass capillary in the longitudinal x-direction, correction with the device increased the fluorescence intensity by 2.2 times compared to that of the aberrated image. In addition, the x-, y-, and z-widths of the bead image were reduced to 75%, 53%, and 40%, respectively. Our device successfully corrected several asymmetric aberrations to improve the fluorescent signal and spatial resolution, and might be useful for observing various biospecimens.
Brief history of the Cambridge STEM aberration correction project and its progeny.
Brown, L Michael; Batson, Philip E; Dellby, Niklas; Krivanek, Ondrej L
2015-10-01
We provide a brief history of the project to correct the spherical aberration of the scanning transmission electron microscope (STEM) that started in Cambridge (UK) and continued in Kirkland (WA, USA), Yorktown Heights (NY, USA), and other places. We describe the project in the full context of other aberration correction research and related work, partly in response to the incomplete context presented in the paper "In quest of perfection in electron optics: A biographical sketch of Harald Rose on the occasion of his 80th birthday", recently published in Ultramicroscopy.
Active site of bimetallic heterogeneous catalyst by atomic resolution aberration-corrected STEM
Hsiao, Chien-Nan, E-mail: 0209347@narlabs.org.tw; Lin, Chun-Ting
2015-11-01
Highlights: • Up to fifth order aberration coefficients of STEM had been compensated. • The core-shell structural catalyst was identified by Z-contrast image. • Atomic twinning in nanoparticle was revealed by aberration-corrected STEM. - Abstract: The localized defect of Au–Pd bimetallic heterogeneous nanoparticles catalyst was investigated using HRTEM and aberration-corrected HRSTEM. The phase plates were calculated from the aberration coefficients of the measured probe tableau for various outer tilt angle of the optical axis and the accuracy required for the compensation of the various residual aberration coefficients in order to achieve sub-angstrom resolution with the electron optics system was evaluated up to the fifth order aberrations. It is found that the interplanar spacing of the Au–Pd nanoparticle (1 1 1) planes observed along the [1 1 0] zone axis was approximately 0.24 nm measured by HRTEM. In addition, the HRSTEM HAADF image demonstrated that the twin boundaries on the surfaces of heterogeneous nanoparticles catalysts at atomic scale. These defects might be introduced during the growth to alleviate the internal stress caused by the 4.6% lattice mismatch of Au–Pd bimetallic system. Current research could be applied to the study of active sites in nanocatalysts.
Conformal optical design with combination of static and dynamic aberration corrections
Li Yan; Li Lin; Huang Yi-Fan; Liu Jia-Guo
2009-01-01
Conformal domes that are shaped to meet aerodynamic requirements can increase range and speed for the host platform. Because these domes typically deviate greatly from spherical surface descriptions, a variety of aberrations are induced which vary with the field-of-regard (FOR) angle. A system for correcting optical aberrations created by a conformal dome has an outer surface and an inner surface. Optimizing the inner surface is regard as static aberration correction. A deformable mirror is placed at the position of the secondary mirror in the two-mirror all reflective imaging system, which is the dynamic aberration correction. An ellipsoidal MgF2 conformal dome with a fineness ratio of 1.0 is designed as an example. The FOR angle is 00°-30°, and the design wavelength is 4 μm. After the optimization at 7zoom positions by using the design tools Code V, the root-mean-square (RMS) spot size is reduced to approximately 0.99 to 1.48 times the diffraction limit. The design results show that the performances of the conformal optical systems can be greatly improved by the combination of the static correction and the dynamic correction.
Chromatic aberration correction of the human eye for retinal imaging in the near infrared.
Fernández, Enrique J; Unterhuber, Angelika; Povazay, Boris; Hermann, Boris; Artal, Pablo; Drexler, Woflgang
2006-06-26
An achromatizing lens has been designed for the human eye in the near infrared range, from 700 to 900 nm, for retinal imaging purposes. Analysis of the performance of the lens, including tolerance to misalignments, has been mathematically accomplished by using an existing eye model. The calculations have shown a virtually perfect correction of the ocular longitudinal chromatic aberration, while still keeping a high optical quality. Ocular aberrations in five subjects have been measured with and without the achromatizing lens by using a Hartmann-Shack wavefront sensor and a broad bandwidth femtosecond Ti:sapphire laser in the spectral range of interest with a set of interference filters, studying the benefits and limits in the use of the achromatizing lens. Ocular longitudinal chromatic aberration has been experimentally demonstrated to be fully corrected by the proposed lens, with no induction of any other parasitic aberration. The practical implementation of the achromatizing lens for Ophthalmoscopy, specifically for optical coherence tomography where the use of polychromatic light sources in the near infrared portion of the spectrum is mandatory, has been considered. The potential benefits of using this lens in combination with adaptive optics to achieve a full aberration correction of the human eye for retinal imaging have also been discussed.
Ionosphere correction algorithm for spaceborne SAR imaging
Lin Yang; Mengdao Xing; Guangcai Sun
2016-01-01
For spaceborne synthetic aperture radar (SAR) ima-ging, the dispersive ionosphere has significant effects on the pro-pagation of the low frequency (especial y P-band) radar signal. The ionospheric effects can be a significant source of the phase error in the radar signal, which causes a degeneration of the image quality in spaceborne SAR imaging system. The background ionospheric effects on spaceborne SAR through modeling and simulation are analyzed, and the qualitative and quantitative analysis based on the spatio-temporal variability of the ionosphere is given. A novel ionosphere correction algorithm (ICA) is proposed to deal with the ionospheric effects on the low frequency spaceborne SAR radar signal. With the proposed algorithm, the degradation of the image quality caused by the ionosphere is corrected. The simulation re-sults show the effectiveness of the proposed algorithm.
Exploring the depth range for three-dimensional laser machining with aberration correction.
Salter, P S; Baum, M; Alexeev, I; Schmidt, M; Booth, M J
2014-07-28
The spherical aberration generated when focusing from air into another medium limits the depth at which ultrafast laser machining can be accurately maintained. We investigate how the depth range may be extended using aberration correction via a liquid crystal spatial light modulator (SLM), in both single point and parallel multi-point fabrication in fused silica. At a moderate numerical aperture (NA = 0.5), high fidelity fabrication with a significant level of parallelisation is demonstrated at the working distance of the objective lens, corresponding to a depth in the glass of 2.4 mm. With a higher numerical aperture (NA = 0.75) objective lens, single point fabrication is demonstrated to a depth of 1 mm utilising the full NA, and deeper with reduced NA, while maintaining high repeatability. We present a complementary theoretical model that enables prediction of the effectiveness of SLM based correction for different aberration magnitudes.
Shaw, Michael; Hall, Simon; Knox, Steven; Stevens, Richard; Paterson, Carl
2010-03-29
In this paper we describe the wavefront aberrations that arise when imaging biological specimens using an optical sectioning microscope and generate simulated wavefronts for a planar refractive index mismatch. We then investigate the capability of two deformable mirrors for correcting spherical aberration at different focusing depths for three different microscope objective lenses. Along with measurement and analysis of the mirror influence functions we determine the optimum mirror pupil size and number of spatial modes included in the wavefront expansion and we present measurements of actuator linearity and hysteresis. We find that both mirrors are capable of correcting the wavefront aberration to improve imaging and greatly extend the depth at which diffraction limited imaging is possible.
Schramm, S.M., E-mail: schramm@physics.leidenuniv.nl [Leiden University, Kamerlingh Onnes Laboratorium, P.O. Box 9504, NL-2300 RA Leiden (Netherlands); Pang, A.B. [School of Physics and Electronic Information, Huaibei Normal University, Huaibei, Anhui 235000 (China); Department of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong (China); Altman, M.S. [Department of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong (China); Tromp, R.M. [Leiden University, Kamerlingh Onnes Laboratorium, P.O. Box 9504, NL-2300 RA Leiden (Netherlands); IBM T.J. Watson Research Center, 1101 Kitchawan Road, P.O. Box 218, Yorktown Heights, NY 10598 (United States)
2012-04-15
We introduce an extended Contrast Transfer Function (CTF) approach for the calculation of image formation in low energy electron microscopy (LEEM) and photo electron emission microscopy (PEEM). This approach considers aberrations up to fifth order, appropriate for image formation in state-of-the-art aberration-corrected LEEM and PEEM. We derive Scherzer defocus values for both weak and strong phase objects, as well as for pure amplitude objects, in non-aberration-corrected and aberration-corrected LEEM. Using the extended CTF formalism, we calculate contrast and resolution of one-dimensional and two-dimensional pure phase, pure amplitude, and mixed phase and amplitude objects. PEEM imaging is treated by adapting this approach to the case of incoherent imaging. Based on these calculations, we show that the ultimate resolution in aberration-corrected LEEM is about 0.5 nm, and in aberration-corrected PEEM about 3.5 nm. The aperture sizes required to achieve these ultimate resolutions are precisely determined with the CTF method. The formalism discussed here is also relevant to imaging with high resolution transmission electron microscopy. -- Highlights: Black-Right-Pointing-Pointer We introduce an extended Contrast Transfer Function (CTF) approach for the calculation of image formation in low energy electron microscopy (LEEM) and photo electron emission microscopy (PEEM). Black-Right-Pointing-Pointer We consider aberrations up to fifth order, appropriate for image formation in state-of-the-art aberration-corrected LEEM and PEEM. Black-Right-Pointing-Pointer We derive Scherzer defocus values for both weak and strong phase objects, as well as for pure amplitude objects, in non-aberration-corrected and aberration-corrected LEEM. Black-Right-Pointing-Pointer We show that the ultimate resolution in aberration-corrected LEEM is about 0.5 nm, and in aberration-corrected PEEM about 3.5 nm.
Non-common path aberration correction in an adaptive optics scanning ophthalmoscope.
Sulai, Yusufu N; Dubra, Alfredo
2014-09-01
The correction of non-common path aberrations (NCPAs) between the imaging and wavefront sensing channel in a confocal scanning adaptive optics ophthalmoscope is demonstrated. NCPA correction is achieved by maximizing an image sharpness metric while the confocal detection aperture is temporarily removed, effectively minimizing the monochromatic aberrations in the illumination path of the imaging channel. Comparison of NCPA estimated using zonal and modal orthogonal wavefront corrector bases provided wavefronts that differ by ~λ/20 in root-mean-squared (~λ/30 standard deviation). Sequential insertion of a cylindrical lens in the illumination and light collection paths of the imaging channel was used to compare image resolution after changing the wavefront correction to maximize image sharpness and intensity metrics. Finally, the NCPA correction was incorporated into the closed-loop adaptive optics control by biasing the wavefront sensor signals without reducing its bandwidth.
A new aberration-corrected, energy-filtered LEEM/PEEM instrument II. Operation and results
Tromp, R.M., E-mail: rtromp@us.ibm.com [IBM T.J. Watson Research Center, 1101 Kitchawan Road, P.O. Box 218, Yorktown Heights, NY 10598 (United States); Hannon, J.B. [IBM T.J. Watson Research Center, 1101 Kitchawan Road, P.O. Box 218, Yorktown Heights, NY 10598 (United States); Wan, W. [Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 80R0114, Berkeley, CA 94720 (United States); Berghaus, A.; Schaff, O. [SPECS GmbH, Voltastrasse 5, D-13355 Berlin (Germany)
2013-04-15
In Part I we described a new design for an aberration-corrected Low Energy Electron Microscope (LEEM) and Photo Electron Emission Microscope (PEEM) equipped with an in-line electron energy filter. The chromatic and spherical aberrations of the objective lens are corrected with an electrostatic electron mirror that provides independent control of the chromatic and spherical aberration coefficients C{sub c} and C{sub 3}, as well as the mirror focal length. In this Part II we discuss details of microscope operation, how the microscope is set up in a systematic fashion, and we present typical results. - Highlights: ► The C{sub c} and C{sub 3} aberrations of a LEEM/PEEM instrument are corrected with an electrostatic electron mirror. ► The mirror provides independent control over C{sub c}, C{sub 3} and focal length in close agreement with theory. ► A detailed alignment procedure for the corrected microscope is given. ► Novel methods to measure C{sub c} and C{sub 3} of the objective lens and the mirror are presented. ► We demonstrate a record spatial resolution of 2 nm.
Aberration-corrected imaging of active sites on industrial catalyst nanoparticles
Gontard, Lionel Cervera; Chang, L-Y; Hetherington, CJD
2007-01-01
Picture perfect: Information about the local topologies of active sites on commercial nanoparticles can be gained with atomic resolution through spherical-aberration-corrected transmission electron microscopy (TEM). A powder of Pt nanoparticles on carbon black was examined with two advanced TEM t...
Aberration-corrected imaging of active sites on industrial catalyst nanoparticles
Gontard, Lionel Cervera; Chang, L-Y; Hetherington, CJD;
2007-01-01
Picture perfect: Information about the local topologies of active sites on commercial nanoparticles can be gained with atomic resolution through spherical-aberration-corrected transmission electron microscopy (TEM). A powder of Pt nanoparticles on carbon black was examined with two advanced TEM t...
Chromatic Aberration Correction for Atomic Resolution TEM Imaging from 20 to 80 kV
Linck, Martin; Hartel, Peter; Uhlemann, Stephan; Kahl, Frank; Müller, Heiko; Zach, Joachim; Haider, Max.; Niestadt, Marcel; Bischoff, Maarten; Biskupek, Johannes; Lee, Zhongbo; Lehnert, Tibor; Börrnert, Felix; Rose, Harald; Kaiser, Ute
2016-08-01
Atomic resolution in transmission electron microscopy of thin and light-atom materials requires a rigorous reduction of the beam energy to reduce knockon damage. However, at the same time, the chromatic aberration deteriorates the resolution of the TEM image dramatically. Within the framework of the SALVE project, we introduce a newly developed Cc/Cs corrector that is capable of correcting both the chromatic and the spherical aberration in the range of accelerating voltages from 20 to 80 kV. The corrector allows correcting axial aberrations up to fifth order as well as the dominating off-axial aberrations. Over the entire voltage range, optimum phase-contrast imaging conditions for weak signals from light atoms can be adjusted for an optical aperture of at least 55 mrad. The information transfer within this aperture is no longer limited by chromatic aberrations. We demonstrate the performance of the microscope using the examples of 30 kV phase-contrast TEM images of graphene and molybdenum disulfide, showing unprecedented contrast and resolution that matches image calculations.
Chromatic Aberration Correction for Atomic Resolution TEM Imaging from 20 to 80 kV.
Linck, Martin; Hartel, Peter; Uhlemann, Stephan; Kahl, Frank; Müller, Heiko; Zach, Joachim; Haider, Max; Niestadt, Marcel; Bischoff, Maarten; Biskupek, Johannes; Lee, Zhongbo; Lehnert, Tibor; Börrnert, Felix; Rose, Harald; Kaiser, Ute
2016-08-12
Atomic resolution in transmission electron microscopy of thin and light-atom materials requires a rigorous reduction of the beam energy to reduce knockon damage. However, at the same time, the chromatic aberration deteriorates the resolution of the TEM image dramatically. Within the framework of the SALVE project, we introduce a newly developed C_{c}/C_{s} corrector that is capable of correcting both the chromatic and the spherical aberration in the range of accelerating voltages from 20 to 80 kV. The corrector allows correcting axial aberrations up to fifth order as well as the dominating off-axial aberrations. Over the entire voltage range, optimum phase-contrast imaging conditions for weak signals from light atoms can be adjusted for an optical aperture of at least 55 mrad. The information transfer within this aperture is no longer limited by chromatic aberrations. We demonstrate the performance of the microscope using the examples of 30 kV phase-contrast TEM images of graphene and molybdenum disulfide, showing unprecedented contrast and resolution that matches image calculations.
Automatic low-order aberration correction based on geometry optics: simulations
Yu, Xin; Dong, Lizhi; Liu, Yong; Yang, Ping; Tang, Guomao; Xu, Bing
2016-10-01
The slab laser is a promising architecture to achieve high beam quality and high power. By propagating the laser beams in zigzag geometries, the temperature gradient in the gain medium can be well averaged, and the beam quality in this direction can be excellent. However, the temperature gradient in the non-zigzag direction is not compensated, resulting in aberrations in this direction which lead to poorer beam quality. Among the overall aberrations, the main contributors are two low-order aberrations: astigmatism and defocus. These aberrations will magnify beam divergence angle and degrade beam quality. If the beam divergence angles in both directions are almost zero, the astigmatism and defocus are well corrected. Besides, the output beams of slab lasers are generally in a rectangular aperture with high aspect ratio (normally 1:10), which need to be reshaped into square in many applications. In this paper, a new method is proposed to correct low-order aberrations and reshape the beams of slab lasers. Three lenses are adapted, one is a spherical lens and the others are cylindrical lenses. These lenses work as a beam shaping system, which converts the beam from rectangular into square and the low-order aberrations are compensated simultaneously. Two wavefront sensors are used to detect input and output beam parameters. The initial size of the beam is 4mm×20mm, and peak to valley (PV) value of the wavefront is several tens of microns. Simulation results show that after correction, the dimension becomes 40mm×40mm, and peak to valley (PV) value of the wavefront is less than 1microns.
An Aberration Corrected Photoemission Electron Microscope at the Advanced Light Source
Feng, J.; MacDowell, A. A.; Duarte, R.; Doran, A.; Forest, E.; Kelez, N.; Marcus, M.; Munson, D.; Padmore, H.; Petermann, K.; Raoux, S.; Robin, D.; Scholl, A.; Schlueter, R.; Schmid, P.; Stöhr, J.; Wan, W.; Wei, D. H.; Wu, Y.
2004-05-01
Design of a new aberration corrected Photoemission electron microscope PEEM3 at the Advanced Light Source is outlined. PEEM3 will be installed on an elliptically polarized undulator beamline and will be used for the study of complex materials at high spatial and spectral resolution. The critical components of PEEM3 are the electron mirror aberration corrector and aberration-free magnetic beam separator. The models to calculate the optical properties of the electron mirror are discussed. The goal of the PEEM3 project is to achieve the highest possible transmission of the system at resolutions comparable to our present PEEM2 system (50 nm) and to enable significantly higher resolution, albeit at the sacrifice of intensity. We have left open the possibility to add an energy filter at a later date, if it becomes necessary driven by scientific need to improve the resolution further.
Rasgele, Pinar Goc; Kaymak, Fisun
2010-03-01
Natamycin [corrected] is used as preservative in foods. The genotoxic effects of the food preservative natamycin [corrected] were evaluated using chromosome aberrations and micronucleus test in bone marrow cells and sperm head abnormality assays in mice. Blood samples were taken from mice and levels of total testosterone in serum were also determined. Natamycin [corrected] was intraperitoneally (ip) injected at 200, 400 and 800 mg/kg. Natamycin [corrected] did not induce chromosome aberrations but significantly increased the number of micronucleated polychromatic erythrocytes in bone marrow and sperm head abnormalities at all concentrations and treatment periods. It also decreased MI at all concentrations for 6, 12 and 24h treatment periods. Natamycin [corrected] decreased PCE/NCE ratio at all concentrations for 48h in female mice, for 24 and 48h treatment periods in male mice. At the 800 mg/kg concentration, natamycin [corrected] decreased PCE/NCE ratio for 24 and 72h in female mice. A dose dependent increase was observed in the percentage of sperm head abnormalities. The levels of serum testosterone decreased dose-dependently. The obtained results indicate that natamycin [corrected] is not clastogenic, but it is aneugenic in mice bone marrow and it is a potential germ cell mutagen in sperm cells.
Fitzgerald, J P S; Word, R C; Könenkamp, R
2012-04-01
We present a theoretical analysis of an electrostatic triode mirror combined with an einzel lens for the correction of spherical and chromatic aberration. We show that this device adaptively corrects spherical and chromatic aberration simultaneously and independently. Chromatic aberration can be compensated over a relative range of -38% to +100%, and spherical aberration over ±100% range. We compare the analytic calculation with a numerical simulation and show that the two descriptions agree to within 5% in the relevant operating regime of the device.
Hossein-Babaei, Faraz; Koh, Ai Leen; Srinivasan, Kumar; Bertero, Gerardo A; Sinclair, Robert
2012-05-09
In perpendicular hard disk memory media, nanometric magnetic Co-rich grains are separated by a ∼1 nm thick nonmagnetic and preferably amorphous intergranular phase (IP). Attempts at observing the IP structure at high resolution using TEM have been obstructed by the superposition of lattice fringes from the crystalline grains extending into the IP region in images. Here we present the first images of a magnetic recording medium produced using a spherical aberration-corrected TEM showing the true amorphous IP structure in contrast to the crystalline grains, allowing the accurate determination of the grain-IP interface and the grain and IP dimensions. It is shown that these aberration-corrected TEM images are functionally superior for analyzing certain features of the ultrahigh capacity data recording media.
Algorithmic Error Correction of Impedance Measuring Sensors
Starostenko, Oleg; Alarcon-Aquino, Vicente; Hernandez, Wilmar; Sergiyenko, Oleg; Tyrsa, Vira
2009-01-01
This paper describes novel design concepts and some advanced techniques proposed for increasing the accuracy of low cost impedance measuring devices without reduction of operational speed. The proposed structural method for algorithmic error correction and iterating correction method provide linearization of transfer functions of the measuring sensor and signal conditioning converter, which contribute the principal additive and relative measurement errors. Some measuring systems have been implemented in order to estimate in practice the performance of the proposed methods. Particularly, a measuring system for analysis of C-V, G-V characteristics has been designed and constructed. It has been tested during technological process control of charge-coupled device CCD manufacturing. The obtained results are discussed in order to define a reasonable range of applied methods, their utility, and performance. PMID:22303177
Algorithmic Error Correction of Impedance Measuring Sensors
Vira Tyrsa
2009-12-01
Full Text Available This paper describes novel design concepts and some advanced techniques proposed for increasing the accuracy of low cost impedance measuring devices without reduction of operational speed. The proposed structural method for algorithmic error correction and iterating correction method provide linearization of transfer functions of the measuring sensor and signal conditioning converter, which contribute the principal additive and relative measurement errors. Some measuring systems have been implemented in order to estimate in practice the performance of the proposed methods. Particularly, a measuring system for analysis of C-V, G-V characteristics has been designed and constructed. It has been tested during technological process control of charge-coupled device CCD manufacturing. The obtained results are discussed in order to define a reasonable range of applied methods, their utility, and performance.
Optimization of neutron monitor data correction algorithms
Paschalis, P. [Nuclear and Particle Physics Section, Physics Department, National and Kapodistrian University of Athens, Zografos 15783, Athens (Greece); Mavromichalaki, H., E-mail: emavromi@phys.uoa.gr [Nuclear and Particle Physics Section, Physics Department, National and Kapodistrian University of Athens, Zografos 15783, Athens (Greece)
2013-06-21
Nowadays, several neutron monitor stations worldwide, broadcast their cosmic ray data in real time, in order for the scientific community to be able to use these measurements immediately. In parallel, the development of the Neutron Monitor Database (NMDB; (http://www.nmdb.eu)) which collects all the high resolution real time measurements, allows the implementation of various applications and services by using these data instantly. Therefore, it is obvious that the need for high quality real time data is imperative. The quality of the data is handled by different correction algorithms that filter the real time measurements for undesired instrumental variations. In this work, an optimization of the Median Editor that is currently mainly applied to the neutron monitor data and the recently proposed ANN algorithm based on neural networks is presented. This optimization leads to the implementation of the Median Editor Plus and the ANN Plus algorithms. A direct comparison of these algorithms with the newly appeared Edge Editor is performed and the results are presented.
Zhao, Chunzhu; Mao, Shan
2016-10-01
A static solution to aberrations and boresight error for tilted conformal aircraft windows at different look angles is reported, which is the use of tilted and decentered fixed correctors. The principle of the static solution is discussed, and three tilted and decentered fixed correctors are designed to correct the aberrations and boresight error for a conformal window. The correctors are fixed in position between the conformal window and the gimbaled imaging system, thus requiring no moving parts. The design result shows that the predominant astigmatism introduced by the conformal window is corrected by the tilted and decentered fixed correctors at different look angles. Moreover, the boresight error for the conformal window, as a function of look angle, is also corrected by the correctors. The root mean square wavefront aberration for the final conformal window imaging system is less than 0.2 wave across the full field of regard on the visible spectrum, and the boresight error is less than 0.5' across the full field of regard.
Aberration-Corrected Electron Beam Lithography at the One Nanometer Length Scale.
Manfrinato, Vitor R; Stein, Aaron; Zhang, Lihua; Nam, Chang-Yong; Yager, Kevin G; Stach, Eric A; Black, Charles T
2017-08-09
Patterning materials efficiently at the smallest length scales is a longstanding challenge in nanotechnology. Electron-beam lithography (EBL) is the primary method for patterning arbitrary features, but EBL has not reliably provided sub-4 nm patterns. The few competing techniques that have achieved this resolution are orders of magnitude slower than EBL. In this work, we employed an aberration-corrected scanning transmission electron microscope for lithography to achieve unprecedented resolution. Here we show aberration-corrected EBL at the one nanometer length scale using poly(methyl methacrylate) (PMMA) and have produced both the smallest isolated feature in any conventional resist (1.7 ± 0.5 nm) and the highest density patterns in PMMA (10.7 nm pitch for negative-tone and 17.5 nm pitch for positive-tone PMMA). We also demonstrate pattern transfer from the resist to semiconductor and metallic materials at the sub-5 nm scale. These results indicate that polymer-based nanofabrication can achieve feature sizes comparable to the Kuhn length of PMMA and ten times smaller than its radius of gyration. Use of aberration-corrected EBL will increase the resolution, speed, and complexity in nanomaterial fabrication.
Nickel, F., E-mail: fl.nickel@fz-juelich.de [Peter Grünberg Institut PGI-6 “Electronic Properties”, Research Center Jülich, 52425 Jülich (Germany); Gottlob, D.M. [Peter Grünberg Institut PGI-6 “Electronic Properties”, Research Center Jülich, 52425 Jülich (Germany); Fakultät für Physik und Center for Nanointegration Duisburg-Essen (CeNIDE), Universität Duisburg-Essen, 47048 Duisburg (Germany); Krug, I.P.; Doganay, H.; Cramm, S. [Peter Grünberg Institut PGI-6 “Electronic Properties”, Research Center Jülich, 52425 Jülich (Germany); Kaiser, A.M. [SPECS Surface Nano Analysis GmbH, Voltastraße 5, 13355 Berlin (Germany); Lin, G. [Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstraße 20, 01069 Dresden (Germany); Material Systems for Nanoelectronics, Chemnitz University of Technology, Reichenhainer Strasse 70, 09107 Chemnitz (Germany); Makarov, D.; Schmidt, O.G. [Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstraße 20, 01069 Dresden (Germany); and others
2013-07-15
We report on the implementation and usage of a synchrotron-based time-resolving operation mode in an aberration-corrected, energy-filtered photoemission electron microscope. The setup consists of a new type of sample holder, which enables fast magnetization reversal of the sample by sub-ns pulses of up to 10 mT. Within the sample holder current pulses are generated by a fast avalanche photo diode and transformed into magnetic fields by means of a microstrip line. For more efficient use of the synchrotron time structure, we developed an electrostatic deflection gating mechanism capable of beam blanking within a few nanoseconds. This allows us to operate the setup in the hybrid bunch mode of the storage ring facility, selecting one or several bright singular light pulses which are temporally well-separated from the normal high-intensity multibunch pulse pattern. - Highlights: • A new time-resolving operation mode in photoemission electron microscopy is shown. • Our setup works within an energy-filtered, aberration-corrected PEEM. • A new gating system for bunch selection using synchrotron radiation is developed. • An alternative magnetic excitation system is developed. • First tr-imaging using an energy-filtered, aberration-corrected PEEM is shown.
Imaging single atoms using secondary electrons with an aberration-corrected electron microscope.
Zhu, Y; Inada, H; Nakamura, K; Wall, J
2009-10-01
Aberration correction has embarked on a new frontier in electron microscopy by overcoming the limitations of conventional round lenses, providing sub-angstrom-sized probes. However, improvement of spatial resolution using aberration correction so far has been limited to the use of transmitted electrons both in scanning and stationary mode, with an improvement of 20-40% (refs 3-8). In contrast, advances in the spatial resolution of scanning electron microscopes (SEMs), which are by far the most widely used instrument for surface imaging at the micrometre-nanometre scale, have been stagnant, despite several recent efforts. Here, we report a new SEM, with aberration correction, able to image single atoms by detecting electrons emerging from its surface as a result of interaction with the small probe. The spatial resolution achieved represents a fourfold improvement over the best-reported resolution in any SEM (refs 10-12). Furthermore, we can simultaneously probe the sample through its entire thickness with transmitted electrons. This ability is significant because it permits the selective visualization of bulk atoms and surface ones, beyond a traditional two-dimensional projection in transmission electron microscopy. It has the potential to revolutionize the field of microscopy and imaging, thereby opening the door to a wide range of applications, especially when combined with simultaneous nanoprobe spectroscopy.
Dynamic Correction Algorithm of Rolling Force in Plate Rolling
QIU Hong-lei; WANG Jun; HU Xian-lei; WANG Zhao-dong; WANG Guo-dong
2005-01-01
Based on the Shougang plat mill project, an on-line dynamic correction algorithm was analyzed. This algorithm can adjust model coefficients better because the reasonable correction is based on the measured and calculated rolling force. The results of application on site show that this on-line dynamic correction algorithm is effective.
A proposal for the holographic correction of incoherent aberrations by tilted reference waves
Röder, Falk, E-mail: Falk.Roeder@Triebenberg.de; Lubk, Axel
2015-05-15
The recently derived general transfer theory for off-axis electron holography provides a new approach for reconstructing the electron wave beyond the conventional sideband information limit. Limited ensemble coherence of the electron beam between object and reference area leads to an attenuation of spatial frequencies of the object exit wave in the presence of aberrations of the objective lens. Concerted tilts of the reference wave under the condition of an invariant object exit wave are proposed to diminish the aberration impact on spatial frequencies even beyond the sideband information limit allowing its transfer with maximum possible contrast. In addition to the theoretical considerations outlined in detail, an experimental proof-of-principle is presented. A fully controlled tilt of the reference wave, however, remains as a promising task for the future. The use of a hologram series with varying reference wave tilt is considered for linearly synthesizing an effective aperture for the transfer into the sideband with broader bandwidth compared to conventional off-axis electron holography allowing us to correct the incoherent aberrations in transmission electron microscopy. Furthermore, tilting a reference wave with respect to a plane wave is expected to be an alternative way for measuring the coherent and incoherent aberrations of a transmission electron microscope. The capability of tilting the reference wave is expected to be beneficial for improving the signal-to-noise ratio in dark-field off-axis electron holography as well. - Highlights: • We examine the use of tilted reference waves in off-axis electron holography. • Generalized holographic transfer theory reveals a selective filtering effect. • We propose the correction of incoherent aberrations by series acquisitions. • For a proof-of-principle, we employ a crystal for tilting the reference wave.
Dynamic optical aberration correction with adaptive coded apertures techniques in conformal imaging
Li, Yan; Hu, Bin; Zhang, Pengbin; Zhang, Binglong
2015-02-01
Conformal imaging systems are confronted with dynamic aberration in optical design processing. In classical optical designs, for combination high requirements of field of view, optical speed, environmental adaption and imaging quality, further enhancements can be achieved only by the introduction of increased complexity of aberration corrector. In recent years of computational imaging, the adaptive coded apertures techniques which has several potential advantages over more traditional optical systems is particularly suitable for military infrared imaging systems. The merits of this new concept include low mass, volume and moments of inertia, potentially lower costs, graceful failure modes, steerable fields of regard with no macroscopic moving parts. Example application for conformal imaging system design where the elements of a set of binary coded aperture masks are applied are optimization designed is presented in this paper, simulation results show that the optical performance is closely related to the mask design and the reconstruction algorithm optimization. As a dynamic aberration corrector, a binary-amplitude mask located at the aperture stop is optimized to mitigate dynamic optical aberrations when the field of regard changes and allow sufficient information to be recorded by the detector for the recovery of a sharp image using digital image restoration in conformal optical system.
Lehtinen, Ossi, E-mail: ossi.lehtinen@gmail.com [Central Facility for Electron Microscopy, Group of Electron Microscopy of Materials Science, University of Ulm, 89081 Ulm (Germany); Geiger, Dorin; Lee, Zhongbo [Central Facility for Electron Microscopy, Group of Electron Microscopy of Materials Science, University of Ulm, 89081 Ulm (Germany); Whitwick, Michael Brian; Chen, Ming-Wei; Kis, Andras [Electrical Engineering Institute, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne (Switzerland); Kaiser, Ute [Central Facility for Electron Microscopy, Group of Electron Microscopy of Materials Science, University of Ulm, 89081 Ulm (Germany)
2015-04-15
Here, we present a numerical post-processing method for removing the effect of anti-symmetric residual aberrations in high-resolution transmission electron microscopy (HRTEM) images of weakly scattering 2D-objects. The method is based on applying the same aberrations with the opposite phase to the Fourier transform of the recorded image intensity and subsequently inverting the Fourier transform. We present the theoretical justification of the method, and its verification based on simulated images in the case of low-order anti-symmetric aberrations. Ultimately the method is applied to experimental hardware aberration-corrected HRTEM images of single-layer graphene and MoSe{sub 2} resulting in images with strongly reduced residual low-order aberrations, and consequently improved interpretability. Alternatively, this method can be used to estimate by trial and error the residual anti-symmetric aberrations in HRTEM images of weakly scattering objects.
Chung, Jaebum; Kim, Jinho; Ou, Xiaoze; Horstmeyer, Roarke; Yang, Changhuei
2016-03-01
We present a method to acquire both fluorescence and high-resolution bright-field images with correction for the spatially varying aberrations over a microscope's wide field-of-view (FOV). First, the procedure applies Fourier ptychographic microscopy (FPM) to retrieve the amplitude and phase of a sample, at a resolution that significantly exceeds the cutoff frequency of the microscope objective lens. At the same time, FPM algorithm is able to leverage on the redundancy within the set of acquired FPM bright-field images to estimate the microscope aberrations, which usually deteriorate in regions further away from the FOV's center. Second, the procedure acquires a raw wide-FOV fluorescence image within the same setup. Lack of moving parts allows us to use the FPM-estimated aberration map to computationally correct for the aberrations in the fluorescence image through deconvolution. Overlaying the aberration-corrected fluorescence image on top of the high-resolution bright-field image can be done with accurate spatial correspondence. This can provide means to identifying fluorescent regions of interest within the context of the sample's bright-field information. An experimental demonstration successfully improves the bright-field resolution of fixed, stained and fluorescently tagged HeLa cells by a factor of 4.9, and reduces the error caused by aberrations in a fluorescence image by 31%, over a field of view of 6.2 mm by 9.3 mm. For optimal deconvolution, we show the fluorescence image needs to have a signal-to-noise ratio of ~18.
Wide aperture piezoceramic deformable mirrors for aberration correction in high-power lasers
Vadim Samarkin; Alexander Alexandrov; Gilles Borsoni; Takahisa Jitsuno; Pavel Romanov; Aleksei Rukosuev; Alexis Kudryashov
2016-01-01
The deformable mirror with the size of 410 mmstacks was developed. The results ×468 mm controlled by the bimorph piezoceramic plates and multilayer piezoceramic of the measurements of the response functions of all the actuators and of the surface shape of the deformable mirror are presented in this paper. The study of the mirror with a Fizeau interferometer and a Shack–Hartmann wavefront sensor has shown that it was possible to improve the flatness of the surface down to a residual roughness of 0.033 μm(RMS). The possibility of correction of the aberrations in high-power lasers was numerically demonstrated.
LI Li; CHEN Ying-Tian; HU Sen
2009-01-01
By using the derivative method, we obtained the same result with that of the previous work of Chen et al.in 2006.Different from the integral form, the derivative form of the surface expression published in this paper is derived from differential equation and based on the theory of non-imaging focusing heliostat proposed by Chen et al.in 2001.The comparison of the derivative form of fixed aberration correction surface has been made with that of integral form surface as well as that of spherical surface in concentrating the solar ray.
Pupil-phase optimization for extended-focus, aberration-corrected imaging systems
Prasad, Sudhakar; Pauca, V. Paul; Plemmons, Robert J.; Torgersen, Todd C.; van der Gracht, Joseph
2004-10-01
The insertion of a suitably designed phase plate in the pupil of an imaging system makes it possible to encode the depth dimension of an extended three-dimensional scene by means of an approximately shift-invariant PSF. The so-encoded image can then be deblurred digitally by standard image recovery algorithms to recoup the depth dependent detail of the original scene. A similar strategy can be adopted to compensate for certain monochromatic aberrations of the system. Here we consider two approaches to optimizing the design of the phase plate that are somewhat complementary - one based on Fisher information that attempts to reduce the sensitivity of the phase encoded image to misfocus and the other based on a minimax formulation of the sum of singular values of the system blurring matrix that attempts to maximize the resolution in the final image. Comparisons of these two optimization approaches are discussed. Our preliminary demonstration of the use of such pupil-phase engineering to successfully control system aberrations, particularly spherical aberration, is also presented.
Dong, Bing; Li, Yan; Han, Xin-li; Hu, Bin
2016-01-01
For high-speed aircraft, a conformal window is used to optimize the aerodynamic performance. However, the local shape of the conformal window leads to large amounts of dynamic aberrations varying with look angle. In this paper, deformable mirror (DM) and model-based wavefront sensorless adaptive optics (WSLAO) are used for dynamic aberration correction of an infrared remote sensor equipped with a conformal window and scanning mirror. In model-based WSLAO, aberration is captured using Lukosz mode, and we use the low spatial frequency content of the image spectral density as the metric function. Simulations show that aberrations induced by the conformal window are dominated by some low-order Lukosz modes. To optimize the dynamic correction, we can only correct dominant Lukosz modes and the image size can be minimized to reduce the time required to compute the metric function. In our experiment, a 37-channel DM is used to mimic the dynamic aberration of conformal window with scanning rate of 10 degrees per second. A 52-channel DM is used for correction. For a 128 × 128 image, the mean value of image sharpness during dynamic correction is 1.436 × 10−5 in optimized correction and is 1.427 × 10−5 in un-optimized correction. We also demonstrated that model-based WSLAO can achieve convergence two times faster than traditional stochastic parallel gradient descent (SPGD) method. PMID:27598161
Dong, Bing; Li, Yan; Han, Xin-Li; Hu, Bin
2016-09-02
For high-speed aircraft, a conformal window is used to optimize the aerodynamic performance. However, the local shape of the conformal window leads to large amounts of dynamic aberrations varying with look angle. In this paper, deformable mirror (DM) and model-based wavefront sensorless adaptive optics (WSLAO) are used for dynamic aberration correction of an infrared remote sensor equipped with a conformal window and scanning mirror. In model-based WSLAO, aberration is captured using Lukosz mode, and we use the low spatial frequency content of the image spectral density as the metric function. Simulations show that aberrations induced by the conformal window are dominated by some low-order Lukosz modes. To optimize the dynamic correction, we can only correct dominant Lukosz modes and the image size can be minimized to reduce the time required to compute the metric function. In our experiment, a 37-channel DM is used to mimic the dynamic aberration of conformal window with scanning rate of 10 degrees per second. A 52-channel DM is used for correction. For a 128 × 128 image, the mean value of image sharpness during dynamic correction is 1.436 × 10(-5) in optimized correction and is 1.427 × 10(-5) in un-optimized correction. We also demonstrated that model-based WSLAO can achieve convergence two times faster than traditional stochastic parallel gradient descent (SPGD) method.
A color correction algorithm for noisy multi-view images
Feng Shao; Gangyi Jiang; Mei Yu; Ken Chen
2007-01-01
A novel color correction algorithm for noisy multi-view images is presented. The key idea is to use the improved Karhunen-Loeve (K-L) transform to obtain correction matrix that can eliminate noise effect to the fullest extent. Noise variance estimation is first performed in the algorithm. In the end, wavelet transform is applied to denoise the corrected image. Experimental results show that, compared with traditional correction method, a well-performed correction result is achieved using the proposed method,and the visual effect of the denoised corrected image is almost consistent with ideal corrected image.
Li, Feng; Geng, Chao; Li, Xinyang; Qiu, Qi
2016-10-01
Recently developed adaptive fiber laser array technique provides a promising way incorporating aberrations correction with laser beams transmission. Existing researches are focused on sub-aperture low order aberrations (pistons and tips/tilts) compensation and got excellent correction results for weak and moderate turbulence in short range. While such results are not adequate for future laser applications which face longer range and stronger turbulence. So sub-aperture high aberrations compensation is necessary. Relationship between corrigible orders of sub-aperture aberrations and far-field metrics as power-in-the-bucket (PIB) and Strehl ratio is investigated with numeric simulation in this paper. Numerical investigation results shows that increment in array number won't result in effective improvement of the far-field metric if sub-aperture size is fixed. Low order aberrations compensation in sub-apertures gets its best performances only when turbulence strength is weak. Pistons compensation becomes invalid and higher order aberrations compensation is necessary when turbulence gets strong enough. Cost functions of the adaptive fiber laser array with high order aberrations correction in sub-apertures are defined and the optimum corrigible orders are discussed. Results shows that high order (less than first ten Zernike orders) compensation is acceptable where balance between increment of the far-field metric and the cost and complexity of the system could be reached.
SMART:. An Aberration-Corrected XPEEM/LEEM with Energy Filter
Wichtendahl, R.; Fink, R.; Kuhlenbeck, H.; Preikszas, D.; Rose, H.; Spehr, R.; Hartel, P.; Engel, W.; Schlögl, R.; Freund, H.-J.; Bradshaw, A. M.; Lilienkamp, G.; Schmidt, Th.; Bauer, E.; Benner, G.; Umbach, E.
A new UHV spectroscopic X-ray photoelectron emission and low energy electron microscope is presently under construction for the installation at the PM-6 soft X-ray undulator beamline at BESSY II. Using a combination of a sophisticated magnetic beam splitter and an electrostatic tetrode mirror, the spherical and chromatic aberrations of the objective lens are corrected and thus the lateral resolution and sensitivity of the instrument improved. In addition a corrected imaging energy filter (a so-called omega filter) allows high spectral resolution (ΔE=0.1 eV) in the photoemission modes and back-ground suppression in LEEM and small-spot LEED modes. The theoretical prediction for the lateral resolution is 5 Å a realistic goal is about 2 nm. Thus, a variety of electron spectroscopies (XAS, XPS, UPS, XAES) and electron diffraction (LEED, LEEM) or reflection techniques (MEM) will be available with spatial resolution unreached so far.
Lindsey, Brooks D; Smith, Stephen W
2013-03-01
Having previously presented the ultrasound brain helmet, a system for simultaneous 3-D ultrasound imaging via both temporal bone acoustic windows, the scanning geometry of this system is utilized to allow each matrix array to serve as a correction source for the opposing array. Aberration is estimated using cross-correlation of RF channel signals, followed by least mean squares solution of the resulting overdetermined system. Delay maps are updated and real-time 3-D scanning resumes. A first attempt is made at using multiple arrival time maps to correct multiple unique aberrators within a single transcranial imaging volume, i.e., several isoplanatic patches. This adaptive imaging technique, which uses steered unfocused waves transmitted by the opposing, or beacon, array, updates the transmit and receive delays of 5 isoplanatic patches within a 64° x 64° volume. In phantom experiments, color flow voxels above a common threshold have also increased by an average of 92%, whereas color flow variance decreased by an average of 10%. This approach has been applied to both temporal acoustic windows of two human subjects, yielding increases in echo brightness in 5 isoplanatic patches with a mean value of 24.3 ± 9.1%, suggesting that such a technique may be beneficial in the future for performing noninvasive 3-D color flow imaging of cerebrovascular disease, including stroke.
Qu, Xiaolei; Azuma, Takashi; Lin, Hongxiang; Imoto, Haruka; Tamano, Satoshi; Takagi, Shu; Umemura, Shin-Ichiro; Sakuma, Ichiro; Matsumoto, Yoichiro
2016-04-01
Reflection image from ultrasound computed tomography (USCT) system can be obtained by synthetic aperture technique, however its quality is decreased by phase aberration caused by inhomogeneous media. Therefore, phase aberration correction is important to improve image quality. In this study, multi-stencils fast marching method (MSFMM) is employed for phase correction. The MSFMM is an accurate and fast solution of Eikonal equation which considers the refraction. The proposed method includes two steps. First, the MSFMM is used to compute sound propagation time from each element to each image gird point using sound speed image of USCT. Second, synthetic aperture technique is employed to obtain reflection image using the computed propagation time. To evaluate the proposed method, both numerical simulation and phantom experiment were conducted. With regard to numerical simulation, both quantitative and qualitative comparisons between reflection images with and without phase aberration correction were given. In the quantitative comparison, the diameters of point spread function (PSF) in reflection images of a two layer structure were presented. In the qualitative comparison, reflection images of simple circle and complex breast modes with phase aberration correction show higher quality than that without the correction. In respect to phantom experiment, a piece of breast phantom with artificial glandular structure inside was scanned by a USCT prototype, and the artificial glandular structure is able to be visible more clearly in the reflection image with phase aberration correction than in that without the correction. In this study, a phase aberration correction method by the MSFMM are proposed for reflection image of the USCT.
Linck, Martin, E-mail: linck@ceos-gmbh.de [CEOS GmbH, Englerstr. 28, D-69126 Heidelberg (Germany)
2013-01-15
Amongst the impressive improvements in high-resolution electron microscopy, the Cs-corrector also has significantly enhanced the capabilities of off-axis electron holography. Recently, it has been shown that the signal above noise in the reconstructable phase can be significantly improved by combining holography and hardware aberration correction. Additionally, with a spherical aberration close to zero, the traditional optimum focus for recording high-resolution holograms ('Lichte's defocus') has become less stringent and both, defocus and spherical aberration, can be selected freely within a certain range. This new degree of freedom can be used to improve the signal resolution in the holographically reconstructed object wave locally, e.g. at the atomic positions. A brute force simulation study for an aberration corrected 200 kV TEM is performed to determine optimum values for defocus and spherical aberration for best possible signal to noise in the reconstructed atomic phase signals. Compared to the optimum aberrations for conventional phase contrast imaging (NCSI), which produce 'bright atoms' in the image intensity, the resulting optimum values of defocus and spherical aberration for off-axis holography enable 'black atom contrast' in the hologram. However, they can significantly enhance the local signal resolution at the atomic positions. At the same time, the benefits of hardware aberration correction for high-resolution off-axis holography are preserved. It turns out that the optimum is depending on the object and its thickness and therefore not universal. -- Highlights: Black-Right-Pointing-Pointer Optimized aberration parameters for high-resolution off-axis holography. Black-Right-Pointing-Pointer Simulation and analysis of noise in high-resolution off-axis holograms. Black-Right-Pointing-Pointer Improving signal resolution in the holographically reconstructed phase shift. Black-Right-Pointing-Pointer Comparison of &apos
Hytch, M J; Houdellier, F; Snoeck, E; Huee, F, E-mail: hytch@cemes.f [CEMES-CNRS, 29 rue Jeanne Marvig, 31055 Toulouse (France)
2010-07-01
We present details of the new electron holographic dark-field technique (HoloDark) for mapping strain in nanostructures. A diffracted beam emanating from an unstrained region of crystal is interfered (with the aid of an electrostatic biprism) with a diffracted beam from the strained region of interest. Geometric phase analysis (GPA) of the holographic fringes determines the relative deformation of the two crystalline lattices. Strain can be measured to high precision, with nanometre spatial resolution and for micron fields of view. Experiments are carried out on the SACTEM-Toulouse, a Tecnai F20 (FEI) equipped with imaging aberration corrector (CEOS), field-emission gun and rotatable biprism (FEI). We operate the microscope in free-lens control with the main objective lens switched off and using the corrector transfer lenses as a Lorentz lens. We will present measurements of strain in test nanostructures and show how artefacts from thickness variations can be removed. Finally, we show our first results using a recently developed aberration-corrected Lorentz mode (CEOS).
Wüstner, Daniel; Faergeman, Nils J
2008-08-01
Intrinsically fluorescent sterols, like dehydroergosterol (DHE), mimic cholesterol closely and are therefore suitable to determine cholesterol transport by fluorescence microscopy. Disadvantages of DHE are its low quantum yield, rapid bleaching, and the fact that its excitation and emission is in the UV region of the spectrum. Thus, one has to deal with chromatic aberration and low signal-to-noise ratio. We developed a method to correct for chromatic aberration between the UV channel and the red/green channel in multicolor imaging of DHE compared with the lipid droplet marker Nile Red in living macrophage foam cells and in adipocytes. We used deconvolution microscopy and developed image segmentation techniques to assess the DHE content of lipid droplets in both cell types in an automated manner. Pulse-chase studies and colocalization analysis were performed to monitor the redistribution of DHE upon adipocyte differentiation. DHE is targeted to transferrin-positive recycling endosomes in preadipocytes but associates with droplets in mature adipocytes. Only in adipocytes but not in foam cells fluorescent sterol was confined to the droplet-limiting membrane. We developed an approach to visualize and quantify sterol content of lipid droplets in living cells with potential for automated high content screening of cellular sterol transport.
Zawadzki, Robert J; Cense, Barry; Zhang, Yan; Choi, Stacey S; Miller, Donald T; Werner, John S
2008-05-26
We have developed an improved adaptive optics - optical coherence tomography (AO-OCT) system and evaluated its performance for in vivo imaging of normal and pathologic retina. The instrument provides unprecedented image quality at the retina with isotropic 3D resolution of 3.5 x 3.5 x 3.5 microm(3). Critical to the instrument's resolution is a customized achromatizing lens that corrects for the eye's longitudinal chromatic aberration and an ultra broadband light source (Delta lambda=112 nm lambda(0)= approximately 836 nm). The eye's transverse chromatic aberrations is modeled and predicted to be sufficiently small for the imaging conditions considered. The achromatizing lens was strategically placed at the light input of the AO-OCT sample arm. This location simplifies use of the achromatizing lens and allows straightforward implementation into existing OCT systems. Lateral resolution was achieved with an AO system that cascades two wavefront correctors, a large stroke bimorph deformable mirror (DM) and a micro-electromechanical system (MEMS) DM with a high number of actuators. This combination yielded diffraction-limited imaging in the eyes examined. An added benefit of the broadband light source is the reduction of speckle size in the axial dimension. Additionally, speckle contrast was reduced by averaging multiple B-scans of the same proximal patch of retina. The combination of improved micron-scale 3D resolution, and reduced speckle size and contrast were found to significantly improve visibility of microscopic structures in the retina.
Prospects for versatile phase manipulation in the TEM: Beyond aberration correction
Guzzinati, Giulio; Clark, Laura; Béché, Armand; Juchtmans, Roeland; Van Boxem, Ruben [EMAT, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium); Mazilu, Michael [SUPA, School of Physics and Astronomy, University of St Andrews, St Andrews KY16 9SS (United Kingdom); Verbeeck, Jo, E-mail: jo.verbeeck@uantwerpen.be [EMAT, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium)
2015-04-15
In this paper we explore the desirability of a transmission electron microscope in which the phase of the electron wave can be freely controlled. We discuss different existing methods to manipulate the phase of the electron wave and their limitations. We show how with the help of current techniques the electron wave can already be crafted into specific classes of waves each having their own peculiar properties. Assuming a versatile phase modulation device is feasible, we explore possible benefits and methods that could come into existence borrowing from light optics where the so-called spatial light modulators provide programmable phase plates for quite some time now. We demonstrate that a fully controllable phase plate building on Harald Rose's legacy in aberration correction and electron optics in general would open an exciting field of research and applications. - Highlights: • We offer a review of available phase manipulation techniques. • We demonstrate a method for producing Airy waves through aberration manipulation. • We outline hypothetical applications of arbitrary phase manipulation methods.
Computerized tomography using a modified orthogonal tangent correction algorithm.
Hsia, T C; Smith, S C; Lantz, B M
1976-10-01
A modified orthogonal tangent correction algorithm is presented for computerized tomography. The algorithm uses four X-rays scans spaced 45 degrees apart, to reconstruct a transverse axial image. The reconstruction procedure is interative in which image matrix elements are corrected by alternately matching the two sets of orthogonal scan data. The algorithm has been applied to phantom data as well as to video recorded fluoroscopic data.
Weimin Wang
2014-02-01
Full Text Available A 45-element continuous facesheet surface micromachined deformable mirror (DM is presented and is fabricated using the PolyMUMPs multi-user micro-electro-mechanical system processes. The effects of the structural parameters on the characteristics of the DM, such as its stroke, frequency and actuator coupling, are analyzed. In addition, the DM design has also been verified through experimental testing. This DM prototype has a surface figure of 0.5 μm and a fill factor of 95%. The DM can provide a 0.6 μm stroke with 5.9% actuator coupling. A static aberration correction based on this DM is also demonstrated, which acts as a reference for the potential adaptive optics (AO applications of the device.
Fartoukh, S
2010-01-01
The chromatic aberrations induced by low-β insertions can seriously limit the performance of circular colliders. The impact is twofold: (1) a substantial off-momentum beta-beating wave traveling around the ring and leading to a net reduction of the mechanical aperture of the low-beta quadrupoles but also impacting on the hierarchy of the collimator and protection devices of the machine, (2) a huge non-linear chromaticity which, when combined with the magnetic imperfections of the machine, could substantially reduce the momentum acceptance of the ring by pushing slightly off-momentum particles towards non-linear resonances. These effects will be analyzed and illustrated in the framework of the LHC insertions upgrade Phase I [1] and a strategy for correction will be developed, requiring a deep modification of the LHC overall optics.
Fartoukh, S
2010-01-01
The chromatic aberrations induced by low-β insertions can seriously limit the performance of circular colliders. The impact is twofold: (1) a substantial off-momentum beta-beating wave traveling around the ring and leading to a net reduction of the mechanical aperture of the lowbeta quadrupoles but also impacting on the hierarchy of the collimator and protection devices of the machine, (2) a huge non-linear chromaticity which, when combined with the magnetic imperfections of the machine, could substantially reduce the momentum acceptance of the ring by pushing slightly off-momentum particles towards non-linear resonances. These effects will be analyzed and illustrated in the framework of the LHC insertions upgrade Phase I [1] and a strategy for correction will be developed, requiring a deep modification of the LHC overall optics.
Perfect X-ray focusing via fitting corrective glasses to aberrated optics.
Seiboth, Frank; Schropp, Andreas; Scholz, Maria; Wittwer, Felix; Rödel, Christian; Wünsche, Martin; Ullsperger, Tobias; Nolte, Stefan; Rahomäki, Jussi; Parfeniukas, Karolis; Giakoumidis, Stylianos; Vogt, Ulrich; Wagner, Ulrich; Rau, Christoph; Boesenberg, Ulrike; Garrevoet, Jan; Falkenberg, Gerald; Galtier, Eric C; Ja Lee, Hae; Nagler, Bob; Schroer, Christian G
2017-03-01
Due to their short wavelength, X-rays can in principle be focused down to a few nanometres and below. At the same time, it is this short wavelength that puts stringent requirements on X-ray optics and their metrology. Both are limited by today's technology. In this work, we present accurate at wavelength measurements of residual aberrations of a refractive X-ray lens using ptychography to manufacture a corrective phase plate. Together with the fitted phase plate the optics shows diffraction-limited performance, generating a nearly Gaussian beam profile with a Strehl ratio above 0.8. This scheme can be applied to any other focusing optics, thus solving the X-ray optical problem at synchrotron radiation sources and X-ray free-electron lasers.
Wang, Peng; Behan, Gavin; Kirkland, Angus I; Nellist, Peter D; Cosgriff, Eireann C; D'Alfonso, Adrian J; Morgan, Andrew J; Allen, Leslie J; Hashimoto, Ayako; Takeguchi, Masaki; Mitsuishi, Kazutaka; Shimojo, Masayuki
2011-06-01
Scanning confocal electron microscopy (SCEM) offers a mechanism for three-dimensional imaging of materials, which makes use of the reduced depth of field in an aberration-corrected transmission electron microscope. The simplest configuration of SCEM is the bright-field mode. In this paper we present experimental data and simulations showing the form of bright-field SCEM images. We show that the depth dependence of the three-dimensional image can be explained in terms of two-dimensional images formed in the detector plane. For a crystalline sample, this so-called probe image is shown to be similar to a conventional diffraction pattern. Experimental results and simulations show how the diffracted probes in this image are elongated in thicker crystals and the use of this elongation to estimate sample thickness is explored.
Model-based aberration correction in a closed-loop wavefront-sensor-less adaptive optics system.
Song, H; Fraanje, R; Schitter, G; Kroese, H; Vdovin, G; Verhaegen, M
2010-11-08
In many scientific and medical applications, such as laser systems and microscopes, wavefront-sensor-less (WFSless) adaptive optics (AO) systems are used to improve the laser beam quality or the image resolution by correcting the wavefront aberration in the optical path. The lack of direct wavefront measurement in WFSless AO systems imposes a challenge to achieve efficient aberration correction. This paper presents an aberration correction approach for WFSlss AO systems based on the model of the WFSless AO system and a small number of intensity measurements, where the model is identified from the input-output data of the WFSless AO system by black-box identification. This approach is validated in an experimental setup with 20 static aberrations having Kolmogorov spatial distributions. By correcting N=9 Zernike modes (N is the number of aberration modes), an intensity improvement from 49% of the maximum value to 89% has been achieved in average based on N+5=14 intensity measurements. With the worst initial intensity, an improvement from 17% of the maximum value to 86% has been achieved based on N+4=13 intensity measurements.
Marcos, Susana; Sawides, Lucie; Gambra, Enrique; Dorronsoro, Carlos
2008-10-06
We evaluated the visual benefit of correcting astigmatism and high-order aberrations with adaptive optics (AO) on visual acuity (VA) measured at 7 different luminances (ranging from 0.8 to 50 cd/m(2)) and two contrast polarities (black letters on white background, BoW, and white letters on black background, WoB) on 7 subjects. For the BoW condition, VA increased with background luminance in both natural and AO-corrected conditions, and there was a benefit of AO correction at all luminances (by a factor of 1.29 on average across luminances). For WoB VA increased with foreground luminance but decreased for the highest luminances. In this reversed polarity condition AO correction increased VA by a factor of 1.13 on average and did not produce a visual benefit at high luminances. The improvement of VA (averaged across conditions) was significantly correlated (p = 0.04) with the amount of corrected aberrations (in terms of Strehl ratio). The improved performance with WoB targets with respect to BoW targets is decreased when correcting aberrations, suggesting a role of ocular aberrations in the differences in visual performance between contrast polarities.
Nobuo Tanaka
2008-01-01
Full Text Available The present status of Cs-corrected TEM/STEM is described from the viewpoint of the observation of nanomaterials. Characteristic features in TEM and STEM are explained using the experimental data obtained by our group and other research groups. Cs correction up to the 3rd-order aberration of an objective lens has already been established and research interest is focused on correcting the 5th-order spherical aberration and the chromatic aberration in combination with the development of a monochromator below an electron gun for smaller point-to-point resolution in optics. Another fundamental area of interest is the limitation of TEM and STEM resolution from the viewpoint of the scattering of electrons in crystals. The minimum size of the exit-wave function below samples undergoing TEM imaging is determined from the calculation of scattering around related atomic columns in the crystals. STEM does not have this limitation because the resolution is, in principle, determined by the probe size. One of the future prospects of Cs-corrected TEM/STEM is the possibility of extending the space around the sample holder by correcting the chromatic and spherical aberrations. This wider space will contribute to the ease of performing in situ experiments and various combinations of TEM and other analysis methods. High-resolution, in situ dynamic and 3D observations/analysis are the most important keywords in the next decade of high-resolution electron microscopy.
Zhou, Wu
In this thesis, aberration corrected STEM imaging and chemical analysis techniques have been extensively applied in the structural and chemical characterization of supported tungsten oxide catalysts in an attempt to reveal the structure-activity relationships at play in these catalyst systems. The supported WO3/ZrO2 solid acid catalyst system is a major focal point of this thesis, and detailed aberration-corrected STEM-HAADF imaging studies were performed on a systematic set of catalysts showing different level of catalytic performance. The nature of the catalytically most active WOx species was identified by correlating structural information, obtained from STEM-HAADF and in-situ optical spectroscopy studies, with catalytic testing results. Specifically, ˜1nm distorted Zr-WOx mixed oxide clusters were identified to be the most active species for both the methanol dehydration and n-pentane isomerization reactions in the WO3/ZrO2 catalyst system. The use of amorphous zirconia as a precursor support material makes it much easier to extract and incorporate Zr cations into the surface WOx clusters during calcination. The calcination temperature was also identified to also play an important role in the formation of these most active Zr-WOx clusters. When the calcination temperature is comparable to or higher than the 896K Huttig temperature of ZrO2 (at which surface ZrO x species have sufficient mobility to agglomerate and sinter), the chance for successful surface WOx and ZrOx intermixing is significantly increased. Based on this perceived structure-activity relationship, several new catalyst synthesis strategies were developed in an attempt to optimize the catalytic performance of WOx-based catalysts. We have demonstrated in Chapter 3 that co-impregnation of WOx and ZrOx precursors onto an inactive model WO3/ZrO2 catalyst, followed by a calcination treatment above the 896K Huttig temperature of ZrO 2, promotes the surface diffusion of ZrO2 and intermixing of Zr
Schmidt, Th., E-mail: schmidtt@fhi-berlin.mpg.de [Fritz Haber Institute of the Max Planck Society, Department of Chemical Physics, Faradayweg 4-6, D-14195 Berlin (Germany); Sala, A.; Marchetto, H. [Fritz Haber Institute of the Max Planck Society, Department of Chemical Physics, Faradayweg 4-6, D-14195 Berlin (Germany); Umbach, E. [Karlsruhe Institute of Technology, 76021 Karlsruhe (Germany); Freund, H.-J. [Fritz Haber Institute of the Max Planck Society, Department of Chemical Physics, Faradayweg 4-6, D-14195 Berlin (Germany)
2013-03-15
The positive effect of double aberration correction in x-ray induced Photoelectron Emission Microscopy (XPEEM) has been successfully demonstrated for both, the lateral resolution and the transmission, using the Au 4f XPS peak for element specific imaging at a kinetic energy of 113 eV. The lateral resolution is improved by a factor of four, compared to a non-corrected system, whereas the transmission is enhanced by a factor of 5 at a moderate resolution of 80 nm. With an optimized system setting, a lateral resolution of 18 nm could be achieved, which is up to now the best value reported for energy filtered XPEEM imaging. However, the absolute resolution does not yet reach the theoretical limit of 2 nm, which is due to space charge limitation. This occurs along the entire optical axis up to the contrast aperture. In XPEEM the pulsed time structure of the exciting soft x-ray light source causes a short and highly intense electron pulse, which results in an image blurring. In contrast, the imaging with elastically reflected electrons in the low energy electron microscopy (LEEM) mode yields a resolution clearly below 5 nm. Technical solutions to reduce the space charge effect in an aberration-corrected spectro-microscope are discussed. - Highlights: ► First successful double aberration correction in XPEEM. ► Improvement of resolution and transmission by aberration correction. ► Lateral resolution of 18 nm in energy filtered XPEEM is the best up to now reported value. ► First investigation of space charge effects in aberrations corrected PEEM.
Model-based aberration correction in a closed-loop wavefront-sensor-less adaptive optics system
Song, H.; Fraanje, R.; Schitter, G.; Kroese, H.; Vdovin, G.; Verhaegen, M.
2010-01-01
In many scientific and medical applications, such as laser systems and microscopes, wavefront-sensor-less (WFSless) adaptive optics (AO) systems are used to improve the laser beam quality or the image resolution by correcting the wavefront aberration in the optical path. The lack of direct wavefront
Aberration-corrected electron microscopy of MnAs and As nanocrystals and voids in annealed (Ga,Mn)As
Kovács, András; Kasama, Takeshi; Sadowski, J.
2011-01-01
Aberration-corrected transmission electron microscopy is used to study voids and nano-crystalline MnAs and As phases formed during the annealing of Mn-doped GaAs. The effects of defocus and inner annular dark-field detector semi-angle on contrast of the nanocrystals are discussed....
Chih-Ta Yen
2015-09-01
Full Text Available A complex intraocular lens (IOL design involving numerous uncertain variables is proposed. We integrated a genetic algorithm (GA with the commercial optical design software of (CODE V to design a multifocal IOL for the human eye. We mainly used an aspherical lens in the initial state to the crystalline type; therefore, we used the internal human eye model in the software. The proposed optimized algorithm employs a GA method for optimally simulating the focusing function of the human eye; in this method, the thickness and curvature of the anterior lens and the posterior part of the IOL were varied. A comparison of the proposed GA-designed IOLs and those designed using a CODE V built-in optimal algorithm for 550 degrees myopia and 175 degrees astigmatism conditions of the human eye for pupil size 6 mm showed that the proposed IOL design improved the spot size of root mean square (RMS, tangential coma (TCO and modulation transfer function (MTF at a spatial frequency of 30 with a pupil size of 6 mm by approximately 17%, 43% and 35%, respectively. However, the worst performance of spherical aberration (SA was lower than 46%, because the optical design involves a tradeoff between all aberrations. Compared with the traditional CODE V built-in optimal scheme, the proposed IOL design can efficiently improve the critical parameters, namely TCO, RMS, and MTF.
Camera processing with chromatic aberration.
Korneliussen, Jan Tore; Hirakawa, Keigo
2014-10-01
Since the refractive index of materials commonly used for lens depends on the wavelengths of light, practical camera optics fail to converge light to a single point on an image plane. Known as chromatic aberration, this phenomenon distorts image details by introducing magnification error, defocus blur, and color fringes. Though achromatic and apochromatic lens designs reduce chromatic aberration to a degree, they are complex and expensive and they do not offer a perfect correction. In this paper, we propose a new postcapture processing scheme designed to overcome these problems computationally. Specifically, the proposed solution is comprised of chromatic aberration-tolerant demosaicking algorithm and post-demosaicking chromatic aberration correction. Experiments with simulated and real sensor data verify that the chromatic aberration is effectively corrected.
Ferraro, P; Miccio, L; Grilli, S; Paturzo, M; De Nicola, S; Finizio, A; Osellame, R; Laporta, P
2007-10-29
Quantitative Phase Microscopy (QPM) by interferometric techniques can require a multiwavelength configuration to remove 2pi ambiguity and improve accuracy. However, severe chromatic aberration can affect the resulting phase-contrast map. By means of classical interference microscope configuration it is quite unpractical to correct such aberration. We propose and demonstrate that by Digital Holography (DH) in a microscope configuration it is possible to clear out the QPM map from the chromatic aberration in a simpler and more effective way with respect to other approaches. The proposed method takes benefit of the unique feature of DH to record in a plane out-of-focus and subsequently reconstruct numerically at the right focal image plane. In fact, the main effect of the chromatic aberration is to shift differently the correct focal image plane at each wavelength and this can be readily compensated by adjusting the corresponding reconstruction distance for each wavelength. A procedure is described in order to determine easily the relative focal shift among different imaging wavelengths by performing a scanning of the numerical reconstruction along the optical axis, to find out the focus and to remove at the same time the chromatic aberration.
Stochastic Formal Correctness of Numerical Algorithms
Daumas, Marc; Lester, David; Martin-Dorel, Erik; Truffert, Annick
2009-01-01
We provide a framework to bound the probability that accumulated errors were never above a given threshold on numerical algorithms. Such algorithms are used for example in aircraft and nuclear power plants. This report contains simple formulas based on Levy's and Markov's inequalities and it presents a formal theory of random variables with a special focus on producing concrete results. We selected four very common applications that fit in our framework and cover the common practices of systems that evolve for a long time. We compute the number of bits that remain continuously significant in the first two applications with a probability of failure around one out of a billion, where worst case analysis considers that no significant bit remains. We are using PVS as such formal tools force explicit statement of all hypotheses and prevent incorrect uses of theorems.
Beam hardening correction algorithm in microtomography images
Sales, Erika S.; Lima, Inaya C.B.; Lopes, Ricardo T., E-mail: esales@con.ufrj.b, E-mail: ricardo@lin.ufrj.b [Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Lab. de Instrumentacao Nuclear; Assis, Joaquim T. de, E-mail: joaquim@iprj.uerj.b [Universidade do Estado do Rio de Janeiro (UERJ), Nova Friburgo, RJ (Brazil). Inst. Politecnico. Dept. de Engenharia Mecanica
2009-07-01
Quantification of mineral density of bone samples is directly related to the attenuation coefficient of bone. The X-rays used in microtomography images are polychromatic and have a moderately broad spectrum of energy, which makes the low-energy X-rays passing through a sample to be absorbed, causing a decrease in the attenuation coefficient and possibly artifacts. This decrease in the attenuation coefficient is due to a process called beam hardening. In this work the beam hardening of microtomography images of vertebrae of Wistar rats subjected to a study of hyperthyroidism was corrected by the method of linearization of the projections. It was discretized using a spectrum in energy, also called the spectrum of Herman. The results without correction for beam hardening showed significant differences in bone volume, which could lead to a possible diagnosis of osteoporosis. But the data with correction showed a decrease in bone volume, but this decrease was not significant in a confidence interval of 95%. (author)
A NOVEL ADAPTIVE ALGORITHM OF CPE CORRECTION FOR OFDM SYSTEMS
Cai Zejian; Ge Jianhua; Wu Guohang
2005-01-01
On the basis of the analysis of the effect of PHase Noise (PHN) and Common Phase Error (CPE) on Orthogonal Frequency Division Multiplexing (OFDM) systems, a cost function is constructed. By the cost function and the idea of Least-Mean-Square (LMS) adaptive algorithm, the adaptive algorithm for the correction of CPE is presented. The simulations have been performed to investigate the performance for tracking PHN and estimating CPE, the results show that the algorithm performs soundly.
Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates
Liliana Carreño-Fuentes
2016-08-01
Full Text Available Viral templates are highly versatile biotemplates used for the synthesis of nanostructured materials. Rotavirus VP6 self-assembles into nanotubular hollow structures with well-defined diameters and variable lengths, serving as a nucleic acid-free biotemplate to synthesize metal nanoparticles of controlled size, shape, and orientation. Molecular docking simulations show that exposed residues (H173-S240-D242 and N200-N310 of VP6 have the ability to specifically bind Pd(II ions, which serve as nucleation sites for the growth and stabilization of palladium nanoclusters. Using VP6 nanotubes as biotemplates allows for obtaining small Pd particles of 1–5 nm in diameter. Advanced electron microscopy imaging and characterization through ultra-high-resolution field-emission scanning electron microscopy (UHR-FE-SEM and spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM at a low voltage dose (80 kV reveals, with high spatial resolution, the structure of Pd nanoparticles attached to the macromolecular biotemplates.
Chromatic-aberration-corrected diffractive lenses for ultra-broadband focusing
Wang, Peng; Mohammad, Nabil; Menon, Rajesh
2016-02-01
We exploit the inherent dispersion in diffractive optics to demonstrate planar chromatic-aberration-corrected lenses. Specifically, we designed, fabricated and characterized cylindrical diffractive lenses that efficiently focus the entire visible band (450 nm to 700 nm) onto a single line. These devices are essentially pixelated, multi-level microstructures. Experiments confirm an average optical efficiency of 25% for a three-wavelength apochromatic lens whose chromatic focus shift is only 1.3 μm and 25 μm in the lateral and axial directions, respectively. Super-achromatic performance over the continuous visible band is also demonstrated with averaged lateral and axial focus shifts of only 1.65 μm and 73.6 μm, respectively. These lenses are easy to fabricate using single-step grayscale lithography and can be inexpensively replicated. Furthermore, these devices are thin (<3 μm), error tolerant, has low aspect ratio (<1:1) and offer polarization-insensitive focusing, all significant advantages compared to alternatives that rely on metasurfaces. Our design methodology offers high design flexibility in numerical aperture and focal length, and is readily extended to 2D.
Yoshida, K.; Shiju, N. R.; Brown, D. R.; Boyes, E. D.; Gai, P. L.
2010-07-01
We report highly active tungstated zirconia nanocatalysts for the synthesis of paracetamol by Beckmann rearrangement of 4-hydroxyacetophenone oxime. Double aberration-corrected (2AC)-TEM/STEM studies were performed in a JEOL 2200FS FEG TEM/STEM at the 1 Angstrom (1 Å = 0.1 nanometer) level. Observations at close to zero defocus were carried out using the AC-TEM as well as AC-STEM including high angle annular dark field (HAADF) imaging, from the same areas of the catalyst crystallites. The studies from the same areas have revealed the location and the nanostructure of the polytungstate species (clusters) and the nanograins of zirconia. The AC (S)TEM was crucial to observe the nanostructure and location of polytungstate clusters on the zirconia grains. Polytungstate clusters as small as 0.5 nm have been identified using the HAADF-STEM. The nanostructures of the catalyst and the W surface density have been correlated with paracetamol reaction studies. The results demonstrate the nature of active sites and high activity of the tungstated zirconia nanocatalyst, which is an environmentally clean alternative to the current homogeneous process.
Shah, A B; Ramasse, Q M; Wen, J G; Bhattacharya, A; Zuo, J M
2011-08-01
The resolution of electron energy loss spectroscopy (EELS) is limited by delocalization of inelastic electron scattering rather than probe size in an aberration corrected scanning transmission electron microscope (STEM). In this study, we present an experimental quantification of EELS spatial resolution using chemically modulated 2×(LaMnO(3))/2×(SrTiO(3)) and 2×(SrVO(3))/2×(SrTiO(3)) superlattices by measuring the full width at half maxima (FWHM) of integrated Ti M(2,3), Ti L(2,3), V L(2,3), Mn L(2,3), La N(4,5), La N(2,3) La M(4,5) and Sr L(3) edges over the superlattices. The EELS signals recorded using large collection angles are peaked at atomic columns. The FWHM of the EELS profile, obtained by curve-fitting, reveals a systematic trend with the energy loss for the Ti, V, and Mn edges. However, the experimental FWHM of the Sr and La edges deviates significantly from the observed experimental tendency.
Wang, Peng; Behan, Gavin; Kirkland, Angus I. [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Nellist, Peter D., E-mail: peter.nellist@materials.ox.ac.uk [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Cosgriff, Eireann C.; D' Alfonso, Adrian J.; Morgan, Andrew J.; Allen, Leslie J. [School of Physics, University of Melbourne, Parkville, Victoria 3010 (Australia); Hashimoto, Ayako [Advanced Nano-characterization Center, National Institute for Materials Science (NIMS), 3-13 Sakura, Tsukuba 305-0003 (Japan); Takeguchi, Masaki [Advanced Nano-characterization Center, National Institute for Materials Science (NIMS), 3-13 Sakura, Tsukuba 305-0003 (Japan); High Voltage Electron Microscopy Station, NIMS, 3-13 Sakura, Tsukuba 305-0003 (Japan); Mitsuishi, Kazutaka [Advanced Nano-characterization Center, National Institute for Materials Science (NIMS), 3-13 Sakura, Tsukuba 305-0003 (Japan); Quantum Dot Research Center, NIMS, 3-13 Sakura, Tsukuba 305-0003 (Japan); Shimojo, Masayuki [High Voltage Electron Microscopy Station, NIMS, 3-13 Sakura, Tsukuba 305-0003 (Japan); Advanced Science Research Laboratory, Saitama Institute of Technology, 1690 Fusaiji, Fukaya 369-0293 (Japan)
2011-06-15
Scanning confocal electron microscopy (SCEM) offers a mechanism for three-dimensional imaging of materials, which makes use of the reduced depth of field in an aberration-corrected transmission electron microscope. The simplest configuration of SCEM is the bright-field mode. In this paper we present experimental data and simulations showing the form of bright-field SCEM images. We show that the depth dependence of the three-dimensional image can be explained in terms of two-dimensional images formed in the detector plane. For a crystalline sample, this so-called probe image is shown to be similar to a conventional diffraction pattern. Experimental results and simulations show how the diffracted probes in this image are elongated in thicker crystals and the use of this elongation to estimate sample thickness is explored. -- Research Highlights: {yields} The confocal probe image in a scanning confocal electron microscopy image reveals information about the thickness and height of the crystalline layer. {yields} The form of the contrast in a three-dimensional bright-field scanning confocal electron microscopy image can be explained in terms of the confocal probe image. {yields} Despite the complicated form of the contrast in bright-field scanning confocal electron microscopy, we see that depth information is transferred on a 10 nm scale.
Mukherjee, Debangshu; Stone, Greg; Moon, Eun Ju; Young, Joshua; Gopalan, Venkatraman; Rondinelli, James; May, Steven; Alem, Nasim
The brownmillerite phase A2B2O5 consists of ordered oxygen vacancies in alternate perovskite layers forming chiral tetrahedral chains. The handedness of these tetrahedral chains control the polarization of the structure. The current study focuses on 1-1 brownmillerite superlattices grown on a SrTiO3 substrates using molecular beam epitaxy. The B-site in this structure is iron throughout the superlattice film, while the A-site alternates between calcium and strontium in the superlattice layers. In this study, we use atomic resolution aberration corrected scanning transmission electron microscopy (STEM) to investigate the structure and chemistry of the film-substrate interface as well as the chemical structure of the superlattice. Atom positions are determined to measure displacement vectors of A-site cations in the superlattice structure. D.M., G.A.S., V.G. and N.A. were supported by the National Science Foundation under Grant No. DMR-1420620. E.J.M. and S.J.M. were supported by the National Science Foundation under Grant No. DMR-1151649.
Yoshida, K; Boyes, E D; Gai, P L [York JEOL Nanocentre (United Kingdom); Shiju, N R; Brown, D R, E-mail: pgb500@york.ac.u [Department of Chemical and Biological Sciences, University of Huddersfield, Huddersfield, HD1 3DH (United Kingdom)
2010-07-01
We report highly active tungstated zirconia nanocatalysts for the synthesis of paracetamol by Beckmann rearrangement of 4-hydroxyacetophenone oxime. Double aberration-corrected (2AC)-TEM/STEM studies were performed in a JEOL 2200FS FEG TEM/STEM at the 1 Angstrom (1 A = 0.1 nanometer) level. Observations at close to zero defocus were carried out using the AC-TEM as well as AC-STEM including high angle annular dark field (HAADF) imaging, from the same areas of the catalyst crystallites. The studies from the same areas have revealed the location and the nanostructure of the polytungstate species (clusters) and the nanograins of zirconia. The AC (S)TEM was crucial to observe the nanostructure and location of polytungstate clusters on the zirconia grains. Polytungstate clusters as small as 0.5 nm have been identified using the HAADF-STEM. The nanostructures of the catalyst and the W surface density have been correlated with paracetamol reaction studies. The results demonstrate the nature of active sites and high activity of the tungstated zirconia nanocatalyst, which is an environmentally clean alternative to the current homogeneous process.
Wang, Xuan-Yin; Du, Jia-Wei; Zhu, Shi-Qiang
2017-09-01
A bionic variable-focus lens with symmetrical layered structure was designed to mimic the crystalline lens. An optical imaging system based on this lens and with a symmetrical structure that mimics the human eye structure was proposed. The refractive index of the bionic variable-focus lens increases from outside to inside. The two PDMS lenses with a certain thickness were designed to improve the optical performance of the optical imaging system and minimise the gravity effect of liquid. The paper presents the overall structure of the optical imaging system and the detailed description of the bionic variable-focus lens. By pumping liquid in or out of the cavity, the surface curvatures of the rear PDMS lens were varied, resulting in a change in the focal length. The focal length range of the optical imaging system was 20.71-24.87 mm. The optical performance of the optical imaging system was evaluated by imaging experiments and analysed by ray tracing simulations. On the basis of test and simulation results, the optical performance of the system was quite satisfactory. Off-axis aberrations were well corrected, and the image quality was greatly improved.
Adaptive bad pixel correction algorithm for IRFPA based on PCNN
Leng, Hanbing; Zhou, Zuofeng; Cao, Jianzhong; Yi, Bo; Yan, Aqi; Zhang, Jian
2013-10-01
Bad pixels and response non-uniformity are the primary obstacles when IRFPA is used in different thermal imaging systems. The bad pixels of IRFPA include fixed bad pixels and random bad pixels. The former is caused by material or manufacture defect and their positions are always fixed, the latter is caused by temperature drift and their positions are always changing. Traditional radiometric calibration-based bad pixel detection and compensation algorithm is only valid to the fixed bad pixels. Scene-based bad pixel correction algorithm is the effective way to eliminate these two kinds of bad pixels. Currently, the most used scene-based bad pixel correction algorithm is based on adaptive median filter (AMF). In this algorithm, bad pixels are regarded as image noise and then be replaced by filtered value. However, missed correction and false correction often happens when AMF is used to handle complex infrared scenes. To solve this problem, a new adaptive bad pixel correction algorithm based on pulse coupled neural networks (PCNN) is proposed. Potential bad pixels are detected by PCNN in the first step, then image sequences are used periodically to confirm the real bad pixels and exclude the false one, finally bad pixels are replaced by the filtered result. With the real infrared images obtained from a camera, the experiment results show the effectiveness of the proposed algorithm.
Wang, Peng; Qi, Jia; Liu, Zhengming; Liao, Yang; Chu, Wei; Cheng, Ya
2017-01-01
Writing optical waveguides with femtosecond laser pulses provides the capability of forming three-dimensional photonic circuits for manipulating light fields in both linear and nonlinear manners. To fully explore this potential, large depths of the buried waveguides in transparent substrates are often desirable to facilitate achieving vertical integration of waveguides in a multi-layer configuration, which, however, is hampered by rapidly degraded axial resolution caused by optical aberration. Here, we show that with the correction of the spherical aberration, polarization-independent waveguides can be inscribed in a nonlinear optical crystal lithium niobate (LN) at depths up to 1400 μm, which is more than one order of magnitude deeper than the waveguides written with aberration uncorrected femtosecond laser pulses. Our technique is beneficial for applications ranging from miniaturized nonlinear light sources to quantum information processing. PMID:28112246
Kim, Taehyun; Bershteyn, Marina; Wynshaw-Boris, Anthony
2014-01-01
The fusion of the short (p) and long (q) arms of a chromosome is referred to as a "ring chromosome." Ring chromosome disorders occur in approximately 1 in 50,000-100,000 patients. Ring chromosomes can result in birth defects, mental disabilities, and growth retardation if additional genes are deleted during the formation of the ring. Due to the severity of these large-scale aberrations affecting multiple contiguous genes, no possible therapeutic strategies for ring chromosome disorders have so far been proposed. Our recent study (Bershteyn et al.) using patient-derived fibroblast lines containing ring chromosomes, found that cellular reprogramming of these fibroblasts into induced pluripotent stem cells (iPSCs) resulted in the cell-autonomous correction of the ring chromosomal aberration via compensatory uniparental disomy (UPD). These observations have important implications for studying the mechanism of chromosomal number control and may lead to the development of effective therapies for other, more common, chromosomal aberrations.
Wang, Peng; Liu, Zhengming; Liao, Yang; Chu, Wei; Cheng, Ya
2016-01-01
Writing optical waveguides with femtosecond laser pulses provides the capability of forming three-dimensional photonic circuits for manipulating light fields in both linear and nonlinear manners. To fully explore this potential, large depths of the buried waveguides in transparent substrates are often desirable to facilitate achieving vertical integration of waveguides in a multi-layer configuration, which, however, is hampered by rapidly degraded axial resolution caused by optical aberration. Here, we show that with the correction of the spherical aberration, polarization-independent waveguides can be inscribed in a nonlinear optical crystal lithium niobate (LN) at depths up to 1.4 mm, which is more than one order of magnitude deeper than the waveguides written with aberration uncorrected femtosecond laser pulses. Our technique is beneficial for applications ranging from miniaturized nonlinear light sources to quantum information processing.
MU GuoGuang; WANG ZhaoQi; LIU YongJi; QUAN Wei; WANG Yang; WANG Wei
2007-01-01
In this paper we present the recent research results in the field of vision correction and supernormal vision according to the actual measurements of the wave-front aberrations and the corneal surface topography, the clinical detection of the visual function and the laser corneal refractive surgery, and the optimization of the optical system. These include the features of the aberrations of human eye with different pupil sizes, different fields of view and temporal accommodation, the influence of the polychromatic illumination of the visible wavelength on the supernormal vision,and the effect of the existing laser corneal refractive surgery on the wave-front aberrations of the eye. It is shown that the wave-front aberration of human eye is of temporal variation and of synthesis with multi impact factors. To achieve supernormal vision, an optimum engineering data for the customized laser corneal surgery should be firstly acquired, which may involve the dynamic free-form optical surface. Although the myopia can be corrected by the laser in situ keratomileusis (LASlK) in a certain degree, it brings about negative effects under scotopic conditions.
2007-01-01
In this paper we present the recent research results in the field of vision correction and supernormal vision according to the actual measurements of the wave-front aberrations and the corneal surface topography,the clinical detection of the visual function and the laser corneal refractive surgery,and the optimization of the optical system. These include the features of the aberrations of human eye with different pupil sizes,different fields of view and temporal accommodation,the influence of the polychromatic illumination of the visible wavelength on the supernormal vision,and the effect of the existing laser corneal refractive surgery on the wave-front ab-errations of the eye. It is shown that the wave-front aberration of human eye is of temporal variation and of synthesis with multi impact factors. To achieve super-normal vision,an optimum engineering data for the customized laser corneal sur-gery should be firstly acquired,which may involve the dynamic free-form optical surface. Although the myopia can be corrected by the laser in situ keratomileusis(LASIK) in a certain degree,it brings about negative effects under scotopic condi-tions.
Correction of cell-induced optical aberrations in a fluorescence fluctuation microscope
Leroux, Charles-Edouard; Wang, Irène; Delon, Antoine
2014-01-01
We describe the effect of optical aberrations on fluorescence fluctuations microscopy (FFM), when focusing through a single living cell. FFM measurements are performed in an aqueous fluorescent solution and prove to be a highly sensitive tool to assess the optical aberrations introduced by the cell. We demonstrate an adaptive optics (AO) system to remove the aberration-related bias in the FFM measurements. Our data show that AO is not only useful when imaging deep in tissues but also when performing FFM measurements through a single cellular layer. This work paves the way for the application of FFM to complex three-dimensional multicellular samples.
Akashi, Tetsuya; Takahashi, Yoshio; Tanigaki, Toshiaki, E-mail: toshiaki.tanigaki.mv@hitachi.com; Shimakura, Tomokazu; Kawasaki, Takeshi; Furutsu, Tadao; Shinada, Hiroyuki; Osakabe, Nobuyuki [Central Research Laboratory, Hitachi, Ltd., Hatoyama 350-0395 (Japan); Müller, Heiko; Haider, Maximilian [Corrected Electron Optical Systems GmbH, Englerstr. 28, D-69126 Heidelberg (Germany); Tonomura, Akira [Central Research Laboratory, Hitachi, Ltd., Hatoyama 350-0395 (Japan); RIKEN Center for Emergent Matter Science (CEMS), Wako 351-0198 (Japan)
2015-02-16
Atomic-resolution electromagnetic field observation is critical to the development of advanced materials and to the unveiling of their fundamental physics. For this purpose, a spherical-aberration corrected 1.2-MV cold field-emission transmission electron microscope has been developed. The microscope has the following superior properties: stabilized accelerating voltage, minimized electrical and mechanical fluctuation, and coherent electron emission. These properties have enabled to obtain 43-pm information transfer. On the bases of these performances, a 43-pm resolution has been obtained by correcting lens aberrations up to the third order. Observations of GaN [411] thin crystal showed a projected atomic locations with a separation of 44 pm.
Progress on PEEM3 — An Aberration Corrected X-Ray Photoemission Electron Microscope at the ALS
MacDowell, A. A.; Feng, J.; DeMello, A.; Doran, A.; Duarte, R.; Forest, E.; Kelez, N.; Marcus, M. A.; Miller, T.; Padmore, H. A.; Raoux, S.; Robin, D.; Scholl, A.; Schlueter, R.; Schmid, P.; Stöhr, J.; Wan, W.; Wei, D. H.; Wu, Y.
2007-01-01
A new ultrahigh-resolution photoemission electron microscope called PEEM3 is being developed and built at the Advanced Light Source (ALS). An electron mirror combined with a much-simplified magnetic dipole separator is to be used to provide simultaneous correction of spherical and chromatic aberrations. It is installed on an elliptically polarized undulator (EPU) beamline, and will be operated with very high spatial resolution and high flux to study the composition, structure, electric and magnetic properties of complex materials. The instrument has been designed and is described. The instrumental hardware is being deployed in 2 phases. The first phase is the deployment of a standard PEEM type microscope consisting of the standard linear array of electrostatic electron lenses. The second phase will be the installation of the aberration corrected upgrade to improve resolution and throughput. This paper describes progress as the instrument enters the commissioning part of the first phase.
Telecentric confocal optics for aberration correction of acousto-optic tunable filters.
Suhre, Dennis R; Denes, Louis J; Gupta, Neelam
2004-02-20
A telecentric confocal optical arrangement is presented that greatly reduces the diffraction aberrations of the acousto-optic tunable filter (AOTF). Analytical expressions for the aberrations were identified based on the fundamental properties of Bragg diffraction, and additional aberrations due to focusing through the AOTF were also included. The analysis was verified by use of a geometrical ray trace optical code, and an experimental AOTF system was analyzed. Considerable improvement in the potential spatial resolution is predicted with confocal optics, which could accommodate large pixel-limited image fields of greater than 10(6) pixels. When the image quality of the experimental system was assessed, the resolution was found to be improved by the confocal optics and was diffraction limited. Higher resolution could have been obtained with the use of larger optics to increase the throughput before being limited by the aberrations.
Feng, J.; Padmore, H.; Wei, D. H.; Anders, S.; Wu, Y.; Scholl, A.; Robin, D.
2002-03-01
The modeling of the optical properties of the acceleration field and objective lens of a photoemission electron microscope (PEEM) is presented. Theory to calculate the aberrations of the extraction field was derived, and extended to include relativistic effects. An analysis of the microscope's electron optical performance and aberrations has been performed using an analytical model as well as a ray tracing method. Ray tracing has the flexibility needed for the assessment of aberrations where the geometry is too complex for analytical methods. This work shows that in the case of a simple PEEM front end of the acceleration gap and objective lens, the all orders ray tracing and full analytical treatments agree to very high precision. This allows us now to use the ray tracing method in situations where analytical methods are difficult, such as an aberration compensating electron mirror.
Hansen, Thomas Willum; Wagner, Jakob Birkedal; Dunin-Borkowski, Rafal E.
2010-01-01
The latest generation of environmental transmission electron microscopes incorporates aberration correctors and monochromators, allowing studies of chemical reactions and growth processes with improved spatial resolution and spectral sensitivity. Here, we describe the performance of such an instr......The latest generation of environmental transmission electron microscopes incorporates aberration correctors and monochromators, allowing studies of chemical reactions and growth processes with improved spatial resolution and spectral sensitivity. Here, we describe the performance...
S. Sridhar
2012-01-01
Full Text Available Problem statement: The spiraling growth of IT industry has witnessed an unprecedented change in the software development paradigm, from algorithmic models to machine learning techniques. At present, there are no standard methods to predict the accuracy of software cost estimation, which is an important goal of the software community. Approach: This study proposes a simple and systematic algorithmic procedure for analogy based software cost prediction to detect the aberrant data points. The algorithm is analyzed and correlated with the Desharnais and NASA datasets containing all adaptive features with numerical and categorical variables. Results: The interpreted curves using the above datasets depict a discernible anomaly for the dataset having more categorical variables, thereby indicating the erroneous data points. Conclusion: The elimination of aberrant data points using the new algorithmic method improves the accuracy of software cost estimation using historical data sets.
Sergio Vázquez-Montiel
2010-01-01
Full Text Available We propose an alternative method to design diffractive lenses free of spherical aberration for monochromatic light. Our method allows us to design diffractive lenses with the diffraction structure recorded on the last surface; this surface can be flat or curved with rotation symmetry. The equations that we propose calculate the diffraction profiles for any substratum, for any f-number, and for any position of the object. We use the lens phase coefficients to compensate the spherical aberration. To calculate these coefficients, we use an analytic-numerical method. The calculations are exact, and the optimization process is not required.
Algorithm for correcting optimization convergence errors in Eclipse.
Zacarias, Albert S; Mills, Michael D
2009-10-14
IMRT plans generated in Eclipse use a fast algorithm to evaluate dose for optimization and a more accurate algorithm for a final dose calculation, the Analytical Anisotropic Algorithm. The use of a fast optimization algorithm introduces optimization convergence errors into an IMRT plan. Eclipse has a feature where optimization may be performed on top of an existing base plan. This feature allows for the possibility of arriving at a recursive solution to optimization that relies on the accuracy of the final dose calculation algorithm and not the optimizer algorithm. When an IMRT plan is used as a base plan for a second optimization, the second optimization can compensate for heterogeneity and modulator errors in the original base plan. Plans with the same field arrangement as the initial base plan may be added together by adding the initial plan optimal fluence to the dose correcting plan optimal fluence.A simple procedure to correct for optimization errors is presented that may be implemented in the Eclipse treatment planning system, along with an Excel spreadsheet to add optimized fluence maps together.
A string correction algorithm for cursive script recognition.
Bozinovic, R; Srihari, S N
1982-06-01
This paper deals with a method of estimating a correct string X from its noisy version Y produced by a cursive script recognition system. An accurate channel model that allows for splitting, merging, and substitution of symbols is introduced. The best estimate X is obtained by using a dynamic programming search which combines a known search strategy (stack decoding) with a trie structure representation of a dictionary. The computational complexity of the algorithm is derived and compared with that of a method based on the generalized Levenshtein metric. Experimental results with the algorithm on English text based on a dictionary of the 1027 most commonly occurring words are described.
A Corrective Training Algorithm for Adaptive Learning in Bag Generation
Chen, H H; Chen, Hsin-Hsi; Lee, Yue-Shi
1994-01-01
The sampling problem in training corpus is one of the major sources of errors in corpus-based applications. This paper proposes a corrective training algorithm to best-fit the run-time context domain in the application of bag generation. It shows which objects to be adjusted and how to adjust their probabilities. The resulting techniques are greatly simplified and the experimental results demonstrate the promising effects of the training algorithm from generic domain to specific domain. In general, these techniques can be easily extended to various language models and corpus-based applications.
Lotnyk, Andriy, E-mail: andriy.lotnyk@iom-leipzig.de; Poppitz, David; Gerlach, Jürgen W.; Rauschenbach, Bernd [Leibniz Institute of Surface Modification, Permoserstr. 15, D-04318 Leipzig (Germany)
2014-02-17
In this report, we show that an annular dark-field detector in an aberration-corrected scanning transmission electron microscope allows the direct observation of light element columns in crystalline lattices. At specific imaging conditions, an enhancement of the intensities of light element columns in the presence of heavy element columns is observed. Experimental results are presented for imaging the nitrogen and carbon atomic columns at the GaN-SiC interface and within the GaN and SiC compounds. The crystal polarity of GaN at the interface is identified. The obtained findings are discussed and are well supported by image simulations.
Wang, Hongtao
2012-01-01
Interaction between single noble metal atoms and graphene edges has been investigated via aberration-corrected and monochromated transmission electron microscopy. A collective motion of the Au atom and the nearby carbon atoms is observed in transition between energy-favorable configurations. Most trapping and detrapping processes are assisted by the dangling carbon atoms, which are more susceptible to knock-on displacements by electron irradiation. Thermal energy is lower than the activation barriers in transition among different energy-favorable configurations, which suggests electron-beam irradiation can be an efficient way of engineering the graphene edge with metal atoms. © 2012 The Royal Society of Chemistry.
A new nonuniformity correction algorithm for infrared line scanners
Sui, Jing; Jin, Wei-qi; Dong, Li-quan; Wang, Xia
2006-05-01
Nonuniformity correction (NUC) is a critical task for achieving higher performances in modern infrared imaging systems. The striping fixed pattern noise produced by the scanning-type infrared imaging system can hardly be removed clearly by many scene-based non-uniformity correction methods, which can work effectively for staring focal plane arrays (FPA). We proposed an improved nonuniformity algorithm that corrects the aggregate nonuniformity by two steps for the infrared line scanners (IRLS). The novel contribution in our approach is the integration of local constant statistics (LCS) constraint and neural networks. First, the nonuniformity due to the readout electronics is corrected by treating every row of pixels as one channel and normalizing the channel outputs so that each channel produces pixels with the same mean and standard deviation as median value of the local channels statistics. Second, for IRLS every row is generated by pushbrooming one detector on line sensors, we presume each detector has one neuron with a weight and an offset as correction parameters, which can update column by column recursively at Least Mean Square sense. A one-dimensional median filter is used to produce ideal output of linear neural network and some optimization strategies are added to increase the robustness of learning process. Applications to both simulated and real infrared images demonstrated that this algorithm is self-adaptive and able to complete NUC by only one frames. If the nonuniformity is not so severe then only the first step can obtain a good correction result. Combination of two steps can achieve a higher correction level and remove stripe pattern noise clearly.
Gamm, B; Schultheiss, K; Gerthsen, D; Schröder, R R
2008-08-01
In this theoretical study we analyze contrast transfer of weak-phase objects in a transmission electron microscope, which is equipped with an aberration corrector (C(s)-corrector) in the imaging lens system and a physical phase plate in the back focal plane of the objective lens. For a phase shift of pi/2 between scattered and unscattered electrons induced by a physical phase plate, the sine-type phase contrast transfer function is converted into a cosine-type function. Optimal imaging conditions could theoretically be achieved if the phase shifts caused by the objective lens defocus and lens aberrations would be equal to zero. In reality this situation is difficult to realize because of residual aberrations and varying, non-zero local defocus values, which in general result from an uneven sample surface topography. We explore the conditions--i.e. range of C(s)-values and defocus--for most favourable contrast transfer as a function of the information limit, which is only limited by the effect of partial coherence of the electron wave in C(s)-corrected transmission electron microscopes. Under high-resolution operation conditions we find that a physical phase plate improves strongly low- and medium-resolution object contrast, while improving tolerance to defocus and C(s)-variations, compared to a microscope without a phase plate.
Background Simulation and Correction Algorithm in Spot Weld Image Processing
无
2001-01-01
One of the chief works for inspecting spot weld quality by X-ray to obtain an ideal and uniform digital image. This paper introduces three methods of image background simulation algorithm, and the effect of background correction was compared. It may be safely said that Kalman filter method is simple and fast for general image; the FFT method has a good adaptability for background simulation.
Orbit correction algorithm for SSRF fast orbit feedback system
LIU Ming; YIN Chongxian; LIU Dekang
2009-01-01
A fast orbit feedback system is designed at SSRF to suppress beam orbit disturbance within sub-micron in the bandwidth up to 100 Hz.The SVD (Singular value decomposition) algorithm is applied to calculate the inverse response matrix in global orbit correction.The number of singular eigenvalues will influence orbit noise suppression and corrector strengths.The method to choose singular eigenvalue rejection threshold is studied in this paper,and the simulation and experiment results are also presented.
刘伟伟; 任煜轩; 高红芳; 孙晴; 王自强; 李银妹
2012-01-01
像差会影响光镊对粒子的捕获效果．全息阵列光镊中，像差不仅来自光学元件，由特定算法设计的光阱相位片也会在光路中引入像差．本文通过液晶空间光调制器加载泽尼克多项式相位图，对全息阵列光镊中由光栅透镜组型算法引起的像差进行校正．结果显示：利用三阶泽尼克多项式可有效消除光路中由光栅透镜组型算法引起的慧差，使得捕获2“m聚苯乙烯小球的阵列光阱刚度提高了约40％；对比不同项的像差校正结果发现，全息阵列光镊中由算法引起的慧差与光学元件引起的像差一样，也会对阵列光阱的捕获效果产生较大影响；同时根据一阶像差校正结果可得光栅透镜组型算法对于一阶泽尼克像差具有鲁棒性．实验结果表明，对全息阵列光镊中由算法引起的像差进行校正，对于提高光阱的捕获效果和深化对算法特性的认识都具有重要意义．%Aberrations will degrade trapping performance of optical tweezers. In the holographic optical tweezers, aberrations originate not only from optical elements but also from holographic phase hologram of optical traps designed by a certain algorithna. We utilize a spatial light modulator to imprint Zernike polynomials phase hologram for correcting some certain aberrations in holographic array optical tweezers which are caused by grating and lens algorithm. The results show that thirdorder Zernike term can effectively correct coma due to the algorithm in the optical train, and the trap stiffness for 2 tm microns diameter polystyrene beads can reach 40%. Further comparison between different Zernike term aberration correction effects demonstrates that coma caused by grating and lens algorithm in the holographic array optical tweezer has the same serious influence on tweezer trapping performance as the aberrations originating from optical elements. Meanwhile, based on firstorder Zernike term
Correcting lateral chromatic aberrations in non-monochromatic X-ray microscopy
Falch, Ken Vidar; Detlefs, Carsten; Di Michiel, Marco; Snigireva, Irina; Snigirev, Anatoly; Mathiesen, Ragnvald H.
2016-08-01
Lateral chromatic aberration in microscopy based on refractive optics may be reduced significantly by adjustments to the illumination scheme. By taking advantage of a broadened bandwidth illumination, the proposed scheme could open for x-ray microscopy with spatial resolution in the range 150-200 nm at millisecond frame rates. The scheme is readily implemented and is achievable using only standard refractive x-ray lenses, which has the advantage of high efficiency. It also maximizes the transmission and removes the spatial filtering effects associated with absorption in x-ray lenses.
Flux-corrected transport principles, algorithms, and applications
Kuzmin, Dmitri; Turek, Stefan
2005-01-01
Addressing students and researchers as well as CFD practitioners, this book describes the state of the art in the development of high-resolution schemes based on the Flux-Corrected Transport (FCT) paradigm. Intended for readers who have a solid background in Computational Fluid Dynamics, the book begins with historical notes by J.P. Boris and D.L. Book. Review articles that follow describe recent advances in the design of FCT algorithms as well as various algorithmic aspects. The topics addressed in the book and its main highlights include: the derivation and analysis of classical FCT schemes with special emphasis on the underlying physical and mathematical constraints; flux limiting for hyperbolic systems; generalization of FCT to implicit time-stepping and finite element discretizations on unstructured meshes and its role as a subgrid scale model for Monotonically Integrated Large Eddy Simulation (MILES) of turbulent flows. The proposed enhancements of the FCT methodology also comprise the prelimiting and '...
Multirobot FastSLAM Algorithm Based on Landmark Consistency Correction
Shi-Ming Chen
2014-01-01
Full Text Available Considering the influence of uncertain map information on multirobot SLAM problem, a multirobot FastSLAM algorithm based on landmark consistency correction is proposed. Firstly, electromagnetism-like mechanism is introduced to the resampling procedure in single-robot FastSLAM, where we assume that each sampling particle is looked at as a charged electron and attraction-repulsion mechanism in electromagnetism field is used to simulate interactive force between the particles to improve the distribution of particles. Secondly, when multiple robots observe the same landmarks, every robot is regarded as one node and Kalman-Consensus Filter is proposed to update landmark information, which further improves the accuracy of localization and mapping. Finally, the simulation results show that the algorithm is suitable and effective.
Baudoin, Jean-Pierre; Jinschek, Joerg R; Boothroyd, Chris B; Dunin-Borkowski, Rafal E; de Jonge, Niels
2013-08-01
Transmission electron microscopy (TEM) in combination with electron tomography is widely used to obtain nanometer scale three-dimensional (3D) structural information about biological samples. However, studies of whole eukaryotic cells are limited in resolution and/or contrast on account of the effect of chromatic aberration of the TEM objective lens on electrons that have been scattered inelastically in the specimen. As a result, 3D information is usually obtained from sections and not from whole cells. Here, we use chromatic aberration-corrected TEM to record bright-field TEM images of nanoparticles in a whole mount macrophage cell. Tilt series of images are used to generate electron tomograms, which are analyzed to assess the spatial resolution that can be achieved for different vertical positions in the specimen. The uptake of gold nanoparticles coated with low-density lipoprotein (LDL) is studied. The LDL is found to assemble in clusters. The clusters contain nanoparticles taken up on different days, which are joined without mixing their nanoparticle cargo.
Wong, Alexander; Jin, Chao; Wang, Xiao Yu
2015-01-01
Lensfree on-chip microscopy is an emerging imaging technique that can be used to visualize and study biological specimens without the need for imaging lens systems. Important issues that can limit the performance of lensfree on-chip microscopy include interferometric aberrations, acquisition noise, and image reconstruction artifacts. In this study, we introduce a Bayesian-based method for performing aberration correction and numerical diffraction that accounts for all three of these issues to improve the effective numerical aperture (NA) and signal-to-noise ratio (SNR) of the reconstructed microscopic image. The proposed method was experimentally validated using the USAF resolution target as well as real waterborne Anabaena flos-aquae samples, demonstrating improvements in NA by ~25% over the standard method, and improvements in SNR of 2.3 dB and 3.8 dB in the reconstructed image when compared to the reconstructed images produced using the standard method and a maximum likelihood estimation method, respective...
Krause, F F; Rosenauer, A; Barthel, J; Mayer, J; Urban, K; Dunin-Borkowski, R E; Brown, H G; Forbes, B D; Allen, L J
2017-10-01
This paper addresses a novel approach to atomic resolution elemental mapping, demonstrating a method that produces elemental maps with a similar resolution to the established method of electron energy-loss spectroscopy in scanning transmission electron microscopy. Dubbed energy-filtered imaging scanning transmission electron microscopy (EFISTEM) this mode of imaging is, by the quantum mechanical principle of reciprocity, equivalent to tilting the probe in energy-filtered transmission electron microscopy (EFTEM) through a cone and incoherently averaging the results. In this paper we present a proof-of-principle EFISTEM experimental study on strontium titanate. The present approach, made possible by chromatic aberration correction, has the advantage that it provides elemental maps which are immune to spatial incoherence in the electron source, coherent aberrations in the probe-forming lens and probe jitter. The veracity of the experiment is supported by quantum mechanical image simulations, which provide an insight into the image-forming process. Elemental maps obtained in EFTEM suffer from the effect known as preservation of elastic contrast, which, for example, can lead to a given atomic species appearing to be in atomic columns where it is not to be found. EFISTEM very substantially reduces the preservation of elastic contrast and yields images which show stability of contrast with changing thickness. The experimental application is demonstrated in a proof-of-principle study on strontium titanate. Copyright © 2017 Elsevier B.V. All rights reserved.
Letter: A method for the chromatic aberration correction of a laser time of-flight mass analyzer.
Sysoeva, Elizaveta A; Sysoev, Alexander A
2016-01-01
The new ion-optical system of the laser time-of-flight (TOF) mass spectrometer on the basis of two tandem wedge-shape reflectors has been offered and implemented. A new method of correcting chromatic aberration by the ion energy was proposed that used a wire electrode unit with adjustable potentials. This unit allows one to adjust the local TOF of the ions in a narrow energy range ± (1-2)% within the total ion packet with an energy spread of ± 20%. The method reduces the duration of the ion packets by up to 1.5ns, which enables us to obtain the restriction of resolution at a level not worse than R ~ 10500 for a TOF ~35 µs. The aim of the project is to increase the separation of isobaric ions to improve the limit of detection of the laser TOF-MS for the analysis of high-purity samples.
Jin, Lei; Barthel, Juri; Jia, Chun-Lin; Urban, Knut W
2017-01-31
The application of combined chromatic and spherical aberration correction in high-resolution transmission electron microscopy enables a significant improvement of the spatial resolution down to 50 pm. We demonstrate that such a resolution can be achieved in practice at 200kV. Diffractograms of images of gold nanoparticles on amorphous carbon demonstrate corresponding information transfer. The Y atom pairs in [010] oriented yttrium orthoaluminate are successfully imaged together with the Al and the O atoms. Although the 57 pm pair separation is well demonstrated separations between 55 pm and 80 pm are measured. This observation is tentatively attributed to structural relaxations and surface reconstruction in the very thin samples used. Quantification of the resolution limiting effective image spread is achieved based on an absolute match between experimental and simulated image intensity distributions.
Sánchez-Santolino, G. [GFMC, Departamento. Física Aplicada III, Universidad Complutense de Madrid, 28040 Madrid (Spain); Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6071 (United States); Tornos, J.; Bruno, F.Y.; Cuellar, F.A.; Leon, C.; Santamaría, J. [GFMC, Departamento. Física Aplicada III, Universidad Complutense de Madrid, 28040 Madrid (Spain); Pennycook, S.J [Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6071 (United States); Varela, M., E-mail: mvarela@ornl.gov [Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6071 (United States); GFMC, Departamento. Física Aplicada III, Universidad Complutense de Madrid, 28040 Madrid (Spain)
2013-04-15
An unusual conducting surface state can be produced in SrTiO{sub 3} substrates by irradiation with Argon ions from a plasma source, at low energy and high doses. The effects of irradiation are analyzed here by atomic force microscopy (AFM) and aberration corrected scanning transmission electron microscopy (STEM) combined with electron energy loss spectroscopy (EELS). Depth sensitive studies demonstrate the existence of a heavily damaged surface layer and an oxygen vacancy rich layer immediately underneath, both induced during the irradiation process. We find a clear dependence of the Ti oxidation state with the depth, with a very intense Ti{sup 3+} component near the surface. Oxygen vacancies act as n-type doping by releasing electrons into the lattice and producing an insulator-to-metal transition, which explains the unusual metallic behavior of these samples.
Sinclair, Robert; Kempen, Paul Joseph; Chin, Richard; Koh, Ai Leen
2014-05-01
This article describes the establishment, over a period of ten years or so, of a multi-user, institution-wide facility for the characterization of materials and devices at the nano-scale. Emphasis is placed on the type of equipment that we have found to be most useful for our users, and the business strategy that maintains its operations. A central component of our facility is an aberration-corrected environmental transmission electron microscope and its application is summarized in the studies of plasmon energies of silver nanoparticles, the band gap of PbS quantum dots, atomic site occupancy near grain boundaries in yttria stabilized zirconia, the lithiation of silicon nanoparticles, in situ observations on carbon nanotube oxidation and the electron tomography of varicella zoster virus nucleocapsids.
Sinclair, Robert; Kempen, Paul Joseph; Chin, Richard; Koh, Ai Leen
2014-01-01
This article describes the establishment, over a period of ten years or so, of a multi-user, institution-wide facility for the characterization of materials and devices at the nano-scale. Emphasis is placed on the type of equipment that we have found to be most useful for our users, and the business strategy that maintains its operations. A central component of our facility is an aberration-corrected environmental transmission electron microscope and its application is summarized in the studies of plasmon energies of silver nanoparticles, the band gap of PbS quantum dots, atomic site occupancy near grain boundaries in yttria stabilized zirconia, the lithiation of silicon nanoparticles, in situ observations on carbon nanotube oxidation and the electron tomography of varicella zoster virus nucleocapsids. PMID:25364299
Matsuda, Junko; Yoshida, Kenta; Sasaki, Yukichi; Uchiyama, Naoki; Akiba, Etsuo
2014-08-01
In situ transmission electron microscopy (TEM) was performed to observe the hydrogenation of Mg-Ni films in a hydrogen atmosphere of 80-100 Pa. An aberration-corrected environmental TEM with a differential pumping system allows us to reveal the Angstrom-scale structure of the films in the initial stage of hydrogenation: first, nucleation and growth of Mg2NiH4 crystals with a lattice spacing of 0.22 nm in an Mg-rich amorphous matrix of the film occurs within 20 s after the start of the high-resolution observation, then crystallization of MgH2 with a smaller spacing of 0.15 nm happens after approximately 1 min. Our in situ TEM method is also applicable to the analysis of other hydrogen-related materials.
Quantum Error Correction Protects Quantum Search Algorithms Against Decoherence.
Botsinis, Panagiotis; Babar, Zunaira; Alanis, Dimitrios; Chandra, Daryus; Nguyen, Hung; Ng, Soon Xin; Hanzo, Lajos
2016-12-07
When quantum computing becomes a wide-spread commercial reality, Quantum Search Algorithms (QSA) and especially Grover's QSA will inevitably be one of their main applications, constituting their cornerstone. Most of the literature assumes that the quantum circuits are free from decoherence. Practically, decoherence will remain unavoidable as is the Gaussian noise of classic circuits imposed by the Brownian motion of electrons, hence it may have to be mitigated. In this contribution, we investigate the effect of quantum noise on the performance of QSAs, in terms of their success probability as a function of the database size to be searched, when decoherence is modelled by depolarizing channels' deleterious effects imposed on the quantum gates. Moreover, we employ quantum error correction codes for limiting the effects of quantum noise and for correcting quantum flips. More specifically, we demonstrate that, when we search for a single solution in a database having 4096 entries using Grover's QSA at an aggressive depolarizing probability of 10(-3), the success probability of the search is 0.22 when no quantum coding is used, which is improved to 0.96 when Steane's quantum error correction code is employed. Finally, apart from Steane's code, the employment of Quantum Bose-Chaudhuri-Hocquenghem (QBCH) codes is also considered.
Quantum Error Correction Protects Quantum Search Algorithms Against Decoherence
Botsinis, Panagiotis; Babar, Zunaira; Alanis, Dimitrios; Chandra, Daryus; Nguyen, Hung; Ng, Soon Xin; Hanzo, Lajos
2016-12-01
When quantum computing becomes a wide-spread commercial reality, Quantum Search Algorithms (QSA) and especially Grover’s QSA will inevitably be one of their main applications, constituting their cornerstone. Most of the literature assumes that the quantum circuits are free from decoherence. Practically, decoherence will remain unavoidable as is the Gaussian noise of classic circuits imposed by the Brownian motion of electrons, hence it may have to be mitigated. In this contribution, we investigate the effect of quantum noise on the performance of QSAs, in terms of their success probability as a function of the database size to be searched, when decoherence is modelled by depolarizing channels’ deleterious effects imposed on the quantum gates. Moreover, we employ quantum error correction codes for limiting the effects of quantum noise and for correcting quantum flips. More specifically, we demonstrate that, when we search for a single solution in a database having 4096 entries using Grover’s QSA at an aggressive depolarizing probability of 10-3, the success probability of the search is 0.22 when no quantum coding is used, which is improved to 0.96 when Steane’s quantum error correction code is employed. Finally, apart from Steane’s code, the employment of Quantum Bose-Chaudhuri-Hocquenghem (QBCH) codes is also considered.
Mahalingam, Krishnamurthy; Haugan, Heather J; Brown, Gail J; Eyink, Kurt G
2013-04-01
The strain distribution across interfaces in InAs/GaSb superlattices grown on (100)-GaSb substrates is investigated by aberration corrected transmission electron microscopy. Atomic resolution images of interfaces were obtained by conventional high resolution transmission electron microscopy (HRTEM), using the negative spherical-aberration imaging mode, and by scanning transmission electron microscopy (STEM), using the high-angle annular dark-field (HAADF) imaging mode. The local atomic displacements across interfaces were determined from these images using the peak pair algorithm, from which strain maps were calculated with respect to a reference lattice extracted from the GaSb substrate region. Both techniques yield consistent results, which reveal that the InAs-on-GaSb interface is nearly strain balanced, whereas the GaSb-on-InAs interface is in tensile strain, indicating that the prevalent bond type at this interface is Ga-As. In addition, the GaSb layers in the superlattice are compressively strained indicating the incorporation of In into these layers. Further analysis of the HAADF-STEM images indicates an estimated 4% In content in the GaSb layers and that the GaSb-on-InAs interface contributes to about 27% of the overall superlattice strain. The strain measurements in the InAs layers are in good agreement with the theoretical values determined from elastic constants. Furthermore, the overall superlattice strain determined from this analysis is also in good agreement with the measurements determined by high-resolution X-ray diffraction.
Aberration-corrected scanning transmission electron microscopy for complex transition metal oxides
Qing-Hua, Zhang; Dong-Dong, Xiao; Lin, Gu
2016-06-01
Lattice, charge, orbital, and spin are the four fundamental degrees of freedom in condensed matter, of which the interactive coupling derives tremendous novel physical phenomena, such as high-temperature superconductivity (high-T c SC) and colossal magnetoresistance (CMR) in strongly correlated electronic system. Direct experimental observation of these freedoms is essential to understanding the structure-property relationship and the physics behind it, and also indispensable for designing new materials and devices. Scanning transmission electron microscopy (STEM) integrating multiple techniques of structure imaging and spectrum analysis, is a comprehensive platform for providing structural, chemical and electronic information of materials with a high spatial resolution. Benefiting from the development of aberration correctors, STEM has taken a big breakthrough towards sub-angstrom resolution in last decade and always steps forward to improve the capability of material characterization; many improvements have been achieved in recent years, thereby giving an in-depth insight into material research. Here, we present a brief review of the recent advances of STEM by some representative examples of perovskite transition metal oxides; atomic-scale mapping of ferroelectric polarization, octahedral distortions and rotations, valence state, coordination and spin ordering are presented. We expect that this brief introduction about the current capability of STEM could facilitate the understanding of the relationship between functional properties and these fundamental degrees of freedom in complex oxides. Project supported by the National Key Basic Research Project, China (Grant No. 2014CB921002), the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No. XDB07030200), and the National Natural Science Foundation of China (Grant Nos. 51522212 and 51421002).
Holographic Properties of BR-D96N Film and Its Application in Hologram Aberration Correction
ZHENG Yuan(郑媛); YAO Bao-Li(姚保利); WANG Ying-Li(王英利); MENKE Neimule(门克内木乐); LEI Ming(雷铭); CHEN Guo-Fu(陈国夫); Norbert HAMPP
2003-01-01
A biophotochromic material, i.e., genetic mutant bacteriorhodopsin (BR-D96N), was experimentally studied on its holographic recording properties. The saturation absorption curve and the diffraction efficiency curve were measured respectively. As holographic storage application, reflection type polarization holograms were recorded on the BR-D96N film. The 173° configuration between the object and reference beams proves that the spatial resolution of the film is over 6000 lines/mm. By using phase conjugate wave of reference beam as reconstruction beam, the distorted object image introduced by the optical components and the defects in the recording medium can be well corrected.
Kisielowski, C; Freitag, B; Bischoff, M; van Lin, H; Lazar, S; Knippels, G; Tiemeijer, P; van der Stam, M; von Harrach, S; Stekelenburg, M; Haider, M; Uhlemann, S; Müller, H; Hartel, P; Kabius, B; Miller, D; Petrov, I; Olson, E A; Donchev, T; Kenik, E A; Lupini, A R; Bentley, J; Pennycook, S J; Anderson, I M; Minor, A M; Schmid, A K; Duden, T; Radmilovic, V; Ramasse, Q M; Watanabe, M; Erni, R; Stach, E A; Denes, P; Dahmen, U
2008-10-01
The ability of electron microscopes to analyze all the atoms in individual nanostructures is limited by lens aberrations. However, recent advances in aberration-correcting electron optics have led to greatly enhanced instrument performance and new techniques of electron microscopy. The development of an ultrastable electron microscope with aberration-correcting optics and a monochromated high-brightness source has significantly improved instrument resolution and contrast. In the present work, we report information transfer beyond 50 pm and show images of single gold atoms with a signal-to-noise ratio as large as 10. The instrument's new capabilities were exploited to detect a buried Sigma3 {112} grain boundary and observe the dynamic arrangements of single atoms and atom pairs with sub-angstrom resolution. These results mark an important step toward meeting the challenge of determining the three-dimensional atomic-scale structure of nanomaterials.
Hansen, Anja; Géneaux, Romain; Günther, Axel; Krüger, Alexander; Ripken, Tammo
2013-06-01
In femtosecond laser ophthalmic surgery tissue dissection is achieved by photodisruption based on laser induced optical breakdown. In order to minimize collateral damage to the eye laser surgery systems should be optimized towards the lowest possible energy threshold for photodisruption. However, optical aberrations of the eye and the laser system distort the irradiance distribution from an ideal profile which causes a rise in breakdown threshold energy even if great care is taken to minimize the aberrations of the system during design and alignment. In this study we used a water chamber with an achromatic focusing lens and a scattering sample as eye model and determined breakdown threshold in single pulse plasma transmission loss measurements. Due to aberrations, the precise lower limit for breakdown threshold irradiance in water is still unknown. Here we show that the threshold energy can be substantially reduced when using adaptive optics to improve the irradiance distribution by spatial beam shaping. We found that for initial aberrations with a root-mean-square wave front error of only one third of the wavelength the threshold energy can still be reduced by a factor of three if the aberrations are corrected to the diffraction limit by adaptive optics. The transmitted pulse energy is reduced by 17% at twice the threshold. Furthermore, the gas bubble motions after breakdown for pulse trains at 5 kilohertz repetition rate show a more transverse direction in the corrected case compared to the more spherical distribution without correction. Our results demonstrate how both applied and transmitted pulse energy could be reduced during ophthalmic surgery when correcting for aberrations. As a consequence, the risk of retinal damage by transmitted energy and the extent of collateral damage to the focal volume could be minimized accordingly when using adaptive optics in fs-laser surgery.
Urban, K W; Rose, H
2016-02-01
We comment on a Short Communication recently published in Ultramicroscopy in which Brown et al. criticize our description of the time sequence of events in the development of aberration correction systems in electron optics during the 1990s put forward in the introduction to the Ultramicroscopy April 2015 Special Issue. We present an analysis of the published literature furnishing evidence that our description is correct.
Canopy induced aberration correction in airborne electro-optical imaging systems
Harder, James A.; Sprague, Michaelene W.
2011-11-01
An increasing number of electro-optical systems are being used by pilots in tactical aircraft. This means that the afore mentioned systems must operate through the aircrafts canopy, unfortunately the canopy functions as a less than ideal lens element in the electro-optical sensor optical path. The canopy serves first and foremost as an aircraft structural component, considerations like minimizing the drag co-efficient and the ability to survive bird strikes take precedence over achieving optimal optical characteristics. This paper describes how the authors characterized the optical characteristics of an aircraft canopy. Families of modulation transfer functions were generated, for various viewing geometries through the canopy and for various electro-optical system entrance pupil diameters. These functions provided us with the means to significantly reduce the effect of the canopy "lens" on the performance of a representative electro-optical system, using an Astigmatic Corrector Lens. A comparison of the electro-optical system performance with and without correction is also presented.
Nagai, Takuro, E-mail: nagai.takuro@nims.go.jp [National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044 (Japan); Haruta, Mitsutaka [National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044 (Japan); Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 (Japan); Kikuchi, Masashi [Sumitomo Electric Industries Ltd., Konohana-ku, Osaka 554-0024 (Japan); Zhang, Weizhu; Takeguchi, Masaki; Kimoto, Koji [National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044 (Japan)
2014-05-15
Highlights: • We investigate a Ag-sheathed Bi-2223 wire by low-voltage aberration-corrected STEM. • Atomic displacements enable each layer to be continuous at edge grain boundaries. • The grains are terminated with deficient (Bi,Pb)–O layers at the other boundaries. • EELS mapping visualizes atomic columns in the intergrowth of Bi-2212 and 2234 phases. • HAADF analysis shows modulation of the occupancy of the (Bi,Pb) sites along [1 1 0]. - Abstract: Aberration correction in scanning transmission electron microscopy (STEM) enables an atomic-scale probe size of ∼0.1 nm at a low accelerating voltage of 80 kV that avoids knock-on damage in materials including light elements such as oxygen. We used this advanced method of microscopy to directly observe atomic columns in a (Bi,Pb){sub 2}Sr{sub 2}Ca{sub 2}Cu{sub 3}O{sub 10+δ} (Bi-2223) superconducting wire produced by a powder-in-tube method. Using the atomic-number (Z) contrast mechanism, incoherent high-angle annular dark-field (HAADF) imaging clearly showed the atomic columns. Atomic displacements toward the boundary with a maximum magnitude of ∼0.26 nm enable each atomic layer to be continuous at edge grain boundaries (EGBs). The grains tend to be terminated with deficient (Bi,Pb)–O single layers at c-axis twist boundaries (TWBs) and small-angle asymmetrical tilt boundaries (ATBs); a quantitative HAADF analysis showed that the occupancies of the (Bi,Pb) sites around these boundaries are ∼0.66 and ∼0.72, respectively. Electron energy-loss spectroscopy (EELS) mapping successfully visualized atomic columns in the half-unit cell intergrowth of (Bi,Pb){sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+δ} (Bi-2212) and (Bi,Pb){sub 2}Sr{sub 2}Ca{sub 3}Cu{sub 4}O{sub 12+δ} (Bi-2234) phases. Furthermore, the HAADF analysis indicated that the occupancy of the (Bi,Pb) sites is modulated between ∼0.88 and 1.0 along the diagonal direction of the primitive perovskite cell with the same period as the structural modulation.
Andréia Peltier Urbano
2009-10-01
Full Text Available OBJETIVO: Comparar a correção das aberrações oculares nos retratamentos de LASIK personalizado e convencional. MÉTODOS: Foi realizado um estudo prospectivo, randomizado, de 74 olhos de 37 pacientes submetidos ao retratamento de LASIK para correção de miopia e astigmatismo. Cada paciente foi submetido ao retratamento de LASIK personalizado Zyoptix (Bausch & Lomb em um olho e convencional Planoscan (Bausch & Lomb no olho contralateral. Foi comparada a correção das aberrações oculares nos retratamentos personalizado e convencional. RESULTADOS: No sexto mês pós-operatório, os olhos submetidos ao retratamento Zyoptix apresentaram diminuição estatisticamente significativa do defocus, astigmatismo, coma, aberração esférica, segunda ordem, terceira ordem, alta ordem e aberrações totais. Os olhos submetidos ao retratamento Planoscan apresentaram diminuição estatisticamente significativa do defocus, segunda ordem e aberrações totais. CONCLUSÕES: O retratamento personalizado foi superior ao retratamento convencional para a correção das aberrações oculares de baixa e alta ordens.PURPOSE: To compare the correction of ocular aberrations between custom and standard LASIK retreatment. METHODS: Prospective, randomized trial with paired eye control of 74 eyes from 37 patients who underwent LASIK retreatment. Each patient underwent retreatment using Zyoptix LASIK (Bausch & Lomb in 1 eye and Planoscan LASIK (Bausch & Lomb in the fellow eye. Correction of ocular aberrations was compared between custom and standard LASIK retreatments. RESULTS: At 6 months, there was a statistically significant reduction in defocus, astigmatism, coma, spherical aberration, second, third, higher-order and total aberration in Zyoptix eyes. There was a statistically significant reduction in defocus, second-order and total aberration in Planoscan eyes. CONCLUSIONS: Custom retreatment was statistically superior than standard retreatment for correction of lower
Abraham, Thomas; Allan, Sarah E; Levings, Megan K
2010-08-01
with DNA molecules. In conclusion, our studies clearly demonstrate the importance of PSF measurements, chromatic aberration corrections followed by deconvolution in the accurate determination of transcription factors in the 3D cellular space. The reported imaging and processing methods can be a practical guide for quantitative fluorescence imaging of similar cellular systems and can provide a basis for further development.
Yubiao Niu
2016-12-01
Full Text Available Molybdenum disulphide (MoS2 is an earth-abundant material which has several industrial applications and is considered a candidate for platinum replacement in electrochemistry. Size-selected MoS2 nanoclusters were synthesised in the gas phase using a magnetron sputtering, gas condensation cluster beam source with a lateral time-of-flight mass selector. Most of the deposited MoS2 nanoclusters, analysed by an aberration-corrected scanning transmission electron microscope (STEM in high-angle annular dark field (HAADF mode, showed poorly ordered layer structures with an average diameter of 5.5 nm. By annealing and the addition of sulphur to the clusters (by sublimation in the cluster source, the clusters were transformed into larger, crystalline structures. Annealing alone did not lead to crystallization, only to a cluster size increase by decomposition and coalescence of the primary clusters. Sulphur addition alone led to a partially crystalline structure without a significant change in the size. Thus, both annealing and sulphur addition processes were needed to obtain highly crystalline MoS2 nanoclusters.
Sales, D L; Varela, M; Pennycook, S J; Galindo, P L; González, L; González, Y; Fuster, D; Molina, S I
2010-08-13
Evolution of the size, shape and composition of self-assembled InAs/InP quantum wires through the Stranski-Krastanov transition has been determined by aberration-corrected Z-contrast imaging. High resolution compositional maps of the wires in the initial, intermediate and final formation stages are presented. (001) is the main facet at their very initial stage of formation, which is gradually reduced in favour of [114] or [118], ending with the formation of mature quantum wires with {114} facets. Significant changes in wire dimensions are measured when varying slightly the amount of InAs deposited. These results are used as input parameters to build three-dimensional models that allow calculation of the strain energy during the quantum wire formation process. The observed morphological evolution is explained in terms of the calculated elastic energy changes at the growth front. Regions of the wetting layer close to the nanostructure perimeters have higher strain energy, causing migration of As atoms towards the quantum wire terraces, where the structure is partially relaxed; the thickness of the wetting layer is reduced in these zones and the island height increases until the (001) facet is removed.
Shchepunov, V A; Cappuzzello, F; Foti, A; Lazzaro, A; Melita, A L; Nociforo, C; Winfield, J S
2003-01-01
The large angular (approx 50 msr) and momentum (approx 20%) acceptance spectrometer MAGNEX is under construction at the South National Laboratories INFN. In the spectrometer, positions of ions in two planes near the focal plane and their vertical positions near the target are measured. The energy resolution of about 1000 is achieved due to the use of the reconstruction of trajectories and reconstructive correction of aberrations. Main features of the spectrometer ion optics are considered. A numerical method of calculation of an arbitrary order transfer map is proposed. In this method, a transfer map is calculated using, as input, initial and final coordinates of a set of rays in an ion-optical system. The rays start at the nods of a regular multi-dimensional mesh in the particle phase space. Rays of the set are chosen automatically according to the order and dimension of the map to be calculated. Final coordinates of the rays are calculated with a regular numerical integration. The proposed is, in fact, a ge...
Sales, D L; Molina, S I [Departamento de Ciencia de los Materiales e I. M. y Q. I., Universidad de Cadiz, Campus Rio San Pedro, E-11510 Puerto Real, Cadiz (Spain); Varela, M; Pennycook, S J [Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Galindo, P L [Departamento de Lenguajes y Sistemas Informaticos, Universidad de Cadiz, Campus Rio San Pedro, E-11510 Puerto Real, Cadiz (Spain); Gonzalez, L; Gonzalez, Y [Instituto de Microelectronica de Madrid (CNM, CSIC), Isaac Newton 8, E-28760 Tres Cantos, Madrid (Spain); Fuster, D, E-mail: david.sales@uca.es [UMDO - Unidad Asociada al CSIC-IMM, Instituto de Ciencia de Materiales, Universidad de Valencia, PO Box 22085, 4607 Valencia (Spain)
2010-08-13
Evolution of the size, shape and composition of self-assembled InAs/InP quantum wires through the Stranski-Krastanov transition has been determined by aberration-corrected Z-contrast imaging. High resolution compositional maps of the wires in the initial, intermediate and final formation stages are presented. (001) is the main facet at their very initial stage of formation, which is gradually reduced in favour of {l_brace}114{r_brace} or {l_brace}118{r_brace}, ending with the formation of mature quantum wires with {l_brace}114{r_brace} facets. Significant changes in wire dimensions are measured when varying slightly the amount of InAs deposited. These results are used as input parameters to build three-dimensional models that allow calculation of the strain energy during the quantum wire formation process. The observed morphological evolution is explained in terms of the calculated elastic energy changes at the growth front. Regions of the wetting layer close to the nanostructure perimeters have higher strain energy, causing migration of As atoms towards the quantum wire terraces, where the structure is partially relaxed; the thickness of the wetting layer is reduced in these zones and the island height increases until the (001) facet is removed.
J2 invariant relative orbits via differential correction algorithm
Ming Xu; Shijie Xu
2007-01-01
This paper describes a practical method for finding the invariant orbits in J2 relative dynamics. Working with the Hamiltonian model of the relative motion in cludingthe J2 perturbation, the effective differential correction algorithm for finding periodic orbits in three-body problem is extended to formation flying of Earth's orbiters. Rather than using orbital elements, the analysis is done directly in physical space, which makes a direct connection with physical requirements. The asymptotic behavior of the invariant orbit is indicated by its stable and unstable manifolds. The period of the relative orbits is proved numerically to be slightly different from the ascending node period of the leader satellite,and a preliminary explanation for this phenomenon is presented. Then the compatibility between J2 invariant orbit and desired relative geometry is considered, and the design procedure for the initial values of the compatible configurationis proposed. The influences of measure errors on the invariantorbit are also investigated by the Monte-Carlo simulation.
Mahalingam, Krishnamurthy, E-mail: Krishnamurthy.Mahalingam.ctr@wpafb.af.mil [Air Force Research Laboratory, Wright-Patterson AFB, OH 45433-7707 (United States); Haugan, Heather J.; Brown, Gail J.; Eyink, Kurt G. [Air Force Research Laboratory, Wright-Patterson AFB, OH 45433-7707 (United States)
2013-04-15
The strain distribution across interfaces in InAs/GaSb superlattices grown on (100)-GaSb substrates is investigated by aberration corrected transmission electron microscopy. Atomic resolution images of interfaces were obtained by conventional high resolution transmission electron microscopy (HRTEM), using the negative spherical-aberration imaging mode, and by scanning transmission electron microscopy (STEM), using the high-angle annular dark-field (HAADF) imaging mode. The local atomic displacements across interfaces were determined from these images using the peak pair algorithm, from which strain maps were calculated with respect to a reference lattice extracted from the GaSb substrate region. Both techniques yield consistent results, which reveal that the InAs-on-GaSb interface is nearly strain balanced, whereas the GaSb-on-InAs interface is in tensile strain, indicating that the prevalent bond type at this interface is Ga–As. In addition, the GaSb layers in the superlattice are compressively strained indicating the incorporation of In into these layers. Further analysis of the HAADF-STEM images indicates an estimated 4% In content in the GaSb layers and that the GaSb-on-InAs interface contributes to about 27% of the overall superlattice strain. The strain measurements in the InAs layers are in good agreement with the theoretical values determined from elastic constants. Furthermore, the overall superlattice strain determined from this analysis is also in good agreement with the measurements determined by high-resolution X-ray diffraction. - Highlights: ►The strain distribution across interfaces in InAs–GaSb superlattices is examined. ► The GaSb-on-InAs interfaces are tensile, accounting for 27% of the overall strain. ► The InAs-on-GaSb interfaces are strain neutral. ► The GaSb layers are in compressive strain due to indium incorporation of about 4%. ► The strain in InAs layers is tensile, and is close to the bulk value of about 1%.
Evaluation of Correction Algorithm for the Reflectance Measured with Optical Glass
车江宁; 周志华; 陈东辉
2003-01-01
The proposed algorithm for reflectance measured with optical glass has been verified with materials of various forms. The refiectances measured with optical glass (raw), without glass (true) and corrected by the algorithm are compared. The results show that the corrected reflectance agrees very well with true one and their color differences fall below the acceptable limit, which indicates the validity of the correction algorithm. The algorithm could be used not only for fiber-forming materials, but also for powder- forming, granulate-forming, etc.
Study on battery state of charge correct algorithm of electric vehicle
KAN Ping; QIAN Lijun
2012-01-01
State of Charge （SOC） is used to adjust the initialization SOC value so as to make electric vehicle simulation results close to real vehicle performance. This paper firstly analyses the battery SOC correct algorithm, then uses ADVISOR which is a electric vehicle simulation software to simulate a hybrid electric car with three different cases of no SOC correct, linear SOC correct and zero delta SOC correct, as well as makes the compare and analysis for those simulation results. In the end, an overall conclusion to SOC correct algorithm is given.
Jin, Minglei; Jin, Weiqi; Li, Yiyang; Li, Shuo
2015-08-01
In this paper, we propose a novel scene-based non-uniformity correction algorithm for infrared image processing-temporal high-pass non-uniformity correction algorithm based on grayscale mapping (THP and GM). The main sources of non-uniformity are: (1) detector fabrication inaccuracies; (2) non-linearity and variations in the read-out electronics and (3) optical path effects. The non-uniformity will be reduced by non-uniformity correction (NUC) algorithms. The NUC algorithms are often divided into calibration-based non-uniformity correction (CBNUC) algorithms and scene-based non-uniformity correction (SBNUC) algorithms. As non-uniformity drifts temporally, CBNUC algorithms must be repeated by inserting a uniform radiation source which SBNUC algorithms do not need into the view, so the SBNUC algorithm becomes an essential part of infrared imaging system. The SBNUC algorithms' poor robustness often leads two defects: artifacts and over-correction, meanwhile due to complicated calculation process and large storage consumption, hardware implementation of the SBNUC algorithms is difficult, especially in Field Programmable Gate Array (FPGA) platform. The THP and GM algorithm proposed in this paper can eliminate the non-uniformity without causing defects. The hardware implementation of the algorithm only based on FPGA has two advantages: (1) low resources consumption, and (2) small hardware delay: less than 20 lines, it can be transplanted to a variety of infrared detectors equipped with FPGA image processing module, it can reduce the stripe non-uniformity and the ripple non-uniformity.
Lu, Ping
2014-10-01
Controlling metallic nanoparticle (NP) interactions plays a vital role in the development of new joining techniques (nanosolder) that bond at lower processing temperatures but remain viable at higher temperatures. The pr imary objective of this project is t o develop a fundamental understanding of the actual reaction processes, associated atomic mechanisms, and the resulting microstructure that occur during thermally - driven bond formation concerning metal - metal nano - scale (%3C50nm) interfaces. In this LDRD pr oject, we have studied metallic NPs interaction at the elevated temperatures by combining in - situ transmission electron microscopy (TEM ) using an aberration - corrected scanning transmission electron microscope (AC - STEM) and atomic - scale modeling such as m olecular dynamic (MD) simulations. Various metallic NPs such as Ag, Cu and Au are synthesized by chemical routines. Numerous in - situ e xperiments were carried out with focus of the research on study of Ag - Cu system. For the first time, using in - situ STEM he ating experiments , we directly observed t he formation of a 3 - dimensional (3 - D) epitaxial Cu - Ag core - shell nanoparticle during the thermal interaction of Cu and Ag NPs at elevated temperatures (150 - 300 o C). The reaction takes place at temperatures as low as 150 o C and was only observed when care was taken to circumvent the effects of electron beam irradiation during STEM imaging. Atomic - scale modeling verified that the Cu - Ag core - shell structure is energetically favored, and indicated that this phenomenon is a nano - scale effect related to the large surface - to - volume ratio of the NPs. The observation potentially can be used for developing new nanosolder technology that uses Ag shell as the "glue" that stic ks the particles of Cu together. The LDRD has led to several journal publications and numerous conference presentations, and a TA. In addition, we have developed new TEM characterization techniques and phase
An Illumination Correction ALgorithm on Landsat-TM Data
Tan, Bin; Wolfe, Robert; Masek, Jeffrey; Gao, Feng; Vermote, Eric F.
2010-01-01
In this paper, a new illumination correction model, the rotation model, is introduced. The model is based on the empirical correlation between reflectance and the illumination condition (IL). The model eliminates the dependency of reflectance on IL through rotating the data in IL-reflectance space. This model is compared with widely used cosine model and C model over a sample forest region. We found that the newly developed rotation model consistently performs best on both atmospheric uncorrected and corrected Landsat images. Index Terms Landsat, illumination correction, change detection, LEDAPS
Ahmadian, Alireza; Ay, Mohammad R.; Sarkar, Saeed [Medical Sciences/University of Tehran, Research Center for Science and Technology in Medicine, Tehran (Iran); Medical Sciences/University of Tehran, Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran (Iran); Bidgoli, Javad H. [Medical Sciences/University of Tehran, Research Center for Science and Technology in Medicine, Tehran (Iran); East Tehran Azad University, Department of Electrical and Computer Engineering, Tehran (Iran); Zaidi, Habib [Geneva University Hospital, Division of Nuclear Medicine, Geneva (Switzerland)
2008-10-15
Oral contrast is usually administered in most X-ray computed tomography (CT) examinations of the abdomen and the pelvis as it allows more accurate identification of the bowel and facilitates the interpretation of abdominal and pelvic CT studies. However, the misclassification of contrast medium with high-density bone in CT-based attenuation correction (CTAC) is known to generate artifacts in the attenuation map ({mu}map), thus resulting in overcorrection for attenuation of positron emission tomography (PET) images. In this study, we developed an automated algorithm for segmentation and classification of regions containing oral contrast medium to correct for artifacts in CT-attenuation-corrected PET images using the segmented contrast correction (SCC) algorithm. The proposed algorithm consists of two steps: first, high CT number object segmentation using combined region- and boundary-based segmentation and second, object classification to bone and contrast agent using a knowledge-based nonlinear fuzzy classifier. Thereafter, the CT numbers of pixels belonging to the region classified as contrast medium are substituted with their equivalent effective bone CT numbers using the SCC algorithm. The generated CT images are then down-sampled followed by Gaussian smoothing to match the resolution of PET images. A piecewise calibration curve was then used to convert CT pixel values to linear attenuation coefficients at 511 keV. The visual assessment of segmented regions performed by an experienced radiologist confirmed the accuracy of the segmentation and classification algorithms for delineation of contrast-enhanced regions in clinical CT images. The quantitative analysis of generated {mu}maps of 21 clinical CT colonoscopy datasets showed an overestimation ranging between 24.4% and 37.3% in the 3D-classified regions depending on their volume and the concentration of contrast medium. Two PET/CT studies known to be problematic demonstrated the applicability of the technique
CAAS: an atmospheric correction algorithm for the remote sensing of complex waters
P. Shanmugam
2012-01-01
Full Text Available The current SeaDAS atmospheric correction algorithm relies on the computation of optical properties of aerosols based on radiative transfer combined with a near-infrared (NIR correction scheme (originally with assumptions of zero water-leaving radiance for the NIR bands and several ancillary parameters to remove atmospheric effects in remote sensing of ocean colour. The failure of this algorithm over complex waters has been reported by many recent investigations, and can be attributed to the inadequate NIR correction and constraints for deriving aerosol optical properties whose characteristics are the most difficult to evaluate because they vary rapidly with time and space. The possibility that the aerosol and sun glint contributions can be derived in the whole spectrum of ocean colour solely from a knowledge of the total and Rayleigh-corrected radiances is developed in detail within the framework of a Complex water Atmospheric correction Algorithm Scheme (CAAS that makes no use of ancillary parameters. The performance of the CAAS algorithm is demonstrated for MODIS/Aqua imageries of optically complex waters and yields physically realistic water-leaving radiance spectra that are not possible with the SeaDAS algorithm. A preliminary comparison with in-situ data for several regional waters (moderately complex to clear waters shows encouraging results, with absolute errors of the CAAS algorithm closer to those of the SeaDAS algorithm. The impact of the atmospheric correction was also examined on chlorophyll retrievals with a Case 2 water bio-optical algorithm, and it was found that the CAAS algorithm outperformed the SeaDAS algorithm in terms of producing accurate pigment estimates and recovering areas previously flagged out by the later algorithm. These findings suggest that the CAAS algorithm can be used for applications focussing in quantitative assessments of the biological and biogeochemical properties in complex waters, and can easily be
Algorithms for Relative Radiometric Correction in Earth Observing Systems Resource-P and Canopus-V
Zenin, V. A.; Eremeev, V. V.; Kuznetcov, A. E.
2016-06-01
The present paper has considered two algorithms of the relative radiometric correction of information obtained from a multimatrix imagery instrument of the spacecraft "Resource-P" and frame imagery systems of the spacecraft "Canopus-V". The first algorithm is intended for elimination of vertical stripes on the image that are caused by difference in transfer characteristics of CCD matrices and CCD detectors. Correction coefficients are determined on the basis of analysis of images that are homogeneous by brightness. The second algorithm ensures an acquisition of microframes homogeneous by brightness from which seamless images of the Earth surface are synthesized. Examples of practical usage of the developed algorithms are mentioned.
Convolution kernel design and efficient algorithm for sampling density correction.
Johnson, Kenneth O; Pipe, James G
2009-02-01
Sampling density compensation is an important step in non-cartesian image reconstruction. One of the common techniques to determine weights that compensate for differences in sampling density involves a convolution. A new convolution kernel is designed for sampling density attempting to minimize the error in a fully reconstructed image. The resulting weights obtained using this new kernel are compared with various previous methods, showing a reduction in reconstruction error. A computationally efficient algorithm is also presented that facilitates the calculation of the convolution of finite kernels. Both the kernel and the algorithm are extended to 3D. Copyright 2009 Wiley-Liss, Inc.
QR Code Image Correction based on Corner Detection and Convex Hull Algorithm
Suran Kong
2013-12-01
Full Text Available Since the angular deviation produced when shooting a QR code image by a camera would cause geometric distortion of the QR code image, the traditional algorithm of QR code image correction would produce distortion. Therefore this paper puts forward the algorithm which combines corner detection with convex hull algorithm. Firstly, binaryzation of the collected QR code image with uneven light is obtained by the methods of local threshold and mathematical morphology. Next, the outline of the QR code and the dots on it are found and the distorted image is recovered by perspective collineation, according to the algorithm raised by this paper. Finally, experimental verification is made that the algorithm raised by this paper can correctly find the four apexes of QR code and achieves good effects of geometric correction. It will also significantly increase the recognition rate of seriously distorted QR code images
Weighted SVD algorithm for close-orbit correction and 10 Hz feedback in RHIC
Liu C.; Hulsart, R.; Marusic, A.; Michnoff, R.; Minty, M.; Ptitsyn, V.
2012-05-20
Measurements of the beam position along an accelerator are typically treated equally using standard SVD-based orbit correction algorithms so distributing the residual errors, modulo the local beta function, equally at the measurement locations. However, sometimes a more stable orbit at select locations is desirable. In this paper, we introduce an algorithm for weighting the beam position measurements to achieve a more stable local orbit. The results of its application to close-orbit correction and 10 Hz orbit feedback are presented.
Maloney, J A; Derbenev, Ya S; Afanasev, A; Johnson, R P; Ankenbrandt, C A; Yoshikawa, C; Yonehara, K; Neuffer, D; Erdelyi, B
2014-01-01
Muon colliders have been proposed for the next generation of particle accelerators that study high-energy physics at the energy and intensity frontiers. In this paper we study a possible implementation of muon ionization cooling, Parametric-resonance Ionization Cooling (PIC), in the twin helix channel. The resonant cooling method of PIC offers the potential to reduce emittance beyond that achievable with ionization cooling with ordinary magnetic focusing. We examine optimization of a variety of parameters, study the nonlinear dynamics in the twin helix channel and consider possible methods of aberration correction.
LI Zhipeng; CHEN Shanguang; XUE Liang
2003-01-01
Baum-Welch algorithm most likely results in underflow in practice. In some lit-eratures, such as "Scaling" algorithm was introduced to solve the problem. In applications,however, some mistakes were found in the equations presented in these literatures. The practi-cal calculations show that the original algorithm often results in poor or even none convergenceand rather higher error rate in speech recognition. The mistakes in these literatures and bringsforward the correct equations are analysed. The speech recognition system using the revisedalgorithm can converge well and has lower error rate.
A Genetic Algorithm for Chromaticity Correction in Diffraction Limited Storage Rings
Ehrlichman, Michael
2016-01-01
An multi-objective genetic algorithm is developed for optimizing nonlinearities in diffraction limited storage rings. This algorithm determines sextupole and octupole strengths for chromaticity correction that deliver optimized dynamic aperture and beam lifetime. The algorithm makes use of dominance constraints to breed desirable properties into the early generations. The momentum aperture is optimized indirectly by constraining the chromatic tune footprint and optimizing the off-energy dynamic aperture. The result is an effective and computationally efficient technique for correcting chromaticity in a storage ring while maintaining optimal dynamic aperture and beam lifetime. This framework was developed for the Swiss Light Source (SLS) upgrade project.
Schöberl, Iris; Kortekaas, Kim; Schöberl, Franz F; Kotrschal, Kurt
2015-12-01
Dog heart rate (HR) is characterized by a respiratory sinus arrhythmia, and therefore makes an automatic algorithm for error correction of HR measurements hard to apply. Here, we present a new method of error correction for HR data collected with the Polar system, including (1) visual inspection of the data, (2) a standardized way to decide with the aid of an algorithm whether or not a value is an outlier (i.e., "error"), and (3) the subsequent removal of this error from the data set. We applied our new error correction method to the HR data of 24 dogs and compared the uncorrected and corrected data, as well as the algorithm-supported visual error correction (AVEC) with the Polar error correction. The results showed that fewer values were identified as errors after AVEC than after the Polar error correction (p error correction is more suitable for dog HR and HR variability than is the customized Polar error correction, especially because AVEC decreases the likelihood of Type I errors, preserves the natural variability in HR, and does not lead to a time shift in the data.
Self-Correcting HVAC Controls: Algorithms for Sensors and Dampers in Air-Handling Units
Fernandez, Nicholas; Brambley, Michael R.; Katipamula, Srinivas
2009-12-31
This report documents the self-correction algorithms developed in the Self-Correcting Heating, Ventilating and Air-Conditioning (HVAC) Controls project funded jointly by the Bonneville Power Administration and the Building Technologies Program of the U.S. Department of Energy. The algorithms address faults for temperature sensors, humidity sensors, and dampers in air-handling units and correction of persistent manual overrides of automated control systems. All faults considered create energy waste when left uncorrected as is frequently the case in actual systems.
保金华; 贺极苍; 毛欣杰; 吕帆
2013-01-01
Background Even though the change in wavefront aberrations with correction modality is well documented in the literature,little is known about the underlying mechanism.Complete understanding of the causes responsible for the wavefront change in the combined lens-eye system is important since it provides basic knowledge for further improving the technique to correct refractive error by correcting lenses.Objective The aim of this study was to investigate the influence of refractive correction lens on optical property of the eye by analyzing Zernike aberrations in myopic eyes with contact lens correction.Methods This study was approved by the Ethic Committee of Wenzhou Medical College.Written informed consent was obtained from each subject before entering this study.Zernike aberrations of 52 myopic eyes of 26 subjects with the spherical equivalent-1.75 to-8.50 D were measured using a Hartmann-Shock wavefront sensor.The human eye aberrations were examined at the uncorrected condition,rigid-gas-permeable contact lens (RGP-CL) corrected condition and soft contact lens (Soft-CL) corrected condition.The differences of wavefront aberrations and Zernike coefficients were compared by repeated measurement of single factor variance analysis,and correlation of the aberration changes between uncorrected condition and RGP-CL corrected condition or Sofi-CL corrected condition,between the right eyes and left eyes in different conditions were analyzed by Pearson linear correlation.Results Mean total root-mean-square (tRMS) was (0.71 ± 0.30)μm,(0.54±0.19)μm and (0.74±0.32)μm in the uncorrected condition,RGP-CL corrected condition and Soft-CL corrected condition,with a significant difference (F =8.758,P＜0.001),and tRMS was significant declined under the RGP-CL corrected condition compared with uncorrected condition (t =2.746,P =0.008),and tRMS in RGP-CL corrected condition was significantly lower than that in Soft-CL corrected condition (t =3.428,P =0.001).The high RMS (h
Application of the Beetle Header cross-talk correction algorithm for the VELO Detector
Szumlak, T
2010-01-01
The front-end chip of the VELO detector is known as the Beetle. The data obtained from the VELO strips is proceeded by header bits. The value of these header bits can affect the signal data of the VELO. This causes increased noise on one in every 32 channels of the VELO detector. An algorithm to correct this cross-talk has been implemented in the TELL1 readout board of the VELO detector. The correction coefficients for this algorithm can be calculated through the analysis of non-zero suppressed data in the VELO analysis package VETRA. This note presents a study of this cross-talk effect, an evaluation of the effectiveness of the algorithm implemented, a procedure to calculate the required correction coefficients for the algorithm, and a method to monitor the performance of this algorithm. The algorithm is found to provide suitable compensation on test beam data where significant corrections were required. In the final system, with optimized digitization timing, the corrections required are found to be smaller...
Post-Editing Error Correction Algorithm for Speech Recognition using Bing Spelling Suggestion
Bassil, Youssef
2012-01-01
ASR short for Automatic Speech Recognition is the process of converting a spoken speech into text that can be manipulated by a computer. Although ASR has several applications, it is still erroneous and imprecise especially if used in a harsh surrounding wherein the input speech is of low quality. This paper proposes a post-editing ASR error correction method and algorithm based on Bing's online spelling suggestion. In this approach, the ASR recognized output text is spell-checked using Bing's spelling suggestion technology to detect and correct misrecognized words. More specifically, the proposed algorithm breaks down the ASR output text into several word-tokens that are submitted as search queries to Bing search engine. A returned spelling suggestion implies that a query is misspelled; and thus it is replaced by the suggested correction; otherwise, no correction is performed and the algorithm continues with the next token until all tokens get validated. Experiments carried out on various speeches in differen...
Matsumoto, Naoya; Inoue, Takashi; Matsumoto, Akiyuki; Okazaki, Shigetoshi
2015-07-01
We demonstrate fluorescence imaging with high fluorescence intensity and depth resolution in which depth-induced spherical aberration (SA) caused by refractive-index mismatch between the medium and biological sample is corrected. To reduce the impact of SA, we incorporate a spatial light modulator into a two-photon excitation fluorescence microscope. Consequently, when fluorescent beads in epoxy resin were observed with this method of SA correction, the fluorescence signal of the observed images was ∼27 times higher and extension in the direction of the optical axes was ∼6.5 times shorter at a depth of ∼890 μm. Thus, the proposed method increases the depth observable at high resolution. Further, our results show that the method improved the fluorescence intensity of images of the fluorescent beads and the structure of a biological sample.
Gamm, B.; Schultheiß, K.; Schröder, R. R.; Gerthsen, D.
2010-01-01
In this theoretical study we analyze contrast transfer of weak-phase objects in a transmission electron microscope, which is equipped with an aberration corrector (Cs-corrector) in the imaging lens system and a physical phase plate in the back focal plane of the objective lens. For a phase shift of pi/2 between scattered and unscattered electrons induced by a physical phase plate, the sine-type phase contrast transfer function is converted into a cosine-type function. Optimal imaging conditio...
Xiaole Shen
2015-09-01
Full Text Available The uneven illumination phenomenon caused by thin clouds will reduce the quality of remote sensing images, and bring adverse effects to the image interpretation. To remove the effect of thin clouds on images, an uneven illumination correction can be applied. In this paper, an effective uneven illumination correction algorithm is proposed to remove the effect of thin clouds and to restore the ground information of the optical remote sensing image. The imaging model of remote sensing images covered by thin clouds is analyzed. Due to the transmission attenuation, reflection, and scattering, the thin cloud cover usually increases region brightness and reduces saturation and contrast of the image. As a result, a wavelet domain enhancement is performed for the image in Hue-Saturation-Value (HSV color space. We use images with thin clouds in Wuhan area captured by QuickBird and ZiYuan-3 (ZY-3 satellites for experiments. Three traditional uneven illumination correction algorithms, i.e., multi-scale Retinex (MSR algorithm, homomorphic filtering (HF-based algorithm, and wavelet transform-based MASK (WT-MASK algorithm are performed for comparison. Five indicators, i.e., mean value, standard deviation, information entropy, average gradient, and hue deviation index (HDI are used to analyze the effect of the algorithms. The experimental results show that the proposed algorithm can effectively eliminate the influences of thin clouds and restore the real color of ground objects under thin clouds.
A curvature filter and PDE based non-uniformity correction algorithm
Cheng, Kuanhong; Zhou, Huixin; Qin, Hanlin; Zhao, Dong; Qian, Kun; Rong, Shenghui; Yin, Shimin
2016-10-01
In this paper, a curvature filter and PDE based non-uniformity correction algorithm is proposed, the key point of this algorithm is the way to estimate FPN. We use anisotropic diffusion to smooth noise and Gaussian curvature filter to extract the details of original image. Then combine these two parts together by guided image filter and subtract the result from original image to get the crude approximation of FPN. After that, a Temporal Low Pass Filter (TLPF) is utilized to filter out random noise and get the accurate FPN. Finally, subtract the FPN from original image to achieve non-uniformity correction. The performance of this algorithm is tested with two infrared image sequences, and the experimental results show that the proposed method achieves a better non-uniformity correction performance.
A First-order Prediction-Correction Algorithm for Time-varying (Constrained) Optimization: Preprint
Dall-Anese, Emiliano [National Renewable Energy Laboratory (NREL), Golden, CO (United States)
2017-07-25
This paper focuses on the design of online algorithms based on prediction-correction steps to track the optimal solution of a time-varying constrained problem. Existing prediction-correction methods have been shown to work well for unconstrained convex problems and for settings where obtaining the inverse of the Hessian of the cost function can be computationally affordable. The prediction-correction algorithm proposed in this paper addresses the limitations of existing methods by tackling constrained problems and by designing a first-order prediction step that relies on the Hessian of the cost function (and do not require the computation of its inverse). Analytical results are established to quantify the tracking error. Numerical simulations corroborate the analytical results and showcase performance and benefits of the algorithms.
Ziyi Fu
2012-10-01
Full Text Available According to the upstream TDM in the system of Ethernet passive optical network (EPON, this paper proposes a novel dynamic bandwidth allocation algorithm which supports the mechanism with correction-based the multiple services estimation. To improve the real-time performance of the bandwidth allocation, this algorithm forecasts the traffic of high priority services, and then pre-allocate bandwidth for various priority services is corrected according to Gaussian distribution characteristics, which will make traffic prediction closer to the real traffic. The simulation results show that proposed algorithm is better than the existing DBA algorithm. Not only can it meet the delay requirement of high priority services, but also control the delay abnormity of low priority services. In addition, with rectification scheme, it obviously improves the bandwidth utilization.
Actuator Disc Model Using a Modified Rhie-Chow/SIMPLE Pressure Correction Algorithm
Rethore, Pierre-Elouan; Sørensen, Niels
2008-01-01
An actuator disc model for the flow solver EllipSys (2D&3D) is proposed. It is based on a correction of the Rhie-Chow algorithm for using discreet body forces in collocated variable finite volume CFD code. It is compared with three cases where an analytical solution is known.......An actuator disc model for the flow solver EllipSys (2D&3D) is proposed. It is based on a correction of the Rhie-Chow algorithm for using discreet body forces in collocated variable finite volume CFD code. It is compared with three cases where an analytical solution is known....
A new adaptive nonuniformity correction algorithm for infrared line scanner based on neural networks
Jing Sui; Liquan Dong; Weiqi Jin; Yayuan Zhang
2007-01-01
The striping pattern nonuniformity of the infrared line scanner (IRLS) severely limits the system performance. An adaptive nonuniformity correction (NUC) algorithm for IRLS using neural network is proposed.It uses a one-dimensional median filter to generate ideal output of network and can complete NUC by a single frame with a high correction level. Applications to both simulated and real infrared images show that the algorithm can obtain a satisfactory result with low complexity, no need of scene diversity or global motion between consecutive frames. It has the potential to realize real-time hardware-based applications.
The generation algorithm of arbitrary polygon animation based on dynamic correction
Hou Ya Wei
2016-01-01
Full Text Available This paper, based on the key-frame polygon sequence, proposes a method that makes use of dynamic correction to develop continuous animation. Firstly we use quadratic Bezier curve to interpolate the corresponding sides vector of polygon sequence consecutive frame and realize the continuity of animation sequences. And then, according to Bezier curve characteristic, we conduct dynamic regulation to interpolation parameters and implement the changing smoothness. Meanwhile, we take use of Lagrange Multiplier Method to correct the polygon and close it. Finally, we provide the concrete algorithm flow and present numerical experiment results. The experiment results show that the algorithm acquires excellent effect.
Häussler, Dietrich [Institute for Materials Science, Christian-Albrechts-University Kiel, Kaiserstraße 2, 24143 Kiel (Germany); Houben, Lothar [Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons, Research Centre Juelich GmbH, 52425 Juelich (Germany); Essig, Stephanie [Fraunhofer Institute for Solar Energy Systems ISE, Heidenhofstraße 2, 79110 Freiburg (Germany); Kurttepeli, Mert [Institute for Materials Science, Christian-Albrechts-University Kiel, Kaiserstraße 2, 24143 Kiel (Germany); Dimroth, Frank [Fraunhofer Institute for Solar Energy Systems ISE, Heidenhofstraße 2, 79110 Freiburg (Germany); Dunin-Borkowski, Rafal E. [Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons, Research Centre Juelich GmbH, 52425 Juelich (Germany); Jäger, Wolfgang, E-mail: wolfgang.jaeger@tf.uni-kiel.de [Institute for Materials Science, Christian-Albrechts-University Kiel, Kaiserstraße 2, 24143 Kiel (Germany)
2013-11-15
Aberration-corrected scanning transmission electron microscopy (STEM) and electron energy loss spectroscopy (EELS) investigations have been applied to investigate the structure and composition fluctuations near interfaces in wafer-bonded multi-junction solar cells. Multi-junction solar cells are of particular interest since efficiencies well above 40% have been obtained for concentrator solar cells which are based on III-V compound semiconductors. In this methodologically oriented investigation, we explore the potential of combining aberration-corrected high-angle annular dark-field STEM imaging (HAADF-STEM) with spectroscopic techniques, such as EELS and energy-dispersive X-ray spectroscopy (EDXS), and with high-resolution transmission electron microscopy (HR-TEM), in order to analyze the effects of fast atom beam (FAB) and ion beam bombardment (IB) activation treatments on the structure and composition of bonding interfaces of wafer-bonded solar cells on Si substrates. Investigations using STEM/EELS are able to measure quantitatively and with high precision the widths and the fluctuations in element distributions within amorphous interface layers of nanometer extensions, including those of light elements. Such measurements allow the control of the activation treatments and thus support assessing electrical conductivity phenomena connected with impurity and dopant distributions near interfaces for optimized performance of the solar cells. - Highlights: • Aberration-corrected TEM and EELS reveal structural and elemental profiles across GaAs/Si bond interfaces in wafer-bonded GaInP/GaAs/Si - multi-junction solar cells. • Fluctuations in elemental concentration in nanometer-thick amorphous interface layers, including the disrubutions of light elements, are measured using EELS. • The projected widths of the interface layers are determined on the atomic scale from STEM-HAADF measurements. • The effects of atom and ion beam activation treatment on the bonding
DEVELOPMENT AND TESTING OF ERRORS CORRECTION ALGORITHM IN ELECTRONIC DESIGN AUTOMATION
E. B. Romanova
2016-03-01
Full Text Available Subject of Research. We have developed and presented a method of design errors correction for printed circuit boards (PCB in electronic design automation (EDA. Control of process parameters of PCB in EDA is carried out by means of Design Rule Check (DRC program. The DRC program monitors compliance with the design rules (minimum width of the conductors and gaps, the parameters of pads and via-holes, the parameters of polygons, etc. and also checks the route tracing, short circuits, the presence of objects outside PCB edge and other design errors. The result of the DRC program running is the generated error report. For quality production of circuit boards DRC-errors should be corrected, that is ensured by the creation of error-free DRC report. Method. A problem of correction repeatability of DRC-errors was identified as a result of trial operation of P-CAD, Altium Designer and KiCAD programs. For its solution the analysis of DRC-errors was carried out; the methods of their correction were studied. DRC-errors were proposed to be clustered. Groups of errors include the types of errors, which correction sequence has no impact on the correction time. The algorithm for correction of DRC-errors is proposed. Main Results. The best correction sequence of DRC-errors has been determined. The algorithm has been tested in the following EDA: P-CAD, Altium Designer and KiCAD. Testing has been carried out on two and four-layer test PCB (digital and analog. Comparison of DRC-errors correction time with the algorithm application to the same time without it has been done. It has been shown that time saved for the DRC-errors correction increases with the number of error types up to 3.7 times. Practical Relevance. The proposed algorithm application will reduce PCB design time and improve the quality of the PCB design. We recommend using the developed algorithm when the number of error types is equal to four or more. The proposed algorithm can be used in different
Automatic Correction Algorithm of Hyfrology Feature Attribute in National Geographic Census
Li, C.; Guo, P.; Liu, X.
2017-09-01
A subset of the attributes of hydrologic features data in national geographic census are not clear, the current solution to this problem was through manual filling which is inefficient and liable to mistakes. So this paper proposes an automatic correction algorithm of hydrologic features attribute. Based on the analysis of the structure characteristics and topological relation, we put forward three basic principles of correction which include network proximity, structure robustness and topology ductility. Based on the WJ-III map workstation, we realize the automatic correction of hydrologic features. Finally, practical data is used to validate the method. The results show that our method is highly reasonable and efficient.
Poppitz, David; Lotnyk, Andriy; Gerlach, Jürgen W; Lenzner, Jörg; Grundmann, Marius; Rauschenbach, Bernd
2015-06-01
Ion-beam assisted molecular-beam epitaxy was used for direct growth of epitaxial GaN thin films on super-polished 6H-SiC(0001) substrates. The GaN films with different film thicknesses were studied using reflection high energy electron diffraction, X-ray diffraction, cathodoluminescence and primarily aberration-corrected scanning transmission electron microscopy techniques. Special attention was devoted to the microstructural characterization of GaN thin films and the GaN-SiC interface on the atomic scale. The results show a variety of defect types in the GaN thin films and at the GaN-SiC interface. A high crystalline quality of the produced hexagonal GaN thin films was demonstrated. The gained results are discussed.
Kim, Hwang Su; Zhang, Zaoli; Kaiser, Ute
2012-06-01
This report is an extension of the study for structural imaging of 5-6 nm thick β-Si(3)N(4) [0001] crystal with a spherical aberration corrected transmission electron microscope by Zhang and Kaiser [2009. Structure imaging of β-Si(3)N(4) by spherical aberration-corrected high-resolution transmission electron microscopy. Ultramicroscopy 109, 1114-1120]. In this work, a local symmetry breaking with an uneven resolution of dumbbells in the six-membered rings revealed in the reported images in the study of Zhang and Kaiser has been analyzed in detail. It is found that this local asymmetry in the image basically is not relevant to a slight mistilt of the specimen and/or a beam tilt (coma). Rather the certain variation of the tetrahedral bond length of Si-N(4) in the crystal structure is found to be responsible for the uneven resolution with a local structural variation from region to region. This characteristic of the variation is also supposed to give a distorted lattice of apparently 2°-2.5° deviations from the perfect hexagonal unit cell as observed in the reported image in the work of Zhang and Kaiser. It is discussed that this variation may prevail only in a thin specimen with a thickness ranging ~≤ 5-6 nm. At the same time, it is noted that the average of the bond length variation is close to the fixed length known in a bulk crystal of β-Si(3)N(4).
The data correction algorithms in sup 6 sup 0 Co train inspection system
Yuan Ya Ding; LiuXiMing; Miao Ji Cheng
2002-01-01
Because of the physical characteristics of the sup 6 sup 0 Co train inspection system and the application of high-speed data collection system based on current integral, the original images have been distorted in a certain degree. Authors investigate into the reasons why the distortion comes into being, and accordingly present the data correction algorithm
Lee, Kwon-Ho; Kim, Wonkook
2017-04-01
The geostationary ocean color imager-II (GOCI-II), designed to be focused on the ocean environmental monitoring with better spatial (250m for local and 1km for full disk) and spectral resolution (13 bands) then the current operational mission of the GOCI-I. GOCI-II will be launched in 2018. This study presents currently developing algorithm for atmospheric correction and retrieval of surface reflectance over land to be optimized with the sensor's characteristics. We first derived the top-of-atmosphere radiances as the proxy data derived from the parameterized radiative transfer code in the 13 bands of GOCI-II. Based on the proxy data, the algorithm has been made with cloud masking, gas absorption correction, aerosol inversion, computation of aerosol extinction correction. The retrieved surface reflectances are evaluated by the MODIS level 2 surface reflectance products (MOD09). For the initial test period, the algorithm gave error of within 0.05 compared to MOD09. Further work will be progressed to fully implement the GOCI-II Ground Segment system (G2GS) algorithm development environment. These atmospherically corrected surface reflectance product will be the standard GOCI-II product after launch.
曲贺盟; 张新; 王灵杰
2012-01-01
The most significant feature of elliptical window optical system is dynamic aberration change which is dependent on the scanning field. Thus, astigmatism and coma become the main factors which influence imaging quality of the optical system and the effect of astigmatism is most prominent. In this paper, a new method for dynamic aberration correction was presented in order to solve this problem. And this so-called cylinder-Zernike element correcting method combines the characteristics of cylindrical lens and Zernike plate. The outer surfaces of cylinder-Zernike correcting element were a pair of cylindrical surfaces whose generating lines were mutual perpendicular and the corresponding internal surfaces were Zernike fringe sag surfaces. This method could adjust the distance between the two cylinder-Zernike correcting elements in real time according to the change of scanning field to realize the correcting of dynamic aberration induced by elliptical window. It breaks through the bottleneck that the fixed correcting elements cannot achieve super wide scanning field. The imaging optical system in the giving example achieves ±55° scanning field. The Zernike aberration coefficients of astigmatism and coma in each scanning field are corrected into ±0.8 wavelength and the imaging quality of the elliptical window optical system is greatly improved.%椭球形窗口光学系统最显著的特点在于其依赖扫描视场的动态像差变化特性,像散和彗差成为影响光学系统成像质量的主要因素,其中像散的影响最为突出.为解决这一难题,结合柱面透镜和泽尼克位相板的特点,提出了一种新颖的动态像差校正方法,即柱面-泽尼克元件校正方法,此元件的外表面为一对母线互相垂直的圆柱面,对应的两个内表面为泽尼克边缘矢高表面.该方法随扫描视场的变化实时地调整一对柱面-泽尼克校正元件间距以实现椭球形窗口引入像差的动态校正.突破了固定校
R. Muralidaran
2014-03-01
Full Text Available The influence of evolutionary algorithms enhanced its scope of getting its existence in almost every complex optimization problems. In this paper, cuckoo search algorithm, an algorithm based on the brood parasite behavior along with Levy weights has been proposed for the radiation pattern correction of a linear array of isotropic antennas with uniform spacing when failed with more than one antenna element. Even though deterioration produced by the failure of antenna elements results in various undesirable effects, consideration in this paper is given to the correction of side lobe level and null placement at two places. Various articles in the past have already shown that the idea to correct the radiation pattern is to alter the amplitude weights of the remaining unfailed elements, instead of replacing the faulty elements. This approach is made use of modifying the current excitations of unfailed elements using cuckoo search algorithm such that the resulting radiation pattern is similar to the unfailed original pattern in terms of side lobe level and null placement at two places. Examples shown in this paper demonstrate the effectiveness of this algorithm in achieving the desired objectives.
Sima Rani Dey
2012-04-01
Full Text Available Parametric models are mainly based on univariate or multivariate normality assumptions. Uniformly most powerful (UMP test is not available to test multivariate normality. In such a situation, optimal test can be used. But, a very few literature is available on the size corrected power comparison of different multivariate normality tests. In this paper, we propose an algorithm to compare the size corrected powers for testing univariate or multivariate normality. The algorithm can be applied to any existing univariate and multivariate tests, which is the most attractive feature of the proposed new algorithm. We also propose a Cholesky decomposition of the variance-covariance matrix based test, which is simpler than the existing test. Our Monte Carlo simulation study indicates that our proposed and existing tests perform equally in terms of power properties. Keywords— Cholesky decomposition, UMP test, Optimal test, Monte Carlo.
A survey of the baseline correction algorithms for real-time spectroscopy processing
Liu, Yuanjie; Yu, Yude
2016-11-01
In spectroscopy data analysis, such as Raman spectra, X-ray diffraction, fluorescence and etc., baseline drift is a ubiquitous issue. In high speed testing which generating huge data, automatic baseline correction method is very important for efficient data processing. We will survey the algorithms from classical Shirley background to state-of-the-art methods to present a summation for this specific field. Both advantages and defects of each algorithm are scrutinized. To compare the algorithms with each other, experiments are also carried out under SVM gap gain criteria to show the performance quantitatively. Finally, a rank table of these methods is built and the suggestions for practical choice of adequate algorithms is provided in this paper.
Infrared traffic image enhancement algorithm based on dark channel prior and gamma correction
Zheng, Lintao; Shi, Hengliang; Gu, Ming
2017-07-01
The infrared traffic image acquired by the intelligent traffic surveillance equipment has low contrast, little hierarchical differences in perceptions of image and the blurred vision effect. Therefore, infrared traffic image enhancement, being an indispensable key step, is applied to nearly all infrared imaging based traffic engineering applications. In this paper, we propose an infrared traffic image enhancement algorithm that is based on dark channel prior and gamma correction. In existing research dark channel prior, known as a famous image dehazing method, here is used to do infrared image enhancement for the first time. Initially, in the proposed algorithm, the original degraded infrared traffic image is transformed with dark channel prior as the initial enhanced result. A further adjustment based on the gamma curve is needed because initial enhanced result has lower brightness. Comprehensive validation experiments reveal that the proposed algorithm outperforms the current state-of-the-art algorithms.
A Parallel Decoding Algorithm for Short Polar Codes Based on Error Checking and Correcting
Pan, Xiaofei; Pan, Kegang; Ye, Zhan; Gong, Chao
2014-01-01
We propose a parallel decoding algorithm based on error checking and correcting to improve the performance of the short polar codes. In order to enhance the error-correcting capacity of the decoding algorithm, we first derive the error-checking equations generated on the basis of the frozen nodes, and then we introduce the method to check the errors in the input nodes of the decoder by the solutions of these equations. In order to further correct those checked errors, we adopt the method of modifying the probability messages of the error nodes with constant values according to the maximization principle. Due to the existence of multiple solutions of the error-checking equations, we formulate a CRC-aided optimization problem of finding the optimal solution with three different target functions, so as to improve the accuracy of error checking. Besides, in order to increase the throughput of decoding, we use a parallel method based on the decoding tree to calculate probability messages of all the nodes in the decoder. Numerical results show that the proposed decoding algorithm achieves better performance than that of some existing decoding algorithms with the same code length. PMID:25540813
A Parallel Decoding Algorithm for Short Polar Codes Based on Error Checking and Correcting
Yingxian Zhang
2014-01-01
Full Text Available We propose a parallel decoding algorithm based on error checking and correcting to improve the performance of the short polar codes. In order to enhance the error-correcting capacity of the decoding algorithm, we first derive the error-checking equations generated on the basis of the frozen nodes, and then we introduce the method to check the errors in the input nodes of the decoder by the solutions of these equations. In order to further correct those checked errors, we adopt the method of modifying the probability messages of the error nodes with constant values according to the maximization principle. Due to the existence of multiple solutions of the error-checking equations, we formulate a CRC-aided optimization problem of finding the optimal solution with three different target functions, so as to improve the accuracy of error checking. Besides, in order to increase the throughput of decoding, we use a parallel method based on the decoding tree to calculate probability messages of all the nodes in the decoder. Numerical results show that the proposed decoding algorithm achieves better performance than that of some existing decoding algorithms with the same code length.
An improved TES algorithm based on the corrected ALPHA difference spectrum
TANG ShiHao; LI XiaoWen; WANG JinDi; ZHU QiJiang; ZHANG LiHua
2007-01-01
Different from visible signals, thermal infrared radiances depend on both temperature and emissivity. It is a key problem for us to separate temperature and emissivity in thermal infrared remote sensing research. Another difficulty encountered in the retrieval of surface temperature is the correction of downwelling sky irradiance, because it is closely related to surface emissivity. When emissivity is unknown, the downwelling sky irradiance is difficult to be removed. In this paper, we introduce a correction term of downwelling sky irradiance developed by Li and Becker into Wien's approximation, to derive an improved ALPHA difference spectrum which is independent of temperature, and furthermore develop a correction term to remove the error of Wien's approximation. Under the support of the above work, attractive features of Alpha derived emissivity method and ASTER TES algorithm are combined together to acquire a new Improved TES algorithm based on Corrected ALPHA Difference Spectrum (ICADS TES). Because a multi-band inversion technique is applied, and the operations of band ratios and differences are included in the algorithm, it can partly remove the influence of atmosphere and noises. Numerical simulation experiments show that for various combinations of atmosphere, land covers and surface temperatures, the algorithm is applicable and stable. Its accuracy for temperature is 0―1.5 K, and that for emissivity is 0―0.015. Compared with current TES algorithms, our method has clear physical meaning, is easy to be implemented, and is applicable for a wide temperature range and surface types. The results are not influenced by the directional characteristic of emissivity. Because ICADS TES does not need the support of a priori information of surface types, it is also not influenced by the accuracy of classification and the problem of mixture pixels. Compared with our former TES algorithm based on corrected Alpha difference spectra (CADS TES), the new algorithm takes
Shemer, A.; Schwarz, A.; Gur, E.; Cohen, E.; Zalevsky, Z.
2015-04-01
In this paper, the authors describe a novel technique for image nonlinearity and non-uniformity corrections in imaging systems based on gamma detectors. The limitation of the gamma detector prevents the producing of high quality images due to the radionuclide distribution. This problem causes nonlinearity and non-uniformity distortions in the obtained image. Many techniques have been developed to correct or compensate for these image artifacts using complex calibration processes. The presented method is based on the Papoulis - Gerchberg(PG) iterative algorithm and is obtained without need of detector calibration, tuning process or using any special test phantom.
Kadkhodazadeh, Shima; Semenova, Elizaveta; Yvind, Kresten;
2011-01-01
The emission wavelength of InAs quantum dots grown on InP has been shown to shift to the technologically desirable 1.5μm with the deposition of 1–2 monolayers of GaAs on top of the quantum dots. Here, we use aberration-corrected scanning transmission electron microscopy to investigate morphologic...
A residual range cell migration correction algorithm for bistatic forward-looking SAR
Pu, Wei; Huang, Yulin; Wu, Junjie; Yang, Jianyu; Li, Wenchao
2016-12-01
For bistatic forward-looking synthetic aperture radar (BFSAR), images are often blurred by uncompensated radar motion errors. To get refocused images, autofocus is a useful postprocessing technique. However, a severe drawback of the autofocus algorithms is that they are only capable of removing one-dimensional azimuth phase errors. In BFSAR, motion errors and approximations of imaging algorithms introduce residual range cell migration (RCM) on BFSAR data as well. When residual RCM is within a range resolution cell, it can be neglected. However, the residual migration, which exceeds a range cell, is increasingly encountered as resolution becomes finer and finer. A novel residual RCM correction method is proposed in this paper. By fitting the low-frequency phase difference of adjacent azimuth cells, residual RCM of each azimuth cell can be corrected precisely and effectively. Simulations and real data experiments are carried out to validate the effectiveness of the proposed method.
Luo, Shouhua; Wu, Huazhen; Sun, Yi; Li, Jing; Li, Guang; Gu, Ning
2017-03-01
The beam hardening effect can induce strong artifacts in CT images, which result in severely deteriorated image quality with incorrect intensities (CT numbers). This paper develops an effective and efficient beam hardening correction algorithm incorporated in a filtered back-projection based maximum a posteriori (BHC-FMAP). In the proposed algorithm, the beam hardening effect is modeled and incorporated into the forward-projection of the MAP to suppress beam hardening induced artifacts, and the image update process is performed by Feldkamp–Davis–Kress method based back-projection to speed up the convergence. The proposed BHC-FMAP approach does not require information about the beam spectrum or the material properties, or any additional segmentation operation. The proposed method was qualitatively and quantitatively evaluated using both phantom and animal projection data. The experimental results demonstrate that the BHC-FMAP method can efficiently provide a good correction of beam hardening induced artefacts.
OCR Post-Processing Error Correction Algorithm using Google Online Spelling Suggestion
Bassil, Youssef
2012-01-01
With the advent of digital optical scanners, a lot of paper-based books, textbooks, magazines, articles, and documents are being transformed into an electronic version that can be manipulated by a computer. For this purpose, OCR, short for Optical Character Recognition was developed to translate scanned graphical text into editable computer text. Unfortunately, OCR is still imperfect as it occasionally mis-recognizes letters and falsely identifies scanned text, leading to misspellings and linguistics errors in the OCR output text. This paper proposes a post-processing context-based error correction algorithm for detecting and correcting OCR non-word and real-word errors. The proposed algorithm is based on Google's online spelling suggestion which harnesses an internal database containing a huge collection of terms and word sequences gathered from all over the web, convenient to suggest possible replacements for words that have been misspelled during the OCR process. Experiments carried out revealed a signific...
Ground target localization algorithm for semi-active laser terminal correction projectile
Xing-long Li
2016-06-01
Full Text Available A target localization algorithm, which uses the measurement information from onboard GPS and onboard laser detector to acquire the target position, is proposed to obtain the accurate position of ground target in real time in the trajectory correction process of semi-active laser terminal correction projectile. A target localization model is established according to projectile position, attitude and line-of-sight angle. The effects of measurement errors of projectile position, attitude and line-of-sight angle on localization accuracy at different quadrant elevation angles are analyzed through Monte-Carlo simulation. The simulation results show that the measurement error of line-of-sight angle has the largest influence on the localization accuracy. The localization accuracy decreases with the increase in quadrant elevation angle. However, the maximum localization accuracy is less than 7 m. The proposed algorithm meets the accuracy and real-time requirements of target localization.
Performance evaluation of operational atmospheric correction algorithms over the East China Seas
He, Shuangyan; He, Mingxia; Fischer, Jürgen
2017-01-01
To acquire high-quality operational data products for Chinese in-orbit and scheduled ocean color sensors, the performances of two operational atmospheric correction (AC) algorithms (ESA MEGS 7.4.1 and NASA SeaDAS 6.1) were evaluated over the East China Seas (ECS) using MERIS data. The spectral remote sensing reflectance R rs(λ), aerosol optical thickness (AOT), and Ångström exponent (α) retrieved using the two algorithms were validated using in situ measurements obtained between May 2002 and October 2009. Match-ups of R rs, AOT, and α between the in situ and MERIS data were obtained through strict exclusion criteria. Statistical analysis of R rs(λ) showed a mean percentage difference (MPD) of 9%-13% in the 490-560 nm spectral range, and significant overestimation was observed at 413 nm (MPD>72%). The AOTs were overestimated (MPD>32%), and although the ESA algorithm outperformed the NASA algorithm in the blue-green bands, the situation was reversed in the red-near-infrared bands. The value of α was obviously underestimated by the ESA algorithm (MPD=41%) but not by the NASA algorithm (MPD=35%). To clarify why the NASA algorithm performed better in the retrieval of α, scatter plots of the α single scattering albedo (SSA) density were prepared. These α-SSA density scatter plots showed that the applicability of the aerosol models used by the NASA algorithm over the ECS is better than that used by the ESA algorithm, although neither aerosol model is suitable for the ECS region. The results of this study provide a reference to both data users and data agencies regarding the use of operational data products and the investigation into the improvement of current AC schemes over the ECS.
Topology Correction of Segmented Medical Images using a Fast Marching Algorithm
2007-01-01
We present here a new method for correcting the topology of objects segmented from medical images. Whereas previous techniques alter a surface obtained from a binary segmentation of the object, our technique can be applied directly to the image intensities of a probabilistic or fuzzy segmentation, thereby propagating the topology for all isosurfaces of the object. From an analysis of topological changes and critical points in implicit surfaces, we derive a topology propagation algorithm that ...
An improved TES algorithm based on the corrected ALPHA difference spectrum
2007-01-01
Different from visible signals, thermal infrared radiances depend on both temperature and emissivity. It is a key problem for us to separate temperature and emissivity in thermal infrared remote sensing re- search. Another difficulty encountered in the retrieval of surface temperature is the correction of downwelling sky irradiance, because it is closely related to surface emissivity. When emissivity is un- known, the downwelling sky irradiance is difficult to be removed. In this paper, we introduce a correc- tion term of downwelling sky irradiance developed by Li and Becker into Wien’s approximation, to de- rive an improved ALPHA difference spectrum which is independent of temperature, and furthermore develop a correction term to remove the error of Wien’s approximation. Under the support of the above work, attractive features of Alpha derived emissivity method and ASTER TES algorithm are combined together to acquire a new Improved TES algorithm based on Corrected ALPHA Difference Spectrum (ICADS TES). Because a multi-band inversion technique is applied, and the operations of band ratios and differences are included in the algorithm, it can partly remove the influence of atmosphere and noises. Numerical simulation experiments show that for various combinations of atmosphere, land covers and surface temperatures, the algorithm is applicable and stable. Its accuracy for temperature is 0―1.5 K, and that for emissivity is 0―0.015. Compared with current TES algorithms, our method has clear physical meaning, is easy to be implemented, and is applicable for a wide temperature range and surface types. The results are not influenced by the directional characteristic of emissivity. Because ICADS TES does not need the support of a priori information of surface types, it is also not influenced by the accuracy of classification and the problem of mixture pixels. Compared with our former TES algorithm based on corrected Alpha difference spectra (CADS TES), the new
Luis Alberto Vieira de Carvalho
2007-12-01
Full Text Available O objetivo principal deste trabalho foi o desenvolvimento e a implementação de um algoritmo para simulação de cirurgias foto-refrativas. Sabe-se que os atuais " flying-spot" lasers para cirurgia refrativa disponíveis no mercado ainda contêm limitações na correção de algumas aberrações de ordem alta. No entanto, há muito pouca informação quantitativa sobre os erros envolvidos em função da complexidade das aberrações. Aplicando-se superfícies objetivo descritas por uma série de coeficientes de Zernike e o conceito matemático de convolução, várias ablações personalizadas foram simuladas para várias aberrações, desde baixa ordem (esfero-cilíndricas até aberrações de décima ordem (como coma, aberração esférica, entre outras. Os resultados mostram que o perfil de ablação de cada pulso do laser assim como seu diâmetro são fatores críticos quando o objetivo é corrigir aberrações de alta ordem. Além disso, outras conclusões foram possíveis, como por exemplo a de que nem todas as aberrações de alta ordem induzem aos mesmos erros na ablação. Também foi possível verificar que a correção de aberrações de alta ordem nos termos radiais (como aberração esférica é bem mais difícil do que naqueles termos contendo alta frequência angular (como trefoil.PURPOSE: To develop and implement an algorithm for simulation of photorefractive surgery. It is well known that many flying-spot lasers in the market have limitations in correcting higher order aberrations, but there is little quantitative information about errors related to aberration complexity. METHODS: By applying known surfaces described by Zernike polynomials of different orders it was possible to simulate several target surfaces that may well resemble in vivo cases of refractive surgery candidates. An algorithm that uses the mathematical concept of convolution was implemented and several simulated surfaces were tested, ranging from low order
Pinkevych, Mykola; Cromer, Deborah; Tolstrup, Martin
2016-01-01
[This corrects the article DOI: 10.1371/journal.ppat.1005000.][This corrects the article DOI: 10.1371/journal.ppat.1005740.][This corrects the article DOI: 10.1371/journal.ppat.1005679.].......[This corrects the article DOI: 10.1371/journal.ppat.1005000.][This corrects the article DOI: 10.1371/journal.ppat.1005740.][This corrects the article DOI: 10.1371/journal.ppat.1005679.]....
M. Collaud Coen
2010-04-01
Full Text Available The aerosol light absorption coefficient is an essential parameter involved in atmospheric radiation budget calculations. The Aethalometer (AE has the great advantage of measuring the aerosol light absorption coefficient at several wavelengths, but the derived absorption coefficients are systematically too high when compared to reference methods. Up to now, four different correction algorithms of the AE absorption coefficients have been proposed by several authors. A new correction scheme based on these previously published methods has been developed, which accounts for the optical properties of the aerosol particles embedded in the filter. All the corrections have been tested on six datasets representing different aerosol types and loadings and include multi-wavelength AE and white-light AE. All the corrections have also been evaluated through comparison with a Multi-Angle Absorption Photometer (MAAP for four datasets lasting between 6 months and five years. The modification of the wavelength dependence by the different corrections is analyzed in detail. The performances and the limits of all AE corrections are determined and recommendations are given.
Collaud Coen, M.; Weingartner, E.; Apituley, A.; Ceburnis, D.; Fierz-Schmidhauser, R.; Flentje, H.; Henzing, J. S.; Jennings, S. G.; Moerman, M.; Petzold, A.; Schmid, O.; Baltensperger, U.
2010-04-01
The aerosol light absorption coefficient is an essential parameter involved in atmospheric radiation budget calculations. The Aethalometer (AE) has the great advantage of measuring the aerosol light absorption coefficient at several wavelengths, but the derived absorption coefficients are systematically too high when compared to reference methods. Up to now, four different correction algorithms of the AE absorption coefficients have been proposed by several authors. A new correction scheme based on these previously published methods has been developed, which accounts for the optical properties of the aerosol particles embedded in the filter. All the corrections have been tested on six datasets representing different aerosol types and loadings and include multi-wavelength AE and white-light AE. All the corrections have also been evaluated through comparison with a Multi-Angle Absorption Photometer (MAAP) for four datasets lasting between 6 months and five years. The modification of the wavelength dependence by the different corrections is analyzed in detail. The performances and the limits of all AE corrections are determined and recommendations are given.
M. Collaud Coen
2009-07-01
Full Text Available The aerosol light absorption coefficient is an essential parameter involved in atmospheric radiation budget calculations. The Aethalometer (AE has the great advantage of measuring the aerosol light absorption coefficient at several wavelengths, but the derived absorption coefficients are systematically too high when compared to reference methods. Up to now, four different correction algorithms of the AE absorption coefficients have been proposed by several authors. A new correction scheme based on these previously published methods has been developed, which accounts for the optical properties of the aerosol particles embedded in the filter. All the corrections have been tested on six datasets representing different aerosol types and loadings and include multi-wavelength AE and white-light AE. All the corrections have also been evaluated through comparison with a Multi-Angle Absorption Photometer (MAAP for four datasets lasting between 6 months and five years. The modification of the wavelength dependence by the different corrections is analyzed in detail. The performances and the limits of all AE corrections are determined and recommendations are given.
LIAO HongLin; SHI HanSheng; SUN ZhiZhong
2009-01-01
Corrected explicit-implicit domain decomposition (CEIDD) algorithms are studied for parallel approximation of semilinear parabolic problems on distributed memory processors. It is natural to divide the spatial domain into some smaller parallel strips and cells using the simplest straight-line interface (SI). By using the Leray-Schauder fixed-point theorem and the discrete energy method, it is shown that the resulting CEIDD-SI algorithm is uniquely solvable, unconditionally stable and convergent. The CEIDD-SI method always suffers from the globalization of data communication when interior boundaries cross into each other inside the domain. To overcome this disadvantage, a composite interface (CI) that consists of straight segments and zigzag fractions is suggested. The corresponding CEIDD-CI algorithm is proven to be solvable, stable and convergent. Numerical experiments are presented to support the theoretical results.
SUI Jing; JIN Wei-qi; DONG Li-quan; WANG Xia; GUO Hong
2006-01-01
The improved scene-based adaptive nonuniformity correction (NUC) algorithms using a neural network (NNT) approach for infrared image sequences are presented and analyzed. The retina-like neural networks using steepest descent model was the first proposed infrared focal plane arrays (IRFPA) nonuniformity compensation method, which can perform parameter estimation of the sensors over time on a frame by frame basis. To increase the strength and the robustness of the NNT algorithm and to avoid the presence of ghosting artifacts, some optimization techniques, including momentum term,regularization factor and adaptive learning rate, were executed in the parameter learning process. In this paper, the local median filtering result of Xij ( n ) is proposed as an alternative value of desired network output of neuron Xij ( n ), denoted as Tij ( n ), which is the local spatial average of Xij ( n ) in traditional NNT methods. Noticeably, the NUC algorithm is inter-frame adaptive in nature and does not rely on any statistical assumptions on the scene data in the image sequence.Applications of this algorithm to the simulated video sequences and real infrared data taken with PV320 show that the correction results of image sequence are better than that of using original NNT approach, especially for the short-time image sequences (several hundred frames) subjected to the dense impulse noises with a number of dead or saturated pixels.
Tang, Y L; Zhu, Y L; Ma, X L
2016-01-01
Revealing strains on the unit-cell level is essential for understanding the particular performance of materials. Large-scale strain variations with a unit-cell resolution are important for studying ferroelectric materials since the spontaneous polarizations of such materials are strongly coupled with strains. Aberration-corrected high-angle-annular-dark-field scanning transmission electron microscopy (AC-HAADF-STEM) is not so sensitive to the sample thickness and therefore thickness gradients. Consequently it is extremely useful for large-scale strain determination, which can be readily extracted by geometrical phase analysis (GPA). Such a combination has various advantages: it is straightforward, accurate on the unit-cell scale, relatively insensitive to crystal orientation and therefore helpful for large-scale. We take a tetragonal ferroelectric PbTiO3 film as an example in which large-scale strains are determined. Furthermore, based on the specific relationship between lattice rotation and spontaneous polarization (Ps) at 180° domain-walls, the Ps directions are identified, which makes the investigation of ferroelectric domain structures accurate and straightforward. This method is proposed to be suitable for investigating strain-related phenomena in other ferroelectric materials.
Wu, HsinWei; Lu, Sirong; Aoki, Toshihiro; Ponath, Patrick; Ekerdt, John G.; Demkov, Alexander A.; McCartney, Martha R.; Smith, David J.
2017-06-01
The integration of semiconductors with ferroelectrics having a controlled polarization direction is an ongoing and challenging topic of research. In this work, BaTiO3 (BTO)/SrTiO3 (STO) heterostructures were grown by molecular beam epitaxy either directly with STO substrates or by using 2-nm-thick STO buffer layers on Ge(001) substrates. Sharp, chemically abrupt interfaces and c-axis-oriented BTO films for both types of heterostructures were observed using aberration-corrected scanning transmission electron microscopy and elemental mapping. Anti-phase boundaries as well as ⟨100⟩ misfit dislocations were present in the BTO/STO samples, with the offsets of the dislocation cores varying by distances between 1 and 5 nm away from the BTO/STO interface. Conversely, misfit dislocations were not observed in the BTO/STO/Ge structure although vertical anti-phase boundaries were still common. Overall, the results emphasize the benefits of identifying a suitable buffer layer to ensure the growth of a high quality material having the desired out-of-plane ferroelectric polarization.
C. Wen
2014-11-01
Full Text Available The stacking faults (SFs in an AlSb/GaAs (001 interface were investigated using a 300 kV spherical aberration-corrected high-resolution transmission electron microscope (HRTEM. The structure and strain distribution of the single and intersecting (V-shaped SFs associated with partial dislocations (PDs were characterized by the [110] HRTEM images and geometric phase analysis, respectively. In the biaxial strain maps εxx and εyy, a SF can be divided into several sections under different strain states (positive or negative strain values. Furthermore, the strain state for the same section of a SF is in contrast to each other in εxx and εyy strain maps. The modification in the strain states was attributed to the variation in the local atomic displacements for the SF in the AlSb film on the GaAs substrate recorded in the lattice image. Finally, the single SF was found to be bounded by two 30° PDs. A pair of 30° PDs near the heteroepitaxial interface reacted to form a Lomer-Cottrell sessile dislocation located at the vertices of V-shaped SFs with opposite screw components. The roles of misfit dislocations, such as the PDs, in strain relaxation were also discussed.
ECHO: a reference-free short-read error correction algorithm.
Kao, Wei-Chun; Chan, Andrew H; Song, Yun S
2011-07-01
Developing accurate, scalable algorithms to improve data quality is an important computational challenge associated with recent advances in high-throughput sequencing technology. In this study, a novel error-correction algorithm, called ECHO, is introduced for correcting base-call errors in short-reads, without the need of a reference genome. Unlike most previous methods, ECHO does not require the user to specify parameters of which optimal values are typically unknown a priori. ECHO automatically sets the parameters in the assumed model and estimates error characteristics specific to each sequencing run, while maintaining a running time that is within the range of practical use. ECHO is based on a probabilistic model and is able to assign a quality score to each corrected base. Furthermore, it explicitly models heterozygosity in diploid genomes and provides a reference-free method for detecting bases that originated from heterozygous sites. On both real and simulated data, ECHO is able to improve the accuracy of previous error-correction methods by several folds to an order of magnitude, depending on the sequence coverage depth and the position in the read. The improvement is most pronounced toward the end of the read, where previous methods become noticeably less effective. Using a whole-genome yeast data set, it is demonstrated here that ECHO is capable of coping with nonuniform coverage. Also, it is shown that using ECHO to perform error correction as a preprocessing step considerably facilitates de novo assembly, particularly in the case of low-to-moderate sequence coverage depth.
Quantitative (177)Lu SPECT imaging using advanced correction algorithms in non-reference geometry.
D'Arienzo, M; Cozzella, M L; Fazio, A; De Felice, P; Iaccarino, G; D'Andrea, M; Ungania, S; Cazzato, M; Schmidt, K; Kimiaei, S; Strigari, L
2016-12-01
Peptide receptor therapy with (177)Lu-labelled somatostatin analogues is a promising tool in the management of patients with inoperable or metastasized neuroendocrine tumours. The aim of this work was to perform accurate activity quantification of (177)Lu in complex anthropomorphic geometry using advanced correction algorithms. Acquisitions were performed on the higher (177)Lu photopeak (208keV) using a Philips IRIX gamma camera provided with medium-energy collimators. System calibration was performed using a 16mL Jaszczak sphere surrounded by non-radioactive water. Attenuation correction was performed using μ-maps derived from CT data, while scatter and septal penetration corrections were performed using the transmission-dependent convolution-subtraction method. SPECT acquisitions were finally corrected for dead time and partial volume effects. Image analysis was performed using the commercial QSPECT software. The quantitative SPECT approach was validated on an anthropomorphic phantom provided with a home-made insert simulating a hepatic lesion. Quantitative accuracy was studied using three tumour-to-background activity concentration ratios (6:1, 9:1, 14:1). For all acquisitions, the recovered total activity was within 12% of the calibrated activity both in the background region and in the tumour. Using a 6:1 tumour-to-background ratio the recovered total activity was within 2% in the tumour and within 5% in the background. Partial volume effects, if not properly accounted for, can lead to significant activity underestimations in clinical conditions. In conclusion, accurate activity quantification of (177)Lu can be obtained if activity measurements are performed with equipment traceable to primary standards, advanced correction algorithms are used and acquisitions are performed at the 208keV photopeak using medium-energy collimators.
A real-time misalignment correction algorithm for stereoscopic 3D cameras
Pekkucuksen, Ibrahim E.; Batur, Aziz Umit; Zhang, Buyue
2012-03-01
Camera calibration is an important problem for stereo 3-D cameras since the misalignment between the two views can lead to vertical disparities that significantly degrade 3-D viewing quality. Offline calibration during manufacturing is not always an option especially for mass produced cameras due to cost. In addition, even if one-time calibration is performed during manufacturing, its accuracy cannot be maintained indefinitely because environmental factors can lead to changes in camera hardware. In this paper, we propose a real-time stereo calibration solution that runs inside a consumer camera and continuously estimates and corrects for the misalignment between the stereo cameras. Our algorithm works by processing images of natural scenes and does not require the use of special calibration charts. The algorithm first estimates the disparity in horizontal and vertical directions between the corresponding blocks from stereo images. Then, this initial estimate is refined with two dimensional search using smaller sub-blocks. The displacement data and block coordinates are fed to a modified affine transformation model and outliers are discarded to keep the modeling error low. Finally, the estimated affine parameters are split by half and misalignment correction is applied to each view accordingly. The proposed algorithm significantly reduces the misalignment between stereo frames and enables a more comfortable 3-D viewing experience.
Pile-up correction by Genetic Algorithm and Artificial Neural Network
Kafaee, M.; Saramad, S.
2009-08-01
Pile-up distortion is a common problem for high counting rates radiation spectroscopy in many fields such as industrial, nuclear and medical applications. It is possible to reduce pulse pile-up using hardware-based pile-up rejections. However, this phenomenon may not be eliminated completely by this approach and the spectrum distortion caused by pile-up rejection can be increased as well. In addition, inaccurate correction or rejection of pile-up artifacts in applications such as energy dispersive X-ray (EDX) spectrometers can lead to losses of counts, will give poor quantitative results and even false element identification. Therefore, it is highly desirable to use software-based models to predict and correct any recognized pile-up signals in data acquisition systems. The present paper describes two new intelligent approaches for pile-up correction; the Genetic Algorithm (GA) and Artificial Neural Networks (ANNs). The validation and testing results of these new methods have been compared, which shows excellent agreement with the measured data with 60Co source and NaI detector. The Monte Carlo simulation of these new intelligent algorithms also shows their advantages over hardware-based pulse pile-up rejection methods.
Line end shortening and application of novel correction algorithms in e-beam direct write
Freitag, Martin; Choi, Kang-Hoon; Gutsch, Manuela; Hohle, Christoph
2011-03-01
For the manufacturing of semiconductor technologies following the ITRS roadmap, we will face the nodes well below 32nm half pitch in the next 2~3 years. Despite being able to achieve the required resolution, which is now possible with electron beam direct write variable shaped beam (EBDW VSB) equipment and resists, it becomes critical to precisely reproduce dense line space patterns onto a wafer. This exposed pattern must meet the targets from the layout in both dimensions (horizontally and vertically). For instance, the end of a line must be printed in its entire length to allow a later placed contact to be able to land on it. Up to now, the control of printed patterns such as line ends is achieved by a proximity effect correction (PEC) which is mostly based on a dose modulation. This investigation of the line end shortening (LES) includes multiple novel approaches, also containing an additional geometrical correction, to push the limits of the available data preparation algorithms and the measurement. The designed LES test patterns, which aim to characterize the status of LES in a quick and easy way, were exposed and measured at Fraunhofer Center Nanoelectronic Technologies (CNT) using its state of the art electron beam direct writer and CD-SEM. Simulation and exposure results with the novel LES correction algorithms applied to the test pattern and a large production like pattern in the range of our target CDs in dense line space features smaller than 40nm will be shown.
Artificial-neural-network-based atmospheric correction algorithm: application to MERIS data
Schroeder, Thomas; Fischer, Juergen; Schaale, Michael; Fell, Frank
2003-05-01
After the successful launch of the Medium Resolution Imaging Spectrometer (MERIS) on board of the European Space Agency (ESA) Environmental Satellite (ENVISAT) on March 1st 2002, first MERIS data are available for validation purposes. The primary goal of the MERIS mission is to measure the color of the sea with respect to oceanic biology and marine water quality. We present an atmospheric correction algorithm for case-I waters based on the inverse modeling of radiative transfer calculations by artificial neural networks. The proposed correction scheme accounts for multiple scattering and high concentrations of absorbing aerosols (e.g. desert dust). Above case-I waters, the measured near infrared path radiance at Top-Of-Atmosphere (TOA) is assumed to originate from atmospheric processes only and is used to determine the aerosol properties with the help of an additional classification test in the visible spectral region. A synthetic data set is generated from radiative transfer simulations and is subsequently used to train different Multi-Layer-Perceptrons (MLP). The atmospheric correction scheme consists of two steps. First a set of MLPs is used to derive the aerosol optical thickness (AOT) and the aerosol type for each pixel. Second these quantities are fed into a further MLP trained with simulated data for various chlorophyll concentrations to perform the radiative transfer inversion and to obtain the water-leaving radiance. In this work we apply the inversion algorithm to a MERIS Level 1b data track covering the Indian Ocean along the west coast of Madagascar.
Holographically Correcting Synthetic Aperture Aberrations.
1987-12-01
Malacara (20:105-148). The synthetic aperture was aligned in accordance with the synthetic-aperture alignment technique of Gill (8:61-64). The...1987. 20. Malacara , Daniel, ed. Optical Shop Testing. New York: John Wiley & Sons, 1978. 21. Marciniak, Capt Michael. Tutorial Presentation of mV
A passive synthetic aperture phase correction algorithm for the asymmetric twin-line array sonar
无
2007-01-01
A passive synthetic aperture based on phase correction algorithm for solving the port-starboard discrimination problem in the non-aligned towed twin-line array sonar, is described. This method creates a virtual array through applying the estimated phase correction into one array of twin-line arrays. Because the synthetic virtual array is aligned with the other array in twin-line arrays, the right port-starboard discriminated results can be obtained by array processing based on the new synthetic twin-line array. The effect of proposed method has been shown by simulated and sea-trials results in towed twin-line array sonar. With low extra computational loads, the proposed method is easy to apply to the practice.
Romanov, A.; Edstrom, D.; Emanov, F. A.; Koop, I. A.; Perevedentsev, E. A.; Rogovsky, Yu. A.; Shwartz, D. B.; Valishev, A.
2017-03-28
Precise beam based measurement and correction of magnetic optics is essential for the successful operation of accelerators. The LOCO algorithm is a proven and reliable tool, which in some situations can be improved by using a broader class of experimental data. The standard data sets for LOCO include the closed orbit responses to dipole corrector variation, dispersion, and betatron tunes. This paper discusses the benefits from augmenting the data with four additional classes of experimental data: the beam shape measured with beam profile monitors; responses of closed orbit bumps to focusing field variations; betatron tune responses to focusing field variations; BPM-to-BPM betatron phase advances and beta functions in BPMs from turn-by-turn coordinates of kicked beam. All of the described features were implemented in the Sixdsimulation software that was used to correct the optics of the VEPP-2000 collider, the VEPP-5 injector booster ring, and the FAST linac.
Parallel Implementation of Bias Field Correction Fuzzy C-Means Algorithm for Image Segmentation
Nouredine AITALI
2016-03-01
Full Text Available Image segmentation in the medical field is one of the most important phases to diseases diagnosis. The bias field estimation algorithm is the most interesting techniques to correct the in-homogeneity intensity artifact on the image. However, the use of such technique requires a powerful processing and quite expensive for big size as medical images. Hence the idea of parallelism becomes increasingly required. Several researchers have followed this path mainly in the bioinformatics field where they have suggested different algorithms implementations. In this paper, a novel Single Instruction Multiple Data (SIMD architecture for bias field estimation and image segmentation algorithm is proposed. In order to accelerate compute-intensive portions of the sequential implementation, we have implemented this algorithm on three different graphics processing units (GPU cards named GT740m, GTX760 and GTX580 respectively, using Compute Unified Device Architecture (CUDA software programming tool. Numerical obtained results for the computation speed up, allowed us to conclude on the suitable GPU architecture for this kind of applications and closest ones.
Parallel algorithms of relative radiometric correction for images of TH-1 satellite
Wang, Xiang; Zhang, Tingtao; Cheng, Jiasheng; Yang, Tao
2014-05-01
The first generation of transitive stereo-metric satellites in China, TH-1 Satellite, is able to gain stereo images of three-line-array with resolution of 5 meters, multispectral images of 10 meters, and panchromatic high resolution images of 2 meters. The procedure between level 0 and level 1A of high resolution images is so called relative radiometric correction (RRC for short). The processing algorithm of high resolution images, with large volumes of data, is complicated and time consuming. In order to bring up the processing speed, people in industry commonly apply parallel processing techniques based on CPU or GPU. This article firstly introduces the whole process and each step of the algorithm - that is in application - of RRC for high resolution images in level 0; secondly, the theory and characteristics of MPI (Message Passing Interface) and OpenMP (Open Multi-Processing) parallel programming techniques is briefly described, as well as the superiority for parallel technique in image processing field; thirdly, aiming at each step of the algorithm in application and based on MPI+OpenMP hybrid paradigm, the parallelizability and the strategies of parallelism for three processing steps: Radiometric Correction, Splicing Pieces of TDICCD (Time Delay Integration Charge-Coupled Device) and Gray Level Adjustment among pieces of TDICCD are deeply discussed, and furthermore, deducts the theoretical acceleration rates of each step and the one of whole procedure, according to the processing styles and independence of calculation; for the step Splicing Pieces of TDICCD, two different strategies of parallelism are proposed, which are to be chosen with consideration of hardware capabilities; finally, series of experiments are carried out to verify the parallel algorithms by applying 2-meter panchromatic high resolution images of TH-1 Satellite, and the experimental results are analyzed. Strictly on the basis of former parallel algorithms, the programs in the experiments
Marco eGanzetti; Nicole eWenderoth; Dante eMantini
2016-01-01
Intensity non-uniformity (INU) in magnetic resonance (MR) imaging is a major issue when conducting analyses of brain structural properties. An inaccurate INU correction may result in qualitative and quantitative misinterpretations. Several INU correction methods exist, whose performance largely depend on the specific parameter settings that need to be chosen by the user. Here we addressed the question of how to select the best input parameters for a specific INU correction algorithm. Our inve...
Stanke, Monika; Palikot, Ewa; Adamowicz, Ludwik
2016-05-01
Algorithms for calculating the leading mass-velocity (MV) and Darwin (D) relativistic corrections are derived for electronic wave functions expanded in terms of n-electron explicitly correlated Gaussian functions with shifted centers and without pre-exponential angular factors. The algorithms are implemented and tested in calculations of MV and D corrections for several points on the ground-state potential energy curves of the H2 and LiH molecules. The algorithms are general and can be applied in calculations of systems with an arbitrary number of electrons.
Kanematsu, Nobuyuki
2011-04-01
This work addresses computing techniques for dose calculations in treatment planning with proton and ion beams, based on an efficient kernel-convolution method referred to as grid-dose spreading (GDS) and accurate heterogeneity-correction method referred to as Gaussian beam splitting. The original GDS algorithm suffered from distortion of dose distribution for beams tilted with respect to the dose-grid axes. Use of intermediate grids normal to the beam field has solved the beam-tilting distortion. Interplay of arrangement between beams and grids was found as another intrinsic source of artifact. Inclusion of rectangular-kernel convolution in beam transport, to share the beam contribution among the nearest grids in a regulatory manner, has solved the interplay problem. This algorithmic framework was applied to a tilted proton pencil beam and a broad carbon-ion beam. In these cases, while the elementary pencil beams individually split into several tens, the calculation time increased only by several times with the GDS algorithm. The GDS and beam-splitting methods will complementarily enable accurate and efficient dose calculations for radiotherapy with protons and ions. Copyright © 2010 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
Z. X. Cao
2014-06-01
Full Text Available To retrieve complex-valued effective permittivity and permeability of electromagnetic metamaterials (EMMs based on resonant effect from scattering parameters using a complex logarithmic function is not inevitable. When complex values are expressed in terms of magnitude and phase, an infinite number of permissible phase angles is permissible due to the multi-valued property of complex logarithmic functions. Special attention needs to be paid to ensure continuity of the effective permittivity and permeability of lossy metamaterials as frequency sweeps. In this paper, an automated phase correction (APC algorithm is proposed to properly trace and compensate phase angles of the complex logarithmic function which may experience abrupt phase jumps near the resonant frequency region of the concerned EMMs, and hence the continuity of the effective optical properties of lossy metamaterials is ensured. The algorithm is then verified to extract effective optical properties from the simulated scattering parameters of the four different types of metamaterial media: a cut-wire cell array, a split ring resonator (SRR cell array, an electric-LC (E-LC resonator cell array, and a combined SRR and wire cell array respectively. The results demonstrate that the proposed algorithm is highly accurate and effective.
Bernau, Christoph; Augustin, Thomas; Boulesteix, Anne-Laure
2013-09-01
High-dimensional binary classification tasks, for example, the classification of microarray samples into normal and cancer tissues, usually involve a tuning parameter. By reporting the performance of the best tuning parameter value only, over-optimistic prediction errors are obtained. For correcting this tuning bias, we develop a new method which is based on a decomposition of the unconditional error rate involving the tuning procedure, that is, we estimate the error rate of wrapper algorithms as introduced in the context of internal cross-validation (ICV) by Varma and Simon (2006, BMC Bioinformatics 7, 91). Our subsampling-based estimator can be written as a weighted mean of the errors obtained using the different tuning parameter values, and thus can be interpreted as a smooth version of ICV, which is the standard approach for avoiding tuning bias. In contrast to ICV, our method guarantees intuitive bounds for the corrected error. Additionally, we suggest to use bias correction methods also to address the conceptually similar method selection bias that results from the optimal choice of the classification method itself when evaluating several methods successively. We demonstrate the performance of our method on microarray and simulated data and compare it to ICV. This study suggests that our approach yields competitive estimates at a much lower computational price.
Kubendran, Rajkumar; Lee, Seulki; Mitra, Srinjoy; Yazicioglu, Refet Firat
2014-04-01
Implantable and ambulatory measurement of physiological signals such as Bio-impedance using miniature biomedical devices needs careful tradeoff between limited power budget, measurement accuracy and complexity of implementation. This paper addresses this tradeoff through an extensive analysis of different stimulation and demodulation techniques for accurate Bio-impedance measurement. Three cases are considered for rigorous analysis of a generic impedance model, with multiple poles, which is stimulated using a square/sinusoidal current and demodulated using square/sinusoidal clock. For each case, the error in determining pole parameters (resistance and capacitance) is derived and compared. An error correction algorithm is proposed for square wave demodulation which reduces the peak estimation error from 9.3% to 1.3% for a simple tissue model. Simulation results in Matlab using ideal RC values show an average accuracy of for single pole and for two pole RC networks. Measurements using ideal components for a single pole model gives an overall and readings from saline phantom solution (primarily resistive) gives an . A Figure of Merit is derived based on ability to accurately resolve multiple poles in unknown impedance with minimal measurement points per decade, for given frequency range and supply current budget. This analysis is used to arrive at an optimal tradeoff between accuracy and power. Results indicate that the algorithm is generic and can be used for any application that involves resolving poles of an unknown impedance. It can be implemented as a post-processing technique for error correction or even incorporated into wearable signal monitoring ICs.
A Modified Fuzzy C-Means Algorithm for Brain MR Image Segmentation and Bias Field Correction
Wen-Qian Deng; Xue-Mei Li; Xifeng Gao; Cai-Ming Zhang
2016-01-01
In quantitative brain image analysis, accurate brain tissue segmentation from brain magnetic resonance image (MRI) is a critical step. It is considered to be the most important and diﬃcult issue in the field of medical image processing. The quality of MR images is influenced by partial volume effect, noise, and intensity inhomogeneity, which render the segmentation task extremely challenging. We present a novel fuzzy c-means algorithm (RCLFCM) for segmentation and bias field correction of brain MR images. We employ a new gray-difference coeﬃcient and design a new impact factor to measure the effect of neighbor pixels, so that the robustness of anti-noise can be enhanced. Moreover, we redefine the objective function of FCM (fuzzy c-means) by adding the bias field estimation model to overcome the intensity inhomogeneity in the image and segment the brain MR images simultaneously. We also construct a new spatial function by combining pixel gray value dissimilarity with its membership, and make full use of the space information between pixels to update the membership. Compared with other state-of-the-art approaches by using similarity accuracy on synthetic MR images with different levels of noise and intensity inhomogeneity, the proposed algorithm generates the results with high accuracy and robustness to noise.
A novel image-based motion correction algorithm on ultrasonic image
Wang, Xuan; Li, Yaqin; Li, Shigao
2015-12-01
Lung respiratory movement can cause errors in the operation of image navigation surgery and they are the main errors in the navigation system. To solve this problem, the image-based motion correction strategy should be proposed to quickly correct the respiratory motion in the image sequence. So, the commercial ultrasound machine can display contrast and tissue images simultaneously. In the paper, a convenient, simple and easy-to-use breathing model whose precision was close to the sub-voxel was proposed. The first, in the clinical case the low gray-level variation in the tissue images, motion parameters were first calculated according to the actual lung movement information of each point the tissue images are registered by using template matching with sum of absolute differences metric. Finally, the similar images are selected by a double-selection method which requires global and local threshold setting. The generic breathing model was constructed based on all the sample data. The results of experiments show the algorithm can reduce the original errors caused by breath movement heavily.
A method of generalized projections (MGP) ghost correction algorithm for interleaved EPI.
Lee, K J; Papadakis, N G; Barber, D C; Wilkinson, I D; Griffiths, P D; Paley, M N J
2004-07-01
Investigations into the method of generalized projections (MGP) as a ghost correction method for interleaved EPI are described. The technique is image-based and does not require additional reference scans. The algorithm was found to be more effective if a priori knowledge was incorporated to reduce the degrees of freedom, by modeling the ghosting as arising from a small number of phase offsets. In simulations with phase variation between consecutive shots for n-interleaved echo planar imaging (EPI), ghost reduction was achieved for n = 2 only. With no phase variation between shots, ghost reduction was obtained with n up to 16. Incorporating a relaxation parameter was found to improve convergence. Dependence of convergence on the region of support was also investigated. A fully automatic version of the method was developed, using results from the simulations. When tested on in vivo 2-, 16-, and 32-interleaved spin-echo EPI data, the method achieved deghosting and image restoration close to that obtained by both reference scan and odd/even filter correction, although some residual artifacts remained.
Marco eGanzetti
2016-03-01
Full Text Available Intensity non-uniformity (INU in magnetic resonance (MR imaging is a major issue when conducting analyses of brain structural properties. An inaccurate INU correction may result in qualitative and quantitative misinterpretations. Several INU correction methods exist, whose performance largely depend on the specific parameter settings that need to be chosen by the user. Here we addressed the question of how to select the best input parameters for a specific INU correction algorithm. Our investigation was based on the INU correction algorithm implemented in SPM, but this can be in principle extended to any other algorithm requiring the selection of input parameters. We conducted a comprehensive comparison of indirect metrics for the assessment of INU correction performance, namely the coefficient of variation of white matter (CV_WM, the coefficient of variation of gray matter (CV_GM, and the coefficient of joint variation between white matter and gray matter (CJV. Using simulated MR data, we observed the CJV to be more accurate than CV_WM and CV_GM, provided that the noise level in the INU-corrected image was controlled by means of spatial smoothing. Based on the CJV, we developed a data-driven approach for selecting INU correction parameters, which could effectively work on actual MR images. To this end, we implemented an enhanced procedure for the definition of white and gray matter masks, based on which the CJV was calculated. Our approach was validated using actual T1-weighted images collected with 1.5 T, 3 T and 7 T MR scanners. We found that our procedure can reliably assist the selection of valid INU correction algorithm parameters, thereby contributing to an enhanced inhomogeneity correction in MR images.
Ganzetti, Marco; Wenderoth, Nicole; Mantini, Dante
2016-01-01
Intensity non-uniformity (INU) in magnetic resonance (MR) imaging is a major issue when conducting analyses of brain structural properties. An inaccurate INU correction may result in qualitative and quantitative misinterpretations. Several INU correction methods exist, whose performance largely depend on the specific parameter settings that need to be chosen by the user. Here we addressed the question of how to select the best input parameters for a specific INU correction algorithm. Our investigation was based on the INU correction algorithm implemented in SPM, but this can be in principle extended to any other algorithm requiring the selection of input parameters. We conducted a comprehensive comparison of indirect metrics for the assessment of INU correction performance, namely the coefficient of variation of white matter (CVWM), the coefficient of variation of gray matter (CVGM), and the coefficient of joint variation between white matter and gray matter (CJV). Using simulated MR data, we observed the CJV to be more accurate than CVWM and CVGM, provided that the noise level in the INU-corrected image was controlled by means of spatial smoothing. Based on the CJV, we developed a data-driven approach for selecting INU correction parameters, which could effectively work on actual MR images. To this end, we implemented an enhanced procedure for the definition of white and gray matter masks, based on which the CJV was calculated. Our approach was validated using actual T1-weighted images collected with 1.5 T, 3 T, and 7 T MR scanners. We found that our procedure can reliably assist the selection of valid INU correction algorithm parameters, thereby contributing to an enhanced inhomogeneity correction in MR images.
Image aberrations in optical three-dimensional measurement systems with fringe projection.
Brakhage, Peter; Notni, Gunther; Kowarschik, Richard
2004-06-01
In optical shape measurement systems, systematic errors appear as a result of imaging aberrations of the lens assemblies in the cameras and projectors. A mathematical description of this effect is intended to correct the whole measurement area with a few independent coefficients. We apply the ideas of photogrammetry to one- and two-dimensional fringe projection techniques. We also introduce some new terms for close-range applications and telecentric objectives. Further, an algorithm for distance-dependent corrections is introduced. Also, we describe a new method with which to determine coefficients of aberration with an optimization-based method.
C. R. Bharathi
2012-01-01
Full Text Available Problem statement: In real-world environment, speech signal processing plays a vital role among the research communities. A wide range of researches are carried out in this field for denoising, enhancement and more. Besides the other, stress management is important to identify the spot in which the stress has to be made. Approach: In this study, in order to provide proper speech practice for the abnormal person, their speech is analyzed. Initially, the normal and abnormal personâs speech are obtained with the same set of words. As an initial process, the Mel Frequency Cepstrum Coefficients (MFCC is extracted from both words and the Principal Component Analysis (PCA is applied to reduce the dimensionality of the words. From the dimensionality reduced words, the parameters are obtained and then these parameters are utilized to train the ANN which is used to identify the word that is abnormal. After identifying the abnormal word, the acute word is extracted through the thresholding operation and then FFT is computed for the acute word. From this FFT, the parameters are obtained and then these parameters are used in the genetic algorithm for optimization. GA is used to identify the spot in which the speech practice is required for the abnormal person. Results: The proposed system is implemented in the working platform of MATLAB. The performance of the proposed system is tested by generating the dataset for the normal and abnormal female children. Conclusion: In this study, an effective system has been proposed to identify the abnormal word and the spot in which the speech has to be improved also identified.
Geo-correction Algorithm Based on Equivalent RD Model for ScanSAR of HJ-1-C Satellite
Liu Jia-yin
2014-06-01
Full Text Available HJ-1-C satellite is the first Synthetic Aperture Radar (SAR satellite for civilian use in China, and it has a strip and scan mode. According to the characteristics of the ScanSAR of the HJ-1-C satellite, a geo-correction algorithm based on an equivalent RD model has been outlined in this paper on the basis of an ECS image processing algorithm and a traditional Range-Doppler location method. An azimuth mosaic was presented by a time series relationship, then the different burst was stitched by range, and the equivalent parameters were fitted to locations on the RD model. Finally, the ScanSAR image was geo-corrected. The HJ-1-C satellite data results showed that the location accuracy of ScanSAR for the HJ-1-C satellite was less than 100 m, and the geo-correction algorithm was realized in 10 s in fewer than 24 parallel cores.
Cao, Ye [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Tang, Xiao-Bin, E-mail: tangxiaobin@nuaa.edu.cn [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Jiangsu Key Laboratory of Nuclear Energy Equipment Materials Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Wang, Peng; Meng, Jia; Huang, Xi; Wen, Liang-Sheng [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Chen, Da [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Jiangsu Key Laboratory of Nuclear Energy Equipment Materials Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China)
2015-10-11
The unmanned aerial vehicle (UAV) radiation monitoring method plays an important role in nuclear accidents emergency. In this research, a spectrum correction algorithm about the UAV airborne radioactivity monitoring equipment NH-UAV was studied to measure the radioactive nuclides within a small area in real time and in a fixed place. The simulation spectra of the high-purity germanium (HPGe) detector and the lanthanum bromide (LaBr{sub 3}) detector in the equipment were obtained using the Monte Carlo technique. Spectrum correction coefficients were calculated after performing ratio processing techniques about the net peak areas between the double detectors on the detection spectrum of the LaBr{sub 3} detector according to the accuracy of the detection spectrum of the HPGe detector. The relationship between the spectrum correction coefficient and the size of the source term was also investigated. A good linear relation exists between the spectrum correction coefficient and the corresponding energy (R{sup 2}=0.9765). The maximum relative deviation from the real condition reduced from 1.65 to 0.035. The spectrum correction method was verified as feasible. - Highlights: • An airborne radioactivity monitoring equipment NH-UAV was developed to measure radionuclide after a nuclear accident. • A spectrum correction algorithm was proposed to obtain precise information on the detected radioactivity within a small area. • The spectrum correction method was verified as feasible. • The corresponding spectrum correction coefficients increase first and then stay constant.
Ma, Xingkun; Huang, Lei; Bian, Qi; Gong, Mali
2014-09-10
The wavefront correction ability of a deformable mirror with a multireflection waveguide was investigated and compared via simulations. By dividing a conventional actuator array into a multireflection waveguide that consisted of single-actuator units, an arbitrary actuator pattern could be achieved. A stochastic parallel perturbation algorithm was proposed to find the optimal actuator pattern for a particular aberration. Compared with conventional an actuator array, the multireflection waveguide showed significant advantages in correction of higher order aberrations.
2002-01-01
Tile Calorimeter modules stored at CERN. The larger modules belong to the Barrel, whereas the smaller ones are for the two Extended Barrels. (The article was about the completion of the 64 modules for one of the latter.) The photo on the first page of the Bulletin n°26/2002, from 24 July 2002, illustrating the article «The ATLAS Tile Calorimeter gets into shape» was published with a wrong caption. We would like to apologise for this mistake and so publish it again with the correct caption.
Lohmann, Christoph; Kuzmin, Dmitri; Shadid, John N.; Mabuza, Sibusiso
2017-09-01
This work extends the flux-corrected transport (FCT) methodology to arbitrary order continuous finite element discretizations of scalar conservation laws on simplex meshes. Using Bernstein polynomials as local basis functions, we constrain the total variation of the numerical solution by imposing local discrete maximum principles on the Bézier net. The design of accuracy-preserving FCT schemes for high order Bernstein-Bézier finite elements requires the development of new algorithms and/or generalization of limiting techniques tailored for linear and multilinear Lagrange elements. In this paper, we propose (i) a new discrete upwinding strategy leading to local extremum bounded low order approximations with compact stencils, (ii) high order variational stabilization based on the difference between two gradient approximations, and (iii) new localized limiting techniques for antidiffusive element contributions. The optional use of a smoothness indicator, based on a second derivative test, makes it possible to potentially avoid unnecessary limiting at smooth extrema and achieve optimal convergence rates for problems with smooth solutions. The accuracy of the proposed schemes is assessed in numerical studies for the linear transport equation in 1D and 2D.
Labaria, George R. [Univ. of California, Santa Cruz, CA (United States); Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Warrick, Abbie L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Celliers, Peter M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kalantar, Daniel H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
2015-01-12
The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory is a 192-beam pulsed laser system for high-energy-density physics experiments. Sophisticated diagnostics have been designed around key performance metrics to achieve ignition. The Velocity Interferometer System for Any Reflector (VISAR) is the primary diagnostic for measuring the timing of shocks induced into an ignition capsule. The VISAR system utilizes three streak cameras; these streak cameras are inherently nonlinear and require warp corrections to remove these nonlinear effects. A detailed calibration procedure has been developed with National Security Technologies (NSTec) and applied to the camera correction analysis in production. However, the camera nonlinearities drift over time, affecting the performance of this method. An in-situ fiber array is used to inject a comb of pulses to generate a calibration correction in order to meet the timing accuracy requirements of VISAR. We develop a robust algorithm for the analysis of the comb calibration images to generate the warp correction that is then applied to the data images. Our algorithm utilizes the method of thin-plate splines (TPS) to model the complex nonlinear distortions in the streak camera data. In this paper, we focus on the theory and implementation of the TPS warp-correction algorithm for the use in a production environment.
2002-01-01
The photo on the second page of the Bulletin n°48/2002, from 25 November 2002, illustrating the article «Spanish Visit to CERN» was published with a wrong caption. We would like to apologise for this mistake and so publish it again with the correct caption. The Spanish delegation, accompanied by Spanish scientists at CERN, also visited the LHC superconducting magnet test hall (photo). From left to right: Felix Rodriguez Mateos of CERN LHC Division, Josep Piqué i Camps, Spanish Minister of Science and Technology, César Dopazo, Director-General of CIEMAT (Spanish Research Centre for Energy, Environment and Technology), Juan Antonio Rubio, ETT Division Leader at CERN, Manuel Aguilar-Benitez, Spanish Delegate to Council, Manuel Delfino, IT Division Leader at CERN, and Gonzalo León, Secretary-General of Scientific Policy to the Minister.
2012-01-01
Full Text Available Regarding Gorelik, G., & Shackelford, T.K. (2011. Human sexual conflict from molecules to culture. Evolutionary Psychology, 9, 564–587: The authors wish to correct an omission in citation to the existing literature. In the final paragraph on p. 570, we neglected to cite Burch and Gallup (2006 [Burch, R. L., & Gallup, G. G., Jr. (2006. The psychobiology of human semen. In S. M. Platek & T. K. Shackelford (Eds., Female infidelity and paternal uncertainty (pp. 141–172. New York: Cambridge University Press.]. Burch and Gallup (2006 reviewed the relevant literature on FSH and LH discussed in this paragraph, and should have been cited accordingly. In addition, Burch and Gallup (2006 should have been cited as the originators of the hypothesis regarding the role of FSH and LH in the semen of rapists. The authors apologize for this oversight.
2014-01-01
Full Text Available Regarding Tagler, M. J., and Jeffers, H. M. (2013. Sex differences in attitudes toward partner infidelity. Evolutionary Psychology, 11, 821–832: The authors wish to correct values in the originally published manuscript. Specifically, incorrect 95% confidence intervals around the Cohen's d values were reported on page 826 of the manuscript where we reported the within-sex simple effects for the significant Participant Sex × Infidelity Type interaction (first paragraph, and for attitudes toward partner infidelity (second paragraph. Corrected values are presented in bold below. The authors would like to thank Dr. Bernard Beins at Ithaca College for bringing these errors to our attention. Men rated sexual infidelity significantly more distressing (M = 4.69, SD = 0.74 than they rated emotional infidelity (M = 4.32, SD = 0.92, F(1, 322 = 23.96, p < .001, d = 0.44, 95% CI [0.23, 0.65], but there was little difference between women's ratings of sexual (M = 4.80, SD = 0.48 and emotional infidelity (M = 4.76, SD = 0.57, F(1, 322 = 0.48, p = .29, d = 0.08, 95% CI [−0.10, 0.26]. As expected, men rated sexual infidelity (M = 1.44, SD = 0.70 more negatively than they rated emotional infidelity (M = 2.66, SD = 1.37, F(1, 322 = 120.00, p < .001, d = 1.12, 95% CI [0.85, 1.39]. Although women also rated sexual infidelity (M = 1.40, SD = 0.62 more negatively than they rated emotional infidelity (M = 2.09, SD = 1.10, this difference was not as large and thus in the evolutionary theory supportive direction, F(1, 322 = 72.03, p < .001, d = 0.77, 95% CI [0.60, 0.94].
无
2008-01-01
Based on digital signal processor(DSP) and field programmable gate array(FPGA) techniques, the architecture of super large view field(SLVF) panoramic night vision image processing hardware platform was established. The panoramic unwrapping and correcting algorithm, up to a full 360°, based on coordinate rotation digital computer (CORDIC) and night vision image enhancement algorithm, based on histogram equalization theory and edge detection theory, was presented in this paper, with the purpose of processing night vision dynamic panoramic annular image. The annular image can be unwrapped and corrected to conventional rectangular panorama by the panoramic image processing algorithm, which uses the pipelined CORDIC configuration to realize a trigonometric function generator with high speed and high precision. Histogram equalization algorithm can perfectly enhance the contrast of the night vision image. Edge detection algorithm can be propitious to find and detect small dim dynamic targets in night vision circumstances. After abundant experiment, the algorithm for panoramic image processing and night vision image enhancement is successfully implemented in FPGA and DSP. The panoramic night vision image system is a compact device, with no external rotating parts. And the system can reliably and dynamically detect 360° SLVF panoramic night vision image.
Optical Aberrations and Wavefront
Nihat Polat
2014-08-01
Full Text Available The deviation of light to create normal retinal image in the optical system is called aberration. Aberrations are divided two subgroup: low-order aberrations (defocus: spherical and cylindrical refractive errors and high-order aberrations (coma, spherical, trefoil, tetrafoil, quadrifoil, pentafoil, secondary astigmatism. Aberrations increase with aging. Spherical aberrations are compensated by positive corneal and negative lenticular spherical aberrations in youth. Total aberrations are elevated by positive corneal and positive lenticular spherical aberrations in elderly. In this study, we aimed to analyze the basic terms regarding optic aberrations which have gained significance recently. (Turk J Ophthalmol 2014; 44: 306-11
2015-10-01
In the article by Quintavalle et al (Quintavalle C, Anselmi CV, De Micco F, Roscigno G, Visconti G, Golia B, Focaccio A, Ricciardelli B, Perna E, Papa L, Donnarumma E, Condorelli G, Briguori C. Neutrophil gelatinase–associated lipocalin and contrast-induced acute kidney injury. Circ Cardiovasc Interv. 2015;8:e002673. DOI: 10.1161/CIRCINTERVENTIONS.115.002673.), which published online September 2, 2015, and appears in the September 2015 issue of the journal, a correction was needed. On page 1, the institutional affiliation for Elvira Donnarumma, PhD, “SDN Foundation,” has been changed to read, “IRCCS SDN, Naples, Italy.” The institutional affiliation for Laura Papa, PhD, “Institute for Endocrinology and Experimental Oncology, National Research Council, Naples, Italy,” has been changed to read, “Institute of Genetics and Biomedical Research, Milan Unit, Milan, Italy” and “Humanitas Research Hospital, Rozzano, Italy.” The authors regret this error.
Rani Sharma, Anu; Kharol, Shailesh Kumar; Kvs, Badarinath; Roy, P. S.
In Earth observation, the atmosphere has a non-negligible influence on the visible and infrared radiation which is strong enough to modify the reflected electromagnetic signal and at-target reflectance. Scattering of solar irradiance by atmospheric molecules and aerosol generates path radiance, which increases the apparent surface reflectance over dark surfaces while absorption by aerosols and other molecules in the atmosphere causes loss of brightness to the scene, as recorded by the satellite sensor. In order to derive precise surface reflectance from satellite image data, it is indispensable to apply the atmospheric correction which serves to remove the effects of molecular and aerosol scattering. In the present study, we have implemented a fast atmospheric correction algorithm to IRS-P6 AWiFS satellite data which can effectively retrieve surface reflectance under different atmospheric and surface conditions. The algorithm is based on MODIS climatology products and simplified use of Second Simulation of Satellite Signal in Solar Spectrum (6S) radiative transfer code, which is used to generate look-up-tables (LUTs). The algorithm requires information on aerosol optical depth for correcting the satellite dataset. The proposed method is simple and easy to implement for estimating surface reflectance from the at sensor recorded signal, on a per pixel basis. The atmospheric correction algorithm has been tested for different IRS-P6 AWiFS False color composites (FCC) covering the ICRISAT Farm, Patancheru, Hyderabad, India under varying atmospheric conditions. Ground measurements of surface reflectance representing different land use/land cover, i.e., Red soil, Chick Pea crop, Groundnut crop and Pigeon Pea crop were conducted to validate the algorithm and found a very good match between surface reflectance and atmospherically corrected reflectance for all spectral bands. Further, we aggregated all datasets together and compared the retrieved AWiFS reflectance with
Sheng-Hui, Rong; Hui-Xin, Zhou; Han-Lin, Qin; Rui, Lai; Kun, Qian
2016-05-01
Imaging non-uniformity of infrared focal plane array (IRFPA) behaves as fixed-pattern noise superimposed on the image, which affects the imaging quality of infrared system seriously. In scene-based non-uniformity correction methods, the drawbacks of ghosting artifacts and image blurring affect the sensitivity of the IRFPA imaging system seriously and decrease the image quality visibly. This paper proposes an improved neural network non-uniformity correction method with adaptive learning rate. On the one hand, using guided filter, the proposed algorithm decreases the effect of ghosting artifacts. On the other hand, due to the inappropriate learning rate is the main reason of image blurring, the proposed algorithm utilizes an adaptive learning rate with a temporal domain factor to eliminate the effect of image blurring. In short, the proposed algorithm combines the merits of the guided filter and the adaptive learning rate. Several real and simulated infrared image sequences are utilized to verify the performance of the proposed algorithm. The experiment results indicate that the proposed algorithm can not only reduce the non-uniformity with less ghosting artifacts but also overcome the problems of image blurring in static areas.
Maj, P.
2014-07-01
An important trend in the design of readout electronics working in the single photon counting mode for hybrid pixel detectors is to minimize the single pixel area without sacrificing its functionality. This is the reason why many digital and analog blocks are made with the smallest, or next to smallest, transistors possible. This causes a problem with matching among the whole pixel matrix which is acceptable by designers and, of course, it should be corrected with the use of dedicated circuitry, which, by the same rule of minimizing devices, suffers from the mismatch. Therefore, the output of such a correction circuit, controlled by an ultra-small area DAC, is not only a non-linear function, but it is also often non-monotonic. As long as it can be used for proper correction of the DC operation points inside each pixel, it is acceptable, but the time required for correction plays an important role for both chip verification and the design of a big, multi-chip system. Therefore, we present two algorithms: a precise one and a fast one. The first algorithm is based on the noise hits profiles obtained during so called threshold scan procedures. The fast correction procedure is based on the trim DACs scan and it takes less than a minute in a SPC detector systems consisting of several thousands of pixels.
Geo-correction Algorithm Based on Equivalent RD Model for ScanSAR of HJ-1-C Satellite
Liu Jia-yin; Wen Shuang-yan; Zhang Hong-yi; Hong Wen
2014-01-01
HJ-1-C satellite is the first Synthetic Aperture Radar (SAR) satellite for civilian use in China, and it has a strip and scan mode. According to the characteristics of the ScanSAR of the HJ-1-C satellite, a geo-correction algorithm based on an equivalent RD model has been outlined in this paper on the basis of an ECS image processing algorithm and a traditional Range-Doppler location method. An azimuth mosaic was presented by a time series relationship, then the different burst was stitched b...
Themistocleous, Kyriacos; Hadjimitsis, Diofantos G.; Alexakis, Dimitrios
2011-11-01
Darkest pixel atmospheric correction is the simplest and fully image-based correction method. This paper presents an overview of a proposed 'fast atmospheric correction algorithm' developed at MATLAB based on the RT equation basics and the darkest pixel approach. The task is to retrieve the aerosol optical thickness (AOT) from the application of this atmospheric correction. The effectiveness of this algorithm is performed by comparing the AOT values from the algorithm with those measured in-situ both from MICROTOPS II hand-held sunphotometer and the CIMEL sunphotometer (AERONET).
Filli, Lukas; Finkenstaedt, Tim; Andreisek, Gustav; Guggenberger, Roman [University Hospital of Zurich, Department of Diagnostic and Interventional Radiology, Zurich (Switzerland); Marcon, Magda [University Hospital of Zurich, Department of Diagnostic and Interventional Radiology, Zurich (Switzerland); University of Udine, Institute of Diagnostic Radiology, Department of Medical and Biological Sciences, Udine (Italy); Scholz, Bernhard [Imaging and Therapy Division, Siemens AG, Healthcare Sector, Forchheim (Germany); Calcagni, Maurizio [University Hospital of Zurich, Division of Plastic Surgery and Hand Surgery, Zurich (Switzerland)
2014-12-15
The aim of this study was to evaluate a prototype correction algorithm to reduce metal artefacts in flat detector computed tomography (FDCT) of scaphoid fixation screws. FDCT has gained interest in imaging small anatomic structures of the appendicular skeleton. Angiographic C-arm systems with flat detectors allow fluoroscopy and FDCT imaging in a one-stop procedure emphasizing their role as an ideal intraoperative imaging tool. However, FDCT imaging can be significantly impaired by artefacts induced by fixation screws. Following ethical board approval, commercially available scaphoid fixation screws were inserted into six cadaveric specimens in order to fix artificially induced scaphoid fractures. FDCT images corrected with the algorithm were compared to uncorrected images both quantitatively and qualitatively by two independent radiologists in terms of artefacts, screw contour, fracture line visibility, bone visibility, and soft tissue definition. Normal distribution of variables was evaluated using the Kolmogorov-Smirnov test. In case of normal distribution, quantitative variables were compared using paired Student's t tests. The Wilcoxon signed-rank test was used for quantitative variables without normal distribution and all qualitative variables. A p value of < 0.05 was considered to indicate statistically significant differences. Metal artefacts were significantly reduced by the correction algorithm (p < 0.001), and the fracture line was more clearly defined (p < 0.01). The inter-observer reliability was ''almost perfect'' (intra-class correlation coefficient 0.85, p < 0.001). The prototype correction algorithm in FDCT for metal artefacts induced by scaphoid fixation screws may facilitate intra- and postoperative follow-up imaging. (orig.)
Shi, Haixiang; Schmidt, Bertil; Liu, Weiguo; Müller-Wittig, Wolfgang
2010-04-01
Emerging DNA sequencing technologies open up exciting new opportunities for genome sequencing by generating read data with a massive throughput. However, produced reads are significantly shorter and more error-prone compared to the traditional Sanger shotgun sequencing method. This poses challenges for de novo DNA fragment assembly algorithms in terms of both accuracy (to deal with short, error-prone reads) and scalability (to deal with very large input data sets). In this article, we present a scalable parallel algorithm for correcting sequencing errors in high-throughput short-read data so that error-free reads can be available before DNA fragment assembly, which is of high importance to many graph-based short-read assembly tools. The algorithm is based on spectral alignment and uses the Compute Unified Device Architecture (CUDA) programming model. To gain efficiency we are taking advantage of the CUDA texture memory using a space-efficient Bloom filter data structure for spectrum membership queries. We have tested the runtime and accuracy of our algorithm using real and simulated Illumina data for different read lengths, error rates, input sizes, and algorithmic parameters. Using a CUDA-enabled mass-produced GPU (available for less than US$400 at any local computer outlet), this results in speedups of 12-84 times for the parallelized error correction, and speedups of 3-63 times for both sequential preprocessing and parallelized error correction compared to the publicly available Euler-SR program. Our implementation is freely available for download from http://cuda-ec.sourceforge.net .
High-Speed Atmospheric Correction Algorithm for Spectral Image Processing Project
National Aeronautics and Space Administration — Generating land and ocean data products from NASA multispectral and hyperspectral imagery missions requires atmospheric correction, the removal of atmospheric...
Kim, Ye-Seul; Park, Hye-Suk; Kim, Hee-Joung [Yonsei University, Wonju (Korea, Republic of); Choi, Young-Wook; Choi, Jae-Gu [Korea Electrotechnology Research Institute, Ansan (Korea, Republic of)
2014-12-15
Digital breast tomosynthesis (DBT) is a technique that was developed to overcome the limitations of conventional digital mammography by reconstructing slices through the breast from projections acquired at different angles. In developing and optimizing DBT, The x-ray scatter reduction technique remains a significant challenge due to projection geometry and radiation dose limitations. The most common approach to scatter reduction is a beam-stop-array (BSA) algorithm; however, this method raises concerns regarding the additional exposure involved in acquiring the scatter distribution. The compressed breast is roughly symmetric, and the scatter profiles from projections acquired at axially opposite angles are similar to mirror images. The purpose of this study was to apply the BSA algorithm with only two scans with a beam stop array, which estimates the scatter distribution with minimum additional exposure. The results of the scatter correction with angular interpolation were comparable to those of the scatter correction with all scatter distributions at each angle. The exposure increase was less than 13%. This study demonstrated the influence of the scatter correction obtained by using the BSA algorithm with minimum exposure, which indicates its potential for practical applications.
DING Yingqiang; DU Liufeng; YANG Ting; SUN Yugeng
2009-01-01
Sensor localization is crucial for the configuration and applications of wireless sensor network (WSN). A novel distributed localization algorithm, MDS-DC was proposed for wireless sensor network based on multidi-mensional scaling (MDS) and the shortest path distance correction. In MDS-DC, several local positioning regions with reasonable distribution were firstly constructed by an adaptive search algorithm, which ensures the mergence between the local relative maps of the adjacent local position regions and can reduce the number of common nodes in the network. Then, based on the relationships between the estimated distances and actual distances of anchors, the distance estimation vectors of sensors around anchors were corrected in each local positioning region. During the computations of the local relative coordinates, an iterative process, which is the combination of classical MDS algorithm and SMACOF algorithm, was applied. Finally, the global relative positions or absolute positions of sen-sors were obtained through merging the relative maps of all local positioning regions. Simulation results show that MDS-DC has better performances in positioning precision, energy efficiency and robustness to range error, which can meet the requirements of applications for sensor localization in WSN.
Qingbo Li
2013-01-01
Full Text Available In order to improve the predictive accuracy of human blood glucose quantitative analysis model with fourier transform infrared (FT-IR spectroscopy, this paper uses a method named improved extended multiplicative scatter correction (Im-EMSC, which can effectively eliminate the scattering effects caused by human body strong scattering. The principal components of the differential spectra are used instead of the pure spectra of the analytes in this algorithm. Calibrate the unwanted physical characteristic through the shape of the curve of principal components, and extract the original glucose concentration information. Im-EMSC can efficiently remove most of the pathlength difference and baseline shift influences. Firstly, Im-EMSC is used as a preprocessing method, and then partial least squares (PLS regression method is adopted to establish a quantitative analysis model. In this paper, the result of Im-EMSC is compared with those popular scattering correction algorithms of multiplicative scatter correction (MSC and extended multiplicative scatter correction (EMSC preprocessing methods. Experimental results show that the prediction accuracy has been greatly improved with Im-EMSC method, which is helpful for human noninvasive glucose concentration detection technology.
Upper Bounds on the Number of Errors Corrected by the Koetter–Vardy Algorithm
Justesen, Jørn
2007-01-01
By introducing a few simplifying assumptions we derive a simple condition for successful decoding using the Koetter-Vardy algorithm for soft-decision decoding of Reed-Solomon codes. We show that the algorithm has a significant advantage over hard decision decoding when the code rate is low, when ...
Walther, T; Quandt, E; Stegmann, H; Thesen, A; Benner, G
2006-01-01
The first 200 kV scanning transmission electron microscope (STEM) with an imaging energy filter, a monochromator and a corrector for the spherical aberration (Cs-corrector) of the illumination system has been built and tested. The STEM/TEM concept with Koehler illumination allows to switch easily between STEM mode for analytical and TEM mode for high-resolution or in situ studies. The Cs-corrector allows the use of large illumination angles for retaining a sufficiently high beam current despite the intensity loss in the monochromator. With the monochromator on and a 3 microm slit in the dispersion plane that gives 0.26 eV full-width at half-maximum (FWHM) energy resolution we have obtained so far an electron beam smaller than 0.20 nm in diameter (FWHM as measured by scanning the spot quickly over the CCD) which contains 7 pA current and, according to simulations, should be around 0.12 nm in true size. A high-angle annular dark field (ADF) image with isotropic resolution better than 0.28 nm has been recorded with the monochromator in the above configuration and the Cs-corrector on. The beam current is still somewhat low for electron energy-loss spectroscopy (EELS) but is expected to increase substantially by optimising the condenser set-up and using a somewhat larger condenser aperture.
Walther, T. [Center of Advanced European Studies and Research (caesar), Ludwig-Erhard-Allee 2, D-53175 Bonn (Germany)]. E-mail: walther@caesar.de; Quandt, E. [Center of Advanced European Studies and Research (caesar), Ludwig-Erhard-Allee 2, D-53175 Bonn (Germany); Stegmann, H. [Carl Zeiss Nano Technology Systems GmbH, Carl-Zeiss-Str. 56, D-73447 Oberkochen (Germany); Thesen, A. [Carl Zeiss Nano Technology Systems GmbH, Carl-Zeiss-Str. 56, D-73447 Oberkochen (Germany); Benner, G. [Carl Zeiss Nano Technology Systems GmbH, Carl-Zeiss-Str. 56, D-73447 Oberkochen (Germany)
2006-10-15
The first 200 kV scanning transmission electron microscope (STEM) with an imaging energy filter, a monochromator and a corrector for the spherical aberration (C {sub s}-corrector) of the illumination system has been built and tested. The STEM/TEM concept with Koehler illumination allows to switch easily between STEM mode for analytical and TEM mode for high-resolution or in situ studies. The C{sub s}-corrector allows the use of large illumination angles for retaining a sufficiently high beam current despite the intensity loss in the monochromator. With the monochromator on and a 3 {mu}m slit in the dispersion plane that gives 0.26 eV full-width at half-maximum (FWHM) energy resolution we have obtained so far an electron beam smaller than 0.20 nm in diameter (FWHM as measured by scanning the spot quickly over the CCD) which contains 7 pA current and, according to simulations, should be around 0.12 nm in true size. A high-angle annular dark field (ADF) image with isotropic resolution better than 0.28 nm has been recorded with the monochromator in the above configuration and the C {sub s}-corrector on. The beam current is still somewhat low for electron energy-loss spectroscopy (EELS) but is expected to increase substantially by optimising the condenser set-up and using a somewhat larger condenser aperture.
Filtering chromatic aberration for wide acceptance angle electrostatic lenses.
Fazekas, Ádám; Tóth, László
2014-07-01
Chromatic aberration is a major issue for imaging mainly with large acceptance angle electrostatic lenses. Its correction is necessary to take advantage of the outstanding spatial and angular resolution that these lenses provide. We propose a method to eliminate the effect of chromatic aberration on the measured images by determining the impact resulting from higher and lower kinetic energies. Based on a spectral image sequence and a matrix, which describes the transmission function of the lens, a system of linear equations is solved to approximate the 2D spectral intensity distribution of the sample surface. We present the description of our method and preliminary test results, which show significant contrast and image quality improvement. The presented algorithm can also be applied as a software-based energy analyzer.
Y. W. Sun
2013-08-01
Full Text Available In this paper, we present an optimized analysis algorithm for non-dispersive infrared (NDIR to in situ monitor stack emissions. The proposed algorithm simultaneously compensates for nonlinear absorption and cross interference among different gases. We present a mathematical derivation for the measurement error caused by variations in interference coefficients when nonlinear absorption occurs. The proposed algorithm is derived from a classical one and uses interference functions to quantify cross interference. The interference functions vary proportionally with the nonlinear absorption. Thus, interference coefficients among different gases can be modeled by the interference functions whether gases are characterized by linear or nonlinear absorption. In this study, the simultaneous analysis of two components (CO2 and CO serves as an example for the validation of the proposed algorithm. The interference functions in this case can be obtained by least-squares fitting with third-order polynomials. Experiments show that the results of cross interference correction are improved significantly by utilizing the fitted interference functions when nonlinear absorptions occur. The dynamic measurement ranges of CO2 and CO are improved by about a factor of 1.8 and 3.5, respectively. A commercial analyzer with high accuracy was used to validate the CO and CO2 measurements derived from the NDIR analyzer prototype in which the new algorithm was embedded. The comparison of the two analyzers show that the prototype works well both within the linear and nonlinear ranges.
Phase Aberrations in Diffraction Microscopy
Marchesini, S; Chapman, H N; Barty, A; Howells, M R; Spence, J H; Cui, C; Weierstall, U; Minor, A M
2005-09-29
In coherent X-ray diffraction microscopy the diffraction pattern generated by a sample illuminated with coherent x-rays is recorded, and a computer algorithm recovers the unmeasured phases to synthesize an image. By avoiding the use of a lens the resolution is limited, in principle, only by the largest scattering angles recorded. However, the imaging task is shifted from the experiment to the computer, and the algorithm's ability to recover meaningful images in the presence of noise and limited prior knowledge may produce aberrations in the reconstructed image. We analyze the low order aberrations produced by our phase retrieval algorithms. We present two methods to improve the accuracy and stability of reconstructions.
Pablito M. López-Serrano
2016-04-01
Full Text Available Solar radiation is affected by absorption and emission phenomena during its downward trajectory from the Sun to the Earth’s surface and during the upward trajectory detected by satellite sensors. This leads to distortion of the ground radiometric properties (reflectance recorded by satellite images, used in this study to estimate aboveground forest biomass (AGB. Atmospherically-corrected remote sensing data can be used to estimate AGB on a global scale and with moderate effort. The objective of this study was to evaluate four atmospheric correction algorithms (for surface reflectance, ATCOR2 (Atmospheric Correction for Flat Terrain, COST (Cosine of the Sun Zenith Angle, FLAASH (Fast Line-of-sight Atmospheric Analysis of Spectral Hypercubes and 6S (Second Simulation of Satellite Signal in the Solar, and one radiometric correction algorithm (for reflectance at the sensor ToA (Apparent Reflectance at the Top of Atmosphere to estimate AGB in temperate forest in the northeast of the state of Durango, Mexico. The AGB was estimated from Landsat 5 TM imagery and ancillary information from a digital elevation model (DEM using the non-parametric multivariate adaptive regression splines (MARS technique. Field reference data for the model training were collected by systematic sampling of 99 permanent forest growth and soil research sites (SPIFyS established during the winter of 2011. The following predictor variables were identified in the MARS model: Band 7, Band 5, slope (β, Wetness Index (WI, NDVI and MSAVI2. After cross-validation, 6S was found to be the optimal model for estimating AGB (R2 = 0.71 and RMSE = 33.5 Mg·ha−1; 37.61% of the average stand biomass. We conclude that atmospheric and radiometric correction of satellite images can be used along with non-parametric techniques to estimate AGB with acceptable accuracy.
Gu, Xuejun; Li, Jinsheng; Jia, Xun; Jiang, Steve B
2011-01-01
Targeting at developing an accurate and efficient dose calculation engine for online adaptive radiotherapy, we have implemented a finite size pencil beam (FSPB) algorithm with a 3D-density correction method on GPU. This new GPU-based dose engine is built on our previously published ultrafast FSPB computational framework [Gu et al. Phys. Med. Biol. 54 6287-97, 2009]. Dosimetric evaluations against MCSIM Monte Carlo dose calculations are conducted on 10 IMRT treatment plans with heterogeneous treatment regions (5 head-and-neck cases and 5 lung cases). For head and neck cases, when cavities exist near the target, the improvement with the 3D-density correction over the conventional FSPB algorithm is significant. However, when there are high-density dental filling materials in beam paths, the improvement is small and the accuracy of the new algorithm is still unsatisfactory. On the other hand, significant improvement of dose calculation accuracy is observed in all lung cases. Especially when the target is in the m...
Ki, Won-Tai; Choi, Ji-Hyeon; Kim, Byung-Gook; Woo, Sang-Gyun; Cho, Han-Ku
2008-05-01
As the design rule with wafer process is getting smaller down below 50nm node, the specification of CDs on a mask is getting more tightened. Therefore, more tight and accurate E-Beam Lithography simulation is highly required in these days. However, in reality most of E-Beam simulation cases, there is a trade-off relationship between the accuracy and the simulation speed. Moreover, the necessity of full chip based simulation has been increasing in order to estimate more accurate mask CDs based on real process condition. Therefore, without consideration of long range correction algorithm such as fogging effect and loading effect correction in E-beam machine, it would be impossible and meaningless to pursue the full chip based simulation. In this paper, we introduce a breakthrough method to overcome the obstacles of E-Beam simulation. In-house E-beam simulator, ELIS (E-beam LIthography Simulator), has been upgraded to solve these problems. First, DP (Distributed Processing) strategy was applied to improve calculation speed. Secondly, the long range correction algorithm of E-beam machine was also applied to compute intensity of exposure on a full chip based (Mask). Finally, ELIS-DP has been evaluated possibility of expecting or analyzing CDs on full chip base.
Freitag, Martin; Choi, Kang-Hoon; Gutsch, Manuela; Hohle, Christoph; Galler, Reinhard; Krüger, Michael; Weidenmueller, Ulf
2011-04-01
For the manufacturing of semiconductor technologies following the ITRS roadmap, we will face the nodes well below 32nm half pitch in the next 2~3 years. Despite being able to achieve the required resolution, which is now possible with electron beam direct write variable shaped beam (EBDW VSB) equipment and resists, it becomes critical to precisely reproduce dense line space patterns onto a wafer. This exposed pattern must meet the targets from the layout in both dimensions (horizontally and vertically). For instance, the end of a line must be printed in its entire length to allow a later placed contact to be able to land on it. Up to now, the control of printed patterns such as line ends is achieved by a proximity effect correction (PEC) which is mostly based on a dose modulation. This investigation of the line end shortening (LES) includes multiple novel approaches, also containing an additional geometrical correction, to push the limits of the available data preparation algorithms and the measurement. The designed LES test patterns, which aim to characterize the status of LES in a quick and easy way, were exposed and measured at Fraunhofer Center Nanoelectronic Technologies (CNT) using its state of the art electron beam direct writer and CD-SEM. Simulation and exposure results with the novel LES correction algorithms applied to the test pattern and a large production like pattern in the range of our target CDs in dense line space features smaller than 40nm will be shown.
An iterative synthetic aperture imaging algorithm with correction of diffraction effects.
Wennerström, Erik; Stepinski, Tadeusz; Olofsson, Tomas
2006-05-01
In this paper we present an iterative version of the synthetic aperture imaging algorithm extended synthetic aperture technique (ESAFT) proposed recently. The algorithm is based on a linear model that accounts for the distortions effects of an imaging system used for acquisition of ultrasonic data. Improved resolution (both lateral and temporal) in the reconstructed image is obtained as a result of minimizing the reconstruction mean square error. In this work, the minimization is extended to parameters that characterize expected amplitudes of each image element in the area of interest. An iterative optimization scheme is proposed, which in each step performs minimization of the reconstruction error based on the parameter matrix found in the previous step. Comparing to ESAFT, the proposed approach yields a significant improvement in resolution and a high degree of robustness with regard to initial choice of the parameter matrix. Performance of the proposed algorithm is evaluated using both real and simulated ultrasonic data.
Reiner Friedrich
2012-10-01
Full Text Available The outcomes of a prospective consecutive study aimed at evaluating the visual and refractive benefit after cataract surgery with the implantation of the aspheric diffractive multifocal intraocular lens (IOL Tecnis ZMB00 (Abbott Medical Optics are reported. A total of 31 eyes of 19 patients (age range, 40 to 81 years underwent phacoemulsification surgery with implantation of this aspheric multifocal IOL. At 6 months after surgery, postoperative spherical equivalent was within ±1.00 D in 96.8% of eyes, with 94.7% of patients presenting a postoperative binocular far LogMAR uncorrected visual acuity (UCVA of 0.1 or better. Far best-corrected distance VA improved significantly (p < 0.01, with postoperative values of 0.1 or better in 96.8% of eyes. Postoperative near UCVA was 0.10 (equivalent to J1 or better in 93.55% of eyes. Furthermore, the IOL power was found to be very poorly correlated with the postoperative far LogMAR (r = 0.13 and near UCVA (r = 0.13. In conclusion, the aspheric diffractive multifocal IOL Tecnis ZMB00 provides a restoration of the far and near visual function after phacoemulsification surgery for cataract removal or presbyopia correction, which is predictable and independent from the optical power of the implanted IOL.
Meena Prakash, R; Shantha Selva Kumari, R
2017-01-01
The Fuzzy C Means (FCM) and Expectation Maximization (EM) algorithms are the most prevalent methods for automatic segmentation of MR brain images into three classes Gray Matter (GM), White Matter (WM) and Cerebrospinal Fluid (CSF). The major difficulties associated with these conventional methods for MR brain image segmentation are the Intensity Non-uniformity (INU) and noise. In this paper, EM and FCM with spatial information and bias correction are proposed to overcome these effects. The spatial information is incorporated by convolving the posterior probability during E-Step of the EM algorithm with mean filter. Also, a method of pixel re-labeling is included to improve the segmentation accuracy. The proposed method is validated by extensive experiments on both simulated and real brain images from standard database. Quantitative and qualitative results depict that the method is superior to the conventional methods by around 25% and over the state-of-the art method by 8%.
Chun, Se Young [School of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan (Korea, Republic of)
2016-03-15
PET and SPECT are important tools for providing valuable molecular information about patients to clinicians. Advances in nuclear medicine hardware technologies and statistical image reconstruction algorithms enabled significantly improved image quality. Sequentially or simultaneously acquired anatomical images such as CT and MRI from hybrid scanners are also important ingredients for improving the image quality of PET or SPECT further. High-quality anatomical information has been used and investigated for attenuation and scatter corrections, motion compensation, and noise reduction via post-reconstruction filtering and regularization in inverse problems. In this article, we will review works using anatomical information for molecular image reconstruction algorithms for better image quality by describing mathematical models, discussing sources of anatomical information for different cases, and showing some examples.
Pei-Fang (Jennifer Tsai
2012-01-01
Full Text Available Remanufacturing of used products has become a strategic issue for cost-sensitive businesses. Due to the nature of uncertain supply of end-of-life (EoL products, the reverse logistic can only be sustainable with a dynamic production planning for disassembly process. This research investigates the sequencing of disassembly operations as a single-period partial disassembly optimization (SPPDO problem to minimize total disassembly cost. AND/OR graph representation is used to include all disassembly sequences of a returned product. A label correcting algorithm is proposed to find an optimal partial disassembly plan if a specific reusable subpart is retrieved from the original return. Then, a heuristic procedure that utilizes this polynomial-time algorithm is presented to solve the SPPDO problem. Numerical examples are used to demonstrate the effectiveness of this solution procedure.
Santini, F.; Palombo, A.; Dekker, R.J.; Pignatti, S.; Pascucci, S.; Schwering, P.B.W.
2014-01-01
Anomalous pixel responses often seriously affect remote sensing applications, especially in the thermal spectral range. In this paper, a new method to identify and correct anomalous pixel responses is presented. The method was specifically developed to handle with hyperspectral data and is based on
A new algorithm for detecting and correcting bad pixels in infrared images
Andrés David Restrepo Girón
2012-10-01
Full Text Available An image processing algorithm detects and replaces abnormal pixels individually, highlighting them amongst their neighbours in a sequence of thermal images without affecting overall texture, like classical filtering does. Bad pixels from manufacture or constant use of a CCD device in an IR camera are thus detected and replaced with a very good success rate, thereby reducing the risk of bad interpretation. Some thermal sequences from CFRP plates, taken by a Cincinnati Electronics InSb IR camera, were used for developing and testing this algorithm. The results were compared to a detailed list of bad pixels given by the manufacturer (about 70% coincidence. This work becomes relevant considering that the number of papers on this subject is low; most of them talk about astronomical image pre-processing. Moreover, thermo graphic non-destructive testing (TNDT techniques are gaining popularity in Colombia at introductory levels in industrial sectors such as energy generation and transmission, sugar production and military aeronautics.
Bouchard, Hugo; Bielajew, Alex
2015-07-07
To establish a theoretical framework for generalizing Monte Carlo transport algorithms by adding external electromagnetic fields to the Boltzmann radiation transport equation in a rigorous and consistent fashion. Using first principles, the Boltzmann radiation transport equation is modified by adding a term describing the variation of the particle distribution due to the Lorentz force. The implications of this new equation are evaluated by investigating the validity of Fano's theorem. Additionally, Lewis' approach to multiple scattering theory in infinite homogeneous media is redefined to account for the presence of external electromagnetic fields. The equation is modified and yields a description consistent with the deterministic laws of motion as well as probabilistic methods of solution. The time-independent Boltzmann radiation transport equation is generalized to account for the electromagnetic forces in an additional operator similar to the interaction term. Fano's and Lewis' approaches are stated in this new equation. Fano's theorem is found not to apply in the presence of electromagnetic fields. Lewis' theory for electron multiple scattering and moments, accounting for the coupling between the Lorentz force and multiple elastic scattering, is found. However, further investigation is required to develop useful algorithms for Monte Carlo and deterministic transport methods. To test the accuracy of Monte Carlo transport algorithms in the presence of electromagnetic fields, the Fano cavity test, as currently defined, cannot be applied. Therefore, new tests must be designed for this specific application. A multiple scattering theory that accurately couples the Lorentz force with elastic scattering could improve Monte Carlo efficiency. The present study proposes a new theoretical framework to develop such algorithms.
Karlsen, Haakon; Tao Dong
2015-08-01
This paper presents the preliminary work of developing a smart phone based application for colorimetric detection of Urinary Tract Infection. The purpose is to make a smart phone function as a practical point-of-care device for nurses or medical personnel without access to strip readers. The main challenge is the constancy of camera color perception across different illuminations and devices, which is the first step towards a practical solution without additional equipment. A reported black and white reference correction and a comprehensive color image normalization have been utilized in this work. Comprehensive color image normalization appears to be quite effective at correcting the difference in perceived color due to different illumination, and is therefore a candidate for inclusion in the further work.
Static scene statistical algorithm for nonuniformity correction in focal-plane arrays
Catarius, Adrian M.; Seal, Michael D.
2015-10-01
A static scene statistical nonuniformity correction (S3NUC) method was developed based on the higher-order moments of a linear statistical model of a photodetection process. S3NUC relieves the requirement for calibrated targets or a moving scene for NUC by utilizing two data sets of different intensities but requires low scene intensity levels. The first-, second-, and third-order moments of the two data sets are used to estimate the gain and bias values for the detectors in a focal-plane array (FPA). These gain and bias values may then be used to correct the nonuniformities between detectors or to initialize other continuous calibration methods. S3NUC was successfully applied to simulated data as well as measured data at visible wavelengths.
An efficient algorithm for multiphase image segmentation with intensity bias correction.
Zhang, Haili; Ye, Xiaojing; Chen, Yunmei
2013-10-01
This paper presents a variational model for simultaneous multiphase segmentation and intensity bias estimation for images corrupted by strong noise and intensity inhomogeneity. Since the pixel intensities are not reliable samples for region statistics due to the presence of noise and intensity bias, we use local information based on the joint density within image patches to perform image partition. Hence, the pixel intensity has a multiplicative distribution structure. Then, the maximum-a-posteriori (MAP) principle with those pixel density functions generates the model. To tackle the computational problem of the resultant nonsmooth nonconvex minimization, we relax the constraint on the characteristic functions of partition regions, and apply primal-dual alternating gradient projections to construct a very efficient numerical algorithm. We show that all the variables have closed-form solutions in each iteration, and the computation complexity is very low. In particular, the algorithm involves only regular convolutions and pointwise projections onto the unit ball and canonical simplex. Numerical tests on a variety of images demonstrate that the proposed algorithm is robust, stable, and attains significant improvements on accuracy and efficiency over the state-of-the-arts.
Seo, Chang-Woo; Cha, Bo Kyung; Jeon, Sungchae; Huh, Young [Converged Medical Device Research Center, Advanced Medical Device Research Division, KERI, Gyeonggido 426-910 (Korea, Republic of)
2015-07-01
Recently, beam hardening reduction is required to produce high-quality reconstructions of X-ray cone-beam computed tomography (CBCT) system for medical applications. This paper introduces the iterative total variation (ITV) for filtered-backprojection suffering from the serious beam hardening problems. Feldkamp, Davis, and Kress (FDK) reconstruction algorithm for CBCT system is widely used reconstruction technique. FDK reconstruction algorithm could be realized by generating the weighted projection data, filtering the projection images, and back-projecting the filtered projection data into the volume. However, FDK algorithm suffers from the beam hardening artifacts by X-ray attenuation coefficients. Recently, total variation (TV) method for compressed sensing (CS) has been particularly useful in exploiting the prior knowledge of minimal variation in the X-ray attenuation characteristics across object or human body. But a practical implementation of this method still remains a challenge. The main problem is the iterative nature of solving the TV-based CS formulation, which generally requires multiple iterations of forward and backward projections of a large dataset in clinically or industrially feasible time frame. In this paper, we propose ITV method after FDK reconstruction for reducing the beam hardening artifacts. The beam hardening problems are reduced by the ITV method to promote sparsity inherent in the X-ray attenuation characteristics. (authors)
An algorithm for noise correction of dual-energy computed tomography material density images.
Maia, Rafael Simon; Jacob, Christian; Hara, Amy K; Silva, Alvin C; Pavlicek, William; Ross, Mitchell J
2015-01-01
Dual-energy computed tomography (DECT) images can undergo a two-material decomposition process which results in two images containing material density information. Material density images obtained by that process result in images with increased pixel noise. Noise reduction in those images is desirable in order to improve image quality. A noise reduction algorithm for material density images was developed and tested. A three-level wavelet approach combined with the application of an anisotropic diffusion filter was used. During each level, the resulting noise maps are further processed, until the original resolution is reached and the final noise maps obtained. Our method works in image space and, therefore, can be applied to any type of material density images obtained from any DECT vendor. A quantitative evaluation of the noise-reduced images using the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and 2D noise power spectrum was done to quantify the improvements. The noise reduction algorithm was applied to a set of images resulting in images with higher SNR and CNR than the raw density images obtained by the decomposition process. The average improvement in terms of SNR gain was about 49 % while CNR gain was about 52 %. The difference between the raw and filtered regions of interest mean values was far from reaching statistical significance (minimum [Formula: see text], average [Formula: see text]). We have demonstrated through a series of quantitative analyses that our novel noise reduction algorithm improves the image quality of DECT material density images.
A new algorithm for the correction of the linear coupling at Tevatron
Alexahin, Y.; Gianfelice-Wendt, E.; /Fermilab
2006-06-01
The Fourier analysis of Turn by Turn (TBT) data provides valuable information about the machine linear and non-linear optics. A program for the measurement and correction of the linear coupling based on the TBT data analysis has been integrated in the TEVATRON control system. The new method is fast, allows the measurement of the coupling during acceleration and offers information about the sum coupling coefficient and the location of the sources of coupling.
张立华; 王兵; 贾丁; 冯恬风; 董慧
2012-01-01
Objective To investigate the changes of wavefront aberrations in keratoconus corrected with rigid gas permeable contact lens (RGPCL).Methods It was a prospective case-control study.Twenty-five patients (43 eyes) confirmed by corneal topography as keratoconus were corrected with RGPCL.Their corrected visual acuity (VA) and wavefront aberrations were detected by iTrace dynamic laserefraction before and after wearing RGPCL for 2 weeks.Lower-order abberations LOAs,higher-order abberation HOAs,coma,spherical and trefoil were measured.The results measured were compared using paired samples t test.Results There were statistic differences in total ocular wavefront aberrations,LOAs,HOAs,coma and trefoil.Total ocular wavefront aberrations were reduced from 9.12±4.20 μm to 1.67±0.92 μm after wearing RGPCL (t=9.062,P＜0.01); LOAs were reduced from 8.88-±3.90 μm to 1.37±0.75 μm after wearing RGPCL (t=9.507,P＜0.01); HOAs were reduced from 1.90±0.14 μm to 0.79±0.21 μm after wearing RGPCL (t=2.473,P＜0.05); coma were reduced from 0.99±0.15 μm to 0.30±0.18 μm after wearing RGPCL (t=2.364,P＜0.05); trefoil were reduced from 0.92±0.19 μm to 0.22±0.14 μm after wearing RGPCL (t=2.757,P＜0.05).There were no statistics differences in spherical abberation.Spherical abberation were reduced from 0.54±0.25 μm to 0.32±0.27 μm after wearing RGPCL (t=1.239,P＞0.05).Conclusion Keratoconus patients with RGPCL can reach satisfying corrected visual acuity and visual quantity.Total ocular wavefront aberrations were significant reduced after wearing RGPCL.%目的 研究圆锥角膜患者配戴硬性透氧性角膜接触镜(RGPCL)后波前像差及视觉质量的改变.方法 前瞻性病例对照研究.收集在山西省眼科医院就诊的圆锥角膜患者25例(43眼),选配合适的RGPCL配戴2周后,分别于配戴前及配戴后测定其矫正视力,采用iTrace波前像差仪进行戴镜前后的全眼波前像差测量,并测量戴镜前后高阶、低阶像差
Algorithmic Verification of Forward Correctability%前向可修正属性算术验证的研究
吴海玲; 周从华; 鞠时光; 王基
2011-01-01
目前验证前向可修正属性的"展开方法"是不完备的,即当"展开定理"的局部条件不满足时,不能判断出系统不满足前向可修正属性.为此,提出一种基于状态转换系统的前向可修正属性验证方法,该方法将前向可修正属性的验证归约为可达性问题,进而可借助可达性检测技术完成属性的验证.该方法是完备的,且当属性不成立时,可以给出使属性失效的反例,反例的给出对非法信息流的消除和控制具有直接的帮助.最后,通过磁臂隐通道的例子说明了方法的有效性和实用性.%Due to the incompleteness of the "Unwinding Theorem",a system can't be judged to fail to satisfy the forward correctability, when some local conditions of "Unwinding Theorem" are not satisfied. This paper proposed an algorithmic verification technique to check the forward correctability based on the state transition system The technique reduces forward correctability checking to the reachability problem and the reduction enables us to use the reachability checking technique to perform forward correctability checking. Our method is complete and it can give a counter-exampies to control and eliminate the illegal information flow when a system fails to satisfy the forward correctability. Finally,Disk-arm Convert Channel illustrates the effectiveness and practicality.
Correction Algorithm of Matching Error for DIBR%适用于DIBR的匹配误差校正算法
张玲; 邰国钦; 刘然; 谢辉; 许小艳
2011-01-01
Due to the variability in virtual visibility, the imprecise depth image and the inaccurate calculation, matching errors may occur in the virtual views synthesized by DIBR (Depth Image-Based Rendering) techniques. In order to solve this problem, a matching error correction algorithm named Zero-Cross Correction ( ZCC) is proposed based on the order matching constraint. ZCC determines the matchi?g error region by analyzing the mapping relations between the pixel points in the destination image and the corresponding matching points in the reference image, and it assigns the matching points of all points in the matching error region to the matching points of the starting point in the same region, thus successfully implementing the correction of matching error. Experimental results indicate that the proposed algorithm is effective in eliminating matching errors and that it can be applied as an additional error detection and correction algorithm to the postprocessing of novel views generated by DIBR because it is totally independent of the 3D image wraping in DIBR.%由于可见性变化、深度图像的不精确性以及计算的不精确等原因,采用基于深度图像绘制(DIBR)技术生成的虚拟视点视图中可能会存在匹配误差.为此,提出了一种适用于DIBR的匹配误差校正算法——零交叉校正(ZCC)算法.该算法建立在顺序匹配约束的基础上,通过分析目标图像像素点与参考图像上对应匹配点的映射关系来确定匹配误差区域,将区域内所有点的匹配点都赋值成起始点的匹配点,从而达到匹配误差校正的目的.实验表明,该算法可以有效地消除匹配误差.由于该算法与DIBR中的三维图像变换过程没有直接联系,因而它可以作为一种附加的误差检测与校正算法应用于DIBR的后处理过程中.
Yu, Wentao
2009-10-23
In this work, the characteristic inversion domain microstructures of In{sub 2}O{sub 3}(ZnO){sub m} (m=30) compounds were investigated by TEM methods. At bright-atom contrast condition, atomically resolved HR-TEM images of In{sub 2}O{sub 3}(ZnO){sub 30} were successfully acquired in [1 anti 100] zone axis of ZnO, with projected metal columns of {proportional_to}1.6 A well resolved. From contrast maxima in the TEM images, local lattice distortions at the pyramidal inversion domain boundaries were observed for the first time. Lattice displacements and the strain field in two-dimensions were visualized and measured using the 'DALI' algorithm. Atomically resolved single shot and focal series images of In{sub 2}O{sub 3}(ZnO){sub 30} were achieved in both zone axes of ZnO, [1 anti 100] and [2 anti 1 anti 10], respectively. The electron waves at the exit-plane were successfully reconstructed using the software package 'TrueImage'. Finally, a three dimensional atomic structure model for the pyramidal IDB was proposed, with an In distribution of 10%, 20%, 40%, 20% and 10% of In contents over 5 atom columns along basal planes, respectively. Through a detailed structural study of In{sub 2}O{sub 3}(ZnO){sub m} compounds by using phase-contrast and Z-contrast imaging at atomic resolution, In{sup 3+} atoms are determined with trigonal bi-pyramidal co-ordination and are distributed at the pyramidal IDBs. (orig.)
Zheng, Ziyi; Sun, Mingshan; Pavkovich, John; Star-Lack, Josh
2011-03-01
A challenge in using on-board cone beam computed tomography (CBCT) to image lung tumor motion prior to radiation therapy treatment is acquiring and reconstructing high quality 4D images in a sufficiently short time for practical use. For the 1 minute rotation times typical of Linacs, severe view aliasing artifacts, including streaks, are created if a conventional phase-correlated FDK reconstruction is performed. The McKinnon-Bates (MKB) algorithm provides an efficient means of reducing streaks from static tissue but can suffer from low SNR and other artifacts due to data truncation and noise. We have added truncation correction and bilateral nonlinear filtering to the MKB algorithm to reduce streaking and improve image quality. The modified MKB algorithm was implemented on a graphical processing unit (GPU) to maximize efficiency. Results show that a nearly 4x improvement in SNR is obtained compared to the conventional FDK phase-correlated reconstruction and that high quality 4D images with 0.4 second temporal resolution and 1 mm3 isotropic spatial resolution can be reconstructed in less than 20 seconds after data acquisition completes.
Improved MODIS Dark Target aerosol optical depth algorithm over land: angular effect correction
Wu, Yerong; de Graaf, Martin; Menenti, Massimo
2016-11-01
Aerosol optical depth (AOD) product retrieved from MODerate Resolution Imaging Spectroradiometer (MODIS) measurements has greatly benefited scientific research in climate change and air quality due to its high quality and large coverage over the globe. However, the current product (e.g., Collection 6) over land needs to be further improved. The is because AOD retrieval still suffers large uncertainty from the surface reflectance (e.g., anisotropic reflection) although the impacts of the surface reflectance have been largely reduced using the Dark Target (DT) algorithm. It has been shown that the AOD retrieval over dark surface can be improved by considering surface bidirectional distribution reflectance function (BRDF) effects in previous study. However, the relationship of the surface reflectance between visible and shortwave infrared band that applied in the previous study can lead to an angular dependence of the AOD retrieval. This has at least two reasons. The relationship based on the assumption of isotropic reflection or Lambertian surface is not suitable for the surface bidirectional reflectance factor (BRF). However, although the relationship varies with the surface cover type by considering the vegetation index NDVISWIR, this index itself has a directional effect and affects the estimation of the surface reflection, and it can lead to some errors in the AOD retrieval. To improve this situation, we derived a new relationship for the spectral surface BRF in this study, using 3 years of data from AERONET-based Surface Reflectance Validation Network (ASRVN). To test the performance of the new algorithm, two case studies were used: 2 years of data from North America and 4 months of data from the global land. The results show that the angular effects of the AOD retrieval are largely reduced in most cases, including fewer occurrences of negative retrievals. Particularly, for the global land case, the AOD retrieval was improved by the new algorithm compared to the
Chen, Huei-Yung; Lu, Nan-Han; Huang, Yung-Hui; Chen, Tai-Been
2015-01-01
Positron emission tomography (PET) had been utilized to image gene therapy, estimate tumor growth, detect neural function of the brain, and diagnose disease. However, sinogram noise always results inaccurate PET images. The factorial design of experiment (DOE), a statistical method, was applied to investigate, correct and estimate the fraction of scattering of 2D sinogram in PET. The DOE was included as factors of angle views and scatter media with two levels designed. The PET sinogram after scattering correction was then reconstructed by filtered back projection (FBP). Both Ge-68 uniform phantom and Jaszczak anthropomorphic torso phantom were applied to exam the performance of presented scattering correction algorithm. The signal-to-noise ratio (SNR), standard deviation (STD) of background, and full width at half maximum (FWHM), and uniformity test were applied to validate the performance of presented method. The proposed method provides a narrower FWHM, smaller STD of the background, higher SNR and better uniformity than those of original protocols. This method should be tested for accuracy and feasibility with three-dimensional phantoms or real animal studies and consideration effects of cross-talk between slices in future work.
An effective correction algorithm for off-axis portal dosimetry errors
Bailey, Daniel W.; Kumaraswamy, Lalith; Podgorsak, Matthew B. [Department of Physics, State University of New York at Buffalo, Buffalo, New York 14260 (United States); Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 (United States)
2009-09-15
Portal dosimetric images acquired for IMRT pretreatment verification show dose errors of up to 15% near the detector edges as compared to dose predictions calculated by a treatment planning system for these off-axis regions. A method is proposed to account for these off-axis effects by precisely correcting the off-axis output factors, which calibrate the imager for absolute dose. Using this method, agreement between the predicted and the measured doses improves by up to 15% for fields near the detector edges, resulting in passing rate improvements of as much as 60% for gamma evaluation of 3 mm, 3% within the collimator jaws.
An effective correction algorithm for off-axis portal dosimetry errors.
Bailey, Daniel W; Kumaraswamy, Lalith; Podgorsak, Matthew B
2009-09-01
Portal dosimetric images acquired for IMRT pretreatment verification show dose errors of up to 15% near the detector edges as compared to dose predictions calculated by a treatment planning system for these off-axis regions. A method is proposed to account for these off-axis effects by precisely correcting the off-axis output factors, which calibrate the imager for absolute dose. Using this method, agreement between the predicted and the measured doses improves by up to 15% for fields near the detector edges, resulting in passing rate improvements of as much as 60% for gamma evaluation of 3 mm, 3% within the collimator jaws.
Sonali Sachin Sankpal
2016-01-01
Full Text Available Scattering and absorption of light is main reason for limited visibility in water. The suspended particles and dissolved chemical compounds in water are also responsible for scattering and absorption of light in water. The limited visibility in water results in degradation of underwater images. The visibility can be increased by using artificial light source in underwater imaging system. But the artificial light illuminates the scene in a nonuniform fashion. It produces bright spot at the center with the dark region at surroundings. In some cases imaging system itself creates dark region in the image by producing shadow on the objects. The problem of nonuniform illumination is neglected by the researchers in most of the image enhancement techniques of underwater images. Also very few methods are discussed showing the results on color images. This paper suggests a method for nonuniform illumination correction for underwater images. The method assumes that natural underwater images are Rayleigh distributed. This paper used maximum likelihood estimation of scale parameter to map distribution of image to Rayleigh distribution. The method is compared with traditional methods for nonuniform illumination correction using no-reference image quality metrics like average luminance, average information entropy, normalized neighborhood function, average contrast, and comprehensive assessment function.
Simplified ASE correction algorithm for variable gain-flattened erbium-doped fiber amplifier.
Mahdi, Mohd Adzir; Sheih, Shou-Jong; Adikan, Faisal Rafiq Mahamd
2009-06-08
We demonstrate a simplified algorithm to manifest the contribution of amplified spontaneous emission in variable gain-flattened Erbium-doped fiber amplifier (EDFA). The detected signal power at the input and output ports of EDFA comprises of both signal and noise. The generated amplified spontaneous emission from EDFA cannot be differentiated by photodetector which leads to underestimation of the targeted gain value. This gain penalty must be taken into consideration in order to obtain the accurate gain level. By taking the average gain penalty within the dynamic gain range, the targeted output power is set higher than the desired level. Thus, the errors are significantly reduced to less than 0.15 dB from 15 dB to 30 dB desired gain values.
Development of a Multiview Time Domain Imaging Algorithm (MTDI) with a Fermat Correction
Fisher, K A; Lehman, S K; Chambers, D H
2004-09-22
An imaging algorithm is presented based on the standard assumption that the total scattered field can be separated into an elastic component with monopole like dependence and an inertial component with a dipole like dependence. The resulting inversion generates two separate image maps corresponding to the monopole and dipole terms of the forward model. The complexity of imaging flaws and defects in layered elastic media is further compounded by the existence of high contrast gradients in either sound speed and/or density from layer to layer. To compensate for these gradients, we have incorporated Fermat's method of least time into our forward model to determine the appropriate delays between individual source-receiver pairs. Preliminary numerical and experimental results are in good agreement with each other.
Rui, Xue; Cheng, Lishui; Long, Yong; Fu, Lin; Alessio, Adam M.; Asma, Evren; Kinahan, Paul E.; De Man, Bruno
2015-09-01
For PET/CT systems, PET image reconstruction requires corresponding CT images for anatomical localization and attenuation correction. In the case of PET respiratory gating, multiple gated CT scans can offer phase-matched attenuation and motion correction, at the expense of increased radiation dose. We aim to minimize the dose of the CT scan, while preserving adequate image quality for the purpose of PET attenuation correction by introducing sparse view CT data acquisition. We investigated sparse view CT acquisition protocols resulting in ultra-low dose CT scans designed for PET attenuation correction. We analyzed the tradeoffs between the number of views and the integrated tube current per view for a given dose using CT and PET simulations of a 3D NCAT phantom with lesions inserted into liver and lung. We simulated seven CT acquisition protocols with {984, 328, 123, 41, 24, 12, 8} views per rotation at a gantry speed of 0.35 s. One standard dose and four ultra-low dose levels, namely, 0.35 mAs, 0.175 mAs, 0.0875 mAs, and 0.043 75 mAs, were investigated. Both the analytical Feldkamp, Davis and Kress (FDK) algorithm and the Model Based Iterative Reconstruction (MBIR) algorithm were used for CT image reconstruction. We also evaluated the impact of sinogram interpolation to estimate the missing projection measurements due to sparse view data acquisition. For MBIR, we used a penalized weighted least squares (PWLS) cost function with an approximate total-variation (TV) regularizing penalty function. We compared a tube pulsing mode and a continuous exposure mode for sparse view data acquisition. Global PET ensemble root-mean-squares-error (RMSE) and local ensemble lesion activity error were used as quantitative evaluation metrics for PET image quality. With sparse view sampling, it is possible to greatly reduce the CT scan dose when it is primarily used for PET attenuation correction with little or no measureable effect on the PET image. For the four ultra-low dose
Rui, Xue; Cheng, Lishui; Long, Yong; Fu, Lin; Alessio, Adam M; Asma, Evren; Kinahan, Paul E; De Man, Bruno
2015-10-07
For PET/CT systems, PET image reconstruction requires corresponding CT images for anatomical localization and attenuation correction. In the case of PET respiratory gating, multiple gated CT scans can offer phase-matched attenuation and motion correction, at the expense of increased radiation dose. We aim to minimize the dose of the CT scan, while preserving adequate image quality for the purpose of PET attenuation correction by introducing sparse view CT data acquisition.We investigated sparse view CT acquisition protocols resulting in ultra-low dose CT scans designed for PET attenuation correction. We analyzed the tradeoffs between the number of views and the integrated tube current per view for a given dose using CT and PET simulations of a 3D NCAT phantom with lesions inserted into liver and lung. We simulated seven CT acquisition protocols with {984, 328, 123, 41, 24, 12, 8} views per rotation at a gantry speed of 0.35 s. One standard dose and four ultra-low dose levels, namely, 0.35 mAs, 0.175 mAs, 0.0875 mAs, and 0.043 75 mAs, were investigated. Both the analytical Feldkamp, Davis and Kress (FDK) algorithm and the Model Based Iterative Reconstruction (MBIR) algorithm were used for CT image reconstruction. We also evaluated the impact of sinogram interpolation to estimate the missing projection measurements due to sparse view data acquisition. For MBIR, we used a penalized weighted least squares (PWLS) cost function with an approximate total-variation (TV) regularizing penalty function. We compared a tube pulsing mode and a continuous exposure mode for sparse view data acquisition. Global PET ensemble root-mean-squares-error (RMSE) and local ensemble lesion activity error were used as quantitative evaluation metrics for PET image quality.With sparse view sampling, it is possible to greatly reduce the CT scan dose when it is primarily used for PET attenuation correction with little or no measureable effect on the PET image. For the four ultra-low dose levels
Image-based EUVL aberration metrology
Fenger, Germain Louis
A significant factor in the degradation of nanolithographic image fidelity is optical wavefront aberration. As resolution of nanolithography systems increases, effects of wavefront aberrations on aerial image become more influential. The tolerance of such aberrations is governed by the requirements of features that are being imaged, often requiring lenses that can be corrected with a high degree of accuracy and precision. Resolution of lithographic systems is driven by scaling wavelength down and numerical aperture (NA) up. However, aberrations are also affected from the changes in wavelength and NA. Reduction in wavelength or increase in NA result in greater impact of aberrations, where the latter shows a quadratic dependence. Current demands in semiconductor manufacturing are constantly pushing lithographic systems to operate at the diffraction limit; hence, prompting a need to reduce all degrading effects on image properties to achieve maximum performance. Therefore, the need for highly accurate in-situ aberration measurement and correction is paramount. In this work, an approach has been developed in which several targets including phase wheel, phase disk, phase edges, and binary structures are used to generate optical images to detect and monitor aberrations in extreme ultraviolet (EUV) lithographic systems. The benefit of using printed patterns as opposed to other techniques is that the lithography system is tested under standard operating conditions. Mathematical models in conjunction with iterative lithographic simulations are used to determine pupil phase wavefront errors and describe them as combinations of Zernike polynomials.
Description and comparison of algorithms for correcting anisotropic magnification in cryo-EM images
Zhao, Jianhua; Benlekbir, Samir; Rubinstein, John L
2015-01-01
Single particle electron cryomicroscopy (cryo-EM) allows for structures of proteins and protein complexes to be determined from images of non-crystalline specimens. Cryo-EM data analysis requires electron microscope images of randomly oriented ice-embedded protein particles to be rotated and translated to allow for coherent averaging when calculating three-dimensional (3-D) structures. Rotation of 2-D images is usually done with the assumption that the magnification of the electron microscope is the same in all directions, a condition that has been found to be untrue with some electron microscopes when used with the settings necessary for cryo-EM with a direct detector device (DDD) camera (Grant and Grigorieff, in preparation). Correction of images by linear interpolation in real space has allowed high-resolution structures to be calculated from cryo-EM images for symmetric particles (Grant and Grigorieff, in preparation). Here we describe and compare a simple real space method and a somewhat more sophisticat...
Ratliff, Bradley M.; LeMaster, Daniel A.
2012-06-01
Pixel-to-pixel response nonuniformity is a common problem that affects nearly all focal plane array sensors. This results in a frame-to-frame fixed pattern noise (FPN) that causes an overall degradation in collected data. FPN is often compensated for through the use of blackbody calibration procedures; however, FPN is a particularly challenging problem because the detector responsivities drift relative to one another in time, requiring that the sensor be recalibrated periodically. The calibration process is obstructive to sensor operation and is therefore only performed at discrete intervals in time. Thus, any drift that occurs between calibrations (along with error in the calibration sources themselves) causes varying levels of residual calibration error to be present in the data at all times. Polarimetric microgrid sensors are particularly sensitive to FPN due to the spatial differencing involved in estimating the Stokes vector images. While many techniques exist in the literature to estimate FPN for conventional video sensors, few have been proposed to address the problem in microgrid imaging sensors. Here we present a scene-based nonuniformity correction technique for microgrid sensors that is able to reduce residual fixed pattern noise while preserving radiometry under a wide range of conditions. The algorithm requires a low number of temporal data samples to estimate the spatial nonuniformity and is computationally efficient. We demonstrate the algorithm's performance using real data from the AFRL PIRATE and University of Arizona LWIR microgrid sensors.
Pontone, Gianluca; Bertella, Erika; Baggiano, Andrea; Mushtaq, Saima; Loguercio, Monica; Segurini, Chiara; Conte, Edoardo; Beltrama, Virginia; Annoni, Andrea; Formenti, Alberto; Petulla, Maria; Trabattoni, Daniela; Pepi, Mauro [Centro Cardiologico Monzino, IRCCS, Milan (Italy); Andreini, Daniele; Montorsi, Piero; Bartorelli, Antonio L. [Centro Cardiologico Monzino, IRCCS, Milan (Italy); University of Milan, Department of Cardiovascular Sciences and Community Health, Milan (Italy); Guaricci, Andrea I. [University of Foggia, Department of Cardiology, Foggia (Italy)
2016-01-15
The aim of this study was to evaluate the impact of a novel intra-cycle motion correction algorithm (MCA) on overall evaluability and diagnostic accuracy of cardiac computed tomography coronary angiography (CCT). From a cohort of 900 consecutive patients referred for CCT for suspected coronary artery disease (CAD), we enrolled 160 (18 %) patients (mean age 65.3 ± 11.7 years, 101 male) with at least one coronary segment classified as non-evaluable for motion artefacts. The CCT data sets were evaluated using a standard reconstruction algorithm (SRA) and MCA and compared in terms of subjective image quality, evaluability and diagnostic accuracy. The mean heart rate during the examination was 68.3 ± 9.4 bpm. The MCA showed a higher Likert score (3.1 ± 0.9 vs. 2.5 ± 1.1, p < 0.001) and evaluability (94%vs.79 %, p < 0.001) than the SRA. In a 45-patient subgroup studied by clinically indicated invasive coronary angiography, specificity, positive predictive value and accuracy were higher in MCA vs. SRA in segment-based and vessel-based models, respectively (87%vs.73 %, 50%vs.34 %, 85%vs.73 %, p < 0.001 and 62%vs.28 %, 66%vs.51 % and 75%vs.57 %, p < 0.001). In a patient-based model, MCA showed higher accuracy vs. SCA (93%vs.76 %, p < 0.05). MCA can significantly improve subjective image quality, overall evaluability and diagnostic accuracy of CCT. (orig.)
Barbara Bulgarelli
2003-12-01
Full Text Available The accuracy analysis of an approximate atmospheric correction algorithm for the processing of SeaWiFS data has been investigated for the Baltic Sea. The analysis made use of theoretical radiances produced with the FEM radiative transfer code for representative atmosphere-water test cases. The study showed uncertainties in the determination of the aerosol optical thickness at 865 nm and of the Ångström exponent lower than ± 5% and ± 10%, respectively. These results were confirmed by the analysis of 59 match-ups between satellite-derived and in situ measurements for a site located in the central Baltic. Because of the relatively high yellow substance absorption, often combined with the slanted solar illumination, the retrieval of the water-leaving radiance in the blue part of the spectrum appeared to be highly degraded, to the extent that almost no correlation was found between retrieved and simulated values. Better results were obtained at the other wavelengths. The accuracy in the estimation of the remote sensing reflectance ratio R35 decreased with diminishing chlorophyll a concentration and increasing yellow substance absorption, ranging between ± 7% and ± 47%. The propagation of R35 uncertainties on chlorophyll a estimation was quantified. Keeping the same atmosphere-water conditions, the atmospheric correction scheme appeared sensitive to seasonal changes in the Sun zenith.
Mashouf, S; Lai, P [University of Toronto, Medical Biophysics Dept., Toronto, ON (Canada); Karotki, A; Keller, B; Beachey, D; Pignol, J [Sunnybrook Health Sciences Centre, Toronto, ON (Canada)
2014-06-01
Purpose: Seed brachytherapy is currently used for adjuvant radiotherapy of early stage prostate and breast cancer patients. The current standard for calculation of dose surrounding the brachytherapy seeds is based on American Association of Physicist in Medicine Task Group No. 43 (TG-43 formalism) which generates the dose in homogeneous water medium. Recently, AAPM Task Group No. 186 emphasized the importance of accounting for tissue heterogeneities. This can be done using Monte Carlo (MC) methods, but it requires knowing the source structure and tissue atomic composition accurately. In this work we describe an efficient analytical dose inhomogeneity correction algorithm implemented using MIM Symphony treatment planning platform to calculate dose distributions in heterogeneous media. Methods: An Inhomogeneity Correction Factor (ICF) is introduced as the ratio of absorbed dose in tissue to that in water medium. ICF is a function of tissue properties and independent of source structure. The ICF is extracted using CT images and the absorbed dose in tissue can then be calculated by multiplying the dose as calculated by the TG-43 formalism times ICF. To evaluate the methodology, we compared our results with Monte Carlo simulations as well as experiments in phantoms with known density and atomic compositions. Results: The dose distributions obtained through applying ICF to TG-43 protocol agreed very well with those of Monte Carlo simulations as well as experiments in all phantoms. In all cases, the mean relative error was reduced by at least 50% when ICF correction factor was applied to the TG-43 protocol. Conclusion: We have developed a new analytical dose calculation method which enables personalized dose calculations in heterogeneous media. The advantages over stochastic methods are computational efficiency and the ease of integration into clinical setting as detailed source structure and tissue segmentation are not needed. University of Toronto, Natural Sciences and
Hering, Julian; Waller, Erik H.; von Freymann, Georg
2017-02-01
Since a large number of optical systems and devices are based on differently shaped focal intensity distributions (point-spread-functions, PSF), the PSF's quality is crucial for the application's performance. E.g., optical tweezers, optical potentials for trapping of ultracold atoms as well as stimulated-emission-depletion (STED) based microscopy and lithography rely on precisely controlled intensity distributions. However, especially in high numerical aperture (NA) systems, such complex laser modes are easily distorted by aberrations leading to performance losses. Although different approaches addressing phase retrieval algorithms have been recently presented[1-3], fast and automated aberration compensation for a broad variety of complex shaped PSFs in high NA systems is still missing. Here, we report on a Gerchberg-Saxton[4] based algorithm (GSA) for automated aberration correction of arbitrary PSFs, especially for high NA systems. Deviations between the desired target intensity distribution and the three-dimensionally (3D) scanned experimental focal intensity distribution are used to calculate a correction phase pattern. The target phase distribution plus the correction pattern are displayed on a phase-only spatial-light-modulator (SLM). Focused by a high NA objective, experimental 3D scans of several intensity distributions allow for characterization of the algorithms performance: aberrations are reliably identified and compensated within less than 10 iterations. References 1. B. M. Hanser, M. G. L. Gustafsson, D. A. Agard, and J. W. Sedat, "Phase-retrieved pupil functions in wide-field fluorescence microscopy," J. of Microscopy 216(1), 32-48 (2004). 2. A. Jesacher, A. Schwaighofer, S. Frhapter, C. Maurer, S. Bernet, and M. Ritsch-Marte, "Wavefront correction of spatial light modulators using an optical vortex image," Opt. Express 15(9), 5801-5808 (2007). 3. A. Jesacher and M. J. Booth, "Parallel direct laser writing in three dimensions with spatially dependent
Environmental TEM in an Aberration Corrected Microscope
Hansen, Thomas Willum; Wagner, Jakob Birkedal
the microscope column. The effects of gas on the electron wave in the objective lens are not well understood and needs further attention. Imaging samples with a simple geometry, such as gold particles on a flat graphene substrate and analyzing the variations in contrast, provides a means for understanding...... when traversing the pole piece gap was measured by recording the signal outside the sample region on the pre‐GIF CCD camera (see Figure 1 left). The effects on high resolution imaging were investigated by imaging gold nanoparticles below 5nm in diameter (see Figure 1 middle and right). We will present...... results from imaging in various elemental as well as di‐molecular gases and their effect on imaging and spectroscopy in the environmental transmission electron microscope....
Correcting Aberrated Wavefronts from Synthetic Apertures Holographically.
1986-12-01
subject and reference legs was proven to be planar through both shear-plate interferometric analysis ( Malacara , pp 105-48) and by observing the...London: Cam- bridge University Press, 1969 Malacara . Daniel, ed. Optical Shop Testing. New York: John Wiley and Sons, 1978. Marathay, Arvind S
Viswanath, Satish; Palumbo, Daniel; Chappelow, Jonathan; Patel, Pratik; Bloch, B. Nicholas; Rofsky, Neil; Lenkinski, Robert; Genega, Elizabeth; Madabhushi, Anant
2011-03-01
In magnetic resonance imaging (MRI), intensity inhomogeneity refers to an acquisition artifact which introduces a non-linear variation in the signal intensities within the image. Intensity inhomogeneity is known to significantly affect computerized analysis of MRI data (such as automated segmentation or classification procedures), hence requiring the application of bias field correction (BFC) algorithms to account for this artifact. Quantitative evaluation of BFC schemes is typically performed using generalized intensity-based measures (percent coefficient of variation, %CV ) or information-theoretic measures (entropy). While some investigators have previously empirically compared BFC schemes in the context of different domains (using changes in %CV and entropy to quantify improvements), no consensus has emerged as to the best BFC scheme for any given application. The motivation for this work is that the choice of a BFC scheme for a given application should be dictated by application-specific measures rather than ad hoc measures such as entropy and %CV. In this paper, we have attempted to address the problem of determining an optimal BFC algorithm in the context of a computer-aided diagnosis (CAD) scheme for prostate cancer (CaP) detection from T2-weighted (T2w) MRI. One goal of this work is to identify a BFC algorithm that will maximize the CaP classification accuracy (measured in terms of the area under the ROC curve or AUC). A secondary aim of our work is to determine whether measures such as %CV and entropy are correlated with a classifier-based objective measure (AUC). Determining the presence or absence of these correlations is important to understand whether domain independent BFC performance measures such as %CV , entropy should be used to identify the optimal BFC scheme for any given application. In order to answer these questions, we quantitatively compared 3 different popular BFC algorithms on a cohort of 10 clinical 3 Tesla prostate T2w MRI datasets
He, Xiaojun; Ma, Haotong; Luo, Chuanxin
2016-10-01
The optical multi-aperture imaging system is an effective way to magnify the aperture and increase the resolution of telescope optical system, the difficulty of which lies in detecting and correcting of co-phase error. This paper presents a method based on stochastic parallel gradient decent algorithm (SPGD) to correct the co-phase error. Compared with the current method, SPGD method can avoid detecting the co-phase error. This paper analyzed the influence of piston error and tilt error on image quality based on double-aperture imaging system, introduced the basic principle of SPGD algorithm, and discuss the influence of SPGD algorithm's key parameters (the gain coefficient and the disturbance amplitude) on error control performance. The results show that SPGD can efficiently correct the co-phase error. The convergence speed of the SPGD algorithm is improved with the increase of gain coefficient and disturbance amplitude, but the stability of the algorithm reduced. The adaptive gain coefficient can solve this problem appropriately. This paper's results can provide the theoretical reference for the co-phase error correction of the multi-aperture imaging system.
Small, Matthew W; Sanchez, Sergio I; Menard, Laurent D; Kang, Joo H; Frenkel, Anatoly I; Nuzzo, Ralph G
2011-03-16
This study describes a prototypical, bimetallic heterogeneous catalyst: compositionally well-defined Ir-Pt nanoclusters with sizes in the range of 1-2 nm supported on γ-Al(2)O(3). Deposition of the molecular bimetallic cluster [Ir(3)Pt(3)(μ-CO)(3)(CO)(3)(η-C(5)Me(5))(3)] on γ-Al(2)O(3), and its subsequent reduction with hydrogen, provides highly dispersed supported bimetallic Ir-Pt nanoparticles. Using spherical aberration-corrected scanning transmission electron microscopy (C(s)-STEM) and theoretical modeling of synchrotron-based X-ray absorption spectroscopy (XAS) measurements, our studies provide unambiguous structural assignments for this model catalytic system. The atomic resolution C(s)-STEM images reveal strong and specific lattice-directed strains in the clusters that follow local bonding configurations of the γ-Al(2)O(3) support. Combined nanobeam diffraction (NBD) and high-resolution transmission electron microscopy (HRTEM) data suggest the polycrystalline γ-Al(2)O(3) support material predominantly exposes (001) and (011) surface planes (ones commensurate with the zone axis orientations frequently exhibited by the bimetallic clusters). The data reveal that the supported bimetallic clusters exhibit complex patterns of structural dynamics, ones evidencing perturbations of an underlying oblate/hemispherical cuboctahedral cluster-core geometry with cores that are enriched in Ir (a result consistent with models based on surface energetics, which favor an ambient cluster termination by Pt) due to the dynamical responses of the M-M bonding to the specifics of the adsorbate and metal-support interactions. Taken together, the data demonstrate that strong temperature-dependent charge-transfer effects occur that are likely mediated variably by the cluster-support, cluster-adsorbate, and intermetallic bonding interactions.
Huang, Rong; Limburg, Karin; Rohtla, Mehis
2017-05-01
X-ray fluorescence computed tomography is often used to measure trace element distributions within low-Z samples, using algorithms capable of X-ray absorption correction when sample self-absorption is not negligible. Its reconstruction is more complicated compared to transmission tomography, and therefore not widely used. We describe in this paper a very practical iterative method that uses widely available transmission tomography reconstruction software for fluorescence tomography. With this method, sample self-absorption can be corrected not only for the absorption within the measured layer but also for the absorption by material beyond that layer. By combining tomography with analysis for scanning X-ray fluorescence microscopy, absolute concentrations of trace elements can be obtained. By using widely shared software, we not only minimized the coding, took advantage of computing efficiency of fast Fourier transform in transmission tomography software, but also thereby accessed well-developed data processing tools coming with well-known and reliable software packages. The convergence of the iterations was also carefully studied for fluorescence of different attenuation lengths. As an example, fish eye lenses could provide valuable information about fish life-history and endured environmental conditions. Given the lens's spherical shape and sometimes the short distance from sample to detector for detecting low concentration trace elements, its tomography data are affected by absorption related to material beyond the measured layer but can be reconstructed well with our method. Fish eye lens tomography results are compared with sliced lens 2D fluorescence mapping with good agreement, and with tomography providing better spatial resolution.
Generalized pupil aberrations of optical imaging systems
Elazhary, Tamer T.
In this dissertation fully general conditions are presented to correct linear and quadratic field dependent aberrations that do not use any symmetry. They accurately predict the change in imaging aberrations in the presence of lower order field dependent aberrations. The definitions of the image, object, and coordinate system are completely arbitrary. These conditions are derived using a differential operator on the scalar wavefront function. The relationships are verified using ray trace simulations of a number of systems with varying degrees of complexity. The math is shown to be extendable to provide full expansion of the scalar aberration function about field. These conditions are used to guide the design of imaging systems starting with only paraxial surface patches, then growing freeform surfaces that maintain the analytic conditions satisfied for each point in the pupil. Two methods are proposed for the design of axisymmetric and plane symmetric optical imaging systems. Design examples are presented as a proof of the concept.
Sensing Phase Aberrations behind Lyot Coronagraphs
Sivaramakrishnan, Anand; Soummer, Rémi; Pueyo, Laurent; Wallace, J. Kent; Shao, Michael
2008-11-01
Direct detection of young extrasolar planets orbiting nearby stars can be accomplished from the ground with extreme adaptive optics and coronagraphy in the near-infrared, as long as this combination can provide an image with a dynamic range of 107 after the data are processed. Slowly varying speckles due to residual phase aberrations that are not measured by the primary wave-front sensor are the primary obstacle to achieving such a dynamic range. In particular, non-common optical path aberrations occurring between the wave-front sensor and the coronagraphic occulting spot degrade performance the most. We analyze the passage of both low and high spatial frequency phase ripples, as well as low-order Zernike aberrations, through an apodized pupil Lyot coronagraph in order to demonstrate the way coronagraphic filtering affects various aberrations. We derive the coronagraphically induced cutoff frequency of the filtering and estimate coronagraphic contrast losses due to low-order Zernike aberrations: tilt, astigmatism, defocus, coma, and spherical aberration. Such slowly varying path errors can be measured behind a coronagraph and corrected by a slowly updated optical path delay precompensation or offset asserted on the wave front by the adaptive optics (AO) system. We suggest ways of measuring and correcting all but the lowest spatial frequency aberrations using Lyot plane wave-front data, in spite of the complex interaction between the coronagraph and those mid-spatial frequency aberrations that cause image plane speckles near the coronagraphic focal plane mask occulter's edge. This investigation provides guidance for next-generation coronagraphic instruments currently under construction.
Finley, Jahahreeh
2015-09-01
AMPK, a master regulator of cellular metabolism which has been shown to activate PKC-theta (θ) and is essential for T cell activation, may modulate the splicing activities of SRp55 as well as enhance a p32-mediated inhibition of ASF/SF2-induced alternative splicing, potentially correcting aberrant alternative splicing in the LMNA gene and reactivating latent viral HIV-1 reservoirs. Moreover, similar epigenetic modifications and cell cycle regulators also characterize the analogous stages of premature senescence in progeroid cells and latency in HIV-1 infected T cells. AMPK-activating compounds including metformin and resveratrol may thus embody a novel treatment paradigm linking the pathophysiology of HGPS with that of HIV-1 latency.
MAPCLASS a code to optimize high order aberrations
Tomás, R
2006-01-01
MAPCLASS is a code written in PYTHON conceived to optimize the non-linear aberrations of the Final Focus System of CLIC. MAPCLASS calls MADX-PTC to obtain the map coefficients and uses optimization algorithms like the Simplex to compensate the high order aberrations.
Geometrical Aberration Suppression for Large Aperture Sub-THz Lenses
Rachon, M.; Liebert, K.; Siemion, A.; Bomba, J.; Sobczyk, A.; Knap, W.; Coquillat, D.; Suszek, J.; Sypek, M.
2017-03-01
Advanced THz setups require high performance optical elements with large numerical apertures and small focal lengths. This is due to the high absorption of humid air and relatively low efficiency of commercially available detectors. Here, we propose a new type of double-sided sub-THz diffractive optical element with suppressed geometrical aberration for narrowband applications (0.3 THz). One side of the element is designed as thin structure in non-paraxial approach which is the exact method, but only for ideally flat elements. The second side will compensate phase distribution differences between ideal thin structure and real volume one. The computer-aided optimization algorithm is performed to design an additional phase distribution of correcting layer assuming volume designing of the first side of the element. The experimental evaluation of the proposed diffractive component created by 3D printing technique shows almost two times larger performance in comparison with uncorrected basic diffractive lens.
Geometrical Aberration Suppression for Large Aperture Sub-THz Lenses
Rachon, M.; Liebert, K.; Siemion, A.; Bomba, J.; Sobczyk, A.; Knap, W.; Coquillat, D.; Suszek, J.; Sypek, M.
2016-11-01
Advanced THz setups require high performance optical elements with large numerical apertures and small focal lengths. This is due to the high absorption of humid air and relatively low efficiency of commercially available detectors. Here, we propose a new type of double-sided sub-THz diffractive optical element with suppressed geometrical aberration for narrowband applications (0.3 THz). One side of the element is designed as thin structure in non-paraxial approach which is the exact method, but only for ideally flat elements. The second side will compensate phase distribution differences between ideal thin structure and real volume one. The computer-aided optimization algorithm is performed to design an additional phase distribution of correcting layer assuming volume designing of the first side of the element. The experimental evaluation of the proposed diffractive component created by 3D printing technique shows almost two times larger performance in comparison with uncorrected basic diffractive lens.
Slot Thing, Rune; Bernchou, Uffe; Mainegra-Hing, Ernesto;
2013-01-01
Abstract Purpose. Cone beam computed tomography (CBCT) image quality is limited by scattered photons. Monte Carlo (MC) simulations provide the ability of predicting the patient-specific scatter contamination in clinical CBCT imaging. Lengthy simulations prevent MC-based scatter correction from...... and pelvis scan were simulated within 2% statistical uncertainty in two hours per scan. Within the same time, the ray tracing algorithm provided the primary signal for each of the projections. Thus, all the data needed for MC-based scatter correction in clinical CBCT imaging was obtained within two hours per...
Wide-angle chromatic aberration corrector for the human eye.
Benny, Yael; Manzanera, Silvestre; Prieto, Pedro M; Ribak, Erez N; Artal, Pablo
2007-06-01
The human eye is affected by large chromatic aberration. This may limit vision and makes it difficult to see fine retinal details in ophthalmoscopy. We designed and built a two-triplet system for correcting the average longitudinal chromatic aberration of the eye while keeping a reasonably wide field of view. Measurements in real eyes were conducted to examine the level and optical quality of the correction. We also performed some tests to evaluate the effect of the corrector on visual performance.
Jitra Kriangkum
Full Text Available Aberrant pre-mRNA splice variants of hyaluronan synthase 1 (HAS1 have been identified in malignant cells from cancer patients. Bioinformatic analysis suggests that intronic sequence changes can underlie aberrant splicing. Deletions and mutations were introduced into HAS1 minigene constructs to identify regions that can influence aberrant intronic splicing, comparing the splicing pattern in transfectants with that in multiple myeloma (MM patients. Introduced genetic variations in introns 3 and 4 of HAS1 as shown here can promote aberrant splicing of the type detected in malignant cells from MM patients. HAS1Vd is a novel intronic splice variant first identified here. HAS1Vb, an intronic splice variant previously identified in patients, skips exon 4 and utilizes the same intron 4 alternative 3'splice site as HAS1Vd. For transfected constructs with unaltered introns 3 and 4, HAS1Vd transcripts are readily detectable, frequently to the exclusion of HAS1Vb. In contrast, in MM patients, HAS1Vb is more frequent than HAS1Vd. In the HAS1 minigene, combining deletion in intron 4 with mutations in intron 3 leads to a shift from HAS1Vd expression to HAS1Vb expression. The upregulation of aberrant splicing, exemplified here by the expression of HAS1Vb, is shown here to be influenced by multiple genetic changes in intronic sequences. For HAS1Vb, this includes enhanced exon 4 skipping and increased usage of alternative 3' splice sites. Thus, the combination of introduced mutations in HAS1 intron3 with introduced deletions in HAS1 intron 4 promoted a shift to an aberrant splicing pattern previously shown to be clinically significant. Most MM patients harbor genetic variations in intron 4, and as shown here, nearly half harbor recurrent mutations in HAS1 intron 3. Our work suggests that aberrant intronic HAS1 splicing in MM patients may rely on intronic HAS1 deletions and mutations that are frequent in MM patients but absent from healthy donors.
Inaniwa, T.; Kanematsu, N.; Sato, S.; Kohno, R.
2016-01-01
In treatment planning for proton radiotherapy, the dose measured in water is applied to the patient dose calculation with density scaling by stopping power ratio {ρ\\text{S}} . Since the body tissues are chemically different from water, this approximation may cause dose calculation errors, especially due to differences in nuclear interactions. We proposed and validated an algorithm for correcting these errors. The dose in water is decomposed into three constituents according to the physical interactions of protons in water: the dose from primary protons continuously slowing down by electromagnetic interactions, the dose from protons scattered by elastic and/or inelastic interactions, and the dose resulting from nonelastic interactions. The proportions of the three dose constituents differ between body tissues and water. We determine correction factors for the proportion of dose constituents with Monte Carlo simulations in various standard body tissues, and formulated them as functions of their {ρ\\text{S}} for patient dose calculation. The influence of nuclear interactions on dose was assessed by comparing the Monte Carlo simulated dose and the uncorrected dose in common phantom materials. The influence around the Bragg peak amounted to -6% for polytetrafluoroethylene and 0.3% for polyethylene. The validity of the correction method was confirmed by comparing the simulated and corrected doses in the materials. The deviation was below 0.8% for all materials. The accuracy of the correction factors derived with Monte Carlo simulations was separately verified through irradiation experiments with a 235 MeV proton beam using common phantom materials. The corrected doses agreed with the measurements within 0.4% for all materials except graphite. The influence on tumor dose was assessed in a prostate case. The dose reduction in the tumor was below 0.5%. Our results verify that this algorithm is practical and accurate for proton radiotherapy treatment planning, and
Backman, J.; Virkkula, A.; Vakkari, V.; Beukes, J. P.; Van Zyl, P. G.; Josipovic, M.; Piketh, S.; Tiitta, P.; Chiloane, K.; Petäjä, T.; Kulmala, M.; Laakso, L.
2014-12-01
Absorption Ångström exponents (AAEs) calculated from filter-based absorption measurements are often used to give information on the origin of the ambient aerosol, for example, to distinguish between urban pollution and biomass burning aerosol. Filter-based absorption measurements are widely used and are common at aerosol monitoring stations globally. Several correction algorithms are used to account for artefacts associated with filter-based absorption techniques. These algorithms are of profound importance when determining the absolute amount of absorption by the aerosol. However, this study shows that there are substantial differences between the AAEs calculated from these corrections. Depending on the used correction, AAEs can change by as much as 46%. The study also highlights that the difference between AAEs calculated using different corrections can lead to conflicting conclusions on the type of aerosol when using the same data set. The AAE ranged between 1.17 for non-corrected data to 1.96 for the correction that gave the greatest values. Furthermore, the study implies that the AAEs reported for a site depend on at which filter transmittance the filter is changed. In this work, the AAEs were calculated from data measured with a three-wavelength particle soot absorption photometer (PSAP) at Elandsfontein on the South African Highveld for 23 months. The sample air of the PSAP was diluted to prolong filter change intervals, by a factor of 15. The correlation coefficient between the dilution-corrected PSAP and a non-diluted Multi-Angle Absorption Photometer (MAAP) was 0.9. Thus, the study also shows that the applicability of the PSAP can be extended to remote sites that are not often visited or suffer from high levels of pollution.
Kotrri, Gynter; Fusch, Gerhard; Kwan, Celia; Choi, Dasol; Choi, Arum; Al Kafi, Nisreen; Rochow, Niels; Fusch, Christoph
2016-02-26
Commercial infrared (IR) milk analyzers are being increasingly used in research settings for the macronutrient measurement of breast milk (BM) prior to its target fortification. These devices, however, may not provide reliable measurement if not properly calibrated. In the current study, we tested a correction algorithm for a Near-IR milk analyzer (Unity SpectraStar, Brookfield, CT, USA) for fat and protein measurements, and examined the effect of pasteurization on the IR matrix and the stability of fat, protein, and lactose. Measurement values generated through Near-IR analysis were compared against those obtained through chemical reference methods to test the correction algorithm for the Near-IR milk analyzer. Macronutrient levels were compared between unpasteurized and pasteurized milk samples to determine the effect of pasteurization on macronutrient stability. The correction algorithm generated for our device was found to be valid for unpasteurized and pasteurized BM. Pasteurization had no effect on the macronutrient levels and the IR matrix of BM. These results show that fat and protein content can be accurately measured and monitored for unpasteurized and pasteurized BM. Of additional importance is the implication that donated human milk, generally low in protein content, has the potential to be target fortified.
Fast algorithms for generating binary holograms
Stuart, Dustin; Kuhn, Axel
2014-01-01
We describe three algorithms for generating binary-valued holograms. Our methods are optimised for producing large arrays of tightly focussed optical tweezers for trapping particles. Binary-valued holograms allow us to use a digital mirror device (DMD) as the display element, which is much faster than other alternatives. We describe how our binary amplitude holograms can be used to correct for phase errors caused by optical aberrations. Furthermore, we compare the speed and accuracy of the algorithms for both periodic and arbitrary arrangements of traps, which allows one to choose the ideal scheme depending on the circumstances.
J. Backman
2014-09-01
Full Text Available Absorption Ångstrom exponents (AAE calculated from filter-based absorption measurements are often used to give information on the origin of the ambient aerosol, for example to distinguish between urban pollution and biomass burning aerosol. Filter-based absorption measurements are a widely used method and are commonly used at aerosol monitoring stations globally. Several correction algorithms are used to account for the artifacts associated with filter-based absorption techniques. These algorithms are of profound importance when determining the absolute amount of absorption by the aerosol. However, this study shows that there are significant differences between the AAEs calculated from these corrections. The study also shows that the difference between AAEs calculated using different corrections can lead to conflicting conclusions on the type of aerosol for the same data set. In this work the AAEs were calculated from data measured with a three-wavelength Particle Soot Absorption Photometer (PSAP at Elandsfontein on deployed on the South African Highveld for 23 months. The sample air of the PSAP was diluted to prolong filter change intervals. The dilution-corrected PSAP showed a good agreement with a non-diluted MAAP. Thus, the study also shows that the applicability of the PSAP can be extended to remote sites are not often visited or suffer from high levels of pollution.
Backman, J.; Virkkula, A.; Vakkari, V.; Beukes, J. P.; Van Zyl, P.; Josipovic, M.; Piketh, S.; Tiitta, P.; Chiloane, K.; Petäjä, T.; Kulmala, M.; Laakso, L.
2014-09-01
Absorption Ångstrom exponents (AAE) calculated from filter-based absorption measurements are often used to give information on the origin of the ambient aerosol, for example to distinguish between urban pollution and biomass burning aerosol. Filter-based absorption measurements are a widely used method and are commonly used at aerosol monitoring stations globally. Several correction algorithms are used to account for the artifacts associated with filter-based absorption techniques. These algorithms are of profound importance when determining the absolute amount of absorption by the aerosol. However, this study shows that there are significant differences between the AAEs calculated from these corrections. The study also shows that the difference between AAEs calculated using different corrections can lead to conflicting conclusions on the type of aerosol for the same data set. In this work the AAEs were calculated from data measured with a three-wavelength Particle Soot Absorption Photometer (PSAP) at Elandsfontein on deployed on the South African Highveld for 23 months. The sample air of the PSAP was diluted to prolong filter change intervals. The dilution-corrected PSAP showed a good agreement with a non-diluted MAAP. Thus, the study also shows that the applicability of the PSAP can be extended to remote sites are not often visited or suffer from high levels of pollution.
Study of ocular aberrations with age.
Athaide, Helaine Vinche Zampar; Campos, Mauro; Costa, Charles
2009-01-01
Aging has various effects on visual system. Vision deteriorate, contrast sensitivity decreases and ocular aberrations apparently make the optical quality worse across the years. To prospective evaluate ocular aberrations along the ages. Three hundred and fifteen patients were examined, 155 were male (39.36%) and 160 were female (60.63%). Ages ranged from 5 to 64 year-old, the study was performed from February to November, 2004. Patients were divided into 4 age-groups according to IBGE (Instituto Brasileiro de Geografia e Estatística) classification: 68 patients from 5 to 14 year-old, 55 patients from 15 to 24 year-old, 116 from 25 to 44 year-old and 76 from 45 to 67 year-old. All patients had the following characteristics: best corrected visual acuity > 20/25, emmetropia or spherical equivalent < 3.50 SD, refractive astigmatism < 1.75 CD on cycloplegic refraction, normal ophthalmologic exam and no previous ocular surgeries. This protocol was approved by Federal University of São Paulo Institutional Review Board. Total optical aberrations were measured by H-S sensor LadarWave Custom Cornea Wavefront System (Alcon Laboratories Inc, Orlando, FLA, USA) and were statistically analysed. Corneal aberrations were calculated using CT-View software Version 6.89 (Sarver and Associates, Celebration, FL, USA). Lens aberrations were calculated by subtraction. High-order (0.32 e 0.48 microm) and ocular spherical aberrations (0.02 e 0.26 microm) increased respectively in child and middle age groups. High order (0.27 microm) and corneal spherical aberrations (0.05 microm) did not show changes with age. Lens showed a statistically significant spherical aberration increase (from -0.02 to 0.22 microm). Vertical (from 0.10 to -0.07 microm) and horizontal coma (from 0.01 to -0.12 microm) presented progressively negative values with aging. High-order and spherical aberrations increased with age due to lens contribution. The cornea did not affect significantly changes observed on ocular
V. S. Kudryashov
2016-01-01
Full Text Available The article is devoted to the development of a correction control algorithm by temperature mode of a periodic rubber mixing process for JSC "Voronezh tire plant". The algorithm is designed to perform in the main controller a section of rubber mixing Siemens S7 CPU319F-3 PN/DP, which forms tasks for the local temperature controllers HESCH HE086 and Jumo dTRON304, operating by tempering stations. To compile the algorithm was performed a systematic analysis of rubber mixing process as an object of control and was developed a mathematical model of the process based on the heat balance equations describing the processes of heat transfer through the walls of technological devices, the change of coolant temperature and the temperature of the rubber compound mixing until discharge from the mixer chamber. Due to the complexity and nonlinearity of the control object – Rubber mixers and the availability of methods and a wide experience of this device control in an industrial environment, a correction algorithm is implemented on the basis of an artificial single-layer neural network and it provides the correction of tasks for local controllers on the cooling water temperature and air temperature in the workshop, which may vary considerably depending on the time of the year, and during prolonged operation of the equipment or its downtime. Tempering stations control is carried out by changing the flow of cold water from the cooler and on/off control of the heating elements. The analysis of the model experiments results and practical research at the main controller programming in the STEP 7 environment at the enterprise showed a decrease in the mixing time for different types of rubbers by reducing of heat transfer process control error.
Improved Kalman Filtering Algorithm in Non-Uniformity Correction%改进的卡尔曼滤波非均匀性校正算法
李晶; 朱斌; 郭立新; 龙波; 王小珂
2012-01-01
针对基于卡尔曼滤波(Kalman filtering,KF)的红外焦平面非均匀性校正算法的计算量和存储量较大,不利于实时性校正的缺点,提出一种改进的卡尔曼滤波非均匀性校正算法.该算法通过线性递归滤波器修正了观测方程,用每一帧块图像的统计均值来代替卡尔曼滤波校正算法中的观测矩阵,使增益矩阵得到简化.Matlab仿真实验结果证明:该算法的校正效果与传统的卡尔曼滤波校正算法相当,但大大减少了计算量和存储空间.%Aiming at the big computational complexity and memory requirement of infrared focal plane non-uniformity correction algorithm based on Kalman filtering, it cannot realize real-time correction shortage, an improved Kalman filtering non-uniformity correction algorithm is given. The proposed algorithm modified the observation model by applying linear recursion filter that the observation was instead of the mean value of every block image, then the matrix will be simplified. The simulation of Matlab proves that the computational complexity and memory requirements are significantly reduced, while the correction result is similar.
The Aberrant Coronary Artery - The Management Approach.
King, Nina-Marie; Tian, David D; Munkholm-Larsen, Stine; Buttar, Sana N; Chow, Vincent; Yan, Tristan
2017-07-03
An aberrant coronary artery is a rare clinical occurrence with an incidence of 0.05-1.2%. Often it is an incidental finding detected on coronary angiography or at autopsy. However, symptomatic patients can experience angina, arrhythmia, sudden death or non-specific symptoms such as dyspnoea and syncope. At present, there are no guidelines or dedicated studies assessing the treatment of an aberrant coronary artery leaving management options for these patients controversial. Selected international cardiothoracic surgeons were surveyed electronically in November 2016 to determine whether consensus exists on different management aspects for patients with an aberrant coronary artery arising from the contralateral sinus with an interarterial course. For asymptomatic patients with either an aberrant left main coronary artery (ALMCA) arising from the contralateral sinus or an aberrant right main coronary artery (ARMCA) arising from the contralateral sinus, there was no consensus on surgical correction of the anomaly. If myocardial ischaemia was demonstrated on either coronary angiography with fractional flow reserve measurements and/or stress myocardial perfusion scan, surgical correction was the consensus between the surveyed surgeons. If surgery was deemed appropriate, coronary artery bypass surgery utilising the internal mammary artery was marginally preferred by the respondents in patients with an ALMCA whilst unroofing of the coronary ostium was preferred in patients with an ARMCA. Although no consensus was reached, a large proportion of respondents would not treat a patient over the age of 30 years differently compared to those under 30 years old. For symptomatic patients or if myocardial ischaemia is demonstrated on either coronary angiography with fractional flow reserve measurements and/or stress myocardial perfusion scan, surgical correction is indicated. Copyright © 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the
Maltz, Jonathan S; Gangadharan, Bijumon; Bose, Supratik; Hristov, Dimitre H; Faddegon, Bruce A; Paidi, Ajay; Bani-Hashemi, Ali R
2008-12-01
Quantitative reconstruction of cone beam X-ray computed tomography (CT) datasets requires accurate modeling of scatter, beam-hardening, beam profile, and detector response. Typically, commercial imaging systems use fast empirical corrections that are designed to reduce visible artifacts due to incomplete modeling of the image formation process. In contrast, Monte Carlo (MC) methods are much more accurate but are relatively slow. Scatter kernel superposition (SKS) methods offer a balance between accuracy and computational practicality. We show how a single SKS algorithm can be employed to correct both kilovoltage (kV) energy (diagnostic) and megavoltage (MV) energy (treatment) X-ray images. Using MC models of kV and MV imaging systems, we map intensities recorded on an amorphous silicon flat panel detector to water-equivalent thicknesses (WETs). Scattergrams are derived from acquired projection images using scatter kernels indexed by the local WET values and are then iteratively refined using a scatter magnitude bounding scheme that allows the algorithm to accommodate the very high scatter-to-primary ratios encountered in kV imaging. The algorithm recovers radiological thicknesses to within 9% of the true value at both kV and megavolt energies. Nonuniformity in CT reconstructions of homogeneous phantoms is reduced by an average of 76% over a wide range of beam energies and phantom geometries.
Combined Nonuniformity Correction Algorithm of Infrared Focal Plane Arrays%红外焦平面联合非均匀性校正算法
洪闻青; 杨南生; 王晓东; 苏俊波; 苏兰; 胡志斌
2011-01-01
分别分析了红外焦平面阵列(IRFPA)基于定标的非均匀性校正(NUC)算法和基于场景的NUC算法的优势和问题.在此基础上提出了联合NUC算法,其中利用基于定标的两点校正法来初步消除探测器的非均匀性,然后再采用基于场景的时域高通校正法和新型自适应滤波校正法来抑制探测器非均匀性参数漂移的影响,同时减弱系统噪声对成像质量的破坏.实验结果表明,与两点法、时域高通法以及传统自适应滤波法等具有较大工程应用价值的NUC算法相比,联合NUC算法具有稳定而且性能更为优良的校正效果.%The advantages and disadvantages in nonuniformity correction (NUC) algorithms based on calibration and scene of infrared focal plane arrays (IRFPA) are analysed separately. The combined NUC algorithm is presented.Two-point NUC algorithm based on calibration is adopted to remove the nonuniformity of the detector simply. The influences of detectors' NUC parameters which will change with time are weakened by using the scene-based temporal high-pass filter algorithm and new-style adaptive filter algorithm. The disadvantages for image quality introduced by ynoises are weakened too. The experimental results show that the combined NUC algorithm is more stable and better than some NUC algorithms with great value in project applications, such as two point NUC algorithm, temporal highpass filter NUC algorithm and former adaptive filter NUC algorithm.
Wang, Tianren
2015-01-01
This paper presents a numerical study on a fast marching method based back projection reconstruction algorithm for photoacoustic tomography in heterogeneous media. Transcranial imaging is used here as a case study. To correct for the phase aberration from the heterogeneity (i.e., skull), the fast marching method is adopted to compute the phase delay based on the known speed of sound distribution, and the phase delay is taken into account by the back projection algorithm for more accurate reconstructions. It is shown that the proposed algorithm is more accurate than the conventional back projection algorithm, but slightly less accurate than the time reversal algorithm particularly in the area close to the skull. However, the image reconstruction time for the proposed algorithm can be as little as 124 ms when implemented by a GPU (512 sensors, 21323 pixels reconstructed), which is two orders of magnitude faster than the time reversal reconstruction. The proposed algorithm, therefore, not only corrects for the p...
S. U. Khan
2014-01-01
Full Text Available Three issues regarding sensor failure at any position in the antenna array are discussed. We assume that sensor position is known. The issues include raise in sidelobe levels, displacement of nulls from their original positions, and diminishing of null depth. The required null depth is achieved by making the weight of symmetrical complement sensor passive. A hybrid method based on memetic computing algorithm is proposed. The hybrid method combines the cultural algorithm with differential evolution (CADE which is used for the reduction of sidelobe levels and placement of nulls at their original positions. Fitness function is used to minimize the error between the desired and estimated beam patterns along with null constraints. Simulation results for various scenarios have been given to exhibit the validity and performance of the proposed algorithm.
Ying XU; Chang-fu ZONG; Hsiao-hsiang NA; Lei LIU
2009-01-01
To improve the handling performance of a steer-by-wire (SBW) vehicle, a series of control logics are proposed. Firstly,an algorithm for enhancing the maneuvering in steady-state cornering is presented. On this basis, two categories of control strategies are used to dynamically correct and compensate the transient state steering responses and vehicle behaviors. Simulator tests including subjective evaluations and virtual field tests are both conducted to make comprehensive investigations on the series of control logics. The subjective evaluations demonstrate that the SBW vehicle with a specifically selected value of steering sensitivity tends to be more desirable for driving than a conventional one in which a fixed steering ratio exists. The virtual field tests indicate that the control strategies for dynamical correction and compensation could effectively improve the handling performances of an SBW vehicle by reducing the work load of drivers, enhancing the track-holding performance, and improving steering response properties.
Effects of aberrations in spatiotemporal focusing of ultrashort laser pulses.
Sun, Bangshan; Salter, Patrick S; Booth, Martin J
2014-04-01
Spatiotemporal focusing, or simultaneous spatial and temporal focusing (SSTF), has already been adopted for various applications in microscopy, photoactivation for biological studies, and laser fabrication. We investigate the effects of aberrations on focus formation in SSTF, in particular, the effects of phase aberrations related to low-order Zernike modes and a refractive index mismatch between the immersion medium and sample. By considering a line focus, we are able to draw direct comparison between the performance of SSTF and conventional spatial focusing (SF). Wide-field SSTF is also investigated and is found to be much more robust to aberrations than either line SSTF or SF. These results show the sensitivity of certain focusing methods to specific aberrations, and can inform on the necessity and benefit of aberration correction.
Validation and Analysis of Water Column Correction Algorithm at Sanya Bay%水体校正模型在三亚湾的验证及分析
杨超宇; 杨顶田; 叶海彬; 曹文熙
2011-01-01
水体校正一直是光学浅水遥感检测中的重点难题.为了提高三亚湾底质遥感监测精度,分别采用理想水体光辐射分布和Christian模型剔除水体信号的影响,尝试从水面之下遥感反射率信号中提取其底质光谱反射率值.结果表明,两种模型模拟结果差异较大,其模拟与实测值的相关性分别是0.93和0.26.经分析认为Christian模型在三亚湾湾内水域失效的这一结果与三亚湾光学浅水和光学深水的差异性相关.三亚湾湾内水域光学性质复杂,光学参数随着地理坐标位置变化较大,即使在光学浅水水域内的邻近站点,其衰减系数也是具有较大差异的.因而,Christian的模型在此区域很难发挥出优势.%Water column correction has been a substantial challenge for remote sensing. In order to improve the accuracy of coastal ocean monitoring where optical properties are complex, optical property of shallow water at Sanya Bay and the suitable water column correction algorithms were studies in the present paper. The authors extracted the bottom reflectance without water column effects by using a water column correction algorithm which is based on the simulation of the underwater light field in idealized water. And we compared the results which were calculated by the model and Christian's model respectively. Based on a detailed analysis, we concluded that: Because the optical properties of Sanya Bay are complex and vary greatly with location,Christian's model lost its advantage in the area. Conversely, the bottom reflectance calculating by the algorithm based on the simulation of the underwater light field in idealized water agreed well with in situ measured bottom reflectance, although the reflectance was lower than in situ measured reflectance value between 400 and 500 nm. So, it is reasonable to extract bottom information by using the water column correction algorithm in local bay area where optical properties are complex.
Mei, Alessandro; Manzo, Ciro; Petracchini, Francesco; Bassani, Cristiana
2016-04-01
Remote sensing techniques allow to estimate vegetation parameters related to large areas for forest health evaluation and biomass estimation. Moreover, the parametrization of specific indices such as Normalized Difference Vegetation Index (NDVI) allows to study biogeochemical cycles and radiative energy transfer processes between soil/vegetation and atmosphere. This paper focuses on the evaluation of vegetation cover analysis in Leonessa Municipality, Latium Region (Italy) by the use of 2015 Landsat 8 applying the OLI@CRI (OLI ATmospherically Corrected Reflectance Imagery) algorithm developed following the procedure described in Bassani et al. 2015. The OLI@CRI is based on 6SV radiative transfer model (Kotchenova et al., 2006) ables to simulate the radiative field in the atmosphere-earth coupled system. NDVI was derived from the OLI corrected image. This index, widely used for biomass estimation and vegetation analysis cover, considers the sensor channels falling in the near infrared and red spectral regions which are sensitive to chlorophyll absorption and cell structure. The retrieved product was then spatially resampled at MODIS image resolution and then validated by the NDVI of MODIS considered as reference. The physically-based OLI@CRI algorithm also provides the incident solar radiation at ground at the acquisition time by 6SV simulation. Thus, the OLI@CRI algorithm completes the remote sensing dataset required for a comprehensive analysis of the sub-regional biomass production by using data of the new generation remote sensing sensor and an atmospheric radiative transfer model. If the OLI@CRI algorithm is applied to a temporal series of OLI data, the influence of the solar radiation on the above-ground vegetation can be analysed as well as vegetation index variation.
Mathiesen, Elisabeth R; Christensen, Ann-Birgitte L; Hellmuth, Ellinor
2002-01-01
Poor glycemic control is often a serious clinical problem during glucocorticoid treatment for fetal lung maturation in pregnant women with diabetes. An algorithm for improved subcutaneous insulin treatment during glucocorticoid treatment in insulin-dependent diabetic women was developed and tested....
Anisoplanatism in adaptive optics systems due to pupil aberrations
Bauman, B
2005-08-01
Adaptive optics systems typically include an optical relay that simultaneously images the science field to be corrected and also a set of pupil planes conjugate to the deformable mirror of the system. Often, in the optical spaces where DM's are placed, the pupils are aberrated, leading to a displacement and/or distortion of the pupil that varies according to field position--producing a type of anisoplanatism, i.e., a degradation of the AO correction with field angle. The pupil aberration phenomenon is described and expressed in terms of Seidel aberrations. An expression for anisoplanatism as a function of pupil distortion is derived, an example of an off-axis parabola is given, and a convenient method for controlling pupil-aberration-generated anisoplanatism is proposed.
Multiplexed aberration measurement for deep tissue imaging in vivo
Wang, Chen; Liu, Rui; Milkie, Daniel E; Sun, Wenzhi; Tan, Zhongchao; Kerlin, Aaron; Chen, Tsai-Wen; Kim, Douglas S.; Ji, Na
2014-01-01
We describe a multiplexed aberration measurement method that modulates the intensity or phase of light rays at multiple pupil segments in parallel to determine their phase gradients. Applicable to fluorescent-protein-labeled structures of arbitrary complexity, it allows us to obtain diffraction-limited resolution in various samples in vivo. For the strongly scattering mouse brain, a single aberration correction improves structural and functional imaging of fine neuronal processes over a large...
Multiplexed aberration measurement for deep tissue imaging in vivo
Wang, Chen; Liu, Rui; Milkie, Daniel E.; Sun, Wenzhi; Tan, Zhongchao; Kerlin, Aaron; Chen, Tsai-Wen; Kim, Douglas S.; Ji, Na
2014-01-01
We describe a multiplexed aberration measurement method that modulates the intensity or phase of light rays at multiple pupil segments in parallel to determine their phase gradients. Applicable to fluorescent-protein-labeled structures of arbitrary complexity, it allows us to obtain diffraction-limited resolution in various samples in vivo. For the strongly scattering mouse brain, a single aberration correction improves structural and functional imaging of fine neuronal processes over a large imaging volume. PMID:25128976
Study of residual aberration for non-imaging focusing heliostat
Chen, Y.T.; Chong, K.K.; Lim, B.H.; Lim, C.S. [Institute of Energy and Environment, Malaysia University of Science and Technology, No. 17, Jalan SS7/26, Kelana Jaya, 47301 Petaling Jaya, Selangor (Malaysia)
2003-08-01
Instead of using a specific focusing geometry, a non-imaging focusing heliostat has no fixed geometry but is composed of many small movable element mirrors that can be manoeuvred to eliminate the first-order aberration. Following our previous publication on the principle of non-imaging focusing heliostat, this paper further explores higher order residual aberration that limits the size of the focusing spot. The residual aberration can be partially corrected by offsetting the pivot point of mirrors and pre-setting the tilting angles of mirrors.
He, Wenjun; Fu, Yuegang; Liu, Zhiying; Zhang, Lei; Wang, Jiake; Zheng, Yang; Li, Yahong
2017-03-01
The polarization aberrations of a complex optical system with multi-element lens have been investigated using a 3D polarization aberration function. The 3D polarization ray-tracing matrix has been combined with the optical path difference to obtain a 3D polarization aberration function, which avoids the need for a complicated phase unwrapping process. The polarization aberrations of a microscope objective have been analyzed to include, the distributions of 3D polarization aberration functions, diattenuation aberration, retardance aberration, and polarization-dependent intensity on the exit pupil. Further, the aberrations created by the field of view and the coating on the distribution rules of 3D polarization aberration functions are discussed in detail. Finally a novel appropriate field of view and wavelength correction is proposed for a polarization aberration function which optimizes the image quality of a multi-element optical system.
Feng, Kaiqiang; Li, Jie; Zhang, Xiaoming; Shen, Chong; Bi, Yu; Zheng, Tao; Liu, Jun
2017-09-19
In order to reduce the computational complexity, and improve the pitch/roll estimation accuracy of the low-cost attitude heading reference system (AHRS) under conditions of magnetic-distortion, a novel linear Kalman filter, suitable for nonlinear attitude estimation, is proposed in this paper. The new algorithm is the combination of two-step geometrically-intuitive correction (TGIC) and the Kalman filter. In the proposed algorithm, the sequential two-step geometrically-intuitive correction scheme is used to make the current estimation of pitch/roll immune to magnetic distortion. Meanwhile, the TGIC produces a computed quaternion input for the Kalman filter, which avoids the linearization error of measurement equations and reduces the computational complexity. Several experiments have been carried out to validate the performance of the filter design. The results demonstrate that the mean time consumption and the root mean square error (RMSE) of pitch/roll estimation under magnetic disturbances are reduced by 45.9% and 33.8%, respectively, when compared with a standard filter. In addition, the proposed filter is applicable for attitude estimation under various dynamic conditions.
相似物体的姿态矫正算法设计及实现%DESIGN AND IMPLEMENTATION OF ATTITUDE CORRECTION ALGORITHM FOR SIMILAR OBJECTS
刘喜平; 赵强; 郭希娟
2013-01-01
When comparing the features of points in 3-dimensional point cloud recognition process, spatial attitude transform must be taken into account due to different attitudes of point cloud, but the old algorithm of spatial attitude is of high complexity and of high computation cost. To deal with the above issues, we propose an attitude correction algorithm for similar objects. It chooses three groups of non-collinear corresponding points at the position the two similar objects are to be identified, through space transformation and rotation it unifies the attitudes of similar parts to set up the base for objects recognition. The feasibility and validity of the algorithm are proved by the correction using point cloud model of the car.%在三维点云识别过程中,由于点云姿态不同,比较点的特征时,要将空间姿态变换计算在内,旧的空间姿态算法复杂度高,计算量大.针对上述问题,提出一种相似物体的姿态矫正算法,通过在两个相似物体要进行识别的位置上选择不共线的三组对应点,经过空间变换与旋转,将相似部位的姿态统一,为物体识别做基础.通过使用汽车点云模型进行矫正,验证了该算法的可行性和正确性.
Design of image correction algorithm based on Catapult C Synthesis%基于 Catapult C Synthesis 的图像校正算法设计
李杨
2016-01-01
The jitter of remote sensor during exercise will cause the image position shift .To settle this problem ,a real‐time image correction algorithm is proposed .However ,the design of algorithm by using HDL has great difficulty and it leads to long development cycle .Therefore ,the design of algorithm is achieved by adopting C language .Then the abstract C algorithm is translated to RLT code by means of Calypto’s Catapult C Synthesis tools .Furthermore ,a co‐simulation test of C/C+ + and RLT is carried out in Catapult C Synthesis tools .It’s also verified in the platform of XC5VLX110T .The results of Simulation test and hardware verification show that the algorithm designed by applying Catapult C Synthesis tools can meet the design requirements both in timing and performance .And it can correct the shifted image in real‐time .%为解决遥感相机在运动过程中的抖动造成的图像位置偏移问题，提出了一种实时图像校正算法。由于在FPGA中采用HDL进行算法设计难度大、开发周期长，故设计中采用了C语言进行算法设计，然后借助Calypto公司的Catapult C Synthesis工具将抽象的C设计转换成硬件RTL代码。在Catapult C Synthesis中对设计的算法进行了C／C＋＋、RLT协同仿真测试，并在Xilinx XC5VLX110T型FPGA上进行了验证。仿真测试及硬件验证结果表明，采用Catapult C Synthesis设计的算法在时序、性能方面均满足设计要求，能够对偏移的图像进行实时校正。
Scarino, Benjamin R.; Minnis, Patrick; Chee, Thad; Bedka, Kristopher M.; Yost, Christopher R.; Palikonda, Rabindra
2017-01-01
Surface skin temperature (Ts) is an important parameter for characterizing the energy exchange at the ground/water-atmosphere interface. The Satellite ClOud and Radiation Property retrieval System (SatCORPS) employs a single-channel thermal-infrared (TIR) method to retrieve Ts over clear-sky land and ocean surfaces from data taken by geostationary Earth orbit (GEO) and low Earth orbit (LEO) satellite imagers. GEO satellites can provide somewhat continuous estimates of Ts over the diurnal cycle in non-polar regions, while polar Ts retrievals from LEO imagers, such as the Advanced Very High Resolution Radiometer (AVHRR), can complement the GEO measurements. The combined global coverage of remotely sensed Ts, along with accompanying cloud and surface radiation parameters, produced in near-realtime and from historical satellite data, should be beneficial for both weather and climate applications. For example, near-realtime hourly Ts observations can be assimilated in high-temporal-resolution numerical weather prediction models and historical observations can be used for validation or assimilation of climate models. Key drawbacks to the utility of TIR-derived Ts data include the limitation to clear-sky conditions, the reliance on a particular set of analyses/reanalyses necessary for atmospheric corrections, and the dependence on viewing and illumination angles. Therefore, Ts validation with established references is essential, as is proper evaluation of Ts sensitivity to atmospheric correction source.This article presents improvements on the NASA Langley GEO satellite and AVHRR TIR-based Ts product that is derived using a single-channel technique. The resulting clear-sky skin temperature values are validated with surface references and independent satellite products. Furthermore, an empirically adjusted theoretical model of satellite land surface temperature (LST) angular anisotropy is tested to improve satellite LST retrievals. Application of the anisotropic correction
Scarino, Benjamin R.; Minnis, Patrick; Chee, Thad; Bedka, Kristopher M.; Yost, Christopher R.; Palikonda, Rabindra
2017-01-01
Surface skin temperature (T(sub s)) is an important parameter for characterizing the energy exchange at the ground/water-atmosphere interface. The Satellite ClOud and Radiation Property retrieval System (SatCORPS) employs a single-channel thermal-infrared (TIR) method to retrieve T(sub s) over clear-sky land and ocean surfaces from data taken by geostationary Earth orbit (GEO) and low Earth orbit (LEO) satellite imagers. GEO satellites can provide somewhat continuous estimates of T(sub s) over the diurnal cycle in non-polar regions, while polar T(sub s) retrievals from LEO imagers, such as the Advanced Very High Resolution Radiometer (AVHRR), can complement the GEO measurements. The combined global coverage of remotely sensed T(sub s), along with accompanying cloud and surface radiation parameters, produced in near-realtime and from historical satellite data, should be beneficial for both weather and climate applications. For example, near-realtime hourly T(sub s) observations can be assimilated in high-temporal-resolution numerical weather prediction models and historical observations can be used for validation or assimilation of climate models. Key drawbacks to the utility of TIR-derived T(sub s) data include the limitation to clear-sky conditions, the reliance on a particular set of analyses/reanalyses necessary for atmospheric corrections, and the dependence on viewing and illumination angles. Therefore, T(sub s) validation with established references is essential, as is proper evaluation of T(sub s) sensitivity to atmospheric correction source. This article presents improvements on the NASA Langley GEO satellite and AVHRR TIR-based T(sub s) product that is derived using a single-channel technique. The resulting clear-sky skin temperature values are validated with surface references and independent satellite products. Furthermore, an empirically adjusted theoretical model of satellite land surface temperature (LST) angular anisotropy is tested to improve
低仰角对流层折射修正快速算法%A Fast and Efficient Algorithm of Tropospheric Refraction Correction at Low Elevation
段成林; 马传令; 曹建峰
2011-01-01
大气的折射效应引起电波传播延迟和路径弯曲,测量数据对流层修正的精度直接影响到飞行目标轨(弹)道确定的精度.考虑到对流层折射修正的精度和效率以及5.以下低仰角数据传统修正方法具有较大的误差,通常不对测量数据进行实时对流层折射修正,这使得实时定位的精度受到较大影响.研究设计了一种能够应用于实时数据处理快速有效的对流层折射修正迭代算法.经大量外场实测数据验证,该算法能够有效地消除低仰角对流层折射偏差,对高仰角测量数据的对流层折射修正亦具有较高的精度.%Since the effect of atmospheric refraction leads to radiowave propagation delay and path bending, the accuracy of tropospheric radiowave refractive error correction of the detected data directly influences orbit determination accuracy of flighting targets. In consideration of low precision or low efficiency of the tropospheric refraction correction, especially the big error of traditional correction methods for correcting the data of low elevation below 5?, the real-time tropospheric refraction correction for the detected data isn't often adopted. It brings great impact to the accuracy of real-time orbit determination. A new fast and efficient iterative algorithm for tropospheric refraction correction is designed and studied, which can be applied to real-time data processing. Experimental results based on mass quantities of measured data in outfield verify the validity and effectiveness of this method in eliminating tropospheric refractive error at low elevation. Meanwhile, a better correction precision can be obtained at high elevation.
McGuire, Patrick C; Brown, Adrian J; Fraeman, Abigail A; Marzo, Giuseppe A; Morgan, M Frank; Murchie, Scott L; Mustard, John F; Parente, Mario; Pelkey, Shannon M; Roush, Ted L; Seelos, Frank P; Smith, Michael D; Wendt, Lorenz; Wolff, Michael J
2009-01-01
The observations of Mars by the CRISM and OMEGA hyperspectral imaging spectrometers require correction for photometric, atmospheric and thermal effects prior to the interpretation of possible mineralogical features in the spectra. Here, we report on a simple, yet non-trivial, adaptation to the commonly-used volcano-scan correction technique for atmospheric CO_2, which allows for the improved detection of minerals with intrinsic absorption bands at wavelengths between 1.9-2.1 $\\mu$m. This volcano-scan technique removes the absorption bands of CO_2 by ensuring that the Lambert albedo is the same at two wavelengths: 1.890 $\\mu$m and 2.011 $\\mu$m, with the first wavelength outside the CO_2 gas bands and the second wavelength deep inside the CO_2 gas bands. Our adaptation to the volcano-scan technique moves the first wavelength from 1.890 $\\mu$m to be instead within the gas bands at 1.980 $\\mu$m, and for CRISM data, our adaptation shifts the second wavelength slightly, to 2.007 $\\mu$m. We also report on our effort...
Polarization Aberrations of Optical Coatings
Jota, Thiago
This work does not limit itself to its title and touches on a number of related topics beyond it. Starting with the title, Polarization Aberrations of Optical Coatings, the immediate question that comes to mind is: what coatings? All coatings? Not all coatings, but just enough that a third person could take this information and apply it anywhere: to all coatings. The computational work-flow required to break-down the aberrations caused by polarizing events (3D vector forms of reflection and refraction) in dielectric and absorbing materials and for thick and thin films is presented. Therefore, it is completely general and of interest to the wide optics community. The example system is a Ritchey-Chretien telescope. It looks very similar to a Cassegrain, but it is not. It has hyperbolic surfaces, which allows for more optical aberration corrections. A few modern systems that use this configuration are the Hubble Space Telescope and the Keck telescopes. This particular system is a follow-up on this publication, where an example Cassegrain with aluminum coatings is characterized, and I was asked to simply evaluate it at another wavelength. To my surprise, I found a number of issues which lead me to write a completely new, one-of-its-kind 3D polarization ray-tracing code. It can do purely geometrical ray-tracing with add-on the polarization analysis capability, and more importantly: it keeps your data at your fingertips while offering all the outstanding facilities of Mathematica. The ray-tracing code and its extensive library, which can do several advanced computations, is documented in the appendix. The coatings of the Ritchey-Chretien induce a number of aberrations, primarily, but not limited to: tilt, defocus, astigmatism, and coma. I found those forms to exist in both aluminum and with a reflectance-enhancing dielectric quarter-wave multilayer coating over aluminum. The thickness of the film stack varies as function of position to present a quarter-wave of optical
Limbacher, James A.; Kahn, Ralph A.
2017-01-01
As aerosol amount and type are key factors in the 'atmospheric correction' required for remote-sensing chlorophyll alpha concentration (Chl) retrievals, the Multi-angle Imaging SpectroRadiometer (MISR) can contribute to ocean color analysis despite a lack of spectral channels optimized for this application. Conversely, an improved ocean surface constraint should also improve MISR aerosol-type products, especially spectral single-scattering albedo (SSA) retrievals. We introduce a coupled, self-consistent retrieval of Chl together with aerosol over dark water. There are time-varying MISR radiometric calibration errors that significantly affect key spectral reflectance ratios used in the retrievals. Therefore, we also develop and apply new calibration corrections to the MISR top-of-atmosphere (TOA) reflectance data, based on comparisons with coincident MODIS (Moderate Resolution Imaging Spectroradiometer) observations and trend analysis of the MISR TOA bidirectional reflectance factors (BRFs) over three pseudo-invariant desert sites. We run the MISR research retrieval algorithm (RA) with the corrected MISR reflectances to generate MISR-retrieved Chl and compare the MISR Chl values to a set of 49 coincident SeaBASS (SeaWiFS Bio-optical Archive and Storage System) in situ observations. Where Chl(sub in situ) less than 1.5 mg m(exp -3), the results from our Chl model are expected to be of highest quality, due to algorithmic assumption validity. Comparing MISR RA Chl to the 49 coincident SeaBASS observations, we report a correlation coefficient (r) of 0.86, a root-mean-square error (RMSE) of 0.25, and a median absolute error (MAE) of 0.10. Statistically, a two-sample Kolmogorov- Smirnov test indicates that it is not possible to distinguish between MISR Chl and available SeaBASS in situ Chl values (p greater than 0.1). We also compare MODIS-Terra and MISR RA Chl statistically, over much broader regions. With about 1.5 million MISR-MODIS collocations having MODIS Chl less
Zhang, J; Zhang, W; Lu, J [Cancer Hospital of Shantou University Medical College, Shantou, Guangdong (China)
2015-06-15
Purpose: To investigate the accuracy and feasibility of dose calculations using kilovoltage cone beam computed tomography in cervical cancer radiotherapy using a correction algorithm. Methods: The Hounsfield units (HU) and electron density (HU-density) curve was obtained for both planning CT (pCT) and kilovoltage cone beam CT (CBCT) using a CIRS-062 calibration phantom. The pCT and kV-CBCT images have different HU values, and if the HU-density curve of CBCT was directly used to calculate dose in CBCT images may have a deviation on dose distribution. It is necessary to normalize the different HU values between pCT and CBCT. A HU correction algorithm was used for CBCT images (cCBCT). Fifteen intensity-modulated radiation therapy (IMRT) plans of cervical cancer were chosen, and the plans were transferred to the pCT and cCBCT data sets without any changes for dose calculations. Phantom and patient studies were carried out. The dose differences and dose distributions were compared between cCBCT plan and pCT plan. Results: The HU number of CBCT was measured by several times, and the maximum change was less than 2%. To compare with pCT, the CBCT and cCBCT has a discrepancy, the dose differences in CBCT and cCBCT images were 2.48%±0.65% (range: 1.3%∼3.8%) and 0.48%±0.21% (range: 0.1%∼0.82%) for phantom study, respectively. For dose calculation in patient images, the dose differences were 2.25%±0.43% (range: 1.4%∼3.4%) and 0.63%±0.35% (range: 0.13%∼0.97%), respectively. And for the dose distributions, the passing rate of cCBCT was higher than the CBCTs. Conclusion: The CBCT image for dose calculation is feasible in cervical cancer radiotherapy, and the correction algorithm offers acceptable accuracy. It will become a useful tool for adaptive radiation therapy.
Li, Liang; Ran, Xu; Wu, Kaihui; Song, Jian; Han, Zongqi
2015-06-01
The traction control system (TCS) might prevent excessive skid of the driving wheels so as to enhance the driving performance and direction stability of the vehicle. But if driven on an uneven low-friction road, the vehicle body often vibrates severely due to the drastic fluctuations of driving wheels, and then the vehicle comfort might be reduced greatly. The vibrations could be hardly removed with traditional drive-slip control logic of the TCS. In this paper, a novel fuzzy logic controller has been brought forward, in which the vibration signals of the driving wheels are adopted as new controlled variables, and then the engine torque and the active brake pressure might be coordinately re-adjusted besides the basic logic of a traditional TCS. In the proposed controller, an adjustable engine torque and pressure compensation loop are adopted to constrain the drastic vehicle vibration. Thus, the wheel driving slips and the vibration degrees might be adjusted synchronously and effectively. The simulation results and the real vehicle tests validated that the proposed algorithm is effective and adaptable for a complicated uneven low-friction road.
On aberration in gravitational lensing
Sereno, M
2008-01-01
It is known that a relative translational motion between the deflector and the observer affects gravitational lensing. In this paper, a lens equation is obtained to describe such effects on actual lensing observables. Results can be easily interpreted in terms of aberration of light-rays. Both radial and transverse motions with relativistic velocities are considered. The lens equation is derived by first considering geodesic motion of photons in the rest-frame Schwarzschild spacetime of the lens, and, then, light-ray detection in the moving observer's frame. Due to the transverse motion images are displaced and distorted in the observer's celestial sphere, whereas the radial velocity along the line of sight causes an effective re-scaling of the lens mass. The Einstein ring is distorted to an ellipse whereas the caustics in the source plane are still point-like. Either for null transverse motion or up to linear order in velocities, the critical curve is still a circle with its radius corrected by a factor (1+z...
Morshed, Mohammad Sarwar; Kamal, Mostafa Mashnoon; Khan, Somaiya Islam
2016-07-01
Inventory has been a major concern in supply chain and numerous researches have been done lately on inventory control which brought forth a number of methods that efficiently manage inventory and related overheads by reducing cost of replenishment. This research is aimed towards providing a better replenishment policy in case of multi-product, single supplier situations for chemical raw materials of textile industries in Bangladesh. It is assumed that industries currently pursue individual replenishment system. The purpose is to find out the optimum ideal cycle time and individual replenishment cycle time of each product for replenishment that will cause lowest annual holding and ordering cost, and also find the optimum ordering quantity. In this paper indirect grouping strategy has been used. It is suggested that indirect grouping Strategy outperforms direct grouping strategy when major cost is high. An algorithm by Kaspi and Rosenblatt (1991) called RAND is exercised for its simplicity and ease of application. RAND provides an ideal cycle time (T) for replenishment and integer multiplier (ki) for individual items. Thus the replenishment cycle time for each product is found as T×ki. Firstly, based on data, a comparison between currently prevailing (individual) process and RAND is provided that uses the actual demands which presents 49% improvement in total cost of replenishment. Secondly, discrepancies in demand is corrected by using Holt's method. However, demands can only be forecasted one or two months into the future because of the demand pattern of the industry under consideration. Evidently, application of RAND with corrected demand display even greater improvement. The results of this study demonstrates that cost of replenishment can be significantly reduced by applying RAND algorithm and exponential smoothing models.
Evert van den Broek
2017-07-01
Full Text Available Development of cancer is driven by somatic alterations, including numerical and structural chromosomal aberrations. Currently, several computational methods are available and are widely applied to detect numerical copy number aberrations (CNAs of chromosomal segments in tumor genomes. However, there is lack of computational methods that systematically detect structural chromosomal aberrations by virtue of the genomic location of CNA-associated chromosomal breaks and identify genes that appear non-randomly affected by chromosomal breakpoints across (large series of tumor samples. ‘GeneBreak’ is developed to systematically identify genes recurrently affected by the genomic location of chromosomal CNA-associated breaks by a genome-wide approach, which can be applied to DNA copy number data obtained by array-Comparative Genomic Hybridization (CGH or by (low-pass whole genome sequencing (WGS. First, ‘GeneBreak’ collects the genomic locations of chromosomal CNA-associated breaks that were previously pinpointed by the segmentation algorithm that was applied to obtain CNA profiles. Next, a tailored annotation approach for breakpoint-to-gene mapping is implemented. Finally, dedicated cohort-based statistics is incorporated with correction for covariates that influence the probability to be a breakpoint gene. In addition, multiple testing correction is integrated to reveal recurrent breakpoint events. This easy-to-use algorithm, ‘GeneBreak’, is implemented in R (www.cran.r-project.org and is available from Bioconductor (www.bioconductor.org/packages/release/bioc/html/GeneBreak.html.
Cosmological parameter estimation: impact of CMB aberration
Catena, Riccardo
2012-01-01
The peculiar motion of an observer with respect to the CMB rest frame induces an apparent deflection of the observed CMB photons, i.e. aberration, and a shift in their frequency, i.e. Doppler effect. Both effects distort the temperature multipoles a_lm's via a mixing matrix at any l. The common lore when performing a CMB based cosmological parameter estimation is to consider that Doppler affects only the l=1 multipole, and neglect any other corrections. In this paper we reconsider the validity of this assumption, showing that it is actually not robust when sky cuts are included to model CMB foreground contaminations. Assuming a simple fiducial cosmological model with five parameters, we simulated CMB temperature maps of the sky in a WMAP-like and in a Planck-like experiment and added aberration and Doppler effects to the maps. We then analyzed with a MCMC in a Bayesian framework the maps with and without aberration and Doppler effects in order to assess the ability of reconstructing the parameters of the fidu...
Measuring chromatic aberrations in imaging systems using plasmonic nanoparticles
Gennaro, Sylvain D.; Roschuk, Tyler R.; Maier, Stefan A.; Oulton, Rupert F.
2016-04-01
Chromatic aberration in optical systems arises from the wavelength dependence of a glass's refractive index. Polychromatic rays incident upon an optical surface are refracted at slightly different angles and in traversing an optical system follow distinct paths creating images displaced according to color. Although arising from dispersion, it manifests as a spatial distortion correctable only with compound lenses with multiple glasses and accumulates in complicated imaging systems. While chromatic aberration is measured with interferometry, simple methods are attractive for their ease of use and low cost. In this letter we retrieve the longitudinal chromatic focal shift of high numerical aperture (NA) microscope objectives from the extinction spectra of metallic nanoparticles within the focal plane. The method is accurate for high NA objectives with apochromatic correction, and enables rapid assessment of the chromatic aberration of any complete microscopy systems, since it is straightforward to implement
Using Aberrant Behaviors as Reinforcers for Autistic Children.
Charlop, Marjorie H.; And Others
1990-01-01
Three experiments assessed the efficacy of various reinforcers to increase correct task responding in a total of 10 autistic children, aged 6-9. Of the reinforcers used (stereotypy, delayed echolalia, perseverative behavior, and food), task performance was highest with opportunities to engage in aberrant behaviors, and lowest with edible…
Stéfani Novoa
2017-01-01
Full Text Available The accurate measurement of suspended particulate matter (SPM concentrations in coastal waters is of crucial importance for ecosystem studies, sediment transport monitoring, and assessment of anthropogenic impacts in the coastal ocean. Ocean color remote sensing is an efficient tool to monitor SPM spatio-temporal variability in coastal waters. However, near-shore satellite images are complex to correct for atmospheric effects due to the proximity of land and to the high level of reflectance caused by high SPM concentrations in the visible and near-infrared spectral regions. The water reflectance signal (ρw tends to saturate at short visible wavelengths when the SPM concentration increases. Using a comprehensive dataset of high-resolution satellite imagery and in situ SPM and water reflectance data, this study presents (i an assessment of existing atmospheric correction (AC algorithms developed for turbid coastal waters; and (ii a switching method that automatically selects the most sensitive SPM vs. ρw relationship, to avoid saturation effects when computing the SPM concentration. The approach is applied to satellite data acquired by three medium-high spatial resolution sensors (Landsat-8/Operational Land Imager, National Polar-Orbiting Partnership/Visible Infrared Imaging Radiometer Suite and Aqua/Moderate Resolution Imaging Spectrometer to map the SPM concentration in some of the most turbid areas of the European coastal ocean, namely the Gironde and Loire estuaries as well as Bourgneuf Bay on the French Atlantic coast. For all three sensors, AC methods based on the use of short-wave infrared (SWIR spectral bands were tested, and the consistency of the retrieved water reflectance was examined along transects from low- to high-turbidity waters. For OLI data, we also compared a SWIR-based AC (ACOLITE with a method based on multi-temporal analyses of atmospheric constituents (MACCS. For the selected scenes, the ACOLITE-MACCS difference was
Spherical aberration from trajectories in real and hard-edge solenoid fields
BISWAS B
2016-06-01
For analytical, real and hard-edge solenoidal axial magnetic fields, the low-energy electron trajectories are obtained using the third-order paraxial ray equation. Using the particle trajectories, it is shown that the spherical aberration in the hard-edge model is high and it increases monotonously with hard edginess, although the focal length converges, in agreement with a recentfield and spherical aberration model. The model paved the way for a hard-edge approximation that gives correct focal length and spherical aberration, which is verified here by the trajectory method. In essence, we show that exact hard-edge fields give infinite spherical aberrations.
Theoretical estimates of spherical and chromatic aberration in photoemission electron microscopy.
Fitzgerald, J P S; Word, R C; Könenkamp, R
2016-01-01
We present theoretical estimates of the mean coefficients of spherical and chromatic aberration for low energy photoemission electron microscopy (PEEM). Using simple analytic models, we find that the aberration coefficients depend primarily on the difference between the photon energy and the photoemission threshold, as expected. However, the shape of the photoelectron spectral distribution impacts the coefficients by up to 30%. These estimates should allow more precise correction of aberration in PEEM in experimental situations where the aberration coefficients and precise electron energy distribution cannot be readily measured.
Zheng, C L; Etheridge, J
2013-02-01
A simple method is described for the accurate and precise measurement of chromatic aberration under electron-optical conditions pertinent to scanning transmission electron microscopy (STEM) and scanning confocal electron microscopy (SCEM). The method requires only the measurement of distances in a coherent CBED pattern and knowledge of the electron wavelength and the lattice spacing of a calibration specimen. The chromatic aberration of a spherical-aberration corrected 300 kV thermal field emission TEM is measured in STEM and SCEM operating modes and under different condenser lens settings. The effect of the measured chromatic aberrations on the 3 dimensional intensity distribution of the electron probe is also considered.
Study of the wavefront aberrations in children with amblyopia
ZHAO Peng-fei; ZHOU Yue-hua; WANG Ning-li; ZHANG Jing
2010-01-01
Background Amblyopia is a common ophthalmological condition and the wavefront aberrometer is a relatively new diagnostic tool used globally to measure optical characteristics of human eyes as well as to study refractive errors in amblyopic eyes. We studied the wavefront aberration of the amblyopic children's eyes and analyzed the mechanism of the wavefront aberration in the formation of the amblyopia, try to investigate the new evidence of the treatment of the amblyopia, especially in the refractory amblyopia.Methods The WaveScan Wavefront System (VISX, USA) aberrometer was used to investigate four groups of children under dark accommodation and cilliary muscle paralysis. There were 45 cases in the metropic group, 87 in the amblyopic group, 92 in the corrected-amblyopic group and 38 in the refractory amblyopic group. One-way analysis of variance (ANOVA), t-test and multivariate linear regression were used to analyze all the data.Results Third order to 6th order aberrations showed a decreasing trend whereas in the higher order aberrations the main ones were 3rd order coma (Z3-1-Z31), trefoil (Z3-3-Z33) and 4th order aberration (Z40); and 3rd order coma represented the highest percentage of all three main aberrations. Within 3rd order coma, vertical coma (Z3-1) accounted for a greater percentage than horizontal coma (Z31). Significant differences of vertical coma were found among all clinical groups of children: vertical coma in the amblyopic group (0.17±0.15) was significantly higher than in the metropic group (0.11±0.13, P0.05).Conclusions Although lower order aberrations such as defocus (myopia and hyperopia) and astigmatism are major factors determining the quality of the retinal image, higher order aberrations also need to be considered in amblyopic eyes as their effects are significant.
量子全加法器的修改和算法研究%Research on the algorithm of a corrected quantum full adder
郭良; 王利光; TERENCE K S W; TSUKADA M
2007-01-01
通过与经典全加器的基本模型进行比较后,讨论了一个改进后的量子平面加法器的基本构型.对其原理、组件和算法进行了研究,比较了本加法器两个主要组件与一般量子加法器的不同.作为应用的例,设计了一个n比特量子全加法器的模型,对其具体运算过程和基本功能进行了说明.%A corrected prototype of quantum plain adder after comparing with the classical counter part is presented. The authors discuss its basic principles, components and algorithm in this prototype, and also explain the difference between two main components used in the adder and those in the general quantum adder. For application, a construction model to perform n -qubit addition is built and its function is simply desoribed.
Superczynski, Stephen D.; Kondragunta, Shobha; Lyapustin, Alexei I.
2017-03-01
The multi-angle implementation of atmospheric correction (MAIAC) algorithm is under evaluation for use in conjunction with the Geostationary Coastal and Air Pollution Events mission. Column aerosol optical thickness (AOT) data from MAIAC are compared against corresponding data from the Visible Infrared Imaging Radiometer Suite (VIIRS) instrument over North America during 2013. Product coverage and retrieval strategy, along with regional variations in AOT through comparison of both matched and unmatched seasonally gridded data, are reviewed. MAIAC shows extended coverage over parts of the continent when compared to VIIRS, owing to its pixel selection process and ability to retrieve aerosol information over brighter surfaces. To estimate data accuracy, both products are compared with Aerosol Robotic Network level 2 measurements to determine the amount of error present and discover if there is any dependency on viewing geometry and/or surface characteristics. Results suggest that MAIAC performs well over this region with a relatively small bias of -0.01; however, there is a tendency for greater negative biases over bright surfaces and at larger scattering angles. Additional analysis over an expanded area and longer time period are likely needed to determine a comprehensive assessment of the products' capability over the Western Hemisphere.
Wavefront correction in a shaped-pupil coronagraph using a Gerchberg-Saxton-based estimation scheme
Kay, Jason; Kasdin, N. Jeremy; Belikov, Ruslan
2007-09-01
The detection of extra-solar terrestrial planets requires the use of space-based high-contrast imaging. Stellar photon noise as well as light thrown about by system aberrations necessitate the use of a high quality light suppression system and a method for wavefront correction. We present here a wavefront estimation scheme to be used with estimate-based correction for the shaped pupil coronagraph. In order to properly estimate the field in a reimaged pupil plane, we employ the use of the iterative Gerchberg-Saxton estimation algorithm between it and a second-focus image plane. We utilize the correction algorithm to overcome an ambiguity inherent in Gerchberg-Saxton estimation.
Phase aberration effects in elastography.
Varghese, T; Bilgen, M; Ophir, J
2001-06-01
In sonography, phase aberration plays a role in the corruption of sonograms. Phase aberration does not have a significant impact on elastography, if statistically similar phase errors are present in both the pre- and postcompression signals. However, if the phase errors are present in only one of the pre- or postcompression signal pairs, the precision of the strain estimation process will be reduced. In some cases, increased phase errors may occur only in the postcompression signal due to changes in the tissue structure with the applied compression. Phase-aberration effects increase with applied strain and may be viewed as an image quality derating factor, much like frequency-dependent attenuation or undesired lateral tissue motion. In this paper, we present a theoretical and simulation study of the effects of phase aberration on the elastographic strain-estimation process, using the strain filter approach.
DNA Repair Defects and Chromosomal Aberrations
Hada, Megumi; George, K. A.; Huff, J. L.; Pluth, J. M.; Cucinotta, F. A.
2009-01-01
Yields of chromosome aberrations were assessed in cells deficient in DNA doublestrand break (DSB) repair, after exposure to acute or to low-dose-rate (0.018 Gy/hr) gamma rays or acute high LET iron nuclei. We studied several cell lines including fibroblasts deficient in ATM (ataxia telangiectasia mutated; product of the gene that is mutated in ataxia telangiectasia patients) or NBS (nibrin; product of the gene mutated in the Nijmegen breakage syndrome), and gliomablastoma cells that are proficient or lacking in DNA-dependent protein kinase (DNA-PK) activity. Chromosomes were analyzed using the fluorescence in situ hybridization (FISH) chromosome painting method in cells at the first division post irradiation, and chromosome aberrations were identified as either simple exchanges (translocations and dicentrics) or complex exchanges (involving >2 breaks in 2 or more chromosomes). Gamma irradiation induced greater yields of both simple and complex exchanges in the DSB repair-defective cells than in the normal cells. The quadratic dose-response terms for both simple and complex chromosome exchanges were significantly higher for the ATM- and NBS-deficient lines than for normal fibroblasts. However, in the NBS cells the linear dose-response term was significantly higher only for simple exchanges. The large increases in the quadratic dose-response terms in these repair-defective cell lines points the importance of the functions of ATM and NBS in chromatin modifications to facilitate correct DSB repair and minimize the formation of aberrations. The differences found between ATM- and NBS-deficient cells at low doses suggest that important questions should with regard to applying observations of radiation sensitivity at high dose to low-dose exposures. For aberrations induced by iron nuclei, regression models preferred purely linear dose responses for simple exchanges and quadratic dose responses for complex exchanges. Relative biological effectiveness (RBE) factors of all of
DNA Repair Defects and Chromosomal Aberrations
Hada, Megumi; George, K. A.; Huff, J. L.; Pluth, J. M.; Cucinotta, F. A.
2009-01-01
Yields of chromosome aberrations were assessed in cells deficient in DNA doublestrand break (DSB) repair, after exposure to acute or to low-dose-rate (0.018 Gy/hr) gamma rays or acute high LET iron nuclei. We studied several cell lines including fibroblasts deficient in ATM (ataxia telangiectasia mutated; product of the gene that is mutated in ataxia telangiectasia patients) or NBS (nibrin; product of the gene mutated in the Nijmegen breakage syndrome), and gliomablastoma cells that are proficient or lacking in DNA-dependent protein kinase (DNA-PK) activity. Chromosomes were analyzed using the fluorescence in situ hybridization (FISH) chromosome painting method in cells at the first division post irradiation, and chromosome aberrations were identified as either simple exchanges (translocations and dicentrics) or complex exchanges (involving >2 breaks in 2 or more chromosomes). Gamma irradiation induced greater yields of both simple and complex exchanges in the DSB repair-defective cells than in the normal cells. The quadratic dose-response terms for both simple and complex chromosome exchanges were significantly higher for the ATM- and NBS-deficient lines than for normal fibroblasts. However, in the NBS cells the linear dose-response term was significantly higher only for simple exchanges. The large increases in the quadratic dose-response terms in these repair-defective cell lines points the importance of the functions of ATM and NBS in chromatin modifications to facilitate correct DSB repair and minimize the formation of aberrations. The differences found between ATM- and NBS-deficient cells at low doses suggest that important questions should with regard to applying observations of radiation sensitivity at high dose to low-dose exposures. For aberrations induced by iron nuclei, regression models preferred purely linear dose responses for simple exchanges and quadratic dose responses for complex exchanges. Relative biological effectiveness (RBE) factors of all of
Influence of spherical aberrations on fundamental mode beam quality under different laser resonators
Xiang Zhen; Hu Miao; Ge Jian-Hong; Zhao Zhi-Gang; Wang Sha; Liu Chong; Chen Jun
2009-01-01
Spherical aberrations of the thermal lens of the active media are severe when solid state lasers are strongly pumped.The fundamental mode profile deteriorates due to the aberrations. Self-consistent modes of a resonator with aberrations are calculated by using the Fox-Li diffraction iterative algorithm. Calculation results show that the aberration induced fundamental mode beam quality deterioration depends greatly on the resonator design. The tolerance of a flat-flat resonator to the aberration coefficient is about 30λ in the middle of stability, where λ is the wavelength of laser beam. But for a dynamically stable resonator, 2λ of spherical aberration will create diffraction loss of more than 40%, if inappropriate design criteria are used. A birefringence compensated laser resonator with two Nd:YAG rods is experimentally studied. The experimental data are in quite good agreement with simulation results.
Albino, Lucas D.; Santos, Gabriela R.; Ribeiro, Victor A.B.; Rodrigues, Laura N., E-mail: lucasdelbem1@gmail.com [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Faculdade de Medicina. Instituto de Radiologia; Weltman, Eduardo; Braga, Henrique F. [Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, SP (Brazil). Servico de Radioterapia
2013-12-15
The dose accuracy calculated by a treatment planning system is directly related to the chosen algorithm. Nowadays, several calculation doses algorithms are commercially available and they differ in calculation time and accuracy, especially when individual tissue densities are taken into account. The aim of this study was to compare two different calculation algorithms from iPlan®, BrainLAB, in the treatment of pituitary gland tumor with intensity-modulated radiation therapy (IMRT). These tumors are located in a region with variable electronic density tissues. The deviations from the plan with no heterogeneity correction were evaluated. To initial validation of the data inserted into the planning system, an IMRT plan was simulated in a anthropomorphic phantom and the dose distribution was measured with a radiochromic film. The gamma analysis was performed in the film, comparing it with dose distributions calculated with X-ray Voxel Monte Carlo (XVMC) algorithm and pencil beam convolution (PBC). Next, 33 patients plans, initially calculated by PBC algorithm, were recalculated with XVMC algorithm. The treatment volumes and organs-at-risk dose-volume histograms were compared. No relevant differences were found in dose-volume histograms between XVMC and PBC. However, differences were obtained when comparing each plan with the plan without heterogeneity correction. (author)
Bio-optical algorithms have been applied to monitor water quality in surface water systems. Empirical algorithms, such as Ritchie (2008), Gons (2008), and Gilerson (2010), have been applied to estimate the chlorophyll-a (chl-a) concentrations. However, the performance of each algorithm severely degr...
Environmental Transmission Electron Microscopy in an Aberration-Corrected Environment
Hansen, Thomas W.; Wagner, Jakob B.
2012-01-01
The increasing use of environmental transmission electron microscopy (ETEM) in materials science provides exciting new possibilities for investigating chemical reactions and understanding both the interaction of fast electrons with gas molecules and the effect of the presence of gas on high-resol...
Aberration corrected STEM to study an ancient hair dyeing formula
Patriarche, G.; Van Elslande, E.; Castaing, J.; Walter, P.
2014-05-01
Lead-based chemistry was initiated in ancient Egypt for cosmetic preparation more than 4000 years ago. Here, we study a hair-dyeing recipe using lead salts described in text since Greco-Roman times. We report direct evidence about the shape and distribution of PbS nanocrystals that form within the hair during blackening.
对网格中间区域矫正更优的图像矫正算法%The Optimized Image Correction Algorithm for the Middle Area of Grids
闵小平; 黄绍辉; 陈传本; 柏朋刚
2012-01-01
In conventional radiotherapy, the images obtained by the image intensifier of radiotherapy simulator are often distorted. In order to ensure the accuracy of radiotherapy, corrections must be conducted. Hence, an image correction algorithm is proposed with the objective function based on the distance of a point to a straight line. Given the correction speed, precision and smoothness, the moving least square method based on the primary linear base is adopted to correct images firstly and the results are satisfactory. Furthermore, on account of the characteristic that corrected grid lines should be straight, the number of reference points is increased so that the middle area of intersection points has reference points too. The corrected results present that after the correction, grid lines are more similar to straight line, and the correction effects of intersection areas are better than those of correction algorithm, which only take into account the intersection points. In addition, although more than 2 000 reference points are increased, the algorithm running time remains short.%常规放疗中模拟定位机影像增强器采集的图像常存在失真,为了保证放疗的精度,必须进行矫正,为此提出一种以点到直线距离为目标函数的图像矫正算法.在综合考虑矫正的速度、精度、平滑性的前提下,先采用基于一次线性基的移动最小二乘法对图像进行了矫正,取得了比较理想的结果；进一步,利用矫正后各线条应该为直线这一特征增加了参考点的数量,使交叉点中间区域也有了参考点.矫正结果显示,矫正之后各网格线呈现更理想的直线,交叉点之间的区域矫正比只考虑交叉点的矫正算法理想.当参考点增加到2 000多个点时,算法运行时间仍然较短.
Mohammad; Taher; Rajabi; Sara; Korouji; Mahgol; Farjadnia; Mohammad; Naderan; Mohammad; Bagher; Rajabi; Bahram; Khosravi; Seyed; Mehdi; Tabatabaie
2015-01-01
AIM: To compare higher order aberrations in two aspherical intraocular lenses(IOLs): Akreos advanced optics(AO) and Dr. Schmidt Microcrystalline 6125 aspheric anterior surface(MC6125AS) with each other. METHODS: Forty eyes of 39 patients underwent phacoemulsification and Akreos AO and MC6125 AS were implanted in their eyes in a random manner. Three months post-operatively, higher order aberrations including spherical aberration, coma aberration, and total aberrations were measured and compared.RESULTS: The total aberration was 0.24±0.17 in eyes with Dr. Schmidt and 0.20 ±0.01 in eyes with Akreos AO(P =0.361). The mean of coma aberration was 0.17 ±0.21 and 0.09 ±0.86 in Dr. Schmidt and Akreos lenses,respectively(P =0.825). Total spherical aberration was almost the same in both groups(mean: 0.05, P =0.933).Best corrected visual acuity in Akreos AO(0.10±0.68) and Dr. Schmidt(0.09±0.67) did not differ significantly(P =0.700). CONCLUSION: There is no statistically significant difference in the higher order aberrations between these two aspherical lenses.
Scarino, B. R.; Minnis, P.; Yost, C. R.; Chee, T.; Palikonda, R.
2015-12-01
Single-channel algorithms for satellite thermal-infrared- (TIR-) derived land and sea surface skin temperature (LST and SST) are advantageous in that they can be easily applied to a variety of satellite sensors. They can also accommodate decade-spanning instrument series, particularly for periods when split-window capabilities are not available. However, the benefit of one unified retrieval methodology for all sensors comes at the cost of critical sensitivity to surface emissivity (ɛs) and atmospheric transmittance estimation. It has been demonstrated that as little as 0.01 variance in ɛs can amount to more than a 0.5-K adjustment in retrieved LST values. Atmospheric transmittance requires calculations that employ vertical profiles of temperature and humidity from numerical weather prediction (NWP) models. Selection of a given NWP model can significantly affect LST and SST agreement relative to their respective validation sources. Thus, it is necessary to understand the accuracies of the retrievals for various NWP models to ensure the best LST/SST retrievals. The sensitivities of the single-channel retrievals to surface emittance and NWP profiles are investigated using NASA Langley historic land and ocean clear-sky skin temperature (Ts) values derived from high-resolution 11-μm TIR brightness temperature measured from geostationary satellites (GEOSat) and Advanced Very High Resolution Radiometers (AVHRR). It is shown that mean GEOSat-derived, anisotropy-corrected LST can vary by up to ±0.8 K depending on whether CERES or MODIS ɛs sources are used. Furthermore, the use of either NOAA Global Forecast System (GFS) or NASA Goddard Modern-Era Retrospective Analysis for Research and Applications (MERRA) for the radiative transfer model initial atmospheric state can account for more than 0.5-K variation in mean Ts. The results are compared to measurements from the Surface Radiation Budget Network (SURFRAD), an Atmospheric Radiation Measurement (ARM) Program ground
Aberration of Light and Motion of Real Particle
Klacka, J
2000-01-01
Correct and complete (to terms of $\\vec{v} / c$ -- $\\vec{v}$ is particle's velocity, $c$ is the speed of light) derivation of equation of motion for real dust particle under the action of electromagnetic radiation is derived. The effect of aberration of light is used. Equation of motion is expressed in terms of particle's optical properties, standardly used in optics for stationary particles.
Fairbanks, L.R.; Barbi, G.L.; Silva, W.T. da; Reis, E.G.F. dos; Borges, L.F.; Bertucci, E.C.; Maciel, M.F.; Amaral, L.L. do, E-mail: lefairbanks@yahoo.com.b [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Hospital das Clinicas. Servico de Radioterapia
2010-07-01
Since the cross-section for various radiation interactions is dependent upon tissue material, the presence of heterogeneities affects the final dose delivered. This paper aims to analyze how different treatment planning algorithms (Fast Fourier Transform, Convolution, Superposition, Fast Superposition and Clarkson) work when heterogeneity corrections are used. To that end, a farmer-type ionization chamber was positioned reproducibly (during the time of CT as well as irradiation) inside several phantoms made of aluminum, bone, cork and solid water slabs. The percent difference between the dose measured and calculated by the various algorithms was less than 5%; This is in accordance with the recommendation of several references.The convolution method shows better results for high density materials (difference {approx}1 %), whereas the Superposition algorithm is more accurate for low densities (around 1,1%).
Fairbanks, Leandro R.; Barbi, Gustavo L.; Silva, Wiliam T.; Reis, Eduardo G.F.; Borges, Leandro F.; Bertucci, Edenyse C.; Maciel, Marina F.; Amaral, Leonardo L., E-mail: lefairbanks@yahoo.com.b [Universidade de Sao Paulo (HCRP/USP), Ribeirao Preto, SP (Brazil). Hospital das Clinicas. Servico de Radioterapia
2011-07-01
Since the cross-section for various radiation interactions is dependent upon tissue material, the presence of heterogeneities affects the final dose delivered. This paper aims to analyze how different treatment planning algorithms (Fast Fourier Transform, Convolution, Superposition, Fast Superposition and Clarkson) work when heterogeneity corrections are used. To that end, a farmer-type ionization chamber was positioned reproducibly (during the time of CT as well as irradiation) inside several phantoms made of aluminum, bone, cork and solid water slabs. The percent difference between the dose measured and calculated by the various algorithms was less than 5%.The convolution method shows better results for high density materials (difference {approx}1 %), whereas the Superposition algorithm is more accurate for low densities (around 1,1%). (author)
Ning, Yu; Sun, Quan; Wang, Hongyan; Wu, Wuming; Du, Shaojun; Xu, Xiaojun
2015-05-01
In a high-power laser system, a beam splitter refers to the mirror which locates at the cross point of the path of highpower beam and the weak light section. Because of the thermo-optic effect and elasto-optic effect, a beam splitter deforms under intense laser radiation. This deformation adds extra phase on the incident waves and deliveries inaccurate information to the wavefront sensor. Consequently, the output laser focuses at finite distance and gets divergent when arrives at the target. To settle the above problem, this paper presents a new method for real-time correction of the thermal distortion of beam splitter, based on algorithm of the data fusion of two Shack-Hartmann wavefront sensors (SH-WFS). Different from the traditional AO system, which contains a wavefront sensor, a corrector and a servo controller, two extra Shack-Hartmann wavefront detectors are adopted in our AO system, to detect the transmitted and reflected aberrations of beam splitter mirror. And these aberrations are real-timely delivered to the wavefront sensor. Based on coordinate conversion and data fusion algorithm, it makes the wavefront sensor of AO can "see" the aberrations of splitter mirror by itself. Thus, the servo system controls the corrector to compensate these aberrations correctly. In this paper, the theoretical model of data fusion algorithm is carried out. A closed-loop AO system, which consists of a typical AO system and two extra Shack-Hartmann wavefront detectors, is set up to validate the data fusion algorithm. Experimental results show that, the distortion of a CaF2 beam splitter can be real-time corrected when the AO closedloop control is on. The beam quality factor of output laser decreases from 4 to 1.7 times of diffraction limit.
Experimental repetitive quantum error correction.
Schindler, Philipp; Barreiro, Julio T; Monz, Thomas; Nebendahl, Volckmar; Nigg, Daniel; Chwalla, Michael; Hennrich, Markus; Blatt, Rainer
2011-05-27
The computational potential of a quantum processor can only be unleashed if errors during a quantum computation can be controlled and corrected for. Quantum error correction works if imperfections of quantum gate operations and measurements are below a certain threshold and corrections can be applied repeatedly. We implement multiple quantum error correction cycles for phase-flip errors on qubits encoded with trapped ions. Errors are corrected by a quantum-feedback algorithm using high-fidelity gate operations and a reset technique for the auxiliary qubits. Up to three consecutive correction cycles are realized, and the behavior of the algorithm for different noise environments is analyzed.
Effective spherical aberration of the cornea as a quantitative descriptor in corneal topography.
Seiler, T; Reckmann, W; Maloney, R K
1993-01-01
Following excimer laser photorefractive keratectomy and other refractive surgical procedures, complaints of halos, glare, and monocular diplopia are common. These procedures increase the asphericity of the cornea, which may cause the optical distortions. We used ray tracing techniques to estimate the longitudinal monochromatic aberration of the cornea from the measured corneal topography (effective spherical aberration) in 15 normal eyes with varying degrees of astigmatism and in ten eyes after photorefractive keratectomy. Best spherical corrected visual acuity in the astigmatic eyes was highly correlated with effective spherical aberration (r = -0.9527, P < .001). In the eyes that had photorefractive keratectomy, the effective spherical aberration was highly correlated with measured glare visual acuity (r = 0.875, P < .002). These results suggest that effective spherical aberration is a valuable topographic measure that provides information about the optical performance of aspheric corneas.
The BHVI-EyeMapper: peripheral refraction and aberration profiles.
Fedtke, Cathleen; Ehrmann, Klaus; Falk, Darrin; Bakaraju, Ravi C; Holden, Brien A
2014-10-01
The aim of this article was to present the optical design of a new instrument (BHVI-EyeMapper, EM), which is dedicated to rapid peripheral wavefront measurements across the visual field for distance and near, and to compare the peripheral refraction and higher-order aberration profiles obtained in myopic eyes with and without accommodation. Central and peripheral refractive errors (M, J180, and J45) and higher-order aberrations (C[3, 1], C[3, 3], and C[4, 0]) were measured in 26 myopic participants (mean [±SD] age, 20.9 [±2.0] years; mean [±SD] spherical equivalent, -3.00 [±0.90] diopters [D]) corrected for distance. Measurements were performed along the horizontal visual field with (-2.00 to -5.00 D) and without (+1.00 D fogging) accommodation. Changes as a function of accommodation were compared using tilt and curvature coefficients of peripheral refraction and aberration profiles. As accommodation increased, the relative peripheral refraction profiles of M and J180 became significantly (p 0.05). The peripheral aberration profiles of C[3, 1], C[3, 3], and C[4, 0] became significantly (p refraction and higher-order aberration profiles occurred during accommodation in myopic eyes. With its extended measurement capabilities, that is, permitting rapid peripheral refraction and higher-order aberration measurements up to visual field angles of ±50 degrees for distance and near (up to -5.00 D), the EM is a new advanced instrument that may provide additional insights in the ongoing quest to understand and monitor myopia development.
朱承
2015-01-01
为了能够在真实硬件平台上进行实现，对原有的误差校正构造性神经网络算法进行了优化，并对优化后的误差修正算法进行了FPGA设计与实现。提出算法通过在自动生成一个合适的神经架构的同时对二个参数进行设置来提高算法性能。对这种算法实现的所有步骤进行了全面的描述并利用两种基准问题对结果进行了深入分析。结果显示，与标准的基于个人计算机( PC)的实现相比，提出的神经网络算法FPGA实现在计算速度方面有着明显的提高，由此证明了FPGA在误差校正算法神经计算任务中的实用性及适用性。%In order to achieve in real hardware platform,the original error correction constructive neural network al-gorithm is optimized,and the optimized error correction algorithm is implemented based on FPGA. The proposed al-gorithm improves the performance of the algorithm by a set of two parameters in the automatic generation of a suit-able neural architecture. All steps of this algorithm give a comprehensive description and the use of two benchmark issues in-depth analysis of the results. The results show that compared with the implementation based on standard personal computer( PC) the proposed FPGA implementation of the neural network algorithm in this paper signifi-cantly improves the calculation speed,which proved the practicability and applicability of FPGA implementation in the error correction algorithm in neural computing task.
Using geometric algebra to study optical aberrations
Hanlon, J.; Ziock, H.
1997-05-01
This paper uses Geometric Algebra (GA) to study vector aberrations in optical systems with square and round pupils. GA is a new way to produce the classical optical aberration spot diagrams on the Gaussian image plane and surfaces near the Gaussian image plane. Spot diagrams of the third, fifth and seventh order aberrations for square and round pupils are developed to illustrate the theory.
李广亚; 王玉增; 韩婧茹; 刘双源
2014-01-01
Aimed at the linear distortion and nonlinear distortion appeared in laser galvanometer in mechanical parts in rapid pro-totyping,a laser galvanometer graphic correction algorithm was proposed. With using of this algorithm,on one hand,the distortion of linear laser galvanometer appeared in graphic scanning and in that of nonlinear could be eliminated,and on the other hand,compre-hensive error produced in laser galvanometer scanning process could be corrected. Experiments show that the algorithm eliminates the linear and nonlinear distortion generated,and corrects the integrated error produced,which provides satisfactory correction effect for the laser galvanometer in rapid prototyping manufacturing machinery accessories.%针对激光振镜在机械零件快速成型中出现的线性失真和非线性失真，提出了一种激光振镜的图形校正算法。利用该算法一方面可以消除激光振镜在图形扫描中出现的线性失真和非线性失真；另一方面可以校正激光振镜扫描过程中产生的综合误差。实验表明，通过该算法消除了产生的线性失真和非线性失真并且校正了产生的综合误差，为激光振镜在机械零件快速成型制造中提供了满意的校正效果。
Barrett, Todd K.; Sandler, David G.
1993-01-01
An artificial-neural-network method, first developed for the measurement and control of atmospheric phase distortion, using stellar images, was used to estimate the optical aberration of the Hubble Space Telescope. A total of 26 estimates of distortion was obtained from 23 stellar images acquired at several secondary-mirror axial positions. The results were expressed as coefficients of eight orthogonal Zernike polynomials: focus through third-order spherical. For all modes other than spherical the measured aberration was small. The average spherical aberration of the estimates was -0.299 micron rms, which is in good agreement with predictions obtained when iterative phase-retrieval algorithms were used.
Analysis of nodal aberration properties in off-axis freeform system design.
Shi, Haodong; Jiang, Huilin; Zhang, Xin; Wang, Chao; Liu, Tao
2016-08-20
Freeform surfaces have the advantage of balancing off-axis aberration. In this paper, based on the framework of nodal aberration theory (NAT) applied to the coaxial system, the third-order astigmatism and coma wave aberration expressions of an off-axis system with Zernike polynomial surfaces are derived. The relationship between the off-axis and surface shape acting on the nodal distributions is revealed. The nodal aberration properties of the off-axis freeform system are analyzed and validated by using full-field displays (FFDs). It has been demonstrated that adding Zernike terms, up to nine, to the off-axis system modifies the nodal locations, but the field dependence of the third-order aberration does not change. On this basis, an off-axis two-mirror freeform system with 500 mm effective focal length (EFL) and 300 mm entrance pupil diameter (EPD) working in long-wave infrared is designed. The field constant aberrations induced by surface tilting are corrected by selecting specific Zernike terms. The design results show that the nodes of third-order astigmatism and coma move back into the field of view (FOV). The modulation transfer function (MTF) curves are above 0.4 at 20 line pairs per millimeter (lp/mm) which meets the infrared reconnaissance requirement. This work provides essential insight and guidance for aberration correction in off-axis freeform system design.
Study on the design and Zernike aberrations of a segmented mirror telescope
Jiang Zhen-Yu; Li Lin; Huang Yi-Fan
2009-01-01
The segmented mirror telescope is widely used. The aberrations of segmented mirror systems are different from single mirror systems. This paper uses the Fourier optics theory to analyse the Zernike aberrations of segmented mirror systems. It concludes that the Zernike aberrations of segmented mirror systems obey the linearity theorem. The design of a segmented space telescope and segmented schemes are discussed, and its optical model is constructed. The computer simulation experiment is performed with this optical model to verify the suppositions. The experimental results confirm the correctness of the model.
Minato, A; Sugimoto, N
1998-01-20
A four-element retroreflector was designed for satellite laser ranging and Earth-satellite-Earth laser long-path absorption measurement of the atmosphere. The retroreflector consists of four symmetrically located corner retroreflectors. Each retroreflector element has curved mirrors and tuned dihedral angles to correct velocity aberrations. A genetic algorithm was employed to optimize dihedral angles of each element and the directions of the four elements. The optimized four-element retroreflector has high reflectance with a reasonably broad angular coverage. It is also shown that the genetic algorithm is effective for optimizing optics with many parameters.
Correlations between corneal and total wavefront aberrations
Mrochen, Michael; Jankov, Mirko; Bueeler, Michael; Seiler, Theo
2002-06-01
Purpose: Corneal topography data expressed as corneal aberrations are frequently used to report corneal laser surgery results. However, the optical image quality at the retina depends on all optical elements of the eye such as the human lens. Thus, the aim of this study was to investigate the correlations between the corneal and total wavefront aberrations and to discuss the importance of corneal aberrations for representing corneal laser surgery results. Methods: Thirty three eyes of 22 myopic subjects were measured with a corneal topography system and a Tschernig-type wavefront analyzer after the pupils were dilated to at least 6 mm in diameter. All measurements were centered with respect to the line of sight. Corneal and total wavefront aberrations were calculated up to the 6th Zernike order in the same reference plane. Results: Statistically significant correlations (p corneal and total wavefront aberrations were found for the astigmatism (C3,C5) and all 3rd Zernike order coefficients such as coma (C7,C8). No statistically significant correlations were found for all 4th to 6th order Zernike coefficients except for the 5th order horizontal coma C18 (p equals 0.003). On average, all Zernike coefficients for the corneal aberrations were found to be larger compared to Zernike coefficients for the total wavefront aberrations. Conclusions: Corneal aberrations are only of limited use for representing the optical quality of the human eye after corneal laser surgery. This is due to the lack of correlation between corneal and total wavefront aberrations in most of the higher order aberrations. Besides this, the data present in this study yield towards an aberration balancing between corneal aberrations and the optical elements within the eye that reduces the aberration from the cornea by a certain degree. Consequently, ideal customized ablations have to take both, corneal and total wavefront aberrations, into consideration.
钱玉文; 宋华菊; 赵邦信; 张彤芳; 郝劲松
2013-01-01
为解决传统检测方法检测隐蔽行为信道检测率较低的问题,提出了基于校正熵的隐蔽行为信道检测算法.所提算法利用向用户操作序列中嵌入隐蔽信息后,必然会引起其条件熵变化的原理进行检测.校正熵的引入,有效克服了利用条件熵进行检测会产生误报问题.基于校正熵对行为信道进行检测实验,检测结果表明,基于校正熵的隐蔽行为信道检测算法能够较好地在有噪声的环境中检测出几种常见的隐蔽时间信道,检测率约为96％.%To solve the problem that traditional covert channel detection algorithms cannot detect covert behavior channel precisely,a detection approach based on corrected entropy is proposed.The idea of detection approach is that when embedding the information into network operations of the users,the condition entropy of some features of network operations would be changed.In order to solve the problem of false alarm of the detector based on comdition entropy,the detection approach based on corrected entopy is proposed.Several experiments are done to detect several covert behavior channels to get the performance of the detection algorithm based on corrected entropy.The detection results show that the algorithm can work well in detecting several covert behavior channels and the detection rate is about 96％.
罗立强; 甘露; 吴晓军; 吉昂; 梁国立
2001-01-01
提出了神经网络基本参数-NNFP 算法。将 NNFP 算法应用于X射线荧光定量分析中，与理论α系数相比，NNFP 算法提高了非线性基体效应校正能力和预测准确度。%An algorithm of combining neural networks with the fundamental parameters(NNFP) was proposed and compared with the theoretical alpha coefficient based on classical matrix correction models. The results show that NNFP has more powerful ability of correcting the nonlinear matrix effects than the theoretical alpha coefficient and partial least-square regression(PLS) in X-ray fluorescence analysis.
唐艳秋; 孙强; 赵建; 姚凯男
2016-01-01
The advantages and disadvantages in nonuniformity correction (NUC) algorithms based on calibration and scene of infrared focal plane arrays(IRFPA) were analysed separately. The combined NUC algorithm was presented. The thermal imaging system extracted the gain and offset factor from the FLASH which storged beforehand according to the substrate temperature of the IRFPA at the moment of power on. These factor was adopted to remove the nonuniformity of the detector simply. Based on the analysis of the characteristic of residual noise after initial correction, the P-M filter was used to replace the linear spatial average filter in the Neural Network nonuniformity correction algorithm (NN-NUC), which could preserve the image edge. Experimental results show that the proposed algorithm can accelerate the rate of convergence, reduces the correction error largely, and avoids the image degradation caused by the response drift of IRFPA.%分别分析了红外焦平面阵列(IRFPA)基于定标的非均匀性校正法(NUC)和基于场景的NUC算法各自的优势和问题，在此基础上提出了联合非均匀性校正方法。根据上电时刻焦平面衬底的温度值，从FLASH中提取事先存储的对应温度区间的增益和偏置校正参数，初步消除探测器的非均匀性。通过分析初步校正后图像残余非均匀性噪声的特性，提出了用具有保边缘特性的P-M滤波取代传统神经网络算法中的四邻域均值滤波来获得期望图像，从而减小了图像边缘误差。实验结果表明，该算法收敛速度快，校正精度高，有效避免了因红外焦平面响应特性漂移而引起的图像降质。
Chromosome aberrations induced by zebularine in triticale.
Ma, Xuhui; Wang, Qing; Wang, Yanzhi; Ma, Jieyun; Wu, Nan; Ni, Shuang; Luo, Tengxiao; Zhuang, Lifang; Chu, Chenggen; Cho, Seong-Woo; Tsujimoto, Hisashi; Qi, Zengjun
2016-07-01
Chromosome engineering is an important approach for generating wheat germplasm. Efficient development of chromosome aberrations will facilitate the introgression and application of alien genes in wheat. In this study, zebularine, a DNA methylation transferase inhibitor, was successfully used to induce chromosome aberrations in the octoploid triticale cultivar Jinghui#1. Dry seeds were soaked in zebularine solutions (250, 500, and 750 μmol/L) for 24 h, and the 500 μmol/L treatment was tested in three additional treatment times, i.e., 12, 36, and 48 h. All treatments induced aberrations involving wheat and rye chromosomes. Of the 920 cells observed in 67 M1 plants, 340 (37.0%) carried 817 aberrations with an average of 0.89 aberrations per cell (range: 0-12). The aberrations included probable deletions, telosomes and acentric fragments (49.0%), large segmental translocations (28.9%), small segmental translocations (17.1%), intercalary translocations (2.6%), long chromosomes that could carry more than one centromere (2.0%), and ring chromosomes (0.5%). Of 510 M2 plants analyzed, 110 (21.6%) were found to carry stable aberrations. Such aberrations included 79 with varied rye chromosome numbers, 7 with wheat and rye chromosome translocations, 15 with possible rye telosomes/deletions, and 9 with complex aberrations involving variation in rye chromosome number and wheat-rye translocations. These indicated that aberrations induced by zebularine can be steadily transmitted, suggesting that zebularine is a new efficient agent for chromosome manipulation.
Spatial Light Modulator for wavefront correction
Vyas, Akondi; Banyal, Ravinder Kumar; Prasad, B Raghavendra
2009-01-01
We present a liquid crystal method of correcting the phase of an aberrated wavefront using a spatial light modulator. A simple and efficient lab model has been demonstrated for wavefront correction. The crux of a wavefront correcting system in an adaptive optics system lies in the speed and the image quality that can be achieved. The speeds and the accuracy of wavefront representation using Zernike polynomials have been presented using a very fast method of computation.
Marine High-voltage Motor Winding Dielectric Loss Angle Correction Algorithm%海洋高压电机绕组中介质损耗角的校正算法
李阳勤; 刘敬彪; 蔡文郁; 霍洪强
2015-01-01
This paper describes a marine high-pressure motor winding dielectric loss angle correction algorithm and outlines China's marine expedition equipments and the necessity of preventing insulation accidents in entire power system .Also it introduces the dielectric loss angle calculation process based on the harmonic analysis , and analyzes the error caused by the harmonic algorithm .Then proposed a correction method combing window leak and fence effect of disclosure—the use of Hamming window weighting function and the fast Fourier transform correction method , which corrects the frequency , amplitude and phase angle respectively .The value of the dielectric loss get from improved harmonic analysis method by the frequency fluctuation is very small , measured in the field .%介绍了一种海洋高压电机绕组中介质损耗角的校正算法。详述了基于谐波分析法的介质损耗角的计算过程，通过分析谐波算法带来的误差原因，根据误差主要原因窗泄露以及栅栏效应提出了将二者合二为一的校正方法，使用汉明窗加权函数和快速傅里叶变换的校正方法，分别对频率、幅值和相位角进行校正改进，改进的谐波分析法得出的介质损耗值受频率变化波动非常小，在现场测量中得到了充分的验证。
Atom lens without chromatic aberrations
Efremov, Maxim A; Schleich, Wolfgang P
2012-01-01
We propose a lens for atoms with reduced chromatic aberrations and calculate its focal length and spot size. In our scheme a two-level atom interacts with a near-resonant standing light wave formed by two running waves of slightly different wave vectors, and a far-detuned running wave propagating perpendicular to the standing wave. We show that within the Raman-Nath approximation and for an adiabatically slow atom-light interaction, the phase acquired by the atom is independent of the incident atomic velocity.
Abdoli, Mehrsima; Ay, Mohammad Reza; Ahmadian, Alireza; Dierckx, Rudi A. J. O.; Zaidi, Habib
2010-01-01
Purpose: The presence of metallic dental fillings is prevalent in head and neck PET/CT imaging and generates bright and dark streaking artifacts in reconstructed CT images. The resulting artifacts would propagate to the corresponding PET images following CT-based attenuation correction (CTAC). This
Adaptive variable selection for extended Nijboer-Zernike aberration retrieval via lasso
Wang, Bin; Diao, Huai-An; Guo, Jianhua; Liu, Xiyang; Wu, Yuanhao
2017-02-01
In this paper, we propose extended Nijboer-Zernike (ENZ) method for aberration retrieval by incorporating lasso variable selection method which can improve the accuracy of aberration retrieval. The proposed model is computed by the state-of-art algorithm of the Bregman iterative algorithm (Bregman, 1967 [1]; Cai et al., 2008 [2]; Yin et al., 2008 [3]) for L1 minimization problem with adaptive regularized parameter choice based on the strategy (Ito et al., 2011 [4]). Numerical simulations for real world and simulated phase data validate the effectiveness of the proposed ENZ AR via lasso.
周慧鑫; 拜丽萍; 秦翰林; 赖睿; 王炳健; 刘群昌
2009-01-01
The performance of nonuniformity correction(NUC) would be deteriorated by time shift in the response of detectors in infrared focal plane arrays(IRFPAs). Therefore, a scene-based NUC algorithm is presented. In this algorithm, an adaptive filter bank is applied to estimate NUC parameters for every detector in IRFPAs. And the parameters are renewed by utilizing current imaging information to reduce the influence imposed by response drift on NUC. For an image with a nonuniformity of 26.12%, nonuniformities after 1 h correction are 3.122% for two-point NUC algorithm, 1.893% for Kalman-filter NUC algorithm and around 1.856% for the presented algorithm, which means the presented algorithm can achieve the best NUC effect steadily.%红外探测器响应漂移特性会降低红外焦平面阵列(IRFPA)非均匀性校正的精度.针对该问题提出了一种基于场景的IRFPA非均匀性校正算法.该算法利用所获得的序列成像场景信息,采用一种基于快速自适应滤波器的最优化递归估计方法来获得非均匀性校正参数,并利用当前的成像信息来更新校正参数,以此降低探测器响应漂移特性对非均匀性校正的影响.算法仿真实验显示,对非线性参数为26.12%的同一图像,使用该算法、两点校正算法和卡尔曼滤波校正算法校正1 h后,可分别将非线性参数降至1.856%,3.122%和1.893%,说明该算法可获得稳定而较好的非均匀性校正效果.
钟州; 金梁; 黄开枝; 白慧卿; 易鸣
2013-01-01
该文通过分析安全编码的原理推导了安全间隙约束条件下高斯窃听信道保密速率的计算方法，并根据置信传播(Belief Propagation, BP)译码算法及其改进算法，针对基于中短码长LDPC码所设计的安全编码提出一种2维信息修正的分类归一化最小和译码算法。该算法先将输入校验节点信息绝对值分成最小值和次小值两类，然后在译码初始化时利用概率统计理论分别推导出相应的最佳归一化因子对分类后的信息进行修正。仿真结果表明，该算法在高信噪比区域的译码性能高于BP算法和归一化最小和算法，低信噪比区域误比特率迅速逼近0.5，且能减小不同安全编码速率LDPC码的安全间隙，提高了保密信息安全传输的性能。%This paper analyzes the mechanism of physical layer secrecy coding and calculates the secrecy rate for the Gaussian wiretap channel under the security gap constraint. Furthermore, a classified normalized decoding algorithm with two-dimensional information correction based on Belief Propagation (BP) algorithm and its improvements for the short and medium block length Low Density Parity Check (LDPC) based secrecy codes is presented. The algorithm first utilizes classification according to the absolute values of incoming messages in check nodes. Then it uses 2-dimensional normalization to correct the minimum and sub-minimum values. The 2-dimensional normalized factors can be calculated respectively by using probability and statistic theory in the initialization step. Simulation results show that the proposed algorithm achieves better performance than BP algorithm and normalized BP-based algorithm at the high SNR, but the bit error radio gets close to 0.5 rapidly at the low SNR. It can reduce security gap of LDPC-based secrecy codes with different secrecy rates efficiently.
The misalignment induced aberrations of TMA telescopes.
Thompson, Kevin P; Schmid, Tobias; Rolland, Jannick P
2008-12-08
The next major space-borne observatory, the James Webb Space Telescope, will be a 6.6M field-biased, obscured, three-mirror anastigmat (TMA). Over the used field of view, the performance of TMA telescopes is dominated by 3(rd) order misalignment aberrations. Here it is shown that two dominant 3(rd) order misalignment aberrations arise for any TMA telescope. One aberration, field constant 3(rd) order coma is a well known misalignment aberration commonly seen in two-mirror Ritchey Chretien telescopes. The second aberration, field-asymmetric, field-linear, 3(rd) order astigmatism is a new and unique image orientation dependence with field derived here for the first time using nodal aberration theory.
付锴; 雷勇; 颜嘉俊
2011-01-01
The traditional Multi-Dimensional Scaling ( MDS) algorithm adopts multi-hop distance to replace direct distance, resulting in low accuracy of the local network and large localization error in irregular network. Relative to the existing algorithms, the paper introduced the Euclidean algorithm to generate accurate multi-hop distance between nodes, and used weighting mechanism to improve the coefficient of stress. The simulation results show that in low connectivity rectangle network and C-shape network localization, this method acTheves better performance.%传统的多维定标(MDS)算法由于采用多跳距离代替节点间的直接距离,生成的局部网络准确度低,在不规则网络中定位误差大.相对于现有的算法,引入Euclidean方法来产生多跳节点间的准确距离,并采用一种加权机制来改进协强系数,以抑制累积误差.仿真结果表明该方法在C型网络和低连通度的矩形网络定位中能取得更好的效果.
Junlei Zhao
2017-01-01
Full Text Available It is necessary to know the distribution of the Chinese eye’s aberrations in clinical environment to guide high-resolution retinal imaging system design for large Chinese population application. We collected the monochromatic wave aberration of 332 healthy eyes and 344 diseased eyes in Chinese population across a 6.0-mm pupil. The aberration statistics of Chinese eyes including healthy eyes and diseased eyes were analyzed, and some differences of aberrations between the Chinese and European race were concluded. On this basis, the requirement for adaptive optics (AO correction of the Chinese eye’s monochromatic aberrations was analyzed. The result showed that a stroke of 20μm and ability to correct aberrations up to the 8th Zernike order were needed for reflective wavefront correctors to achieve near diffraction-limited imaging in both groups for a reference wavelength of 550nm and a pupil diameter of 6.0mm. To verify the analysis mentioned above, an AO flood-illumination system was established, and high-resolution retinal imaging in vivo was achieved for Chinese eye including both healthy and diseased eyes.
Chromatic aberration measurement for transmission interferometric testing.
Seong, Kibyung; Greivenkamp, John E
2008-12-10
A method of chromatic aberration measurement is described based on the transmitted wavefront of an optical element obtained from a Mach-Zehnder interferometer. The chromatic aberration is derived from transmitted wavefronts measured at five different wavelengths. Reverse ray tracing is used to remove induced aberrations associated with the interferometer from the measurement. In the interferometer, the wavefront transmitted through the sample is tested against a plano reference, allowing for the absolute determination of the wavefront radius of curvature. The chromatic aberrations of a singlet and a doublet have been measured.
汽车前轮转向角测试误差修正算法研究%Algorithm for correcting turning-angle test error of vehicle's front-wheel
张扬; 张晓光
2011-01-01
An algorithm to correct turning-angle test error for vehicle steering-wheel was described in this paper, it used the mechanical structure properties of vehicle steering-axle. By this algorithm, the zero turning-angle starting position of the steering-wheel can be accurately calculated, and then the turning-angle test data can be corrected. Furthermore, the accurate maximum turning angles and related angles of the left and the right steering-wheels can be calculated. It solves the problem that the turning -angle test data for, the steering -wheel has low accuracy and poor repeatability.%提出一种利用汽车转向桥机械结构特性解决汽车转向轮转向角测试误差修正的算法,通过该算法可计算出汽车轮胎准确的零转角起点位置,进而对转角测试数据进行修正,以此计算出准确的左右轮最大转向角及相关角,解决了目前汽车转向轮转向角测试数据准确度低、重复性差的问题.
Breaking the spherical and chromatic aberration barrier in transmission electron microscopy.
Freitag, B; Kujawa, S; Mul, P M; Ringnalda, J; Tiemeijer, P C
2005-02-01
Since the invention of transmission electron microscopy (TEM) in 1932 (Z. Physik 78 (1932) 318) engineering improvements have advanced system resolutions to levels that are now limited only by the two fundamental aberrations of electron lenses; spherical and chromatic aberration (Z. Phys. 101 (1936) 593). Since both aberrations scale with the dimensions of the lens, research resolution requirements are pushing the designs to lenses with only a few mm space in the pole-piece gap for the specimen. This is in conflict with the demand for more and more space at the specimen, necessary in order to enable novel techniques in TEM, such as He-cooled cryo electron microscopy, 3D-reconstruction through tomography (Science 302 (2003) 1396) TEM in gaseous environments, or in situ experiments (Nature 427 (2004) 426). All these techniques will only be able to achieve Angstrom resolution when the aberration barriers have been overcome. The spherical aberration barrier has recently been broken by introducing spherical aberration correctors (Nature 392 (1998) 392, 418 (2002) 617), but the correction of the remaining chromatic aberrations have proved to be too difficult for the present state of technology (Optik 57 (1980) 73). Here we present an alternative and successful method to eliminate the chromatic blur, which consists of monochromating the TEM beam (Inst. Phys. Conf. Ser. 161 (1999) 191). We show directly interpretable resolutions well below 1A for the first time, which is significantly better than any TEM operating at 200 KV has reached before.
Effect of methods of myopia correction on visual acuity, contrast sensitivity, and depth of focus
Nio, YK; Jansonius, NM; Wijdh, RHJ; Beekhuis, WH; Worst, JGF; Noorby, S; Kooijman, AC
2003-01-01
Purpose. To psychophysically measure spherical and irregular aberrations in patients with various types of myopia correction. Setting: Laboratory of Experimental Ophthalmology, University of Groningen, Groningen, The Netherlands. Methods: Three groups of patients with low myopia correction (spectacl
Practical comparison of aberration detection algorithms for biosurveillance systems.
Zhou, Hong; Burkom, Howard; Winston, Carla A; Dey, Achintya; Ajani, Umed
2015-10-01
National syndromic surveillance systems require optimal anomaly detection methods. For method performance comparison, we injected multi-day signals stochastically drawn from lognormal distributions into time series of aggregated daily visit counts from the U.S. Centers for Disease Control and Prevention's BioSense syndromic surveillance system. The time series corresponded to three different syndrome groups: rash, upper respiratory infection, and gastrointestinal illness. We included a sample of facilities with data reported every day and with median daily syndromic counts ⩾1 over the entire study period. We compared anomaly detection methods of five control chart adaptations, a linear regression model and a Poisson regression model. We assessed sensitivity and timeliness of these methods for detection of multi-day signals. At a daily background alert rate of 1% and 2%, the sensitivities and timeliness ranged from 24 to 77% and 3.3 to 6.1days, respectively. The overall sensitivity and timeliness increased substantially after stratification by weekday versus weekend and holiday. Adjusting the baseline syndromic count by the total number of facility visits gave consistently improved sensitivity and timeliness without stratification, but it provided better performance when combined with stratification. The daily syndrome/total-visit proportion method did not improve the performance. In general, alerting based on linear regression outperformed control chart based methods. A Poisson regression model obtained the best sensitivity in the series with high-count data.
Binocular adaptive optics visual simulator: understanding the impact of aberrations on actual vision
Fernández, Enrique J.; Prieto, Pedro M.; Artal, Pablo
2010-02-01
A novel adaptive optics system is presented for the study of vision. The apparatus is capable for binocular operation. The binocular adaptive optics visual simulator permits measuring and manipulating ocular aberrations of the two eyes simultaneously. Aberrations can be corrected, or modified, while the subject performs visual testing under binocular vision. One of the most remarkable features of the apparatus consists on the use of a single correcting device, and a single wavefront sensor (Hartmann-Shack). Both the operation and the total cost of the instrument largely benefit from this attribute. The correcting device is a liquid-crystal-on-silicon (LCOS) spatial light modulator. The basic performance of the visual simulator consists in the simultaneous projection of the two eyes' pupils onto both the corrector and sensor. Examples of the potential of the apparatus for the study of the impact of the aberrations under binocular vision are presented. Measurements of contrast sensitivity with modified combinations of spherical aberration through focus are shown. Special attention was paid on the simulation of monovision, where one eye is corrected for far vision while the other is focused at near distance. The results suggest complex binocular interactions. The apparatus can be dedicated to the better understanding of the vision mechanism, which might have an important impact in developing new protocols and treatments for presbyopia. The technique and the instrument might contribute to search optimized ophthalmic corrections.
徐晓苏; 吴剑飞; 徐胜保; 王立辉; 李佩娟
2014-01-01
ICCP匹配算法是水下组合导航系统中最为重要的匹配算法。针对传统ICCP匹配算法存在仅对水下航行器惯性导航系统指示航迹作旋转和平移的刚性变换的局限性问题，为提高水下航行器地形辅助导航系统中匹配算法的精度，分析了水下航行器惯性导航系统误差特性，建立了误差模型，提出了基于仿射修正技术的水下地形ICCP匹配算法。首先利用ICCP匹配算法对惯性导航系统指示航迹进行刚性变换，再利用最小二乘法求解仿射参数，进而对 ICCP 匹配航迹进行仿射修正。仿真研究表明，基于仿射修正技术的ICCP匹配算法能较好地解决传统ICCP匹配算法刚性变换的局限性，匹配精度优于传统ICCP算法，匹配误差小于数字地图网格间距的50%，同时仿射修正所耗费时间极少，所增加的时间仅为传统ICCP匹配算法匹配时间的千分之一。%ICCP is the most important matching algorithm used in underwater integrated navigation system. Traditional ICCP algorithm can only do rigid transformation (rotation and translation) for the indicated track of underwater vehicle’s INS. In order to overcome this problem and improve the accuracy of track matching, the error characteristics of INS are analyzed, and the error model of INS is established. Then a new ICCP algorithm based on affine correction is put forward. The track indicated by INS is transformed according to the ICCP algorithm. The affine parameters are solved with the least squares method. The ICCP matching track is modified by affine transformation. The simulations show that the defects of traditional ICCP algorithm can be avoided by affine correction, and the matching result is better than those of traditional ICCP algorithm, in which the matching error is less than 50% of digital map grid spacing. Meanwhile, the additional time consumed in affine correction is just about one thousandth of that in traditional ICCP
Aberrations of Gradient-Index Lenses.
Matthews, A. L.
Available from UMI in association with The British Library. In this thesis, the primary aberrations of lenses with a radial focussing gradient-of-index are analysed. Such a lens has a refractive index profile which decreases continuously and radially outward from the optical axis, so that the surfaces of constant refractive index are circular cylinders which are coaxial with the optical axis. Current applications of these lenses include photocopiers, medical endoscopes, telecommunications systems and compact disc systems. Closed formulae for the primary wavefront aberrations for a gradient-index lens with curved or plane entry and exit faces are obtained from the differential equations of such a lens to assess the primary transverse ray aberrations that it introduces. Identical expressions are then obtained by using the difference in optical path length produced between two rays by the lens. This duplication of the derivations of the primary wavefront aberrations acts as a confirmation of the validity of the expressions. One advantage of these equations is that the contributions due to the primary spherical aberration, coma, astigmatism, field curvature and distortion can be assessed individually. A Fortran 77 program has been written to calculate each of these individual contributions, the total primary wavefront aberrations and the primary transverse ray aberrations. Further confirmation of the validity of the expressions is obtained by using this program to show that the coma and distortion were both zero for fully symmetric systems working at unit magnification. The program is then used to assess the primary wavefront aberrations for a gradient-index lens which is currently of interest to the telecommunications industry. These results are compared with values obtained using a finite ray-tracing program for the total wavefront aberrations. This shows that the primary wavefront aberrations are the completely dominant contribution to the total wavefront
广角图像畸变校正算法的研究与实现%RESEARCH AND IMPLEMENTATION OF CORRECTION ALGORITHM FOR WIDE-ANGLE IMAGE DISTORTION
吴开兴; 段马丽; 张惠民; 王鹏
2014-01-01
为了校正广角图像的非线性畸变，提出一种新的数字校正方法来消除畸变。首先利用网格模板校正的方法，根据畸变图与理想图对应像素点的映射关系，得到畸变图像点在x轴和y轴方向上的偏移量。然后采用三次B插值函数对曲面插值，得到畸变像素点的偏移量曲面，由偏移量曲面和畸变点的坐标实现各像素点的坐标变换。最后通过双线性插值法完成灰度重建得到无畸变的图像，从而实现对广角图像的校正。为了测试该算法的速度性能和可靠性等指标，在DSP平台上运行此算法。实验结果表明该算法能够对广角畸变图像进行快速有效的校正。%In order to correct nonlinear distortion of wide-angle images, we propose a new digital correction method to eliminate the distortion.First, it makes use of grid template correction method to obtain the offset of distorted image points along X-and Y-axes directions according to the mapping relation between the corresponding pixels of distortion image and ideal figure.Then, it uses the cubic B-spline interpolation function to interpolate the surface, and gets the offset surface of the distorted pixels.According to the offset surface and the coordinate of distorted points, it realises the transformation of coordinate of each pixel.At last, a perfect image without distortion is obtained by the completion of grayscale reconstruction with bilinear interpolation, so as to achieve the correction on wide-angle images.In order to test the speed performance and the reliability of the algorithm, we run it on DSP platform.The experimental results show that this algorithm can make fast and effective correction on wide-angle distortion images.
Removing lateral chromatic aberration in bright field optical microscopy.
Guzmán-Altamirano, Miguel; Gutiérrez-Medina, Braulio
2015-06-01
We present an efficient alternative to remove lateral chromatic aberration (LCA) in bright field light microscopy images. Our procedure is based on error calibration using time-sequential acquisition at different wavelengths, and error correction through digital image warping. Measurement of the displacements of fiducial marks in the red and green images relative to blue provide calibration factors that are subsequently used in test images to realign color channels digitally. We demonstrate quantitative improvement in the position and boundaries of objects in target slides and in the color content and morphology of specimens in stained biological samples. Our results show a reduction of LCA content below the 0.1% level.
Psychometric Characteristics of the Aberrant Behavior Checklist.
Aman, Michael G.; And Others
1985-01-01
Information is presented on the psychometric characteristics of the Aberrant Behavior Checklist, a measure of psychotropic drug effects. Internal consistency and test-retest reliability of the checklist appeared very good. Interrater reliability was generally in the moderate range. In general, validity was established for most Aberrant Behavior…
Aberration coefficients of curved holographic optical elements
Verboven, P. E.; Lagasse, P. E.
1986-11-01
A general formula is derived that gives all aberration terms of holographic optical elements on substrates of any shape. The spherical substrate shape and the planar substrate shape are treated as important special cases. A numerical example illustrates the need of including higher-order aberrations.
冗余余数系统低复杂度快速纠错算法设计%Low-complexity Error Correction Algorithms for Redundant Residue Number Systems
2015-01-01
Redundant Residue Number System (RRNS) is widely used in communication systems for WLAN (Wireless LAN) and CDMA (Code Division Multiple Access) etc. due to its strong ability to enhance robustness of information in parallel processing environments. Error detection and correction of RRNS is an important guarantee for information reliability in communication systems. The overflow detection theorem, the unique theorem, and the searching theorem are proposed and proved in the paper based on properties of residue classes in finite rings. With the theorems, a single-error-correction algorithm using modular operations with reduced complexityO(k/r)is proposed. The uniqueness test algorithm is proposed. Furthermore, for any general types of errors, the searching multiple-error-correction algorithm is proposed. The computational complexity of the searching multiple-error- correction algorithm is reduced from polynomial order to logarithmic order according to the analysis, and the method can reach the extreme correction capability efficiently with only comparison operations instead of complex modular arithmetic.%余数系统由于具有增强传输信息在并行系统中鲁棒性的优势，已被广泛应用在无线局域网(WLAN)以及码分多址通信技术(CDMA)等领域。而余数系统中的纠错检错是保证传输数据可靠性和高效性的关键问题。该文根据有限环上剩余类的性质提出溢出判定定理，不重复判断定理和唯一性区间搜索定理，并在此基础上进一步提出采用模运算代替传统中国剩余定理进行快速恢复的单错误纠错算法，将复杂度降低为O (k/r )；提出不重复判定纠错算法；并对于一般错误情形，设计通过比较算子实现的搜索纠错算法。其中搜索纠错算法能直接实现系统最大纠错能力，且避免依靠复杂模运算算子实现，系统吞吐率得以提高；与传统算法相比，计算复杂度由多项式级降低至对数级。
Measuring chromatic aberrations in imaging systems using plasmonic nano-particles
Gennaro, Sylvain D; Maier, Stefan A; Oulton, Rupert F
2015-01-01
Chromatic aberration in optical systems arises from the wavelength dependence of a glass's refractive index. Polychromatic rays incident upon an optical surface are refracted at slightly different angles and in traversing an optical system follow distinct paths creating images displaced according to color. Although arising from dispersion, it manifests as a spatial distortion correctable only with compound lenses with multiple glasses and accumulates in complicated imaging systems. While chromatic aberration is measured with interferometry, simple methods are attractive for their ease of use and low cost. In this letter we retrieve the longitudinal chromatic focal shift of high numerical aperture (NA) microscope objectives from the extinction spectra of metallic nanoparticles within the focal plane. The method is accurate for high NA objectives with apochromatic correction, and enables rapid assessment of the chromatic aberration of any complete microscopy systems, since it is straightforward to implement
Repeatability of peripheral aberrations in young emmetropes.
Baskaran, Karthikeyan; Theagarayan, Baskar; Carius, Staffan; Gustafsson, Jörgen
2010-10-01
The purpose of this study is to assess the intrasession repeatability of ocular aberration measurements in the peripheral visual field with a commercially available Shack-Hartmann aberrometer (complete ophthalmic analysis system-high definition-vision research). The higher-order off-axis aberrations data in young healthy emmetropic eyes are also reported. The aberrations of the right eye of 18 emmetropes were measured using an aberrometer with an open field of view that allows peripheral measurements. Five repeated measures of ocular aberrations were obtained and assessed in steps of 10° out to ±40° in the horizontal visual field (nasal + and temporal -) and -20° in the inferior visual field. The coefficient of repeatability, coefficient of variation, and the intraclass correlation coefficient were calculated as a measure of intrasession repeatability. In all eccentric angles, the repeatability of the third- and fourth-order aberrations was better than the fifth and sixth order aberrations. The coefficient of variation was coefficient was >0.90 for the third and fourth order but reduced gradually for higher orders. There was no statistical significant difference in variance of total higher-order root mean square between on- and off-axis measurements (p > 0.05). The aberration data in this group of young emmetropes showed that the horizontal coma (C(3)(1)) was most positive at 40° in the temporal field, decreasing linearly toward negative values with increasing off-axis angle into the nasal field, whereas all other higher-order aberrations showed little or no change. The complete ophthalmic analysis system-high definition-vision research provides fast, repeatable, and valid peripheral aberration measurements and can be used efficiently to measure off-axis aberrations in the peripheral visual field.
Higher-Order Aberrations in Myopic Eyes
Farid Karimian
2010-01-01
Full Text Available Purpose: To evaluate the correlation between refractive error and higher-order aberrations (HOAs in patients with myopic astigmatism. Methods: HOAs were measured using the Zywave II aberrometer over a 6 mm pupil. Correlations between HOAs and myopia, astigmatism, and age were analyzed. Results: One hundred and twenty-six eyes of 63 subjects with mean age of 26.4±5.9 years were studied. Mean spherical equivalent refractive error and refractive astigmatism were -4.94±1.63 D and 0.96±1.06 D, respectively. The most common higher-order aberration was primary horizontal trefoil with mean value of 0.069±0.152 μm followed by spherical aberration (-0.064±0.130 μm and primary vertical coma (-0.038±0.148 μm. As the order of aberration increased from third to fifth, its contribution to total HOA decreased: 53.9% for third order, 31.9% for fourth order, and 14.2% for fifth order aberrations. Significant correlations were observed between spherical equivalent refractive error and primary horizontal coma (R=0.231, P=0.022, and root mean square (RMS of spherical aberration (R=0.213, P=0.031; between astigmatism and RMS of total HOA (R=0.251, P=0.032, RMS of fourth order aberration (R=0.35, P<0.001, and primary horizontal coma (R=0.314, P=0.004. Spherical aberration (R=0.214, P=0.034 and secondary vertical coma (R=0.203, P=0.031 significantly increased with age. Conclusion: Primary horizontal trefoil, spherical aberration and primary vertical coma are the predominant higher-order aberrations in eyes with myopic astigmatism.
具有半球形足端的六足机器人步态修正算法%Gait correction algorithm of hexapod walking robot with semi-round rigid feet
金波; 陈诚; 李伟
2013-01-01
Considered the body misplaced problem caused by the rolling effect of semi-round rigid feet during hexapod robot's walking period,a gait correction algorithm was established.The main benefits of the large radius semi-round structure were proposed,while the rolling effect during the supporting phase was illustrated.The concept of ideal foothold was put forward,with the 3D deviation between the ideal foothold and real foothold deduced by correcting the single leg kinematic model.The forward/inverse kinematic solutions between the ideal foothold and the joints' angular vectors were formulated.The root joint trajectory of single leg generated in simulation environment verifies the effectiveness of the algorithm.A series of walking experiments results show that the correction algorithm could improve the walking orientation deviation problem and the energetic cost obviously by avoiding foot slippage phenomenon as much as possible.%针对六足机器人步行时由于半球形足端滚动影响造成的机器人躯体轨迹偏差问题,提出一种步态修正算法.指出大半径半球形结构作为六足机器人的足端设计方案所具备的优势及其在支撑相中存在的足端滚动问题.通过提出理想立足点的概念,对三维空间内机器人单腿运动学模型进行修正,对理想立足点与实际立足点之间的偏差量进行分析,建立全方位步行时理想立足点与单腿各关节转角之间的运动学正/逆解关系.通过仿真对比分析修正前后单腿根关节运动轨迹,验证修正算法的有效性.实验结果表明,修正算法既能够更好地避免足端与地面产生相对滑动从而显著改善机器人步行时的方向偏离问题,又能够在一定程度上降低系统能耗.
2016-01-01
为了消除基于机器视觉的输送带故障在线监测系统中采集图像的不均匀光照影响,提高图像质量,检测出图像中的故障区域,提出了一种基于机器视觉的输送带图像校正和故障检测算法.该算法首先采用Butterworth低通滤波器对图像滤波,结合Retinex理论计算估计真实图像的背景,对图像进行灰度校正,得到校正后的图像;然后将机器视觉与生物视觉相结合,利用PCNN算法,对采集的图像进行检测,检测出故障区域.实验结果表明,算法能有效校正输送带表面图像,清晰检测出故障区域,具有很高的应用价值.%For the purposes of eliminating the influence of the non-uniform illumination which was used in on-line fault moni-toring system of conveyor belt based on machine vision and improved the quality of detected image and detecting the fault area of the image, a new kind of detection algorithm based on machine vision was proposed which can be used to realize the image correc-tion and fault detection of conveyor belt. The proposed algorithm firstly implemented the low-pass filtering of the acquired images by using Butterworth low-pass filter, then established estimated background model of the non-uniform illumination based on Retinex theory. Gray scale of the image can be amended evenly. Lastly, by using the combination the machine vision with biological vision and PNCC theory, the defected area of collected surface image of the conveyor belt was detected. Experimental results show that the proposed algorithm can be effectively used to correct the uneven gray scale of the surface images and detect the defected area of the surface image. It proves that this proposed algorithm has very high application value in mine belt conveyor supervision system.
A GPS Independent Geomagnetic Field Mapping and Correction Algorithm%不依赖GPS的磁图测绘与校正新方法
寇义民; 夏红伟; 刘睿; 王常虹
2011-01-01
针对水下磁场测绘中因载体难以经常上浮修正导航误差而导致的测绘结果坐标误差较大的问题,结合磁场测量的特殊性,并采用边导航边校正的思想,提出了一种不依赖GPS的全新磁图测绘方法.首先以惯性导航系统为标准进行第一次测绘并获得具有一定坐标误差的初始磁图,然后对初始磁图进行图形处理与信息提取,在此基础上进行第二次测绘.在第二次测绘中用从初始磁图获得的特征信息结合磁场传感器与惯性器件的输出构建卡尔曼滤波器,从而达到同时修正自身运动状态与初始磁图的目的.理论分析与仿真结果都证实了本方法可以通过两次误差较大的低精度测绘获得精度高得多的测绘结果.%A new algorithm for GPS independenl geomagnetic field mapping is developed in this paper. The idea from the SLAM ( simultaneous localization and mapping) method is implementted here, while several tricks are put forward to make the idea applicable. The algorithm is divided into three steps. Firstly, an inaccurate map is created with magnetic measurement data and position output from inertial navigation systems. Secondly, the map is analyzed and processed to extract shape information. Thirdly, another mapping process is carried out along the same route; meanwhile an extended Kalman filter is constructed by using the shape information of the original map, the status of the inertial navigation system, and the new measurement data. The initial mapping errors and the navigation errors will be estimated and adjusted together after the fiher' s convergence. Theoretical analysis and simulation results both prove that a much more accurate geomagnetic map can be built based on two inaccurate GPS independent surveys.
Analysis of the Aberration in Directly-writing Atom Lithography
LI Chuanwen; CAI Weiquan; WANG Yuzhu
2000-01-01
After deriving the approximation solution which describes the motion of neutral atoms in an optical standing wave field with large detuning, the spherical aberration and the chromatic aberration are analyzed and possible methods to reduce these aberrations are discussed.
Aberration-Coreected Electron Microscopy at Brookhaven National Laboratory
Zhu,Y.; Wall, J.
2008-04-01
The last decade witnessed the rapid development and implementation of aberration correction in electron optics, realizing a more-than-70-year-old dream of aberration-free electron microscopy with a spatial resolution below one angstrom [1-9]. With sophisticated aberration correctors, modern electron microscopes now can reveal local structural information unavailable with neutrons and x-rays, such as the local arrangement of atoms, order/disorder, electronic inhomogeneity, bonding states, spin configuration, quantum confinement, and symmetry breaking [10-17]. Aberration correction through multipole-based correctors, as well as the associated improved stability in accelerating voltage, lens supplies, and goniometers in electron microscopes now enables medium-voltage (200-300kV) microscopes to achieve image resolution at or below 0.1nm. Aberration correction not only improves the instrument's spatial resolution but, equally importantly, allows larger objective lens pole-piece gaps to be employed thus realizing the potential of the instrument as a nanoscale property-measurement tool. That is, while retaining high spatial resolution, we can use various sample stages to observe the materials response under various temperature, electric- and magnetic- fields, and atmospheric environments. Such capabilities afford tremendous opportunities to tackle challenging science and technology issues in physics, chemistry, materials science, and biology. The research goal of the electron microscopy group at the Dept. of Condensed Matter Physics and Materials Science and the Center for Functional Nanomaterials, as well as the Institute for Advanced Electron Microscopy, Brookhaven National Laboratory (BNL), is to elucidate the microscopic origin of the physical- and chemical-behavior of materials, and the role of individual, or groups of atoms, especially in their native functional environments. We plan to accomplish this by developing and implementing various quantitative
Explaining algorithms using metaphors
Forišek, Michal
2013-01-01
There is a significant difference between designing a new algorithm, proving its correctness, and teaching it to an audience. When teaching algorithms, the teacher's main goal should be to convey the underlying ideas and to help the students form correct mental models related to the algorithm. This process can often be facilitated by using suitable metaphors. This work provides a set of novel metaphors identified and developed as suitable tools for teaching many of the 'classic textbook' algorithms taught in undergraduate courses worldwide. Each chapter provides exercises and didactic notes fo
Chromosome aberration assays in Allium
Grant, W.F.
1982-01-01
The common onion (Allium cepa) is an excellent plant for the assay of chromosome aberrations after chemical treatment. Other species of Allium (A. cepa var. proliferum, A. carinatum, A. fistulosum and A. sativum) have also been used but to a much lesser extent. Protocols have been given for using root tips from either bulbs or seeds of Allium cepa to study the cytological end-points, such as chromosome breaks and exchanges, which follow the testing of chemicals in somatic cells. It is considered that both mitotic and meiotic end-points should be used to a greater extent in assaying the cytogenetic effects of a chemical. From a literature survey, 148 chemicals are tabulated that have been assayed in 164 Allium tests for their clastogenic effect. Of the 164 assays which have been carried out, 75 are reported as giving a positive reaction, 49 positive and with a dose response, 1 positive and temperature-related, 9 borderline positive, and 30 negative; 76% of the chemicals gave a definite positive response. It is proposed that the Allium test be included among those tests routinely used for assessing chromosomal damage induced by chemicals.
Kingston AC
2013-05-01
Full Text Available Amanda C Kingston,1,2 Ian G Cox11Bausch + Lomb, Rochester, NY, USA; 2Department of Biomedical Engineering, University of Rochester, Rochester, NY, USAPurpose: The aim of this analysis was to determine the total ocular wavefront aberration values of a large phakic population of physiologically normal, ametropic eyes, gathered under the same clinical protocol using the same diagnostic wavefront sensor.Materials and methods: Studies were conducted at multiple sites in Asia, North America, Europe, and Australia. A Bausch + Lomb Zywave II Wavefront Aberrometer (Rochester, NY, USA was used to measure the lower and higher order aberrations of each eye. Data analysis was conducted using linear regression analysis to determine the relationship between total spherical aberration, ametropia, age, corneal curvature, and image quality.Results: Linear regression analysis showed no correlation (r = 0.0207, P = 0.4874 between degree of ametropia and the amount of spherical aberration. There was also no correlation when the population was stratified into myopic and hyperopic refractive groups (rm = 0.0529, Pm = 0.0804 and rh = 0.1572, Ph = 0.2754. There was a statistically significant and weak positive correlation (r = 0.1962, P < 0.001 between age and the amount of spherical aberration measured in the eye; spherical aberration became more positive with increasing age. Also, there was a statistically significant and moderately positive correlation (r = 0.3611, P < 0.001 with steepness of corneal curvature; spherical aberration became more positive with increasing power of the anterior corneal surface. Assessment of image quality using optical design software (Zemax™, Bellevue, WA, USA showed that there was an overall benefit in correcting the average spherical aberration of this population.Conclusion: Analysis of this dataset provides insights into the inherent spherical aberration of a typical phakic, pre-presbyopic, population and provides the ability to
Aspherical lens design using hybrid neural-genetic algorithm of contact lenses.
Yen, Chih-Ta; Ye, Jhe-Wen
2015-10-01
The design of complex contact lenses involves numerous uncertain variables. How to help an optical designer to first design the optimal contact lens to reduce discomfort when wearing a pair of glasses is an essential design concern. This study examined the impact of aberrations on contact lenses to optimize a contact lens design for myopic and astigmatic eyes. In general, two aspherical surfaces can be assembled in an optical system to reduce the overall volume size. However, this design reduces the spherical aberration (SA) values at wide contact radii. The proposed optimization algorithm with optical design can be corrected to improve the SA value and, thus, reduce coma aberration (TCO) values and enhance the modulation transfer function (MTF). This means integrating a modified genetic algorithm (GA) with a neural network (NN) to optimize multiple-quality characteristics, namely the SA, TCO, and MTF, of contact lenses. When the proposed optional weight NN-GA is implemented, the weight values of the fitness function can be varied to adjust system performance. The method simplifies the selection of parameters in the optimization of optical systems. Compared with the traditional CODE V built-in optimal scheme, the proposed scheme is more flexible and intuitive to improve SA, TCO, and MTF values by 50.03%, 45.78%, and 24.7%, respectively.
Feasible optimal deformable mirror shaping algorithm for high-contrast imaging
Give'on, Amir; Kasdin, N. Jeremy; Vanderbei, Robert J.; Spergel, David N.; Littman, Michael G.; Gurfil, Pini
2003-12-01
The Princeton University Terrestrial Planet Finder (TPF) group has been working on a novel method for direct imaging of extra solar planets using a shaped-pupil coronagraph. The entrance pupil of the coronagraph is optimized to have a point spread function (PSF) that provides the suppression level needed at the angular separation required for detection of extra solar planets. When integration time is to be minimized, the photon count at the planet location in the image plane is a Poisson distributed random process. The ultimate limitation of these high-dynamic-range imaging systems comes from scattering due to imperfections in the optical surfaces of the collecting system. The first step in correcting the wavefront errors is the estimation of the phase aberrations. The phase aberration caused by these imperfections is assumed to be a sum of two-dimensional sinusoidal functions. Assuming one uses a deformable mirror to correct these aberrations, we propose an algorithm that optimally decreases the scattering level in specified localized areas in the image plane independent of the choice of influence function of the deformable mirror.
刘善梅; 李小昱; 钟雄斌
2014-01-01
In order to improve the generality of the water content hyperspectral calibration model for different varieties of cold fresh pork, a new hyperspectral signal correction algorithm called a variety sensitive wavelength selection combining with piecewise direct standardization (VSWS-PDS) is proposed. The variety sensitive wavelengths were first selected, based on a regression coefficient of the partial least square regression (PLSR) model, then the piecewise direct standardization(PDS) algorithm was utilized to correct the selected wavelengths and to eliminate the impact of variety difference on model prediction results. The detailed process of the VSWS-PDS algorithm is illustrated as follows: (1) The samples of the “master” variety were divided into calibration set mC and prediction set mP by utilizing the Kennard and Stone(KS) algorithms. (2) A PLSR model named PLSR1 was built with a calibration set mC. (3) A small quantity of representative“slave”variety samples selected from“slave”variety samples by utilizing sample set partitioning based on a joint X-Y distances (SPXY) algorithm were added to mC,and then a new PLSR model named PLSR2 was built. (4) The variety sensitive wavelengths were selected on the basis of the relative difference between the regression coefficients of model PLSR1 and PLSR2. (5) The standardization samples mTC were selected among the calibration samples mC by utilizing the KS algorithm, then the Euclidean distances between the physical or chemical reference values of the sample set mTC and all of the“slave”variety samples were calculated one by one, the“slave”variety samples with the minimum distance from mTC were chosen as standardization samples, yielding sTC, and the rest, yielding sP. (6) The average spectrum of mTC and sTC was calculated, yielding mTmean and sTmean. If wavelength i was variety sensitive, a new spectrum matrix Zi was reconstructed from sTmean in a small window from i-k to i+k, a multiple linear
Matkivsky, V. A.; Moiseev, A. A.; Shilyagin, P. A.; Shabanov, D. V.; Gelikonov, G. V.; Gelikonov, V. M.
2016-11-01
We propose a new method of compensating for the wavefront aberrations during the image processing. The method employs the digital-holography potential. The developed algorithms allow one to find the wavefront distortions caused by the optical-path nonuniformities during the interference recording of images without additional measurements (i.e., without using the reference point source and measuring the wavefront distortions). The possibility of decreasing the wavefront aberrations from tens to several radians using digital methods is demonstrated.
Demonstrating optical aberrations in the laboratory
Naidoo, Darryl
2009-07-01
Full Text Available in the laboratory D. Naidoo1,2 , C. Mafusire1,2 and A. Forbes1,2 1 CSIR National Laser Centre 2 School of Physics, University of KwaZulu-Natal AN OPTICAL ABERRATION IS A DISTORTION OF AN IMAGE AS COMPARED TO THE OBJECT DUE TO DEFECTS IN AN OPTICAL SYSTEM TILT... COEFFICIENT ODDWEIGHTING EVEN ODD ABERRATION PHASE EVENWEIGHTING COEFFICIENT COEFFICIENT ZERNIKE POLYNOMIALS ARE FITTED TO 3-DIMENSIONAL DATA TO DESCRIBE THE ABERRATIONS OF WAVEFRONT MEASUREMENTS IMPORTANT ELEMENTS OF DESIGN INCLUDE A LENSLET ARRAY...
Thompson, Kevin P
2010-06-01
Building on an earlier work on the nodal aberration theory of the 3rd-order aberrations [J. Opt. Soc. Am. A22, 1389 (2005)] and the first paper in this series on the nodal aberration theory of higher-order aberrations [J. Opt. Soc. Am. A26, 1090 (2009)], this paper continues the derivation and presentation of the intrinsic, characteristic, often multinodal geometry for each type/family of the 3rd- and 5th-order optical aberrations as categorized by parallel developments for rotationally symmetric optics. The first paper in this series on the higher-order terms developed the nodal properties of the spherical aberration family, including W(060), W(240M), and W(242), and for completeness 7th-order spherical aberration W(080). This second paper in the series develops and presents the intrinsic, characteristic, often multinodal properties of the family of comatic aberrations through 5th order, specifically W(151), W(331M), and W(333) [field-linear, 5th-order aperture coma; field-cubed, 3rd-order aperture coma; and field-cubed, elliptical coma (a 3rd-order in aperture 5th-order vector aberration)]. This paper will present the first derivations of trinodal aberrations by the author.
Zheng, C.L. [Monash Centre for Electron Microscopy, Monash University, Victoria 3800 (Australia); Etheridge, J., E-mail: joanne.etheridge@monash.edu [Monash Centre for Electron Microscopy, Monash University, Victoria 3800 (Australia); Department of Materials Engineering, Monash University, Victoria 3800 (Australia)
2013-02-15
A simple method is described for the accurate and precise measurement of chromatic aberration under electron-optical conditions pertinent to scanning transmission electron microscopy (STEM) and scanning confocal electron microscopy (SCEM). The method requires only the measurement of distances in a coherent CBED pattern and knowledge of the electron wavelength and the lattice spacing of a calibration specimen. The chromatic aberration of a spherical-aberration corrected 300 kV thermal field emission TEM is measured in STEM and SCEM operating modes and under different condenser lens settings. The effect of the measured chromatic aberrations on the 3 dimensional intensity distribution of the electron probe is also considered. - Highlights: ► A method is presented to measure chromatic aberration (C{sub c}) using coherent CBED. ► The C{sub c} of the probe and imaging lens systems in STEM and SCEM modes is measured in a C{sub 3}-corrected S/TEM. ► The effect of the measured C{sub c} on the depth resolution in STEM is simulated for different energy spreads.
Goodchild, Martin; Janes, Stuart; Jenkins, Malcolm; Nicholl, Chris; Kühn, Karl
2015-04-01
The aim of this work is to assess the use of temperature corrected substrate moisture data to improve the relationship between environmental drivers and the measurement of substrate moisture content in high porosity soil-free growing environments such as coir. Substrate moisture sensor data collected from strawberry plants grown in coir bags installed in a table-top system under a polytunnel illustrates the impact of temperature on capacitance-based moisture measurements. Substrate moisture measurements made in our coir arrangement possess the negative temperature coefficient of the permittivity of water where diurnal changes in moisture content oppose those of substrate temperature. The diurnal substrate temperature variation was seen to range from 7° C to 25° C resulting in a clearly observable temperature effect in substrate moisture content measurements during the 23 day test period. In the laboratory we measured the ML3 soil moisture sensor (ThetaProbe) response to temperature in Air, dry glass beads and water saturated glass beads and used a three-phase alpha (α) mixing model, also known as the Complex Refractive Index Model (CRIM), to derive the permittivity temperature coefficients for glass and water. We derived the α value and estimated the temperature coefficient for water - for sensors operating at 100MHz. Both results are good agreement with published data. By applying the CRIM equation with the temperature coefficients of glass and water the moisture temperature coefficient of saturated glass beads has been reduced by more than an order of magnitude to a moisture temperature coefficient of
Numerical nonwavefront-guided algorithm for expansion or recentration of the optical zone
Arba Mosquera, Samuel; Verma, Shwetabh
2014-08-01
Complications may arise due to the decentered ablations during refractive surgery, resulting from human or mechanical errors. Decentration may cause over-/under-corrections, with patients complaining about seeing glares and halos after the procedure. Customized wavefront-guided treatments are often used to design retreatment procedures. However, due to the limitations of wavefront sensors in precisely measuring very large aberrations, some extreme cases may suffer when retreated with wavefront-guided treatments. We propose a simple and inexpensive numerical (nonwavefront-guided) algorithm to recenter the optical zone (OZ) and to correct the refractive error with minimal tissue removal. Due to its tissue-saving capabilities, this method can benefit patients with critical residual corneal thickness. Based on the reconstruction of ablation achieved in the first surgical procedure, we calculate a target ablation (by manipulating the achieved OZ) with adequate centration and an OZ sufficient enough to envelope the achieved ablation. The net ablation map for the retreatment procedure is calculated from the achieved and target ablations and is suitable to expand, recenter, and modulate the lower-order refractive components in a retreatment procedure. The results of our simulations suggest minimal tissue removal with OZ centration and expansion. Enlarging the OZ implies correcting spherical aberrations, whereas inducing centration implies correcting coma. This method shows the potential to improve visual outcomes in extreme cases of retreatment, possibly serving as an uncomplicated and inexpensive alternative to wavefront-guided retreatments.
Li, Qianwen, E-mail: qianwen18@126.com; Li, Pengyu, E-mail: lipyu818@gmail.com; Su, Zhuangzhi, E-mail: suzhuangzhi@xwh.ccmu.edu.cn; Yao, Xinyu, E-mail: 314985151@qq.com; Wang, Yan, E-mail: wy19851121@126.com; Wang, Chen, E-mail: fskwangchen@gmail.com; Du, Xiangying, E-mail: duxying_xw@163.com; Li, Kuncheng, E-mail: kuncheng.li@gmail.com
2014-11-15
-segment analysis, IQS was improved in most segments (9/14). Conclusion: The SSF algorithm can provide acceptable diagnostic image quality in coronary CTA for patients with intermediate HR.
祖文超; 苑津莎; 王峰; 刘磊
2012-01-01
In order to enhance the accuracy rate of transformer fault diagnosis,multiclass classification algorithm,which is based upon Error-correcting codes connects with SVM,has been proposedThe mathe-matical model of transformer fault diagnosis is set up according to the theory of Support Vector Machine. Firstly,the Error-correcting codes matrix constructs some irrelevant Support Vector Machine,so that the accuracy rate of classified model can be enhanced.Finally,taking the dissolved gases in the transformer oil as the practise and testing sample of Error-correcting codes and SVM to realize transformer fault diagno- sis.And checking the arithmetic by using UCI data.The multiclass classification algorithm has been verified through VS2008 combined with Libsvm has been verified.And the result shows the method has high ac- curacy of classification.%为了提高变压器故障诊断的准确率,提出了一种基于纠错编码和支持向量机相结合的多分类算法,根据SVM理论建立变压器故障诊断数学模型,首先基于纠错编码矩阵构造出若干个互不相关的子支持向量机,以提高分类模型的分类准确率。最后把变压器油中溶解气体（DGA）作为纠错编码支持向量机的训练以及测试样本,实现变压器的故障诊断,同时用UCI数据对该算法进行验证。通过VS2008和Libsvm相结合对其进行验证,结果表明该方法具有很高的分类精度。
Flow cytometric detection of aberrant chromosomes
Gray, J.W.; Lucas, J.; Yu, L.C.; Langlois, R.
1983-05-11
This report describes the quantification of chromosomal aberrations by flow cytometry. Both homogeneously and heterogeneously occurring chromosome aberrations were studied. Homogeneously occurring aberrations were noted in chromosomes isolated from human colon carcinoma (LoVo) cells, stained with Hoechst 33258 and chromomycin A3 and analyzed using dual beam flow cytometry. The resulting bivariate flow karyotype showed a homogeneously occurring marker chromosome of intermediate size. Heterogeneously occurring aberrations were quantified by slit-scan flow cytometry in chromosomes isolated from control and irradiated Chinese hamster cells and stained with propidium iodide. Heterogeneously occurring dicentric chromosomes were detected by their shapes (two centrometers). The frequencies of such chromosomes estimated by slit-scan flow cytometry correlated well with the frequencies determined by visual microscopy.
Individual eye model based on wavefront aberration
Guo, Huanqing; Wang, Zhaoqi; Zhao, Qiuling; Quan, Wei; Wang, Yan
2005-03-01
Based on the widely used Gullstrand-Le Grand eye model, the individual human eye model has been established here, which has individual corneal data, anterior chamber depth and the eyeball depth. Furthermore, the foremost thing is that the wavefront aberration calculated from the individual eye model is equal to the eye's wavefront aberration measured with the Hartmann-shack wavefront sensor. There are four main steps to build the model. Firstly, the corneal topography instrument was used to measure the corneal surfaces and depth. And in order to input cornea into the optical model, high-order aspheric surface-Zernike Fringe Sag surface was chosen to fit the corneal surfaces. Secondly, the Hartmann-shack wavefront sensor, which can offer the Zernike polynomials to describe the wavefront aberration, was built to measure the wavefront aberration of the eye. Thirdly, the eye's axial lengths among every part were measured with A-ultrasonic technology. Then the data were input into the optical design software-ZEMAX and the crystalline lens's shapes were optimized with the aberration as the merit function. The individual eye model, which has the same wavefront aberrations with the real eye, is established.
过采样滤波器组作为纠错码的阈值新算法%NEW THRESHOLD ALGORITHM WITH OFBS AS ERROR-CORRECTION CODE
黄晓红; 高荣蔓
2015-01-01
考虑量化噪声和信道噪声，搭建基于过采样滤波器组 OFBS（Oversampled Filter Banks）的联合信源信道编码系统，研究系统的传输检错纠错性能。提出新的阈值选取方法，该方法是基于贝叶斯假设检验为理论依据的，能根据实际信号和噪声统计特性做实时分析，得出适当的阈值。通过 Matlab 对系统进行仿真，结果表明信道在不同的转移概率条件，OFBS 作为纠错码的阈值新算法的计算复杂度低，并且有很好的检错纠错性能。通过对一维信号的纠错，信号的峰值信噪比平均提高1到2 db。%Considering the quantisation noise and channel noise,we construct OFBS-based joint source-channel coding (JSCC)system, and study the performance of transmission error detection and correction of the system.We also propose a new threshold selection method, which is based on Bayesian hypothesis testing and takes it for the theoretical basis,it can carry out real-time analysis according to practical signal and noise statistical characteristics to obtain the proper threshold.The system is simulated with Matlab,results show that when channel is under different transition probability conditions,the new threshold algorithm using OFBS as error-correcting codes has low computational complexity,and has good error correction performance as well.Through error correction on one-dimensional signal,the peak signal-noise ratio of the signal improves 1 db to 2 db in average.
Perceived no reference image quality measurement for chromatic aberration
Lamb, Anupama B.; Khambete, Madhuri
2016-03-01
Today there is need for no reference (NR) objective perceived image quality measurement techniques as conducting subjective experiments and making reference image available is a very difficult task. Very few NR perceived image quality measurement algorithms are available for color distortions like chromatic aberration (CA), color quantization with dither, and color saturation. We proposed NR image quality assessment (NR-IQA) algorithms for images distorted with CA. CA is mostly observed in images taken with digital cameras, having higher sensor resolution with inexpensive lenses. We compared our metric performance with two state-of-the-art NR blur techniques, one full reference IQA technique and three general-purpose NR-IQA techniques, although they are not tailored for CA. We used a CA dataset in the TID-2013 color image database to evaluate performance. Proposed algorithms give comparable performance with state-of-the-art techniques in terms of performance parameters and outperform them in terms of monotonicity and computational complexity. We have also discovered that the proposed CA algorithm best predicts perceived image quality of images distorted with realistic CA.
Adaptive Alternating Minimization Algorithms
Niesen, Urs; Wornell, Gregory
2007-01-01
The classical alternating minimization (or projection) algorithm has been successful in the context of solving optimization problems over two variables or equivalently of finding a point in the intersection of two sets. The iterative nature and simplicity of the algorithm has led to its application to many areas such as signal processing, information theory, control, and finance. A general set of sufficient conditions for the convergence and correctness of the algorithm is quite well-known when the underlying problem parameters are fixed. In many practical situations, however, the underlying problem parameters are changing over time, and the use of an adaptive algorithm is more appropriate. In this paper, we study such an adaptive version of the alternating minimization algorithm. As a main result of this paper, we provide a general set of sufficient conditions for the convergence and correctness of the adaptive algorithm. Perhaps surprisingly, these conditions seem to be the minimal ones one would expect in ...
A general algorithm for distributing information in a graph
Aji, Srinivas M.; McEliece, Robert J.
1997-01-01
We present a general “message-passing” algorithm for distributing information in a graph. This algorithm may help us to understand the approximate correctness of both the Gallager-Tanner-Wiberg algorithm, and the turbo-decoding algorithm.
2016-06-07
REFERENCE ONLY NAVAL U~DERWATER SYSTEMS CENTER NEW LONDON LABORATORY NEW LONDON, CONNECTICUT 06320 Technical Memorandum SIMAS ADM XBT ALGORITHM ...REPORT TYPE Technical Memo 3. DATES COVERED 05-12-1984 to 05-12-1984 4. TITLE AND SUBTITLE SIMAS ADM XBT Algorithm 5a. CONTRACT NUMBER 5b...NOTES NUWC2015 14. ABSTRACT An algorithm has been developed for the detection and correction of surface ship launched expendable bathythermograph
Marois, C; Marois, Christian; Macintosh, Don W. Phillion & Bruce
2006-01-01
Imaging faint companions (exoplanets and brown dwarfs) around nearby stars is currently limited by speckle noise. To efficiently attenuate this noise, a technique called simultaneous spectral differential imaging (SSDI) can be used. This technique consists of acquiring simultaneously images of the field of view in several adjacent narrow bands and in combining these images to suppress speckles. Simulations predict that SSDI can achieve, with the acquisition of three wavelengths, speckle noise attenuation of several thousands. These simulations are usually performed using the Fraunhofer approximation, i.e. considering that all aberrations are located in the pupil plane. We have performed wavefront propagation simulations to evaluate how out-of-pupil-plane aberrations affect SSDI speckle noise attenuation performance. The Talbot formalism is used to give a physical insight of the problem; results are confirmed using a proper wavefront propagation algorithm. We will show that near-focal-plane aberrations can sig...
尹楠; 顾济华; 邹丽新; 周强; 马心儒
2013-01-01
An adaptive correction algorithm is proposed in this paper to correct the distorted linear CCD images when the athletes reach the finish line in a track competition. Firstly, the head inclination and aspect ratio of the athletes are got by using morphological processing for obtaining the transformation factor corresponding to the angle. Then the athlete head is taken as a center, and the appropriate length in the horizontal direction is selected to get the edge abscissa in the horizontal direction to the athlete, and clip the image. The two-dimensional transform matrixes are adopted to make the interpolation projective transfor-mation of the image. The simulation result shows that this algorithm is easy to implement and can restore the distorted images. The satisfying result can be obtained through simulation analysis on the stretch of the normal images.%针对田径比赛中运动员到达终点时线阵CCD采集到的失真图像进行处理,通过对扫描同步的分析,得到了失真图像产生原因,提出了一种自适应的校正算法.首先经形态学处理得到运动员头部的倾角及长宽比,进而得到对应角度的变换因子；然后以头部为中心,在水平方向左右取合适长度,得到运动员水平方向上的边缘横坐标并剪裁图像；最后使用二维变换矩阵对该图像进行插值投影变换.仿真实验表明,该算法简单易行,能较好地还原失真图像.并且通过对正常图像拉伸的仿真分析,得到较为满意的结果.
Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype
Ignatova Zoya
2007-09-01
Full Text Available Abstract Background A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level. Results We propose a new finite state machine able to detect and correct aberrant molecular phenotype given by mutated genetic transcripts. The aberrant mutations trigger a cascade reaction: specific molecular markers as input are released and induce a spontaneous self-assembly of a wild type protein or peptide, while the mutational disease phenotype is silenced. We experimentally demostrated in in vitro translation system that a viable protein can be autonomously assembled. Conclusion Our work demostrates the basic principles of computational genes and particularly, their potential to detect mutations, and as a response thereafter administer an output that suppresses the aberrant disease phenotype and/or restores the lost physiological function.
Kang, Sungsam; Kang, Pilsung; Yang, Taeseok D; Ahn, Joonmo; Song, Kyungdeok; Choi, Wonshik
2016-01-01
Thick biological tissues give rise to not only the scattering of incoming light waves, but also aberrations of the remaining unscattered waves. Due to the inability of existing optical imaging methodologies to overcome both of these problems simultaneously, imaging depth at the sub- micron spatial resolution has remained extremely shallow. Here we present an experimental approach for identifying and eliminating aberrations even in the presence of strong multiple light scattering. For time-gated complex-field maps of reflected waves taken over various illumination channels, we identify two sets of aberration correction maps, one for the illumination path and one for the reflection path, that can preferentially accumulate the unscattered signal waves over the multiple-scattered waves. By performing closed-loop optimization for forward and phase- conjugation processes, we demonstrated a spatial resolution of 600 nm up to the unprecedented imaging depth of 7 scattering mean free paths.
Wang, Jinyu; Léger, Jean-François; Binding, Jonas; Boccara, A Claude; Gigan, Sylvain; Bourdieu, Laurent
2012-10-01
Aberrations limit the resolution, signal intensity and achievable imaging depth in microscopy. Coherence-gated wavefront sensing (CGWS) allows the fast measurement of aberrations in scattering samples and therefore the implementation of adaptive corrections. However, CGWS has been demonstrated so far only in weakly scattering samples. We designed a new CGWS scheme based on a Linnik interferometer and a SLED light source, which is able to compensate dispersion automatically and can be implemented on any microscope. In the highly scattering rat brain tissue, where multiply scattered photons falling within the temporal gate of the CGWS can no longer be neglected, we have measured known defocus and spherical aberrations up to a depth of 400 µm.
Mitchell Guttman
2007-08-01
-channel BAC arrays using an amplification protocol. We demonstrate the accurate detection on simulated data, and on real datasets involving known regions of aberration within subtypes of breast cancer at a resolution consistent with that of the array. Similarly, we apply our method to previously published datasets, including a 250K SNP array, and verify known results as well as detect novel regions of concordant aberration. The algorithm has been fully implemented and tested and is freely available as a Java application at http://www.cbil.upenn.edu/MSA.
Tal Shay
2009-01-01
Full Text Available Many types of tumors exhibit characteristic chromosomal losses or gains, as well as local amplifications and deletions. Within any given tumor type, sample specific amplifications and deletions are also observed. Typically, a region that is aberrant in more tumors, or whose copy number change is stronger, would be considered as a more promising candidate to be biologically relevant to cancer. We sought for an intuitive method to define such aberrations and prioritize them. We define V, the “volume” associated with an aberration, as the product of three factors: (a fraction of patients with the aberration, (b the aberration’s length and (c its amplitude. Our algorithm compares the values of V derived from the real data to a null distribution obtained by permutations, and yields the statistical significance (p-value of the measured value of V. We detected genetic locations that were significantly aberrant, and combine them with chromosomal arm status (gain/loss to create a succinct fingerprint of the tumor genome. This genomic fingerprint is used to visualize the tumors, highlighting events that are co-occurring or mutually exclusive. We apply the method on three different public array CGH datasets of Medulloblastoma and Neuroblastoma, and demonstrate its ability to detect chromosomal regions that were known to be altered in the tested cancer types, as well as to suggest new genomic locations to be tested. We identified a potential new subtype of Medulloblastoma, which is analogous to Neuroblastoma type 1.
Ju, Guohao; Yan, Changxiang; Gu, Zhiyuan; Ma, Hongcai
2016-05-01
In active optics systems, one concern is how to quantitatively separate the effects of astigmatic and trefoil figure errors and misalignments that couple together in determining the total aberration fields when wavefront measurements are available at only a few field points. In this paper, we first quantitatively describe the impact of mount-induced trefoil deformation on the net aberration fields by proposing a modified theoretical formulation for the field-dependent aberration behavior of freeform surfaces based on the framework of nodal aberration theory. This formulation explicitly expresses the quantitative relationships between the magnitude of freeform surfaces and the induced aberration components where the freeform surfaces can be located away from the aperture stop and decentered from the optical axis. On this basis, and in combination with the mathematical presentation of nodal aberration theory for the effects of misalignments, we present the analytic expressions for the aberration fields of two-mirror telescopes in the presence of astigmatic primary mirror figure errors, mount-induced trefoil deformations on both mirrors, and misalignments. We quantitatively separate these effects using the analytical expressions with wavefront measurements at a few field points and pointing errors. Valuable insights are provided on how to separate these coupled effects in the computation process. Monte Carlo simulations are conducted to demonstrate the correctness and accuracy of the analytic method presented in this paper.
Brenton A
2017-05-01
Full Text Available Ashley Brenton,1 Steven Richeimer,2,3 Maneesh Sharma,4 Chee Lee,1 Svetlana Kantorovich,1 John Blanchard,1 Brian Meshkin1 1Proove Biosciences, Irvine, CA, 2Keck school of Medicine, University of Southern California, Los Angeles, CA, 3Departments of Anesthesiology and Psychiatry, University of Southern California, Los Angeles, CA, 4Interventional Pain Institute, Baltimore, MD, USA Background: Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. Purpose: This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated single-nucleotide polymorphisms (SNPs. Patients and methods: The Proove Opioid Risk (POR algorithm determines the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated SNPs. In a validation study with 258 subjects with diagnosed opioid use disorder (OUD and 650 controls who reported using opioids, the POR successfully categorized patients at high and moderate risks of opioid misuse or abuse with 95.7% sensitivity. Regardless of changes in the prevalence of opioid misuse or abuse, the sensitivity of POR remained >95%. Conclusion: The POR correctly stratifies patients into low-, moderate-, and high-risk categories to appropriately identify patients at need for additional guidance, monitoring, or treatment changes. Keywords: opioid use disorder, addiction, personalized medicine, pharmacogenetics, genetic testing, predictive algorithm
Higher order aberrations in amblyopic children and their role in refractory amblyopia
Arnaldo Dias-Santos
2014-12-01
Full Text Available Objective: Some studies have hypothesized that an unfavourable higher order aberrometric profile could act as an amblyogenic mechanism and may be responsible for some amblyopic cases that are refractory to conventional treatment or cases of “idiopathic” amblyopia. This study compared the aberrometric profile in amblyopic children to that of children with normal visual development and compared the aberrometric profile in corrected amblyopic eyes and refractory amblyopic eyes with that of healthy eyes. Methods: Cross-sectional study with three groups of children – the CA group (22 eyes of 11 children with unilateral corrected amblyopia, the RA group (24 eyes of 13 children with unilateral refractory amblyopia and the C group (28 eyes of 14 children with normal visual development. Higher order aberrations were evaluated using an OPD-Scan III (NIDEK. Comparisons of the aberrometric profile were made between these groups as well as between the amblyopic and healthy eyes within the CA and RA groups. Results: Higher order aberrations with greater impact in visual quality were not significantly higher in the CA and RA groups when compared with the C group. Moreover, there were no statistically significant differences in the higher order aberrometric profile between the amblyopic and healthy eyes within the CA and RA groups. Conclusions: Contrary to lower order aberrations (e.g., myopia, hyperopia, primary astigmatism, higher order aberrations do not seem to be involved in the etiopathogenesis of amblyopia. Therefore, these are likely not the cause of most cases of refractory amblyopia.
Relativistic stellar aberration for the Space Interferometry Mission
Turyshev, S G
2002-01-01
This paper analyses the relativistic stellar aberration requirements for the Space Interferometry Mission (SIM). We address the issue of general relativistic deflection of light by the massive self-gravitating bodies. Specifically, we present estimates for corresponding deflection angles due to the monopole components of the gravitational fields of a large number of celestial bodies in the solar system. We study the possibility of deriving an additional navigational constraints from the need to correct for the gravitational bending of light that is traversing the solar system. It turns out that positions of the outer planets presently may not have a sufficient accuracy for the precision astrometry. However, SIM may significantly improve those simply as a by-product of its astrometric program. We also consider influence of the higher gravitational multipoles, notably the quadrupole and the octupole ones, on the gravitational bending of light. Thus, one will have to model and account for their influence while o...
Propagation of Aberrations through Phase Induced Amplitude Apodization coronagraph
Pueyo, Laurent; Shaklan, Stuart; 10.1364/JOSAA.28.000189
2011-01-01
The specification of polishing requirements for the optics in coronagraphs dedicated to exo-planet detection requires careful and accurate optical modelling. Numerical representations of the propagation of aberrations through the system as well as simulations of the broadband wavefront compensation system using multiple DMs are critical when one devises an error budget for such a class of instruments. In this communication we introduce an analytical tool that serves this purpose for Phase Induced Amplitude Apodisation (PIAA) coronagraphs. We first start by deriving the analytical form of the propagation of a harmonic ripple through a PIAA unit. Using this result we derive the chromaticity of the field at any plane in the optical train of a telescope equipped with such a coronagraph. Finally we study the chromatic response of a sequential DM wavefront actuator correcting such a corrugated field and thus quantify the requirements on the manufacturing of PIAA mirrors
Prenatal hydronephrosis caused by aberrant renal vessels
Lenz, K; Thorup, Jørgen Mogens; Rabol, A;
1996-01-01
With routine use of obstetric ultrasonography, fetal low-grade hydronephrosis is commonly detected, but may resolve spontaneously after birth. Two cases are presented to illustrate that in some cases such findings can express intermittent hydronephrosis caused by aberrant renal vessels. Renal...
Functional Analysis and Treatment of Aberrant Behavior.
Mace, F. Charles; And Others
1991-01-01
This article reviews general classes of variables which help to maintain aberrant behavior including attention seeking, sensory and perceptual consequences, and access to materials or activities. Suggestions for a methodology providing a comprehensive functional analysis are offered which include descriptive analysis, hypothesis forming,…